Raport 2008 - Uniwersytet Jagielloński

Transcription

FACULTY OF BIOCHEMISTRY, BIOPHYSICS
AND BIOTECHNOLOGY
JAGIELLONIAN UNIVERSITY
ANNUAL REPORT
2008
FACULTY OF BIOCHEMISTRY, BIOPHYSICS
AND BIOTECHNOLOGY
JAGIELLONIAN UNIVERSITY
ANNUAL REPORT 2008
Gronostajowa 7
30-387 Kraków, Poland
tel.: (48) 012 6646002
fax.: (48) 012 6646902
e-mail: [email protected]
internet: http://wbbib.uj.edu.pl
Edited by S. Więckowski
Editorial board: M. Elas, M. Tworzydło
Photographs: A. Matysik
Type set: J. Golda
Printed by: Quartis
CONTENTS
About the Faculty of Biochemistry, Biophysics and Biotechnology,
Jagiellonian University
1. Authorities, Faculty Council
2. Administration
3. Research Departments and Laboratories:
3.1.1. Department of Biophysics, Laboratory of Photobiophysics
3.1.2. Department of Biophysics, Laboratory of Radiospectroscopy of
Cancer and Radiobiology
3.1.3. Department of Biophysics, Laboratory of Spectroscopic Methods
of Studying Biomolecules’ Structure and Function
3.2. Department of Computational Biophysics and Bioinformatics
3.3. Department of Analytical Biochemistry
3.4. Department of Cellular Biochemistry
3.5. Department of Physical Biochemistry
3.6. Department of General Biochemistry
3.7. Department of Cell Biology
3.8. Department of Immunology
3.9. Department of Microbiology
3.10. Department of Medical Biotechnology
3.11. Department of Plant Physiology and Biochemistry
3.12. Department of Plant Physiology and Development
3.13. Department of Molecular Genetics
3.14. Laboratory of Molecular Genetics and Virology
3.15. Laboratory of Cell Biophysics
4.1. DSc degrees
4.2. PhD degrees
5. Publications 2008
6. Patents
7. Conferences organized by the FBB&B
8. Active Participations in National and International Meetings
9. Visitors/Guest lecturers
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ABOUT FACULTY OF BIOCHEMISTRY, BIOPHYSICS
AND BIOTECHNOLOGY, JAGIELLONIAN UNIVERSITY
Faculty of Biochemistry, Biophysics, and Biotechnology comprises 13 departments and 2 laboratories. A total of 104 academic
members of staff, including 19 professors, together with 40 laboratory specialists and 12 administration personnel are employed.
The teaching activities of the Faculty are concentrated within
the two degree disciplines of biotechnology and biophysics. For
the academic year 2010/2011 a new degree programme in biochemistry is to be launched. In addition, the Faculty runs post-diploma studies in molecular biology as well as a four-year PhD
programme in biochemistry and biophysics. Every year the Faculty awards approximately 70 MSc degrees and almost 20 individuals obtain a PhD degree.
Research concentrates not only on problems of biochemistry, biophysics and biotechnology, but also involves work into microbiology, immunology, virology, cell biology, plant physiology.
Faculty of Biochemistry, Biophysics and Biotechnology cooperates fruitfully with over eighty Polish and foreign academic
centres. Moreover, in recent years the Faculty started to collaborate with pharmaceutical and biotechnology industry as well as
with hospitals.
v
1. AUTHORITIES, FACULTY COUNCIL
till August 31, 2008
Dean Professor Kazimierz Strzałka
Vice-Dean for General Affairs Professor Adam Dubin
Vice-Dean for International Professor Józef Dulak
Scientific Cooperation
Vice-Dean for Student Affairs Assoc. Professor Amalia Guzdek
from September 1, 2008
Dean Professor Wojciech Froncisz
Vice-Dean for General Affairs Professor Andrzej Kozik
Vice-Dean for International Assoc. Professor Jerzy Dobrucki
Scientific Cooperation
Vice-Dean for Student Affairs Professor Marta Dziedzicka-Wasylewska
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Faculty Council Joanna Bereta (PhD, DSc), Jan Białczyk
(PhD, DSc), Joanna Cichy (PhD, DSc), Jerzy
Dobrucki (PhD, DSc), Adam Dubin (PhD,
DSc, Prof.), Józef Dulak (PhD, DSc, Prof.),
Leszek Fiedor (PhD, DSc), Wojciech Froncisz (PhD, DSc, Prof.), Halina Gabryś (PhD,
DSc, Prof.), Ryszard Gurbiel (PhD, DSc),
Amalia Guzdek (PhD, DSc), Alicja Józkowicz
(PhD, DSc), Jolanta Jura (PhD, DSc), Maria
Kapiszewska (PhD, DSc, Prof.), Andrzej Klein (PhD, DSc, Prof.), Anna Kordowiak (PhD,
DSc, Prof.), Witold Korytowski (PhD, DSc),
Bernard Korzeniewski (PhD, DSc), Andrzej
Kozik (PhD, DSc, Prof.), Jerzy Kruk (PhD,
DSc), Zbigniew Madeja (PhD, DSc), Jacek
Międzobrodzki (PhD, DSc), Artur Osyczka
(PhD, DSc), Marta Pasenkiewicz-Gierula
(PhD, DSc, Prof.), Jan Potempa (PhD, DSc,
Prof.), Juliusz Pryjma (MD, DSc, Prof.), Hanna Rokita (PhD, DSc, Prof.), Tadeusz Sarna
(PhD, DSc, Prof.), Kazimierz Strzałka (PhD,
DSc, Prof.), Krystyna Urbańska (PhD, DSc)
from April 8, 2008
Jarosław Czyż (PhD, DSc)
from March 1, 2008
Marta Dziedzicka-Wasylewska (PhD, DSc, Prof.)
till September 30, 2008
Alicja Ziemienowicz (PhD, DSc)
Scientific Secretary Assoc. Professor Krystyna Urbańska
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Representatives of Younger Marta Michalik (PhD), Beata Płonka (PhD)
Academic Teachers
till April 7, 2008
Jarosław Czyż (PhD)
Krzysztof Murzyn (PhD), Bohdan Turyna
(PhD)
from October 1, 2008
Krzysztof Guzik (PhD), Sylwia KędrackaKrok (PhD), Joanna Kozieł (PhD), Jolanta
Sroka (PhD), Kinga Wójcik (PhD)
Representatives of Technicians Izabela Turyna (MSc)
Lidia Ciastoń (MSc), Barbara Czuba-Pełech
(Eng), Elżbieta Sater
Representatives of Students Przemysław Cichoń, Ewa Chrostek, Anna
Malara, Paweł Szczęśniak, Kamila Szulc
Agnieszka Grabowiecka, Agnieszka Kabat,
Katarzyna Kmiecik, Kamil Kruczek, Kornelia
Mikuła, Sebastian Pintscher
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Representatives of PhD Students Filip Gołębiowski (MSc), Ewelina Król (MSc),
Janusz Ligęza (MSc), Olga Sztatelman (MSc)
Representatives of Trade Union Ewa Heliasz-Kwak (Eng)
Lidia Ciastoń (MSc)
Jadwiga Golda (MSc)
2. ADMINISTRATION
Faculty Secretariat Jadwiga Gołda, Paulina Szaflik
till July 17, 2008
Małgorzata Wierucka
Students Affairs Office Małgorzata Calikowska, Janina Mrugalska (MSc)
Dorota Żołnierczyk
Administrative Officer Waldemar Śnieżyński (MSc, Eng)
till July 31, 2008
Financial Affairs Jadwiga Fabrowska-Flisak
till November 17, 2008
Aleksandra Pilarska
from April 1, 2008
Marek Jung (MSc)
from June 5, 2008
Kinga Mierniczek (MSc, Eng)
Laboratory Equipment
Ewa Heliasz-Kwak (Eng)
Informatics Service Wojciech Pilch
Workshop Franciszek Dziedzic, Piotr Urbański
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3. RESEARCH DEPARTMENTS AND LABORATORIES
Department of Biophysics
• Laboratory of Photobiophysics
• Laboratory of Radiospectroscopy of Cancer and Radiobiology
• Laboratory of Spectroscopic Methods of Studying Biomolecules’ Structure
and Function
Department of Computational Biophysics and Bioinformatics
Department of Analytical Biochemistry
Department of Cellular Biochemistry
Department of Physical Biochemistry
Department of General Biochemistry
Department of Cell Biology
Department of Immunology
Department of Microbiology
Department of Medical Biotechnology
Department of Plant Physiology and Biochemistry
Department of Plant Physiology and Development
Department of Molecular Genetics
Laboratory of Molecular Genetics and Virology
Laboratory of Cell Biophysics
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3.1.1. DEPARTMENT OF BIOPHYSICS
LABORATORY OF PHOTOBIOPHYSICS
Head of the Department
Tadeusz Sarna (PhD, DSc, Professor)
Head of the Laboratory
Academic staff
Witold Korytowski (PhD, DSc), Magda NiziołekKierecka (PhD), Tomasz Panz (PhD), Anna
Pawlak (PhD), Anna Wiśniewska (PhD, DSc),
Agnieszka Wolnicka-Głubisz (PhD), Mariusz
Zaręba (PhD)
Supporting staff
Agnieszka Broniec (PhD), Barbara Czuba-Pełech (Eng), Jacek Wronka (MSc, Eng), Grażyna Żmuda
PhD students
Patrycja Kaczara (MSc), Magdalena Olchawa
(MSc), Anna Piłat (MSc), Grzegorz Szewczyk
(MSc), Andrzej Żądło (MSc)
MSc students
graduated in 2008
Biology: Edyta Borkowska
Biological Chemistry: Magdalena Lepiarczyk,
Agnieszka Zuber
Medical Physics: Anna Głogowska
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Research focus
• The molecular and cellular mechanisms of phototoxicity to the eye and
skin
• The photoprotective and antioxidant properties of melanin pigments and carotenoids
• The biophysics of oxidative stress, role of the peroxidation of lipids in
cytotoxicity and the strategies of its prevention
• The role of singlet oxygen and free radicals in photoxidation reaction
mediated by new generation photosensitizers
Publications
Jańczyk A, Wolnicka-Głubisz A, Urbańska K, Kisch H, Stochel G, Macyk W.
Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light. Free Radic Biol Med 2008; 44: 1120-30.
Jańczyk A, Wolnicka-Głubisz A, Urbańska K, Stochel G, Macyk W. Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages. J Photochem Photobiol B 2008; 92: 54-8.
Janus AM, Faryna M, Haberko K, Rakowska A, Panz T. Chemical and microstructural characterization of natural hydroxyapatite derived from pig bones.
Microchimica Acta 2008; 161: 349-53.
Różanowski B, Burke J, Sarna T, Różanowska M. The pro-oxidant effects of interactions of ascorbate with photoexcited melanin fade away with aging of the
retina. Photochemistry and Photobiology 2008; 84: 658-70.
Różanowski B, Burke JM, Boulton ME, Sarna T, Różanowska M. Human RPE
melanosomes protect from photosensitized and iron-mediated oxidation but
become pro-oxidant in the presence of iron upon photodegradation. Invest
Ophthalmol Vis Sci 2008; 49: 2838-47.
Różanowski B, Cuenco J, Davies S, Shamsi FA, Żądło A, Dayhaw-Barker P,
Różanowska M, Sarna T, Boulton ME. The phototoxicity of aged human retinal melanosomes. Photochemistry and Photobiology 2008; 84: 650-7.
Wielgus AR, Sarna T. Ascorbate enhances photogeneration of hydrogen peroxide mediated by the iris melanin. Photochemistry and Photobiology 2008; 84:
683-91.
Wiśniewska A, Subczyński WK. The liquid-ordered phase in sphingomyelincholesterol membranes as detected by the discrimination by oxygen transport
(DOT) method. Cell Mol Biol Lett 2008; 13: 430-51.
Ye T, Pawlak A, Sarna T, Simon JD. Different molecular constituents in pheomelanin are responsible for emission, transient absorption and oxygen photoconsumption. Photochem Photobiol 2008; 84: 437-43.
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Zecca L, Casella L, Albertini A, Bellei C, Zucca FA, Engelen M, Żądło A, Szewczyk G, Zaręba M, Sarna T. Neuromelanin can protect against iron-mediated
oxidative damage in system modeling iron overload of brain aging and Parkinson's disease. J Neurochem 2008; 106: 1866-75.
Reviews
Hu DN, Simon JD, Sarna T. Role of ocular melanin in ophthalmic physiology
and pathology. Photochem. Photobiol. 2008, 84: 639-644.
Research grants
MNiSzW, No 2040/B/PO1/2007/33
from October 2007 till October 2010
Analysis of antioxidant properties of
plasmalogens in model systems.
Principal investigator: T. Sarna
MNiSzW, No N30108332/3232
from June 2007 till April 2010
Peroxidation of cardiolipin: the role in antiapoptotic cellular response to oxidative stress.
Principal investigator: W. Korytowski
NIH, USA, 1-RO1-HL085677-01A1
from May 2007 till April 2011
Role of Oxidized Cardiolipin Translocation in Oxidative Stress-Induced Apoptosis.
Principal investigator: W. Korytowski
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LABORATORY OF RADIOSPECTROSCOPY OF CANCER
AND RADIOBIOLOGY
Krystyna Urbańska (PhD, DSc)
Academic staff
Martyna Elas (PhD), Zenon Matuszak (PhD),
Beata Płonka (PhD), Przemyslaw M. Płonka
(PhD)
Supporting staff
Aleksandra Sierpniowska (DVM)
PhD students
Janusz Dąbrowski (MSc), Monika Jakubowska
(MSc), Dominika Michalczyk (MSc), Małgorzata Popik (MSc), Małgorzata Szczygieł (MSc)
MSc students
graduated in 2008
Biotechnology: Małgorzata Cichoń, Julia Minkiewicz, Maria Pohorecka
Biology: Anna Babina, Iwona Góra
Biophysics: Agata Górecka, Karolina Milowska
Chemistry: Kinga Gębołyś
Research focus
• Radiobiology – radiosensitization, the photodynamic therapy of cancer,
combined treatment of cancer in experimental in vitro and in vivo models, the biology of melanoma
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• The application of EPR in biomedicine, measurements of nitric oxide by
EPR, the role of nitric oxide in biology, bioethics
• Experimental trichology: hair cycle and its animal models, melanin and
pigmented cells, application of EPR spectroscopy in biomedicine, slime moulds and lower eucariota as alternative experimental models,
the semiotics of genetical information
• Biologically important donor-acceptor reactions involving free radicals,
including interaction between reactive oxygen and nitrogen species
with some antioxidant systems, radiation biophysics, and dynamic simulations of free radical reactions
• EPR oximetry, EPR imaging, hypoxia in tumors
Publications
Elas M, Bell R, Hleihel D, Barth ED, Mcfaul C, Haney CR, Bielanska J, Pustelny K, Ahn KH, Pelizzari CA, Kocherginsky M, Halpern HJ. Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly
correlates with tumor cure in FSA fibrosarcomas. International Journal of Radiation Oncology Biology Physics 2008; 71: 542-9.
Elas M, Bielanska J, Pustelny K, Płonka PM, Drelicharz L, Skorka T, Tyrankiewicz U, Wozniak M, Heinze-Paluchowska S, Walski M, Wojnar L, Fortin D,
Ventura-Clapier R, Chłopicki S. Detection of mitochondrial dysfunction by
EPR technique in mouse model of dilated cardiomyopathy. Free Radic Biol
Med 2008; 45: 321-8.
Grabacka M, Placha W, Urbańska K, Laidler P, Płonka PM, Reiss K. PPAR
gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91. Pigment Cell Melanoma Res
2008; 21: 388-96.
Jańczyk A, Wolnicka-Głubisz A, Urbańska K, Kisch H, Stochel G, Macyk W.
Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light. Free Radic Biol Med 2008; 44: 1120-30.
Janczyk A, Wolnicka-Głubisz A, Urbańska K, Stochel G, Macyk W. Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages. J Photochem Photobiol B 2008; 92: 54-8.
Krzywda A, Petelenz E, Michalczyk D, Płonka PM. Sclerotia of the acellular
(true) slime mould Fuligo septica as a model to study melanization and anabiosis. Cell Mol Biol Lett 2008; 13: 130-43.
Międzobrodzki J, Panz T, Płonka PM, Zając K, Dracz J, Pytel K, Mateuszuk L,
Chłopicki S. Platelets augment respiratory burst in neutrophils activated by
selected species of gram-positive or gram-negative bacteria. Folia Histochem
Cytobiol 2008; 46: 383-8.
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Szczygieł M, Urbańska K, Jurecka P, Stawoska I, Stochel G, Fiedor L. Central
metal determines pharmacokinetics of chlorophyll-derived xenobiotics. J Med
Chem 2008; 51: 4412-8.
Płonka PM, Michalczyk D, Popik M, Handjiski B, Paus R. Electron paramagnetic resonance (EPR) spectroscopy for investigating murine telogen skin after
spontaneous or depilation-induced hair growth. J Dermatol Sci 2008; 49: 227-40.
Research grants
KBN, No R05 043 03
from November 2007
till November 2010
Development of synthese technology and pharmaceutical form of new
potential photosensitizers (Opracowanie technologii syntezy oraz postaci
farmaceutycznej
nowych,
potencjalnych leków fotouczulających o szczególnych walorach terapeutycznych i społecznych).
Co-ordinator: Alicja Ratuszna
Principal investigator: Krystyna Urbańska
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OF
LABORATORY OF SPECTROSCOPIC METHODS
STUDYING BIOMOLECULES’ STRUCTURE AND FUNCTION
Wojciech Froncisz (PhD, DSc, Professor)
Academic staff
Małgorzata Dutka (PhD), Ryszard J. Gurbiel
(PhD, DSc), Bernard Korzeniewski (PhD,
DSc), Artur Osyczka (PhD, DSc), Janusz Pyka
(PhD), Marcin Sarewicz (PhD)
Supporting staff
Jerzy Kozioł (MSc, Eng), Tadeusz Oleś (MSc,
Eng)
PhD students
Arkadiusz Borek (MSc), Ewa Borkowska
(MSc), Ewelina Cieluch (MSc), Jarosław
Dzbęk (MSc), Marcin Sarewicz (MSc), Monika
Świerczek (MSc)
MSc students
graduated in 2008
Biotechnology: Joanna Śliwiak
Research focus
• Molecular bioenergetics: natural engineering of respiratory and photosynthetic chains and their role in maintaining cell homeostasis, molecular architecture of cofactor chains in the bioenergetic membrane,
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mechanisms of electron and proton transfers, heme proteins (cytochromes), iron-sulphur proteins, oxidoreductases (cytochrome bc complexes)
• The computer modelling of oxidative phosphorylation in isolated mitochondria, intact skeletal muscle and heart; regulation of ATP supply during an
increased energy demand; effect of low oxygen concentration on oxidative phosphorylation; effect of inborn enzyme deficiencies on oxidative phosphorylation, genesis of mitochondrial diseases; cybernetic definition of
life
• The development of EPR spectroscopic methods (saturation recovery
EPR, multiquantum EPR, EPR imaging, EPR dosimetry) and instrumentation (microwave resonators, microwave low noise sources, digital receivers, FM modulation) for biophysical studies; protein structure and
dynamics; functional magnetic resonance imaging
Publications
Borek A, Sarewicz M, Osyczka A. Movement of the iron-sulfur head domain of
cytochrome bc(1) transiently opens the catalytic Q(o) site for reaction with
oxygen. Biochemistry 2008; 47: 12365-70.
Dzbek J, Korzeniewski B. Control over the contribution of the mitochondrial
membrane potential (DeltaPsi) and proton gradient (DeltapH) to the protonmotive force (Deltap). In silico studies. J Biol Chem 2008; 283: 33232-9.
Froncisz W, Camenisch TG, Ratke JJ, Anderson JR, Subczynski WK, Strangeway RA, Sidabras JW, Hyde JS. Saturation recovery EPR and ELDOR at
W-band for spin labels. J Magn Reson 2008; 193: 297-304.
Korzeniewski B, Deschodt-Arsac V, Calmettes G, Franconi JM, Diolez P. Physiological heart activation by adrenaline involves parallel activation of ATP
usage and supply. Biochem J 2008; 413: 343-7.
Lee DW, Ozturk Y, Osyczka A, Cooley JW, Daldal F. Cytochrome bc1-cy fusion complexes reveal the distance constraints for functional electron transfer between photosynthesis components. J Biol Chem 2008; 283: 13973-82.
Ozturk Y, Lee DW, Mandaci S, Osyczka A, Prince RC, Daldal F. Soluble variants of Rhodobacter capsulatus membrane-anchored cytochrome cy are efficient photosynthetic electron carriers. J Biol Chem 2008; 283: 13964-72.
Sarewicz M, Borek A, Daldal F, Froncisz W, Osyczka A. Demonstration of
short-lived complexes of cytochrome c with cytochrome bc1 by EPR spectroscopy: implications for the mechanism of interprotein electron transfer. J Biol
Chem 2008; 283: 24826-36.
Sarewicz M, Szytula S, Dutka M, Osyczka A, Froncisz W. Estimation of binding parameters for the protein-protein interaction using a site-directed spin
labeling and EPR spectroscopy. Eur Biophys J 2008; 37: 483-93.
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Reviews
Zhang H, Chobot SE, Osyczka A, Wraight CA, Dutton PL, Moser CC. Quinone
and non-quinone redox couples in Complex III. J Bioenerg Biomembr 2008;
40: 493-9.
Research grants
The Wellcome Trust International
Senior Research Fellowship
from September 2006 till August 2011
Reversible energy coupling in ubiquinol – cytochrome c oxidoreductase engineering of cofactor
chains for radical and short-circuit
supression, molecular basis of adaptation and disease.
Principal investigator: A. Osyczka
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3.2. DEPARTMENT OF COMPUTATIONAL BIOPHYSICS
AND BIOINFORMATICS
Marta Pasenkiewicz-Gierula (PhD, DSc, Professor)
Academic staff
Piotr Liguziński (PhD), Michał Markiewicz
(MSc), Krzysztof Murzyn (PhD)
Supporting staff
Janusz Mordarski (MSc)
PhD students
Krzysztof Baczyński (MSc), Arkadiusz Maciejewski (MSc)
MSc students
graduated in 2008
Biophysics: Mateusz Sikora
Research focus
• The dynamic structure of lipid bilayers – how the molecular structure of
various lipid molecules influence the structural and dynamical properties of lipid bilayers
• The dupramolecular structure of the magainin pore as seen by molecular dynamics simulation
• Cytochrome c structure
• Bicelles and micelles
• Computational genomics
• Carotenoids in biological membranes
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• Piperidine local anesthetics action on biological membranes
• Lipid-protein interactions
• Non-steroidal anti-inflammatory drugs interaction with membranes
• Heavy water effects on a lipid bilayer
Publications
Bunker A, Mannisto P, St Pierre JF, Róg T, Pomorski P, Stimson L, Karttunen M. Molecular dynamics simulations of the enzyme catechol-O-methyltransferase: methodological issues. SAR QSAR Environ Res 2008; 19:
179-89.
Falck E, Róg T, Karttunen M, Vattulainen I. Lateral diffusion in lipid membranes
through collective flows. J Am Chem Soc 2008; 130: 44-5.
Martinez-Seara H, Róg T, Karttunen M, Reigada R, Vattulainen I. Influence of
cis double-bond parametrization on lipid membrane properties: How seemingly insignificant details in force-field change even qualitative trends. Journal
of Chemical Physics 2008; 129: 105103.
Martinez-Seara H, Róg T, Pasenkiewicz-Gierula M, Vattulainen I, Karttunen M,
Reigada R. Interplay of unsaturated phospholipids and cholesterol in membranes: Effect of the double-bond position. Biophysical Journal 2008; 95:
3295-305.
Poyry S, Róg T, Karttunen M, Vattulainen I. Significance of cholesterol methyl
groups. J Phys Chem B 2008; 112: 2922-9.
Róg T, Murzyn K, Karttunen M, Pasenkiewicz-Gierula M. Nonpolar interactions
between trans-membrane helical EGF peptide and phosphatidylcholines,
sphingomyelins and cholesterol. Molecular dynamics simulation studies.
J Pept Sci 2008; 14: 374-82.
Róg T, Stimson LM, Pasenkiewicz-Gierula M, Vattulainen I, Karttunen M.
Replacing the cholesterol hydroxyl group with the ketone group facilitates
sterol flip-flop and promotes membrane fluidity. J Phys Chem B 2008; 112:
1946-52.
Róg T, Vattulainen I, Jansen M, Ikonen E, Karttunen M. Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated
lipid bilayers. J Chem Phys 2008; 129: 154508.
Zhao W, Róg T, Gurtovenko AA, Vattulainen I, Karttunen M. Role of phosphatidylglycerols in the stability of bacterial membranes. Biochimie 2008; 90:
930-8.
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Research grants
MNiSW, No PBZ-MNiI-1/1/2005
from November 2005 till November 2009
New pharmaceutics with particular therapeutic and social merits:
Prediction of molecular mechanisms for membrane active antibacterial drugs.
Principal investigator: M. PasenkiewiczGierula
6th Framework Programme
No MTKD-CT-2006-042586
from November 2006 till December 2010
Functional analysis of new acute
phase proteins, ACUP, Marie Curie Host Fellowships for the Transfer of Knowledge.
Principal investigator: H. Rokita
Investigator: K. Murzyn
23
3.3. DEPARTMENT OF ANALYTICAL BIOCHEMISTRY
Adam Dubin (PhD, DSc, Professor)
Academic staff
Emilia Bonar (PhD), Anna Gołda (MSc), Ibeth
Guevara-Lora (PhD), Andrzej Kozik (PhD,
DSc, Professor), Paweł Mak (PhD), Maria Rąpała-Kozik (PhD), Benedykt Władyka (PhD)
Supporting staff
Oliwia Bocheńska (MSc), Marta Kujda (MSc)
PhD students
Anna Barbasz (MSc), Aleksandra Kałużny
(MSc), Justyna Karkowska-Kuleta (MSc), Ewa
Kowalska (MSc), Katarzyna Pustelny (MSc),
Justyna Steć-Niemczyk (MSc)
MSc students
graduated in 2008
Biotechnology: Michał Biśta, Kaja Kowalska
Biology: Marta Kujda, Magda Majkucińska
Chemistry: Magdalena Florkowska, Oliwia Bocheńska
Research focus
• The biochemical and structural characterisation of bacterial virulence
factors, mainly proteolytic enzymes and their protein inhibitors from
S. aureus
25
• Antibacterial peptides: isolation, purification, amino acid sequence and
biochemical characterisation
• Continuation studies on hemocidins – antibacterial peptide fragments
of hemoglobin
• Macromolecular interactions in the kinin-generating systems and their
modifications in the inflammatory foci
• The biochemistry of oxidative stress
• The biochemistry of vitamins and coenzymes
• The structural and enzymatic characterization of proteins engaged in
thiamine biosynthesis processes in plants, bacteria and yeast
• The influence of bacterial and fungal infections on the activity and functions of the kinin-generating system and blood coagulation cascade
• The expression of kinin receptors genes in the regulation of inflammation
Publications
Barbasz A, Guevara-Lora I, Rapala-Kozik M, Kozik A. Kininogen binding
to the surfaces of macrophages. Int. Immunopharmacol 2008; 8: 211216.
Dubin G, Stec-Niemczyk J, Kisielewska M, Pustelny K, Popowicz G.M, Bista M,
Kantyka T, Boulware KT, Stennicke HR, Czarna A, Phopaisarn M, Dauugherty PS, Thogersen IB, Enghild JJ, Thornberry N, Dubin A, Potempa J. Enzymatic activity of the Staphylococcus aureus SplB serine proteinase is
induced by substrates containing the sequence Trp-Glu-Leu-Gln. J Mol Biol
2008; 379: 343-356.
Elas M, Bell R, Hleihel D, Barth ED, McFaul C, Haney CR, Bielanska J, Pustelny K, Ahn KH, Pelizzari CA, Kocherginsky M, Halpern HJ. Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly
correlates with tumor cure in FSa fibrosarcomas. Inter. J Rad Oncol Biol Phys
2008; 71: 542-549.
Elas M, Bielanska J, Pustelny K, Plonka PM, Drelicharz L, Skorka T, Tyrankiewicz U, Wozniak M, Heinze-Paluchowska S, Walski M, Wojnar L, Fortin D,
Ventura-Clapier R, Chlopicki S. Detection of mitochondrial dysfunction by
EPR technique in mouse model of dilated cardiomyopathy. Free Radical
Biol. Med 2008; 45: 321-328.
Mak P, Maszewska A, Rozalska M. (2008) The amino acid sequences and activities of synergistic hemolysins from Staphylococcus Cohnie. FEMS Microbiol Lett 287: 230-235.
Rapala-Kozik M, Karkowska J, Jacher A, Golda A, Barbasz A, Guevara-Lora I,
26
Kozik A. Kininogen adsorption to the cell surface of Candida spp. Int Immunopharmacol 2008; 8: 237-241.
Rapala-Kozik M, Kowalska E, Ostrowska K. Modulation of thiamine metabolism
in Zea mays seedlings under conditions of abiotic stress. J Exp Bot 2008;
59: 4133-4143.
Sabat A, Wladyka B, Kosowska-Shick K, Grundmann H, Appelbaum PC, Kowal J, Dubin A, Hryniewicz W. Polymorphism, genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureus
strains. BMC Microbiology 2008; 8:129-140.
Wicherek L, Basta P, Galazka K, Mak P, Dancewicz L, Kalinka J. RCAS1 decidual immunoreactivity and RCAS1 serum level during cesarean section regarding labor progression. Am J Reprod Immunol 2008; 59: 152-158.
Władyka B, Bista M, Sabat AJ, Bonar E, Grzeszczuk S, Hryniewicz W, Dubin A. A novel member of the thermolysis family, clonning aand biochemical
chracterisiation of metalloproteoase from Staphylococcus pseudintermedius.
Acta Biochim Polon 2008; 55: 525-536.
Reviews
Kowalska E, Kozik A. The genes and enzymes involved in the biosynthesis of
thiamin and thiamin diphosphate in yeasts. Cell Mol Biol Lett 2008; 13: 271282.
Mak P. Hemocidins in a functional and structural context of human antimicrobial peptides. Front Biosci 2008; 13: 6859-6871.
Wladyka B, Pustelny K. Regulation of bacterial proteases activity. Cell Mol Biol
Lett 2008; 13: 212-229.
Research grants
MNiI, No 2 P04C 035 29
The binding and activation of kinin
producing systems on cell surfaces.
Principal investigator: A. Kozik
MNiSW, No N301 067 31/2018,
Modification of adhesion processes in the cells involved in blood clothing in inflammation under
influence of some products of the
activation of plasma kinin-generating system.
Principal investigator: I. Guevara-Lora
27
MiSzW No N N 302 1307 34
from May 2008 till May 2011
Staphylococcal plasmid pCH-91 as
a carrier of virulence factors and potential tool for efficient production
of recombinant proteins.
Principal investigator: A. Dubin
3.4. DEPARTMENT OF CELLULAR BIOCHEMISTRY
Joanna Bereta (PhD, DSc)
Academic staff
Monika Bzowska (PhD), Amalia Guzdek (PhD,
DSc), Jolanta Jura (PhD, DSc), Aneta Kasza
(PhD), Aleksander Koj (MD, DSc, Professor
Emeritus), Paulina Węgrzyn (PhD), Adrian Zarębski (PhD)
Supporting staff
Halszka Kasprzyk, Krystyna Stalińska (MSc),
Maria Weigt-Wadas
PhD students
Paulina Chorobik (MSc), Stanisław Malicki
(MSc), Renata Mężyk-Kopeć (MSc), Danuta
Mizgalska (MSc), Paulina Wyrzykowska, Maja
Sochalska (MSc)
MSc students
graduated in 2008
Biotechnology: Aleksandra Balwierz, Anna Bartosik, Wojciech Gałan, Katarzyna Glanowska,
Agata Oruba, Łukasz Skalniak, Dominika Śliwa, Kornel Gołębiewski
Research focus
• The intracellular signalling and regulation of the expression of genes involved in cell response to proinflammatory cytokines and growth factors
29
• The identification and characterization of new acute phase proteins
• Studies on the interplay between cytokines and proteases during inflammation
• The antii-nflammatory properties of plant-derived compounds – potential therapeutics
Publications
Jura J, Węgrzyn P, Korostyński M, Guzik K, Oczko-Wojciechowska M, Jarząb M, Kowalska M, Piechota M, Przewłocki R, Koj A. Identification of
interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays. Biochim Biophys Acta 2008;
1779: 383-9.
Opiela J, Kątska-Książkiewicz L, Lipiński D, Słomski R, Bzowska M, Ryńska B. Interactions among activity of glucose-6-phosphate dehydrogenase
in immature oocytes, expression of apoptosis-related genes Bcl-2 and
Bax, and developmental competence following IVP in cattle. Theriogenology 2008; 69: 546-55.
Research grants
MNiSW, No 0463/P04/2005/29
from November 2005 till October 2008
Identification of early-response genes regulated by Elk-1 transcription factor in response to MA P
kinases’ activation.
Principal investigator: A. Kasza
MNiSW, No 3144/B/P01/2007/33
Regulation of ADAM17 expression
and modulation of its activity in inflammation and cancer development.
Principal investigator: J. Bereta
MNiSW, No 63/6PR UE/2007/7
phase proteins.
30
MNiSW, No 339/6PR-UE/2007/7
Molecular pathways underlying decreased beta cell mass in diabetes mellitus.
Principal investigator: J. Jura
MNiSW, No 0603/B/P01/2008/34
from May 2008 till February 2010
Attenuation of Salmonella typhimurium by overexpression of endogenous protein SipB.
Principal investigator: J. Bereta
6th EC Framework Programme
No MTKD-CT-2006-042586,
ACUP, 42586
phase proteins.
6th EC Framework Programme
No LSHM-CT-2006-036903
Molecular pathways underlying decreased beta cell mass in diabetes mellitus.
MNiSW, No 3361N-COST/2008/O
from November 2008 till June 2011
The role and the regulation of
MCPiP gene expression in metabolic syndrome development.
31
3.5. DEPARTMENT OF PHYSICAL BIOCHEMISTRY
Marta Dziedzicka-Wasylewska (PhD, DSc,
Professor)
Academic staff
Piotr Bonarek (PhD), Ewelina Fic (PhD), Andrzej Górecki (PhD), Sylwia Kędracka-Krok
(PhD), Agnieszka Polit (PhD), Magdalena
Tworzydło (PhD)
Supporting staff
Czesława Mądry
PhD students
Ewa Błasiak (Msc), Filip Gołębiowski (Msc),
Sylwia Łukasiewicz (Msc)
MSc students
graduated in 2008
Biotechnology:
Marcin
Cieślik,
Dominika
Gruszka, Marcin Jaciuk, Urszula Jankowska,
Aleksandra Kałużny, Lucyna Ślusarz, Katarzyna
Zabłocka, Karolina Zielińska
Research focus
• The kinetic, thermodynamic and structural aspects of protein-protein,
protein-DNA and protein-ligand interactions
• The influence of antidepressant drugs on proteins profile in rat brains
– a proteomic approach
• The interactions of the human transcription factor YY1 with DNA promoter sequences and TFIIB protein
33
• Applying fluorescence methods to study the homo and heterodimerization of dopamine and serotonine receptors and mechanisms of G-protein subunits and dopamine receptors interactions
Publications
Bonarek P, Kedracka-Krok S, Kepys B, Wasylewski Z. Quantitative analysis of the
ternary complex of RNA polymerase, cyclic AMP receptor protein and DNA by
fluorescence anisotropy measurements. Acta Biochim Pol 2008; 55: 537-547.
Faron-Górecka A, Górecki A, Kuśmider M, Wasylewski Z, Dziedzicka-Wasylewska M. The role of D1-D2 receptor hetero-dimerization in the mechanism of
action of clozapine. Eur Neuropsychopharmacol 2008; 18: 682-691.
Reviews
Dziedzicka-Wasylewska M, Faron-Górecka A, Górecki A, Kuśmider M. Mechanism of action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization – a working hypothesis. Pharmacol Rep 2008; 60: 581-587.
Grymek K, Gaska M, Łukasiewicz S, Górecki A, Dziedzicka-Wasylewska M.
Fluorescence studies of G-protein coupled receptors oligomerization. Postępy Biochemii 2008; 54: 431-437.
Research grants
KBN, No 2 P04A/070/20
Studies of molecular mechanisms of
human dopamine D1 and D2 receptor interactions in model systems.
Principal investigator: A. Polit
KBN, No 3128 P01 2006 31
from August 2006 till August 2009
Studies of molecular mechanism
of interactions between human
transcription factor Yin Yang 1,
TFIIB and DNA.
Principal investigator: A. Górecki
PBZ 0011 (as a part of project
No 10 0-PBZ-MNiI-2/1/2005)
from December 2006 till December 2009
Applying Proteomics to describe
molecular mechanisms of action
of antidepressant drugs.
Principal investigator: S. Kędracka-Krok.
3.6. DEPARTMENT OF GENERAL BIOCHEMISTRY
Andrzej Klein (PhD, DSc, Professor)
Academic staff
Maria Kapiszewska (PhD, DSc, Prof.), Anna
Kordowiak (PhD, DSc, Prof.), Bohdan Turyna
(PhD)
Supporting staff
Maria Kawecka (MSc), Alicja Strzelbicka (MSc)
PhD students
Przemysław Holko (MSc), Joanna Kisielewska
(MSc), Janusz Ligęza (MSc), Grzegorz Zając
(MSc)
MSc students
graduated in 2008
Biotechnology: Kamil Faff, Marcin Kaczkowski,
Aleksandra Słomińska
Biology: Katarzyna Dziubek, Marcelina Miazga,
Iwona Mierzwa, Lucyna Nielipińska
Research focus
• The mechanisms of autocrine cell growth regulation
• The influence of protein kinase inhibitors on neoplastic cell growth
• The influence of diet and genetic polymorphisms on genomic stability
• The anti-proliferative activities of vanadium compounds
35
Publications
Holko P, Ligeza J, Kisielewska J, Kordowiak AM, Klein A. The effect of vanadyl
sulphate (VOSO4) on autocrine growth of human epithelial cancer cell lines.
Pol J Pathol 2008; 59: 3-8.
Jurek A, Turyna B, Kubit P, Klein A. The ability of HDL to inhibit VCAM-1
expression and oxidized LDL uptake is impaired in renal patients. Clin Biochem 2008; 41: 1015-8.
Kisielewska J, Ligeza J, Klein A. The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells
(DU145). Folia Histochem Cytobiol 2008; 46: 185-91.
Klein A, Holko P, Ligeza J, Kordowiak AM. Sodium orthovanadate affects
growth of some human epithelial cancer cells (A549, HTB44, DU145). Folia
Biol (Krakow) 2008; 56: 115-21.
Research grants
KBN 2 P05A/2006/162 30
from 2006 till 2009
The investigations of DNA demage, apoptosis and proliferation of
spleen and bone marrow cells of
rats with promyelocyte leukemia
after treatment with anti- and prooxidative compounds.
Principal investigator: M. Kapiszewska
3.7. DEPARTMENT OF CELL BIOLOGY
Head of the department
Zbigniew Madeja (PhD, DSc)
Acaemic staff
Jarosław Czyż (PhD, DSc), Justyna
Drukała (PhD), Włodzimierz Korohoda
(PhD, DSc, Professor Emeritus), Marta
Michalik (PhD), Jolanta Sroka (PhD), Anna
Wilk (PhD)
Supporting staff
Lidia Ciastoń (MSc), Jadwiga Golda (MSc),
Elżbieta Sater, Maria Starostka-Wróbel
(MSc, Eng)
PhD students
Iga Bechyne (MSc), Monika Rak (MSc), Ewa
Wybieralska (Msc)
MSc students
graduated in 2008
Biotechnology: Marcin Czepiel, Karolina
Janeczek, Szymon Oleksy, Michał Pytel, Magdalena Stawiarska
Biology: Justyna Antonik, Ewa Czekańska, Karolina Ferlej, Agnieszka Kalita, Aneta Kantor,
Małgorzata Kościółek, Magdalena Krakowiak,
Aleksandra Lawera, Monika Rak, Igor
Różański, Anna Włodarczyk
37
Research focus
• Morphology, motility, and cell-cell interactions among tumour cells and normal tissue cells
• Galvanotaxis, chemotaxis and contact guidance of various cells (unicellular organisms: Amoeba proteus, Dictyostelium discoideum, human and
animal tissue cells)
• Research into the acceleration of wound healing; mass cultures of human
skin keratinocytes, fibroblasts and melanocytes
• The effect of organometalic compounds on tissue cells in culture
• The application of electrochemistry to cell biology (elctrofusion, electroporation, cell electrophoretic separation)
• The effect of the redox state of the cell and thioredoxin reductase activity
on the motility of animal cells
• Phenotypic transitions in cancer cell populations
• Analysis of the role of cell-substratum and cell-to-cell interactions in the regulation of cell physiology with special emphasis on the mutual interactions between factors determining cell adhesion (integrins, cadherins)
and intercellular communication (connexins)
Publications
Czernik M, Sroka J, Madeja Z, Czyż J. Apigenin inhibits growth and motility but
increases gap junctional coupling intensity in rat prostate carcinoma (MAT-LyLu) cell populations. Cell Mol Biol Lett 2008; 13: 327-38.
Daniel-Wojcik A, Misztal K, Bechyne I, Sroka J, Miekus K, Madeja Z, Czyż J.
Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations. Int J Oncol 2008; 33: 309-15.
Galanty A, Michalik M, Sedek L, Podolak I. The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells. Cell Mol Biol Lett 2008; 13: 585-98.
Krzysiek-Mączka G, Korohoda W. Surface anisotropy orients cell divisions in
contact guided cells. Folia Biol-Krakow 2008; 56: 13-9.
Siddiqui K, Del Valle L, Morellet N, Cui J, Ghafouri M, Mukerjee R, Urbanska K,
Fan S, Pattillo CB, Deshmane SL, Kiani MF, Ansari R, Khalili K, Roques BP,
Reiss K, Bouaziz S, Amini S, Srinivasan A, Sawaya BE. Molecular mimicry in
inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin. Oncogene 2008; 27: 32-43.
Sroka J, Czyż J, Wojewoda M, Madeja Z. The inhibitory effect of diphenyltin on
gap junctional intercellular communication in HEK-293 cells is reduced by
thioredoxin reductase 1. Toxicol Lett 2008; 183: 45-51.
38
Sroka J, Włosiak P, Wilk A, Antonik J, Czyż J, Madeja Z. The effect of tributyltin
on human eosinophylic leukemia EoL-1 cells. Cell Mol Biol Lett 2008; 13: 67-73.
Urbańska K, Pannizzo P, Grabacka M, Croul S, Del Valle L, Khalili K, Reiss K.
Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines. Int J Cancer 2008; 123: 1015-24.
Waligórska A, Wianecka-Skoczeń M, Korohoda W. Reversible inhibition of movement in the amoebae Dictyostelium discoideum and its effect on chemoattractant recognition. Folia Biol (Krakow) 2008; 56: 123-31.
Wilk A, Urbanska K, Woolley DE, Korohoda W. Cell separation with horizontal
cell electrophoresis under near-isopycnic conditions on a "density cushion".
Cell Mol Biol Lett 2008; 13: 366-74.
Wybieralska E, Koza M, Sroka J, Czyż J, Madeja Z. Ascorbic acid inhibits the migration of Walker 256 carcinosarcoma cells. Cell Mol Biol Lett 2008; 13: 103-11.
Reviews
Czyż J. The stage-specific function of gap junctions during tumourigenesis.
Cell Mol Biol Lett 2008; 13: 92-102.
Korohoda W, Wilk A. Cell electrophoresis - a method for cell separation and research into cell surface properties. Cell Mol Biol Lett 2008; 13: 312-26.
Research grants
KBN, No 2P04C 008 28
The effect of cell-to-cell contacts
and redox state on the motile activity of animal cells.
Principal investigator: Z. Madeja
KBN, No 2P04C 125 29
Analysis of the role of cell surface
complex and the processes involved in the determination of tumour
cell invasiveness and merastasis.
Principal investigator: J. Czyż
MNiSW, N N305 336434
The effect of some organometallic
compounds on membrane channels (ion channels and gap junctions) of some types of cells.
Principal investigator: S. Przestalski
39
3.8. DEPARTMENT OF IMMUNOLOGY
Juliusz Pryjma (MD, PhD, DSc, Professor)
Academic staff
Małgorzata Bzowska (PhD), Joanna Cichy
(PhD, DSc), Krzysztof Guzik (PhD), Joanna
Skrzeczyńska-Moncznik (PhD)
Supporting staff
Maria Filipowicz, Ewa Marewicz (MSc), Danuta Szmyd (Eng)
PhD students
Jerzy Frączek (MSc), Grzegorz Friedlein
(MSc), Tomasz Herjan (MSc), Paulina Kulig
(MSc), Tomasz Mikołajczyk (MSc), Karol
Szczepanek (MSc)
MSc students
graduated in 2008
Biotechnology: Anna Buchała, Katarzyna Hanzelka, Anna Staniszewska, Anna Stefańska,
Anna Zając
Research focus
• Monocyte/macrophage apoptosis after phagocytosis of S. aureus
• Interaction between immune cells and apoptotic cells
• The role of modified low-density lipoproteins on IL-10 production by monocytes/macrophages
41
• The role of S. aureus in the modification of engulfment synapse – the
fates of engulfed bacterium, phagocyte and the reaction of the immune
system
• The role of proteases in the regulation of chemerin pDC-specific chemotactic factor
• The role of ADAM17 in immune response
Publications
Balwierz A, Czech U, Polus A, Filipkowski RK, Mioduszewska B, Prószynski T,
Kołodziejczyk P, Skrzeczyńska-Moncznik J, Dudek W, Kaczmarek L, Kulig J,
Pryjma J, Dembińska-Kieć A. Human adipose tissue stromal vascular fraction cells
differentiate depending on distinct types of media. Cell Prolif 2008; 41: 441-59.
Frączek J, Kim TW, Xiao H, Yao J, Wen Q, Li Y, Casanova JL, Pryjma J, Li X.
The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation. J Biol Chem 2008; 283: 31697-705.
Homa J, Bzowska M, Klimek M, Płytycz B. Flow cytometric quantification of proliferating coelomocytes non-invasively retrieved from the earthworm,
Dendrobaena veneta. Dev Comp Immunol 2008; 32: 9-14.
Jura J, Węgrzyn P, Korostynski M, Guzik K, Oczko-Wojciechowska M, Jarząb M,
Kowalska M, Piechota M, Przewłocki R, Koj A. Identification of interleukin-1
and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays. Biochim Biophys Acta 2008; 1779: 383-9.
Kubica M, Guzik K, Kozieł J, Zarębski M, Richter W, Gajkowska B, Golda A,
Maciąg-Gudowska A, Brix K, Shaw L, Foster T, Potempa J. A potential new
pathway for Staphylococcus aureus dissemination: the silent survival of
S. aureus phagocytosed by human monocyte-derived macrophages. PLoS
One 2008; 3: e1409.
Papież MA, Cierniak A, Krzyściak W, Bzowska M, Taha HM, Józkowicz A,
Piskuła M. The changes of antioxidant defense system caused by quercetin
administration do not lead to DNA damage and apoptosis in the spleen and
bone marrow cells of rats. Food Chem Toxicol 2008; 46: 3053-8.
Skrzeczyńska-Moncznik J, Bzowska M, Loseke S, Grage-Griebenow E, Zembala M, Pryjma J. Peripheral blood CD14high CD16+ monocytes are main
producers of IL-10. Scand J Immunol 2008; 67: 152-9.
Surdacki A, Marewicz E, Wieteska E, Szastak G, Rakowski T, Wieczorek-Surdacka E, Dudek D, Pryjma J, Dubiel JS. Association between endothelial progenitor cell depletion in blood and mild-to-moderate renal insufficiency in
stable angina. Nephrol Dial Transplant 2008; 23: 2265-73.
42
Szczepanek K, Kieda C, Cichy J. Differential binding of hyaluronan on the surface of tissue-specific endothelial cell lines. Acta Biochim Pol 2008; 55: 35-42.
Reviews
Guzik, K, Potempa, J. Friendly fire against neutrophils: proteolytic enzymes confuse the recognition of apoptotic cells by macrophages. Biochimie 90; 2: 405-15.
Research grants
MNiSW, No PB 2178/B/PO1/2008/34
Role of proteases in regulation of
chemerin pDC-specific chemotactic factor.
Principal investigator: J. Cichy
Fogarty International Research Collaboration Award, No 1 R03 TW007174
Immunomodulatory role of proteases.
from July 2005 till June 2008
MNiSW, No PB 2178/B/PO1/2008/34
Apoptosis of macrophages after
phagocytosis of Stapylococcus aureus or culture supernatants.
Principal investigator: J. Pryjma
MNiSW, No PB 2919/B/PO1/2008/34
The role of modified low-density lipoprotein in regulation of IL-10 production by monocytes/macrophages.
Principal investigator: M. Bzowska
MNiSW, No PB 2178/B/PO1/2008/34
Modification of engulfment synapse by Staphylococcus aureus as
a new strategy of pathogenicity determining the fates of engulfed bacterium,
phagocyte,
and
the
reaction of immune system.
Principal investigator: K. Guzik
MNiSW, No PB 0036/B/PO1/2008/35
Role of ADAM17 in immune response.
43
3.9. DEPARTMENT OF MICROBIOLOGY
Jan Potempa (PhD, DSc, Professor)
Academic staff
Grzegorz Dubin (PhD), Joanna Kozieł (PhD),
Katarzyna Maresz (PhD), Jacek Międzobrodzki
(PhD, DSc), Krzysztof Pyrć (PhD), Kinga Wójcik (PhD)
Supporting staff
Magdalena Nowak (MSc), Dorota Panek, Aneta
Sroka (MSc), Jadwiga Sukiennik (MSc), Borys
Szmigielski (MSc)
PhD students
Bartosz Dudek (MSc), Wojciech Gałan (MSc),
Anna Golda (MSc), Tomasz Kantyka (MSc),
Abdulkarim Karim (MSc), Magdalena Kulczycka (MSc), Agnieszka Maciąg (MSc),
Michał Potempa (MSc), Jan Smagur (MSc),
Katarzyna Warzonek (MSc), Michał Zdżalik
MSc students
graduated in 2008
Biotechnology: Izabela Baster, Paweł Buda,
Anna Chałupka, Kuba Iwanowicz, Mirosław
Książek, Katarzyna Tarnawska, Paulina Wochal
Biology: Magdalena Flis, Agnieszka Wójcik
Biology-geography: Klaudia Polakowska
45
Research focus
• The structure and function of the proteolytic enzymes of bacterial
pathogens including Staphylococcus aureus, Porphyromonas
gingivalis, Prevotella intermedia and Tannerella forsythia
• In vivo and in vitro studies of bacteria interaction with cells of innate
immunity
• The intracellular survival of S. aureus in macrophages
• A novel protein secretion system of periodontal pathogens (PerioGate,
T9SS)
• The role of bacterial proteases as virulence factors
• New diagnostic tools for human coronavirus-related respiratory
infections
• The role of bacterial co-infection on pathology of viral infections
Publications
Beaufort N, Wojciechowski P, Sommerhoff CP, Szmyd G, Dubin G, Eick S,
Kellermann J, Schmitt M, Potempa J, Magdolen V. The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin. Biochem J
2008; 410: 157-65.
Calander AM, Dubin G, Potempa J, Tarkowski A. Staphylococcus aureus infection triggers production of neutralizing, V8 protease-specific antibodies.
FEMS Immunol Med Microbiol 2008; 52: 267-72.
de Vries M, Pyrć K, Berkhout R, Vermeulen-Oost W, Dijkman R, Jebbink MF,
Bruisten S, Berkhout B, van der Hoek L. Human parechovirus type 1, 3, 4, 5,
and 6 detection in picornavirus cultures. J Clin Microbiol 2008; 46: 759-62.
Dijkman R, Jebbink MF, El Idrissi NB, Pyrć K, Muller MA, Kuijpers TW, Zaaijer
HL, van der Hoek L. Human coronavirus NL63 and 229E seroconversion in
children. J Clin Microbiol 2008; 46: 2368-73.
Dubin G, Stec-Niemczyk J, Kisielewska M, Pustelny K, Popowicz GM, Bista M,
Kantyka T, Boulware KT, Stennicke HR, Czarna A, Phopaisarn M, Daugherty
PS, Thogersen IB, Enghild JJ, Thornberry N, Dubin A, Potempa J. Enzymatic
activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln. J Mol Biol 2008; 379: 34356.
Hannes B, Vieillard J, Chakra EB, Mazurczyk R, Mansfield CD, Potempa J,
Krawczyk S, Cabrera M. The etching of glass patterned by microcontact printing with application to microfluidics and electrophoresis. Sensor Actuat BChem 2008; 129: 255-62.
46
Josefsson E, Kubica M, Mydel P, Potempa J, Tarkowski A. In vivo sortase A
and clumping factor A mRNA expression during Staphylococcus aureus infection. Microbial Pathogenesis 2008; 44: 103-10.
Kedzierska A, Kapinska-Mrowiecka M, Czubak-Macugowska M, Wójcik K, Kedzierska J. Susceptibility testing and resistance phenotype detection in Staphylococcus aureus strains isolated from patients with atopic dermatitis, with apparent
and recurrent skin colonization. Br J Dermatol 2008; 159: 1290-9.
Kozieł J, Maciag-Gudowska A, Potempa J. Staphylococcus aureus as an intracellular pathogen of immunological cells. Postepy Mikrobiologii 2008; 47:
393-9.
Kubica M, Guzik K, Kozieł J, Zarębski M, Richter W, Gajkowska B, Golda A,
Maciąg-Gudowska A, Brix K, Shaw L, Foster T, Potempa J. A potential new
pathway for Staphylococcus aureus dissemination: the silent survival of
S. aureus phagocytosed by human monocyte-derived macrophages. PLoS
One 2008; 3: e1409.
Lushchak V, Abrat O, Międzobrodzki J, Semchyshyn H. Pdr12p-dependent and
-independent fluorescein extrusion from baker's yeast cells. Acta Biochim Pol
2008; 55: 595-601.
Mallorqui-Fernandez N, Manandhar SP, Mallorqui-Fernandez G, Uson I,
Wawrzonek K, Kantyka T, Sola M, Thogersen IB, Enghild JJ, Potempa J,
Gomis-Ruth FX. A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. J Biol Chem 2008; 283:
2871-82.
Międzobrodzki J, Panz T, Płonka PM, Zając K, Dracz J, Pytel K, Mateuszuk L,
Chłopicki S. Platelets augment respiratory burst in neutrophils activated by
selected species of gram-positive or gram-negative bacteria. Folia Histochem
Cytobiol 2008; 46: 383-8.
Nilsson M, Wasylik S, Morgelin M, Olin AI, Meijers JC, Derksen RH, de Groot
PG, Herwald H. The antibacterial activity of peptides derived from human
beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes. Mol Microbiol 2008; 67: 482-92.
Noack B, Gorgens H, Schacher B, Pukło M, Eickholz P, Hoffmann T, Schackert
HK. Functional Cathepsin C mutations cause different Papillon-Lefevre syndrome phenotypes. J Clin Periodontol 2008; 35: 311-6.
Olczak T, Sroka A, Potempa J, Olczak M. Porphyromonas gingivalis HmuY and
HmuR: further characterization of a novel mechanism of heme utilization.
Arch Microbiol 2008; 189: 197-210.
Potempa M, Potempa J, Okrój M, Popadiak K, Eick S, Nguyen KA, Riesbeck K,
Blom AM. Binding of complement inhibitor C4b-binding protein contributes to
serum resistance of Porphyromonas gingivalis. J Immunol 2008; 181: 5537-44.
47
Pukło M, Guentsch A, Hiemstra PS, Eick S, Potempa J. Analysis of neutrophilderived antimicrobial peptides in gingival crevicular fluid suggests importance
of cathelicidin LL-37 in the innate immune response against periodontogenic
bacteria. Oral Microbiol Immunol 2008; 23: 328-35.
Rydengard V, Shannon O, Lundqvist K, Kacprzyk L, Chalupka A, Olsson AK,
Morgelin M, Jahnen-Dechent W, Malmsten M, Schmidtchen A. Histidine-rich
glycoprotein protects from systemic Candida infection. PLoS Pathog 2008; 4:
e1000116.
Smalley JW, Birss AJ, Szmigielski B, Potempa J. Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen
Porphyromonas gingivalis. Biol Chem 2008; 389: 1235-8.
Uehara A, Imamura T, Potempa J, Travis J, Takada H. Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and
NOD1/2 ligands in human monocytic cells. Cell Microbiol 2008; 10: 1181-9.
Uehara A, Naito M, Imamura T, Potempa J, Travis J, Nakayama K, Takada H.
Dual regulation of interleukin-8 production in human oral epithelial cells upon
stimulation with gingipains from Porphyromonas gingivalis. J Med Microbiol
2008; 57: 500-7.
Reviews
Guzik K, Potempa J. Friendly fire against neutrophils: proteolytic enzymes confuse the recognition of apoptotic cells by macrophages. Biochimie 2008; 90:
405-15.
Golda A, Pyrć K. Recent antiviral strategies against human coronavirus-related
respiratory illnesses. Current Opinion in Pulmonary Medicine 2008; 14: 248-53.
Kozieł J, Maciąg-Gudowska A, Potempa J. Staphylococcus aureus as an intracellular pathogen of immunological cells. Postepy Mikrobiologii 2008; 47: 393-9.
Międzobrodzki J, Malachowa N, Markiewski T, Białecka A, Kasprowicz A. Differentiation of Staphylococcus aureus isolates based on phenotypical characters. Postepy Higieny I Medycyny Doswiadczalnej 2008; 62: 322-7
Pyrć K. Human coronavirus NL63 – molecular characteristics and clinical image. Postepy Mikrobiologii 2008; 47: 257-62.
Research grants
MNiSW, No 1642/B/P01/2008/35
from August 2008 till August 2011
The role of dental plaque bacterial
proteases in periodontitis.
Principal investigator: J. Potempa
48
KBN, No 2 P04A 049 28
Molecular analysis of macrophages to intracellular growth of Staphylococcus aureus.
Principal investigator: J. Kozieł
FNP Homing
from December 2008 till December 2010
Influence of extracellular bacterial
proteases on viral infection.
Principal investigator: K. Pyrć
49
3.10. DEPARTMENT OF MEDICAL BIOTECHNOLOGY
Józef Dulak (PhD, DSc, Professor)
Academic staff
Alicja Józkowicz (PhD, DSc), Agnieszka
Łoboda (PhD), Agnieszka Jaźwa (PhD)
Supporting staff
Agnieszka Andrychowicz-Róg (MSc), Agnieszka
Cader (MSc)
PhD students
Sławomir Gołda (MSc), Anna Grochot-Przęczek
(MSc), Jerzy Kotlinowski (MSc), Andrzej
Rutkowski (MSc), Magdalena Kozakowska
(MSc), Hevidar Mustafa Taha (MSc), Halina
Waś (MSc), Urszula Florczyk (MSc)
MSc students
graduated in 2008
Biotechnology:
Radosław
Lach,
Marcin
Maćkowski, Anna Rehahn, Weronika Sikora,
Klaudia Skrzypek, Małgorzata Sokołowska,
Anna Stachurska, Anna Strzępa, Magdalena
Tertil
Research focus
• Medical biotechnology: gene therapy
• Stem cells biology and cell therapy
51
• The molecular mechanisms of angiogenesis
• The molecular mechanisms of tumor growth, angiogenesis and metastasis
• The role of heme oxygenase-1 in inflammation and angiogenesis: cardiovascular diseases, wound healing, kidney diseases
• The role of hypoxia in the regulation of gene expression in angiogenesis and inflammation
• Pharmacological modulation of inflammation and angiogenesis
Publications
Almolki A, Guenegou A, Gołda S, Boyer L, Benallaoua M, Amara N, Bachoual R, Martin C, Rannou F, Lanone S, Dulak J, Burgel PR, El-Benna J, Leynaert B, Aubier M, Boczkowski J. Heme oxygenase-1 prevents airway mucus
hypersecretion induced by cigarette smoke in rodents and humans. Am J
Pathol 2008; 173: 981-92.
Boesch-Saadatmandi C, Łoboda A, Józkowicz A, Huebbe P, Blank R, Wolffram S, Dulak J, Rimbach G. Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in
cultured kidney tubulus cells. Food Chem Toxicol 2008; 46: 2665-71.
Breuzard G, Tertil M, Goncalves C, Cheradame H, Geguan P, Pichon C,
Midoux P. Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy
and evidence of nuclear polyplexes by FRET imaging. Nucleic Acids Res
2008; 36: e71.
Józkowicz A, Waś H, Taha H, Kotlinowski J, Mleczko K, Cisowski J, Weigel G,
Dulak J. 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through
induction of oxidative stress. Antioxid Redox Signal 2008; 10: 2035-46.
Majewska M, Zajac K, Dulak J, Szczepanik M. Heme oxygenase (HO-1) is involved in the negative regulation of contact sensitivity reaction. Pharmacol
Rep 2008; 60: 933-40.
Mashreghi MF, Klemz R, Knosalla IS, Gerstmayer B, Janssen U, Buelow R,
Józkowicz A, Dulak J, Volk HD, Kotsch K. Inhibition of dendritic cell maturation and function is independent of heme oxygenase 1 but requires the activation of STAT3. J Immunol 2008; 180: 7919-30.
Nowis D, Bugajski M, Winiarska M, Bil J, Szokalska A, Salwa P, Issat T,
Waś H, Józkowicz A, Dulak J, Stoklosa T, Golab J. Zinc protoporphyrin IX,
a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is
unable to potentiate antitumor effects of chemotherapeutics in mice. BMC
Cancer 2008; 8: 197.
52
Papiez MA, Cierniak A, Krzysciak W, Bzowska M, Taha HM, Józkowicz A,
Piskula M. The changes of antioxidant defense system caused by quercetin
administration do not lead to DNA damage and apoptosis in the spleen and
bone marrow cells of rats. Food Chem Toxicol 2008; 46: 3053-8.
Reviews
Dulak J, Deshane J, Józkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation 2008; 117: 231-41.
Dulak J, Łoboda A, Józkowicz A. Effect of heme oxygenase-1 on vascular function and disease. Curr Opin Lipidol 2008; 19: 505-12.
Łoboda A, Jaźwa A, Grochot-Przęczek A, Rutkowski AJ, Cisowski J, Agarwal
A, Józkowicz A, Dulak J. Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal
2008; 10: 1767-812.
Florczyk UM, Józkowicz A, Dulak J. Biliverdin reductase: new features of an old enzyme and its potential therapeutic significance. Pharmacol Rep 2008; 60: 38-48.
Łoboda A, Waś H, Józkowicz A, Dulak J. Janus face of Nrf2-HO-1 axis in cancer-friend in chemoprevention, foe in anticancer therapy. Lung Cancer 2008; 60: 1-3.
Research grants
MNiSW, No 347/N-INCA/2008/0
Influence of deficiency and overexpression of HO-1 on mRNA and microRNA
transcriptome in keratinocytes and
lung cacner: significance for angiogenesis and tumor growth.
Principal investigator: J. Dulak
MNiSW, No 311/N-COST/2008
Role of heme oxygenase-1 in proangiogenic activity of thymidine
phosphorylase, its significance in
anti-angiogenic anti-tumor therapy.
MNiSW, No N401 297835
from October 2008 till September 2011
Role of heme oxygenase-1 in prevention of ochratoxin A-induced
kidney damage.
Principal investigator: A. Łoboda
53
MNiSW, No N301 08032/3156
from April 2007 till April 2010
Role of heme oxygenase-1 in endothelial progenitor cells: its significance in wound healing.
MNiSW, No N401 0546 33
from September 2007 till March 2009
Role of heme oxygenase-1 in regulation of expression and activity
of metalloproteinases (MMPs) in
human cancer cell line NCI-H292
and primary murine fibroblast.
MNiSW, No N 320 3311 33
from November 2007 till May 2008
Influence of heme oxygenase-1
on growth of melanoma – role of
stroma cells.
Principal investigator: A. Józkowicz
MNiSW No 512/6.PR UE/2008/7
from January 2007 till December 2008
Role of heme oxygenase-1 in stimulation of therapeutic angiogenesis in the murine hind limb ischemia
model.
Wellcome Trust Grant, International Senior Research Fellowship in
Biomedical Sciences
from February 2005 till February 2011
Protective role of heme-oxygenase-1 in endothelial cells –
construction of helper-dependent
adenoviral vectors for a long-term
heme oxygenase expression.
EU, WKP 1/1.4.1/1/2006/54/54/590
from 2006 till 2008
Polish innovative drug in the therapy of diabetes based on activation of PPARγ – preclinical study.
54
European Vascular Genomic Network (EVGN), No. LSHM-CT 2003503254
from January 2005 till December 2008
Role of heme oxygenase-1 in stimulation of therapeutic angiogenesis in the murine hind limb
ischemia model.
55
3.11. DEPARTMENT OF PLANT PHYSIOLOGY
AND BIOCHEMISTRY
Kazimierz Strzałka (PhD, DSc, Professor)
Academic staff
Monika Bojko (PhD), Leszek Fiedor (PhD), Halina Gabryś (PhD, DSc, Professor), Małgorzata Jemioła-Rzemińska (PhD), Jerzy Kruk
(PhD, DSc), Weronika Krzeszowiec (PhD),
Grażyna Majewska (PhD), Przemysław Malec
(PhD), Beata Myśliwa-Kurdziel (PhD), Andrzej
Waloszek (PhD), Justyna Widomska (PhD),
Stanisław Więckowski (PhD, DSc, Professor
emeritus)
Supporting staff
Ewa Jękot, Halina Kołodziejska, Magdalena
Kędra (PhD)
PhD students
Andrzej Czech (MSc), Jolanta Gruszka (MSc),
Kinga Kłodawska (MSc), Justyna Łabuz
(MSc), Beatrycze Nowicka (MSc), Jolanta Pierścińska (MSc), Anna Stecka (MSc), Olga Sztatelman (MSc), Renata Szymańska (MSc)
MSc students
graduated in 2008
Biotechnology: Vasilij Gorokhov, Małgorzata
Kolasińska, Katarzyna Pezda, Anna Ramenda,
Dorian Urbański
57
Research focus
• The primary processes of photosynthesis
• The influence of various factors on the physical properties of model
membranes and natural photosynthetic membranes
• The biosynthesis, biochemistry and biophysics of photosynthetic pigments
• The formation of the photosynthetic apparatus
• Pseudocyclic electron transport in chloroplasts of higher plants
• Isolation and studies on the activity of selected chloroplast enzymes
and proteins (ferredoxin:NADP+ reductase, chlorophyllase, violaxanthin de-epoxidase and others)
• The functioning of photosynthetic electron transport in stress conditions
(heavy metals, dehydration, high and low temperature, light stress and
others)
• Plant antioxidants
• The function of cytochrome b559 in photoprotection
• The xanthophyll cycle
• Photodynamic therapy
Publications
Beranova J, Jemiola-Rzeminska M, Elhottova D, Strzalka K, Konopasek I. Metabolic control of the membrane fluidity in Bacillus subtilis during cold adaptation. Biochim Biophys Acta 2008; 1778: 445-53.
Fiedor L, Kania A, Mysliwa-Kurdziel B, Orzel L, Stochel G. Understanding chlorophylls: central magnesium ion and phytyl as structural determinants. Biochim Biophys Acta 2008; 1777: 1491-500.
Gruszka J, Pawlak A, Kruk J. Tocochromanols, plastoquinol, and other biological prenyllipids as singlet oxygen quenchers-determination of singlet oxygen
quenching rate constants and oxidation products. Free Radic Biol Med 2008;
45: 920-8.
Grzyb J, Gagos M, Gruszecki WI, Bojko M, Strzalka K. Interaction of ferredoxin:NADP+ oxidoreductase with model membranes. Biochim Biophys Acta
2008; 1778: 133-42.
Grzyb J, Malec P, Rumak I, Garstka M, Strzalka K. Two isoforms of ferredoxin:NADP(+) oxidoreductase from wheat leaves: purification and initial biochemical characterization. Photosynth Res 2008; 96: 99-112.
Kruk J, Szymanska R. Occurrence of neoxanthin and lutein epoxide cycle in parasitic Cuscuta species. Acta Biochim Pol 2008; 55: 183-90.
58
Kruk J, Szymanska R, Krupinska K. Tocopherol quinone content of green algae
and higher plants revised by a new high-sensitive fluorescence detection method using HPLC-effects of high light stress and senescence. J Plant Physiol
2008; 165: 1238-47.
Kruk J, Trebst A, Plastoquinol as a singlet oxygen scavenger in photosystem II.
BBA Bioenergetics 2008; 1777: 154-162.
Kwadrans A, Litwa J, Woloszczakiewicz S, Księżarczyk E, Klimek M, Duchnowski M, Kruk J, Plytycz B. Changes in coelomocytes of the earthworm, Dendrobaena veneta, exposed to cadmium, copper, lead or nickel-contaminated soil.
Acta Biol Cracov Ser Zool 2008; 49: 57-62.
Malec P, Waloszek A, Prasad MNV, Strzałka K. Zinc reversal of energy transfer
changes induced by cadmium in PS II reaction centers as observed by wholeleaf 77K fluorescence. Plant Stress 2008; 2: 121-126.
Mysliwa-Kurdziel B, Solymosi K, Kruk J, Boddi B, Strzalka K. Solvent effects on
fluorescence properties of protochlorophyll and its derivatives with various porphyrin side chains. Eur Biophys J 2008; 37: 1185-93.
Orzel L, Fiedor L, Wolak M, Kania A, van Eldik R, Stochel G. Interplay between
acetate ions, peripheral groups, and reactivity of the core nitrogens in transmetalation of tetrapyrroles. Chemistry 2008; 14: 9419-30.
Pshybytko NL, Kruk J, Kabashnikova LF, Strzalka K. Function of plastoquinone
in heat stress reactions of plants. Biochim Biophys Acta 2008; 1777: 1393-9.
Suwalsky M, Rivera C, Sotomayor CP, Jemiola-Rzeminska M, Strzalka K. Monomethylarsonate (MMAv) exerts stronger effects than arsenate on the structure and thermotropic properties of phospholipids bilayers. Biophys Chem
2008; 132: 1-8.
Szczygiel M, Urbanska K, Jurecka P, Stawoska I, Stochel G, Fiedor L. Central
metal determines pharmacokinetics of chlorophyll-derived xenobiotics. J Med
Chem 2008; 51: 4412-8.
Szymanska R, Kruk J. Tocopherol content and isomers' composition in selected plant species. Plant Physiol Biochem 2008; 46: 29-33.
Szymanska R, Kruk J. Gamma-tocopherol dominates in young leaves of runner
bean (Phaseolus coccineus) under a variety of growing conditions: the possible functions of gamma-tocopherol. Phytochemistry 2008; 69: 2142-8.
Research grants
MNiSzW, No 2040/B/PO1/2007/33
Molecular mechanisms of adaptation and protection against oxidative stress in plants – the role
59
of photosynthetic pigments and
prenyll lipids.
Principal investigator: K. Strzałka
MNiSW, No 302 049 32/3853
Function, mechanisms of action
and biosyntesis of plant lipid antioxidants.
Principal investigator: J. Kruk
MNiSW, No 1505/PO1/2007/32
Factors determining the expression
and the acitivity of chlorophyllase.
Principal investigator: L. Fiedor
MNiSW and DFG No 50/NDFG/2007/0
Artificial membrans as model systems for the investigation of lipid
protein interactions in the tylakoid
membrans of higher plants and
green algea Mantoniella squamota.
Principal investigator: K. Strzałka
PBZ/MNiSW/07/2006/01
from August 2007 till January 2011
Polar carotenoids specificity as
membrane compounds in chloroplasts and eye retina.
Principal investigator: J. Widomska
3.12. DEPARTMENT OF PLANT PHYSIOLOGY
AND DEVELOPMENT
Jan Białczyk (PhD, DSc)
Academic staff
Dariusz Dziga (PhD), Ewa Latkowska (PhD),
Zbigniew Lechowski (PhD, DSc, emeritus),
Marcin Wasylewski (PhD)
Supporting staff
Urszula Czaja-Prokop (Msc), Anna Homińska
(MSc), Urszula Krzysztofek (MSc)
PhD students
Beata Bober (MSc)
MSc students
graduated in 2008
Environmental protection: Urszula Banaś, Ewa
Skotniczny, Alina Ziaja
Research focus
• The isolation and identification of the secondary metabolites produced
by cyanobacteria
• Determination of the toxicity and the physicochemical properties of
compounds isolated form different selected species of cyanobacteria
• The influence of chemical and physical factors on the degradation of
MC-LR – the determination of optimal conditions and the mechanism
of the reactions
• The effect of MC-LR on the repair capacity of radiation-induced DNA
damage in human lymphocytes and human glioblastoma cell lines
61
• The allelopathic activity of selected phenols produced by aquatic plants
on cyanobacterial growth and the biosynthesis of toxins
• The role of the proteolytic system of selected probiotic bacteria in the
elimination of hepatotoxins
• The allelopathic effects of lichens, via their secondary metabolites, on
plant physiology processes
• The mechanism of the root carboxylation of dissolved inorganic carbon
(DIC) and its effect on the productivity of plants
• The mechanism of movement reactions in the world of plants (plasmodia slime moulds, the nyctinastic of leaves)
• The effect of environmental conditions on tannins synthesis in plants
Publications
Bober B, Pudas K, Lechowski Z, Bialczyk J. Degradation of microcystin-LR by
ozone in the presence of Fenton reagent. Journal of Environmental Science
and Health Part a-Toxic/Hazardous Substances & Environmental Engineering
2008; 43: 186-90.
Latkowska E, Bialczyk J, Lechowski Z, Czaja-Prokop U. Responses in tomato
roots to stress caused by exposure to (+)-usnic acid. Allelopathy Journal
2008; 21: 239-52.
Research grants
CKWS, PD 9120
from April 2005 till October 2010
Risk evaluation of cyanobacteria
blooms in water reservoirs.
Principal investigator: J. Białczyk
3.13. DEPARTMENT OF MOLECULAR GENETICS
Alicja Ziemienowicz (PhD, DSc)
Acting head
of the Department
Halina Gabryś (PhD, DSc, Professor)
Academic staff
Agnieszka Katarzyna Banaś (PhD), Weronika Krzeszowiec (PhD), Wojciech Strzałka
(PhD)
Supporting staff
Jolanta Pierścińska (MSc), Olga Sztatelman
(MSc)
Research focus
• The role of proteins coded by PCNA and PCNA-like genes
• The influence of white light on the expression of blue light photoreceptors,
phototropins (PHOT1 and PHOT2)
• The influence of different methods used for gene delivery on animal cell
viability and proliferation
Publication
Appenroth KJ, Luther A, Jetschke G, Gabrys H. Modification of chromate toxicity by sulphate in duckweeds (Lemnaceae). Aquat Toxicol 2008; 89:
167-71.
63
Research grants
MNiSW, No 2 P04B016 29
from October 2005 till September 2008
Genetic transformation of mammalian cells with Agrobacterium T-DNA,
viral vectors and plasmid DNA –
comparative studies.
Principal investigator: A. Ziemienowicz
MNiSW, N N303 1395 33
The influence of light on actomyosin system active in chloroplast’
movements.
Principal investigator: H. Gabryś
EU-funded Marie Curie ITN, 7 PR
Chloroplast Signals COSI.
from July 2008 till July 2012
Principal investigator: H. Gabryś
3.14. LABORATORY OF MOLECULAR GENETICS AND VIROLOGY
Hanna Rokita (PhD, DSc, Professor)
Academic staff
Irena Horwacik (PhD), Magdalena Kosz-Vnenchak (PhD, DSc)
Supporting staff
Katarzyna Kirsz (MSc, Eng)
PhD students
Anna Buchała (MSc), Małgorzata Gil (MSc)
MSc students
graduated in 2008
Biotechnology: Izabella Ślęzak
Research focus
• Immunotherapy of cancer using peptides mimicking the structure
of cell surface antigens
• Immunotherapy of neuroblastoma using peptides that mimick
GD2 ganglioside and induce immune response that is capable of
eliciting protection against tumor challenge in mice
• The molecular mechanisms of herpes simplex virus
• The correlation between viral latency and reactivation in patients
after transplantation
• Application of modified molecular methods in virus diagnosis
65
Publications
Slomczynska M, Duda M, Burek M, Knapczyk K, Czaplicki D, Koziorowski M.
Distribution of androgen receptor in the porcine uterus throughout pregnancy.
Reprod Domest Anim 2008; 43: 35-41.
Szostek S, Klimek M, Zawilinska B, Kosz-Vnenchak M. Physical state of human papillomavirus type 16 in cervical cell DNA. Folia Biol (Krakow) 2008;
56: 269-71.
Szostek S, Klimek M, Zawilinska B, Kosz-Vnenchak M. Genotype-specific human papillomavirus detection in cervical smears. Acta Biochim Pol 2008; 55:
687-92.
Wierzbicki A, Gil M, Ciesielski M, Fenstermaker RA, Kaneko Y, Rokita H,
Lau JT, Kozbor D. Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells. J Immunol 2008; 181: 6644-53.
Zawilinska B, Kosinska A, Lenart M, Kopec J, Piatkowska-Jakubas B, Skotnicki
A, Kosz-Vnenchak M. Detection of specific lytic and latent transcripts can
help to predict the status of Epstein-Barr virus infection in transplant recipients with high virus load. Acta Biochim Pol 2008; 55: 693-9.
Research grants
MNiSW 63/6.PR UE/2007/7
from 2007 till 2010
phase proteins.
European Commission Project,
6.FP - Marie Curie Transfer
of Knowledge, contract no 42586
phase proteins.
from 2006 till 2010
Investigator: I. Horwacik
MNiSW, PO4A 07829
Identification of early cellular response genes, regulated by transcription factor Elk-1, as a result of
kinase MAP cascade activation.
from 2005 till 2008
Coordinator: H. Rokita
Principal investigator: A. Kasza
MNiSW, N401 082 32/1930
from 2007 till 2010
66
Correlation between latency and reactivation of human cytomegalovirus
(HCMV) after allogenic bone marrow transplantation.
Principal investigator: M. Kosz-Vnenchak
MNiSW, P01 3063/2006/31
from 2006 till 2009
Analysis of molecular mimicry of
GD2 ganglioside by peptides isolated from phage-displayed peptide
library. Characterisation of anti-tumour activity of identified peptides
using murine neuroblastoma model.
Principal investigator: I. Horwacik
MNiSW, PhD grant Nr N401 1149/33
from 2007 till 2008
Analysis of a natural immune response in neuroblastoma patients.
MNiSW, N301 1586/35
from November 2008
till November 2011
Analysis of signal transmission
path responsible for cytotoxicity of
14G2a monoclonal antibody in regards to cancer cells displaying
ganglioside GD2 expression.
67
3.15. LABORATORY OF CELL BIOPHYSICS
Jerzy Dobrucki (PhD, DSc)
Academic staff
Tytus Bernaś (PhD), Krzysztof Wójcik (MD),
Mirosław Zarębski (PhD)
Supporting staff
Wiesław Nagraba
PhD students
Katarzyna Kędziora (MSc), Mateusz Kuzak
(MSc), Dominika Trembecka (MSc), Elżbieta
Wiernasz (MSc), Ewa Witkowska (MSc)
MSc students
graduated in 2008
Biotechnology: Natalia Celejewska, Patrycja
Warchocka
Biophysics: Anna Gajdek, Katarzyna Kędziora,
Dominika Trembecka, Tomasz Włodarski
Research focus
Biophysical phenomena at the cellular level:
• Genomics – the role of higher order chromatin structures in replication
and transcription, the function of heterochromatin proteins 1 (HP1), interactions between drugs and DNA in vivo
• Intercellular communication – the structure of the extracellular matrix,
the visualisation of collagenous structures in live tissues
• Confocal microscopy – photobleaching, phototoxicity, light scattering
69
Publications
Dutko-Gwóźdź J, Gwóźdź T, Orłowski M, Gręb-Markiewicz B, Duś D, Dobrucki
J, Ozyhar A. The variety of complexes formed by EcR and Usp nuclear receptors in the nuclei of living cells. Mol Cell Endocrinol 2008; 294: 45-51.
Wójcik K, Dobrucki JW. Interaction of a DNA intercalator DRAQ5, and a minor
groove binder SYTO17, with chromatin in live cells--influence on chromatin organization and histone-DNA interactions. Cytometry A 2008; 73: 555-62.
Research grants
MNiSW, N N302 025 32/2067
Fluorescent probe for investigating collagen fibers in live tissues,
using methods of confocal microscopy.
Principal investigator: J. Dobrucki
MNiSW, N N301 463834
2008-2011
Quantitative recording, analysis
and interpretation of biological microscopy data.
Principal investigator: T. Bernaś
6th EFP, No BM0703
2008-2011
Cancer and Control of Genomic
Integrity (CANGENIN) COST Action BM0703.
Principal investigator: J. Dobrucki
MNiSzW N N 301 062534
2008-2011
Characterizing subnuclear bodies,
containing heterochrmatin protein 1 (HP1).
PhD project of M. Kuzak
4.1. DSc Degrees
April 7, 2008
Jarosław Czyż
Faculty of Biochemistry, Biophysics
and Biotechnology,
Research on gap junctions in embryonic stem
cell-derived cardiogenesis and in neoplastic
cell populations
Jagiellonian University
(Doctor
of Sciences awarded at the
Reviewers: Jan Doroszewski (PhD, DSc, Prof.), Przemy-
Faculty of Biology and Earth Scien-
slaw Janik (PhD, DSc, Prof.), Jerzy Oraczewski (PhD,
ces, Jagiellonian University)
DSc, Prof.), Barbara Płytycz (PhD, DSc, Prof.)
Tadeusz Andruniów
Modelling of photoinducible processes in selected biological systems
June 24, 2008
Faculty of Chemistry Wrocław University of Technology
(Doctor
of Sciences awarded at the
Reviewers: Marta Pasenkiewicz-Gierula (PhD, DSc, Prof.),
Faculty of Biochemistry, Biophysics
Janusz Rak (PhD, DSc, Prof.), Stanisław Przestalski
and Biotechnology, Jagiellonian Uni-
(PhD, DSc, Prof.), Krzysztof Gwoździński (PhD, DSc,
versity)
Prof.)
71
4.2. PhD Degrees
Barbara Paugh
January 8, 2008
Regulation of sphingosine kinase 1 and plasminogen activator inhibitor 1 in glioblastoma cells.
Supervisors: Tomasz Kordula (PhD), Wirginia Commonwealth University, Richmond, VA, USA and Hanna Rokita
(PhD, DSc, Prof.)
Reviewers: Zdzisław Krawczyk (PhD, DSc, Prof.), Joanna
Bereta (PhD, DSc)
Magdalena Pukło
March 4, 2008
Modulation of bacteriostatic activity of cationic
antibacterial peptides by proteolytic enzymes
of Porphyromonas gingivalis.
Supervisor: Jan Potempa (PhD, DSc, Prof.)
Reviewers: Wiesław Wątorek (PhD, DSc, Prof.), Adam Dubin (PhD, DSc, Prof.)
Miłosz Gruca
March 4, 2008
Zymogenic charakter of secretory proteinases
of Staphylococcus aureus (prostafopains) and
their significance in pathogenesis of staphylococcal infections.
Supervisor: Jan Potempa (PhD, DSc, Prof.)
Reviewers: Adam Dubin (PhD, DSc, Prof.), Wiesław Wątorek (PhD, DSc, Prof.)
Piotr Liguziński
March 11, 2008
Theoretical investigations on control and regulation of oxidative phosphorylation and glycolysis in skeletal muscles.
Supervisor: Bernard Korzeniewski (PhD, DSc)
Reviewers: Jerzy Duszyński (PhD, DSc, Prof.), Jerzy Żołądź (PhD, DSc, Prof.)
73
Małgorzata Kalemba-Drożdż
March 14, 2008
Effect of metabolizm of 17β-estradiol on the level of lymphocyte DNA damage of pregnant
women
Supervisor: Maria Kapiszewska (PhD, DSc, Prof.)
Reviewers: Małgorzata Sąsiadek (PhD, DSc, Prof.), Jolanta Jura (PhD, DSc)
Renata Mężyk-Kopeć
April 1, 2008
Identification and characteristics of expression
of TNF secretases other than TACE
Supervisor: Joanna Bereta (PhD, DSc)
Reviewers: Jacek Bigda (PhD, DSc, Prof.), Hanna Rokita
(PhD, DSc, Prof.)
Paulina Kulig
April 11, 2008
Proteases role in activation of chemotactic factor – chemerin
Supervisor: Joanna Cichy (PhD, DSc)
Reviewers: Jakub Gołąb (PhD, DSc, Prof.), Andrzej Kozik
(PhD, DSc, Prof.)
Mirosław Zarębski
April 25, 2008
Application of photodynamic local damage of
cellular content to studying the repair mechanisms of cellular membranes and chromatin
Supervisor: Jerzy Dobrucki (PhD, D.Sc.)
Reviewers: Grzegorz Bartosz (PhD, DSc, Prof.), Maria Kapiszewska (PhD, DSc, Prof.)
Anna Wilk
May 9, 2008
Horizontal electrophoresis of cells under isopycnic conditions
Supervisor: Włodzimierz Korohoda (PhD, D.Sc., Prof.)
Reviewer: Grzegorz Bartosz (PhD, DSc, Prof.), Andrzej
Klein (PhD, DSc, Prof.)
Agnieszka Waligórska
May 27, 2008
74
Experimental modification of cellular motility
activity of Dictyostelium discoideum and its in-
fluence on chemoattractant recognition
Supervisor: Włodzimierz Korohoda (PhD, DSc, Prof.)
Reviewer: Wanda Kłopocka (PhD, DSc), Andrzej Klein
(PhD, DSc, Prof.)
Natalia Małachowa
May 30, 2008
Characteristics of surface virulent factor of Staphylococcus aureus, increasing bacterial survival under oxidative stress
Supervisor: Jacek Międzybrodzki (PhD, DSc)
Reviewers: Anna Przondo-Mordarska (PhD, DSc, Prof.),
Adam Dubin (PhD, DSc, Prof.)
Agnieszka Broniec
June 13, 2008
Anti-oxidative properties of plasmalogens in
chosen model systems
Supervisor: Tadeusz Sarna (PhD, DSc, Prof.)
Reviewers: Grzegorz Bartosz (PhD, DSc, Prof.), Witold Korytowski (PhD, DSc)
Ali Saeed
July 11, 2008
Surface properties and in vitro antagonistic activity of Lactobacillus strains isolated from healthy individuals against oral pathogens
Supervisor: Piotr Heczko (PhD, DSc, Prof.) Collegium Medicum UJ
Reviewers: Hanna Szajerska (PhD, DSc, Prof.), Juliusz
Pryjma (PhD, DSc, Prof.)
Gracjana Krzysiek-Mączka
October 24, 2008
Influence of ground anisotropy on cells division
orientation
Supervisor: Włodzimierz Korohoda (PhD, DSc, Prof.)
Reviewers: Ewa Przyboś (PhD, DSc, Prof.), Zbigniew Madeja (PhD, DSc)
Agnieszka Jaźwa
November 4, 2008
Bicistronic plasmid and AAV vectors delivering
VEGF and FGF-4 genes for the stimulation of
75
neovascularization processes
Supervisor: Józef Dulak (PhD, DSc, Prof.)
Reviewers: Marcin Gruchała (PhD, DSc), Hanna Rokita
(PhD, DSc, Prof.)
Marcin Sarewicz
November 14, 2008
Research on interaction of c-cytochrome with
complex bc1 using electron paramagnetic resonance method.
Supervisor: Wojciech Froncisz (PhD, DSc, Prof.)
Reviewers: Grzegorz Bartosz (PhD, DSc, Prof.), Ryszard
Gurbiel (PhD, DSc)
Katarzyna Bulek
December 16, 2008
The essential role of SIGIRR in regulation of
the TH2 immune response
Supervisors: Magdalena Kosz-Vnenchak (PhD), Xiaoxia Li
(PhD), Lerner Research Institute, The Cleveland Clinic Foundation, USA
Reviewers: Juliusz Pryjma (PhD, DSc, Prof.), Barbara Lipińska (PhD, DSc, Prof.)
5. PUBLICATIONS 2008
(ACCORDING TO ISI WEB OF SCIENCE)
1. Almolki A, Guenegou A, Gołda S, Boyer L, Benallaoua M, Amara N, Bachoual R, Martin C,
Rannou F, Lanone S, Dulak J, Burgel PR, El-Benna J, Leynaert B, Aubier M, Boczkowski J.
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans. Am J Pathol 2008; 173: 981-92.
2. Appenroth KJ, Luther A, Jetschke G, Gabryś H. Modification of chromate toxicity by sulphate in
duckweeds (Lemnaceae). Aquat Toxicol 2008; 89: 167-71.
3. Balwierz A, Czech U, Polus A, Filipkowski RK, Mioduszewska B, Prószynski T, Kołodziejczyk P,
Skrzeczyńska-Moncznik J, Dudek W, Kaczmarek L, Kulig J, Pryjma J, Dembińska-Kieć A.
Human adipose tissue stromal vascular fraction cells differentiate depending on distinct types
of media. Cell Prolif 2008; 41: 441-59.
4. Barbasz A, Guevara-Lora I, Rąpała-Kozik M, Kozik A. Kininogen binding to the surfaces of
macrophages. Int Immunopharmacol 2008; 8: 211-6.
5. Beaufort N, Wojciechowski P, Sommerhoff CP, Szmyd G, Dubin G, Eick S, Kellermann J,
Schmitt M, Potempa J, Magdolen V. The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin. Biochem J 2008; 410: 157-65.
6. Beranova J, Jemioła-Rzemińska M, Elhottova D, Strzałka K, Konopasek I. Metabolic control
of the membrane fluidity in Bacillus subtilis during cold adaptation. Biochim Biophys Acta 2008;
1778: 445-53.
7. Bober B, Pudas K, Lechowski Z, Białczyk J. Degradation of microcystin-LR by ozone in
the presence of Fenton reagent. Journal of Environmental Science and Health Part a-Toxic/Hazardous Substances & Environmental Engineering 2008; 43: 186-90.
8. Boesch-Saadatmandi C, Łoboda A, Józkowicz A, Huebbe P, Blank R, Wolffram S, Dulak J,
Rimbach G. Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells. Food Chem Toxicol 2008;
46: 2665-71.
9. Bonarek P, Kędracka-Krok S, Kępys B, Wasylewski Z. Quantitative analysis of the ternary
complex of RNA polymerase, cyclic AMP receptor protein and DNA by fluorescence anisotropy
measurements. Acta Biochim Pol 2008; 55: 537-47.
10. Borek A, Sarewicz M, Osyczka A. Movement of the iron-sulfur head domain of cytochrome
bc(1) transiently opens the catalytic Q(o) site for reaction with oxygen. Biochemistry 2008; 47:
12365-70.
11. Breuzard G, Tertil M, Goncalves C, Cheradame H, Geguan P, Pichon C, Midoux P. Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging. Nucleic Acids
Res 2008; 36: e71.
12. Bunker A, Mannisto P, St Pierre JF, Róg T, Pomorski P, Stimson L, Karttunen M. Molecular dynamics simulations of the enzyme catechol-O-methyltransferase: methodological issues. SAR
QSAR Environ Res 2008; 19: 179-89.
13. Calander AM, Dubin G, Potempa J, Tarkowski A. Staphylococcus aureus infection triggers production of neutralizing, V8 protease-specific antibodies. FEMS Immunol Med Microbiol 2008;
52: 267-72.
14. Czernik M Sroka J, Madeja Z, Czyż J. Apigenin inhibits growth and motility but increases gap
77
junctional coupling intensity in rat prostate carcinoma (MAT-LyLu) cell populations. Cell Mol Biol
Lett 2008; 13: 327-38.
15. Czyż J. The stage-specific function of gap junctions during tumourigenesis. Cell Mol Biol Lett
2008; 13: 92-102.
16. Daniel-Wójcik A, Misztal K, Bechyne I, Sroka J, Miękus K, Madeja Z, Czyż J. Cell motility
affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations. Int J Oncol 2008; 33: 309-15.
17. de Vries M, Pyrć K, Berkhout R, Vermeulen-Oost W, Dijkman R, Jebbink MF, Bruisten S, Berkhout B, van der Hoek L. Human parechovirus type 1, 3, 4, 5, and 6 detection in picornavirus
cultures. J Clin Microbiol 2008; 46: 759-62.
18. Dijkman R, Jebbink MF, El Idrissi NB, Pyrć K, Muller MA, Kuijpers TW, Zaaijer HL, van der Hoek L. Human coronavirus NL63 and 229E seroconversion in children. J Clin Microbiol 2008; 46:
2368-73.
19. Dubin G, Stec-Niemczyk J, Kisielewska M, Pustelny K, Popowicz GM, Biśta M, Kantyka T,
Boulware KT, Stennicke HR, Czarna A, Phopaisarn M, Daugherty PS, Thogersen IB, Enghild JJ, Thornberry N, Dubin A, Potempa J. Enzymatic activity of the Staphylococcus aureus
SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln. J Mol
Biol 2008; 379: 343-56.
20. Dulak J, Deshane J, Józkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation 2008; 117: 231-41.
21. Dulak J, Łoboda A, Józkowicz A. Effect of heme oxygenase-1 on vascular function and disease. Curr Opin Lipidol 2008; 19: 505-12.
22. Dutko-Gwóźdź J, Gwóźdź T, Orłowski M, Gręb-Markiewicz B, Duś D, Dobrucki J, Ożyhar A.
The variety of complexes formed by EcR and Usp nuclear receptors in the nuclei of living cells.
Mol Cell Endocrinol 2008; 294: 45-51.
23. Dzbęk J, Korzeniewski B. Control over the contribution of the mitochondrial membrane potential (DeltaPsi) and proton gradient (DeltapH) to the protonmotive force (Deltap). In silico studies. J Biol Chem 2008; 283: 33232-9.
24. Dziedzicka-Wasylewska M, Faron-Górecka A, Górecki A, Kuśmider M. Mechanism of action
of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization--a working hypothesis. Pharmacol Rep 2008; 60: 581-7.
25. Elas M, Bell R, Hleihel D, Barth ED, Mcfaul C, Haney CR, Bielańska J, Pustelny K, Ahn KH,
Pelizzari CA, Kocherginsky M, Halpern HJ. Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSA fibrosarcomas. International Journal of Radiation Oncology Biology Physics 2008; 71: 542-9.
26. Elas M, Bielańska J, Pustelny K, Płonka PM, Drelicharz Ł, Skórka T, Tyrankiewicz U, Woźniak M, Heinze-Paluchowska S, Walski M, Wojnar L, Fortin D, Ventura-Clapier R, Chłopicki S.
Detection of mitochondrial dysfunction by EPR technique in mouse model of dilated cardiomyopathy. Free Radic Biol Med 2008; 45: 321-8.
27. Falck E, Róg T, Karttunen M, Vattulainen I. Lateral diffusion in lipid membranes through collective flows. J Am Chem Soc 2008; 130: 44-5.
28. Faron-Górecka A, Górecki A, Kuśmider M, Wasylewski Z, Dziedzicka-Wasylewska M.
The role of D1-D2 receptor hetero-dimerization in the mechanism of action of clozapine. Eur
Neuropsychopharmacol 2008; 18: 682-91.
29. Fiedor L, Kania A, Myśliwa-Kurdziel B, Orzeł Ł, Stochel G. Understanding chlorophylls: central magnesium ion and phytyl as structural determinants. Biochim Biophys Acta 2008; 1777:
1491-500.
30. Florczyk UM, Józkowicz A, Dulak J. Biliverdin reductase: new features of an old enzyme and
its potential therapeutic significance. Pharmacol Rep 2008; 60: 38-48.
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31. Frączek J, Kim TW, Xiao H, Yao J, Wen Q, Li Y, Casanova JL, Pryjma J, Li X. The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation. J Biol Chem 2008; 283: 31697-705.
32. Froncisz W, Camenisch TG, Ratke JJ, Anderson JR, Subczyński WK, Strangeway RA, Sidabras JW, Hyde JS. Saturation recovery EPR and ELDOR at W-band for spin labels. J Magn Reson 2008; 193: 297-304.
33. Galanty A, Michalik M, Sędek Ł, Podolak I. The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells. Cell Mol Biol Lett
2008; 13: 585-98.
34. Golda A, Pyrć K. Recent antiviral strategies against human coronavirus-related respiratory illnesses. Current Opinion in Pulmonary Medicine 2008; 14: 248-53.
35. Grabacka M, Placha W, Urbańska K, Laidler P, Płonka PM, Reiss K. PPAR gamma regulates
MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91. Pigment Cell Melanoma Res 2008; 21: 388-96.
36. Gruszka J, Pawlak A, Kruk J. Tocochromanols, plastoquinol, and other biological prenyllipids
as singlet oxygen quenchers-determination of singlet oxygen quenching rate constants and oxidation products. Free Radic Biol Med 2008; 45: 920-8.
37. Grymek K, Gąska M, Łukasiewicz S, Górecki A, Dziedzicka-Wasylewska M. [Fluorescence
studies of G-protein coupled receptors oligomerization]. Postepy Biochem 2008; 54: 431-7.
38. Grzyb J, Gagos M, Gruszecki WI, Bojko M, Strzałka K. Interaction of ferredoxin:NADP+ oxidoreductase with model membranes. Biochim Biophys Acta 2008; 1778: 133-42.
39. Grzyb J, Malec P, Rumak I, Garstka M, Strzałka K. Two isoforms of ferredoxin:NADP(+) oxidoreductase from wheat leaves: purification and initial biochemical characterization. Photosynth
Res 2008; 96: 99-112.
40. Guzik K, Potempa J. Friendly fire against neutrophils: proteolytic enzymes confuse the recognition of apoptotic cells by macrophages. Biochimie 2008; 90: 405-15.
41. Hannes B, Vieillard J, Chakra EB, Mazurczyk R, Mansfield CD, Potempa J, Krawczyk S, Cabrera M. The etching of glass patterned by microcontact printing with application to microfluidics and electrophoresis. Sensors and Actuators B-Chemical 2008; 129: 255-62.
42. Holko P, Ligęza J, Kisielewska J, Kordowiak AM, Klein A. The effect of vanadyl sulphate
(VOSO4) on autocrine growth of human epithelial cancer cell lines. Pol J Pathol 2008; 59: 3-8.
43. Homa J, Bzowska M, Klimek M, Płytycz B. Flow cytometric quantification of proliferating coelomocytes non-invasively retrieved from the earthworm, Dendrobaena veneta. Dev Comp Immunol 2008; 32: 9-14.
44. Hu DN, Simon JD, Sarna T. Role of ocular melanin in ophthalmic physiology and pathology.
Photochemistry and Photobiology 2008; 84: 639-44.
45. Jańczyk A, Wolnicka-Głubisz A, Urbańska K, Kisch H, Stochel G, Macyk W. Photodynamic
activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light. Free Radic
Biol Med 2008; 44: 1120-30.
46. Jańczyk A, Wolnicka-Głubisz A, Urbańska K, Stochel G, Macyk W. Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages. J Photochem Photobiol B 2008; 92: 54-8.
47. Janus AM, Faryna M, Haberko K, Rakowska A, Panz T. Chemical and microstructural characterization of natural hydroxyapatite derived from pig bones. Microchimica Acta 2008; 161: 349-53.
48. Josefsson E, Kubica M, Mydel P, Potempa J, Tarkowski A. In vivo sortase A and clumping factor A mRNA expression during Staphylococcus aureus infection. Microbial Pathogenesis 2008;
44: 103-10.
49. Józkowicz A, Waś H, Taha H, Kotlinowski J, Mleczko K, Cisowski J, Weigel G, Dulak J.
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15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative
stress. Antioxid Redox Signal 2008; 10: 2035-46.
50. Jura J, Węgrzyn P, Korostynski M, Guzik K, Oczko-Wojciechowska M, Jarząb M, Kowalska M,
Piechota M, Przewłocki R, Koj A. Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays. Biochim Biophys Acta 2008;
1779: 383-9.
51. Jurek A, Turyna B, Kubit P, Klein A. The ability of HDL to inhibit VCAM-1 expression and oxidized LDL uptake is impaired in renal patients. Clin Biochem 2008; 41: 1015-8.
52. Kędzierska A, Kapińska-Mrowiecka M, Czubak-Macugowska M, Wójcik K, Kędzierska J. Susceptibility testing and resistance phenotype detection in Staphylococcus aureus strains isolated from patients with atopic dermatitis, with apparent and recurrent skin colonization. Br J
Dermatol 2008; 159: 1290-9.
53. Kisielewska J, Ligęza J, Klein A. The effect of tyrosine kinase inhibitors, tyrphostins: AG1024
and SU1498, on autocrine growth of prostate cancer cells (DU145). Folia Histochem Cytobiol
2008; 46: 185-91.
54. Klein A, Holko P, Ligęza J, Kordowiak AM. Sodium orthovanadate affects growth of some human epithelial cancer cells (A549, HTB44, DU145). Folia Biol (Kraków) 2008; 56: 115-21.
55. Korohoda W, Wilk A. Cell electrophoresis - a method for cell separation and research into cell
surface properties. Cell Mol Biol Lett 2008; 13: 312-26.
56. Korzeniewski B, Deschodt-Arsac V, Calmettes G, Franconi JM, Diolez P. Physiological heart
activation by adrenaline involves parallel activation of ATP usage and supply. Biochem J 2008;
413: 343-7.
57. Kowalska E, Kozik A. The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts. Cellular & Molecular Biology Letters 2008; 13: 271-82.
58. Kozieł J, Maciąg-Gudowska A, Potempa J. Staphylococcus aureus as an intracellular pathogen of immunological cells. Postepy Mikrobiologii 2008; 47: 393-9.
59. Kruk J, Szymańska R. Occurrence of neoxanthin and lutein epoxide cycle in parasitic Cuscuta
species. Acta Biochim Pol 2008; 55: 183-90.
60. Kruk J, Szymańska R, Krupińska K. Tocopherol quinone content of green algae and higher
plants revised by a new high-sensitive fluorescence detection method using HPLC–effects of
high light stress and senescence. J Plant Physiol 2008; 165: 1238-47.
61. Kruk J, Trebst A. Plastoquinol as a singlet oxygen scavenger in photosystem II. Biochim Biophys Acta 2008; 1777: 154-62.
62. Krzysiek-Mączka G, Korohoda W. Surface anisotropy orients cell divisions in contact guided
cells. Folia Biologica-Krakow 2008; 56: 13-9.
63. Krzywda A, Petelenz E, Michalczyk D, Płonka PM. Sclerotia of the acellular (true) slime mould Fuligo septica as a model to study melanization and anabiosis. Cell Mol Biol Lett 2008; 13:
130-43.
64. Kubica M, Guzik K, Kozieł J, Zarębski M, Richter W, Gajkowska B, Golda A, Maciąg-Gudowska A, Brix K, Shaw L, Foster T, Potempa J. A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived
macrophages. PLoS One 2008; 3: e1409.
65. Latkowska E, Białczyk J, Lechowski Z, Czaja-Prokop U. Responses in tomato roots to stress
caused by exposure to (+)-usnic acid. Allelopathy Journal 2008; 21: 239-52.
66. Lee DW, Ozturk Y, Osyczka A, Cooley JW, Daldal F. Cytochrome bc1-cy fusion complexes reveal the distance constraints for functional electron transfer between photosynthesis components. J Biol Chem 2008; 283: 13973-82.
67. Lenartowicz M, Brzęk B, Polanski Z, Sierpniowska A, Galas J, Bilinska B. Changes in germ
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cells population and in vitro oocyte maturation in female mice with imperforated vagina. J Exp
Zool Part A Ecol Genet Physiol 2008; 309: 269-77.
68. Łoboda A, Jaźwa A, Grochot-Przęczek A, Rutkowski AJ, Cisowski J, Agarwal A, Józkowicz A, Dulak J. Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2008; 10: 1767-812.
69. Łoboda A, Waś H, Józkowicz A, Dulak J. Janus face of Nrf2-HO-1 axis in cancer--friend in
chemoprevention, foe in anticancer therapy. Lung Cancer 2008; 60: 1-3.
70. Lushchak V, Abrat O, Międzobrodzki J, Semchyshyn H. Pdr12p-dependent and -independent
fluorescein extrusion from baker's yeast cells. Acta Biochim Pol 2008; 55: 595-601.
71. Majewska M, Zając K, Dulak J, Szczepanik M. Heme oxygenase (HO-1) is involved in the negative regulation of contact sensitivity reaction. Pharmacol Rep 2008; 60: 933-40.
72. Mak P. Hemocidins in a functional and structural context of human antimicrobial peptides. Frontiers in Bioscience 2008; 13: 6859-71.
73. Mak P, Maszewska A, Różalska M. The amino acid sequences and activities of synergistic hemolysins from Staphylococcus cohnii. FEMS Microbiol Lett 2008; 287: 230-5.
74. Mallorqui-Fernandez N, Manandhar SP, Mallorqui-Fernandez G, Uson I, Wawrzonek K, Kantyka T, Sola M, Thogersen IB, Enghild JJ, Potempa J, Gomis-Ruth FX. A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. J Biol
Chem 2008; 283: 2871-82.
75. Martinez-Seara H, Róg T, Karttunen M, Reigada R, Vattulainen I. Influence of cis double-bond
parametrization on lipid membrane properties: How seemingly insignificant details in force-field
change even qualitative trends. Journal of Chemical Physics 2008; 129: 105103.
76. Martinez-Seara H, Róg T, Pasenkiewicz-Gierula M, Vattulainen I, Karttunen M, Reigada R. Interplay of unsaturated phospholipids and cholesterol in membranes: Effect of the double-bond
position. Biophysical Journal 2008; 95: 3295-305.
77. Mashreghi MF, Klemz R, Knosalla IS, Gerstmayer B, Janssen U, Buelow R, Józkowicz A, Dulak J, Volk HD, Kotsch K. Inhibition of dendritic cell maturation and function is independent of
heme oxygenase 1 but requires the activation of STAT3. J Immunol 2008; 180: 7919-30.
78. Międzobrodzki J, Malachowa N, Markiewski T, Białecka A, Kasprowicz A. Differentiation of
Staphylococcus aureus isolates based on phenotypical characters. Postepy Higieny I Medycyny Doswiadczalnej 2008; 62: 322-7.
79. Międzobrodzki J, Panz T, Płonka PM, Zając K, Dracz J, Pytel K, Mateuszuk L, Chłopicki S.
Platelets augment respiratory burst in neutrophils activated by selected species of gram-positive or gram-negative bacteria. Folia Histochem Cytobiol 2008; 46: 383-8.
80. Myśliwa-Kurdziel B, Solymosi K, Kruk J, Boddi B, Strzałka K. Solvent effects on fluorescence properties of protochlorophyll and its derivatives with various porphyrin side chains. Eur Biophys J 2008; 37: 1185-93.
81. Nilsson M, Wasylik S, Morgelin M, Olin AI, Meijers JC, Derksen RH, de Groot PG, Herwald H.
The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by
protein H and M1 protein from Streptococcus pyogenes. Mol Microbiol 2008; 67: 482-92.
82. Noack B, Gorgens H, Schacher B, Pukło M, Eickholz P, Hoffmann T, Schackert HK. Functional
Cathepsin C mutations cause different Papillon-Lefevre syndrome phenotypes. J Clin Periodontol 2008; 35: 311-6.
83. Nowis D, Bugajski M, Winiarska M, Bil J, Szokalska A, Salwa P, Issat T, Waś H, Józkowicz A,
Dulak J, Stokłosa T, Gołąb J. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics
in mice. BMC Cancer 2008; 8: 197.
84. Olczak T, Sroka A, Potempa J, Olczak M. Porphyromonas gingivalis HmuY and HmuR: further
characterization of a novel mechanism of heme utilization. Arch Microbiol 2008; 189: 197-210.
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85. Opiela J, Kątska-Książkiewicz L, Lipiński D, Słomski R, Bzowska M, Ryńska B. Interactions
among activity of glucose-6-phosphate dehydrogenase in immature oocytes, expression of
apoptosis-related genes Bcl-2 and Bax, and developmental competence following IVP in cattle.
Theriogenology 2008; 69: 546-55.
86. Orzeł Ł, Fiedor L, Wolak M, Kania A, van Eldik R, Stochel G. Interplay between acetate ions,
peripheral groups, and reactivity of the core nitrogens in transmetalation of tetrapyrroles. Chemistry 2008; 14: 9419-30.
87. Ozturk Y, Lee DW, Mandaci S, Osyczka A, Prince RC, Daldal F. Soluble variants of Rhodobacter capsulatus membrane-anchored cytochrome cy are efficient photosynthetic electron carriers. J Biol Chem 2008; 283: 13964-72.
88. Panz T, Wojcik R, Krukar-Baster K. Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. Acta Biochim Pol 2008; 55: 821-3.
89. Papież MA, Cierniak A, Krzyściak W, Bzowska M, Taha HM, Józkowicz A, Piskuła M. The
changes of antioxidant defense system caused by quercetin administration do not lead to DNA
damage and apoptosis in the spleen and bone marrow cells of rats. Food Chem Toxicol 2008;
46: 3053-8.
90. Paugh BS, Paugh SW, Bryan L, Kapitonov D, Wilczyńska KM, Gopalan SM, Rokita H, Milstien S,
Spiegel S, Kordula T. EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells. Faseb J 2008; 22: 455-65.
91. Płonka PM, Michalczyk D, Popik M, Handjiski B, Paus R. Electron paramagnetic resonance
(EPR) spectroscopy for investigating murine telogen skin after spontaneous or depilation-induced hair growth. J Dermatol Sci 2008; 49: 227-40.
92. Potempa M, Potempa J, Okrój M, Popadiak K, Eick S, Nguyen KA, Riesbeck K, Blom AM.
Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis. J Immunol 2008; 181: 5537-44.
93. Poyry S, Róg T, Karttunen M, Vattulainen I. Significance of cholesterol methyl groups. J Phys
Chem B 2008; 112: 2922-9.
94. Pshybytko NL, Kruk J, Kabashnikova LF, Strzałka K. Function of plastoquinone in heat stress
reactions of plants. Biochim Biophys Acta 2008; 1777: 1393-9.
95. Pukło M, Guentsch A, Hiemstra PS, Eick S, Potempa J. Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral Microbiol Immunol 2008; 23:
328-35.
96. Pyrć K. Human coronavirus NL63 – molecular characteristics and clinical image. Postepy Mikrobiologii 2008; 47: 257-62.
97. Rąpała-Kozik M, Karkowska J, Jacher A, Golda A, Barbasz A, Guevara-Lora I, Kozik A. Kininogen adsorption to the cell surface of Candida spp. Int Immunopharmacol 2008; 8: 237-41.
98. Rąpała-Kozik M, Kowalska E, Ostrowska K. Modulation of thiamine metabolism in Zea mays
seedlings under conditions of abiotic stress. Journal of Experimental Botany 2008; 59: 4133-43.
99. Róg T, Murzyn K, Karttunen M, Pasenkiewicz-Gierula M. Nonpolar interactions between
trans-membrane helical EGF peptide and phosphatidylcholines, sphingomyelins and cholesterol. Molecular dynamics simulation studies. J Pept Sci 2008; 14: 374-82.
100. Róg T, Stimson LM, Pasenkiewicz-Gierula M, Vattulainen I, Karttunen M. Replacing the cholesterol hydroxyl group with the ketone group facilitates sterol flip-flop and promotes membrane fluidity. J Phys Chem B 2008; 112: 1946-52.
101. Róg T, Vattulainen I, Jansen M, Ikonen E, Karttunen M. Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers. J Chem Phys 2008; 129: 154508.
82
102. Różanowski B, Burke J, Sarna T, Różanowska M. The pro-oxidant effects of interactions of
ascorbate with photoexcited melanin fade away with aging of the retina. Photochemistry and
Photobiology 2008; 84: 658-70.
103. Różanowski B, Burke JM, Boulton ME, Sarna T, Różanowska M. Human RPE melanosomes
protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation. Invest Ophthalmol Vis Sci 2008; 49: 2838-47.
104. Różanowski B, Cuenco J, Davies S, Shamsi FA, Żądło A, Dayhaw-Barker P, Różanowska M,
Sarna T, Boulton ME. The phototoxicity of aged human retinal melanosomes. Photochemistry
and Photobiology 2008; 84: 650-7.
105. Rydengard V, Shannon O, Lundqvist K, Kacprzyk Ł, Chałupka A, Olsson AK, Morgelin M,
Jahnen-Dechent W, Malmsten M, Schmidtchen A. Histidine-rich glycoprotein protects from systemic Candida infection. PLoS Pathog 2008; 4: e1000116.
106. Sabat AJ, Władyka B, Kosowska-Shick K, Grundmann H, van Dijl JM, Kowal J, Appelbaum PC,
Dubin A, Hryniewicz W. Polymorphism, genetic exchange and intragenic recombination of the
aureolysin gene among Staphylococcus aureus strains. BMC Microbiol 2008; 8: 129.
107. Sarewicz M, Borek A, Daldal F, Froncisz W, Osyczka A. Demonstration of short-lived complexes of cytochrome c with cytochrome bc1 by EPR spectroscopy: implications for the mechanism of interprotein electron transfer. J Biol Chem 2008; 283: 24826-36.
108. Sarewicz M, Szytuła S, Dutka M, Osyczka A, Froncisz W. Estimation of binding parameters
for the protein-protein interaction using a site-directed spin labeling and EPR spectroscopy.
Eur Biophys J 2008; 37: 483-93.
109. Shaw LN, Lindholm C, Prajsnar TK, Miller HK, Brown MC, Golonka E, Stewart GC, Tarkowski A,
Potempa J. Identification and characterization of sigma, a novel component of the Staphylococcus aureus stress and virulence responses. PLoS One 2008; 3: e3844.
110. Siddiqui K, Del Valle L, Morellet N, Cui J, Ghafouri M, Mukerjee R, Urbańska K, Fan S, Pattillo CB,
Deshmane SL, Kiani MF, Ansari R, Khalili K, Roques BP, Reiss K, Bouaziz S, Amini S, Srinivasan A, Sawaya BE. Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the
anticancer agent, cisplatin. Oncogene 2008; 27: 32-43.
111. Skrzeczyńska-Moncznik J, Bzowska M, Loseke S, Grage-Griebenow E, Zembala M, Pryjma J.
Peripheral blood CD14high CD16+ monocytes are main producers of IL-10. Scand J Immunol
2008; 67: 152-9.
112. Słomczyńska M, Duda M, Burek M, Knapczyk K, Czaplicki D, Koziorowski M. Distribution of
androgen receptor in the porcine uterus throughout pregnancy. Reprod Domest Anim 2008;
43: 35-41.
113. Smalley JW, Birss AJ, Szmigielski B, Potempa J. Mechanism of methaemoglobin breakdown
by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis. Biol
Chem 2008; 389: 1235-8.
114. Sroka J, Czyż J, Wojewoda M, Madeja Z. The inhibitory effect of diphenyltin on gap junctional intercellular communication in HEK-293 cells is reduced by thioredoxin reductase 1. Toxicol
Lett 2008; 183: 45-51.
115. Sroka J, Włosiak P, Wilk A, Antonik J, Czyż J, Madeja Z. The effect of tributyltin on human
eosinophylic leukemia EoL-1 cells. Cell Mol Biol Lett 2008; 13: 67-73.
116. Surdacki A, Marewicz E, Wieteska E, Szastak G, Rakowski T, Wieczorek-Surdacka E, Dudek D,
Pryjma J, Dubiel JS. Association between endothelial progenitor cell depletion in blood and
mild-to-moderate renal insufficiency in stable angina. Nephrol Dial Transplant 2008; 23: 2265-73.
117. Suwalsky M, Rivera C, Sotomayor CP, Jemioła-Rzemińska M, Strzałka K. Monomethylarsonate (MMAv) exerts stronger effects than arsenate on the structure and thermotropic properties of phospholipids bilayers. Biophys Chem 2008; 132: 1-8.
83
118. Szczepanek K, Kieda C, Cichy J. Differential binding of hyaluronan on the surface of tissuespecific endothelial cell lines. Acta Biochim Pol 2008; 55: 35-42.
119. Szczygieł M, Urbańska K, Jurecka P, Stawoska I, Stochel G, Fiedor L. Central metal determines pharmacokinetics of chlorophyll-derived xenobiotics. J Med Chem 2008; 51: 4412-8.
120. Szostek S, Klimek M, Zawilińska B, Kosz-Vnenchak M. Physical state of human papillomavirus type 16 in cervical cell DNA. Folia Biol (Kraków) 2008; 56: 269-71.
121. Szostek S, Klimek M, Zawilinska B, Kosz-Vnenchak M. Genotype-specific human papillomavirus detection in cervical smears. Acta Biochim Pol 2008; 55: 687-92.
122. Szymańska R, Kruk J. Tocopherol content and isomers' composition in selected plant species. Plant Physiol Biochem 2008; 46: 29-33.
123. Szymańska R, Kruk J. Gamma-tocopherol dominates in young leaves of runner bean (Phaseolus coccineus) under a variety of growing conditions: the possible functions of gamma-tocopherol. Phytochemistry 2008; 69: 2142-8.
124. Uehara A, Imamura T, Potempa J, Travis J, Takada H. Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells. Cell
Microbiol 2008; 10: 1181-9.
125. Uehara A, Naito M, Imamura T, Potempa J, Travis J, Nakayama K, Takada H. Dual regulation
of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from
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126. Urbańska K, Pannizzo P, Grabacka M, Croul S, Del Valle L, Khalili K, Reiss K. Activation of
PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines. Int J Cancer 2008; 123: 1015-24.
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129. Wielgus AR, Sarna T. Ascorbate enhances photogeneration of hydrogen peroxide mediated
by the iris melanin. Photochemistry and Photobiology 2008; 84: 683-91.
130. Wierzbicki A, Gil M, Ciesielski M, Fenstermaker RA, Kaneko Y, Rokita H, Lau JT, Kozbor D.
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366-74.
132. Wiśniewska A, Subczyński WK. The liquid-ordered phase in sphingomyelincholesterol membranes as detected by the discrimination by oxygen transport (DOT) method. Cell Mol Biol Lett
2008; 13: 430-51.
133. Władyka B, Bista M, Sabat AJ, Bonar E, Grzeszczuk S, Hryniewicz W, Dubin A. A novel
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84
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137. Ye T, Pawlak A, Sarna T, Simon JD. Different molecular constituents in pheomelanin are responsible for emission, transient absorption and oxygen photoconsumption. Photochem Photobiol 2008; 84: 437-43.
138. Zawilińska B, Kosińska A, Lenart M, Kopeć J, Piątkowska-Jakubas B, Skotnicki A, Kosz-Vnenchak M. Detection of specific lytic and latent transcripts can help to predict the status of Epstein-Barr virus infection in transplant recipients with high virus load. Acta Biochim Pol 2008; 55:
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85
6. PATENTS
Inventors: Darzynkiewicz Zbigniew [US]; Lee Brian W. [US];
Johnson Gary L. [US];
Dobrucki Jerzy W. [PL]
Applicant: Uniwersytet Jagielloński
Application number: (21) 384305
Application date: 22.01.2008
Title: Fluorescent probe for staining collagen
fibres in vivo
Inventors: Dubin Grzegorz
[PL]; Potempa Jan [PL]
Applicants: Uniwersytet Jagielloński [PL];
Biocentrum Sp. z o. o. [PL]; Dubin Grzegorz
[PL]; Potempa Jan [PL]
International application number:
PCT/PL2008/000042
International filing date: 11.06.2008
Publication number: WO/2008/153429
Publication date: 18.12.2008
Title: A protease from Staphylococcus aureus, particularly Sp1a or Sp1B, peptides
it recognises and their use
87
7. CONFERENCES ORGANIZED
BY THE FBB&B
35th Winter School of the Fa- The 35th Winter School “Structure vs. function
culty of Biochemistry, Bio- of proteins and nucleic acids”, organised by Faphysics and Biotechnology
culty of Biochemistry, Biophysics and Biotechnology (WBBiB UJ), took place from February
23rd to 27th. It was dedicated to the memory
of prof. Zygmunt Wasylewski, his work, and
scientific research.
The symposium program included 11 lecture sessions and
2 poster sessions, during which 26 lectures and 16 presentations were given, and 48 posters were displayed. The posters were assessed by prof. Grzegorz Bartosz, dr Justyna
Drukała, dr hab. Artur Jarmołowski, and prof. Mariusz Jaskólski. After a boisterous debate, the judges decided to
award the first prize to Joanna Szymak (Department of
Cell Biochemistry of WBBiB UJ), for her work entitled “Obtaining anti-ADAM17 antibody fragments (scFv) by phage
display technique”. Three other works were awarded a ‘honorable mention’: “Phenotypic heterogeneity and metastability of human lung A549 adenocarcinoma cell line” by Iga
Bechyne, M.Sc. from Department of Cell Biochemistry
WBBiB UJ, ”The keys to pluripotency – will iPS replace
ES?” by Monika Maleszewska from Mygen Students’
Scientific Organisation, and “PCNA response to the local
oxidative damage in cell nucleus” by Katarzyna Kędziora
from Division of Cell Biophysics WBBiB UJ.
On the occasion of Winter School Jubilee, prof.. Kazimierz
Strzałka, the Dean of the Faculty, prepared a short presentation on the history of Winter Schools. Afterwards, the par-
89
Among the participants were: prof.
ticipants of preceding seminars went down the memory la-
Grzegorz
ne, and talked about the previous meetings (originally held
Bartosz
(University
of
Łódź), prof. Czesław Cierniewski
in Rabka, then in Zakopane).
(Medical University of Łódź), prof.
Wiesław Gruszecki (Maria Curie-
The organisers of the conference did not forget about Bio-
Skłodowska University), dr Tad Ho-
technology Students’ Scientific Organisation "Mygen": du-
lak (Max Planck Institute of Bioche-
ring
one-hour-long
presentation,
Mygen
members
mistry), dr hab. Artur Jarmołowski
presented report on their achievements. After the presenta-
(Adam Mickiewicz University), prof.
tion students announced the results of "The Most Outstan-
Mariusz Jaskólski (Adam Mickie-
ding Worker of WBBiB" competition. The winners are:
wicz University), prof. Włodzimierz
• for the most vivid lecture – dr. Sylwia Kędracka-Krok
Krzyżosiak (Institute of Bioorganic
• for the fastest exam – prof. Andrzej Klein
Chemistry of Polish Academy of
• for the most complicated way to obtain the credit – ‘Bio-
Sciences), dr hab. Krzysztof Lewiń-
chemistry’ team
ski (Jagiellonian University), prof.
• for the biggest number of textbooks published – prof. An-
Krzysztof
drzej Kozik
Liberek
(University
of
Gdańsk), prof. Grzegorz Węgrzyn
• for the most exciting exam – prof. Halina Gabryś
(University of Gdańsk), and prof.
• for the biggest number of students retaking the exam –
Maciej Żylicz (International Institute
prof. Halina Gabryś
of Molecular and Cell Biology). Alto-
• for the best English-Polish translation – prof. Jan Potempa
gether, more than 170 persons took
• Miss of the Faculty – dr. Joanna Kozieł
part in the Winter School.
• Mister of the Faculty – dr. Andrzej Górecki
The 35th Winter School was organi-
On the last day of the School, for the first time, prof. Zyg-
sed by Department of Physical Bio-
munt Wasylewski’s Memorial skiing competition took pla-
chemistry. It was funded by WBBiB
ce.
and sponsors: Selvita Ltd., ElKaBe
Professors & PhD’s, and Students. The winners were:
24
competitors
were
divided
into
two
groups:
Ltd., Merck Ltd.
from the first group – prof. Marta Pasenkiewicz-Gierula
(Department of Computational Biophysics and Bioinformatics) and dr Jerzy Kruk (Departament of Plant Physiology
and Biochemistry), among the students the invincible were
Dominika Trembecka (Division of Cell Biophysics), and Michał Gwizdała (Department of Biophysics).
90
EVGN summer school
– on the trail of endothelium in the Wolski
Forest
Between 15th and 19th September in
Przegorzały 4th EVGN (European Vascular
Genomic Network) summer school for
candidates for doctor’s degree meeting was
held. This year its motto was ‘From endothelial
formation to endothelial dysfunction – (EV)
genomics approach’. The meeting was
arranged by the Medical Biotechnology
Institute which is a member of EVGN and
gathered about 700 candidates for doctor’s
degree and 20 magnificent speakers.
The participants could listen to lectures concerning the
biology of blood vessels in many different aspects: starting
with learning the physiology of endothelium and new blood
vessels formation process, through the examinations of
molecular mechanisms of endothelium dysfunctions, to
finish with the genetic therapy of lower limb ischaemic
disease and attempts of cellular treatment of myocardial
infraction. An important element of the school was a direct
interaction of lecturers and candidates for doctor’s degree
both during stormy discussions after the lectures and
numerous but less formal meetings during the permanent
poster session and also several entertaining attractions.
The poster session had lot o viewers. Undoubtedly the
interesting results shown on posters as well as the
perspective of winning the best poster competition were an
effective bait. All of the participants voted for their favorite
poster in a secret ballot. One of the prize-winning posters
was prepared at the Medical Biotechnology Institute and it
concerned the role of heme oxygenase-1 in healing
incised wounds of skin. Despite the fact of the “winter”
weather during this summer school the atmosphere was
really warm which contributed to the integration of
lecturers and candidates for doctor’s degree.
91
Central European Con- The international scientific event “Central Eurogress of Life Science EU- pean Congress of Life Science EUROBIOROBIOTECH 2008
TECH 2008” combined with fair took place in
Krakow between 17 and 19 of October. Congress was co-organized by Jagiellonian University (Faculty of BBB, and Collegium Medium),
Agricultural University of Krakow, Polish Federation of Biotechnology and Trade Fairs in Krakow.
Congress was held under the honorable patronage of: Minister of Health, Voivodship Governor and Marshal of Malopolska, President of Krakow, Presidents of Jagiellonian
and Agricultural University of Krakow, Polish Academy of
Learning, Slovak Academy of Sciences, Biotechnology
Committee PAS, Polish Patent Office, Consul-General of
Slovak Republic, Consul-General of Czech Republic and
British-Polish Chamber of Commerce. Moreover, the members of the Honorary Scientific Committee were 27 outstanding scientists from Poland, Lithuania, Czech, Ukraine,
Germany, Russia, Slovakia and Belarus.
EUROBIOTECH 2008 Congress was a continuation of a
very successful “First International Conference: Biotechnology in Agriculture EUROBIOTECH 2007”, held in Krakow
in April 2007. The subject of congress was this time dedicated to broader issues of life sciences with a special focus
on
red
biotechnology.
The
Congress
Program
contained 7 themes:
- Medical Biotechnology
- Pharmaceutical Biotechnology
- Food for Life – Nutrigenomics
- Animal Biotechnology
- Biomaterials
- Intellectual Property Rights and Red Biotechnology
- Searching for Private Capital for Life Sciences Projects
92
Congress Organizing Committee in-
Furthermore, an interesting discussion “Life Science Open
cluded:
Strzałka
Space” was held under the patronage of Cluster Life Scien-
(chairperson, FBBB, JU), prof. Hen-
ces Krakow. It was conducted by the Canadians and Po-
prof.
Kazimierz
ryk Kołoczek (vice-chairperson, AU
lish moderators. Its aim was an exchange of thoughts and
of Krakow) and prof. Tomasz Twar-
opinions on some problems connected with biotechnology.
dowski (PFB) as well as Ms Ewa
The crucial issue discussed was the innovation in science
Woch (Trade Fairs in Krakow). The
and the problem of overcoming the barriers in transferring
Committee
also:
the scientific knowledge into practical applications. Likewi-
(Biotechnology
se, both the “Intellectual Property Rights and Red Biotech-
Committee at Polish Academy of
nology” and “Searching for Private Capital for Life
prof.
S.
members
Bielecki
were
Sciences), Mr P. Błachno (Jagiello-
Sciences Project” panels were very popular, demonstra-
nian Centre of Innovation, JU),
ting an increasing interest in the matters of technology
prof. M. Błażewicz (AGH University
transfer between science and practice.
of Science and Technology),
prof.
A. Dembińska-Kieć (CM JU), prof.
The Congress gathered 480 participants from 21 coun-
J. Dulak (FBBB, JU), prof. K. Kono-
tries, mainly from Europe, but also from America, Asia and
nowicz
(CM JU), prof. P. Laidler
Australia. 140 plenary and session lectures were presen-
(CM JU), dr K. Murzyn (Cluster Life
ted, as well as 190 posters. In the trade part there were 31
Science, Krakow), prof. M. Pawli-
Polish and foreign companies. Their commercial offer was
kowski (AGH University of Science
mainly focused on modern scientific apparatus, reagents
and Technology), prof. P. Pisulew-
and materials, as well as scientific literature. In the accom-
ski (Agricultural University of Kra-
panying exhibition, apart from companies from the “bio-
kow), prof. R. Słomski (Institute of
tech” sector, there were also patent and consulting
Human Genetics, PAN) and prof. Z.
companies as well as investment funds.
Smorąg (National Research Institute of Animal Production, Balice).
Congress was favorably evaluated by the participants. The
invitation of 41 outstanding specialists in particular fields of
biotechnology as the invited speakers guaranteed the high
scientific level of panels.
The Organizing Committee, encouraged by the success of
EUROBIOTECH 2007 and EUROBIOTECH 2008, made
plans about the next congress – Eurobiotech 2010. It will
also take place in Krakow and will be dedicated to white
biotechnology.
93
8. ACTIVE PARTICIPATIONS IN NATIONAL
AND INTERNATIONAL MEETINGS
Gordon
Research
Conferences
Broniec A, Pawlak A, Wrona-Król M, Sarna T, Thomp-
on Oxygen Radicals
son D. Interaction of plasmalogens with singlet oxygen and
Ventura, USA, February 3–8, 2008
peroxyl radicals (poster presentation by T. Sarna)
Korytowski W, Girotti AW. Intermembrane transfer of oxidized phospholipids: cardiolipin peroxidation and recognition
by proapoptotic Bcl-2 family member tBid (poster presentation by W. Korytowski)
Niziołek-Kierecka M, Kriska T, Korytowski W, Girotti AW.
Apoptosis Accommodating Effects of Nitric Oxide in Photodynamically Stressed Tumor Cell (poster presentation by
M. Niziołek-Kierecka)
Insulin resistance – from mole-
Józkowicz A. The effect of PPAR ligands on angiogenesis
cular basis to therapeutic possi-
(invited lecture)
bilities
Białowieża, Poland, February 8–10, 2008
Centre for Biotechnology, Åbo
Dziga D. Growth inhibition of Microcystis aeruginosa in the
Akademi University Conference
presence of macrophyte derived polyphenols (poster pre-
Systems Biology Research Pro-
sentation by D. Dziga)
gram Annual Meeting
Herrankukkaro, Rymättylä, Finland,
February 11, 2008
Intensive Biotechnology Course
Horwacik I. Peptides isolated from phage dislayed libraries
for Students from University Pa-
and their application in design of anti-cancer vaccines (lec-
ris 7 and Faculty of Biochemi-
ture)
stry,
Biophysics
Biotechnology
of
and
Jagiellonian
University
Cracow, Poland, February 11–15, 2008
95
Mitteldeutsches Pflanzenphysiolo-
Banaś AK, Krzeszowiec W, Gabryś H. Does sugar inhibi-
gie-Treffen
tion of chloroplast movements result from stress signaling
and
Symposium
on
Plant Signal Transduction (SFB
(oral presentation by AK. Banaś)
604)
Sztatelman O, Waloszek A, Ziemianin A, Gabryś H. Pho-
Jena, Germany, February 22–23, 2008
toprotective role of chloroplast movements: in vivo chlorophyll
fluorescence
studies
(poster
presentation
by
O. Sztatelman)
35th Winter School of the Faculty
Baczyński K, Strzałka K, Pasenkiewicz-Gierula M. Con-
of Biochemistry, Biophysics and
struction of thylakoid membrane models (poster presenta-
Biotechnology of the Jagiello-
tion by K. Baczyński)
nian
Barbasz A, Kozik A. The assembly and activation of the
University
Structure
and
function of proteins and nucleic
kinin-forming cascade on human macrophages (oral pre-
acids
sentation by A. Barbasz)
Zakopane, Poland, February 23–27, 2008
Bechyne I, Sroka J, Madeja Z, Czyż J. Phenotypic heterogeneity and metastability of human lung A549 adenocarcinoma cell line (poster presentation by I. Bechyne)
Biśta M, Kowalska K, Krajewski M, Czarny A, Popowicz GM,
Dubin A, Holak TA. NMR for the anticancer drug design (oral presentation by M. Biśta)
Budzyńska P, Dymek B, Mizgalska D, Węgrzyn P,
Koj A, Jura J. Differential display of transcripts in HepG2
cells overexpressing MCP-induced protein (poster presentation by P. Budzyńska)
Dobrucki JW, Zarębski M, Wiernasz E. Heterochromatic
protein 1 – a new job for the old fellow? (lecture by J. Dobrucki)
Dubin G, Steć-Niemczyk J, Kisielewska M, Pustelny K,
Popowicz G, Kantyka T, Biśta M, Boulware K.T, Daugherty P.S, Stennicke H.R, Thornberry N, Czarny A, Dubin A,
Potempa J. SplB, a highly specyfic serine endopeptidase
from Staphylococcus aureus (oral presentation by G. Dubin)
Dulak J. New strategies of cell therapy (invited lecture)
Dziedzicka-Wasylewska M, Łukasiewicz S, Faron-Górecka A, Polit A, Górecki A, Tworzydło M, Wasylewski Z.
96
Fluorescence studies reveal hetero-dimerization of dopamine D1 and D2 receptors in the plasma membrane (lecture
by M. Dziedzicka-Wasylewska)
Fic E, Dziedzicka-Wasylewska M, Wasylewski Z. cAMP
receptor protein (CRP) from Escherichia coli as a model of
the transcription activator (lecture by E. Fic)
Gałan W, Bereta J. Computer-assisted analysis of murine
ADAM17 gene promoter and 5’-upstream region (poster
presentation by W. Gałan)
Gołda A, Kozik A. Oxidative modification of the structure
and functions of human kininogens (oral presentation by
A. Gołda)
Gołębiowski F, Zabłocka K, Kowalczyk E, Bonarek P,
Górecki A. Human Yin Yang 1 transcription factor – purification and activity of recombinant protein expressed in
E. coli (poster presentation by F. Gołębiowski)
Guevara-Lora I, Czosnek C, Smycz A, Janik J.F, Kozik A. Binding of biologically active substances onto SiC
nanoparticles (oral presentation by I. Guevara-Lora)
Gozdecka M, Walczyński J, Skrzypek K, Zagórska A, Jaźwa A, Kieda C, Józkowicz A, Hérault Y, Dulak J. The production of transgenic mice with heme oxygenase-1
overexpression in the skin (oral presentation by K. Skrzypek)
Kałużny A, Dawidowski D, Bonarek P, Górecki A. Spectroscopic studies of human TF2B protein interaction with
promotor sequences (poster presentation by A. Kałużny)
Karkowska J, Rąpała-Kozik M, Kozik A. Activation of the
kinin-generating system at the cell surface of Candida species (oral presentation by J. Karkowska)
Kędracka-Krok S, Fic E, Jankowska U, Jaciuk M, Kuśmider M, Gruca P, Papp P, Dziedzicka-Wasylewska M. Proteomic
analysis
of
protein
changes
developing
after
administration of imipramine in the rats hippocampus subjected to chronic mild stress (poster presentation by S. Kędracka-Krok)
97
Kisielewska J, Ligęza J. Tyrphostins 1024 and AG1024 in
the investigation of autocrine growth of cancer cells (oral
presentation by J. Kisielewska)
Kolasińska M, Pezda K, Ramenda A, Banaś AK, Gabryś H. Phototropins – blue light sensors in the world of
plants (poster presentation by A. Ramenda)
Korohoda W, Wilk A. Electrofusion, electroporation and
electrostimulation of endocytosis in cell biology, biotechnology and medicine (lecture by W. Korohoda)
Kosz-Vnenchak M, Kosińska A, Kopeć J, Zawilińska B.
Detection of specific EBV transcripts can help to distinguish between latent and productive infection (poster presentation M. Kosz-Vnenchak)
Król E, Świerczek M. Splitting gene and changing heme
iron ligands in cytochrome b of cytochrome bc1 from purple bacteria (poster presentation by M. Świerczek)
Łoboda A, Stachurska A, Boesch-Saadatmandi Ch, Rimbach G, Józkowicz A, Dulak J. Effect of ochratoxin A on
kidney cells transcriptome – role of Nrf2 transcription factor (oral presentation by A. Stachurska)
Maleszewska M, Szade K, Marek A
Stępniewski J.
The keys to pluripotency – will iPS replace ES? (poster presentation by K. Szade)
Nowakowska N, Bzowska M, Bereta J. Phage display in
production of specific monoclonal antibodies fragments
(poster presentation by N. Nowakowska)
Popik M, Michalczyk D, Salwinski A, Płonka PM.
1-methylnicotinamide (MNA+) as a potent antidystrophic
agent and a modulator of hair cycling in the murine
C57BL/6 hair follicle (poster presentation by M. Popik)
Popiołek K, Sznilik K, Mężyk-Kopeć R, Węgrzyn P,
Koj A, Jura J. Mimitin as a modulator of cell viability (poster presentation by K. Popiołek)
Pustelny K, Steć-Niemczyk J, Dubin G, Kisielewska M,
Boulware KT, Daugherty PS, Stannicke HR, Popowicz G,
98
Potempa J, Dubin A. Characterization of SplA, a highly
substrate specific protease of Staphylococcus aureus (oral
presentation by B. Władyka)
Rak M, Wybieralska E, Różański I, Masnyk M, Chmielewski M, Łysek R, Chojnacki T, Jankowski W, Ciepichal E,
Swiezewska E, Tekle M, Dallner G, Madeja Z. New cationic polyprenyl derivative proposed as a lipofecting agent
(poster presentation by M. Rak)
Rąpała-Kozik M, Olczak M, Ostrowska K, Soroka J, Bocheńska O, Kozik A. Site-directed mutagenesis of the bifunctional
THI3
protein
(phosphomethylpyrimidine
kinase/thiamine phosphate synthase) involved in thiamine
(vitamin B1) biosynthesis pathways in Zea mays (oral presentation by M. Rąpała-Kozik)
Skalniak Ł, Zarębski A, Koj A, Jura J. NFkappaB-madiated up-regulation of Monocyte Chemotactic Protein-1-Induced Protein (MCPIP) after Interleukin-1beta stimulation
(poster presentation by L. Skalniak)
Sobiecka-Szkatuła A, Polit A, Skórko-Glonek J, Sire A,
Fanfani F, Lipińska B. Characterization of the intramolecular interactions occuring during
activation mechanizm of
HtrA protease from E. coli (poster presentation by A. Sobiecka-Szkatuła)
Sroka J, Włosiak P, Wilk A, Antonik J, Czyż J, Madeja Z.
The effect of tributyltin on human eosinophylic leukemia
EoL-1 cells (poster presentation by J. Sroka)
Szymak J, Zaionc M, Bzowska M, Bereta J. Obtaining
anti-ADAM17 antibody fragments (scFv) by phage display technique (poster presentation by J. Szymak and
M. Zaionc)
Taha HM, Guevara-Lora I, Exner M, Mustafa S, Nigisch A,
Balcerczyk A, Weigel G, Ferdek P, Skrzypek K, Dulak J,
Józkowicz A. Role of heme oxygenase-1 in endothelial
cells-lesson from the promoter polymorphism (oral presentation by A. Józkowicz)
99
Władyka B, Rojowska A, Kozik A, Dubin A. Inhibition of
staphopain A2 by alpha-1-antichymotrypsin – a double surprise (oral presentation by B. Władyka)
TOP Congress; Symposium of
Pyrć K. New viruses: the discovery of human coronaviru-
Society for Infectious Disease
ses (invited lecture)
Utrecht, Holland, March 6, 2008
25th Winter School on Proteolytic
Potempa J. A Unique Secretion Pathway of Proteases in
Enzymes
Periodontal Pathogens (invited lecture)
Tiers, Italy, February 27–March 2, 2008
COST Action meeting CM0602
Dulak J. Targeting heme oxygenase-1 for anti-cancer the-
(European
rapy (lecture)
Cooperation
in
the
Field of Scientific and Technical
Florczyk U, Gołda S, Zięba A, Cisowski J, Józkowicz A,
Research) Inhibitors of angioge-
Dulak J. Overexpression of biliverdin reductase enhances
nesis: design, synthesis and bio-
heme oxygenase-1 expression, activates ERK1, JNK1 and
logical exploitation
p38 kinases and ensures partial protection against chemo-
Molsheim
(Strasburg),
France,
March 8, 2008
therapeutics (oral presentation by U. Florczyk)
Gołda S, Jaźwa A, Majka M, Boczkowski J, Józkowicz A,
Dulak J. Overexpression of HO-1 attenuates proliferation,
angiogenesis and metastasis of human lung cancer (poster presentation by S. Gołda)
Conference on Molecular Simula-
Murzyn K, Pasenkiewicz-Gierula M. Molecular simulations
tions in Biosystems and Material
of lipid-A, POPE, and lipid-A/POPE bilayers (poster presen-
Science (SimBioMa)
tation by M. Pasenkiewicz-Gierula)
Konstanz, Germany, April 2–6, 2008
Markiewicz M, Pasenkiewicz-Gierula M, Serda P, Librowski T, Marona H, Hodorowicz S. Non-steroidal anti-inflammatory drugs interactions with membrane – a molecular
dynamics and X-ray diffraction study (poster presentation
by M. Markiewicz)
Martinez-Seara H, Róg T, Pasenkiewicz-Gierula M, Vattulainen I, Karttunen M, Reigada R. Effect of double bond position in unsaturated phosphatidylcholine bilayers (poster
presentation by H. Martinez-Seara)
100
4th International Conference for
Tomasik J, Kityk R, Piróg A, Kędracka-Krok S, Fic E,
Student and PhD Students Youth
Dziedzicka-Wasylewska M. Initial purification and enrich-
and progress in biology
ment of phosphorylated proteins in proteome anaysis (po-
Lviv, Ukraine, April 7–10, 2008
ster presentation by J. Tomasik and R. Kityk)
ERA-Chemistry Workshop
Gabryś H. Photomorphogenesis and biomass production
Cracow, Poland, April 13–16, 2008
(lecture)
Conference "Focus on Microscopy"
Dobrucki JW, Trembecka D, Kuzak M. Quantitative
Osaka-Awaji, Japan, April 13–16, 2008
FRAP – the role of photon flux and the limits imposed by
photodamage (lecture by JW. Dobrucki)
Dobrucki JW. Imaging extracellular matrix in vivo, using
a new fluorescent probe Col-F (lecture)
Conference "Protein structure ini-
Gront D, Chruszcz M, Śledź P, Zheng H, Murzyn K, Mi-
tiative 'bottlenecks' workshop"
nor W. Small molecule agents in protein structures (poster
Bethesda, Maryland, USA, April 14–16, 2008
presentation by K. Murzyn)
The
Nowak W, Dörk T, Pietrucha B, Cukrowska B. Novel kina-
International
Ataxia-Telan-
giectasia Workshop
se-dead mutation in Polish AT patient (poster presentation
Ohtsu, Japan, April 22–26, 2008
by W. Nowak)
Pietrucha B, Heropolitanska E, Cukrowska B, Arasimowicz E, Nowak W, Bernatowska E, Gatti RA. Clinical and
molecular study of 45 Polish patients with ataxia-telangiectasia syndrome (poster presentation by W. Nowak)
Biophysical methods in experi-
Myśliwa-Kurdziel B. Aplication of fluorescent methods in
mental biology of plants
plant experimental biology. (oral presentation by B. Mysli-
Kazimierz Dolny, Poland, April 24, 2008
wa-Kurdziel)
2nd Łódź Philosophical Workshop
Korzeniewski B. Language thinking in writings of Stani-
Łódź, Poland, April 25–26, 2008
sław Lem (lecture)
Conference
Pieniążek E, Jura J, Murzyn K. Comparative modeling of
on
Bioinformatics
2008
the human PIN domain from MCPIP protein (poster presenta-
Warsaw, Poland, April 24–27, 2008
tion by E. Pieniążek)
101
Mordarski J, Murzyn K. Relational model of bibliographic
data from NCBI PubMed database (poster presentation by
J. Mordarski)
Sikora M, Pasenkiewicz-Gierula M, Lewiński K. Molecular dynamics simulation of RNase A at high pressure (poster presentation by M. Sikora)
2008 Annual Meeting of ARVO
Sarna T, Żądło A, Burke JM. The effect of photobleached
Fort Lauderdale, USA, April 27
and untreated bovine RPE melanosomes on photoinduced
–May 1, 2008
peroxidation of lipids (poster presentation by T. Sarna)
Zaręba M, Burke JM. Sub-lethal photic stress impairs organelle translocation in RPE cells (poster presentation by
M. Zaręba)
13th Congress of Polish Society
Dulak J. Role of heme oxygenase-1 and Nrf2 transcription
of Experimental and Clinical Im-
factor in regulation of the inflammatory cytokines in endo-
munology
thelial cells (invited lecture)
Cracow, Poland, May 14–17, 2008
Frączek J, Kim TW, Yao J, Wen Q, Xiao H, Casanowa JL,
Pryjma J, Li X. The kinase activity of Irak4 is required for
Il-1r/tlr-induced TAK1-dependent NF-kB activation and normal production of proinflammatory cytokines (poster presentation by J. Frączek)
Friedlein G, Dzięba M, Kędzierska A, Klepacka J, Pryjma J. Apoptosis of monocytes and macrophages after
phagocytosis of staphylococcus aureus and treatment with
supernatants from bacterial culture (poster presentation by
G. Friedlein)
Gałan W, Bereta J. Computer-assisted analysis of murine
ADAM17 gene promoter and 5’-upstream region (poster
presentation by W. Gałan)
Horwacik I, Kowalczyk A, Czaplicki D, Rokita H. Analysis of
anti-GD2 ganglioside humoral response induced with GD2
peptide mimics in mouse models (oral presentation by I. Horwacik)
Kasza A, Wyrzykowska P, Horwacik I, Jura J, Bereta J.
IL-1 regulates the expression of MCPIP by ELK-1 (poster
presentation by A. Kasza
102
Kędzierska A, Kapińska-Mrowiecka M, Mikołajczyk T,
Czubak-Macugowska M, Pryjma J. Expression of CD36
and production of TNF-alpha by monocytes from atopic
dermatitis patients (poster presentation by A. Kędzierska)
Kowalczyk A, Gil M, Odrowąż Ż, Horwacik I, Kozbor D,
Rokita H. The GD2-specific 14G2a monoclonal antibody
induces apoptosis and enhances cytotoxicity of chemotherapeutic drugs in IMR-32 human neuroblastoma cells (oral
presentation by H. Rokita)
Kulig P, Stefańska A, Kantyka T, Wawro K, Oleszycka E,
Zabel BA, Potempa J, Butcher EC, Cichy J. Activators of
plasma chemoattractant chemerin (oral presentation by J. Cichy)
Łoboda A, Stachurska A, Florczyk U, Rudnicka D, Jaźwa
A,
Węgrzyn
J,
Kozakowska M,
Stalinska
K,
Levonen A-L, Yla-Herttuala S, Józkowicz A, Dulak J.
HIF-1 induction attenuates Nrf2-dependent IL-8 production
in human endothelial cells independently of HO-1 (poster
presentation by A. Łoboda)
Mizgalska D, Węgrzyn P, Murzyn K, Koj A, Jura J.
MCPIP as a modulator of inflammatory response (poster
presentation by D. Mizgalska)
Mikołajczyk T, Skrzeczyńska-Moncznik J, Bzowska M,
Zarębski M, Dobrucki J, Pryjma J. CD16+ monocytes
are responsible for recognition and ingestion of apoptotic
granulocytes
(oral
presentation
by
T.
Mikołajczyk)
Skalniak Ł, Zarębski A, Koj A, Jura J. NFkappaB-mediated up-regulation of Monocyte Chemotactic Protein-1-Induced Protein (MCPIP) after Interleukin-1beta stimulation.
(poster presentation by Ł. Skalniak)
Szymak J, Zaionc M, Bzowska M, Bereta J. Obtaining
anti-ADAM17 antibody fragments (scFv) by phage display
technique (poster presentation by J. Szymak)
Tymoszuk P, Balwierz A, Bereta J, Kasza A. Tristetraproline is
a new gene regulated by ELK-1 (poster presentation by P. Tymoszuk)
Waś H, Sierpniowska A, Sokołowska M, Cichoń T, Smolarczyk R, Skrzypek K, Dominik P, Ratajska A, Prątnicki A,
103
Lackowska B, Mazur A, Lemke K, Szala S, Dulak J, Józkowicz A. Heme oxygenase-1 (HO-1) affects inflammation related
to
tumor
induction
and
progression
(poster
presentation by H. Waś)
Wawro K, Skrzeczyńska-Moncznik J, Oleszycka E, Kulig P,
Zabel BA, Sułkowski M, Kapińska-Mrowiecka M, Czubak-Macugowska M, Stefańska A, Butcher EC, Cichy J. Role of chemerin in controlling recruitment of plasmacytoid dendritic cells to
diseased skin (oral presentation by J. Cichy)
27th Conference of Embryology
Pilarska M, Słomka A, Rataj K, Pawełek-Skoczylas A, Ilnic-
Plants, animals, humans
ki T, Kuta E, Malec P. Developmental biology of Arabidopsis thaliana At1g67580 mutant (poster presentation by
Wisła, Poland, May 14–17, 2008
M. Pilarska)
International Scientific Conferen-
Strzałka K, Widomska J. Polar carotenoids as stabilizers
ce "Bioecological problems and
in lipid membrane (abstract)
means of solution (Second Rzhavitin Readings)", Mordovian State University
Saransk, Russia, May 15–18, 2008
Conference Biological Membranes
Szklarska
16–18, 2008
Poręba,
Poland,
May
Baczyński K, Strzałka K, Pasenkiewicz-Gierula M. Investigations on structural properties of molecular models of
thylakoid membrane. (poster presentation by B. Baczyński)
Jemioła-Rzemińska M, Suwalsky M, Strzałka K. Interactions between small molecules and phospholipids in model
membranes studied by differential scanning calorimetry (poster presentation by M. Jemioła-Rzemińska)
Korohoda W. New research problems and new ways of studying them in cell biology, cell biochemistry and cell biophysics (invited lecture)
Kostecka-Gugała A, Latowski D, Widomska J, Gruszecki W. I, Strzałka K. The influence of a carotenoid structure
on the physical properties of model membranes (poster presentation by A. Kostecka-Gugała)
104
Markiewicz M, Pasenkiewicz-Gierula M, Serda P, Librowski T, Marona H, Hodorowicz S, Non-steroidal anti-inflammatory drugs interactions with membrane: experimental and
computational analysis. (poster presentation by M. Markiewicz)
Pasenkiewicz-Gierula M. Computer model of a lipid bilayer (lecture by M. Pasenkiewicz Gierula)
Rak M, Wybieralska E, Różański I, Masnyk M, Chmielewski M, Łysek R, Chojnacki T, Jankowski W, Ciepichal E, Swieżewska E, Tekle M, Dallner G. Sroka J, Madeja Z. Aplication of
cationic poliprenol derivatives in lipofection (poster presentation by
M. Rak)
Szczygieł M, Fiedor L, Urbańska K. Uptake and localization of
chlorophilide photosensitizers in S91 melanoma cells (poster presentation by M. Szczygieł)
Widomska J, Raguz M, Subczyński WK. Physical properties of
the lens lipid bilayer. EPR spin labeling studies (poster presentation by J. Widomska)
Widomska J, Subczyński WK, Gruszecki WI, Strzałka K.
The effect of isomeric forms of zeaxanthin on the structure and
thermotropic phase behavior of model dipalmitoylphosphatidylcholine bilayers (poster presentation by J. Widomska)
24th International Congress of Socie-
Trembecka D, Kuzak M, Dobrucki J. Quantitative Fluore-
ty for Analytical Cytology Cytometry
scence Recovery After Photobleaching (FRAP): the role of
in the age of systems biology
photon flux and object translocation (poster presentation
Budapest, Hungary, May 17–21, 2008
by D. Trembecka)
Wójcik K, Dobrucki J. Influence of antitumor drug daunomycin
on histone-DNA interactions (poster presentation by J. Dobrucki)
42nd Zakopane School of Physics
Harańczyk H, Bacior M, Jamróz J, Strzałka K. Rehydration of
Breaking frontiers: submicron struc-
DGDG (digalactosyl diacylglycerol) model membrane lyophiliza-
tures in physics and biology
tes observed by NMR and sorption isotherm (poster presenta-
Zakopane, Poland, May 19–24, 2008
tion by K. Baczyński)
Harańczyk H, Leja A, Strzałka K. Maturation process of photosynthetic membranes observed by proton magnetic relaxation
and sorption isotherm (oral presentation by H. Harańczyk)
105
Advances in neuroblastoma
Czaplicki D, Horwacik I, Kowalczyk A, Gołda A, Wieczorek
research
A, Bolek-Marzec K, Balwierz W, Kozik A, Rokita H. Gangliosi-
Chiba, Japan, May 21–24, 2008
de content in blood serum of neuroblastoma patients (poster presentation by D. Czaplicki)
38th Mid-Atlantic Macromolecular
Porębski P, Murzyn K, Chruszcz M, Xu X, Cymborowski M, Sa-
Crystallography Meeting
vchenko A, Edwards A, Minor W, Subtle shades of structural dif-
Chapel Hill, USA, May 22–24, 2008
ferences between H. pylori and E. coli dethiobiothin synthetases
(poster presentation by K. Murzyn)
2nd Conference of Eye Oncology
Nowak-Śliwińska P, Sawow A, Elas M, Matuszak Z, Kubicka-
Cracow, Poland, May 23–24, 2008
Trząska A, Romanowska-Doxon B, Urbańska K. Indocyanine
and verteporphin as photosensitizers in photodynamic therapy
(lecture by K. Urbańska)
Sawow A, Matuszak Z, Elas M, Romanowska-Dixon B, Urbańska K. Early and late effects of brachytherapy in experimental
melanoma model (lecture by K. Urbańska)
Wójcik A, Matuszak Z, Elas M, Romanowska-Dixon B, Miodoński A, Urbańska K. Fractal analysis of tumor vasculature
after radiophototherapy (lecture by K. Urbańska)
Conference The seventeenth days
Faron-Górecka A, Górecki A, Kuśmider M, Grymek K, Dzie-
of neuropsychopharmacology
dzicka-Wasylewska M. Comparison of effects of antipsychotic
Ustroń–Jaszowiec, Poland,
drugs on dopamine D1 and D2 receptor interaction in the HEK
May 26–28, 2008
293 cells (poster presentation by A. Faron-Górecka)
17th
International
Symposium on
Physiology and Regulation in Cells
Międzobrodzki J. How and why Staphylococcus aureus bacteria communicate each other? (invited lecture)
Cracow, Poland, June 4–5, 2008
17th International Symposium of Po-
Drukała J. Epidermal stem cells in tissue engineering (invi-
lish Network of Molecular and Cellu-
ted lecture)
lar Biology UNESCO/PAS Molecular
Holko P, Klein A, Kordowiak A. Does bis(maltolato)oxovana-
and physiological aspects of regula-
dium(IV) [BMOV] acts as antitumorogenic agent on human pan-
tory processes of the organism
creatic cancer cell line PANC-1? Preliminary investigations
(poster presentation by P. Holko)
106
Korohoda W, Wilk A. Problems due to heterogenity of cancer cells population and their solutions (invited lecture by
W. Korohoda)
Ligęza J, Kisielewska J, Klein A. The effect of tyrosine kinase
inhibitors, tyrphostins: AG1024 and SU1498, on autocrine
growth of pancreatic cancer cells (PANC-) (poster presentation
by J. Ligęza)
8th Meeting of France-New EU Mem-
Wyrzykowska P, Kasza A. Biomarker of vascular dise-
bers/16th JMRC Symposium New
ases PAI-1, is regulated by MAP kinases via Elk-1 trans-
frontiers in cardiovascular research
cription factor (poster presentation by A. Kasza)
3D Confocal Microscopy Course
Dobrucki JW. Photobleaching and phototoxicity (invited
Vancouver, Canada, June 13–25, 2008
lecture)
Lublin Virusology Days
Zawilińska B, Kopeć J, Daszkiewicz E, Piątkowska-Jaku-
Lublin, Poland, June 19–21, 2008
bas B, Skotnicki A, Lenart M, Krzemień P, Kosz-Vnenchak M. Chronic and recurrent CMV infection in allo- HSCT
recipients (oral and poster presentation by B. Zawilińska)
34th Meeting of the American So-
Burke J, Sarna T, Szewczyk G, Żądło A, Zaręba M. Bio-
ciety for Photobiology
physical properties of photobleached porcine and cow
San Francisco, USA, June 20–25,
RPE melanosomes – an in vitro model of aged human
2008
RPE melanosomes (lecture by T. Sarna)
Gordon
Research
Conference
Photosynthesis
Fiedor L. Molecular determinants of assembly and functioning of photosynthetic antenna complexes (invited lecture)
Mount Holyoke College, Holyoke,
USA, June 22–27, 2008
15th International Symposium on
Strzałka K, Goss R, Latowski D, Grzyb J, Lohr M, Aker-
Carotenoids
lund H, Wilhelm Ch, Vieler A. Xanthophyll de-epoxidases –
Okinawa, Japan, June 22–27, 2008
a new group of enzymes requiring lipid inverted hexagonal
phases (lecture by K. Strzałka )
107
Subczyński WK, Widomska J. Transmembrane localization of cis-isomers of zeaxanthin (poster presentation by
W.K. Subczyński)
National Nanotechnology Confe-
Guevara-Lora I, Czosnek C, Smycz A, Janik JF, Kozik A.
rence
Nanocząstki Sic jako potencjalne nośniki dla wiązania sub-
stancji biologicznie aktywnych (poster presentation by
C. Czosnek)
33rd FEBS Congress – 11th IUBMB
Czyż J, Bechyne I, Baran B, Sroka J, Madeja Z, Sie-
Conference
dlar M, Zembala M. Tumour necrosis factor (TNF) secre-
Athens, Greece, June 28–July 3, 2008
ted by monocytes mediates the induction of human
pancreatic carcinoma (HPC-4) cell migration in co-cultures
(poster presentation by J. Czyż)
Guevara-Lora I, Stalińska K, Florkowska M, Barbasz A.
Kinins modulate STATs activation in human macrophages
(poster presentation by I. Guevara-Lora)
Kozik A, Karkowska J, Rąpala-Kozik M. The binding and
activation of the host kinin-generating system on the cell
walls of pathogenic Candida species (poster presentation
by A. Kozik)
Kozik A, Kowalska E. The up-regulation of thiaminesynthesizing, activating and utilizing enzymes in baker’s
yeast under conditions of oxidative stress (poster presentation by A. Kozik)
20th Meeting of the European Asso-
Horwacik I, Kowalczyk A, Bzowska M, Czaplicki D, Ro-
ciation for Cancer Research
kita H. Probing the molecular mechanizm of GD2 ganglio-
Lyon, France, July 5–8, 2008
side mimicry with 12-amino acid constrained peptides
(poster presentation by I. Horwacik).
Gordon Research Conference
Kulig P, Stefańska A, Kantyka T, Wawro K, Oleszycka E,
New London, USA, July 6–11, 2008
Zabel BA, Potempa J, Butcher EC, Cichy J. Cysteine protease activators of plasma chemoattractant chemerin (poster presentation by J. Cichy)
108
20th International Congress of Ge-
Mizgalska D, Węgrzyn P, Murzyn K, Koj A, Jura J.
netics
MCPIP as a protein with RNAse properties (lecture by
Berlin, Germany, July 12–17, 2008
D. Mizgalska)
15th European Bioenergetic Con-
Korzeniewski B. Application of parallel activation appro-
ference
ach to oxidative phosphorylation (poster presentation)
Dublin, Ireland, July 19–24, 2008
Korzeniewski B. 17 reasons to believe in parallel activation of oxidative phosphorylation (poster presentation)
Sarewicz M, Borek A, Daldal F, Froncisz W, Osyczka A.
Estimation of the lifetime of the complex between cytochrome c and cytochrome bc1 using electron paramagnetic resonance (lecture by A. Osyczka)
Zhang H, Osyczka A, Chobot SE, Dutton, PL, Moser CC.
The Qo site semiquinone state in isolated cytochrome bc1
(complex III) from Rhodobacter capsulatus (poster presentation by A. Osyczka)
33rd
International
Herpesvirus
Szostek S, Zawilińska B, Klimek M, Kosz-Vnenchak M.
Workshop
The correlation between selected herpesviruses and papil-
Estoril, Porugal, July 27–August 1,
lomaviruses infection in women with cervical abnormalities
2008
and cancer (poster presentation by M. Kosz-Vnenchak)
Zawilińska B, Krzemień P, Daszkiewicz E, Kopeć J, KoszVnenchak M. The contribution of EBV, HHV6, and HHV7
in chronic or recurrent CMV infection in bone marrow transplant recipients (poster presentation by M. Kosz-Vnenchak)
Banff Conference on Plant Meta-
Strzałka K. Xanthophyll de-epoxidases – a new group of
bolism
enzymes requiring lipid inverted hexagonal phases – (po-
Banff, Canada, July 30–August 3, 2008
ster presentation)
Microscopy and Microanalysis
Wójcik K, Dobrucki J. Confocal microscopy reveals mole-
Albuquerque,
USA,
August
3–7,
cular interactions between DNA-binding drugs and chroma-
2008
tin in live cells (invited lecture by J. Dobrucki)
The 13th Workshop of the Internatio-
Deschodt-Arsac V, Korzeniewski B, Calmettes G, Dio-
nal Study Group for Systems Biology
lez PH. Supply-demand: an experimental view of the rela-
109
Elsinore, Denmark, August 17–20,
tionship between elasticities and homeostasis from Modu-
2008
lar Control Analysis (lecture by B. Korzeniewski)
Deschodt-Arsac V, Korzeniewski B, Calmettes G, Franconi JM, Diolez PH. Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply
(poster presentation by B. Korzeniewski)
Dzbęk J, Korzeniewski B. Contribution of the mitochondial membrane potential and proton gradient to the protonmotive force (poster presentation by B. Korzeniewski)
Korzeniewski B. Regulation of oxidative phosphorylation
through parallel activation (lecture)
Liguziński P, Korzeniewski B. Oxygen delivery by blood
determines the maximal VO2 during whole body exercise
in humans (poster presentation by B. Korzeniewski)
236th ACS National Meeting
Bruns N, Pustelny K, Clark D. Mechanical nanosensor ba-
Philadelphia, USA, August 17–21,
sed on a thermophilic thermosome: En route to self-repor-
2008
ting biomateriale (poster presentation by N. Bruns,
K. Pustelny, D. Clark)
16th Congress of FESPB
Czech AS, Strzałka K, Schurr U, Matsubara S. Delayed
Tampere,
greening in Theobroma cacao L (poster presentation by
Finland, August 17–22,
2008
13th
A. Czech)
International
Congress
of
Dobrucki J. Heterochromatic protein 1 and repair of DNA
the Federation of Societies for Hi-
damage – a new job for the old fellow? (invited lecture)
stochemistry and Cytochemistry
Jaźwa A, Sierpniowska A, Kozakowska M, Zagórska A,
"Imaging of Cell Dynamics"
Kucharzewska P, Leja J, Vahakangas E, Yla-Herttuala S,
Gdańsk,
2008
Poland,
August
23–27,
Józkowicz A, Dulak J. AAV-mediated VEGF165 and FGF4 gene transfer for the treatment of hind limb ischemia (poster presentation by A. Jaźwa)
Jaźwa A, Taha HM, Sierpniowska A, Zagórska A, Kucharzewska P, Leja J, Meloni M, Emanueli C, Vahakangas E,
Yla-Herttuala S, Józkowicz A, Dulak J. AAV-mediated
VEGF165 and FGF-4 gene transfer for the treatment of
hind limb ischemia (poster presentation by A. Jaźwa)
110
Waś H, Sierpniowska A, Sokołowska M, Cichoń T, Smolarczyk R, Skrzypek K, Dominik P, Ratajska A, Prątnicki A, Lackowska B, Mazur A, Lemke K, Szala S, Dulak J,
Józkowicz A. Heme oxygenase-1 expression in stromal
cells protects against tumor induction and progression (poster presentation by H. Waś)
Polish Bioethical Society Conferen-
Dulak J. Gene therapy: medical and ethical problems (invi-
ce "Ethical and legislative aspects
ted lecture)
of scientific research"
Cracow, Poland, August 29–31, 2008
11th Symposium on Proteinase In-
Potempa J. Strategies of complement evasion by perio-
hibitors and Biological Control
dontal pathogens, Porphyromonas gingivalis and Prevotella
Portoroz, Slovenia, August 30–Sep-
intermedia (invited lecture)
tember 3, 2008
21st ECNP Congress
Faron-Górecka A, Górecki A, Kuśmider M, Grymek K,
Barcelona, Spain, August 30–Sep-
Dziedzicka-Wasylewska M. Dopamine D1-D2 receptor in-
tember 3, 2008
teractions in the presence of antypsychotic drugs – in vitro
studies (poster presentation by A. Faron-Górecka)
SFRR-E Advanced Training Course
Niziołek-Kierecka M, Kriska T, Korytowski W, Girotti AW.
Lipid peroxidation and free radical-
Apoptosis Accommodating Effects of Nitric Oxide in Photo-
signaling – roles in pathophysiology
dynamically Stressed Tumor Cell (poster presentation by
Spetses
M. Niziołek-Kierecka)
Island,
Greece,
August
30–September 5, 2008
The 7th European Workshop on the
Bozkurt O, Komenda J, Itoh S, Komura M, Czer K, Vass I,
Molecular Biology of Cyanobacteria
Malec P, Gombos Z, Kis M. Carotenoid assisted assembly
Č. Budějovice, Czech Republic, Au-
and functions of the photosynthetic reaction centers in Syne-
gust 31–September 4, 2008
chocystis sp. PCC 6803 (poster presentation by O. Bozkurt)
European Microscopy Conference
Wojcik K, Dobrucki JW. Confocal Microscopy Reveals
Aachen, Germany, September 1–5,
Molecular Interactions Between DNA-binding Drugs and
2008
Chromatin in Live Cells (invited lecture by J. Dobrucki)
111
26th Meeting of Polish Microbiolo-
Kosz-Vnenchak M, Zawilińska B, Kopeć J, Daszkie-
gists Society "Microorganisms –
wicz E, Piątkowska-Jakubas B, Skotnicki A. The influence
challenges and hopes"
of accessory lymphotropic herpesvirus infections on the co-
Szczecin, Poland, September 4–7,
urse of CMV infections in patients after allo-HSCT (poster
2008
presentation by B. Zawilińska)
Kozieł J. Staphylococcus aureus as an intracellular patogen of immune system cells (invited lecture)
Pyrć K. Human coronavirus NL63: clinical picture and molecular characteristics (invited lecture)
Różalska M, Mak P, Maszewska A. Characteristics of synergistic hemolisins produced by two Staphylococcus cohnii subspecies (poster presentation by M. Różalska)
8th International Conference on
Szewczyk G, Ashur I, Goldschmidt R, Pinkas I, Salomon
Pulse Investigations in Biology
Y, Sarna T, Scherz A. Catalytic generation of oxygen radi-
and Physics
cals by a water soluble Pd-bacteriochlorophyll derivative;
Krakow, Poland, September 6–12,
EPR, laser flash photolysis and time-resolved singlet oxy-
2008
gen phosphorescence study (lecture by G. Szewczyk)
Congress of Biochemistry and
Cell Biology.
43rd
Meeting of the
Bechyne I, Sroka J, Madeja Z, Czyż J. A549 adenocarcinoma cells display phenotypic heterogeneity and metasta-
Polish Biochemical Society
bility in culture (poster presentation by I. Bechyne)
Olsztyn, Poland, September 7–11,
Dobrucki J, Kuzak M, Wiernasz E, Zarębski M. Beyond
2008
heterochromatin maintenance - heterochromatic protein 1 involvement in repair of DNA damage (lecture by J. Dobrucki)
Drukała J. Keratinocytes migration in wound healing – clinical implications (invited lecture)
Drukała J, Sarna M, Szymoński M, Madeja Z, Topographical guidance of tumor cells migrating on multiple grooved
substrata (poster presentation by J. Drukała)
Dubin A, Dubin G. Proteases of Staphylococcus aures – from
structure and function to practical application (lecture by A. Dubin)
Dulak J. Antioxidant genes in endothelial progenitor cells
– the significance for therapy (invited lecture)
Dulak J. The interaction between HIF-1 and Nrf2 in the regulation of angiogenic gene expression (invited lecture)
112
Dulak J. Role of Nrf2 transcription factor in oxidative
stress (invited lecture)
Dulak J, Grochot-Przęczek A, Łoboda A, Jaźwa A, Kotlinowski J, Deshane J, Agarwal A, Józkowicz A. Antioxidant genes in endothelial progenitor cells – significance for
therapy (poster presentation by A. Grochot-Przęczek)
Guevara-Lora I, Florkowska M, Sroka J. Regulations of
kinin receptors by agonists and cytokin in monocyte-like
cells of line U937 (poster presentation by I. Guevara-Lora)
Józkowicz A. Role of heme oxygenase in wound healing
EVGN Summer School
Cracow,
2008
Poland,
September
16,
(invited lecture)
Józkowicz A, Taha HM, Grochot-Przęczek A, Waś H,
Kotlinowski J, Kozakowska M, Marek A, Lackowska B,
Balcerczyk B, Dulak J. Modulation of inflammatory response by pentoxifylline is independent of heme oxygenase-1
pathway (poster presentation by A. Józkowicz)
Kędracka-Krok S, Fic E, Kuśmider M, Gruca P, Papp M,
Dziedzicka-Wasylewska M. Proteomic studies of alternations in the hippocampus of rats subjected to chronic mild
stress upon administration of imipramine (poster presentation by S. Kędracka-Krok, E. Fic)
Krzeszowiec W, Banaś AK, Ramenda A, Gabryś H.
ABA and light signaling pathways in chloroplast movements (poster presentation by W. Krzeszowiec)
Sroka J. The role of thioredoxin reductase in the regulation of migration and gap junctional intercellular communication in HEK-293 cells (invited lecture)
Sroka J, Czyż J, Madeja Z. The role of thioredoxin reductase in the regulation of migration and gap junctional intercellular
communication
in
HEK-293
cells
(poster
presentation by J. Sroka)
Sroka J, Czyż J, Wojewoda M, Madeja Z. The inhibitory
effect of diphenyltin on gap junctional intercellular communication in HEK-293 cells is reduced by thioredoxin reductase (poster presentation by J. Sroka)
113
Waś H, Sierpniowska A, Sokołowska M, Cichoń T, Smolarczyk R, Dominik P, Skrzypek K, Ratajska A, Lackowska
B,
Mazur
A,
Lemke
K,
Szala
S,
Dulak
J,
Józkowicz A. HO-1 in host cells – role in tumor induction
and progression (oral presentation by H. Waś)
Wilk A, Korohoda W. Problems due to heterogenity of
cancer cells population and their solutions (invited lecture
by W. Korohoda)
Włodarczyk A, Stawiarska M, Pierzchalska M, Soja J,
Sroka J, Michalik M. Fibroblasts derived from asthmatics
demonstrate enhanced TGFκ stimulated changes in morphology, motility and potential to differentiate into myofibroblasts (poster presentation by A. Włodarczyk)
Józkowicz A. Mechanisms of blood vessel formation, (invited lecture)
Józkowicz A. Social aspects of vascular biology; bioethics, gender issue – an “unconventional” point of view
(invited lecture)
Łoboda A, Rudnicka D, Stachurska A, Jaźwa A, Węgrzyn J, Kozakowska M, Stalinska K, Levonen AL, YlaHerttuala S, Józkowicz A, Dulak J. HIF induction attenuates Nrf2-dependent IL8 production in human endothelial
cells independently of HO-1 (poster presentation by A. Stachurska)
Grochot-Przęczek A, Miś J, Kozakowska M, Kotlinowski J, Dubiel M, Mazan A, Rutkowski A, Kurowski K,
Józkowicz A, Dulak J. Heme oxygenase-1 accelerates
wound healing (poster presentation by A. Grochot-Przęczek)
Józkowicz A, Dulak J. AAV-mediated VEGF165 and FGF4 gene transfer for the stimulation of reparative processes in
the wounded skin of genetically diabetic mice (poster
sentation by A. Jaźwa)
114
pre-
22nd Polish Seminar Mechanisms
Drukała J. Stem cells in wounds healing (invited lecture)
of life support and physiological
Stawiarska M, Włodarczyk A, Sroka J, Pierzchalska M,
regulations
Soja J,
Cracow, Poland, September 20, 2008
and healthy donors differ in growth rate, motility and poten-
Michalik J. Fibroblasts derived from asthmatics
tial to differentiate into myofibroblasts (poster presentation
by M. Stawiarska)
Workshop on Microbiology in He-
Różalska M, Mak P, Maszewska A. Haemolysins of Sta-
alth and Environmental Protection
phylococcus cohni (poster presentation by M. Różalska)
Łódź, Poland, September 25–26, 2008
In Vivo ESR/EPR Spectroscopy
Marino A, Norris JR, D’Ischia M, Napolitano A, Panzella L,
and Imaging and the 10th Interna-
Camenisch TG, Sarna T, Szewczyk G. Time-resolved and
tional EPR Spin Trapping/Spin
high frequency EPR study of natural and synthetic melanin
Labeling Conference
pigments (lecture by T. Sarna)
Fukuoka, Japan, September 28–30,
2008
Conference of Polish Bioethics
Dulak J. Gene therapy – medical and ethical problems.
Society
Ethical and legislatory limitations of scientific research (invi-
Cracow, Poland, September 29–31, 2008
ted lecture)
SEST 2008 (Japanese Society for
Ashur I, Goldschmid R, Inkas I, Salomon Y, Scherz A,
EPR/ESR)
Szewczyk G, Sarna T, Catalytic generation of oxygen radi-
Fukuoka, Japan, October 1–3, 2008
cals by non-covalent bacteriochlorin-serum albumin complexes (plenary lecture by T. Sarna)
3rd ESF Conference on Functio-
Kędracka-Krok S, Fic E, Kuśmider M, Gruca P, Papp M,
nal Genomics and Disease
Dziedzicka-Wasylewska M. Proteomic analysis of prote-
Innsbruck, Austria, October 1–4,
ins changes developing after administration of imipramine
2008
in the rats hippocampus subjected to chronic mild stress
(poster presentation by S. Kędracka-Krok and E. Fic)
Conference "Bioethics in physi-
Dulak J. New strategies in cell therapy: practical and ethi-
cians profession"
cal problems (lecture)
Cracow, Poland, October 3–4, 2008
115
International Conference Physi-
Maleva MG, Malec P, Prasad MNV, Strzałka K. Effects of
cochemical bases of structural-
heavy metals (Ni, Cu, Cd, Mn) and their cooperative inte-
functional organization in plants
ractions on photosynthetic pigments and chlorophyll fluore-
Ekaterinburg, Russia, October 6–10,
scence parameters in Elodea candensis leaves (poster
2008
presentation by M. Maleva)
Strzałka K. Xanthophyll de-epoxidases – a new group of
enzymes requiring lipid inverted hexagonal phases (lecture)
Strzałka K, Goss R, Latowski D, Grzyb J, Lohr M, Akerlund HE, Wilhelm C, Vieler A. The role of non-bilayer lipids
in the activity of the xanthophyll cycle de-epoxidases: violaxanthin de-epoxidase and diadinoxanthin de-epoxidase
(lecture by K. Strzałka)
9th International Congress of Cell
Dulak J. Heme oxygenase-1 accelerates wound healing
Biology
(lecture)
Seoul, Korea, October 7–10, 2008
7th International Symposium on
Głogowska A, Szewczyk G, Żądło A, Lee H, Wharton T,
Photodynamic Therapy and Pho-
Gali H, Hamblin MR, Sarna T. The effect of melanin,
todiagnosis in Clinical Practice
NADH and histidine on photo-generation of singlet oxygen
Brixen, Italy, October 7–11, 2008
and free radicals by functionalized derivatives of fullerenes
(poster presentation by T. Sarna)
International Congress of Cell Biology
Dulak J. Heme oxygenase-1 accelerates wound healing -
Seoul, Korea, October 8, 2008
(invited lecture)
Russian Academy of Science –
Dubin A. Alternative targets for staphylococcal infection
Polish Academy of Science Sym-
treatment – biochemical study (invited lecture)
posium Perspectives of post-genomic biotechnology
Moscow, Russia, October 15–17, 2008
19th Latin American Microbiology
Kozieł J. Staphylococcus aureus – intracellular pathogen
Congress
(invited lecture)
Quito, Ecuador, October 15–18, 2008
Potempa J. Bacterial proteinases in periodontal disease
(invited lecture)
116
Central European Congress of Li-
Dominik P, Kotlinowski J, Mleczko K, Dulak J, Józko-
fe Sciences EUROBIOTECH 2008
wicz A. Production of retroviral vectors and their applica-
Cracow, Poland, October 17–19,
tions in gene transfer techniques (poster presentation by
2008
J. Kotlinowski)
Drukała J, Puchala J, Chrapusta A, Belowski A, Cieślik K.
Application of in vitro cultured keratinocytes in wound healing (poster presentation by J. Drukała)
Dulak J. Antioxidant genes in endothelial progenitor cells:
significance for therapy (invited lecture)
Józkowicz A. Different vectors for different tasks – new
methods of viral gene transfer (invited lecture)
Gołda S, Jaźwa A, Majka M, Boczkowski J, Józkowicz A,
Dulak J. Overexpression of HO-1 attenuates proliferation,
angiogenesis and metastasis of human lung cancer (oral
presentation by S. Gołda)
Gołda S, Kotlinowski J, Boczkowski J,
Józkowicz A,
Dulak J, HO-1 modulates the expression of genes involved in the inflammatory and angiogenic processes, proliferation, apoptosis and cell adhesion in human lung cancer
cells (poster presentation by S. Gołda)
Gozdecka M, Walczyński J, Skrzypek K, Dubiel M, Zagórska A, Jażwa A, Drukała J, Kieda C, Józkowicz A, Herault Y, Dulak J. Generation of
transgenic mice
overexpressing heme oxygenase-1 in the skin (poster presentation by M. Gozdecka)
Grochot-Przęczek A, Rutkowski A, Kotlinowski J, Szade K, Florczyk U, Milewski K, Wojakowski W, Agarwal A,
Buszman P, Tendera M, Józkowicz A, Dulak J. Isolation,
culturing and propagation of murine and swine bone-marrow
derived endothelial progenitor cells (poster presentation by
A. Grochot-Przęczek)
Grochot-Przęczek A, Kotlinowski J, Łoboda A, Józkowicz A, Dulak J. Effect of heme oxygenase-1 on transcriptome of bone marrow-derived endothelial progenitor cells
in normoxia and hypoxia (poster presentation by A. Grochot-Przęczek)
117
Grochot-Przęczek A, Miś J, Kozakowska M, Kotlinowski J, Dubiel M, Mazan A, Rutkowski A, Kurowski K, Józkowicz A, Dulak J. HO-1 gene transfer with adenoviral
vectors accelerates cutaneous wound healing in db/db diabetic mice (poster presentation by A. Grochot-Przęczek)
Józkowicz A, Dulak J. AAV-mediated VEGF165 and FGF4 gene transfer for the stimulation of reparative processes
in the wounded skin of genetically diabetic mice (oral presentation by A. Jaźwa)
Jaźwa A, Taha HM, Sierpniowska A, Zagorska A, Kucharzewska P, Leja J, Meloni M, Emanueli C, Vahakangas E,
Yla-Herttuala S, Józkowicz A, Dulak J.
AAV-mediated
VEGF165 and FGF-4 gene transfer for the treatment of
hind limb ischemia (poster presentation by A. Jaźwa)
Kotlinowski J, Dominik P, Dubiel M, Kozakowska M,
Waś H, Lemke K, Zebzda A, Majka M, Dulak J, Józkowicz A. Production of cell lines with stable overexpression
of reporter genes and heme oxygenase-1 (poster presentation by J. Kotlinowski)
Kozakowska M, Dulak J, Józkowicz A. Propagation of
adenoviralvectors of first generation (poster presentation
by M. Kozakowska)
Kozakowska M, Marek A, Stefańska A, Mleczko-Sanecka
K, Ostachowicz M, Dulak J, Józkowicz A. Optimization of
titration methods of adenoviral vectors (poster presentation
by M. Kozakowska)
Kozakowska M, Derlacz R, Dulak J, Józkowicz A. Optimization of the methods of isolation and culturing of muscle satellite cells (poster presentation by M. Kozakowska)
Łoboda A, Stachurska A, Kozakowska M, Boesch-Saadatmandi C, Rimbach G, Levonen A-L, Yla-Herttuala S,
Józkowicz A, Dulak J. AdNrf2 and AdHO-1 gene transfer
for amelioration of pro-fibrotic effect of ochratoxin A (poster
presentation by A. Łoboda)
118
Nowakowska N, Bzowska M, Bereta J. Monoclonal scFv
fragments generated using phage display for purposes of
co-crystallization of photosystem II complex (PSII). (poster
presentation by N. Nowakowska)
Rak M, Wybieralska E, Różański I, Masnyk M, Chmielewski M, Łysek R, Chojnacki T, Jankowski W, Ciepichal E,
Swieżewska E, Tekle M, Dallner G, Madeja Z. New cationic polyprenyl derivative proposed as a lipofecting agent
(oral presentation by M. Rak)
Sikora W, Jaźwa A, Kucharzewska P, Józkowicz A, Dulak J. Construction of hypoxia-driven plasmids and AAV
vectors for overexpression of HO-1 and VEGF (poster presentation by A. Jaźwa)
Skrzypek K, Dubiel M, Gozdecka M, Walczyński J, Drukała J, Kieda C, Herault Y, Józkowicz A, Dulak J. Improved wound healing in transgenic mice overexpressing
HO-1 in the skin (oral presentation by K. Skrzypek)
Szade K, Rutkowski A, Grochot-Przęczek A, Józkowicz A, Dulak J. Differentiation of bone-marrow derived
stem cells into neuronal and endothelial cells (poster presentation by K. Szade)
Tertil M, Kozakowska M, Kucharzewska P, Zagórska A,
Józkowicz A, Dulak J. Construction of vectors for shRNAmediated inhibition of heme oxygenase-expression - challenges and solutions (poster presentation by M. Tertil)
Waś H, Sierpniowska A, Sokołowska M, Dominik P,
Skrzypek K, Lackowska B, Ratajska A, Prątnicki A, Mazan A, Dulak J, Józkowicz A. HO-1 delays squamous cell
carcinoma induction and progression (poster presentation
by H. Waś)
Waś H, Cichoń T, Smolarczyk R, Sierpniowska A, Lackowska B, Dominik P, Kotlinowski J, Filip M, Marek A,
Mazur A, Lemke K, Szala S, Dulak J, Józkowicz A. HO-1
expression in host cells affects tumor growth and metastases (oral presentation by H. Waś)
119
14th Biennial Meeting of the So-
Korytowski W, Basova LV, Kernstock RM, Girotti AW.
ciety for Free Radical Research
Bid/Bax-dependent membrane permeabilization enabled
International (14th SFFRI)
by intermembrane transfer of peroxidized cardiolipin: me-
Beijing, China, October 18–22, 2008
chanistic implications for mitochondrion-initiated oxidative
apoptosis (poster presentation by W. Korytowski)
Kozik A, Gołda A. Oxidative inactivation of the human plasma kininogen-kallikrein system (poster presentation by
A. Kozik)
Rąpała-Kozik M, Kowalska E, Ostrowska K, Kozik A. Oxidative stress-induced up-regulation of thiamine-synthesizing, thiamine-activating and thiamine diphosphate-depend
ent enzymes in yeasts and plants (poster presentation by
M. Rąpała-Kozik)
"Philosophycal basis of science
Korzeniewski B. Can an android have a soul? (lecture)
– scientific basis of philosophy"
Ruciane-Nida,
Poland,
October
25–27, 2008
15th Annual Congress of the Eu-
Grochot-Przęczek A, Skrzypek K,
ropean Society of Gene and Cell
R, Miś J, Walczyński J, Dubiel M, Sroczynska P, Koza-
Therapy
kowska M, Kotlinowski J, Rutkowski A, Waś H, Druka-
Brugge, Belgium, November 13–16,
ła J, Derlacz J, Kieda C, Herault Y, Józkowicz A, Dulak
2008
J. Heme oxygenase-1 accelerates cutaneous wound he-
Gozdecka M, Lach
aling in mice (poster presentation by A. Grochot-Przęczek)
Training-Scientific Conference or-
Horwacik I. The use of GD2 ganglioside imitating petides
ganized by Collegium Medicum,
in the immunotheraphy of neuroblastoma. (lecture)
Jagiellonian University Neuroblastoma
Cracow, Poland, November 14, 2008
10th Polish Academic Seminar of
Kołodziejski J. Oncolytic virus – foe or friend? (poster pre-
Biotechnology Students
sentation by J. Kołodziejski)
Gdańsk, Poland, November 21–23,
Skarżyński M, Kotlinowski J. Gene expression in rodent
2008
models of diabetes (poster presentation by M. Skarżyński)
120
Stępniewski J. VSELs – double-edged weapon of our organism. Regeneration and neovascularization (poster presentation by J. Stępniewski)
Surkont J, Grzybowski A, Kędracka-Krok S. Methods of
enrichment and analysis of phosphorylated proteins in proteome studies (poster presentation by J. Surkont and
A. Grzybowski)
EVGN Meeting
Dulak J. Heme oxygenase-1 improves neovascularisation
Bad Hofgastein, Germany, Novem-
and functions of endothelial progenitor cells (lecture)
ber 24–27, 2008
International Conference:
Strzałka K. Violaxanthin and diadinoxanthin de-epoxida-
"Photosynthesis in the Global
ses require non-bilayer lipids for their activity (abstract)
Perspective"
Indore, India, November 27–29, 2008
Conference of the Polish Acade-
Szostek S, Klimek M, Zawilińska B, Kosz-Vnenchak M.
my of Science and Warsaw Uni-
The possibility of herpesviruses contribution in cervical car-
versity
cinogenesis related to HPV (poster/oral presentation by
of
"Vaccines:
Life
Science-SGGW
Advances
in
plant
M. Kosz-Vnenchak)
and microbial biotechnology, in-
Zawilińska B, Krzemień P, Daszkiewicz E, Kopeć J, Kosz-
fection immunity and cancer the-
Vnenchak M. Lymphotropic herpesviruses mixed infec-
rapy.
tions in bone marrow transplant recipients (poster/oral pre-
Celebration
of
the
50th
Anniversary of the First Vaccina-
sentation by M. Kosz-Vnenchak)
tion of a Polish Child Against Polio Using Dr Hilary Koprowski’s
Oral Polio Vaccine"
Warsow, Poland, November 28–29,
2008
The Yearly Conference Sraub’s
Bozkurt O, Komenda J, Itoh S, Komura M, Czer K, Vass I,
Day Biological Research enter,
Malec P, Krumova S, Gombos Z, Kis M. Carotenoid assi-
Hungarian Academy of Sciences
sted assembly and functions of the photosynthetic reaction
Szeged, Hungary, December 3–5,
centers in Synechocystis PCC6803 (poster presentation
2008
by O. Bozkurt)
121
GDRE Polish-French Meeting
Dulak J. Effect of heme oxygenase-1 deficiency and overe-
Paris, France, December 11–12,
xpression on mRNA and microRNA transcriptome in kerati-
2008
nocytes and lung cancer: significance for angiogenesis
and tumor growth (lecture)
9. VISITORS/GUEST LECTURES
Dr. Steven W. Paugh, Virginia Commonwealth University, Richmond, VA, USA, Sphingosine-1-phosphate analogs as potential therapeutic agents, January 11, 2008
Prof. Wolfgang Bilger, Christian-Albrechts Uniwersität zu Kiel, Germany, Interaction of UV-B radiation and low temperature: damage and acclimation, March 13, 2008
Dr. Avigdor Scherz, Weizmann Institute of Sciences, Rehovot, Israel, Vascular targeted PDT –
a new paradigm for prostate and breast cancer, March 14, 2008
Dr. Henning Urlich, University of Sao Paolo, Brazil, APTAMERS as inhibitors of receptor-ligand interactions implicated in disease, May 14, 2008.
Prof. Marek Cieplak, Physics Institute, Academy of Sciences, Warsaw, Determination of genetic networks for metabolic cycles of yeast from microarray data, May 16, 2008
Prof. Justin Mason, Bywaters Centre for Vascular Inflammation, Imperial College, Hammersmith
Hospital, London, UK, Therapeutic induction of heme oxygenase-1 and its potential role in vascular
cytoprotection against complement activation, May 16, 2008
Prof. Zofia Szweykowska-Kulińska, Institute of Moleculr Biolgy and Biotechnology, University of Poznan, Poznan, Micromanaging: specificity of plant microRNA biogenesis, May 20, 2008
Dr. Alex Bunker, Centre for Drug Research, Faculty of Pharmacy, Helsinki University, Helsinki, Finland, In silico drug delivery, May 20, 2008
Dr. Ewa Zuba-Surma, Stem Cell Institute, University of Louisville, USA, Missed pearls - the evidence for the presence of stem cells smaller than erythrocytes in murine adult organs and human specimens, May 27, 2008
Prof. Volodymyr Lushchak, Dept of Biochemistry, Precarpathian National University, Ivano-Frankivsk, Ukraine, Environmental effects on free radical processes in Drosophila and Arabiodopsis, June 3, 2008
Dr. Halina Semchyshyn, Dept of Biochemistry, Precarpathian National University, Ivano-Frankivsk,
Ukraine, Glucose and fructose differently affect baker’s yeast aging, June 3, 2008
Dr. Tomasz Kordula, Virginia Commonwealth University School of Medicine, USA, Tissue-specific
regulation of gene expression in astrocytes, July 3, 2008
Prof. Luis Del Valle, Department of Neuroscience, Temple University, Filadelfia, USA, Activation of
Anti-Apoptotic pathways upon JCV Infection, October 7, 2008
Dr. Marta Miączyńska, Cell Biology Laboratory, International Institute of Molecular and Cell Biology,
Warsaw, Poland, Endocytosis and intracellular signal transfer: two sides of the same medal?, October 14, 2008
Dr. Lizzia Raffaghello, Laboratory of Oncology, G. Gaslini Institute, Genowa, Italy, Advanced course in cancer biology. The course contained the following topics: 1) Neuroblastoma: biological and
clinical features, 2) Immunological mechanisms of neuroblastoma evasion, 3) Chemokines and
chemokine receptors in neuroblastoma progression and metastases, 4) Immunopathogenesis of
opsoclonus-myoclonus syndrome associated with neuroblastoma, 5) Role of extracellular ATP
123
and purinergic receptors in the growth of neuroblastoma, 6) Role of mesenchymal stem cells in
the development of neuroblastoma. The course took place within the framework of Marie Curie
Transfer of Knowledge Functional analysis of new acute phase protein program, October 7–13,
2008
Dr. Małgorzata Lekka, Institute of Nuclear Physics, Kraków – Microscopy of atomic forces in biological research, December 12, 2008

Raport 2008 - Uniwersytet Jagielloński

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