Cost Comparison Charts - April 2015

Transcription

Cost Comparison Charts - April 2015
REGIONAL DRUG AND THERAPEUTICS CENTRE
(NEWCASTLE)
COST COMPARISON CHARTS
April 2015
16/17 Framlington Place
Newcastle upon Tyne
NE2 4AB
INTRODUCTION
Charts are organised by BNF classification and show comparative costs at basic
NHS prices (as of April 2015) for selected agents. Except where indicated otherwise,
each chart shows the cost of 1 year1 of treatment at a standard daily dose (shown in
brackets). The doses given are not intended to imply therapeutic equivalence and for
some drug groups – such as ACE inhibitors – doses may vary according to
indication. Additionally, in some therapeutic areas – such as antibacterial drugs – the
duration of treatment may differ from that shown.
NEW - Cost comparison charts are now available in Excel format to all stakeholders
(under password protection) on our NHS website: http://rdtc.nhs.uk/
The contents table on the following page has been formatted so that you can quickly
navigate to specific charts by holding the cursor over the chart title and clicking your
left mouse button whilst holding down the “Ctrl” key.
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
1
1 year in this case is equal to 364 days rather than 365 when 1 month equals 28 days.
Regional Drug and Therapeutics Centre
Cost comparison charts
To navigate to the chart required, hover the cursor over the section required, press CTRL
and click with the left mouse button.
CONTENTS by BNF classification
Page
1.1.1 Dyspepsia and gastro-oesophageal reflux disease ............................................................. 4
1.2 Antispasmodics and other drugs altering gut motility.............................................................. 4
1.3 Antisecretory drugs and mucosal protectants ......................................................................... 5
1.4 Acute Diarrhoea ...................................................................................................................... 6
1.6 Laxatives ................................................................................................................................. 6
2.2 Diuretics .................................................................................................................................. 7
2.4 Beta-adrenoceptor blocking drugs .......................................................................................... 8
2.5.4 Alpha-adrenoceptor blocking drugs ..................................................................................... 8
2.5.5 Drugs affecting the renin-angiotensin system ...................................................................... 9
2.6.1/2.6.3 Nitrates and other antianginal drugs ......................................................................... 10
2.6.2 Calcium-channel blockers .................................................................................................. 11
2.8.2 Oral anticoagulants ............................................................................................................ 12
2.9 Antiplatelet drugs .................................................................................................................. 12
2.12 Lipid-regulating drugs.......................................................................................................... 13
3.1 Bronchodilators ..................................................................................................................... 14
3.2 Corticosteroids ...................................................................................................................... 15
3.2 Corticosteroid & bronchodilator inhalers ............................................................................... 16
3.1 & 3.2 Inhaled therapy licensed for COPD ............................................................................. 17
3.3 Cromoglicate & related therapy, leukotriene receptor antagonists, and phosphodiesterase
type-4 inhibitors ........................................................................................................................... 17
3.4.1 Antihistamines .................................................................................................................... 18
4.1 Hypnotics & anxiolytics.......................................................................................................... 18
4.2 Atypical antipsychotics – maintenance doses (adults with psychosis) .................................. 19
4.2 Atypical antipsychotics – Low doses ..................................................................................... 20
4.3 Antidepressant drugs ............................................................................................................ 21
4.5 Drugs used in the treatment of obesity ................................................................................. 22
4.6 Drugs used in nausea and vertigo ........................................................................................ 22
4.7 Analgesics ............................................................................................................................. 23
4.7.2 Opioid analgesics ............................................................................................................... 24
4.7.2 MR Opioid analgesics ........................................................................................................ 25
4.7.2 Strong opioid analgesics – equipotent dose cost per 24 hours ......................................... 26
4.7.3 Neuropathic pain ................................................................................................................ 27
4.7.4.1 Antimigraine drugs (acute) .............................................................................................. 27
4.8 Antiepileptic drugs ................................................................................................................. 28
4.10.2 Nicotine dependence ....................................................................................................... 29
4.11 Drugs for dementia ............................................................................................................. 30
5 Miscellaneous antimicrobial and anthelmintic drugs ................................................................ 31
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5.1.1 Penicillins ........................................................................................................................... 31
5.1.2 Cephalosporins .................................................................................................................. 32
5.1.3 Tetracyclines ...................................................................................................................... 32
5.1.12 Quinolones ....................................................................................................................... 33
5.2 Miscellaneous antifungal drugs (including topical and gynaecological) ................................ 33
6.1.1 Insulins (prefilled pens and cartridges) .............................................................................. 34
Needles For Pre-Filled And Reusable Insulin Pens .................................................................... 35
Blood lancets............................................................................................................................... 36
6.1.6 Blood glucose monitoring ................................................................................................... 37
6.1.2 Antidiabetic drugs............................................................................................................... 38
6.1.2 Antidiabetic drugs – Newer agents .................................................................................... 39
6.6.2 Bisphosphonates and other drugs affecting bone metabolism .......................................... 39
7.3 Contraceptives – Combined hormonal contraceptives ......................................................... 40
7.3 Contraceptives – Progestogen-only contraceptives .............................................................. 41
7.4.1 Drugs for urinary retention ................................................................................................. 42
7.4.2 Drugs for urinary frequency, enuresis and incontinence .................................................... 43
7.4.5 Drugs for erectile dysfunction ............................................................................................ 44
9.6.4 Calcium and vitamin D ....................................................................................................... 44
10.1.1 Non-steroidal anti-inflammatory drugs ............................................................................. 45
10.3.2 Rubefacients, topical NSAIDs, capsaicin, and poultices .................................................. 46
11.6 Treatment of Glaucoma ...................................................................................................... 47
11.8.1 Tear Deficiency, Ocular Lubricants, and Astringents ....................................................... 48
12.2.1 Nasal steroids .................................................................................................................. 48
13.2.1 Emollients (by volume) ..................................................................................................... 49
13.2.1 Emollients per 100g/ml .................................................................................................... 50
13.2.1.1 Emollient bath and shower preparations per 100g/ml ................................................... 51
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1.1.1 Dyspepsia and gastro-oesophageal reflux disease
April 2015: Dyspepsia and gastro-oesophageal reflux disease - cost of 1 year's treatment
Maalox Plus® (30 ml)
£85.18
Compound alginate suspension
(Gastrocote® 40 ml)
£77.75
Compound alginate suspension
(Gaviscon Advance® 20 ml)
£74.55
Co-magaldrox 195/220 suspension
(Maalox® 30 ml)
£73.16
Compound alginate suspension
(Acidex® 40 ml)
£72.80
Magnesium Trisilicate suspension (30
ml)
£69.89
Co-magaldrox 195/220 suspension
(Mucogel® 30 ml)
£65.30
Compund alginate suspension
(Peptac® 40 ml)
£56.78
Asilone® (30 ml)
£42.59
£0
Doses given do not imply therapeutic equivalence
£10
£20
£30
£40
£50
£60
£70
£80
£90
copyright © RDTC 2015
1.2 Antispasmodics and other drugs altering gut motility
April 2015: Antispasmodics and other drugs altering gut motility - cost of 1 year's treatment
Dicycloverine (30 mg)
£1,167.68
Fybogel Mebeverine® sachets (1 BD)
£284.65
Alverine (60 mg TDS)
£212.83
Propantheline (15 mg TDS)
£202.22
£156.00
Hyoscine butylbromide (20 mg QDS)
Peppermint oil (Colpermin®) capsules
(1 TDS)
£133.01
Kolanticon® gel (40 ml)
£114.73
Mebeverine (135 mg TDS)
£92.16
Peppermint oil (Mintec®) capsules (1
TDS)
£91.52
Mebeverine MR (200 mg BD)
£83.96
£0
Doses given do not imply therapeutic equivalence
£200
£400
£600
£800
£1,000
£1,200
£1,400
copyright © RDTC 2015
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1.3 Antisecretory drugs and mucosal protectants
April 2015: Antisecretory drugs and mucosal protectants - cost of
1 year's treatment
Famotidine (40 mg OD)
£502.19
Misoprostol (200
micrograms QDS)
£243.39
Nizatidine (300 mg OD)
£187.22
Sucralfate (1 g QDS)
£185.20
Losec® tablets (20 mg
OD)
£150.80
Omeprazole tablets (20
mg OD)
£79.43
Lansoprazole tablets (30
mg OD)
Esomeprazole (20 mg
OD)
Rabeprazole (20 mg OD)
£70.20
£48.10
£38.48
Cimetidine (400 mg BD)
£21.35
Pantoprazole (40 mg OD)
£20.67
Lansoprazole capsules
(30 mg OD)
£19.76
Ranitidine (150 mg BD)
£19.05
Ranitidine (300 mg OD)
£17.96
Omeprazole capsules (20
mg OD)
£15.99
£0
£100
Doses given do not imply therapeutic equivalence
£200
£300
£400
£500
£600
copyright © RDTC 2015
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Cost comparison charts
1.4 Acute Diarrhoea
April 2015: Acute diarrhoea - cost of 5 days treatment
£6.74
Racecadotril 100mg capsules
£4.51
Co-phenotrope 2.5mg/0.025mg tablets
Loperamide 2mg capsules
£2.23
Loperamide 2mg tablets
£1.51
Codeine 30mg tablets
£1.09
£0
£1
£2
£3
£4
£5
£6
£7
Doses given do not imply therapeutic equivalence
£8
copyright © RDTC 2015
1.6 Laxatives
April 2015: Laxatives - cost of 14 days treatment
Prucalopride 2 mg (Resolor®)
£29.76
Lubiprostone 24mcg (Amitiza® 2 daily)
£26.74
Linaclotide 290mcg (Constella®)
£18.78
Sodium citrate enema (Micolette® 1 daily)
£5.78
Macrogols (Movicol® 2 sachets for 14 days)
£3.99
Macrogols (Laxido® Orange 2 sachets for 14 days)
£3.99
Sodium picosulfate 2.5 mg (4 capsules)
£3.21
Sodium picosulfate 5 mg/5 ml oral solution (10 ml)
£3.12
Manevac® (8 g)
£2.66
Glycerol suppository (4 g)
£2.26
Ispaghula husk (Fybogel® 2 sachets)
£2.14
Docusate (200 mg)
£1.95
Sterculia (Normacol® 10 g)
£1.92
Lactulose (20 ml)
£1.80
Senna (15 mg)
£1.64
Methylcellulose (2 g)
£1.61
Bisacodyl (10 mg)
£1.07
£0
Doses given do not imply therapeutic equivalence
£5
£10
£15
£20
£25
£30
£35
copyright © RDTC 2015
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Cost comparison charts
2.2 Diuretics
April 2015: Diuretics - cost of 1 year's treatment
Eplerenone (50 mg)
£512.07
Triamterene (50 mg)
£338.76
Chlortalidone (50 mg)
£195.95
Torasemide (5 mg)
£188.37
Amiloride (5 mg)
£143.26
Co-amilofruse 5/40 (1
tablet)
Xipamide (20 mg)
Indapamide MR (1.5 mg)
Spironolactone (100 mg)
£66.17
£50.60
£41.25
£31.72
Spironolactone (25 mg)
£20.41
Indapamide (2.5 mg)
£20.28
Bumetanide (1 mg)
£17.55
Co-amilozide 5/50 (1
tablet)
£16.12
Co-triamterzide 50/25 (1
tablet)
£11.53
Furosemide (40 mg)
£11.44
Bendroflumethiazide (2.5
mg)
£11.18
£0
£100
Doses given do not imply therapeutic equivalence
£200
£300
£400
£500
£600
copyright © RDTC 2015
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Cost comparison charts
2.4 Beta-adrenoceptor blocking drugs
April 2015: Beta-adrenoceptor blocking drugs - cost of 1 year's treatment
Timolol (10 mg BD)
£258.68
Acebutolol (400 mg OD)
£242.06
Labetalol (200 mg TDS)
£192.86
Oxprenolol (40 mg QDS)
£187.72
Pindolol (15 mg OD)
£137.15
Nadolol (160 mg OD)
£130.00
Sotalol (160 mg OD)
£76.83
Propranolol (40 mg TDS)
£61.62
Celiprolol (200 mg OD)
£50.44
Metoprolol (50 mg TDS)
£42.51
Nebivolol (5 mg OD)
£20.54
Carvedilol (25 mg OD)
£19.11
Bisoprolol (10 mg OD)
£13.26
Atenolol (50 mg OD)
£12.09
£0
£50
£100
£150
£200
£250
Doses given do not imply therapeutic equivalence
£300
copyright © RDTC 2015
2.5.4 Alpha-adrenoceptor blocking drugs
April 2015: Alpha-adrenoceptor blocking drugs - cost of 1 year's treatment
Indoramin (100 mg)
£1,044.51
Prazosin (5 mg)
£104.95
Doxazosin MR (4 mg)
£65.00
Terazosin (5 mg)
£36.40
Doxazosin (4 mg)
£14.56
Doxazosin (2 mg)
£12.35
£0
Doses given do not imply therapeutic equivalence
£200
£400
£600
£800
£1,000
£1,200
copyright © RDTC 2015
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Cost comparison charts
2.5.5 Drugs affecting the renin-angiotensin system
April 2015: Drugs affecting the renin-angiotensin system - cost of
1 year's treatment
£371.28
Aliskiren (300 mg)
Azilsartan medoxomil (40mg)
£218.40
Eprosartan (600 mg)
£186.03
Olmesartan (20 mg)
£168.35
Trandolapril (2 mg)
£98.80
Imidapril (10 mg)
£93.86
Moexipril (15 mg)
£90.48
Valsartan (80 mg)
£86.45
£76.20
Perindopril arginine (5 mg)
Fosinopril (10 mg)
£26.39
Quinapril (20 mg)
£24.18
Irbesartan (150 mg)
£20.80
Telmisartan (40 mg)
£19.37
Perindopril erbumine (4 mg)
£18.93
Captopril (25 mg BD)
£16.90
Ramipril capsules (5 mg)
£16.12
Losartan (50 mg)
£15.99
Candesartan (8 mg)
£15.99
Ramipril tablets (5 mg)
£14.95
Enalapril (10 mg)
£13.26
Lisinopril (10 mg)
£13.13
£0
£50
Doses given do not imply therapeutic equivalence
£100
£150
£200
£250
£300
£350
£400
copyright © RDTC 2015
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Cost comparison charts
2.6.1/2.6.3 Nitrates and other antianginal drugs
April 2015: Nitrates and other antianginal drugs - cost of 28 days
treatment
Ranolazine (375mg,
500mg, 750mg BD)
£45.71
Ivabradine (10 mg)
£40.17
Isosorbide dinitrate (20
mg QDS)
£28.76
Transiderm Nitro® (5
mg/24 hours)
£17.05
Deponit® (5 mg/24 hours)
£12.77
Minitran® (5 mg/24
hours)
£10.85
Nitro-Dur® (5 mg/24
hours)
£10.59
Isosorbide mononitrate
MR tabs (60 mg)
£10.50
Isosorbide mononitrate
MR caps (60 mg)
£8.86
Nicorandil (20 mg BD)
£7.00
Isosorbide mononitrate
(40 mg BD)
Glyceryl trinitrate (500
mcg, 100 tablets)
£6.19
£2.08
Nitrolingual® spray (200
dose)
£0.48
Glytrin® spray (200 dose)
£0.46
Nitromin® spray (200
dose)
£0.38
£0
£5
£10
Doses given do not imply therapeutic equivalence
£15
£20
£25
£30
£35
£40
£45
£50
copyright © RDTC 2015
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Cost comparison charts
2.6.2 Calcium-channel blockers
April 2015: Calcium-channel blockers - cost of 1 year's treatment
£343.85
Diltiazem MR tablets (60 mg TDS)
Dilzem XL® (180 mg)
£150.15
Dilzem SR® (90 mg BD)
£146.77
Adizem XL® (180 mg)
£134.81
Nifedipine MR tabs (Adalat Retard®, 20 mg BD)
£114.53
Adizem SR® (90 mg BD)
£110.50
Viazem XL® (180 mg)
£95.68
Tildiem Retard® (90 mg BD)
£94.51
Nifedipine MR tablets (Adalat LA®, 30 mg)
£89.05
Nicardipine (30 mg BD)
£82.81
Zemtard XL® (180 mg)
£68.51
Nifedipine MR capsules (20 mg BD)
£65.64
£54.73
Felodipine MR (5 mg)
Verapamil (120 mg BD)
£47.06
Lacidipine (4 mg)
£39.52
Lercanidipine (10 mg)
£20.41
Amlodipine (5 mg)
£12.74
£0
Doses given do not imply therapeutic equivalence
£50
£100
£150
£200
£250
£300 £350 £400
copyright © RDTC 2015
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Cost comparison charts
2.8.2 Oral anticoagulants
April 2015: Oral anticoagulants - cost of 1 year's treatment
Dabigatran (Pradaxa®) 150mg capsules (BD)
£799.59
Apixaban (Eliquis®) 5mg (BD)
£799.50
Apixaban (Eliquis®) 2.5mg (BD)
£799.34
Dabigatran (Pradaxa®) 110mg capsules (BD)
£799.34
Dabigatran (Pradaxa®) 75mg capsules (BD)
£799.34
Rivaroxaban (Xarelto®) 10mg tablets (OD)
£764.40
Rivaroxaban (Xarelto®) 15mg tablets (OD)
£764.40
Rivaroxaban (Xarelto®) 20mg tablets (OD)
£764.40
Warfarin 500microgram tablets (OD)
£21.58
Warfarin 5mg tablets (OD)
£14.04
Warfarin 3mg tablets (OD)
£13.91
Warfarin 1mg tablets (OD)
£13.52
£0
£100
£200
£300
£400
£500
£600
£700
£800
£900
copyright © RDTC 2015
Doses given do not imply therapeutic equivalence
Contents
2.9 Antiplatelet drugs
April 2015: Antiplatelet drugs - cost of 1 year's treatment
Ticagrelor (90mg BD)
£709.80
Prasugrel (10mg OD)
£618.28
Prasugrel (5mg OD)
£618.28
Dipyridamole MR (200mg BD)
£122.06
Asasantin Retard® (Aspirin
25mg/Dipyridamole MR 200mg BD)
£119.39
Clopidogrel (75mg OD)
£23.66
Aspirin EC (75mg OD)
£12.22
Aspirin Dispersible (75mg OD)
£11.31
£0
Doses given do not imply therapeutic equivalence
£100
£200
£300
£400
£500
£600
£700
£800
copyright © RDTC 2015
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Cost comparison charts
2.12 Lipid-regulating drugs
April 2015: Lipid-regulating drugs - cost of 1 year's treatment
Ciprofibrate (100 mg)
£1,367.73
Colesevelam (6 tablets)
£1,166.01
Colestipol (20 g)
£730.43
Colestyramine sugar free (12 g)
£695.60
Simvastatin (80 mg) / Ezetimibe (10 mg)
£535.73
Omega-3 Marine Triglycerides (10 g)
£532.90
Simvastatin (40 mg) / Ezetimibe (10 mg)
£506.74
Gemfibrozil (1.2 g)
£454.22
Simvastatin (20 mg) / Ezetimibe (10 mg)
£434.46
Rosuvastatin (40mg)
£385.97
Acipimox (500 mg)
£374.76
Ezetimibe (10 mg)
£342.03
Rosuvastatin (20mg)
£338.26
Atorvastatin chewable tablets (20mg)
£320.32
Rosuvastatin (5, 10 mg)
£234.39
Nicotinic acid (1g) / Laropiprant (20mg)
£217.49
Fenofibrate (200 mg)
£189.41
Atorvastatin chewable tablets (10mg)
£167.44
Bezafibrate MR (400 mg)
£92.58
Fenofibrate (160 mg)
£86.97
Fluvastatin (40 mg)
£35.36
Atorvastatin (80mg)
£35.23
Fluvastatin (20mg)
£32.24
Simvastatin (80 mg)
£26.13
Pravastatin (40 mg)
£25.09
Atorvastatin (40mg)
£20.67
Pravastatin (20 mg)
£20.41
Atorvastatin (20 mg)
£18.33
Atorvastatin (10 mg)
£15.34
Simvastatin (40 mg)
£14.82
Simvastatin (20 mg)
£13.26
£0
Doses given do not imply therapeutic equivalence
£200
£400
£600
£800
£1,000
£1,200 £1,400 £1,600
copyright © RDTC 2015
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Cost comparison charts
3.1 Bronchodilators
April 2015: Bronchodilators - cost of 1 year's treatment
Indacaterol/glycopyrronium Breezhaler® DPI
(85mcg/43mcg, 1 act OD)
£447.48
Tiotropium Handihaler® refill DPI (18 mcg)
£406.47
Tiotropium Respimat® Soft Mist (5 mcg OD)
£406.47
Aclidinium /formoterol Genuair® DPI (340mcg/12mcg, 1
act BD)
£394.33
Vilanterol/Umeclidinium Ellipta® DPI (22mcg/55mcg, 1
act OD)
£394.33
Indacaterol inhalation powder caps DPI (150 mcg, 1
act)
£355.02
Salmeterol inhaler MDI (25 mcg, 2 act BD)
£355.02
Salmeterol Accuhaler® DPI (50 mcg BD)
£355.02
Aclidinium Genuair® DPI (322 mcg, 1 act BD)
£347.01
Umeclidinium Ellipta® DPI (65mcg, 1 act OD)
£333.67
Glycopyrronium Breezhaler® DPI (50mcg, 1 act)
£333.67
£319.71
Olodaterol Respimat® SoftMist (2.5mcg, 2act OD)
£300.91
Formoterol Turbohaler® DPI (6 mcg BD)
£144.08
Formoterol Easyhaler® (12 mcg, 1 act BD)
£100.76
Terbutaline Turbohaler® DPI (500 mcg, 1 act QDS)
Salamol Easi-Breathe® MDI (100 mcg, 2 act QDS)
£91.73
Airomir Autohaler® MDI (100 mcg, 2 act QDS)
£87.65
Ipratropium inhaler MDI (20 mcg, 2 act QDS)
£80.95
Salbutamol dry powder inhaler DPI (200 mcg, 1 act
QDS)
£72.80
£28.68
Airomir® inhaler MDI (100 mcg, 2 act QDS)
Ventolin Evohaler® MDI (100 mcg, 2 act QDS)
£21.84
Salbutamol inhaler CFC-free MDI (100 mcg, 2 act QDS)
£21.84
Doses given do not imply therapeutic equivalence
£0
£50
£100
£150
£200
£250
£300
£350
£400
£450
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copyright © RDTC 2015
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
3.2 Corticosteroids
April 2015: Corticosteroids - cost of 1 year's treatment
Fluticasone Evohaler® (250 mcg, 2 act BD)
£438.50
Fluticasone Accuhaler® (500 mcg, 1 act BD)
£438.50
Fluticasone Evohaler® (125 mcg, 2 act BD)
£257.95
Fluticasone Accuhaler® (250 mcg, 1 act BD)
£257.95
Fluticasone Evohaler® (250 mcg, 1 act BD)
£219.25
Budesonide 400 Turbohaler® (1 act BD)
£128.93
Qvar 100 Easi-Breathe® (2 act BD)
£123.40
Clenil Modulite® inhaler (250 mcg, 2 act BD)
£118.59
Mometasone Twisthaler® (400 mcg 1 act)
£218.70
£201.80
Budesonide inhaler (200 mcg, 1 act BD)
Ciclesonide inhaler (160 mcg, 1 act)
£117.15
Fluticasone Accuhaler® (100 mcg, 1 act BD)
£108.35
£86.20
Budesonide 200 Turbohaler® (1 act BD)
Asmabec 100 Clickhaler® (2 act BD)
£71.42
Fluticasone Evohaler® (50 mcg, 2 act BD)
£66.01
Easyhaler® Budesonide (200mcg, 1 act BD)
£64.46
Qvar 100® inhaler (1 act BD)
£62.64
Qvar 50® inhaler (2 act BD)
£57.29
Qvar 50 Easi-Breathe® (2 act BD)
£56.35
Easyhaler® Beclomethasone (200mcg, 1 act BD)
£54.35
Clenil Modulite® inhaler (100 mcg, 2 act BD)
£54.02
£0
Doses given do not imply therapeutic equivalence
Step 2
High dose 0.8 - 1.0 mg
BDP eq /day
£201.80
Easyhaler® Budesonide (400mcg, 1 act BD)
Step 2
Very high
dose 2.0 mg BDP
eq /day
£100
Step 2
Standard
dose 0.4mg BDP
eq /day
£200
£300
£400
£500
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Cost comparison charts
3.2 Corticosteroid & bronchodilator inhalers
April 2015: ICS/LABA combination inhalers - Cost of treatment for
1 year
Symbicort 400/12 Turbohaler® DPI (2 act BD)
£922.13
DuoResp Spiromax 320/9 DPI (2 act BD)
£727.27
Seretide 250 Evohaler® MDI (2 act BD)
£721.69
Flutiform® 250/10 inhaler MDI (2 act BD)
1.6-2.0mg/day
B DP equivalent
Very High Do se
- A dult Step 4
£552.79
Seretide 500 Accuhaler® DPI (1 act BD)
£496.50
Relvar Ellipta® 184/22 inhaler DPI (1 act OD)
£471.62
Symbicort 200/6 Turbohaler® DPI (2 act BD)
£461.07
Symbicort 400/12 Turbohaler® DPI (1 act BD)
£461.07
Seretide 250 Accuhaler® DPI (1 act BD)
£424.67
Seretide 125 Evohaler® MDI (2 act BD)
£424.67
DuoResp Spiromax 320/9 DPI (1 act BD)
£363.64
DuoResp Spiromax 160/4.5 DPI (2 act BD)
£363.64
Fostair 100/6 MDI or NEXThaler® (2 act BD)
£355.75
Flutiform® 125/5 inhaler MDI (2 act BD)
£355.02
Relvar Ellipta® 92/22 inhaler DPI (1 act OD)
0.8-1.0mg/day
B DP equivalent
High Do se
- A dult Step 3
£337.31
Symbicort 100/6 Turbohaler® DPI (2 act BD)
£400.40
£230.53 Low dose LABA - 12mcg
Symbicort 200/6 Turbohaler® DPI (1 act BD)
Flutiform® 50/5 inhaler MDI (2 act BD)
£218.40
Seretide 50 Evohaler® MDI (2 act BD)
£218.40
Seretide 100 Accuhaler® DPI (1 act BD)
£218.40
DuoResp Spiromax 160/4.5 DPI (1 act BD)
0.4-0.5mg/day
B DP equivalent
Standard Do se
- A dult Step 3
£181.82
Fostair 100/6 MDI or NEXThaler® (1 act BD)
£177.87Low dose LABA - 12mcg
£0
Doses given do not imply therapeutic equivalence
£100
£200
£300
£400
£500
£600
£700
£800
£900
£1,000
copyright © RDTC 2015
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Cost comparison charts
3.1 & 3.2 Inhaled therapy licensed for COPD
April 2015: Inhaled therapy licensed for COPD (ICS/LABA combinations, LABAs, LAMAs &
LABA/LAMA combinations)
- Cost of treatment for 1 year
Fluticasone/salmeterol [Seretide Accuhaler®] 500/25 DPI (1 act BD)
£496.50
Budesonide/formoterol [Symbicort Turbohaler®] 400/12 DPI (1 act BD)
£461.07
Budesonide/formoterol [Symbicort Turbohaler®] 200/6 DPI (2 act BD)
£461.07
Indacaterol/glycopyrronium [Ultibro Breezhaler] 85/43 DPI (1 act OD)
£447.48
Tiotropium [Spiriva Handihaler®] refill DPI (18 mcg, 1 act OD)
£406.47
Umeclidinium/vilanterol [Anoro Ellipta®] 55/22 DPI (1 act OD)
£394.33
Aclidinium/formoterol [Duaklir Genuair®] 340/12 DPI (1 act BD)
£394.33
Budesonide/formoterol [DuoResp Spiromax] 160/4.5 DPI (2 act BD)
£363.64
Budesonide/formoterol [DuoResp Spiromax] 320/9 DPI (1 act BD)
£363.64
Beclometasone/formoterol [Fostair®] 100/6 MDI (2 act BD)
£355.75
Indacaterol [Onbrez Breezhaler®] DPI (150 mcg, 1 act)
£355.02
Salmeterol [Serevent Evohaler®] MDI (25 mcg, 2 act BD)
£355.02
Salmeterol [Serevent Accuhaler®] DPI (25 mcg, 2 act BD)
£355.02
Aclidinium [Eklira Genuair®] DPI (322 mcg, 1 act BD)
£347.01
Fluticasone furoate/vilanterol [Relvar Ellipta®] 92/22 DPI (1 act OD)
£337.31
Glycopyrronium [Seebri Breezhaler®] DPI (50mcg, 1 act OD)
£333.67
Umeclidinium [Incruse Ellipta®] DPI (65 mcg, 1 act OD)
£333.67
Olodaterol [Striverdi Respimat®] Soft Mist (2.5mcg, 2 act OD)
£319.71
Formoterol [Foradil®] inhalation powder DPI (12mcg, 1act BD)
£283.68
Formoterol modulite [Atimos®] MDI (12mcg, 1act BD)
£218.84
Formoterol Easyhaler® DPI (12 mcg, 1 act BD)
£144.08
£0
£100
£200
£300
£400
Doses given do not imply therapeutic equivalence
£500
£600
copyright © RDTC 2015
Contents
3.3 Cromoglicate & related therapy, leukotriene receptor antagonists, and
phosphodiesterase type-4 inhibitors
April 2015: Cromoglicate & related therapy, leukotriene receptor antagonists, and phosphodiesterase
type 4 inhibitors - cost of 1 year's treatment
£1,038.44
Nedocromil inhaler (2mg, 2 act QDS)
Intal Fisonair® inhaler (5mg, 2 act QDS)
£533.52
£457.55
Roflumilast (500mcg OD)
Zafirlukast (40mg)
£230.75
£200.72
Intal Spincaps® (20mg, 1 cap QDS)
Montelukast (10mg)
£28.60
£0
Doses given do not imply therapeutic equivalence
£200
£400
£600
£800
£1,000
£1,200
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Cost comparison charts
3.4.1 Antihistamines
April 2015: Antihistamines - cost of 1 year's treatment
Acrivastine (8 mg TDS)
£225.23
Cyproheptadine (4 mg TDS)
£218.04
Alimemazine (10 mg BD)
£155.74
Ketotifen (1mg BD)
£91.36
Mizolastine MR (10 mg)
£83.96
Clemastine (2 mg)
£60.67
Levocetirizine (5 mg)
£47.93
Fexofenadine (120 mg)
£43.44
Chlorphenamine (4 mg TDS)
£38.22
Promethazine (25 mg)
£30.23
Desloratadine (5 mg)
£21.48
Hydroxyzine (25 mg)
£15.86
Loratadine (10 mg)
£13.47
Cetirizine (10 mg)
£12.98
£0
£50
£100
£150
£200
Doses given do not imply therapeutic equivalence
£250
copyright © RDTC 2015
Contents
4.1 Hypnotics & anxiolytics
April 2015: Hypnotics and anxiolytics - cost of 14 days treatment
Buspirone 10 mg (TDS)
£10.74
Lormetazepam 1 mg
£9.76
Loprazolam 1 mg
£9.00
Clomethiazole capsules (2 ON)
£7.33
Melatonin MR 2 mg
£7.18
Temazepam 20 mg
£6.85
Chlordiazepoxide 10 mg (TDS)
£6.34
Zaleplon 10 mg
£3.76
Lorazepam 2.5 mg
£1.90
Oxazepam 15 mg (BD)
£1.54
Nitrazepam 5 mg
£0.92
Zopiclone 7.5 mg
£0.84
Zolpidem 10 mg
£0.79
Diazepam 10 mg
£0.62
£0
Doses given do not imply therapeutic equivalence
£2
£4
£6
£8
£10
£12
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Cost comparison charts
4.2 Atypical antipsychotics – maintenance doses (adults with psychosis)
April 2015: Atypical Antipsychotics – maintenance doses (adults
with psychosis) - cost of 1 year's treatment
£3,161.60
Paliperidone 12mg (9mg+3mg) OD
Aripiprazole 30mg OD
£2,393.04
Quetiapine 600mg MR OD
£2,062.67
Paliperidone 9mg OD
£1,896.96
Paliperidone 3mg OD
£1,264.64
Paliperidone 6mg OD
£1,264.64
Aripiprazole 15mg OD
£1,196.52
Lurasidone (Latuda®) 18.5mg – 74mg OD
£1,179.36
Asenapine (Sycrest®) 10mg OD
£622.44
Asenapine (Sycrest®) 5mg OD
£622.44
Risperidone 4mg (disp) OD
£493.35
Amisulpride 400mg BD
£438.13
Amisulpride 200mg BD
£117.21
Risperidone 6mg OD
£60.97
Olanzapine 20mg orodispersible OD
£60.71
Quetiapine 225mg (200mg+25mg) BD
£56.91
Quetiapine 150mg BD
£32.52
Olanzapine 5mg orodispersible OD
£31.98
Olanzapine 20mg OD
£25.48
Olanzapine 5mg OD
£15.21
Risperidone 4mg OD
£15.05
Doses given do not imply therapeutic equivalence
N.B.: Asenapine is only intended
for use in acute crisis and not
licensed for maintenance therapy
£0
£500
£1,000
£1,500
£2,000
£2,500 £3,000
£3,500
copyright © RDTC 2015
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Cost comparison charts
4.2 Atypical antipsychotics – Low doses
April 2015: Atypical Antipsychotics – Low Doses - cost of 1 year's treatment
Risperidone 500microgram
(orodispersible) BD
£618.28
Risperidone 1mg (orodispersible) BD
£546.26
Sulpiride 200mg BD
£112.35
Amisulpride 50mg tablets BD
£41.86
Risperidone 500microgram BD
£38.95
Risperidone 1mg BD
£37.49
Quetiapine 25mg BD
£17.47
Haloperidol 500micrograms
£14.32
Olanzapine 2.5mg tablets
£13.26
£8.74
Quetiapine 25mg OD
£0
Doses given do not imply therapeutic equivalence
£100
£200
£300
£400
£500
£600
£700
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Cost comparison charts
4.3 Antidepressant drugs
April 2015: Antidepressant drugs - cost of 1 year's treatment
Trimipramine (75 mg)
£1,417.26
Nortriptyline (75 mg)
£1,275.89
Agomelatine (25mg)
£390.00
Duloxetine (60 mg)
£360.36
Phenelzine (60 mg)
£327.60
Venlafaxine (75 mg MR)
£287.04
Trazodone (150 mg)
£260.65
Mianserin (30 mg)
£238.42
Reboxetine (8 mg)
£229.44
Fluvoxamine (100 mg)
£206.39
Moclobemide (300 mg)
£169.75
Lofepramine (140 mg)
£79.82
Clomipramine (75 mg)
£71.37
Imipramine (75 mg)
£52.65
Amitriptyline (75 mg)
£42.90
Flupentixol (1 mg)
£29.48
Paroxetine (20 mg)
£27.79
Dosulepin (75 mg)
£23.40
Mirtazapine (30 mg)
£20.80
Escitalopram (10mg)
£19.89
Sertraline (50 mg)
£18.98
Venlafaxine (75 mg)
£17.29
Citalopram (20 mg)
£14.17
Fluoxetine (20 mg)
£14.07
£0
£200
Doses given do not imply therapeutic equivalence
£400
£600
£800
£1,000
£1,200
£1,400
£1,600
copyright © RDTC 2015
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Cost comparison charts
4.5 Drugs used in the treatment of obesity
April 2015: Drugs used in the treatment of obesity - cost of 1 year's treatment
Orlistat (120 mg TDS)
£344.63
£0
£50
£100
£150
£200
£250
£300
Doses given do not imply therapeutic equivalence
£350
£400
copyright © RDTC 2015
Contents
4.6 Drugs used in nausea and vertigo
April 2015: Drugs used in nausea and vertigo - cost of 1 year's treatment
Prochlorperazine buccal tablets (3 mg
BD)
£265.28
Hyoscine patch (Scopoderm TTS®,
once every 3 days)
£208.83
Hyoscine (20 mg TDS)
£117.00
Promethazine (Avomine®, 25 mg BD)
£81.38
Cyclizine (50 mg BD)
£79.86
Cinnarizine (15 mg TDS)
£77.87
Domperidone (10 mg TDS)
£63.66
Promethazine (Phenergan® 25 mg BD)
£60.45
Prochlorperazine (5 mg TDS)
£40.56
Metoclopramide (10 mg TDS)
£37.83
Betahistine (16 mg BD)
£17.33
£0
Doses given do not imply therapeutic equivalence
£50
£100
£150
£200
£250
£300
copyright © RDTC 2015
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Cost comparison charts
4.7 Analgesics
April 2015: Analgesics - cost of 7 days treatment
Tramacet® effervescent
(8 tablets)
£9.03
Aspirin 300 mg (12
tablets)
£8.79
Tramacet® (8 tablets)
£8.61
Nefopam 30 mg (9
tablets)
£7.41
Tramadol MR 400 mg (1
tablet)
£7.13
Buprenorphine 400
micrograms (4 tablets)
£5.64
Remedeine® (8 tablets)
£5.57
Co-codamol effervescent
30/500 (8 tablets)
£4.90
Co-codamol effervescent
8/500 (8 tablets)
£4.41
Co-codamol 30/500 (8
tablets)
£3.25
Codeine 30 mg (8 tablets)
£3.04
DHC Continus® 120 mg
(2 tablets)
£2.74
Dihydrocodeine 30 mg (8
tablets)
£2.70
Co-codamol 30/500 (8
capsules)
£2.30
Tramadol 50 mg (8
capsules)
£2.24
Co-codamol 8/500 (8
tablets)
£2.22
Co-dydramol 10/500 (8
tablets)
£2.18
Paracetamol 500 mg (8
tablets)
£0
£1
Doses given do not imply therapeutic equivalence
£1.68
£2
£3
£4
£5
£6
£7
£8
£9
£10
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Cost comparison charts
4.7.2 Opioid analgesics
April 2015: Opioid analgesics - cost of 7 days treatment
Diconal® (4 tablets)
£101.74
Pethidine 50 mg (8 tablets)
£56.92
Pentazocine 25 mg tablets (8 daily)
£48.30
Oxycodone 20mg / Naloxone 10mg MR tablets (4
daily)
£42.31
Oxycodone 40 mg MR tablets (2 daily)
£25.05
Oxycodone 20 mg capsules (4 daily)
£22.86
Pentazocine 50 mg capsules (4 daily)
£22.04
Tapentadol 150 mg MR tablets (2 daily)
£18.68
Tapentadol 75 mg tablets (4 daily)
£18.68
Hydromorphone 2.6 mg capsules (8 daily)
£17.64
Fentanyl transdermal patch (50 mcg per hour, 1
every 3 days)
£15.69
Hydromorphone 8 mg MR capsules (2 daily)
£14.02
Meptazinol 200 mg (8 tablets)
£11.06
Buprenorphine transdermal patch (10 mcg per hour,
1 per week)
£7.89
Tramadol MR 400 mg (1 tablet)
£7.13
Morphine 20 mg (5 tablets)
£6.63
Morphine 10 mg / 5 ml oral solution (50 ml daily)
£6.62
Morphine MR tablets (60 mg BD)
£5.67
Buprenorphine 400 mcg sublingual (4 tablets)
£5.64
Morphine MR capsules (60 mg BD)
£3.78
£0
Doses given do not imply therapeutic equivalence
£20
£40
£60
£80
£100
£120
copyright © RDTC 2015
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Regional Drug and Therapeutics Centre
Cost comparison charts
4.7.2 MR Opioid analgesics
April 2015: MR opioid analgesics - cost of 7 days treatment
OxyContin 40mg modified-release tablets (1 BD)
£25.05
Oxylan 40mg modified-release tablets (1 BD)
£25.00
Candox 40mg modified-release tablets (1 BD)
£20.00
Longtec 40mg modified-release tablets (1 BD)
£17.50
Reltebon 40mg modified-release tablets (1 BD)
£17.50
Carexil 20mg modified-release tablets (1 BD)
£13.22
OxyContin 20mg modified-release tablets (1 BD)
£12.52
Oxylan 20mg modified-release tablets (1 BD)
£12.50
Candox 20mg modified-release tablets (1 BD)
£10.00
Longtec 20mg modified-release tablets (1 BD)
£8.75
Reltebon 20mg modified-release tablets (1 BD)
£8.75
MXL 120mg capsules (1 OD)
£7.29
MST Continus 60mg tablets (1 BD)
£5.67
Morphgesic SR 60mg tablets (1 BD)
£4.21
Zomorph 60mg modified-release capsules (1 BD)
£3.78
Filnarine SR 60mg tablets (1 BD)
£3.59
MXL 60mg capsules (1 OD)
£3.74
MST Continus 30mg tablets (1 BD)
£2.91
Morphgesic SR 30mg tablets (1 BD)
£2.16
Zomorph 30mg modified-release capsules (1 BD)
£1.94
Filnarine SR 30mg tablets (1 BD)
£1.84
£0
Doses given do not imply therapeutic equivalence
£5
Several NHS bodies recommend
that modified-release forms of
strong opioids be prescribed by
brand name to avoid confusion and
reduce risk of harm.
£10
£15
£20
£25
£30
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Cost comparison charts
4.7.2 Strong opioid analgesics – equipotent dose cost per 24 hours
April 2015: Costs per 24 hours for strong opioids administered via subcutaneous infusion
Oxycodone 100mg/24hours
£28.04
Morphine sulphate 150mg/24hours
£27.10
Diamorphine 100mg/24hours
£8.48
Oxycodone 30mg/24hours
£4.80
Diamorphine 30mg/24hours
Please Note: Doses shown are only approximately equivalent and for
price comparison purposes only. Extreme caution is required when
converting from one parenteral opioid to another and specialist
advice should always be sought.
£2.80
Morphine 45mg/24hours
£1.78
Diamorphine 15mg/24hours
There are differences in opinion regarding dose conversion ratios —
current practice is based on pharmacokinetic data from
observational and uncontrolled studies, and on expert opinion and
experience. Reported equi-analgesic dose ratios vary widely. When
converting from one opioid to another, regular assessment and
reassessment of efficacy and adverse effects is essential because of
the lack of evidence on equi-analgesic doses and inter-individual
variations.
£5.27
Oxycodone 15mg/24hours
£3.20
Morphine 30mg/24hours
£2.65
Diamorphine 10mg/24hours
£3.00
Oxycodone 10mg/24hours
£1.60
Morphine 15mg/24hours
£0.90
Diamorphine 5mg/24hours
£2.27
Morphine 10mg/24hours
£0.94
Oxycodone 5mg/24hours
£0.80
£0
£5
£10
£15
£20
£25
£30
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Regional Drug and Therapeutics Centre
Cost comparison charts
4.7.3 Neuropathic pain
April 2015: Neuropathic pain - cost of 1 year's treatment
Pregabalin (100mg TDS)
£1,255.80
Lidocaine patch (1/day)
£878.45
Pregabalin (150mg BD)
£837.20
Nortriptyline (25mg OD)
£425.30
£360.36
Duloxetine (60mg OD)
Carbamazepine (200mg QDS)
£265.72
Capsaicin 0.075% cream (1.5g/day)
£176.90
Gabapentin (600mg TDS)
£111.06
Gabapentin (2x300mg TDS)
£101.77
£14.30
Amitriptyline (25mg OD)
£0
£200
£400
£600
£800
£1,000
£1,200
£1,400
copyright © RDTC 2015
Doses given do not imply therapeutic equivalence. Individual responses and prescribed doses vary substantially in the management of neuropathic pain
Contents
4.7.4.1 Antimigraine drugs (acute)
April 2015: Antimigraine drugs (acute) - cost of 1 days treatment
Sumatriptan injection (6 mg)
£21.24
Sumatriptan (Imigran Radis® 100 mg)
£7.15
Sumatriptan nasal spray (20 mg)
£7.08
Rizatriptan wafers (10 mg)
£4.46
Eletriptan (20 or 40 mg)
£3.75
Almotriptan (12.5 mg)
£3.02
Frovatriptan (2.5 mg)
£2.78
Migril® (4 tablets)
£2.04
Rizatriptan tablets (10 mg)
£1.35
Tolfenamic acid (200 mg)
£1.28
Naratriptan (2.5 mg)
£0.37
Sumatriptan tablets (100 mg)
£0.31
Sumatriptan tablets (50mg)
£0.29
Zolmitriptan (2.5 mg)
£0.20
£0
Doses given do not imply therapeutic equivalence
£5
£10
£15
£20
£25
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Cost comparison charts
4.8 Antiepileptic drugs
April 2015: Antiepileptic drugs - cost of 1 year's treatment
£1,820.00
Perampanel 2mg tablets (OD)
£1,686.62
Lacosamide 150mg (BD)
£1,650.13
Eslicarbazepine 800mg
Zonisamide 100mg capsules (QDS)
£1,630.72
Ethosuximide 250mg capsules (QDS)
£1,253.20
Pregabalin 150mg capsules (BD)
£837.20
Levetiracetam (Desitrend®) 750mg sachets (BD)
£750.69
Phenytoin sodium 100mg capsules (TD)
£702.00
£598.56
Primidone 250mg tablets (BD)
£538.87
Vigabatrin 500mg tablets (QDS)
£440.00
Oxcarbazepine 450mg tablets
Epilim Chrono tablets (1200mg daily)
£254.25
Episenta MR capsules (1200mg daily)
£189.28
Topiramate 200mg tablets (BD)
£188.67
Epival CR tablets (1200mg daily)
£176.61
£98.06
Sodium valproate 200mg gastro-resistant tablets
Levetiracetam 750mg tablets (BD)
£83.48
Clobazam 10mg tablets (BD)
£72.56
Levetiracetam (Desitrend®) 750mg sachets (BD) = Levetiracetam (Desitrend®) 500mg sachets (BD) +
Levetiracetam (Desitrend®) 250mg sachets (BD)
Carbamazepine 400mg MR tablets (BD)
£65.26
Clonazepam 2mg tablets (BD)
£63.41
Oxcarbazepine 450mg tablets = Oxcarbazepine 300mg tablets (BD) + Oxcarbazepine 150mg (BD) tablets
£55.91
Modified-release sodium valproate:
Epilim Chrono tablets 1200mg daily = Epilim Chrono 500mg tablets (BD) + Epilim Chrono 200mg tablet (OD)
Episenta MR capsules 1200mg daily = 2 x Episenta 300mg MR capsules BD
Epival CR tablets 1200mg daily = 2 x Epival 300mg CR tablets BD
Gabapentin 400mg capsules (TD)
Phenobarbital 30mg tablets (TD)
£37.83
Lamotrigine 100mg tablets (BD)
£30.68
£0
Doses given do not imply therapeutic equivalence
£200
£400
£600
£800
£1,000
£1,200
£1,400
£1,600
£1,800
£2,000
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Cost comparison charts
4.10.2 Nicotine dependence
April 2015: Nicotine dependence - cost of 7 days treatment
Nicotine 2 mg sublingual tablets (40)
£36.74
Nicorette QuickMist® (single pack) 1mg/spray (64
sprays)
£36.20
Nicorette® nasal spray (64 sprays)
£30.91
Nicorette QuickMist® (double pack) 1mg/spray (64
sprays)
£28.58
Nicotinell® lozenge 1 mg (25 lozenges)
£16.63
Nicotinell® chewing gum 2 mg (25 pieces)
£15.06
Niquitin® lozenges 2 or 4 mg (15 lozenges)
£14.54
Niquitin® gum 2 or 4 mg (15 pieces)
£14.54
Varenicline 1 mg (BD)
£13.65
Nicotinell® chewing gum 4 mg (15 pieces)
£11.22
Nicorette® chewing gum 4 mg (15 pieces)
£11.22
Nicorette® patches 5, 10, or 15 mg (1 patch)
£10.37
Niquitin® 7, 14, or 21 mg (1 patch)
£9.97
Nicotinell TTS 30® (1 patch)
£9.97
Bupropion 150 mg MR (BD)
£9.74
Nicotinell TTS 20® (1 patch)
£9.40
Nicotinell TTS® 10 (1 patch)
£9.12
Nicorette® chewing gum 2 mg (15 pieces)
£9.03
£0
Doses given do not imply therapeutic equivalence
£5
£10
£15
£20
£25
£30
£35
£40
copyright © RDTC 2015
Contents
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Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
4.11 Drugs for dementia
April 2015: Drugs for dementia - cost of 1 year's treatment
Galantamine 24mg MR capsules
£1,037.40
£963.30
Galantamine 12mg tablets
Rivastigmine 4.6mg/24 hours patches
£946.04
Memantine hydrochloride 5 mg/actuation oral solution
£897.04
£843.70
Galantamine 16mg MR capsules
Galantamine 8mg tablets
£790.92
Gatalin XL® 24mg capsules
£518.70
Gatalin XL® 16mg capsules
£421.85
Rivastigmine 6mg capsules
£415.48
£384.51
Rivastigmine 9.5mg/24 hours patches
Donepezil 10mg orodispersible tablets
£103.09
Donepezil 5mg orodispersible tablets
£88.40
Rivastigmine 3mg capsules
£85.02
Memantine 20mg tablets
£34.19
Donepezil 10mg tablets
£21.45
Donepezil 5mg tablets
£17.03
Doses given do not imply therapeutic equivalence
£0
£200
£400
£600
£800
£1,000
Contents
30
£1,200
copyright © RDTC 2015
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
5 Miscellaneous antimicrobial and anthelmintic drugs
April 2015: Miscellaneous antimicrobial and anthelmintic drugs - cost of 5 days treatment
Nitrofurantoin MR (200 mg)
£6.79
Nitrofurantoin tablets (200 mg)
£4.30
Nitrofurantoin capsules (200 mg)
£3.47
Co-trimoxazole 480 mg (4)
£2.39
Azithromycin (500 mg, three doses
only)
£1.77
Erythromycin (1g)
£1.34
Metronidazole tablets (1.2 g)
£1.21
Clarithromycin (250 mg BD)
£1.16
Trimethoprim (400 mg)
£0.94
Mebendazole (100 mg, single-dose
only)
£0.23
£0
£1
£2
£3
£4
£5
£6
£7
Doses given do not imply therapeutic equivalence
£8
copyright © RDTC 2015
5.1.1 Penicillins
April 2015: Penicillins - cost of 5 days treatment
Ampicillin (1 g)
£7.63
Floxapen® (1 g)
£4.58
Magnapen® (4 capsules)
£4.00
Augmentin 375® (3 tablets)
£3.59
£3.48
Co-amoxiclav 250/125 (3 tablets)
Co-fluampicil 250/250 (4 capsules)
£2.55
Amoxil® (750 mg)
£2.41
Amoxicillin (750 mg)
£0.98
Flucloxacillin (1 g)
£0.93
Phenoxymethylpenicillin / Penicillin V (1
g)
£0.86
£0
Doses given do not imply therapeutic equivalence
£1
£2
£3
£4
£5
£6
£7
£8
£9
copyright © RDTC 2015
Contents
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Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
5.1.2 Cephalosporins
April 2015: Cephalosporins - cost of 5 days treatment
Cefuroxime (250 mg BD)
£12.64
Cefadroxil (500 mg BD)
£11.17
£9.45
Cefixime (200 mg)
£6.50
Cefaclor MR (375 mg BD)
Cefaclor (250 mg TDS)
£4.86
Cefradine (500 mg BD)
£1.71
£1.13
Cefalexin tablets (500 mg BD)
£0.81
Cefalexin capsules (500 mg BD)
£0
£2
£4
£6
£8
£10
Doses given do not imply therapeutic equivalence
£12
£14
copyright © RDTC 2015
5.1.3 Tetracyclines
April 2015: Tetracyclines - cost of 5 days treatment
Demeclocycline (600 mg)
£58.21
Lymecycline (816 mg)
£3.41
*Minocycline tablets (100 mg)
£2.49
*Minocycline capsules (100 mg)
£2.34
*Minocycline MR (100 mg)
£1.79
*Tetracycline (1 g)
£1.74
*Lymecycline (408 mg)
£1.71
*Oxytetracycline (1 g)
£0.86
*Doxycycline (100 mg)
£0.71
*courses for acne w ill be
longer than 5 days
£0
Doses given do not imply therapeutic equivalence
£10
£20
£30
£40
£50
£60
£70
copyright © RDTC 2015
Contents
32
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
5.1.12 Quinolones
April 2015: Quinolones - cost of 5 days treatment
£21.64
Ofloxacin (800 mg)
£11.53
Moxifloxacin (400 mg)
Levofloxacin (500 mg)
£7.90
Ciprofloxacin (500 mg BD)
£1.09
Ciprofloxacin (250 mg BD)
£0.93
£0
£5
£10
£15
£20
Doses given do not imply therapeutic equivalence
£25
copyright © RDTC 2015
5.2 Miscellaneous antifungal drugs (including topical and gynaecological)
April 2015: Miscellaneous antifungal drugs (including topical and gynaecological) - cost of 28 days
treatment unless otherwise stated
Itraconazole (200 mg OD, 7 days)
£4.27
Clotrimazole pessary (500 mg x 1)
£3.47
Terbinafine (250 mg OD, 28 days)
£3.28
Ketoconazole 2% shampoo (120 ml)
£3.27
Miconazole oral gel (15 g, 1 tube)
£3.23
Miconazole pessaries (100 mg x 14)
£3.00
Miconazole vaginal capsule (1.2 g x 1)
£2.94
Miconazole 2% cream (30 g, 1 tube)
£1.82
Nystatin suspension (1 ml, QDS, 1 week)
£1.56
Clotrimazole 1% cream (20 g, 1 tube)
£1.36
£1.22
Itraconazole (200 mg BD, 1 day)
Fluconazole (150 mg, single-dose)
£1.03
Fluconazole (50 mg OD for 2 weeks)
£1.02
Doses given do not imply therapeutic equivalence
£0
£1
£1
£2
£2
£3
£3
£4
£4
£5
copyright © RDTC 2015
Contents
33
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
6.1.1 Insulins (prefilled pens and cartridges)
April 2015: Insulins (prefilled pens) - cost of 1 year's treatment
Xultophy® (40 units)
£1,545.50
Humalog® Mix 25 Kw ikPen (40 units)
£300.71
Humalog® Mix 50 Kw ikPen (40 units)
£300.71
NovoMix® 30 FlexPen (40 units)
Humulin M3® Kw ikPen (40 units)
Insuman® Comb 25 SoloStar (40 units)
Mixed Insulins
£290.13
£210.63
£192.19
Tresiba® FlexTouch (40 units)
£698.88
Levemir® FlexPen (40 units)
£407.68
Lantus® SoloStar (40 units)
£402.83
Humulin I® Kw ikPen (40 units)
£210.63
Insulatard® InnoLet (40 units)
£198.02
Insuman® Basal SoloStar (40 units)
£192.19
NovoRapid® FlexPen (40 units)
£297.02
Humalog® Kw ikPen (40 units)
£285.96
Apidra® SoloStar (40 units)
£0
Doses given do not imply therapeutic equivalence
Long-acting insulin+GLP-1 combination
Intermediate and long acting insulins
Short acting insulins
£274.70
£200
£400
£600
£800
£1,000
£1,200
£1,400
£1,600
£1,800
copyright © RDTC 2015
Contents
April 2015: Insulins (cartridges) - cost of 1 year's treatment
Mi
Humalog® Mix 50 (40 units)
£285.96
Humalog® Mix25 (40 units)
£285.96
NovoMix® 30 (40 units)
£279.45
Humulin M3® (40 units)
Mixed Insulins
£185.20
Insuman® Comb 25 (40 units)
£169.87
Insuman® Comb 50 (40 units)
£169.87
Tresiba® (40 units)
£698.88
Levemir® (40 units)
£407.68
Lantus® (40 units)
£402.83
Insulatard® (40 units)
Intermediate and long acting insulins
£222.28
Humulin I® (40 units)
£185.20
Insuman® Basal (40 units)
£169.87
Humalog® (40 units)
£274.80
NovoRapid® (40 units)
£274.80
Apidra® (40 units)
£274.70
Insuman Rapid® (40 units)
Short acting insulins
£169.87
Humulin S® (40 units)
£154.34
£0
Doses given do not imply therapeutic equivalence
£100
£200
£300
£400
£500
£600
£700
£800
copyright © RDTC 2015
Contents
34
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
Needles For Pre-Filled And Reusable Insulin Pens
N
April 2015: Needles for Pre-filled and Reusable Insulin Pens - cost
of 100 needles
Registered trade names ®
£30.08
B D A uto Shield Duo 5mm/30G
No vo Fine 6mm/31G
£13.02
No vo Twist 5mm/32G
£12.99
£12.84
M ylife Clickfine 6mm/31G
Unifine P entips 5mm/31G
Unifine P entips 4mm/32G & 6mm/31G
Co mfo rt P o int 4mm/31G, 5mm/31G & 6mm/31G
B D M icro-Fine Ultra 4mm/32G & B D M icro-Fine+ 5mm/31G
Unifine P entips P lus 5mm/31G & 6mm/31G
Insupen 5mm/31G & 6mm/31G
NeedleB ay Fine 4mm/32G & 5mm/31G
£12.32
4 to 6 mm Pen Needles
M ylife Clickfine 4mm/32G
£12.00
£11.75
£9.95
£9.69
£8.69
£7.11
£6.95
TriCare 4mm/32G & 5mm/31G
£5.95
M icro do t Dro plet & Omnican Fine 4mm & 6mm
£5.95
Gluco Rx FineP o int 4mm/31G, Ultra 4mm/32G, 5mm/31G & 6mm/31G
£5.95
M ylife P enfine Classic 4mm/32G & 6mm/32G
£5.94
No vo Fine A uto co ver 8mm/30G
£22.28
M ylife Clickfine A uto P ro tect 8mm/29G
£19.00
No vo Fine 8mm/30G
£9.24
M ylife Clickfine 8mm/31G
£9.11
£8.25
B D M icro-Fine+ 8mm/31G
Insupen 8mm/31G
NeedleB ay Fine 8mm/31G
Co mfo rt P o int 8mm/31G
TriCare 6mm/31G & 8mm/31G
8 mm Pen Needles
Unifine P entips 8mm/31G
Unifine P entips P lus 8mm/31G
£7.90
£7.90
£7.11
£6.95
£6.60
£5.95
M icro do t Dro plet 8mm/31G
£5.95
Omnican Fine 8mm/31G
£5.95
Gluco Rx FineP o int 8mm/31G
£5.95
M ylife P enfine Classic 8mm/31G
£5.94
No vo Fine 12mm/28G
Unifine P entips 12mm/29G
Insupen 12mm/29G
Co mfo rt P o int 12mm/29G
Gluco Rx FineP o int 10mm/29G & 12mm/29G
Omnican Fine 10mm/30G & 12mm/29G
£9.40
12 mm Pen Needles
M ylife Clickfine 10mm/29G & 12mm/29G
£0
Needles may not be interchangeable - consult product literature
£9.11
£8.25
£7.11
£6.60
£5.95
£5.95
£5
£10
£15
£20
£25
£30
£35
copyright © RDTC 2015
Contents
35
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
Blood lancets
April 2015: Blood lancets - cost of 100 lancets
Registered trade names ®
Unistik 3 Comfort lancets
1.8mm/28gauge
£6.17
FastClix lancets
0.3mm/30gauge
£4.82
Multiclix lancets
0.3mm/30gauge
£4.80
Softclix lancets
0.4mm/28gauge
£3.91
OneTouch Comfort lancets
0.2mm/33gauge
£3.82
OneTouch UltraSoft lancets
0.4mm/28gauge
£3.81
Thin lancets 0.36mm/28gauge
£3.78
Microlet lancets
0.5mm/28gauge
£3.72
FreeStyle lancets
0.5mm/28gauge
£3.67
TRUEplus lancets
0.32mm/30gauge
£2.90
Milw ard Steri-Let Lancets
0.66mm/23gauge
£2.85
Vitrex Soft lancets
0.65mm/23gauge
£2.85
Unilet Eco lancets
0.375mm/28gauge
£2.80
Mylife lancets multicolour
0.3mm/30gauge
£2.75
Mylife lancets 0.3mm/30gauge
£2.75
GlucoRx lancets
0.31mm/30gauge
£2.75
Omnican Lance Soft
0.3mm/30gauge
£2.73
Apollo tw ist lancets
0.36mm/28gauge
£2.25
iCare Advanced lancets
0.38mm/30gauge
£2.23
£0
£1
£2
£3
£4
£5
£6
£7
copyright © RDTC 2015
Contents
36
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
6.1.6 Blood glucose monitoring
April 2015: Blood glucose monitoring - cost of 50 tests
Registered trade names ®
Compact
£16.15
Mobile
£16.09
FreeStyle Lite
£15.73
Aviva
£15.72
FreeStyle Optium
£15.64
Contour
£15.23
OneTouch Vita
£15.07
Contour Next
£15.04
iCare Advanced Solo
£13.50
OneTouch Ultra
iCare Advanced Solo testing
strips has extended life span,
see manufacturer guidelines
£11.99
Active
£9.95
GlucoRx Nexus
£9.95
TRUEyou
£9.92
Omnitest 3
£9.89
GluNEO
£9.89
Element
£9.89
GlucoLab
£9.89
WaveSense JAZZ
£9.87
iCare Advanced
£9.70
Contour TS
£9.50
Mylife Pura
£9.50
Mylife Unio
£9.50
GlucoRx Original
£9.45
SuperCheck Plus
£9.45
AutoSense
£9.00
SuperCheck 2
AutoSense testing strips
supplied in packs of 25 costing
£4.50
£8.49
TEE2
£7.75
SD Codefree
Glucoflex-R
Mobile test cassettes
supplied in packs of 100
costing £32.18
£6.99
Visually
readable
£6.75
£0
£6
£12
Test strips are not usually interchangeable - consult manufacturers' literature
The test strips included in the chart are
a mixture of the most commonly
prescribed in the North of England, the
least costly and those w ith extended
shelf-lives.
£18
£24
copyright © RDTC 2015
Contents
37
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
6.1.2 Antidiabetic drugs
April 2015: Antidiabetic drugs - cost of 1 year's treatment
Liraglutide (1.8mg OD)
DOSE NOT RECOMMENDED BY NICE
£1,182.35
Dulaglutide (0.75mg or 1.5mg per week)
Exenatide (2mg vial per week)
£953.68
Liraglutide (1.2mg OD)
£951.27
Exenatide (5 or 10 mcg BD)
£827.98
Tolbutamide (1.5 g/day)
£799.50
Lixisenatide (20 mcg OD)
£656.90
Empagliflozin (10mg OD)
£475.67
Dapagliflozin (10 mg OD)
£475.67
Dapagliflozin (5mg) / metformin (850mg BD)
£475.67
Canagliflozin (50mg) / metformin (850mg BD)
£475.63
Canagliflozin (100mg OD)
£475.63
Pioglitazone (15mg) / metformin (850 mg BD)
£466.57
Sitagliptin (100 mg OD)
£432.38
Linagliptin (2.5mg) / metformin (850mg BD)
£432.38
£432.38
Linagliptin (5 mg OD)
Metformin 1g / sitagliptin 50mg (BD)
£432.38
Vildagliptin (50 mg BD)
£412.88
Vildagliptin (50mg)/ metformin (850mg BD)
£412.29
Saxagliptin (2.5mg) / metformin (850mg BD)
£410.80
Saxagliptin (5mg OD)
£410.80
Alogliptin (12.5mg) / metformin (1g BD)
£345.80
Alogliptin (25mg, 12.5mg, 6.25mg OD)
£345.80
Nateglinide (180 mg/day)
£336.44
Acarbose (150 mg/day)
£117.09
Metformin 500 mg MR (3/day)
£103.74
Glipizide (10 mg/day)
£83.98
Metformin (1.5 g/day)
£57.33
Repaglinide (4 mg)
£47.40
Gliclazide (160 mg/day)
£31.72
Pioglitazone (30 mg OD)
£18.98
Pioglitazone (15 mg OD)
£15.99
Glimepiride (2 mg OD)
£14.92
Doses given do not imply therapeutic equivalence
£1,428.34
£0
£200
Needles are included in packs of longacting exenatide (2mg vial per w eek) at no
extra cost. The cost of needles for other
GLP-1 agonists w ill vary betw een £22 pa
and £95 pa, depending on dose frequency
and needle choice.
£400
£600
£800
£1,000 £1,200 £1,400 £1,600
copyright © RDTC 2015
Contents
38
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
6.1.2 Antidiabetic drugs – Newer agents
April 2015: Antidiabetic drugs - Newer agents - cost of 1 year's treatment
Liraglutide (1.8mg OD)
£1,182.35
Exenatide (2mg vial per week)
£953.68
Liraglutide (1.2mg OD)
£951.27
Exenatide (5 or 10 mcg BD)
£827.98
Lixisenatide (20 mcg OD)
£656.90
Canagliflozin (300mg OD)
£606.55
Empagliflozin (10mg or 25mg OD)
£475.67
Dapagliflozin (5mg or 10 mg OD)
£475.67
Dapagliflozin (5mg) / metformin (850mg BD)
£475.67
Canagliflozin (50mg) / metformin (850mg BD)
£475.63
Canagliflozin (100mg OD)
£475.63
Sitagliptin (100 mg OD)
£432.38
Linagliptin (2.5mg) / metformin (850mg BD)
£432.38
Linagliptin (5 mg OD)
£432.38
Metformin 1g / sitagliptin 50mg (BD)
£432.38
Vildagliptin (50 mg BD)
£412.88
Vildagliptin (50mg)/ metformin (850mg BD)
£412.29
Saxagliptin (2.5mg) / metformin (850mg BD)
£410.80
Saxagliptin (5mg OD)
£410.80
Alogliptin (12.5mg) / metformin (1g BD)
Needles are included in packs of long-acting
exenatide (2mg vial per week) at no extra cost.
The cost of needles for other GLP-1 agonists will
vary between £22 pa and £95 pa, depending on
dose frequency and needle choice.
£345.80
Alogliptin (25mg, 12.5mg, 6.25mg OD)
Doses given do not imply therapeutic equivalence
£1,428.34
DOSE NOT RECOMMENDED BY NICE
Dulaglutide (0.75mg or 1.5mg per week)
£345.80
£0
£200
£400
£600
£800
£1,000
£1,200
£1,400
£1,600
copyright © RDTC 2015
6.6.2 Bisphosphonates and other drugs affecting bone metabolism
April 2015: Bisphosphonates and other drugs affecting bone metabolism - cost of 1 year's treatment
Denosumab (Prolia®)
£396.50
Strontium ranelate sachets (2 g)
£352.04
Risedronate sodium (5 mg)
£192.14
Ibandronic acid (150 mg monthly)
£21.84
Alendronic acid (10 mg)
£21.32
Risedronate sodium (35 mg weekly)
£16.51
Alendronic acid (70 mg weekly)
£13.39
£0
Doses given do not imply therapeutic equivalence
£50
£100
£150
£200
£250
£300
£350
£400
£450
copyright © RDTC 2015
Contents
39
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
7.3 Contraceptives – Combined hormonal contraceptives
April 2015: Contraceptives - Combined Hormonal Contraceptives cost of 1 year's treatment
Registered trade names ®
Cilest (21)
Lizinna (21)
Synphase (21)
TriNovum (21)
BiNovum (21)
Norimin (21)
Brevinor (21)
Ovysmen (21)
Elevin (21)
Cleosensa (21)
Yasmin (21)
Dretine (28)
Acondro (21)
Marvelon (21)
Femodene (21)
Alenvona (21)
Femodene ED (28)
Katya 30/75 (21)
Gedarel 30/150 (21)
Millinette 30/75 (21)
Lestramyl (21)
Cimizt (21)
Loestrin 30 (21)
Microgynon 30 ED (28)
Microgynon 30 (21)
Ovranette (21)
Rigevidon (21)
Levest (21)
Femodette (21)
Mercilon (21)
Sunya (21)
Millinette 20/75 (21)
Gedarel 20/150 (21)
Loestrin 20 (21)
Nuvaring (28)
Qlaira (28)
Zoely (28)
Evra (21)
Triadene (21)
Logynon (21)
Logynon ED (28)
TriRegol (21)
Norinyl-1 (21)
£31.03
£23.27
£15.60
£14.99
£10.79
£9.88
£8.62
£8.19
Ethinylestradiol 35 microgram
£126.75
£63.70
£63.70
£48.19
£36.18
£30.77
£29.16
£27.95
£23.08
£21.80
£18.16
£17.85
£16.47
£16.47
£14.39
£12.96
£12.22
£9.53
£8.19
£7.80
Ethinylestradiol 30 microgram
£38.35
£36.57
£28.69
£23.44
£22.01
Ethinylestradiol 20 microgram
£9.97
£128.70
£101.32
£85.80
£84.54
£45.07
£16.55
£13.00
£10.53
£9.49
£0
£20
Doses given do not imply therapeutic equivalence
Other contraceptives
£40
£60
£80
£100
£120
£140
copyright © RDTC 2015
Contents
40
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
7.3 Contraceptives – Progestogen-only contraceptives
April 2015: Contraceptives - Progestogen-only Contraceptives cost of 1 year's treatment
Registered trade names ®
£41.38
Cerazette (28)
£37.61
Desorex (28)
£22.58
Aizea (28)
£18.63
Cerelle (28)
Nacrez (28)
£15.17
Zelleta (28)
£14.95
Oral Progestogen-only
Contraceptives
Norgeston (28)
Noriday (28)
Micronor (28)
£9.57
£9.10
£7.80
Sayana Press (1 every 13
wks)
£29.90
Nexplanon (1 every 3 yrs)
£27.81
Noristerat (1 every 8 wks)
£26.32
Depo-Provera pfs (1 every
12 wks)
£26.04
Jaydess (1 every 3 yrs)
£23.07
Mirena (1 every 5yrs)
£0
£5
Doses given do not imply therapeutic equivalence
Parenteral and Intrauterine Progestogen-only
Contraceptives
£17.60
£10
£15
£20
£25
£30
£35
£40
£45
copyright © RDTC 2015
Contents
41
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
7.4.1 Drugs for urinary retention
April 2015: Drugs for urinary retention - cost of 1 year's treatment
Solifenacin 6mg / Tamsulosin 400microgram modified-release tablets
£335.12
Dutasteride 500microgram / Tamsulosin 400microgram capsules
£240.24
Dutasteride (500 micrograms)
£177.15
Alfuzosin MR (10 mg)
£151.79
Tamsulosin MR tablets (400 micrograms)
£127.04
Indoramin (40 mg)
£98.40
Prazosin (4 mg)
£83.96
Alfuzosin (7.5 mg)
£59.88
Tamsulosin MR capsules (400 micrograms)
£56.06
Terazosin (5 mg)
£36.40
Finasteride (5 mg)
£21.45
Doxazosin (4 mg)
£14.56
£0
Doses given do not imply therapeutic equivalence
£50
£100
£150
£200
£250
£300
£350
£400
copyright © RDTC 2015
Contents
42
Apr 2015
Regional Drug and Therapeutics Centre
Cost comparison charts
7.4.2 Drugs for urinary frequency, enuresis and incontinence
April 2015: Drugs for urinary frequency, enuresis and
incontinence - cost of 1 year's treatment
£480.48
Duloxetine (40 mg BD)
Solifenacin (10 mg)
£435.71
Oxybutynin patch (Kentera®)
£353.60
Mirabegron MR (Betmiga® 25mg/50mg OD)
£351.87
Propiverine (15 mg TDS)
£351.00
Propantheline 15 mg tablets (5)
£337.03
Tolterodine MR (4 mg)
£335.14
Fesoterodine MR (4 or 8 mg OD)
£335.14
Solifenacin (5 mg)
£335.12
Oxybutynin MR (10 mg)
£334.15
Darifenacin (7.5 or 15 mg OD)
£331.24
Propiverine MR (30mg)
£317.85
Trospium (20 mg BD)
£300.91
Trospium MR (Regurin® XL 60mg)
£299.65
Oxybutynin (3 mg BD)
£218.14
Trospium (Flotros® 20 mg BD)
£187.70
£167.08
Oxybutynin MR (5 mg)
Flavoxate (200 mg TDS)
£141.60
Tolterodine (2 mg BD)
£36.14
Oxybutynin (5 mg BD)
£31.20
Oxybutynin (2.5 mg BD)
Doses given do not imply therapeutic equivalence
£22.75
£0
£100
£200
£300
£400
£500
£600
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Cost comparison charts
7.4.5 Drugs for erectile dysfunction
April 2015: Drugs for erectile dysfunction - cost of 1 year's treatment
Tadalafil 5mg
£714.87
Alprostadil MUSE 250mcg
£575.85
Alprostadil 3mg/g (Vitaros®)
£509.60
Alprostadil (Caverject vials) 10microgram
£470.87
Alprostadil (Viridal duo) 10microgram
£421.69
Alprostadil (Caverject Dual Chamber) 10microgram
£374.56
Tadalafil 10mg
£343.85
Tadalafil 20mg
£343.85
Vardenafil 20mg
N.B.: Costs, other than for tadalafil
5mg, based on advice from DH
(circulated in HSC 1999/148) that one
treatment per week will be sufficient for
most patients treated for erectile
dysfunction.
Tadalafil 5mg cost assumes daily dose.
£299.14
Avanafil 200mg
£250.98
Vardenafil 10mg
£179.38
Avanafil 100mg
£167.28
Sildenafil 100mg
£15.67
Sildenafil 50mg
£14.65
£0
£100
£200
£300
£400
£500
£600
Doses given do not imply therapeutic equivalence
£700
£800
copyright © RDTC 2015
Contents
9.6.4 Calcium and vitamin D
April 2015: Calcium + vitamin D & vitamin D preparations - cost of 1 year's treatment
Calcium and ergocalciferol, 2 chewable tablets (194 mg calcium, 800 units
vitamin D)
£340.86
Cacit D3®, 2 sachets dissolved in water (1 g calcium, 880 units vitamin D)
£98.52
Calcichew D3®, 2 chewable tablets (1 g calcium, 400 units vitamin D)
£55.91
Calcichew D3®, 2 caplets swallowed whole or chewable (1 g calcium, 800 units
vitamin D)
£55.11
Calfovit D3®, 1 sachet dissolved in water (1.2 g calcium, 800 units vitamin D)
£52.42
Calcichew D3 Forte®, 2 chewable tablets (1 g calcium, 800 units vitamin D)
£51.45
Adcal D3®, 2 chewable tablets (1.2 g calcium, 800 units vitamin D)
£47.45
Adcal D3®, 4 caplets swallowed whole (1.2g calcium, 800 units vitamin D)
£47.45
Natecal D3®, 2 chewable tablets (1.2 g calcium, 800 units vitamin D)
£44.04
Fultium D3®, 1 capsule swallowed whole (800 units vitamin D)
£43.68
Desunin®, 1 tablets swallowed whole (800 units vitamin D)
£43.68
Calceos®, 2 chewable tablets (1 g calcium, 800 units vitamin D)
£43.44
Evacal®, 2 chewable tablets (1.2 g calcium, 800 units vitamin D)
£37.96
Accrete D3®, 2 tablets swallowed whole (1.2g calcium, 800 units vitamin D)
£35.79
InVita D3®, 1 ampoule every 6 weeks (25,000 units vitamin D)
£12.86
£0
Doses given do not imply therapeutic equivalence
£50
£100
£150
£200
£250
£300
£350
£400
copyright © RDTC 2015
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Cost comparison charts
10.1.1 Non-steroidal anti-inflammatory drugs
April 2015: Non-steroidal anti-inflammatory drugs - cost of 1 year's
treatment
Aspirin 300 mg tablets (12)
£457.28
Etoricoxib (90 mg)
£298.48
Acemetacin (60 mg BD)
£228.11
Tenoxicam (20 mg)
£210.08
Tiaprofenic acid MR (300 mg BD)
£194.35
Etodolac MR (600 mg)
£188.07
Ketoprofen (50 mg TDS)
£147.62
Mefenamic acid (500 mg)
£146.64
Aceclofenac (100 mg BD)
£116.84
Nabumetone (1 g)
£111.28
Flurbiprofen MR (200 mg)
£95.13
Naprosyn® / Naprosyn EC® (250 mg TDS)
£83.66
Naproxen EC (250 mg TDS)
£78.59
Piroxicam (20 mg)
£55.77
Naproxen (250 mg TDS)
£47.19
Ibuprofen (400 mg TDS)
£46.93
Celecoxib (200 mg)
£46.83
Indometacin (50 mg BD)
£42.12
Diclofenac sodium (50 mg TDS)
£36.27
Meloxicam (7.5 mg)
£14.07
£0
Doses given do not imply therapeutic equivalence
N.B. Patent protection on Celecoxib
expired November 2014.
Added to category M April 2015
£50
£100 £150
£200 £250 £300
£350 £400 £450 £500
copyright © RDTC 2015
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Regional Drug and Therapeutics Centre
Cost comparison charts
10.3.2 Rubefacients, topical NSAIDs, capsaicin, and poultices
April 2015: Rubefacients, topical NSAIDs, capsaicin, and poultices - cost of 1 year's treatment
Felbinac 3% gel (3 g)
£87.69
Benzydamine 3% cream (Difflam®, 3g)
£74.69
£73.52
Piroxicam 0.5% gel (3 g)
£63.23
Ibuprofen 10% gel (Ibugel Forte®, 3g)
Diclofenac 1% gel (3 g)
£61.48
Ibuprofen 5% gel (3 g)
£49.14
£48.27
Ketoprofen 2.5% gel (3 g)
Rubefacient (e.g. Transvasin® cream, 3
g)
Doses given do not imply therapeutic equivalence
£41.63
£0
£10
£20
£30
£40
£50
£60
£70
£80
£90
£100
copyright © RDTC 2015
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Cost comparison charts
11.6 Treatment of Glaucoma
April 2015: Treatment of Glaucoma - cost of 1 year's treatment
Dorzolamide 2% + timolol 0.5% (Cosopt®) PF
£371.67
£314.34
Dorzolamide 2% (Trusopt®) PF
Bimatoprost 0.03% (Lumigan®) PF
£178.75
Tafluprost (Saflutan®) PF
£158.60
Timolol 0.5% (Timoptol®) PF
£125.45
Latanoprost (Monopost®) PF
£110.37
Timolol 0.25% (Timoptol®) PF
£109.85
Timolol gel (Tiopex®) PF
Preservative free preparations
£97.37
Bimatoprost + timolol (Ganfort®)
£181.35
Travoprost + timolol (Duotrav®)
£181.35
Latanoprost (Xalatan®)
£162.24
£152.23
Bimatoprost 0.01% (Lumigan®)
Brinzolamide + timolol (Azarga®)
£143.65
Travoprost (Travatan®)
£142.35
Bimatoprost 0.03% (Lumigan®)
£133.90
Brimonidine + timolol (Combigan®)
£130.00
Brinzolamide 1% + Brimonidine 0.2% (Simbrinza®)
£119.99
Carteolol 2% (Teoptic®)
£109.20
£98.80
Carteolol 1% (Teoptic®)
Brinzolamide (Azopt®)
£89.96
Pilocarpine 4%
£56.55
Latanoprost + timolol
£50.44
Pilocarpine 2%
£47.19
Timolol 0.25% LA (Timoptol®-LA)
£40.56
Timolol 0.5% LA (Timoptol®-LA)
£40.56
Pilocarpine 1%
£37.31
Dorzolamide 2% + timolol 0.5%
£33.54
Dorzolamide 2%
£30.29
Brimonidine 0.2%
£30.16
Latanoprost (generic)
£28.08
Betaxolol 0.5% (Betoptic®)
£24.70
Levobunolol 0.5%
£24.05
Timolol 0.25%
£17.68
Timolol 0.5%
£17.29
Doses given do not imply therapeutic equivalence
£0
£50
£100
£150
£200
£250
£300
£350
£400
copyright © RDTC 2015
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Regional Drug and Therapeutics Centre
Cost comparison charts
11.8.1 Tear Deficiency, Ocular Lubricants, and Astringents
April 2015: Tear deficiency, ocular lubricants, and astringents - cost of 1 year's treatment
Sodium hyaluronate 0.15% PF
(Hyabak) 10ml
£87.89
Carmellose and glycerol (Optive) 10ml
£82.39
Carmellose, glycerol and castor-oil
(Optive Plus) 10ml
£82.39
Sodium hyaluronate 0.20% PF
(Hyloforte) 10ml
£76.00
Sodium hyaluronate 0.15% (Oxyal)
10ml
£58.10
Liquid paraffin (Lacrilube ointment) 5g
£54.32
Hypromellose 0.3% PF (Tear-Lac) 10ml
£46.00
Carbomer 980 0.2% (Geltears) 10g
£39.20
Hypromellose 0.3% (Generic) 10ml
Assumptions & Calculations
200 drops/applications per pack for non-metered-dose
products
1 drop/application per eye to both eyes TDS for 365 days
for drops. 1 application at night for ointments.
Rounded up to nearest full pack
£16.38
Polyvinyl alcohol (Sno Tears) 10ml
£13.78
Liquid paraffin + retinol (VitA-POS
ointment) 5g
£8.25
£0
Doses given do not imply therapeutic equivalence
£10
£20
£30
£40
£50
£60
£70
£80
£90
£100
copyright © RDTC 2015
c
Contents
12.2.1 Nasal steroids
April 2015: Nasal steroids - cost of 28 days treatment
Fluticasone 50 mcg/Azelastine 137
mcg (Dymista®) - 1 spray both nostrils
bd
£13.81
Fluticasone proprionate 50mcg
(Flixonase®) - 1 spray both nostrils od
£4.11
Triamcinolone 55 mcg (Nasacort®) - 1
spray both nostrils od
£3.45
Mometasone 50 mcg (Nasonex®) - 1
spray both nostrils od
£3.07
Fluticasone furoate 27.5 mcg
(Avamys®) - 1 spray both nostrils od
£3.01
Fluticasone proprionate 50mcg
(Nasofan®) - 1 spray both nostrils od
£3.00
Budesonide 64 mcg (Rhinocort aqua®) 1 spray both nostrils od
£1.63
Beclometasone 50 mcg (200 dose) - 1
spray both nostrils bd
£1.29
£0
Doses given do not imply therapeutic equivalence
£2
£4
£6
£8
£10
£12
£14
£16
copyright © RDTC 2015
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Cost comparison charts
13.2.1 Emollients (by volume)
April 2015: Emollients by volume - cost of 1 year's treatment
Calmurid® (500g)
£2,227.68
Balneum® plus (500g)
£1,558.96
E45® Itch relief (500g)
Aveeno® Cream (300ml)
£707.20
Yellow Soft Paraffin (500g)
£602.16
Aveeno® Lotion (500ml)
£415.58
Dermol® Cream (500g)
£413.71
Thirty:30® Ointment (500g)
£403.73
Diprobase® Cream (500g)
£394.37
Dermol® Lotion (500ml)
£376.90
Diprobase® Ointment (500g)
£373.78
Cetraben® (500g)
£373.78
Doublebase® Gel (500g)
£363.79
E45® Cream
£350.69
Zerobase® cream (500g)
£328.22
Aqueous Cream (500g)
£312.00
Oilatum® Cream (500ml)
£311.38
Hydrous Ointment (500g)
£305.14
Ultrabase® (500g)
£299.52
LP/WSP Ointment (50:50) (500g)
£285.17
E45® Lotion (500ml)
£280.80
ZeroCream® (500g)
Fifty:50® Ointment (500g)
£254.59
£228.38
ZeroAQS® emollient cream (500g)
£205.30
White Soft Paraffin (500g)
£201.55
Epimax® cream (500g)
£155.38
Emulsifying Ointment (500g)
£151.63
Oilatum® Junior cream (500ml)
Preparations containing urea
£935.38
Volumes can vary between
products. Usage is based on
600g/ml per adult and for Oliatum®
Junior cream 250ml per week.
£129.74
£0
Doses given do not imply therapeutic equivalence
£500
£1,000
£1,500
£2,000
£2,500
copyright © RDTC 2015
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Regional Drug and Therapeutics Centre
Cost comparison charts
13.2.1 Emollients per 100g/ml
April 2015: Emollients per 100g/ml
Calmurid® (500g)
£7.14
Balneum® plus (500g)
£5.00
E45® Itch relief (500g)
£3.00
Aveeno® Cream (300ml)
£2.27
Yellow Soft Paraffin (500g)
£1.93
Aveeno® Lotion (500ml)
£1.33
Dermol® Cream (500g)
£1.33
Thirty:30® Ointment (500g)
£1.29
Diprobase® Cream (500g)
£1.26
Dermol® Lotion (500ml)
£1.21
Diprobase® Ointment (500g)
£1.20
Cetraben® (500g)
£1.20
Doublebase® Gel (500g)
£1.17
E45® Cream
£1.12
Zerobase® cream (500g)
£1.05
Aqueous Cream (500g)
£1.00
Oilatum® Cream (500ml)
£1.00
Oilatum® Junior cream (500ml)
£1.00
Hydrous Ointment (500g)
£0.98
Ultrabase® (500g)
£0.96
LP/WSP Ointment (50:50) (500g)
£0.91
E45® Lotion (500ml)
£0.90
ZeroCream® (500g)
Fifty:50® Ointment (500g)
Preparations containing urea
£0.82
£0.73
ZeroAQS® emollient cream (500g)
£0.66
White Soft Paraffin (500g)
£0.65
Epimax® cream (500g)
£0.50
Emulsifying Ointment (500g)
£0.49
£0
£1
Doses given do not imply therapeutic equivalence
£2
£3
£4
£5
£6
£7
£8
copyright © RDTC 2015
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Cost comparison charts
13.2.1.1 Emollient bath and shower preparations per 100g/ml
April 2015: Emollient bath and shower preparations per 100g/ml
Oilatum® gel (150g)
£3.43
Oilatum® show er gel fragrance free (150g)
£3.43
£2.61
Doublebase® emollient show er gel (200g)
Aveeno® Bath Oil (250ml)
£1.80
Dermol® show er emollient (200ml)
£1.78
£1.70
Oilatum® Bath Formula (500ml)
£1.40
Oilatum® Plus bath additive (500ml)
£1.33
Balneum Plus bath oil (500ml)
E45 emollient w ash cream (250ml)
£1.28
Dermol® Bath Emollient (600ml)
£1.26
Dermol® Lotion (500ml)
£1.21
Emulsiderm emollient (1000ml)
£1.20
Doublebase® Gel (500g)
£1.17
Cetraben® emollient bath additive (500ml)
£1.15
Doublebase emollient bath additive (500ml)
£1.09
Balneum® Bath Oil (500ml)
£1.08
E45® emollient bath oil (500ml)
£1.02
Aqueous Cream (500g)
£1.00
Oilatum® Junior bath additive (600ml)
£0.98
Zerolatum® Emollient bath additive (500ml)
£0.96
Oilatum® Emollient (500ml)
£0.91
Hydromol® Bath & Show er emollient (500ml)
£0.88
LPL 63.4 (500ml)
£0
Doses given do not imply therapeutic equivalence
£0.62
£1
£2
£3
£4
copyright © RDTC 2015
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