Roslin Institute Newsletter - The Roslin Institute

ROSLIN
REPORTER
Issue 30
Winter 2014
Bill Gates visits
Easter Bush Campus
A
s 2014 comes to its close, the
Roslin reporter is on hand to
summarise the busy second half of
The Roslin Institute’s year.
Inside this issue:
Director’s Message
Page 3
Roslin In The News
Page 4
Other News
Page 12
Recent Publications
Page 36
ill Gates visited the Easter Bush Campus
B
in July to hear about research to improve
the health and welfare of people and farm
animals worldwide.
The
renowned
businessman
and
philanthropist was visiting in his capacity
as co-Chair of the Bill & Melinda Gates
Foundation. The organisation has a strategic
focus on agricultural development and
research to improve farming productivity in a
sustainable way.
Mr Gates was greeted by Vice-Principal
Professor Jonathan Seckl, Professor David
Hume, Director of The Roslin Institute,
Professor David Argyle, Head of the Royal
(Dick) School of Veterinary Studies, Lord
Jamie Lindsay, Chairman of Scotland’s Rural
College (SRUC) and Dr Janet Swaddling,
CEO SRUC.
The party toured The Roslin Institute before
visiting SRUC’s beef research facility on the
outskirts of Edinburgh. The party also visited
the new National Avian Research Facility
at The Roslin Institute. There, scientists
are developing genetic technologies that
are helping to breed chickens that are less
susceptible to diseases, notably those
affecting developing countries.
Among the scientists to highlight their work
were Professor Ivan Morrison and Dr Liam
Morrison of The Roslin Institute. Both are
funded by the Gates Foundation to investigate
new treatments for deadly trypanosome
parasites that affect people and farm animals
in sub-Saharan Africa.
2
SRUC’s Dr Dave Roberts and Dr Mizeck
Chagunda also spoke about their work with
dairy farmers in Malawi. It focuses on the use
of performance recording to increase herd
productivity.
Professor Jonathan Seckl, Vice-Principal
Planning, Resources and Research Policy,
said: “It has been a great pleasure to welcome
Bill Gates to the Easter Bush Campus and
showcase our work as world leaders in the
field of animal bioscience.”
Director’s
Message
W
ith the end of 2014 we find The Roslin
Institute and wider Easter Bush Campus
at the start of so many projects.
With the demolition of the old vet school
canteen and clearance of the ground we now
have the space in which the Easter Bush
Innovation Centre (EBIC) will be built.
The EBIC will be housed as part of a wider
‘Centre Hub’ building that will provide a new
focus for the Easter Bush Campus. In addition
to the EBIC’s business incubator labs, the
building will also house central scientific
resources as well as providing social facilities
including a shop, gym and meeting areas.
The ‘Centre Hub’ building will also house the
Midlothian Science Centre, a teaching lab and
exhibition area that will enable University of
Edinburgh and Easter Bush staff and students
to bring members of the public of all ages
to the campus to experience science of all
disciplines in a variety of different ways.
John
John Mackenzie has joined us at the Easter
Bush Campus where he has taken up the role
of Chief Executive Officer of the EBIC.
Later in this Reporter you’ll read about the
start of the working life of the National Avian
Research Facility’s (NARF) Bumstead Building.
The Bumstead Building is a poultry facility that
will be maintained under specified pathogen free
conditions and provide housing for important
genetic studies in chickens. Alan Hart, who
guided us through the development of these
facilities, has moved on to a more senior position
in Sheffield, but has left us in great shape.
The many ongoing developments are providing
the Easter Bush Campus with the infrastructure
to widen our research capabilities. A prime
example of such opportunities is the Centre in
Tropical Livestock Genetics and Health that The
Roslin Institute and partners from the Royal (Dick)
School of Veterinary Studies and Scotland’s
Rural College have submitted to a major funder.
I will keep you up-to-date with progress of this
centre and with Campus Development in future
issues of the Roslin Reporter.
As Director of The Roslin Institute I was
delighted that The Roslin Institute has been
awarded an Athena SWAN Silver Award. More
about the award later in the Roslin Reporter,
but this is my opportunity to thank the Career
Development Committee, especially Helen
Sang and Cat Eastwood, for all their hard
work in providing new and equal opportunities
for all our staff and students. Roslin was also
at the forefront in the Women in Science and
Engineering (WISE) awards. Jean Manson
was highly-commended for her career
achievements, and we were also short-listed
in the best employer category.
Sam
Still on the theme of starts I am delighted
to welcome Dr Sam Lycett as the latest of
the University of Edinburgh’s Chancellor’s
fellows to join The Roslin Institute. Sam is a
Computational Epidemiologist and has joined
the Division of Infection and Immunity.
In October the BBSRC conducted their
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Midterm Review of The Roslin Institute’s
strategic science programmes. I’d like to thank
Tricia Hart and the programme conveners for
all their work as well as Cat Eastwood, Nicola
Stock and Helen Dundas for presenting our
policies and procedures in a very impressive
way. The review has given us the starting
point for development of the next proposals for
strategic funding, which will be a major focus
of our energies in 2015.
Meanwhile, the outcome of the REF2014
assessment has just been released. The
Royal (Dick) School of Veterinary Studies with
which The Roslin Institute is incorporated was
ranked the number one vet school once again;
the submission to the panel was joint with
Scotland’s Rural College. It is an outstanding
result for us and will hopefully contribute to our
ongoing financial sustainability.
Tricia
The sad news is that Tricia Hart (amongst her
many other skills, the editor of this newsletter
and occasional ghost writer) is leaving us
at the end of this year. Tricia has supported
the development of the Institute is so many
different ways, not least in the massive task
of preparation of the ISPGs and the REF2014
submissions. I certainly owe her a personal
debt for making my job possible for the past 6
years, and I am sure all of The Roslin Institute
wishes her the very best for the future.
As 2014 ends and I escape to the Australian
sun for a few weeks, I wish all the Reporter’s
readers well for the start of 2015.
Roslin in the News
The Roslin Institute is part of ‘Most Powerful’ group
in UK Agricultural and Veterinary Research
A
gricultural and veterinary research at the
University of Edinburgh and Scotland’s
Rural College (SRUC) has been ranked as
most powerful in the UK in the Research
Excellence Framework (REF).
The REF process is an assessment of the
quality of the research being undertaken at
UK Higher Education Institutions (HEIs) and
the impact it has in society. Building on a long
history of collaboration and complementary
activities, SRUC and the University’s Royal
(Dick) School of Veterinary Studies and Roslin
Institute made a joint REF submission.
The collective strength and depth of agricultural
and veterinary research at the University and
SRUC is reflected in its top research power
ranking. Three quarters of the research and
related activity submitted by the University
and SRUC was judged to be “world leading”
(receiving the top REF grading of four star) or
“internationally excellent” (three star).
The impact of group’s research scored
particularly highly. This is an important area
because it demonstrates how the research
undertaken leads to practical benefits for
society – for example in animal health
and welfare, agricultural productivity and
environmental protection. Over 76% of the
Professor David Argyle, Head of the Royal
(Dick) School of Veterinary Studies at the
University of Edinburgh, said: “This outstanding
result is a clear demonstration of the benefits
that University and SRUC research is bringing
to human and animal health, as well as food
and environmental security. Our attainment
of a 4* rating across the board for research
environment cements our position as a worldleading hub for agricultural and veterinary
research. I congratulate the hard work and
dedication of our exceptional staff that has
enabled this achievement.”
impacts described in the submission were
judged to be “outstanding” and over 83% either
“outstanding” or “very considerable”.
The REF panel considered case studies that
demonstrated how research is having an impact
on the UK and worldwide economies. These
included research from The Roslin Institute that
is helping salmon farmers to breed fish that are
more resistant to a deadly virus called infectious
pancreatic necrosis (IPN). In a severe IPN
outbreak, as many as 90% of farmed fish can
be lost. The discovery is estimated be worth
around £26 million per year to the UK salmon
farming industry.
Professor Geoff Simm, SRUC’s Vice Principal
Research said: “This is an excellent result
fulfilling SRUC’s ambition for a top three placing
on research power and further strengthening
SRUC’s ongoing discussions with the University
of Edinburgh about a closer alignment. It is
a fantastic independent endorsement of the
returns to society from investment in agricultural
research. We thank our University partners for
their valuable guidance over several years as
we worked towards our joint REF submission.”
4
The First Exome Sequence Completed in Pigs
P
IC, a division of Genus plc, in collaboration
with The Roslin Institute and Edinburgh
Genomics at the University of Edinburgh, UK,
announced earlier this year that they have
been the first to complete exome sequencing
in pigs. Exome sequencing is a cost-effective
strategy to selectively sequence the most
important parts of DNA and enables faster
genomic progress.
The extensive results of this research,
published in the journal BMC Genomics,
were generated from a targeted set of 96 pigs
representing the known variation in one of
PIC’s leading global proprietary populations
in order to capture as many mutations as
possible.
Exome sequencing has been used in humans
to aid in the diagnosis of Mendelian disorders
(genetic disorders associated with the mutation
of a single gene). PIC will use the information
derived from this research, which also received
funding from the Roslin Foundation and
the Biotechnology and Biological Sciences
Research Council (BBSRC), to achieve more
accurate genomic selection in swine, including
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work to reduce embryonic and/or foetal death
loss in pregnant pigs.
Professor David Hume, Director of The
Roslin Institute and a co-author of the study
said: “The development of a novel genomic
platform is a significant output from the long
term strategic partnership between The Roslin
Institute and Genus. Within the Institute,
we see many applications of this platform in
biomedical research as well as more applied
applications in animal breeding.”
Dr. Jonathan Lightner, Genus Chief Scientific
Officer, congratulated the Edinburgh team
for a well-conducted study achieving
coverage statistics similar to those seen with
commercially available human exome kits.
He added “PIC will continue to invest in and
partner with leading global institutions to
develop the next generation of technologies
that drive faster genomic progress. We are
committed to using these techniques to deliver
the best products to our customers.”
A link to the research paper can be found
at:http://www.biomedcentral.com/14712164/15/550/abstract
Tropical farmers’ plight is focus of
animal research initiative
C
hallenges faced by livestock farmers
in tropical developing countries are the
focus of a new alliance involving researchers
from Scotland and Africa.
The new Centre for Tropical Livestock
Genetics and Health will initially focus on
the use of genetic information to improve the
health and productivity of farmed animals in
tropical climates.
The aim is to develop technologies that will
help farmers in developing countries to identify
the best animals to breed from, so they can
improve the economic value and quality of
their livestock.
Joint teams from Scotland and Africa will
explore the genes that make some animals
more resistant to diseases than others, as well
as those that enable certain breeds to thrive in
warmer, arid conditions.
Researchers will also use genetic techniques
to characterise new diseases that emerge and
to track outbreaks.
The University of Edinburgh and Scotland’s
Rural College (SRUC) have joined forces with
the International Livestock Research Institute
(ILRI) in Kenya to launch the initiative.
The new Centre will have locations in Scotland
and Africa. The Scotland site will be located
on the University of Edinburgh’s Easter Bush
Campus, which includes The Roslin Institute,
The Royal (Dick) School of Veterinary Studies
and Scotland’s Rural College.
Professor David Hume, Director of The
Roslin Institute, said: “With the threat of rising
temperatures due to climate change, the
need for affordable techniques to improve
farming and food security in warmer climates
is becoming a global challenge. We are
delighted to announce this new partnership
to address the issue, which builds on existing,
successful collaborations between our three
organisations.”
Professor Geoff Simm, SRUC VicePrincipal Research, said: “We are proud to
be working in partnership with the University
and ILRI. This is a very significant alliance
because it has the potential to transform our
international efforts to help improve livestock
genetics, enhancing food security but also
reducing the environmental impact of global
livestock production. We also anticipate that
SRUC’s proposed strategic alignment with
the University will significantly strengthen the
potential for the new Centre.”
The Africa site will be located at the
International Livestock Research Institute
(ILRI) in Nairobi, Kenya. It will involve scientists
from both ILRI’s new global livestock genetics
program (LiveGene) and the Biosciences
eastern and central Africa (BecA)-ILRI Hub
and their partners in Africa.
Dr Jimmy Smith, Director General of ILRI
said: “ILRI is delighted to be forming this
new alliance with the eminent University of
Edinburgh’s Roslin Institute and Scotland’s
Rural College. Modern genetic approaches
offer new opportunities to identify livestock
suited to the diverse and demanding conditions
under which African smallholder farmers work.
This new alliance brings together a unique
mix of skills to address these exciting and
important challenges.”
6
£14.5m boost will help
keep Scotland at forefront of bioscience
B
usiness Secretary Vince Cable visited The
Roslin Institute in October to announce a
boost for postgraduate training in Scotland’s
biosciences.
A total investment of £14.5 million will
train postgraduate students in world-class
bioscience that will build on UK strengths
in areas such as agriculture, food security,
industrial biotechnology, bioenergy and
bioscience for health.
Dr Cable made the announcement as he
visited the Institute, where he met researchers
and students.
The investment in the bioscience skills base
will further boost research and innovation in
Scotland and will help to secure the future
of the UK as a global leader in bioscience
research.
Highly skilled researchers are vital for
addressing some of the world’s major
challenges in the 21st century. They fuel
discoveries aimed at solving issues such
as sustainable food production, renewable
energy sources and addressing the health
challenges of an aging population.
A £7.5 million investment from the
Biotechnology & Biological Sciences Research
Council will be matched by £7 million funding
committed by the Universities involved in the
East of Scotland Bioscience Doctoral Training
Partnership (EASTBIO).
EASTBIO is partnership between the
Universities of Aberdeen, Dundee, Edinburgh
and St Andrews. EASTBIO is led by the
University of Edinburgh’s School of Biological
Sciences and includes as associate partners
the Scottish Universities Life Sciences
Alliance (SULSA), James Hutton Institute and
Scotland’s Rural College (SRUC).
Business Secretary Vince Cable said: “The
UK punches far beyond its weight in science
and innovation globally, which is a credit to our
talented scientists and first-class universities.
This new funding will safeguard Britain’s
status as a world leader in life sciences and
agricultural technology.”
1
£
M
5
.
4
7
S
cientists at The Roslin Institute have joined
other dementia experts at the Dementias
Platform UK, which was launched in October
when the ground-breaking, multimillion pound
collaboration between industry and academia,
set up by the Medical Research Council, held
its inaugural conference.
The Dementias Platform UK received a huge
investment through the Clinical Research
Infrastructure (CRII), announced by the
Chancellor of the Exchequer a week before the
launch, bolstering its funding base to £53million.
World leading researchers from universities
across the UK (Cambridge, Cardiff, Edinburgh,
Imperial College, Oxford, Manchester,
Newcastle, Swansea and UCL) and six
companies
(GlaxoSmithKline,
Janssen
Research & Development, AstraZenecaMedImmune, Ixico, SomaLogic and Araclon)
will use state of the art technology to:
• Get a better understanding who is at risk of
developing dementia and why the progression
of the disease varies from person to person
• Explore the anatomy of the disease to help
develop new medicines and enable more
accurate diagnosis
• Look into how existing drugs which are used
to treat other conditions might help to treat
the progression of dementia and improve
symptoms.
Using health and lifestyle information from over two
million people over the age of 50, as well as data
from the lab, the Dementias Platform UK (DPUK)
will focus on improving early detection, treatment
and ultimately the prevention of dementias.
Dementias Platform UK:
A powerhouse for dementia research
The Platform, formally known as the UK
Dementia Research Platform (UKDP), will
create the world’s largest study group for use
in dementia research. It will allow researchers
to examine dementia in a whole new way,
investigating not just what is going wrong in the
brain, but at the brain in the context of the whole
body. The Platform will look at the causes of
dementia across a range of neurodegenerative
conditions, including Alzheimer’s, Parkinson’s
and Motor Neurone Disease.
Professor Jean Manson (above), Head of the
Division of Neurobiology at The Roslin Institute,
said “This is an important initiative for dementia
and it has the potential to have considerable
impact in the diagnosis, treatment and
8
prevention of these diseases. I am extremely
pleased to be engaged with this initiative and
hope to make a significant contribution to the
UKDP.”
Professor Hugh Perry, Chair of the MRC
Neurosciences and Mental Health Board said,
“The Dementias Platform UK is the culmination
of years of dedicated work undertaken by the
Medical Research Council, to identify and
tackle the problems facing dementia research.
Talking to scientists, it became clear that a new
way of researching the disease was needed –
a collaborative approach that took advantage
of the wealth of population studies in the UK. I
think people will look back on the creation of the
Platform as a watershed moment in the study
of dementias, holding the key to accelerating
treatments and ultimately prevention of the
disease.”
Professor John Gallacher, Director of the
Dementias Platform UK said:
‘If we can delay the onset of dementia by just a few
years, we can halve the number of people who die
from the disease. By bringing together the best
scientific minds to discover the causes of these
terrible diseases, we can and will beat them.’
For more information about the DPUK, please visit:
http://www.mrc.ac.uk/research/facilities/
dementias-research-platform/
MRSA bugs linked to livestock
are found in hospitals, study finds
S
ome MRSA bugs in UK hospitals can be
traced back to a type of bacteria found in
farm animals, a study involving scientists at
The Roslin Institute suggests.
According to the study a strain of drugresistant bacteria carried by some livestock
– the MRSA strain Staphylococcus aureus
CC398 – has also been found in patients.
People and animals generally harbour distinct
variants of CC398, which the team say evolved
from the same original bacteria. However,
the CC398 strain found in livestock can be
transmitted to humans, and the study shows
that this has happened on many occasions.
The study provides new evidence that the
livestock-associated CC398 strain could
spread in hospitals.
CC398 from farm animals is resistant to some
common antibiotic drugs, which could make
it harder to treat. The strain’s enhanced drug
resistance in livestock is likely to be the result
of widespread use of antibiotics on farms,
scientists say.
Patients in hospitals and nursing homes
are at increased risk of MRSA infection, but
healthy people in the wider community can
also become infected with some strains.
Scientists at the University of Edinburgh used
a state-of-the-art genetic analysis technique
to study how the CC398 strain evolved. For
the first time, researchers unravelled the full
genetic code of CC398 strains from the UK,
and compared these with published genetic
data on CC398 bugs from humans and
livestock around the world.
They say that CC398 has entered the UK
on several occasions since the mid-1940s,
though the original source of the bacteria
remains unclear.
Lead researcher Dr Melissa Ward, said:
“Our findings emphasise the need for strict
biosecurity practices in the food production
industry, as well as continued surveillance
and infection control of MRSA in hospitals.
Responsible use of antibiotics in healthcare
settings and agriculture is of utmost
importance.”
Professor Ross Fitzgerald of The Roslin
Institute said, “‘The cross-species transmission
of bacteria may lead to new strains with
potential for onward spread in the new host
species.
“Our findings suggest that some livestockassociated MRSA may have the ability to
persist and cause disease in humans in the
hospital setting”.
9
The study, published in the journal Applied
and Environmental Microbiology, was carried
out by the University of Edinburgh’s Centre
for Immunity, Infection and Evolution and
The Roslin Institute, in collaboration with the
Scottish MRSA Reference Laboratory.
The study was funded by the European
Commission Framework Programme 7,
the Biotechnology and Biological Sciences
Research Council, the Wellcome Trust, the
Scottish Universities Life Sciences Alliance,
Pfizer and the Medical Research Council.
A
nimal health experts are joining forces
to combat emerging infectious diseases
that affect farm animals and household pets
across Europe.
They aim to track outbreaks of diseases
such as tuberculosis and influenza, as well
as bacterial infections that can cause food
poisoning if they enter the food chain. The
diseases can have devastating impacts on
farmers’ livelihoods and also pose a threat to
human health.
Vets, scientists and technical specialists
are teaming up to establish a new European
research centre that will be coordinated from a
hub at the Easter Bush Campus in Edinburgh.
Experts hope to develop new diagnostic tools,
vaccines and treatments that help to stop
diseases from spreading.
The Centre of Excellence for Surveillance
Animal experts aim to keep
Europe safe from infection threat
of Emerging Infectious Diseases in Europe
is a collaboration between the Easter Bush
Research Consortium (EBRC), of which
The Roslin Institute is a member, and global
animal health company Zoetis.
It will draw on the expertise of each
consortium member to rapidly respond to
disease outbreaks in animals and help protect
the health and livelihoods of those who raise
and care for them.
Professor David Hume, Director of The Roslin
Institute, added: “Our goal is to detect at a very
early stage new diseases appearing in Europe.
By reaching out to our partners in Africa and
Asia, we hope to identify potential threats, fully
sequence the genetic material of the infectious
agent very quickly and identify routes to
develop diagnostics and therapeutics.”
Michelle Haven, a Senior Vice President and
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vet at Zoetis, said: “Enhanced surveillance to
identify these threats early makes it possible
to speed development of high quality, effective
medicines and vaccines to help control these
diseases. By working together, we can
advance unique solutions to the evolving
and complex threats of emerging infectious
diseases in Europe.”
The Easter Bush Research Consortium brings
together experts from the Royal (Dick) School
of Veterinary Studies and The Roslin Institute
at the University of Edinburgh, Scotland’s
Rural College (SRUC) and the Moredun
Research Institute.
A UK/India partnership
is tackling tick borne
disease of cattle
By Liz Glass
C
ontrolling tick borne diseases (TBD) of
cattle, buffalo and other livestock remains
a world-wide priority. They affect over 80% of
the world’s cattle populations and represent a
significant threat to global food security.
As part of the India-UK collaboration in
Farmed Animal Health and Disease jointly
funded by the Biotechnology and Biological
Sciences Research Council (BBSRC) and
India’s Department of Biotechnology (DBT),
a major new endeavour led by Prof Brian
Shiels at the University of Glasgow will focus
on the “Molecular Epidemiology of Ticks and
Tick-Borne disease, Host Resistance and
Development of Novel Pathogen Vaccines”.
His UK collaborators include Profs Andy Tait
and Rowland Kao, and Dr William Weir (all
University of Glasgow) and Prof Liz Glass
of The Roslin Institute at the University of
Edinburgh. They have teamed up with Indian
colleagues Drs Sunil Kolte, Nitin Kurkure
and Suresh Jadhao of the Department of
Parasitology, Nagpur Veterinary College,
Maharashtra together with Prof G Ponnudurai
Veterinary College and Research Institute,
Namakkal, and Profs TJ Harikrishnan and
Bhaskaran Ravi Latha, Madras Veterinary
College, Chennai, Tamil Nadu Veterinary and
Animal Sciences University. All participants
have long standing expertise in aspects of
ticks and TBD of livestock.
Control of TBD mainly relies on chemicals
such as acaricides to kill tick vectors and/or
drugs that kill the parasites, or live vaccines.
These all have major drawbacks including
development of resistance to chemicals
and difficulties of preparing and delivering
live vaccines which are often only partially
effective. Young livestock are particularly
susceptible to TBD. However the carrier
state in older animals very likely causes major
production losses, but this has not been well
quantified in countries such as India.
The inaugural meeting took place at the
Department of Parasitology, Nagpur Veterinary
College from 26th – 29th November 2014 where
most of the participants met for the first time. The
UK visitors were treated very hospitably by the
enthusiastic Indian hosts. They were welcomed
by the Vice Chancellor, Professor Misra,
followed by an invitation to Prof Shiels to light a
candle as part of a traditional Indian ceremony
of welcoming and all of the participants were
presented with flowers. Over the course of the
meeting the parties exchanged knowledge and
ideas to formulate plans to tackle TBD in India.
India has many distinct breeds as well as
“non-discript” (i.e. not described) Bos indicus
cattle and buffalo, but most are not well defined
genetically and little has been documented
about their resistance to infectious diseases.
The UK team had tours of the Institute and
the local farm where they saw Sahiwal/Jersey
crosses (susceptible to ticks and TBD) and
distinctive local breeds, such as the Gaolao, a
dual purpose breed with a “coffin shaped skull”
(may be more resistant) as well as buffalo
breeds.
Host diversity and resistance will be explored
using micro-satellite markers as well as
experimental challenge of cattle breeds with T.
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annulata, a tropical protozoan. Their clinical
and haematological responses as well as
gene expression in blood (RNA-seq) will be
compared with the aim of identifying biomarkers
of resistance. Earlier studies by Prof Liz Glass
has shown that purebred Sahiwals were much
more resistant to T. annulata, compared to the
more familiar Holstein-Friesian found in the
UK and elsewhere.
The collaborators were interviewed and
appeared in the local paper, the Hitavada. The
UK group were taken out for dinner feasting
on goat curry and Indian beer – it was cold
enough in the evening for braziers, though the
hardy Scots did not require their jackets! They
also visited the beautiful Tadoba-Andhari
Tiger Reserve where they were lucky enough
to see a tiger! On their trip they also saw lots
of cattle and buffalo at road edges. They were
also invited to the Central India Institute of
Medical Sciences which has a joint research
project with the Nagpur Veterinary College
on zoonoses including Mycobacterium bovis.
India has a fantastic diversity of breeds with
potential disease resistance traits awaiting
discovery which could lead to targeted marker
assisted selection in the future, whereby TBD
resistance loci could selected along with loci
controlling higher milk yield, resulting in higher
performing cattle in local Indian environments.
Other News
Kim P
Summers
elected to
Society of
Biology
rofessor Kim Summers from The Roslin
Institute’s Division of Genetics and
Genomics has become the latest senior Roslin
researcher to be elected as a Fellow of the
Society of Biology.
The Society of Biology describes itself as
“a single unified voice for biology: advising
Government and influencing policy, advancing
education and professional development and
engaging and encouraging public interest in
the life sciences.”
Elected fellows are those who have made a
prominent contribution to the advancement of
the biological sciences in many ways including
research or training. Several other Roslin
Institute group leaders are already Fellows
of the Society, highlighting the position of the
Institute in the forefront of biology in the UK.
Kim’s research interest is the molecular basis
of disease, both in humans and animals.
Since coming to the Institute in 2008 she has
made links with the clinical staff at R(D)SVS to
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establish a number of projects in the area of
canine genetic disease. The close relationship
of such diseases in dogs to similar diseases
in humans means that Kim’s research spans
the human and veterinary medicine fields and
is an excellent example of the “One Health”
approach.
Also pursuing the One Health agenda, Kim
established the MSc in Animal Biosciences
in 2011, aiming to train future researchers in
aspects of research for and with animals. The
programme has now graduated 22 students,
some of whom are currently undertaking PhD
studies at the Institute or elsewhere while
others are working in industry and government.
Kim said of the Fellowship, “I’m very pleased
to join the other Roslin Institute Fellows in the
Society of Biology. Thank you to those who
nominated me – I appreciate your support and
encouragement and the opportunities to do
fun science that working at The Roslin Institute
has given me.”
Lord de Mauley visits
esearch to improve the health and welfare
of animals, the livestock industry and food
security were discussed when Lord de Mauley,
Parliamentary Under Secretary of State for
natural environment and science, visited the
University of Edinburgh’s Easter Bush Campus.
Lord de Mauley spoke to researchers from
The Roslin Institute, the Royal (Dick) School of
Veterinary Studies (R(D)SVS) and Scotland’s
Rural College (SRUC) who are based at the
Easter Bush Campus.
During the visit, Lord de Mauley highlighted
the role of research in helping to reach the goal
of the UK Government’s Agri-Tech Strategy
to make the UK a world leader in agricultural
technology, innovation and sustainability.
During the visit Lord de Mauley learned about
the opportunities UK organisations such as
The Roslin Institute and SRUC can play in
addressing key issues such as global Food
Security. He was provided with an overview
of one of The Roslin Institute’s key assets,
the National Avian Research Facility, which
is based at the Easter Bush Campus. Aims
for the facility include addressing the need for
improved sustainability in poultry production
in light of an increasing global population,
developing vaccines against infections and
benefiting human health through reducing foodborne diseases.
Lord de Mauley, Minister for the Natural
Environment, said, “The Roslin Institute and
SRUC play vital roles in the UK Government’s
Agri-Tech Strategy. I was fascinated to see
funding being used to develop technology
Easter Bush Campus
R
to feed cattle more efficiently while reducing
greenhouse gas emissions, which will
greatly benefit farmers, consumers and the
environment. The Roslin Institute is the UK’s
leading farm animal research institution and
SRUC is a brilliant model for disseminating new
technology to farmers across Britain and the
world.”
Professor Hume said of the visit, “It is a
pleasure to discuss with Lord de Mauley the
opportunities for world leading UK agricultural
research to develop at Easter Bush Campus.”
The Roslin Institute to benefit from
new Sequence-Based Genotyping
K
eygene N.V. an Ag Biotech company
announced today that it has entered into
a licence agreement with the University of
Edinburgh in the field of Sequence-Based
Genotyping (SBG).
Under the agreement, the University of
Edinburgh obtains a non-exclusive licence for
the use and application for research purposes
of KeyGene’s patented SBG technology
including RAD-Seq. The SBG patents protect
methods which allow discovery and scoring of
genetic markers without genome sequence
information in an extremely cost-effective way.
Michiel van Eijk, CSO of KeyGene, said, “We
are very pleased with licensing the University
of Edinburgh in this important research field
of next-generation sequencing based genetic
marker analysis. The ability to perform
genetic marker discovery and genotyping
simultaneously finds widespread use in a
huge range of species”.
The license will enable ARK-Genomics, a
national capability based at The Roslin Institute
and strategically funded by the Biotechnology
and Biological Sciences Research Council
(BBSRC), to deliver genotyping-by-sequence
projects to the farm animal genomics
community. The ARK-Genomics national
capability forms part of Edinburgh Genomics,
a leading academic next generation genomics
facility based at the University of Edinburgh.
Keygene’s SBG technology will be utilized at
The Roslin Institute to investigate the genetic
basis of important traits in animal health and
food security, such as the genetic basis of
disease resistance and key production traits.
For more about this story, please visit:
http://www.keygene.com/keygene-licencessequenced-bases-genotyping-to-universityedinburgh/
13
New Research Partnership
to Advance Broiler Genetics
A
three-year research agreement between
Cobb-Vantress, Inc., a global industry
leader in poultry genetics, and The Roslin
Institute, at the University of Edinburgh,
will facilitate collaboration on avian disease
resistance, genome analysis and genome
preservation.
Cobb is putting almost $1 million into avian
research programs at The Roslin Institute
to identify innovative ways to improve
avian health as well as developing unique
technologies to understand and preserve the
current and heritage poultry genomes.
The investment creates a strategic
partnership between Cobb and The Roslin
Institute which leverages each world class
entity’s strengths. Mitch Abrahamsen, Cobb
vice president of research and development,
stated: “This research partnership provides
a wonderful opportunity for Cobb to continue
a close collaborative relationship with The
Roslin Institute and their new National Avian
Research Facility (NARF).
“The continued financial investments by The
Roslin Institute in people and infrastructure
demonstrate their commitment to making
significant contributions toward improving
poultry health and capitalizing on the
opportunities afforded by the ever expanding
understanding of the chicken genome.”
Professor David Hume, director of The Roslin
Institute, said of the new agreement: “The joint
partnership with Cobb is an excellent example
of the kind of industrial interactions that
allow The Roslin Institute’s research to drive
sustainable improvements in animal health
and livestock productivity.
“I am delighted to be able to formalize the
relationship we have with Cobb and capitalize
on a number of key opportunities that we will
be pursuing under the agreement.”
One of the applications of this joint partnership
is an effort to develop new technology enabling
pedigree or heritage lines to be maintained
without the need to physically maintain the
bird stock. In addition, several projects will
investigate DNA markers in the genome,
targeting some of the more difficult to select
for traits such as avian immunity, disease
tolerance and disease resistance.
“These are exciting new areas which we hope
will lead to major breakthroughs in avian
health and preservation.” said Dr Christine
Daugherty, chief technology officer of Cobb.
“Cobb has an extensive gene pool and to be
able to better understand the poultry genome
will be critical to meeting future demands for
poultry products. We’re always striving to
breed more robust chickens that will withstand
disease and environmental challenges. We’re
looking for birds with greater immunity to
diseases or with the ability to tolerate disease
without affecting their performance.”
The collaboration will support research
by graduate students and is for an initial
three years, with potential for renewal.
The agreement with The Roslin Institute,
which receives strategic funding from the
Biotechnology and Biological Sciences
Research Council, is one of more than
30 research projects that Cobb has been
supporting in 18 different universities across
the globe over the past five years.
M
1
$
14
Roslin Student
shortlisted in image
competition
D
eclan King, a PhD student from The
Roslin Institute, had his image
shortlisted in the BBSRC’s Images with
Impact competition.
The competition sought images that
represented how life sciences are
changing the world, in areas such
as: food, farming, bioenergy,
biotech, industry and health.
The shortlist was selected by
an esteemed panel of judges.
The public then had their say
and voted for the category
winners and runners up.
Great Britain has always
been the home of bioscience
discovery. Penicillin, the DNA double
helix and The Roslin Institute’s very own sheep
called ‘Dolly’ were all born of UK research, but
never before has bioscience moved at such
a pace.
With this competition the BBSRC aimed
to capture the exciting developments and
challenges happening in bioscience today,
with images from the Great British public, its
students and its researchers.
Declan’s image was shortlisted in the “Images
from a student” category and is a microscopy
image of the complex networks established
between nerve cells grown in the laboratory.
Sadly Declan’s image was not one of the final
three category winners that went on to be
shown at the Great British Bioscience Festival
in London in November, but we thought it was
the best!.
Dec with two potential scientists of the future at
the recent Easter Bush Doors Open Day
15
T
here is much progress and change to report
in this issue of the Roslin Reporter as the
National Avian Research Facility (NARF)
continues to move forward to provide The
Roslin Institute and further afield with the most
advanced facilities to perform avian research.
Change brings exciting opportunities for all
willing to embrace the possibilities and it is
something that as scientists we should grasp
to provide the opportunities to progress.
The Greenwood Building
After 40 years of first-class service Margaret
Murray decided to hatch her last chick and
retire. Margaret’s last day was on the 3rd
October 2014 and as a group we all headed
out to the local Italian restaurant, Cibo. It was
a fun lunch with the waiters making a fuss
of Margaret which was well deserved. We
all wish Margaret well and a long and happy
retirement.
NARF News
By Alan Hart (NARF Coordinator)
In August we had two new starts in the
Greenwood and both Mark and Richard have
settled in very well. We are awaiting Margaret’s
replacement with the new incumbent in place
by late November.
The Bumstead Building
is now fully operational with the keys handed
to Kim and her team early in November. Willie
has moved from The Greenwood Building
to join Kim and two new members of staff
Tomasz and Graham. All have been getting to
grips with the facility and the procedures that
are required to maintain the integrity of the
building. If you walk by Willie and the guys the
sweet scent of lavender, or rose petals will be
apparent from the numerous showers that are
taken to enter their place of work. This is just
the sweet smell of success!
The first eggs arrived just days after Kim
got the keys and it was commendable to all
involved in this build that we were able to open
on time. Many thanks to all the guys involved
in the construction, Miller Construction,
Shepherd Engineering and others companies.
With special thanks to the E&B project lead
and others from the E&B team.
As this Reporter was going to print the first
chicks hatched in the Bumstead Building so
congratulations to Kim and the Bumstead
team for hitting the ground chirping!
16
NARF changes
Dave Burt (above) has taking over as acting
director for NARF and he’ll be your first port of
call for all matters relating to NARF; enquires
through [email protected]. As I have
intimated earlier Kim Bernard is your contact
for all matters relating to The Bumstead
Building and SPF eggs. Kim will be happy
to receive enquires through the spf.eggs@
roslin.ed.ac.uk account. Adrian Sherman will
continue to be your contact for matters relating
to avian work at The Greenwood Building and
transgenic chicken work, enquiries through
[email protected] account.
As for myself I have moved on to pastures
new to take up my new post at the University
of Sheffield. Exciting times are ahead for
both myself and NARF and I look forward
to watching the success of NARF as it puts
chicken at the forefront of scientific discovery.
Millipore Prize for Laura
P
ostdoctoral researcher at The Roslin
Institute, Dr Laura McCulloch, has been
named as the winner of a Merck Millipore
competition to win the company’s new
Luminex MAGPIX® System, 40-072.
Merck Millipore ran the competition asking
entrants to describe how they would use the
MAGPIX® System in their own research.
The MAGPIX® System, 40-072 provides
rapid, accurate biomarker quantitation in
a variety of sample matrices. In essence it
provides a means by which researchers can
study how protein expression differs between
samples.
Laura said of the prize, “I was delighted to win
the MAGPIX® System and can’t wait to use
it in my research. This is going to be a great
addition to The Roslin Institute’s technical
capacity and there are a lot of researchers
here that are already planning how they can
use the MAGPIX® System in their projects.”
Laura’s proposal and entry to the competition
described a study aimed at assessing blood
biomarkers of immunosuppression in mice,
following a stroke, which could then be
correlated in human blood samples.
Dr Steven Suchyta, Product Manager at
Merck Millipore said of the winning entry, “Of
over 150 entries from around the world, Laura
won the prize because her proposal is the
most novel and translatable.
“Millipore welcomes all opportunities to work
with cutting edge research organisations such
as The Roslin Institute and this is a great
example of such interactions.”
The MAGPIX® System was delivered to The
Roslin Institute in June from Merck Millipore
who provided Laura with some £10,000 of
multiplex kits to get her started.
Dr Suchyta said, “I am pleased to say that
Merck Millipore will be running a Magpix grant
program again this year and I look forward to
receiving more proposals as imaginative and
innovative as Laura’s.
For more information about the MAGPIX®
System, 40-072 please see http://www.
millipore.com/catalogue/item/40-072
Kits for the MAGPIX® System are available
17
for many protein markers across multiple
species please see http://goo.gl/sijRXn
Merck Millipore representatives will be holding
a seminar at The Roslin institute soon with
information on how the MAGPIX® System
may be useful to researchers across multiple
fields of research in The Roslin Institute,
R(D)SVS and SRUC and future grant
programs available from Merck Millipore.
Laura’s research continues to be successful,
winning poster prizes at the Edinburgh
Infectious Diseases annual symposium in May
and the Inflammation and Disease meeting
held by the British Society for Immunology
Inflammation Affinity group in Manchester in
September. Laura has also recently been
awarded a $1,500 scholarship from the
American National Institute of Neurological
Disorders and Stroke (NINDS) to attend a
Keystone meeting “Neuroinflammation in
diseases of the CNS” in New Mexico.
S
eptember saw the The Roslin Institute
hold its biannual celebration of staff
achievement, the “Recognising Excellence”
Awards.
The Roslin Institute’s HR Manager, Cat
Eastwood, explained, “We feel that it is
incredibly important to recognise our staff for
the outstanding work they undertake in pursuit
of The Roslin Institute’s research goals.
The fact that we had so many very strong
nominations from both the scientific and the
operational sectors of the Institute is indicative
of how highly the staff are regarded.”
The Institute’s Impact Committee,
chaired by Professor Helen Sang, made
recommendations for the award recipients
based on the nominations received from staff
and students from across the Institute. The
recommendations then went to the Institute’s
Science Management Group for final approval.
On presenting the awards, Professor David
Hume, Director of The Roslin Institute, said,
“I am so proud of what the individual staff
and students achieve at The Roslin Institute
and their combined force is what makes the
Institute so strong. These awards recognise
those who have really gone above and beyond
in their work, but I know there are many more
who would also be worthy winners.”
Roslin Recognises
Excellence in Staff Awards
The full list of winners is:
Outstanding Science Team – Team Sheep led
by Iseabail Farquhar and Emily Clark
Excellent Scientific Support
– Rhona Muirhead
Outstanding Operational Support – Liz Brown
Outstanding Operational Support (Team)
– Cleaning Team
KEC – John Hickey
PE – Katie Nightingale
Inspiring Supervisor/Mentor Award
– Steve Bishop
Emerging Researcher (PhD Student)
– Natasha Whenam
Emerging Research (Post-doc award)
– Louise Stephen
Outstanding Researcher – Barry McColl
Special Recognition – Bob Fleming
18
Small World : Huge Prize
D
r Nils Lindström has come 16th in the
Nikon Small World Competition. His
amazing image, taken while Nils was a
postdoc at The Roslin Institute, shows three
transgenic kidneys cultured together, showing
colliding branching collecting duct systems.
Nils, who is now based at the Edinburgh
Cancer Research Centre, said of the placing,
“I am very happy with this outcome because it
is a very competitive section and I was the top
UK-based image.”
To see all the winning images and to find
out more about the competition, please visit:
http://www.nikonsmallworld.com/galleries/
photo/2014-photomicrography-competition
Nils
Festival
Midlothian Science
F
rom 4-19 October, science-themed events
were happening all over Midlothian as
part of the third annual Midlothian Science
Festival. The Roslin Institute is a major partner
of the festival and staff and students from the
Institute were involved in six events this year
in addition to the Easter Bush Campus Open
Day, including a genetics talk for students at
Beeslack High School and ‘Farm Detectives’
workshop for P4 and P5 pupils at Roslin
Primary School and a science cycle ride with
the Midlothian Ranger Service and a family
tour of Langhill Dairy Farm. All the events
were extremely well received, with participants
really appreciating the chance to find out
more about the research happening on their
doorsteps.
The Midlothian Science Festival is a volunteerrun festival dedicated to sharing science with
communities in Midlothian. Most of the events
are based in community venues and as many
as possible are offered free of charge. For
more information about the festival visit www.
midlothiansciencefestival.com
19
Easter Bush Campus Open Day
T
he Easter Bush Campus hosted its annual
Public Open Day at The Roslin Institute
Building and Veterinary Teaching Building on
4 October, welcoming around 400 members of
the public onto campus for the afternoon.
The 2014 event had the privilege to be the
opening event of this year’s Midlothian Science
Festival and it featured a programme packed
with hands-on activities, science shows, talks
and building tours in both buildings.
The Roslin Institute Building had over
100 volunteers from The Roslin Institute
and Scotland’s Rural College running 25
activities across three floors. Visitors had the
opportunity to see, amongst other things, the
Institute’s BBSRC Great British Bioscience
Festival exhibit “Flu Fighters” as well as
finding out about farming of the future, how
genes determine coat colour in Labradors and
a chance to meet the infamous Dr Poo!
Thanks to support from the Midlothian
Science Festival, The Roslin Institute was also
delighted to be able to welcome Simon Watt
with his Superhero Genetics Show, which was
a big hit with visitors.
As always, the visitor feedback was
overwhelmingly
positive,
with
many
compliments about our engaging, friendly staff
and student volunteers who made the science
interesting and accessible to everyone. The
only complaint was that we should have been
open for longer to allow time to see it all!
20
E
Ethics
Prize Winners
arlier this year, Dr Doug Vernimmen
repeated his course on Ethics about what
scientific issues to expect in the future and
how we would solve these.
Science has dramatically progressed since
the full sequencing of the human genome a
decade ago but also the research on stem
cells. Stem cells can be differentiated in any
cell type, giving new horizons for cell therapy
but also in livestock. Together with the high
throughput sequencing techniques, the secret
of the genome can now be uncovered, which
implies several ethical issues.
The course used well known films to prompt
discussion groups that were followed by
students writing an essay of 2-4 pages. The
format was presented as a competition within
the Institute with two winners receiving a prize.
Congratulations to Anuj and Selene.
N
Winner Anuj Sehgal with his first
prize voucher for his essay “Until
death do us apart”.
Hostess Kirsty Ireland presents
Anuj with a bottle of wine.
Runner up Selene Jarrett receives
her prize for her essay “First comes
love” from Doug watched over by
the other competition entrants.
The bacterially inclined visit Firbush
ovember is not traditionally the time of
year people think about doing too many
outdoor activities, but we’re a hardy bunch in
infection and immunity. So, November 17th20th saw about 27 members of the bacterialfocused research groups from infection and
immunity head off to the University-owned
Firbush outdoor centre for a two-day retreat.
After arriving Monday around mid-day, we
had our first activity-a friendly competition of
orienteering, which of course doubles as a
team-building exercise! (Orienteering, mapreading, bumbling around in the bushes up
and down hills to find a little punch to mark
your scorecard.)
After recovering with a bit of a hot drink, we
had the first round of talks from the students
and post-docs before dinner. Post dinner
games and a bit of networking were the order
of the evening before falling (well, for me
anyway!) into bed for some quality sleep.
Tuesday morning saw two more sessions of
talks, interrupted by a further activity period
for a change of pace. Overall, it was a great
opportunity to hear what our colleagues are
By Robin Cassidy-Cain
By Robin Cassady-Cain
20
doing and to get feedback on direction of
research or offers of help with techniques and
suggestions for experiments.
It was also interesting to see the commonalities
and diversity of research happening across
the groups from the more clinically-related
21
research to very basic research, and to get to
know some of the members a bit better.
It was a great experience, I think everyone
got something out of it, and I look forward
(hopefully) to more of them in the future!
Roslin Institute ‘Flu Fighters’ at the
Great British Bioscience Festival
I
n mid-November a team of virology
researchers from The Roslin Institute headed
to a marquee in Bethnal Green, East London
to bring the best of British Bioscience to the
general public. The Great British Bioscience
Festival was the culmination of a year-long
programme of activities to mark the 20th
anniversary of the Biotechnology and Biological
Sciences Research Council (BBSRC), enabling
members of the public to explore the fascinating
world of biology through interactive science
exhibits with real scientists.
The Roslin Institute exhibit ‘Flu Fighters’ was
developed alongside colleagues from The
Pirbright Institute and focused on the many
ways in which our researchers are fighting
influenza, a major global threat to both human
and animal health. It showcases current
research including creating flu-resistant poultry,
novel approaches to vaccines and diagnostic
tests and host/virus genetics.
Visitors to the exhibit had the opportunity to get
hands-on and run a diagnostic test on a (very
realistic model!) chicken to discover whether
it was infected with flu, create their own flu
virus strain and discover more about the virus,
including its huge range of host species and
details of the virus life cycle. The exhibit also
demonstrated how flu transmits from animals
to humans and highlighted the challenges of
preventing large-scale outbreaks.
The Great British Bioscience Festival, a
partnership between the BBSRC and LND
Science Festival, was a huge success,
attracting over 6,700 visitors across three days.
On the Flu Fighters stand over 1,000 diagnostic
tests were performed, 750 flu logo bugs and
hundreds of Flu Fighters stickers were given
away and there were countless conversations
with visitors of all ages about flu research at
The Roslin Institute.
Nicola Stock, Public Engagement Officer at
The Roslin Institute, said “The Great British
Bioscience Festival was a great opportunity for
the public to meet scientists, learn about the
amazing research happening around the UK
and find out about the impact that it could have
22
on their life. We were really impressed with the
interest and enthusiasm of the visitors, many
of whom came back for a second visit as there
was so much to see.”
Flu Fighters will be appearing at a range of
events in 2015, including ‘Discover Science’ at
the National Museum of Scotland, part of the
Edinburgh International Science Festival, from
14-18 April.
–Work
Science
Insights
his July The Roslin Institute hosted
T
‘Science Insights’ a brand new work
experience programme for High School
students interested in a career in biological and
biomedical science. Created in collaboration
with colleagues at the Institute of Genetics and
Molecular Medicine (IGMM) and the University
of Edinburgh’s Widening Participation team,
Science Insights provided sixteen S5 students
from across the region with unique access
to researchers and facilities at The Roslin
Institute and IGMM.
The students, who gave up a week of their
summer holiday to attend the programme,
had a packed timetable for the week which
included four lab placements with IGMM and
Roslin scientists, tours of facilities including
Dryden Farm and IGMM’s Bioimaging Suite
and talks on current research, scientific ethics
and careers in science. The two days at The
Roslin Institute involved over twenty PhD
students and members of staff, who kindly
Experience
with a
Difference
gave up their time to inspire these potential
future scientists.
Feedback from the programme was excellent,
with students reporting that they found the
week useful and inspiring and many of them
suggesting that the programme should have
been two weeks long! Science Insights will
be back again in 2015 and more information
about the programme is available at www.
scienceinsights.ed.ac.uk
Pip wins Royal College of Pathology
oslin Institute Career Track Fellow, Dr
Pip Beard, has been awarded the Royal
College of Pathologists’ Specialty Research
Medal for 2014 for her paper entitled “TRAF2
Facilitates Vaccinia Virus Replication by
Promoting Rapid Virus Entry”.
The work was carried out in Pip’s laboratory,
in particular by postdoctoral scientist Ismar
Haga. It describes the role of the cellular
protein TRAF2 in allowing Vaccinia virus to
enter a cell.
Ismar and Pip showed that when TRAF2 was
removed or suppressed the virus was unable
to enter efficiently. The crucial experiment
in the work involved visualising individual
fluorescently labelled viruses using high
powered microscopes in The Roslin Institute’s
bioimaging suite.
The Royal College of Pathologists’ Specialty
Research Medals are awarded annually for
outstanding research work undertaken by
pathologists or scientists in training. Pip will
be traveling to London to receive the medal in
March 2015.
23
Award
R
Public Engagement
and Science Communication
Roundup
By Nicola Stock
(Public Engagement Officer)
2
014 has been a busy year for public
engagement and science communication
at The Roslin Institute, with well over eighty
different activities happening through the year.
These ranged from participation in external
events such as the Royal Highland Show and
the Edinburgh and Midlothian Science festivals,
public lectures and lab placements, to work with
schools both on and off campus, press articles
and appearances on television and radio.
This year has seen The Roslin Institute
working with some new partners here in
Edinburgh, including closer work with the
National Museum of Scotland and a new
relationship with the Edinburgh branch of
the British Science Association (BSA). The
Institute contributed to three of the National
Museum of Scotland’s popular ‘Museum
Lates’ events in 2014 and we were invited to
launch the BSA’s new ‘SciScreen’ programme
of film screenings with accompanying
scientific talks and discussion. We also had
our first experience of the Edinburgh Festival
Fringe, with a show entitled “We’d Eat GM
Meat – Would You?” as part of the Cabaret
of Dangerous Ideas, performed in a yurt on St
Andrew’s Square!
The Institute’s work with schools continues to
grow and 2014 has seen eleven institute visits
by groups from high schools across the region.
Staff and students have also gone out to
schools, participating in eighteen science and
Coaching for Success Pip Beard
ix Roslin Institute female scientists at professional goals.
S
various stages of their career were recently sI especially valued the time to initially reflect on
sponsored to participate in the ‘Coaching for strengths and weaknesses, and later to reflect
careers events, several as part of the STEM
Ambassadors scheme. In addition to our new
‘Science Insights’ work placement scheme,
Institute staff and students also hosted four
high school students on Nuffield Research
Placements for 4-6 weeks during the summer,
which culminated in a celebration event at the
Royal College of Physicians in Edinburgh.
None of this would be possible without the
time and hard work of our staff and student
volunteers, so a huge thank you goes out to
everyone who has been involved this year.
Look out for more exciting public engagement
events in 2015!
By
Success’ programme run by Equate Scotland.
Professional career coaching is a process
that helps coachees understand more about
their work role and the issues they need to
address to realise their potential and ultimately
increase their job satisfaction. A coach can
help you learn more about yourself and your
abilities, and help you formulate your own
solutions to problems - the coach will not tell
you what to do, but will help you think through
the options.
Equate’s Coaching for Success programme
is specifically aimed at SET (Science,
Engineering and Technology) women
who would like to progress in their career,
including those who are looking to return to
work after a career break. The programme
at The Roslin Institute consisted of five hour
long meetings with the coach, plus email and
phone contact between meetings. Coaches
helped participants set career goals, develop
managerial skills, build confidence, and enrich
professional relationships.
Participant’s comments:
sI found the experience to be exceptionally
valuable and positive, feeding into aspects of
both my work and home life.
sHaving recently returned to a research role
after a break due to family responsibilities,
coaching helped to build my confidence,
and gave me the opportunity to evaluate
my priorities and longer term personal and
on the impact of implementing the new tools and
strategies.
sI particularly appreciated being able to talk
through the issues facing me with someone
external who has an independent perspective.
sI found coaching to be an amazingly powerful
technique for highlighting my strengths, and
identifying my priorities and goals
sThe coaching sessions allowed me to
distinguish between unnecessary pressure that
I was putting on myself from real pressures that
needed to be resolved
sI was able to focus and prioritise my tasks better
and reduced the amount of worry and stress over
career progression
sI would recommend professional coaching
to anyone facing challenges or change in their
career – it provides focus and self-assurance
Established in 2006, Equate Scotland
is Scotland’s expert in gender equality in
Science, Engineering and Technology (SET).
Their Coaching for Success programme was
instigated in response to a considerable body
of evidence which shows that women can
encounter structural barriers to their progression
in the SET professions - the “glass ceiling”. There
is also evidence which points to the ‘sticky floors’
that can prevent women from making the most of
their skills, knowledge and abilities. For example:
Many more women train in SET subjects than
move into the SET workforce. In Scotland, 27%
of women graduates in SET work in the sector
24
they qualified in compared with 52% of male
graduates.
There is an under-representation of women in
the highest academic ranks and in decisionmaking positions. For the past 20 years the
bioscience undergraduate population in
Scotland has been predominantly female
(>50%), however the proportion of female
senior lecturers in 2008-2009 was 30% and
for female professors just 15%.
In other words there are internal barriers
which can hold women back in both SET
industry and academia. In Scotland, the loss
of female scientists (the so called “leaky
pipeline”) results in a loss of potential income
to the Scottish economy estimated at as much
as £170 million per annum.
Any Roslin Institute scientist who is interested
in learning more about the coaching experience
and what it involves should contact Pip Beard.
For information about future Coaching for
Success programmes contact Easter Bush
HR ([email protected]).
Pip
Career Development Committee: “Awards Season!”
T
he Roslin Institute Career development
Committee has been working towards
submitting an Athena SWAN silver award
over the last 3 years. Athena SWAN is a UK
government-backed charter for women in
science aimed at advancing the representation
of women in science, technology, engineering,
medicine and maths (STEMM) http://www.
athenaswan.org.uk/content/athena-swan.
In the application submitted in April we had
to present data, for example on the proportion
of women at different levels at the Institute,
and describe actions that we have taken
to support career development that will
encourage women to progress their careers.
These include our Grant Writing Course,
Mentoring Scheme for postdocs, Fellowship
Support Group and grants for childcare costs
for parents attending conferences. The full
application can be read at http://www.roslin.
ed.ac.uk/about-roslin/athena-swan/
We were delighted to be successful in our
application and Helen Sang (research leader
at The Roslin Institute) and Cat Eastwood (HR
Manager) went to the Athena SWAN awards
event hosted by Cambridge University in
November.
Cambridge University received a silver
award (organisation award), based on
a big commitment from the university to
make changes to systems, for example
promotions and appointments, to ensure
that they are fair, transparent and recognise
all academic activities, including research,
teaching and community contributions e.g.
public engagement. They have produced an
interesting book about perceptions of “The
meaning of success” by consulting female
staff – this book is online http://issuu.com/uni_
cambridge/docs/the_meaning_of_success_
final_revise.
The Athena SWAN awards require major
commitment to change that must be sustained:
83 organisations/departments applied in
April, of which 69% were successful with 63
receiving bronze awards and 20 silver, so it
is a significant achievement for The Roslin
Institute to reach the silver award standard.
We were interested in seeing how our
actions are viewed in a wider context and in
developing our activities towards applying for
an Athena SWAN gold award. We applied
for a Workingmums.co.uk Top Employer
Award
(http://www.workingmums.co.uk/
topemployerawards/),
which
recognise
employers of all kinds who are progressive in
their flexible working practices and proactive
in seeking to retain talented staff, particularly
working parents who want to combine
successful careers with being a parent.
27 organisations were shortlisted in a range
of categories: The Roslin Institute was
shortlisted in the Family Support category
alongside BAE Systems, Danone Nutricia
Early Life Nutrition and the eventual category
winners, Bank of America Merrill Lynch.
Helen and Cat represented the Institute at the
awards event.
We were very impressed by the commitment
of a range of companies and organisations,
large and small, to providing flexible working
where possible to employees and seeing
real benefits in employee satisfaction and
productivity as a consequence. One category
that was won by the London School of
Economics was the “Best for Dads” employer
– any suggestions of additional support for
dads that we could put in place or suggest that
the University implement?
We also nominated The Roslin Institute
for a WISE Award (Women in Science and
Engineering (http://www.wisecampaign.org.
uk/ ) in the “Employer Award” category, which
recognises an employer who can demonstrate
an increase in the retention and progression of
women in scientific, technology, engineering
or mathematical roles as a result of actions
they have taken to enable women to achieve
their potential.
Professor Jean Manson, Head of the Institute’s
Neurobiology Division was also shortlisted
for a WISE Lifetime Achievement Award.
25
This award celebrates the achievements of
a woman who has had a truly outstanding
career in science, technology, engineering or
mathematics and has inspired and supported
other women to follow in her footsteps.
Jean and Helen Sang attended the WISE
Awards event in London, a formal dinner
hosted by Princess Anne, requiring the
wearing of “cocktail” dresses and corsages to
identify us as short-listed nominees.
The event was very interesting, with some
very impressive women nominated in different
categories, including young engineering
apprentices, dealing with being very much
in the minority in their roles and visiting
schools to encourage other girls to consider
engineering as a career.
It is very clear that major employers are
making big changes to their recruitment and
working practices as they recognise that they
need to increase the reach of their recruitment
and retention to be able to have the skilled
employees they need. Several commented
on additional benefits to all employees and to
company performance from the introduction of
flexible working, for example.
The highlight of the evening (for The
Roslin Institute) was the award of a Highly
Commended WISE Lifetime Achievement
Award to Jean Manson.
We learnt a lot from these events and are
always looking for suggestions for new
initiatives that we can develop, either within
The Roslin Institute or discuss at a College or
University level – so please get in touch with
[email protected] or helen.
[email protected]
Promotion success
T
he Roslin Institute is delighted to announce
that three of its Career Track Fellow, Dr
Gerry McLachlan, Dr Ross Houston and Dr
Barry McColl have all recently progressed to
be fully fledged Group Leaders at The Roslin
Institute.
Professor Bruce Whitelaw, Head of the
Developmental Biology Division at The Roslin
Institute, oversees Career Track Fellow
development, the scheme by which they can
achieve group leader status. He said of the
three recent promotions, “The Roslin Institute
is committed to recruiting the most talented
researchers then providing them with the
resources, training and mentoring that will
underpin their research in its early stages of
independence.
“Ross, Barry and Gerry are all talented
researchers who have all made excellent use
of what is available to them at The Roslin
Institute. Each has developed excellent,
competitive programmes of research on which
they will now continue to build their careers.”
G
erry’s focus is the development of lung
gene transfer technology. Through a
range of animal models he aims to understand
the lung response to physical injury and
evaluate new respiratory disease treatments.
For more about his research go to http://www.
roslin.ed.ac.uk/gerry-mclachlan/.
R
oss Houston undertakes research that
aims to advance the understanding of host
genetic regulation of disease resistance in
aquacultured species through the application
of genomics. More at http://www.roslin.ed.ac.
uk/ross-houston/.
B
arry McColl (centre) has developed a
group that is focussing on the neuroimmune interactions in health and disease.
Much of his research centres on the role of the
inflammatory response following a stroke. For
more, visit Barry’s web pages at http://www.
roslin.ed.ac.uk/barry-mccoll/.
26
Cake Bake
K
aren Bryson and Edith Paxton were two
of the Roslin Baking Army that raised
an impressive £260 at a bake sale in aid of
Macmillan Cancer Support. Well done to all
the bakers and also to all those with a sweet
tooth who briefly put aside will power and
succumbed to the temptation of brownies,
cupcakes, flapjacks and much more.
Cycle to Work Day
R
esearch scientist Marie O’Shea got The
Roslin Institute on its bike in September as
part of National Cycle to Work Day.
Since moving to its new building in 2011,
The Roslin Institute has been taking part in
schemes run by the University of Edinburgh
to get more of its staff and students cycling to
work. Covered cycle storage facilities, showers
and dedicated cycle paths have all improved
the lot of the Institute’s cyclists. However, Marie
and a small group of like-minded colleagues
are beginning to find new ways of encouraging
others to join them as they get to work in a
healthy and sustainable way.
One such activity was to get involved with the
National Cycle To Work Day 2014. Marie was
joined by 45 other cyclists who, between them,
covered 605.8 miles (roughly the distance from
Edinburgh to Land’s End).
To encourage everyone to get involved the Institute
provided participants with a free pastry and hot drink
in exchange for the hard-burned calories!
Marie congratulated all those who had taken to
two wheels for the day saying, “The conditions
were perfect for cycling and hopefully more
people will have been inspired to do it on a daily
basis! It was great to see the bike sheds so full.
The standard has been set for next year!”
Marathon Man!
D
r Ross Houston, Group Leader at The
Roslin Institute, ditched his labcoat in
favour of running shoes as he donned the
Scotland Team’s running strip and represented
his country in the 2014 Commonwealth Games.
Not only is Ross an outstanding geneticist
but he also showed himself to be the 16th
fastest man in the Commonwealth over a
distance of 26 miles when he took part in the
Commonwealth Games marathon. Ross’ time
was an impressive 2 hours 18 minutes and 42
seconds.
Everyone at The Roslin Institute was immensely
proud of Ross’ achievement and it was almost
as much of a talking point as the uniform he
wore at the opening and closing ceremonies.
Go Ross! Next stop Rio de Janeiro!!
27
BBSRC Postdoc group
D
r Prerna Vohra (right), a postdoctoral
research fellow in Professor Mark Stevens’
Group at The Roslin Institute has recently been
selected as a BBSRC postdoc representative
on the BBSRC Bioscience Skills and Careers
(BSC) Strategy Panel Postdoc Advisory Group.
Prerna recently attended a panel meeting at
which one of the main objectives was to find
ways to build the BBSRC postdoc community.
She said, “It was the first time postdocs have
been involved in skills and careers discussions
with the BBSRC, which is a huge opportunity
for us. To involve postdocs from all over the
country, a BBSRC Postdocs LinkedIn group
has been formed where we can discuss issues
and ideas that will go onto the agenda for the
next meeting. It is also a platform for sharing
knowledge and materials and supporting one
another.
“We, the postdoc representatives on the
panel, are also discussing ideas such as the
organisation of symposia for BBSRC funded
postdocs to showcase the variety of research
funded by the BBSRC and provide opportunities
for networking and building collaborations.
I would encourage all postdocs to join the
LinkedIn group.”
If you would like to know more or get involved,
please contact Prerna on Prerna.Vohra@
roslin.ed.ac.uk or the BBSRC on postdoc.
[email protected] and join the discussion
on the BBSRC Postdocs LinkedIn group.
Roslin Imaging’s Got Talent
T
he University of Edinburgh has a wide
variety of outstanding, state-of-the-art
imaging facilities across its campuses. These
facilities provide excellent resources for PhD
students at the University and their outputs
were celebrated at the recent “Imaging’s Got
Talent” competition organised by Edinburgh
Imaging and sponsored by Prof Joanna
Wardlaw, from Neuroimaging Sciences.
The winners, including two from The Roslin
Institute, were:
Rebecca Saleeb, IB3 (Best Presentation
Style),
Claire Davies, The Roslin Institute (Best
Scientific Content)
Anuj Sehgal, The Roslin Institute (Most
entertaining Presentation)
The Edinburgh Imaging event, which attracted
over 70 staff and students, was an excellent
opportunity for PhD students to mix with each
other.
Anuj Sehgal, a PhD student in Dr Neil
Mabott’s group at The Roslin Institute, said
of the competition, “Imaging’s Got Talent
was a very enjoyable meeting! The standards
of presentation were extremely high and
impressive; it is amazing how much information
people can get across in 3 minutes and also
manage to make it fun! I felt fairly confident
when I went to the meeting, but upon watching
some of the presentations before mine, I got
extremely nervous. In the end my three minute
presentation (‘Surveillance of CCTVs in the
gut’) was made easier because my nerves
made me speak faster.”
Claire Davies, a PhD student in Dr Barry
McColl’s group, won the prize for Best
Scientific Content (above). She presented
28
a time course of confocal images depicting
the inflammatory response in the brain and
discussed future plans to investigate cellular
changes and visualise cell interactions. She
hopes that understanding the mechanisms
that underlie inflammation and resolution will
eventually lead to the development of novel
therapeutics that could promote efficient
resolution in the brain and would have an
impact on numerous neurological conditions
that have an inflammatory aspect.
After the presentations the participants,
including students, post-docs, and senior
researchers from different universities across
Edinburgh, had the opportunity to mix over
pizza and refreshments.
Claire noted that The Roslin Institute was
represented well at ‘Imaging’s Got Talent’.
She was keen to thank Bob Fleming, manager
of The Roslin Institute’s Bioimaging Facility,
for all the help he has provided to Institute
scientists when their projects involved
imaging. It is a view shared by the many who
have benefited from the support offered by
Bob and his team and The Roslin Reporter
would like to congratulate Anuj and Claire
for being excellent ambassadors for Roslin
Bioimaging.
For more about Edinburgh Imaging please
visit its website www.ed.ac.uk/edinburghimaging and watch http://www.youtube.com/
watch?feature=player_embedded&v=CDXT2QhgS8.
Thomas Christopher Carter
27th December 1917 - 18th August 2014
T
he Roslin Institute was saddened to
hear of the death of Thomas Christopher
(Toby) Carter who was director of the Poultry
Research Centre, one of the early forms of
The Roslin Institute, in the 1960s.
Toby’s scientific career was initiated when he
obtained a first class Honours BA in Natural
Science at Cambridge University, followed
by an MA in the same discipline. While at
Cambridge Toby was involved, too, under
John Cockcroft, in the development of what
later became known as Radar.
When the Second World War broke out,
Toby’s Natural Science background, his flying
experience and his work on radar meant
that he was a natural choice when it came
to selecting people to set up radar stations
throughout Britain.
Toby was awarded an OBE Mil for a variety
of heroics during action in Asia and was
promoted to Wing Commander.
Toby moved to Cambridge after the war where
he embarked on a career in Animal Genetics,
which took him to Edinburgh, in 1948, where
he started to work on his first doctorate, a DSc
in Natural Sciences, and then, a couple of
years later, his second one, a PhD in Animal
Genetics. Toby worked in the MRC group
of the Institute of Animal Genetics, at King’s
Building, under Conrad Hal Waddington.
In 1954 Toby moved to Harwell with the
MRC. There he stayed until 1958, as Head of
the Genetics Section, working in the Animal
Genetics Division of the Medical Research
Council. A short break from Academia
followed. Toby was appointed scientific
director of all Western Chickens, based in
Devizes, Wiltshire. When Western Chickens
merged with Buxton Chickens, Toby returned
to Edinburgh, where he became scientific
director of Danny Marshall’s Chunky Chicks.
In 1961 Toby was lured away from the
business world and made Director of the
PRC (Poultry Research Centre), part of the
Agricultural Research Council. Toby retired
from the PRC based in Roslin, at the Roslin
Institute at the age of 60, in 1978. During the
course of his work at the PRC he was awarded
an FRSE from the Royal Society of Edinburgh.
Toby died on 18th August. He is survived by
his wife Jacquie and daughters Susan, Lucy
and Rosemary.
29
Connecting Science between Research Institutes
within the University
D
oug Vernimmen (Roslin) and Sari Pennings (QMRI) launched the idea to bridge the 4
campus together (Roslin, IGMM, SCRM/QMRI and KB) and to meet other people within the
UoE working on this topic.
With this connection, Edinburgh may be becoming the most powerful University in the UK for this
topic. So lets do what we can to make it stronger!
This meeting will take place 3 times a year (October, January and May) and will be a good
opportunity for students and postdocs to present their work in front of a specialised audience.
Moreover, it would give the opportunity to get feedback at the start/end of their project and also
good practice for conference, viva exams, grant/fellowship application, etc...
We also hope that these meetings will help to foster programme grants, PhD programmes
between labs and institutes in Edinburgh.
30
Roslin Supplier Fair
By Colin Millar
A
s any of our longer term residents will
know, at our old site we used to now and
again allow a sole supplier to loiter behind a
table in the Reception area for a day. This was
purportedly a “Supplier Exhibition” where the
rep would desperately try to raise interest from
sparse passing traffic in the various products
they had on offer. There were varying degrees
of success over the years and in comparison to
similar events round the Edinburgh area ours
were definitely low key.
However, once the dust sheets were cleared
from our wonderful new building in 2011, it
was immediately apparent that we had the
facilities to take things to a whole new level.
Initial sage advice from those in the know (the
editor included) was that we could perhaps
comfortably fit in 12-15 suppliers on the day.
Armed with a copy of the ground floor plan, (and
as our fledgling Summer Supplier Fair became
our Autumn Supplier fair and then finally our
Inaugural Xmas Supplier Fair) we stretched the
seams of that hypothesis somewhat.
Eventually on the day we had 30 Suppliers in
the building and many lessons learned for the
future, mainly don’t do talks at the same time as a
Supplier Fair. We repeated the event with similar
numbers in 2012 & 2013 with its reputation
growing as one of the key supplier events in the
Calendar. It’s new Halloween slot as well as tying
in with other local events also allowed a bit of a
fun theme. However, we were also conscious
that we were regularly turning away suppliers
due to space restrictions and there was the
danger of the event getting a bit stale.
So for 2014 we decided to stretch the seams of
the building a bit more by opening up the “Lower
Ground Atrium” (OK, the basement). This allowed
us to book in almost 50 supplier stands but did add
somewhat to the logistics involved in organising
the event. Arrangements were further challenged
by a total of 18 other events, leaving lunches or
meetings going on in the building around the time
31
of the
event.
We also this year
decided to extend a welcome across
campus and to other campuses by putting on a
shuttle bus service from Little France, KB and
the IGMM. It was good to see some of our wider
UoE colleagues taking the opportunity to visit the
event and this was well noted by the suppliers.
All of which added to what was a successful
event on the day and hopefully an opportunity
for all involved to network and catch up on the
latest developments in the lab market. Coolest
person on the day was Kevin from Dundee
Cell Products who was already calmly having
his first meeting at 9.30 while all around chaos
gradually subsided for the 10.00 start.
We have to extend thanks to all who got involved
on the day, the servitors team for helping to
shift every stick of furniture on the ground floor
and then putting it back how it was before, our
facilities team for pitching in with extension leads
and assistance at no notice, Dryden for once
again loan of extra tables, our comms team for
bouncing e-mail far and wide, Ray at Reception
for helping to shepherd lost suppliers, and of
course everyone else in the building who isn’t lab
based for putting up with it all.
As usual various fun activities and prize draws
enjoyed by all on the day. Our Star prize of an
iPad was won by one of the Senior Technicians
at SBS who had “enjoyed” the one glitch we
had in our bus scheduling which involved a
tour of Edinburgh via IGMM into the bargain.
Her comments on the card though summed up
the spirit of the event, “Only visited the stands
related to my work”.
The Supplier Fair will take place again next
year on 29th October so if you would like to
know more, please contact the Institute’s
procurement office via roslin.stores@roslin.
ed.ac.uk.
2015 Genetics Society Spring Meeting
Breeding for Bacon,
Beer and Biofuels
16 –17 April 2015. The Roslin Institute, Edinburgh
The growing world population demands a sustainable intensification
of agricultural production across the globe. At the same time
there is competition for land use and we have to mitigate both the
causes and consequences of climate change. This poses a range of
challenges for plant and animal breeders who have to select the
genotypes that are best suited to future production circumstances
which are uncertain.
At the same time, technological and methodological advances
provide breeders with a range of tools to accelerate genetic progress
and enable ‘precision breeding’. This meeting will bring together
scientists from different disciplines related to artificial selection
and highlight different aspects on how genetics continues to be
a cornerstone of food production. The topics of the meeting will
be across plant and animal species and range from domestication
of new species for agriculture to genomic selection, genetic
modification and novel phenotyping approaches.
for registration, visit
www.genetics.org.uk
32
Speakers
Li-Hua Zhu, Swedish University of Agricultural Sciences
Thomas Lubberstedt, Iowa State University
Jennie Pryce, La Trobe University
Helen Sang, The Roslin Institute, University of Edinburgh
Chris-Carolin Schön, Technische Universität München
Alison Bentley, The John Bingham Laboratory
Graham Moore, John Innes Centre
Catherine Howarth, University of Aberystwyth
John Hickey, The Roslin Institute, University of Edinburgh
Anna Sonesson, Nofima
Scientific Organisers
Helen Sang, Roslin Institute, University of Edinburgh
Alan Archibald, Roslin Institute, University of Edinburgh
Ian Mackay, NIAB
DJ de Koning, Swedish University of Agricultural Sciences
Coming and Going
A
s always The Roslin Institute has seen
a large number of new starts in recent
months. Of particular note on that score is the
new cohort of PhD students, which has been
settling in and getting to grips with lab life. We
at the Roslin Reporter wish them well for their
studies and look forward to hearing about their
awards, collaborations and massive scientific
achievements over the coming years.
O
f-course, as we welcome new faces we
also bid fond farewells to the slightly
better known. One such face is that of Lesley
Penny who has been the named vet at The
Roslin Institute since 1999. Lesley has been
a key member of many research teams and
has been really important in providing robust
advice and animal care throughout her
tenure at the Institute. At a very well attended
gathering in July, Institute Director, David
Hume, thanked Lesley for her dedication to
her job and for being such a great person to
work with. Lesley has moved on to take the
role of Director of Veterinary Services at the
University of Edinburgh and we wish her well
and look forward to continued interactions with
her in that role.
T
he other big loss to The Roslin Institute
team is Sheelagh Strachan who retires
this year. Sheelagh joined the Institute in
1989 (when it was still part of the Agricultural
and Food Research Council) and has since
worked at the farm, in finance and latterly as
a Departmental Administrator for the Division
of Developmental Biology. Over the years she
has become an asset to the Division and the
wider Institute and Bruce Whitelaw, Head of
the Division said, “It has been a real pleasure
working with Sheelagh over the years. From
being a welcoming face for new starts to
resolving issues for the older faces in the
Division, Sheelagh will be fondly remembered
by all in Developmental Biology. We wish her
a wonderful retirement.” Sheelagh is looking
forward to retirement and spending more time
with family. It’s well deserved
33
Tricia follows her man to pastures new
O
ur third big loss is the departure of Tricia
Hart. Tricia has been with Roslin and
its predecessors since 2001. First as post
doc in NPU and latterly as the Scientific
Administrator. She will be hard act to follow,
both as science administrator and pantomime
villain. Bruce Whitelaw, Head of Division siad
“Tricia’s energy and diplomacy has been felt
by most people in the Institute. Her willingness
to prompt, ability to see things before they
I
n her own words “my wanderlust has got the
better of me so I am lacing up my seriously
cool new DMs and disappearing to Sheffield”. Hopefully Tricia will not disappear and find the
opportunity to visit Roslin in the future.
2014 Pantomime
Y
es, it’s that time of year again! The Roslin
Institute Building Players were back in full
costume to sing and giggle their way through
the annual pantomime, which this year was
“The Wizard of rOzlin”. Complete with flying
monkeys and super-sized Toto the cast
were on fine form. Dorothy, the tin man, the
scarecrow and the cowardly lion all managed
to get themselves through a series of
challenging seminars and lab incidents before
finally finding the way to secure their dreams
and kill the wicked witch, thus overcoming her
constant rejection of their funding applications.
With SRUC’s Jos Houdijk in fabulous drag
and Tricia Hart overacting for the last time
before she leaves The Roslin Institute for
Sheffield’s seven hills the most was made of
Aileen, Lucy’s and Alex’s script. Much fun was
had by all as always. For now the makeup is
back in the box and the costumes returned
to their covers. Let’s see what drama 2015
brings!
34
happen and determination to get things done
have been a real asset to Roslin. I am sure
everyone but especially the SMG wish her all
the very best in her future position.”
Recent Roslin Institute Publications
Aghamaleky Sarvestany, A., Hunter,
G., Tavendale, A., Lamont, D.J.,
Llavero Hurtado, M., Graham, L.C.,
Wishart, T.M. and Gillingwater,
T.H. (2014) Label-Free Quantitative
Proteomic
Profiling
Identifies
Disruption of Ubiquitin Homeostasis
As a Key Driver of Schwann Cell
Defects in Spinal Muscular Atrophy.
Journal of Proteome
Research E-pub 26 August, DOI:
10.1021/pr500492j.
Angers, R., Christiansen, J., Nalls,
A.V., Kang, H.E., Hunter, N., Hoover,
E., Mathiason, C.K., Sheetz, M. and
Telling, G.C. (2014) Structural effects
of PrP polymorphisms on intra- and
interspecies prion transmission.
Proc Natl Acad Sci U S A 111(30),
11169-11174, DOI:
10.1073/
pnas.1404739111.
Arner, E., Forrest, A.R.R., Ehrlund,
A., Mejhert, N., Itoh, M., Kawaji, H.,
Lassmann, T., Laurencikiene, J.,
Rydén, M., Arner, P. and The Fantom
Consortium (2014) Ceruloplasmin
Is a Novel Adipokine Which Is
Overexpressed in Adipose Tissue
of Obese Subjects and in ObesityAssociated Cancer Cells. PLoS One
9(3), e80274, DOI: 10.1371/journal.
pone.0080274.
Arnold, M.F.F., Caro-Hernandez, P.,
Tan, K., Runti, G., Wehmeier, S.,
Scocchi, M., Doerrler, W.T., Walker,
G.C. and Ferguson, G.P. (2014)
Enteric YaiW is a surface-exposed
outer membrane lipoprotein that affects
sensitivity to an antimicrobial peptide.
Journal of Bacteriology 196(2), 436444, DOI: 10.1128/jb.01179-13.
Aungier, S.R., Ohmori, H., Clinton, M.
and Mabbott, N.A. (2014) MicroRNA100-5p indirectly modulates the
expression of Il6, Ptgs1/2 and Tlr4
mRNA in the mouse follicular dendritic
cell-like cell line, FL-Y. Immunology,
DOI: 10.1111/imm.12342.
Balic, A., Garcia-Morales, C.,
Vervelde, L., Gilhooley, H., Sherman,
A., Garceau, V., Gutowska, M.W.,
Burt, D.W., Kaiser, P., Hume, D.A.
and Sang, H.M. (2014) Visualisation
of chicken macrophages using
transgenic reporter genes: insights
into the development of the avian
macrophage lineage. Development
141(16), 3255-3265, DOI: 10.1242/
dev.105593.
Banks, G., Heise, I., Starbuck, B.,
Osborne, T., Wisby, L., Potter, P.,
Jackson, I.J., Foster, R.G., Peirson,
S.N. and Nolan, P.M. (2014) Genetic
background influences age-related
decline in visual and nonvisual
retinal responses, circadian rhythms,
and sleep. Neurobiology of Aging
E-pub 2 August, DOI: 10.1016/j.
neurobiolaging.2014.07.040.
Barnett, T.P., Hawkes, C.S. and
Dixon, P.M. (2014) Tracheal
Resection and Anastomosis After
Traumatic Tracheal Stenosis in a
Horse. Veterinary Surgery E-pub 10
September, DOI: 10.1111/j.1532950X.2014.12270.x.
Barron, R. (2014) Prion disease
zoonosis: assessing risk associated
with new and emerging prion agents.
CAB Reviews 9(023), DOI: 10.1079/
pavsnnr20149023.
Bartley, K., Deane, D., Percival, A.,
Dry, I.R., Grant, D.M., Inglis, N.F.,
McLean, K., Manson, E.D.T., Imrie,
L.H.J., Haig, D.M., Lankester, F. and
Russell, G.C. (2014) Identification
of immuno-reactive capsid proteins
of malignant catarrhal fever
viruses. Veterinary Microbiology
173(1-2), 17-26, DOI: 10.1016/j.
vetmic.2014.07.004.
Beard, P.M., Griffiths, S.J., Gonzalez,
O., Haga, I.R., Pechenick Jowers,
T., Reynolds, D.K., Wildenhain,
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