TOC - Circulation

Circulation
Volume 131 ◼ Number 4
January 27, 2015
Clinical Summaries. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325
Editorials
Pediatric Cardiac Surgery: The Long View
Marshall L. Jacobs, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 328
Declining Use Rates of Revascularization for Medicare Patients: Is This a Real Trend?
Timothy J. Gardner, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331
Harnessing the Nitrate–Nitrite–Nitric Oxide Pathway for Therapy of Heart Failure With Preserved Ejection
Fraction
Rebecca Vanderpool, PhD; Mark T. Gladwin, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 334
Original Articles
Congenital Heart Disease
Achievements in Congenital Heart Defect Surgery: A Prospective, 40-Year Study of 7038 Patients
Gunnar Erikssen, MD; Knut Liestøl, PhD; Egil Seem, MD; Sigurd Birkeland, MD; Kjell Johan Saatvedt, MD;
Tom Nilsen Hoel, MD; Gaute Døhlen, MD; Helge Skulstad, MD; Jan Ludvig Svennevig, MD; Erik Thaulow, MD;
Harald Lauritz Lindberg, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337
Progress in Late Results Among Pediatric Cardiac Surgery Patients: A Population-Based 6-Decade Study With
98% Follow-Up
Alireza Raissadati, MD; Heta Nieminen, MD, PhD; Eero Jokinen, MD, PhD; Heikki Sairanen, MD, PhD . . . . . . . . . . 347
Epidemiology and Prevention
Components of Hemodynamic Load and Cardiovascular Events: The Framingham Heart Study
Leroy L. Cooper, PhD; Jian Rong, PhD; Emelia J. Benjamin, MD, ScM; Martin G. Larson, ScD; Daniel Levy, MD;
Joseph A. Vita, MD; Naomi M. Hamburg, MD, MS; Ramachandran S. Vasan, MD; Gary F. Mitchell, MD . . . . . . . . . . 354
Health Services and Outcomes Research
Trends in Coronary Revascularization Procedures Among Medicare Beneficiaries Between 2008 and 2012
Steven D. Culler, PhD; Aaron D. Kugelmass, MD; Phillip P. Brown, MD; Matthew R. Reynolds, MD;
April W. Simon, RN, MSN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 362
Heart Failure
Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction
Payman Zamani, MD; Deepa Rawat, MD; Prithvi Shiva-Kumar, MD, MS; Salvatore Geraci, RDCS; Rushik Bhuva, MD;
Prasad Konda, MD; Paschalis-Thomas Doulias, PhD; Harry Ischiropoulos, PhD; Raymond R. Townsend, MD;
Kenneth B. Margulies, MD; Thomas P. Cappola, MD, ScM; David C. Poole, PhD, DSc; Julio A. Chirinos, MD, PhD . . . . . . 371
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Hypertension
Paradoxical Normoxia-Dependent Selective Actions of Inorganic Nitrite in Human Muscular Conduit Arteries
and Related Selective Actions on Central Blood Pressures
Sami A. Omar, MRCP, MBBS; Henry Fok, MRCP, MBBS; Katharina D. Tilgner, BSc, MSc; Ashok Nair, FRCA, MSc, MBBS;
Joanne Hunt, PhD; Benyu Jiang, PhD; Paul Taylor, PhD; Phil Chowienczyk, FRCP; Andrew J. Webb, FRCP, PhD . . . . . . 381
Molecular Cardiology
Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca2+/CalmodulinDependent Protein Kinase II Signaling
Malik Bisserier, MSc; Magali Berthouze-Duquesnes, PhD; Magali Breckler, PhD; Florence Tortosa, MSc;
Loubina Fazal, PhD; Annélie de Régibus, MSc; Anne-Coline Laurent, PharmD, PhD; Audrey Varin, MSc;
Alexandre Lucas, MSc; Maxime Branchereau, MSc; Pauline Marck, MSc; Jean-Nicolas Schickel, PhD;
Claudine Deloménie, PhD; Olivier Cazorla, PhD; Pauline Soulas-Sprauel, PhD; Bertrand Crozatier, MD, PhD;
Eric Morel, PhD; Christophe Heymes, PhD; Frank Lezoualc’h, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 390
Vascular Medicine
Peripheral Blood Signature of Vasodilator-Responsive Pulmonary Arterial Hypertension
Anna R. Hemnes, MD; Aaron W. Trammell, MD; Stephen L. Archer, MD; Stuart Rich, MD; Chang Yu, PhD;
Hui Nian, PhD; Niki Penner; Mitchell Funke, BA; Lisa Wheeler, BA; Ivan M. Robbins, MD; Eric D. Austin, MD, MSCI;
John H. Newman, MD; James West, PhD CME . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401
Controversies in Cardiovascular Medicine
Can Coronary Computed Tomography Angiography Replace Invasive Angiography? Yes: It is All About
Finding the Right Test for the Right Person at the Right Time
Stephan Achenbach, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 410
Can Coronary Computed Tomography Angiography Replace Invasive Angiography? Coronary Computed
Tomography Angiography Cannot Replace Invasive Angiography
Giulio G. Stefanini, MD; Stephan Windecker, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 418
ECG Challenge Response
ECG Response: January 27, 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 427
Images in Cardiovascular Medicine
Severe Right Atrial Compression by a Rapidly Growing Cardiac Mass
Angélica María Romero Daza, MD; M. A. Navas Lobato, MD; Teresa Reina Duran, MD;
Gonzalo Aldamiz Echevarría, MD; Angeles Heredero Jung, MD; Marta Tomas, MD; Miguel Orejas Orejas, MD;
Jerónimo Farré, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 429
Effect of Tumor Necrosis Factor Inhibitor Treatment on Proximal Right Coronary Chronic Total Occlusion in
a Patient With Rheumatoid Arthritis
Michael Behnes, MD; Ibrahim Akin, MD; Martin Borggrefe, MD; Dominik Traunwieser, MD; Hans Neuser, MD;
Kambis Mashayekhi, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e26
In Memoriam
Joseph A. Vita, MD, 1956–2014
John F. Keaney, Jr, MD; Joseph Loscalzo, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 432
AHA Statistical Update
Executive Summary: Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart
Association
Dariush Mozaffarian, MD, DrPH, FAHA; Emelia J. Benjamin, MD, ScM, FAHA; Alan S. Go, MD;
Donna K. Arnett, PhD, MSPH, FAHA; Michael J. Blaha, MD, MPH; Mary Cushman, MD, MSc, FAHA;
Sarah de Ferranti, MD, MPH; Jean-Pierre Després, PhD, FAHA; Heather J. Fullerton, MD, MAS;
Virginia J. Howard, PhD, FAHA; Mark D. Huffman, MD, MPH, FAHA; Suzanne E. Judd, PhD;
Brett M. Kissela, MD, MS, FAHA; Daniel T. Lackland, DrPH, MSPH, FAHA; Judith H. Lichtman, PhD, MPH;
Lynda D. Lisabeth, PhD, MPH, FAHA; Simin Liu, MD, ScD, FAHA; Rachel H. Mackey, PhD, MPH, FAHA;
David B. Matchar, MD, FAHA; Darren K. McGuire, MD, MHSc, FAHA; Emile R. Mohler III, MD, FAHA;
Claudia S. Moy, PhD, MPH; Paul Muntner, PhD; Michael E. Mussolino, PhD, FAHA; Khurram Nasir, MD, MPH;
Robert W. Neumar, MD, PhD; Graham Nichol, MD, MPH, FAHA; Latha Palaniappan, MD, MS, FAHA;
Dilip K. Pandey, MD, PhD, FAHA; Mathew J. Reeves, PhD, FAHA; Carlos J. Rodriguez, MD, MPH, FAHA;
Paul D. Sorlie, PhD; Joel Stein, MD; Amytis Towfighi, MD; Tanya N. Turan, MD, MSCR, FAHA; Salim S. Virani, MD, PhD;
Joshua Z. Willey, MD, MS; Daniel Woo, MD, MS, FAHA; Robert W. Yeh, MD, MSc, FAHA; Melanie B. Turner, MPH;
on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee . . . . . . . . . . . . . 434
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Dariush Mozaffarian, MD, DrPH, FAHA; Emelia J. Benjamin, MD, ScM, FAHA; Alan S. Go, MD;
Donna K. Arnett, PhD, MSPH, FAHA; Michael J. Blaha, MD, MPH; Mary Cushman, MD, MSc, FAHA;
Sarah de Ferranti, MD, MPH; Jean-Pierre Després, PhD, FAHA; Heather J. Fullerton, MD, MAS;
Virginia J. Howard, PhD, FAHA; Mark D. Huffman, MD, MPH, FAHA; Suzanne E. Judd, PhD;
Brett M. Kissela, MD, MS, FAHA; Daniel T. Lackland, DrPH, MSPH, FAHA; Judith H. Lichtman, PhD, MPH;
Lynda D. Lisabeth, PhD, MPH, FAHA; Simin Liu, MD, ScD, FAHA; Rachel H. Mackey, PhD, MPH, FAHA;
David B. Matchar, MD, FAHA; Darren K. McGuire, MD, MHSc, FAHA; Emile R. Mohler III, MD, FAHA;
Claudia S. Moy, PhD, MPH; Paul Muntner, PhD; Michael E. Mussolino, PhD, FAHA; Khurram Nasir, MD, MPH;
Robert W. Neumar, MD, PhD; Graham Nichol, MD, MPH, FAHA; Latha Palaniappan, MD, MS, FAHA;
Dilip K. Pandey, MD, PhD, FAHA; Mathew J. Reeves, PhD, FAHA; Carlos J. Rodriguez, MD, MPH, FAHA;
Paul D. Sorlie, PhD; Joel Stein, MD; Amytis Towfighi, MD; Tanya N. Turan, MD, MSCR, FAHA; Salim S. Virani, MD, PhD;
Joshua Z. Willey, MD, MS; Daniel Woo, MD, MS, FAHA; Robert W. Yeh, MD, MSc, FAHA; Melanie B. Turner, MPH;
on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee . . . . . . . . . . . . . e29
Correspondence
Letter by Yasue et al Regarding Article, “Clinical Usefulness, Angiographic Characteristics, and Safety
Evaluation of Intracoronary Acetylcholine Provocation Testing Among 921 Consecutive White Patients With
Unobstructed Coronary Arteries”
Hirofumi Yasue, MD, PhD; Yuji Mizuno, MD, PhD; Eisaku Harada, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e323
Letter by Mohri Regarding Article, “Clinical Usefulness, Angiographic Characteristics, and Safety Evaluation
of Intracoronary Acetylcholine Provocation Testing Among 921 Consecutive White Patients With Unobstructed
Coronary Arteries”
Masahiro Mohri, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e324
Response to Letters Regarding Article, “Clinical Usefulness, Angiographic Characteristics, and Safety
Evaluation of Intracoronary Acetylcholine Provocation Testing Among 921 Consecutive White Patients With
Unobstructed Coronary Arteries”
Peter Ong, MD; Anastasios Athanasiadis, MD; Gabor Borgulya, MD, MSc; Ismail Vokshi, MBBS;
Rachel Bastiaenen, MBBS; Sebastian Kubik; Stephan Hill, MD; Tim Schäufele, MD; Heiko Mahrholdt, MD;
Juan Carlos Kaski, MD, DSc; Udo Sechtem, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e325
Correction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e326