CURRICULUM VITAE - Vanderbilt University Medical Center

CURRICULUM VITAE - Vanderbilt University Medical Center

CURRICULUM VITAE
Edwin John Weeber, Ph.D.
Personal Data
Address
Phone
E-mail
Lab URL
Vanderbilt University Medical Center
Department of Molecular Physiology and Biophysics
Robinson Research Building #754
Nashville TN. 37213-0615
Office: (615) 343-1312
Lab: (615) 343-1311
[email protected]
www.mc.vanderbilt.edu/root/vumc.php?site=weeber&doc=6448
Education
1993
B.S., Biology, University of New Mexico, Department of Biology,
Albuquerque, NM.
Ph.D., Neuroscience, University of New Mexico, College of Medicine, Department of
Neuroscience, Albuquerque, NM.
1998
Professional Experience
Post Doctoral Training
1999-2002
Post-doctoral Fellow, Laboratory of Dr. J D Sweatt, Division of Neuroscience, Baylor
College of Medicine, Houston, Texas.
Academic Appointments
2001-2002
Research Instructor,
Division of Neuroscience, Baylor College of Medicine, Houston, TX.
Assistant Professor,
Division of Neuroscience, Baylor College of Medicine, Houston, TX.
Assistant Professor,
Department of Molecular Physiology and Biophysics, John F. Kennedy Center for
Research in Human Development, Center for Molecular Neuroscience, Vanderbilt
University Medical Center, Nashville TN.
Joint appointment, Department of Pharmacology, Vanderbilt University Medical
Center, Nashville TN
2002-2003
2004-Present
2005-Present
Awards and Honors
2004
2003
2003
2000
1999-2002
1997-1998
1994-1995
1993-1994
National Alliance for Research on Schizophrenia and Depression (NARSAD) Young
Scientist Award
American Federation for Aging Research (AFAR) Award
Cynthia and George Mitchell Awards in Dementia Research
Travel Award, American College of Neuropsychopharmacology / Puerto Rico
NINDS, Post-doctoral Supplemental Grant for Underrepresented Minorities
Minority Biomedical Research Sciences (MBRS) Pre-doctoral Fellowship
Patricia Harris Minority Pre-doctoral Fellowship Award
Research Improvements for Minority Institutions (RIMI) Pre-doctoral Fellowship
Trainees
Graduate Students
2004-Present
2005-Present
2006-Present
Kimberly Korwek, B.A.; Hiram College
Richard Gustin, B.S. University of Miami
Nicole Speed, B.S. SUNY, Albany
Undergraduate Students
2004-2005
Courtney Young, Summer Neuroscience Apprentice Program (SNAP)
2005-2006
Karen Harris, Savannah State., Initiative for Minority Student Development (IMSD)
Other Trainees
2002-2003
2005-Present
Grace Cortez-Jackson, M.D. Baylor College of Medicine. MD research Track
Program.
Current position: Resident in Pathology, UTMB.
Lisa Zhao, B.S.; UCLA, Med Scholar Program
Post Doctoral Fellows
2004-Present
Shenfeng Qiu, Ph.D. University of California, Riverside, CA.
2006
Jessica Banko, Ph.D. Baylor College of Medicine, Houston, TX.
Current position: Assistant Director for Sponsored Research,
Vanderbilt University, Nashville, TN
PH.D. Dissertation Committees
Graduated
Nicholas Trotta
Jennifer Edl
Jana Shirey
Liza Nikandrova
Ashleigh Long
Heather Gosnell
Angela Shields
Elizabeth Haldeman
Mica Bergman
Adeola Pratt
Ph.D. 2005
Dept. of Biological Sciences, Vanderbilt University
Dept. of Pharmacology, Vanderbilt University
Dept. of Pharmacology, Vanderbilt University
Dept. of Mol. Phys., Vanderbilt University
Biological Sciences, Vanderbilt University
Dept. of Mol. Phys., Vanderbilt University
Dept. of Mol. Phys., Vanderbilt University
Neuroscience, Vanderbilt University
Neuroscience, Vanderbilt University
Neuroscience, Vanderbilt University
Teaching Experience
Undergraduate
1997
Laboratory Instructor, Microbiology (352), University of New Mexico
1996
Lecturer, Microbiology (350), University of New Mexico
1996-1997
Laboratory Instructor, Microbiology (238), University of New Mexico
Graduate
2006
2005-2006
2005-2006
2005-2006
2004-2006
2004
Coordinator Graduate Student Seminar Series
Instructor, Neuroscience Foundations (325), Vanderbilt University Medical Center
Course Director, Graduate Tutorials (MPB324), Vanderbilt University Medical Center
Lecturer, Cellular and Molecular Neuroscience (345), Vanderbilt University Medical Center
Lecturer, Systems and Integrative Neuroscience (340), Vanderbilt University Medical Center
Lecturer, Molecular Mechanisms of Learning and Memory, Baylor College of Medicine
Professional Membership
American Academy for the Advancement of Science (AAAS)
American Society for Neurochemistry (ASN)
Molecular and Cellular Cognition Society
Society for Neuroscience (SFN)
Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)
National Scientific Participation
Editorial Board: Molecular Neurodegeneration
Editorial Board: International Archives of Bioscience
NINDS Special Study Section grant reviewer
UK Medical Research Council (MRC) grant reviewer
U.S. Civilian Research and Development Foundation (CRDF) grant reviewer
Alzheimer’s Disease Research Grants Program grant reviewer
Manuscript Referee for:
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Brain Research
Behavioral Brain Research
Current Opinion in Neuroscience
EMBO
Hippocampus
Journal of Comparative Neurology
Journal of Neurochemistry
Journal of Neurophysiology
Journal of Neuroscience
Journal of Neuroscience Methods
Journal of Neuroscience Research
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Journal of Physiology
Learning and Memory
Molecular and Cellular Biology
Nature Neuroscience Reviews
Neuroscience and Biobehavioral Reviews
Neuropsychopharmacology
Neurobiology of Learning and Memory
Pharmacology, Biochemistry and Behavior
Psychopharmacology
Synapse
Presentations:
2000
“Disregulation of CamKII in Angelman Human Mental Retardation Syndrome”
Society for Neuroscience National Conference, New Orleans, LA.
2001
“Modulation of Synaptic Function by Omega 3 Fatty Acids”
Society for Neuroscience National Conference, San Diego, CA.
2003
“Angelman Human Mental Retardation Syndrome: From Mouse Models to Molecular Mechanisms”
The Gladstone Institute of Neurological Disease, San Francisco, CA.
“The Emerging Role of Lipoprotein Receptors in Synaptic Function and Memory Processes”
Vanderbilt University, Nashville, TN.
“Lipoprotein receptors: Insights into the Memory Loss and Pathology Associated with Alzheimer’s
Disease” Learning and Memory Conference, Cold Spring Harbor, NY.
“ApoER2 and VLDLR Receptors in Hippocampal Function and Memory Formation”
UTSW at Dallas, Dallas, TX.
“ApoE Receptors and Human Cognition: A Missing Piece of the Alzheimer’s Disease Puzzle?” The
Huffington Center on Aging, Baylor College of Medicine, Houston, TX.
“Reelin Receptors, Synaptic Function and Schizophrenia”
Maryland Psychiatric Research Center, Baltimore MD.
2004
“ApoE in Alzheimer’s Disease”
3rd annual Alzheimer’s Disease Consortium, League City, TX.
“Discrete Reelin Signaling Involves Differential Splicing and Direct Coupling to NMDA Receptors”
Spring Hippocampal Research Conference, Grand Cayman, BWI
“ApoE and Alzheimer’s Disease” Minisymposium, Society for Neuroscience National Conference,
San Diego, CA.
2005 “Consequences of Diminished Reelin Signaling on Adult Synaptic Transmission and Plasticity”,
Spring Hippocampal Conference, Sedona, AZ
2006
“The Role of Reelin in Synaptic Function and Dysfunction; a Matter of Development, or Signaling?”
NIH/NIEHS, Raleigh, NC.
“Reelin signaling and Schizophrenia; from mouse models to molecular mechanisms.”
University of New Mexico, Albuquerque, NM.
“Alterations in CaMKII Phosphorylation can Rescue the Cognitive and Synaptic Plasticity Defects in
a Mouse Model for Angelman Syndrome Human” Epigenetics & Neural Developmental Disorders
conference, Washington D.C.
"Reelin, cognition and schizophrenia: Uncovering the truth about the ‘axons of evil’"
Georgetown University, Washington, D.C.
Research Support:
Prior Support:
1999-2001
Research Supplement for underrepresented minorities. Parent Grant: NINDS, “Regulation of
Neuronal Excitability” (1 PO NS37444-01A1) Post Doctoral Research
2003-2004
Cynthia and George Mitchell Awards in Dementia Research (PI: E.J. Weeber)
“The Relationship between APP and Apolipoprotein Receptors in Adult Hippocampal
Function”
7/03-6/05
American Federation for Aging Research
“The Role of ApoE Receptors in Hippocampal-Dependent Synaptic Function”
7/04-6/06
National Alliance for Research on Schizophrenia and Depression (NARSAD)
“Reelin-dependent alterations in Schizophrenia”
Current Support:
7/04-6/09
National Institutes on Aging 1 R01 AG022574-01 A1
“Mechanisms of Reelin signaling in the Adult Hippocampus”
Publications: 1-37
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A. M. Allan, E. J. Weeber, D. D. Savage, and K. K. Caldwell, "Effects of prenatal ethanol exposure
on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of
adult rat offspring," Alcohol Clin Exp Res 21(8), 1534-1541 (1997).
E. J. Weeber, C. M. Atkins, J. C. Selcher, A. W. Varga, B. Mirnikjoo, R. Paylor, M. Leitges, and J. D.
Sweatt, "A role for the beta isoform of protein kinase C in fear conditioning," J Neurosci 20(16),
5906-5914 (2000).
K. T. Dineley, E. J. Weeber, C. Atkins, J. P. Adams, A. E. Anderson, and J. D. Sweatt, "Leitmotifs in
the biochemistry of LTP induction: amplification, integration and coordination," J Neurochem 77(4),
961-971 (2001).
B. Mirnikjoo, S. E. Brown, H. F. Kim, L. B. Marangell, J. D. Sweatt, and E. J. Weeber, "Protein
kinase inhibition by omega-3 fatty acids," J Biol Chem 276(14), 10888-10896 (2001).
H. F. Seung Kim, E. J. Weeber, J. D. Sweatt, A. L. Stoll, and L. B. Marangell, "Inhibitory effects of
omega-3 fatty acids on protein kinase C activity in vitro," Mol Psychiatry 6(2), 246-248 (2001).
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E. J. Weeber, D. D. Savage, R. J. Sutherland, and K. K. Caldwell, "Fear conditioning-induced
alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal
formation and medial frontal cortex," Neurobiol Learn Mem 76(2), 151-182 (2001).
Y. Gu, K. L. McIlwain, E. J. Weeber, T. Yamagata, B. Xu, B. A. Antalffy, C. Reyes, L. Yuva-Paylor,
D. Armstrong, H. Zoghbi, J. D. Sweatt, R. Paylor, and D. L. Nelson, "Impaired conditioned fear and
enhanced long-term potentiation in Fmr2 knock-out mice," J Neurosci 22(7), 2753-2763 (2002).
J. M. Levenson, E. J. Weeber, J. D. Sweatt, and A. Eskin, "Glutamate uptake in synaptic plasticity:
from mollusc to mammal," Curr Mol Med 2(7), 593-603 (2002).
J. Levenson, E. Weeber, J. C. Selcher, L. S. Kategaya, J. D. Sweatt, and A. Eskin, "Long-term
potentiation and contextual fear conditioning increase neuronal glutamate uptake," Nat Neurosci
5(2), 155-161 (2002).
J. C. Selcher, E. J. Weeber, A. W. Varga, J. D. Sweatt, and M. Swank, "Protein kinase signal
transduction cascades in mammalian associative conditioning," Neuroscientist 8(2), 122-131
(2002).
K. Watase, E. J. Weeber, B. Xu, B. Antalffy, L. Yuva-Paylor, K. Hashimoto, M. Kano, R. Atkinson,
Y. Sun, D. L. Armstrong, J. D. Sweatt, H. T. Orr, R. Paylor, and H. Y. Zoghbi, "A long CAG repeat in
the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on
selective neurodegeneration," Neuron 34(6), 905-919 (2002).
E. J. Weeber, J. M. Levenson, and J. D. Sweatt, "Molecular genetics of human cognition," Mol
Interv 2(6), 376-391, 339 (2002).
E. J. Weeber, U. Beffert, C. Jones, J. M. Christian, E. Forster, J. D. Sweatt, and J. Herz, "Reelin
and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning," J Biol
Chem 277(42), 39944-39952 (2002).
E. J. Weeber, M. Levy, M. J. Sampson, K. Anflous, D. L. Armstrong, S. E. Brown, J. D. Sweatt, and
W. J. Craigen, "The role of mitochondrial porins and the permeability transition pore in learning and
synaptic plasticity," J Biol Chem 277(21), 18891-18897 (2002).
E. J. Weeber and J. D. Sweatt, "Molecular neurobiology of human cognition," Neuron 33(6), 845848 (2002).
C. S. Chan, E. J. Weeber, S. Kurup, J. D. Sweatt, and R. L. Davis, "Integrin requirement for
hippocampal synaptic plasticity and spatial memory," J Neurosci 23(18), 7107-7116 (2003).
T. J. Hendricks, D. V. Fyodorov, L. J. Wegman, N. B. Lelutiu, E. A. Pehek, B. Yamamoto, J. Silver,
E. J. Weeber, J. D. Sweatt, and E. S. Deneris, "Pet-1 ETS gene plays a critical role in 5-HT neuron
development and is required for normal anxiety-like and aggressive behavior," Neuron 37(2), 233247 (2003).
J. C. Selcher, E. J. Weeber, J. Christian, T. Nekrasova, G. E. Landreth, and J. D. Sweatt, "A role for
ERK MAP kinase in physiologic temporal integration in hippocampal area CA1," Learn Mem 10(1),
26-39 (2003).
J. D. Sweatt, E. J. Weeber, and P. J. Lombroso, "Genetics of childhood disorders: LI. Learning and
memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway," J Am Acad Child
Adolesc Psychiatry 42(6), 741-744 (2003).
J. D. Sweatt and E. J. Weeber, "Genetics of childhood disorders: LII. Learning and memory, part 5:
human cognitive disorders and the ras/ERK/CREB pathway," J Am Acad Child Adolesc
Psychiatry 42(7), 873-876 (2003).
E. J. Weeber, Y. H. Jiang, Y. Elgersma, A. W. Varga, Y. Carrasquillo, S. E. Brown, J. M. Christian,
B. Mirnikjoo, A. Silva, A. L. Beaudet, and J. D. Sweatt, "Derangements of hippocampal
calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation
syndrome," J Neurosci 23(7), 2634-2644 (2003).
S. Y. Yoo, M. E. Pennesi, E. J. Weeber, B. Xu, R. Atkinson, S. Chen, D. L. Armstrong, S. M. Wu, J.
D. Sweatt, and H. Y. Zoghbi, "SCA7 knockin mice model human SCA7 and reveal gradual
accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity," Neuron
37(3), 383-401 (2003).
U. Beffert, E. J. Weeber, G. Morfini, J. Ko, S. T. Brady, L. H. Tsai, J. D. Sweatt, and J. Herz, "Reelin
and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and
synaptic transmission," J Neurosci 24(8), 1897-1906 (2004).
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P. Marschang, J. Brich, E. J. Weeber, J. D. Sweatt, J. M. Shelton, J. A. Richardson, R. E. Hammer,
and J. Herz, "Normal development and fertility of knockout mice lacking the tumor suppressor gene
LRP1b suggest functional compensation by LRP1," Mol Cell Biol 24(9), 3782-3793 (2004).
P. May, A. Rohlmann, H. H. Bock, K. Zurhove, J. D. Marth, E. D. Schomburg, J. L. Noebels, U.
Beffert, J. D. Sweatt, E. J. Weeber, and J. Herz, "Neuronal LRP1 functionally associates with
postsynaptic proteins and is required for normal motor function in mice," Mol Cell Biol 24(20),
8872-8883 (2004).
P. Opal, J. J. Garcia, A. E. McCall, B. Xu, E. J. Weeber, J. D. Sweatt, H. T. Orr, and H. Y. Zoghbi,
"Generation and characterization of LANP/pp32 null mice," Mol Cell Biol 24(8), 3140-3149 (2004).
V. Strasser, D. Fasching, C. Hauser, H. Mayer, H. H. Bock, T. Hiesberger, J. Herz, E. J. Weeber, J.
D. Sweatt, A. Pramatarova, B. Howell, W. J. Schneider, and J. Nimpf, "Receptor clustering is
involved in Reelin signaling," Mol Cell Biol 24(3), 1378-1386 (2004).
E. J. Weeber and K. K. Caldwell, "Delay fear conditioning modifies phospholipase C-beta 1a
signaling in the hippocampus and frontal cortex," Pharmacol Biochem Behav 78(1), 155-164
(2004).
U. Beffert, E. J. Weeber, A. Durudas, S. Qiu, I. Masiulis, J. D. Sweatt, W. P. Li, G. Adelmann, M.
Frotscher, R. E. Hammer, and J. Herz, "Modulation of synaptic plasticity and memory by Reelin
involves differential splicing of the lipoprotein receptor Apoer2," Neuron 47(4), 567-579 (2005).
M. Sinagra, D. Verrier, D. Frankova, K. M. Korwek, J. Blahos, E. J. Weeber, O. J. Manzoni, and P.
Chavis, "Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control
somatic NMDA receptor composition during hippocampal maturation in vitro," J Neurosci 25(26),
6127-6136 (2005).
U. Beffert, A. Durudas, E. J. Weeber, P. C. Stolt, K. M. Giehl, J. D. Sweatt, R. E. Hammer, and J.
Herz, "Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor
binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity," J
Neurosci 26(7), 2041-2052 (2006).
C. S. Chan, E. J. Weeber, L. Zong, E. Fuchs, J. D. Sweatt, and R. L. Davis, "Beta 1-integrins are
required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and
working memory," J Neurosci 26(1), 223-232 (2006).
I. Nishijima, T. Yamagata, C. M. Spencer, E. J. Weeber, O. Alekseyenko, J. D. Sweatt, M. Y.
Momoi, M. Ito, D. L. Armstrong, D. L. Nelson, R. Paylor, and A. Bradley, "Secretin receptor-deficient
mice exhibit impaired synaptic plasticity and social behavior," Hum Mol Genet 15(21), 3241-3250
(2006).
M. M. Peters, K. E. Hill, R. F. Burk, and E. J. Weeber, "Altered hippocampus synaptic function in
selenoprotein P deficient mice," Mol Neurodegener 1, 12 (2006).
S. Qiu, K. M. Korwek, A. R. Pratt-Davis, M. Peters, M. Y. Bergman, and E. J. Weeber, "Cognitive
disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice," Neurobiol
Learn Mem 85(3), 228-242 (2006).
S. Qiu, K. M. Korwek, and E. J. Weeber, "A fresh look at an ancient receptor family: emerging roles
for low density lipoprotein receptors in synaptic plasticity and memory formation," Neurobiol Learn
Mem 85(1), 16-29 (2006).
G. W. Rebeck, M. J. Ladu, S. Estus, G. Bu, and E. J. Weeber, "The generation and function of
soluble apoE receptors in the CNS," Mol Neurodegener 1, 15 (2006).
F. Bolognani, S. Qiu, D. Tanner, J. Paik, N. I. Perrone-Bizzozero, E. J. Weeber. Associative and
spatial learning deficits in transgenic mice over-expressing the RNA-binding protein HuD. (2006) (In
Press) Neurobiol of Learn and Mem
Shenfeng Qiu, Liying Li, Edwin J. Weeber and James M. May. Ascorbate transport by primary
cultured neurons and its role in neuronal function and protection against excitotoxicity. (2006) (In
Press) J Neurosci Res
S. Qiu, L. F. Zhao, K. M. Korwek, E. J. Weeber. Differential coupling with enhanced NMDA and
AMPA receptor activity by reelin signaling in the adult hippocampus. (2006) (In Press) J Neurosci
Accepted with Revision:
1. G. M. van Woerden, K. D. Harris, M. R. Hojjati, R. M. Gustin, R. de Avila Freire, Y. H. Jiang, Y.
Elgersma, E. J. Weeber. Rescue of neurological deficits in a mouse model for Angelman Syndrome
by reduction of CaMKII inhibitory phosphorylation. (Accepted with revision) Nature Neuroscience
2. S. Qiu and E. J. Weeber. Reelin signaling facilitates maturation of CA1 glutamatergic synapses
(Accepted with revision) J Neurophys.
Submitted:
1. J. N. Gelinas, J. L. Banko, L. Hou, T. Abel, N. Sonenberg, E. J. Weeber, E. Klann and P. V.
Nguyen. ERK and mTOR signaling couple ß-adrenergic receptors to translation initiation to gate
induction of protein synthesis-dependent LTP. (Submitted to J Neurosci)
2. L. Zhou, S. Qiu, K. M. Korwek, R. Gustin, M. Peters and E. J. Weeber. Supplemental Reelin
Rescues the Cognitive Defects in the Heterozygote Reeler Mouse. (Submitted to J Neurosci)
Book Chapters:
E. J. Weeber and J. David Sweatt
“Disruptions of signal transduction pathways in mental retardation: Angelman and Coffin-Lowry
syndrome”, In: Recent Research Developments in Neurochemistry, Vol. 3 Part II. S.G. Pandalai, ed.
Research Signpost, Kerala, India (2000)
J. C. Selcher, E. J. Weeber, and J. D. Sweatt
“MAP kinases”, In: From Messengers to Molecules: Memories are Made of These G. Riedel and
B. Platt, ISBN: 0-306-47862-5. Landes Bioscience, Georgetown, TX. (2004)
L. Schrader, E. J. Weeber, C. Atkins and J. D. Sweatt
“The Role of Protein Kinase C in Mammalian Synaptic Plasticity, Learning and Memory”, In: Protein
Kinase C. L. Dekker, eds. Landes Bioscience, Georgetown, TX (2004)
J. L. Banko and E. J. Weeber
“Angelman Syndrome”, In: "Learning and Memory: A Comprehensive Reference" Elsevier LTD.
Oxford, UK (2006)
S. Qiu and E. J. Weeber
“Reelin and Cognition”, In: "Reelin Glycoprotein, biology, structure and roles in health and disease."
Elsevier LTD. Oxford, UK (2006)