124 (19)

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2014 124: 2895-3034
124 (19)
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6 NOVEMBER 2014 x VOLUME 124, NUMBER 19
CONTENTS
COVER FIGURE
Hyaluronan is detected on the endothelial surface, in subendothelial tissues, and in
germinal centers of B-cell follicles of a reactive lymph node. For comparison with
Hodgkin lymphoma, see the article by Fhu et al on page 2973.
INSIDE BLOOD COMMENTARIES
2895
Heparan sulfate: a stem cell therapy target?
Timothy S. Olson
Comment on Saez et al, page 2937
2897
Lymphotoxin-a keeps the gate open for T-cell infiltration in cHL
Uta E. H¨opken
Comment on Fhu et al, page 2973
2898
Hit the spleen, JAK!
Steven W. Lane and Ann Mullally
Comment on Wang et al, page 2987
2900
Leukemia cells make ruthless competitors
Ravi Bhatia
Comment on Kagoya et al, page 2996
2901
Identifying mutant pathways in the histiocytoses
H. Miles Prince
Comment on Chakraborty et al, page 3007, and on Emile et al, page 3016
PLENARY PAPER
2905
Dominant unit CD341 cell dose predicts engraftment after double-unit cord blood
transplantation and is influenced by bank practice
Duncan Purtill, Katherine Smith, Sean Devlin, Richard Meagher, Joann Tonon, Marissa Lubin,
Doris M. Ponce, Sergio Giralt, Nancy A. Kernan, Andromachi Scaradavou, Cladd E. Stevens,
and Juliet N. Barker
HOW I TREAT
2913
How I treat Burkitt lymphoma in adults
Caron Jacobson and Ann LaCasce
CLINICAL TRIALS AND
OBSERVATIONS
2921
A phase 1/2 study of an adjuvanted varicella-zoster virus subunit vaccine in
autologous hematopoietic cell transplant recipients
Edward A. Stadtmauer, Keith M. Sullivan, Francisco M. Marty, Sanjeet S. Dadwal,
Genovefa A. Papanicolaou, Thomas C. Shea, Sherif B. Mossad, Charalambos Andreadis,
Jo-Anne H. Young, Francis K. Buadi, Mohamed El Idrissi, Thomas C. Heineman,
and Elchonon M. Berkowitz
2930
Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic
anemia: a GIMEMA study of 308 patients
Wilma Barcellini, Bruno Fattizzo, Anna Zaninoni, Tommaso Radice, Ilaria Nichele, Eros Di Bona,
Monia Lunghi, Cristina Tassinari, Fiorella Alfinito, Antonella Ferrari, Anna Paola Leporace,
Pasquale Niscola, Monica Carpenedo, Carla Boschetti, Nicoletta Revelli, Maria Antonietta Villa,
Dario Consonni, Laura Scaramucci, Paolo De Fabritiis, Giuseppe Tagariello, Gianluca Gaidano,
Francesco Rodeghiero, Agostino Cortelezzi, and Alberto Zanella
v
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CONTINUED ON vi
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HEMATOPOIESIS AND
STEM CELLS
2937
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and
enables engraftment without cytotoxic conditioning
Borja Saez, Francesca Ferraro, Rushdia Z. Yusuf, Colleen M. Cook, Vionnie W. C. Yu,
Ana Pardo-Saganta, Stephen M. Sykes, Rahul Palchaudhuri, Amir Schajnovitz, Sutada Lotinun,
Stefania Lymperi, Simon Mendez-Ferrer, Raquel del Toro, Robyn Day, Radovan Vasic,
Sanket S. Acharya, Roland Baron, Charles P. Lin, Yu Yamaguchi, Amy J. Wagers,
and David T. Scadden
2948
Brief Report
OVOL2 is a critical regulator of ER71/ETV2 in generating FLK11, hematopoietic,
and endothelial cells from embryonic stem cells
Ju Young Kim, Ra Ham Lee, Tae Min Kim, Dong-Wook Kim, Young-Joo Jeon, Sung-Ho Huh,
Se-Yeong Oh, Michael Kyba, Hiroshi Kataoka, Kyunghee Choi, David M. Ornitz, Jung-Il Chae,
and Changwon Park
IMMUNOBIOLOGY
2953
An autologous leukemia cell vaccine prevents murine acute leukemia relapse after
cytarabine treatment
John D. Gibbins, Lindsay R. Ancelet, Robert Weinkove, Benjamin J. Compton, Gavin F. Painter,
Troels R. Petersen, and Ian F. Hermans
2964
Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that
results in nonprocessable p100
Cindy Eunhee Lee, David A. Fulcher, Belinda Whittle, Rochna Chand, Nicole Fewings,
Matthew Field, Daniel Andrews, Christopher C. Goodnow, and Matthew C. Cook
LYMPHOID NEOPLASIA
2973
Reed-Sternberg cell–derived lymphotoxin-a activates endothelial cells to enhance
T-cell recruitment in classical Hodgkin lymphoma
Chee Wai Fhu, Anne M. Graham, Celestial T. Yap, Suhail Al-Salam, Antonio Castella,
Siew Meng Chong, and Yaw-Chyn Lim
2983
Brief Report
Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral
T-cell lymphomas: high correlation with mRNA levels
C´eline Bossard, Maria Pamela Dobay, Marie Parrens, Laurence Lamant, Edoardo Missiaglia,
Corinne Haioun, Antoine Martin, Bettina Fabiani, Richard Delarue, Olivier Tournilhac,
Mauro Delorenzi, Philippe Gaulard, and Laurence de Leval
MYELOID NEOPLASIA
2987
JAK2 inhibitors do not affect stem cells present in the spleens of patients with
myelofibrosis
Xiaoli Wang, Fei Ye, Joseph Tripodi, Cing Siang Hu, Jiajing Qiu, Vesna Najfeld, Jesse Novak,
Yan Li, Raajit Rampal, and Ronald Hoffman
2996
JAK2V617F1 myeloproliferative neoplasm clones evoke paracrine DNA damage to
adjacent normal cells through secretion of lipocalin-2
Yuki Kagoya, Akihide Yoshimi, Takako Tsuruta-Kishino, Shunya Arai, Takashi Satoh,
Shizuo Akira, and Mineo Kurokawa
3007
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support
a central role for ERK activation in LCH pathogenesis
Rikhia Chakraborty, Oliver A. Hampton, Xiaoyun Shen, Stephen J. Simko, Albert Shih,
Harshal Abhyankar, Karen Phaik Har Lim, Kyle R. Covington, Lisa Trevino, Ninad Dewal,
Donna M. Muzny, Harshavardhan Doddapaneni, Jianhong Hu, Linghua Wang, Philip J. Lupo,
M. John Hicks, Diana L. Bonilla, Karen C. Dwyer, Marie-Luise Berres, Poulikos I. Poulikakos,
Miriam Merad, Kenneth L. McClain, David A. Wheeler, Carl E. Allen, and D. Williams Parsons
vi
BLOOD, 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19
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3016
Brief Report
Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease
Jean-François Emile, Eli L. Diamond, Zofia H´elias-Rodzewicz, Fleur Cohen-Aubart,
Fr´ed´eric Charlotte, David M. Hyman, Eunhee Kim, Raajit Rampal, Minal Patel, Chezi Ganzel,
Shlomzion Aumann, Gladwys Faucher, Catherine Le Gall, Karen Leroy, Magali Colombat,
Jean-Emmanuel Kahn, Salim Trad, Philippe Nizard, Jean Donadieu, Val´erie Taly, Zahir Amoura,
Omar Abdel-Wahab, and Julien Haroche
BLOOD WORK
3020
Histiocytic clearance of neoplastic cells in acute promyelocytic leukemia
Kristian T. Schafernak and Seth J. Corey
CORRESPONDENCE
3021
In contemporary patients with polycythemia vera, rates of thrombosis and risk
factors delineate a new clinical epidemiology
Tiziano Barbui, Alessandra Carobbio, Elisa Rumi, Guido Finazzi, Heinz Gisslinger,
Francesco Rodeghiero, Maria Luigia Randi, Alessandro Rambaldi, Bettina Gisslinger,
Lisa Pieri, Irene Bertozzi, Ilaria Casetti, Animesh Pardanani, Francesco Passamonti,
Alessandro M. Vannucchi, and Ayalew Tefferi
3023
Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in
T-ALL
Jonathan Bond, Aur´elie Bergon, Amandine Durand, Isabelle Tigaud, Xavier Thomas,
Vahid Asnafi, Salvatore Spicuglia, and Elizabeth Macintyre
3025
Two types of amyloid in a single heart
Shameem Mahmood, Janet A. Gilbertson, Nigel Rendell, Carol J. Whelan, Helen J. Lachmann,
Ashutosh D. Wechalekar, Philip N. Hawkins, and Julian D. Gillmore
3027
A germ line mutation in cathepsin B points toward a role in asparaginase
pharmacokinetics
Laurens T. van der Meer, Esm´e Waanders, Marloes Levers, Hanka Venselaar, Debbie Roeleveld,
Joachim Boos, Claudia Lanvers, Roger J. Br¨uggemann, Roland P. Kuiper, Peter M. Hoogerbrugge,
Frank N. van Leeuwen, and D. Maroeska te Loo
3029
Bendamustine, etoposide, cytarabine, melphalan, and autologous stem cell rescue
produce a 72% 3-year PFS in resistant lymphoma
Giuseppe Visani, Pietro Maria Stefani, Saveria Capria, Lara Malerba, Piero Galieni,
Francesco Gaudio, Giorgina Specchia, Giovanna Meloni, Filippo Gherlinzoni, Roberta Gonella,
Marco Gobbi, Armando Santoro, Felicetto Ferrara, Marco Rocchi, Enrique M. Ocio,
Maria Dolores Caballero, Federica Loscocco, and Alessandro Isidori
3031
Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic
effect in hemophilia treatment
Jagan Sundaram, Usha R. Pendurthi, Charles T. Esmon, and L. Vijaya Mohan Rao
ERRATA
3034
viii
Young JA, Ting KK, Li J, et al. Regulation of vascular leak and recovery from
ischemic injury by general and VE-cadherin–restricted miRNA antagonists of
miR-27. Blood. 2012; 122(16):2911-2919.
BLOOD, 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19
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OTHER DEPARTMENTS
xx
Author Guide
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BLOOD, 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19