Local MedTech industry in excellent shape

G r e n o b l e - I s è r e - F r a n c e
AEPI 2014
Local MedTech industry
in excellent shape
• Technological breakthroughs in:
medical and surgical robotics,
bioinformatics, healthcare information systems,
imaging, diagnostics,
drug delivery systems.
• Global medtech leaders and innovative start-ups.
• An innovation ecosystem unparalleled in Europe.
• A testing ground for new developments in
« e-healthcare » and the « silver economy »
Introduction
T
he number of new drugs released on the market each
year has been on the decline for the past decade. The
€200-billion medical technology market, on the
other hand, has been growing steadily for fifty
years and is now bustling along at a growth rate
of 10% per year. Industry heavyweights such as
GE Healthcare, Becton Dickinson, Roche Diagnostics, and
Covidien—four of the global medtech industry
“big ten”—have set up operations in Grenoble-Isère.
The local area is also home to many smaller, yet no less
innovative, companies including Tornier, the number-one in
shoulder and hip prostheses; global X-ray imaging leader
Trixell; and bioMérieux, which develops groundbreaking
solutions for in vitro diagnostics.
M
edical technology is today a major driver of
medical advances. However, this highly-fragmented
industry is characterized by seemingly-disparate
products and services covering fields such as
imaging, diagnostics, biochips, surgical robotics and
software, sensors, instrumentation, prosthetics, implants,
e-healthcare, and assisted living.
C
ompanies that design and manufacture products
for preventive, diagnostic, and therapeutic medicine
and patient monitoring—along with their suppliers and
the developers of the technologies that go into their
products—are all part of the medtech ecosystem. This
multidisciplinary industry, at the crossroads of
healthcare and technology, leverages a broad array
of expertise to develop applications for some of the latest
advances in fields like physics chemistry, materials, IT,
biotech, and micro- and nanotechnology.
D
igital technologies are offering deeper insights into
living organisms, opening up a world of new possibilities
in diagnostics, treatments, and patient outcomes. These
technologies also underpin personalized healthcare,
which aims to better-target preventive and therapeutic
medicine to individual patient needs. Digital technologies
also enable developments such as communicating medical
systems, which will see rising demand as the population
ages.
G
renoble-Isère, an international hub for micro- and nanotechnology and software, is the ideal location for companies
seeking to carve out a position in the rapidly-growing medtech industry.
T
he area is home to some of the world’s best research centers. The local innovation ecosystem has attracted
leading multinationals and has spurred the creation of a growing cohort of start-ups. Local organizations, including
Medic@lps, Tasda, and the Minalogic and Lyonbiopôle clusters are also active participants in the medtech industry,
providing a range of services to support innovation, from training through R&D project engineering and help securing
financing.
2
AEPI - MedTech 2014
Contents
From biotech to e-healthcare ........................................................................................................................ 4
Grenoble University Hospital Center — Leading the way in innovation
and clinical trials ....................................................................................................................................................... 6
Computer-assisted medicine and surgery — Grenoble-Isère,
where pioneering innovations are born ................................................................................................ 8
Drug delivery systems — Getting treatments to their target ..............................................10
Bioinformatics and healthcare information systems — Software to power
medtech solutions .....................................................................................................................................................12
Medical imaging — Fuelling the expansion of personalized medicine ......................... 14
Medical diagnostics — Home to global leaders and innovative start-ups .................16
The silver economy — Local stakeholders leading the way ..................................................18
Medical research and innovation — A unique ecosystem ..................................................... 20
Higher education — Multidisciplinary programs designed to meet
medtech needs .......................................................................................................................................................... 25
Development opportunities for all medtech stakeholders ................................................... 27
Grenoble-Isère medtech industrial actors ......................................................................................... 28
AEPI - MedTech 2014
3
From biotech
Biotechnology & pharmaceuticals
Biotherapies (recombinant-protein, stem-cell, and neural and functional cell-culture therapies) and
personalized medicine.
Drug development, FDA-approved manufacturers, vaccines, and aromatic molecules.
Implants, microsystems & prostheses
Miniaturized implantable and non-implantable medical systems (implantable cardiac defibrillators
and pacemakers).
Biocompatible materials and prostheses.
MEMS and nanomaterials.
Drug-delivery systems (DDS)
Injection and IV, anesthesia, and micro-injection systems.
Packaging.
Nanoparticles and targeted drug delivery.
Medical equipment & instrumentation
Surgical robotics and augmented medicine and surgery.
Medical imaging (radiological detectors, X-ray, gamma-ray, synchrotron radiation, tomography,
and fluorescence imaging).
Medical equipment for assisted living (modelling of physical space and movement, embedded and
non-embedded sensors).
Laboratory and research instrumentation, cell culture materials, crystallography.
Diagnostics
In vivo (molecular imaging, preclinical imaging, reagents, radioactive tracers, fluorescent markers,
biopsy systems).
In vitro (nanomaterials, nanostructures, biomarkers, microfluidics, and biochips such as DNA chips
and labs-on-chip).
Engineering & services
IT (medical and healthcare management software, patient data management software, databases,
bioinformatics, modelling).
Contract Research Organizations (clinical trials, regulatory consulting).
Consumables.
Assisted living services.
4
AEPI - MedTech 2014
to e-healthcare
s, microsyste
t
n
m
pla
s
&
Im
c e u ti c a l s
Dru g
-de
li
y
ver
ec hn ol o g
ses
y&
e
sth
o
pr
rm a
a
h
p
Bi ot
s ys t e m s
...
(
...
DD
S)
En
g
in s
...
...
en
t&
r vi
n g & se
tr u m e n t a ti o n
i
n
e
e ri
ces
Innovative Pharmaceutical Packaging
...
Dia
Me
di c a l e q ui p m
g n o s ti c s
AEPI - MedTech 2014
5
Grenoble University
Hospital Center
France’s 3rd leading center for
neurosurgery & trauma center
Ranked 13th in France by budget and
range of care offered
1,045 clinical trials in progress led by:
35% Medical/pharmaceutical
companies
26% Academic research labs
24% Grenoble University Hospital
Center
17% Other teaching hospitals
130,000 inpatient stays/year
650,000 outpatient consultations per
year
91,000 ER admissions/year
€620 million annual operating budget
8,000 employees (including 1,800
healthcare professionals)
T
he Grenoble University Hospital Center (CHUG) is one of the region’s leading
healthcare facilities. It is also one of Grenoble-Isère’s largest employers, with an
8,000-strong staff from more than 100 professions, each of which contributes to
the center’s missions of teaching, research, and patient care. The center is divided
into six specialized units (imaging, biology, pharmacy, research, public health,
and OR) and conducts world-caliber biomedical research in robotics for neurology
and minimally-invasive surgery. It also boasts recognized expertise in research,
and clinical, biological, and—above all—technological development.
The center’s well-structured research programs are built on a large number of
partnerships and address clearly-defined, high-potential research areas which
include neuroscience, chronic disease, life sciences engineering, cancer,
ontogenesis, infectious agents, and procreation.
Targeted organizations to support research within CHUG
Clinical trials are crucial to getting new drugs and other treatments to patients.
They are also a necessary step in the process of developing new medical
technologies. And to make the process smother, more effective, and faster, the
center’s research unit works closely with partners such as Grenoble University,
the French National Center for Scientific Research (CNRS), the French Institute
of Health and Medical Research (Inserm), the French Alternative Energies and
Atomic Energy Commission (CEA), the French Blood Bank (EFS), the European
Synchrotron Radiation Facility (ESRF), and the Institute for Structural Biology (IBS),
among others, via several organizations:
• A Center for Clinical Investigation to support biologists, clinicians, and
researchers; which features a unit especially dedicated to technological
innovation (CIC-IT),
• A Biology Resource Center (CRB) for cancer research.
• The Clinatec research center, which develops and tests innovative
approaches leveraging micro- and nanotechnology and electronics,
primarily in the field of neurostimulation.
6
AEPI - MedTech 2014
Leading the way in innovation
and clinical trials
Speeding the innovation process
The Center for Clinical Investigation-Technological Innovation (CIC-IT), located
on the Grenoble University Hospital Center campus, is one of the eight
technological innovation facilities in France to have earned certification from
Inserm, the French National Institute for Healthcare and Medical Research. The
lab’s aim is to help bring innovations to maturity as quickly as possible, with
research activities ranging from clinical proof-of-concept studies to therapeutic
value assessments.
CIC-IT’s Maxithec, a lab that aims to boost the effects of expert targeted
therapies, is France’s only research organization to focus on medical systems
for augmented surgery. The lab also develops new tools and methods to assess
the therapeutic value of innovative medical systems—a significant competitive
advantage for the manufacturers of those systems.
Grenoble University Hospital Center’s CIC-IT boasts more than two decades of
experience in healthcare information systems engineering. It is a place where
clinicians, researchers, and manufacturers can work together at every step of
the way (design, prototyping, pre-series manufacturing, and therapeutic value
assessment) to get medtech innovations to patients faster.
A major provider of clinical research services
The CRO (contract research organization) Biomatech is Europe’s leading provider
of consulting and preclinical and clinical trials for medical systems and the
associated biotechnologies. Biomatech holds all of the necessary accreditations
and has pharmaceutical-company status under French law.
With more than 100 employees (including 30 research scientists) and 25 years
of experience, the company, a subsidiary of US based NAMSA (acquired in
2004) brings proven expertise in areas such as clinical studies and testing, safety
testing, and therapeutic value assessments of medical systems. The company
also provides microbiological testing services and training for manufacturers
and surgeons.
NAMSA is the world’s leading CRO, providing a broad range of services to
medical equipment manufacturers for over 45 years. The company delivers
particular expertise in product safety testing, clinical research, and regulatory
compliance.
In Ovo, ultra-sensitive in vitro testing
In Ovo develops and sells the world’s only ultra-sensitive early tests capable of
simultaneously measuring potential drugs’ efficacy and toxicity before animal
or human trials are performed. The tests use the embryonic eggs of chickens,
amniotes similar to mammals, to provide a faster, more complete, more reliable,
and less costly method of testing than current models can offer.
AEPI - MedTech 2014
7
Computer-assisted medicine
and surgery
T
oday’s hospitals are equipped with advanced technical facilities that use robotics
and digital imaging to deliver improved patient care. Most notably, today’s “hightech” medical systems help surgeons perform more precise, less invasive, and safer
procedures for better patient comfort and clinical outcomes. Computer-assisted
medicine and surgery covers technologies such as medical and surgical robotics,
surgical navigation, and simulation.
F
or more than 25 years, the Grenoble area has stood out for groundbreaking
R&D partnerships involving clinicians, research scientists, and manufacturers.
Their exemplary teamwork has resulted in the emergence of innovative medical
systems that give surgeons immediate information about their patients during a
procedure and guide them during complicated procedures, among them biopsies
and prosthesis implantation, making those procedures safer. Tens of thousands of
patients have already benefitted from medtech advances developed by researchers
at Grenoble labs such as TIMC-IMAG, a joint lab of Joseph Fourier University and
CNRS (see below), as well as Grenoble University Hospital Center clinicians, and
medical systems manufacturers.
E
CCAMI, the Excellence Center for Computer Assisted Medical Intervention,
was founded in 2010 to bring together clinicians, research scientists, and
manufacturers from across the Rhône-Alpes region. CAMI, which received funding
under France’s national LabEx program, unites six joint academic research labs
from across France for partnerships with clinicians and manufacturers. The goal
is to develop innovations that are medically effective, economically viable, and
widely adoptable.
TIMC-IMAG
advances
blends
clinical
and
technological
research
The applications-focused TIMC-IMAG lab studies medical imaging techniques
from an IT and mathematics angle. It is a joint research unit of Joseph Fourier
University (UJF) and the French National Center for Scientific Research (CNRS).
Scientific researchers and clinicians work together on ways to use IT and applied
mathematics to better understand and control normal and pathological processes
for biology and healthcare. The lab’s multidisciplinary research helps further
scientists’ basic knowledge of these topics and fuels the development of new
systems for both diagnostic and therapeutic medicine.
The lab’s computer-assisted medicine and surgery team, set up in 1985, has
pioneered advances in medical and surgical robotics and instrumentation,
for example. Most of the team’s research is conducted in partnership with the
Grenoble University Hospital Center and, especially, the center’s CIC-IT unit (see
page 7).
TIMC-IMAG is also very active in technology transfer and has spun off eighteen
start-ups, including Endocontrol and Koelis.
8
AEPI - MedTech 2014
Grenoble-Isère, where
pioneering innovations are born
A visionary center dedicated to innovation enhancement
ECCAMI (the Excellence Center for Computer Assisted Medical Interventions)
supports the emergence of new technologies and their transfer to medicalsystems manufacturers. The center, founded in 2010 by Joseph Fourier University
and Grenoble University Hospital Center, brings together clinicians, scientific
researchers, and manufacturers. The center’s 30 members include Inria, CEA-Leti,
CNRS, Grenoble Institute of Technology, Thales, and around 20 innovative startups. The center’s activities cover all aspects of medicine—surgery, interventional
radiology, radiotherapy, clinical assistance, and more— that could benefit
from computer assistance, with techniques ranging from surgical robotics and
navigation to minimally-invasive surgery and healthcare information systems.
ECCAMI’s areas of expertise include 3D bone and organ models and databases,
software for computer-assisted medicine and surgery, sensors, interventional
imaging, mesh matching, in vivo tissue elasticity measurement, 3D modelling,
navigation, planning and simulation, medical robotics, image processing, and
data fusion.
The center’s resources were developed to support all stages of the technology
development and transfer process:
•Research labs within TIMC-IMAG
•Labs for testing on mannequins and anatomical specimens; access to hospital
departments
•A dedicated room in the Joseph Fourier University anatomy lab for
experimentation with anatomical specimens and validation of the design,
ergonomics, and fitness-for-use of medical devices developed by partner
manufacturers
•A technology showroom for computer-assisted surgery presentations and
demos.
Guiding the surgeon’s hand
EndoControl, founded in 2006, makes robotics systems for endoscopic surgery. The
company has leveraged strong research partnerships to develop compact, innovative
instruments that improve the ergonomics of minimally-invasive surgery. Vicky, the
company’s first robot, is voice controlled. It lets surgeons position an endoscope
during surgery without assistance. The company’s second product, Jaimy, released
in early 2014, replicates the movements of surgical instruments inside the patient
during minimally-invasive surgical procedures.
AEPI - MedTech 2014
9
Drug-delivery systems (DDS)
F
or the past two decades the advent of new therapeutic molecules and advances
in nanomedicine have fuelled the development of new drugs capable of targeting
very precise areas of the human body. To keep the active substances in these
drugs from losing their effectiveness before they reach the area to be treated,
more precise drug delivery systems are needed. Developing these systems requires
know-how from a wide range of disciplines, from mechanics and electronics to
chemistry and materials. And, increasingly, these drug delivery systems draw on
the latest innovations in digital, micro-, and nanotechnologies.
G
renoble-Isère is a hub for cutting-edge developments in drug delivery systems;
the region is home to market leaders, among them Becton Dickinson, Fresenius
Kabi, and Nemera (formerly Rexam Healthcare), which develops and manufactures
its insulin pens locally. In addition to these major players, Grenoble-Isère also
boasts a slate of dynamic small businesses such as Eveon, which has successfully
harnessed local know-how in micromechanics, mechatronics, electronics, and
MEMS (microelectromechanical systems). Eveon worked with CEA-Leti for three
years to develop the first silicon “smart drug delivery” micropump using standard
MEMS fabrication processes. The system’s high volume and extreme precision will
cut injection times and improve patient comfort, and, because less of the drug is
wasted, it will also save money. Eveon’s drug delivery system is a prime example
of how healthcare professionals, major research centers, and academic labs can
combine their complementary know-how to get new innovations to patients faster.
Becton Dickinson: An active contributor to Grenoble’s
economy for over 50 years
Becton Dickinson (BD) is one of the world’s leading medtech companies. It
designs, manufactures, and markets medical systems, testing instruments, and
medical reagents. BD first set up operations in France in 1958. Nearly 1,600
people work at the company’s site in Pont de Claix. All of BD’s global business
segments (BD Medical, BD Diagnostics, and BD Biosciences), business units, and
corporate functions are represented at the Pont de Claix site.
A large part of the company’s injectables business is run out of the Pont de Claix
site, which is also home to a prefillable glass syringe production unit (for the
BD Medical segment’s Pharmaceutical Systems division). The Pont de Claix site
has earned recognition for innovation and high-added-value manufacturing. The
company invests nearly €20 million per year (2011–2015) to keep the site’s
manufacturing equipment at the industry’s state of the art.
10
AEPI - MedTech 2014
Getting treatments to their target
IV equipment design and manufacturing specialist
Fresenius Kabi brings more than 30 years of experience in designing and
manufacturing IV equipment. The company’s comprehensive lineup of syringe
pumps, IV pumps, and IV stations covers the full spectrum of hospital needs,
from general to specialized care units in addition to ICUs and operating rooms.
The company leverages know-how in electronics, IT (embedded and systems),
and mechanics to develop products for IV anesthesia, intensive care, and other
hospital applications, as well as homecare. Fresenius Kabi’s Brézins site in Isère
counts 400 employees, serves as the company’s global competency center for IV
and nutrition equipment, and is home to three divisions:
• R&D and manufacturing
• Commercialization
• Strategic marketing
Breaking new ground in smart drug injection systems
Eveon, based in Montbonnot near Grenoble, designs, develops, and assembles
completely-automated drug preparation and delivery systems (by nebulization,
spray, or injection). The company custom-develops and manufactures its products—
from the reconstitution of lyophilized drugs to the injection of viscous drugs—in
association with pharmaceutical and biotech companies. Eveon’s systems are
based on three major innovations:
•Suitability for all types of primary containers (vials, cartridges)
•A micropump to control drug preparation (lyophilized drugs, liquid-liquid
blends, etc.) and inject drugs with precision volumes from the μl to the ml
scale
•Integrated skin, fluid, air, and pressure sensors that control all drug
preparation and injection parameters
Eveon recently formed a partnership with Alaxia, a biotechnology company that
develops new treatments for the most serious respiratory diseases, to create a
home-based production system for use in treating cystic fibrosis.
The new partnership, which follows Eveon’s 2012 acquisition of Alpao, a maker
of deformable mirror and adaptive optics, brings Eveon additional know-how in
imaging for diagnostics and firmly positions the company in the vision sciences.
AEPI - MedTech 2014
11
Bioinformatics and healthcare
information systems
T
he growing complexity of medicine is in step with the increasing performance
of information technology. For applications spanning diagnostics, imaging,
genomics, complex biological systems, and personalized medicine, today’s
information systems must cope with massive amounts of data—requiring unique
and innovative approaches to statistics and data processing. Solutions must be
found to standardize and store data so that they can be analyzed, tracked, and
shared—with the ultimate goal of helping caregivers more accurately diagnose
and treat patients.
A
nd the issues are many. How do you model medical knowledge? Or complex
molecules? How do you share medical data quickly, effectively, and securely?
How do you save and reuse data? Processing medical imaging data, presenting
patient data in a useable form, and modeling biological interactions are just some
of the many challenges this highly interdisciplinary field is tackling.
H
ealthcare information systems must do more than just process large amount
of data; to add value to medicine, they must also provide new analytical models
and compare them with the results of medical experiments. And Grenoble-Isère is
home to a host of professionals poised to provide relevant solutions.
Landocallabs),software
makers such as Technidata (software for biology resource centers
EquiTime (healthcare staff schedule management software), and Alma
(which developed a software suite for hospitals in partnership with Grenoble
University Hospital Center), are helping pioneer advances.
Excellence in digital research
Inria Grenoble-Rhône-Alpes (France’s National Institute for Research in Computer
Science and Automation), founded in 1992, boasts 34 research teams and
employs 610 people. The institute is a leading R&D center for simulation, image
interpretation, modelling, data processing and representation, distributed and
high-performance computing, and modelling complex phenomena. Inria has spun
off 23 start-ups since 1998 and is involved in R&D projects coordinated by four
clusters, including Minalogic and Lyonbiopôle. A half-dozen research teams at
the institute are working on multidisciplinary projects combining IT and healthcare
and that cover a broad range of topics from evolutionary biology to drug efficacy.
12
AEPI - MedTech 2014
Software to power medtech solutions
Biological data analysis software and services
Genostar provides a comprehensive range of bioinformatics and database solutions
for microbial (viruses, bacteria, and yeasts) genome, transcriptome, protein, and
metabolic analysis. The company also offers bioanalysis services encompassing
genome sequencing, annotation, and comparison, as well as raw data assembly.
Genostar’s software and databases are available via an integrated platform for a
seamless microbial genome analysis and comparison workflow.
IT solutions for testing labs
Software developer Technidata is based in Montbonnot, just outside of Grenoble.
The company develops IT solutions for biological resource centers and labs,
offering a full range of lab and biobank management software, as well as a
comprehensive lineup of services from consulting and project management to
custom software development, training, and technical support. The company’s
products are sold in more than 25 countries, where they are used in fields such
as biochemistry, hematology, immunology, serology, virology, microbiology,
molecular biology, genetics, anatomo-cytopathology, and biobank management.
A global expert backed by local center of excellence
Persistent Systems, founded in 1990, is a global leader in software and IT
services, in particular for life sciences and healthcare applications. The company’s
Life Sciences Division targets the analytical chemistry instrumentation, LIMS,
bioinformatics, medical device, clinical trial database, e-healthcare, and care
management markets. In 2011 the company acquired Agilent Technologies’
center of excellence, which today employs around 40 people.
The specialist in shared patient medical files
Calystene, founded in 1992, develops medical and administrative IT solutions for
streamlined business processes, increased compliance with procedures, broader
information sharing, and more secure care processes. The company has built up
more than 20 years of experience and is today recognized as an expert in shared
patient medical files, nominative drug prescription and dispensation, healthcare
procedures, and secure drug circuits, as well as in the technical management
of rehabilitation, imaging, and specialist practitioner units in conjunction with
hospitals.
AEPI - MedTech 2014
13
Medical imaging
D
emand for medical imaging services is on the rise. Recent technological
advances have made medical imaging a powerful tool for exploring the human
body—and the key to widespread deployment of personalized medicine. Medical
imaging, when combined with a patient’s biological data, can make the difference
in terms of early diagnosis and more individualized, better targeted treatment.
M
olecular imaging lets us actually see cells and molecular processes at work.
And the technology is driving advances in patient care—particularly in oncology,
where it is helping doctors diagnose tumors earlier and more precisely, administer
more targeted treatments, and assess the efficacy of a drug instantaneously. And,
thanks to companion tests and biomarkers, molecular imaging can even be used
to predict and validate the efficacy of a drug’s active ingredient, making it a useful
tool along the entire medtech value chain, from basic research and new drug
development to patient care.
M
edical imaging professionals are currently restructuring their resources to
adapt to the challenges that will be posed by new medical treatments stemming
from today’s biotech research. An ever-broadening field of investigation spanning
molecular and cellular biology has paved the way for developments such as
tracers specific to certain diseases, for example, those used in Fluoptics’ optical
imaging system for cancer surgery, which has just obtained FDA approval for the
US market.
G
renoble-Isère is home to a number of companies that have risen to global
leadership positions in certain segments of the medical imaging market. Trixell,
based in Moirans, near Grenoble, is the world’s leading manufacturer of digital
detectors for medical radiology; e2v designs and manufactures a line of sensors
for digital radiographic imaging—used in dental diagnostics—at its plant in SaintEgrève, also near Grenoble.
The FLI-Grenoble network of excellence in biomedical imaging
FLI (France Life Imaging) is a national research network focusing on biomedical
imaging. The network aims to push back the frontiers of today’s in vitro imaging
technologies, develop a unified line of superior-quality services, and raise France’s
profile in this dynamic industry.
The national network is made up of six regional branches, one of which is in
Grenoble. FLI-Grenoble was created from a partnership between Joseph Fourier
University, the French National Center for Scientific Research (CNRS), Inserm,
Grenoble University Hospital Center, CEA-Leti, and ESRF. It brings together
chemists, physicists, engineers, technology experts, biologists, pharmacists, and
MDs specializing in preclinical and clinical research in in vivo imaging.
The network boasts a broad range of equipment covering all types of imaging
(MRI, pre-operative MRI, nuclear imaging, optical imaging, intravital microscopy,
MEG/EEG for neurophysiology, and monochromatic X-ray) and offering levels of
performance that exceed what is currently available on the market.
14
AEPI - MedTech 2014
Fuelling the expansion of personalized
medicine
Innovative fluorescence imaging for surgery
Fluoptics has developed an in vivo optical imaging system (Fluobeam®) and a
fluorescent tracer (Angiostamp™) with tumor-targeting capacities. When used
together, the two products let surgeons see actual biological processes and
cancer cells that would be invisible to the naked eye in real time during a surgical
procedure. That means doctors can identify a tumor’s edges with a great degree
of precision, reducing the risk of damaging healthy tissue or leaving cancerous
cells behind. The result is fewer relapses. The company was founded in 2009 to
develop and market instrumentation technology invented in CEA-Leti’s labs. The
technologies that underpin Fluoptics’ tracer were developed at Joseph Fourier
University in conjunction with the CNRS and Inserm.
The global leader in digital detectors for medical imaging
Trixell, founded in 1997, is a joint venture between Thales Electron Devices, Philips
Healthcare, and Siemens Healthcare (all three of which are global leaders in
diagnostic and surgical systems). Trixell designs and manufactures flat-screen
digital detectors, using a technology that leverages the company’s own sensors
to convert X-rays to digital signals. The system can be used in a broad range of
medical radiology applications. In addition to helping reduce the X-ray dosages
to which patients are exposed, the technology helps improve diagnostics. Most
notably, the technology facilitates the transmission and storage of X-ray images
and is compatible with a broad range of image-processing techniques. Trixell is
located in Moirans, near Grenoble.
One of the world’s leading manufacturers of medical imaging
equipment
The American GE Healthcare (European HQ in UK), is one of the world’s leading
manufacturers of medical imaging equipment. The company stands out for its
extensive range of products and services, which, in addition to medical imaging
equipment, also include new drug development and biopharmaceutical product
manufacturing. GE Healthcare’s mission is to speed the development of tomorrow’s
medical technologies and revolutionize healthcare by helping researchers identify
and better understand disease—and doctors better diagnose and treat patients.
Thomson CGR, located in Isère since 1975, became GE Healthcare in 1990. The
company’s technologies and services for healthcare professionals are intended to
improve the use of medical imaging equipment, medical diagnostics, and patient
management systems.
AEPI - MedTech 2014
15
Medical diagnostics
T
he medical diagnostics market is undergoing unprecedented change due to
by the advent of personalized medicine and the emergence of new testing-lab
business models. This transformation is further accentuated by the relentless quest
for efficiency in healthcare systems and individualized treatments that draw on
increasingly large amounts of data. In this landscape, manufacturers must ensure
that their medical diagnostic systems meet healthcare professionals’ needs for
increasingly precise results. Sample sizes are shrinking (often around a microliter),
biochips are becoming increasingly common, readers are now pocket-sized, and
labs are integrating advances in microfluidics and nanotechnologies—many of
which were invented in Grenoble.
G
renoble-Isère is home to some of the world’s leading names in medical
diagnostics (Roche Diagnostics and bioMérieux), major research centers (CEA),
and vibrant start-ups (Avalun, ImmunID, and others). In addition, internationallyrecognized synergies between publicly-funded research and private-sector R&D
have made Grenoble—and France’s entire Rhône-Alpes region—one of the
country’s major centers for the development and clinical testing of innovative in
vitro diagnostic systems. The Christophe Mérieux Center, born from over a decade
of collaboration between bioMérieux and the CEA, is a prime example.
Immune-system profiling for personalized medicine
ImmunID, spun off of a CEA-Grenoble lab in 2005, specializes in molecular
diagnostics of the immune system for the pharmaceutical and medical diagnostics
markets. The company develops products and services for testing the immune
repertory at genome level. ImmunID’s tests measure a patient’s immune defenses
and provide additional insight to help caregivers deliver personalized treatments.
The company’s technology was first used to monitor patients during cancer
treatment.
A pocket-sized lab
Avalun, a recent spin-off of CEA-Leti, is developing a portable in vitro diagnostic
system that can perform multiple biological tests simultaneously. The system is
designed for healthcare professionals and patients seeking to play a more active
role in their own care. At its core is the LabPad® reader—poised to ride the growing
trend toward e-healthcare—and a range of consumables that professionals and
patients can use to perform various tests from a single drop of blood.
16
AEPI - MedTech 2014
Home to global leaders
and innovative start-ups
Developing tomorrow’s diagnostics’ solutions in Grenoble
A leader in in vitro diagnostics and infectious diseases, bioMérieux was founded
in 1963 and now operates in more than 150 countries. Today, the company is
renowned for its know-how in clinical diagnostics and industrial microbiological
quality control testing. The company’s strategy is driven by technological and
scientific innovation and is backed by heavy investment in R&D programs run by the
company’s own multidisciplinary staff, with the support of numerous international
partnerships and alliances. For example, bioMérieux has been working with CEALeti since 1997 through a joint multidisciplinary team to develop innovative in vitro
diagnostic systems. In 2006, the company located its Christophe Mérieux Center
for Molecular Biology in Grenoble, near the CEA and MINATEC campuses.
bioMérieux has two sites in Grenoble-Isère:
•The Christophe Mérieux Center in Grenoble, which employs nearly 200
people and is home to the company’s molecular biology activities. It houses
a state-of-the-art research unit comprising chemistry, biology, molecular
biology, and systems engineering labs. The site also has a production unit
dedicated to manufacturing and improving reagents.
•The company’s center for expertise in microbiology, which employs
more than 400 people, including more than 200 research scientists in
microbiology, engineering, and IT. The center is located in La Balme les
Grottes.
The global leader in histopathological diagnostics
Roche is the world’s leader in in vitro diagnostics and histological cancer
diagnostics, and is paving the way to major innovations in diabetes management.
Roche Diagnostics France, a Roche subsidiary entirely dedicated to diagnostics, is
France’s number-one biological diagnostics company. Headquartered in Meylan,
near Grenoble, since 1977, Roche Diagnostics France employs 650 people and
markets a comprehensive lineup of products and services for research, biological
testing, histopathology, and diabetes. Roche Diagnostics France acquired USbased Ventana Medical Systems in 2008, propelling the company to its current
position as a global leader in histopathological diagnostics. The company’s
Meylan site is home to its diabetes, medical biology, and research business lines,
as well as its international customer support and training centers.
AEPI - MedTech 2014
17
The silver economy
T
he world’s population is aging: by 2035, senior citizens will make up a third
of the people on the planet. This huge demographic shift is at the root of major
societal and economic transformations, and developed countries are on the front
lines. They must now rapidly adapt their public healthcare systems to survive
in this new environment. However, the “silver economy” will also present new
opportunities. The demand for assisted living solutions will mushroom, creating
a high-potential new market. Research firm HIS forecasts that the global in-home
healthcare market will double over the next six years, soaring from €5.7 billion in
2013 to €12.8 billion in 2018.
A
nd with that opportunity comes challenges such as how to improve treatments,
shorten hospital stays, mitigate the risks associated with elderly patients living
alone, and ensure that medical care is available in rural and other underserved
areas. More comprehensive in-home care, better coordinated medical and social
services, improved safety, and solutions for independent living are just some of the
goals that scientists are striving to reach. And digital and “geron-” technologies
will play a pivotal role by driving advances in remote patient monitoring and
diagnostics—both of which will help improve the quality of care and reduce the
number of hospital stays.
Imany
mproving the healthcare continuum is now a healthcare policy priority in
countries. To rise to this challenge, both human and technical resources
will need to be deployed, both in patients’ homes and remotely. In Isère, local
governments are backing a variety of e-healthcare programs, one of which is the
Autonom@Dom® independent living program spearheaded by the Isère General
Council.
G
renoble-Isère is known as a hub for science and technology. However, it
is also an ideal proving ground for experimental initiatives to develop the
technology and processes needed to meet the growing demand for in-home
healthcare and assisted living solutions. Local nonprofit organizations TASDA and
Medic@lps, the regional I-Care cluster, and global competitive clusters Minalogic
and Lyonbiopôle play a crucial role liaising with and rallying local experts around
these emerging issues.
Autonom@Dom®, a living lab for an enhanced patient care
continuum
The Autonom@Dom® program consists of an integrated healthcare and social
services portal offering a range of services available 24 hours a day, seven days
a week, in addition to personalized human assistance and technical solutions—
all designed to enable in-home care. The program aims to break down the silos
that currently separate healthcare and social services for an enhanced patient
care continuum, particularly for the elderly in need of assisted living solutions
and people with chronic disease. Some 800 people will receive services over the
two years of the program. The goals are to assess changing business processes
in healthcare and social services, evaluate integrated technical solutions and the
associated business models, and eventually deploy the program locally, nationally,
and perhaps even internationally.
18
AEPI - MedTech 2014
Local stakeholders leading the way
Coordinating partnerships to conceive tomorrow’s assisted
living services
TASDA, a nonprofit organization focusing on in-home healthcare and assisted
living, was founded by the Grenoble University Hospital Center, Minalogic,
and local governments. It is an “expert” member of France’s national center for
in-home healthcare and assisted living. TASDA’s role is to liaise between in-home
healthcare and assisted living stakeholders, from solutions providers, healthcare
and social services professionals, and academics to subsidized housing providers,
government agencies, financers, prescribers, and users. In practical terms,
TASDA provides businesses and local governments with insights into tomorrow’s
healthcare needs, the technological solutions in the pipeline, and knowledge of
the stakeholders and markets involved.
Digital technologies for the elderly
Technosens, founded in 2007, develops and markets a simplified multimedia
communication system called e-lio. This interactive system is designed to keep the
elderly in touch with family members and healthcare providers through a video
sensor and a user-friendly combined telephone handset/remote control unit. The
system provides an easy-to-use videoconferencing experience right on the user’s
TV screen. Users can receive messages, photos, and videos and access a range of
services including meal delivery, home automation, entertainment, fall prevention,
and more—right from their homes.
Smart biodetector makes independent living safer
Vigilio, founded in 2005, develops systems capable of distinguishing normal
everyday situations from critical situations requiring emergency assistance. The
company’s Vigi’Fall™ fall detection unit consists of a biosensor equipped with
radio communication capabilities, a body patch worn by the user, sensors, and
a control center.
Complete remote patient monitoring services
H2AD® operates and manages a complete range of around-the-clock remote
healthcare and patient monitoring services. The company located to Grenoble
in July 2013 to be near the city’s research centers, and today offers continuous
remote patient monitoring systems that combine human resources (a call center)
and technical capabilities (communicating scales, remote activity monitoring, and
more) to follow-up on inpatient care once patients are released from the hospital
and to monitor patients suffering from serious chronic diseases.
AEPI - MedTech 2014
19
Medical research and
innovation
Grenoble-Isère boasts a thriving scientific community poised to respond to the
major challenges facing the life sciences and healthcare sectors. Whether for
basic or clinical research, local businesses have access to major international
scientific research instruments and a broad range of laboratories. And, in
Grenoble-Isère, opportunities to work with leading scientists through R&D
partnerships abound. Manufacturers have partnered with Grenoble University
research labs, the Grenoble University Hospital Center (via CIC-IT Maxithec),
local branches of the French National Center for Scientific Research (CNRS),
the CEA, Inserm, and Inria, to name a few. The region is home to some 200
research teams working on computer-assisted medicine and surgery, micro- and
nanotechnology for medicine (local researchers file more than 40 patents in this
burgeoning field each year), in vitro diagnostics and medical imaging, new
materials, tissue engineering, bioinformatics, healthcare information systems,
and e-healthcare.
T
he local research ecosystem is anchored by R&D centers at the leading edge
of medicine and some of the world’s largest scientific instruments for observing
matter. EMBL (the European Molecular Biology Laboratory), IBS (Institut de
Biologie Structurale), Institut Albert Bonniot (for research on molecular oncogenesis
and ontogenesis), GIN (Grenoble Neuroscience Institute), Institut Jean Roget
(for genomics research), ILL (Institut Laue Langevin), and ESRF (the European
Synchrotron Radiation Facility)—along with active academic research—fuel
Grenoble-Isère’s capacity to conduct innovative, multidisciplinary work in the
field of healthcare. ESRF, a member of the Structural Biology Group, possesses a
dedicated beamline for medical research to characterize matter and materials of
all types, including biological tissues and molecules.
O
f course, the presence of leading international labs is just the beginning. The
region’s attractiveness also hinges on its multiple R&D partnerships and medtech
industry organizations and facilities that foster networking and pool research
and development resources (such as open-access labs, clusters, and professional
associations). All of these advantages help drive business competitiveness and
move the medtech industry forward.
Medic@lps, Founded in 2002, the Grenoble-Isère healthcare
cluster counts 70 members including start-ups, SMBs, corporations, research
centers, universities, and local governments, all united in their commitment to
developing medical technologies, biotechnologies, and e-healthcare technologies.
Medic@lps is uniquely positioned to serve businesses, with a management board
made up mostly of entrepreneurs. The cluster’s programs—group services and
individual assistance—are designed to support its members’ growth in a given
industry. And, with a vast network spanning the globe (including a shared office in
Boston), Medic@lps is poised to help its members penetrate international markets.
20
AEPI - MedTech 2014
A unique ecosystem
The global competitive cluster Minalogic, founded in Grenoble
in 2005, counts 236 members specializing in micro and nanotechnology
and digital solutions. Minalogic has set up a healthcare workgroup with around
40 active members. The group’s aim is to give businesses and research labs an
opportunity to share knowledge in four main research and development areas: :
•Instrumentation for research, diagnostics, and personalized medicine
•In-home healthcare and assisted living, shared patient medical files
•Augmented medicine and computer-assisted medicine and surgery
•Technical assistance and substitution systems, implanted systems
The cluster has certified and helped secure financing for around ten R&D projects in
remote healthcare, medical imaging, assisted surgery, miniaturized pacemakers,
and the development of microsystems to deliver drugs’ active ingredients.
Lyonbiopôle, another of the region’s global competitive
clusters, focuses on infectious diseases in humans and animals from a
holistic perspective, from diagnostics and prevention to treatment and treatment
administration systems. The projects certified by the cluster aim to develop
innovative diagnostic, preventive, and therapeutic medical advances and the
associated administration systems, with the overall goal of making medicine
more responsive and personalized. The target markets are: infectious diseases,
cancer, autoimmune diseases, rare diseases, inflammatory diseases, and more.
Lyonbiopôle has 139 members and has certified 145 R&D projects since 2005,
for total R&D spending of €710 million, €285 million of which was governmentfunded.
The I-Care cluster brings together stakeholders from across the medtech value
chain and throughout the Rhône-Alpes region. The cluster’s mission is to support
businesses in their implementation of innovative strategies to respond to changing
markets and improve their business environment, making them more competitive.
Members include businesses, universities, research centers, healthcare facilities,
and nonprofits.
AEPI - MedTech 2014
21
Medical research and
innovation
Clinatec is a cross-disciplinary applied medical research
center, spearheaded by internationally-renowned neurosurgeon Dr. Alim-Louis
Benabid, 2014 Lasker-DeBakey Clinical Medical Research Award. Located on the
MINATEC innovation campus, Clinatec aims to develop and test innovative medical
treatment strategies leveraging the latest advances in micro- and nanotechnology
and electronics. The center, an initiative of CEA-Leti in partnership with Grenoble
University Hospital Center, Joseph Fourier University, and Inserm, is unlike any
other medical research center in the world. It aims to respond to major biomedical
needs in the treatment of cancer, neurodegenerative diseases, and spinal-cord
injuries. Clinatec houses a range of joint R&D projects involving academic
research labs and manufacturers, in order to forge the necessary synergies among
clinicians, engineers, and biologists.
Around €40 million was invested to build the 6,000 m² Clinatec facility, which
boasts preclinical research labs, biology labs, and a pilot hospital unit with six
patient rooms, a post-surgical recovery room, and an operating room equipped
with the latest technology such as a neurosurgery robot and intraoperative MRI.
One of Clinatec’s flagship projects is a brain-controlled exoskeleton to help
quadriplegic patients regain the use of their limbs. The system is directly implanted
in the patient’s cranium, on the surface of the motor cortex, eliminating the need
to implant electrodes in the patient’s brain. Its 64 sensors capture the motor cortex
signals generated by the patient’s intent to move. Ultimately, the implantable
system will be used to operate a new generation of exoskeleton developed by
CEA-List researchers at a lab in Grenoble. The exoskeleton R&D project also
involves developing software to decode brain signals and transform them into
movements.
22
AEPI - MedTech 2014
A unique ecosystem
The NanoBio innovation center was launched in 2001 by CEA-Grenoble,
Joseph Fourier University, and Grenoble University Hospital Center. It houses
scientific equipment for research in micro- and nanotechnology for biology and
healthcare applications. Professionals from research (more than 300 scientists
in chemistry, physics, materials, biology, medicine, and electronics), higher
education, and industry work together interactively via the center to pursue two
objectives:
• Design and develop new miniaturized systems to improve testing, diagnosis,
and treatment of numerous diseases
• Promote the dissemination of new knowledge in the life sciences and
healthcare and transfer that knowledge to industry
NanoBio focuses mainly on active wearable and implantable medical systems,
with:
•Labs-on-chip
•Active wearable medical systems
•Cell architecture research
•A proteomics resource center
•Biochips and functional genomics.
NanoBio leverages all of the advantages of the MINATEC innovation campus,
including expertise in micro- and nanotechnology and infrastructure featuring
the High-Tech Building (BHT), which houses high-tech companies on the campus.
NanoBio also draws on the nearby Clinatec applied medical research center
and Grenoble University Hospital Center, where preclinical and clinical trials are
performed.
Biopolis is a business incubator and resource center coordinated
by Joseph Fourier University. It provides office and lab space and support services
to innovative young companies entering the healthcare market. The incubator
boasts 2,000 m² of facilities, including 27 offices available for lease and 12 lab
rooms. It is conveniently located in a medical park next to Grenoble University
Hospital Center, the Institut Albert Bonniot (IAB), and IN3S (the Institute for
Healthcare IT and Engineering).
The ground floor is dedicated to dry biology research (medtech, robotics, and
software) and has a microscopy room and microsystems labs. The wet biology
lab, upstairs, offers molecular biology and biochemistry labs, a P2 lab, two cell
culture labs, a fully-equipped washing and sterilization room, and machine room.
Businesses, whether in the early start-up phase or already established, can access
a full range of technical and administrative support services and enjoy close
proximity to research centers (Grenoble University Hospital Center, ECCAMI,
Joseph Fourier University, and others) and other companies. They also benefit
from an environment that facilitates experimentation and navigation through the
different phases of the start-up process, from the validation of new technology to
prototyping.
AEPI - MedTech 2014
23
Higher education
One of Europe’s biggest college
towns
61,300 students
7,200 international students
4 universities
7 engineering schools
29 engineering majors
265 Master’s degree programs
14 doctoral schools
renoble-Isère is home to more than 61,000 students, making it one of
G
France’s biggest University towns. With a wide variety of top-quality degree
programs (particularly in the sciences, in which 42% of the city’s students are
enrolled), Grenoble’s universities benefit from a strong international reputation—
reflected in the 7,200 international students from 180 different countries who
study here. Local life sciences and healthcare-related degree programs enroll
some 9,000 students (mostly at Joseph Fourier University).
D
egree programs in the life sciences and healthcare-related disciplines
are continuously updated to meet the rapidly-changing needs of research
organizations and businesses operating in this fast-paced sector. Over the past
two decades, Grenoble University has pioneered advances in France’s medicalschool landscape, developing integrated university-hospital programs, clinical
internships, and cross-disciplinary curricula.
G
renoble’s institutions of higher learning have developed numerous programs
to meet the unique needs of the medtech industry. These multidisciplinary
programs stand apart in that they address both the scientific and industrial
aspects of medical technologies.
Doctoral schools
•Chemistry & Life Sciences (EDCSV)
The Doctoral School for Chemistry & Life Sciences is known for its sharp focus on activities at
the crossroads of disciplines such as biology, chemistry, medicine, pharmacy, and physics, with
a particular emphasis on highly-interdisciplinary experimental approaches. The school boasts a
number of different labs in and around Grenoble that conduct high-profile research in cellular
and molecular biology, structural biology, molecular chemistry, and physical chemistry
•Engineering for Healthcare, Cognition, and the Environment (EDISCE)
The Doctoral School for Healthcare, Cognition, and the Environment specializes in data
acquisition, processing, and modelling to better understand the mechanisms at work in living
systems, examining their relationship to their environment, cognition (perception and decision),
and action (control and effectuation).
24
AEPI - MedTech 2014
Multidisciplinary programs designed to
meet medtech industry needs
Joseph Fourier University, offering programs in the sciences,
technology, and healthcare
The Joseph Fourier University regularly appears in all of the major international
rankings. It boasts a student body of more than 17,000, as well as fourteen
academic departments in Grenoble and an extension campus in Valence. As part
of its mission to prepare students for the major healthcare challenges of tomorrow,
the university offers both general and highly-specialized degree programs.
• Medicine and pharmacy
The university’s programs in medicine and pharmacy (5,000 students) stand out
for their innovative teaching and exceptionally enriching scientific environment.
• Healthcare information systems engineering
The university’s program in healthcare information systems engineering was first
launched ten years ago at Polytech Grenoble (the Joseph Fourier University’s
engineering department) in association with Grenoble University Hospital Center
and research lab TIMC-IMAG. The program prepares tomorrow’s engineers to
interface between healthcare, IT, and instrumentation, with courses in signal and
image processing and clinical measurement, for example.
• Engineering for healthcare and drug development
This Master’s program offers eight specializations spanning medtech, pharmacy,
biotech, and the relationships between healthcare and the environment. It prepares
budding scientists, engineers, doctors, project managers, and clinical research
associates to develop and test technological innovations leveraging healthcare
information systems, modeling, and medical imaging.
• International program in biohealth computing
This Erasmus Mundus program, offered at the Master’s and Ph.D. levels, prepares
tomorrow’s healthcare-industry executives to support multidisciplinary research
programs combining biotechnology, clinical research, environmental health, and
mathematical modeling.
Grenoble Ecole de Management
Biotechnology Management
(GEM)
Master’s
in
This program was developed in 2002 to meet the growing demand in the life
sciences industry for multidisciplinary competencies in biomedical science and
management. Students who complete the program come away with a strong
scientific background (Ph.D.; Pharm.D.; MSc in biology or chemistry, for example)
as well as solid business skills suitable for positions such as product manager,
marketing manager, IP consultant, technology transfer manager, and business
developer.
AEPI - MedTech 2014
25
26
AEPI - MedTech 2014
Development opportunities
for all medtech stakeholders
MEDTECH INDUSTRY CHALLENGES
T
he medtech industry is currently facing a number of
challenges, from discovering new, more effective, and
better targeted molecules to developing complete
therapeutic systems encompassing diagnostics, data
analysis, treatment selection, drug delivery, and services
for patient monitoring and assisted living.
New
opportunities
technologies
for
digital
Iknow-how
n addition to offering a level of technological
unrivalled in Europe, Grenoble-Isère is
also one of the only places in the world where a truly
multidisciplinary approach to scientific research is
used to develop miniaturized medical systems, innovative
diagnostic tools, surgical robots, and groundbreaking
imaging equipment. The area is also located near Lyon,
a pharmaceutical-industry hub, and a thriving plastics
industry in and around Oyonnax.
P
layers from the micro- and nanotechnology
and digital industries—both labs and manufacturers—
are driving the emergence of innovative new medical
applications for existing technologies and, in some cases,
new medtech products. The advanced technologies being
developed in Grenoble-Isère in fields such as electronics,
microsensors, software, and robotics, to name a few, are
boosting the added value of medtech solutions.
D
igital technologies are fuelling the growth
of in-home healthcare and assisted living
services—and Grenoble-Isère is leading the way. For
instance, Ivès is a company that develops and implements
remote healthcare services for the hearing impaired and
the dependent individual. And Orange Labs in Meylan,
near Grenoble, coordinates Orange’s innovation-related
activities in the field of e-healthcare.
The company also supplies high-security microprocessors
for tomorrow’s personalized healthcare cards. Movea, a
spin-off of CEA-Leti, is the global leader in motion sensing
technology for medical applications. Memscap provides
Carmat with pressure sensors and accelerometers for
the company’s autonomous artificial heart. And Maatel,
an electronics engineering and scientific instrumentation
firm, designs and manufactures medical electronics (for IV
automation, diagnostics, and electrosurgical equipment).
S
ensor miniaturization and innovations in
micro-energy sources like batteries and micro-fuelcells are now opening up new possibilities for the design
of extremely compact diagnostic and measurement
devices. PaxiTech, which manufactures small fuel cells, is
working on a portable external energy source designed
specifically for the healthcare market. And the TIMC-IMAG
lab is developing another major innovation in the form of
an implantable biobattery that is charged by the glucose
produced by the human body.
A new source of growth for “traditional”
manufacturing industries
Itech
nnovation is not reserved for so-called highcompanies. Businesses in industries such as
plastics, for instance, are leveraging their know-how
and innovation capacity to conquer new markets. One
example is ARaymondLife, founded in 2007 by industrial
fastener manufacturer ARaymond as part of the company’s
efforts to diversify. This venture into the healthcare market
has spurred the company to develop innovative solutions
for pharmaceuticals and medical diagnostics—namely,
components for drug delivery systems and medical
packaging systems. Another example is Stiplastics, which
produces plastic packaging systems and pillboxes.
E
lectronics and embedded intelligence are
playing an increasingly central role in medical
systems. Grenoble-Isère has attracted a number of
companies seeking the know-how and talent needed to
carve out a position on this market. STMicroelectronics, a
major figure in the local innovation ecosystem, is placing
its bets on medical applications for its low-energy signal
processing, MEMS, sensor, and actuator technologies.
AEPI - MedTech 2014
27
A3 Surgical
www.a3surgical.com
Aatlantide
www.aatlantide.com
Abiolab
www.abiolab.fr
www.liquid-logic.com
Advicenne Pharma
www.advicenne.com
Aenova
www.aenova.de
Ahlstrom
www.ahlstrom.com
www.alliadis.com
Alma
www.alma.fr
Alpao
www.alpao.fr
Alpes Instruments
www.alpes-instruments.com
Alumed
www.alumed.fr
ARaymondlife
www.araymondlife.fr
Ardes
www.ardes-france.com
28
www.avalun.com
Basan France International Vwr Gp
www.basan.com
BD
www.bd.com
Beckman Coulter Genomics
www.beckmangenomics.com
Bellin Creation
www.bellin-creation.com
Bgene Genetics
www.bgene-genetics.com
Bio-Logic
www.bio-logic.info
BioMérieux
www.biomerieux.fr
Biotem
www.biotem.fr
Bizmedtech
www.bizmedtech.com
Blue Ortho
www.blue-ortho.com
Boiron Laboratoires
www.boiron.com
Cad4bio
www.cad4bio.com
Calystene
www.calystene.com
Ceies
www.ceies.fr
(Centre d'Etudes de l'Impact de l'Environnment sur la Santé)
Cellipse
www.cellipse.com
Cerp Rhin Rhône
www.cerp-rrm.com
Cezame Connexions
www.cezame-connexions.fr
Chabloz Orthopedie
www.chabloz-orthopedie.com
Climatic Entreprise
www.climatic-entreprise.com
Cogitop
www.cogitop.fr
Covidien Manufacturing Grenoble (Medtronic)
www.covidien.com
Creacell
www.creacell.com
AEPI - MedTech 2014
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Medical implants and prosthetics
Pharmaceuticals
Software
Wholesalers and retailers
•
•
Aryballe Technologies
Avalun
CRO
Engineering and
services
•
Alchimedics
Alliadis (Cofdsi)
Consumables
Bioinformatics
Facilities
Surgical robotics
Instrumentation
Medical
equipment and
instrumentation
•
•
Acom Sante
Advanced Liquid Logic France
Medical imaging
Diagnostics
Drug delivery systems
Medical equipment
Website
In Vivo
Company
In Vitro
Biotechnology
Grenoble-Isère medtech industrial actors
•
•
•
Cytoo
www.cytoo.com
Delta Consultants
www.delta-consultants.com
Deltalab
www.deltalab.fr
Demeure Orthopédie
www.demeureorthopedie.com
Deva Laboratoires
www.deva-lesemotions.com
Ecrins Therapeutics
www.ecrins-therapeutics.com
Endocontrol
www.endocontrol-medical.com
EquiTime
www.equitime.fr
Er2i Ingenierie
www.er2i.eu
Eras Labo
www.eras-labo.com
Eticeo Sante
www.eticeo.com
Eurofins Optimed
www.optimed.fr
Eveon
www.eveon.eu
Faure Qei
www.faure-qei.com
Fdi France Medical
www.fdifrance.com
Fei - VSG
www.vsg3d.com
Finorga - Novasep Gp
www.novasep.com
Fisher Bioblock Scientific
fr.fishersci.com/fr/
Fluoptics
www.fluoptics.com
Fresenius Kabi
www.fresenius-kabi.fr
Gambro Industries
www.gambro.fr
General Electric Medical Systems
www.gehealthcare.com
Genostar
www.genostar.com
Ghw - Mediplus
www.ghwgroup.fr
Gmg
www.gmg-injectionplastique.com
Habitat et Santé
www.habitatetsante.net
Helioscopie
www.helioscopie.fr
www.herboristerie-chartreuse.com
Imactis
www.imactis.com
IMeBio
www.imebio.com
ImmunID
www.immunid.com
Inlab Healthcare
www.inlabth.com
Inovo
www.tests-inovo.com
Interactivite Video Système-Ives
www.ives.fr
Irlynx
www.irlynx.com
Isis
www.isis-robotics.com
Jarmat - Adp Laboratoire
www.adplaboratoire.com
Kalys
www.kalys.com
Keystone Dental
www.keystonedental.com
Koelis
www.koelis.com
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Medical implants and prosthetics
Pharmaceuticals
•
•
•
Software
Wholesalers and retailers
CRO
Engineering and
services
Consumables
Bioinformatics
Facilities
•
Surgical robotics
Instrumentation
Medical
equipment and
instrumentation
Medical imaging
Drug delivery systems
Diagnostics
•
Hemosquid
Herboristerie Chartreuse
Medical equipment
Website
In Vivo
In Vitro
Biotechnology
Company
•
•
•
•
•
•
•
•
•
•
•
AEPI - MedTech 2014
29
Kowok Theragnostic
www.kowok-theragnostic.com
Lxrepair
www.lxrepair.com
Maatel
www.maatel.com
Maincare Solutions (ancien Mckesson)
www.maincare.fr
Manudo Médical - GP Fimodo
www.manudo.fr
Mape Rga
www.mape-rga.fr
Mba Consulting
www.mbaconsulting.fr
Medartis
www.medartis.com
Mellitech
www.mellitech.com
Meunier-Carus Médical
www.meunier-carus.com
Micropoint Bioscience
www.micropointbio.com
Microvitae Technologies
www.microvitae.com
Minitubes
www.minitubes.com
•
30
www.movea.com
Namsa
www.namsa.com
Nano-H
www.nano-h.com
Naturamole
www.naturamole.com
NatX-ray
www.natx-ray.com
Nemera (ancien Rexam Healthcare)
www.nemera.net
Nexus/Optim
fr.nexus-ag.de
Novacyl
www.novacyl.eu
Novitom
www.novitom.com
Ocp Répartition
www.ocp.fr
Odontec
www.odontec.fr
OMNIlife Science (ancien Praxim)
www.omnils.com
Orkyn’
www.orkyn.fr
Orthotaxy
www.orthotaxy.com
Patheon France
www.patheon.com
Pdc Line Pharma
www.pdc-line-pharma.com
Pharm’Depo
www.pharmdepo.fr
PharmUp
www.pharmup.fr
Promise Advanced Proteomics
www.promise-proteomics.com
PX'Therapeutics
www.px-therapeutics.com
Quarness
www.quarness.fr
Raumedic AG
www.raumedic.com
Rbi
www.rbi-instrumentation.com
Rbp Pharma
www.rbppharma.com
Rhône-Alpes Labo
www.rhonealpeslabo.fr
Roche Diagnostics France
www.roche-diagnostics.fr
RTD
www.rtdental.fr
AEPI - MedTech 2014
•
•
•
Medical implants and prosthetics
Pharmaceuticals
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Software
Wholesalers and retailers
•
•
•
•
CRO
Engineering and
services
Consumables
•
•
•
Bioinformatics
•
•
•
•
Facilities
Surgical robotics
Instrumentation
Medical
equipment and
instrumentation
•
Minmaxmedical
Movea
Medical imaging
Drug delivery systems
Diagnostics
•
Medical equipment
Website
In Vivo
In Vitro
Biotechnology
Company
•
•
Saphymo
www.saphymo.fr
Sensaris Cyberfab
www.sensaris.com
Shimitek
www.shimitek.com
Sleepinnov Technology
www.sleepinnov.com
Small Infinity
Smartox Biotechnology
www.smartox-biotech.com
Sober Laboratoire
www.sober.fr
Sobioda
www.sobioda.eu
Soframedical
www.soframedical.com
Softin Systèmes
www.softin.fr
Sorin Crm
www.sorin.com
Stabyl
www.stabyl.fr
Stanley Healthcare Solutions France
www.stanleyhealthcare.com
Stemcell Technologies
www.stemcell.com
Stiplastics
www.stiplastics.com
SurgiQual Institute
www.surgiqual-institute.com
Surgivisio
www.surgivisio.com
SynapCell
www.synapcell.fr
Synthelis
www.synthelis.fr
Technidata
www.technidata-web.com
Technosens
www.technosens.fr
The Binding Site Limited
www.bindingsite.com
Thierry Baboulin
www.baboulin.com
Thomassin Laboratoires
www.audition-thomassin.fr
Tornier
www.tornier.com
Toxibionte
www.toxibionte.fr
Trixell
www.trixell.com
Ugin Dentaire
www.ugin-dentaire.fr
Univéo
www.univeo.fr
UroMems
www.uromems.com
Valtronic
www.valtronictechnologies.com
Vigilio
www.vigilio.fr
X Medical Picture
www.xmedicalpicture.com
Xenocs
www.xenocs.com
•
Medical implants and prosthetics
Pharmaceuticals
Software
Wholesalers and retailers
CRO
Consumables
Engineering and
services
•
Bioinformatics
Facilities
Surgical robotics
Instrumentation
Drug delivery systems
Diagnostics
Medical
equipment and
instrumentation
•
Medical imaging
Medical equipment
Website
In Vivo
In Vitro
Biotechnology
Company
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
AEPI - MedTech 2014
31
Grenoble-Isère, France:
A bright future in smart systems
ÂÂ The world’s 5th most inventive city
(Forbes, July 2013)
ÂÂ The highest concentration of research jobs
in France
ÂÂ A local ecosystem with a global reach: 4 out of 10
local manufacturing jobs are with foreign-owned
firms, and the US, Germany, and the UK are
leading the way in local business investment
The Grenoble-Isère Economic Development Agency (AEPI)
The Grenoble-Isère Economic Development Agency is tasked with
promoting investment and economic development.
The agency strives to promote the benefits of doing business in Grenoble-Isère nationally and internationally with the goal of attracting
new businesses to the area.
Your bridge between Grenoble-Isère and the world.
The agency focuses its efforts on the rest of Europe and the United States, and also runs a number of programs targeting Asia with
the support of the Invest in France Agency.
Over the past fifteen years, the agency has helped 440 businesses—both French- and foreign-owned—
move to Grenoble-Isère, contributing to the creation of 9,800 jobs.
The agency’s added value lies in its capacity to create the necessary conditions for effectively identifying and attracting
manufacturing businesses that could benefit from a foothold in Grenoble-Isère, and then giving them the support they
need to move here—and stay here for the long term. The area’s cross-cutting ecosystem encompassing higher education,
research, and industry provides particularly fertile ground for starting a new business or growing an existing one. The
agency leverages local economic development expertise with a vast, deep network of relevant contacts to give both
businesses and local governments the keys to successful development.
The Grenoble-Isère Economic Development Agency (AEPI)
1, place Firmin Gautier – 38027 Grenoble Cedex 1 – France
Tél : 04 76 70 97 18 – Fax : 04 76 70 97 19 – Email : [email protected]
AEPI - November 2014.
Photo credits : Pierre Jayet - Inria – H. Raguet – P. Stropa – Studio Pons – P. Avavian – A. Aubert – BioMérieux – CHU – Eccami – Fotolia – Shutterstock – Evéon – BD - Inria - JF Bachas - Inria - G. Cottet - - Trixell – D. Michon – Roche – Fotolia – Studio de Winter – Technosens – Tasda – IAB – H. Martin – M. Buscail