Insights

Insights
2326
The dream of Staphylococcal vaccination
Patrick M. Schlievert
2326
A Mad(2) modification modulating megakaryopoiesis
Adam Goldfarb
2327
Immunotherapy and the belly of the beast
Taha Merghoub and Jedd D. Wolchok
2328
THE
JOURNAL OF
EXPERIMENTAL
MEDICINE
FLUshing in the bathroom
VOLUME 211 NUMBER 12
NOVEMBER 17, 2014
www.jem.org
Carolina Amezcua, Nicola Gagliani, and Richard Flavell
2329
Too much of a good thing: NLRC4 and autoinflammation
Mark S. Anderson
Brief Definitive Reports
2331
Staphylococcus aureus infection induces protein A–mediated
immune evasion in humans
Noel T. Pauli, Hwan Keun Kim, Fabiana Falugi, Min Huang, John Dulac,
Carole Henry Dunand, Nai-Ying Zheng, Kaval Kaur, Sarah F. Andrews,
Yunping Huang, Andrea DeDent, Karen M. Frank, Angella Charnot-Katsikas,
Olaf Schneewind, and Patrick C. Wilson
2341
Sex steroid blockade enhances thymopoiesis by modulating
Notch signaling
Enrico Velardi, Jennifer J. Tsai, Amanda M. Holland, Tobias Wertheimer,
Vionnie W.C. Yu, Johannes L. Zakrzewski, Andrea Z. Tuckett, Natalie V. Singer,
Mallory L. West, Odette M. Smith, Lauren F. Young, Fabiana M. Kreines, Emily R. Levy,
Richard L. Boyd, David T. Scadden, Jarrod A. Dudakov, and Marcel R.M. van den Brink
2351
GPR18 is required for a normal CD8αα intestinal
intraepithelial lymphocyte compartment
Xiaoming Wang, Hayakazu Sumida, and Jason G. Cyster
2361
Enhanced HIV-1 immunotherapy by commonly arising
antibodies that target virus escape variants
Florian Klein, Lilian Nogueira, Yoshiaki Nishimura, Ganesh Phad, Anthony P. West Jr.,
Ariel Halper-Stromberg, Joshua A. Horwitz, Anna Gazumyan, Cassie Liu,
Thomas R. Eisenreich, Clara Lehmann, Gerd Fätkenheuer, Constance Williams,
Masashi Shingai, Malcolm A. Martin, Pamela J. Bjorkman, Michael S. Seaman,
Susan Zolla-Pazner, Gunilla B. Karlsson Hedestam, and Michel C. Nussenzweig
Articles
2373
Adiposity induces lethal cytokine storm after systemic
administration of stimulatory immunotherapy regimens in
aged mice
Annie Mirsoian, Myriam N. Bouchlaka, Gail D. Sckisel, Mingyi Chen,
Chien-Chun Steven Pai, Emanuel Maverakis, Richard G. Spencer,
Kenneth W. Fishbein, Sana Siddiqui, Arta M. Monjazeb, Bronwen Martin,
Stuart Maudsley, Charles Hesdorffer, Luigi Ferrucci, Dan L. Longo,
Bruce R. Blazar, Robert H. Wiltrout, Dennis D. Taub, and William J. Murphy
ON THE COVER
Mirsoian et al. demonstrate that
systemic administration of immunotherapy in mice with increased body
fat causes a lethal inflammatory
response. Image depicts a backdrop
of adipose tissue (pink) with immune
cells secreting cytokines (blue).
Artwork by Emilie Clark (Emilie@
emilieclark.com).
See page 2373
2385
An inherited mutation in NLRC4 causes autoinflammation
in human and mice
Akiko Kitamura, Yuki Sasaki, Takaya Abe, Hirotsugu Kano, and Koji Yasutomo
2397
Respiratory influenza virus infection induces
intestinal immune injury via microbiota-mediated
Th17 cell–dependent inflammation
Jian Wang, Fengqi Li, Haiming Wei, Zhe-Xiong Lian, Rui Sun, and Zhigang Tian
2411
Identification of Cdca7 as a novel Notch transcriptional target
involved in hematopoietic stem cell emergence
Jordi Guiu, Dylan J.M. Bergen, Emma De Pater, Abul B.M.M.K. Islam,
Verónica Ayllón, Leonor Gama-Norton, Cristina Ruiz-Herguido, Jessica González,
Nuria López-Bigas, Pablo Menendez, Elaine Dzierzak, Lluis Espinosa,
and Anna Bigas
2425
Sex steroid blockade enhances
thymopoiesis by modulating
Notch signaling
See page 2341
Limitation of immune tolerance–inducing
thymic epithelial cell development by Spi-B–mediated
negative feedback regulation
Nobuko Akiyama, Miho Shinzawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi,
Yusuke Shimo, Daisuke Ohshima, Koichi Matsuo, Izumi Sasaki, Katsuaki Hoshino,
Guoying Wu, Shintaro Yagi, Jun-ichiro Inoue, Tsuneyasu Kaisho,
and Taishin Akiyama
2439
Cytosolic carboxypeptidase CCP6 is required
for megakaryopoiesis by modulating Mad2 polyglutamylation
Buqing Ye, Chong Li, Zhao Yang, Yanying Wang, Junfeng Hao, Li Wang, Yi Li,
Ying Du, Lu Hao, Benyu Liu, Shuo Wang, Pengyan Xia, Guanling Huang, Lei Sun,
Yong Tian, and Zusen Fan
2455
Antigen-specific expansion and differentiation of natural killer
cells by alloantigen stimulation
Tsukasa Nabekura and Lewis L. Lanier
2467
Hrd1-mediated BLIMP-1 ubiquitination promotes
dendritic cell MHCII expression for CD4 T cell priming
during inflammation
Heeyoung Yang, Quan Qiu, Beixue Gao, Sinyi Kong, Zhenghong Lin, and Deyu Fang
GPR18 is required for a normal
CD8αα intestinal intraepithelial
lymphocyte compartment
See page 2351