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Template of your Research Competition Submission File
Title/Name of your research study here
Author 1, Author 2, Author 3, Author 4
Primary Team Leader Full Name (Teacher)
School name
Email of Primary Team Leader only
Methods
Background
Autophagy
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsd
nvkldsnvklsdnvkkkck dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld
dlkkd dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm f,s ;kdfmgs, ;gm;lsg
s gs;ls gs ddpspspsp spososos spspsps sopsoos sosoos sosos soso
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsdnvkl
dsnvklsdnvkkkck dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld dlkkd
dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm f,s ;kdfmgs, ;gm;lsg s gs;ls gs
ddpspspsp spososos spspsps sopsoos sosoos sosos soso
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsd
nvkldsnvklsdnvkkkck dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld
dlkkd dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm f,s ;kdfmgs, ;gm;lsg
s gs;ls gs ddpspspsp spososos spspsps sopsoos sosoos sosos soso
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsdnvkl
dsnvklsdnvkkkck dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld dlkkd
dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm f,s ;kdfmgs, ;gm;lsg s gs;ls gs
ddpspspsp spososos spspsps sopsoos sosoos sosos soso
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsd
nvkldsnvklsdnvkkkck dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld
dlkkd dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm f,s ;kdfmgs, ;gm;lsg
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsdnvkl
dsnvklsdnvkkkck dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld dlkkd
dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm f,s ;kdfmgs, ;gm;lsg s gs;ls gs
Results
0.5
0.0
CS
1.0
-
-
-
-
+
+
+
+
0.5
0.0
RIP 1
MLKL
MLKL
-
+
+
+
A
R
1.0
1.0
0.5
0.5
CS
A
0.0
0.0
R
Beclin normalized to actin and RA
CS
P62 normalized to actin
CS
LC3B bottom band
RIP3
RIP1
1.5
1.0
0.5
0.0
2.5
2.0
1.5
1.0
0.5
0.0
MLKL
1.5
CS
1.0
-
RIP 3
0.5
CS
R
A
0.0
Fig. A(i&ii) Autophagy markers in cardiac tissue of 6 months cigarette smoked mice
and wild type mice
Fig. B(i&ii) Necroptosis markers in cardiac tissue of 6 months cigarette smoked mice
and wild type mice
-
-
+
+
+
1.0
0.5
0.0
CS
-
0.0
1.5
Fig. D(ii)
1.5
0.5
RIP3 normalized to actin and RA
1.0
Fig. D(i)
RIP3
2.0
1.0
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc
fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklz
dnvkldsnvlksdnvkldsvnklsdnvkldsnvklsdnvkkkc
k dkdnksdkds dskd;kds;lds dkdkd ldld dldld
dldld dlkkd dkddio ldldld dldldl dld dldld
ldldm;lmsl s;dsm f,s ;kdfmgs, ;gm;lsg s gs;ls gs
ddpspspsp spososos spspsps sopsoos sosoos
sosos soso
C
S
1.5
CS
CS
A
RIP1
1.5
LC3B bottom band normalized to actin and RA
P62
0.0
LC3B
1.5
CS
0.0
MLKL normalized to actin and RA
RIP 3
-
A
0.5
1.5
CS
R
Beclin
2.0
0.0
A
0.5
R
MLKL
+
LC3B
1.0
A
RIP 1
+
A
+
+
R
+
+
MLKL normalized to actin and RA
+
-
0.5
A
+
-
1.0
R
-
-
1.5
R
1.0
Rip3 heart normalized to actin and RA
-
LC3B bottom band
-
1.5
C
S
-
LC3B bottom band normalized to actin and RA
R
LC3B
R
LC3B normalized to actin and Ra
-
CS
0.0
1.5
Fig. B(ii)
RIP1 normalized to actin and RA
Fig. B(i)
Fig. C(ii)
0.5
LC3B normalized to actin and Ra
+
CS
+
A
+
A
+
R
-
Fig. C(i)
R
-
1.0
A
-
P62
Beclin
1.5
CS
Fig. A(ii)
LC3B
CS
Beclin normalized to actin and RA
Fig. A(i)
CS Beclin
Hepatic Tissue
Beclin
RIP1 normalized to actin and RA
Cardiac Tissue
Fig. C(i&ii) Autophagy markers in hepatic tissue of 6 months cigarette smoked mice
and wild type mice
Fig. D(i&ii) Necroptosis markers in hepatic tissue of 6 months cigarette smoked mice
and wild type mice
Conclusions
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsdnvkldsnvklsdnvkkkck
dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld dlkkd dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm
f,s ;kdfmgs, ;gm;lsg s gs;ls gs ddpspspsp spososos spspsps sopsoos sosoos sosos soso
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzdnvkldsnvlksdnvkldsvnklsdnvkldsnvklsdnvkkkck
dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld dlkkd dkddio ldldld dldldl dld dldld ldldm;lmsl s;dsm
f,s ;kdfmgs, ;gm;lsg s gs;ls gs ddpspspsp spososos spspsps sopsoos sosoos sosos soso
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc
fflfll dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklz
dnvkldsnvlksdnvkldsvnklsdnvkldsnvklsdnvkkkc
k dkdnksdkds dskd;kds;lds dkdkd ldld dldld
Future Research:
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll
dkdkdkd dlldld ldldl ld
mlkxcnvkldnvkldnvlkdnvlkdsnvlkdsnvlkzdnvklzd
nvkldsnvlksdnvkldsvnklsdnvkldsnvklsdnvkkkck
dkdnksdkds dskd;kds;lds dkdkd ldld dldld dldld
dlkkd dkddio ldldld dldldl dld dldld ldldm;lmsl
s;dsm f,s ;kdfmgs, ;gm;lsg s gs;ls gs ddpspspsp
spososos spspsps sopsoos sosoos sosos soso
aLSKcnlaksnclkn lkn lknvlkd`nvkldsnvkc klc fflfll
dkdkdkd dlldld ldldl ld

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