course outilne MedChem2015

University of Jordan
Faculty of Pharmacy
Department of Pharmaceutical Sciences
Course Title: Pharmaceutical Chemistry II & Practical
Course Code: 1201412 & 1201413
Pre-requisite: Pharmaceutical Chemistry I (1201411)
Course lecturers:
Dr. Ghadeer Isafan, section 1
Dr. Mutasem Taha, sections 2, 3
Dr. Areej Abuhammad , sections 4, 5, 6 (course coordinator)
I-Objectives
At the end of this course, the student is expected to have an introductory knowledge regarding the
chemical structures, pharmacodynamics, pharmacokinetics and physicochemical properties of
various chemotherapeutic, semisynthetic and natural antibiotic agents. The course emphasizes on
antibacterial, antifungal, antiprotozoal, antimalarial, anthelmenthic, antiviral and anticancer
agents.
II-Outlines
Topic
Week 1
Dr. Isafan
Week2
Dr. Isafan
Week 3
Dr. Taha
Week 4
Dr. Abuhammad
Week 5
Week 6
b-Lactam
Antibiotics
Cephalosporins
No. of lectures
Reference textbook
2 lectures
Patrick
2
Lectures
Patrick
Quinolones
2
Wilson and
Sufonamides
Lectures
Gisvold’s
Aminoglycosides
1 lecture
Wilson and
Macrolides
1 lecture
Gisvold’s
Dr. Abuhammad
Antituberculars
2 lectures
Dr. Abuhammad
Antifungals
2 lectures
Week 7
Wilson and
Gisvold’s
Wilson and
Gisvold’s
Midterm Exam
Week 8
Dr. Abuhammad
Week 9
Dr. Abuhammad
Antimalaria
1 lecture
Wilson and
Anthelminthics
1 lecture
Gisvold’s
Antivirals
2 lectures
Wilson and
Gisvold’s
Week 10
Week 11
Wilson and
Dr. Abuhammad
Antivirals
2 lectures
Dr. Abuhammad
Antiprotozoal
1 lecture
Wilson and
Dr. Taha
Tetracyclines
1 lecture
Gisvold’s
Lincomycin
1 lecture
Wilson and
Misc.antibiotics
1 lecture
Gisvold’s
Anticancer
2
Wilson and
agents
Lectures
Gisvold’s
Anticancer
2
Wilson and
agents
Lectures
Gisvold’s
Week 12
Dr. Taha
Week 13
Dr. Taha
Week 14
Dr. Taha
Week 15
Gisvold’s
Final Exam
III-Evaluation
The students are to be evaluated through three exams: Midterm Exam (40%), Quiz (10%) and
Final Exam (50%).
IV-Text Book:
Wilson and Gisvold's Textbook of Organic, Medicinal and Pharmaceutical Chemistry, 10th
Edition. Delgado, J.N.; Remers, W.A.
Principles of Medicinal Chemistry, 4th Edition. Foye, W.O.; Lemke, T.L.; Williams, D.A.
An Introduction to Medicinal Chemistry, 3rd edition; Graham L. Patrick;
Oxford University Press Inc., New York, 2005
V- Intended Learning Outcomes:Successful completion of this module should lead to the following outcomes:A- knowledge and understanding (students should) :A1) Be able to discuss the structure activity relationships (SAR) that control
the pharmacokinetics (drug absorption, distribution, metabolism and
excretion) and pharmacodynamics (mechanism of action of drug with
respective receptor) of significant fraction of clinically applicable
antibacterial (synthetic and natural antibiotics), antifungal (synthetic and
natural antibiotics), antiprotozoal (in particular antimalarials,
antiamebics), anthelmenthics, antivirals and antineoplastic agents.
A2) Be able to predict qualitatively pharmacokinetic and pharmacodynamic
properties of various chemotherapeutic agents from molecular structures.
B) Intellectual Skills-With ability to:B1)
Employ acquired background knowledge (i.e., SAR) as appropriate for
understanding drug-drug interactions and some side effects of
B2)
chemotherapeutic agents.
Employ acquired background knowledge as appropriate for
understanding and suggesting appropriate clinically suitable combinations of chemotherapeutic
agents intended to overcome microbial or neoplastic resistance and/or to reduce side effects.
C) Practical Skills-with ability to (in the laboratory Sessions): C1)
Employ theoretical organic chemistry knowledge for the synthesis of
medicinal compounds.
C2)
Employ background knowledge in purification techniques (i.e., crystallization) for purifying
chemical structures during synthesis.
C3)
Employ analytical techniques, i.e., infrared spectroscopy, thin layer chromatography and nuclear
magnetic resonance (Demo), for characterizing chemical structures during synthetic steps.
D) Transferable skills-with ability to:D1) Acquire “clinical-chemical” intuition by which the student can associate the chemotherapeutic
properties of certain medicinal agent and its corresponding chemical structure.
D2) Think in a multidisciplinary way through which the student can venture smoothly within the HostMicrobe (or parasite or cancer cell) - Antimicrobial agent (or anticancer) triangle.