docPlatelet Function - Thrombosis and Hemostasis Societies of North
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Platelet Function - Thrombosis and Hemostasis Societies of North
Platelet Function Alan D. Michelson Professor of Pediatrics and Professor of Medicine Harvard Medical School Director, Center for Platelet Research Studies Director, Thrombosis and Anticoagulation Program Boston Children’s Hospital, Dana-Farber Cancer Institute Disclosures Principal investigator or co-investigator on research grants to Boston Children’s Hospital from BristolMyers Squibb, Eisai, GE Global Research, GLSynthesis, Lilly, Megakaryon, Pfizer and Sysmex. Data monitoring boards of clinical trials sponsored by Lilly. Advisory board: AstraZeneca, Instrumentation Laboratory, Momenta. What is a person in North America most likely to die from? 1. Cancer 2. Infection 3. An accident 4. A platelet-related disease What is a person in North America most likely to die from? Acute Myocardial Infarction 4. A platelet-related disease Coronary Artery Thrombosis Weisel in PLATELETS (Michelson, 3rd edition, Elsevier/Academic Press, 2013) Platelet Function • 3 Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Antiplatelet Agents FDA-approved Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Antiplatelet Agents FDA-approved Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Antiplatelet Agents FDA-approved Micelson Nature Reviews Drug Discovery 2010;9:154-169 Antiplatelet Agents FDA-approved Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Antiplatelet Agents FDA-approved Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Antiplatelet Agents FDA-approved Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function Bernard-Soulier syndrome Platelet-type VWD GPVI defect α2β1 defect Receptors for Adhesive Proteins Glanzmann thrombasthenia Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function P2Y12 defect Receptors for Soluble Agonists TXA2 receptor defect Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function α-storage pool deficiency (gray platelet syndrome) α-Granules Quebec platelet disorder Paris-Trousseau syndrome/11-q terminal deletion disorder Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function δ-storage pool deficiency Hermansky-Pudlak syndrome Dense Granules Chediak-Higashi syndrome Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function α-Granules and Dense Granules α,δ-storage pool deficiency Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function Signal Transduction G proteins Phospholipase A2 Phospholipase C COX1 Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Congenital Disorders of Platelet Function Procoagulant Phospholipids Scott syndrome Stormorken Modified from Michelson Nature Reviews Drug Discovery 2010;9:154-169 Bernard-Soulier Syndrome Cattaneo in PLATELETS (Michelson, 3rd ed, Elsevier/Academic Press, 2013) MYH9-Related Disease Lambert & Poncz in PLATELETS (Michelson, 3rd ed, Elsevier/Academic Press, 2013) 2013;121:250 2013;121:250 Michelson in PLATELETS (Michelson, 3rd ed, Elsevier/Academic Press, 2013) Barnard & Michelson NEJM 1995;333:1051
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