CLM UMR-S 839 INSERM/UPMC Institut du Fer a Moulin

Transcription

CLM
Manuel Mameli, PhD
Nicolas Gervasi, PhD
Corentin Le Magueresse, PhD
UMR-S 839 INSERM/UPMC
Institut du Fer a Moulin
17 rue du Fer a Moulin
75005 Paris
UFR de biologie, UPMC
Subject: Proposal for a scientific colloquium entitled “Novel approaches to study
neuronal signal integration, computation and transduction”.
We are three young investigators supported by INSERM and working at the
Institut du Fer à Moulin (INSERM/UPMC) and the Ecole des Neurosciences de Paris.
With this letter, we are delighted to present you a proposal for a one-day scientific
colloquium that we plan to organize in Paris on October 10th 2014. This event aims to
cover the most recent advances and tool development for understanding the processes
governing synaptic integration in complex neuronal circuits and how they affect
specific behaviors.
We have assembled a line-up of internationally recognized speakers at the
forefront of their respective fields covering synaptic and dendritic integration in
neural circuits during development and adulthood, both in simple models and in the
intact brain during animal behaviors. They have all agreed to participate to the
colloquium. Given the outstanding list of speakers we wish to give to all students and
postdoctoral fellows the opportunity to attend this event. To this end, the policy of the
IFM colloquium includes free registration, which facilitates the involvement of young
scientists in their early career. We believe that this proposal has the potential to
represent a key event for the Neuroscience community in the Ile de France.
We hope that you will share our excitement and provide us with the support
necessary to make this event a scientific breakthrough.
Best regards,
Nicolas Gervasi, Corentin Le Magueresse and Manuel Mameli
5th IFM Colloquium
Novel approaches to study neuronal signal integration, computation and
transduction
– Friday October 10th 2014 –
Communication among interconnected neurons creates functional neural circuits and
underlies nearly every aspect of nervous system function. Recent advances in
molecular, electrophysiological, in vivo imaging techniques, as wells as circuit
interrogation in behaving animals have led to a rapid enhancement in our
understanding of the mechanisms that causally link structure, function and
connectivity to animal behavior. It has become increasingly clear that such
multifaceted approaches have further demonstrated the extent to which neuronal
structure and function may undergo plastic changes that contribute to development,
learning and diseases.
The 5th IFM colloquium aims to explore the integration, computational and
signal transduction properties in neural circuits, and causally linked them to animal
behavior. Two sessions will examine the recent technological advances in a wide
range of topics spanning from synaptic integration, and transduction mechanisms
implicated in the plasticity of synaptic signaling, to the probing of neural circuits
during sensory modalities, action and development. This single day event will tie
together a diversity of investigators who are at the forefront of their field making use
of multidisciplinary approach and cutting-edge techniques. In addition, two
outstanding scientists, whose work on the function of cortical activity and the role of
individual neurons in complex ensembles provide major scientific breakthroughs, will
be giving keynote lectures. An exciting aspect of this meeting is its highly
international nature bringing together European and American experts in different
areas, and fostering future developments by promoting interaction between
investigators. In the spirit of the IFM colloquium, the meeting will be highly
interactive. Concise cutting-edge presentations will be followed by intense discussion
both during the sessions and ensuing free time.
● The organizers
17 rue du Fer a Moulin – 75005 Paris –France
Email : [email protected]
Phone : +33 (0)1.45.87.61.51
N. Gervasi is a very talented INSERM researcher at the Institut du Fer a Moulin
working in the team « Neurotransmission and signalling » led by Jean-Antoine
Girault and Denis Hervé. After obtaining his PhD in the laboratory of P. Vincent
(UMR7102 UPMC) he joined the laboratory of T. Preat (ESPCI) as a postdoctoral
fellow. He is an expert in electrophysiology, intracellular signaling and cellular
imaging techniques. His main interest at the IFM is to focus on the analysis of
intracellular signaling networks and information flow from dendritic spines to
nucleus.
Phone : +33 (0)1.45.87.61.17
C. Le Magueresse is a junior INSERM investigator at the Institut du Fer à Moulin. He
completed his PhD work in the laboratories of Jean-Pierre Changeux at the Pasteur
Institute in Paris and Enrico Cherubini at the International School for Advanced
Studies in Trieste. Prior to joining IFM in 2013, he was a postdoctoral fellow in the
team led by Hannah Monyer at the German Cancer Research Center in Heidelberg.
His research focusses on cortical development and the physiology of
neurodevelopmental disorders.
Manuel Mameli, PhD
Phone : +33 (0)1.45.87.61.17
M. Mameli is a Junior Inserm PI, recipient of the 2010 ENP Chair of excellence and
ERC Starting Grant 2013 and affiliated to the Institut du Fer à Moulin since
September 2010. He was trained in the laboratories of C.F. Valenzuela (University of
New Mexico) and C. Lüscher (University of Geneva). He is an expert of
electrophysiology in vitro that he now combines with fluorescent tract-tracing,
optogenetics and behavior modeling reward and aversive encoding. His main
objective is the understanding and dissection of the synaptic circuits implicated in
saliency-related learning.
● Scientific committee
Manuel Mameli, PhD
Jean Antoine Girault, MD
Jean-Christophe Poncer, PhD
● Confirmed Speakers
The 9 following scientists at the forefront of the field of the neurobiology accepted to
be part of the symposium.
Keynote lecture (45 minutes):
Eve Marder, PhD
Volen Center for Complex Systems
Brandeis University
415 South Street
Waltham, MA 02454 - USA
Principal publications :
- SnapShot: Neuromodulation. Bucher D, Marder E. Cell. 2013 Oct 10;155(2):482-482.e1. doi:
10.1016/j.cell.2013.09.047.
- Multiple mechanisms switch an electrically coupled, synaptically inhibited neuron between
competing rhythmic oscillators. Gutierrez GJ, O'Leary T, Marder E. Neuron. 2013 Mar 6;77(5):84558
- Multiple models to capture the variability in biological neurons and networks. Marder E, Taylor AL.
Nat Neurosci. 2011 Feb;14(2):133-8
Massimo Scanziani, PhD
Center for Neural Circuits and Behavior,
La Jolla CA - USA
- Tuned thalamic excitation is amplified by visual cortical circuits. Lien AD, Scanziani M. Nat
Neurosci. 2013 Sep;16(9):1315-23
- Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct
interneurons. Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M. Nat Neurosci. 2013
Aug;16(8):1068-76
- A neural circuit for spatial summation in visual cortex. Adesnik H, Bruns W, Taniguchi H, Huang
ZJ, Scanziani M. Nature. 2012 Oct 11;490(7419):226-31.
Short lecture (30 minutes):
Nelson Spruston, PhD
Janelia Farm Research Campus
Ashburn, VA 20147
- Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by
metabotropic receptors. Graves AR, Moore SJ, Bloss EB, Mensh BD, Kath WL, Spruston N.
Neuron. 2012 Nov 21;76(4):776-89
- Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal
neurons. Katz Y, Menon V, Nicholson DA, Geinisman Y, Kath WL, Spruston N. Neuron. 2009 Jul
30;63(2):171-7.
- Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and
acetylcholine receptors. Moore SJ, Cooper DC, Spruston N. Neuron. 2009 Jan 29;61(2):287-300.
Ryohei Yasuda, PhD
Max Planck Florida Insitute for Neuroscience
Jupiter, FL 33458 – USA
- Long-distance integration of nuclear ERK signaling triggered by activation of a few
dendritic spines. Zhai S, Ark ED, Parra-Bueno P, Yasuda R. Science. 2013 Nov
29;342(6162):1107-11. doi: 10.1126/science.1245622.
- Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic
dysfunction. Szatmari EM, Oliveira AF, Sumner EJ, Yasuda R. J Neurosci. 2013 Mar
20;33(12):5367-74
Local, persistent activation of Rho GTPases during plasticity of single dendritic spines.
Murakoshi H, Wang H, Yasuda R. Nature. 2011 Apr 7;472(7341):100-4.
Graham Ellis-Davies, Professor
Mont Sinai hospital,
New York – USA
- Compartmentalization of GABAergic inhibition by dendritic spines. Chiu CQ, Lur G, Morse
TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Science. 2013 May 10;340(6133):759-62. doi:
10.1126/science.1234274.
- Two-photon uncaging of gamma-aminobutyric acid in intact brain tissue. Matsuzaki M,
Hayama T, Kasai H, Ellis-Davies GC. Nat Chem Biol. 2010 Apr;6(4):255-7. doi:
10.1038/nchembio.321. Epub 2010 Feb 21.
- Two-color, two-photon uncaging of glutamate and GABA. Kantevari S, Matsuzaki M,
Kanemoto Y, Kasai H, Ellis-Davies GC. Nat Methods. 2010 Feb;7(2):123-5. doi:
10.1038/nmeth.1413. Epub 2009 Dec 27
Thomas Mrsic-Flogel, PhD
University College of London
21 University Street, London.
- Cortical connectivity and sensory coding. Harris KD, Mrsic-Flogel TD. Nature. 2013 Nov
7;503(7474):51-8.
- The emergence of functional microcircuits in visual cortex. Ko H, Cossell L, Baragli C, Antolik J,
Clopath C, Hofer SB, Mrsic-Flogel TD. Nature. 2013 Apr 4;496(7443):96-100.
- Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual
cortex. Hofer SB, Ko H, Pichler B, Vogelstein J, Ros H, Zeng H, Lein E, Lesica NA, Mrsic-Flogel TD.
Nat Neurosci. 2011 Jul 17;14(8):1045-52
SongHai Shi, PhD
Sloan Kettering Institute
1275 York Ave
New York – USA
- Lineage-dependent circuit assembly in the neocortex. Gao P, Sultan KT, Zhang XJ, Shi SH.
Development. 2013 Jul;140(13):2645-55.
- Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly.
Yu YC, He S, Chen S, Fu Y, Brown KN, Yao XH, Ma J, Gao KP, Sosinsky GE, Huang K, Shi SH.
Nature. 2012 May 2;486(7401):113-7.
- Clonal production and organization of inhibitory interneurons in the neocortex. Brown KN,
Chen S, Han Z, Lu CH, Tan X, Zhang XJ, Ding L, Lopez-Cruz A, Saur D, Anderson SA, Huang K, Shi
SH. Science. 2011 Oct 28;334(6055):480-6.
Rui Costa, PhD
Champalimaud Neuroscience Institute
Lisbon – Portugal.
- Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and
habitual actions. Gremel CM, Costa RM. Nat Commun. 2013;4:2264.
- Concurrent activation of striatal direct and indirect pathways during action initiation. Cui G,
Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM, Costa RM. Nature. 2013 Feb 14;494(7436):23842.
- Start/stop signals emerge in nigrostriatal circuits during sequence learning. Jin X, Costa RM.
Nature. 2010 Jul 22;466(7305):457-62.
Sidney Wiener, PhD
- Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats.
Arleo A, Déjean C, Allegraud P, Khamassi M, Zugaro MB, Wiener SI. J Neurosci.;33(42):16790-5.
-Dynamics of decision-related activity in hippocampus. Catanese J, Cerasti E, Zugaro M, Viggiano
A, Wiener SI. Hippocampus. 2012;22(9):1901-11.
-Coherent theta oscillations and reorganization of spike timing in the hippocampal- prefrontal
network upon learning. Benchenane K, Peyrache A, Khamassi M, Tierney PL, Gioanni Y, Battaglia
FP, Wiener SI. Neuron. 2010; 66(6):921-36.
- Type 4 phosphodiesterase plays different integrating roles in different cellular domains
in pyramidal cortical neurons. Castro LR, Gervasi N, Guiot E, Cavellini L, Nikolaev VO,
Paupardin-Tritsch D, Vincent P. J Neurosci. 2010 Apr 28;30(17):6143-51. doi:
10.1523/JNEUROSCI.5851-09.2010.
- PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga
adenylyl cyclase and spatial regulation by dunce phosphodiesterase. Gervasi N, Tchénio P,
Preat T. Neuron. 2010 Feb 25;65(4):516-29. doi: 10.1016/j.neuron.2010.01.014.
● Institutional support and potential audience
The 2014 Institut du Fer a Moulin (IFM) colloquium follows a successful yearly
series started in 2010. Past editions covered topics spanning from cortical
development, synaptic circuits on health and disease, neuropsychiatric disorders, and
connectomics. All editions resulted in a large attendance making this an attractive
scientific event in the Paris area for french and foreign scientists. The IFM directed by
Jean-Antoine Girault is a research center affiliated to INSERM and University Pierre
and Marie Curie (UPMC) devoted to the study of the development and plasticity of
the nervous system. The IFM is constituted by 10 research group representing around
100 scientists. It gives an opportunity to young investigators to organize scientific
events of a great scientific impact in the “Ile de France” region providing dynamism,
support and experience necessary to realize such events.
Research in basic neuroscience in “Ile de France” spans from channel function, to
pathophysiology of neural networks and cellular basis of behavior, in more than a
hundred laboratories. In addition many clinical neuroscience groups have
complementary interests. Considering that synaptic basis of disease and dissecting
neural circuits are two hot-topics in the neuroscience field, our symposium sounds
very attractive for basic and clinical neuroscientists coming from Paris regions and
other areas. Free open access to the event will be facilitating the participation of
students and scientists of all levels. Based on the past events we expect about 150-200
participants.
● A program outline.
8.45 – Introductory remarks – Jean Antoine Girault, Director IFM
9.00 – Keynote Lecture:
E Marder: Variability, robustness and modulation of neurons and circuits
10.00 – 10.15 Coffee break
10.15 – Session 1: Integration of transduction of neuronal singals
N Spruston: Dendritic Integration, Plasticity, and Diversity in Hippocampal
Pyramidal Neurons
R Yasuda: To be announced
G. Ellis-Davis: Two color uncaging
N Gervasi: Imaging and modeling signaling pathway integration in neurons
12.00 – 14.00 Lunch
14.15 – Session 2: From Neural circuits dynamics to behavior
S Shi To be announced
T Mrsic-Flogel: To be announced
R Costa: Generating and shaping novel action repertoires
S Wiener: Set-shifting behaviors and hippocampal-prefrontal striatal pathway
activity
16.15 – 16.30 – Coffee break
16.30 – Keynote Lecture
M Scanziani : Cortical Circuits of Vision
17.30 – 19.00 Session 3: Cocktail
● Tentative budget
Expenses
Requested
Support (Euros)
Sponsor
DIM Cerveau Pensée (to request)
Sub-total
-
10,000.00
Ecole de Neuroscience de Paris (To request)
5,000.00
Institut du Fer a Moulin (Confirmed)
3,000.00
Nature Methods
2000
Leica Microsystems
4000
Coherent
1000
Coffee Breaks and Catering
Café
2,500.00
2500.00
Auditorium renting
Institut du Globe Amphiteater
5,000.00
5,000.00
Accomodation
XXXXXX
3,500.00
3,500.00
Speakers Travel Expenses
1 X Train ticket London-Paris-London
1 X Airfare ticket Waltham-Paris-Waltham
1 X Airfare ticket Lisbon-Paris-Lisbon
9,400.00
600.00
1,700.00
600.00
1 X Airfare ticket San Diego-Paris-San Diego
1,400.00
1 X Airfare ticket New York-Paris-New York
1,400.00
1 X Airfare tickets Miami - Paris- Miami
1,700.00
Food
6,800.00
Final banquet
2,000.00
Lunch Friday
2,800.00
Dinner Friday
2,000.00
Total (HT)
27,200.00
-
Curriculum Vitae
Manuel Mameli
Date and place of birth:
Citizenship:
Marital status:
Children:
Personal address:
Work address:
Phone:
E-mail address:
Languages :
French: oral
August 3rd, 1978; Cagliari, Italy
Italian
Married
2
7 rue Parmentier 92130 Issy les Moulineaux (FRA).
Institut du Fer à Moulin (INSERM/UPMC)
17 Rue du Fer à Moulin, 75005 Paris (FRA)
+33 (0)1.45.87.61.17
[email protected]
Italian: mother tongue; English: oral and written;
I - Current position:
September 2010 - present
CR1 Inserm
ENP “Chair of Excellence 2010” Junior Group Leader
Institution: Institut du Fer a Moulin (INSERM/UPMC),
Director: Dr. Jean-Antoine Girault, MD, PhD.
II - Education:
September 1992 – July 1997
Bachelor training
Maturita’ Scientifica (High School, Scientific Area), Liceo Scientifico “Alberti LB”
Cagliari, Italy
Final Grade: 50/60
October 1997 - July 2002
Undergraduate training
Laurea in Biological Sciences (Doctor in Biology), University of Cagliari, Italy
Thesis title:“Gamma-Hydroxybutirate (GHB) action on the spontaneous activity of rat
hippocampal pyramidal neurons in primary culture”.
Advisor: Enrico Sanna, Ph.D. University of Cagliari, Italy.
Final Grade: 110/110 summa cum laude
January 2006 – February 2009
Graduate training
Ph.D. student of the International Lemanic Doctoral School
Thesis entitled: Controlling the persistence of cocaine-evoked plasticity in the
mesolimbic dopamine system
Institution: University of Geneva, Department of Basic Neuroscience,
Advisor: Prof. C. Lüscher MD, PhD..
III - Working experience
July 2002 – September 2002:
Research Fellow,
Dept. of Experimental Biology,
Division of Neuroscience, Laboratory of Electrophysiology,
University of Cagliari, Italy.
Advisor: Enrico Sanna, Ph.D..
October 2002 – December 2005:
Research Fellow,
Dept. of Neurosciences,
University of New Mexico, Albuquerque, NM (USA).
Advisor: C. Fernando Valenzuela, M.D., Ph.D..
January 2006 – August 2010
Research Fellow
University of Geneva, Department of Basic Neuroscience,
Advisor: Prof. C. Lüscher MD, PhD..
IV – Selected Publications
Maroteaux M., Mameli M.. Cocaine-evokes projection-specific synaptic plasticity in
the lateral habenula. JNeurosci. 2012 5;32(36):12641-6.
Mameli M., Bellone C., Brown T.C., Lüscher C. Cocaine inverts rules for synaptic
plasticity of glutamate transmission in the VTA. Accepted. Nature Neuroscience.
Brown T.C., Mameli M., Bellone C., Balland B., Dahan L., Lujan R., Deisseroth K.,
Lüscher C. Drug-driven AMPA receptor redistribution mimicked by selective
dopamine neuron stimulation. PLoSOne 2011. In press.
Mameli M., Halbout B., Creton C., Engblom D., Parkitna J. R., Spanagel R., Lüscher
C.. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in
the NAc. Nat Neurosci. 2009 Aug;12(8):1036-41. Epub 2009 Jul 13.
Engblom D., Bilbao A., Sanchis-Segura C., Dahan L., Pereau-lenz S., Balland B.,
Parkitna J.R., Lujan R., Halbout B., Mameli M., Parlato R., Sprengel R., Lüscher C.,
Schütz G., Spanagel R.. Glutamate receptors on dopamine neurons control the
persistence of cocaine-seeking. Neuron 2008 Aug 14; 59(3):497-508.
Mameli M., Balland B., Lujan R., Lüscher C.. Rapid synthesis and synaptic insertion
of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 July;
317(5837):530-3.
Mameli M. and Valenzuela C.F.. Alcohol increases efficacy of immature synapses in
a neurosteroid- dependent manner. Eur. J. Neurosci. 2006 Feb; 23(3):835-9.
Carta M., Mameli M.* and Valenzuela C.F.. Alcohol potently modulates climbing
fibers-to-purkinje neuron synapses: role of metabotropic glutamate receptors. J.
Neurosci. 2006 Feb 15; 26(7):1906-12.
Mameli M., Zamudio P.A., Carta M., Valenzuela C.F.. Developmentally regulated
actions of alcohol on hippocampal glutamatergic transmission. J. Neurosci. 2005 Aug
31; 25(35):8027-36.
Mameli M., Carta M., Partridge L.D., Valenzuela C.F.. Neurosteroid-induced
plasticity of immature synapses via retrograde modulation of presynaptic NMDA
receptors. J. Neurosci. 2005, 25 (9), 2285-94.
Carta M., Mameli M., Valenzuela C.F.. Alcohol enhances GABAergic transmission to
cerebellar granule cells via an increase in golgi cell excitability. J. Neurosci. 2004, 24
(15), 3746-51.
*Equally contributed
Curriculum Vitae
Nicolas Gervasi
Citizenship:
Marital status:
Children:
Personal address:
Work address:
Phone:
E-mail address:
Languages :
July 5st, 1979; Maison-Alfort, France
French
Married
2
120 Avenue Daumesnil 75012 Paris (FRA).
+33 (0)1.45.87.61.53
[email protected]
French: mother tongue; English: oral and written
September 2010 - present
Post-doctorant Team Neurotransmission and signaling
II - Education:
September 1994 – July 1997
Bachelor training
Baccalauréat Scientifique spécialité Mathématiques. Lycée Edouard Branly, Nogentsur-marne, France.
September 2002
D.E.A. de Neurosciences, Université Pierre et Marie Curie (UMPC), Paris, France.
Advisor: Nathalie Leresche, Ph.D. UPMC, Paris, France.
Mention : Très Bien.
Octobre 2002 – February 2006
Graduate training
Ph.D. student of the Cerveau, cognition, comportement doctoral school (ED3C).
Thesis entitled: Dynamique spatio-temporelle et régulation de l’activité de la PKA
dans des préparations de neurones de souris en tranche et mécanisme cellulaire
d’action du GHB dans le thalamus ventrobasal.
Institution: UMPC, UMR7102 Neurobiologie des Processus Adaptatifs,
Advisor: Dr. P. Vincent PhD..
February 2001 – June 2001:
Research Fellow,
UMR7102 Neurobiologie des Processus Adaptatifs,
Team of Cellular Neurobiology Cellulaire,
UPMC, France.
Advisor: Nathalie Leresche, Ph.D..
September 2001 – February 2006:
Research Fellow,
UMR7102 Neurobiologie des Processus Adaptatifs,
Team of Neuromodulator and second messengers dynamics,
UPMC, France.
Advisor: P. Vincent Ph.D..
February 2006 – April 2010
Research Fellow
UMR 7637 Neurobiologie
Team Genes and dynamics of memory systems.
Ecole Supérieure de Physique et Chimie Industrielle (ESPCI), Paris, France.
Advisor: T. Préat PhD..
IV - Publications
Castro, L.R.V., Gervasi, N. et al. Type 4 phosphodiesterase plays different integrating
roles in different cellular domains in pyramidal cortical neurons. J. Neurosci. 30,
6143-6151 (2010).
Gervasi, N., Tchénio, P. & Preat, T. PKA dynamics in a Drosophila learning center:
coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce
phosphodiesterase. Neuron. 65, 516-529 (2010).
Vincent, P., Gervasi, N. & Zhang, J. Real-time monitoring of cyclic nucleotide
signaling in neurons using genetically encoded FRET probes. Brain Cell Biol. 36, 317 (2008).
Hepp, R. Tricoire, L., Hu, E., Gervasi, N., Paupardin-Tritsch, D., Lambolez, B.,
Vincent P. Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living
thalamic neurons. J. Neurochem. 102, 1875-1886 (2007).
Gervasi, N. et al. Dynamics of protein kinase A signaling at the membrane, in the
cytosol, and in the nucleus of neurons in mouse brain slices. J. Neurosci. 27, 27442750 (2007).
Gervasi, N. et al. Pathway-specific action of gamma-hydroxybutyric acid in sensory
thalamus and its relevance to absence seizures. J. Neurosci. 23, 11469-11478 (2003).
Curriculum Vitae
Corentin Le Magueresse
Citizenship:
Personal address:
Work address:
Phone:
E-mail address:
Languages :
September 27th, 1977; Machecoul, France
French
3 rue de Sévigné 75004 Paris (FRA).
+33 (0)1.45.87.61.49
[email protected]
French: mother tongue; English: oral and written
February 2013 - present
INSERM Investigator (“chargé de recherche”), Team
II - Education:
October 1995 – September 2001:
Diplôme d’ingénieur (MSc) in Chemical Engineering, Ecole Nationale Supérieure de
Chimie, Montpellier, France
D.E.A. (MPhil) in Neuropharmacology, Université Paris 7 - Diderot, Paris, France.
Advisor: Jean-Pierre Changeux, Ph.D. Institut Pasteur, Paris, France.
October 2001 – September 2006
Graduate training
Ph.D. student of the Cerveau, cognition, comportement doctoral school (ED3C).
Thesis entitled: contribution des récepteurs nicotiniques de l'acétylcholine à la
modulation de l'activité synaptique et des synchronisations de neurones dans le cortex
hippocampique immature
Advisors : Jean-Pierre Changeux, Ph.D (Paris). and Enrico Cherubini, Ph.D (Trieste).
October 2001 – September 2006:
Research Fellow,
Récepteurs et Cognition team, Institut Pasteur, France
and Department of Neurobiology, International School for Advanced Studies, Italy
Advisors : Jean-Pierre Changeux, Ph.D. and Enrico Cherubini, Ph.D.
November 2006 – January 2013:
Research Fellow,
Department of Clinical Neurobiology, German Cancer Research Center, Germany
Advisor: H. Monyer, M.D.
IV - Publications
Le Magueresse C, Monyer H. GABAergic interneurons shape the functional
maturation of the cortex. Neuron 77(3):388-405 (2013). Review article.
Khodosevich K, Zuccotti A, Kreuzberg MM, Le Magueresse C, Frank M, Willecke
K, Monyer H. Connexin45 modulates the proliferation of transit-amplifying precursor
cells in the mouse subventricular zone. PNAS 109(49):20107-12 (2012).
Caputi A, Fuchs EC, Allen K, Le Magueresse C, Monyer H.Selective reduction of
AMPA currents onto hippocampal interneurons impairs network oscillatory activity.
PLoS One. 7(6):e37318 (2012)
Alfonso J#, Le Magueresse C#, Khodosevich K, Monyer H. Diazepam Binding
Inhibitor promotes proliferation of neural progenitors in the SVZ by reducing GABA
signaling. Cell Stem Cell, 10(1):76-87 (2012) # equal contribution
Le Magueresse C#, Alfonso J#, Bark C, Eliava M, Khrulev S, Monyer H.
Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate
radially to the cortex. Cerebral Cortex. 22(10):2285-96 (2012) # equal contribution
Le Magueresse C#, Alfonso J#, Khodosevich K, Bark C, Monyer H. “Small axonless
neurons”: postnatally generated neocortical interneurons with delayed functional
maturation. Journal of Neuroscience. 31(46):16731-47 (2011). # equal contribution
Le Magueresse C, Cherubini E. Presynaptic calcium stores contribute to nicotineelicited potentiation of evoked synaptic transmission at CA3-CA1 connections in the
neonatal rat hippocampus. Hippocampus 17(4):316-25 (2007)
Le Magueresse C, Safiulina V, Changeux JP, Cherubini E. Nicotinic modulation of
network and synaptic transmission in the immature hippocampus investigated with
genetically modified mice. Journal of Physiology 576(2):533-46 (2006)
Maggi L, Sola E, Minneci F, Le Magueresse C, Changeux JP, Cherubini E. Persistent
decrease in synaptic efficacy induced by nicotine at Schaffer collateral-CA1 synapses
in the immature rat hippocampus. Journal of Physiology 559(3):863-74 (2004)
Maggi L, Le Magueresse C, Changeux JP, Cherubini E. Nicotine activates immature
"silent" connections in the developing hippocampus. PNAS 100(4):2059-64 (2003)

CLM UMR-S 839 INSERM/UPMC Institut du Fer a Moulin

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Overcoming Implementing Increasing Cooperating

Hospital-Wide Awards $2,500 Team Awards (2) Poster #

Change in Program Plan – Graduate Studies

The Relational Pulse: Controversies, Caricatures and Clinical Wisdom

4 COMPLEMENTARY ACTIVITY SECTORS