Overview of Gastric Cancer in the World

Overview of Gastric Cancer in the World

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@<-1($,;"Jiafu Ji MD.,
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Beijing"
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f2OO2'&"HR"Q32'&OO&()/)"Q"
Incidence:
Males: 6.8/100.000
Females: 3.9/100.000
Mortality:
Males: 5.0/100.000
Females: 2.7/100.000
Presence of national guidelines on gastric cancer: NO
Application of guidelines in clinical practice:
•  T2-4 cancer: perioperative EOX and D2 gastrectomy
•  T1 cancer operation only
National Associations for research on gastric cancer: NO
National Trials ongoing: NO
Relevant studies published in recent 2 years: NONE
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Gastrointestinal Surgeons (AUGIS) and the Royal College of Surgeons of England Clinical Effectiveness Unit
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Incidence:
Jewish: Males: 12,7/100.000
Arabs:
Mortality:
Jewish: Males: 7,4/100.000
Arabs:
Females: 5,8/100.000
Females: 3,2/100.000
Presence of national guidelines on gastric cancer: YES
Application of guidelines in clinical practice: NO
National Associations for research on gastric cancer: YES
ANZGOSA (Australian and New Zealand Gastric and Oesophageal Surgery Association)
AGITG ( Australasian Gastrointestinal Trials Group)
National Trials ongoing: YES
-  TOPGEAR: Trial of preoperative therapy for gastric and esophagogastric junction
adenocarcinoma. A randomised phase II/II trial of preoperative chemoradiotherapy versus
preoperative chemotherapy for resectable gastric cancer.
Relevant studies published in recent 2 years: 2011-2013: 18 studies published
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HK YANG, HH Kim,
HJ LEE, SH KONG, YS SUH
Incidence: Crude incidence rate in 2010
Males: 80.8/100.000
Females: 39.8/100.000
Of all cancers in 2010, 19.6% (male) and 10.0% (female)
Mortality: Crude mortality rate in 2011
Males: 25.2/100.000
Females: 13.6/100.000
Of all cancers in 2011, 14.1% (male) and 12.7% (female)
Presence of national guidelines on gastric cancer: YES
Korean Clinical Practice Guideline for gastric cancer
Application of guidelines in clinical practice: YES
National Associations for research on gastric cancer: YES
The Korean Gastric Cancer Association;
Korean Academy of Medical Sciences
National Trials ongoing: YES
• RCT comparing adjuvant capecitabine and oxaliplatin vs. observation for gastric cancer after D2 gastrectomy (CLASSIC)
• RCT comparing laparoscopic versus open gastrectomy for early gastric cancer (KLASS-01)
• RCT comparing laparoscopic gastrectomy with D2 dissection vs. open surgery for locally advanced gastric cancer
(KLASS-02)
• Multi-national phase II trial of laparoscopic total gastrectomy for stage I gastric cancer (KLASS-03)
• RCT comparing reductive gastrectomy plus chemotherapy vs. chemotherapy alone for stage IV gastric cancer (REGATTA)
• RCT comparing trastuzumab with chemotherapy vs. chemotherapy alone for HER2-positive advanced gastric cancer
(ToGA)
• Feasibility study of laparoscopy-assisted D2 distal gastrectomy to treat advanced gastric cancer (COACT1001)
• Multi-institutional study on the assessment of robotic surgery for gastric cancer
• Multi-national phase II trial of neoadjuvant imatinib for large gastric GIST
Relevant studies published in recent 2 years:
1. Bang YJ, et al. CLASSIC trial investigators. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy
(CLASSIC): a phase 3 open-label, randomised controlled trial. Lancet 2012 Jan 28;379(9813):315-21.
2. Han DS, et al. Nomogram predicting long-term survival after D2 gastrectomy for gastric cancer. J Clin Oncol 2012 Nov;
30(31):3834-40.
3. Kim HH, et al.. Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim
report--a phase III multicenter, prospective, randomized Trial (KLASS Trial). Ann Surg 2010 Mar;251(3):417-20.
4. Ahn HS, et al.. Evaluation of the seventh American Joint Committee on Cancer/International Union Against Cancer
Classification of gastric adenocarcinoma in comparison with the sixth classification. Cancer 2010 Dec;116(24):5592-8.
5. Song J, et al Korean Laparoscopic Gastrointestinal Surgery Study (KLASS) Group. Recurrence following laparoscopyassisted gastrectomy for gastric cancer: a multicenter retrospective analysis of 1,417 patients. Ann Surg Oncol. 2010 Jul;
17(7):1777-86.'
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?2>P>B'''''''''''''''''''''''
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?25CN>DH@BP'''''''''''''''''
@<-1($,;""
T.!.':YU6lK[l\*'!.':YUKl::l\'
`@?O$>%?=H'UD%E?="#'7<>?CF'"@A'i:':=.'8"##$@'
Incidence:
Males: 10.4/100.000
Females: 5/100.000
Mortality:
Males: 6.5/100.000
Females: 3,2/100.000
Presence of national guidelines on gastric cancer: NO
Application of guidelines in clinical practice: NO
German S3 Guidelines in some institutions
National Associations for research on gastric cancer:
Swiss Association for Clinical Cancer Research (SAKK)
National Trials ongoing: YES (Esophageal and Esophagogastric Junction Tumors)
SAKK 75/08 Multimodal therapy with and without cetuximab in patients with locally
advanced esophageal and esophagogastric junction cancers: an open-label phase
III trial (accrural almost completed)
Relevant studies published in recent 2 years: 5 (esophagogastric junction included)
Ruhstaller T, Pless M, Dietrich D, Kranzbuehler H, von Moos R, Moosmann P, Montemurro M, Schneider
PM, Rauch D, Gautschi O, Mingrone W, Widmer L, Inauen R, Brauchli P, Hess V.
Cetuximab in combination with chemoradiotherapy before surgery in patients with resectable, locally
advanced esophageal carcinoma: a prospective, multicenter phase IB/II Trial (SAKK 75/06).
J Clin Oncol. 2011 Feb 20;29(6):626-31.
C[@5H@BP'''''''''''''''''''''
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F&+%,2()%/+E)&'"=(+/&+/+"()"B23%1/&+%"H+(&)"-23)%,(/+;"&"@/%&9&)&'J+(+!'R!Y'K@N$C='[?%.R!Y'K@N$C='[?%'-()W();(J'
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Stage distribution of new cases, 2012
(according to TNM)
Stages I-II
36.3%
Stages III
24.6%
Stages IV
32.7%
Not specified
5.6%
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Other Countries
present at 10th IGCC
And participants
Albania
Algeria
Bahrain
Belgium
Bulgaria
Cameroon
2
1
1
8
5
1
Cape Verde
Christmas island
Colombia
Costa Rica
Croatia
1
1
1
4
1
Dominican
Republic
Greece
Hungary
indonesia
iran
Iraq
irlanda
Jordan
1
5
1
5
2
3
7
5
Kenya
Malaysia
Mexico
Nigeria
Panama
Paraguay
Peru
Qatar
Romania
Saudi Arabia
Serbia
Sierra Leone
Slovakia
Slovenia
1
1
3
2
1
1
5
1
3
1
1
1
10
1
South Africa
1
United Arab Emirates
Uzbekistan
Bolivarian Republic
of Venezuela
2
2
1
!"#$"%#&'()';+,-$%.'.+0.#$'
%0'-1#'&($34'
Estimated Stomach Cancer Incidence
Worldwide in 2008'
Countries present at 10th IGCC, not represented in the poster session
* Eucan 2012:http://eco.iarc.fr/EUCAN
Albania*
Algeria
Arab Emirates
Bahrain
Belgium*
Bulgaria*
Camerun
Cape Verde
Colombia
Costa Rica
Croatia*
Dominican Repub.
Greece*
Indonesia
Iran
Iraq
Jordan
Kazakistan
Kenya
Korea, republic of
36,2
7,1
5,60
8,1
12,20
21,40
2,5
7,8
23,40
28,50
21,80
8,9
11,10
9,40
21,90
4,40
5,60
33,50
9,20
62,20
Malaysia
Mexico
Nigeria
Panama
Paraguay
Peru
Portugal*
Qatar
Romania*
Russian, Moscow
Saudi Arabia
Serbia*
Sierra Leone
Slovakia*
Slovenia*
South Africa
Spain*
United Kingdom*
Uzbekistan
Venezuela
10,70
9,40
3,20
14,3
13,90
22,60
26,70
5,30
23,70
26,90
4,5
17,10
5,40
21,0
23,30
4,50
16,40
10,00
16,90
13,3
!"#$"%#&'()';+,-$%.'.+0.#$'
%0'-1#'&($34'
Estimated Stomach Cancer Incidence
Worldwide in 2008'
Countries present at 10th IGCC, not represented in the poster session
Albania*
Algeria
Arab Emirates
Bahrain
Belgium*
Bulgaria*
Camerun
Cape Verde
Colombia
Costa Rica
Croatia*
Dominican Repub.
Greece*
Indonesia
Iran
Iraq
Jordan
Kazakistan
Kenya
Korea, republic of
22.2
4.4
4.2
5.3
5.7
10.4
1.6
5.1
12.5
15.6
7.4
7.4
5.4
5.6
9
3.2
4.1
12.4
6.2
24.6
* Eucan 2012:http://eco.iarc.fr/EUCAN
Malaysia
6.4
Mexico
6.7
Nigeria
1.4
Panama
9.0
Paraguay
6.8
Peru
20
Portugal*
12.8
Qatar
4.8
Romania*
8.5
Russian, Moscow
11.7
Saudi Arabia
1.9
Serbia*
8.1
Sierra Leone
4.9
Slovakia*
9.8
Slovenia*
9.6
South Africa
2.3
Spain*
7.5
United Kingdom*
4.8
Uzbekistan
9.4
Venezuela
7.6
!"#$"%#&'()';+,-$%.'.+0.#$'
%0'-1#'&($34'
Estimated Stomach Cancer Incidence
Worldwide in 2008'
Countries present at 10th IGCC, not represented in the poster session
Albania*
Algeria
Arab Emirates
Bahrain
Belgium*
Bulgaria*
Camerun
Cape Verde
Colombia
Costa Rica
Croatia*
Dominican Republic
Greece*
Indonesia
Iran
Iraq
Jordan
Kazakistan
Kenya
Korea, republic of
31.0
6.7
4.8
6.3
7.8
17.9
2.5
7.8
17.8
23.6
17.6
6.8
9.6
8.8
19.9
4.3
5.2
28.3
8.9
22.8
* Eucan 2012:http://eco.iarc.fr/EUCAN
Malaysia
9.5
Mexico
7.9
Nigeria
3.1
Panama
12
Paraguay
11.9
Peru
19.5
Portugal*
19.5
Qatar
5.1
Romania*
19.2
Russian, Moscow
24
Saudi Arabia
4.2
Serbia*
14
Sierra Leone
5.2
Slovakia*
14.6
Slovenia*
16.2
South Africa
4.2
Spain*
10.8
United Kingdom*
6.6
Uzbekistan
14.4
Venezuela
11.4
!"#$"%#&'()';+,-$%.'.+0.#$'
%0'-1#'&($34'
Estimated Stomach Cancer Incidence
Worldwide in 2008'
Countries present at 10th IGCC, not represented in the poster session
Albania*
Algeria
Arab Emirates
Bahrain
Belgium*
Bulgaria*
Camerun
Cape Verde
Colombia
Costa Rica
Croatia*
Dominican Republic
Greece*
Indonesia
Iran
Iraq
Jordan
Kazakistan
Kenya
Korea, republic of
18.8
4.1
3.5
2.5
3.5
8
1.5
5.1
9.6
10.6
7.4
5.6
4.7
5.2
8.2
3
3.8
11
5.9
8.6
* Eucan 2012:http://eco.iarc.fr/EUCAN
Malaysia
5.6
Mexico
5.8
Nigeria
1.3
Panama
8
Paraguay
5.9
Peru
17.1
Portugal*
8.9
Qatar
4.8
Romania*
6.9
Russian, Moscow
9.9
Saudi Arabia
1.7
Serbia*
6.3
Sierra Leone
4.7
Slovakia*
6.9
Slovenia*
6.5
South Africa
2.2
Spain*
4.8
United Kingdom*
3.1
Uzbekistan
8.2
Venezuela
6.6
!"#$"%#&'()';+,-$%.'.+0.#$'
%0'-1#'&($34'
.'()(-&'"+%3=(/+"&,23)="%1/"G2,'="
1268 studies found for GASTRIC CANCER
www.clinicaltrials.gov
Numbers of cilinical trials in the countries present at 10th IGCC
not represented in the poster session
Albania*
Algeria
Arab Emirates
Bahrain
Belgium*
Bulgaria*
Camerun
Cape Verde
Colombia
Costa Rica
Croatia*
Dominican Repub.
Greece*
Indonesia
Iran
Iraq
Jordan
Kazakistan
Kenya
Korea, republic of
45
9
7
2
4
8
2
2
0
0
0
201
Malaysia
Mexico
Nigeria
Panama
Paraguay
Peru
Portugal*
Qatar
Romania*
Russian, Moscow
Saudi Arabia
Serbia*
Sierra Leone
Slovakia*
Slovenia*
South Africa
Spain*
United Kingdom*
Uzbekistan
Venezuela
5
18
1
5
9
13
12
25
3
0
4
1
9
53
71
-