Champak Chatterjee, Ph.D. Assistant Professor of Chemistry

Champak Chatterjee, Ph.D. Assistant Professor of Chemistry

Champak Chatterjee, Ph.D.
Assistant Professor of Chemistry
University of Washington, Seattle 98195
[email protected]
EDUCATION
1999-2005
1997-1999
1993-1996
University of Illinois, Urbana-Champaign
Ph.D., Chemistry
Indian Institute of Technology, Bombay M.Sc. (1st in Class), Organic Chemistry
University of Bombay, India
B.Sc. (First Class), Chemistry
PROFESSIONAL EXPERIENCE
7/10-present Assistant Professor of Chemistry
8/05-6/10
Post-doctoral Research Associate
University of Washington, Seattle
The Rockefeller University, New York City
HONORS AND AWARDS
2015
2015
2014
2014
2014
2013
2013
2012
2001
1999-2001
1998
Invited speaker, Frontiers in Chromatin Biology and Chemical Epigenetics/Epigenomics
Invited speaker, Chemical Protein Synthesis Meeting, St. Augustine, Florida
Discussion Leader, Gordon Research Conference in Enzymes and Metabolic Pathways
Alumni Achievement Award, V.G. Vaze College, Mumbai, India
Young Investigator in Medicinal Chemistry, 247th ACS Natl. Meeting, Dallas, TX
M.J. Murdock Charitable Trust, Partners in Science Grant
Local Co-chair, 43rd ACS National Organic Symposium, Seattle, WA
Discussion Leader, Gordon Research Conference in Bioorganic Chemistry
Excellent teacher distinction, UIUC Center for Teaching Excellence
Fellowship in Chemical Biology, University of Illinois
Silver Medal for first in graduating class, IIT Bombay
PEER-REVIEWED RESEARCH PUBLICATIONS (* denotes as a P.I. at UW)
1.
Jastrab, J.B.; Wang, T.; Murphy, J.P.; Bai, L.; Hu, K.; Merkx, R.; Huang, J.; Chatterjee, C.
*; Ovaa, H.; Gygi, S.P.; Li, H.; Darwin, K.H. An adenosine triphosphate-independent
proteasome activator contributes to the virulence of Mycobacterium tuberculosis Proc.
Natl. Acad. Sci. U.S.A. 2015, 112, E1763-E1772.
2.
Dhall, A.; Wei, S.; Fierz, B.; Woodcock, C.; Lee, T.-H.; Chatterjee, C.* Sumoylated human
histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions J. Biol. Chem. 2014, 289, 33827-33837.
3.
Weller, C.E.; Huang, V.; Chatterjee, C.* Facile synthesis of native and protease-resistant
ubiquitylated peptides ChemBioChem 2014, 15, 1263-1267.
4.
Smirnov, D.; Dhall, A.; Sivanesam, K.; Sharar, R.J.; Chatterjee, C.* Fluorescent probes
reveal a minimal ligation recognition motif in the prokaryotic ubiquitin-like protein from
Mycobacterium tuberculosis. J. Am. Chem. Soc. 2013, 135, 2887-2890.
5.
Meier, F.; Abeywardana, T.; Dhall, A.; Marotta, N. P.; Varkey, J.; Langen, R.; Chatterjee,
C.*; Pratt, M. R. Semisynthetic, site-specific ubiquitin modification of alpha-synuclein
reveals different effects on aggregation. J. Am. Chem. Soc. 2012, 134, 5468-5471.
6.
Fierz, B.; Chatterjee, C.; McGinty, R. K.; Bar-Dagan, M.; Raleigh, D. P.; Muir, T. W.
Histone H2B ubiquitylation disrupts local and higher order chromatin compaction. Nat.
Chem. Biol. 2011, 7, 113-119.
7.
Chatterjee, C.; McGinty, R. K.; Fierz, B.; Muir, T. W. Disulfide-directed histone
ubiquitylation reveals plasticity in hDot1L activation. Nat. Chem. Biol. 2010, 6, 267-269.
8.
McGinty, R. K.; Kohn, M.; Chatterjee, C.; Chiang, K. P; Pratt, M. R.; Muir, T. W. Structure
activity analysis of semisynthetic nucleosomes: Mechanistic insights of the stimulation of
Dot1L by ubiquitylated histone H2B. ACS Chem. Biol. 2009, 4, 258-268.
9.
Levengood, M. R.; Kerwood, C. C.; Chatterjee, C.; van der Donk, W. A. Investigations of
the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids.
ChemBioChem 2009, 10, 911-919.
10.
Patton, G. C.; Paul, M.; Cooper, L. E.; Chatterjee, C.; van der Donk, W. A. The importance
of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry
2008, 47, 7342-7351.
11.
Furgerson Ihnken, L. A.; Chatterjee, C.; van der Donk, W. A. In vitro reconstitution and
substrate specificity of a lantibiotic protease. Biochemistry 2008, 47, 7352-7363.
12.
Miller, L. M.; Menthena, A.: Chatterjee, C.; Verdier-Pinard, P.; Novikoff, P. Horwitz, S. B.;
Angeletti, R. H. Increased levels of a unique post-translationally modified βIVb-tubulin
isotype in liver cancer. Biochemistry 2008, 47, 7572-7582.
13.
McGinty, R. K.; Kim, J.; Chatterjee, C.; Roeder, R. G.; Muir, T. W. Chemically ubiquitylated
histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature 2008,
453, 812-816.
14.
Chatterjee, C.; McGinty, R. K.; Pellois, J.-P.; Muir, T. W. Auxiliary-mediated site-specific
peptide ubiquitylation. Angew. Chem. Int. Ed. Engl. 2007, 46, 2814-2818.
15.
Chatterjee, C. (Co-first author); Patton, G. C. (Co-first author); Cooper, L.; Paul, M.; van
der Donk, W. A. Engineering dehydro amino acids and thioethers into peptides using
Lacticin 481 synthetase. Chem. Biol. 2006, 13, 1109-1117.
16.
Miller, L. M.; Chatterjee, C.; van der Donk, W. A.; Kelleher, N. L. The dehydratase activity
of Lacticin 481 synthetase is highly processive J. Am. Chem. Soc. 2006, 128, 1420-121.
17.
Chatterjee, C.; Miller, L. M.; Leung, Y. L.; Xie, L.; Yi, M.; Kelleher, N. L.; van der Donk, W.
A. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J.
Am. Chem. Soc. 2005, 127, 15332-15333.
18.
Xie, L.; Miller, L. M.; Chatterjee, C.; Averin, O.; Kelleher, N. L.; van der Donk, W. A.
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science 2004, 303,
679-681.
19.
Xie, L.; Chatterjee, C.; Balsara, R.; Okeley, N.M.; van der Donk, W.A. Heterologous
expression and purification of SpaB involved in subtilin biosynthesis Biochem. Biophys.
Res. Commun. 2002, 295, 952-957.
REVIEW ARTICLES: (* denotes as a P.I. at UW)
20. Dhall, A.; Chatterjee, C.* Chemical approaches to understand the language of histone
modifications ACS Chem. Biol. 2011, 6, 987-999.
21.
McGinty, R.K.; Chatterjee, C.; Muir, T.W. Semisynthesis of ubiquitylated proteins Methods
Enzymol. 2009, 462, 225-243.
22.
Chatterjee, C.; Paul, M.; Xie, L.; van der Donk, W.A. Biosynthesis and mode of action of
lantibiotics Chem. Rev. 2005, 105, 633-683.
Champak Chatterjee
Curriculum Vitae
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INVITED REVIEWS AND BOOK CHAPTERS: (* denotes as a P.I. at UW)
23.
Weller, C.E.; Pilkerton, M.E.; Chatterjee, C.* Chemical strategies to understand the
language of ubiquitin signaling Biopolymers 2014, 101, 144-155. (For Special Issue: The
Next Frontier of Post-translational Modifications)
24.
Chatterjee, C.; Muir, T.W. Chemical approaches for studying histone modifications J. Biol.
Chem. 2010, 285, 11045-11050. (For Special Series: Chemical Biology Meets Biological
Chemistry)
25.
Dhall, A.; Chatterjee, C.* “Chapter 8: Genetic and chemical approaches to study histone
modifications” in Epigenetic Technological Applications, Y. George Zheng Ed., Elsevier Press (part of the book series Translational Epigenetics edited by Trygve Tollefsbol)
INVITED PRESENTATIONS (AS A UW FACULTY MEMBER)
1.
2015 University of Wisconsin at Madison, Department of Chemistry
2.
2015 Pennsylvania State University, Department of Chemistry
3.
2015 The Fred Hutchinson Cancer Research Center, Basic Sciences Division
4.
2015 The Scripps Research Institute, Department of Chemistry
5.
2015 University of Michigan, Department of Chemistry
6.
2015 University of California San Francisco, Cellular and Molecular Pharmacology
7.
2015 Stanford University, Department of Chemistry
8.
2015 Temple University, Department of Chemistry
9.
2015 University of Pennsylvania, Department of Chemistry
10. 2015 Albert Einstein College of Medicine, Department of Biochemistry
11. 2015 New York University, Department of Chemistry
12. 2015 Southern Illinois University, Department of Molecular Biology and Microbiology
13. 2015 The Johns Hopkins University School of Medicine, Pharmacology
14. 2015 University of Southern California, Department of Chemistry
15. 2015 University of Illinois at Urbana-Champaign, Department of Chemistry
16. 2015 University of North Carolina, Chapel Hill, Lineberger Comprehensive Cancer Center
17. 2015 Northwestern University, Chemistry of Life Processes Institute
18. 2015 Wayne State University, Department of Chemistry
19. 2015 University of Pittsburgh, Department of Chemistry
20. 2015 Colorado State University, Department of Chemistry and Biochemistry
21. 2014 Oregon Health & Science University, Department of Physiology and Pharmacology
22. 2014 University of Washington, Department of Pharmacology
23. 2014 Tufts University, Boston, Department of Chemistry
24. 2014 Brandeis University, Boston, Department of Chemistry
25. 2014 Boston College, Department of Chemistry
26. 2014 Washington State University, Department of Chemistry
27. 2014 Young Investigators Symposium, ACS Division of Medicinal Chemistry
28. 2014 Texas A&M, Department of Biochemistry and Biophysics
29. 2014 University of Massachusetts, Amherst, Department of Chemistry
30. 2014 Presidency University, Kolkata, India
31. 2013 Carleton College, Macalester College and St. Olaf College, Depts. of Chemistry
32. 2013 ACS NORM, Biochemistry Symposium, Corvallis, OR
33. 2013 Bioorganic Gordon Research Conference, Andover, NH
34. 2012 Bioorganic Gordon Research Conference, Andover NH (invited poster)
Champak Chatterjee
Curriculum Vitae
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35.
36.
37.
2012 Seattle University, Department of Chemistry
2012 Iowa State University, Dept. of Biochemistry, Biophysics and Molecular Biology
2011 Pacific Lutheran University, Department of Chemistry
SELECTED PRESENTATIONS PRIOR TO JOINING UW
1. 2010 University of Minnesota, Department of Chemistry Seminar
2. 2009 Caltech, Division of Chemistry and Chemical Engineering Seminar
3. 2009 New York University, Department of Chemistry Seminar
4. 2009 University of Pittsburgh, Department of Chemistry Seminar
5. 2009 University of Washington, Department of Chemistry Seminar
6. 2009 University of Illinois at Urbana-Champaign, Chemical Biology Seminar
7. 2009 238th ACS National Meeting, Washington D.C., Organic Chemistry Division
8. 2009 Gordon Research Conference on Enzymes, Coenzymes & Metabolic Pathways
(poster)
HIGHLIGHTED RESEARCH:
1.
Talk among histones, Nature Methods 2008, 5, 662-663.
2.
Chemical answers to epigenetic crosstalk Nature Chemical Biology 2008, 4, 335-337.
3.
A synthetic kiss of death ChemBioChem 2007, 8, 1221-1223.
4.
Toward novel lantibiotics Chemical and Engineering News 2004, 82(5), 10.
PATENTS:
Van der Donk, W.A.; Xie, L.; Chatterjee, C.; Paul, M. Compositions and methods for dehydration
and cyclization of peptides, synthetic compounds, and lantibiotics. U.S. Patent US7785825.
RESEARCH SUPPORT
Completed:
Royalty Research Fund (P.I.)
7/2012-7/2013
Title: Semi-synthetic Approaches to Investigate Chromatin Regulation by the Small Ubiquitin-like
Modifier Protein
Ongoing:
National Institutes of Health (P.I.)
5/2014-1/2019
Title: Chemical Strategies to Investigate Gene Regulation by Histone SUMOylation (R01)
PROFESSIONAL SERVICE
Professional and Leadership activities at the University of Washington
1.
Voting member, Faculty Council for Academic Standards, September 2015-2018
2.
Chemistry Graduate Recruiting Committee, 2010-present
3.
Chemistry Graduate Admissions Committee, 2010-present
4.
Chemistry Graduate Second-year Examination Committee 2010-present (14)
5.
Chemistry Graduate Supervisory Committee 2010-present (27)
6.
Chemistry Graduate Student Travel Award Committee 2012-present
7.
Biological Physics, Structure, and Design Program (BPSD), Graduate Admissions
Committee, 2013
Champak Chatterjee
Curriculum Vitae
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8.
9.
10.
11.
12.
13.
14.
Lecture: Protein Engineering, ChemE 599, 2012 & 2013.
Lecture: A Suicide Synthase in Thiamine Biosynthesis, BPSD 542, 2012 & 2013.
Lecture: A conformational switch in HP1 releases auto-inhibition to drive heterochromatin
assembly, BPSD 542, 2014.
Guest Academic, UW Postdoctoral Association Career Panel, 2012.
Reviewer, Amgen Fellowships and Mary Gates Undergraduate Research Scholarships,
2011-2014
Moderator, Amgen Scholars Program & HHMI EXROP Oral Presentations 2013 & 2014
Graduate School Representative (GSR) for Graduate Supervisory Committees in the
Departments of Biochemistry, Bioengineering and Medicinal Chemistry 2011-present (3)
Professional and Leadership Activities outside the University of Washington
1. Associate Editor, Computational and Structural Biotechnology Journal (CSBJ)
2. Ad-hoc manuscript review: Nature Communications, Chemical Communications (RSC),
ChemBioChem, Chemical Science (RSC), Organic and Biomolecular Chemistry (RSC),
Journal of the American Chemical Society, ACS Chemical Biology, Chemistry- A European
Journal, ACS Chemical Neuroscience, Journal of Mass Spectrometry, Neuropharmacology,
FEBS Letters, FEBS Journal, Analytical Biochemistry, Tetrahedron, Tetrahedron Letters and
CSBJ.
3. Ad-hoc grant proposal review: National Science Foundation (Chemistry of Life Processes),
National Institutes of Health (SBCB) and ACS Petroleum Research Fund.
Outreach and Educational Activities
1. Faculty Mentor, Amgen Scholars Program 2011-2014.
2. Middle School Outreach- Jane Addams & Aki Kurose, Seattle 2011-2012.
3. High School Outreach- Bishop Blanchett, Seattle 2014.
4. Faculty Mentor, Partners in Science Program for high-school teachers, 2013-2014.
Professional Organizations
1. American Chemical Society (Division of Medicinal Chemistry) 2000-present
2. American Society for Biochemistry and Molecular Biology
2014-present
TEACHING
Primary Teaching Assignments by Quarter (Adjusted Median Scores on a 5.0 point scale)
CHEM 239: Introductory Organic Chemistry (Undergraduate)
AU 2011 AU 2012
Course as a whole:
4.5
4.7
Course content:
4.3
4.7
Instructor’s contribution to the course:
5.1
5.0
Instructor's effectiveness in teaching the subject:
4.9
5.0
Combined items above:
4.7
4.9
AU2013
4.6
4.5
5.0
5.0
4.8
AU2014
4.7
4.6
5.1
5.1
5.0
CHEM 532: Advanced Organic Chemistry (Graduate)
SP 2011
Course as a whole:
4.4
Course content:
4.5
Instructor’s contribution to the course:
4.6
SP 2013
4.3
4.1
4.8
SP 2014
4.4
4.2
4.8
Champak Chatterjee
Curriculum Vitae
SP 2012
3.8
4.0
4.0
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Instructor's effectiveness in teaching the subject:
Combined items above:
4.4
4.5
4.0
4.0
4.7
4.5
4.4
4.4
RESEARCH MENTORING
Current Ph.D. Students
Patrick Shelton
Nicholas Senger
Samuel Whedon
Caroline Weller
Abhinav Dhall
06/2014–present
01/2014–present
01/2013–present
01/2012–present
01/2011–present
Current M.S. Students
Christa Kasdorf
10/2014-present (Research Masters)
Ian Eustis
01/2014–06/2015 (Classwork Masters)
Meagan Pilkerton
01/2012-06/2015 (Classwork Masters)
Current Undergraduate
Priscilla Kwong
Peng Gang
Jiantong Zhang
Students
01/2015-present
01/2015-present
01/2015-present
Past Members
Fomer Postdoctoral Research Associates
Dr. Markandeya Nagula 02/2012-02/2013 European Institute of Chemical Biology (Prof. Ivan Huc)
Dr. Aurea Chu
12/2011-06/2013 Baylor University (Prof. Michael Trakselis)
Dr. Yingquan Song
06/2011-09/2011 Zwitter Technology LLC, Seattle
Former Undergraduate
Denis Smirnov
Natalia Zakharova
Colin Jones
Claire Williams
Kalkena Sivanesam
Rudy Sharar
Brady Rohrig
Jessica Huang
Wei Huang
Champak Chatterjee
Students
01/2011-12/2012
06/2012-12/2012
06/2012-08/2012
06/2011-08/2011
06/2010-06/2012
07/2010-06/2011
07/2013–3/2014
05/2013–5/2014
05/2012–8/2014
University of Washington (Prof. John Neumaier)
Bastyr University
Willamette University
Grinnell College
University of Washington (Prof. Niels Andersen)
Teach for America (LPS Richmond, CA)
University of Washington
Medical School
Medical School
Curriculum Vitae
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