CURRICULUM VITAE Natalie M. Zahr, Ph.D. Stanford, CA, USA

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CURRICULUM VITAE
Natalie M. Zahr, Ph.D.
Stanford, CA, USA
[email protected]
Education:
2005
Ph.D. in Anatomy and Neurobiology
Boston University, Boston
2001
M.S. in Pharmacology
Northeastern University, Boston
1997
B.A. in Philosophy
University of California, Los Angeles
Research Positions:
2013 - present
Senior Scientist, Neuroscience Program
SRI International, Menlo Park, CA
2008 - present
Research Scientist, Department of Psychiatry & Behavioral Sciences
Stanford University, Stanford, CA
2007 - 2013
Postdoctoral Fellow, Neuroscience Program
Advisor: Dr. Adolf Pfefferbaum
2005 - 2008
Postdoctoral Fellow, Department of Psychiatry & Behavioral Sciences
Advisor: Dr. Edith Sullivan
2003 - 2005
Visiting Scholar, Physiology Department
Northwestern University, Chicago, IL
Advisor: Dr. Isabelle Mintz
2001 - 2003
Graduate Student, Anatomy and Neurobiology Department
Boston University, Boston, MA
Advisor: Dr. Isabelle Mintz
1998 - 2001
Graduate Student, Pharmaceutical Sciences Department
Northeastern University, Boston, MA
Advisor: Dr. Barbara Waszczak
Teaching Positions (selected):
Summer 2012/2013 Instructor, Neuroscience
UC Berkeley Extension
UC Berkeley, Berkeley, CA
Winter 2012
Instructor, Human Anatomy
UC Berkeley Extension
UC Berkeley, Berkeley, CA
Spring 2001
Teaching Assistant, Therapeutics I and II
Department of Pharmaceutical Sciences
Spring 2000
Teaching Assistant, Anatomy and Physiology
Winter 2000
Teaching Assistant, Immunology
1
NIH Funding
Multiple-investigator
U01 AA017347
09/01/12 – 08/31/17
Tracking HIV Infection and Alcohol Abuse CNS Comorbidity with Neuroimaging
MPI: Adolf Pfefferbaum & Natalie M. Zahr
National Institute on Alcohol Abuse and Alcoholism
Co-investigator
U01 AA013521
12/01/10 – 09/30/15
Integrative Neuroscience Initiative on Alcoholism: Imaging Core
PI: Adolf Pfefferbaum
Other Funding
R01 AA005965
06/01/07 – 06/30/12
CNS Deficits: Interaction of Age and Alcoholism
PI: Adolf Pfefferbaum
R01 AA012388
02/15/11 – 01/31/16
Neuroimaging of Connectivity in Alcoholism
MPI: Adolf Pfefferbaum & Edith V. Sullivan
National Institute of Alcohol Abuse and Alcoholism
U01 AA013521
02/15/07 – 06/30/08
Effects of Acute Alcohol Exposure on Rat Brain Metabolites Detected In Vivo Using MRS
Integrative Neuroscience Initiative on Alcoholism
PI: Dirk Mayer
Pilot Grant
SRI International Research and Development Awards
W32JUN
2010
Systemic evidence for inflammatory mechanisms in ethanol induced neurodegeneration
W32KTS
2009
ALDA Effects on Ethanol Metabolism
W32NBW
2011
In vivo MR markers of inflammation
Professional Associations
Society for Neuroscience
Research Society on Alcoholism
International Society on Magnetic Resonance in Medicine
Society for Neuroimmune Pharmacology
Peer-Reviewed Papers
Sullivan EV, Zahr NM, Rohlfing T, Pfefferbaum A. Cognitive demands during quiet standing elicit
truncal tremor in two frequency bands: Differential relations to tissue integrity of corticospinal tracts
and cortical targets. Frontiers in Human Neuroscience in revision.
Pfefferbaum A, Zahr NM, Mayer D, Rohlfing T, Sullivan EV. Rapid recovery from fiber tract
disorganization following a 4-day alcohol binge. PlosOne in revision.
Pfefferbaum A, Rosenbloom MJ, Chu W, Sassoon SA, Rohlfing T, Pohl KM, Zahr NM, Sullivan EV. 2
White matter microstructural recovery with abstinence and decline with relapse in alcoholism:
A controlled longitudinal DTI study. Lancet Neurology. 2014. 1(3):202-212.
Zahr NM, Alt C, Mayer D, Rohlfing T, Manning-Bog A, Luong R, Sullivan EV, Pfefferbaum A. In vivo
MRI, MRS, and postmortem regional brain cytokine histochemistry biomarkers in a rodent model of
Wernicke's Encephalopathy with glucose challenge. Experimental Neurology. 2014. 261:109-19.
Pfefferbaum A, Ragosa DA, Rosenbloom MJ, Chu WW, Sassoon, SA, Kemper CA, Deresinski S,
Rohlfing T, Zahr NM, Sullivan EV. Accelerated aging of selective brain structures in HIV Infection: A
controlled, longitudinal MRI study. Neurobiology of Aging. 2014. 35(7):1755-68.
Zahr NM, Mayer D, Rohfling T, Sullivan EV, Pfefferbaum A. Imaging neuroinflammation?
A perspective from MR Spectroscopy. Brain Pathology. 2014. 24(6): 654-64.
Zahr NM. Graphs of Brain Networks. Commentary for “The effects of alcohol on the nonhuman
primate brain: A network science approach to neuroimaging.” Alcohol Clinical and Experimental
Research. 2013. 37(11): 1813-5.
Zahr NM, Mayer D, Rohlfing T, Hsu OA, Vinco S, Orduna J, Luong R, Bell RL, Sullivan EV,
Pfefferbaum A. Rat strain differences in brain structure and neurochemistry in response to binge
alcohol. Psychopharmacology. 2014. 231(2): 429-45.
Zahr NM, Mayer D, Rohlfing T, Orduna J, Luong R, Sullivan EV, Pfefferbaum A. A mechanism of
rapidly reversible cerebral ventricular enlargement independent of tissue atrophy.
Neuropsychopharmacology. 2013. 38(6): 1121-9.
Zahr NM, Mayer D, Rohlfing T, Chanraud S, Gu M, Sullivan EV, Pfefferbaum A. The functional
significance of an in vivo glutamate measure derived from Magnetic Resonance Spectroscopy:
behavioral and physiological correlates in aging. Neurobiology of Aging. 2013. 34(4): 1265.76.
Gu M, Zahr NM, Spielman D, Sullivan EV, Pfefferbaum A, Mayer D. Quantification of glutamate and
glutamine using CT-PRESS at 3T. NMR in Biomedicine. 2013. 26(2): 164-72.
Zahr NM, Harper CG, Kaufman KL. Clinical and pathological features of alcohol-related brain damage.
Nature Reviews Neurology. 2011. 7(5): 284-94.
Zahr NM, Bell RL, Ringham HN, Sullivan EV, Witzmann FA, Pfefferbaum A. Ethanol-induced changes
in the expression of proteins related to neurotransmission and metabolism in different regions of the
rat brain. Pharmacology, Biochemistry, and Behavior. 2011. 99(3): 428-36.
Sullivan EV, Zahr NM, Rohlfing T, Pfefferbaum A. Fiber tracking functionally distinct components of
the internal capsule. Neuropsychologia. 2010. 48(14): 4155-63.
Pitel AL, Zahr NM, Jackson K, Sassoon SA, Rosenbloom MJ, Pfefferbaum A, Sullivan EV.
Signs of preclinical Wernicke's Encephalopathy and thiamine levels as predictors of
neuropsychological deficits in alcoholism without Korsakoff's Syndrome. Neuropsychopharmacology.
2011. 36(3): 580-8.
Zahr NM, Pitel AL, Chanraud S, Sullivan EV. Contributions of studies on alcohol use disorders
to understanding cerebellar function. Neuropsychology Reviews. 2010. 20(3): 280-9.
Zahr NM, Luong R, Sullivan EV, Pfefferbaum A. Measurement of serum, liver, and brain cytokine
induction, thiamine Levels, and hepatopathology in rats exposed to a 4-Day binge protocol. Alcohol
Clinical and Experimental Research. 2010. 34(11): 1-13.
Zahr NM, Mayer D, Rohlfing T, Hasak M, Hsu O, Vinco S, Orduna J, Luong R, Sullivan EV,
Pfefferbaum A. Brain injury and recovery following binge ethanol: evidence from in vivo magnetic
resonance spectroscopy. Biological Psychiatry. 2010. 67(9): 846-54.
Chanraud S, Zahr NM, Sullivan EV, Pfefferbaum A. MR Diffusion Tensor Imaging: A window into
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white matter integrity of the working brain. Neuropsychology Reviews. 2010. 20(2): 209-25.
Rohlfing T, Zahr NM, Sullivan EV, Pfefferbaum A. The SRI24 multi-channel atlas of normal adult human
brain structure. Human Brain Mapping. 2010. 31(5): 798-819.
Zahr NM, Crawford EL, Hsu O, Vinco S, Mayer D, Rohlfing T, Sullivan EV, Pfefferbaum A. In vivo
glutamate decline associated with kainic-acid induced status epilepticus. Brain Research. 2009.
1300: 65-78.
Rohlfing T, Zahr NM, Sullivan EV, Pfefferbaum A. The SRI24 multi-channel brain atlas: construction and
applications. Medical Imaging 2008: Image Processing, Reinhardt JM and Pluim JPW. Eds., Bellingham,
WA, 2008, vol. 6914 of Proceedings of SPIE, 691409.
Zahr NM, Rohlfing T, Pfefferbaum A, Sullivan EV. Problem solving, working memory, and motor
correlates of association and commissural fiber bundles in normal aging: A quantitative fiber tracking
study. NeuroImage. 2009. 44(3): 1050-62.
Zahr NM, Sullivan EV. Translational studies of alcoholism: Bridging the gap. Alcohol Research and
Health. 2008. 31(3): 215-30.
Pfefferbaum, A, Zahr NM, Mayer D, Vinco S, Orduna J, Rohlfing T, Sullivan EV. Ventricular expansion in
wild-type Wistar rats after alcohol exposure by vapor chamber. Alcohol Clinical and Experimental
Research. 2008. 32(8): 1459-67.
Zahr NM, Mayer D, Vinco S, Orduna J, Luong R, Sullivan EV, Pfefferbaum A. In vivo evidence for alcoholinduced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine
deficiency, or severe liver damage. Neuropsychopharmacology. 2009. 34(6): 1427-42.
Sullivan EV, Zahr, NM. Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on
“Increased MCP-1 and microglia in various regions of human alcoholic brain.” Experimental Neurology.
2008. 213(1): 10-17.
Zahr NM, Mayer D, Pfefferbaum A, Sullivan EV. Low striatal glutamate levels underlie cognitive decline in
the elderly: Evidence from in vivo molecular spectroscopy. Cerebral Cortex. 2008. 18(10): 2241-50.
Mayer D, Zahr NM, Sullivan EV, Pfefferbaum A. In vivo metabolite differences between the basal ganglia
and cerebellum of the rat brain detected with proton MRS at 3T. Psychiatry Research: Neuroimaging.
2007. 154(2): 267-73.
Mayer D, Zahr NM, Sullivan EV, Pfefferbaum A. In vivo fiber tracking in the rat brain on a clinical 3T MRI
system using a high strength insert gradient coil. NeuroImage. 2007. 35(3): 1077-85.
Zahr NM, Martin LP, Waszczak BL. Subthalamic nucleus lesions alter basal and dopamine agonist
stimulated electrophysiological output from the rat basal ganglia. Synapse. 2004. 54(2): 119-28.
Waszczak BL, Martin LP, Finlay HE, Zahr N, Stellar JR. Effects of individual and concurrent stimulation of
striatal D1 and D2 dopamine receptors on electrophysiological and behavioral output from the rat basal
ganglia. Journal of Pharmacology and Experimental Therapeutics. 2002. 300(3): 850-61.
Waszczak BL, Martin LP, Boucher N, Zahr N, Sikes RW, Stellar JR. Electrophysiological and behavioral
output of the rat basal ganglia after intrastriatal infusion of d-amphetamine: lack of support for the basal
ganglia model. Brain Research. 2001. 920(1-2): 170-82.
Book Chapters
Zahr NM. Chapter 6: Structural and Microstructural Imaging of the Brain in Alcohol Use Disorders.
Handbook of Clinical Neurology. Sullivan EV, Pfefferbaum A (eds). 2014.
Zahr NM, Manning-Bog A, Alt C, Sullivan EV, Pfefferbaum A. Immune Responses in HIV Infection,
Alcoholism, and Aging: A Neuroimaging Perspective. Cui C, Grandison L, Noronha A (eds). Springer.
2012.
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Zahr NM, Lough ME, Jung YC, Sullivan EV. Measurement of thiamine levels in human tissue. Food
and Nutritional Components in Focus, B Vitamins. Preedy VR (ed). Royal Society of Chemistry
Publishing. 2012.
Zahr NM, Pfefferbaum A, Sullivan EV. Chapter 4: Changes in the macrostructure and microstructure
of the aging brain. Principles and Practice of Geriatric Psychiatry, 3rd Edition. Abou-Saleh M, Katona
C, Kumar A (eds). Wiley-Blackwell. 2010.
Abstracts
Zahr NM, Fama R, Rohlfing T, Sullivan EV, Pfefferbaum A. Neural Correlates of Cognitive Deficits in
HIV Infection. Society on NeuroImmune Pharmacology (2015).
Zahr NM, Sullivan EV, Pfefferbaum A. In Vivo MR Imaging Evidence for Variable CNS Responses to
Repeated Binge Ethanol Treatment. American College of Neuropsychopharmacology (2014).
Zahr NM, Colrain I, Sullivan EV, Pfefferbaum A. Brain Recovery in Sober Alcoholics. Pan Arabian
Psychiatric Conference (2014).
Zahr NM, Saranthan MK, Carr RA, Collins AM, Rohlfing T, Mayer D, Sullivan EV, Colrain IM,
Pfefferbaum A. Brain metabolite levels as predictors of abstinence or relapse in alcohol use
disorders. Society for Neuroscience (2014).
Zahr NM, Sullivan EV, Pfefferbaum A. In vivo diffusion tensor imaging evidence for reversible white
matter microstructural integrity disruption: effects of abstinence in rat and man. Research Society on
Alcoholism (2014).
Zahr NM. Translational studies using in vivo neuroimaging: from rats to man. Gordon Research
Conference (2014).
Zahr NM, Sullivan EV, Pfefferbaum A. Neuroimaging of HIV and Alcoholism: Perspectives from Blood
Markers. International Society for NeuroVirology (2013)
Zahr NM, Sullivan EV, Pfefferbaum A. In vivo diffusion tensor imaging evidence for reversible white
matter microstructural integrity disruption with binge but not chronic ethanol exposure. American
College of Neuropsychopharmacology (2013)
Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Influence of hepatitis C status on brain metabolites:
evidence for neuroinflammation in HIV infected patients. Society for Neuroscience (2013)
Zahr NM, Sullivan EV, Pfefferbaum A. Models of alcoholism and common concomitants of alcoholism:
differentiating pathological mechanisms. Research Society on Alcoholism (2013)
Zahr NM. Effects of Chronic Alcohol Consumption on Neurochemicals and Brain Energy. 3rd
International Conference on Applications of Neuroimaging to Alcoholism (2013)
Zahr NM, Sullivan EV, Pfefferbaum A. Translational neuroimaging studies: from rats to man
American College of Neuropsychopharmacology (2012)
Zahr NM, Sullivan EV, Pfefferbaum A. A mechanism of ventricular enlargement in an alcohol binge
model. American College of Neuropsychopharmacology (2012)
Zahr NM, Pfefferbaum A, Sullivan EV. The effects of body mass index on magnetic resonance
spectroscopy brain metabolite measurements. Society for Neuroscience (2012)
Alt C, Manning-Bog A, Sullivan EV, Pfefferbaum A, Zahr NM. Evidence for neuroinflammation in the
thiamine deficient rat. Society for Neuroscience (2012)
Zahr NM, Pfefferbaum A, Sullivan EV. Alcohol exposure and nutritional deficiency in rat models:
translational neuroimaging studies. Society for Neuroscience (2012)
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Pfefferbaum A, Zahr NM, Sullivan EV. Translational neuroimaging studies: from rats to man.
American College of Neuropsychopharmacology (2012)
Zahr NM, Mayer D, Gu M, Orduna J, Alt C, Manning-Bog A, Sullivan E, Pfefferbaum A.
CNS immune response in rats with liver damage. Research Society on Alcoholism (2012)
Zahr NM, Mayer D, Gu M, Rohlfing T, Sullivan EV, Pfefferbaum A. Neuroradiological signatures of
thiamine deficiency and glucose loading in the rat revealed with MRI and MRS at 3T. Society for
Neuroscience (2011)
Zahr NM, Mayer D, Hsu O, Vinco S, Orduna J, Bell RL, Sullivan EV, Pfefferbaum A.
A comparison of in vivo neurochemical sequelae of binge alcohol exposure in wild type Wistar,
alcohol preferring, and alcohol nonpreferring rats. Research Society on Alcoholism (2011)
Pfefferbaum A, Sullivan EV, Zahr NM. Alcohol exposure and nutritional deficiency in rat models:
translational neuroimaging studies. Alcoholism and Stress Conference (2011)
Zahr NM, Chen C-H, Mayer D, Mochly-Rosen D, Sullivan EV, Pfefferbaum A. The effects of an
aldehyde dehydrogenase activator on blood ethanol levels in mice and brain ethanol kinetics in rats.
Society for Neuroscience (2010)
Sullivan EV, Zahr NM, Rohlfing T, Pfefferbaum A. Cognitive demands elicit tremor during quiet
standing in alcoholics: Relation to tissue integrity of brain systems contributing to sensorimotor
integration. Society for Neuroscience (2010)
Zahr NM, Mayer D, Gu M, Sullivan EV, Pfefferbaum A. In Vivo Translational Study of Brain Glutamate
in Aging and Alcoholism. American College of Neuropsychopharmacology (2010)
Pfefferbaum A, Sullivan EV, Zahr NM. Neuroadaptation to Alcohol Exposure in Humans and Animal
Models. Platform presentation at the International Behavioral Neuroscience Society meeting (2010)
Zahr NM, Luong R, Sullivan EV, Pfefferbaum A. Binge Ethanol Treatment Is Insufficient to Elevate
Cytokine Levels Measured in Rat Blood, Liver, and Brain. Research Society on Alcoholism (2010)
Zahr NM, Gu M, Mayer D, Speilman DM, Sullivan EV, Pfefferbaum A. Glutamate and Glutamine
Changes Induced by Ethanol Treatment in the Rat Brain Detectable with CT-PRESS at 3T.
International Society of Magnetic Resonance in Medicine (2010)
Gu M, Zahr NM, Speilman DM, Sullivan EV, Pfefferbaum A. Mayer D. Quantification of Glutamate and
Glutamine using CT-PRESS at 3T. International Society of Magnetic Resonance in Medicine (2010)
Zahr NM, Chanraud S, Mayer D, Sullivan EV, Pfefferbaum A. Neurochemical profiles of the human
basal ganglia, cerebellum, and pons as influenced by age. Society for Neuroscience (2009)
Zahr NM, Mayer D, Hsu O, Vinco S, Orduna J, Sullivan EV, Pfefferbaum A. In Vivo Neurochemical
Evidence for Alcohol Binge Induced Neural Compromise and Recovery in Alcohol-Preferring Rats.
Research Society on Alcoholism (2009)
Zahr NM, Mayer D, Rohlfing T, Hasak M, Hsu O, Vinco S, Orduna J, Sullivan EV, Pfefferbaum A. Binge
Ethanol Induced Structural and Neurochemical Changes in the Rat Brain Detectable at 3T. International
Society of Magnetic Resonance in Medicine (2009)
Zahr NM, Crawford E, Hsu O, Vinco, S, Mayer D, Rohlfing T, Sullivan EV, Pfefferbaum A. Kainic acid
seizures produce ventral hippocampal damage detectable with MRI and dorsal hippocampal damage
followed by recovery detectable with serial MRS. Society for Neuroscience (2008)
Zahr NM, Mayer D, Vinco S, Orduna J, Sullivan EV, Pfefferbaum A. Long-term alcohol exposure by
vapor chamber alters MRS detectable metabolites in rat striatum. Research Society on Alcoholism.
Symposium platform presentation (2008)
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Zahr NM, Rohfling T, Pfefferbaum A, Sullivan EV. Quantitative fiber tracking in the normal aging
brain: neuropsychological correlates. International Society of Magnetic Resonance in Medicine
(2008)
Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Basal Ganglia, cerebellum and pons detected in vivo
with MR Spectroscopy: Aging and behavioral correlates. Society for Neuroscience (2007)
Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Differential effects of age on tissue water-referenced
proton metabolites in basal ganglia, cerebellum and pons using an MRS sequence optimized for
glutamate detection. International Society of Magnetic Resonance in Medicine (2007)
Mayer D, Zahr NM, Sullivan EV, Pfefferbaum A. Differences in rat cerebellar and striatal metabolite
ratios detected in vivo with optimized CT-PRESS. International Society of Magnetic Resonance in
Medicine (2007)
Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Differences in rat cerebellar and striatal metabolite
ratios detected in vivo with optimized CT-PRESS. Society for Neuroscience (2006)
Mayer D, Adalsteinsson E, Rutt B, Zahr NM, Sullivan EV, Pfefferbaum A. In vivo diffusion tensor
imaging of rat brain acquired with a 3T clinical MRI system and a high strength insert gradient coil.
International Society of Magnetic Resonance in Medicine (2006)
Zahr NM, Martin LP, Collins HA, Tran TH, Waszczak BL. Subthalamic nucleus lesions alter basal and
agonist-stimulated electrophysiological output from the rat basal ganglia. ASBMB/ASPET (2000)
Zahr NM, Martin LP, Collins HA, Tran TH, Freedman JE, and Waszczak BL. Subthalamic nucleus
lesions alter basal and agonist-stimulated electrophysiological output from the rat basal ganglia.
Society for Neuroscience (1999)
Outreach
2011 The Sequoia Center, Redwood City
2012 The Sequoia Center, Redwood City
2013 Mills Hospital Chemical Dependency Center Alumni
2014 Mills Hospital Chemical Dependency Center Alumni
Awards
1999 Travel Award
2000 Poster Presentation Award
2001 Neumeyer Research Scholarship Award
2007 Educational Stipend Award
2007 NIH Loan Repayment Program
2008 SRI Postdoctoral Fellowship Award
2008 RSA Junior Investigator Meeting Award
2008 RSA Gordis Research Recognition Award
2008 Women in Neuroscience Postdoc. Award
2008 SRI Spot Award / Outstanding Employee
2009 NIH Loan Repayment Program - Renewal
2009 Educational Stipend Award
2010 ACNP Invited Panel Speaker
2012 ACNP Invited Panel Speaker
2013 ICANA Invited Speaker
2013 McLean Imaging Center Invited Speaker
2013 ACNP Travel Award
2013 ACNP Poster Award
2014 Invited Speaker
Gordon Research Conference, Oxford, UK
New England Pharmacologists, Providence, RI
ISMRM, Berlin, GE
Research Society on Alcoholism, Washington, DC
Research Society on Alcoholism, Washington, DC
Society for Neuroscience, Washington, DC
ISMRM, Honolulu, HA
ACNP, North Hollywood, FL
ICANA, Yale, CT
Harvard Medical School, Belmont, MA
Gordon Research Conference, Galvasten, TX
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References
Edith V. Sullivan, Ph.D.
Psychiatry and Behavioral Sciences
Stanford University
401 Quarry Rd. Stanford, CA 94305
(650) 859-2880
[email protected]
Adolf Pfefferbaum, M.D.
Neuroscience Department
SRI International
333 Ravenswood Ave. Menlo Park, CA 94025
(650) 859-2927
[email protected]
Mark Moss, Ph.D.
Anatomy and Neurobiology
Boston University School of Medicine
715 Albany St Boston, MA 02115 t
(617) 638-4200
[email protected]
Deborah Vaughn, Ph.D.
Anatomy and Neurobiology
Boston University School of Medicine
715 Albany St Boston, MA 02115
(617) 638-5311
[email protected]
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CURRICULUM VITAE Natalie M. Zahr, Ph.D. Stanford, CA, USA

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