Summer 2016 news - Institute of Structural Molecular Biology

ISMB NEWS
Issue 12, Summer 2016
ISMB NEWS is a news bulletin published in order to share information between the various departments involved
in the Institute of Structural and Molecular Biology. This includes information such as events, research highlights,
new staff appointments, awards and grants.
Your comments, suggestions and contributions are welcome and will help us put together a newsletter which
meets your expectations. Please email the ISMB administrator at [email protected].
In this issue
WELCOME TO… FAREWELL TO…
1
IN FOCUS: ISMB PROFILES
Dr Anthony Roberts and Dr Giulia Zanetti
2
RESEARCH HIGHLIGHTS
ISMB Featured articles and commentaries
3
STUDENT NEWS
5
UPDATE ON CENTRES &
LABORATORIES
5
AWARDS, PRIZES & GRANTS
8
UPCOMING EVENTS
10
A 3D NMR restrained structural ensemble of folded FLN5 as
tethered to the ribosome, showing that a number of key
interactions between the nascent chain and the ribosome exist
at the ribosomal exit
(Cabrita LD, Cassaignau AME, Launay HMM, Waudby CA, Wlodarski T,
Camilloni C, Karyadi M, Robertson AL, Wang X, Wentink AS, Goodsell
LS, Woolhead CA, Vendruscolo M, Dobson CM, Christodoulou J. A
structural ensemble of a ribosome–nascent chain complex during
cotranslational protein folding. Nature Structural & Molecular Biology
23, 278–285 (2016) doi:10.1038/nsmb.3182
WELCOME TO… FAREWELL TO…
Welcome to the following Post-Doctoral Research Associates who have recently joined ISMB lab groups:
Dr Claire Naylor and Dr Vicky Hale, who join the EM and Image Processing group; Dr Yongzheng Xing and
Dr Jonathan Burns who join Dr Stefan Howorka’s lab group; Dr Agnel Praveen Joseph who joins Dr Maya
Topf’s group and Dr Chris Cozens, Dr Warren Hazelton and Dr Ana Riesco who join Vitor Pinheiro’s group.
Welcome also to Dr Angelo Figueiredo, the ISMB’s NMR facility manager (following Dr John Kirkpatrick) and Dr
Natasha Lukoyanova, formerly an EM group post-doc and now EM Facility Coordinator (following Dr Luchun
Wang).
Welcome also to the following PhD students:
Hyunah Lee (Dr Tracey Barrett’s group), Shaan Subramaniam (Dr Emmanuel Boucrot’s group), Leonor
Quintaneiro (Dr Filipe Cabreiro’s group), Jianxiong Zhao (Prof Helen Hailes’ group), Joanna Donelly and
Patrick Arnott (Dr Stefan Howorka’s group), Alex Cook and Fiona Shilliday (Prof Carolyn Moores’ group),
Hugo Villanueva (Dr Renos Savva’s group) and Sarah Jones, who joins Dr Jo Santini’s group with joint
supervision by Dr Karen Hudson-Edwards in Birkbeck’s Department of Earth and Planetary Sciences.
Farewell to the following Post-Docs:
Dr Nicolas Werbeck recently left Dr Flemming Hansen’s group after 5 years and 3 months to take up a position
as group leader at Bayer Pharmaceuticals in Berlin. Farewell to Dr Julia Wenger, who has departed Prof Carolyn
Moores’ group and joined the Francis Crick Institute. Farewell also to ‘Science Without Borders’ post-doc Dr
Geancarlo Zanetta, who has left Prof Bonnie Wallace’s group; to Dr Ana Mendes Pereira who recently left
Emmanuel Boucrot’s group after 3.5 years as a BBSRC funded post-doc, and to Dr Thomas Warelow, who has
left Prof Peter Rich’s group.
Page 1
ISMB NEWS – Issue 12 – Summer 2016
IN FOCUS: ISMB PROFILES
Dr Anthony Roberts
Anthony joined the ISMB as a Sir Henry Dale Fellow in November 2014. His
research is centred on how cytoskeletal motor proteins create movement and
spatial organization within eukaryotic cells. A main focus is on dynein, a large but
poorly understood motor protein that uses ATP hydrolysis to transport cellular
components and signals along microtubules.
Anthony read Biochemistry as an undergraduate at Imperial College, followed by
PhD studies with Professor Peter Knight and Dr Stan Burgess on the 4-year
Wellcome Trust program at the University of Leeds. His thesis project investigated
dynein's ATP-driven conformational changes using electron microscopy, involving a close collaboration with
Professor Kazuo Sutoh’s group at the University of Tokyo where Anthony was fortunate to receive
specialist training in dynein biochemistry via a BBSRC Japan Partnering Award.
As a Sir Henry Wellcome Postdoctoral Fellow, Anthony investigated how dynein is regulated in time and
space, mentored by Professor Samara Reck-Peterson at Harvard Medical School. During these studies, he
developed a strong interest in how single-molecule studies could be combined with structural insights from
electron microscopy. As part of his fellowship, he also trained with a professional molecular
animator, Dr Janet Iwasa, and developed an animated model of how dynein’s motor domain generates
movement.
At the ISMB, Anthony’s group is using multi-protein expression in insect cells, TIRF and electron microscopy
to ask mechanistic questions about dynein's action and regulation. An additional interest is how dynein
operates with the other class of microtubule motor, kinesin.
[Details of work, papers and animations at http://people.cryst.bbk.ac.uk/~ubcg87a/]
[email: [email protected]]
Dr Anthony Roberts
Dr Giulia Zanetti
Giulia Zanetti is a research fellow and lecturer at the ISMB.
Her lab uses a combination of biochemistry and cryo-electron microscopy to answer
outstanding questions in the field of protein secretion, with particular emphasis on
eukaryotic secretory pathways and the mechanisms of intracellular transport of
medically important giant cargoes.
Eukaryotic cells are organised in membrane-bound compartments that constantly and
actively exchange material. Coat complexes promote transport of proteins between
compartments by generating cargo-loaded membrane vesicles. Tight regulation of traffic ensures that each
class of protein is delivered to the right place at the right time, so that cells can function smoothly and
communicate with each other. The first step in trafficking, cargo exit from the endoplasmic reticulum (ER), is
mediated by the COPII coat. The mechanisms of COPII transport of large cargoes, for example extracellular
matrix components such as procollagens, and bulky lipoproteins such as pre-chylomicrons, are still poorly
understood. Giulia’s lab aims to reveal how COPII function is regulated to promote secretion of very large
molecules, and how defects in such mechanisms lead to disease in humans.
Giulia obtained her PhD in 2009 from Steve Fuller’s laboratory at the University of Oxford, where she
pioneered the use of cryo-tomography and sub-tomogram averaging to solve protein structure in situ. She
has continued to develop this methodology during her EMBO and HFSP-funded postdoc in Randy Schekman
lab at UC Berkeley, looking at coat protein structure. She has also developed an expertise in single-particle
cryo-EM working on a bacterial secretion system with Gabriel Waksman at ISMB. She is currently a Royal
Society Dorothy Hodgkin research fellow.
[Details of work and papers at http://people.cryst.bbk.ac.uk/~ubgzan01/]
[email: [email protected]]
Dr Giulia Zanetti
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ISMB NEWS – Issue 12 – Summer 2016
RESEARCH HIGHLIGHTS
Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling
Chaperone-usher (CU) pili are hair-like appendages displayed on the surface of bacterial pathogens.
They are important virulence factors that facilitate host-pathogen interactions crucial for the
establishment and persistence of an infection, as well as biofilm formation. Type 1 and P pili are the
most abundant CU pili produced by uropathogenic Escherichia coli (UPEC), which are responsible for
~80% of all urinary tract infections (UTIs). The role of CU pili as critical virulence factors in UTIs is
firmly established. UTIs are a serious public health problem, with approximately 150-250 million
reported cases globally per year. Due to their prevalence, UTIs contribute significantly to antibiotic use
and the subsequent emergence of antibiotic resistance.
Work over the past three decades has revealed a lot about the overall architecture and assembly of CU
pili. Distinct pilus subunits are first secreted into the bacterial periplasm where they are stabilised by a
dedicated chaperone. These chaperone-subunit complexes are then shuttled to an outer membraneembedded nanomachine known as the usher, through which subunits are translocated and assembled
into pili. CU pili are organized into two subassemblies: the short and thin tip fibrillum and a 1-2 μm long
rod. UPEC can target specific host cell receptors in the bladder and the kidney by virtue of the adhesin
subunit located at the pilus tip. The pilus rod, by far the largest section of the pilus, is composed of
~1000 copies of a single subunit. The rod adopts a superhelical quaternary structure, which endows it
with remarkable spring-like properties, allowing pili to reversibly uncoil when subjected to flow-induced
shear forces in the urinary tract.
It is the structure of the type P pilus rod, which is the subject of a recent publication that resulted from
a collaboration between the laboratories of Professor Gabriel Waksman, Professor Ed Egelman,
Professor Scott Hultgren and Dr Frank di Maio. In this paper, a 3.8 Å resolution cryoelectron microscopy
structure was determined that revealed an unprecedented level of detail of these crucial bacterial
virulence factors. The structural work was complemented by biochemical and mutational analyses of
type P pili.
During infection of the urinary tract, UPEC are subjected to shear forces exerted by the flow of urine.
The unique spring-like properties of the pilus allow the force of urine flow to be dissipated over the
entire length of the pilus, taking the pressure off the adhesin-host cell receptor interaction. The newly
determined structure of the type P pilus explains these spring-like properties at the molecular level.
Individual subunits of the polymer are connected through the previously described mechanism of donorstrand exchange, where an N-terminal extension of one subunit complements the incomplete Ig-like fold
of an adjacent subunit. These interactions are hydrophobic and extremely stable. However, this study
by Hospenthal et al revealed the inter-subunit interaction network that enable these pili to wind and
stack into their superhelical quaternary arrangement. Importantly, these additional interactions are
largely polar in nature, so that when pili are subjected to stretching forces, these interactions begin to
progressively break. During this process, the polymer loses its quaternary structure but retains its
integrity by virtue of the strong, hydrophobic donor-strand exchange interaction. Therefore, this finely
tuned interplay of pilus rod interactions allows UPEC to cope in the challenging environment of the
urinary tract by maintaining their attachment to the host tissue.
In the future, this work may pave the way for the design of novel compounds and biologics that could
interfere with pilus rod formation or their structural integrity.
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ISMB NEWS – Issue 12 – Summer 2016
P Pilus structure determined by cryo-EM
E. coli harbouring
Chaperone-Usher (CU) Pili
top view
side view
residue-specific
structural information
spring-like
properties of CU pili
explanation of
mechanical properties
E. coli responsible for urinary
tract infections can retain a foothold in the
urinary tract when subjected to urine flows
Inter-subunit interactions
Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman
EH, Waksman G. Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling
Cell. 2016 Jan 14; 164(1-2):269-78. doi: 10.1016/j.cell.2015.11.049. Epub 2015 Dec 24
Dr Manuela Hospenthal and Prof Gabriel Waksman
ISMB Featured Articles and Commentaries
A commentary on the following article is available at http://www.ismb.lon.ac.uk/news.html
Cabrita LD, Cassaignau AME, Launay HMM, Waudby CA, Wlodarski T, Camilloni C, Karyadi M, Robertson
AL, Wang X, Wentink AS, Goodsell LS, Woolhead CA, Vendruscolo M, Dobson CM, Christodoulou J.
A structural ensemble of a ribosome–nascent chain complex during co-translational protein folding
Nature Structural & Molecular Biology 23, 278–285 (2016) doi:10.1038/nsmb.3182
Page 4
ISMB NEWS – Issue 12 – Summer 2016
STUDENT NEWS
Prizes awarded
The 2016 ISMB Graduate Symposium took place on 2nd and 3rd June. Congratulations to PhD
students Jenny Booker and Matt Colledge of Prof Bonnie Wallace’s group, who won the prizes
for best 1st year talk and best 3rd year talk respectively, and to Adrian Hodel, PhD student in the
London Centre for Nanotechnology, who won the prize for best poster.
Congratulations to Anaïs Cassaignau in Prof John Christodoulou's group, who has been awarded
a Bogue Research Fellowship to spend 5-6 months in 2017 with Professor Joseph Puglisi,
Stanford University, to develop single-molecule fluorescence methods to study co-translational
folding processes on the ribosome in real-time.
Chris Earl, a finalist Wellcome Trust PhD student in Dr Renos Savva’s
group, won the prize for Best Poster at the British Crystallographic
Association (BCA) Winter meeting on 16th December 2015. The
poster, entitled Structural studies of a viral uracil-DNA glycosylase
essential for DNA maintenance and replication, showed how the
group solved the crystal structure of the Kaposi's sarcoma-associated
uracil-DNA glycosylase (kUNG) in complex with DNA in order to
investigate the conformation of DNA presented by kUNG and the
potential link of this conformation with a non-canonical role of kUNG in viral DNA replication.
The award was presented by John Helliwell (emeritus professor at the University of
Manchester).
Dr Doris H.X. Quay was a Commonwealth International PhD Scholar in the Department of
Biological Sciences, Birkbeck, supervised by Prof Nicholas H. Keep and Dr Sanjib Bhakta and
successfully completed her PhD in 2015. Doris received a prestigious FEMS International Travel
Award to attend and present a research poster on structure and function of two key proteins in
bacterial dormancy at the Gordon Research Conference on New Antibacterial Discovery and
Development 2016 in Italy (13th - 18th March 2016).
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ISMB NEWS – Issue 12 – Summer 2016
UPDATE ON CENTRES & LABORATORIES
NMR at the ISMB: Focus on the Hansen group
The ISMB facility aims to expand the frontiers of biomolecular NMR spectroscopy through a combination
of advanced method development and their application to important questions in modern biology.
Particular expertise exists in understanding protein dynamics e.g. Hansen et al1,2 – NMR can report with
exquisite sensitivity and at residue specific level on biological motions across a range of timescales from
picoseconds to days. This can be used to facilitate functional explorations of the cell’s macromolecular
machines. We apply NMR spectroscopy to characterise the mechanisms of dynamic regulation in
enzymes including in histone deacetylases2,3 and kinases, and interactions of the large protein
complexes, such as the von Willebrand Factor4.
The last decade has seen major improvements and developments in NMR pulse sequences, the
necessary isotopic labelling schemes as well as in preparative biochemistry; NMR has thus been
revitalised and many new avenues for applications have opened as a result. Our contributions in this
regard include new methods for (i) studies of supramolecular systems with molecular masses in the
hundreds of kDa5, (ii) investigations of the structure and dynamics of low-populated protein states1,6,
and (iii) characterisations of the structural sampling of side chains of medium-large proteins2,5. Current
and future objectives are to develop strategies to apply NMR to an understanding of precisely how
motions and dynamics of macromolecular machines relate to biological function and regulation.
(A) An example of a novel pulse
sequence developed by the Hansen
group to probe the dynamics of arginine
side chains in large macromolecules2 (B)
The new 18.8 T (800 MHz) NMR
spectrometer installed in May 2016. (C)
Characterization of a low-populated (1%)
state of Histone deacetylase 8 using
recently developed relaxation dispersion
NMR methods by Hansen et al.1. Serine
phosphorylation, among others, regulates
the enzymatic activity by shifting the
population between interchanging
conformers. (D) Heterogeneity of the
active site of the UmpK kinase along the
enzymatic phosphoryl transfer reaction
probed by the sequence (A)
Key to success is the availability of state-of-the-art equipment and recent support from the Wellcome
Trust (through a multi-users equipment grant application led by Prof John Christodoulou (director of
the NMR facility)) that has allowed an essential upgrade to the facility: It now holds three NMR
spectrometers ranging in magnetic field from 11.7 Tesla to 18.8 Tesla with high-sensitivity cryogenic
radio-frequency probes installed for each. An experienced NMR spectroscopist (Dr Angelo Figuerido)
has overseen the recent upgrade and manages the facility. The new facility also opens the door for
high throughput NMR metabolomics explorations as well as for developments. The new facility will hold
a symposium to celebrate its upgrade in early 2017.
(1) Sauerwein AC, Hansen DF, (2015) Biol. Mag. Res. 32, 75-132, (2) Werbeck ND, Kirkpatrick J,
Hansen DF, (2013) Angw. Chemie, Intl Ed. 52, 3145-3147, (3) Kunze MB, Wright DW, Werbeck
ND, Kirkpatrick J, Coveney PV, Hansen DF, (2013) J. Am. Chem. Soc. 135 17862-17868, (4)
Shiltagh N, Kirkpatrick J, Cabrita LD, McKinnon TAJ, Thalassinos K, Tuddenham EGD, Hansen
DF, (2014) Blood 123, 4143-4151 (5) Hansen DF and Kay LE, (2011) J. Am. Chem. Soc. 133,
8272-8281 (6) Bouvignies G, Vallurupalli P, Hansen DF, … Kay LE, (2011), Nature, 477, 111114.
Dr Flemming Hansen
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ISMB NEWS – Issue 12 – Summer 2016
ISMB Biophysics Centre
New Instrumentation
Two important methods have been added to the portfolio of the Biophysics Centre at Birkbeck. The
BLItz instrument (http://www.fortebio.com/blitz.html) uses biolayer interferometry to measure
macromolecular interactions. Measurement takes place by dipping tips into small drops of just 4 ul, i.e.
very small samples. A wide range of tip surfaces exists to enable a variety of applications. Thanks a lot
to Dr Vitor Pinheiro who is making his instrument accessible to everyone through the Centre.
Furthermore, we have invested into a state-of-the art, user friendly dynamic light scattering
instrument, the pUNk (https://www.unchainedlabs.com/punk/). Measurement of macromolecular size
and polydispersity enables quick quality control of any macromolecular samples that should be routine
before downstream applications. DLS detects aggregation which is often invisible to the eye, gives
insight into oligomeric states, and also detects detergent micelles offering great applications for the
membrane protein field. There will be a launch event on June 23rd (soon to be advertised).
A Funded European Network
The ISMB Biophysics Centre is a founding member of the Association
of Resources of Biophysics Research in Europe (ARBRE). This network
has obtained EU funding (Cooperation in Science and TechnologyCOST) for the action “Between Atom and Cell: study of biological
macromolecules and assemblies as a whole, at an intermediate level
between atomic-resolution structural descriptions and cellular-scale
observations”. As part of this, funding of short-term scientific missions
is a central tool to foster interdisciplinary and international (European) cooperation. We are active in
this network and manage/participate in several of its working groups aiming to improve training,
standards and technology in biophysical measurements and stimulate research collaborations.
Dr Tina Daviter and Dr Mark Williams
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ISMB NEWS – Issue 12 – Summer 2016
AWARDS, PRIZES & GRANTS
Congratulations to Prof Carolyn Moores, who has joined the BBSRC’s Pool of Experts for 2016. Members
of the pool help to assess research grant proposals and identify the highest quality research for
investment.
Congratulations also to Prof Helen Saibil, who was recently elected as a Biochemistry & Molecular
Biology fellow of Academia Europaea.
Congratulations to Dr Matthew Gold, who has won an early career prize from the British Crystallographic
Association (BCA), awarded by the Biological Structures Group and sponsored by Rigaku. Matt collected
the prize at the BCA Spring Meeting held in Nottingham in April, where he presented his structural work
on a signalling protein complex that regulates synaptic strength.
Congratulations to Dr Vijay Chudasama, who was awarded the Outstanding Researcher Development
prize at the UCLU Student Choice Teaching Awards in April 2016 (voted for by UCL students).
Finally, congratulations to Prof Peter Rich on delivering the prestigious 2016 Sir Hans Krebs Memorial
Lecture in Sheffield University in February this year. Prof Rich has also been awarded the Peter Mitchell
Medal by the European Bioenergetics Conference organisation, which he will receive when presenting
the opening plenary lecture of the 19th EBEC meeting in Italy in July (http://www.ebec2016.org).
Recently awarded grants
Funding Body
Motor Neurone
Disease
Association
Awardee/s
Prof John
Christodoulou and
Dr Lisa Cabrita
Details
Awarded a MNDA PhD studentship of £91,000 for the project
Studies of the dynamic structure, misfolding and inhibition of
aggregation of the motor neurone disease associated protein
TDP-43. The project will apply NMR spectroscopy and
biophysical approaches to structural characterise TDP-43, to
both understand and intercept the molecular mechanisms
which permit it to transition to the aggregated state in motor
neurone disease.
EPSRC
Dr Vijay
Chudasama
Awarded a CASE studentship with MRC Technology of £95,000
for the project Creating Diagnostic Tools by Using Protein
Conjugates, running from 2016-2020.
BRC-HEFCE
Dr Vijay
Chudasama
Awarded a grant of £70,000 for the project Targeting cancer
with antibody-drug conjugates.
EPSRC (i-sense)
Dr Vijay
Chudasama
Awarded a grant of £160,000 for the project Controlled Protein
Orientation on Nanoparticles.
BBSRC
Dr Matthew Gold
Awarded a research grant of £353,505 for Local calcium
signalling in the postsynaptic density. The grant will support a
post-doc starting in Autumn 2016, who will apply structural
techniques including crystallography and crosslinking coupled
to mass spectrometry to investigate the positioning of calciumsensitive enzymes in the synapse.
BBSRC
Prof Helen Hailes
and Prof John
Ward
Awarded £457,840 for the project Enzyme Cascades and
Synthetic Biology Routes to Non-Natural Alkaloids.
BBSRC
Dr Bart
Hoogenboom, Dr
Alan Lowe and
Prof Helen Saibil
Dr Bart Hoogenboom (PI), Dr Alan Lowe and Prof Helen Saibil
awarded a responsive mode grant of £458,449 for the project,
Integrated microscopy approach to protein assembly on and in
membranes in April 2016.
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ISMB NEWS – Issue 12 – Summer 2016
MRC
Prof David Lomas
A grant of £2,047,855 has been awarded to Prof David Lomas,
Prof David Sattelle and Dr Bibek Gooptu for Alpha-1-antitrypsin
(AT) deficiency and the serpinopathies: pathobiology and new
therapeutic strategies (MR/N024842/1), to be carried out
between 2016 and 2021.
Royal Society
Dr Amandine
Maréchal
Awarded a grant worth £15,000 to purchase a high energy
pulsed laser for fast kinetics studies for the project, Towards
the resolution of the full catalytic cycle of cytochrome c
oxidase by time-resolved flow-flash FTIR spectroscopy.
BBSRC
Prof Carolyn
Moores
Awarded a grant of £390,887 for the project Molecular and
cellular dissection of kinesin motors Apicomplexa to reveal
roles in parasite proliferation, through which a post-doc will be
funded for 3 years.
BBSRC
Prof Christine
Orengo
Awarded a grant of £483,152 for the project Expanding
Genome3D and disseminating the structural annotations via
InterPro and PDBe.
BBSRC
Prof Andrea
TownsendNicholson
Awarded a research grant of £151,822 in May 2016 for the
project Development of an Experimental-Computational
Integrated Technology to Address the Residence Time of GPCR
Ligands.
BBSRC-FAPESP
Prof Bonnie
Wallace
Awarded a partnering grant of £35,000 for the project
Biophysical Studies of the Structure/Function of Antimicrobial
Peptides and Enzymes Isolated from Extremophile Organisms.
Grants applications – upcoming deadlines
Funding body
MRC Research Boards
Funding opportunities
Molecular and Cellular Medicine
Deadlines
Next call opens 25/07/2016 and
closes 07/09/2016.
BBSRC
Responsive Research Grants
Applications welcome at any time.
Next deadline: 4pm, 21st September
2016.
Wellcome Trust
Investigator Awards
Applications welcome at any time.
Summer 2016 round deadline: 27th
July 2016.
EPSRC
Fellowships
Applications welcome at any time.
Wellcome Trust
Small Grants
Applications welcome at any time.
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ISMB NEWS – Issue 12 – Summer 2016
UPCOMING EVENTS
2016 ISMB Symposium
The ISMB’s 7th Biennial Symposium will take place on Wednesday 29th and
Thursday 30th June 2016 in the Clore Management Centre, Birkbeck College.
The confirmed programme of speakers is available at
http://www.ismb.lon.ac.uk/symposium.html.
Registration is now closed, but anyone wishing to attend who is yet to register
should please contact the ISMB administrator ([email protected]).
4th Ion Mobility Mass
Spectrometry Special
Interest Group
Meeting
The range of applications using ion mobility mass spectrometry has enjoyed a
dramatic increase over the past ten years, driven both by the advent of
commercial instrumentation and the need for novel technologies for structural
characterisation. A number of UK groups are focused on the development and
application of ion mobility approaches, and many other research areas are
starting to benefit from this form of analysis.
The 4th Ion Mobility Mass Spectrometry special interest group meeting will be
held on Thursday 14th July 2016 within the ISMB at Birkbeck College London
(http://www.ismb.lon.ac.uk/http://www.bbk.ac.uk/biology/). It will showcase
recent advances in, and applications of, IM-MS research.
The plenary lecture will be delivered by Prof Edwin De Pauw from the University
of Liège (http://www.mslab.ulg.ac.be/).
Registration closes on Friday 30th June. To register, please visit:
https://www.eventbrite.co.uk/e/4th-ion-mobility-mass-spectrometry-sig-tickets25676847141
Shining Light on
Membrane Proteins
Symposium
Shining Light on Membrane Proteins, a symposium with 16 UK and international
speakers, will take place on Wednesday 10th August 2016 from 09:30 18:00 in Birkbeck Lecture Room B33.
For further details including the programme, please visit:
http://webspace.qmul.ac.uk/rwjanes/Symposium.htm
The event is expected to be oversubscribed and seating is limited, so parties
wishing to attend should please send an email to ‘[email protected]’
before 22nd July 2016 in order to reserve a place prior to the event being
opened to the public.
ISMB Seminar series,
Autumn 2016/17
The Autumn 2016 ISMB seminar series, Molecular Pathogenesis (Viruses,
Bacteria, Parasites) will run on Wednesdays in Glaxo-Wellcome seminar room
B62, Birkbeck from Wednesday 5th October 2016. Seminar details will be
announced at http://www.ismb.lon.ac.uk/seminar.html.
ISMB Friday Wraps,
Autumn 2016/17
Autumn 2016 ISMB Friday Wraps take place weekly in Glaxo-Wellcome seminar
room B62, Birkbeck and will recommence on Friday 7th October 2016.
Details will be announced at http://www.ismb.lon.ac.uk/fridaywrap.html.
News items are added monthly to the ISMB news page: www.ismb.lon.ac.uk/news
Please email items of news to the ISMB Administrator (Andrew Service): [email protected].
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ISMB NEWS – Issue 12 – Summer 2016