Table of Contents

December 23, 2014 u vol. 111 u no. 51 u 18091–18400
Cover image: Pictured is a false-color scanning electron microscope image of framboidal pyrite
crystals (red) embedded in an organic-rich Cretaceous shale. The image is part of a nearly 70
gigapixel image mosaic covering around 1 cm2 that was acquired at a resolution of 40 nm per pixel.
Framboidal, or raspberry-like, pyrite is thought to reflect the activity of sulfate-reducing microbes.
Boswell A. Wing and Itay Halevy modeled how respiration by sulfate-reducing bacteria and
archaea discriminates, or fractionates, among sulfur isotopes. The results suggest that fractionation
may be influenced by each step of the microbial respiration pathway and by the levels of intracellular respiratory metabolites, leading to strain-specific sulfur isotope phenotypes. See the Feature
Article by Wing and Halevy on pages 18116–18125. Image courtesy of Fibics Incorporated.
From the Cover
18116 Microbial sulfur isotope biosignatures
18126 Surface signals and stem cell differentiation
18189 Gregariousness of chimpanzee mothers
18201 Structure of cytoprotective short RNAs
18279 3D dinosaur track ontogeny
Contents
E5490
Multifunctionality does not imply that all functions
are positively correlated
Jarrett Byrnes, Jonathan S. Lefcheck, Lars Gamfeldt,
John N. Griffin, Forest Isbell, and Andy Hector
E5491
Reply to Byrnes et al.: Aggregation can obscure
understanding of ecosystem multifunctionality
Mark A. Bradford, Stephen A. Wood, Richard D.
Bardgett, Helaina I. J. Black, Michael Bonkowski,
Till Eggers, Susan J. Grayston, Ellen Kandeler,
Peter Manning, Heikki Setälä, and T. Hefin Jones
THIS WEEK IN PNAS
18091
In This Issue
PNAS 100TH ANNIVERSARY ARTICLE
COMMENTARY
18093
OPINION—Leading scientists discuss current issues
18095
The split-brain: Rooting consciousness in biology
Michael S. Gazzaniga
See companion article on page 1765 in issue 10 of
volume 48
See Inner Workings on page 18097
LETTERS (ONLINE ONLY)
E5488
E5489
The smarter, the cleaner? Collaborative footprint:
A further look at taxi sharing
Luis Antonio López, Tiago Domingos, María Ángeles
Cadarso, and Jorge Enrique Zafrilla
Reply to Lopez et al.: Sustainable implementation of
taxi sharing requires understanding systemic effects
Paolo Santi, Giovanni Resta, Michael Szell, Stanislav
Sobolevsky, Steven H. Strogatz, and Carlo Ratti
INNER WORKINGS—An over-the-shoulder look at scientists at work
18097
Inner Workings: Discovering the split mind
Helen H. Shen
See Commentary on page 18093
RETROSPECTIVE
18098
Free online through the PNAS open access option.
Opinion: Mathematical models: A key tool for
outbreak response
Eric T. Lofgren, M. Elizabeth Halloran, Caitlin M. Rivers,
John M. Drake, Travis C. Porco, Bryan Lewis, Wan Yang,
Alessandro Vespignani, Jeffrey Shaman, Joseph N. S.
Eisenberg, Marisa C. Eisenberg, Madhav Marathe,
Samuel V. Scarpino, Kathleen A. Alexander, Rafael
Meza, Matthew J. Ferrari, James M. Hyman,
Lauren A. Meyers, and Stephen Eubank
Robert Letsinger: The father of synthetic
DNA chemistry
Marvin H. Caruthers
PNAS u December 23, 2014 u vol. 111 u no. 51 u iii–vii
COMMENTARIES
18100
Targeting osteosarcoma
Darien E. Reed and Kevan M. Shokat
See companion article on page E5564
18102
Predictive isotope model connects microbes in
culture and nature
Shuhei Ono, Min Sub Sim, and Tanja Bosak
See companion article on page 18116
18104
Simple insoluble cues specify stem cell differentiation
P. C. Dave P. Dingal, Rebecca G. Wells,
and Dennis E. Discher
See companion article on page 18126
18106
Mothers know best
Joan B. Silk
See companion article on page 18189
18108
tRNA-derived G-quadruplex protects motor neurons
Xiang-Lei Yang
See companion article on page 18201
18132
Site-specific vibrational spectral signatures of
water molecules in the magic H3O+(H2O)20 and
Cs+(H2O)20 clusters
Joseph A. Fournier, Conrad T. Wolke, Christopher J.
Johnson, Mark A. Johnson, Nadja Heine, Sandy
Gewinner, Wieland Schöllkopf, Tim K. Esser, Matias R.
Fagiani, Harald Knorke, and Knut R. Asmis
18138
Pictet–Spengler reaction-based biosynthetic machinery
in fungi
Wei Yan, Hui Ming Ge, Gang Wang, Nan Jiang,
Ya Ning Mei, Rong Jiang, Sui Jun Li, Chao Jun Chen,
Rui Hua Jiao, Qiang Xu, Seik Weng Ng,
and Ren Xiang Tan
18255
Real-time monitoring of quorum sensing in
3D-printed bacterial aggregates using scanning
electrochemical microscopy
Jodi L. Connell, Jiyeon Kim, Jason B. Shear, Allen J.
Bard, and Marvin Whiteley
COMPUTER SCIENCES
18144
PNAS PLUS
18110
Significance Statements
Brief statements written by the authors about the significance of
their papers.
INAUGURAL ARTICLE
18112
Scalable detection of statistically significant
communities and hierarchies, using message
passing for modularity
Pan Zhang and Cristopher Moore
EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES
18116
Intracellular metabolite levels shape sulfur
isotope fractionation during microbial
sulfate respiration
Boswell A. Wing and Itay Halevy
See Commentary on page 18102
18150
A complete Holocene record of trematode–bivalve
infection and implications for the response of
parasitism to climate change
John Warren Huntley, Franz T. Fürsich, Matthias Alberti,
Manja Hethke, and Chunlian Liu
18156
Impact of Antarctic mixed-phase clouds on climate
R. Paul Lawson and Andrew Gettelman
The second demographic transition: A concise
overview of its development
Ron Lesthaeghe
FEATURE ARTICLE
ENGINEERING
18116
Intracellular metabolite levels shape sulfur
isotope fractionation during microbial
sulfate respiration
Boswell A. Wing and Itay Halevy
See Commentary on page 18102
18162
Wireless gas detection with a smartphone via
rf communication
Joseph M. Azzarelli, Katherine A. Mirica, Jens B.
Ravnsbæk, and Timothy M. Swager
18167
Robust scaling of strength and elastic constants and
universal cooperativity in disordered
colloidal micropillars
Daniel J. Strickland, Yun-Ru Huang, Daeyeon Lee,
and Daniel S. Gianola
PHYSICAL SCIENCES
CHEMISTRY
E5492
18126
In vivo selective cancer-tracking gadolinium
eradicator as new-generation photodynamic
therapy agent
Tao Zhang, Rongfeng Lan, Chi-Fai Chan, Ga-Lai Law,
Wai-Kwok Wong, and Ka-Leung Wong
Signals from the surface modulate differentiation
of human pluripotent stem cells through
glycosaminoglycans and integrins
Paul J. Wrighton, Joseph R. Klim, Brandon A. Hernandez,
Chad H. Koonce, Timothy J. Kamp, and Laura L. Kiessling
See Commentary on page 18104
iv u www.pnas.org
ENVIRONMENTAL SCIENCES
18173
Direct measurements of methane emissions from
abandoned oil and gas wells in Pennsylvania
Mary Kang, Cynthia M. Kanno, Matthew C. Reid,
Xin Zhang, Denise L. Mauzerall, Michael A. Celia,
Yuheng Chen, and Tullis C. Onstott
PHYSICS
18178
Emergence of superconductivity in
heavy-electron materials
Yi-feng Yang (杨义峰) and David Pines
BIOCHEMISTRY
SOCIAL SCIENCES
E5498
Structural basis and dynamics of multidrug recognition
in a minimal bacterial multidrug resistance system
Judith Habazettl, Martin Allan, Pernille Rose Jensen,
Hans-Jürgen Sass, Charles J. Thompson,
and Stephan Grzesiek
E5508
Analogs of natural aminoacyl-tRNA synthetase
inhibitors clear malaria in vivo
Eva Maria Novoa, Noelia Camacho, Anna Tor, Barrie
Wilkinson, Steven Moss, Patricia Marín-García, Isabel G.
Azcárate, José M. Bautista, Adam C. Mirando,
Christopher S. Francklyn, Sònia Varon, Miriam Royo,
Alfred Cortés, and Lluís Ribas de Pouplana
E5518
Structural and functional studies of Bud23–Trm112
reveal 18S rRNA N7-G1575 methylation occurs on
late 40S precursor ribosomes
Juliette Létoquart, Emmeline Huvelle, Ludivine Wacheul,
Gabrielle Bourgeois, Christiane Zorbas, Marc Graille,
Valérie Heurgué-Hamard, and Denis L. J. Lafontaine
E5527
The N- and C-terminal autolytic fragments of
CAPN3/p94/calpain-3 restore proteolytic activity
by intermolecular complementation
Yasuko Ono, Mayumi Shindo, Naoko Doi, Fujiko
Kitamura, Carol C. Gregorio, and Hiroyuki Sorimachi
18213
Preassociated apocalmodulin mediates Ca2+-dependent
sensitization of activation and inactivation of
TMEM16A/16B Ca2+-gated Cl− channels
Tingting Yang, Wayne A. Hendrickson,
and Henry M. Colecraft
18219
Overexpression of Q-rich prion-like proteins suppresses
polyQ cytotoxicity and alters the polyQ interactome
Leslie Ripaud, Victoria Chumakova, Matthias Antonin,
Alex R. Hastie, Stefan Pinkert, Roman Körner, Kiersten M.
Ruff, Rohit V. Pappu, Daniel Hornburg, Matthias Mann,
F. Ulrich Hartl, and Mark S. Hipp
18225
Toward resolving the catalytic mechanism of
dihydrofolate reductase using neutron and
ultrahigh-resolution X-ray crystallography
Qun Wan, Brad C. Bennett, Mark A. Wilson, Andrey
Kovalevsky, Paul Langan, Elizabeth E. Howell,
and Chris Dealwis
18231
Escherichia coli dihydrofolate reductase catalyzed
proton and hydride transfers: Temporal order
and the roles of Asp27 and Tyr100
C. Tony Liu, Kevin Francis, Joshua P. Layfield, Xinyi
Huang, Sharon Hammes-Schiffer, Amnon Kohen,
and Stephen J. Benkovic
18237
Microbial biosynthesis of medium-chain 1-alkenes by
a nonheme iron oxidase
Zhe Rui, Xin Li, Xuejun Zhu, Joyce Liu, Bonnie Domigan,
Ian Barr, Jamie H. D. Cate, and Wenjun Zhang
PSYCHOLOGICAL AND COGNITIVE SCIENCES
18183
Cerebral coherence between communicators marks
the emergence of meaning
Arjen Stolk, Matthijs L. Noordzij, Lennart Verhagen,
Inge Volman, Jan-Mathijs Schoffelen, Robert Oostenveld,
Peter Hagoort, and Ivan Toni
SOCIAL SCIENCES
18112
18144
The second demographic transition: A concise
overview of its development
Ron Lesthaeghe
Scalable detection of statistically significant
communities and hierarchies, using message
passing for modularity
Pan Zhang and Cristopher Moore
SUSTAINABILITY SCIENCE
E5545
Fire responses to postglacial climate change and
human impact in northern Patagonia (41–43°S)
Virginia Iglesias and Cathy Whitlock
BIOLOGICAL SCIENCES
ANTHROPOLOGY
18189
18195
Early social exposure in wild chimpanzees: Mothers
with sons are more gregarious than mothers
with daughters
Carson M. Murray, Elizabeth V. Lonsdorf, Margaret A.
Stanton, Kaitlin R. Wellens, Jordan A. Miller, Jane
Goodall, and Anne E. Pusey
See Commentary on page 18106
Responses to social and environmental stress are
attenuated by strong male bonds in wild macaques
Christopher Young, Bonaventura Majolo, Michael
Heistermann, Oliver Schülke, and Julia Ostner
APPLIED BIOLOGICAL SCIENCES
18126
18201
18207
Signals from the surface modulate differentiation
of human pluripotent stem cells through
glycosaminoglycans and integrins
Paul J. Wrighton, Joseph R. Klim, Brandon A. Hernandez,
Chad H. Koonce, Timothy J. Kamp, and Laura L. Kiessling
See Commentary on page 18104
G-quadruplex structures contribute to the
neuroprotective effects of angiogenin-induced
tRNA fragments
Pavel Ivanov, Elizabeth O’Day, Mohamed M. Emara,
Gerhard Wagner, Judy Lieberman, and Paul Anderson
See Commentary on page 18108
Single-chain protein mimetics of the N-terminal
heptad-repeat region of gp41 with potential as
anti–HIV-1 drugs
Sara Crespillo, Ana Cámara-Artigas, Salvador Casares,
Bertrand Morel, Eva S. Cobos, Pedro L. Mateo,
Nicolas Mouz, Christophe E. Martin, Marie G. Roger,
Raphaelle El Habib, Bin Su, Christiane Moog,
and Francisco Conejero-Lara
BIOPHYSICS AND COMPUTATIONAL BIOLOGY
18243
Folding kinetics of WW domains with the united residue
force field for bridging microscopic motions and
experimental measurements
Rui Zhou, Gia G. Maisuradze, David Suñol, Toni Todorovski,
Maria J. Macias, Yi Xiao, Harold A. Scheraga, Cezary
Czaplewski, and Adam Liwo
18249
Automated analysis of immunohistochemistry images
identifies candidate location biomarkers for cancers
Aparna Kumar, Arvind Rao, Santosh Bhavani,
Justin Y. Newberg, and Robert F. Murphy
PNAS u December 23, 2014 u vol. 111 u no. 51 u v
CELL BIOLOGY
E5537
Bnip3 mediates doxorubicin-induced cardiac myocyte
necrosis and mortality through changes in
mitochondrial signaling
Rimpy Dhingra, Victoria Margulets, Subir Roy Chowdhury,
James Thliveris, Davinder Jassal, Paul Fernyhough,
Gerald W. Dorn II, and Lorrie A. Kirshenbaum
18255
Real-time monitoring of quorum sensing in
3D-printed bacterial aggregates using scanning
electrochemical microscopy
Jodi L. Connell, Jiyeon Kim, Jason B. Shear, Allen J.
Bard, and Marvin Whiteley
18261
18267
GATA2 facilitates steroid receptor coactivator
recruitment to the androgen receptor complex
Bin He, Rainer B. Lanz, Warren Fiskus, Chuandong Geng,
Ping Yi, Sean M. Hartig, Kimal Rajapakshe, John Shou,
Liping Wei, Shrijal S. Shah, Christopher Foley, Sue Anne
Chew, Vijay K. Eedunuri, Diego J. Bedoya, Qin Feng, Takashi
Minami, Constantine S. Mitsiades, Anna Frolov, Nancy L.
Weigel, Susan G. Hilsenbeck, Daniel G. Rosen, Timothy
Palzkill, Michael M. Ittmann, Yongcheng Song, Cristian
Coarfa, Bert W. O’Malley, and Nicholas Mitsiades
IMMUNOLOGY AND INFLAMMATION
E5555
Mechanisms of NDV-3 vaccine efficacy in MRSA
skin versus invasive infection
Michael R. Yeaman, Scott G. Filler, Siyang Chaili,
Kevin Barr, Huiyuan Wang, Deborah Kupferwasser,
John P. Hennessey Jr., Yue Fu, Clint S. Schmidt,
John E. Edwards Jr., Yan Q. Xiong,
and Ashraf S. Ibrahim
18291
Fibroblasts secrete Slit2 to inhibit fibrocyte
differentiation and fibrosis
Darrell Pilling, Zhichao Zheng, Varsha Vakil,
and Richard H. Gomer
MEDICAL SCIENCES
E5564
Complementary genomic approaches highlight the
PI3K/mTOR pathway as a common vulnerability
in osteosarcoma
Jennifer A. Perry, Adam Kiezun, Peter Tonzi, Eliezer M.
Van Allen, Scott L. Carter, Sylvan C. Baca, Glenn S.
Cowley, Ami S. Bhatt, Esther Rheinbay, Chandra Sekhar
Pedamallu, Elena Helman, Amaro Taylor-Weiner,
Aaron McKenna, David S. DeLuca, Michael S.
Lawrence, Lauren Ambrogio, Carrie Sougnez, Andrey
Sivachenko, Loren D. Walensky, Nikhil Wagle, Jaume
Mora, Carmen de Torres, Cinzia Lavarino, Simone
Dos Santos Aguiar, Jose Andres Yunes, Silvia Regina
Brandalise, Gabriela Elisa Mercado-Celis, Jorge
Melendez-Zajgla, Rocío Cárdenas-Cardós, Liliana
Velasco-Hidalgo, Charles W. M. Roberts, Levi A.
Garraway, Carlos Rodriguez-Galindo, Stacey B.
Gabriel, Eric S. Lander, Todd R. Golub, Stuart H.
Orkin, Gad Getz, and Katherine A. Janeway
See Commentary on page 18100
18297
HSP90 empowers evolution of resistance to
hormonal therapy in human breast cancer models
Luke Whitesell, Sandro Santagata, Marc L.
Mendillo, Nancy U. Lin, David A. Proia,
and Susan Lindquist
18303
Antagonist of GH-releasing hormone receptors
alleviates experimental ocular inflammation
Yong Jie Qin, Sun On Chan, Kelvin Kam Lung
Chong, Benjamin Fuk Loi Li, Tsz Kin Ng,
Yolanda Wong Ying Yip, Haoyu Chen, Mingzhi
Zhang, Norman L. Block, Herman S. Cheung,
Andrew V. Schally, and Chi Pui Pang
18309
ELAVL1 regulates alternative splicing of eIF4E
transporter to promote postnatal angiogenesis
Sung-Hee Chang, Olivier Elemento, Jiasheng
Zhang, Zhen W. Zhuang, Michael Simons,
and Timothy Hla
18315
Impact of an immune modulator fingolimod on acute
ischemic stroke
Ying Fu, Ningnannan Zhang, Li Ren, Yaping Yan,
Na Sun, Yu-Jing Li, Wei Han, Rong Xue, Qiang Liu,
Junwei Hao, Chunshui Yu, and Fu-Dong Shi
Dual-specificity phosphatase 5 regulates nuclear ERK
activity and suppresses skin cancer by inhibiting mutant
Harvey-Ras (HRasQ61L)-driven SerpinB2 expression
Linda K. Rushworth, Andrew M. Kidger, Laurent Delavaine,
Graeme Stewart, Susanne van Schelven, Jane Davidson,
Christopher J. Bryant, Edward Caddye, Philip East,
Christopher J. Caunt, and Stephen M. Keyse
ECOLOGY
18150
18273
A complete Holocene record of trematode–bivalve
infection and implications for the response of
parasitism to climate change
John Warren Huntley, Franz T. Fürsich, Matthias Alberti,
Manja Hethke, and Chunlian Liu
Anaerobic methane oxidation coupled to denitrification
is the dominant methane sink in a deep lake
Joerg S. Deutzmann, Peter Stief, Josephin Brandes,
and Bernhard Schink
ENVIRONMENTAL SCIENCES
E5545
Fire responses to postglacial climate change and
human impact in northern Patagonia (41–43°S)
Virginia Iglesias and Cathy Whitlock
EVOLUTION
18279
The birth of a dinosaur footprint: Subsurface 3D motion
reconstruction and discrete element simulation reveal
track ontogeny
Peter L. Falkingham and Stephen M. Gatesy
GENETICS
18285
Mitochondrial serine protease HTRA2 p.G399S in a
kindred with essential tremor and Parkinson disease
Hilal Unal Gulsuner, Suleyman Gulsuner, Fatma Nazli
Mercan, Onur Emre Onat, Tom Walsh, Hashem Shahin,
Ming K. Lee, Okan Dogu, Tulay Kansu, Haluk Topaloglu,
Bulent Elibol, Cenk Akbostanci, Mary-Claire King,
Tayfun Ozcelik, and Ayse B. Tekinay
vi u www.pnas.org
MICROBIOLOGY
18116
Intracellular metabolite levels shape sulfur
isotope fractionation during microbial
sulfate respiration
Boswell A. Wing and Itay Halevy
See Commentary on page 18102
18321
18327
Microbiota organization is a distinct feature of proximal
colorectal cancers
Christine M. Dejea, Elizabeth C. Wick, Elizabeth M.
Hechenbleikner, James R. White, Jessica L. Mark Welch,
Blair J. Rossetti, Scott N. Peterson, Erik C. Snesrud, Gary G.
Borisy, Mark Lazarev, Ellen Stein, Jamuna Vadivelu, April C.
Roslani, Ausuma A. Malik, Jane W. Wanyiri, Khean L.
Goh, Iyadorai Thevambiga, Kai Fu, Fengyi Wan, Nicolas
Llosa, Franck Housseau, Katharine Romans, XinQun Wu,
Florencia M. McAllister, Shaoguang Wu, Bert Vogelstein,
Kenneth W. Kinzler, Drew M. Pardoll, and Cynthia L. Sears
Host-specific induction of Escherichia coli fitness genes
during human urinary tract infection
Sargurunathan Subashchandrabose, Tracy H. Hazen, Ariel R.
Brumbaugh, Stephanie D. Himpsl, Sara N. Smith, Robert D.
Ernst, David A. Rasko, and Harry L. T. Mobley
PHARMACOLOGY
18363
Inflammatory sensitization of nociceptors depends on
activation of NMDA receptors in DRG satellite cells
Luiz Fernando Ferrari, Celina Monteiro Lotufo, Dionéia
Araldi, Marcos A. Rodrigues, Larissa P. Macedo,
Sérgio H. Ferreira, and Carlos Amilcar Parada
18369
Disruption of the Na+ ion binding site as a mechanism for
positive allosteric modulation of the mu-opioid receptor
Kathryn E. Livingston and John R. Traynor
PHYSIOLOGY
18375
Hummingbirds control hovering flight by stabilizing
visual motion
Benjamin Goller and Douglas L. Altshuler
18381
Functional heterogeneity of the four voltage sensors of
a human L-type calcium channel
Antonios Pantazis, Nicoletta Savalli, Daniel Sigg, Alan Neely,
and Riccardo Olcese
18387
Optogenetic activation of GnRH neurons reveals minimal
requirements for pulsatile luteinizing hormone secretion
Pauline Campos and Allan E. Herbison
NEUROSCIENCE
E5574
E5584
Restoration of visual function by expression of
a light-gated mammalian ion channel in retinal
ganglion cells or ON-bipolar cells
Benjamin M. Gaub, Michael H. Berry, Amy E. Holt,
Andreas Reiner, Michael A. Kienzler, Natalia Dolgova,
Sergei Nikonov, Gustavo D. Aguirre, William A. Beltran,
John G. Flannery, and Ehud Y. Isacoff
PLANT BIOLOGY
18393
Hebbian and neuromodulatory mechanisms interact
to trigger associative memory formation
Joshua P. Johansen, Lorenzo Diaz-Mataix, Hiroki
Hamanaka, Takaaki Ozawa, Edgar Ycu, Jenny Koivumaa,
Ashwani Kumar, Mian Hou, Karl Deisseroth, Edward S.
Boyden, and Joseph E. LeDoux
18183
Cerebral coherence between communicators marks
the emergence of meaning
Arjen Stolk, Matthijs L. Noordzij, Lennart Verhagen,
Inge Volman, Jan-Mathijs Schoffelen, Robert Oostenveld,
Peter Hagoort, and Ivan Toni
18333
Endogenous cannabinoid release within
prefrontal-limbic pathways affects memory
consolidation of emotional training
Maria Morena, Benno Roozendaal, Viviana Trezza,
Patrizia Ratano, Andrea Peloso, Daniela Hauer, Piray
Atsak, Luigia Trabace, Vincenzo Cuomo, James L.
McGaugh, Gustav Schelling, and Patrizia Campolongo
18339
Cortical plasticity induced by transplantation of
embryonic somatostatin or parvalbumin interneurons
Yunshuo Tang, Michael P. Stryker, Arturo Alvarez-Buylla,
and Juan Sebastian Espinosa
18345
αCGRP is essential for algesic exocytotic mobilization of
TRPV1 channels in peptidergic nociceptors
Isabel Devesa, Clotilde Ferrándiz-Huertas, Sakthikumar
Mathivanan, Christoph Wolf, Rafael Luján, Jean-Pierre
Changeux, and Antonio Ferrer-Montiel
18351
Context-dependent incremental timing cells in the
primate hippocampus
John J. Sakon, Yuji Naya, Sylvia Wirth, and Wendy A. Suzuki
18357
Dopamine-associated cached values are not sufficient
as the basis for action selection
Nick G. Hollon, Monica M. Arnold, Jerylin O. Gan,
Mark E. Walton, and Paul E. M. Phillips
Nucleoporin MOS7/Nup88 is required for mitosis in
gametogenesis and seed development in Arabidopsis
Guen Tae Park, Jennifer M. Frost, Jin-Sup Park, Tae Ho Kim,
Jong Seob Lee, Sung Aeong Oh, David Twell, Janie Sue
Brooks, Robert L. Fischer, and Yeonhee Choi
SYSTEMS BIOLOGY
E5593
rMATS: Robust and flexible detection of differential
alternative splicing from replicate RNA-Seq data
Shihao Shen, Juw Won Park, Zhi-xiang Lu, Lan Lin,
Michael D. Henry, Ying Nian Wu, Qing Zhou, and Yi Xing
CORRECTIONS
AGRICULTURAL SCIENCES
18399
Days to heading 7, a major quantitative locus determining
photoperiod sensitivity and regional adaptation in rice
He Gao, Mingna Jin, Xiao-Ming Zheng, Jun Chen, Dingyang
Yuan, Yeyun Xin, Maoqing Wang, Dongyi Huang, Zhe
Zhang, Kunneng Zhou, Peike Sheng, Jin Ma, Weiwei Ma,
Huafeng Deng, Ling Jiang, Shijia Liu, Haiyang Wang,
Chuanyin Wu, Longping Yuan, and Jianmin Wan
ECOLOGY, ENVIRONMENTAL SCIENCES
18400
Bioclimatic and physical characterization of the
world’s islands
Patrick Weigelt, Walter Jetz, and Holger Kreft
NEUROSCIENCE
18400
ix
Uridine adenosine tetraphosphate is a novel neurogenic
P2Y1 receptor activator in the gut
Leonie Durnin, Sung Jin Hwang, Masaaki Kurahashi,
Bernard T. Drumm, Sean M. Ward, Kent C. Sasse, Kenton M.
Sanders, and Violeta N. Mutafova-Yambolieva
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PNAS u December 23, 2014 u vol. 111 u no. 51 u vii