TOC - Circulation

Circulation
Volume 131 ◼ Number 3
January 20, 2015
Clinical Summaries. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
Editorials
Is It All Determined at Menarche?
Renate B. Schnabel, MD, MSc . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
Preventing Cardiovascular Disease: Going Beyond Conventional Risk Assessment
Samuel S. Gidding, MD; Erica Sood, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 230
Using “Big Data” to Dissect Clinical Heterogeneity
Russ B. Altman, MD, PhD; Euan A. Ashley, MRCP, DPhil . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 232
A New Phenotypic Lexicon for Accelerated Translation: Rise of the Machines
Calum A. MacRae, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 234
Original Articles
Epidemiology and Prevention
Age at Menarche and Risks of Coronary Heart and Other Vascular Diseases in a Large UK Cohort
Dexter Canoy, MD, PhD; Valerie Beral, FRS; Angela Balkwill, MSc; F. Lucy Wright, BN, DPhil;
Mary E. Kroll, DPhil; Gillian K. Reeves, PhD; Jane Green, MB, ChB, DPhil; Benjamin J. Cairns, PhD;
for the Million Women Study Collaborators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237
Cumulative Effect of Psychosocial Factors in Youth on Ideal Cardiovascular Health in Adulthood: The
Cardiovascular Risk in Young Finns Study
Laura Pulkki-Råback, PhD; Marko Elovainio, PhD; Christian Hakulinen, PhD; Jari Lipsanen, MA;
Mirka Hintsanen, PhD; Markus Jokela, PhD; Laura D. Kubzansky, PhD; Taina Hintsa, PhD; Anna Serlachius, PhD;
Tomi Laitinen, MD; Katja Pahkala, PhD; Vera Mikkilä, PhD; Jaakko Nevalainen, PhD; Nina Hutri-Kähönen, MD;
Markus Juonala, MD; Jorma Viikari, MD, PhD; Olli T. Raitakari, MD; Liisa Keltikangas-Järvinen, PhD . . . . . . . . . . 245
Vitamin D Therapy in Individuals With Prehypertension or Hypertension: The DAYLIGHT Trial
Pankaj Arora, MD; Yanna Song, MS; Jeffery Dusek, PhD; Gregory Plotnikoff, MD; Marc S. Sabatine, MD;
Susan Cheng, MD; Andre Valcour, PhD; Heather Swales, MD; Beth Taylor, PhD; Erin Carney, BS; Derek Guanaga, BS;
Joseph R. Young, BA; Courtney Karol, BS; Michael Torre, BS; Atum Azzahir, BA; Semerit M. Strachan, MD;
Dillon C. O’Neill, BA; Myles Wolf, MD, MMSc; Frank Harrell, PhD; Christopher Newton-Cheh, MD, MPH;
Thomas J. Wang, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 254
Familial Clustering of Mitral Valve Prolapse in the Community
Francesca N. Delling, MD; Jian Rong, PhD; Martin G. Larson, ScD; Birgitta Lehman, RDCS; Ewa Osypiuk, MD;
Plamen Stantchev, MD; Susan A. Slaugenhaupt, PhD; Emelia J. Benjamin, MD, ScM; Robert A. Levine, MD;
Ramachandran S. Vasan, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263
Heart Failure
Phenomapping for Novel Classification of Heart Failure With Preserved Ejection Fraction
Sanjiv J. Shah, MD; Daniel H. Katz, MD; Senthil Selvaraj, MD, MA; Michael A. Burke, MD; Clyde W. Yancy, MD, MSc;
Mihai Gheorghiade, MD; Robert O. Bonow, MD; Chiang-Ching Huang, PhD; Rahul C. Deo, MD, PhD CME . . . . . . 269
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Hypertension
Renal Dysfunction Is Associated With a Reduced Contribution of Nitric Oxide and Enhanced Vasoconstriction
After a Congenital Renal Mass Reduction in Sheep
Yugeesh R. Lankadeva, PhD; Reetu R. Singh, PhD; Karen M. Moritz, PhD; Helena C. Parkington, PhD;
Kate M. Denton, PhD; Marianne Tare, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 280
Stroke
Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation
Christopher C. Gibson, PhD; Weiquan Zhu, PhD; Chadwick T. Davis, PhD; Jay A. Bowman-Kirigin, BS;
Aubrey C. Chan, MD, PhD; Jing Ling, BA; Ashley E. Walker, PhD; Luca Goitre, PhD; Simona Delle Monache, PhD;
Saverio Francesco Retta, PhD; Yan-Ting E. Shiu, PhD; Allie H. Grossmann, MD, PhD; Kirk R. Thomas, PhD;
Anthony J. Donato, PhD; Lisa A. Lesniewski, PhD; Kevin J. Whitehead, MD; Dean Y. Li, MD, PhD . . . . . . . . . . . . . . . 289
Vascular Medicine
Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity
Nazish Sayed, MD, PhD; Wing Tak Wong, PhD; Frank Ospino, BS; Shu Meng, PhD; Jieun Lee, PhD; Arshi Jha, MS;
Phillip Dexheimer, MS; Bruce J. Aronow, PhD; John P. Cooke, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300
Contemporary Reviews in Cardiovascular Medicine
Aneurysms of the Pulmonary Artery
Maximilian Kreibich, MD; Matthias Siepe, MD; Johannes Kroll, MD; René Höhn, MD; Jochen Grohmann, MD;
Friedhelm Beyersdorf, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 310
Clinician Update
Fat Embolism Syndrome
Ethan Kosova, MD, MPH; Brian Bergmark, MD; Gregory Piazza; MD, MS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317
ECG Challenge
ECG Challenge: January 20, 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Images in Cardiovascular Medicine
Hypersensitivity Reaction in the US Food and Drug Administration–Approved Second-Generation DrugEluting Stents: Histopathological Assessment With Ex Vivo Optical Coherence Tomography
Fumiyuki Otsuka, MD, PhD; Kazuyuki Yahagi, MD; Elena Ladich, MD; Robert Kutys, MS; Russell Alexander, MD;
David Fowler, MD; Renu Virmani, MD; Michael Joner, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 322
Rare Case of Cardiac Hemangioma Causing Massive Pericardial Effusion: Can a Left Atrial Tumor Produce
Pericardial Effusion?
Soji Nishio, MD; Kunihiko Kosuga, MD, PhD, FJCC; Senri Miwa, MD, PhD; Yasue Fujiwara, MD;
Kazuhiko Katsuyama, MD, PhD; Tatsuhiko Hata, MD, PhD; Masaharu Okada, MD, PhD; Yuzo Takeuchi, MD, PhD;
Shinsaku Takeda, MD; Yasutaka Inuzuka, MD, PhD; Junya Seki, MD; Eiji Takeuchi, MD, PhD; Tsuyoshi Terashima, MD;
Shigeru Ikeguchi, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e21
Correspondence
Letter by Kumar Regarding Article, “Contribution of Intimal Smooth Muscle Cells to Cholesterol
Accumulation and Macrophage-Like Cells in Human Atherosclerosis"
Arun H.S. Kumar, DVM, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e24
Response to Letter Regarding Article, “Contribution of Intimal Smooth Muscle Cells to Cholesterol
Accumulation and Macrophage-Like Cells in Human Atherosclerosis”
Gordon A. Francis, MD; Sima Allahverdian, MD, PhD; Ali Cyrus Cheroudi; Thomas Abraham, PhD;
Bruce M. McManus, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e25