Forskningsberetning for Gentofte Hospital 2014
Transcription
Forskningsberetning for Gentofte Hospital 2014
Forskningsberetning for Gentofte Hospital 2014 INDHOLD Forord 2 Forskningsråd Gentofte 3 Forskningsenheden 4 Forskerkarriereprogram på Gentofte Hospital 5 Forskningspuljer 2014 6 Forskningens Døgn 25. april 2014 7 Forskningens Dag 26. november 2014 8 Forskningstemaer, -personale og publikationer 2014 9 Anæstesi afd. 10 Ernæringsenheden i Serviceafdelingen 11 Forskningsenheden i HR & Kvalitet 12 Hjertemedicinsk afd. 13 Hud- og Allergiafd. 20 Klinisk Biokemisk afd. 26 Lungemedicinsk afd. 28 Medicinsk afd. C 30 Medicinsk afd. F 33 Ortopædkirurgisk afd. 37 Røntgen- og skannings afd. 39 1 Forord Pure rapport trukket juli 2015 Forskningsberetning 2014 for Gentofte Hospital kan atter dokumentere en stor og stigende forskningsaktivitet med en fremgang fra 2013 på knapt 12 % i antallet af publikationer, og kurven har været flot stigende fra 2010-2014 (stigning i alt på ca. 40 %, PURE udtræk juni 2015). Som det fremgår af denne beretning, har næsten alle afdelinger haft fremgang eller bibeholdt et meget højt niveau i perioden 2013-2014. Den regionale evaluering af kvaliteten af hospitalets forskning (målt på pointgivende forskningsaktiviteter som journal impact factors, fondsbevillinger, ph.d.-grader mm.) har ligeledes ligget meget tilfredsstillende i de foregående år. Den regionale forskningsevaluering for 2014 foreligger i efteråret 2015 I 2014 er Hospitalsdirektionens og Forskningsenhedens program for den strategiske forskningsporteføljeledelse fortsat. Indsatsområderne i Gentofte Hospitals Forskningsstrategi 2013-2018 blev fulgt op ved besøg på alle afdelinger i 2014, og handleplaner og anbefalinger for det videre arbejde med at lede og udvikle forskningsorganisationerne er fulgt op og udbygget. Der er fortsat stærk udvikling, aktivitet og international klasse i Gentofte Hospitals 3 Global Excellencemiljøer (Hjertemedicin, Hud- og Allergi samt Center for Diabetesforskning) og en særdeles lovende udvikling i en række andre forskergrupper. I 2011 bevilgede Gentofte Hospitals direktion 5 mio. kr. pr. år til oprettelse af et program for flerårige halvtids-forskerdelestillinger rettet mod fastansatte læger og MVU’ere på postdoc og seniorforskerniveau. Denne ordning har haft stor succes målt på det overvældende antal af meget højt kvalificerede ansøgere og på det øgede videnskabelige output, der efterhånden tegner sig hos forskerne i disse delestillinger. Forskerne har deltaget i udviklingssamtaler i årene 2013-2015, hvilket har givet mulighed for strategisk forskningsunderstøttende coaching og karrierevejledning i henhold til forskerens og hospitalets muligheder, visioner og forskningsstrategi. Samtalerne har blotlagt entusiasmen og de meget høje ambitionsniveauer hos forskerne. Delestillingsprogrammet understøtter således på unik vis hospitalets forskerkarriéreprogram med fremragende forskere og forskningsmiljøer i pipelinen. På baggrund af det store antal af højt kvalificerede forskere, der ikke har opnået delestilling og på baggrund af afdelingernes og forskernes input fra site visits, ved vi, at der er et yderligere stort behov for skemalagt forskningstid. Hospitalsdirektionen og Forskningsenheden har derfor taget initiativ til oprettelse af et antal delestillinger (20 % forskning) for læger i hoveduddannelse med et forskningsprojekt tilknyttet Gentofte Hospital. I 2014 kørte et pilotforløb på denne stillingstype, og med disse erfaringer i bagagen planlægges en ny stilling opslået i 2015. Udviklingen i hospitalets forskningsmiljøer peger således fortsat positivt fremad, hvilket også dokumenteres på hospitalets Forskningens Dag, Videnskabeligt Symposium for delestillinger og ved Forskningens Døgn i 2014 (se nedenfor). Det er kendetegnende for forskningsmiljøerne på Gentofte Hospital, at der er en klar bevidsthed omkring snitflader til andre forskergrupper i det nu fusionerede Herlev og Gentofte Hospital, og der er en skærpet opmærksomhed på identiteten som aktiv forsker i denne virksomhed, der er Region Hovedstadens næststørste forskningshospital. På vegne af Forskningsenheden i Kvalitet og Udvikling Jüri J. Rumessen Forskningschef, dr.med. 2 Gentofte Matrikel Herlev og Gentofte Hospital August 2015 Forskningsråd Gentofte Forskningsråd Gentofte består af forskningsansvarlige repræsentanter fra hospitalets afdelinger og skal rådgive Direktionen i forskningsrelaterede spørgsmål og løse en række konkrete opgaver relateret til forskning. I 2014 afholdt Forskningsrådet 4 møder. Sammensætning af Forskningsrådet: 3 professorer, 3 seniorforskere, 3 forskningsaktive med MVU-grunduddannelse samt hospitalets 2 sundhedsfaglige vicedirektører, hvoraf den forskningsansvarlige vicedirektør er formand. Medlemmer af Forskningsråd Gentofte ultimo 2014 Vicedirektør, Lars Juhl Petersen (formand) Vicedirektør, Jan Toftholm Andersen Professor, overlæge dr.med., Lone Skov Professor, overlæge, ph.d., Gunnar Gislason Professor, overlæge dr.med. Tina Vilsbøll Ledende overlæge, dr.med., Steen Stender Overlæge, dr.med., Ole Rintek Madsen Overlæge, dr.med., Anders Odgaard Hospitalsdirektionen Hospitalsdirektionen Hud og Allergiafd. Hjertemedicinsk afd. Medicinsk afd. F Klinisk biokemisk afd. Medicinsk afd. C Ortopædkirurgisk afd. Forskningsansvarlig sygeplejerske, cand.mag. Eline Noiesen Medicinsk afd. F Forskningsansvarlig sygeplejerske, MVO Ingelise Trosborg Sygeplejerske, cand.cur, ph.d. stud. Kirsten Szöts Lungemedicinsk afd. Ordopædkirurgisk afd. Forskningschef, specialeansvarlig overlæge, dr.med. Jüri Rumessen Forskningsleder, ph.d., postdoc Hanne Konradsen Forskningskonsulent, cand.scient.adm. Camilla Nymann Forskningskonsulent, korrespondent Lone Falck Forskningsenheden Forskningsenheden Forskningsenheden Forskningsenheden 3 Forskningsenheden Forskningsenheden bor i Kvalitet og Udvikling på adressen: Kildegårdsvej 28, opg. 65, 1.th 2900 Hellerup Forskningsenheden består af 4 medarbejdere: Forskningschef Jüri Rumessen (specialeansvarlig overlæge, dr.med) Tlf.:3867 3987 Tlf.: 3867 7250 [email protected] Forskningskonsulent Camilla Nymann (Cand.scient.adm) Tlf.: 3867 7228 [email protected] Forskningsleder Hanne Konradsen (Med.HRD., cand.cur., ph.d, postdoc) [email protected] Forskningskonsulent Lone Falck (Korrespondent, merkonom IT) Tlf.: 3867 3988 [email protected] Ph.d. studiemiljø Forskningsenheden administrerer et ph.d. studiemiljø i en hyggelig kvistlejlighed på Kildegårdsvej 28, opg.65, 2. Her findes faciliteter for studerende blandt hospitalets ansatte læger, sygeplejersker og andet sundhedsfagligt personale: 6 arbejdspladser – heraf 5 udstyret med PC og fast IT opkobling Farveprinter, kopimaskine, telefon, div. kontorfaciliteter Aflåselige arkivskabe Minibibliotek med faste abonenmenter på en række faglige tidsskrifter Fælles mødelokale Henvendelse: [email protected] 4 Forskerkarriereprogram på Gentofte Hospital Hospitalsdirektionen har afsat betydelige midler til konsolidering og udbygning af hospitalets forskerkarriereprogram. I fuldt udbygget form vil dette omfatte sammenhængende videnskabelige karrierespor på alle niveauer lige fra sundhedspersoner under uddannelse til akademiske slutstillinger. Den grundlæggende idé er forskningsdelestillinger og uddannelse i forskningsledelse i sammenhæng og synergi med hospitalets kliniske funktioner. Forskerdelestillinger Hospitalsdirektionen har fra 2012 og frem afsat 5 mio. kr. årligt til oprettelse af delestillinger på hospitalet. Stillingerne indebærer delefunktion mellem 50 % klinisk arbejde eller anden hidtidig beskæftigelse og 50 % forskning. Delestillingerne repræsenterer en stor forskningssatsning for at imødekomme det store behov for både forskerdelestillinger og for karrierespor for kvalificerede kliniske forskere efter ph.d.-graden og på seniorforskerniveau. Igangværende delestillinger som postdocs og seniorforskere ved Gentofte Hospital 2014 5-årig seniorforsker delestilling Thomas Almdal, overlæge, dr.med., Medicinsk afd. F Peter Riis Hansen, overlæge, dr.med., Hjertemedicinsk afd. 4-årig seniorforsker delestilling Anders Odgaard, overlæge, dr.med., Ortopædkirurgisk afd. 4-årig postdoc delestilling Hanne Konradsen, sygeplejerske, ph.d., Forskningsenheden i HR & Kvalitet Lene Heise Garvey, overlæge, ph.d., Hud- og allergiafd. 3-årig seniorforsker delestilling Marianne Benn, overlæge, dr.med., Klinisk Biokemisk afd. Ole Rintek, overlæge dr.med, Medicinsk afd. C 2-årig seniorforsker delestilling Lene Dreyer, overlæge, ph.d., Medicinsk afd. C Paul F. Clementsen, overlæge, ph.d., Lungemedicinsk afd. Jørgen Rungby, overlæge, dr.med., adj. professor, Medicinsk afd. F 5 Forskningspuljer 2014 I 2014 opdelte Forskningsrådet forskningspuljerne i en START-pulje for ansatte med MVU grunduddannelse og en Strategisk forskningspulje for alle ansatte. Forskningsrådet lagde i sine bedømmelser vægt på, at projektet passer ind i hospitalets overordnede strategiske prioritering. START puljen 2014 Strategisk forskningspulje 2014 Kunne søges af alle ansatte på Gentofte Hospital. STARTpuljen til anvendelse blandt ansatte med MVU (Mellemlang Videregående Uddannelse) kunne i 2014 I Gentofte Hospitals strategi for forskning er et af søges af både enkeltpersoner og afdelinger. indsatsområderne prioritering af implementering af forskningsresultater. Midlerne tildeles spirende forskere og/eller forskningsområder, som ville have vanskeligt ved at opnå støtte Puljens formål i 2014 var at støtte et eller flere andetsteds, hvilket oftest svarer til 2-3 måneders løn. forskningsprojekter med fokus på implementering af forskningsresultater. Uddelinger i 2014: Puljen var på i alt kr. 300.00 Behovsstyrede patientforløb Lina Khoury, stud.scient.san. Hud- og Allergiafdeling Bevilget beløb: kr. 105.351 Uddelinger i 2014: Implementering af forskningsresultater - en undersøgelse af implementeringspraksis på Gentofte Hospital Et projekt i HR & Kvalitet Nanna Kristensen Bevilget beløb: kr. 250.000 Udarbejdelse af to review artikler, der dokumenterer den eksisterende viden i forhold til ikke-medikamentel forebyggelse og behandling af forstoppelse Marie Louise Thise Rasmussen, sygeplejerske, Master Public Health Medicinsk afdeling F Bevilget beløb: kr. 127.293 Implementeringsprocesser på en klinisk biokemisk afdeling med fokus på tværfaglige implementeringer og Klinisk Biokemisk afdelings bidrag til optimering af patientforløb Et projekt i Klinisk Biokemisk afd. Vandladningsproblemer hos indlagte reumatologiske patienter Pernille Friis Rønne, sygeplejerske, stud. Master sundhedsantropologi Medicinsk afdeling C Bevilget beløb: kr. 43.006 Eva Reinholdt m.fl. Bevilget beløb: kr. 50.000 6 Forskningens Døgn 2014 Forskningens Døgn den 24. april var en stor succes. Ca. 200 borgere lyttede til den nyeste viden inden for sygdom og sundhed. Det skete ved en perlerække af foredrag med Gentofte Hospitals fremmeste forskere i Store Auditorium. Borgerne fik mulighed for stille spørgsmål til forskerne om deres forskellige indlæg og bud på, hvad vi skal forske i på Gentofte Hospital. Forskningens Døgn er en landsdækkende begivenhed, hvor alle typer af forskningsinstitutioner inviterer indenfor til en dag i forskningens tegn. PROGRAM Velkomst og praktisk info Vicedirektør Lars Juhl Petersen Hjerterytme-målinger hos vilde bjørne Læge, ph.d. stud. Peter Godsk Jørgensen Hvorfor giver tør hud eksem? 1. reservelæge, dr.med., ph.d., Jacob Thyssen Hvorfor sover vi så dårligt på hospitalet? Klinisk sygeplejespecialist, cand.mag. Eline Noiesen Hurtigt ud af sengen efter hofteproteseoperation. Hvorfor det? Overlæge, dr.med. Søren Solgaard Pause med åbne stande Kan type 2-diabetes forebygges? Professor, overlæge, dr.med. Tina Vilsbøll Hvilke produkter giver parfumeallergi? Læge, ph.d. Maria Vølund Heisterberg Kan man minimere bivirkninger ved kolesterolsænkende statinbehandling? Ledende overlæge, dr.med. Steen Stender Videnskabsjournalist og bl.a. kendt fra videnskabsprogrammer på DR, Anja Philip, var dagens programvært. Hun bandt de forskellige oplæg sammen. 7 I pausen kunne borgerne bl.a. få målt balance, muskelstyrke, lungekapacitet, blodsukker, BMI og prøve en ultralydskanning. Kræftens Bekæmpelse viste på en udendørs stand, hvordan kræft og betændelse ser ud på et billede. Forskningens Dag 2014 Forskningens Dag er et internt medarbejderarrangement, som Forskningsrådet afholdt den 26. november 2014. Det var endnu engang rekordernes dag: 64 abstracts blev præsenteret ved bemandede postere i auditoriebygningens forhal og 8 foredrag (udvalgt blandt 48 foredrags-ansøgninger). Præmiesummen var i alt kr. 50.000. Et dommerpanel gik diskret rundt og vurderede de mange flotte og videnstunge posters og lyttede intenst til de 8 oplæg i auditoriet. Beslutningen var svær, men de velfortjente vindere af titlerne dagens bedste to foredrag og bedste tre posters blev fundet. Omtrent 150 forskere, studerende og andre nysgerrige sugede ny viden til sig under de interessante foredrag, der gav stof til eftertanke. Dagens første key note speaker var Mads Melbye, professor, dr.med., og direktør National Sundhedsdokumentation og Forskning, Statens Serum Institut. Mads Melbye talte om Danmark som laboratorium med de mange unikke databaser over befolkningen Dagens anden key note speaker var professor Henning Boje Andersen fra Safety & Risk Management Group, DTU Management Engineering. VINDERNE 1. præmie foredrag på kr. 25.000 gik til Ann-Marie Malby Schoos, Copsac, Hud- og Allergiafd. 2. præmie foredrag på kr. 10.000 gik til Ulrich Rohde, Center for Diabetes, Medicinsk afd. F Posterpræmier á kr. 5.000 gik til: - Sidse Graff Jensen, Lungemedicinsk afd. - Kasper Søndergaard, Medicinsk afd. C - Johannes Waage, Copsac, Hud- & Allergiafd. 8 Forskningstemaer, -personale og -publikationslister 2014 Forskningspublikationerne udgået fra Gentofte Hospital i 2014 er oprettet i og trukket fra forskningsregistreringssystemet PURE, der blev indført i Region Hovedstaden i 2010. I grafer og på publikationslisterne vises kun afdelingernes indberetning i PURE indenfor kategorien peer reviewed forskning udgivet i 2014. Derfor er alle publikationer på listen pointgivende i regionens forskningsevaluering. Da vi har et stort samarbejde på tværs af afdelingerne, kan den samme publikation være registreret i publikationslisten på flere afdelinger, hvorfor en sammenlægning af alle afdelingernes publikationsantal være lidt højere end den samlede total for Gentofte, idet de tværgående publikationer kun tælles med én gang i Gentofte-totalen. Publikationernes individuelle bibliometriske identifikation er også medtaget. Nedenstående diagram viser fordeling af peer-reviewede tidsskriftsartikler udgået fra Gentofte Hospital i 2014 fordelt på afdelinger. Se nærmere specifikationer i de følgende afsnit. Kilde: Kilde: PURE rapport trukket i rapportmodul juli 2015 9 Anæstesi afd. Forskningstemaer Genoplivede hypotermi behandlede patienter efter hjertestop; 7- og 30 dages mortalitet NAPS (nurse administrated propofol sedation); opgørelse af hypoxi episoder og relation til søvnapnø Ultralydsvejledte nerveblokader Videnskabelige medarbejdere Nina Vendel Jensen, forsknings- og operationssygeplejerske Forskningsansvarlig overlæge Ulrik Grevstad, overlæge Forskningsansvarlig sygeplejerske Maria Bergholt, klinisk sygeplejespecialist Publikationer 2014 1. Espelund M, Grevstad U, Jaeger P, Hölmich P, Kjeldsen LE, Mathiesen O et al. Adductor canal blockade for moderate to severe pain after arthroscopic knee surgery: a randomized controlled trial. Acta anaesthesiologica Scandinavica. 2014 nov;58(10):1220-7. Tilgængelig fra: 10.1111/aas.12407 2. Grevstad U, Mathiesen O, Lind T, Dahl JB. Effect of adductor canal block on pain in patients with severe pain after total knee arthroplasty: a randomized study with individual patient analysis. British Journal of Anaesthesia. 2014 jan 8;112(5):912-19. Tilgængelig fra: 10.1093/bja/aet441 3. Konradsen H, Trosborg I, Christensen L, Pedersen PU. Evaluation of interrater reliability assessing oral health in acute care settings. International Journal of Nursing Practice. 2014;20:258. Tilgængelig fra: 10.1111/ijn.12140 4. Konradsen H, Trosborg I, Christensen L, Thomsen T, Pedersen PU. Who needs oral care? A study of potential factors associated with the need for oral care. Journal of Nursing Education and Practice. 2014;4(11):16-22. Tilgængelig fra: http://dx.doi.org/10.5430/jnep.v4n11p16 5. Ravn P, Foster DJR, Kreilgaard M, Christrup L, Werner MU, Secher EL et al. Pharmacokinetic-pharmacodynamic modelling of the analgesic and antihyperalgesic effects of morphine after intravenous infusion in human volunteers. Basic & clinical pharmacology & toxicology. 2014 sep;115(3):257-67. Tilgængelig fra: 10.1111/bcpt.12213 10 Ernæringsenheden i Serviceafdelingen Publikationer 2014 1. Aller EEJG, Larsen TM, Holst C, Lindroos AK, Kafatos A, Pfeiffer A et al. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results. International journal of obesity (2005). 2014 mar 28;38(12):1511-1517. Tilgængelig fra: 10.1038/ijo.2014.52 2. Ankarfeldt MZ, Ängquist LH, Stocks T, Jakobsen MU, Overvad K, Halkjær J et al. Body Composition, Dietary Protein and Body Weight Regulation. Reconciling Conflicting Results from Intervention and Observational Studies?. P L o S One. 2014;9(7):e101134. Tilgængelig fra: 10.1371/journal.pone.0101134 3. Ankarfeldt MZ, Ängquist LH, Jakobsen MU, Overvad K, Tjønneland A, Halkjaer J et al. Interactions of dietary protein and adiposity measures in relation to subsequent changes in body weight and waist circumference. Obesity (Silver Spring, Md.). 2014 jun 19;22(9):2097–2103. Tilgængelig fra: 10.1002/oby.20812 4. Geiker N, Myint KS, Heck P, Dhatariya K, Hørup Larsen SM, Andersen MR et al. Intentional Weight Loss Improved Performance in Obese Ischaemic Heart Patient: A Two Centre Intervention Trial. Jacobs journal of food and nutrition. 2014;1(1). 003. 5. Hare KJ, Bonde L, Svare JA, Randeva HS, Asmar M, Hørup Larsen SM et al. Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabetic Medicine Online. 2014 aug;31(8):936-40. Tilgængelig fra: 10.1111/dme.12436 6. Jensen P, Zachariae C, Christensen R, Geiker NRW, Schaadt BK, Stender S et al. Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis. Acta Dermatovenereologica. 2014 feb 20;94(6):691-4. Tilgængelig fra: 10.2340/00015555-1824 11 Forskningsenheden i Kvalitet og Udvikling Forskningstemaer 5. Noiesen E, Trosborg I, Bager L, Herning M, Lyngby C, Konradsen H. Constipation prevalence and incidence among medical patients acutely admitted to hospital with a medical condition. Journal of Clinical Nursing. 2014 aug 1;23(15-16):2295-2302. Tilgængelig fra: 10.1111/jocn.12511 6. Szöts K, Konradsen H, Solgaard S, Ostergaard B. Telephone follow-up by nurse following total knee arthroplasty - protocol for a randomized clinical trial (NCT 01771315). B M C Nursing. 2014;13:14. Tilgængelig fra: 10.1186/1472-6955-13-14 7. Telinius N, Baandrup U, Rumessen J, Pilegaard H, Hjortdal VE, Aalkjaer C et al. The human thoracic duct is functionally innervated by adrenergic nerves. A J P: Heart and Circulatory Physiology (Online). 2014 jan;306(2):H206-13. Tilgængelig fra: 10.1152/ajpheart.00517.2013 Klinisk og epidemiologisk forskning i cøliaki og malabsorption Grundvidenskabelige og translatoriske forskningsprojekter vedrørende strukturel cellebiologi og glatmuskelfunktion Deskriptive studier af patientkarakteristika Evaluering af patientnære screeningsprogrammer Klinisk randomiserede sygeplejeinterventioner Forskningsmetode udvikling Klinisk og epidemiologisk forskning i tuberkulose Implementeringsforskning: hvorledes der på ud- Kommentar/debat 8. valgte kliniske afdelinger arbejdes med implementering af evidensbaserede forskningsresultater Wildt S, Lassen IN, Rumessen JJ. Incorrect citation and analysis in meta-analysis. Inflammatory Bowel Diseases. 2014;20(12):E25. Tilgængelig fra: 10.1097/MIB.0000000000000249 Videnskabelige medarbejdere Bidrag til bog/antologi Hanne Konradsen, Forskningsleder, sygeplejer- 9. ske, cand.cur. ph.d. Jüri Rumessen, Forskningschef, dr. med. Nanna Kristensen, cand.psych. og organisationskonsulent Publikationsliste 2014 1. Hansen C, Konradsen H, Abrahamsen B, Pedersen B. Women’s experiences of their osteoporosis diagnosis at the time of diagnosis and six months later: a Phenomenological-hermeneutic Study. International Journal of Qualitative Studies on Health and Well-Being. 2014;22438. Tilgængelig fra: doi.org/10.3402/qhw.v9.22438 2. Konradsen H, Lillebaek T, Wilcke JTR, Lomborg K. Being publicly diagnosed: A grounded theory study of Danish patients with tuberculosis. International Journal of Qualitative Studies on Health and Well-Being. 2014;9:1-8. 3. Konradsen H, Trosborg I, Christensen L, Pedersen PU. Evaluation of interrater reliability assessing oral health in acute care settings. International Journal of Nursing Practice. 2014;20:258. Tilgængelig fra: 10.1111/ijn.12140 4. Konradsen H, Trosborg I, Christensen L, Thomsen T, Pedersen PU. Who needs oral care? A study of potential factors associated with the need for oral care. Journal of Nursing Education and Practice. 2014;4(11):16-22. Tilgængelig fra: http://dx.doi.org/10.5430/jnep.v4n11p16 12 Konradsen H. Et ændret body image. I Wittrup, Prip, Grube, red., Kræftsygepleje i et forløbsperspektiv. Munksgård Danmark. 2014. s. 111-119. Hjertemedicinsk afd. Forskningstemaer seniorforskere, ph.d.-studerende, skolarstipendiater, På Hjertemedicinsk Afdeling P forskes både klinisk i og forskningssygeplejersker. diagnostik, behandling og pleje af de sygdomme, af- Afdelingen har en del samarbejdspartnere inklusiv delingen som invasivt hjertecenter i Region Hoved- afdelingerne Medicinsk F og C samt Hud- og Allergi på staden varetager behandling af, samt i hjertesyg- Gentofte Hospital, Steno Diabetes Center, Institut for dommes epidemiologi og behandling med anvendelse Eksperimentel Medicin på Århus Universitet, Panumin- af de danske landsdækkende registre. stituttet samt hjerteafdelingerne på Rigshospitalet og De væsentligste fokusområder er: Skejby Sygehus. Derudover har afdelingen et bredt internationalt samarbejde i USA og Europa, hvor flere Diagnostik og behandling af iskæmisk hjertesygdom, hvor nye biokemiske og billeddiagnostiske teknikker med ekkokardiografi og CT- og MR- forskere fra afdelingen er udstationerede ved prestigefyldte institutioner og universiteter bl.a. ved Stanford, scanning, samt ny medicin og nye teknikker ved Duke, Vanderbilt, Framingham, Harvard, Rochester, ballonudvidelser undersøges. Barts and the London School of Medicine og Birming- Store epidemiologiske undersøgelser, specielt in- ham. den for området kardiovaskulær farmakoepidemiologi, hvor de store danske registre, især Landspatientregisteret, Dansk Hjerteregister og Lægemiddelstatistikregisteret, anvendes. Ekkokardiografisk vejledt behandling af svært Der udgår årligt fra afdelingen 130-150 videnskabelige artikler i internationale peer reviewed tidsskrifter samt 6-7 ph.d.-afhandlinger. hjertesvigt med biventrikulær pacemaker eller ICD enhed. Forskningen finansieres dels via de store fonde, dels Tidlig opsporing af hjertesygdom ved diabetes. via samarbejde med industrien. Sammenhængen mellem inflammation og hjertesygdom. Diagnostik og behandling af infektiøs endokarditis (hjerteklap-betændelse). Afdelingen blev i 2011 – som eneste hjerteafdeling i Danmark - udnævnt til Center of Global Afdelingen er påbegyndt et meget omfattende Excellence for forskning, patientbehandling og projekt inden for genetisk epidemiologi ved hjer- pleje i international særklasse. tesygdom, ligesom undersøgelser af nye teknikker ved kateterbaseret radiofrekvensablation (over- Videnskabelige medarbejdere brænding) af hurtige hjerterytme-forstyrrelser er i Professorer planlægningsfasen. Jan Skov Jensen, ledende overlæge, ph.d., dr. Sygeplejebaserede registerstudier om patienters med. selvvurderede helbred ved udskrivelse fra hjerte- Gunnar Gislason, overlæge, ph.d. center. Niels Eske Bruun, overlæge, dr.med. Kvalitativt baseret sygeplejeforskning med fokus på patienters oplevelse i forbindelse med at have Kliniske forskningslektor og en hjertesygdom. Seniorforsker delestilling Peter R. Hansen, overlæge, dr.med., ph.d. Afdelingen har to professorer ved Købehavns Universitet: Ledende overlæge, dr.med., ph.d. Jan Skov Seniorforskere/Post.docs Jensen, og overlæge, ph.d. Gunnar Gislason. Gunnar Christian Torp-Pedersen, professor Selina Kikkenborg Berg, ph.d., Gislason er også adjungeret professor ved Syddansk. post.doc./projektleder Overlæge, dr.med. Niels Eske Bruun er adjungeret Christian Jøns, 1. reservelæge, ph.d. professor ved Aalborg Universitet. Overlæge, Rasmus Møgelvang, 1. reservelæge, ph.d. dr.med., ph.d, Peter Riis Hansen er klinisk forsk- Morten Lock Hansen, 1. reservelæge, ph.d. ningslektor ved Københavns Universitet. Derudover Fredrik Folke, 1. reservelæge, ph.d. er der i afdelingen ansat en meget stor stab af Rikke Sørensen, 1. reservelæge, ph.d 13 Charlotte Andersson, ph.d., post.doc Andet forskningsaktivt personale Speciallæger Ph.d. studerende Jan Kyst Madsen, overlæge, dr. med. Helle Carstensen Ulrik Abildgaard, overlæge, dr. med. Magnus Thorsten Jensen Jan Bech, overlæge, ph.d. Jacob Sivertsen Søren Galatius, overlæge, dr. med. Peter Weeke Jim Hansen, overlæge, dr. med. Søren Østergaard Lindberg Thomas Fritz Hansen, overlæge Peter Godsk Jørgensen Jens Haarbo, overlæge, dr. med. Tor Biering-Sørensen Michael Vinther, overlæge, ph.d. Carolina Malta Hansen Arne Johannessen, overlæge, dr. med. Deniz Karasoy Peter Skøtt, overlæge, dr. med. Martin Huth Ruwald René Worck, overlæge, ph.d. Morten Lamberts Tommi Bo Lindhardt, overlæge, ph.d. Mads Wissenberg Jørgensen Charlotte Larroudé, afdelingslæge, ph.d. Jacob Schmidt Jørgen K. Kanters, lektor ved Københavns Universitet Kim Wadt Hansen – tilknyttet elektrofysiologisøjle Adam Pena Louise Eske Bruun Sygeplejersker Anders Dahl Margrethe Herning, klinisk sygeplejespecialist Trine Kiilerich Lauridsen Stefan Christensen Projektsygeplejersker/bioanalytikere Søren Lund Kristensen Camilla Böhne, projektsygeplejerske Lars Lindberg Sørensen Lena Fahlström, projektsygeplejerske Michelle Schmiegelow Henriette Bjørnager Jensen, projektsygeplejerske Anne-Marie Schjerning Olsen Ulla H. Jakobsen, projektsygeplejerske Karl Emil Kristensen Gitte von Jessen, projektsygeplejerske Martina de Knegt Julie Laage-Petersen, projektsygeplejerske Christina Alhede Jette S. Madsen, projektsygeplejerske Gorm Mørk Hansen Lene Høgh Simonsen, projektsygeplejerske Shahzleen Rajan Flemming Bjerre, projektsygeplejerske Kathrine Bach Søndergaard Britt Falskov Forskningsansvarlig overlæge Jonas Bjerring Olesen Jan Skov Jensen, ledende overlæge, professor, ph.d., Charlotte Mérie dr.med. Jesper Lindhardsen Anne Gjesing Olesen Forskningsansvarlig sygeplejerske Anne Christine Huth Ruwald Margrethe Herning, forskningsansvarlig sygeplejerske, MSU Skolarstipendiater / studenter Jonas Krogh Jensen Publikationsliste 2014 Thomas Bo Jensen Aziza Azimi 1. Ahlehoff O, Gislason G, Hansen PR. Cardiovascular aspects of psoriasis: an updated review. International Journal of Dermatology. 2014 jun;53(6):e337. Tilgængelig fra: 10.1111/ijd.12267 2. Ahlehoff O, Skov L, Gislason G, Gniadecki R, Iversen L, Bryld LE et al. Cardiovascular outcomes and systemic anti-inflammatory drugs in patients with severe psoriasis: 5-year follow-up of a Danish nationwide cohort. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014 okt 10. Tilgængelig fra: 10.1111/jdv.12768 3. Andersen TR, Schmidt JF, Thomassen M, Hornstrup T, Frandsen U, Randers MB et al. A preliminary study: effects of football training on glucose control, body composition, and performance in men with type 2 diabetes. Scandinavian journal of medicine & science in sports. 2014 aug;24 Suppl 1:43-56. Tilgængelig fra: 10.1111/sms.12259 Anders Mikkelsen Esma Salahadeen Morten Winther Hvidtfeldt Signe Abitz Winther Maria Dons Flemming Javier Olsen Lena Karlsson Anna-Karin Numé Anna Sofia Larsson Anders Nissen Bonde 14 4. Andersen LJ, Randers MB, Hansen PR, Hornstrup T, Schmidt JF, Dvorak J et al. Structural and functional cardiac adaptations to 6 months of football training in untrained hypertensive men. Scandinavian journal of medicine & science in sports. 2014 aug;24 Suppl 1:27-35. Tilgængelig fra: 10.1111/sms.12237 5. Andersson C, Gislason GH, Hlatky MA, Søndergaard KB, Pallisgaard J, Smith JG et al. A risk score for predicting 30-day mortality in heart failure patients undergoing non-cardiac surgery. European Journal of Heart Failure. 2014 dec;16(12):1310-6. Tilgængelig fra: 10.1002/ejhf.182 6. Andersson C, Mérie C, Jørgensen M, Gislason GH, Torp-Pedersen C, Overgaard C et al. Association of β-Blocker Therapy With Risks of Adverse Cardiovascular Events and Deaths in Patients With Ischemic Heart Disease Undergoing Noncardiac Surgery: A Danish Nationwide Cohort Study. JAMA internal medicine. 2014;174(3):336-344. Tilgængelig fra: 10.1001/jamainternmed.2013.11349 7. 8. 9. 19. Berg SK, Svanholm JR, Lauberg A, Borregaard B, Herning M, Mygind A et al. Patient-reported outcomes at hospital discharge from Heart Centres, a national cross-sectional survey with a register-based follow-up: the DenHeart study protocol. B M J Open. 2014;4(5):e004709. Tilgængelig fra: 10.1136/bmjopen-2013004709 20. Biering-Sørensen T, Jensen JS, Pedersen S, Galatius S, Hoffmann S, Jensen MT et al. Doppler Tissue Imaging Is an Independent Predictor of Outcome in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2014 mar;27(3):258-67. Tilgængelig fra: 10.1016/j.echo.2013.11.005 21. Biering-Sørensen T, Hoffmann S, Mogelvang R, Zeeberg Iversen A, Galatius S, Hansen TF et al. Myocardial strain analysis by 2-dimensional speckle tracking echocardiography improves diagnostics of coronary artery stenosis in stable angina pectoris. Circulation. Cardiovascular Imaging. 2014 jan 1;7(1):58-65. Tilgængelig fra: 10.1161/CIRCIMAGING.113.000989 Andersson C, Shilane D, Go AS, Chang TI, Kazi D, Solomon MD et al. Betablocker therapy and cardiac events among patients with newly diagnosed coronary heart disease. Journal of the American College of Cardiology. 2014 jul 22;64(3):247-52. Tilgængelig fra: 10.1016/j.jacc.2014.04.042 22. Blicher TM, Hommel K, Kristensen SL, Torp-Pedersen C, Madsen M, Kamper AL et al. Benefit of clopidogrel therapy in patients with myocardial infarction and chronic kidney disease-a Danish nation-wide cohort study. J.Am.Heart Assoc. 2014 aug;3(4):1-10. Tilgængelig fra: doi: 10.1161/JAHA.114.001116 Andersson C, Vasan RS. Compiling the complement of genes implicated in coronary artery disease. Circulation. Cardiovascular genetics. 2014 dec;7(6):73840. Tilgængelig fra: 10.1161/CIRCGENETICS.114.000909 23. Bligaard N, Thuesen L, Saunamäki K, Thayssen P, Aarøe J, Hansen PR et al. Similar five-year outcome with paclitaxel- and sirolimus-eluting coronary stents. Scandinavian cardiovascular journal : SCJ. 2014 jun;48(3):148-55. Tilgængelig fra: 10.3109/14017431.2014.883461 Andersson C, Vasan RS. Epidemiology of heart failure with preserved ejection fraction. Heart Failure Clinics. 2014 jul;10(3):377-88. Tilgængelig fra: 10.1016/j.hfc.2014.04.003 24. Bonde AN, Lip GYH, Kamper A-L, Hansen PR, Lamberts M, Hommel K et al. Net Clinical Benefit of Antithrombotic Therapy in Patients With Atrial Fibrillation and Chronic Kidney Disease: A Nationwide Observational Cohort Study. Journal of the American College of Cardiology. 2014 dec 16;64(23):2471-82. Tilgængelig fra: 10.1016/j.jacc.2014.09.051 10. Andersson C, Vasan RS. Is there a role for coronary artery calcium scoring for management of asymptomatic patients at risk for coronary artery disease?: Clinical risk scores are sufficient to define primary prevention treatment strategies among asymptomatic patients. Circulation. Cardiovascular Imaging. 2014 mar;7(2):390-7; discussion 397. Tilgængelig fra: 10.1161/CIRCIMAGING.113.000470 11. Andersson C, Jørgensen ME, Martinsson A, Hansen PW, Gustav Smith J, Jensen PF et al. Noncardiac surgery in patients with aortic stenosis: a contemporary study on outcomes in a matched sample from the Danish health care system. Clinical Cardiology (Hoboken). 2014 nov;37(11):680-6. Tilgængelig fra: 10.1002/clc.22324 25. Borgquist R, Haugaa KH, Gilljam T, Bundgaard H, Hansen J, Eschen O et al. The diagnostic performance of imaging methods in ARVC using the 2010 Task Force criteria. European heart journal cardiovascular Imaging. 2014 nov;15(11):1219-25. Tilgængelig fra: 10.1093/ehjci/jeu109 26. Bruun NE, Habib G, Thuny F, Sogaard P. Cardiac imaging in infectious endocarditis. European Heart Journal. 2014 mar;35(10):624-632. Tilgængelig fra: 10.1093/eurheartj/eht274 27. Bølling R, Scheller NM, Køber L, Poulsen HE, Gislason GH, Torp-Pedersen C. Comparison of the clinical outcome of different beta-blockers in heart failure patients: a retrospective nationwide cohort study. European Journal of Heart Failure. 2014 jun;16(6):678-684. Tilgængelig fra: 10.1002/ejhf.81 12. Asferg CL, Nielsen SJ, Andersen UB, Linneberg A, Møller DV, Hedley PL et al. Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men. American Journal of Hypertension. 2014 apr;27(4):620-627. Tilgængelig fra: 10.1093/ajh/hpt145 28. Carlson N, Dixen U, Marott JL, Jensen MT, Jensen GB. Predictive value of casual ECG-based resting heart rate compared with resting heart rate obtained from Holter recording. Scandinavian Journal of Clinical & Laboratory Investigation. 2014 mar;74(2):163-9. Tilgængelig fra: 10.3109/00365513.2013.867531 13. Bang CN, Gerdts E, Aurigemma GP, Boman K, de Simone G, Dahlöf B et al. Four-group classification of left ventricular hypertrophy based on ventricular concentricity and dilatation identifies a low-risk subset of eccentric hypertrophy in hypertensive patients. Circulation. Cardiovascular Imaging. 2014 maj;7(3):422-9. Tilgængelig fra: 10.1161/CIRCIMAGING.113.001275 29. Christensen L, Krieger DW, Højberg S, Pedersen OD, Karlsen FM, Jacobsen MD et al. Paroxysmal atrial fibrillation occurs often in cryptogenic ischaemic stroke. Final results from the SURPRISE study. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2014 jun;21(6):8849. Tilgængelig fra: 10.1111/ene.12400 14. Bang CN, Gislason GH, Greve AM, Bang CA, Jørgensen AL, Torp-Pedersen C et al. New-onset atrial fibrillation is associated with cardiovascular events leading to death in a first time myocardial infarction population of 89,703 patients with long-term follow-up: a nationwide study. Journal of the American Heart Association. 2014 feb;3(1):e000382. Tilgængelig fra: 10.1161/JAHA.113.000382 15. Bang CN, Okin PM, Køber L, Wachtell K, Gottlieb AB, Devereux RB. Psoriasis is associated with subsequent atrial fibrillation in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint study. Journal of hypertension. 2014 mar;32(3):667-72. Tilgængelig fra: 10.1097/HJH.0000000000000078 16. Bang CN, Greve AM, Køber L, Rossebø AB, Ray S, Boman K et al. Reninangiotensin system inhibition is not associated with increased sudden cardiac death, cardiovascular mortality or all-cause mortality in patients with aortic stenosis. International Journal of Cardiology. 2014 aug 20;175(3):492-8. Tilgængelig fra: 10.1016/j.ijcard.2014.06.013 30. Christiansen M, Hedley PL, Theilade J, Stoevring B, Leren TP, Eschen O et al. Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2. B M C Medical Genetics. 2014;15:31. Tilgængelig fra: 10.1186/1471-2350-15-31 31. Darkner S, Chen X, Hansen J, Pehrson S, Johannessen A, Nielsen JB et al. Recurrence of arrhythmia following short-term oral AMIOdarone after CATheter ablation for atrial fibrillation: a double-blind, randomized, placebo-controlled study (AMIO-CAT trial). European Heart Journal. 2014 dec 14;35(47):3356-64. Tilgængelig fra: 10.1093/eurheartj/ehu354 32. de Knegt MC, Biering-Sørensen T, Søgaard P, Sivertsen JC, Jensen JS, Møgelvang R. Concordance and reproducibility between M-mode, tissue Doppler imaging, and two-dimensional strain imaging in the assessment of mitral annular displacement and velocity in patients with various heart conditions. European Heart Journal Cardiovascular Imaging. 2014 jan;15(1):62-9. Tilgængelig fra: 10.1093/ehjci/jet119 17. Bang CN, Gislason GH, Greve AM, Torp-Pedersen C, Køber L, Wachtell K. Statins reduce new-onset atrial fibrillation in a first-time myocardial infarction population: a nationwide propensity score-matched study. European journal of preventive cardiology. 2014 mar;21(3):330-8. Tilgængelig fra: 10.1177/2047487312462804 33. Demant MN, Gislason GH, Køber L, Vaag A, Torp-Pedersen C, Andersson C. Association of heart failure severity with risk of diabetes: a Danish nationwide cohort study. Diabetologia. 2014 aug;57(8):1595-600. Tilgængelig fra: 10.1007/s00125-014-3259-z 18. Bang UC, Hyldstrup L, Jensen JEB. The impact of recombinant parathyroid hormone on malignancies and mortality: 7 years of experience based on nationwide Danish registers. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2014;25:639-644. Tilgængelig fra: 10.1007/s00198-013-2470-y 34. D'Souza M, Saaby L, Poulsen TS, Diederichsen ACP, Hosbond SE, Diederichsen SZ et al. Comparison of mortality in patients with acute myocardial infarction accidentally admitted to non-cardiology departments versus that in patients admitted to coronary care units. The American journal of cardiology. 2014 okt 15;114(8):1151-7. Tilgængelig fra: 10.1016/j.amjcard.2014.07.035 15 35. Ejlskov L, Mortensen RN, Overgaard C, Christensen L, Vardinghus-Nielsen H, Kræmer SRJ et al. Individual social capital and survival: a population study with 5-year follow-up. B M C Public Health. 2014;14:1025. Tilgængelig fra: 10.1186/1471-2458-14-1025 52. Jensen P, Zachariae C, Christensen R, Geiker NRW, Schaadt BK, Stender S et al. Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis. Acta Dermatovenereologica. 2014 feb 20;94(6):691-4. Tilgængelig fra: 10.2340/00015555-1824 53. Jensen MT, Sogaard P, Andersen HU, Bech J, Hansen TF, Galatius S et al. Prevalence of systolic and diastolic dysfunction in patients with type 1 diabetes without known heart disease: the Thousand & 1 Study. Diabetologia. 2014 apr;57(4):672-80. Tilgængelig fra: 10.1007/s00125-014-3164-5 36. Ekeløf S, Rosenberg J, Jensen JS, Gögenur I. Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: a systematic review. Journal of Cardiovascular Translational Research. 2014 aug;7(6):570-80. Tilgængelig fra: 10.1007/s12265-014-9574-4 37. Ersbøll M, Valeur N, Hassager C, Søgaard P, Køber L. The association between renal impairment and cardiac structure and function in patients with acute myocardial infarction. American heart journal. 2014 apr;167(4):506-13. Tilgængelig fra: 10.1016/j.ahj.2013.12.029 38. Faber J, Selmer C. Cardiovascular disease and thyroid function. Cardiovascular Issues in Endocrinology. 2014;43:45-56. Tilgængelig fra: 10.1159/000360558 39. Fosbøl EL, Olsen A-MS, Olesen JB, Andersson C, Kober L, Torp-Pedersen C et al. Use of nonsteroidal anti-inflammatory drugs among healthy people and specific cerebrovascular safety. International Journal of Stroke. 2014 okt 9;9(7):943-5. Tilgængelig fra: 10.1111/j.1747-4949.2012.00863.x 40. Gaïni S, Bruun NE, Kollslíð R, Thomsen H, á Steig T, Nielsen KR et al. Whipple's disease involving the eye, the brain, the heart and the gut diagnosed through the eye. Acta Ophthalmologica (Online). 2014 dec;92(8):e693-4. Tilgængelig fra: 10.1111/aos.12454 54. Jespersen L, Abildstrom SZ, Hvelplund A, Madsen JK, Galatius S, Pedersen F et al. Burden of Hospital Admission and Repeat Angiography in Angina Pectoris Patients with and without Coronary Artery Disease: A Registry-Based Cohort Study. P L o S One. 2014 apr 4;9(4):e93170. Tilgængelig fra: 10.1371/journal.pone.0093170 55. Jespersen L, Abildstrøm SZ, Peña A, Hansen PR, Prescott E. Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography. Clinical research in cardiology : official journal of the German Cardiac Society. 2014 jan 20;103(5):381-387. Tilgængelig fra: 10.1007/s00392-014-0665-7 56. Johnsen SP, Svendsen MLO, Hansen ML, Brandes A, Mehnert F, Husted SE. Preadmission oral anticoagulant treatment and clinical outcome among patients hospitalized with acute stroke and atrial fibrillation: a nationwide study. Stroke; a journal of cerebral circulation. 2014 jan;45(1):168-75. Tilgængelig fra: 10.1161/STROKEAHA.113.001792 41. Geiker N, Myint KS, Heck P, Dhatariya K, Hørup Larsen SM, Andersen MR et al. Intentional Weight Loss Improved Performance in Obese Ischaemic Heart Patient: A Two Centre Intervention Trial. Jacobs journal of food and nutrition. 2014;1(1). 003. 57. Jørgensen PG, Jensen JS, Marott JL, Jensen GB, Appleyard M, Mogelvang R. Electrocardiographic changes improve risk prediction in asymptomatic persons age 65 years or above without cardiovascular disease. Journal of the American College of Cardiology. 2014 sep 2;64(9):898-906. Tilgængelig fra: 10.1016/j.jacc.2014.05.050 42. Gjesing A, Gislason GH, Køber L, Gustav Smith J, Christensen SB, Gustafsson F et al. Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997-2010: A Danish cohort study. European journal of internal medicine. 2014 okt;25(8):731-8. Tilgængelig fra: 10.1016/j.ejim.2014.08.009 58. Jørgensen TSH, Hansen AH, Sahlberg M, Gislason GH, Torp-Pedersen C, Andersson C et al. Falls and comorbidity: The pathway to fractures. Scandinavian journal of public health. 2014 maj;42(3):287-94. Tilgængelig fra: 10.1177/1403494813516831 59. Jørgensen PG, Arnemo J, Swenson JE, Jensen JS, Galatius S, Frøbert O. Low cardiac output as physiological phenomenon in hibernating, free-ranging Scandinavian brown bears (Ursus arctos) - an observational study. Cardiovascular Ultrasound. 2014;12:36. Tilgængelig fra: 10.1186/1476-7120-12-36 43. Greve AM, Dalsgaard M, Bang CN, Egstrup K, Ray S, Boman K et al. Stroke in patients with aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis study. Stroke; a journal of cerebral circulation. 2014 jul;45(7):1939-46. Tilgængelig fra: 10.1161/STROKEAHA.114.005296 44. Greve AM, Dalsgaard M, Bang CN, Egstrup K, Rossebø AB, Boman K et al. Usefulness of the electrocardiogram in predicting cardiovascular mortality in asymptomatic adults with aortic stenosis (from the Simvastatin and Ezetimibe in Aortic Stenosis Study). The American journal of cardiology. 2014 sep 1;114(5):751-6. Tilgængelig fra: 10.1016/j.amjcard.2014.06.006 45. Gyldenløve M, Jensen P, Linneberg A, Thyssen JP, Zachariae C, Hansen PR et al. Psoriasis and the Framingham risk score in a Danish hospital cohort. International Journal of Dermatology. 2014 sep;53(9). Tilgængelig fra: 10.1111/ijd.12196 46. Gyldenløve M, Jensen P, Løvendorf MB, Zachariae C, Hansen PR, Skov L. 'Short-term treatment with methotrexate does not affect microvascular endothelial function in patients with psoriasis'. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014 feb 21;1-4. Tilgængelig fra: 10.1111/jdv.12385 47. Hansen GM, Holmstrup P, Tolker-Nielsen T, Køllgaard TMS, Nielsen CH, Givskov M et al. Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom. Ugeskrift for læger [online]. 2014 maj 2. 48. Hedley PL, Carlsen AL, Christiansen KM, Kanters JK, Behr ER, Corfield VA et al. MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome. Scandinavian Journal of Clinical & Laboratory Investigation. 2014 sep;74(6):485-91. Tilgængelig fra: 10.3109/00365513.2014.905696 60. Jørgensen ME, Torp-Pedersen C, Gislason GH, Jensen PF, Berger SM, Christiansen CB et al. Time elapsed after ischemic stroke and risk of adverse cardiovascular events and mortality following elective noncardiac surgery. JAMA : the journal of the American Medical Association. 2014 jul 16;312(3):269-77. Tilgængelig fra: 10.1001/jama.2014.8165 61. Jørgensen CH, Gislason GH, Ahlehoff O, Andersson C, Torp-Pedersen C, Hansen PR. Use of secondary prevention pharmacotherapy after first myocardial infarction in patients with diabetes mellitus. B M C Cardiovascular Disorders. 2014;14:4. Tilgængelig fra: 10.1186/1471-2261-14-4 62. Kanters JK, Yuan L, Hedley PL, Stoevring B, Jons C, Bloch Thomsen PE et al. Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. Circulation journal : official journal of the Japanese Circulation Society. 2014 mar 6;78(5):1136-43. 63. Karlsson LIM, Wissenberg M, Fosbøl EL, Hansen CM, Lippert FK, Bagai A et al. Diurnal variations in incidence and outcome of out-of-hospital cardiac arrest including prior comorbidity and pharmacotherapy: A nationwide study in Denmark. Resuscitation. 2014 jun 24;85(9):1161-1168. Tilgængelig fra: 10.1016/j.resuscitation.2014.06.012 64. Khalid U, Ahlehoff O, Gislason GH, Kristensen SL, Skov L, Torp-Pedersen C et al. Psoriasis and risk of heart failure: a nationwide cohort study. European Journal of Heart Failure. 2014 jul;16(7):743-8. Tilgængelig fra: 10.1002/ejhf.113 49. Hong L, Andersen LJ, Graff C, Vedel-Larsen E, Wang F, Struijk JJ et al. T-wave morphology analysis of competitive athletes. Journal of electrocardiology. 2014 dec 4;48(1):35-42. Tilgængelig fra: 10.1016/j.jelectrocard.2014.10.011 50. Houlind K, Fenger-Grøn M, Holme SJV, Kjeldsen BJ, Madsen SN, Rasmussen BS et al. Graft patency after off-pump coronary artery bypass surgery is inferior even with identical heparinization protocols: results from the Danish On-pump Versus Off-pump Randomization Study (DOORS). Journal of Thoracic and Cardiovascular Surgery. 2014 nov;148(5):1812-1819.e2. Tilgængelig fra: 10.1016/j.jtcvs.2014.02.024 51. Jeger RV, Pfisterer ME, Sørensen R, von Felten S, Alber H, Bonetti PO et al. Tradeoff between bleeding and stent thrombosis in different dual antiplatelet therapy regimes: Importance of case fatality rates and effective treatment durations. American heart journal. 2014 nov;168(5):698-705. Tilgængelig fra: 10.1016/j.ahj.2014.07.019 16 65. Khalid U, Gislason GH, Hansen PR. Sarcoidosis in patients with psoriasis: a population-based cohort study. P L o S One. 2014;9(10):e109632. Tilgængelig fra: 10.1371/journal.pone.0109632 66. Kjøller E, Hilden J, Winkel P, Galatius S, Frandsen NJ, Jensen GB et al. Agreement between public register and adjudication committee outcome in a cardiovascular randomized clinical trial. American heart journal. 2014 aug;168(2):197204.e4. Tilgængelig fra: 10.1016/j.ahj.2013.12.032 67. Kristensen KE, Zhu H-J, Wang X, Gislason GH, Torp-Pedersen C, Rasmussen HB et al. Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-ofconcept study. 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Selmer CLW. Thyroid Dysfunction and Cardiovascular Disease: Epidemiological studies. Faculty of Health and Medical Sciences, University of Copenhagen, 2014. 46 s. 141. Weeke P. Psychiatric Pharmacotherapy and Out-of-Hospital Cardiac Arrest: Nationwide Danish Cohort Studies. 2014. 63 s. Bidrag til bog/antologi 142. Gislason GH, Sørensen R. Triple Therapy: Risky But Sometimes Necessary. I Avanzas P, Peter C, red., Pharmacological Treatment of Acute Coronary Syndromes. Springer. 2014. s. 185-212. Case report 143. Pallisgaard JL, Gang U, Kanters JK, Hansen PR. Massive electrical storm at disease onset in a patient with brugada syndrome. The American Journal of Case Reports. 2014;15:559-61. Tilgængelig fra: 10.12659/AJCR.892314 19 Hud- og Allergiafd. Hud- og Allergiafdelingen består af flere enheder. Forskere, postdocs Dermatologi med et dermato-venerologisk- ambula- Johannes Waage, bioinformatik torium/ behandlingsafsnit og alllergilaboratorium. Al- Anna Hammerich Thysen, immunologi lergologi med et allergiambulatorium og Laboratori- Morten Arendt Rasmussen, kemometri um for Medicinsk Allergologi. Endvidere Dansk Bør- Tarun Veer Singh Ahluwalia, bioinformatik neAstma Center, Videncenter for Allergi og Videncen- Johan de Rool (Amsterdam Universitet), bioinformatik ter for Frisører og Kosmetikere. Ph.d.-studerende Dermatologien og Videncenterne har følgende forsk- Eskil Kreiner-Møller ningstemaer: kontaktallergi (epidemiologi, risikofak- Nadja Hawwa Vissing torer, forebyggelse, genetik og immunologi), atopisk Henrik Hallas eksem, hudbarrieren og gen-miljø interaktioner og Ann-Marie Malby Schoos psoriasis (immunologi, lægemiddeludvikling, comor- Astrid Sevelsted biditet). Helene Mygind Wolsk Dansk BørneAstma Center forsker i astma, allergi og Lambang Arianto eksem på baggrund af to store fødselskohorte studier Sunna Thorsteinsdottir (risikofaktorer; herunder genetik og det humane Jonathan Thorsen mikrobiom, med henblik på bedre behandling og fo- Anna Louise de Barros Damgaard rebyggelse). Allergologien herunder også Laboratorium for Medi- Statistikere cinsk Allergologi har forskningstemaerne: udredning, Sune Birch, statistiker mekanismer og behandling af IgE medieret allergi (inhalationsallergi, fødevareallergi, lægemidler). Administrative medarbejdere Mette Damgaard Nielsen, Forskningsadministrator Forskningstemaer Marianne Mikkelsen, Administrativ Postdoc Kontaktallergi og eksem (privat og arbejdsbetinget) Birgit Marie Nielsen, Økonomisk koordinator Alma Jenny Pedersen, Regnskabsmedarbejder Psoriasis Connie Albinski, Koordinerende sekretær Søren Michael Westenholz, Datamanager Hudbarrieren Dion Aagaard-Hansen, Datamanager Atopisk eksem Brian Vegas Jørgensen, IT-manager IgE medieret allergi (inhalationsallergi, fødevareallergi, lægemidler) Forskningsassistenter Louise Nøttrup Monnerup Lægemiddel udvikling/allergi Pernille Tegner Fjordholt Lena Vind, Bioanalytiker Astma og allergi Katrine Vegener, Laborant Vækst og fedme Prægraduat forskningsstuderende Videnskabelige medarbejdere Ea Cecilie Jelding-Dannemand Patrick René Gerhard Eriksen COPSAC Hans Bisgaard, professor, leder af Dansk BørneAstma Center Josefine Isabella Mainborg Andersen Christina Figgé Christiansen Iben Frier Ruge Seniorforskere Klaus Bønnelykke, Postdoc Studentermedhjælpere Bo Chawes, Postdoc Anna Amalie Jepsen Aga Smilde (Amsterdam Universitet), professor Næstved klinikken (Næstved Sygehus) Jakob Stokholm, Postdoc, seniorforsker Tine-Marie Pedersen, Ph.d. studerende 20 Rebecca Vinding, Ph.d. studerende Ph.d. studerende: Hanne Lunn Nissen, Forskningsassistent David Bregnbak, cand.med. Tobias Sejersen, prægraduat forskningsårstud. Jacob Kåre Ferløv Schwensen, cand.med. Jonas Schmidt, cand scient. Josefine Bandier, cand.med. Klinik for allergi Morten Schjørring Opstrup, cand.med. (sammen med Lars K. Poulsen, professor, dr.med., forskningschef Klink for Allergi) Nina Glasser Hede, cand. scient. Ph.d. studerende: Thomas Dantoft, cand.polyt. (projekt om duft- og kemika- Nanna Juel-Berg lieoverfølsomhed) Lau Fabricius Larsen Ulrik Fischer Friis, cand. polyt. Britta Poulsen Seniorforskere: Seniorforskere: Annette Mollerup, cand. scient.san., ph.d. Lars Blom Berit Christina Carlsen, cand.med., ph.d. Vanesa Esteban Jacob P Thyssen, cand.med, ph.d., dr.med. Lene Heise Garvey Katrine Ross-Hansen, cand.scient., ph.d. Bettina M. Jensen Kåre Engkilde, cand. polyt., ph.d. Maria Vølund Heisterberg, cand.med., ph.d. Forskere: Michael Dyrgård Lundov, cand.scient, ph.d. Peter Rassing Andersen Marianne Hald, cand.med, ph.d Nikita Wu Forskningsmedarbejdere: Forskningsassistenter: Pao Lung-Tsai, cand.mag., IT-specialist Sara Fransson Jens Tranholm Olesen, cand.polyt., IT-specialist Ask Kvisselgard Anne-Marie Topp, forskningssygeplejerske Ida Skovgaard Katia Winter Oreskov, stud.med. Presa Mohammadzadeh, stud.med. Prægraduat forskningsårstuderende Victor Gjerding Bechmann Teknisk assistance: Malene Pravsgaard Christensen Susanne Schweitz, Sekretær Maria Gohr Anette Toe Hansen Videncenter for Frisører og Kosmetikere Zina Kheder Ulrik Fischer Friis, cand. polyt. ph.d., projektleder Sanne Steensgaard Ph.D. studerende Majken Gabriel Hougaard, cand.med. Forskningssygeplejerske: Christina Monnerup Damving, klinisk projektkoordi- Sanne Skovvang Steengaard, cand. scient. nator Teknisk og administrativt personale Klinik for hudsygdomme Iris Wintherstein, projektkoordinator Lone Skov, professor, overlæge, dr.med., ph.d., Amir Hazrati, Data- og Quality manager forskningsansvarlig overlæge Scott Hansen, laborant Shahin Aghazadeh, bioanalytiker Forskningsansvarlig sygeplejerske Adriana Sørensen, bioanalytiker Gitte Harboe, forskningsansvarlig sygeplejerske Katrine Vegener, laborant Trine Blom Andersen, laborant-studerende Seniorforskere: Jacob P. Thyssen, MD dr. med. ph.d. Videncenter for Allergi Peter Jensen. MD Ph.d. Jeanne Duus Johansen, Professor, dr.med., forsk- Nannie Bangsgaard, MD ph.d. ningschef 21 Ph.d. studerende: 10. Chawes BL, Govoni M, Piccinno A, Kreiner-Møller E, Vissing NH, Mortensen L et al. A clinical pharmacology study of fixed vs. free combination of inhaled beclometasone dipropionate and formoterol fumarate dry powder inhalers in asthmatic adolescents. British journal of clinical pharmacology. 2014 nov;78(5):1169-71. Tilgængelig fra: 10.1111/bcp.1242 Marianne B. Løvendorf, cand.scient. Beatrice Dyring-Andersen, cand. med. Mette Gyldenløve, cand. med. 11. Chawes BL, Bønnelykke K, Jensen PF, Schoos A-MM, Heickendorff L, Bisgaard H. Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study. P L o S One. 2014;9(6):e99856. Tilgængelig fra: 10.1371/journal.pone.0099856 Stine Simonsen, cand. med. Kristiane Engebretsen, cand. med. Ann Sophie Lønnborg, cand. med. 12. Chawes BL, Govoni M, Kreiner-Møller E, Vissing NH, Poorisrisak P, Mortensen L et al. Systemic exposure to inhaled beclometasone/formoterol DPI is age and body size dependent. Respiratory Medicine. 2014 aug;108(8):1108-16. Tilgængelig fra: 10.1016/j.rmed.2014.05.007 Forskningsassistenter: Mie Mogensen, bioanalytiker 13. Damsgaard N, Hajari J, Heegaard S, Skov L. Månedens billede. Ugeskrift for læger [online]. 2014 maj 12;176(10). Anni Olsen, bioanalytiker Nina B. Jørgensen, projektsygeplejerske 14. Dantoft TM, Elberling J, Brix S, Szecsi PB, Vesterhauge S, Skovbjerg S. An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. Psychoneuroendocrinology. 2014 feb;40:140-50. Tilgængelig fra: 10.1016/j.psyneuen.2013.11.012 Lina Rouyouf Khoury, stud. scient. san. Prægraduat forskningsstudent: 15. Dyring Andersen B, Geisler C, Aggerbeck C, Lauritsen JPH, Gúdjonsdottir SD, Skov L et al. Increased number and frequency of group 3 innate lymphoid cells in non-lesional psoriatic skin. British Journal of Dermatology. 2014 mar;170(3):609616. Tilgængelig fra: 10.1111/bjd.12658 Raja Sikandar Aziz, stud med. Professorer i 2014: 16. Elberling J, Bonde JPE, Vesterhauge S, Bang SH, Linneberg A, Zachariae C et al. A new classification code is available in the Danish health-care classification system for patients with symptoms related to chemicals and scents. Ugeskrift for læger [online]. 2014 maj 26;176(11):176. Hans Bisgaard Jeanne Duus Johansen Lars K. Poulsen Lone Skov 17. Elberling J, Arendt-Nielsen L. Transmission og modulation af kløe. Ugeskrift for læger [online]. 2014 aug 4;176(32). Publikationer 2014 18. Elberling J, Wulf HCO. treatment of Lentigo Maligna in Dark Skin with topical Imiquimod Results in Dark Hyperpigmentation. International Journal of Dermatology. 2014;19-20. 1. 2. Ahlehoff O, Skov L, Gislason G, Gniadecki R, Iversen L, Bryld LE et al. Cardiovascular outcomes and systemic anti-inflammatory drugs in patients with severe psoriasis: 5-year follow-up of a Danish nationwide cohort. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014 okt 10. Tilgængelig fra: 10.1111/jdv.12768 19. Elmose C, Sverrild A, van der Sluis S, Kyvik KO, Backer V, Thomsen SF. Genetic factors explain half of all variance in serum eosinophil cationic protein. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2014 dec 29;44(12):1525–1530. Tilgængelig fra: 10.1111/cea.12445 Andersen RMO, Zachariae C, Johansen JD. Aluminium allergy and granulomas induced by vaccinations for children. Ugeskrift for læger [online]. 2014 mar 17;176(12A). Bandier J, Johansen JD, Petersen LJ, Carlsen BC. Skin pH, atopic dermatitis, and filaggrin mutations. Dermatitis. 2014 maj 14;25(3):127-9. Tilgængelig fra: 10.1097/DER.0000000000000045 20. Fage SW, Faurschou A, Thyssen JP. Copper hypersensitivity. Contact Dermatitis. 2014 okt;71(4):191-201. Tilgængelig fra: 10.1111/cod.12273 4. Bisgaard H, Bønnelykke K, Stokholm J. Immune-mediated diseases and microbial exposure in early life. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2014 apr;44(4):47581. Tilgængelig fra: 10.1111/cea.12291 22. Ferløv Schwensen J, Menné T, Veien NK, Funding AT, Avnstorp C, Osterballe M et al. Occupational contact dermatitis in blue-collar workers: results from a multicentre study from the Danish Contact Dermatitis Group (2003-2012). Contact Dermatitis. 2014 dec 18;71(6):348-355. Tilgængelig fra: 10.1111/cod.12277 5. Bregnbak D, Thyssen JP, Zachariae C, Johansen JD. Characteristics of chromium-allergic dermatitis patients prior to regulatory intervention for chromium in leather: a questionnaire study. Contact Dermatitis. 2014 dec;71(6):338-347. Tilgængelig fra: 10.1111/cod.12291 23. Ferløv Schwensen J, Menné T, Andersen KE, Sommerlund M, Johansen JD. Occupations at risk of developing contact allergy to isothiazolinones in Danish contact dermatitis patients: results from a Danish multicentre study (2009-2012). Contact Dermatitis. 2014 aug 21;71(5):295-302. Tilgængelig fra: 10.1111/cod.12286 6. Bregnbak D, Friis UF, Zachariae C, Menné T, Johansen JD. Protein contact dermatitis caused by worms and insects used to feed exotic birds. Contact Dermatitis. 2014 jan;70(1):64-6. Tilgængelig fra: 10.1111/cod.12142 7. Bruze M, Isaksson M, Gruvberger B, Andersen KE, Gonçalo M, Goossens A et al. Patch testing with methylchloroisothiazolinone/methylisothiazolinone 200 ppm aq. detects significantly more contact allergy than 100 ppm. A multicentre study within the European Environmental and Contact Dermatitis Research Group. Contact Dermatitis. 2014 jul;71(1):31-4. Tilgængelig fra: 10.1111/cod.12241 24. Ferløv Schwensen J, Menné T, Johansen JD. The combined diagnosis of allergic and irritant contact dermatitis in a retrospective cohort of 1000 consecutive patients with occupational contact dermatitis. Contact Dermatitis. 2014 aug 7;71(6):356– 363. Tilgængelig fra: 10.1111/cod.12288 3. 8. 9. 21. Ferløv Schwensen J, Bulut M, Nordholm-Carstensen A. Laparoscopy can be used to diagnose peritoneal tuberculosis. Ugeskrift for læger [online]. 2014 sep 22;176(39). 25. Friis UF, Dahlin J, Bruze M, Menné T, Johansen JD. Hidden exposure to formaldehyde in a swab caused allergic contact dermatitis. Contact Dermatitis. 2014 apr;70(4):258-60. Tilgængelig fra: 10.1111/cod.12172 26. Friis UF, Menné T, Flyvholm M-A, Bonde JPE, Lepoittevin J-P, Le Coz CJ et al. Isothiazolinones in commercial products at Danish workplaces. Contact Dermatitis. 2014 aug;71(2):65-74. Tilgængelig fra: 10.1111/cod.12235 Bråred Christensson J, Andersen KE, Bruze M, Johansen JD, Garcia-Bravo B, Gimenez Arnau A et al. Positive patch test reactions to oxidized limonene: exposure and relevance. Contact Dermatitis. 2014 aug 7;71(5):264272. Tilgængelig fra: 10.1111/cod.12285 27. Friis UF, Menné T, Schwensen JF, Flyvholm M-A, Bonde JPE, Johansen JD. Occupational irritant contact dermatitis diagnosed by analysis of contact irritants and allergens in the work environment. Contact Dermatitis. 2014 okt 10;71(6):364370. Tilgængelig fra: 10.1111/cod.12290 Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nature Genetics. 2014 jan;46(1):51-5. Tilgængelig fra: 10.1038/ng.283 28. Gallo J, Vaculova J, Goodman SB, Konttinen YT, Thyssen JP. Contributions of human tissue analysis to understanding the mechanisms of loosening and osteolysis in total hip replacement. Acta Biomaterialia. 2014 jun;10(6):2354-66. Tilgængelig fra: 10.1016/j.actbio.2014.02.003 29. Gether L, Thyssen JP, Avnstorp C. 'Allergyapp'--a novel app(lication) to detect contact allergens in cosmetic products. Contact Dermatitis. 2014 dec;71(6):379-81. Tilgængelig fra: 10.1111/cod.12309 22 30. Govoni M, Piccinno A, Lucci G, Poli G, Acerbi D, Baronio R et al. The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size. Pulmonary Pharmacology and Therapeutics. 2014 apr 16;30:102-109. Tilgængelig fra: 10.1016/j.pupt.2014.04.003 49. Høybye Bosteen M, Tritsaris K, Hansen AJ, Dissing S. IL-17A potentiates TNFαinduced secretion from human endothelial cells and alters barrier functions controlling neutrophils rights of passage. Pflügers Archiv : European journal of physiology. 2014 maj;466(5):961-72. Tilgængelig fra: 10.1007/s00424-013-1354-5 31. Grunnet M, Christensen IJ, Lassen U, Jensen LH, Lydolph M, Lund IK et al. Prognostic significance of circulating intact and cleaved forms of urokinase plasminogen activator receptor in inoperable chemotherapy treated cholangiocarcinoma patients. Clinical biochemistry. 2014 feb 12;47(7-8):599-604. Tilgængelig fra: 10.1016/j.clinbiochem.2014.01.030 50. Isaksson M, Andersen KE, Gonçalo M, Goossens A, Gruvberger B, Johansen JD et al. Multicentre patch testing with methylisothiazolinone by the European Environmental and Contact Dermatitis Research Group. Contact Dermatitis. 2014 maj;70(5):317-20. Tilgængelig fra: 10.1111/cod.12220 51. Jakobsen SS, Lidén C, Søballe K, Johansen JD, Menné T, Lundgren L et al. Failure of total hip implants: metals and metal release in 52 cases. Contact Dermatitis. 2014 jul 18;48(12). Tilgængelig fra: 10.1111/cod.12275 32. Grønhøj Larsen C, Gyldenløve M, Jensen DH, Therkildsen MH, Kiss K, Norrild B et al. Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review. B J C. 2014 mar 18;110(6):1587-94. Tilgængelig fra: 10.1038/bjc.2014.42 52. Jensen P, Zachariae C, Christensen R, Geiker NRW, Schaadt BK, Stender S et al. Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis. Acta Dermatovenereologica. 2014 feb 20;94(6):691-4. Tilgængelig fra: 10.2340/00015555-1824 33. Grønhøj Larsen C, Brandt B. Traumatic oesophageal perforation due to haematoma. International Journal of Surgery Case Reports. 2014;5(10):659-61. Tilgængelig fra: 10.1016/j.ijscr.2014.04.008 53. Jensen BM, Falkencrone S, Skov PS. Measuring histamine and cytokine release from basophils and mast cells. Methods in molecular biology (Clifton, N.J.). 2014;1192:135-45. Tilgængelig fra: 10.1007/978-1-4939-1173-8_10 34. Gustafson K, Jakobsen SS, Lorenzen ND, Thyssen JP, Johansen JD, Bonefeld CM et al. Metal release and metal allergy after total hip replacement with resurfacing versus conventional hybrid prosthesis. Acta Orthopaedica (Print Edition). 2014 aug;85(4):348-54. Tilgængelig fra: 10.3109/17453674.2014.922730 54. Jensen BM, Frandsen P, Raaby EMN, Oluf Schiøtz P, Skov PS, Poulsen LK. Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells. Journal of Leukocyte Biology. 2014 feb 3;95(6):893-901. Tilgængelig fra: 10.1189/jlb.0712354 35. Gyldenløve M, Menné T, Thyssen JP. Eucalyptus contact allergy. Contact Dermatitis. 2014 nov;71(5):303-4. Tilgængelig fra: 10.1111/cod.12268 55. Jensen P, Hamann D, Hamann CR, Jellesen MS, Jacob SE, Thyssen JP. Nickel and cobalt release from children's toys purchased in Denmark and the United States. Dermatitis. 2014 nov 11;25(6):356-65. Tilgængelig fra: 10.1097/DER.0000000000000084 36. Gyldenløve M, Tvede N, Larsen JL, Jacobsen S, Thyssen JP. Low prevalence of positive skin pathergy testing in Danish patients with Behçet's disease. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014;28(2):259-60. Tilgængelig fra: 10.1111/jdv.12189 56. Joensen UN, Jørgensen N, Meldgaard M, Frederiksen H, Andersson A-M, Menné T et al. Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men. Environmental Health Perspectives. 2014 apr;122(4):345-350. Tilgængelig fra: 10.1289/ehp.1306720 37. Gyldenløve M, Bjergager M. Månedens billede. Ugeskrift for læger [online]. 2014 sep 1;176(36). 38. Gyldenløve M, Bjerager M. Månedens billede. Ugeskrift for Laeger. 2014;176(18):1689. 57. Khalid U, Ahlehoff O, Gislason GH, Kristensen SL, Skov L, Torp-Pedersen C et al. Psoriasis and risk of heart failure: a nationwide cohort study. European Journal of Heart Failure. 2014 jul;16(7):743-8. Tilgængelig fra: 10.1002/ejhf.113 39. Gyldenløve M, Jensen P, Linneberg A, Thyssen JP, Zachariae C, Hansen PR et al. Psoriasis and the Framingham risk score in a Danish hospital cohort. International Journal of Dermatology. 2014 sep;53(9). Tilgængelig fra: 10.1111/ijd.12196 58. Kimber I, Basketter DA, Thyssen JP, Dearman RJ, McFadden JP. Chemical allergy in humans: Fresh perspectives. Journal of Immunotoxicology. 2014 sep 25;11(3):203204. Tilgængelig fra: 10.3109/1547691X.2013.833661 40. Gyldenløve M, Rørvig S, Skov L, Hansen D. Severe hypercalcaemia, nephrocalcinosis, and multiple paraffinomas caused by paraffin oil injections in a young bodybuilder. Lancet. 2014 jun 14;383(9934):2098. Tilgængelig fra: 10.1016/S0140-6736(14)60806-0 59. Kofoed K, Norrbom C, Forslund O, Møller C, Frøding LP, Pedersen AE et al. Low Prevalence of Oral and Nasal Human Papillomavirus in Employees Performing CO2-laser Evaporation of Genital Warts or Loop Electrode Excision Procedure of Cervical Dysplasia. Acta Dermatovenereologica. 2015 jan 15;95(2):173-176. Tilgængelig fra: 10.2340/00015555-1912 41. Gyldenløve M, Jensen P, Løvendorf MB, Zachariae C, Hansen PR, Skov L. 'Short-term treatment with methotrexate does not affect microvascular endothelial function in patients with psoriasis'. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014 feb 21;1-4. Tilgængelig fra: 10.1111/jdv.12385 60. Kofoed K, Sand C, Forslund O, Madsen K. Prevalence of Human Papillomavirus in Anal and Oral Sites Among Patients with Genital Warts. Acta Dermatovenereologica. 2014 mar;94(2):207-211. Tilgængelig fra: 10.2340/00015555-1718 42. Hamann D, Yazar K, Hamann CR, Thyssen JP, Lidén C. p-Phenylenediamine and other allergens in hair dye products in the United States: a consumer exposure study. Contact Dermatitis. 2014 apr;70(4):213-8. Tilgængelig fra: 10.1111/cod.12164 61. Kreiner-Møller E, Bisgaard H, Bønnelykke K. Prenatal and postnatal genetic influence on lung function development. The Journal of allergy and clinical immunology. 2014 nov;134(5):1036-42.e15. Tilgængelig fra: 10.1016/j.jaci.2014.04.003 62. Kaae J, Szecsi PB, Meldgaard M, Espersen MLM, Stender S, Johansen JD et al. Individuals with complete filaggrin deficiency may have an increased risk of squamous cell carcinoma. British Journal of Dermatology. 2014 jun;170(6):1380-1. Tilgængelig fra: 10.1111/bjd.12911 43. Harder E, Andersen A-MN, Kamper-Jørgensen M, Skov L. No increased risk of fetal death or prolonged time to pregnancy in women with psoriasis. The Journal of investigative dermatology. 2014 jun;134(6):1747-9. Tilgængelig fra: 10.1038/jid.2014.35 63. Larsen JM, Brix S, Thysen AH, Birch S, Rasmussen MA, Bisgaard H. Children with asthma by school age display aberrant immune responses to pathogenic airway bacteria as infants. The Journal of allergy and clinical immunology. 2014 apr;133(4):1008-1013.e4. Tilgængelig fra: 10.1016/j.jaci.2014.01.010 44. Heisterberg MV, Menné T, Johansen JD. Fragrance allergy and quality of life development and validation of a disease-specific quality of life instrument. Contact Dermatitis. 2014 feb;70(2):69-80. Tilgængelig fra: 10.1111/cod.12153 45. Heisterberg MV, Menné T, Johansen JD. Fragrance allergy and quality of life - a case-control study. Contact Dermatitis. 2014 feb;70(2):81-9. Tilgængelig fra: 10.1111/cod.12128 64. Lindsted G, Larsen R, Krøigaard M, Garvey LH, Poulsen LK, Mosbech H et al. Transfusion-associated anaphylaxis during anaesthesia and surgery--a retrospective study. Vox Sanguinis. 2014 aug;107(2):158-65. Tilgængelig fra: 10.1111/vox.12133 46. Hjortø S, Skov L, Lykke JA. Obstetric dermatoses. Ugeskrift for læger [online]. 2014 sep 29;176(40). 65. Lundov MD, Kolarik B, Bossi R, Gunnarsen L, Johansen JD. Emission of isothiazolinones from water-based paints. Environmental Science and Technology. 2014 jun 17;48(12):6989-94. Tilgængelig fra: 10.1021/es500236m 47. Hougaard MG, Johansen JD, Linneberg A, Bandier J, Stender S, Carlsen BC et al. Skin prick test reactivity to aeroallergens by filaggrin mutation status. European Academy of Dermatology and Venereology. Journal. 2014;28(14):238– 241. Tilgængelig fra: 10.1111/j.1468-3083.2012.04679.x 66. Lysdal SH, Mosbech H, Johansen JD, Søsted H. Asthma and respiratory symptoms among hairdressers in Denmark: Results from a register based questionnaire study. American Journal of Industrial Medicine. 2014 dec;57(12):1368-76. Tilgængelig fra: 10.1002/ajim.22390 48. Husemoen LLN, Skaaby T, Martinussen T, Jørgensen T, Thuesen BH, Kistorp C et al. Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach. European journal of clinical nutrition. 2014 feb;68:189-95. Tilgængelig fra: 10.1038/ejcn.2013.233 67. Lønnberg AS, Zachariae C, Skov L. Targeting of interleukin-17 in the treatment of psoriasis. Clinical. Cosmetic and Investigational Dermatology. 2014;7:251-9. Tilgængelig fra: 10.2147/CCID.S67534 23 68. Løvendorf MB, Zibert JR, Gyldenløve M, Røpke MA, Skov L. MicroRNA-223 and miR-143 are important systemic biomarkers for disease activity in psoriasis. Journal of Dermatological Science. 2014 aug;75(2):133-9. Tilgængelig fra: 10.1016/j.jdermsci.2014.05.00 87. Schalock PC, Thyssen JP. Metal hypersensitivity reactions to implants: opinions and practices of patch testing dermatologists. Dermatitis. 2014;24(6):313-20. Tilgængelig fra: 10.1097/DER.0b013e3182a67d90 69. Malling H-J, Hansen KS, Garvey LH. Anafylaksi. Ugeskrift for læger [online]. 2014 maj 26;176(22):2-6. 88. Schmidt JD, Johansen JD, Nielsen MM, Zimersson E, Svedman C, Bruze M et al. Immune responses to hair dyes containing toluene-2,5-diamine. British Journal of Dermatology. 2014 feb;170(2):352-359. Tilgængelig fra: 10.1111/bjd.12676 70. Marstrand T, Ahler CB, Ralfkiaer U, Clemmensen A, Kopp KL, Sibbesen NA et al. Validation of a diagnostic microRNA classifier in cutaneous T-cell lymphomas. Clinical Lymphoma, Myeloma & Leukemia. 2014 apr;55(4):957-958. Tilgængelig fra: 10.3109/10428194.2013.815352 89. Schwensen JF, Johansen JD, Veien NK, Funding AT, Avnstorp C, Osterballe M et al. Occupational contact dermatitis in hairdressers: an analysis of patch test data from the Danish contact dermatitis group, 2002-2011. Contact Dermatitis. 2014 apr;70(4):233-7. Tilgængelig fra: 10.1111/cod.12176 71. Menné Bonefeld C, Nielsen MM, Gimenéz-Arnau E, Lang M, Vennegaard MT, Geisler C et al. An immune response study of oakmoss absolute and its constituents atranol and chloroatranol. Contact Dermatitis. 2014 maj;70(5):282-90. Tilgængelig fra: 10.1111/cod.12177 90. Simonsen AB, Deleuran M, Mortz CG, Johansen JD, Sommerlund M. Allergic contact dermatitis in Danish children referred for patch testing - a nationwide multicentre study. Contact Dermatitis. 2014 feb;70(2):104-111. Tilgængelig fra: 10.1111/cod.12129 72. Michaelsen SH, Larsen CG, von Buchwald C. Human papillomavirus shows highly variable prevalence in esophageal squamous cell carcinoma and no significant correlation to p16INK4a overexpression: a systematic review. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2014 jun;9(6):865-71. Tilgængelig fra: 10.1097/JTO.0000000000000166 91. Skaaby T, Husemoen LLN, Jørgensen T, Johansen JD, Menné T, Szecsi PB et al. Associations of Filaggrin Gene Loss-of-Function Variants and Human Papillomavirus-Related Cancer and Pre-Cancer in Danish Adults. P L o S One. 2014;9(6):e99437. Tilgængelig fra: 10.1371/journal.pone.0099437 92. Skaaby T, Husemoen LLN, Thyssen JP, Meldgaard M, Thuesen BH, Pisinger C et al. Filaggrin loss-of-function mutations and incident cancer: A population-based study. British Journal of Dermatology. 2014 mar 14;171(6):1407-14. Tilgængelig fra: 10.1111/bjd.12969 73. Mollerup A, Veien NK, Johansen JD. An analysis of gender differences in patients with hand eczema - everyday exposures, severity, and consequences. Contact Dermatitis. 2014 jul;71(1):21-30. Tilgængelig fra: 10.1111/cod.12206 93. Sonnenschein-van der Voort AMM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H et al. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. The Journal of allergy and clinical immunology. 2014 maj;133(5):1317-29. 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Contact Dermatitis. 2014 jul;71(1):49-53. Tilgængelig fra: 10.1111/cod.12228 103. Thyssen JP, McFadden JP, Kimber I. The multiple factors affecting the association between atopic dermatitis and contact sensitization. Allergy. 2014 jan;69(1):28-36. Tilgængelig fra: 10.1111/all.12358 85. Ryberg K, Agner T, Andersen KE, Bircher A, Diepgen T, Foti C et al. Patch testing with a textile dye mix - a multicentre study. Contact Dermatitis. 2014 okt;71(4):215-23. Tilgængelig fra: 10.1111/cod.12244 104. Thyssen JP, Vester L, Grønhøj Larsen C, Smidt K, Jakobsen P, Hansen SH et al. The single-dose pharmacokinetics of Alitretinoin and its metabolites are not significantly altered in patients with cirrhosis. British Journal of Dermatology. 2014 feb;170(2):408-14. Tilgængelig fra: 10.1111/bjd.12546 86. Saetterstrøm B, Olsen J, Johansen JD. Cost-of-illness of patients with contact dermatitis in Denmark. Contact Dermatitis. 2014 sep;71(3):154-61. Tilgængelig fra: 10.1111/cod.12231 105. Thyssen JP, Laursen ASD, Husemoen LLN, Stender S, Szecsi PB, Menné T et al. Variants in caspase-14 gene as risk factors for xerosis and atopic dermatitis. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014 nov 30. Tilgængelig fra: 10.1111/jdv.12821 24 106. Tran MTD, Skovbjerg S, Arendt-Nielsen L, Bech P, Lunde MA, Elberling J. Two of three patients with multiple chemical sensitivity had less symptoms and secondary hyperalgesia aftert ranscranially applied pulsed electromagnetic fields. Scandinavian Journal of Pain. 2014;5:104-109. 107. van der Valk RJP, Duijts L, Timpson NJ, Salam MT, Standl M, Curtin JA et al. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. The Journal of allergy and clinical immunology. 2014 jul;134(1):46-55. Tilgængelig fra: 10.1016/j.jaci.2013.08.053 108. van Ree R, Hummelshøj L, Plantinga M, Poulsen LK, Swindle E. Allergic sensitization: host-immune factors. 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Innate lymphoid cells and gamma delta T cells in inflammatory skin disease: A study of prevalence and phenotype in psoriasis and contact allergy. 2014. 97 s. 113. Friis UF. Exposure assessment in occupational contact dermatitis. 1 udg. Videncenter for Allergi: Gentofte Universitetshospital, 2014. 105 s. 114. Kreiner-Møller E. A genetic approach to understanding asthma and lung function development. 2014. 115. Løvendorf MB. MicroRNAs as Biomarkers in Psoriasis. 2014. 78 s. 116. Mollerup A. Hand eczema Self Management and prognosis: Self Management and prognosis. 2014. 113 s. 117. Thysen AH. Perinatal Environmental Effects on the Neonatal Immune System. 2014. 118 s. 118. Tran MTD. Central sensitization in multiple chemical sensitivity: Quantitative sensory testing an therapeutic studies. 2014. 122 s. 119. Vissing NH. Neonatal Bacterial Colonization Predispose to Lower Respiratory Infections in Early Childhood. 2014. Konferenceabstrakt til konference 120. Jensen BM, Gohr M, Poulsen LK. Expression of the Transcription Factor E4BP4 in Human Basophils. 2014. 25 Klinisk Biokemisk afd. Forskningstemaer Tilstedeværelsen af transfedtsyrer i populære føde- 4. Baronaite R, Engelhart M, Mørk Hansen T, Thamsborg G, Slott Jensen H, Stender S et al. A comparison of anti-nuclear antibody quantification using automated enzyme immunoassays and immunofluorescence assays. Autoimmune Diseases. 2014;2014:534759. Tilgængelig fra: 10.1155/2014/534759 5. Benn M. Statinbehandling og udvikling af diabetes mellitus. Ugeskrift for Laeger.2014 feb 3;176(3):218. 6. Bladbjerg E-M, Larsen TM, Due A, Jespersen J, Stender S, Astrup A. Postprandial coagulation activation in overweight individuals after weight loss: acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet. Thrombosis Research. 2014 mar;133(3):327-33. Tilgængelig fra: 10.1016/j.thromres.2013.12.010 7. Damsgaard CT, Eidner MB, Stark KD, Hjorth MF, Sjödin A, Andersen MR et al. Eicosapentaenoic acid and docosahexaenoic acid in whole blood are differentially and sex-specifically associated with cardiometabolic risk markers in 8-11-yearold danish children. P L o S One. 2014;9(10):e109368. Tilgængelig fra: 10.1371/journal.pone.0109368 8. Damsgaard CT, Dalskov S-M, Laursen R, Ritz C, Hjorth MF, Lauritzen L et al. Provision of healthy school meals does not affect the metabolic syndrome score in 8-11-year-old children, but reduces cardiometabolic risk markers despite increasing waist circumference. The British journal of nutrition. 2014 dec 14;112(11):1826-36. Tilgængelig fra: 10.1017/S0007114514003043 9. Dantoft TM, Elberling J, Brix S, Szecsi PB, Vesterhauge S, Skovbjerg S. An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. Psychoneuroendocrinology. 2014 feb;40:140-50. Tilgængelig fra: 10.1016/j.psyneuen.2013.11.012 varer i Europa Virkningen af omega-3 fedt på ikke fastende forhøjet triglycerid i plasma Forekomsten og betydningen af det hudtættende protein filaggrin Betydningen af den præanalytiske håndtering af blodprøverør for svartiden og det endelige analyseresultat Passiv rygning hos gravide og barnets fødselsvægt Mendelsk randomisering og risiko for diabetes og kardiovaskulær sygdom Kønshormoner, genetisk variation og risiko for kardiovaskulær sygdom Familiær hyperkolesterolæmi i den almindelige befolkning Implementeringsforskning vedr. eEKG og decentral glukosemåling på Gentofte Hospital Videnskabelige medarbejdere 10. Ebdrup BH, Knop FK, Madsen A, Mortensen HB, Søgaard B, Holst JJ et al. Glucometabolic hormones and cardiovascular risk markers in antipsychotictreated patients. Journal of Clinical Psychiatry. 2014 sep;75(9):e899-905. Tilgængelig fra: 10.4088/JCP.13m08820 Steen Stender, ledende overlæge, dr.med. Pal Szesci, overlæge, dr.med. 11. Frikke-Schmidt R, Tybjærg-Hansen A, Dyson G, Haase CL, Benn M, Nordestgaard BG et al. Subgroups at high risk for ischaemic heart disease-identification and validation in 67 000 individuals from the general population. International Journal of Epidemiology. 2014 okt 30;1-12. Tilgængelig fra: 10.1093/ije/dyu215 Klinisk forskningslektor og seniorforsker delestilling Marianne Benn, overlæge, dr. med, ph.d 12. Geiker N, Myint KS, Heck P, Dhatariya K, Hørup Larsen SM, Andersen MR et al. Intentional Weight Loss Improved Performance in Obese Ischaemic Heart Patient: A Two Centre Intervention Trial. Jacobs journal of food and nutrition. 2014;1(1). 003. Seniorforsker Sarah Caroline Wiesenfeldt Maroutt 13. Holmegard HN, Nordestgaard BG, Schnohr P, Tybjaerg-Hansen A, Benn M. Endogenous sex hormones and risk of venous thromboembolism in women and men. Journal of thrombosis and haemostasis : JTH. 2014;12(3):297-305. Tilgængelig fra: 10.1111/jth.12484 Andet forskningsaktivt personale 14. Hornnes N, Larsen K, Brink-Kjær T, Boysen G. Specific antismoking advice after stroke. Danish Medical Journal. 2014 apr;61(4). A4816. Haya Nicole Holmegard, farmaceut, ph.d Malene Rohr Andersen, projektkoordinator, ph.d. 15. Hougaard MG, Johansen JD, Linneberg A, Bandier J, Stender S, Carlsen BC et al. Skin prick test reactivity to aeroallergens by filaggrin mutation status. European Academy of Dermatology and Venereology. Journal. 2014;28(14):238–241. Tilgængelig fra: 10.1111/j.1468-3083.2012.04679.x Anne Hedengran Nedergaard, stud. med. Forskningsansvarlig overlæge 16. Husemoen LLN, Skaaby T, Martinussen T, Jørgensen T, Thuesen BH, Kistorp C et al. Investigating the causal effect of vitamin D on serum adiponectin using a mendelian randomization approach. European journal of clinical nutrition. 2014 feb;68:18995. Tilgængelig fra: 10.1038/ejcn.2013.233 Steen Stender, ledende overlæge, dr.med. Publikationer 2014 1. 17. Jensen P, Zachariae C, Christensen R, Geiker NRW, Schaadt BK, Stender S et al. Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis. Acta Dermatovenereologica. 2014 feb 20;94(6):691-4. Tilgængelig fra: 10.2340/00015555-1824 Aller EEJG, Larsen TM, Holst C, Lindroos AK, Kafatos A, Pfeiffer A et al. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12month results. International journal of obesity (2005). 2014 mar 28;38(12):1511-1517. Tilgængelig fra: 10.1038/ijo.2014.52 2. Amin FM, Hougaard A, Schytz HW, Asghar MS, Lundholm E, Parvaiz AI et al. Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38. Brain : a journal of neurology. 2014;137:779-94. Tilgængelig fra: 10.1093/brain/awt369 3. Astrup A, Larsen ML, Stender S, Dyerberg J. Fedtstoffernes betydning for forebyggelse af hjerte-kar-sygdom i Danmark. Ugeskrift for læger [online]. 2014 maj 5;176(19). 18. Joensen UN, Jørgensen N, Meldgaard M, Frederiksen H, Andersson A-M, Menné T et al. Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men. Environmental Health Perspectives. 2014 apr;122(4):345-350. Tilgængelig fra: 10.1289/ehp.1306720 19. Kaae J, Szecsi PB, Meldgaard M, Espersen MLM, Stender S, Johansen JD et al. Individuals with complete filaggrin deficiency may have an increased risk of squamous cell carcinoma. British Journal of Dermatology. 2014 jun;170(6):1380-1. Tilgængelig fra: 10.1111/bjd.12911 26 20. Marott SCW, Nielsen SF, Benn M, Nordestgaard BG. Antihypertensive treatment and risk of atrial fibrillation: a nationwide study. European Heart Journal. 2014;35(18):1205. Tilgængelig fra: 10.1093/eurheartj/eht507 21. Poulsen SK, Due A, Jordy AB, Kiens B, Stark KD, Stender S et al. Health effect of the New Nordic Diet in adults with increased waist circumference: a 6-mo randomized controlled trial. The American journal of clinical nutrition. 2014 jan;99(1):35-45. Tilgængelig fra: 10.3945/ajcn.113.069393 22. Sibilitz KL, Benn M, Nordestgaard BG. Creatinine, eGFR and association with myocardial infarction, ischemic heart disease and early death in the general population. Atherosclerosis. 2014 sep 3;237(1):67-75. Tilgængelig fra: 10.1016/j.atherosclerosis.2014.08.040 23. Skaaby T, Husemoen LLN, Jørgensen T, Johansen JD, Menné T, Szecsi PB et al. Associations of Filaggrin Gene Loss-of-Function Variants and Human Papillomavirus-Related Cancer and Pre-Cancer in Danish Adults. P L o S One. 2014;9(6):e99437. Tilgængelig fra: 10.1371/journal.pone.0099437 24. Skaaby T, Husemoen LLN, Thyssen JP, Meldgaard M, Thuesen BH, Pisinger C et al. Filaggrin loss-of-function mutations and incident cancer: A populationbased study. British Journal of Dermatology. 2014 mar 14;171(6):1407-14. Tilgængelig fra: 10.1111/bjd.12969 25. Stender S, Astrup A, Dyerberg J. Tracing artificial trans fat in popular foods in Europe: a market basket investigation. B M J Open. 2014;4(5):e005218. Tilgængelig fra: 10.1136/bmjopen-2014-005218 26. Szecsi PB, Andersen MR, Bjørngaard B, Hedengran KK, Stender S. Cancer antigen 125 after delivery in women with a normal pregnancy: a prospective cohort study. Acta Obstetricia et Gynecologica Scandinavica. 2014 dec;93(12):1295301. Tilgængelig fra: 10.1111/aogs.12492 27. Thyssen JP, Laursen ASD, Husemoen LLN, Stender S, Szecsi PB, Menné T et al. Variants in caspase-14 gene as risk factors for xerosis and atopic dermatitis. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014 nov 30. Tilgængelig fra: 10.1111/jdv.12821 28. Varbo A, Benn M, Nordestgaard BG. Remnant cholesterol as a cause of ischemic heart disease: Evidence, definition, measurement, atherogenicity, high risk patients, and present and future treatment. Pharmacology & Therapeutics. 2014 mar;141(3):358-67. Tilgængelig fra: 10.1016/j.pharmthera.2013.11.008 Kommentar/debat 29. Brøndum-Jacobsen P, Nordestgaard BG, Nielsen SF, Benn M. Authors' Response to: Skin cancer as a marker of sun exposure-a case of serious immortality bias. International Journal of Epidemiology. 2014 jun;43(3):972-3. Tilgængelig fra: 10.1093/ije/dyu102 30. Brøndum-Jacobsen P, Nordestgaard BG, Nielsen SF, Benn M. Authors' response to: skin cancer as a marker of sun exposure. International Journal of Epidemiology. 2014 dec;43(6):1992-3. Tilgængelig fra: 10.1093/ije/dyu211 31. Varbo A, Benn M, Tybjærg-Hansen A, Nordestgaard BG. Reply to letters regarding article, "Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation". Circulation (Baltimore). 2014 jun 17;129(24):e656. Tilgængelig fra: 10.1161/CIRCULATIONAHA.114.009348 Konferenceabstrakt i tidsskrift 32. Ebdrup BH, Knop FK, Madsen A, Mortensen HB, Søgaard B, Holst JJ et al. Glucometabolic Hormones and Cardiovascular Risk Markers in AntipsychoticTreated Patients. Schizophrenia Research. 2014 apr;153(Suppl. 1):90. 27 Lungemedicinsk afd. På Lungemedicinsk afdeling er der omfattende forsk- Forskningsansvarlig sygeplejerske ning Ingelise Trosborg, sygeplejerske, MVO indenfor screening for lungecancer, CT- kvantitering af emfysem, alfa1-antitrypsin mangel og rygeafvænning. Afdelingens forskning indenfor disse Publikationer 2014 områder på højt internationalt niveau. Der foregår 1. Armbruster K, Naqibullah M, Clementsen PF. Pleuracentese. Ugeskrift for læger [online]. 2014 maj 19;176(21). 2. Ashraf H, Saghir Z, Dirksen A, Pedersen JH, Thomsen LH, Døssing M et al. Smoking habits in the randomised Danish Lung Cancer Screening Trial with lowdose CT: final results after a 5-year screening programme. Thorax. 2014 jun;69(6):574-9. Tilgængelig fra: 10.1136/thoraxjnl-2013-203849 3. Bendixen HJ, Wæhrens EE, Wilcke JT, Sørensen LV. Self-reported quality of ADL task performance among patients with COPD exacerbations. Scandinavian Journal of Occupational Therapy. 2014 jul;21(4):313-20. Tilgængelig fra: 10.3109/11038128.2014.899621 4. Blauenfeldt T, Heyckendorf J, Graff Jensen S, Lange C, Drabe C, Hermansen TS et al. Development of a One-Step Probe Based Molecular Assay for Rapid Immunodiagnosis of Infection with M. tuberculosis Using Dried Blood Spots. P L o S One. 2014 sep 3;9(9):e105628. Tilgængelig fra: 10.1371/journal.pone.0105628 5. Brodersen J, Dirksen A, Pedersen JH. Screening for lung cancer with low-dose computed tomography. Annals of internal medicine. 2014 feb 4;160(3):212. Tilgængelig fra: 10.7326/L14-5003-2 6. Clementsen PF, Skov BG, Vilmann P, Krasnik M. Endobronchial ultrasoundguided biopsy performed under optimal conditions in patients with known or suspected lung cancer may render mediastinoscopy unnecessary. Journal of Bronchology & Interventional Pulmonology. 2014 jan;21(1):21-5. Tilgængelig fra: 10.1097/LBR.0000000000000028 7. Colella S, Vilmann P, Konge L, Clementsen PF. Endoscopic ultrasound in the diagnosis and staging of lung cancer. Endoscopic ultrasound. 2014 okt;3(4):20512. Tilgængelig fra: 10.4103/2303-9027.144510 8. Gottlieb M, Clementsen PF, Håkansson K, Petersen RH, Konge L. Uventet fund af endobronkial lungetumor ved bronkoskopi hos en storryger. Ugeskrift for læger [online]. 2014 nov 3;176(45):V05140262. 9. Jennum P, Tønnesen P. Obstruktiv søvnapnø-syndrom. Ugeskrift for læger [online]. 2014 maj 26;176(11). endvidere forskning i udredning af lungekræft (inklusiv screening med lav-dosis CT-scanning med særlig bevilling fra Finansloven). Afdelingen har det ordinære professorat i medicinske lungesygdomme for Københavns Universitet og endvidere en klinisk lektor. Forskningstemaer Rygeafvænning Udredning af patienter mistænkt for lungecancer Screening af rygere for lungecancer NIV ved KOL og obstruktiv søvnapnø Billeddiagnostik ved KOL Interstitielle lungesygdomme Astma Tuberkulose Behandling af alfa1-antitrypsin mangel Videnskabelige medarbejdere Professorer Asger Dirksen, overlæge, dr.med. Jørgen Vestbo, dr.med. Postdoc 10. Konradsen H, Lillebaek T, Wilcke JTR, Lomborg K. Being publicly diagnosed: A grounded theory study of Danish patients with tuberculosis. International Journal of Qualitative Studies on Health and Well-Being. 2014;9:1-8. Torgny Wilcke, overlæge, ph.d. Seniorforsker delestilling 11. Konradsen H, Trosborg I, Christensen L, Pedersen PU. Evaluation of interrater reliability assessing oral health in acute care settings. International Journal of Nursing Practice. 2014;20:258. Tilgængelig fra: 10.1111/ijn.12140 Paul F. Clementsen, overlæge, dr.med. 12. Konradsen H, Trosborg I, Christensen L, Thomsen T, Pedersen PU. Who needs oral care? A study of potential factors associated with the need for oral care. Journal of Nursing Education and Practice. 2014;4(11):16-22. Tilgængelig fra: http://dx.doi.org/10.5430/jnep.v4n11p16 Post.doc. delestilling Hanne Konradsen, sygeplejerske, cand.cur., ph.d. 13. Larsen SS, Vilmann P, Krasnik K, Dirksen A, Clementsen P, Skov BG et al. A comparison of endoscopic ultrasound guided biopsy and positron emission tomography with integrated computed tomography in lung cancer staging. Current health sciences journal. 2014 jan;35(1):5-12. Ph.d. studerende Zaigham Saghir, cand.med. Lone Skov Jensen, cand.cur. 14. Lock-Johansson S, Vestbo J, Sorensen G. Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease. Respiratory research. 2014 nov 25;15(1):147. Tilgængelig fra: 10.1186/s12931-014-0147-5 Laura Hohwü Thomsen, cand.med. Sidse Graff Jensen, cand.med. Kasper Ankjærgaard, cand.med. 15. Lundbäck B, Bakke P, Ingebrigtsen T, Lange P, Lindberg A, Soriano JB et al. Chronic obstructive pulmonary disease. Eur Respir Monograph. 2014;65:1-18. Mathilde Marie Winkler Wille, cand.med. 16. Løkke A, Hilberg O, Tønnesen P, Ibsen R, Kjellberg J, Jennum P. Direct and indirect economic and health consequences of COPD in Denmark: a national register-based study: 1998-2010. B M J Open. 2014;4(1):e004069. Tilgængelig fra: 10.1136/bmjopen-2013-004069 Andet forskningsaktivt personale Ca. 10 forskningssygeplejersker og sekretærer 17. Noiesen E, Trosborg I, Bager L, Herning M, Lyngby C, Konradsen H. Constipation - prevalence and incidence among medical patients acutely admitted to hospital with a medical condition. Journal of Clinical Nursing. 2014 aug 1;23(1516):2295-2302. Tilgængelig fra: 10.1111/jocn.12511 Forskningsansvarlig overlæge Asger Dirksen, professor, overlæge, dr.med. 28 18. Petersen J, Wille MMW, Rakêt LL, Feragen A, Pedersen JH, Nielsen M et al. Effect of inspiration on airway dimensions measured in maximal inspiration CT images of subjects without airflow limitation. European Radiology. 2014 sep;24(9):2319-25. Tilgængelig fra: 10.1007/s00330-014-3261-3 19. Petersen J, Nielsen M, Lo P, Nordenmark LH, Pedersen JH, Wille MMW et al. Optimal surface segmentation using flow lines to quantify airway abnormalities in chronic obstructive pulmonary disease. Medical Image Analysis. 2014 apr;18(3):531-41. Tilgængelig fra: 10.1016/j.media.2014.02.004 20. Rasmussen JF, Siersma V, Pedersen JH, Heleno B, Saghir Z, Brodersen J. Healthcare costs in the Danish randomised controlled lung cancer CTscreening trial: a registry study. Lung cancer (Amsterdam, Netherlands). 2014 mar;83(3):347-55. Tilgængelig fra: 10.1016/j.lungcan.2013.12.005 21. Ringbaek TJ, Seersholm N, Perch M, Iversen M, Lange P. Prognosis of patients with alpha1-antitrypsine deficiency on long-term oxygen therapy. Respiratory Medicine. 2014 aug;108(8):1189-94. Tilgængelig fra: 10.1016/j.rmed.2014.05.001 22. Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF et al. Screening for lungecancer med lavdosis-CT - danske og udenlandske resultater. Ugeskrift for læger [online]. 2014 okt 13;176(42):V05140283. 23. Savran MM, Clementsen PF, Annema JT, Minddal V, Larsen KR, Park YS et al. Development and validation of a theoretical test in endosonography for pulmonary diseases. Respiration; international review of thoracic diseases. 2014;88(1):67-73. Tilgængelig fra: 10.1159/000362884 24. Sommer MS, Trier K, Vibe-Petersen J, Missel M, Christensen M, Larsen KR et al. Perioperative rehabilitation in operation for lung cancer (PROLUCA) - rationale and design. B M C Cancer. 2014;14. 404. Tilgængelig fra: 10.1186/1471-2407-14-404 25. Suzuki M, Makita H, Östling J, Thomsen LH, Konno S, Nagai K et al. Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease. Annals of the American Thoracic Society. 2014 dec;11(10):1511-9. Tilgængelig fra: 10.1513/AnnalsATS.201408-351OC 26. Thomsen LH, Dirksen A, Shaker SB, Skovgaard LT, Dahlbäck M, Pedersen JH. Analysis of FEV1 decline in relatively healthy heavy smokers: implications of expressing changes in FEV1 in relative terms. COPD. 2014 feb;11(1):96-104. Tilgængelig fra: 10.3109/15412555.2013.830096 27. Tønnesen P. E-cigaretten: et middel til rygestop uden support?. Ugeskrift for læger [online]. 2014 sep 1;176(36). 28. Vestbo J. Chronic bronchitis: so much more than just a smoker's cough. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2014 jul;18(7):760. Tilgængelig fra: 10.5588/ijtld.14.0357 29. Vestbo J, Celli B. Chronic obstructive pulmonary disease: different risk factors and different natural histories?. American journal of respiratory and critical care medicine. 2014 nov 1;190(9):968-70. Tilgængelig fra: 10.1164/rccm.2014091705ED 30. Wille MMW, Thomsen LH, Dirksen A, Petersen J, Pedersen JH, Shaker SB. Emphysema progression is visually detectable in low-dose CT in continuous but not in former smokers. European Radiology. 2014 nov;24(11):2692-9. Tilgængelig fra: 10.1007/s00330-014-3294-7 31. Willendrup F, Bodtger U, Colella S, Rasmussen D, Clementsen PF. Diagnostic accuracy and safety of semirigid thoracoscopy in exudative pleural effusions in Denmark. Journal of Bronchology & Interventional Pulmonology. 2014 jul;21(3):215-9. Tilgængelig fra: 10.1097/LBR.0000000000000088 Ph.d.-afhandling 32. Rasmussen T. Coronary Artery Calcification in Current and Former Smokers Assessed with Multi-detector Computed Tomography (Ph.d.-afhandling): Relation to Lung Function and Prognostic Value in Lung Cancer Screening. København: Eget forlag Københavns University, 2014. 57 s. 29 Medicinsk afd. C Forskningstemaer Validering af kliniske sygdomsmarkører og outcome measures på individ-niveau indenfor Sammenhæng mellemvestibulær dysfunktion og søvnapnø reumatologien Biokemiske markører og billeddiagnostiske Intial ortostatisk hypotension hos patienter med vestibulær dysfunktion undersøgelser (MR, CT, ultralyd) til diagnosti- Databaseforskning indenfor geriatri cering, monitorering og prognosticering af in- Sygeplejerske-telefonkonsultationer med reuma- flammatoriske ryg- og ledsygdomme tologiske patienter Kardiovaskulære risikofaktorer hos patienter med reumatoid artrit (PET-CT mv.) Videnskabelige medarbejdere Risiko for urinvejsinfektioner og værdi af Seniorforsker delestilling screening ved biologisk behandling af inflam- Ole Rintek Madsen, overlæge, dr.med. matorisk ledsygdom Lene Dreyer, overlæge, ph.d. Prognostiske faktorer ved psoriasisgigt Databaseforskning indenfor sklerodermi, SLE, Ph.d. studerende artrit Carrinna Hansen, klinisk udviklingssygeplejerske Sjældne bivirkninger ved behandling med biologisk medicin herunder cancer og demyelini- Andet forskningsaktivt personale serende sygdomme Jan Pødenphant, overlæge, dr.med.. Steroidinduceret binyrebarkinsuficiens Merete Engelhart, overlæge, dr.med. Osteoporose og reumatopid artrit (FRAX) Annette Hansen, specialeansvarlig overlæge Patient-tilfredshedsundersøgelser, studier i Pia Nimann Kanegaard, overlæge optimale infusionsforløb og rationel klinisk Marianne Kirchhoff, overlæge ph.d. kontrol i forbindelse med biologisk behandling Kirsten Damgaard, led. overlæge, dr. med. Opsporing og intervention overfor faldpatien- Susanne Juhl Pedersen, læge, ph.d ter Bente Glintborg, reservelæge ph.d. Validering af måleredskaber for vurdering af Gunhild Bukh, afdelingssygeplejerske funktion hos patienter med vestibulær dys- Anne Villadsen, klinisk sygeplejespecialist funktion Anne-Marie Tetche Sweeney, sygeplejerske Rehabilitering af KOL indlagt med forværring i Rikke Terp, klinisk sygeplejespecialist KOL Carsten Juhl, forsknings- og udviklingsfysioterapeut Effekten af træning til patienter med diabetes Kasper Søndergaard, forsknings- og udviklingsfysio- Tværsektionelt ernæringsprojekt – geriatriske terapeut patienter i ernæringsmæssig risiko Isabella Rogon, fysioterapeut Register forskning – risikofaktorer for apoplekse recidiv hos ambulante apopleksipatien- Forskningsansvarlig overlæge: ter Ole Rintek Madsen, klinisk lektor, ph.d., dr.med. Træthed hos patienter med SLE og reumatoid artrit Forskningsansvarlig sygeplejerske ”Åbent ambulatorium” – patienter med ledde- Rikke Terp Sørensen, klinisk sygeplejespecialist gigt Anvendelsen af De Morton Mobility Index (DEMMI) i det tværsektorielle forløb Publikationer 2014 Validering af fysioterapeutiske målemetoder til 1. Agarwal D, Pineda S, Michailidou K, Herranz J, Pita G, Moreno LT et al. FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. B J C. 2014 feb 18;110(4):1088-100. Tilgængelig fra: 10.1038/bjc.2013.769 2. Andersen TR, Schmidt JF, Nielsen JJ, Randers MB, Sundstrup E, Jakobsen MD et al. Effect of football or strength training on functional ability and physical performance in untrained old men. Scandinavian journal of medicine & science in sports. 2014 aug;24 Suppl 1:76-85. Tilgængelig fra: 10.1111/sms.12245 patienter med nedsat balance og svimmelhed Søvn – undersøgelse af indlagte patienters søvnkvalitet og betydningen heraf – et forskningsprojekt på tværs af afdelinger Pårørende-deltagelse via Skype-samtaler Sammenhæng mellem aldersbetinget hørenedsættelse og vestbulær dysfunktion/balance 30 3. Axelsen MB, Eshed I, Duer A, Møller JM, Pedersen SJ, Østergaard M. Wholebody MRI assessment of disease activity and structural damage in rheumatoid arthritis: first step towards an MRI joint count. Rheumatology (Oxford, England). 2014 jan 3;845-53. Tilgængelig fra: 10.1093/rheumatology/ket425 4. Baronaite R, Engelhart M, Mørk Hansen T, Thamsborg G, Slott Jensen H, Stender S et al. A comparison of anti-nuclear antibody quantification using automated enzyme immunoassays and immunofluorescence assays. Autoimmune Diseases. 2014;2014:534759. Tilgængelig fra: 10.1155/2014/534759 5. 6. 7. 8. 9. 10. 11. 12. 13. Bernatsky S, Ramsey-Goldman R, Joseph L, Boivin J-F, Costenbader KH, Urowitz MB et al. Lymphoma risk in systemic lupus: effects of disease activity versus treatment. Annals of the Rheumatic Diseases. 2014;73:138-142. Tilgængelig fra: 10.1136/annrheumdis-2012-202099 Bukh G, Tommerup AMM, Madsen OR. Impact of healthcare design on patients' perception of a rheumatology outpatient infusion room: an interventional pilot study. Clinical rheumatology. 2014 apr 8. Tilgængelig fra: 10.1007/s10067-0142592-4 Cordtz R, Mellemkjær L, Glintborg B, Hetland ML, Dreyer L. Malignant progression of precancerous lesions of the uterine cervix following DMARD therapy in female arthritis patients. Arthritis & Rheumatology. 2014;66(Suppl. 11):S374-5. Egsmose EL, Birkvig M, Buhl T, Madsen OR. FRAX fracture risk in women with a recent fracture of the distal forearm: agreement between assessments with and without bone mineral density and impact of measurement side in the individual patient. Clinical rheumatology. 2014 maj 14. Tilgængelig fra: 10.1007/s10067-014-2640-0 Glintborg B, Gudbjornsson B, Steen Krogh N, Omerovic E, Manilo N, HollandFischer M et al. Impact of different infliximab dose regimens on treatment response and drug survival in 462 patients with psoriatic arthritis: results from the nationwide registries DANBIO and ICEBIO. Rheumatology (Oxford, England). 2014 nov;53(11):2100-9. Tilgængelig fra: 10.1093/rheumatology/keu252 Hansen C, Konradsen H, Abrahamsen B, Pedersen B. Women’s experiences of their osteoporosis diagnosis at the time of diagnosis and six months later: a Phenomenological-hermeneutic Study. International Journal of Qualitative Studies on Health and Well-Being. 2014;22438. Tilgængelig fra: doi.org/10.3402/qhw.v9.22438 19. Poggenborg RP, Wiell C, Bøyesen P, Boonen A, Bird P, Pedersen SJ et al. No overall damage progression despite persistent inflammation in adalimumab-treated psoriatic arthritis patients: results from an investigator-initiated 48-week comparative magnetic resonance imaging, computed tomography and radiography trial. Rheumatology (Oxford, England). 2014 apr;53(4):746-756. Tilgængelig fra: 10.1093/rheumatology/ket426 20. Poggenborg RP, Bird P, Boonen A, Wiell C, Pedersen SJ, Sørensen IJ et al. Pattern of bone erosion and bone proliferation in psoriatic arthritis hands: a highresolution computed tomography and radiography follow-up study during adalimumab therapy. Scandinavian Journal of Rheumatology. 2014;43(3):202-8. Tilgængelig fra: 10.3109/03009742.2013.835865 21. Poulsen MH, Frost M, Abrahamsen B, Brixen K, Walter S. Osteoporosis and prostate cancer: a cross-sectional study of Danish men with prostate cancer before androgen deprivation therapy. Scandinavian Journal of Urology and Nephrology. 2014 feb 19;48(4):350-355. Tilgængelig fra: 10.3109/21681805.2014.884160 22. Theibich A, Dreyer L, Magyari M, Locht H. Demyelinizing neurological disease after treatment with tumor necrosis factor alpha-inhibiting agents in a rheumatological outpatient clinic: description of six cases. Clinical rheumatology. 2014 maj;33(5):719-723. Tilgængelig fra: 10.1007/s10067-013-2419-8 23. Villadsen AØ, Toft M. Lupuspatienter forsker i egen sygdom. ReumaDebat. 2014 apr 1;April 2014:12-13. 24. Ørnbjerg LM, Østergaard M, Bøyesen P, Krogh NS, Thormann A, Tarp U et al. Which factors influence radiographic progression during treatment with tumor necrosis factor inhibitors in clinical practice?: Results from 930 patients with rheumatoid arthritis in the nationwide Danish DANBIO registry. Journal of Rheumatology. 2014 dec;41(12):2352-60. Tilgængelig fra: 10.3899/jrheum.131299 25. Østergaard M, Jacobsson LTH, Schaufelberger C, Hansen MS, Bijlsma JWJ, Dudek A et al. MRI assessment of early response to certolizumab pegol in rheumatoid arthritis: a randomised, double-blind, placebo-controlled phase IIIb study applying MRI at weeks 0, 1, 2, 4, 8 and 16. Annals of the Rheumatic Diseases. 2014 dec 15. Tilgængelig fra: 10.1136/annrheumdis-2014-206359 Konferenceabstrakt i tidsskrift Huynh TK, Ostergaard A, Egsmose C, Madsen OR. Preferences of patients and health professionals for route and frequency of administration of biologic agents in the treatment of rheumatoid arthritis. Patient Preference and Adherence. 2014;8:93-9. Tilgængelig fra: 10.2147/PPA.S55156 Højgaard P, Glintborg B, Hetland ML, Hansen TH, Nilsson C, Lage-Hansen PR et al. Association between tobacco smoking and response to tumor necrosis factor alpha inhibitor treatment in psoriatic arthritis: Results from the DANBIO registry. Annals of the Rheumatic Diseases. 2014;73(Suppl. 2):743. Jensen TW, Hansen MS, Hørslev-Petersen K, Hyldstrup L, Abrahamsen B, Langdahl BL et al. Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial. Annals of the Rheumatic Diseases. 2014 maj 9;73(6):1123-1129. Tilgængelig fra: 10.1136/annrheumdis-2012-203171 26. Askling J, Dreyer L, Hetland ML, Jacobsson L, Kristensen L-E, Glintborg B. Cancer incidence in TNF inhibitor treated patients with axial spondyloarthritis and psoriatic arthritis - a study from the ARTIS and Danbio registers. Arthritis & Rheumatology. 2014;66(Suppl. 11):S377-8. 27. Bliddal H, Eriksen SA, Christensen R, Lorenzen T, Hansen MS, Østergaard M et al. Adherence to methotrexate in rheumatoid arthritis treated by practice vs. hospital based rheumatologists: A Danish nationwide cohort study. Annals of the Rheumatic Diseases. 2014;73(Suppl. 2):448-9. 28. Keller A, Sørensen IJ, Østergaard M, Madsen OR, Asmussen KH, Møller JM et al. Does TNFα-inhibition influence the progression of degenerative changes in the lumbar spine in patients with axial spondylarthritis (ax-SpA)?. Annals of the Rheumatic Diseases. 2014;73(Suppl. 2):297. 29. Krabbe S, Bolce RJ, Brahe CH, Møller Døhn U, Wu G, Ejbjerg B et al. Validation of a multi-biomarker disease activity score in rheumatoid arthritis in relation to imaging inflammation and damage. Annals of the Rheumatic Diseases. 2014;73(Suppl. 2):396. 14. Juhl CB, Christensen R, Roos EM, Zhang W, Lund H. Impact of exercise type and dose on pain and disability in knee osteoarthritis: a systematic review and meta-regression analysis of randomized controlled trials. Arthritis & Rheumatism. 2014 mar;66(3):622-36. Tilgængelig fra: 10.1002/art.38290 30. Mercer L, Mariette X, Dixon W, Baecklund E, Hellgren K, Dreyer L et al. First results of a european registries collaborative project to compare the spectrum of lymphomas between different exposure groups in rheumatoid arthritis. Arthritis & Rheumatology. 2014;66(Suppl. 11):S806-7. 15. Jørgensen TSH, Hansen AH, Sahlberg M, Gislason GH, Torp-Pedersen C, Andersson C et al. Falls and comorbidity: The pathway to fractures. Scandinavian journal of public health. 2014 maj;42(3):287-94. Tilgængelig fra: 10.1177/1403494813516831 31. Mercer L, Askling J, Raaschou P, Dixon W, Dreyer L, Hetland ML et al. No increased risk of developing a first invasive melanoma in rheumatoid arthritis patients treated with biologics: Results of a collaborative project of 11 european biologics registers. Arthritis & Rheumatology. 2014;66(Suppl. 11):S807-8. 16. Krabbe S, Eshed I, Pedersen SJ, Bøyesen P, Møller JM, Therkildsen F et al. Bone marrow oedema assessment by magnetic resonance imaging in rheumatoid arthritis wrist and metacarpophalangeal joints: the importance of field strength, coil type and image resolution. Rheumatology (Oxford, England). 2014 aug;53(8):1446-51. Tilgængelig fra: 10.1093/rheumatology/keu029 32. Møller JM, Sørensen IJ, Thomsen HS, Østergaard M, Madsen OR, Pedersen SJ. Reproducibility of magnetic resonance diffusion weighted imaging in axial spondyloarthritis patients and healthy subjects. Annals of the Rheumatic Diseases. 2014;73(Suppl. 2):1122. 17. Lindhardsen J, Gislason GH, Jacobsen S, Ahlehoff O, Olsen A-MS, Madsen OR et al. Non-steroidal anti-inflammatory drugs and risk of cardiovascular disease in patients with rheumatoid arthritis: a nationwide cohort study. Annals of the Rheumatic Diseases. 2014;73:1515-1521 . Tilgængelig fra: 10.1136/annrheumdis-2012-203137 33. Møller JM, Sørensen IJ, Østergaard M, Thomsen H, Madsen OR, Pedersen SJ. Reproducibility of Magnetic resonance imaging diffusion weighted imaging in axial spondyloarthritis patients and healthy subjects. Arthritis & Rheumatology. 2014;66(Suppl. 11):S523. 18. Noiesen E, Trosborg I, Bager L, Herning M, Lyngby C, Konradsen H. Constipation - prevalence and incidence among medical patients acutely admitted to hospital with a medical condition. Journal of Clinical Nursing. 2014 aug 1;23(1516):2295-2302. Tilgængelig fra: 10.1111/jocn.12511 34. Poggenborg RP, Pedersen SJ, Eshed I, Sørensen IJ, Madsen OR, Møller JM et al. Whole-body and conventional magnetic resonance imaging for assessing inflammation and structural damage in psoriatic arthritis and axial spondyloarthritis. Scandinavian Journal of Rheumatology. 2014;43(Suppl. 127):74-5. 31 35. Ørnbjerg LM, Østergaard M, Bøyesen P, Jensen T, Thormann A, Tarp U et al. Impact of tumor necrosis factor inhibitor treatment on hand bone loss in rheumatoid arthritis patients treated in clinical practice: results from the nationwide Danish DANBIO registry. Scandinavian Journal of Rheumatology. 2014;43(Suppl. 127):27-8. 36. Østergaard M, Axelsen MB, Jacobsson LTH, Schaufelberger C, Hansen MS, Bijlsma JWJ et al. Dynamic magnetic resonance imaging in the assessment of the response to Certolizumab Pegol in rheumatoid arthritis patients: results from a phase IIIb randomized study. Arthritis & Rheumatology. 2014;66(Suppl. 11):S518-19. 32 Medicinsk afd. F Afdelingens specialer er medicinsk endokrinologi, gastroenterologi-hepatologi og intern medicin. Til afdelingen er knyttet Medicinsk forskningslaboratorium, som varetager såvel basal som klinisk forskning i afdelingens specialer samt Center for Diabetesforskning. I tillæg til den kliniske og laboratoriemæssige forskning har afdelingen et forskningsmiljø indenfor epidemiologi, klinisk farmakologi og farmakoepidemiologi knyttet til specialerne. Forskningen indgår i højt estimerede internationale og nationale forskningsnetværk. Forskningstemaer Jonatan Ising Bagger, læge Kristian Hallundbæk Mikkelsen, læge Mikkel Christensen, læge Morten Hansen, læge Nicolai Alexander Rhee, læge Signe Foghsgaard, læge Signe Harring Østoft, læge Tina Jorsal, læge Ulrich Rohde, læge Pelle Lau Ishøj (Psykiatrisk, Glostrup) Thomas Idorn (Nefrologisk, Rigshospitalet) Morten Buus Jørgensen (Rigshospitalet) Center for Diabetesforskning ledes af professor, Julie Rask (Psykiatrisk, Rigshospitalet) specialeansvarlig overlæge, dr. med. Tina Vilsbøll og Jacob Sivertsen, læge (Hjertemedicinsk) lektor, forskningsansvarlig overlæge, ph.d. Filip Krag Peter Godsk Jørgensen, læge (Hjertemedicinsk) Knop. Mette Gyldenløve (Hud- og allergiafd.) Hidtidige forskningsresultater har ændret forståelsen Thomas F. Dejgaard, læge (clinical supervisor) af diabetes og peger i retning af, at tarmen og tarmhormoner udgør vigtige mål for uopdagede sygdoms- Senior forskere mekanismer og dermed muligheder for nye behand- Jørgen Rungby, professor, overlæge, dr.med. lingsmetoder. Brynjulf Mortensen, ph.d., post.doc. Enheden repræsenterer et innovativt forskningsmiljø Heidi Storgaard, overlæge, ph.d. med et omfattende netværk af kliniske forskere, hvor Michael Røder, overlæge, dr. med. der udføres patientnær forskning af høj kvalitet - Thomas Peter Almdal, overlæge, dr. med. spændene fra basal fysiologi over human Louise Vedtofte, ph.d., post doc patofysiologi til randomiserede kliniske undersøgelser. Forskningsstipendiater Det overordnede mål er, at identificere og Emilie Bahne, stud.med. videreudvikle antidiabetiske behandlingsmodaliteter Emilie Skytte Andersen, stud.med. baseret på de beskrevne mekanismer og nye Magnus Grøndahl, stud.med behandlingsmetoder. Malthe Palm Suppli, stud.med. Pernille Mensberg, stud.scient. Center for Diabetesforskning blev som et af de få i Signe Nyby, stud.scient. Regionen tildelt Global Excellence prisen i 2014. Simon Vedfald, stud. med. Seniorforskere delestilling Thomas Almdal, overlæge, dr.med. Gastroenterologisk forskning Klinisk og epidemiologisk forskning i cøliaki Jørgen og malabsorption Rungby, adj. professor, overlæge, dr.med. Grundvidenskabelig og translatorisk forskning i strukturel cellebiologi og glatmu- Forskningsansvarlig overlæge skelfunktion Filip Krag Knop., overlæge, ph.d. Klinisk og epidemiologisk forskning i inflammatorisk tarmsygdom Forskningsansvarlig sygeplejerske Eline Noiesen, sygeplejerske, cand.mag. Ph.d. studerende Anders Ellekær Junker, læge Andreas Brønden, læge Asger Lund, læge David Peick Sonne, læge 33 Publikationer 2014 1. 2. 3. 4. 5. 6. 17. Chalmer T, Almdal TP, Vilsbøll T, Knop FK. Adverse drug reactions associated with the use of liraglutide in patients with type 2 diabetes - focus on pancreatitis and pancreas cancer. Expert Opinion on Drug Safety. 2014 nov 3;1-10. Tilgængelig fra: 10.1517/14740338.2015.975205 Abrahamsen B, Grove E, Vestergaard P. Nationwide registry-based analysis of cardiovascular risk factors and adverse outcomes in patients treated with strontium ranelate. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2014 feb;25(2):757-62. Tilgængelig fra: 10.1007/s00198-013-2469-4 18. Christensen M, Miossec P, Larsen BD, Werner U, Knop FK. The design and discovery of lixisenatide for the treatment of type 2 diabetes mellitus. Expert Opinion on Drug Discovery. 2014 aug 14;1-29. Tilgængelig fra: 10.1517/17460441.2014.942638 Almdal TP, Handlos LN, Valerius M, Juul E, Nielsen KE, Vistisen D et al. Glycaemic threshold for diabetes-specific retinopathy among individuals from Saudi Arabia, Algeria and Portugal. Diabetes research and clinical practice. 2014 mar;103(3):e44-6. Tilgængelig fra: 10.1016/j.diabres.2013.12.023 19. Comerma-Steffensen S, Grann M, Andersen C, Rungby J, Simonsen U. Cardiovascular effects of current and future anti-obesity drugs. Current Vascular Pharmacology. 2014 maj;12(3):493-504. Ampudia-Blasco FJ, Benhamou PY, Charpentier G, Consoli A, Diamant M, Gallwitz B et al. A Decision Support Tool for Appropriate Glucose-Lowering Therapy in Patients with Type 2 Diabetes. Diabetes Technology & Therapeutics. 2014 okt 27;17(3). Tilgængelig fra: 10.1089/dia.2014.0260 20. Ebdrup BH, Knop FK, Madsen A, Mortensen HB, Søgaard B, Holst JJ et al. Glucometabolic hormones and cardiovascular risk markers in antipsychotictreated patients. Journal of Clinical Psychiatry. 2014 sep;75(9):e899-905. Tilgængelig fra: 10.4088/JCP.13m08820 Bagger JI, Knop FK, Lund A, Holst JJ, Vilsbøll T. Glucagon responses to increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions in patients with type 2 diabetes and healthy individuals. Diabetologia. 2014 aug;57(8):1720-5. Tilgængelig fra: 10.1007/s00125-014-32642 21. Færch K, Carstensen B, Almdal TP, Jørgensen ME. Improved survival among patients with complicated type 2 diabetes in Denmark: a prospective study (20022010). The Journal of clinical endocrinology and metabolism. 2014 apr;99(4):E642-6. Tilgængelig fra: 10.1210/jc.2013-3210 Bak MJ, Wewer Albrechtsen NJ, Pedersen JH, Hartmann B, Christensen M, Vilsbøll T et al. Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in human. European journal of endocrinology / European Federation of Endocrine Societies. 2014 jan 10;170:529-538. Tilgængelig fra: 10.1530/EJE-13-0941 22. Gejl M, Rungby J, Brock B, Gjedde A. At the Centennial of Michaelis and Menten, Competing Michaelis-Menten Steps Explain Effect of GLP-1 on Blood-Brain Transfer and Metabolism of Glucose. Basic & clinical pharmacology & toxicology. 2014 aug;115(2):162-71. Tilgængelig fra: 10.1111/bcpt.12240 Bak MJ, Wewer Albrechtsen NJ, Pedersen J, Knop FK, Vilsbøll T, Jørgensen NB et al. Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): implications for GLP-1 measurements in clinical studies. Diabetes, Obesity and Metabolism Online. 2014 nov;16(11):1155-64. Tilgængelig fra: 10.1111/dom.12352 23. Gejl M, Lerche S, Mengel A, Møller N, Bibby BM, Smidt K et al. Influence of GLP-1 on myocardial glucose metabolism in healthy men during normo- or hypoglycemia. P L o S One. 2014;9(1):e83758. Tilgængelig fra: 10.1371/journal.pone.0083758 7. Bennett C, Klingenberg SL, Langholz E, Gluud LL. Tranexamic acid for upper gastrointestinal bleeding. Cochrane Database of Systematic Reviews. 2014 nov 21;11:CD006640. Tilgængelig fra: 10.1002/14651858.CD006640.pub3 24. Gluud LL, Knop FK, Vilsbøll T. Effects of lixisenatide on elevated liver transaminases: systematic review with individual patient data meta-analysis of randomised controlled trials on patients with type 2 diabetes. B M J Open. 2014;4(12):e005325. Tilgængelig fra: 10.1136/bmjopen-2014-005325 8. Brønden A, Hansen M, Sonne DP, Rohde U, Vilsbøll T, Knop FK. Sevelamer in a diabetologist's perspective: a phosphate-binding resin with glucoselowering potential. Diabetes, Obesity and Metabolism. 2014 jul 9;17(2):116120. Tilgængelig fra: 10.1111/dom.12355 9. 25. Hansen M, Sonne DP, Knop FK. Bile acid sequestrants: glucose-lowering mechanisms and efficacy in type 2 diabetes. Current Diabetes Reports. 2014 maj;14(5):482. Tilgængelig fra: 10.1007/s11892-014-0482-4 Burisch J, Pedersen N, Cukovic-Cavka S, Brinar M, Kaimakliotis I, Duricova D et al. East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort. Gut. 2014 apr;63(4):588-597. Tilgængelig fra: 10.1136/gutjnl-2013-304636 26. Hansen JC, Brock B, Bøtker HE, Gjedde A, Rungby J, Gejl M. Impact of glucagonlike peptide-1 on myocardial glucose metabolism revisited. Reviews in Endocrine & Metabolic Disorders. 2014 sep;15(3):219-31. Tilgængelig fra: 10.1007/s11154014-9286-8 10. Burisch J, Pedersen N, Cukovic-Cavka S, Turk N, Kaimakliotis I, Duricova D et al. Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe - An ECCO-EpiCom study. Journal of Crohn's & colitis. 2014;8(7):607. Tilgængelig fra: 10.1016/j.crohns.2013.11.021 11. Burisch J, Vegh Z, Pedersen N, Cuković-Čavka S, Turk N, Kaimakliotis I et al. Health care and patients' education in a European inflammatory bowel disease inception cohort: An ECCO-EpiCom study. Journal of Crohn's & colitis. 2014 aug 1;8(8):811-8. Tilgængelig fra: 10.1016/j.crohns.2013.12.023 12. Burisch J, Weimers P, Pedersen N, Cukovic-Cavka S, Vucelic B, Kaimakliotis I et al. Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with inflammatory bowel disease--an ECCO-EpiCom study. Journal of Crohn's & colitis. 2014 sep 1;8(9):1030-42. Tilgængelig fra: 10.1016/j.crohns.2014.01.028 13. Burisch J, Pedersen N, Cukovic-Cavka S, Turk N, Kaimakliotis I, Duricova D et al. Initial disease course and treatment in an inflammatory bowel disease inception cohort in Europe: the ECCO-EpiCom cohort. Inflammatory bowel diseases. 2014 jan;20(1):36-46. Tilgængelig fra: 10.1097/01.MIB.0000436277.13917.c4 14. Buse JB, Vilsbøll T, Thurman J, Blevins TC, Langbakke IH, Bøttcher SG et al. Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira). Diabetes Care. 2014 nov;37(11):2926-33. Tilgængelig fra: 10.2337/dc14-0785 15. Calanna S, Scicali R, Di Pino A, Knop FK, Piro S, Rabuazzo AM et al. Alphaand beta-cell abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes. Acta Diabetologica. 2014 aug;51(4):567-75. Tilgængelig fra: 10.1007/s00592-014-0555-5 16. Calanna S, Scicali R, Di Pino A, Knop FK, Piro S, Rabuazzo AM et al. Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2014 jun;24(6):670-6. Tilgængelig fra: 10.1016/j.numecd.2014.01.013 34 27. Hare KJ, Bonde L, Svare JA, Randeva HS, Asmar M, Hørup Larsen SM et al. Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabetic Medicine Online. 2014 aug;31(8):936-40. Tilgængelig fra: 10.1111/dme.12436 28. Hemmingsen B, Schroll JB, Wetterslev J, Gluud C, Vaag A, Sonne DP et al. Sulfonylurea versus metformin monotherapy in patients with type 2 diabetes: a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis. CMAJ open. 2014 jul;2(3):E162-75. Tilgængelig fra: 10.9778/cmajo.20130073 29. Idorn T, Knop FK, Jørgensen MB, Christensen M, Holst JJ, Hornum M et al. Elimination and Degradation of Glucagon-like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide in Patients with End-Stage Renal Disease. The Journal of clinical endocrinology and metabolism. 2014 jul;99(7):2457-66. Tilgængelig fra: 10.1210/jc.2013-3809 30. Idorn T, Knop FK, Jørgensen M, Holst JJ, Hornum M, Feldt-Rasmussen B. Postprandial responses of incretin and pancreatic hormones in non-diabetic patients with end-stage renal disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014;29(1):119-127. Tilgængelig fra: 10.1093/ndt/gft353 31. Ishøy PL, Knop FK, Broberg BV, Baandrup L, Fagerlund B, Jørgensen NR et al. Treatment of antipsychotic-associated obesity with a GLP-1 receptor agonist-protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-blinded intervention study: the TAO study protocol. B M J Open. 2014;4(1):e004158. Tilgængelig fra: 10.1136/bmjopen-2013-004158 32. Jensen TW, Hansen MS, Hørslev-Petersen K, Hyldstrup L, Abrahamsen B, Langdahl BL et al. Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial. Annals of the Rheumatic Diseases. 2014 maj 9;73(6):1123-1129. Tilgængelig fra: 10.1136/annrheumdis2012-203171 33. Junker AE, Als-Nielsen B, Gluud C, Gluud LL. Dopamine agents for hepatic encephalopathy. Cochrane Database of Systematic Reviews. 2014 feb 10;2:CD003047. Tilgængelig fra: 10.1002/14651858.CD003047.pub3 50. Pedersen DS, Locht LJ, Tran TP, Markholt S, Rungby J, Larsen A. Toxicological aspects of injectable gold-hyaluronan combination as a treatment for neuroinflammation. Histology and Histopathology. 2014 apr;29(4):447-56. 34. Jørgensen ME, Almdal TP, Faerch K. Reduced incidence of lower-extremity amputations in a Danish diabetes population from 2000 to 2011. Diabetic Medicine Online. 2014 apr;31(4):443-447. Tilgængelig fra: 10.1111/dme.12320 51. Pottegård A, Bjerregaard BK, Larsen MD, Larsen KS, Hallas J, Knop FK et al. Use of exenatide and liraglutide in Denmark: a drug utilization study. European journal of clinical pharmacology. 2014 feb;70(2):205-214. Tilgængelig fra: 10.1007/s00228013-1595-4 35. Knop FK, Lund A, Madsbad S, Holst JJ, Krarup T, Vilsbøll T. Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report. BMC research notes. 2014;7:326. Tilgængelig fra: 10.1186/1756-0500-7-326 36. Kähler P, Grevstad B, Almdal T, Gluud C, Wetterslev J, Vaag A et al. Targeting intensive versus conventional glycaemic control for type 1 diabetes mellitus: a systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. B M J Open. 2014;4(8):e004806. Tilgængelig fra: 10.1136/bmjopen-2014-004806 52. Prieto-Alhambra D, Lalmohamed A, Abrahamsen B, Arden NK, de Boer A, Vestergaard P et al. Oral bisphosphonate use and total knee/hip implant survival: validation of results in an external population-based cohort. Arthritis & Rheumatology. 2014 nov;66(11):3233-40. Tilgængelig fra: 10.1002/art.38789 53. Rhee NA, Ostoft SH, Holst JJ, Deacon CF, Vilsbøll T, Knop FK. The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects. European journal of endocrinology / European Federation of Endocrine Societies. 2014 sep;171(3):353-62. Tilgængelig fra: 10.1530/EJE-14-0314 37. Larsen JR, Vedtofte L, Holst JJ, Oturai P, Kjær A, Corell CU et al. Does a GLP1 receptor agonist change glucose tolerance in patients treated with antipsychotic medications?: Design of a randomised, double-blinded, placebocontrolled clinical trial. B M J Open. 2014;4(3):e004227. Tilgængelig fra: 10.1136/bmjopen-2013-004227 54. Rhee NA, Vilmann P, Hassan H, Hendel JW, Holst JJ, Vilsbøll T et al. The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract. Scandinavian journal of gastroenterology. 2014 jul 7;1-7. Tilgængelig fra: 10.3109/00365521.2014.934912 38. Liang B, Soka M, Christensen AH, Olesen MS, Larsen AP, Knop FK et al. Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis. Journal of Molecular and Cellular Cardiology. 2014;67:69-76. Tilgængelig fra: 10.1016/j.yjmcc.2013.12.014 55. Roed T, Kristoffersen US, Knudsen A, Wiinberg N, Lebech A-M, Almdal T et al. Increased prevalence of coronary artery disease risk markers in patients with chronic hepatitis C - a cross-sectional study. Vascular Health and Risk Management (Online). 2014;10:55-62. Tilgængelig fra: 10.2147/VHRM.S53557 39. Lund A, Bagger JI, Christensen M, Knop FK, Vilsbøll T. Glucagon and type 2 diabetes: the return of the alpha cell. Current Diabetes Reports. 2014 dec;14(12):555. Tilgængelig fra: 10.1007/s11892-014-0555-4 56. Rohde U, Gylvin S, Vilmann P, Friis SU, Langholz E, Vilsbøll T et al. Behandling med duodenal-jejunal bypass-sleeve ved svær overvægt. Ugeskrift for Laeger. 2014;176(20):1874-77. 40. Lund A, Knop FK, Vilsbøll T. Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities. European journal of internal medicine. 2014 jun;25(5):407-14. Tilgængelig fra: 10.1016/j.ejim.2014.03.005 57. Rohde U, Gylvin S, Vilmann P, Friis SU, Langholz E, Vilsbøll T et al. Duodenaljejunal bypass sleeve - a potential alternative to bariatric surgery?. Ugeskrift for læger [online]. 2014 sep 8;176(37). 41. Lundby-Christensen L, Tarnow L, Hansen DL, Worm D, Naver LS, Hvolris LE et al. Carotid intima-media thickness is reduced 12months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance. Journal of Diabetes and its Complications. 2014 apr 2;28(4):517-22. Tilgængelig fra: 10.1016/j.jdiacomp.2014.03.005 42. Mor A, Svensson E, Rungby J, Ulrichsen SP, Berencsi K, Nielsen JS et al. Modifiable clinical and lifestyle factors are associated with elevated alanine aminotransferase levels in newly diagnosed type 2 diabetes patients: results from the nationwide DD2 study. Diabetes - Metabolism: Research and Reviews (Online). 2014 nov;30(8):707-15. Tilgængelig fra: 10.1002/dmrr.2539 43. Nielsen JS, Rungby J, Christiansen JS, Vaag A, Friborg S, Sørensen HT et al. DD2 - nye veje i behandlingen af type 2-diabetes. Ugeskrift for læger [online]. 2014 jun 2;176(11A). 58. Shane E, Burr D, Abrahamsen B, Adler RA, Brown TD, Cheung AM et al. Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American Society for Bone and Mineral Research. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014 jan;29(1):1-23. Tilgængelig fra: 10.1002/jbmr.1998 59. Sonne DP, Hansen M, Knop FK. MECHANISMS IN ENDOCRINOLOGY: Bile acid sequestrants in type 2 diabetes: potential effects on GLP1 secretion. European journal of endocrinology / European Federation of Endocrine Societies. 2014 aug;171(2):R47-R65. Tilgængelig fra: 10.1530/EJE-14-0154 60. Sonne DP, Lund A, Faber J, Holst JJ, Vilsbøll T, Knop FK. On the role of gallbladder emptying and incretin hormones for nutrient-mediated TSH suppression in patients with type 2 diabetes. Endocrine Connections. 2014 dec;3(4):193-9. Tilgængelig fra: 10.1530/EC-14-0088 44. Nissen AGB, Christensen M, Knop FK, Vilsbøll T, Holst JJ, Hartmann B. Glucose-dependent Insulinotropic Polypeptide Inhibits Bone Resorption in Humans. The Journal of clinical endocrinology and metabolism. 2014 aug 21;jc20142547. Tilgængelig fra: 10.1210/jc.2014-2547 61. Sonne DP, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK. Postprandial gallbladder emptying in patients with type 2 diabetes: potential implications for bile-induced secretion of glucagon-like peptide 1. European journal of endocrinology / European Federation of Endocrine Societies. 2014 okt;171(4):407-19. Tilgængelig fra: 10.1530/EJE-14-0309 45. Noiesen E, Trosborg I, Bager L, Herning M, Lyngby C, Konradsen H. Constipation - prevalence and incidence among medical patients acutely admitted to hospital with a medical condition. Journal of Clinical Nursing. 2014 aug 1;23(1516):2295-2302. Tilgængelig fra: 10.1111/jocn.12511 62. Storgaard H, Mortensen B, Almdal T, Laub M, Tarnow L. At least one in three people with Type 2 diabetes mellitus referred to a diabetes centre has symptomatic obstructive sleep apnoea. Diabetic Medicine. 2014 nov;31(11):1460-7. Tilgængelig fra: 10.1111/dme.12477 46. Nygaard SB, Larsen A, Knuhtsen A, Rungby J, Smidt K. Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells. BMC research notes. 2014;7:84. Tilgængelig fra: 10.1186/1756-0500-7-84 63. Storgaard H, Gluud LL, Christensen M, Knop FK, Vilsbøll T. The effects of sodium-glucose co-transporter 2 inhibitors in patients with type 2 diabetes: protocol for a systematic review with meta-analysis of randomised trials. B M J Open. 2014;4(8):e005378. 47. Ostoft SH, Bagger JI, Hansen T, Pedersen O, Faber J, Holst JJ et al. GlucoseLowering Effects and Low Risk of Hypoglycemia in Patients With Maturity-Onset Diabetes of the Young When Treated With a GLP-1 Receptor Agonist: A Double-Blind, Randomized, Crossover Trial. Diabetes Care. 2014 jul;37(7):1797805. Tilgængelig fra: 10.2337/dc13-3007 64. Støy J, Grarup N, Hørlyck A, Ibsen L, Rungby J, Poulsen PL et al. Blood pressure levels in male carriers of Arg82Cys in CD300LG. P L o S One. 2014;9(10):e109646. Tilgængelig fra: 10.1371/journal.pone.0109646 65. Suresh E, Pazianas M, Abrahamsen B. Safety issues with bisphosphonate therapy for osteoporosis. Rheumatology (Oxford, England). 2014 jan;53(1):19-31. Tilgængelig fra: 10.1093/rheumatology/ket236 48. Ostoft SH, Bagger JI, Hansen T, Pedersen O, Holst JJ, Knop FK et al. Incretin effect and glucagon responses to oral and intravenous glucose in patients with maturity-onset diabetes of the young-type 2 and type 3. Diabetes. 2014 aug;63(8):2838-44. Tilgængelig fra: 10.2337/db13-1878 49. Pedersen N, Thielsen P, Martinsen L, Bennedsen M, Haaber A, Langholz E et al. eHealth: Individualization of Mesalazine Treatment Through a Self-managed Web-based Solution in Mild-to-moderate Ulcerative Colitis. Inflammatory bowel diseases. 2014 dec;20(12):2276-85. Tilgængelig fra: 10.1097/MIB.0000000000000199 35 66. Svensson E, Mor A, Rungby J, Berencsi K, Nielsen JS, Stidsen J et al. Lifestyle and clinical factors associated with elevated C-reactive protein among newly diagnosed Type 2 diabetes mellitus patients: a cross-sectional study from the nationwide DD2 cohort. B M C Endocrine Disorders. 2014;14:74. Tilgængelig fra: 10.1186/1472-6823-14-74 67. Telinius N, Baandrup U, Rumessen J, Pilegaard H, Hjortdal VE, Aalkjaer C et al. The human thoracic duct is functionally innervated by adrenergic nerves. A J P: Heart and Circulatory Physiology (Online). 2014 jan;306(2):H206-13. Tilgængelig fra: 10.1152/ajpheart.00517.2013 68. van Poppel PCM, van Asseldonk EJP, Holst JJ, Vilsbøll T, Netea MG, Tack CJ. The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance. Diabetes, Obesity and Metabolism Online. 2014 dec;16(12):1269-73. Tilgængelig fra: 10.1111/dom.12357 69. Vrieze A, Out C, Fuentes S, Jonker L, Reuling I, Kootte RS et al. Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome. Journal of Hepatology. 2014 apr;60(4):824-831. Tilgængelig fra: 10.1016/j.jhep.2013.11.034 70. Wewer Albrechtsen NJ, Hartmann B, Veedfald S, Windeløv JA, Plamboeck A, Bojsen-Møller KN et al. Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?. Diabetologia. 2014 sep;57(9):1919-26. Tilgængelig fra: 10.1007/s00125-014-3283-z 71. Wilkens Knudsen A, Jensen J-EB, Nordgaard-Lassen I, Almdal T, Kondrup J, Becker U. Nutritional intake and status in persons with alcohol dependency: data from an outpatient treatment programme. European Journal of Nutrition. 2014 okt;53(7):1483-92. Tilgængelig fra: 10.1007/s00394-014-0651-x Kommentar/debat 72. Grove E, Abrahamsen B, Vestergaard P. Response: Is heart failure a debatable end-point for bisphosphonate treatment in an older osteoporotic population? (letter). Journal of internal medicine. 2014 feb;275(2):198. Tilgængelig fra: 10.1111/joim.12151 73. Idorn T, Knop FK, Jørgensen M, Holst JJ, Hornum M, Feldt-Rasmussen B. The authors reply:. Kidney International. 2014 jan;85(1):212-3. Tilgængelig fra: 10.1038/ki.2013.410 74. Wildt S, Lassen IN, Rumessen JJ. Incorrect citation and analysis in metaanalysis. Inflammatory Bowel Diseases. 2014;20(12):E25. Tilgængelig fra: 10.1097/MIB.0000000000000249 Konferenceabstrakt i tidsskrift 75. Ebdrup BH, Knop FK, Madsen A, Mortensen HB, Søgaard B, Holst JJ et al. Glucometabolic Hormones and Cardiovascular Risk Markers in AntipsychoticTreated Patients. Schizophrenia Research. 2014 apr;153(Suppl. 1):90. Ph.d.-afhandling 76. Christensen M. Glucose-dependent insulinotropic polypeptide (GIP): Effects on insulin and glucagon secretion in humans. 2014. 77. Sonne DP. On the role of gallbladder emptying and bile acids for postprandial GLP-1 secretion. 2014. 78. Østoft SH. Incretin hormones and maturity onset diabetes of the young – pathophysiological implications and antidiabetic treatment potential. 2014. 36 Ortopædkirurgisk afd. Forskningstemaer 2. Berthelsen CB, Lindhardt Damsgaard T, Frederiksen K. Maintaining Unity - relatives in older patients' fast-track treatment programmes. A grounded theory study. Journal of Advanced Nursing. 2014 apr 1;70(12):2746-56. Tilgængelig fra: 10.1111/jan.12407 3. Boeckstyns MEH, Herzberg G. Periprosthetic osteolysis after total wrist arthroplasty. Journal of Wrist Surgery. 2014 maj;3(2):101-6. Tilgængelig fra: 10.1055/s-00341372532 4. Boeckstyns MEH, Merser S. Psychometric properties of two questionnaires in the context of total wrist arthroplasty. Danish Medical Bulletin (Online). 2014 nov;61(11):A4939. 5. Boeckstyns MEH, Toxværd A, Bansal M, Vadstrup LS. Wear particles and osteolysis in patients with total wrist arthroplasty. Journal of Hand Surgery (American Volume). 2014 dec;39(12):2396-404. Tilgængelig fra: 10.1016/j.jhsa.2014.07.046 6. Boeckstyns MEH. Wrist arthroplasty--a systematic review. Danish Medical Bulletin (Online). 2014 maj;61(5):A4834. 7. Bøttcher Berthelsen C, Lindhardt Damsgaard T, Frederiksen K. Inhibiting Interference - a grounded theory of health professionals' pattern of behaviour related to the relatives of older patients in fast-track treatment programmes. Scandinavian journal of caring sciences. 2014 sep;28(3):609-17. Tilgængelig fra: 10.1111/scs.12126 8. Christensen JF, Jones LW, Tolver A, Jørgensen LW, Andersen JL, Adamsen L et al. Safety and efficacy of resistance training in germ cell cancer patients undergoing chemotherapy: a randomized controlled trial. B J C. 2014 jul 1;111(1):8-16. Tilgængelig fra: 10.1038/bjc.2014.273 9. Dahl JB, Nielsen RV, Wetterslev J, Nikolajsen L, Hamunen K, Kontinen VK et al. Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. Acta anaesthesiologica Scandinavica. 2014 aug 14;58(10):1165-1181. Tilgængelig fra: 10.1111/aas.12382 Pårørendes rolle under den ældre patients accelererede operationsforløb ved total hofte- eller knæalloplastik – praksisforankret teoriudvikling Udvikling og afprøvning af et empowermentorienteret undervisningsprogram rettet mod rehabiliteringsperioden efter et accelereret hoftealloplastikforløb Fremmedelegemeinfektion - et dyreeksperimentelt studium omfattende undersøgelse af vaccination som forebyggende behandling af proteseinfektion PROM RSA Problemstillinger i forhold til fast-track forløb Problemstillinger i forhold til proteserelateret infektion Videnskabelige medarbejdere Ph.d. studerende Mikkel Rathsach Andersen, læge Kirsten Szöts, sygeplejerske, cand.cur. 10. Dan-Nielsen S, Wewer V, Paerregaard A, Hansen LF, Nielsen RG, Lange A et al. Does infliximab prevent colectomy in acute and chronic active ulcerative colitis?. Journal of Pediatric Gastroenterology and Nutrition. 2014 jun;58(6):768-72. Tilgængelig fra: 10.1097/MPG.0000000000000340 Andet forskningsaktivt personale Anders Odgaard, overlæge Henrik Morville Schrøder, overlæge 11. Eriksen P, Bartels EM, Altman RD, Bliddal H, Juhl CB, Christensen R. Risk of bias and brand explain the observed inconsistency in trials on glucosamine for symptomatic relief of osteoarthritis: a meta-analysis of placebo-controlled trials. Arthritis Care & Research. 2014 dec;66(12):1844-55. Tilgængelig fra: 10.1002/acr.22376 12. Grevstad U, Mathiesen O, Lind T, Dahl JB. Effect of adductor canal block on pain in patients with severe pain after total knee arthroplasty: a randomized study with individual patient analysis. British Journal of Anaesthesia. 2014 jan 8;112(5):91219. Tilgængelig fra: 10.1093/bja/aet441 13. Gudmann KNS, Wang J, Hoielt S, Chen P, Siebuhr AS, He Y et al. Cartilage turnover reflected by metabolic processing of type II collagen: a novel marker of anabolic function in chondrocytes. International Journal of Molecular Sciences (Online). 2014;15(10):18789-803. Tilgængelig fra: 10.3390/ijms151018789 14. Gvozdenovic R, Boeckstyns M. Collateral ligament reconstruction of the chronic thumb injury with bio-tenodesis screw fixation. Techniques in Hand & Upper Extremity Surgery. 2014 dec;18(4):160-4. Tilgængelig fra: 10.1097/BTH.0000000000000058 15. Hansen JB, Juhl CB, Boutron I, Tugwell P, Ghogomu EAT, Pardo Pardo J et al. Assessing bias in osteoarthritis trials included in Cochrane reviews: protocol for a meta-epidemiological study. B M J Open. 2014;4(10):e005491. Tilgængelig fra: 10.1136/bmjopen-2014-005491 16. Henriksen M, Creaby MW, Lund H, Christensen R, Juhl CB. Is there a causal link between knee loading and knee osteoarthritis progression?: A systematic review and meta-analysis of cohort studies and randomised trials. B M J Open. 2014;4(7):e005368. Tilgængelig fra: 10.1136/bmjopen-2014-005368 17. Husted H, Schrøder H, Odgaard A, Troelsen A. Knæartrose - diagnostik og behandling. Ugeskrift for læger [online]. 2014 jun 9;176(12):V03130155 . Thomas Lind, overlæge Søren Solgaard, overlæge Niels Søe, overlæge Michel Boeckstyns, overlæge Claus Hjort Jensen, overlæge Lars Vadstrup, overlæge Rasmus Nielsen, 1.reservelæge Carsten Bogh Juhl, Forsknings- og udviklingsfysioterapeut Susanne Boel, Forsknings- og udviklingsergoterapeut Forskningsansvarlig overlæge Anders Odgaard Udviklings-/Forskningsansvarlig sygeplejerske Louise Bager, klinisk sygeplejespecialist Publikationer 2014 1. Andersen M, Boesen M, Ellegaard K, Christensen R, Söderström K, Søe N et al. Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross-sectional study. Arthritis Research & Therapy. 2014;16(3):R107. Tilgængelig fra: 10.1186/ar4557 37 18. Husted H, Schrøder H, Odgaard A, Troelsen A. Knæartrose set fra ortopædkirurgens synsvinkel. Ugeskrift for læger [online]. 2014 jun 9;176(12):1139-1142. 12/2014. 19. Høgdal N, Juhl CB, Aadahl M, Gluud C. Early preventive exercises versus usual care does not seem to reduce trismus in patients treated with radiotherapy for cancer in the oral cavity or oropharynx: A randomised clinical trial. Acta oncologica (Stockholm, Sweden). 2014 sep 17;54:80-87. Tilgængelig fra: 10.3109/0284186X.2014.954677 20. Juhl CB, Christensen R, Roos EM, Zhang W, Lund H. Impact of exercise type and dose on pain and disability in knee osteoarthritis: a systematic review and meta-regression analysis of randomized controlled trials. Arthritis & Rheumatism. 2014 mar;66(3):622-36. Tilgængelig fra: 10.1002/art.38290 21. Jæger P, Koscielniak-Nielsen ZJ, Schrøder HM, Mathiesen O, Henningsen MH, Lund J et al. Adductor canal block for postoperative pain treatment after revision knee arthroplasty: a blinded, randomized, placebo-controlled study. P L o S One. 2014;9(11):e111951. Tilgængelig fra: 10.1371/journal.pone.0111951 22. Jørgensen CC, Kjaersgaard-Andersen P, Solgaard S, Kehlet H. Hip dislocations after 2,734 elective unilateral fast-track total hip arthroplasties: incidence, circumstances and predisposing factors. Archives of orthopaedic and trauma surgery. 2014;134 (11):1615-1622. Tilgængelig fra: 10.1007/s00402-014-2051-3 23. Krenk L, Kehlet H, Bæk Hansen T, Solgaard S, Soballe K, Rasmussen LS. Cognitive dysfunction after fast-track hip and knee replacement. Anesthesia and Analgesia. 2014;118(5):1034-40. Tilgængelig fra: 10.1213/ANE.0000000000000194 24. Lindberg-Larsen M, Jørgensen CC, Bæk Hansen T, Solgaard S, Odgaard A, Kehlet H. Re-admissions, re-operations and length of stay in hospital after aseptic revision knee replacement in Denmark: a two-year nationwide study. The bone & joint journal. 2014;96-B(12):1649-56. Tilgængelig fra: 10.1302/0301-620X.96B12.33621 25. Mackey AL, Karlsen A, Couppé C, Mikkelsen UR, Nielsen RH, Magnusson SP et al. Differential satellite cell density of type I and II fibres with lifelong endurance running in old men. Acta physiologica (Oxford, England). 2014 mar;210(3):612-27. Tilgængelig fra: 10.1111/apha.12195 26. Nielsen RH, Clausen NM, Schjerling P, Larsen JO, Martinussen T, List EO et al. Chronic alterations in growth hormone/insulin-like growth factor-I signaling lead to changes in mouse tendon structure. Matrix biology : journal of the International Society for Matrix Biology. 2014 feb;34:96-104. Tilgængelig fra: 10.1016/j.matbio.2013.09.005 27. Noiesen E, Trosborg I, Bager L, Herning M, Lyngby C, Konradsen H. Constipation - prevalence and incidence among medical patients acutely admitted to hospital with a medical condition. Journal of Clinical Nursing. 2014 aug 1;23(1516):2295-2302. Tilgængelig fra: 10.1111/jocn.12511 28. Pedersen EG, Pottegård A, Hallas J, Friis S, Hansen K, Jensen PEH et al. Myasthenia and risk of cancer: a population-based case-control study. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2014 maj;21(5):773-8. Tilgængelig fra: 10.1111/ene.12383 29. Skou ST, Simonsen ME, Odgaard A, Roos EM. Predictors of long-term effect from education and exercise in patients with knee and hip pain. Danish Medical Bulletin (Online). 2014 jul;61(7):A4867. 30. Solgaard S, Kjersgaard AG. Increased risk for early periprosthetic fractures after uncemented total hip replacement. Danish Medical Bulletin (Online). 2014 feb;61(2):A4767. 31. Sun S, Bay-Jensen A-C, Karsdal MA, Siebuhr AS, Zheng Q, Maksymowych WP et al. The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases. B M C Musculoskeletal Disorders. 2014;15:93. Tilgængelig fra: 10.1186/1471-2474-15-93 32. Szöts K, Konradsen H, Solgaard S, Ostergaard B. Telephone follow-up by nurse following total knee arthroplasty - protocol for a randomized clinical trial (NCT 01771315). B M C Nursing. 2014;13:14. Tilgængelig fra: 10.1186/14726955-13-14 33. Vadstrup LS, Jørring S, Bernt P, Boeckstyns MEH. Base fractures of the fifth proximal phalanx can be treated conservatively with buddy taping and immediate mobilisation. Danish Medical Bulletin (Online). 2014 aug;61(8):A4882. 38 Røntgen- og skannings afd. Forskningstemaer Screening for lungecancer med CT Optimal billeddiagnostik ved primær hyperparathy- Publikationer 2014 reoidisme (Skintigrafi, SPECT, PET og 4DCT). Effekt på arteriel inflammation ved biologisk be- 1. Bækgaard N, Just S, Foegh P. Which criteria demand additive stenting during catheter-directed thrombolysis?. Phlebology / Venous Forum of the Royal Society of Medicine. 2014 maj 19;29(1 suppl):112-118. Tilgængelig fra: 10.1177/0268355514528842 2. Egsmose EL, Birkvig M, Buhl T, Madsen OR. FRAX fracture risk in women with a recent fracture of the distal forearm: agreement between assessments with and without bone mineral density and impact of measurement side in the individual patient. Clinical rheumatology. 2014 maj 14. Tilgængelig fra: 10.1007/s10067-0142640-0 3. Greve SV, Blicher TM, Blyme A, Sehestedt T, Hansen TW, Rasmussen SL et al. Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals. Journal of hypertension. 2014 maj;32(5):1034-41; discussion 1041. Tilgængelig fra: 10.1097/HJH.0000000000000147 4. Jensen P, Zachariae C, Christensen R, Geiker NRW, Schaadt BK, Stender S et al. Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis. Acta Dermatovenereologica. 2014 feb 20;94(6):691-4. Tilgængelig fra: 10.2340/00015555-1824 5. Konge L, Albrecht-Beste E, Nielsen MB. Virtual-reality simulation-based training in ultrasound. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2014 apr;35(2):95-7. Tilgængelig fra: 10.1055/s-0034-1366191 6. Pallisgaard J, Stride NO, Myschetzky PS, Bech J. Fisteldannende kæmpekoronararterieaneurisme hos 62-årig kvinde indlagt med brystsmerter. Ugeskrift for læger [online]. 2014 dec 15. 7. Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF et al. Screening for lungecancer med lavdosis-CT - danske og udenlandske resultater. Ugeskrift for læger [online]. 2014 okt 13;176(42):V05140283. 8. Strandberg C, Wilkens R. Transabdominal ultralydskanning af tarmen er et godt supplement ved diagnostik af tarmsygdomme. Ugeskrift for læger. 2014 mar 3;176(5):451-454. V12120694. 9. Thamsborg AKM, Krakauer M, Fahrenkrug L. Tilfældigt fund af urinblære i scrotum ved scintigrafi. Ugeskrift for læger [online]. 2014 jul 21;176(30). handling af reumatoid artrit (CT, FDG-PET/CT og Ultralyd) Bedre estimering af forventet postoperativ lungefunktion på lungelap-niveau (Lungeskintigrafi med SPECT/CT) hos patienter med lungecancer. Undersøge effekt af liraglutide (glucagon-like peptide-1 (GLP-1)) receptoragonist på glukosetolerance og risiko for at udvikle type 2 diabetes hos kvinder med tidligere gestationel diabetes. Undersøges med bl. a. helkrops DXA-skanning. Effekt af duodenal-jejunal bypass sleeve, undersøgt blandt andet med DXA skanning (DJBS). Afdække årsager til astma og allergi. Undersøgelse af børn (COPSAC 2010) med bl. a. helkrops DXAskanning. Endokrine forandringer efter gastrisk bypass kirurgi, undersøgt blandt andet med helkrops DXA-skanning (RYGB). Sammenhængen mellem fedtlever og glukagon resistens. Undersøgelse af normalvægtige og overvægtige med blandt andet helkrops DXA-skanning (SIRG-1)." Verdict-projekt - Hvor vidt kan hjerte-CT erstatte KAG i den akutte fase ? Forskningsansvarlige overlæger Peter Sand Myschetzsky, overlæge Radiologisk Martin Krakauer, overlæge Nuklearmedicinsk 39