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BIOCHEMISTRY FOR THE HEALTH SCIENCES
BISC 2070 – Spring 2015
Course Director:
Office:
Lab:
Telephone:
E-mail:
Web Site:
Office Hours:
Kevin R. Siebenlist, Ph.D.
Walter Schroeder Complex, Room 320B
Walter Schroeder Complex, Room 308
86555 (288-6555)
[email protected]
http://academic.mu.edu/bisc/siebenlistk
Mon, Wed, and Fri 11:00 pm - 1:50 pm; by appointment; and by chance
Course Description:
This is a one-semester biochemistry course designed for the health professional. All cells and organisms require
three things to survive and propagate; precursors, energy, and information. The first part of the course examines the
structure and chemistry of the precursors; the carbohydrates, lipids, and amino acids. Using these precursors as a
starting point; proteins, enzymes, and membrane structure and function are discussed. In addition, the structure and
function of vitamins and the role they play as coenzymes or cosubstrates for enzymes is presented. The second
segment of the course deals with how the precursor molecules are used to generate or store energy. Their oxidation
to CO2 and H2O for energy and their use in the synthesis of complex biomolecules is explored. Emphasis is placed
upon the control mechanisms of metabolism and the interrelationships between the metabolism of the variety of
precursors. It is important to understand how metabolism functions as a unified whole. Lastly, the information
molecules, the molecular biology of the cell is investigated. In this section the structure and function of
Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) is discussed. Information storage in DNA, the flow of
information from DNA to RNA, and the utilization of this information to direct the synthesis of proteins are
described. Gene cloning and the molecular aspects of health and disease at the level of DNA are discussed in this
section. Throughout the course, special emphasis is placed upon how biochemistry relates to normal health and
disease.
Course Objectives:
Students will gain an understanding of:
1. the process of life at the molecular level.
2. how living matter is formed, maintained, and destroyed.
3. the process, control, and regulation of metabolism.
4. how the internal environment, diet, and hormones affect the living organism.
5. the flow of biological information from DNA through RNA to protein.
6. the biochemical basis of health and disease.
Course Learning Outcomes:
1. Students will have a working vocabulary (can give a definition, use terms in context, apply the term to a new
context) of biochemical terms.
2. Students will distinguish/identify/explain the biochemical structure of proteins, carbohydrates, and lipids.
3. Students will distinguish/explain the various functions of proteins, carbohydrates, and lipids.
4. Students will discriminate between the important metabolic pathways of the cell in health and disease.
5. Students will predict/explain the behavior of biomolecules/biochemical systems by applying chemical
principles to these systems.
6. Students will integrate the structures and functions of biomolecules with the metabolism and molecular
biology of the cell in health and disease.
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Resources:
Required Texts:
GENERAL, ORGANIC, AND BIOCHEMISTRY, 8th Ed., Katherine J. Denniston, Joseph J. Topping, Kim R.
Woodrum, & Robert L. Caret, McGraw Hill, 2014.
Attendance Policy:
Attendance is not required, but very strongly recommended. Although not required, attendance will be taken using
sign-in sheets. Data collected from the sign in sheets will be used to identify students whose excessive absences may
be affecting their performance.
My Web Site:
My academic web site is: http://academic.mu.edu/bisc/siebenlistk. I will post on this site copies of the figures used
during lecture, lecture notes, study guides, and any other information / data necessary for you to have.
Homework:
Homework assignments will be posted on the McGraw Hill Connect Web Site. To register on this site go to:
https://connect.mheducation.com/class/k-siebenlist-spring-2015
and click the “register now” button. Access to individual homework assignments will be opened while the topic is
being discussed or shortly after. Access will be closed at 12:00 noon on the day of the exam covering that topic. A
total of 12 homework assignments will be posted. A total of 10 homework assignments must be completed over the
course of the semester. Greater than 10 homework assignments may be completed in which case the final
homework grade will be computed employing the best 10 homework assignments.
Evaluation Criteria/Methods:
Final grades are based upon 700 possible points. There will be four in course examinations worth 100 points each
(400 possible points total). In course exams will consist of 50+ multiple-choice questions. The homework
assignments will be worth a maximum of 100 points toward the final grade. Assigned problems are representative of
the types seen on the in course exams. There will be a cumulative final exam worth 200 points. The cutoffs for
assigning grades are given below.
Letter Grade
A
AB
B
BC
C
CD
D
F
Points (Cumulative)
644 - 700 (92%)
609 - 643 (87%)
560 - 608 (80%)
525 - 559 (75%)
469 - 524 (67%)
434 - 468 (62%)
378 - 433 (54%)
0 - 377
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Course Outline
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Date
01/12
01/14
01/16
01/19
01/21
01/23
01/26
01/28
01/30
02/02
02/04
02/06
02/09
02/11
02/13
02/16
02/18
02/20
02/23
02/25
02/27
03/02
22 03/04
23 03/06
03/09
03/11
03/13
24 03/16
25 03/18
26 03/20
27 03/23
28 03/25
29 03/27
30 03/30
31 04/01
04/03
04/06
Title
Introduction
Carbohydrates
Carbohydrates
Martin Luther King Day
Carbohydrates
Lipids and Their Functions in Biochemical Systems
Lipids and Their Functions in Biochemical Systems
Lipids and Their Functions in Biochemical Systems
Protein Structure and Function
Protein Structure and Function
EXAM 1
Protein Structure and Function
Enzymes
Enzymes
Enzymes
Biosignaling: Neurotransmitters & Hormones
Biosignaling: Neurotransmitters & Hormones
Biosignaling: Neurotransmitters & Hormones
Carbohydrate Metabolism (Glycolysis)
EXAM 2
Carbohydrate Metabolism (Glycolysis)
Aerobic Respiration & Energy Production (Citric Acid
Cycle)
Aerobic Respiration & Energy Production (Oxidative
Phosphorylation)
Carbohydrate Metabolism (Other Pathways)
Spring Break
Spring Break
Spring Break
Carbohydrate Metabolism (Other Pathways)
Carbohydrate Metabolism (Other Pathways)
Fatty Acid Metabolism
Fatty Acid Metabolism
EXAM 3
Fatty Acid Metabolism
Fatty Acid Metabolism
Metabolism of Amino Acids
Easter Break
Easter Break
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Readings
Chap Section
Pages
16
16
16.1 – 16.4
16.4 – 16.5
547 – 567
559 – 570
16
17
17
17
18
18
16.5 – 16.6
17.1 – 17.2
17.3 – 17.4
17.5 – 17.6
18.1 – 18.3
18.4 – 18.6
567 – 575
581 – 590
590 – 605
605 – 613
617 – 626
626 – 632
18
19
19
19
Web
Web
Web
21
18.7 – 18.10
19.1 – 19.6
19.8 – 19.12
19.7
Site
Site
Site
21.1 – 21.4
633 – 641
649 – 662
666 – 680
663 – 666
Notes
Notes
Notes
727 – 744
21
22
21.1 – 21.4
22.1 – 22.5
727 – 744
761 – 774
22
22.6
774 – 778
21
21.5 – 21.7
744 – 757
21
Web
23
23
21.5 – 21.7
Site
23.1 – 23.6
23.1 – 23.6
744 – 757
Notes
793 – 816
793 – 816
23
23
18
22
23.1 – 23.6
23.1 – 23.6
18.11
22.7 – 22.8
793 – 816
793 – 816
641 – 645
778 – 790
32 04/08
33 04/10
34 04/13
Metabolism of Amino Acids
Introduction to Molecular Genetics – Structure
Introduction to Molecular Genetics – DNA Replication
22
20
20
22.7 – 22.8
20.1 – 20.2
20.3 & 20.7
778 – 790
684 – 693
693 – 698
&
708 – 711
35
36
37
38
39
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41
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EXAM 4
Introduction to Molecular Genetics – Transcription
Introduction to Molecular Genetics – Transcription
Introduction to Molecular Genetics – Translation
Introduction to Molecular Genetics – Translation
Introduction to Molecular Genetics – Recombinant DNA
Introduction to Molecular Genetics – Recombinant DNA
Catch-Up / Review
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20
20
20
20
20
20.4
20.4
20.5 – 20.6
20.5 – 20.6
20.8 – 20.10
20.8 – 20.10
698 – 702
698 – 702
702 – 708
702 – 708
711 – 724
711 – 724
04/15
04/17
04/20
04/23
04/24
04/27
04/29
05/01
Cumulative Final Examination - 100 questions
Wednesday May 06, 2015 from 8:00 am to 10:00 am
^]^]^]^]^]^]^]^]^]^]^]^]^]^]^]^]^]^]^]^]^]
Tutoring – “FREE tutoring will be offered for most freshmen and sophomore-level courses beginning Monday,
January 26th in AMU 317. To sign up, students should come to AMU 317 and fill out a Tutor Request Form
anytime. Tutorial groups meet for one hour each week and are grouped by subject/instructor. Signing up is
voluntary, but attendance is taken. Tutorial groups will continue to open as needed through mid-April. It’s firstcome, first-served, so sign up sooner than later! Any questions call 414-288-3270 or stop in.”
(http://www.marquette.edu/oses/index.shtml).
Biochemistry is a difficult course for some students. Remember to use all of your resources for learning. Come to
the Discussions and ask to have topics that are unclear to you explained again. During discussion we have time to go
over any topic or topics at a slower pace and time to answer any and all questions in detail. Contact Dr. Siebenlist
after class or during office hours when you have a question or problem. He expects to see students that are having
difficulties. Use the Tutoring Sessions as an additional source for explanations, answers, and to reinforce you
learning. Dr. Siebenlist and the Tutoring Session Leaders are present to insure that you master the material. Take
advantage of your tuition dollars.
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