baish hiden ng publ lishin ng gro oup inc c

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baish hiden ng publ lishin ng gro oup inc c
BAISH
HIDEN
NG PUBL
LISHIN
NG GRO
OUP INC
C
7901 Sto
oneridge D
Drive, Suitee 501, Pleassanton, CA
A 94588, US
SA
Telepho
one: +1-9255-223-8242
Fax: +1-925-2223-8243
E-mail: [email protected]
@wjgnet.co
om
htttp://www
w.wjgnet.co
om
PEER-RE
EVIEW REPORT
R
T
Name off journal: World
W
Jourrnal of Gasstroenterology
Manuscrript NO: 322607
Title: 8--week Leedipasvir/S
Sofosbuvirr Therapy
y in Non
n-Cirrhoticc, Treatm
ment-naïve
Hepatitiss C Genotype-1 Patients with
th HCV-RN
NA < 6 million
m
IU
U/mL: Real World
Effectiveeness and Safety
S
Revieweer’s code: 02861175
0
Revieweer’s country
y: Indonessia
Science eeditor: Ze--Mao Gong
g
Date sen
nt for revieew: 2017-01
1-18
Date rev
viewed: 20117-01-22
CLASSIFIC
CATION
LANGUAGE EVALU
UATION
SCIENTIFIC
C MISCONDU
DUCT
CON
NCLUSION
[
] Grade A
A: Excellent
[ ] Grad
de A: Priority publishing
Google Searcch:
A
[ Y] Accept
[
] Grade B
B: Very good
[ Y] Grad
de B: Minor lan
nguage
[
] The sam
me title
[
[
] Duplicate publication
n
[
] Plagiarism
[ Y] Grade C
C: Good
polisshing
[
] Grade D
D: Fair
[ ] Grad
de C: A great d
deal of
[
] Grade E
E: Poor
lang
guage polishin
ng
[ ] Grad
de D: Rejected
d
] High
H
priority for
f
publication
p
[
] Rejection
R
[ Y ] No
[
] Minor
M
revision
n
BPG Search:
[
] Major
M
revision
n
[
] The sam
me title
[
] Duplicate publication
n
[
] Plagiarism
[ Y ] No
COMME
ENTS TO AUTHOR
A
RS
over all tthis study is good, itt's importaant knowleedge for cllinicians bbefore treatting HVC
patients. There arre some comments:
c
1. What is the clin
nical reasoon of using
g 8 week
DAAs tx
x? please ex
xplain in th
he introdu
uction 2.w
why you ch
hoose HCV
V RNA 8.0
000.000 as
cut off in
n bi-variatee and uni-v
variate anaalyses? please explain
n it? if you
u want to determine
d
the cut o
of point, AU
UROC ana
alyses is th
he availablle cut off. 3. Explan
nation of fiigure 1 as
the subjeect selection
n must be placed in sstudy popu
ulation.
1
BAISH
HIDEN
NG PUBL
LISHIN
NG GRO
OUP INC
C
7901 Sto
oneridge D
Drive, Suitee 501, Pleassanton, CA
A 94588, US
SA
Telepho
one: +1-9255-223-8242
Fax: +1-925-2223-8243
E-mail: [email protected]
@wjgnet.co
om
htttp://www
w.wjgnet.co
om
PEER-RE
EVIEW REPORT
R
T
Name off journal: World
W
Jourrnal of Gasstroenterology
Manuscrript NO: 322607
Title: 8--week Leedipasvir/S
Sofosbuvirr Therapy
y in Non
n-Cirrhoticc, Treatm
ment-naïve
Hepatitiss C Genotype-1 Patients with
th HCV-RN
NA < 6 million
m
IU
U/mL: Real World
Effectiveeness and Safety
S
Revieweer’s code: 02860814
0
Revieweer’s country
y: Greece
Science eeditor: Ze--Mao Gong
g
Date sen
nt for revieew: 2017-01
1-18
Date rev
viewed: 20117-01-25
CLASSIFIC
CATION
LANGUAGE EVALU
UATION
SCIENTIFIC
C MISCONDU
DUCT
CON
NCLUSION
[
] Grade A
A: Excellent
[ ] Grad
de A: Priority publishing
Google Searcch:
[
A
] Accept
[
] Grade B
B: Very good
[ Y] Grad
de B: Minor lan
nguage
[
] The sam
me title
[
] High
H
priority for
f
[
] Duplicate publication
n
[
] Plagiarism
[ Y] Grade C
C: Good
polisshing
[
] Grade D
D: Fair
[ ] Grad
de C: A great d
deal of
[
] Grade E
E: Poor
lang
guage polishin
ng
[ ] Grad
de D: Rejected
d
publication
p
[
] Rejection
R
[ Y ] No
[
] Minor
M
revision
n
BPG Search:
[ Y] Major
M
revision
n
[
] The sam
me title
[
] Duplicate publication
n
[
] Plagiarism
[ Y ] No
COMME
ENTS TO AUTHOR
A
RS
(1) The o
overall stru
ucture of th
he manusccript needss to be com
mpleted (aabstract, keeywords).
(2) The aauthors (in
n the “Stud
dy populattion” sectio
on) refer that accord
ding to thee protocol
constructted, the close moniitoring of patients during
d
treatment w
was docum
mented by
laboratorry testing every
e
2 weeeks. It is sttrange to me
m and I ne
eed a comm
ment on th
his, taking
account that this is
i a real life
l
study and in ev
very day clinical
c
prractice lab tests are
suggested to be peerformed on
o wk2, w
wk4, eot and svr12. (3
3) Patientss who misssed doses
were exccluded. Wh
hich was the
t criterio
on exactly for this (h
how many doses?). (4)
( Which
was the method for HCV RNA
R
test aand what was the cut-offs?
c
(55) Which were the
criteria ffor the clin
nical judgm
ment of th
he presencce/absence
e of cirrhoosis. (6) Pa
age 8, 1st
sentence “value of
o HCV-RN
NA level for SVR is
i currently availabble data”: It is not
compreh
hensible, neeed to be reconstruccted. (7) Th
he authorss should d
discuss and
d provide
their exp
planations for
f the diffferences off their resu
ults with other
o
studiees. (8) According to
2
BAISH
HIDEN
NG PUBL
LISHIN
NG GRO
OUP INC
C
7901 Sto
oneridge D
Drive, Suitee 501, Pleassanton, CA
A 94588, US
SA
Telepho
one: +1-9255-223-8242
Fax: +1-925-2223-8243
E-mail: [email protected]
@wjgnet.co
om
htttp://www
w.wjgnet.co
om
which claassification
n the fibrosis score w
was classifiied to stag
ge “0”, “1”,, “3”, “3-4”
”, “4”. (9)
Tables sh
hould be reeconstructeed accordiing to journ
nal guideliines (i.e. roow 4 in Tab
ble 2). (10)
P-values for non-siignificant differences
d
s should be added in
n Table 2. ((11) Figuree 2: There
is a disco
ordance with factors and numb
ber of barss. (12) Kow
wdley et all recently published
p
in Hepattology 20166 data indiicating thee effectiven
ness of an 8-week du
uration of treatment
t
with LDV
V/SOF. (13) Similarlly, Lai et aal publisheed their results in Drrugs 2017, showing
that 8-weeeks coursses of LDV
V/SOF are comparab
ble to 12-week coursees in real world
w
use
among seelected pattients supp
ported by a multidiscciplinary te
eam.
3
BAISH
HIDEN
NG PUBL
LISHIN
NG GRO
OUP INC
C
7901 Sto
oneridge D
Drive, Suitee 501, Pleassanton, CA
A 94588, US
SA
Telepho
one: +1-9255-223-8242
Fax: +1-925-2223-8243
E-mail: [email protected]
@wjgnet.co
om
htttp://www
w.wjgnet.co
om
PEER-RE
EVIEW REPORT
R
T
Name off journal: World
W
Jourrnal of Gasstroenterology
Manuscrript NO: 322607
Title: 8--week Leedipasvir/S
Sofosbuvirr Therapy
y in Non
n-Cirrhoticc, Treatm
ment-naïve
Hepatitiss C Genotype-1 Patients with
th HCV-RN
NA < 6 million
m
IU
U/mL: Real World
Effectiveeness and Safety
S
Revieweer’s code: 02861252
0
Revieweer’s country
y: Turkey
Science eeditor: Ze--Mao Gong
g
Date sen
nt for revieew: 2017-01
1-18
Date rev
viewed: 20117-01-28
CLASSIFIC
CATION
LANGUAGE EVALU
UATION
SCIENTIFIC
C MISCONDU
DUCT
CON
NCLUSION
[
[ Y] Grad
de A: Priority p
publishing
Google Searcch:
A
[ Y] Accept
[ ] Grad
de B: Minor lan
anguage
[
] The sam
me title
[
[
] Duplicate publication
n
[
] Plagiarism
] Grade A
A: Excellent
[ Y] Grade B
B: Very good
[
] Grade C
C: Good
polisshing
[
] Grade D
D: Fair
[ ] Grad
de C: A great d
deal of
[
] Grade E
E: Poor
lang
guage polishin
ng
[ ] Grad
de D: Rejected
d
] High
H
priority for
f
publication
p
[
] Rejection
R
[ Y ] No
[
] Minor
M
revision
n
BPG Search:
[
] Major
M
revision
n
[
] The sam
me title
[
] Duplicate publication
n
[
] Plagiarism
[ Y ] No
COMME
ENTS TO AUTHOR
A
RS
Good wo
ork... Study
y Highligh
hts ? Validaation of cliinical outcome with high overa
all SVR24
96% in seelected sub
bset of pattients with
h HCV infeection and good safetty profile in a large
real-worlld cohort NOT SV
VR 24 .....SVR 12 must be....
in taable ≥800.000 and
≤800.000 ???..800.0000< and ≥8
800.000 F igure 2 so complicate
ed??
4

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