Annual Report - UConn Health

CONNECTICUT CHILDREN’S MEDICAL CENTER - DEPARTMENT OF PEDIATRICS & PEDIATRIC SURGICAL SPECIALTIES
Annual Academic Report 2014
Chair’s Summary . . . . . . . . . . . . . . . . . . . 1
Human Genetics . . . . . . . . . . . . . . . . . . 44
The Year’s Highlights . . . . . . . . . . . . . . . . . 6
Infectious Diseases & Immunology . . . . . . . . . 46
Academic Administration . . . . . . . . . . . . . .
9
Neonatology . . . . . . . . . . . . . . . . . . . . 48
Adolescent Medicine . . . . . . . . . . . . . . . . 11
Nephrology . . . . . . . . . . . . . . . . . . . . . 52
Anesthesiology . . . . . . . . . . . . . . . . . . . 12
Pediatric Neurology . . . . . . . . . . . . . . . . . 53
Cardiology . . . . . . . . . . . . . . . . . . . . . 13
Pediatric Neurosurgery . . . . . . . . . . . . . . . 55
Cardiothoracic Surgery . . . . . . . . . . . . . . . 15
Orthopaedic Surgery . . . . . . . . . . . . . . . . 56
Child & Adolescent Psychiatry . . . . . . . . . . . 16
Otolaryngology . . . . . . . . . . . . . . . . . . . 58
Children’s Center for Community Research (C3R) .
18
Pain & Palliative Medicine . . . . . . . . . . . . . 59
Community Pediatrics . . . . . . . . . . . . . . . . 20
Pathology . . . . . . . . . . . . . . . . . . . . . . 61
Pediatric Critical Care . . . . . . . . . . . . . . . . 22
Plastic Surgery . . . . . . . . . . . . . . . . . . . 63
Pediatric Dentistry . . . . . . . . . . . . . . . . . 24
Pulmonary Medicine . . . . . . . . . . . . . . . . 65
Developmental & Rehabilitation Medicine . . . . . 26
Radiology . . . . . . . . . . . . . . . . . . . . . . 67
Digestive Diseases, Hepatology, & Nutrition . . . . 28
Research . . . . . . . . . . . . . . . . . . . . . . 69
Emergency Medicine . . . . . . . . . . . . . . . . 30
Rheumatology . . . . . . . . . . . . . . . . . . . 71
Pediatric Endocrinology & Diabetes . . . . . . . . 33
Transplant Surgery . . . . . . . . . . . . . . . . . 72
General Pediatrics . . . . . . . . . . . . . . . . . . 35
Urology . . . . . . . . . . . . . . . . . . . . . . . 73
Pediatric General & Thoracic Surgery . . . . . . . 37
Graduate Medical Education Residency . . . . . . . 75
Pediatric & Adolescent Gynecology . . . . . . . . . 39
Graduate Medical Education Fellowship . . . . . . 77
Hematology-Oncology . . . . . . . . . . . . . . . 40
Grants & Contracts . . . . . . . . . . . . . . . . . 80
Hospital Medicine . . . . . . . . . . . . . . . . . 42
2014 was an extraordinary year of growth in clinical
services, and achievement in research and education for
the faculty and staff of the Department of Pediatrics.
1
Chair’s Summary
Dear Colleagues and Friends,
It is my pleasure once again to share with you the
highlights of a remarkable year for the faculty and
staff of the Department of Pediatrics at the University of Connecticut School of Medicine and at
Connecticut Children’s Medical Center. As you
page through this report, my second as Chair of
Pediatrics and Physician-in-Chief, you will see that
2014 was an extraordinary year of growth in clinical services, and achievement in research and education for the faculty and staff of the Department
of Pediatrics. On these pages, we are also pleased
to highlight the contributions of our exceptional
colleagues in Surgical Specialties, Anesthesiology
and Radiology.
In a year crowned with many honors and awards,
several stand out. Two divisions – Endocrinology
and Urology – were recognized by US News &
World Report for their excellence in clinical care
and quality, education, and research. Dr. Jeffrey
Hyams, head of our Division of Digestive Diseases, Hepatology, and Nutrition, was honored as the
2014 recipient of the Murray Davidson Award.
The Endocrinology Division’s Diabetes Education
Program was reaccredited by American Association of Diabetes Educators. Dr. Kathleen Marinelli, from the Division of Neonatology, received the
United States Breastfeeding Committee’s Distinguished Service Award and the Academy of Breastfeeding Medicine Board Service Award. She also
was named Chair of the Baby-Friendly US NICU
Initiative, and elected to the Board of the International Lactation Consultant Association as director of Professional Development.
Two major challenges were confronted by our staff
this year, and both brought out the very best in us.
The outbreak of Ebola led Connecticut Children’s,
and in particular Dr. Andrea Benin and my colleagues in the Division of Infectious Diseases, to
enhance the medical center’s existing disaster pre-
paredness planning, and to focus on safely detecting, isolating, and treating children with possible
Ebola infection while minimizing the risk of contamination to staff, patients, visitors, and members of the community. While no cases of Ebola
were discovered or diagnosed at Connecticut Children’s, the medical center is now better prepared
to deal with circumstances of this kind.
The second major challenge affected our colleagues in the Emergency Department, which received its highest number of patients to date, and
within that number, an increasing proportion of
behavioral and mental health patients. In response
to this challenge, the Emergency Department was
partially redesigned to incorporate 11 rooms in a
sequentially securable area that incorporates safety design features. The division augmented its security presence with the addition of an assigned
security officer and an ED safety officer. A new ED
social worker evaluates low risk patients with the
aim of decreasing the average length of stay of behavioral health patients.
Pediatric UME had a highly successful year. The
overall satisfaction with the Ambulatory Pediatric
clerkship was rated as “excellent” or “good” by
more than 92 percent of medical students and more
than 91 percent of students rated their Advanced
Pediatric Experience (sub-internship) as “excellent” or “good.” Twenty-three percent of the graduating UConn medical school class entered a Pediatric or Pediatric combined residency. All students
matched at highly competitive programs including
Children’s Hospital of Philadelphia, Cincinnati
Children’s Hospital Medical Center, Yale-New
Haven Hospital, and UConn School of Medicine/
Connecticut Children’s Medical Center.
Our Residency program, under the exemplary direction of Dr. Ed Zalneraitis, continues its progress toward effectiveness in the ACGME’s Next
Accreditation System. Our faculty and residents
2
Chair’s Summary
instituted the new milestones-based assessments,
but found areas that might benefit from a bit of
fine-tuning. Changes were made to improve efficacy and efficiency, and these revisions were subsequently presented nationally at the Annual Spring
Meeting of the Association of Pediatric Program
Directors.
Our Fellowship program, overseen by Dr. Paola
Palma Sisto, continues to graduate highly trained
specialty physicians who are sought after by some
of the finest practices in the country. Our fellows
have attracted funding for research projects, had
numerous presentations accepted at national scientific meetings, and have been recognized through
travel grants and awards.
Clinically, the Department of Pediatrics and Connecticut Children’s Medical Center continue to
lead or participate in a number of national and regional programs. Led by Jeffrey Hyams, MD, the
Division of Digestive Diseases, Hepatology and
Nutrition is home to the Center for Pediatric Inflammatory Bowel Disease, the largest program in
the region between Boston and New York, which
currently provides care to over 600 children with
Crohn’s disease and ulcerative colitis. The division
also continues to be the Clinical Coordinating
Center for a $10.4 million grant from the National
Institutes of Health to lead the PROTECT Study:
Predicting Response to Standardized Pediatric
Colitis Therapy. The division also commenced formal collaborative work with Jackson Laboratories
to isolate and study intestinal stem cells from children with inflammatory bowel disease.
Our colleagues in the burgeoning Division of Hospitalist Medicine, under the exceptional leadership
of Anand Sekaran, MD, further standardized best
practices via multiple new Clinical Pathways, including both medical and, most recently, surgical
diagnoses. For asthma patients, the division has
been able to demonstrate reduced length of stay
and costs, with no increase in readmissions.
Dr. Cynthia Silva, head of the Division of Nephrology, was invited to participate in the prestigious Mid West Pediatric Nephrology Consortium
(MWPNC), a multicenter research collaborative
aimed at improving knowledge and clinical care
for children with renal disorders. Two new multidisciplinary clinics have been added: a chronic renal failure clinic for children with urological malformation; and a clinic for kidney/bladder stones.
Connecticut Children’s is the first Nephrology
practice in the state to offer such an array of clinics.
The Division of Pulmonology welcomed Dr. Jay
Kenkare, a certified sleep specialist and member of
the American Academy of Sleep Medicine. He led
the accreditation of our new 5-bed Pediatric Sleep
Laboratory, and has initiated a pediatric sleep clinic at our new multi-specialty medical surgical facility in Farmington.
Victor Herson, MD, and the colleagues he supervises as head of the Neonatalogy Division, incorporated the Neonatal Transport Program into
Connecticut Children’s Critical Care Transport.
They also established the CT Human Milk Research Center under the leadership of Elizabeth
Brownell, PhD.
The Division of Developmental & Rehabilitation
Medicine focused extensive resources on developing the Autism Spectrum Assessment Program
(“ASAP”). Under the leadership of Drs. Shailendra
Upadhyay and Felice Heller, the CTACH (Connecticut Adult Congenital Heart program) has
experienced tremendous growth. Dr. Upadhyay
and the members of the division hosted a full day
symposium dedicated to the care of adult congenital heart disease patients. At the other end of the
age spectrum, our fetal cardiac program, under the
leadership of Drs. Alicia Wang and Brooke Davey, partnered with high risk obstetrical services in
3
Chair’s Summary
Connecticut to provide advanced imaging for our
patients waiting to be born.
Our busy Office of Continuing Medical Education
accredited a total of 429 hours of instruction to
1,942 individual participants for a total of 24,477
contact hours. Accredited CME offerings include
Grand Rounds, regularly scheduled educational
series, and Pediatric and Mental Health Lecture
series.
In all of our endeavors, we are grateful for the
support and assistance of the Academic Leadership at the UConn School of Medicine and UConn Storrs, our CEO, Marty Gavin, the Executive
Management Team, and the Board of Directors at
Connecticut Children’s. I also wish to thank the
staff of the Division of Academic Administration.
Susan Duckworth led the division for many years
with creativity, grace and unfailing good humor.
When she retired this year, we welcomed Annamarie Beaulieu, MPH, who previously worked in the
Children’s Center for Community Research. Annamarie is off to a great start, and we wish her well
in a busy, multi-faceted position. The Department
of Pediatrics, the children’s hospital, and I owe an
ongoing debt of gratitude to Esperanza Lesmes,
Rachel Cunningham, Laurie Papacs, and Theresa
George for everything they do to keep things running smoothly. Finally, my sincere thanks goes to
Gigi Burke, PhD, who leads the Department of
Research at Connecticut Children’s, and her team;
Lisa Benson, Director of Grants and Sponsored
Programs, and her team; and Justin Radolf, MD,
Professor of Medicine and Pediatrics, and Senior
Scientific Advisor at Connecticut Children’s, for
their combined energy, steadfast support and mentorship of our faculty, and stewardship of our research enterprise.
Congratulations to you all for an outstanding year.
I look forward to 2015,
Sincerely,
Juan C Salazar, MD, MPH, FAAP
Professor and Chair, Department of Pediatrics
Physician-in-Chief, Connecticut Children’s Medical Center
5
Chair’s Summary
Dear Colleagues and Friends,
It is with great pleasure that we present the sixth annual report from the Department of Pediatric Surgical
Subspecialties of Connecticut Children’s Medical Center and the second combined report with the Department of Pediatrics. This report continues to reflect the
solid alignment between surgery and pediatrics and
the continued multi-disciplinary growth of combined
surgical and pediatric programs at Connecticut Children’s Medical Center.
Over the last year, the surgical services have continued
to experience growth, performing procedures on over
10,000 children with over 1,000 cases performed at
our new ambulatory surgery center in Farmington,
Connecticut. We continue to aggressively pursue our
vision to bring the very best surgical care to the children of the region while simultaneously pursuing our
two other core missions: research and education.
Some specific highlights from the past year include:
• T he
first 1,000 ambulatory surgeries were performed at the Connecticut’s Children’s Ambulatory
Surgery Center in Farmington.
• C onnecticut Children’s Medical Center remains the
exclusive site for pediatric surgical subspecialty training for the University of Connecticut School of Medicine surgical residency programs. Annually, dozens
of residents from the University of Connecticut and
other institutions receive their required pediatric surgical experience at Connecticut Children’s. The Pediatric General Surgery, Pediatric Orthopaedics, and
Pediatric Urology programs continue to train the future leaders in surgical subspecialties and have graduated several successful fellows since the last report.
We look forward to continued growth of innovative
programs and remain focused on providing the highest
quality, state-of-the-art care for children of the region.
have seen expansion of our full-time faculty
through the successful recruitment of some of the “best
and brightest” in their respective fields as evidenced by
our Neurosurgery recruitment from one of the most
prestigious training programs in the nation.
Sincerely,
I nnovation through research is integral to the mission of the department. We continue to focus efforts on children with solid tumors, premature lung
disease, otitis media, injury prevention, and sportsrelated injuries. Several federal grants and inven-
Peter J. Deckers MD Endowed Chair of Pediatric Surgery
Chief Physician Executive
Surgeon-in-Chief
Executive Vice President
Director, Division of Pediatric Urology
Connecticut Children’s Medical Center
e
•W
•
tion patents were submitted this year focusing on
diagnosis and treatment of these diseases. We also
have established research collaborations with Harvard Apparatus working on a new way to engineer
esophageal tissue, and the Massachusetts Institute
of Technology to improve our ability to diagnose
otitis media.
Fernando Ferrer, MD, FAAP, FACS
6
The Year’s Highlights
HONORS & AWARDS
CONFRONTING CHALLENGES
Two divisions – Endocrinology and Urology – were named
among the best in the nation by the 2014 U.S. News Media Group’s Best Children’s Hospitals rankings.
The unprecedented outbreak of Ebola in West Africa,
combined with the realities of rapid, global travel, led
Connecticut Children’s to enhance its existing disaster
preparedness planning to focus on safely detecting, isolating, and treating children with possible Ebola infection.
Led by Dr. Andrea Benin, with significant contributions
from Dr. Nicholas Bennett and the other members of the
Division of Infectious Diseases, the Ebola Taskforce developed clinical pathways, trained over 100 hospital staff
members, and remodeled four hospital rooms in the event
of having to care for children exposed to or infected with
any serious communicable infection. In five short but intense weeks, Connecticut Children’s significantly upgraded its ability to deal with healthcare disasters, including
infectious diseases, but with skills and equipment that
could be transferred to many other scenarios.
Dr. Jeffrey Hyams, head of the Division of Digestive Diseases, Hepatology and Nutrition, was honored as the
2014 Murray Davidson Award recipient. This award is
given by the Section on Gastroenterology, Hepatology
and Nutrition of the American Academy of Pediatrics and
recognizes an outstanding clinician, educator and scientist who has made significant contributions to the field of
pediatric gastroenterology and nutrition.
The Endocrinology Division’s Diabetes Education Program
was reaccredited by the American Association of Diabetes
Educators, one of only three programs certified in Connecticut in 2014, and the only one dedicated to the care of
children and adolescents with diabetes.
7
The Year’s Highlights
In 2014, the Emergency Department of Connecticut Children’s Medical Center treated 56,998 patients, its highest annual volume ever. Although the rate of growth has
slowed since 2010, this represents a 30% increase over
the last 10 years. The greatest clinical challenge continues to be the increasing number of behavioral/mental
health patients. In response to the serious safety issues
raised by some of these patients, the Emergency Department underwent a partial redesign and renovation of
some physical space.
ADVANCES & ACHIEVEMENTS
The Division of Digestive Diseases, Hepatology & Nutrition
was a leader on both the national and international stages.
Its Center for Pediatric Inflammatory Bowel Disease, the
largest program in the region between Boston and New
York, provided care to over 600 children with Crohn’s disease and ulcerative colitis. The division is the Clinical Coordinating Center for a $10.4 million grant from the National
Institutes of Health to lead the PROTECT Study: Predicting Response to Standardized Pediatric Colitis Therapy.
The division also commenced formal collaborative work
with Jackson Laboratories to isolate and study intestinal
stem cells from children with inflammatory bowel disease.
The Hospitalist Division further standardized best practice
via multiple new clinical pathways, including both medical and, most recently, surgical diagnoses. For asthma
patients, the division was able to demonstrate reduced
length of stay and costs, with no increase in readmits, and
with improvements in preventive care.
The department of Radiology saw major replacements and
upgrading of imaging equipment. These upgrades support
the philosophy of the department as an “Image Gently” and
“Step Gently” facility to provide appropriate imaging while
reducing the effects of ionizing radiation as much as possible. Video goggles were provided by a donor through the
Foundation. They can be worn by a child in the MR unit who
can watch a movie while having a lengthy imaging procedure with less dependence on sedation.
The Pediatric Cardiothoracic Surgery service, a merged
practice including Connecticut Children’s Medical Center
and Yale-New Haven Children’s Hospital, now submits
data to the Society of Thoracic Surgeons (STS) Congenital
Cardiac Surgery Database, which is the largest clinical database for our specialty in the world. The STS Database includes more than 94% of the Congenital Cardiac Surgery
programs in North America and serves as an excellent
benchmark for our outcomes, which remain significantly
better than the national average.
NEW SERVICES
Dr. Jay Kenkare joined the Division of Pulmonology this
year, coming to Connecticut Children’s from Gaylord
Sleep Medicine. A certified sleep specialist and member
of the American Academy of Sleep Medicine, Dr. Kenkare led the accreditation of the medical center’s new
5-bed Pediatric Sleep Laboratory, with an accompanying
increase in sleep studies from 350 to over 800 per year.
Dr. Kenkare also initiated a pediatric sleep clinic for the
evaluation and treatment of children with respiratory and
non-respiratory sleep problems.
The Division of Neonatology incorporated the Neonatal
Transport Program into Connecticut Children’s Critical
Care Transport, and the new program completed its first
full year of operations, transporting over 300 newborns
throughout the region and state.
The Division of Pediatric General & Thoracic Surgery
performed the first two gastric sleeves for the treatment
of adolescent obesity. This procedure is used for those
adolescents with severe obesity, and will complement the
laparoscopic band procedure for obesity treatment.
The Division of General Surgery spearheaded Connecticut Children’s continued involvement in the American
College of Surgeons’ Pediatric National Surgical Quality
Improvement Program (NSQIP), which is the first multispecialty program designed to measure and improve the
quality of children’s surgical care.
The Division of Developmental & Rehabilitation Medicine
focused extensive resources on developing the Autism
Spectrum Assessment Program (“ASAP”).
The surgical services of the Division of Gynecology expanded to include daVinci robotically-assisted minimallyinvasive gynecologic procedures for selected patients at
Connecticut Children’s.
8
The Year’s Highlights
The Division of Neurosurgery’s collaboration with the
Jackson Laboratory Avatar program was successful at
animal modeling of several malignant and rare brain tumors, providing an extraordinary study of tumor genomics
and chemotherapy response.
The division of Nephrology added two new multidisci-
plinary clinics: a chronic renal failure clinic for children
with urological malformation as well as a clinic for kidney/bladder stones. It is the first Nephrology section in
the state to offer such an array of clinics.
Pediatric General & Thoracic Surgery instituted rapid access to its clinics with same-day appointments for urgent
conditions.
9
Academic Administration
After eight years of successful and exemplary leadership, Susan Duckworth retired in May from her role as Director of
Academic Administration, and Administrator, Department of
Pediatrics. During her tenure, Connecticut Children’s faculty
and staff benefited greatly from Susan’s wisdom, dedication
and patience. Annamarie Beaulieu, MPH, moved to the Office of Academic Administration from Connecticut Children’s
Center for Community Research in May to take on the role of
Director and Administrator.
As an academic teaching hospital, Connecticut Children’s
strives to encourage, support, and recognize the academic
activities of its faculty, and support the highest quality Medical Education and Pediatric Fellowship programs. With faculty
based at multiple institutions, administration of the Department of Pediatrics, staffed at the University of Connecticut
Health Center by Laurie Papacs, Administrative Officer, and
Theresa George, Administrative Fiscal Assistant, is comprised
of centrally managed academic functions and decentralized
business and research management functions.
The Office of Academic Administration, in cooperation with
the Chair’s Office, staffed at Connecticut Children’s Medical
Center, manages academic appointment, promotion, and development activities, merit tracking for both in-residence and
affiliated faculty, academic faculty contracts, produces the
combined Department of Pediatrics & Pediatric Surgical Specialties Annual Report and the Faculty Resource Guide.
The office is staffed by Esperanza Lesmes, Academic Operations Program Manager; with assistance from Deborah Hornblow, per diem editor, and Brian Lesmes, per diem intern, and
includes the following areas:
Continuing Medical Education (CME): The Office of Continuing Medical Education, supported by Deirdre Palmer, Diane
Mouradjian, and Kenneth Spiegelman, MD, accredited a total
of 429 hours of instruction to 1,942 individual participants
for a total of 24,477 contact hours. Accredited CME offerings include Grand Rounds, and Pediatric, and Mental Health
Lecture series.
10
Academic Administration
Fellowships: Fellowship coordinators Kathleen Mikulak (who
left the department in October), Jack Wakefield and Marianne
Gonzalez, supported nine pediatric subspecialty fellowships
and 20 fellows. In 2014, the pediatric fellowship programs
graduated eight fellows and successfully filled seven of 10
available fellowship positions. In preparation for the 2015
year, coordinators effectively supported recruitment of 148
applicant interviews over 53 days throughout the year.
Maintenance of Certification: Eminet Abebe Gurganus, Maintenance of Certification (MOC) Program Manager, collaborated with faculty and community partners to develop four
new MOC activities for a total of 12 (five internal and seven
community-focused) MOC activities that promote quality improvement efforts within the hospital and serve as a bridge to
the community to disseminate the hospital’s excellent quality
improvement work to community practitioners. A generous
gift from United Healthcare in 2013 enabled the office to
begin development of a comprehensive database in support
of its MOC activities.
Medical Photography: Connecticut Children’s medical photographer, Michael McCarter, supports patient care, research,
legal documentation, continuing medical education and public
relations efforts with high quality photographic images that
enhance our website, publications, research articles and medical records.
STAFF
Susan Duckworth
Director, Academic Administration (retired, May 2014)
Annamarie Beaulieu, MPH
Director, Academic Administration
Laurie Papacs
Administrative Officer, Department of Pediatrics
University of Connecticut School of Medicine
Theresa George
Administrative Fiscal Assistant, Department of Pediatrics
University of Connecticut School of Medicine
Esperanza Lesmes
Academic Operations Manager
Connecticut Children’s Medical Center
Diane Mouradjian
Continuing Medical Education Coordinator
Deirdre Palmer
Continuing Medical Education Coordinator
Kathy Mikulak
Fellowship Coordinator
Marianne Gonzalez
Fellowship Coordinator
Jack Wakefield
Fellowship Coordinator
Eminet Gurganus
Maintenance of Certification Manager
Michael McCarter
Medical Photographer
11
Adolescent Medicine
During 2014, the Division of Adolescent Medicine transitioned from having a long-term Division Director and offering services and clinical education delivered primarily at St.
Francis Hospital to having an Interim Division Director and
offering services and clinical education delivered primarily at the Primary Care Center of Connecticut Children’s
Medical Center and other community sites.
The missions of the Division of Adolescent Medicine are to
provide comprehensive healthcare to adolescents between
the ages of 13 and 24, to educate health and mental health
providers regarding the needs of adolescents, to promote adolescent health in the community, and to advance adolescent
health through clinical research.
The clinical services provided by the division include the following:
• Adolescent Medicine primary care and consultative health
•
services at the Primary Care Center of Connecticut Children’s Medical Center
Detention Health Services: General adolescent health services are provided at three facilities: Broad Street Detention Center, an 88-bed locked facility for both males and
females; Washington Street Secure Community Residential Program, an 18-bed locked facility for females; and
Grace House, an 8-bed unlocked facility for females
Clinical services rendered by our clinical partners while mentoring the pediatric residents on their Adolescent Medicine
electives include the following sites:
Hartford Job Corps Center: providing primary care health
services to adolescents and young adults, under the direction of Medical Director Paul Clarke, MD
Westminster School, Simsbury, CT: providing primary care
health services to adolescents, under the direction of Medical Director Davis Smith, MD
Student Health Services at University of Connecticut,
Sports Injury Clinic: under the direction of Director of Medical Services Jeffrey Anderson, MD, FACSM
Women’s Ambulatory Health Services, Family Planning and
Teen Clinic: under the direction of Amy Nelson, MD
•
•
•
•
The division offers an Adolescent Medicine Selective, a onemonth ambulatory experience for all second-year pediatric
residents. An advanced adolescent medicine elective is tailored to the needs of third-year pediatric residents by request.
STAFF
Nancy H. Miller, MD
Interim Division Director
Jeffrey Anderson, MD, FACSM
Sudeshna Basu, MD
Paul Clarke, MD
Amy Nelson, MD
Grael O’Brien, MD
Davis Smith, MD
Elaine Yordan, MD
12
Anesthesiology
Drs. Michael Archambault and Carole Lin received
subspecialty certification in Pediatric Anesthesiology
awarded by the American Board of Anesthesiology this
past year. This brings the total to 11 members in the
division with subspecialty certification.
STAFF
The year 2014 was another busy one for the division. We
performed over 1,000 surgical procedures at the newly
opened Connecticut Children’s Ambulatory Surgery Center in Farmington. We have provided anesthesia services
for all surgical subspecialties including cardiac and neurosurgery. We also provide services for radiologic procedures including MRI, MRA CT scans and interventional
procedures. For pediatric patients requiring services at
Hartford Hospital, we provide anesthesia for nuclear
medicine, cardiac MRA and radiation oncology. Dr. Rutkowski and his regional anesthesia team provide support
for our sports medicine program both at the main campus and in Farmington. Dr. Archambault is continuing his
collaboration with Dr. Kavanaugh in the Division of Otolaryngology to provide simulation-based training for residents in both divisions as well as Operating Room staff.
Dr. Biello is working with Dr. Hyams in Gastroenterology
on a research project to define optimal doses of propofol
in pediatric patients during upper endoscopy. The Divisions of Otolaryngology and Anesthesiology are now
participating in a monthly joint airway conference where
the most challenging cases are discussed. Dr. Garrison is
working on a project looking at acupuncture and its benefit in surgical patients. Dr. McIsaac continues his work
on medical devices for austere environments including a
surgical cooling vest, chemical protective garments, and
a field-deployable fluid generation device. He also serves
on the American Society of Anesthesiologists Committee
on Trauma and Emergency Preparedness and is the Task
force Chair. Dr. Rossetti has been working with Operation
Smile and has completed mission trips to Honduras and
Malawi this past year. Dr. Kuntz once again has donated
his time for trips to Central America. Dr. Mark Indelicato
received his MSc in Management and Health Care Administration.
Christina Biello, DO
Craig Bonanni, MD, FAAP
Division Director
Michael Archambault, MD
Jessica Bland, MD
Amy Bouchard, DO, FAAP
Marrian Clubb, MD
Edward Cortland, MD, FAAP
Deanne Daggett, MD
John Garrison, MD
Mark Indelicato, MD, FAAP
Gregory Kernisan, MD
Richard Kuntz, MD
Carole Lin, MD
Anil Mathew, MD, FAAP
Joseph McIssac, MD, MS
Gerald Piserchia, MD
Valerie Rossetti, MD, MPH
Gregory Rutkowski, MD
Tracy Kunkel, APRN
Stephania Kushnir, APRN
13
Cardiology
The Division of Pediatric Cardiology at Connecticut Children’s Medical Center continues to serve as a resource
for physicians and a source of medical and surgical care
for children and adults with all types of cardiac issues.
The Division of Pediatric Cardiology works collaboratively
with primary care physicians, practitioners, family practitioners and adult-oriented physicians to provide state-of-theart care for all pediatric and adult patients with congenital
heart defects and heart rhythm abnormalities. Pediatric
Cardiology at Connecticut Children’s continues to evolve.
While strengthening our commitment to sub-specialization
and research, we are simultaneously growing our community commitments in order to provide cardiology care to the
children of Connecticut and the surrounding region.
Connecticut Children’s has become a leader in the care of
adults with congenital heart disease. Under the leadership
of Drs. Shailendra Upadhyay and Felice Heller, the CTACH
(Connecticut Adult Congenital Heart program) has experienced tremendous growth. We have continued to reach
out and engage our adult care providers and adult hospitals to partner in the care of these patients in an effort to
maximize positive outcomes for these patients. Dr. Upadhyay and the members of the division hosted a full day
symposium dedicated to the care of adult congenital heart
disease patients. We plan to make this an annual event.
At the other end of the age spectrum, we also have grown
tremendously with our fetal cardiac program. Under the
leadership of Drs. Alicia Wang and Brooke Davey, we have
partnered with the Obstetrical community and the high risk
Obstetrical services in Connecticut to provide advanced
imaging for our patients waiting to be born. The care of
these high risk children is coordinated with Obstetrics,
Neonatology, Cardiology, and Cardiac Surgery services in
order to maximize the outcome for these fragile patients.
Dr. Davey continues her research on the stress responses
of pregnant women with a child diagnosed with a congenital heart defect.
Echocardiography and advanced imaging is one of the
foundations of pediatric cardiology. The division has continued its excellence in echocardiography and has expanded
into 3-dimensional imaging and other forms of advanced
imaging. This improved imaging will better demonstrate the
unique anatomy of each abnormality and improve the outcome of our patients undergoing open heart surgery and
trans-catheter procedures to correct their congenital heart
defects. We anticipate that the echocardiography services
at Connecticut Children’s will soon become nationally certified by the ICAEL, the certifying agency for echocardiography labs.
Our Cardiac MRI program has grown exponentially since
its inception, and continues to grow with the increased
need for anatomic and physiologic imaging. Due to size
and ultrasound imaging limitations, cardiac MRI has become increasingly utilized for our adult patients. We anticipate further growth in Cardiac MRI and other imaging
modalities and look forward to further recruitment to help
support these initiatives. In contrast to previous eras of
cardiology and cardiac surgery care, many patients do not
need invasive studies including radiation and only need
noninvasive imaging such as echo and MRI prior to their
surgery. Under the leadership of Dr. Olga Salazar, the MRI
program is a focus of research in pediatric cardiology and
collaborative research between pediatric cardiology and
pediatric hematology/oncology.
Even as we have been growing in our sub-specialization,
we have grown our outreach services and look to further
expand our presence throughout Connecticut, partnering
with community physicians and practitioners. We believe
that many cardiology patients can be cared for locally without ever having to make a trip to Connecticut Children’s
Medical Center. Therefore, at Connecticut Children’s facilities in Hartford, we have focused on the care of the complex pediatric and adult patients with congenital heart disease in order to maintain and improve the health of these
patients.
PUBLICATIONS
Davey B, Donofrio M, Moon-Grady A, Fifer C, Cuneo B,
Falkensammer C, Szwast A, Rychik J. Development and
validation of a fetal cardiovascular disease severity scale.
Pediatr Cardiol. 2014 Oct;35(7):1174-80. Epub 2014
May 7.
14
Cardiology
FACULTY
Derek Obayashi, MD
Harris Leopold, MD,
Division Chief
Olga Toro-Salazar, MD
Frederic Bernstein, DO
Brooke Davey, MD
Felice Heller, MD
Seth Lapuk, MD
Shailendra Upadhyay, MD
Alicia Wang, MD
Amy Carlucci Wu, MD
Leon Chameides, MD
Professor Emeritus
15
Cardiothoracic Surgery
The Pediatric Cardiothoracic Surgery service represents a merged practice including Connecticut Children’s Medical Center and Yale-New Haven Children’s
Hospital. This joint program provides world-class surgical care to the children and adults of Connecticut born
with congenital heart disease.
Both programs now submit data to the Society of Thoracic Surgeons (STS) Congenital Cardiac Surgery Database,
which is the largest clinical database for our specialty in
the world. The STS Database includes more than 94%
of the Congenital Cardiac Surgery programs in North
America and serves as an excellent benchmark for our
outcomes, which remain significantly better than the national average. Our results will now be included in the STS
Public Reporting initiative and will be available on both
the STS and the Consumer Reports websites when this
program is rolled out later this year.
The section of Pediatric Cardiothoracic Surgery remains
committed to providing cutting-edge care for the congenital heart disease patients in our region. Dr. Mohsen
Karimi continues to make strides with the blood conservation program, allowing us to perform transfusion-free
open-heart surgery for many of our patients while limiting
transfusions for everyone.
PUBLICATIONS
Poynter JA, Bondarenko I, Austin EH, DeCampli WM,
Jacobs JP, Ziemer G, Kirshbom PM, Tchervenkov CI,
Karamlou T, Blackstone EH, Walters HL 3rd, Gaynor JW,
Mery CM, Pearl JM, Brothers JA, Caldarone CA, Williams
WG, Jacobs ML, Mavroudis C; Congenital Heart Surgeons’ Society AAOCA Working Group. Repair of anomalous aortic origin of a coronary artery in 113 patients: a
Congenital Heart Surgeons’ Society report. World J Pediatr Congenit Heart Surg. 2014 Oct;5(4):507-14.
Kanter KR, Kirshbom PM, Kogon BE. Surgical repair of
pulmonary venous stenosis: a word of caution. Ann Thorac Surg. 2014 Nov;98(5):1687-91; discussion 1691-2.
Kirshbom PM. Percutaneous device occlusion and minimally invasive surgical repair for perimembranous ventricular septal defect. [invited commentary] Ann Thorac
Surg. 2014 Apr;97(4):1406.
STAFF
Paul Kirschbom, MD
Division Chief
Mohsen Karimi, MD
16
Child & Adolescent Psychiatry
The Division of Child and Adolescent Psychiatry remains
a highly vibrant resource within the Department of Pediatrics at the Connecticut Children’s Medical Center. Its tripartite mission is: providing the highest quality of mental
health care for children/adolescents and their families in the
Greater Hartford area, providing the highest quality of mental health education to trainees and community providers,
and expanding the research base within the field of Child
and Adolescent Psychiatry and Psychology.
At Connecticut Children’s, the division’s services include: a
consultation/liaison service that provides inpatient and outpatient evaluation and treatment services of children and adolescents with co-morbid psychiatric and medical conditions;
emergency psychiatric assessment, triage and disposition
services within the Connecticut Children’s Emergency Department; and psychological services including assessment
and psychotherapy, through the Divisions of GI, Endocrinology, Obesity and Weight Management, Hematology/Oncology, and Pain/Rehabilitation.
At the Institute of Living, (IOL), clinical services include: individual, group, and family therapies; pharmacotherapy; and
diagnostic evaluations. These services are provided through:
inpatient units for children and adolescents; the Child and
Adolescent Rapid Emergency Services (C.A.R.E.S) unit, a
very short-term setting interfacing directly with Connecticut
Children’s Emergency Department that focuses on the assessment, stabilization, and disposition of children and adolescents in acute behavioral crisis; the Grace Webb School, a
therapeutic educational setting for children and adolescents
with co-existing psychiatric and learning difficulties; an outpatient child and adolescent clinic; an Extended Day Treatment
Program (TOPS), for older school-aged children; a partial
hospital program for children and adolescents; and an Autism
Consultation Service.
We have become one of the hubs for the new ACCESS-Mental Health CT program, a collaborative educational, consultation and assessment program between primary care providers and child and adolescent psychiatrists. We have continued
a descriptive study of our Eating Disorder protocol while also
implementing a somatic symptom disorder clinical pathway.
Connecticut Children’s and the Institute of Living remain highly
active teaching sites for many trainees: Child and Adolescent
Psychiatry fellows; General Psychiatry residents; Psychology
fellows; Pediatric residents and medical students.
PUBLICATIONS
Guite JW, Kim S, Chen C-P, Sherker JL, Sherry DD, Rose
JB, Hwang W-T. Pain beliefs and readiness to change among
adolescents with chronic musculoskeletal pain and their
parents before an initial pain clinic evaluation. Clin J Pain.
2014;30(1):27-35. PMCID: PMCPMC 3742695.
Guite JW, Kim S, Chen C-P, Sherker JL, Sherry DD, Rose
JB, Hwang W-T. Treatment expectations among adolescents
with chronic musculoskeletal pain and their parents prior to
an initial pain clinic evaluation. Clin J Pain. 2014;30(1):17-26.
PMCID: PMCPMC 3742613.
Malik S, Caley CF, Azeem MW. Psychopharmacogenomics –
a new tool for the prescribing physician. J Pakistan Psychiatric
Society. 2014 Jul-Dec; 11(2):12-15.
Goyal R, Arroyave A, Malik S. Urticaria and angioedema
secondary to methylphenidate exposure in a young child. J
Child Adoles Psychopharmacol. 2014;24:1-3.
Haney-Caron E, Caprihan A, Stevens MC. DTI-measured
white matter abnormalities in adolescents with Conduct Disorder. J Psychiatr Res. 2014 Jan;48(1):111-20. PubMed
PMID: 24139595; PubMed Central PMCID: PMC3863548.
Dager AD, Jamadar S, Stevens MC, Rosen R, JiantonioKelly RE, Sisante JF, Raskin SA, Tennen H, Austad CS, Wood
RM, Fallahi CR, Pearlson GD. fMRI response during figural
memory task performance in college drinkers. Psychopharmacology (Berl). 2014 Jan;231(1):167-79. PubMed PMID:
23949205; PubMed Central PMCID: PMC3877735.
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive-compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Res. 2014
Feb 28;221(2):142-8. PubMed PMID: 24389161; PubMed
Central PMCID: PMC3946244.
Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging Behav. 2014 Mar;8(1):87-96. PubMed
PMID: 23949893; PubMed Central PMCID: PMC3925762.
Tyson K, Kelley E, Fein D, Orinstein A, Troyb E, Barton M, Eigsti
IM, Naigles L, Schultz RT, Stevens MC, Helt M, Rosenthal
M. Language and verbal memory in individuals with a his-
17
Child & Adolescent Psychiatry
tory of autism spectrum disorders who have achieved optimal outcomes. J Autism Dev Disord. 2014 Mar;44(3):64863. PubMed PMID: 23982487; PubMed Central PMCID:
PMC3948218.
STAFF
Rosenfeld ES, Pearlson GD, Sweeney JA, Tamminga CA, Keshavan MS, Nonterah C, Stevens MC. Prolonged hemodynamic response during incidental facial emotion processing
in inter-episode bipolar I disorder. Brain Imaging Behav. 2014
Mar;8(1):73-86. PubMed PMID: 23975275; PubMed Central PMCID: PMC3944373.
J. Craig Allen, MD
Kenneth Robson, MD
Michal Assaf, MD
Carlos Salguero, MD
Sudeshna Basu, MD
Rosemary
Coratola, PsyD, LMFT
Troyb E, Orinstein A, Tyson K, Helt M, Eigsti IM, Stevens MC,
Fein D. Academic abilities in children and adolescents with
a history of autism spectrum disorders who have achieved
optimal outcomes. Autism. 2014 Apr;18(3):233-43. PubMed
PMID: 24096312.
Eric D. Cohen, MD
Balodis IM, Grilo CM, Kober H, Worhunsky PD, White MA,
Stevens MC, Pearlson GD, Potenza MN. A pilot study linking
reduced fronto-Striatal recruitment during reward processing
to persistent bingeing following treatment for binge-eating
disorder. Int J Eat Disord. 2014 May;47(4):376-84. PubMed
PMID: 24729034; PubMed Central PMCID: PMC3986812.
Orinstein AJ, Stevens MC. Brain activity in predominantly-inattentive subtype attention-deficit/hyperactivity disorder during an auditory oddball attention task. Psychiatry Res. 2014
Aug 30;223(2):121-8. PubMed PMID: 24953999; PubMed
Central PMCID: PMC4120259.
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun
VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS,
Pearlson GD. Resting state electroencephalogram oscillatory
abnormalities in schizophrenia and psychotic bipolar patients
and their relatives from the bipolar and schizophrenia network
on intermediate phenotypes study. Biol Psychiatry. 2014 Sep
15;76(6):456-65. PubMed PMID: 24439302.
Robert Sahl, MD
Division Head
Kim Brownell, MD
Julie Goslee, MD
Mirela Loftus, MD
Daane Logsdon, DO
Salma Malik, MD
Lynn Mangini, MD
Lisa Namerow, MD
Jonathan Raub, MD
Francisco Ripepi, MD
Jessica Guite, PhD
Mary Gratton, PhD, LCSW
Robert Katz, JD
Barbara Rzepski, PhD
Melissa Santos, PhD
Michael Stevens, PhD
Kevin Tsang, PsyD
Suzanne Femino, APRN
18
Children’s Center for
Community Research (C3R)
In 2014, the Children’s Center for Community Research welcomed Administrative Assistant Magdalena
Owczarska and Research Associate Kaitlin Flannery to
the team.
The Children’s Center for Community Research (C3R)
is dedicated to improving the health and well-being of
children and their families by conducting communitybased collaborative research and programs. C3R works
to encourage, facilitate, and provide a mechanism for program dissemination and outcomes assessment of clinical, behavioral and translational research. This research
is conducted by investigators with and in community settings including schools, homes, community organizations,
hospitals and ambulatory practice settings. Within C3R,
research is conducted in three broad areas: Adolescent
health, childhood asthma, and childhood obesity.
ADOLESCENT HEALTH
During the spring of 2014, C3R administered follow-up
surveys to 258 Adolescent Adjustment Project (AAP)
participants. All of the participants previously were surveyed throughout their high school years and are now in
their early 20’s. In the fall of 2014, C3R also administered
surveys to a nationwide sample of 600 18-22 year-old
youth. Data from these surveys will be used to examine
risk and protective factors involved in the development of
psychological problems and substance use. During 2014,
Dr. Ohannessian collaborated as a Co-investigator with
Dr. Yifrah Kaminer from the Psychiatry Department at
UConn Health on two NIH-funded projects focusing on
treatments for adolescent substance use disorders. Dr.
Ohannessian also served as a guest editor of a special
issue of the Journal of Youth Development focusing on
media use in youth. Finally, an article published in Parenting: Science and Practice, authored by Drs. Ohannessian
and De Los Reyes, “Discrepancies in adolescents’ and
their mothers’ perceptions of the family and adolescent
anxiety symptomatology,” was included in an online collection featuring the most downloaded articles published
in Routledge Behavioral Sciences journals in 2014.
CHILDHOOD ASTHMA
This past year has been a busy time for C3R’s Asthma
Center, which entered its third year of collaboration with
Hartford Public Schools to pilot the Building Bridges
school-based asthma program. Between the 2013-14
and 2014-15 school year, the program expanded from
3 to 10 Hartford elementary schools and has been wellreceived by the community. Funded by the GlaxoSmithKline Foundation and in collaboration with Denver Public
Schools and Children’s Hospital of Colorado, the program
aims to improve academic performance by decreasing
school absences through improved asthma control in
inner-city students. During 2014, preliminary data demonstrated that enrollment in the program for one year resulted in an 11.8% decrease in school absences.
In 2014, the Easy Breathing© program celebrated 16
years. Easy Breathing© has served over 135,000 children in Connecticut, of whom more than 35,000 have
been diagnosed with asthma. In early 2014, Akron Children’s Hospital was trained in the program and began implementing it within the primary care community. Currently, Easy Breathing© is active in 5 states – Ohio, Kansas,
Kentucky, Florida, and Vermont. The Easy Breathing©
program also initiated a collaboration with a start-up incubator called CoHero. CoHero has developed a metered
dose inhaler with a sensor that links to a smartphone app.
We currently are working with CoHero to assess the need
or desire in the primary care community for this type of
technology and are asking pediatricians how they could
use this information to better serve their patients.
CHILDHOOD OBESITY
C3R’s Early Childhood Obesity (ECHO) Prevention Program, funded by NICHD, recruited 58 mother/infant dyads between 6 participating NFN sites in Hartford under
the assistance of James Wiley, the program coordinator.
The first mother/infant dyad completed the 12-month
intervention in December 2014. The Hartford Childhood Wellness Alliance underwent a 360 degree review
this past year and created a strategic plan for the next
3 years. More than 35 Alliance partners participated in
the strategic planning retreat and the 4 workgroups that
were created. The strategic plan was approved by the Alliance at a special meeting in December 2014. Jacqueline Ortiz-Miller, CHW, has been recruited to serve as the
new Coordinator of the Hartford Childhood Wellness Alliance. Steps to Growing Up Healthy for childcare centers
19
Children’s Center for
Community Research (C3R)
wrapped up in December 2014. A training manual for
child care center staff has been created and will be rolled
out to staff in the spring of 2015.
This past year, C3R continued to expand its collaborations with multiple external partners including the University of Connecticut at Storrs, UConn Health, the University of Delaware, the University of Maryland, Pennsylvania
State University, the University of New Orleans, Rutgers
University, the University of Colorado, Utrecht University
in the Netherlands, Nationwide Children’s Hospital, the
State of Connecticut Department of Public Health, the
City of Hartford Department of Health and Human Services, the Hartford Foundation for Public Giving, and the
Community Health Network of CT.
PUBLICATIONS
Gorin AA, Wiley J, Ohannessian C, Hernandez D, Grant
A, Cloutier MM. Steps to Growing Up Healthy: A pediatric primary care based obesity prevention program for
young children. BMC Public Health. 2014;14:72-82.
Hollenbach JP, Cloutier MM. Implementing school
asthma programs: lessons learned and recommendations. J Allergy Clin Immunol. 2014 Dec;134(6):1245-9.
Ohannessian CM, Boyd M, Kirsh S, editors. Media and
youth development: an overview of issues, theory and research. Special issue. J Youth Dev. 2014;9(1).
Rosas-Salazar C, Forno E, Brehm JM, Han Y-Y, AcostaPerez, E, Cloutier MM, et al. Breastfeeding duration and
asthma in Puerto Rican children. Pediatr Pulmonol. 2014
Aug 6.
Schifano ED, Hollenbach JP, Cloutier MM. Mismatch
between asthma symptoms and spirometry - implications for managing asthma in children. J Pediatr. 2014
Nov;165(5):997-1002.
Wiley JF, Cloutier MM, Wakefield DB, Hernandez DB,
Grant A, Beaulieu A, Gorin AA. Acculturation determines
BMI percentile and noncore food intake in Hispanic children. J Nutrition. 144(3):305-10, 2014.
STAFF
Christine Ohannessian, PhD
Director, C3R
Michelle Cloutier, MD
Director, Asthma Center
Jessica Hollenbach, PhD
Magdalena Owczarska
Autherene Grant
Kaitlin Flannery
Christine Langton
Ohannessian CM. Anxiety and substance use during
adolescence. Subst Abuse. 2014;35(4):418-25.
Carol Vinick
Ohannessian CM, Boyd M, Kirsh S. Media and youth
development: an overview of issues, theory, and research.
J Youth Dev. 2014;9(1):6-13.
Jacqueline Miller-Ortiz
Ohannessian CM. A longitudinal examination of the relationship between media use and self-competence during adolescence. J Youth Dev. 2014;9(1):143-156.
Ohannessian CM, De Los Reyes A. Discrepancies in
adolescents’ and their mothers’ perceptions of the family and adolescent anxiety symptomatology. Parent Sci
Pract. 2014;14(1):1-18.
James Wiley
20
Community Pediatrics
The Division of Community Pediatrics is the largest division
at Connecticut Children’s Medical Center. There are 21 active, 20 courtesy, and 90 refer-and-follow members.
The division is concerned with issues regarding the advocacy
and delivery of healthcare to children in community-based settings and institutions such as office-based practice, well-baby
nurseries, community health centers, schools, camps, fostercare adoptive services, etc. Our members provide primary pediatric care to most children from the Greater Hartford area.
Members see to well care, sick care, and behavioral health
needs of children. Member pediatricians diagnose most chronic diseases of children in our area. Our members work closely
with specialists in other divisions to coordinate care for the sickest children in the community.
Pediatricians in the division consult with local school systems
to address public health and sports medicine issues. Our members serve on a variety of hospital committees, and they provide
neonatal care at John Dempsey Hospital, Hartford Hospital,
Manchester Memorial Hospital, and Saint Francis Hospital.
Members are interviewed by public media including radio, television and newspapers on a wide variety of pediatric and public health care issues of local and national interest, including
childhood obesity, school safety and bullying, vaccine advocacy,
and changes to guidelines for cold and cough care for young
children.
tive, to help coordinate care for children with special health care
needs; and the creation of collaborative practice models/comanagement guidelines, including migraine headaches, Lyme
disease, voiding dysfunctions, premature adrenarche, and concussions.
Members are actively involved in ongoing education through
Grand Rounds and evening lecture series in pediatrics and
child mental health, to promote topics of interest to the community physicians as well as nurse practitioners, physician assistants and school nurses who care for children in the community setting.
The division sponsors a lectureship in honor of Christopher
O’Connor, MD, that addresses topics of concern to communitybased pediatrics.
PUBLICATIONS
Feyissa E, Cornell E, Chandhok L, Wang D, Ionita C, Schwab J,
Kostyun R, Wilion F, Rubin K. Impact of co-management at
the primary-subspecialty care interface on follow-up and referral patterns for patients with concussion. Clin Pediatr. 2015. doi:
10.1177/0009922814566929.
STAFF
Douglas MacGilpin, MD
co-Division Head
Division members provide instruction and supervision for student and resident continuity practices as well as the pediatric
ambulatory rotation for third year students. In addition to providing rich and varied clinical experiences, members educate students and residents about external issues that influence child
health care, such as delivery care models, working with consultants and other professionals to address health care plans
for children, coding and other business practicalities in community pediatrics, and time and personal health management. We
seek to identify innovative practice styles in health care delivery
and opportunities to improve patient education and health outcomes.
Larry Scherzer, MD
co-Division Head
Members engage in many collaborative programs within
broader department- and state-based initiatives to provide better care for children. These include the Easy Breathing© Program, which has led to improved health practices and better
outcomes for children with asthma; the Medical Home initia-
Thomas B. Binder, MD
Robert S. Adamenko, MD
Luis Alonso, MD
Brenda K. Balch, MD
Meredith W. Barrows, MD
Amy H. Baumer, MD
Lucia C. Benzoni, MD
Nancy B. Brown, MD
David L. Brown, MD
21
Community Pediatrics
William Brownstein, MD
Brad Jubelirer, MD
Chitraleka Ramanan, MD
Leon Chameides, MD
Professor Emeritus
Anjum Khera, MD
Cynthia C. Roque, MD
Natalie Komaiszko, MD
Viviann Rubin, MD
Gubbanna S. Kumar, MD
Kweku G. Sam, MD
Sydney Ladenheim, MD
Jennifer Schwab, MD
Jerome Lahman, MD
Gavin Schwarz, MD
Christine Lamoureux, MD
John F. Siraco, MD
John H. Lavalette, MD
Candra L. Smith-Slatas, MD
Carol Leicher, MD
Daniel L. Spada, MD
Deepa Limaye, MD
Kenneth N. Spiegelman, MD
Foong-Yi Lin, MD
Prasad Srinivasan MD
Stephen J. Maddox, Jr., MD
Martha Sternberg, MD
Asha Manaktala, MD
Carrie S. Streim, MD
Kathleen A. Marinelli, MD
Charles Thompson, MD
Linda Mathew, MD
Robert R. Toscano, MD
John Mathews, MD
Kerline A. Vassell, MD
Bruce McDonald, MD
Christopher Veale, MD
Louis M. Mendelson, MD
Rachna Walia, MD
Judith C. Meyers, PhD
Ramindra Walia, MD
Debora Mihaley-Sobelman, MD
Matthew Warren, MD
Donald Mordavsky, MD
Harry C. Weinerman, MD
Sylvia Nash, MD
Allison Whitaker, MD
Margaret O’Neill, MD
Felicia M. Wilion, MD
James O’Connor, MD
Richard S.K. Young, MD
Kathy Pae, MD
Robert W. Zavoski, MD
Hemant K. Panchal, MD
Sophia Zervas-Grant, MD
Elizabeth T. Pericat, MD
Barbara Ziogas, MD
Carolyn Clark, MD
Paul Clarke, MD
Della M. Corcoran, MD
Allison S. Cowl, MD
J. Michael Curi, MD
Sachin Dhingra, MD
Louis DiMauro, MD
Leo J. DiStefano, MD
Allyson Duffy, MD
Nancy S. Dunbar, MD, MPH
Jeffrey M. Factor, MD
Parvin Fadakar, MD
John J. Fote, MD
Cecille Freilich, MD
Thomas Fromson, MD
Richard W. Geller, MD
Gregory S. Germain, MD
Susan Glasser, MD
Dyan Griffin, MD
Marshall P. Grodofsky, MD
Richard C. Harvey, Jr., MD
Hillary S. Hernandez-Trujillo, MD
Elizabeth Herz, MD
Delbert H. Hodder, MD
Peter J. Jannuzzi, MD
Ishrat Quadri, MD
22
Pediatric Critical Care
The Division of Pediatric Critical Care is dedicated to the
delivery of state-of-the-art child and family centered care for
critically ill and injured children.
The division’s mission is accomplished by a collaborative
group that champions a multidisciplinary approach to care, the
incorporation of best available evidence into clinical practice,
and acquisition of new knowledge through clinical research.
Attention to patient safety, continuous performance improvement, and education of physicians, nurses, and other care
team members is paramount.
Major awards and academic accomplishments among the division members include important contributions to several national societies and both internal and external collaborations:
Dr. Christopher Carroll continues to be active in clinical and
translational research, collaborating with investigators at Connecticut Children’s, at Jackson Laboratories, and internationally. He continues in leadership roles in major medical organizations including:
Associate Editor of two journals: Chest and Journal of
Asthma
Serves as Chair of the Pediatric Network, Chair of the Scientific Presentation and Awards Committee, Executive
Committee of the Council of NetWorks, Member of the
Board of Trustees for the CHEST Foundation and Social
Media Editor of the American College of Chest Physicians
Appointment to the Program and the Planning Committee
of the American Thoracic Society
Appointment to the Multidisciplinary Critical Care Knowl
edge Assessment Program Committee and to the LearnICU
Committee of the Society of Critical Care Medicine
•
•
to children, educate Haitian health care personnel, and perform clinical research. He holds monthly videoconferences
concerning the care of neonates with residents and staff at
Justinien University Hospital in Cap-Haitian, Haiti. He also
continues to serve as the Membership Chairperson for the
American Academy of Pediatrics Section on International
Child Health, and as the SOICHPix Coordinator at the National Conference and Exposition.
Dr. Heather Schlott continues activities in the American College of Chest Physicians Pediatric Chest Medicine Network
Steering Committee. She also has been the division leader of
our extracorporeal membrane oxygenation (ECMO) program,
in partnership with Pediatric Surgery and Neonatology physician colleagues, as well as nursing, respiratory therapy, and
perfusion team members. This technology provides state-ofthe-art heart and lung support for our most critically ill and
injured patients. The program has grown and been extremely
successful, with outcomes that exceed national benchmarks.
She also led the development and implementation of our continuous renal replacement therapy (CRRT) program, which
has grown with excellent clinical results. These capabilities
are key components of modern PICU care and specifically
crucial to the expansion of our Cardiac Surgery program.
•
•
In further regard to the Cardiac Surgery program, Dr. Kenneth
Banasiak has taken a lead role in clinical, educational, and
performance improvement aspects of the multidisciplinary
process in collaboration with our Cardiology and Cardiac
Surgery colleagues. They are implementing clinical pathways
that will standardize and streamline the care of post-operative
patients. He is also creating a new Critical Care Physiology
course for pediatric residents.
Dr. Adam Silverman continues his leadership of our Global
Healthcare Initiative. The second annual Global Healthcare
Fair was held in May of 2014, and the first annual Global
Healthcare Film Festival was held in November of 2014. Locally, he continues to support the Global Healthcare Educational Pathway for pediatric residents and organizes the activities of Connecticut Children’s Medical Center staff members
who travel to developing countries to help improve the healthcare of children.
Dr. Daniel Fisher continues his work with colleagues in the
Divisions of Otolaryngology and Pediatric Surgery to hone
the activities of the Critical Airway Response Team, which
responds to life-threatening emergencies in children with upper airway obstruction. In addition, he continues his leadership in the refinement of the hospital’s recently implemented
comprehensive electronic medical record, which has a huge
impact on the quality of daily patient care, safety improvement,
and clinical research.
His efforts also have international impact. Each year, he coordinates multiple groups’ trips to Hospital Bernard Mevs in
Port-au-Prince, Haiti, where they directly render clinical care
Dr. Leonard Comeau continued his activities to improve the
comfort and quality of care for our patients, both in the PICU
23
Pediatric Critical Care
and hospital-wide. He is a leader of our developing comprehensive palliative care program. He participates in care delivered
by the Sedation Service, and also serves as the leader of the
quality and safety oversight activities of the Sedation and Analgesia Committee. He serves as the Chair of the hospital Ethics
Committee, which deals with issues related to the appropriateness and decision-making regarding health care for some of
our most complicated patients.
Dr. Allison Cowl continues her clinical research collaborations
with the Pediatric Acute Lung Injury and Sepsis Investigators
(PALISI) international network, focusing on various aspects
of the management of sedation and pain during the care of
critically ill children. She is implementing clinical research protocols spurred by results of a national multicenter study of
sedation practices in children with severe respiratory failure.
She implemented an Advanced Critical Care elective rotation in concert with a new national restructuring of education
framework for pediatric residents.
Drs. Rosanne Salonia and Aaron Zucker are among leaders
of a hospital-wide group that oversees an “early warning system” which focuses attention on patients at risk for clinical deterioration. Dr. Zucker is the Chairperson of the Peer Review
Committee, which oversees the Medical Staff’s evaluations
of individual physician’s clinical performance and patient outcomes in pursuit of the best and safest care for our patients.
blood pressure monitor with Orion/MaxIQ NIBP module.
Blood Pressure Monitoring. 2014;19(3):180-2.
Carroll CL, Ramachandran P. The intelligent use of digital tools and social media in practice management. Chest.
2014;145(4):896-902.
Carroll CL, Sala KA, Fisher D, Zucker AR. Pediatric code
events: does in-house intensivist coverage improve outcomes? Pediatr Crit Care. 2014;15(3):250-257.
STAFF
Aaron Zucker, MD
Division Head
Kenneth Banasiak, MD
Rosanne Salonia, MD
Christopher Carroll, MD
Heather Schlott, MD
Leonard Comeau, MD
Adam Silverman, MD
Allison Cowl, MD
Petronella Stoltz, APRN
Daniel Fisher, MD
PUBLICATIONS
Hymel KP, Armijo-Garcia V, Foster R, Frazier TN, Stoiko M,
Christie LM, Harper NS, Weeks K, Carroll CL, Hyden P, Sirotnak A, Truemper E, Ornstein AE, Ming Wang M. Validation of a
clinical prediction rule for pediatric abusive head trauma. Pediatrics. 2014;134:e1537-1544.
Gupta P, Tang X, Gossett JM, Gall CM, Lauer C, Rice TB,
Carroll CL, Kacmarek RM, Wetzel RC. Association of center
volume with outcomes in critically ill children with acute asthma: a multicenter analysis. Annals Allergy Asthma Immunol.
2014;113(1):42-47.
Carroll CL, Coro M, Cowl A, Sala K, Schramm CM. Transient
occult cardiotoxicity in children receiving continuous beta-agonist therapy. World J Pediatr. 2014;10(4):324-9.
Lang SM, Giuliano JS, Carroll CL, Eisenfeld L. Neonatal/
infant validations study of the CAS model 740 non-invasive
Dr. Adam Silverman at Hospital Bernard Mevs, Port-au-Prince, Haiti
24
Pediatric Dentistry
The Division of Pediatric Dentistry provides a full range of
primary and specialty dental services for children. Significant expertise is available in the areas of dentofacial growth
and development, craniofacial and dental anomalies and
pathology, behavior management associated with dental treatment delivery, dental care for children with special
health needs, prevention of dental diseases, and dental
public health issues affecting children.
Services available include restorative dentistry, surgical treatment of oral and perioral hard and soft tissue pathology, dental treatment with procedural sedation, oral rehabilitation under general anesthesia, and treatment of minor orthodontic
problems. The division provides quality oral health care in a
timely and caring manner. Emphasis is placed on assisting
other specialty divisions within Connecticut Children’s Medical
Center in managing their patients’ overall health care needs
by preventing and treating oral disease.
The division also is committed to supporting research activities consistent with the Connecticut Children’s and University
of Connecticut School of Dental Medicine institutional missions.
The division is currently comprised of 40 members of the dental staff, 28 active, 7 courtesy, and 5 consulting. There are 37
pediatric dentists, one orthodontist, one oral pathologist, and
one prosthodontist. Dr. Richard Skinner serves as the Director
of the Division of Pediatric Dentistry. During 2014, members
of the division completed 618 oral rehabilitation cases in the
operating rooms at Connecticut Children’s, representing a
26% increase over the number of cases completed last year.
The UConn School of Dental Medicine’s Division of Pediatric Dentistry, headed by Dr. Mina Mina, operates a full-service
dental clinic at Connecticut Children’s. The dental clinic is the
principle clinical site for the UConn School of Dental Medicine’s Advanced Education Residency Program in Pediatric
Dentistry. Dr. Bina Katechia serves as the Residency Program
Director, and Dr. Jorge Rabat is the Assistant Residency Program Director. Four residents completed the program in June
2014. All four of them challenged and successfully completed the Qualifying Examination of the American Board of Pediatric Dentistry (ABPD) that same month. All four residents
made presentations at the annual meeting of the American
Academy of Pediatric Dentistry in May 2014. The current
combined first- and second-year resident classes have a total
of 12 residents. This represents the culmination of our continued residency program expansion, facilitated by a 5-year
$1.8 million HRSA Title VII Grant. In 2014, the Connecticut
Children’s dental clinic provided 5,788 outpatient clinical visits.
Over 14,200 dental procedures were completed in the clinic,
and 88 oral rehabilitation cases were completed in the Connecticut Children’s operating rooms under general anesthesia. A total of 361 patients received procedural sedation during the delivery of dental services in the clinic.
The dental clinic also provides a site for the clinical education
of UConn Dental Students, UConn Advanced Education in
General Dentistry residents, Tunxis Community College Dental Hygiene students, Tunxis Community College Dental Assistant students, Prince Regional Vocational Technical School
Dental Assistant students, and Porter and Chester Dental Assistant students.
In addition to Drs. Katechia, Mina, Rabat and Skinner, three
full-time UConn Pediatric Dentistry faculty serve as attendings in the clinic, including Dr. Deborah Redford-Badwal, the
Dental Director of the Connecticut Children’s Craniofacial
Disorders Team. The clinic is additionally supported by 6 parttime UConn attending faculty. Oral Surgery support for the
clinic is provided by residents and attending faculty from the
UConn Oral and Maxillofacial Surgery Residency Program,
directed by Dr. David Shafer.
The following members of the division received a variety of
honors and accolades over the past year.
Drs. Monica Cipes and Richard Skinner continued to serve as
Consultants to the Examination Committee of the American
Board of Pediatric Dentistry.
Dr. Ira Greene was re-elected President of the Connecticut
Society of Pediatric Dentists.
PUBLICATIONS
Law CS, Douglass JM, Farman AG, White SC, Zeller GG,
Lurie AG, Goske MJ. The image gently in dentistry campaign:
partnering with parents to promote the responsible use of Xrays in pediatric dentistry. Pediatr Dent. 2014;36(7):458-9.
Sagomonyants K, Mina M. Stage-specific effects of fibroblast growth factor 2 on the differentiation of dental
pulp cells. Cells Tissues Organs. 2014;199(5-6):311-28.
25
Pediatric Dentistry
doi:10.1159/000371343. Epub 2015 Mar 25.
STAFF
Sagomonyants K, Mina M. Biphasic effects of FGF2 on
odontoblast differentiation involve changes in the BMP and
Wnt signaling pathways. Connect Tissue Res. 2014 Aug;55
Suppl 1:53-6. doi:10.3109/03008207.2014.923867.
Richard Skinner, DMD
Division Head
Mirucki CS, Abedi M, Jiang J, Zhu Q, Wang Y-H, Safavi KE,
Clark RB, Nichols FC. Biological activity of Porphyromonas
endodontalis complex lipids. J Endod. 2014;40(9):1342-8.
PMID: 25146013.
Cristian Brutten, DDS
Jorge Rabat, DDS
Joanna
Douglass, BDS, DDS
Deborah
Redford-Badwal, DDS, PhD
Ira Greene, DDS
Moises Y. Salas, DDS, MPH
Bina Katechia, DDS, MSc
Cristina Santos-Tomas, DDS
Glenn Koehler, DDS
Gary Schulman, DDS
Mina Mina, DMD, MSD, PhD
Yu-Hsiung Wang, DDS, PhD
Lawrence Lee, DDS
Paulete Chung, RDH
Antonio Lepore, Jr, DDS
26
Developmental &
Rehabilitation Medicine
The division’s mission is: 1) to provide comprehensive and
compassionate diagnosis and management for children
with neurodevelopmental and behavioral problems that
range from normative deviations to rare disorders; 2) to
teach healthcare professionals about these problems; 3) to
add to existing knowledge by researching relevant questions in the field; and, 4) to offer advocacy and to support
public policy development.
The Division of Developmental and Rehabilitation Medicine
is composed of a diverse faculty - Developmental-Behavioral
Pediatrics (DBPeds) and Physical Medicine and Rehabilitation (PM&R) – who practice at a number of sites throughout
the state.
NEW STAFF
Developmental-Behavioral Pediatrician Thyde Dumont-Mathieu, MD, joined the division August 1, 2014. She brings 15
years experience and particular interests in autism and health
care access disparities. She has long-term research relationships with the Psychology Department at UConn (Storrs), and
this has been a beautiful fit to support the division’s autism
research collaboration with UConn Health Center (Farmington) and the Jackson Laboratories. In addition to her Developmental Pediatrics practice, she has assumed leadership for
the Comprehensive Down Syndrome Program. This provides
consultation to primary care providers, pediatric subspecialists, and families on the overall health and developmental
needs of children with Down syndrome.
Division clinical services occur in a number of settings – outpatient, inpatient, and community-based (e.g., schools, CT
Birth to Three system, and other agencies). We provide direct
consultation and clinical care.
The division has focused extensive resources on developing the Autism Spectrum Assessment Program (“ASAP”).
We have established a collaboration between DBPeds and
Neurology (i.e. the “Neurogenetics ASAP program”) that provides a direct line from the autism diagnosis in DBPeds to
standard-of-care clinical and laboratory evaluation. This also
provides access for all patients to our research collaborations.
GOALS FOR 2015
• Recruit a second pediatric physiatrist to support expand•
•
•
•
ing the inpatient service, as well as the clinics at satellite
locations
Pursue CARF (the Commission on Accreditation of Rehabilitation Facilities) accreditation for the Rehabilitation
Service
Seek funding for CBIF (Connecticut Bioscience Innovation
Fund) genetics grant, the goal of which is to assess whether the “AllSeq” platform is a good mechanism for bringing
additional genetic insights into clinical practice for people
with autism
Possible research collaboration on autism and breastfeeding – Ruth Lucas, PhD
Collaborate with the sedation team to help children with
autism and other developmental disabilities to prepare for
medical procedures. This will have organization-wide impact and has “standard of care”-altering potential.
The division’s research includes:
Early Detection of Pervasive Developmental Disorders. PI:
Fein, D. Co-Investigators: Barton M, Green J, Dumont-Mathieu T, Stone W, and Robins D. April 1, 2009 thru March
31, 2014. Funded by: the National Institute of Child Health
& Human Development
Multidisciplinary “ARC” initiative between CT Children’s
Medical Center, UConn Health Center and the Jackson
Laboratory: Neuronal Synaptic and Circuit Dysfunction in
the Autism Spectrum Disorders. Dr. Milanese is one of the
principal investigators. 2013-2018. Funded by: Institute for
Systems Genomics
•
•
PUBLICATIONS
Herlihy LE, Brooks B, Dumont-Mathieu T, Barton ML, Fein
D, Chen Chi-Ming, Robins DL. Standardized screening facilitates timely diagnosis of autism spectrum disorders in a diverse sample of low-risk toddlers. J Dev Behav Pediatr. 2014
Feb-Mar; 35(2):85-164,S1-S15.
O’Brien JE, Dumas HM, Nash CM, Burke SA, Holson DC,
Mast J, Pelegano J, Simpser EF, Traul C, Whitford K. Pediatric post-acute care hospital transitions: an evaluation of
current practice. Hosp Pediatr. 2014 Jul;4(4):217-21. doi:
10.1542/hpeds.2013-0105.
27
Developmental &
Rehabilitation Medicine
Robins DL, Casagrande K, Barton ML, Chen C, DumontMathieu T, Fein D. Validation of the Modified Checklist for
Autism in Toddlers 2014 – revised with follow-up (M-CHATR/F). Pediatrics. 2014.
FACULTY
Ann Milanese, MD
Division Head
Mark Greenstein, MD
Paul Dworkin, MD
Edwin Cruz-Zeno, MD
John Pelegano, MD
Thyde Dumont-Mathieu, MD
Sarah Schlegel, MD
28
Digestive Diseases,
Hepatology, & Nutrition
The Division of Digestive Diseases, Hepatology, and Nutrition is committed to cutting edge and innovative clinical
care of infants, children and adolescents, pioneering clinical, translational, and basic research, and the education of
the next generation of physicians.
dents who spend three years receiving their sub-specialty
training. The great depth in our pediatric surgical and radiology programs as well as the great variety of clinical disorders and the intimate involvement of our faculty in education
makes our fellowship program particularly attractive.
In 2014, the division, small by the standards of other children’s
hospitals, was a leader on both the national and international
stages. Our Center for Pediatric Inflammatory Bowel Disease,
the largest program in the region between Boston and New
York, currently provides care to over 600 children with Crohn’s
disease and ulcerative colitis. We are the Clinical Coordinating
Center for a $10.4 million grant from the National Institutes
of Health to lead the PROTECT Study: Predicting Response
to Standardized Pediatric Colitis Therapy. This five-year effort
coordinates the resources of 28 leading pediatric IBD centers in North America to study newly diagnosed children with
ulcerative colitis. PROTECT, along with the Crohn’s and Colitis Foundation of America (CCFA) RISK stratification study
of 1,200 newly diagnosed children with Crohn’s disease,
has squarely placed Connecticut Children’s at the epicenter
of pioneering research in pediatric inflammatory bowel disease. We commenced formal collaborative work with Jackson
Laboratories to isolate and study intestinal stem cells from
children with inflammatory bowel disease. Dr. Wael Sayej of
the division has also entered into collaboration with Jackson
Laboratories to study esophageal stem cells as part of his
work in elucidating the mechanisms of disease in eosinophilic
esophagitis. Dr. Zev Davidovics has directed our fecal transplant team for the treatment of refractory Clostridium difficile
infection.
Dr. Jeffrey Hyams, Division Head, was the winner of the American Academy of Pediatrics 2014 Murray Davidson Award.
Our Multi-disciplinary Intestinal Rehabilitation Team (IRT) is
the only one of its kind in the state. Co-directed by Drs. Karan
Emerick and Zev Davidovics, this group focuses on the care
of children with intestinal failure of all causes.
Our Center for Pediatric Liver Care, directed by Dr. Karan
Emerick, provides care to children with a large range of hepatic disorders ranging from chronic hepatitis B and C, metabolic liver disease, non-alcoholic fatty liver disease (NAFLD),
autoimmune disease, and acute and chronic liver failure. It
provides pre- and post-transplant care to 40 children.
Our fellowship program under Dr. Sayej has benefited from
the recruitment of highly qualified graduating pediatric resi-
PUBLICATIONS
Walters TD, Kim M, Denson LA, Griffiths AM, Dubinsky M,
Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn
M, Otley A, Heyman MB, Leleiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, OlivaHemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S,
Liu C, Essers J, Kugathasan S, Hyams JS. Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs
an immunomodulator in children with Crohn’s disease. Gastroenterology. 2014;146:383-91.
Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van
Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour
M, Morgan XC, Kostic AD, Luo C, González A, McDonald D,
Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F,
Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight
R, Xavier RJ. The treatment-naive microbiome in new-onset
Crohn’s disease. Cell Host Microbe. 2014;15:382-92.
Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME,
Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz
J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM,
Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of
neutrophil Fcγ receptor I (CD64) index as a biomarker for
mucosal inflammation in pediatric Crohn’s disease. Inflamm
Bowel Dis. 2014;20:1037-48.
Hyams JS. Standardized recording of parameters related to
the natural history of inflammatory bowel disease: from Montreal to Paris. Dig Dis. 2014;32:337-44.
Sunseri W, Hyams JS, Lerer T, Mack DR, Griffiths AM, Otley AR, Rosh JR, Carvalho R, Grossman AB, Cabrera J, Pfefferkorn MD, Rick J, Leleiko NS, Hitch MC, Oliva-Hemker
M, Saeed SA, Kappelman M, Markowitz J, Keljo DJ; Pediatric Inflammatory Bowel Disease Collaborative Research
29
Digestive Diseases,
Hepatology, & Nutrition
Group. Retrospective cohort study of methotrexate use in the
treatment of pediatric Crohn’s disease. Inflamm Bowel Dis.
2014;20:1341-5.
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns
R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman
MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD,
Aronow B, Xavier RJ, Gevers D, Denson LA. Pediatric Crohn’s
disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2014;124:3617-33.
Hyams JS. Biologics in pediatric Crohn’s disease: is it time
to move to an earlier therapeutic approach? Expert Rev Clin
Immunol. 2014;10:1423-6.
Walters TD, Hyams JS. Can early anti-TNF-α treatment be
an effective therapeutic strategy in children with Crohn’s disease? Immunotherapy. 2014;6:799-802.
Rosh JR, Hyams JS. Pediatric UC drug development: a
GREAT idea now needs a GRAND conversation. J Pediatr
Gastroenterol Nutr. 2014;58:677-8.
Arbuckle RA, Carson RT, Abetz-Webb L, Hyams J, Di Lorenzo C, Lewis BE, Gargon E, Kurtz C, Shiff SJ, Johnston JM.
Measuring the symptoms of pediatric constipation and irritable bowel syndrome with constipation: expert commentary
and literature review. Patient. 2014;7:343-64.
Zeisler B, Hyams J. Transition of management in adolescents
with IBD. Nat Rev Gastroenterol Hepatol. 2014;11:109-15.
BOOK CHAPTERS
Zeisler B, Sylvester FA. Protein losing enteropathy. In: Practical algorithms in pediatric gasteroenterology. Shaoul R, editor.
(Practical algorithms in pediatrics. Hochberg Z, series editor.)
Haifa; 2014.
Zeisler B, Sylvester FA. Gasterointestinal polyps. In: Practical algorithms in pediatric gasteroenterology. Shaoul R, editor.
(Practical algorithms in pediatrics. Hochberg Z, series editor.)
Haifa; 2014.
Hyams J. The natural history of ulcerative colitis. In: Pediatric
inflammatory bowel disease. 2nd ed. New York: Springer.
STAFF
Jeffrey Hyams, MD
Division Head
Zev Davidovics, MD
Karan Emerick, MD
Franziska Mohr, MD
Wael Sayej, MD
Francisco Sylvester, MD
Bella Zeisler, MD
Donna Zeiter, MD
Kristin Phillip, APRN
Heidi Sweeney, APRN
30
Emergency Medicine
The Division of Emergency Medicine is committed to a
continuous quality improvement process, and we have improved our efficiency, the safety of our healthcare delivery
system and ultimately our patient satisfaction.
In 2014, the Emergency Department of Connecticut Children’s Medical Center treated 56,998 patients, our highest
annual volume ever. Although the rate of growth has slowed
since 2010, this represents a 30% increase over the last 10
years. The greatest clinical challenge continues to be the increasing number of behavioral/mental health patients. In response to the serious safety issues raised by some of these
patients, the Emergency Department underwent a partial redesign and renovation of some physical space. Eleven rooms
were built in a sequentially securable area that incorporates
safety design features, such as anti-ligature door handles and
bathroom features. Seven of them were designed to be convertible to accommodate the evaluation of medical patients
with the ability to secure medical equipment behind a garage
type door. Security presence has been augmented with expanded coverage by an assigned security officer and an ED
Safety Officer. The addition of an ED social worker who evaluates low risk patients has decreased the average length of
stay for our behavioral health patients.
Solutions to the behavior/mental health crisis extend beyond
Connecticut Children’s Medical Center. Dr. Steve Rogers,
Emergency Mental Health and Psychiatric Services Coordinator for the division, has been partnering with DCF and Behavioral Health Partners to entrain other state resources. Dr.
John Peng served on the Connecticut Hospital Association’s
Subcommittee for Mental Health to develop recommendations to the state legislature to improve health outcomes and
reduce unnecessary use of the emergency department.
In April of 2014, we went live with a new electronic medical
record. Implementation was successful with return to baseline key process indicators within 4 weeks despite a record
patient volume during that month. Other initiatives include an
Excellence Delivered campaign to reinforce service behaviors
to improve the patient experience and satisfaction. As part
of the drive to improve efficiency, direct bedding was implemented. This has decreased our arrival-to-provider time. Pathways for asthma and gastroenteritis/dehydration were implemented. Improving our time metrics in the treatment of sepsis
has been a focus with the development of a sepsis alert and
standardized approach.
Our faculty has been joined by Eric Hoppa, MD, a former
resident of the University of Connecticut pediatric residency
program who completed a fellowship in pediatric emergency
medicine at Boston Children’s Hospital. Dr Hoppa worked
for several years as an attending physician at Cohen Children’s Medical Center and also served as Director of Pediatric Emergency Medicine at one of their community affiliates.
We have also had the addition of 3 physician assistants: Lisa
Tryon PA-C, Leila Rebai, PA-C, and Lauren Christofori, PA-C.
Carol Erickson, APRN, has taken over the leadership role for
the advanced practitioners. Members of the Division of Emergency Medicine continue to be highly involved in leadership
and committees at Connecticut Children’s with participation
by the division in over 35 hospital committees. Dr. Jim Parker
is the Chairperson for EMS-C for the State of Connecticut
and vice chair of the North Central Region Medical Advisory
Council. Dr. Michael Soltis serves on the state’s Child Fatality panel and the Abusive Head Trauma working group. On
a regional and national level, Dr. Steven Rogers completed a
3-year term as the American Academy of Pediatrics Chair of
the Committee for the Future for the Section on Emergency
Medicine. He continues to serve on the Executive Board of
the Eastern Society for Pediatric Research and as the program chairperson for the Injury Free Coalition for Kids. He
also continues to be on the editorial boards and act as a reviewer for multiple journals and national conferences.
Education and research continue to be part of our mission.
The faculty taught and mentored pediatric residents, emergency medicine residents, family practice residents, medical
students, dental students and advanced practitioner students.
Under the leadership of Dr. John Brancato, who also functions as associate division head, our fellowship program has
continued to successfully recruit talented fellows. Dr. Matt
Laurich has undertaken the associate fellowship director
position. An undergraduate research assistant program that
was developed by Dr. Sharon Smith and taught by our faculty
supports the research productivity of our division. Research
projects covering topics such as violence prevention, appendicitis, ultrasound-guided IV placement, lethal means restriction,
nutrition and asthma are ongoing. Dr. Smith is also the Director of PALS for the institution.
The Trauma program underwent a successful re-verification
by the American College of Surgeons for designation as a
Level 1 Pediatric Trauma Center. The Emergency Department
31
Emergency Medicine
is seeking to have all Level I Trauma patients be transported
to and evaluated directly at Connecticut Children’s. Dr. Parker
is Medical Director of the Transport program, which is planning to transition to a nurse-led team. They have acquired a
Connecticut Children’s ambulance cobranded with AMR and
will be building another medical transport vehicle.
ioral health patients in the pediatric emergency department.
J Trauma Acute Care Surg. 2014 Oct;77(3 Suppl 1):S23-8.
Two of our staff members were the recipients of notable
awards. Eric Hoppa received the McNeill Teaching Award
from the Pediatric Residents for November 2014. Lana Friedman was given the Pediatric Emergency Medicine Teaching
Award from the Department of Emergency Medicine at Hartford Hospital in June of 2014.
Kohn C, Saleheen H, Borrup K, Rogers S, Lapidus G. Correlates of drugs use and driving among undergraduate college students. Traffic Inj Prev. 2014;15(2):119-24.
PUBLICATIONS
Sturm JJ, Hirsh D, Weselman B, Simon HK. Reconnecting
patients with their primary care provider: an intervention for
reducing nonurgent pediatric emergency department visits.
Clin Pediatr. 2014.
Rogers SC, DiVietro S, Brinkley A, Kaminer Y, Lapidus G.
Restricting youth suicide: a pilot descriptive study of behav-
Rogers SC, Chun TH. Flood of pediatric mental health patients strains emergency department resources. AAP NEWS.
2014;35(6):1.
Chicaiza H, Hellstrand K, Lerer T, Smith SR*, Sylvester F.
Potassium hydroxide: an alternative reagent to perform the
Modified Apt Test. J Peds. 2014 Sep;165(3):628-30.
32
Emergency Medicine
BOOK CHAPTERS
PEER-REVIEWED E-PUBLICATION
Rogers SC, Cohen-Abbo A. Mononucleosis. In: Rosen &
Barkin’s 5-minute emergency medicine consult. 5th ed. Wolters Kluer; 2014. p. 714-5.
Sherman JM, Sheppard P, Hoppa E, Krief W, Avarello J. Let
us use LET: a quality improvement initiative. Pediatr Emerg
Care. 2014 Dec 3. [Epub ahead of print]
Per Diem Attending
Kay Hesse, MD
PA/APRN
Ann Gorjanc, PA
Sandra Johnson, MD
Gary Lapidus, PA-C, MPH
Seth Lotterman, MD
Josh Freund, PA-C
Sarah Orlando, PA
Zoe Casey, MD
Pediatricians
Christine Cornachio, MD
Lana Friedman, MD
David Marcello, MD
Andrew Heggland, MD
Marissa Smith, MD
Christopher
Scheinberg, APRN
Eric Hoppa, MD, FAAP
Sarah-Jo Stimpson, MD
Meg Seitz, PA-C, MS
Matt Laurich, MD
Per Diem Pediatricians
Brenda Balch, MD
Lauren Christofori, PA-C
STAFF
Attendings
John Peng, MD
Division Head
John Brancato, MD
James Parker, MD
Carla Pruden, MD
Steven Rogers, MD
Michael Soltis, MD
Adam Silverman, MD
Sharon Smith, MD
Jesse Sturm, MD
Kristin Welch, MD
James Wiley II, MD
Meredith Barrows, MD
Glenda Nouman, DO
Charles Thompson, MD
Kate Pesce, APRN
Carol Erickson, APRN
Leila Rebai, PAC, MS
Lisa Tryon, PA
Nancy Trout, MD
Per Diem PA/APRN
Keri McGeary, PA-C
Elizabeth Smith, MD
Kathleen O’Leary, APRN
Richard Pierce, MD
Dave Parrotti, PA
Nicole Frost, APRN
33
Pediatric Endocrinology & Diabetes
The division was recognized by the U.S. News Media Group
(U.S. News & World Report) again in 2014 as one of the
top programs in the country for endocrinology and diabetes.
Our Diabetes Education Program was reaccredited by the
American Association of Diabetes Educators, one of only
three programs certified in Connecticut in 2014, and the
only one dedicated to the care of children and adolescents
with diabetes. This attests to the high quality and standards
that our staff of diabetes educators, including registered dietitians, nurse, social worker, nurse practitioners and physicians under the able leadership of Dr. Cem Demirci provide
to over 1,200 children with type 1 and type 2 diabetes and
their families.
With the growth of faculty, staff and clinical programs over
the past several years, the division’s space challenges were
completely met by our relocation to the new Connecticut
Children’s Medical/Surgical Center at 505 Farmington Avenue in Farmington, CT, in September 2014. Our new clinical
area now offers bright, colorful, comfortable patient and family rooms for our out-patient programs, 10 large examination
rooms, and adequate offices and conference space for faculty, staff, fellows, residents, and medical students. Our patients
and families especially appreciate easy access and parking
as well as the welcoming environment created by a larger
waiting area where art created by local school children decorates the walls. While the primary home of the division is now
in Farmington, the division continues to care for hospitalized
patients on the Hartford campus of Connecticut Children’s
Medical Center and at our office at 85 Seymour Street for
children who are enrolled in our weight management program
and families with limited ability to travel to Farmington.
This year has brought a number of changes in the leadership
of the division. Dr. Karen Rubin stepped away from her position as division head (2008-2014), while remaining clinically
active in the division, in order to devote the majority of her
efforts to expanded departmental roles as Associate Chair
for Clinical Affairs and a new appointment as the Chief Innovation Officer at Connecticut Children’s. Dr. Susan Ratzan,
a founding member of the division and former division head,
was named interim division head while a national search for
a new division head was announced on October 1, 2014. Dr.
Paola Palma Sisto was named Clinical Director, a formal leadership role in the new alignment of divisions and restructuring
of Connecticut Children’s Specialty Group. Dr. Elizabeth Es-
trada was promoted to Professor of Pediatrics, University of
Connecticut School of Medicine. She has been the Director
of the Pediatric Obesity Center for Treatment, Research and
Education, and a valued member of the division for 18 years.
She and her husband, Dr. Francisco Sylvester, Division of Digestive Diseases, Hepatology & Nutrition, were co-recruited
to join the faculty of the Department of Pediatrics at the University of North Carolina, and we are grateful for their years of
contributions to Connecticut Children’s Medical Center.
Our fellowship training program has successfully recruited
well-qualified trainees each year and all graduates have
moved on to clinical academic positions. Dr. Palma Sisto assumed the Directorship of the Pediatric Endocrine Fellowship
with the departure of Dr. Estrada. Dr. Palma Sisto also is the
Director of Fellowships for the Department of Pediatrics, overseeing 6 medical to assure that all fellowships at Connecticut
Children’s meet ACGME requirements.
Division members provide leadership in a number of clinical and research collaborations including the following: Drs.
Rubin and Palma Sisto co-direct the Thyroid Center, a multidisciplinary, coordinated program with Surgery, Radiology,
Pathology, and Nuclear Medicine for the evaluation and treatment of children with thyroid nodules and thyroid cancer. Dr.
Riba-Wolman directs the Endocrine Late Effects Clinical Program in the monthly STAR program in the Oncology division
for long-term survivors of childhood cancer. Dr. Priya Phulwani
is the Endocrine Director of the multidisciplinary (Genetics,
Urology, Psychiatry) program for youth with disorders of sexual development and gender dysphoria. Melissa Santos, PhD,
Clinical Director of the Pediatric Obesity Center, received a
CICATS Pre-K award to support her development in clinical
and translational obesity research. She is collaborating with
Jackson Labs at the University of Connecticut Health Center
on a proposed study of the epigenetics of obesity. Dr. Nancy
Dunbar, in addition to directing our Bone Health Program, is a
member of the I-91 Global Health Group and volunteered in
Haiti through the non-profit organization, Crudem, to develop
a pediatric diabetes program and provide endocrine consultation to a local pediatrician. The program now supports 30
Haitian children with diabetes including medical and surgical
care, insulin, and other diabetes supplies. Dr. Christine Trapp is
enrolled in the Masters in Clinical and Translational Research
at the University of Connecticut Health Center to gain additional skills to support her research in obesity prevention
under the mentorship of Dr. Michele Cloutier.
34
Pediatric Endocrinology & Diabetes
STAFF
The division is looking forward to our full integration into Care
Navigator (EHR) for our ambulatory practice in the fall of
2015. Our Physician Builder, Dr. Rebecca Riba-Wolman, has
worked tirelessly with the Care Navigator team and members
of the division to ensure that our specific practice and clinical
goals will be achieved and our transition a smooth one.
Susan Ratzan, MD
Interim Division Head (10/1/14 - )
PUBLICATIONS
Cem Demirci, MD
Alvarez-Perez JC, Ernst S, Demirci C, Casinelli GP, MelladoGil JM, Rausell-Palamos F, et al. Hepatocyte Growth Factor/
c-Met Signaling is required for β-cell regeneration. Diabetes.
2014; 63(1):216-23.
Nancy Dunbar, MD
Karen Rubin, MD
Division Head (1/1/14 – 9/30/14)
Elizabeth Estrada, MD
(through October 2014)
Nilsson O, Guo MH, Dunbar N, Popovic J, Flynn D, Jacobsen
C, et al. Short stature, accelerated bone maturation and early
growth cessation due to heterozygous aggrecan mutations. J
Clin Endocrine Metab. 2014:99(8):E1510-8.
Paola Palma Sisto, MD
Estrada E, Eneli I, Hampl S, Mietus-Snyder M, Mirza N,
Rhodes E, et al. Children’s Hospital Association Consensus
statements for co-morbidities of childhood obesity. Child
Obes. 2014 Aug.
Christine Trapp, MD
Haemer M, Grow H, Fernandez C, Lukasiewicz G, Rhodes E,
Shaffer L, Sweeney B, Woolford S, Estrada E. Addressing
prediabetes and type 2 diabetes in childhood obesity treatment: summary of research and current practice. Child Obes.
2014 Aug.
Palma Sisto PA, Heneghan MK. Endocrinology. In: Marcdante K, Kliegman RM, Behrman RE, editors. Nelson’s essentials of pediatrics. 7th edition. Philadelphia: WB Saunders;
2014.
Rubin K. Optimizing management of patients with Turner
syndrome in transition to adulthood and corresponding Q&A
assessment. American College of Endocrinology Self-Assessment Program in Endocrinology and Metabolism (ASAP),
2014.
Priya Phulwani, MD
Rebecca Riba-Wolman, MD
Melissa Santos, PhD
Karen Bucci, APRN
Nancy Paulhus-Orkin, APRN
35
General Pediatrics
The Division of General Pediatrics is committed to fostering
the health and well-being of children, families and communities.
To realize this mission, we provide exceptional clinical care in
partnership with families, teach evidence-based clinical pediatrics to the next generation of pediatric health care providers,
and pursue original research and vigorous advocacy around
issues important to children, families and the public. All of our
activities place special emphasis on caring for children with
special health care needs, including disadvantaged children,
children growing up in low-income families, and children with
complex and chronic medical conditions.
The Division of General Pediatrics continues to provide
the majority of pediatric primary care to Hartford’s children
through the ambulatory and primary care clinics at Connecticut Children’s Medical Center, Saint Francis Hospital and
Medical Center, and the Burgdorf/Bank of America Health
Center. Members of the division provide ambulatory care to
infants, children and adolescents, and inpatient care for newborns and children with lead poisoning and suspected abuse
or neglect. Our ambulatory services include health supervision, behavioral health care, chronic disease management,
and urgent care using a Medical Home model. The division
houses innovative, community-wide clinical programs such as
the Hartford Regional Lead Treatment Center, the Reach Out
and Read literacy program, and the Suspected Child Abuse
and Neglect (SCAN) program. Under the direction of Nina
Livingston, MD, the SCAN program provides medical and social work diagnostic consultations for concerns of child abuse
and neglect to all Connecticut Children’s inpatient services.
Outpatient and telephone consultations also are available
when there is concern for possible child abuse or neglect. Division faculty have gained regional and national prominence
for clinical research, education, and program development in
the fields of injury epidemiology and prevention, child behavior
and development, culturally effective health care, emergent
literacy promotion and development of Medical Home-based
systems of care for children and youth with special health
care needs.
The largest clinical site of the division, the Primary Care Center at Connecticut Children’s, moved to a new site in April
2014. This new larger, community-based center, located ½
mile from the medical center, is more accessible to the Cen-
ter’s patients and has been designed to better accommodate
electronic medical records, and to enhance operational flow
and capacity. In 2014, the division also successfully recruited
three new faculty members; the division’s first Adolescent
Medicine subspecialist, Dr. Nancy Miller, and Dr. Patricia Garcia, to the Primary Care Center at Connecticut Children’s
Medical Center, and Dr. Norrell Atkinson to the SCAN program. The year 2014 was also marked by the retirement of
Dr. Frederick Bogin, Medical Director of the Pediatric Clinic
at St. Francis Hospital and Medical Center, and Dr. Chitraleka
Ramanan, former director of the Pediatric Clinic at the University of Connecticut Health Center. Drs. Bogin and Ramanan
each spent more than 30 years caring for the underserved
children of Connecticut and training the next generation of
pediatricians.
Faculty members at division sites play a central role in education in the University of Connecticut system by providing
the majority of pediatric primary care and newborn nursery
educational experiences for medical students and residents
in the region. Other rotating learners from UConn and other
institutions include dental residents, child psychiatry fellows,
and students from nurse practitioner, physician assistant and
medical assistant programs. Members of the SCAN program
also are highly involved in educational efforts within the UConn system, including required and elective resident rotations,
lectures, Grand Rounds, and community provider education.
Division members serve on a wide variety of hospital, university and state committees. Membership on national committees includes the National Center for Culture Competence
Advisory Group (Alberto Cohen-Abbo, MD) and the Society
for Pediatric Dermatology Education Committee (Keri Wallace, MD). Research interests in the division include health
literacy, cultural competence, immunization, obesity, and quality of life measures in children. Division members collaborate
in the Asthma Center’s Easy Breathing© program, the Steps
to Growing Up Healthy study (obesity prevention for 2- to
4-year-olds) and the co-management pilot protocols with
Connecticut Children’s Medical Center pediatric subspecialists.
Patricia Joyce, MD, continues her work with the REACH
(Resident Education in Advocacy and Community Health)
pathway and community/advocacy education for all residents, working in collaboration with Connecticut Childrens’
Office for Community Child Health and its Office of Govern-
36
General Pediatrics
ment Relations, as well as the Center for Children’s Advocacy,
Connecticut Voices for Children, Office of the Child Advocate,
Help Me Grow, the Hartford Department of Health and Human Services, Child Health Development Institute, and the
Department of Children and Families. Residents enrolled in
the REACH pathway completed a Resident CATCH Grant
funded project called Healthy Habits for Healthy Hartford
Children. Dr. Wiley continues her advocacy work in the area
of emergent literacy and serves as Medical Director of Reach
Out and Read Connecticut. Melissa Held, MD, and Patricia
Joyce, MD, continue to modify aspects of the Ambulatory Pediatrics Clerkship to further improve upon this highly regarded
experience. Through the use of brief structured clinical observations during the clerkship, every medical student is directly observed and receives feedback from a faculty member
about his or her clinical skills a minimum of six times.
STAFF
Dr. Anton Alerte continues to serve as Director of UConn’s
Clinical Medicine course, and has established a new program
for fourth year students focused on their teaching skills. He
also continues in his roles as Vice President of the CT Chapter of the American Academy of Pediatrics and Chair of the
Chapter’s Committee on Foster, Kinship and Adoption Care.
This committee received a grant from the AAP in 2014 to
improve collaboration between practitioners and DCF in the
state. Grael O’Brien, MD, serves as site director for the CORNET (Continuity Clinic Research Network) of the Academic
Pediatric Association. This year she received a grant from the
CDC in support of an Adolescent Reproductive Health Care
Training Project.
Jennifer Haile, MD
PUBLICATIONS
Grael O’Brien, MD
Rogers S, Cohen-Abbo A. Mononucleosis. In: Schaider J, et
al, editors. Rosen & Barkin’s 5-minute emergency medicine
consult. 5th ed. Wolters Kluwer; 2014.
Catherine Wiley, MD
Division Head
Anton Alerte, MD
Chitraleka Ramanan, MD
Norrell Atkinson, MD
(SCAN)
Laurie Scheiner, MD
Frederick Bogin, MD
Christina Cefaloni, MD
Alberto Cohen-Abbo, MD
Patricia Garcia, MD
Susan Glasser, MD
Patricia Joyce, MD
Jaye Ladinsky, MD
Molly Senn-McNally, MD
Hilda Slivka, MD
Elizabeth C. Smith, MD
Jody Terranova, DO
Nancy Trout, MD
Keri Wallace, MD
Jessica Zimmerman, MD
Darlene Abbate, APRN
Dorien Barnett, APRN
Nina Stuart
Livingston, MD, FAAP
Meredith Brown, PA-C
Margaret
McLaren, MD, MB. BCh
Monica
Joyce-Montaudy, APRN
Lisa Menillo, MD
Kathleen Laurie
Kelliher, PA-C
Joseph Newell, MD
Priscilla Malloy, APRN
Dianne Powers, APRN
37
Pediatric General & Thoracic Surgery
The mission of the Pediatric General and Thoracic Surgery
Division is to provide the highest quality, family centered
surgical care. One new initiative implemented this year is
rapid access to our clinics with same-day appointments for
urgent conditions.
EXPANSION
The Division of Pediatric General and Thoracic Surgery performs a full range of clinical services for patients from newborns to young adults, and includes prenatal consults, the
treatment of congenital anomalies, enteral access, pediatric
gynecology, and surgical oncology. Connecticut Children’s is
an American College of Surgeons-verified Level I Pediatric
Trauma Center. We currently have satellite offices in Farmington and Danbury, and we are performing surgeries at the
Ambulatory Surgery Center in Farmington.
The mission of the division is to continue to provide the highest quality of care for children in Connecticut. This includes
easy patient access for subspecialty consultation as well as
enhancing care of children through innovative surgical techniques and instrumentation. This year we performed the first
two gastric sleeves for the treatment of adolescent obesity.
This procedure is used for those adolescents with severe
obesity and will complement the laparoscopic band procedure for obesity treatment.
EXCITING INITIATIVES: QUALITY IMPROVEMENT &
MULTIDISCIPLINARY PROGRAMS
Connecticut Children’s continues to be involved in the American College of Surgeons’ Pediatric National Surgical Quality
Improvement Program (NSQIP), which is the first multi-specialty program designed to measure and improve the quality
38
Pediatric General & Thoracic Surgery
of children’s surgical care. Dr. Brendan Campbell is the Surgeon Champion for the NSQIP Program, and over this past
year, implementation of a standardized pathway for appendicitis was accomplished.
STAFF
The Division of Pediatric General & Thoracic Surgery continues to drive several multi-disciplinary services aimed at facilitating and improving patient care and experience. Through the
Multidisciplinary Thyroid Group, children with thyroid diseases
are able to be evaluated simultaneously by a surgeon as well
as an endocrinologist. Over this past year, the team has evaluated over 48 patients with a wide range of thyroid pathology.
Michael Bourque, MD, FACS
PUBLICATIONS
Sherry Blair, APRN
Mondrinos MJ, Jones PL, Finck CM, Lelkes PI. Engineering
de novo assembly of fetal pulmonary organoids. Tissue Eng
Part A. 2014 Nov;20(21-22):2892-907.
Nicole Boone, PA
Vadasz S, Jensen T, Moncada C, Girard E, Zhang F, Blanchette
A, Finck C. Mid to late gestational age amniotic fluid stem cells
and lung bioengineering. J Pediatr Surg. 2014;49(11)155463.
Kelly Henri, APRN
Finck CM, Jensen T. Bioengineering distal airways. Stem
cells, tissue engineering and regenerative medicine. Elsevier;
2014. pp. 353-72.
Abby Theriaque, APRN
Campbell BT, Herbst KW, Briden KE, Neff S, Ruscher KA,
Hagadorn JI. Inhaled nitric oxide use in neonates with congenital diaphragmatic hernia. Pediatrics. 2014;134:e420e426.
Mazotas I, Toal M, Borrup K, Saleheen H, Hester AL, Copeland
D, Danielson PD, DeRoss A, Lapidus G, Bentley G, Thaker S,
Campbell BT. A prospective, multi-institutional study of pediatric all-terrain vehicle crashes. J Trauma Acute Care Surg.
2014;77:103-8.
Markush D, Briden KE, Chung M, Herbst KW, Lerer TJ, Neff S,
Wu AC, Campbell BT. Effect of surgical subspecialty training on patent ductus arteriosus ligation outcomes. Pediatr
Surg Int. 2014;30:503-9.
Misra MV, Tsai A, Valdez T, Campbell BT. Thoracoscopic
resection of a bronchogenic cyst located at the thoracic inlet.
J Laparoendosc Adv Surg Tech B, Videoscopy. 2014 Nov.
Christine Finck, MD, FACS
Division Head
Brendan Campbell, MD, MPH, FACS
Meghna Misra, MD
Christine Rader, MD
Richard Weiss, MD, FACS
Jessica Cooper, APRN
Jeanette Rybski, APRN
Nicole Terenzoni, APRN
39
Pediatric & Adolescent Gynecology
The members of the Division of Gynecology at Connecticut
Children’s Medical Center continue to provide state-of-theart pediatric and adolescent gynecology consultative services in office, operating room, emergency room, and inpatient settings.
The clinical services provided include specialty care in all areas of medical and surgical gynecologic care. These include
reproductive health issues, vulvar and vaginal infections in
children and adolescents, management of abnormal uterine
bleeding and pelvic pain, adolescent endometriosis, congenital abnormalities of the reproductive tract, ovarian cysts and
masses, and adolescent hormonal and contraceptive issues.
Our team of gynecologists provides 24/7 coverage of the
Connecticut Children’s Medical Center’s Emergency Room,
operating room, and in-patient floors.
Our surgical services have expanded in 2014 to include daVinci robotically assisted minimally-invasive gynecologic procedures at Connecticut Children’s for selected patients. Dr.
Frederick Rau performed a robotically-assisted laparoscopic
excision of a congenital uterine anomaly with preservation of
future fertility.
Office evaluations of pediatric and adolescent patients are
done at the Gynecology and Obstetrics Division of Physicians
of Women’s Health by Dr. Frederick Rau, Division Director,
and Drs. Emily Rosenbush, Kerrie Henry, Catherine Graziani,
Kelley Sturrock, Erin Pickett, and Elizabeth Purcell at locations
in Hartford, Farmington, Glastonbury and Rocky Hill. Our extensive range of pediatric and adolescent-friendly gynecologists has improved the ability of community physicians to refer
families for age-appropriate gynecologic care.
Our physicians are members of the North American Society
for Pediatric and Adolescent Gynecology, an international organization dedicated to the gynecologic care of children and
teenagers.
Our physicians collaborate at Connecticut Children’s Medical
Center with the University of Connecticut School of Medicine
Obstetrics/Gynecology and Pediatrics residents and medical
students for in-patient, emergency room and operating room
patient care.
Our physicians emphasize a supportive and minimally intrusive strategy while seeing children, adolescents and families.
For 2015-2016, the division will maintain and improve our
patient’s access to superior specialty care in pediatric and
adolescent gynecology to promote reproductive health and
wellness for our community’s children and teenagers.
STAFF
Frederick J. Rau, MD
Division Director
Catherine Graziani, DO
Kerrie Henry, MD
Erin Pickett, MD
Elizabeth Purcell, MD
Ellen Robinson, MD
Emily Rosenbush, MD
Kelley Sturrock, MD
40
Hematology-Oncology
We improve the lives of children with cancer and blood disorders by delivering high quality family-centered academic
health care. We continuously improve what we do through
discovery and partnerships. We have three broad areas of
focus: Quality & Safety, Service & Access, and Research &
Teaching.
This year, the Division of Hematology/Oncology has continued to excel in our ability to provide the highest quality of care
with our focus on standardized approaches when appropriate;
we encourage the development of specific areas of expertise
among our faculty, and we are supported by a talented group
of advanced practitioners and nurses as a key component
of our service model. This past year, Dr. Kerry Moss was appointed as the Director of the Palliative Care program. She
has furthered our ability to care for patients and families in
need within Hematology/Oncology and throughout Connecticut Children’s Medical Center. Dr. Michael Isakoff initiated a
national clinical trial for patients with relapsed/refractory Osteosarcoma. We continued the alignment of our advanced
practitioner staff to provide continuous, streamlined, and patient-centered care in both inpatient and outpatient facilities.
In the upcoming year, our biggest initiative will align the organization’s focus on effective and safe care, as we develop a
care team model which emphasizes continuous improvement
initiatives setting the national standards for patient safety and
care delivery in pediatric hematology-oncology.
We are humbled by our high commendations from patients
and families, a testament to our continued striving for a family-centered approach to care delivery. We are supported by
our two active family advisory boards for Sickle Cell Disease
and Cancer Care. We provide comprehensive care using a
team approach to treat children and young adults with cancer, including recurrent and refractory cancer, hemostasis and
thrombotic problems, red cell disorders, and other hematological diseases. Our comprehensive Advanced Cancer Care
Program is continuing to expand with increased regional, national and international referrals to our Center for Advanced
Therapeutics Program for the Phase 1 and 2 therapies.
Our research efforts continue to expand. Our Children’s Oncology Group participation, under the leadership of Michael
Isakoff, MD, is one of the highest in the country. Division CoDirector Nehal Parikh, MD, has developed the Center for Advanced Therapeutics into a program of national significance
through local and national collaborations. We are members of
two national consortiums (Sunshine Project and Neuroblastoma Medulloblastoma Translational Research Consortium)
bringing novel Phase 1 and Phase 2 treatments to children
with relapsed and refractory cancers. Dr. Parikh was a recipient of St. Baldrick’s Infrastructure grant to further build this
program. We have continued to expand our partnership with
Jackson Laboratories to develop a personalized approach
to cancer therapeutics. Under the leadership of Dr. Michael
Isakoff, the Adolescent and Young Adult Program, supported
by the Nascembini Foundation and the Reid R. Sacco Adolescent and Young Adult Cancer Alliance, has collaborated
and expanded our consultation for young adults at Hartford
Hospital, St. Francis Medical Center, and UConn Health Center. Additionally, Dr. Isakoff has received support from Lea’s
Foundation for Leukemia Research to support the opening
of clinical trials focused on the area of leukemia and lymphoma. Dr. Andrea Orsey is leading the way in implementing an exercise program to improve the quality of life for
children undergoing cancer treatments. This past year, she
was awarded CHIP UConn/UCHC seed funding for a pilot
yoga intervention project to improve pediatric cancer patient’s
quality of life. Dr. Orsey also has been appointed as the cochair of the subcommittee in Global Health initiative within
the America Society of Pediatric Hematology/Oncology. Dr.
Donna Boruchov’s expertise and state grant funding for our
sickle cell patients has guided regional standards for exceptional care. Dr. Boruchov also has received grant funding for
participation in nationwide genotyping and repository of our
hemophilia patients. Our newest member of the division, Natalie Bezler, MD, was awarded a Hyundai Young Investigator
Award for her research in health literacy.
PUBLICATIONS
Andemariam B, Owarish-Gross J, Grady J, Boruchov D,
Thrall RS, Hagstrom JN. Identification of risk factors for an
unsuccessful transition from pediatric to adult sickle cell disease care. Pediatr Blood Cancer. 2014 Apr;61(4):697-701.
Armstrong AE, Gillan E, DiMario FJ Jr. SMART syndrome
(stroke-like migraine attacks after radiation therapy) in adult and
pediatric patients. J Child Neurol. 2014 Mar; 29(3):336-41.
Robison NJ, Campigotto F, Chi SN, Manley PE, Turner CD,
Zimmerman MA, Chordas CA, Werger AM, Allen JC, Goldman
41
Hematology-Oncology
S, Rubin JB, Isakoff MS, et al. A phase II trial of a multiagent oral antiangiogenic (metronomic) regimen in children
with recurrent or progressive cancer. Pediatr Blood Cancer.
2014 Apr;61(4):636-42.
Cortezzo DE, Sanders MR, Brownell EA, Moss K. End-of-
life care in the neonatal intensive care unit: experiences of
staff and parents. Am J Perinatol. 2014 Dec 17.
Fuentes S, Parikh N. Neuroblastoma. In: Stefan and Rodriguez-Galindo, editors. Pediatric hematology-oncology in
countries with limited resources. 1st ed. New York: Springer;
2014. p. 337-53.
STAFF
Natalie Bezler, MD
Taryn Hamre, APRN
Michael Isakoff, MD
Division Co-director
Donna Boruchov, MD
Kerri McGeary, PA-C
Kerry Moss, MD
Kathleen O’Leary, APRN
Eileen Gillan, MD
Hilarie Orton, PA-C
Arnold Altman, MD
Professor Emeritus
Megan Coco, APRN
Emily Peluso, APRN
Christine Eaccarino, APRN
Kimberly Ramjattan, PNP-BC
Andrea Orsey, MD
Karina Engelke, APRN
Katherine Steven, APRN
Nehal Parikh, MD
Division Co-director
Sarah Wentworth, APRN
42
Hospital Medicine
The Division of Hospital Medicine is committed to providing exceptional, value-based care to hospitalized children
and their families. We value educational excellence, strong
collaborations, and continued contributions to the advancement of our field.
Pediatric Hospital Medicine is the fastest growing specialty
within Pediatrics and our division has continued to grow at
a rapid pace. We provide general inpatient pediatric care at
Connecticut Children’s Medical Center in Hartford, as well as
at our 12-bed satellite unit at St. Mary’s Hospital in Waterbury,
CT. Our patient volume has grown over 50 percent in the past
five years (2009 to 2013). We continue to partner with primary care groups to assume the care of their inpatients – 96
percent of general pediatric inpatients are now cared for by
the hospitalist service. This year we were thrilled to welcome
back David Marcello, MD. He returned as a full-time member of the division after a period of time spent developing the
Connecticut Children’s Sedation Program. We also continue
to oversee a highly proficient group of APRNs and PAs who
provide outstanding care and have also led in the development of many of our new clinical pathways.
Clinical accomplishments during the past year were numerous.
We strengthened our new Co-management Program in which
we provide medical expertise in the care of complex surgical
patients. This role has improved communication and family satisfaction, and led to a 20-fold increase in our consult volume in
two years. We continue to track discrete quality metrics in the
division. Our physicians were able to call the primary care provider at discharge over 95 percent of the time and completed
a full asthma home treatment plan over 93 percent of the time,
putting us in the top quartile nationally. Our new system for early
recognition of high patient acuity has expanded, with 300 PICU-level team activations in 2014. We have further standardized best practice via multiple new Clinical Pathways, including
both medical and, most recently, surgical diagnoses. For our
asthma patients, we have been able to demonstrate reduced
length of stay and costs, with no increase in readmits, and with
improvements in preventive care. This is perhaps the best example of how as hospitalists we can improve value, which will
be increasingly important as health care systems evolve.
Education of the next generation of pediatric providers remains an important part of our mission. Our faculty members
continue to excel in this area. Dr. Kathy Kalkbrenner earned
the prestigious overall Faculty Teaching Award, given to the
faculty member who has had the greatest positive impact on
the learning of pediatric residents. Dr. David Marcello was also
honored with a teaching award for his excellent skills in education.
Members of the division continue to share their work on a
national level. Division Head Dr. Anand Sekaran presented a
talk on hospitalist co-management of neurosurgery patients
at the Pediatric Academic Society. Dr. Sekaran was joined by
Drs. Waynik and Skurkis as they led a workshop to teach faculty from around the country how to create and implement
Clinical Pathways in their own institutions. Our APRN group
was nationally visible as well, as Grace Hong presented her
work on a community-acquired pneumonia pathway at the
National Pediatric Nurse Practitioner Annual Meeting. Physician Assistant Kara Denz presented our new Urinary Tract
Infection pathway at the national PA meeting. We take great
pride in sharing our work and in helping others to improve
along with us.
As hospitalists, we continue to evolve in how we provide value,
educate trainees, and improve care. Our goal is to not only
measure our performance against national standards but to
be at the top of those increasingly recognized benchmarks.
Yet as we continue to grow, we strive to maintain our greatest
core value of putting patients and families first in all we do.
PUBLICATIONS
Waynik I, (contributing member of the Pediatric Research in
Inpatient Settings Network collaborators). Comparative effectiveness of intravenous vs. oral antibiotics for post-discharge
treatment of acute osteomyelitis in children. JAMA Pediatr. 2014 Dec 15. doi:10.1001/jamapediatrics.2014.2822.
[Epub ahead of print]
FACULTY
Anand Sekaran, MD
Division Head
Richard Johnson, MD
Kathy Kalkbrenner, MD
David Marcello, MD
43
Hospital Medicine
Marta Mieczkowska, MD
MacDara Tynan, MD
Jill Herring, APRN
Chris McDermott, MD
Ilana Waynik, MD
Grace Hong, APRN
Christine Skurkis, MD
Basia Adams, APRN (Leader)
Samantha Lee, APRN
Catherine Sullivan, MD
Kara Denz, PA-C
44
Human Genetics
The Division of Human Genetics resides jointly in the Department of Genetics and Genome Sciences as well as the
Department of Pediatrics. The mission of the division is to
provide high quality, timely and state-of-the-art genetic consultations, counseling, and treatment for patients from the
prenatal period throughout childhood and into adulthood.
This care over the lifespan is provided by clinical geneticists,
genetic counselors and a part-time metabolic dietician (2.0
FTE clinical geneticists, 2.0 full-time prenatal genetic counselors, 1.8 hereditary cancer genetic counselors, 1.0 “teratogen”
counselor, and 0.4 metabolic dietician) at two campuses. The
clinical/administrative/academic offices this year moved to
the UConn campus at 263 Farmington Ave., Farmington, Connecticut, where children and adults are seen in a general genetics clinic, and where prenatal and hereditary cancer patients
receive genetic counseling. MotherToBabyCT has moved to
195 Farmington Ave., Farmington. At our site for Connecticut
Children’s, children are seen in our outpatient clinic at 11 South
Road, Farmington.
A full-service cytogenetics laboratory run by Dr. Peter Benn
at John Dempsey Hospital provides testing for internal and
external patients.
Patients with metabolic disease identified through the DPH
Newborn screening program, as well as children diagnosed at
a later age, are seen in our UConn office in conjunction with
our metabolic dietician.
There have been no major changes in the scope of patients
seen. However, increased use of non-invasive prenatal genetic testing continues to increase the number of patients being
seen by the prenatal service, and frequently updated test offerings for patients with hereditary cancers has increased the
patient numbers being seen and evaluated by the hereditary
cancer counseling program. MotherToBabyCT, our teratogen
counseling program, is expanding its coverage throughout
the state.
Collaborations with Connecticut Children’s Medical Center,
Department of Public Health Newborn Screening Program,
UConn’s Maternal–Fetal-Medicine program, and Neag Cancer Center are robust and active. A $225,000 Department of
Public Health annual contract helps to support the newborn
screening/metabolic and MotherToBabyCT programs.
The division’s educational mission begins in the first year of
medical school and goes through postgraduate fellowship.
We have an active medical genetics fellowship, including a
two-year post-residency fellowship and one of only 16 combined pediatric-medical genetics residency programs nationally. There are also student, resident, fellow, and genetic counseling learners who spend a month’s rotation in genetics. In
addition, one pediatric resident arranged a weekly longitudinal
rotation.
The year 2014 was a busy one for Dr. Benn who delivered invited presentations to international audiences at conferences
in Portugal, Italy, India, Australia and New York. Benn serves as
a reviewer for 10 publications including The American Journal of Medical Genetics, The American Journal of Obstetrics and Gynecology, Genetics in Medicine, and Prenatal
Diagnosis. He is a member of the board of the International
Society for Prenatal Diagnosis.
The division’s genetic counselors received the following recognition:
Brittany Gancarz, MS, CGC, received UConn’s Touchstone Innovation Award for her work in the area of perinatal palliative
care.
Sharon Lavigne, MS, was an invited speaker at the annual
Teratology Course at Harvard’s Mass General Hospital. The
division’s teratogen counseling program, MotherToBabyCT,
received a grant entitled “Reproductive and Environmental
Health Network” through HRSA.
Robin Schwartz, MS, CGC, is co-chair of the Education and
Workforce Development, Genetic Advisory Committee at the
CT Department of Public Health.
NEW/ONGOING COLLABORATIONS
Sally Rosengren, MD, is a co-investigator for an Affinity Research Collaborative project, whose goals are to look at specific clinical, historical, genetic, and functional aspects of autism. This project was funded in July 2013 by the Institute for
Systems Genomics for five years. Other agencies participating in this ARC include Connecticut Children’s Medical Center and Jackson Laboratories.
Robin Schwartz and Jennifer Stroop, CGCs, are both col-
45
Human Genetics
laborating investigators in the CICATS project, “Determining
clinical significance of mismatch repair variants,” with PI Chris
Heinen, PhD.
Drs. Rosengren and Joseph Tucker are active members of
the GUPPE program, and along with the Urology, Psychiatry, Psychology and Endocrinology divisions at Connecticut
Children’s, they provide multidisciplinary care for children with
disorders of sexual development.
PUBLICATIONS
BOOK CHAPTER
Benn P. Debate: Screening in recurrent pregnancy loss: nonspecific testing is insufficient. In: Carp H, editor. Recurrent
pregnancy loss: causes, controversies and treatment. 2nd ed.
CRC Press. 2014.
STAFF
Sally Rosengren, MD
Division Head
Benn P, Cuckle H. Theoretical performance of non-invasive
prenatal testing for chromosome imbalances using counting
of cell-free DNA fragments in maternal plasma. Prenat Diagn.
2014;34:778-83.
Peter Benn, PhD
Chapman AR, Benn PA. Noninvasive prenatal testing for
early sex identification: a few benefits and many concerns.
Perspect Biol Med. 2014;56:530-47.
Sharon Lavigne, MS
Dar P, Curnow KJ, Gross SJ, Hall MP, Stosic M, Demko Z, Zimmermann B, Hill M, Sigurjonsson S, Ryan A, Banjevic M, Kolacki PL, Koch SW, Strom CM, Rabinowitz M, Benn P. Clinical
experience and follow-up with large scale single-nucleotide
polymorphism-based noninvasive prenatal aneuploidy testing.
Am J Obstet Gynecol. 2014;211:527.e1-527.e17.
Joseph Tucker, MD
Alicia Craffey, MS
Ginger Nichols, MS
Robin Schwartz, MS
Brittany Gancarz, MS
Jennifer Stroop, MS
FACULTY EMERITUS
Robert Greenstein, MD
46
Infectious Diseases & Immunology
In 2014, the Division of Infectious Diseases and Immunology had their busiest year yet, with consistent growth in
inpatient and outpatient consultations, while leading the
hospital response to the threat of Ebola in West Africa.
The division continued this year in its mission to provide the best
possible care to children in Connecticut suffering from infectious
diseases and immune deficiencies. In addition to providing care
at Connecticut Children’s Medical Center, our members provided
educational outreach across the state, and successfully advocated for an expansion in the state vaccination program to properly
serve children with immune deficiencies.
The unprecedented outbreak of Ebola in West Africa, combined with the realities of rapid, global travel, led Connecticut Children’s to enhance its existing disaster preparedness
planning to focus on safely detecting, isolating, and treating
children with possible Ebola infection. Led by Dr. Andrea Benin, with significant contributions from Dr. Nicholas Bennett
and the other members of the division, the Ebola Taskforce
developed clinical pathways, trained over 100 hospital staff
members, and remodeled four hospital rooms in the event of
having to care for children exposed to or infected with any serious communicable infection. In five short but intense weeks,
we significantly upgraded our ability to deal with health care
disasters, including infectious diseases, but with skills and
equipment that could be transferred to many other scenarios.
Clinical growth was assisted by the addition of Dr. Thomas
Murray MD, PhD, also of Quinnipiac University School of
Medicine, who brings to the division his experience and training in clinical microbiology, as well as pediatric infectious diseases. Dr. Murray is involved with research collaborations with
Pediatric Pulmonology at Connecticut Children’s, and is the
director of the Capstone longitudinal research experience at
Quinnipiac. The division of Infectious Diseases and Immunology was the first of two clinical divisions to mentor students
as part of that experience.
We continue to provide comprehensive care, supported by
the Ryan White program, for HIV-infected youth and HIV-exposed children and neonates. This year saw several referrals
from new overseas adoptions, where we were ideally placed
to provide comprehensive care including diagnosis and treatment of parasitic diseases, advice on vaccine requirements,
and to adapt treatment regimens to the United States’ equivalents.
The Antimicrobial Stewardship Program, led by Dr. Bennett
and Jennifer Girotto, PharmD, expanded its remit by becoming one of only two programs in the United States to offer a
one-year pharmacy residency in pediatric infectious diseases.
This not only enhanced our ability to provide effective stewardship guidance to the clinicians at Connecticut Children’s,
and further our research efforts, but will provide a lasting contribution to the national effort to improve antibiotic use in pediatric medicine.
The division continues to publish cutting-edge research, funded by NIH R01 and R03 grants held by Dr. Salazar, as well as
clinical reports and reviews.
ACTIVE GRANTS
R0-1 AI090166 NIAID – Phagosomal signals shape inflammatory responses to Borrelia burgdorferi. Direct amount per
year $315,000. (Active: 07/15/2011- 6/30/2016) PI: Dr.
Juan Salazar.
R03 TW00972 – Mechanisms of immune evasion in human
syphilis. (Active: 3/1/2013-11/30/2015) Co-PI: Dr. Juan
Salazar.
Colciencias Grant (Colombian National Institute of Sciences)
– Natural killer cells in syphilis infection. (Active 2/1/201312/31/2014) Co-PI: Dr. Juan Salazar.
AI-29735 NIH RpoS regulation of Borrelia burgdorferi genes
in vivo. (Active 2/1/2013-1/31/2018) Co-Invest: Dr. Caimano.
PUBLICATIONS
Bennett N. Pneumocystis jirovecii pneumonia prophylaxis for
HIV-exposed neonates. Res Rep Neonatol. 2014;Apr;4:71–4.
Brandt KS, Patton TG, Allard AS, Caimano MJ, Radolf JD,
Gilmore RD. Evaluation of the Borrelia burgdorferi BBA64
protein as a protective immunogen in mice. Clin Vaccine Immunol. 2014;21(4):526-33. PMID: 24501342.
Caimano MJ, Sivasankaran SK, Allard A, Hurley D, Hokamp
K, Grassmann AA, Hinton JC, Nally JE. A model system for
studying the transcriptional and physiological changes associated with mammalian host-adaption by Leptospira interrogans
serovar Copenhageni. PLoS Pathog. 2014;10(3):e1004004.
PMID 24626166.
47
Infectious Diseases & Immunology
Cervantes JL, Hawley KL, Benjamin SJ, Weinerman B, Luu
SM, Salazar JC. Phagosomal TLR signaling upon Borrelia
burgdorferi infection. Front Cell Infect Microbiol. 2014 May
20;4:55.
Feder HM Jr. Lyme disease. N Engl J Med. 2014 Aug
14;371(7):683-4.
Fornari A, Murray TS, Menzin AW, Woo VA, Clifton M,
Lombardi M, Shelov S. Mentoring program design and implementation in new medical schools. Med Educ Online.
2014;19:24570. doi:10.3402/meo.v19.24570.
Held M, Burke G, Zalneraitis E. Pediatric residency program
hand-over: before and after the ACGME requirement. Acad
Pediatr. 2014 Nov/Dec;14(6):610-15.
Kassam Z, Murray TS. Navigating the pediatric microbiome:
emerging evidence and clinical implications. Curr Pediatr Rep.
2014. doi:10.1007/s40124-014-0040-1.
Kulkarni M, Tichy A, Pyka J, Murray T, Hodsdon M, Peaper
D. 2014. Use of imipenem to detect KPC, NDM, OXA, IMP,
and VIM carbapenemase activity from gram negative rods in
1 hour using LC-MS/MS. J Clin Microbiol. 2014;52:2500-5.
Libardo MD, Cervantes JL, Salazar JC, Angeles-Boza AM.
Improved bioactivity of antimicrobial peptides by addition of
amino-terminal copper and nickel (ATCUN) binding motifs.
ChemMedChem. 2014 Aug;9(8):1892-901.
Miller KA, Motaleb MA, Liu J, Caimano MJ, Miller MR,
Charon NW. Initial characterization of the Flg hook high molecular weight complex of Borrelia burgdorferi. PLoS One.
2014;9(5):e98338. PMID 24859001.
Rogers S, Cohen-Abbo A. Mononucleosis. Rosen & Barkin’s 5-minute emergency medicine consult.
Salazar JC, Cahn P, Della Negra M, De Aquino MZ, Robinson PA, Jelaska A, Mikl J. Efficacy and safety of tipranavir
coadministered with ritonavir in HIV-1-infected children and
adolescents: 5 years of experience. Pediatr Infect Dis J. 2014
Apr;33(4):396-400.
Somily AM, Habib HA, Absar MM, Arshad MZ, Manneh K, Al
Subaie SS, Al Hedaithy MA, Sayyed SB, Shakoor Z, Murray
TS. ESBL Producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia. J Infect
Dev Ctries. 2014;8:1129-36. doi:10.3855/jidc.4292. PMID:
25212077.
Somily AM, Al-Subiae SS, BinSaeed AA, Torchyan A, Alzamil
F, Al-Aska AI, Al-Khattaf FS, Khalifa LA, Al-Thawadi SI, Alaidan W, Al-Ahdal MN, Al-Qahtani AA, Murray TS. Extended
spectrum beta-lactamase producing Klebsiella pneumoniae outbreak in the neonatal intensive care unit of a teaching hospital, does vancomycin have role? Am J Infect Cont.
2014;42:277-82.
Sweet L, Held M. Paeditricians in training: a global child
health elective curriculum. MedEdPublish. 2014;3:35.
Valdez TA, Marvis K, Bennett NJ, Lerer T, Nolder AR, Buchinsky FJ. Current trends in perioperative antibiotic use: a survey
of otolaryngologists. Otolaryngol Head Neck Surg. 2014 Oct
10.
Xu H, Sobue T, Thompson A, Xie Z, Poon K, Ricker A, Cervantes J, Diaz PI, Dongari-Bagtzoglou A. Streptococcal coinfection augments Candida pathogenicity by amplifying
the mucosal inflammatory response. Cell Microbiol. 2014
Feb;16(2):214-31.
STAFF
Juan C. Salazar, MD, MPH
Division Head
Nicholas Bennett, MBBChir, PhD
Andrea Benin, MD
Alberto Cohen-Abbo, MD
Henry M. Feder, Jr., MD
Melissa Held, MD
Hillary Hernandez-Trujillo, MD
Thomas Murray, MD, PhD
Gavin Schwarz, MD
Jennifer Girotto, PharmD
48
Neonatology
The Division of Neonatology directs one of the largest and
most diverse clinical services in New England and is the
perinatal regional center for northern Connecticut.
The Division of Neonatal-Perinatal Medicine includes faculty at
five major sites: Connecticut Children’s Medical Center (Hartford), Connecticut Children’s Medical Center at the University of
Connecticut Health Center (UCHC)/John Dempsey Hospital
(JDH), St. Francis Hospital and Medical Center (SFHMC), the
Hospital of Central Connecticut (THOCC), and Eastern Connecticut Health Network (ECHN). Faculty members work collaboratively across sites to achieve goals in quality of care, education,
training, and research. In support of this multi-site program, Dr.
David Sink was appointed site director at the Connecticut Children’s NICU at UCHC.
As the regional perinatal center, the division provides clinical
leadership and outreach education for hospitals throughout
Connecticut. The neonatal transport program was incorporated into Connecticut Children’s Critical Care Transport and
completed its first full year of operations transporting over
300 newborns throughout the region and state. Neonatal
transports are performed by NICU-specific staff providing
service to referring hospitals throughout Connecticut. The
neonatal follow-up program provides transitional short-term
medical follow-up and neurodevelopmental follow-up for high
risk infants from all NICUs in the region.
The CT Perinatal Collaborative was launched this year under
the leadership of Dr. Marilyn Sanders, in collaboration with the
Yale Division of Neonatology and the CT March of Dimes. The
collaborative works with all birthing hospitals in the state to
improve care for all newborns. The focus for its first year is on
improving breastfeeding initiation rates and reducing necrotizing enterocolitis.
The CT Human Milk Research Center was established under
the leadership of Elizabeth Brownell, PhD, and has several
active research projects and publications. The division held
its second bi-annual Neonatal–Perinatal Research Day. This
year’s program’s focus was on necrotizing enterocolitis featuring presentations by local and invited investigators as well
as 25 research posters encompassing a variety of topics in
neonatal-perinatal medicine.
Dr. Kathleen Marinelli received the United States Breastfeeding Committee Distinguished Service Award and the Academy of Breastfeeding Medicine Board Service Award. She
was also named Chair of the Baby-Friendly US NICU Initiative and elected to the Board of the International Lactation
Consultant Association as Director of Professional Development.
PUBLICATIONS
Hagadorn JI, Salikooti S, Pappagallo M, AriasCamison J, Alba J, Herson V, et al. Postpartum triage, services provided, and length of stay for infants born at 35 weeks
gestation. Am J Perinatol. 2014 Dec 23. [Epub ahead of print]
Brownell EA, Hagadorn JI, Lussier MM, Lerer TJ, Herson
VC, Howard CR, et al. Optimal periods of exclusive breastfeeding associated with any breastfeeding duration through
one year. J Pediatr. 2015 Mar;166(3):566-570.e1. doi:
10.1016/j.jpeds.2014.11.015. Epub 2014 Dec 16.
Hagadorn JI, Brownell EA, Lussier MM, Parker MG,
Herson VC. Variability of criteria for pasteurized donor human milk use: a survey of U.S. neonatal ICU medical directors. JPEN J Parenter Enteral Nutr. 2014 Sep 29. doi:
10.1177/0148607114550832. [Epub ahead of print]
Campbell BT, Herbst KW, Briden KE, Neff S, Ruscher
KA, Hagadorn JI. Inhaled nitric oxide use in neonates
with congenital diaphragmatic hernia. Pediatrics. 2014
Aug;134(2):e420-6. doi: 10.1542/peds.2013-2644. Epub
2014 Jul 14.
Brownell EA, Lussier MM, Esposito P, Briere CE, Herson
VC, Hagadorn JI, et al. Patterns and predictors of donor human milk non-consent in the neonatal ICU. Breastfeed Med.
2014 Oct;9(8):393-7. doi: 10.1089/bfm.2014.0044. Epub
2014 Jul 9.
Marinelli KA, Lussier MM, Brownell E, Herson VC,
Hagadorn JI. The effect of a donor milk policy on the diet
of very low birth weight infants. J Hum Lact. 2014 Apr
18;30(3):310-316. [Epub ahead of print]
Brownell EA, Lussier MM, Hagadorn JI, Herson VC,
Marinelli KA. Authors’ response to “a letter to the editor
regarding ‘donor human milk bank data collection in North
America: an assessment of current status and future needs’
from the human milk banking association of North America.”
J Hum Lact. 2014 May;30(2):243.
49
Neonatology
Ruiz TL, Trzaski JM, Sink DW, Hagadorn JI. Transcribed
oxygen saturation vs. oximeter recordings in very low birth
weight infants. J Perinatol. 2014 Feb;34(2):130-5.
Brownell EA, Lussier MM, Hagadorn JI, McGrath JM,
Marinelli KA, Herson VC. Independent predictors of human milk receipt at neonatal intensive care unit discharge. Am
J Perinatol. 2014 Nov;31(10):891-8.
Brownell EA, Lussier MM, Herson VC, Hagadorn JI,
Marinelli KA. Donor human milk bank data collection in
North America: an assessment of current status and future
needs. J Hum Lact. 2014 Feb;30(1):47-53.
Lang SM, Giuliano JS Jr, Carroll CL, Rosenkrantz TS,
Eisenfeld L. Neonatal/infant validation study of the CAS
model 740 noninvasive blood pressure monitor with the
Orion/MaxIQ NIBP module. Blood Press Monit. 2014
Jun;19(3):180-2.
Meigh L, Hussain N, Mulkey DK, Dale N. Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2 Elife. 2014 Nov 25;3:e04249.
Shamshirsaz AA, Ravangard SF, Ozhand A, Haeri S, Shamshirsaz AA, Hussain N, et al. Short-term neonatal outcomes
in diamniotic twin pregnancies delivered after 32 weeks and
indications of late preterm deliveries. Am J Perinatol. 2014
May;31(5):365-72.
Selvaraju V, Parinandi NL, Adluri RS, Goldman JW, Hussain
N, Sanchez JA, et al. Molecular mechanisms of action and
therapeutic uses of pharmacological inhibitors of HIF-prolyl
4-hydroxylases for treatment of ischemic diseases. Antioxid
Redox Signal. 2014 Jun 1;20(16):2631-65.
Hussain N, Shamshirsaz AA, Haeri S, Ravangard SF, SangiHaghpeykar H, Gandhi M, et al. Perinatal outcomes based
on the institute of medicine guidelines for weight gain in
twin pregnancies. J Matern Fetal Neonatal Med. 2014
Apr;27(6):552-6.
Wight N, Marinelli KA. ABM clinical protocol #1: guidelines for blood glucose monitoring and treatment of hypoglycemia in term and late-preterm neonates, revised 2014.
Academy of Breastfeeding Medicine. Breastfeed Med. 2014
May;9(4):173-9.
Evans A, Marinelli KA, Taylor JS. ABM clinical protocol #2:
Guidelines for hospital discharge of the breastfeeding term
newborn and mother: “The going home protocol,” revised
2014. Academy of Breastfeeding Medicine. Breastfeed Med.
2014 Jan-Feb;9(1):3-8.
Cortezzo DE, Sanders MR, Brownell EA, Moss K. Endof-life care in the neonatal intensive care unit: experiences of
staff and parents. Am J Perinatol. 2014 Dec 17.
Brownell EA, Lussier MM, Dozier AM, Howard CR, Fisher
SG, Duckett JW, et al. The discordance between planned use
and actual receipt of immediate postpartum depot medroxyprogesterone among low-income women. Breastfeed Med.
2014 Jul-Aug;9(6):290-3.
Dozier AM, Nelson A, Brownell EA, Howard CR, Lawrence
RA. Patterns of postpartum depot medroxyprogesterone administration among low-income mothers. J Womens Health
(Larchmt). 2014 Mar;23(3):224-30.
Dozier AM, Brownell E, Guido J, Yang H, Howard CA, Doniger A, et al. Adapting the pregnancy risk assessment monitoring survey to enhance locally available data: methods. Matern
Child Health J. 2014 Jul;18(5):1196-204.
Smith AL, Hill CA, Alexander M, Szalkowski CE, Chrobak JJ,
Rosenkrantz TS, et al. Spatial working memory deficits in
male rats following neonatal hypoxic ischemic brain injury
can be attenuated by task modifications. Brain Sci. 2014 Apr
2;4(2):240-72.
Rhein LM, Dobson NR, Darnall RA, Corwin MJ, Heeren TC,
Poets CF, et al, Caffeine Pilot Study Group (Rosenkrantz
T). Effects of caffeine on intermittent hypoxia in infants born
prematurely: a randomized clinical trial. JAMA Pediatr. 2014
Mar;168(3):250-7.
Smith AL, Alexander M, Rosenkrantz TS, Sadek ML, Fitch
RH. Sex differences in behavioral outcome following neonatal
hypoxia ischemia: insights from a clinical meta-analysis and
a rodent model of induced hypoxic ischemic brain injury. Exp
Neurol. 2014 Apr;254:54-67.
Alexander M, Garbus H, Smith AL, Rosenkrantz TS, Fitch
RH. Behavioral and histological outcomes following neonatal
HI injury in a preterm (P3) and term (P7) rodent model. Behav
Brain Res. 2014 Feb 1;259:85-96.
Mourani PM, Kinsella JP, Clermont G, Kong L, Perkins AM,
50
Neonatology
Weissfeld L, et al, Prolonged Outcomes After Nitric Oxide
(PrONOx) Investigators (Pappagallo M). Intensive care unit
readmission during childhood after preterm birth with respiratory failure. J Pediatr. 2014 Apr;164(4):749-755.
Alur P, Bollampalli V, Bell T, Hussain N, Liss J. Correlation of
caffeine concentrations with short term outcomes in premature infants of ≤ 29 weeks gestation. J Perinatol. 2014 Dec
18. doi: 10.1038/jp.2014.226. [Epub ahead of print]
STAFF
Victor C. Herson, MD
Division Head
Amir LH, Academy of Breastfeeding Medicine Protocol Committee (Marinelli K, Bunik M, Noble L, Brent N, Grawey
AE, Holmes AV, Lawrence RA, Seo T). ABM Clinical Protocol #14: Mastitis, revised March 2014. Breastfeed Med.
2014;9(5):239-243.
BOOK CHAPTER
Hussain N. Epigenetics in childhood health and disease. In:
Maulik N, Karagiannis T, editors. Molecular mechanisms and
physiology of disease: implications for epigenetics and health.
New York: Springer; 2014. p. 1-62.
John R. Raye, MD
(retired, honorary staff)
Ted S. Rosenkrantz, MD
Jose Arias-Camison, MD
Saritha Salikooti, MD
Tina Rita Bafumi, MD (Middlesex)
Marilyn Sanders, MD
Fadel Balawi, MD (SFHMC)
Shikha Sarkar, MD
Hema DeSilva, MD
Professor Emeritus
David Walker Sink, MD
Leonard I. Eisenfeld, MD
James Hagadorn, MD
Jennifer Trzaski, MD
Aniruddha Vidwans, MD
Leslie I. Wolkoff, MD
Bernadette A. Hillman, MD
(THOCC)
Rebecca Beebe, PhD
Naveed Hussain, MBBS, DCH
Jacqueline McGrath, PhD
Carla Jacobson-Kiel, MD
Sabrina Colangelo, PA-C
Shabnam Lainwala, MD
Shivani Desai, PA-C
Kathleen Marinelli, MD
James Gerace, PA
Adam Matson, MD
Kristen Moore, PA
Arpana Mohnani, MD
(THOCC)
Jessica Simao, PA
Indira Panthagani, MD
Jessica Cauchon, APRN
Mariann Pappagallo, MD
Lucia Onofrio, PA-C
Angela Boisseau, APRN
Mary Brennan-Centrella, APRN
Stephanie Capps, APRN
Karen Cleveland, APRN
Jill Herr, APRN
Lindsay Leighton, APRN
Michelle Letendre, APRN
Jennifer Long, APRN
Stephanie McGuire, APRN
Suanne Menick, APRN
Karen O’Brien, APRN
Terry Poppiti, APRN
Christine Raymond, APRN
Megan Richardson, APRN
Stacey Rubin, APRN
Patricia Trehey, APRN
Lindsay Tucker, APRN
Alyssa Weiss, APRN
Erin Vlahakis, APRN
Mary Young, APRN
Allyson Dacruz, PA-C
51
Neonatology
Corey Champeau, PA-C
Karen Cleaveland, APRN
Wendy Petow, APRN
Brian Landry, PA-C
Anna Camacho, APRN
Karen Pietruszkiewicz, APRN
Kristen Moore, PA-C
Nicole Duguay, APRN
Laura Pittari, APRN
Stacy Voegeli, PA-C
Maria Haar, APRN
Christine Raymond, APRN
Margaret Wilber, PA-C
Nick Markey, APRN
Babette Sternat, APRN
Kim Oski, APRN
Claudia Wittenzellnew, APRN
52
Nephrology
This was an exciting year as the division has seen significant changes with the successful recruitment of a third fulltime nephrologist, Dr. Samriti Dogra, as well as a part-time
renal dietitian, Kyle Lamprecht, MS, RD, CD-N. These additions increased capacity to treat children with renal diseases from across the state. Volume was up significantly,
specifically renal transplantation, which saw the successful
transplant of five patients in an 18-month span. The leadership of the division has come under structure change as
well. We are excited to report that Dr. Cynthia Silva was
promoted to Division Head. As the Division of Nephrology
continues to grow, the greater goal is to move toward a service line blending Urological and Renal services under the
same structure. To this end, the division rolled out a multidisciplinary clinic aimed at caring for children with complex
urological malformations and chronic renal failure as well as
kidney stone patients.
Two new multidisciplinary clinics were added this past academic year; a chronic renal failure clinic for children with
urological malformation as well as a clinic for kidney/bladder stones. We are the first Nephrology section in the state
to offer such an array of clinics, which involve board-certified
Nephrologists, Urologists, Pediatricians, dietitians, mid-levels
and social workers. Drs. Mason, Silva and McDonald are all
board-certified Pediatric Nephrologists.
Dr. Bruce McDonald re-started providing renal services at our
Shelton location this year, which was a divisional goal in 2013.
The Shelton satellite has increased services to our patients in
Fairfield County and yielded an increased referral base, which
now also includes New Haven County. The division is pushing forward to expand services in other areas, and plans for
Dr. Mason to see patients in our Farmington location are well
underway.
The division increased care for more than 3,000 outpatient
visits as well as increasing in-patient volumes. The visits were
comprised of pre-transplant, post-transplant, inpatient and
outpatient consults as well as acute and chronic dialysis. The
division continues to work closely with the ICU on a regular
basis to provide continuous veno-venous hemodialfiltration
for our sickest patients.
Dr. Silva was invited to participate in the prestigious Mid West
Pediatric Nephrology Consortium (MWPNC), which is a multicenter research collaborative aimed at improving knowledge
and clinical care for children with renal disorders. The division
has multiple IRB-approved research studies active at this
time as well as joint research collaborative with the Division
of Urology.
As we look forward to the upcoming year, we expect roll out
of our Nephrology-Urology service line. We also hope to cohort these patients during their in-patient experience for improved clinical outcomes as well as patient satisfaction. We
also will continue our extensive research portfolio and move
from IRB-approved research to funded studies.
PUBLICATIONS
Koraishy FM, D’Alessandri-Silva C, Mason S, Wu D,
Cantley LG. Hepatocyte growth factor (Hgf) stimulates low
density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling. J Biol
Chem. 2014 May 16;289(20):14341-50.
Mason S, Hader C, Marlier A, Moeckel G, Cantley L.G. Met
activation is required for early cytoprotection after ischemic
kidney injury. J Am Soc Nephrol. 2014 Feb;25(2):329-37.
Riemenschneider M, Makari J, Rochon C, Ferrer F,
D’Alessandri-Silva C. Mass in failed renal allograft. Pediatr
Nephrol. Epub ahead of print: 2014 Sept 4.
Thangada S, Shapiro LH, D’Alessandri-Silva C, Yamase
H, Hla T, Ferrer FA. Treatment with the Immunomodulator
FTY720 (Fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. J Urol. 2014 Mar
25.
BOOK CHAPTER
D’Alessandri-Silva C, Dorsey K. Week 38: enuresis. Yale
Primary Care Pediatrics Curriculum. 6th ed. 2012.
STAFF
Cynthia D’Alessandri-Silva, MD, FAAP
Division Head
Samriti Dogra, MD
Bruce McDonald, MD, FAAP
Sherene
Mason, MD, FAAP, MBA
Molly Band, PA-C
53
Pediatric Neurology
The main mission of the Division of Neurology is to provide
the best available care for children with various neurological
diseases.
in predicting outcomes following seizures in the neonatal period.
We practice according to the latest care guidelines and employ state-of-the-art diagnostic technologies and treatments.
The neurology faculty consists of experts in the fields of epilepsy, electrophysiology, neurocutaneous diseases, neurogenetics and neuromuscular diseases. We collaborate with most
of the other specialties at Connecticut Children’s. Our faculty
members and nurses participate in various national and international conferences. Another important part of our academic
activity is to educate residents and medical students. The division is actively involved in clinical research in autism, epilepsy,
tuberous sclerosis, and neuromuscular diseases.
Dr. Louisa Kalsner (principal investigator) and Dr. Gyula Acsadi (co-investigator) are in a collaborative research program
on autism founded by the joint UConn and Jackson Laboratory ARC Program. Dr. DiMario conducts a multicenter clinical
study on Tuberous Sclerosis. Dr. Acsadi has collaborated with
Sylvia Õunpuu and Dr. Kristan Pierz of the Center of Motion
Analysis to evaluate the gait patterns of CMT patients. Dr. Acsadi participates in the Tone Management program that helps
to treat patients with spasticity. Dr. Jennifer Madan Cohen has
collaborated with Neurosurgery and Hartford Hospital’s adult
epilepsy program to evaluate patients with intractable focal
epilepsy for epilepsy surgery.
MAJOR ACCOMPLISHMENTS
PUBLICATIONS
Dr. Francis DiMario was an invited speaker at the Joint Annual Conference of Indian Epilepsy Association & Indian Epilepsy Society, Kolcata, India, and at the Annual National Conference for Public Responsibility in Medicine and Research
(PRIM&R), Baltimore, MD.
Armstrong AE, Gillan E, DiMario FJ Jr. SMART syndrome
(stroke-like migraine attacks after radiation therapy) in adult
and pediatric patients. J Child Neurol. 2014 Mar;29(3):336-41.
AWARDS
Dr. Richard Young has received the “Meritorious Service
Award” from the U.S. Army.
RECRUITMENTS/DEPARTURES
The Pediatric Neurology Division has recruited two new neurology specialists, Drs. Mark L. Schomer and Christine Matarese, whose expertise includes Epilepsy and Clinical Neurophysiology. Dr. Cristian Ionita accepted a position at Seattle
Children’s Hospital.
EXPANSION
In September 2014, the division’s main office and clinic was
relocated to the new ambulatory building located in Farmington. The Connecticut Children’s hospital clinic was relocated
to 85 Seymour in Hartford.
COLLABORATIONS
Since arriving at Connecticut Children’s, Dr. Schomer has
helped to establish a multi-institutional EEG database, with
collaborators at Boston Children’s Hospital and Columbia
Medical Center, with the goal of finding factors that may help
Held MR, Burke GS, Zalneraitis E. Pediatric residency program handover: before and after the ACGME requirement.
Acad Pediatr. 2014 Nov-Dec;14(6):610-5.
Kissel JT, Elsheikh B, King WM, Freimer M, Scott CB, Kolb SJ,
Reyna SP, Crawford TO, Simard LR, Krosschell KJ, Acsadi
G, Schroth MK, D’Anjou G, LaSalle B, Prior TW, Sorenson S,
Maczulski JA, Swoboda KJ; Project Cure Spinal Muscular Atrophy Investigators Network. SMA valiant trial: a prospective,
double-blind, placebo-controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy. Muscle Nerve.
2014 Feb;49(2):187-92.
BOOK CHAPTERS
DiMario FJ. Tuberous sclerosis complex. In: E-Pocrates.
London, England: BMJ. Revision and update, June 2014.
Acsadi G. In: Greenamyer T, editor. Medlink neurology. Arbor
Publ. updated 2014.
1. A
csadi, G: The Chediak-Higashi syndrome
2. Acsadi, G: Congenital muscular dystrophy: Merosin deficient form
3. A
csadi, G: Duchenne muscular dystrophy
4. A
csadi, G: Becker muscular dystrophy
5. Acsadi, G: Severe autosomal recessive congenital muscular dystrophy
54
Pediatric Neurology
STAFF
Cristian Ionita, MD
Gyula Acsadi, MD
Division Head
Mark Schomer, MD
Francis J. DiMario, Jr, MD
Louisa Kalsner, MD
Jennifer Madan Cohen, MD
Richard Young, MD
Edwin Zalneraitis, MD
Brenda Cowan-Frautschy, APRN
55
Pediatric Neurosurgery
Our Pediatric Neurosurgery program successfully recruited
Dr. Markus Bookland in 2014 following his fellowship training at Emory University in Atlanta.
Dr. Bookland’s clinical practice specializes in the surgical management of brain tumors and minimally invasive procedures.
He maintains an active research laboratory at the University
of Connecticut School of Medicine where he continues investigations of malignant glioma and 3-D neural networking. Our
collaboration with the Jackson Laboratory Avatar program
has been successful at animal modeling of several malignant
and rare brain tumors, providing an extraordinary study of tumor genomics and chemotherapy response. Our spine deformity program has been successful at complex cranial-cervical
junction fusion in very young children using high molecular
weight polyethylene cables to enhance rigid internal fixation.
The spina-bifida program treated a record number of new
children in 2014 born with congenital spine malformations.
Our operating room is fully equipped with an intraoperative CT
scanner, neuro-physiological and EEG monitoring, brain mapping, CO2 laser, and brain-lab navigation image guidance.
Our multi-institutional study of children with craniosynostosis
identified improved neurodevelopmental milestones following
cranioplasty completed when less than 6 months of age. A
cognitive advantage was demonstrated following open expansions compared to minimally invasive procedures followed
by helmet use.
Working closely with the faculty from the Division of Neurology, there has been considerable growth in the epilepsy
surgery program. A record number of temporal lobe resections with intraoperative EEG monitoring were completed.
We maintain collaborations with the neuro-oncology program,
cranio-facial center and our endoscopic sinus surgeons.
PUBLICATIONS
Hashim P, Patel A, Yang J, Travieso R, Terner J, Losee J, Pollack I, Kanev P, Jane J Sr, Jane J Jr, Mayes L, Duncan C,
Bridgett DJ, Persing J. The effects of whole vault cranioplasty
versus strip craniectomy on long-term neuropsychological
outcomes in sagittal craniosynostosis. J Plast Reconstr Surg.
2014;134(3):491-501. Epub 2014 May 6.
Patel A, Yang J, Hashim P, Travieso R, Terner J, Mayes L,
Kanev P, Duncan C, Jane J Jr, Jane J Sr, Pollack I, Losee
J, Bridgett D, Persing J. The impact of the Age of Surgery on
long-term neuropsychological outcomes in sagittal craniosynostosis. J Plast Reconstr Surg. 2014;134(4):608e-617e.
Sarda S, Bookland M, Chu J, Shoja M, Miller M, Reisner S,
Yun P, Chern N. Return to system within 30 days of discharge
following pediatric non-shunt surgery. J Neurosurg Pediatr.
2014 Dec;14(6):654-61.
Chern J, Bookland M, Tejedor-Sojo J, Riley J, Tubbs R, Reisner A. Return to system within 30 days of discharge following pediatric shunt surgery. J Neurosurg Pediatr. 2014
Dec;3(3):525-31.
STAFF
Paul Kanev, MD
Division Chief
Jonathan Martin, MD
Markus Bookland, MD, FAANS
Gary Spiegel, MD
Belachew Tessema, MD
Katie Kellerman, M.Hs, PA-C
Petronella Stoltz, APRN, DNP
56
Orthopaedic Surgery
The Orthopaedic Division continues to grow both clinically
and academically. An all-star team ranging from surgeons to
sports trainers to engineers provides quality care for the full
spectrum of orthopaedic conditions to improve the quality of
health for members of our community.
The Orthopaedic Division consists of three services: the pediatric orthopaedic service, a sports medicine service (Elite Sports
Medicine), and the Center for Motion Analysis (CMA). The pediatric orthopaedic service has seven fellowship-trained pediatric orthopaedic surgeons, two physicians’ assistants, and one
advanced-practice registered nurse. Together, our services provide the full spectrum of care for children and young adults with
orthopaedic conditions such as scoliosis and spinal deformities,
limb deformity, congenital dislocated hips, clubfeet, congenital
hand deformities, children’s fractures, sports injuries, as well as
neuromuscular conditions such as cerebral palsy, spina bifida
and muscle diseases.
Residents are taken through a core curriculum of pediatric orthopaedic topics to supplement their clinical and surgical experience. An ACGME-accredited pediatric orthopaedic fellowship
helps train the next generation of subspecialists. Journal clubs
for the entire clinical staff keep the team up to date on the
latest literature and promote a cohesive environment for the
care team. Departmental and interdisciplinary conferences with
radiology and neurosurgery promote multi-specialty collaboration. Dr. Kristan Pierz now serves as editor of the POSNA Resident Review, an important educational asset for surgeons-intraining.
The sports medicine service (Elite Sports Medicine) continues
to grow under the guidance of four physicians, two physicians’
assistants, and two athletic trainers. This group provides outstanding care for young athletes with injuries and oversees
impressive sports injury prevention and concussion programs.
The CMA continues to expand its scope of practice, both clinically and in the area of research. In June of 2014, the Center
for Motion Analysis hosted the 24th annual gait course entitled: Clinical Gait Analysis: A Focus on Interpretation, which
was attended by 85 medical providers from all over the world.
This AMA Category 1 course was 3½ days in length and included the following faculty: Sylvia Õunpuu MSc, Kristan Pierz,
MD, Jeffrey Thomson, MD, Janet Zahradnik, MD, Philip Mack,
MD, Matthew Solomito, MS, and Erin Garibay, MS. Research
in the CMA currently includes multiple collaborations includ-
ing outcomes for patients with cerebral palsy with the Functional Assessment Research Group with 6 other children’s
hospitals, research on concussion with CHLA and University
of Oregon, and in pain management in young adult females
with Cincinnati Children’s Hospital. Funded research also includes analysis of orthopaedic surgical outcomes using motion analysis techniques in patients with Charcot-Marie-Tooth
and recurrent clubfoot deformity as well as evaluation of return-to-sport decision-making following ACL reconstruction.
Our research program, under the direction of Matthew Solomito, has been increasingly busy. Our three services have 47
active IRB studies underway with over 30 additional projects
in progress. Collaboration in multicenter studies gives us access to the latest protocols for difficult diseases. Grants from
Major League Baseball, Centers for Disease Control, and
POSNA help us provide evidence-based guidelines for topics such as ideal pitching mechanics and return-to-play after
ACL reconstruction. Summer research programs educate
college and medical students on the scientific process.
The Orthopaedics Division continues to benefit from the generosity of Geno Auriemma’s Fore the Kids charity golf tournament, which is co-chaired by Mr. Brien Beakey and Mr. Joe
Campanisi. This year we expect another successful tournament, which will result in over $1 million dollars being raised
over 10 years.
PUBLICATIONS
Presciutti SM, Karukanda T, Lee M. Management decisions for
adolescent idiopathic scoliosis significantly affect patient radiation exposure. Spine J. 2014;14(9):1984–1990. doi:10.1016/j.
spinee.2013.11.055.
Davis RB III, Õunpuu S, DeLuca PA. Analysis of gait. In: DR
Peterson and JD Bronzino, editors. Biomechanics: principles and
practices. Boca Raton: CRC Press; 2014 Dec. p. 5:1-13.
Talusan PG, Milewski MD, Wall EJ. Osteochondritis dissecans
of the talus in athletes. Clin Sports Med. 2014.
Milewski MD, Skaggs DL, Bishop GA, Pace JL, Ibrahim DA,
Wren TAL, Barzdukas A. Sleep deprivation is associated with increased risk of sports injuries in adolescent athletes. J Pediatr
Orthop. 2014.
Reach JS, Perez JL, Milewski MD, Talusan PG. Anterior ankle
impingement syndrome. J Am Acad Orthop Surg. 2014.
57
Orthopaedic Surgery
Chu A, Chaudhry S, Sala D, Atar D, Lehman W. Calcaneocuboid arthrodesis for recurrent clubfeet: what is the outcome at
17-year follow-up? J Child Orthop. 2014(8):43-48.
Chaudhry S, Phillips D, Feldman D. Legg-Calvé-Perthes
Disease: an overview with recent literature. Bull Hosp Jt Dis.
2014;72(1).
BOOKS
Milewski MD, Nissen CW, editors. Osteochondritis dissecans:
diagnosis and treatment options for athletes: an issue of clinics in
sports medicine. Philadelphia: Elsevier; 2014 Apr.
BOOK CHAPTERS
Pensak MJ, Lee MC, Bayron JA, Thomson JD. Utility of early
post-operative radiographs after posterior spinal fusion for adolescent idiopathic scoliosis. Spine. 2014 Apr 10.
Nissen CW. Knee injuries in skeletally immature athletes. In:
Miller M, Thompson S, editors. DeLee & Drez’s Orthopaedic
Sports Medicine. Elsevier; 2014 Apr.
O’Malley M, Solomito MJ, Milewski MD. The association of
tibial slope and ACL rupture in skeletally immature patients. J
Arthroscop Rel Surg. 2014.
STAFF
Kostyun RO, Milewski MD, Hafeez I. Sleep disturbance
and neurocognitive function during the recovery of a sport-related concussion in adolescents. Am J Sports Med. 2014.
Sonia Chaudhry, MD
Janet Zahradnik, MD
Imran Hafeez, MD
Amy Shannon, APRN
Rethlefesen SA, Nguyen DT, Wren TA, Milewski MD, Kay RM.
Knee pain and patellofemoral symptoms in patients with cerebral
palsy. J Pediatr Orthop. 2014.
Mark C. Lee, MD
Bruce E. Bowman, PA-C
Philip W. Mack, MD
Nicole Cohle, PAC
Matthew D. Milewski, MD
Sylvia Õunpuu, MSc
Carl W. Nissen, MD
Marta Jablonski, PA-C
Kristan Pierz, MD
Kevin Fitzsimmons, PA-C
David Wang, MD
AJ Ricciuti, PA-C
Solomito M, Garibay E, Woods J, Õunpuu S, Nissen C.
Evaluation of wrist and forearm motion in college-aged baseball
pitchers. Sports Biomech. [published online] 2014 Sep 9; doi:10.
1080/14763141.2014.955523.
Matava M, Arciero R, Baumgarten K, Carey J, DeBerardino T,
Hame S, Hannafin J, Miller B, Nissen C, Taft T, Wolf B, Wright R.
The MARS Group. Multirater agreement of the causes of ACL
reconstruction failure: a radiographic and video analysis of the
MARS Cohort. Am J Sports Med. 2014 Dec.
Keller TC, Tompkins M, Economopoulos K, Milewski MD, Gaskin C, Brockmeier S, Hart J, Miller MD. Tibial tunnel placement
accuracy during anterior cruciate ligament reconstruction: independent femoral versus transtibial femoral tunnel drilling techniques. Arthroscopy. 2014 Jun 4. pii: S0749-8063(14)00282-5.
Milewski MD, Nissen CW. Preface. Clin Sports Med. 2014
Apr;33(2):xiii-xiv.
Economopoulos KJ, Milewski MD, Hanks JB, Hart JM, Diduch DR. Radiographic evidence of FAI in athletes with sports
hernias. Sports Health. 2014 Mar;6(2):171-7.
Jeffrey D. Thomson, MD
Division Head
58
Otolaryngology
Since the founding of the division in 1999, we have had
significant growth. What started as a one-surgeon practice in September 1999 is now the state’s largest group of
fellowship-trained pediatric otolaryngologists that includes
Drs. Valerie Cote, Christopher Grindle, Katie Kavanagh, Nicole Murray, Scott Schoem and Tulio Valdez.
To expand our capacity and improve our care for patients, we
have two current advanced practitioners, Rebecca Strong,
APRN, and Meaghan Krajewski, APRN. Christine Harrington,
PA-C, joins our practice in mid-April from National Children’s
in Washington, D.C. We are starting the process toward fellowship accreditation in pediatric otolaryngology.
The field of otolaryngology – head and neck surgery – has
expanded widely over the past decade with improvements in
surgical care, refinement and miniaturization of instrumentation, use of minimal incision surgery, and advancement of endoscopic techniques replacing traditional open surgical techniques. This has revolutionized management of sinus disease
and airway disorders. Technologic advancements in cochlear
implantation have enabled children who are deaf to develop
excellent speech and integrate into mainstream society.
Currently, the division has thriving sub-specialty clinics in voice
and swallowing disorders, and cochlear implantation. In collaboration with the divisions of Pulmonary Medicine and Digestive Diseases, we have expanded the scope of the multidisciplinary Connecticut Children’s Airway Team. The Division
of Otolaryngology participates with General Surgery and
Endocrinology on the Pediatric Thyroid center. Patients and
families appreciate the improved time efficiency of combined
office appointments and operative procedures.
In addition, the division is involved in several new collaborations: MIT Spectroscopy Laboratory, the UConn Computer
Science Department, and with Anesthesiology instructing
residents via medical simulation.
PUBLICATIONS
Cote V, Prager JD. Iatrogenic phenol injury: a case report
and review of medication safety and labeling practices with
flexible laryngoscopy. Int J Pediatr Otorhinolaryngol. 2014
Oct;78(10):1769-73. doi: 10.1016/j.ijporl.2014.07.007. Epub
2014 Jul 12.
Grindle CR. Pediatric hearing loss. Pediatr Rev. 2014
Nov;35(11):456-63; quiz 464. doi: 10.1542/pir.35-11-456.
Marom T, Joseph RA, Grindle CR, Shah UK. Tracheotomy
after laryngotracheopasty: risk factors over 10 years, J Pediatr Surg. 2014 Aug;49(8):1206-9. doi: 10.1016/j.jpedsurg.2013.11.065. Epub 2013 Nov 28.
Lawrason Hughes A, Murray N, Valdez TA, Kelly R, Kavanagh K. Development of the Connecticut Airway Risk Evaluation (CARE) system to improve handoff communication in
pediatric patients with tracheotomy. JAMA Otolaryngol Head
Neck Surg. 2014 Jan; 140(1):29-33.
Schoem SR, Rosbe K. Aerodigestive foreign bodies and
caustic ingestion. In: Cummings, et al, editors. Textbook on
otolaryngology – head and neck surgery. 2014.
Schoem SR, Bennett N, Johnson K. Complications of otitis
media. In: Infectious diseases in pediatric otolaryngology – a
practical guide. Springer; 2015.
Chandy BM, Valdez TA, Lim M. Invasive fungal sinusitis in
immunocompromised pediatric patients. Multi-resistant infections. In: Pediatric otolaryngology XIII IAPO manual of pediatric otolaryngology. San Paulo: Rettec Artes Graficas; 2014.
p34-7.
Valdez TA, Pandey R, Spegazzini N, Longo K, Roehm C,
Dasari RR, Barman I. Multiwavelength fluorescence otoscope
for video-rate chemical imaging of middle ear pathology. Analyt Chem. 2014;86:10454-60.
STAFF
Scott Schoem, MD
Division Head
Valerie Cote, MD, FRCSC
Rebecca Strong, APRN
Christopher Grindle, MD
Meaghan Krajewski, APRN
Katie Kavanagh, MD
Christine Harrington, PA-C
Nicole Murray-Posner, MD
Tulio Valdez, MD
59
Pain & Palliative Medicine
Our mission is to utilize our multidisciplinary expertise to
alleviate pain and stress in children afflicted with acute,
chronic or terminal illness.
Connecticut Institute for Clinical and Translational Science:
Sickle Cell Hemoglobinopathies and Bone Health 1/1/146/30/15 Zempsky Co-I
Highlighting our year has been the addition of new faculty
members Kalyani Raghavan, MD, who was the Director of
Pediatric Sedation at Children’s Hospital of Michigan. Dr.
Raghavan will support our efforts in Acute Pain and Sedation. She also plans to develop a therapeutic yoga program
at Connecticut Children’s. Drs. Kathy Kalkbrenner and Jessie
Sturm from the Divisions of Hospitalist Care and Emergency
Medicine respectively have joined the division on a part-time
basis to provide Sedation Services.
Connecticut Institute for Clinical and Translational Science:
Genotypic Determinants of RBC Adhesion and Pain Severity
in Sickle Cell Disease 1/1/14-6/30/15 Zempsky Co-I
Other important highlights and milestones for the division for
2014 included:
Jessica Guite, PhD, was promoted to Associate Professor
in the Department of Pediatrics
Renee Manworren, RN, PhD, was named to the Board of
Directors of the American Pain Society
Ana Verissimo, MD, published her first book A Guide to
Integrative Pediatrics for the Healthcare Professional
William Zempsky, MD, published his first book the Oxford
Textbook of Paediatric Pain
William Zempsky, MD, received three new grants to support
his research in pain and sickle cell disease
•
•
•
•
•
NEW GRANTS
Donaghue Foundation Research Relevant and Ready: SEED
Greater Understanding of Sickle Cell Disease 4/1/1410/1/15 Zempsky PI
PUBLICATIONS
Guite JW, Kim S, Chen C-P, Sherker JL, Sherry DD, Rose
JB, Hwang W-T. Pain beliefs and readiness to change among
adolescents with chronic musculoskeletal pain and their
parents before an initial pain clinic evaluation. Clin J Pain.
2014;30(1):27-35. PMCID: PMCPMC 3742695. Guite JW, Kim S, Chen C-P, Sherker JL, Sherry DD, Rose
JB, Hwang W-T. Treatment expectations among adolescents
with chronic musculoskeletal pain and their parents prior to
an initial pain clinic evaluation. Clin J Pain. 2014;30(1):17-26.
PMCID: PMCPMC 3742613.
Samuels J, Manworren RCB. Determining the value of
post-operative pain management using timed electronic data.
Nurs Econ. 2014;32(2):80-88, 98.
Jain G, Mahendra V, Singhal S, Dzara K, Pilla TR, Manworren R, Kaye AD. Long-term neuropsychological effects of
opioid use in children: a descriptive review. Pain Physician.
2014;17:109-18.
Drew D, Gordon D, Renee L, Morgan B, Swensen H, Manworren RCB. The use of “as-needed” range orders for opioid
analgesics in the management of pain: a consensus statement
of the American Society of Pain Management Nurses and the
American Pain Society. Pain Manag Nurs. 2014;15(2):551-4.
Sanghamitra MM, Verissimo AM. A guide to integrative pediatrics for the healthcare professional. Houston, TX: Springer
Briefs in Public Health; 2014.
Zempsky WT, O’Hara EA, Santanelli JP, New T, Smith-Whitley K, Casella J, Palermo TM. Development and validation of
the youth acute pain functional ability questionnaire (YAPFAQ). J Pain. 2014 Dec;15:1319-27.
Bromberg MH, Schechter NL, Nurko S, Zempsky WT, Schanberg LE. Persistent pain in chronically ill children without detectable disease activity. Pain Manag. 2014 May;4(3):211-9.
60
Pain & Palliative Medicine
Mcgrath PJ, Stevens BJ, Walker SM, Zempsky WT, editors.
Oxford textbook of paediatric pain. United Kingdom: Oxford
University Press; 2014
Zempsky WT. Topical anesthetics and analgesics. In: Oxford
textbook of paediatric pain.
STAFF
William T. Zempsky, MD, MPH
Division Head
Len Comeau, MD
Kalyani Raghavan, MD
Mcgrath PJ, Stevens BJ, Walker SM, Zempsky WT, editors.
United Kingdom: Oxford University Press; 2014. p.486-94.
J. Michael Connors, MD
Jessie Sturm, MD
Jessica Guite, PhD
Ana Verissimo, MD
Stevens BJ, Zempsky WT. Prevalence and distribution of
pain in children. In: Oxford textbook of paediatric pain.
Kathy Kalkbrenner, MD
Kim Kempner, APRN
Kim Kempner, APRN
Renee Manworren, PhD,
APRN
Mcgrath PJ, Stevens BJ, Walker SM, Zempsky WT, editors.
United Kingdom: Oxford University Press; 2014. p.12-19.
Kerry Moss, MD
61
Pathology
In 2014, the Department of Pathology and Laboratory Medicine continued its mission of providing the highest quality
laboratory services through excellence, innovation, integrity
and concern for quality care provided to patients.
Dr. Rebecca Williams recently resigned from the pathology
division of the department due to illness and shortly thereafter
succumbed to that illness. This was a significant loss to the
department since Dr. Williams had served with nationally recognized distinction as the Residency Program Director for 13
years. Dr. Fiel-Gan has assumed the Program Director role.
In the fall, the department added Dr. Anshu Trivedi. Dr. Trivedi
recently completed her training in the department and spent
the past year doing a fellowship in liver pathology.
Although the majority of the members within the department
provide services in Anatomic Pathology, there is a wide range
of subspecialization within that division of the department. The
current MD/PhD staff in Anatomic Pathology have subspecialization in neuropathology (3), cytopathology (8), pediatric
pathology (1), molecular pathology (1), and dermatopathology
(1). Additional members within AP have specialty skills in organ systems for which there is no board certification. These
include breast pathology, GI pathology, GU pathology, Gyn pathology, pulmonary pathology, head and neck pathology, and
soft tissue tumors. Additionally there are six members of the
department board certified in topathology providing support in
Hematology and Hematopathology. Two staff members provide support in Transfusion Medicine. One is board certified
in Transfusion Medicine and the other has specialty expertise
in Coagulation. There is one PhD board-certified member in
each of the following disciplines: Microbiology, Chemistry, Molecular Pathology/Cytogenetics, and Immunopathology.
Evolving applications of molecular diagnostics to neoplastic
and non-neoplastic diseases has put demands on the division of Cytogenetics and Molecular Diagnostics. The recent
alliance with MSKCC also has had an impact on molecular
diagnostics. It is anticipated that diagnostic and therapeutic
applications for malignant diseases will continue to expand.
To remain on the cutting edge of these applications in our
division of Molecular Diagnostics, a request was made for acquisition of equipment for next generation sequencing. The
needed equipment will be arriving in FY2015.
The department’s 12 residencies in Anatomic Pathology and
5 fellowship positions continue to be filled with highly qualified individuals. Graduates of the Educational Program have
continued to be successful in obtaining highly desirable fellowships on completion of their residency training program
in Pathology at Hartford Hospital or have gone on to find
attractive positions in the clinical practice of Pathology. The
residency program continues as a Hartford Hospital-only program that is not integrated with the University of Connecticut.
The program does rely on the university, however, for training residents in Renal Pathology and Electromicroscopy. Now
that the department has recruited a dermatopathologist, the
program no longer relies on training in Dermatopathology at
the university.
PUBLICATIONS
Glazewaski L, Maldonado Y, Hamilton P, Aslanzadeh J.
Comparison of ZEUS ELISA™ Borrelia VlsE-1/pepC10 IgG/
IgM test to the Immunetics C6 Peptide ELISA for detection of
antibody response to B. burgdorferi infection. 114th Annual
Meeting of the American Society for Microbiology; 2014.
Tetreault J, Smally AJ, Hamilton P, Aslanzadeh J. Reliability
of rapid strep antigen test on throat samples collected by the
BD ESwab for laboratory diagnosis of acute pharyngitis in
adult patient population. 114th Annual Meeting of the American Society for Microbiology; 2014.
Araneta III RN, Aslanzadeh J, Ratkiewicz I, Chamberlain B,
Voytek T. Evaluation of the Gen-Probe APTIMA HPV 16,
18/45 Genotype Assay® in women with high-risk HPV infections. 30th Annual Clinical Virology Symposium and Annual Meeting of the Pan-American Society for Clinical Virology; 2014.
Cartun RW. Negative reagent controls in diagnostic immunohistochemistry: do we need them? An evidence-based recommendation for laboratories throughout the world. [editorial]
App Immunohistochem and Mole Morph. 2014 Mar.
Trivedi A, Cartun RW, Ligato S. Immunohistochemical
expression of IMP3 in superficially invasive pT1 esophageal
adenocarcinoma (EAC) is associated with lymphovascular
invasion (LVI) and can help in the risk stratification of these
patients. Path – Res and Prac. 2014 Jan.
62
Pathology
Ciesielski T. Human case of Eastern equine encephalitis –
Connecticut 2013. Conn Epidemiol. 2014 Jul; V34(3):9-10.
Vafaii P, DiGiuseppe JA. Detection of B-cell populations
with monotypic light chain expression in cerebrospinal fluid
specimens from patients with multiple sclerosis by polychromatic flow cytometry. Cytometry Part B (Clin Cytom).
2014;86B:106-10.
Abarzua-Cabezas F, Earle J, Meraney A. Angiosarcoma of
the corpora cavernosa. Int J Urol. 2014, Jun;21(6):622-3.
doi:10.1111/iju.12385. [Epub 2014 Jan 9]
Doss M, Araneta R 3rd, Fiel-Gan M, Edelheit B. Cranial
nerve VI palsy as an initial presentation of necrotizing sarcomatoid granulomatosis in a 14-year-old female: case report
and literature review. Semin Arthritis Rheum. pii: S00490172(14)00166-8. doi:10.1016/j.semarthrit.2014.07.004.
[Epub ahead of print. 2014 Jul 17]
Khutti S, Burghart J, Newcomb P, Mandavilli S. PAX-8 immunohistochemical staining in mucinous neoplasms involving
ovary; a critical evaluation including comparison of monoclonal versus polyclonal antibodies. Arch Path Lab Med. 2014
Sep.
Feder HM, Liu J, Rezuke WN. Kikuchi disease in Connecticut. J Peditr. 2014;164:196-200.
Zhou Q, Wang L, Tannenbaum S, Ricci Jr. A, DeFusco P,
Hegde P. Pathologic response prediction to neoadjuvant
chemotherapy utilizing pre-treatment near-infrared imaging
parameters and tumor pathologic criteria. Breast Cancer Res.
2014;16:456.
Gipson KE, Rosinski DJ, Schonberger RB, Kebera C, Mathew
ES, Nichols F, Dyckman W, Courtin F, Sherburne B, Bordey
AF, Gross JB. Elimination of gaseous microemboli from cardiopulmonary bypass using hypobaric oxygenation. Ann Thoracic Surg. 2014 Mar; 97(3):879-86.
Levine C, Trivedi A, Thung SN, et al. Severe ductopenia and
cholestasis from Levofloxacin drug induced liver injury. A case
report and review. Semin Liver Dis. 2014;34(02):246-51.
Marti J, Trivedi A, et al. Calcified teleangiectatic hyperplastic
nodule associated with vascular malformation in a child. A
case report. Fetal Pedi Path. doi:10.3109/15513815.2014
.970264.
BOOK CHAPTERS
Borowitz MJ, DiGiuseppe JA. Acute lymphoblastic leukemia/lymphoblastic lymphoma. In: Orazi A, Weiss LM, Foucar
K, Knowles DM, editors. Knowles’ neoplastic hematopathology, 3rd ed. Lippincott, Williams & Wilkins; 2014. p. 1019-29.
STAFF
William T. Pastuszak, MD
Department Chief
Jaber Aslanzadeh, PhD
Srinivas Mandavilli, MD
Margaret Assaad, MD
Laila Mnayer, MD
Fabiola Balarezo, MD
Richard Muller, MD
Richard Cartun, PhD
William Rezuke, MD
Joseph
DiGiuseppe, MD, PhD
Andrew Ricci, MD
Jonathan Earle, MD
Zendee Elaba, MD
Mary Fiel-Gan, MD
Marilyn Kritzman, MD
Lisa Laird, MD
Saverio Ligato, MD
Gregory Makowski, PhD
Bela Mandavilli, MD
Donna Rose, MD
Peter Shen, MD
Bradford Sherburne, MD
Sara Song, MD
Anshu Trivedi, MD
Dean Uphoff, MD
Terry Voytek, MD
63
Plastic Surgery
Dr. Charles Castiglione was selected as Physician of the
Year for Connecticut Children’s, and was a Finalist for the
Hartford Healthcare Heroes Award. He was also President
of the New England Society of Plastic and Reconstructive
Surgeons for 2013-2014. Dr. Alan Babigian is now Vice
President of the NESPRS, and Dr. Orlando Delucia is the
President of the Connecticut Society of Plastic and Reconstructive Surgeons.
The Plastic Surgery Department provides clinical services at
the Connecticut Children’s Medical Center and at Hartford
Hospital. Our surgical volume has remained stable, and includes all types of plastic and reconstructive procedures. Our
plastic surgeons frequently collaborate with other surgical
specialists, providing state-of-the-art multidisciplinary surgical
care. Common surgical procedures performed include: complex wound closures including flaps and grafts, craniofacial
reconstruction, craniofacial fracture repair, cleft lip/palate reconstruction, breast surgery/reconstruction, body contouring,
skin/soft tissue tumor excision/repair, upper extremity/hand
surgery/reconstruction, and cosmetic surgery/non-surgical
cosmetic procedures.
The multidisciplinary Craniofacial Team at Connecticut Children’s, co-directed by Dr. Charles Castiglione of Plastic Surgery and Dr. Paul Kanev of Pediatric Neurosurgery, remains
a center of excellence. The team provides comprehensive
evaluation and treatment for patients of all ages with congenital or acquired deformities of the head and neck. Active
team members come from many disciplines, including Plastic
Surgery, Pediatric Neurosurgery, Pediatric Otolaryngology, Pediatric Dentistry, Orthodontics, Oral and Maxillofacial Surgery,
Pediatric Development, Social Work, and Speech and Language Pathology. Surgeries for cleft lip and palate are most
common. Craniosynostosis reconstruction, performed by Dr.
Castiglione of Plastic Surgery, and Drs. Kanev, Jonathan Martin, and Markus Bookland of Pediatric Neurosurgery, are also
common. In addition, the multidisciplinary Craniofacial Trauma
Team, under the leadership of Drs. Castiglione and Norman
Cavanagh, provides cutting edge treatment for all craniomaxillofacial injuries at both Connecticut Children’s and Hartford
Hospital.
Dr. Brian Allen joined the Plastic Surgery Department at Connecticut Children’s, Hartford Hospital, and THOCC. After
completing a full general surgery residency at UConn, Dr. Al-
len later spent three years training in Plastic Surgery at the
renowned program at Emory University. He is fully trained in
all aspects of Plastic Surgery including general Pediatric Plastic Surgery.
Four plastic surgeons, Drs. Duff Ashmead, Alan Babigian,
David Bass, and Steven Smith, are fellowship-trained hand
surgeons, and perform all types of upper extremity and hand
surgery. This includes trauma surgery, and reconstruction for
acquired and congenital deformities. These surgeons also
provide the majority of coverage for hand call at Hartford
Hospital and Connecticut Children’s.
Plastic surgeons are very involved in volunteer activities, including surgical mission trips. Drs. Babigian and Castiglione
are consultants for Iraq Star, providing surgical care to injured
veterans of the Iraq and Afghanistan wars. Dr. Bass continues
to make frequent mission trips to South America. Drs. Babigian and Castiglione traveled to Latacunga, Ecuador, and performed many surgeries, including burn reconstruction, hand
surgery, ear reconstruction, and cleft lip/palate surgeries. Finally, Dr. Castiglione serves on the Medical Advisory Board of
the Jorge Posada Foundation, a foundation supporting the
treatment of congenital craniofacial deformities.
Education is a large component of the Plastic Surgery Department’s activities. Residents from General Surgery, Orthopedic
Surgery, Urology, ENT, OMFS (UConn and St Raphael’s), and
Emergency Medicine rotate on the service. Medical students
also elect rotations on Plastic Surgery. Active teaching occurs during daily patient rounds, in the clinic/office setting, in
the ER, in the OR, and during planned teaching conferences.
Several residents and medical students also have expressed
interest in a career in Plastic Surgery, and two residents
matched at premier plastic surgery residency programs this
year. This brings the total to 44 of our residents and students
who have moved on to Plastic Surgery since 1988 when
Dr. Castiglione began practicing here. Several residents and
medical students are involved in research projects with Drs.
Babigian and Castiglione. Drs. Babigian and Castiglione have
had several publications this year, and have presented papers
locally, regionally, and nationally. Dr. Castiglione is the Plastic Surgery editor for Connecticut Medicine: The Journal of
the Connecticut State Medical Society, and a reviewer for
both The American Journal of Cosmetic Surgery and Craniomaxillofacial Trauma & Reconstruction. Some department
64
Plastic Surgery
members are involved in local, regional and national professional societies. Drs. Castiglione and Delucia are members of
the Executive Council of the Connecticut Society of Plastic
and Reconstructive Surgeons, and Dr. Delucia is President.
Drs. Babigian and Castiglione are members of the Executive
Council of the New England Society of Plastic and Reconstructive Surgery, and Dr. Castiglione was the 2013-2014
Society President, while Dr. Babigian has become the Vice
President.
PUBLICATIONS
Ferneini E, Castiglione C, Forte P, Tinsley J, Wrubel J. Medical malpractice reform: exploring opportunities for improvement. Conn Med. Jan 2014;78(1):41-5.
Ferneini E, Castiglione C, Forte P, Tinsley J, Wrubel J. Medical malpractice reform: more choices for improvement. Conn
Med. Feb 2014;78(2):95-8.
STAFF
Charles L. Castiglione, MD, MBA, FACS,
Division Chief
Brian Allen, MD
Duffield Ashmead, MD
Alan Babigian, MD
David Bass, MD
Norman Cavanagh, MD, DMD
Alex Cech, MD
Orlando Delucia, MD
Steven Smith, MD
Mindi Cieck, APRN
Mary Eileen Auclair, PA-C
Paul Christopher Polzella, PA-C
65
Pulmonary Medicine
The Division of Pulmonary Medicine strives to be a comprehensive regional resource for pediatric pulmonary disease, with commitments to expert patient care, professional
and patient education, and clinical and basic research. This
year’s highlight was the recruitment of a sleep specialist, Dr.
Jay Kenkare, and opening of an accredited Pediatric Sleep
Laboratory.
The Division of Pulmonary Medicine provides care for infants,
children and adolescents with a variety of pulmonary diseases
including asthma, apnea, bronchopulmonary dysplasia, cystic
fibrosis, interstitial lung disease, neuromuscular disease, respiratory sleep disorders, and chronic respiratory failure. The
division oversees a state-of-the-art pulmonary function laboratory that is capable of performing spirometry, body plethysmography, impulse oscillometry, methacholine challenge,
cardiorespiratory adaptation, and exercise provocation testing
in children. Simple spirometry and bronchodilator assessment
also are performed at our satellite clinics.
Dr. Jay Kenkare joined the division this year, coming to us
from Gaylord Sleep Medicine. A certified sleep specialist
and member of the American Academy of Sleep Medicine,
Dr. Kenkare led the accreditation of our new 5-bed Pediatric Sleep Laboratory, with an accompanying increase in sleep
studies from 350 to over 800 per year. Dr. Kenkare also has
initiated a pediatric sleep clinic for the evaluation and treatment of children with respiratory and non-respiratory sleep
problems.
Our Central Connecticut Cystic Fibrosis Center continues to
be one of the Top 10 CF centers in the country based on
combined pulmonary and nutritional outcomes. Its director,
Dr. Craig Lapin, continued to serve as the Pediatric Program
Directors’ Representative to the Cystic Fibrosis Foundation’s
Center Director Committee, as well as being a member of the
Cystic Fibrosis Foundation Guidelines Steering Committee,
and of the Cystic Fibrosis Foundation’s Data Safety Monitoring Board. He co-chaired the Physician Grand Rounds and a
workshop on the E-Patient Experience at the 2014 NACFC.
Center Co-director, Dr. Melanie Collins, co-chaired a symposium on Care of the Young Child with CF at 2014 NACFC.
The center remains part of the CF Therapeutic Development
Network.
Our Pediatric Pulmonary Fellowship program graduated one
fellow in June 2014 and has a second fellow completing
training this year. Members of the division also contributed to
the education of medical students and residents, respiratory
therapists, and nursing APRN students from Yale. Dr. Craig
Schramm continued to serve on the Pediatric Chest Medicine
Network Steering Committee of the American College of
Chest Physicians and as a member of the University Center
for Excellence in Developmental Disabilities at the University
of Connecticut Health Center. Our certified asthma educator,
Rosalyn Bravo, APRN, served as the Program Chair of the
Connecticut chapter of the National Association of Pediatric
Nurse Practitioners.
Clinical collaborations included a Sickle Cell Pulmonary Clinic
with Hematology-Oncology and an Aerodigestive Clinic with
ENT and Gastroenterology. Clinical research projects conducted over the past year included comparison of impulse
oscillometry with clinical asthma scores and participation in
multi-center trials involving ivacaftor and lumacaftor in children with cystic fibrosis. Collaborative research projects focused on clinical obesity with Endocrinology, clinical asthma
research with Intensive Care Medicine, microbiological research in cystic fibrosis with Quinnipiac Medical School, and
weaning of supplemental oxygen in infants with bronchopulmonary dysplasia with Boston Children’s Hospital. Additional
basic science research addressed mechanisms of airway
immunological tolerance with the Department of Immunology and microRNA expression in asthmatic airways with the
Jackson Laboratory for Genomic Medicine in Farmington.
PUBLICATIONS
Carroll CL, Coro M, Cowl A, Sala KA, Schramm CM. Transient occult cardiotoxicity in children receiving continuous beta-agonist therapy. World J Pediatr. 2014 Nov;10(4):324-9.
Lodha A, Sauve R, Bhandari V, Tang S, Christianson H, Bhandari A, Amin H, Singhal N. Need for supplemental oxygen at
discharge in infants with bronchopulmonary dysplasia is not
associated with worse neurodevelopmental outcomes at 3
years corrected age. PLoS ONE 2014 Mar 19;9(3):e90843.
Natarajan P, Guernsey LA, Schramm CM. Regulatory B
cells in allergic airways disease and asthma. Methods Mol
Biol. 2014 July;1190:207-25.
Simoneau T, Bazzaz O, Sawicki GS, Gordon C. Vitamin D
status in children with cystic fibrosis. Associations with inflammation and bacterial colonization. Ann Am Thorac Soc. 2014
Feb;11(2):205-10.
66
Pulmonary Medicine
STAFF
Umit Emre, MD
Craig Schramm, MD,
Division Head
Jay Kenkare, MD
Anita Bhandari, MD
Melanie Sue Collins, MD
Craig Lapin, MD
Tregony Simoneau, MD
Rosalynn Bravo, APRN
67
Radiology
The Division of Radiology provides a full spectrum of imaging services as well as minimally invasive image-guided
therapy to all clinical divisions at Connecticut Children’s
Medical Center. The department is an “Image Gently” facility using strategies to minimize radiation to our patients
while utilizing best practice standards and appropriateness
criteria to best evaluate children.
Imaging modalities range from computed radiography and digital radiography to complex magnetic resonance imaging. The
department is accredited through the American College of Radiology in Ultrasound, CT and MRI. Nuclear Medicine services
are provided through collaboration with Hartford Hospital. Image guided therapies are provided through collaboration with
physicians from Jefferson Radiology and Hartford Hospital
in Interventional Radiology and Interventional Neuroradiology.
With collaboration and support from the Divisions of Anesthesia
and Sedation Services, more image-guided procedures are being performed on site at Connecticut Children’s Medical Center
allowing for less disruption of care in a safer environment.
The department of Radiology has seen major replacements
and upgrading of imaging equipment. In 2014, a new digital radiography room was installed for the Emergency Department,
which allows better plain film imaging with approximately 40%
dose reduction. Three new Siemen’s ultrasound units were purchased and put into service allowing for superior imaging in a
modality that is well suited to our pediatric population. A new
Siemen’s flat panel fluoroscopy unit was installed allowing for
significant radiation dose reduction with improved image quality. These upgrades support the philosophy of the department
as an “Image Gently” and “Step Gently” facility to provide appropriate imaging while reducing the effects of ionizing radiation
as much as possible. Video goggles were provided by a donor
through the Foundation. They can be worn by a child in the MR
unit who can watch a movie while having a lengthy imaging
procedure with less dependence on sedation.
Dr. Moote is collaborating with Dr. Jeffrey Hyams in the Division
of Gastrointestinal Diseases to support multicenter grant-funded research evaluating the impact of MR imaging of children
with inflammatory bowel disease.
Dr. Baldwin is involved in a COG multicenter collaborative assessing impact of pulmonary nodule detection in patients with
sarcoma.
The Division of Radiology provides resident education in Pediatric Radiology to radiology residents from the University of
Connecticut Health Center, Hartford Hospital, and the Hospital
of St. Vincent’s in Bridgeport, CT. Pediatric residents and medical students from the University of Connecticut attend elective
rotations in the department. The radiology attendings provide
didactic lectures to the radiology and pediatric residents as
well as case review sessions. Teaching and clinical care conferences are held in collaboration with Divisions of Pulmonary
Medicine, Digestive Diseases, Endocrinology, General Surgery,
Hematology-Oncology, Orthopedic Surgery, and Urology, as
well as the NICU and PICU. Work conferences are provided
weekly to the Pediatric House Staff.
PUBLICATIONS
Garcia CM, Boe S, Coughlin B, O’Sullivan DM, Moote D,
O’Loughlin MT. The impact of enteric contrast on radiologist confidence in intravenously enhanced MDCT of the abdomen and pelvis: a randomized controlled trial. Adv Comput
Tomogr. 2014 June;3:18-23.
68
Radiology
BOOK CHAPTER
STAFF
Shah RP, Hallisey MJ. Venous angioplasty and stents. In:
Handbook of interventional radiologic procedures, 5th ed.
Little, Brown & Co.
R. Timothy Brown, MD
Division Head
Michael Baldwin, MD
W. Steven Poole, MD
Frederick U. Conard, MD
Ron Rosenberg, MD
Michael Hallisey, MD
Margaret Szerejko, MD
Josh Kallen, MD
Greg Wrubel, MD
Michael Thomas O’loughlin
David Zimmerman, MD
Douglas Moote, MD
Patrick Deegan, PA
69
Research
The four faculty members of the Division of Research conduct high quality clinical/translational research and clinical
trials, and prepare proposals for external funding to advance
the overall research enterprise of Connecticut Children’s
Medical Center.
They are assisted in this work by more than 30 professionals, including an expert group of master’s prepared research
associates and divisional research managers, certified study
coordinators and skilled sponsored-program administrators
and analysts. The division also manages a unique Investigator
Support program for new and established investigators that
has yielded 6 NIH Mentored Scientist (K) awards and a 60%
R01 funding rate.
Highlights of 2014 include the promotion of Dr. Georgine
Burke to the rank of Professor in the School of Medicine and
appointment to the editorial board of Inflammatory Bowel
Diseases. Dr. Elizabeth Brownell joined the editorial review
board of the Journal of Human Lactation, was appointed to
the national Baby-Friendly NICU Task Force, and served as
Co-Chair of the Maternal Child Health Data and Epidemiology Committee of the American Public Health Association.
PUBLICATIONS
Brownell EA, Hagadorn JI, Lussier MM, Goh G, ThevenetMorrison KN, Lerer TJ, Herson VC, Howard, CR. Optimal periods of exclusive breastfeeding to predict any breastfeeding
duration through one year. J Pediatr. [in press] (Epub ahead
of print Dec. 16, 2014. doi:http://dx.doi.org/10.1016/j.
jpeds.2014.11.015.)
Valdez TA, Marvin K, Bennett NJ, Lerer T, Nolder AR,
Buchinsky FJ. Current trends in perioperative antibiotic use: a survey of otolaryngologists. Otolaryngol Head
Neck Surg. [in press] (Epub ahead of print Oct 10, 2014.
doi:10.1177/0194599814554551.)
Goyal A, Hyams JS, Lerer T, Leleiko NS, Otley AR, Griffiths
AM, Rosh JR, Cabrera JM, Oliva-Hemker MM, Mack DR, Rick
JN, Pfefferkorn MD, Carvalho R, Grossman AB, Hitch MC,
Sudel B, Kappelman MD, Saeed SA, Faubion WA, Schaefer
ME, Markowitz JF, Keljo DJ. Liver enzyme elevations within
three months of diagnosis of inflammatory bowel disease and
the likelihood of liver disease. J Pediatr Gastroenterol Nutr.
2014;59:321-3.
Sunseri W, Hyams JS, Lerer T, Mack DR, Griffiths AM, Otley
AR, Rosh JR, Carvalho R, Grossman AB, Cabrera J, Pfefferkorn
MD, Rick J, Leleiko NS, Hitch MC, Oliva-Hemker M, Saeed SA,
Kappelman M, Markowitz J and Keljo DJ. Retrospective cohort
study of methotrexate use in the treatment of pediatric Crohn’s
disease. Inflamm Bowel Dis. 2014;20:1341-5.
Chicaiza H, Hellstrand K, Lerer T, Smith S, Sylvester F. Potassium hydroxide: an alternative reagent to perform the modified Apt Test. J Pediatr. 2014;165:628-30.
Markush D, Briden KE, Chung M, Herbst KW, Lerer TJ, Neff
S, Wu AC, Campbell BT. Effect of surgical subspecialty training on patent ductus arteriosus ligation outcomes. Pediatr
Surg Int. 2014;30:503-9.
Cortezzo DM, Sanders M, Brownell E, Moss K. End-of-life
care in the neonatal intensive care unit: experiences of staff
and parents. Am J Perinatol. 2014 Dec 17. [Epub ahead of
print]
Hagadorn JI, Brownell EA, Lussier MM, Parker MGK, Herson VC. Variability of criteria for pasteurized donor human milk
use: a survey of US neonatal ICU medical directors. JPEN J
Parenter Enteral Nutr. 2014 Sep 29. [Epub ahead of print]
Brownell EA, Lussier MM, Bielecki D, Proulx TA, Esposito
P, Briere CE, Herson VC, Hagadorn JI. Patterns and predictors of donor human milk non-consent in the neonatal ICU.
Breastfeed Med. 2014 Oct; 9:393-7.
Dozier AM, Brownell EA, Guido J, Yang H, Howard CA, Doniger A, Ossip D, Lawrence R. Adapting the pregnancy risk
assessment monitoring survey to enhance locally available
data: methods. Matern Child Health J. 2014 Jul; 18(5):1196204.
Brownell EA, Lussier MM, Dozier AM, Howard CR, Fisher
SG, Duckett JW, Lawrence RA, Fernandez ID. The discordance between planned use and actual receipt of immediate
postpartum depot medroxyprogesterone among low-income
women. Breastfeed Med. 2014 Jun; 9:290-3.
Marinelli KA, Lussier MM, Brownell EA, Herson VC, Hagadorn JI. The effect of a donor milk policy on the diet of very
low birth weight infants. J Hum Lact. 2014 Apr 18. [Epub
ahead of print]
70
Research
Dozier AM, Nelson A, Brownell EA, Howard CR, Lawrence
RA. Patterns of postpartum depot medroxyprogesterone administration among low-income mothers. J Womens Health
(Larchmt). 2014 Mar; 23(3):224-30.
Sylvester F, Draghi A, Marina A, Marina F, Wang Z, Vella A.
A distinct colonic mucosal cytokine signature in new onset,
untreated pediatric Crohn’s disease. J Pediatr Gastroenterol
Nutr. 2014. PMID: 25000355.
Brownell EA, Lussier MM, Hagadorn JI, McGrath JM, Marinelli KA, Herson VC. Independent predictors of human milk
receipt at neonatal intensive care unit discharge. Am J Perinatol. 2014 Nov; 31(10):891-8.
Bühlmann P, Gertheiss J, Hieke S, Kneib T, Ma S, Schumacher M, Tutz G, Wang CY, Wang Z, Ziegler A. Discussion of
“The evolution of boosting algorithms” and “Extending statistical boosting.” Methods Inf Med. 2014 Nov 14; 53(6):436-45.
PMID: 25396219.
Brownell EA, Lussier MM, Herson VC, Hagadorn JI, Marinelli KA. Donor human milk bank data collection in North
America: an assessment of current status and future needs. J
Hum Lact. 2014 Feb; 30(1):47-53.
Wang Z, Ma S, Ching-Yun Wang C-Y, Zappitelli M, Devarajan P, Parikh C. EM for regularized zero inflated regression
models with applications to postoperative morbidity after cardiac surgery in children. Stat Med. 2014;33(29):5192-208.
http://dx.doi.org/10.1002/sim.6314.
Wang Z. mpath: Regularized linear models. R package version 0.1-14. 2014. http://cran.r-project.org/package=mpath.
STAFF
Georgine Burke, PhD
Division Director
Elizabeth Brownell, PhD
Jill Popp, PhD
Trudy Lerer, MS
Min Tang Schomer, PhD
Kathleen McKay, PhD
Zhu Wang, PhD
71
Rheumatology
The Division of Rheumatology is the largest such program
in the state, taking pride in our ability to be accessible to all
corners of the state. In 2013, referrals were received from
151 of the 169 towns in Connecticut.
The division is looking to expand and increase its academic
standings. With that in mind, the division recruited an
outstanding young physician, Dr. Heather Tory, who will
be splitting her time between rheumatology and patient
safety/quality, which will include ongoing research as well.
Rheumatology is also excited about recruiting a senior scientist,
Dr. Virginia Pascual, who has an international reputation in the
field of genomics in autoimmune disease, such as systemic
lupus, juvenile idiopathic arthritis, and Kawasaki disease. She
has demonstrated that blood gene expression profiling is a
valid approach to understanding the pathogenesis of human
systemic autoimmune diseases.
The mission of the division is to provide the best clinical care
possible to children with rheumatic disease, teach trainees
the basics of the field, and to enroll patients in clinical trials or
collaborative research projects when applicable. The addition
of Dr. Pascual will herald a new era of basic science research
at the University of Connecticut in the Division of Pediatric
Rheumatology.
We continue to run a high-volume practice; during 2014, we
saw the following number of patients:
1) New outpatients – 805 (additional 47 new patients at
Shriner’s satellite)
2) Follow-up visits – 1,850 (additional 194 follow-up patients
at Shriner’s)
3) Inpatient admissions - 27
4) Inpatient consults - 37
5) Joint aspirations - 82
Rheumatology collaborates with the sedation service around
procedures, orthopaedics for overlapping disorders, GI for
infusions and drug toxicities, hematology for disorders that
span both specialties, nephrology for lupus and vasculitis,
infectious disease for Lyme disease, and the pain service for
children with amplified pain disorders, such as fibromyalgia.
The division fully utilizes the resources of the hospital, since
many of the patients have multi-system disease or complex
psycho-social problems.
The division provides critical education to trainees, since
the outpatient rotation is often the only exposure pediatric
residents have with rheumatic disease. Eleven of the 13
blocks were subscribed by pediatric residents or fourthyear medical students on elective. Space permitting, we
occasionally accommodate outside residents, third-year
medical students, and even physician assistant students. We
have an arrangement with the Division of (adult) Rheumatology
at the University of Connecticut Health Center to provide their
fellows with pediatric training.
FACULTY
Lawrence Zemel, MD
Division Head
Barbara Edelheit, MD
Heather Tory, MD
72
Transplant Surgery
This year has been a very busy and productive one for the
Division of Transplant at Connecticut Children’s. Working
closely with the Division of Nephrology, the pediatric kidney
transplant programs continue to grow, and successful kidney transplants have been performed. Our multidisciplinary
approach has allowed us to successfully offer transplants
to more pediatric patients. The program is recognized by
UNOS.
We were named a Center of Excellence for Anthem and Aetna, attesting to the quality of our program.
The Transplant Division has a strong quality program. Each
program has a quality indicator dashboard as well as a Process Improvement dashboard which tracks PI projects such
as revisions of policies, decreasing infections, developing algorithms to improve patient care.
Matthew Brown, MD
STAFF
Patricia Sheiner, MD, FACS
Division Director
Anne Lally, MD
Caroline Rochon, MD
Brian Shames, MD
73
Urology
Again this year, U.S. News & World Report chose Connecticut Children’s Medical Center as one of the 50 top-ranked
centers for children with serious urological conditions.
Our ACGME-accredited fellowship program in pediatric urology continues to attract and train top candidates in our field.
Our first fellow, Miriam Harel, has joined Connecticut Children’s as a faculty member. She continues her work in basic
science research. Her work with Drs. Ferrer and Shapiro was
recognized with the basic science research prize at the Pediatric Urology Fall Congress. Dr. Harel now leads the urological
care in our specialty clinic for patients with posterior urethral
valves (PUV). Our second fellow, Liza Aguiar, is working on
her Master’s Degree in Clinical and Translational Research at
the University of Connecticut. In July 2015, she will join the
faculty at Brown University. Our third fellow, Paul Smith III, is
busy with training in his clinical year. Next year, his focus will
be on urodynamic evaluation in children. Our next fellow, Gina
Smith, will come to us from the residency program at Medical
College of Wisconsin. She joins the team in July 2015.
Pediatric Urology continues to develop the combined service line with Pediatric Nephrology. The service line remained
busy with over 12,500 patient visits and over 1,000 operative
cases performed. We led Connecticut in volume of pediatric
kidney transplantations.
Our service line provides joint clinic visits at both the Hartford and Farmington offices. We expanded our combined research endeavors in stone disease and patients with posterior
urethral valves.
We continue to enhance the specialty clinics at Connecticut
Children’s Medical Center. These include: GUPPE clinic for
patients with disorders of sexual development, ROCKS clinic
for patients with kidney stones, PUV clinic for patients with
posterior urethral valves, MVP (Managing Voiding Problems)
clinic for patients with bladder and bowel dysfunction, and
Prenatal clinic for patients with known fetal urological abnormalities. Our prenatal program has established care for
patients at University of Connecticut, Hartford Hospital, and
Danbury Hospital.
In 2015, we plan an expansion of services in more satellite locations. We will expand our didactic conferences
and integrate joint teleconferences with providers beyond
Connecticut.
PUBLICATIONS
Hamilton TE, Barnhart D, Gow K, Ferrer F, Kandel J, Glick
R, Dasqupta R, Naranjo A, He Y, Gratias E, Geller J, Mullen E, Ehrlich P. Inter-rater reliability of surgical reviews for
AREN03B2: A COG renal tumor committee study. J Ped
Surg. 2014;49(1):154-8.
Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA.
Treatment with the immunomodulator FTY720 (Fingolimod)
significantly reduces renal inflammation in murine unilateral
ureteral obstruction. J Urol. 2014;191(5):1508-16.
Ferrer FA, Herbst KW, Fernandez C, Khanna G, Dome
JS, Mullen EA, Geller JI, Gratias E, Shamberger R, Ritchey
M, Ehrlich PF. Feasibility of using CT volume as a predictor
of specimen weight in a subgroup of patients with low risk
Wilms tumors registered on COG study AREN03B2: implications for central venous catheter placement. J Ped Urol.
2014;10(5):969.
Mullen EA, Geller JI, Gratias EJ, Perlman EJ, Ehrlich PF,
Khanna G, Naranjo A, He Y, Hamilton TE, Ferrer FA, Glick
RD, Gow KW, Barnhart DC, Kandel JJ, Dasgupta R, Hoffer
FA, Servaes S, Fernandez CV, Grundy PE, Dome J. Realtime central review: a report of the first 3,000 patients enrolled on the Children’s Oncology Group Renal Tumor Biology
and Risk Stratification protocol AREN03B2. J Clin Oncol.
2014;32(15):10000.
Ferrer F. [editorial comment] J Urol. 2104.
Li MH, Harel M, Hla T, Ferrer F. Induction of chemokine
(CC motif) ligand 2 by sphingosine-1-phosphate signaling in
neuroblastoma. J Ped Surg. 2014;49(8):1286-91.
Harel M, Makari JH. Paratesticular inflammatory myofibroblastic tumor in a pediatric patient. Case Rep Urol. 2014; Article ID 303678.
Markush D, Briden KE, Chung M, Herbst KW, Lerer TJ,
Neff S, Campbell BT. Effect of surgical subspecialty training
on patent ductus arteriosus ligation outcomes. Ped Surg Intl.
2014 May; 30(5):503.
Mason MD, Herndon CA, Herbst KW, Poston TL, Brandt EJ,
Peters CA, Corbett ST. Proctor environment facilitates faculty
training in pediatric robotic-assisted laparoscopic pyeloplasty.
J Robotic Surg. 2014 Dec:8(4):365-9.
74
Urology
Herbst KW. [commentary] Emergency room visits and readmissions after pediatric urologic surgery. J Ped Urol. 2014
Aug; 10(4):716.
Campbell BT, Herbst KW, Briden KE, Neff S, Ruscher
KA, Hagadorn JI. Inhaled nitric oxide use in neonates with
congenital diaphragmatic hernia. Pediatrics. 2014 Aug;
134(2):e420-e6.
Herbst K, Corbett ST, Lendvay TS, Caldamone AA. Recent
trends in the surgical management of primary vesicoureteral
reflux in the era of dextranomer/hyaluronic acid. J Urol. 2014
May:191(5):1628-33.
Morrison K, Herbst K, Herndon CD. Pain management practice patterns for common pediatric urology procedures. Urology. 2014 Jan;83(1):206-10.
Smith PP, Chalmers DJ, Feinn RS. Does defective volume
sensation contribute to detrusor underactivity? Neurourol
Urodyn. 2014 Sep 14. doi:10.1002/nau.22653. [Epub ahead
of print] PubMed PMID: 25220925.
Moody BJ, Liberman C, Zvara P, Smith PP, Freeman K, Zvarova K. Acute lower urinary tract dysfunction (LUTD) following
traumatic brain injury (TBI) in rats. Neurourol Urodyn. 2014
Sep;33(7):1159-64. doi:10.1002/nau.22470. Epub 2013
Aug 29. PubMed PMID: 24038177.
Wolff GF, Kuchel GA, Smith PP. Overactive bladder in
the vulnerable elderly. Res Rep Urol. 2014 Oct 3;6:1318. doi:10.2147/RRU.S41843. eCollection 2014. Review.
PubMed PMID: 25328867.
Smith PP, Tyagi P, Kuchel GA, Pore S, Chermansky C, Chancellor M, Yoshimura N, Levanovich P. Advanced therapeutic
directions to treat the underactive bladder. Int Urol Nephrol.
2014 Sep;46 Suppl 1:35-44. doi:10.1007/s11255-0140809-8. Epub 2014 Sep 20. PubMed PMID: 25238893.
Tyagi P, Smith PP, Kuchel GA, de Groat WC, Birder LA, Chermansky CJ, Adam RM, Tse V, Chancellor MB, Yoshimura N.
Pathophysiology and animal modeling of underactive bladder.
Int Urol Nephrol. 2014 Sep;46 Suppl 1:11-21. doi:10.1007/
s11255-014-0808-9. Epub 2014 Sep 20. PubMed PMID:
25238890.
BOOK CHAPTER
Ramachandra P, Ferrer FA. Pediatric renal tumors. In: Pediatric urology for the primary care physician. New York: Springer;
2014.
STAFF
Fernando Ferrer, MD FAAP FACS
Division Chief
Jill Bernstein, MD, FAAP
Miriam Harel, MD
Christina Kim, MD, FAAP
John Makari, MD, FAAP, FACS
Eric Nelson, MD
Phillip Smith, MD
Katherine Herbst, MSc
75
Graduate Medical Education
Residency
As part of the program’s progress toward effectiveness in
the Next Accreditation System, the Pediatric Residency
Program revised its milestones-based assessments. During
the inaugural application of this approach, it became apparent that there was less narrative description, proportionate
to the number of areas of subcompetence assessed. There
was a need for faculty and residents to better understand
the rationale for the level of progress determined.
As a result, faculty members for each resident activity were
made responsible for many fewer areas of subcompetence
about which to assess the milestone levels reached, with
the expectation that the evaluations would provide more description of the performance that led to the assignment of
the milestone rating determined. Residents indicated that the
revised evaluations, providing more performance description,
were more useful for their understanding the basis of their
assessments, in knowing what to do to reach the next level
in their progression for each area of subcompetence and in
using the information in formulating their Individualized Learning Plans. Faculty members felt the revised assessments improved on the accuracy and usefulness the judgments made.
The results of the program changes were presented nationally at the Annual Spring Meeting of the Association of Pediatric Program Directors.
The restructuring of the curriculum, including the six rotationequivalent transitional experience, entered its second year.
Residents and faculty were adapting to the process, and the
built-in flexibility was greatly appreciated. The concentration/
pathway approach is serving its purpose of promoting resident
career preparation for the spectrum of possibilities in the time
frame needed for career decisions. The Ambulatory Pediatrics
Pathway was selected to be presented nationally at the Annual Spring Meeting of the Association of Pediatric Program
Directors by Drs. Terranova and Wallace, and it was very well
received. Dr. Sharon Smith has implemented her research curriculum as a resource to the pathways, and there has been a
marked increase in resident participation in research, as needed for most pathways.
PL-1s
Emily Biddick, MD
Abigail Bosk, DO
Crista Cerrone, MD
The new governance structure for the program, which includes
a Program Evaluation Committee (PEC) of core faculty leaders and elected residents to assess the program and make
recommendations to the Program Director and Chair regarding changes for the program, has gotten off to a strong start
under the leadership of Co-Chairs and Associate Program
Directors Drs. Skurkis and Smith. They succeeded in addressing all of the program improvement projects for their first year,
and are at work planning for next year’s improvements. The
Clinical Competence Committee (CCC), under the leadership
of Associate Program Director Dr. Mark Greenstein, reviewed
the applicants for the resident selection process for this year’s
Match, while conducting regular reviews of resident progress
using the milestone-based assessments of resident performance in the identified areas of sub-competence. The CCC
was instrumental in further refining the evaluation forms to
include fewer areas of subcompetence and expanding the
descriptive components. The work of CCC in the summative
milestone assessments during the past year has been very
successful, based on the lessons learned and changes made.
The program continued to successfully recruit high quality
residents, and the graduates again obtained outstanding
positions for the next steps in their careers. The program
first-attempt pass rate on the American Board of Pediatrics
certifying examination has increased once again, and it is
safely above average in meeting the required rate for accreditation. Participation in quality improvement continues
both in resident continuity experience and in the fabric of
Connecticut Children’s quality and safety efforts. Resident
participation research continues to increase as well, and we
expect even more participation with the new opportunities
related to pathway requirements for research. Next year, we
intend to further develop our training efforts for residents to
learn ways to increase their ability to have sustained wellbeing with career success and longevity, without sacrificing
their personal well-being.
Elizabeth Chasse, MD, MPH
Katie Clouthier, DO
Sarah Germani, DO
Jillian Gormley, DO
Tuhina Joseph, DO, MS
Annamarie Koller, DO
Selena Levine, DO
Katrina Loh, MD
76
Graduate Medical Education
Residency
David Muccino, MD, MPH
Shannon Oteri, DO
Carolina Quintana, MD
John Ramirez, MD
Amanda Silverio, MD
Kaitlin Strumph, DO
Whitney Trompeter, MD
Christine Yang, MD
Nancy Yip, DO, MS
PL-2s
Caroline Adegite, MD
Alyson Baker, MD
William Brucker, MD
Mary Ann De Banate, MD
Mona Doss, DO
Mark Gilroy, DO
Megan Griffiths, MD
Kunal Gupta, MD
Jane Im, MD
Rose Lee, MD
Laura McKay, MD
Adam Pascoe, MD
Alisha Philip, MD
Brenda Prindle, MD
Louis Rigos, DO
Melanie Rudnick, MD
Jessica Shui, MD
Vaka Sigurjonsdottir, MD
Kristopher Teti, MD
Sussi Vivar, MD
PL-3s
Rena Aroesty, MD
Jennifer Berrick, MD
Jennifer Dorr, DO, MPH
Rebecca Frontz, DO
Serwa Gyamfi, MD
Frank Han, MD
Lauren Jeffries, DO
Thomas Kennedy, MD
Paula Lucuara Revelo, MD
Sumith Madhavarapu, DO
Laurie Malia, DO
Nicholas Matarazzo, MD
Wallis Molchen, DO
Molly Naples, MD
Anna Weingarten, DO
Christine Pulice, DO
Aaron Slaiby, DO
Ginnie Taylor, MD
Carolyn Vitale, MD
Christen Vogel, MD
Chief Residents
Ruby Bartolome, DO
Clare O’Keefe, DO
Candice Sheldon, MD
77
Graduate Medical Education
Fellowship
The University of Connecticut School of Medicine-sponsored graduate medical education (fellowship) programs at
Connecticut Children’s Medical Center continue to graduate very well trained specialty physicians who enter practice
throughout the country. Our fellows continue to be awarded
funding for exciting research projects, with numerous accepted presentations at national scientific meetings, and
travel grants and awards received. The success of our Fellowship programs would not be possible without the dedication and tireless efforts of our Fellowship Coordinators:
Kathy Mikulak, Jack Wakefield, and Marianne Gonzalez.
ENDOCRINOLOGY
Led by Dr. Elizabeth Estrada, the program continued to
graduate fellows into academic programs. Fellows have had
a 100% pass rate at first attempt on the pediatric endocrinology board. They also are engaged in meaningful research
experiences mentored by well-published, NIH-funded investigators in basic and translational research. Our fellows continue to receive travel grants to attend national meetings to
present their work.
Dr. Hector Granados graduated from the program in 2014.
He gave a platform presentation on his work at the Pediatric
Academic Societies annual meeting. He also has received
travel grants to national meetings to present his research. His
work was titled “Type 1 Diabetes, Gut Bacteria and Immune
Connections.”
Dr. Sasi Penukonda is currently working on “Vanilloid Receptor 1 as regulator of gut immunity,” preliminary results of which
were presented at the American Association of Immunologists Annual Meeting in May 2014 in Pittsburgh, PA.
Dr. Sunitha Sura is currently studying the genetic link between
HDL cholesterol and subclinical atherosclerosis. Her project
involves studying Lymphocyte Activation Gene (LAG)-3 which
is an important immune modulator that mediates the association of Scavenger receptor-B1 genetic variant, rs10846744,
with subclinical atherosclerosis and incident cardiovascular
disease.
The fellowship is now led by Drs. Paola Palma Sisto and Rebecca Riba-Wolman, who have been active with the national
pediatric endocrine fellowship group on new assessment
tools for the ACGME’s Next Accreditation System requirements for fellowship.
EMERGENCY MEDICINE
Led by Dr. John Brancato, the Pediatric Emergency Medicine
Fellowship is now in its 14th year. The program welcomed
two excellent fellows in July: Kathryn Kasmire, MD, who joined
Connecticut Children’s from St. Christopher’s Hospital for
Children in Philadelphia, and our own resident Karl Hellstrand,
DO. The program also matched an excellent candidate, Hannah Sneller, MD, who will join Connecticut Children’s in July
2015 from Stony Brook Long Island Children’s Hospital.
Two of the program’s fellows, Henry Chicaiza, MD, and Talia
Brooks, MD, presented at the Pediatric Academic Societies
meeting in Vancouver and at the Eastern Society for Pediatric Research. Dr. Chicaiza’s two posters were on the use of
KOH as an alternative reagent for the modified Apt test, and
physical exam and patient historical factors associated with
pneumonia. Dr. Brooks presented on features of patients who
present to the Emergency Department with back pain.
Dr. Chicaiza joined another of our recent graduates, Jeffrey
Chen, MD, at Stony Brook University on Long Island.
Nationally, Dr. Brancato has been working with a subgroup of
the pediatric EM fellowship directors’ group to explore ways
of increasing fellowship pursuit by Emergency Medicine residency graduates.
UROLOGY
Led by Dr. Christina Kim, the Pediatric Urology Fellowship
Program continues to recruit and train excellent surgeons in
a very competitive field. In 2014, 20% of the fellowship programs did not initially match a candidate. We have proudly
matched top candidates at Connecticut Children’s since our
program’s inception.
Our first fellow, Miriam Harel, joined Connecticut Children’s as
a faculty member. In the past year, she continued her work in
Dr. Ferrer’s laboratory with a focus on renal tumor growth in
mice. She presented multiple abstracts on clinical outcomes
at the New England American Urological Association meeting and the Fall Congress for Pediatric Urology. Her laboratory work was recognized with the Basic Science Prize at the
Fall Congress for Pediatric Urology.
78
Graduate Medical Education
Fellowship
Her publications include:
Li MH, Harel M, Hla T, Ferrer F. Induction of chemokine
(CC motif) ligand 2 by sphingosine-1-phosphate signaling in
neuroblastoma. J Ped Surg. 2014;49(8):1286-91.
Harel M, Makari JH. Paratesticular inflammatory myofibroblastic tumor in a pediatric patient. Case Rep Urol. 2014; Article ID 303678.
Our second fellow, Liza Aguiar, is working on her Master’s Degree in Clinical and Translational Research at the University
of Connecticut. On a regional and national platform, she presented a multi-institutional experience of robotic bilateral ureteral reimplantations. Specifically, she presented at the New
England American Urological Association meeting and the
Pediatric Urology Fall Congress meetings. Additionally, she
has an accepted publication: A case of high grade transitional
cell carcinoma of the bladder in a pediatric patient with Turner
syndrome. Urology.
In July 2015, she will join the pediatric urology faculty at
Brown University.
Our third fellow, Paul Smith III, has been busy with his clinical training. Next year, he will focus on pediatric urodynamic
evaluations. Dr. Philip Smith will serve as his primary mentor
for this clinical training. Paul will also focus on outcomes research in the field of bladder and bowel dysfunction.
We are excited to welcome our next fellow, Gina Smith. Gina
is completing her residency training at Medical College of
Wisconsin. She will join us in July 2015.
NEONATAL-PERINATAL MEDICINE
Led by Drs. James Hagadorn and Jennifer Trzaski, the fellowship program in Neonatal-Perinatal Medicine continued
its track record of academic accomplishment and scholarly
productivity. Senior fellows Arvin Bundhoo and Soji Vargheses
are both on track to complete the fellowship program successfully. Dr. Bundhoo published his fellowship research as
first author in Clinical & Experimental Allergy, with Dr. Adam
Matson as research mentor and senior author. Dr. Varghese
is finalizing his research for submission for peer-review in
collaboration with mentors Dr. Naveed Hussain, Dr. Mariann
Pappagallo, and Dr. Elizabeth Brownell. Junior fellow Tristan
Lindberg presented his research to the Eastern Society for
Pediatric Research in Philadelphia and to the annual BY-
CONN (Brown/Yale/UConn) meeting, and will present to
the Pediatric Academic Societies in San Diego in April 2015.
Meanwhile, first-year fellow Kendall Johnson passed her pediatric boards and is now board-certified in that specialty. The
program continues to match well, and will welcome two strong
incoming fellows this July: Maushami Assad, MD, MPH, who
is completing her pediatric residency at Sinai Hospital in Baltimore, and Susan Pitts, MD, a pediatric resident at the Oklahoma State University Center for Health Sciences in Tulsa.
ORTHOPAEDICS
Led by Dr. Mark Lee, the Orthopaedics fellowship is relatively
new and was just accredited in 2013. The first fellow, Ali Maziad, has been part of the program since August of 2013 and
will be going on to an additional spine fellowship in August.
He is currently completing two research projects on operating room efficiency for elbow fractures, and pelvic fixation in
neuromuscular scoliosis. Ali received a first place award for
case presentations at the IEP (Spine Interactive Educational
Program) Fellows & Young Surgeons’ Annual meeting in November 2013. The program has filled the 2015 spot, and Dr.
Lee and his colleagues are excited to train another Pediatric
Orthopaedist for future practice.
GASTROENTEROLOGY
Led by Dr. Francisco Sylvester and Dr. Wael Sayej, the fellowship program in Pediatric Gastroenterology, Hepatology and
Nutrition has had four fellows since it started four years ago. Dr.
Sayej became the program director as of August 2014 after
the departure of Dr. Sylvester. The program graduated its first
fellow, Dr. Johanna G. Palmadottir, in June 2014. Dr. Palmadottir
has accepted a position as assistant professor of pediatrics at
the Medical University of South Carolina in Charleston. Dr. Palmadottir presented her work on the effect of colitis in muscle
stem cells at Digestive Diseases Week, the annual meeting of
the American Gastroenterological Association in May 2014 in
Chicago. Dr. Palmadottir won first prize in the Connecticut Children’s Fellows Research competition in 2013. The program will
be graduating its second fellow, Dr. Ajay Rana, in June 2015.
Dr. Rana has accepted a position with Eastern Maine Medical
Center, Bangor, ME. Dr. Rana is in the process of completing
his Masters in Clinical Investigation, and several projects that he
has carried on over the past 18 months. We are expecting our
fifth fellow, Dr. Angela Pressley-Wallace, to start in July 2014.
She is currently completing her pediatric residency at Arkansas
Children’s Hospital, University of Arkansas, Little Rock, AR.
79
Graduate Medical Education
Fellowship
She completed her medical education at Louisiana State University School of Medicine in New Orleans.
PULMONOLOGY
Led by Dr. Anita Bhandari, the Pediatric Pulmonary Fellowship currently has one fellow, Dr. Anne MacLaughlin, a thirdyear fellow. Her abstract titled “Asthma control scores correlate better with small airway than large airway dysfunction,”
has been accepted for poster presentation at the American
Thoracic Society Meeting in Denver, CO, in May. Dr. Michael
Blechner graduated in June 2014 and is pursuing a Pediatric
Sleep Fellowship at the Children’s Hospital of Philadelphia.
As a third year fellow, he presented a poster at the American
Thoracic Society meeting in San Diego in May 2014 titled
“Genotype predisposes African-American children to more
severe bronchiolitis.”
SURGERY
Led by Dr. Christine Finck, the fellowship program in Pediatric
General Surgery began in July 2011, and its first fellow, Dr.
Kimberly Ruscher, successfully began practicing in Eugene,
OR. She had several presentations during her fellowship and
was responsible for developing congenital diaphragmatic hernia surgical guidelines. The program’s new fellow, Dr. Anthony
Tsai, has a strong interest in innovation and minimally invasive
surgery.
GENETICS
Led by Dr. Joseph Tucker, the Pediatric Genetics fellowship,
which was first accredited in 1997, has graduated two fellows. The most recent graduate, Jennifer Gannon, completed
her fellowship training in June of 2013. Future development
of the program involves plans to expand to allow for a fouryear combined Pediatrics and Genetics training program, and
collaboration with Jackson Laboratories now located on the
campus of the University of Connecticut School of Medicine.
FELLOWS
Gasteroenterology
Pulmonology
Endocrinology
Johanna Palmadottir, MD
Michael Blechner, MD
Hector Granados, MD
Ajay Rana, MD
Anne McLaughlin, MD
Sasi Penukonda, MBBS
Jasmeet Mokha, MBBS
Sunitha Sura, MBBS
Victoria Grossi, DO
Shrinkhala Srivastava, MD
General Surgery
Anthony Tsai, MD
Neonatology
Emergency Medicine
DonnaMarie Cortezzo, MD
Urology
Henry Chicaiza, MD
Jeffrey Bartlett, DO
Miriam Harel, MD
Talia Brooks, MD
Soji Varghese, MD
Liza Aguiar, MD
Danielle Federico, MD
Arvin Bundhoo, MD
Paul “Trey” Smith, MD
Karl Hellstrand, DO
Tristan Lindberg, MD
Kathryn Kasmire, MD
Kendall Johnson, MD
Orthopaedics
Ali Maziad, MD
80
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Altman, Arnold
Leas’s Foundation for 5/1/14
Leukemia Research, Inc.
Leukemia
Research
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
n/a
n/a n/a
n/a
n/a
180821 Bennett, Nicholas
A Multicenter,
Cubist
Randomized, Pharmaceuticals, Inc
Double-blinded
Comparative
Study to Evaluate
the Efficacy,
Safety, and
Pharmacokinetics
of Daptomycin
Versus Active
Comparator in
Pediatric Subjects
With Acute
Hematogenous
Osteomyelitis Due
to Gram-Positive
Organisms
1/1/14
12/31/14
$7,250.00 2 of 3
n/a
n/a
180825 Bennett, Nicholas
Randomized,
Biota Scientific Mgmt
Parallel Dose, Pty Ltd
Phase 1/2 Safety
and
Pharmacokinetics
Study of Inhaled
Laninamivir
Octanoate
TwinCaps® Dry
Powder Inhaler in
Children with
Naturally Acquired
Influenza A or B
1/15/14
12/31/14
$14,095.68 1 of 2
n/a
n/a
180283 Bezler, Natalie
Health Literacy & Hyundai Hope on
Patient Outcomes Wheels
After Bone
Marrow
Transplantation
12/1/14
12/31/14
$75,000.00 1 of 1
n/a
n/a
3/15/14
n/a
n/a n/a
n/a
Borrup, Kevin Road Safety Program
Kohl’s
n/a
179371 Boruchov, Donna
Public Health
“DHHS/CDC/ATHN
Surveillance for (UMASS)”
the Prevention of
Complications of
Bleeding &
Clotting Disorders
9/30/14
12/31/14
$24,471.00 1 of 1
n/a
n/a
179636 Boruchov, Donna
Sickle Cell
CT/DPH
Disease Program
7/1/14
12/31/14
$101,348.00 2 of 3
n/a
n/a
179639 Boruchov, Donna
CT Sickle Cell
Consortium
“CT/DPH (Hosp for
Special Care)”
7/1/14
12/31/14
$19,051.00 1 of 1
n/a
n/a
180265 Boruchov, My Life Our
DonnaFuture
Biogen Idec/ATHN
1/1/14
12/31/14
$3,500.00 1 of 2
n/a
n/a
180274 Boruchov, Data Quality
DonnaCounts
ATHN
7/1/14
12/31/14
$17,500.00 2 of 2
n/a
n/a
81
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180800 Boruchov, Donna
A Phase I/III
CSL Behring, LLC
Open Label,
Multicenter,
Crossover Safety,
Efficacy and
Pharmacokinetic
Study of
Recombinant
Coagulation
Factor VIII (rFVIII)
Compared to
Recombinant
Human
Antihaemophilic
Factor VIII (rFVIII;
INN: octocog alfa)
in Subjects with
Hemophilia A, and
a Repeat PK,
Safety and
Efficacy Study
(Part 3)
1/1/14
12/31/14
$32,852.12 2 of 2
n/a
n/a
180812 Boruchov, Donna
H7T MC TADO Eli Lilly
Phase 3, Doubleblind, Randomized,
Efficacy and
Safety
Comparison of
Prasugrel and
Placebo in
Pediatric Patients
with Sickle Cell
Disease.
1/1/14
12/31/14
$11,410.00 2 of 2
n/a
n/a
180819 Boruchov, Donna
Single-Dose
Bristol Myers Squibb
Study to Evaluate
the
Pharmacokenetics,
Pharmacodynamics,
Safety, and
Tolerability of
Apixaban in
Pediatric Subjects
at Risk for a
Venous or Arterial
Thrombotic
Disorder
1/1/14
12/31/14
$9,250.00 2 of 2
n/a
n/a
180827 Boruchov, Donna
A Phase III Open CSL Behring, LLC
Label, Multicenter,
Extension Study to
Assess the Safety
& Efficacy of
Recombinant
Coagulation
Factor VII
CSL627 in
Subjects with
Severe
Hemophilia A
10/27/14
12/31/14
$100.00 2 of 3
n/a
n/a
1/1/14
n/a
n/a n/a
n/a
n/a
6/1/14
n/a
n/a n/a
n/a
n/a
Brock, Karen Safe Kids Project Epic
Brock, Karen Safe Kids Project Connecticut Elks Association
82
Grants & Contracts
CC#
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
179330 Cloutier, Early Childhood DHHS/NIH/NICHD
MichelleObesity
Prevention:
Building Healthier
Families and
Communities
1/1/14
12/31/14
$194,548.00 2 of 2
UCHC
$37,966.00
179637 Cloutier, DPH - Easy
CT/DPH
MichelleBreathing
Program 2014-15
7/1/14
12/31/14
$250,000.00 2 of 3
UCHC
$6,299.00
180261 Cloutier, Michelle
1/1/14
12/31/14
$380,597.00 1 of 2
UCHC
$94,630.00
7/1/14
6/30/15
n/a 6 of 6
CCMC is prime
$6,299.00
Cloutier, Early Childhood DHHS/NIH
MichelleObesity
Prevention:
Building Healthier
Families and
Communities
4/1/14
3/31/15
n/a 2 of 2
CCMC is prime
$37,966.00
Cloutier, Building Bridges: GSK
MichelleAdvancing
Education by
Improving Asthma
Management in
Inner City Children
1/1/14
12/31/14
n/a 2 of 3
CCMC is prime $59,499.00
180263 Cloutier, Michelle
1/1/14
12/31/14
$179,991.05 1 of 2
n/a
n/a
179256 Demirci, Cem Type 1 Diabetes DHHS/NIH/NIDDK
TrialNet
(Univ South Florida)
7/1/14
12/31/14
$3,165.00 4 of 5
n/a
n/a
180814 DiMario, Francis
1/1/14
12/31/14
$17,535.69 2 of 2
n/a
n/a
179370 Dumont-
Early Detection of “DHHS/NIH (UCONN 9/1/14
Mathieu,Pervasive
Storrs)”
ThydeDevelopmental
Disorders
12/31/14
$10,467.00 1 of 1
n/a
n/a
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Building Bridges: “Glaxo Smith Kline
Advancing (Univ of Colorado)”
Education by
Improving Asthma
Management in
Inner City Children
Cloutier, Easy Breathing
MichelleProgram
DPH
Easy Breathing
CHNCT
Training &
Consulting 13-14
A Three-arm,
Novartis
Randonmized, Pharmaceuticals Corp
Double-blind, Placebo-controlled
Study of the
Efficacy and
Safety of Two
Trough-ranges of
Everolimus as
Adjunctive
Therapy in Patients
with Tuberous
Sclerosis Complex
(TSC) Who Have
Refractory Partialonset Seizures
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
83
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
179638 Dworkin, Regional Care PaulCoordination
Community
Collaborative
CT/DPH
7/1/14
12/31/14
$20,000.00 1 of 3
n/a
n/a
179644 Dworkin, Paul
Maternal Child
Health Blueprint
“CT/DPH (City of
Hartford)”
7/1/14
12/31/14
$10,000.00 1 of 2
n/a
n/a
180271 Dworkin, Paul
Use of a National WK Kellogg Fdn
Affiliate Network
to Diffuse System
Innovation to
Promote
Vulnerable
Children’s Optimal
Healthy
Development
7/1/14
12/31/14
$246,483.00 1 of 3
n/a
n/a
180282 Dworkin, Paul
Meeting the
Lego Children’s Fund
Needs of CT’s
Young Children by
Spreading the
Impact of MidLevel
Developmental
Assessment &
Strengthening the
Help Me Grow
System
9/22/14
12/31/14
$250,000.00 1 of 2
n/a
n/a
Dworkin, Paul
Office for
Berthe M. Cote
Community Child Foundation
Health Educating
Practices in the
Community
6/1/14
n/a
n/a
n/a
n/a
n/a
Dworkin, Paul
Office for
Community Child
Health - New
Britain Healthy
Homes
n/a
n/a
n/a
n/a
n/a
1/1/14
12/31/14
per patient 5 of 6
n/a
n/a
Clinical Accuracy CAS Medical Systems 1/1/14
Evaluation of the
CAS Model 740
Non-Invasive
Blood Pressure
Monitor (Intraarterial Method).
Neonatal/Infant
Study.
12/31/14
$5,300.40 3 of 3
n/a
n/a
Stanley Black & Decker 8/31/14
180758 Edelheit, A Longterm
Abbott Laboratories
BarbaraMulticenter
Longitudinal
Postmarketing
Observational
Registry of Humira
(Adalimumab) in
Children with
Active JIA. Phase
1.
180791 Eisenfeld, Leonard
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
84
Grants & Contracts
CC#
Principal
Award Title
Investigator
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180740 Emerick, Evaluation of the Bristol Myers Squibb
KaranPharmacokinetics,
Safety, Tolerability
and Efficacy of
Entecavir in
Pediatric Subjects
with Chronic
Hepatitis B Virus
Who Are HB3AG
-Positive
1/1/14
12/31/14
$5,107.19 6 of 7
n/a
n/a
180780 Emerick, Karan
A Comparative
Bristol Myers Squibb
Study of the
Antiviral Efficacy
and Safety of
Entecavir (ETV)
versus Placebo in
Pediatric Subjects
with Chronic
Hepatitis B Virus
Infection
1/1/14
12/31/14
$22,770.98 5 of 6
n/a
n/a
179246 Estrada, Elizabeth
Studies to Treat or DHHS/NIH/NIDDK 1/1/14
Prevent Pediatric (George Washington U)
Type 2 Diabetes (George Washington U)
12/31/14
$1,820.00 4 of 5
n/a
n/a
180639 Estrada, Elizabeth
KIGS
180707 Estrada, Tercica Registry
ElizabethAgreement
(MS 305)
Funding Source (Primary/Secondary)
Pfizer, Inc.
1/1/14
12/31/14
$4,433.31 11 of 12
n/a
n/a
Tercica, Inc.
1/1/14
12/31/14
$1,846.07 7 of 8
n/a
n/a
180786 Estrada, Elizabeth
Colesevelam Oral Daiichi Sankyo, Inc.
Suspension as
Monotherapy or
Add-On to
Metformin
Therapy in
Pediatric Subjects
with Type 2
Diabetes Mellitus
1/1/14
12/31/14
$16,465.30 4 of 5
n/a
n/a
179359 Ferrer, Fernando
Sphingosine-1-
Phosphate Pathway Based
Therapy for
Neuroblastoma
7/1/14
12/31/14
$335,040.00 3 of 3
CCMC $68,364.00
n/a
n/a n/a
n/a
Ferrer, Neuroblastoma
FernandoResearch
179358 Finck, Christine
DHHS/NIH/NCI
(UCHC)
The Seraph Foundation 6/1/14
n/a
Optimal Derivation DHHS/NIH/NHLBI
of Murine (UCHC)
Embryonic Distal
Airway Stem Cells
7/1/14
12/31/14
$336,875.00 3 of 3
CCMC $109,159.00
180701 Greenstein, Hunter Outcome Shire Human Genetic
RobertSurvey
Therapies
1/1/14
12/31/14
per patient 7 of 7
n/a
n/a
85
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180779 Hagadorn, James
Phase III, Inhaled INO Therapeutics, LLC 1/1/14
Nitric Oxide for
the Treatment of
Bronchopulmonary
Dysplasia (BPD) in
Pre-term Infants
Requiring
Mechanical
Ventilation or
Positive Pressure
Support on Days
5 - 14 After Birth
12/31/14
$2,250.00 5 of 5
n/a
n/a
180804 Heller, Felice
Adult Congenital Actelion Pharma USA 1/1/14
Heart Disease
Enhancement
Clinical Research
Initiative
12/31/14
$5,250.00 2 of 3
n/a
n/a
180799 Hussain, Naveed
A Phase 3
Astella Pharma Global 1/1/14
Randomized, Development
Double-blind,
Multicenter Study
to Compare the
Efficacy and
Safety of
Micafungin Versus
Amphotericin B
Deoxycholate for
the Treatment of
Neonatal
Candidiasis
12/31/14
$3,760.00 n/a
n/a
179296 Hyams, Jeffrey
Predicting
DHHS/NIH/NIDDK
Response to
Standard Pediatric
Colitis Therapy:
The PROTECT
study
1/1/14
12/31/14
$2,311,223.00 3 of 5
UCHC
$6,671.00
1/1/14
12/31/14
$3,841.87 n/a
n/a
n/a
180725 Hyams, A Multicenter, Janssen Services, LLC 1/1/14
JeffreyProspective,
Long-term,
Observational
Registry of
Pediatric Patients
with Inflammatory
Bowel Disease
12/31/14
$280,683.11 6 of 7
n/a
n/a
180727 Hyams, Jeffrey
12/31/14
$1,483.38 6 of 7
n/a
n/a
180627 Hyams, A Multicenter
Centocor
JeffreyInternational
Observational
Study of the
Long-term Safety
of Infliximab
(Remicade)
Results - UC
Janssen Services, LLC 1/1/14
Long-term - A
Multicenter
International Study
of the Long-term
Safety of Infliximab
(REMICADE) in
Ulcerative Colitis
2 of 3
86
Grants & Contracts
CC#
Principal
Award Title
Investigator
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
Predicting
The Hospital for Sick
Response to Children
Intravenous
Corticosteroid
Therapy in
Pediatric Patients
with Ulcerative
Colitis
1/1/14
12/31/14
$8,727.20 n/a
n/a
n/a
180753 Hyams, Investigative
Elan Pharmaceuticals
JeffreyNatalizumab
Through Further
Observational
Research and
Monitoring Phase
IV Registry
1/1/14
12/31/14
$6,863.40 5 of 6
n/a
n/a
180756 Hyams, Jeffrey
Risk Stratification CCFA (Emory U)
and Identification
of Immunogenetic
and Microbial
Markers of Rapid
Disease
Progression in
Children with
Crohn’s Disease
1/1/14
12/31/14
$21,390.43 5 of 6
n/a
n/a
180765 Hyams, Jeffrey
Phase 2, Open
UCB, Inc.
Label, Multicenter
Study to Assess
the Safety and
Efficacy of
Certolizumab
Pegol in Children
and Adolescents
with Active
Crohn’s Disease
1/1/14
12/31/14
$11,689.80 5 of 6
n/a
n/a
180777 Hyams, Jeffrey
A Multidisciplinary CCFC (Mt. Sinai Hosp) 1/1/14
Human Study on
the Genetic,
Environmental,
and Microbial
Interactions That
Cause IBD
12/31/14
$87,201.79 4 of 10
n/a
n/a
180795 Hyams, Jeffrey
A Phase 1,
Shire Pharmaceuticals, 1/1/14
Multicenter, Open Inc.
Label Study to
Determine the
Safety and
Pharmacokinetics
of MMX
Mesalamine
Following
Administration in
Children and
Adolescents With
Ulcerative Colitis
12/31/14
$8,139.97 2 of 3
n/a
n/a
12/31/14
$20,071.64 2 of 3
n/a
n/a
180750 Hyams, Jeffrey
180808 Hyams, The ImageKids
JeffreyStudy
Funding Source (Primary/Secondary)
Shaare Zekek Medical 1/1/14
Ctr
87
Grants & Contracts
CC#
Principal
Award Title
Investigator
180815 Hyams, Jeffrey
Funding Source (Primary/Secondary)
A Phase 1b Open Janssen Research &
Label Study to Development LLC
Assess the Safety
and
Pharmacokinetics
of Subcutaneously
Administered
Golimumab, a
Human anti-TNFα
Antibody, in
Pediatric Subjects
With Moderately
to Severely Active
Ulcerative Colitis
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
1/1/14
12/31/14
$45,432.94 2 of 3
n/a
n/a
180830 Hyams, Serum - Derived
JeffreyBovine
Immunoglobulin
Entera Health
11/14/14
12/31/14
$25,000.00 1 of 2
n/a
n/a
179356 Isakoff, Michael
National Clinical
Trials Network Grant
“DHHS/NIH/NCI
(CHOP)”
3/1/14
12/31/14
$10,000.00 1 of 1
n/a
n/a
179357 Isakoff, Michael
Per Case
Reimbursement
DHHS/NIH/NCI/
COG (CHOP)
1/1/14
12/31/14
$20,550.00 1 of 2
n/a
n/a
179374 Isakoff, Michael
Study Chair
National Clinical Trials Network
Grant
“DHHS/NIH/NCI
(CHOP)”
4/11/14
12/31/14
$7,500.00 na
na
180213 Isakoff, Michael
multiple studies
COG (CHOP)
1/1/14
12/31/14
$41,500.00 1 of 2
n/a
n/a
180213 Isakoff, Michael
A Dose
Jazz Pharmaceutical/
Confirmation and COG (CHOP)
Pharmacokinetic
Study of Asparec
(pegcrisantaspase)
Administered as
Intravenous (IV)
Infusion in Children
and Young Adults
with Acute
Lymphoblastic
Leukemia (ALL)/
Lymphoblastic
Lymphoma (LBL)
Following
Hypersensitivity to
Pegaspargase
(Oncaspar)
1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
180213 Isakoff, Michael
A Phase II
Millenium
1/1/14
Randomized Trial Pharmaceuticals/COG
for Patients with (CHOP)
de novo AML
Using Bortezomib
(NSC# 681239)
and Sorafenib
(BAY 43-9006,
NSC# 724772)
for Patients with
High Allelic Ratio
FLT2/ITD
12/31/14
pp/private 1 of 2
n/a
n/a
1 of 1
88
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180213 Isakoff, Michael
A Phase II Study Pfizer Inc/COG
of Sunitinib in (CHOP)
Recurrent or
Progressive Brain
Tumors in Pediatric
and Young Adult
Patients
1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
180213 Isakoff, Michael
A Phase 2 Trial of Glaxosmithkline, LLC/ 1/1/14
Pazopanib NSC COG (CHOP
#737754, IND
#65747 in
Children with
Refractory Solid
Tumors
12/31/14
pp/private 1 of 2
n/a
n/a
180213 Isakoff, Michael
Intergroup Trial for Hoffman-La Roche
Children or LTD/COG (CHOP)
Adolescents with
B-Cell NHL or
B-AL: Evaluation
of Rituximab
Efficacy and
Safety in High
Risk Patients
LTD/COG (CHOP)
1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
180213 Isakoff, Michael
A Phase 2
Bristol Myers Squibb/
Multicenter COG (CHOP)
Historically
Controlled Study
of Dasatinib
Added to Standard
Chemotherapy in
Pediatric Patients
with Newly
Diagnosed
Philadelphia
Chromosome
Positive Accute
Lymphoblastic
Leukemia
1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
180250 Isakoff, Michael
multiple studies
Moffitt
1/1/14
12/31/14
$16,399.00 2 of 2
n/a
n/a
180250 Isakoff, Michael
A Phase I Trial of Moffitt Dose Escalation
of Metformin in
Combination with
Vincristine,
Irinotecan, and
Temozolomide in
Children with
Relapsed or
Refractory Solid
Tumors
1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
180250 Isakoff, Michael
Phase I, Traditional Moffitt 3+3, Trial of PO
Sorafenib and
Topotecan in
Refractory or
Recurrent
Pediatric Solid
Malignancies
1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
89
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
Moffitt 1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
180250 Isakoff, Michael
A Phase I Window, Moffitt Dose Escalating
and Safety Trial of
Metformin in
Combination with
Induction
Chemotherapy in
Relapsed
Refractory Acute
Lymphoblastic
Leukemia:
Metformin with
Induction
Chemotherapy of
Vincristine,
Dexamethasone,
Doxorubicin, and
PEG-asparaginase
(VLPD)
1/1/14
12/31/14
pp/private 1 of 2
n/a
n/a
180797 Isakoff, Michael
A Phase II Study COG (CHOP)
of Sunitinab in
Recurrent or
Progressive Brain
Tumors in Pediatric
and Young Adult
Patients
1/1/14
12/31/14
per patient 2 of 2
n/a
n/a
Isakoff, Michael
Hematology/
Oncology Clinical
Trials
6/30/14
n/a
n/a n/a
n/a
n/a
Isakoff, Michael
Hematology/
CureSearch for
Oncology Clinical Children’s Cancer
Trials
1/15/14
n/a
n/a n/a
n/a
n/a
Isakoff, Michael
Adolescent &
Reid R. Sacco AYA
Young Adult (AYA) Cancer Alliance
Cancer Program
1/31/14
n/a
n/a n/a
n/a
n/a
n/a
n/a
n/a
180250 Isakoff, Personalized
MichaelMedicine:
Pediatric Total
Cancer Care
Protocol
AFLAC
Lapidus, Safe Kids GaryWorldwide
Safe Kids Worldwide
9/10/14
n/a
n/a 180262 Lapin, Craig Therapeutic Development Center 2014
Cystic Fibrosis
Therapeutic Fdn
1/1/14
12/31/14
$65,957.00 1 of 1
n/a
n/a
180272 Lapin, Craig CF Center CF Fdn Therapeutics
Support - Nurse &
Nutritionist
7/1/14
12/31/14
$47,035.00 1 of 1
n/a
n/a
180770 Lapin, Craig
1/1/14
12/31/14
$4,500.00 4 of 5
n/a
n/a
Controlled Trial of Novartis
Two Adherence Pharmaceuticals Corp
Promotion (Univ Miami)
Interventions for
Cystic Fibrosis, [I
Change
Adherence and
Raise
Expectations
(ICARE)]
90
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180788 Lapin, Craig
A Phase 3, MPEX
Multicentered, Pharmaceuticals, Inc.
Multinational,
Randomized,
Double-blind,
Placebo-controlled
Study to Evaluate
the Efficacy and
Safety of MP-376
in Stable Cystic
Fibrosis Patients
1/1/14
12/31/14
per patient 3 of 4
n/a
n/a
180789 Lapin, Craig
A Phase 3, Open MPEX
Label, Randomized Pharmaceuticals, Inc.
Trial to Evaluate the Safety and
Efficacy of
MP-376 Inhalation
Solution
(Aeroquin) Versus
Tobramycin
Inhalation Solution
(TIS) in Stable
Cystic Fibrosis
Patients
1/1/14
12/31/14
$6,496.51 3 of 4
n/a
n/a
180796 Lapin, Craig
A Phase 3, Vertex Pharmaceuticals 1/1/14
Randomized,
Double-blind,
Placebo-controlled,
Parallel Group
Study to Evaluate
the Efficacy and
Safety of Ivacaftor
in Subjects with
Cystic Fibrosis
Who Have the
R117H-CFTR
Mutation
12/31/14
$17,057.28 2 of 3
n/a
n/a
180801 Lapin, Craig
A Long-term Seattle Children’s Hosp 1/1/14
Prospective
Observational
Safety Study of
the Incidence of
and Risk Factors
for Fibrosing
Colonopathy in
US patients with
Cystic Fibrosis
Treated with
Pancreatic Enzyme
Replacement
Therapy
12/31/14
$4,025.60 2 of 3
n/a
n/a
91
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180803 Lapin, Craig
A Phase 3, Vertex Pharmaceuticals 1/1/14
Two-arm, Rollover
Study to Evaluate
the Safety of
Long-term
Ivacaftor
Trreatment in
Subjects 6 Years
of Age and Older
with Cystic Fibrosis
and a Non-G551D
CFTR Mutation
12/31/14
$40,237.69 2 of 3
n/a
n/a
180805 Lapin, Craig
An Open Label Hartford Hosp
Study to Assess
the Population
Pharmacokinetics,
Safety, and
Practicality of
Administering
Meropenem as a
Prolonged Infusion
to Cystiic Fibrosis
Children Admitted
With an Acute
Pulmonary
Exacerbation
1/1/14
12/31/14
$27,761.74 2 of 3
n/a
n/a
180811 Lapin, Craig
A Phase 3, Vertex Pharmaceuticals 1/1/14
Randomized,
Double-blind,
PlaceboControlled, Parallel
Group Study to
Evaluate the
Efficacy and
Safety of
Lumacaftor in
Combination with
Ivacaftor in
Subjects Aged
12 Years and
Older With Cystyc
Fibrosis,
Homozygous for
the F508delCFTR Mutation
12/31/14
$11,745.02 2 of 3
n/a
n/a
180816 Lapin, Craig
A Point-Prevalence AbbVie, Inc; Aptalis
Study to Evaluate Pharma, Inc; Janssen
the Prevalence of Research &
Antibodies to Development LLC
Selected Porcine
Viruses in Patients
with Cystic
Fibrosis Who Are
Receiving Porcine
-Derived
Pancreatic Enzyme
Replacement
Therapy: A
Harmonized
Protocol Across
Sponsors
12/31/14
$14,881.00 2 of 3
n/a
n/a
1/1/14
92
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180820 Lapin, Craig
A Phase 3, Vertex Pharmaceuticals 1/1/14
Rollover Study to
Evaluate the
Safety and
Efficacy of Longterm Treatment
With Lumacaftor
in Combination
With Ivacaftor in
Subjects Aged 12
Years and Older
With Cystic
Fibrosis,
Homozygous or
Heterozygous for
the F508delCFTR Mutation
12/31/14
$31,255.55 2 of 3
n/a
n/a
179349 Livingston, Nina
SCAN Pediatrician “DHHS/ACF
- Federal
(CT/DCF)”
7/1/14
12/31/14
$220,500.00 1 of 1
n/a
n/a
179366 Livingston, Nina
SCAN St. Francis “Nat’l Children’s Alliance 8/7/14
Service Agreement (St Francis Hosp)”
12/31/14
$39,600.00 1 of 1
n/a
n/a
179635 Livingston, Nina
SCAN Pediatrician CT/DCF 7/1/14
12/31/14
$241,338.00 1 of 1
n/a
n/a
179645 Livingston, Nina
CAP’s Careline
Support Network
Pilot Program
12/22/14
12/31/14
$52,329.00 1 of 1
n/a
n/a
Livingston, Nina
Direct Services – VOCA - Justice Dept.
Child Abuse
Program
7/1/13
6/30/14
$255,390.00 3 of 3
n/a
n/a
Livingston, Nina
Direct Services – Dept. of Children &
Victims of Abuse Families
7/1/13
6/30/14
$195,140.00 2 of 3
n/a
n/a
Livingston, Nina
Children’s Center Ensworth Foundation
Program Support
1/1/14
12/31/14
$10,000.00 1 of 1
n/a
n/a
7/1/13
6/30/14
$127,100.00 1 of 5
n/a
n/a
Livingston, Child Sexual
NinaAbuse
CT/DCF
CT Dept. of Public
Health
Livingston, Nina
Sexual Abuse
Office of Victim
10/1/13
Exams/Interviews Services - Justice Dept.
9/30/14
$210,458.00 1 of 1
n/a
n/a
Livingston, Nina
Children’s Center National Children’s
Program Support Alliance
12/31/14
$20,000.00 1 of 1
n/a
n/a
Livingston, Child Protection/ The Lane Construction 2/1/14
NinaSCAN Corp.
n/a
n/a n/a
n/a
179343 Makari, John
12/31/14
$10,520.00 2 of 5
n/a
n/a
Short-term Outcomes of Interventions for
Reproductive
Dysfunction
1/1/14
DHHS/NIH/NICHHD 5/1/14
(Univ of Oklahoma)
n/a
93
Grants & Contracts
CC#
Principal
Award Title
Investigator
180798 Makari, John
Funding Source (Primary/Secondary)
A 12-Week, Pfizer, Inc.
Randomized, Open
Label, Active
Comparator Period
Followed by a
12-Week Safety
Extension Period
to Evaluate the
Safety and
Efficacy of
Fesoterodine in
Subjects Ages
6 to 16 Years and
>25 kg w
McGrath, Nursing Research Acorn Alcinda
Jacqueline
Foundation, Inc.
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
1/1/14
12/31/14
$15,500.00 2 of 2
n/a
n/a
3/15/14
Menillo, Lisa Hartford Regional CT Dept. of Public
Lead Treatment Health
Center
7/1/13
6/30/14
$180,286.00 3 of 3
CCMC
$21,438.00
179367 Ohannessian, Adaptive
“DHHS/NIH/NIDA
Christine
Treatment for (UCHC)”
Adolescent
Cannabis Disorder
8/1/14
12/31/14
$21,826.00 1 of 1
n/a
n/a
179368 Ohannessian, Treatment of
“DHHS/NIH/NIDA
Christine
Co-Occuring (UCHC)”
Alcohol Use
Disorder &
Depression/
Anxiety Disorders
8/1/14
12/31/14
$7,275.00 1 of 1
n/a
n/a
179319 Orsey, Andrea SunCoast CCOP DHHS/NIH/NCI
Research Base at (Univ South Florida)
the University of
South Florida
1/1/14
12/31/14
$10,000.00 1 of 2
n/a
n/a
180273 Orsey, Andrea Pilot Yoga “UCONN Storrs
Intervention - (UCHC)”
Peds Cancer
Patients Sleep &
Life Quality and
Parents Well Being
7/1/14
12/31/14
$13,483.00 1 of 1
n/a
n/a
180792 Orsey, Andrea An Open-Label, Purdue Pharma LP
Multicenter Study
of the Safety of
Twice Daily
Oxycodone
Hydrochloride
Controlled-release
Tablets in Opioid
Experienced
Children from
Ages 6 to 16
Years Old
1/1/14
12/31/14
$144,909.41 3 of 4 n/a
n/a
180206 Parikh, Nehal
1/1/14
12/31/14
$41,000.00 4 of 5
n/a
n/a
Neuroblastoma and
Medulloblastoma
Translational
Research
Consortium
Van Andell Institute
94
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180206 Parikh, Nehal
Molecular Analysis Neuroblastoma and
1/1/14
of Pediatric Tumors Medulloblastom
with Establishment Translational Research
of Tumor Models in Consortium (Spectrum
a Biology Study Health)
12/31/14
pp/private 5 of 6
n/a
n/a
180206 Parikh, Nehal
A Feasibility Trial Using Molecular-
Guided Therapy for
the Treatment of Patients with Refractory or
Recurrent
Neuroblastoma
Neuroblastoma and
1/1/14
Medulloblastoma
Translational Research
Consortium (Spectrum
Health)
12/31/14
pp/private 5 of 6
n/a
n/a
180206 Parikh, Nehal
A Phase I Trial for Neuroblastoma and
1/1/14
Refractory or Medulloblastom
Relapsed Translational Research
Neuroblastoma Consortium (Spectrum
with DFMO Alone Health)
and in Combination
with Etoposide
12/31/14
pp/private 5 of 6
n/a
n/a
180206 Parikh, Nehal
A Feasibility Trial Neuroblastoma and
1/1/14
Using Molecular- Medulloblastoma
Guided Therapy for Translational Research
the Treatment of Consortium (Spectrum
Patients with Health)
Relapsed and
Refractory
Childhood Cancer
12/31/14
pp/private 5 of 6
n/a
n/a
180206 Parikh, Nehal
A Phase II Neuroblastoma and
1/1/14
Preventative Trial Medulloblastom
of DFMO as a Translational Research
Single Agent in Consortium (Spectrum
Patients with High Health)
Risk
Neuroblastoma in
Remission
12/31/14
pp/private 5 of 6
n/a
n/a
180206 Parikh, Nehal
A Phase I/II Trial of TPI 287 in Patients with Refractory or Recurrent Neuroblastoma or
Medulloblastoma
Neuroblastoma and
1/1/14
Medulloblastom
Translational Research
Consortium (Spectrum
Health)
12/31/14
pp/private 5 of 6
n/a
n/a
180206 Parikh, Nehal
A Phase I/II Trial of Irinotecan and Temozolomide Compared to Ininotecan and Temozolomide in
Combination with
TPI 287 in Patients
with Refractory or
Early Relapsed
Neuroblastoma
Neuroblastoma and
1/1/14
Medulloblastom
Translational Research
Consortium (Spectrum
Health)
12/31/14
pp/private 5 of 6
n/a
n/a
95
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180206 Parikh, Nehal
Molecular-guided Therapy for the Treatment of Patients with Relapsed and Refractory
Childhood Cancers
Neuroblastoma and
1/1/14
Medulloblastoma
Translational Research
Consortium (Spectrum
Health)
12/31/14
pp/private 5 of 6
n/a
n/a
180206 Parikh, Nehal
A Phase I/II Trial of DFMO in Combination with Bortezomib in Patients with Relapsed or
Refractory
Neuroblastoma
Neuroblastoma an
1/1/14
Medulloblastoma
Translational Research
Consortium (Spectrum
Health)
12/31/14
pp/private 5 of 6
n/a
n/a
180224 Parikh, Nehal
Clinical Trial of Dell (Van Andell
Molecular-GuidedInstitute)
Therapy for the
Treatment of
Patients with
Refractory or
Recurrent
Neuroblastoma
1/1/14
12/31/14
$25,000.00 3 of 3
n/a
n/a
180281 Parikh, Nehal
Advanced Therapeutics
Program
Infrastructure
10/1/14
12/31/14
$50,000.00 1 of 1
n/a
n/a
180728 Parikh, Nehal
A Multi-Center, Grifols
Prospective, Open
Label, Clinical Trial
to Assess the
Safety and
Efficacy of a New
Intravenous
Immune Globulin
(IGIV31 Grifols
10%) in Patients
with Idiopathic
(Immune)
Thrombocytopenic
Purpura
1/1/14
12/31/14
$107.00 6 of 7
n/a
n/a
DHHS/OS (CT/DPH) 7/1/14
12/31/14
$20,000.00 2 of 3
n/a
n/a
1/1/14
12/31/14
$14,454.58 10 of 11
n/a
n/a
1/1/14
12/31/14
$28,925.66 1 of 1
n/a
n/a
179353 Parker, Public Health JamesPreparation
2014-2015
180650 Ratzan, Susan
St Baldricks Fdn
An Observational Nordotropin
Study (Registry)
Assessing
Treatment
Outcomes and
Safety for Children
and Adults Who
Are Prescribed
Norditropin
(Human Growth
Hormone)
180645 Rosengren, RKIGS
Sally
Pharmacia
96
Grants & Contracts
CC#
Principal
Award Title
Investigator
180631 Rubin, Karen
Funding Source (Primary/Secondary)
The Genetics and Eli Lilly
Neuroendocrinology
of Short Stature
International Study
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
1/1/14
12/31/14
$2,036.00 n/a
n/a
180717 Rubin, Karen Girls Turner Syndrome
Eli Lilly
1/1/14
12/31/14
$6,099.31 7 of 12
n/a
n/a
179347 Salazar, Juan Ryan White A 2014-2015
“DHHS/HRSA/City of 3/1/14
Hartford (UCHC)”
12/31/14
$119,066.00 1 of 1
CCMC $52,632.00
DPH
4/1/14
3/31/15
$90,000.00 4 of 6
X
X
179363 Salazar, Juan Ryan White D “DHHS/HRSA
2014-2015(UCHC)”
8/1/14
12/31/14
$331,902.00 1 of 1
CCMC $16,962.00
179364 Salazar, Juan
7/1/14
12/31/15
$36,372.00 1 of 1
n/a
n/a
1/1/14
12/31/14
$128,335.00 2 of 4
X
X
Salazar, Juan Ryan White B
Mechanism of DHHS/NIH/NIAID
Impaired (UCHC)
Mycobacteria
Sensing by TLR2
& TLR4
Polymorphic
Variants
Salazar, Juan CT DPH HIV DPH
Prevention
Interventions 2012
Salazar, Juan
Hartford Teenage DHHS/City of Hartford 10/1/14
Pregnancy
Prevention Initative
(HTPPI)
9/30/15
$24,700.00 3 of 3
X
X
180270 Salazar, Olga
ARC - Use of Diversity Outbred
Mice to Study
Cardiotoxicity of
Chemo
3/1/14
12/31/14
$8,474.00 1 of 2
n/a
n/a
180292 Salazar, Olga
The Role of Maximillian Hoffman
Aerobic Exercise Fdn
to Modulate
Cardiotoxicity in
Long-Term Cancer
Survivors
12/16/14
12/31/14
$50,000.00 1 of 2
n/a
n/a
180267 Sanders, Statewide Quality March of Dimes
MarilynImprovement
Collaborative
5/1/14
12/31/14
$5,000.00 1 of 1
n/a
n/a
180280 Sanders, Statewide
March of Dimes
MarilynNeonatal/Perinatal
Quality
Improvement
Collaborative
10/1/14
12/31/14
$10,000.00 1 of 1
n/a
n/a
12/31/14
$35,367.00 1 of 3
n/a
n/a
Jackson Labs
180268 Santos, CICATS Pain & CT Institute for Clinical 7/1/14
Melissa
Weight Treatment & Translational Science
(CICATS)
97
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
180824 Schoem, A Prospective,
Otonomy, Inc
ScottRandomized,
Double-blind,
Sham-controlled,
Multicenter, Phase
3 Study of
OTO-201 Given
as a Single
Intratympanic
Injection for Intra
operative
Treatment of
Middle Ear
Effusion in
Pediatric Patients
Requiring
Tympanostomy
Tube Replacement
1/16/14
12/31/14
$81,881.96 1 of 2
n/a
n/a
179375 Silva, Cynthia Pediatric “DHHS/NIH/NIAID
Glomerula (Nationwide Children’s
BiomarkersHospital)”
6/1/14
12/31/14
$9,705.00 1 of 1
n/a
n/a
179355 Skinner, Dental Clinic
DHHS/HRSA (UCHC) 7/1/14
RichardHRSA
Postdoctoral
Training in General,
Pediatrc and Public
Health Dentistry
and Dental
Hygiene 14-15
12/31/14
$48,997.00 1 of 1
n/a
n/a
179640 Slivka, Hilda Childhood Lead CT/DPH
Poisoning Program
9/1/14
12/31/14
$180,286.00 1 of 1
n/a
n/a
Sylvester, Francisco
Predicting
NIH
Response to
Standard Pediatric
Colitis Therapy:
The PROTECT
study 5/1/14
4/30/15
CCMC is prime
$6,671.00
Sylvester, Francisco
Intestinal Gamma NIH/Oregon Health & 7/1/13
-Delta T Cell Science University
Mucosal Responses
in Human Crohn
Disease (MIST)
CCMC $40,388.00
6/30/15
Year# of # of
Award Years
3 of 5
$174,253.00 NCE
Subcontract to Amount of
UCHC/CCMC? Subcontract
98
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
1/1/14
12/31/14
$7,376.96 2 of 3
n/a
n/a
Patient Centered
1/1/14
Outcomes Research
Inst/Children’s Hospital
of Philadelphia
12/31/14
$3,066.00 n/a
n/a
12/31/14
per patient 3 of 4
n/a
n/a
180810 Valdez, Tulio
A Multicenter, Salvat
Randomized,
Double-blind
Clinical Trial to
Assess the
Efficacy and
Safety of
Ciprofloxacin 0.3%
plus Fluocinolone
Acetonide 0.025%
Otic Solution
Compared to
Ciprofloxacin 0.3%
Otic Otic Solution
and to Fluocinolone
Acetonide 0.025%
Otic Solution in the
Treatment of Acute
Otisis Media with
Tympanostomy
Tubes (AOMT) in
Pediatric Patients
180822 Waynik, Ilana
Pediatric Intravenous Versus Oral Antibiotic Theory
(PIVVOT)
180826 Weiss, Richard
Hirschsprung
Johns Hopkins U
Disease Research
Collaborative
(HDRC Study)
Yordan, Elaine
Adolescent
Medical and Mental Health
State of CT – Judicial 7/1/13
Branch, Broad Street
6/30/14
$467,000.00 4
n/a
n/a
Yordan, Elaine
Adolescent
Medical and Mental Health
State of CT - Judicial
Branch - Washington
Street & Grace/CRP
6/30/14
$220,000.00 4
n/a
n/a
180251 Zemel, Lawrence
CARRA Registry Arthritis Fdn (Duke U) 1/1/14
12/31/14
per patient 1 of 2
n/a
n/a
180742 Zemel, A 12-Week
Roche Laboratories, Inc. 1/1/14
LawrenceRandomized,
Double-blind,
Placebo
controlled, Parallel
Group, Two-Arm
Study to Evaluate
the Efficacy and
Safety of
Tocilizumab in
Patients with
Active Juvenile
Idiopathic Arthritis:
with 92-Week
Single Arm Open
Label Extension to
Examine the
Long-term Use of
Tocilizumab
12/31/14
$47,050.32 5 of 6
n/a
n/a
7/16/14
7/1/13
99
Grants & Contracts
CC#
Principal
Award Title
Investigator
Funding Source (Primary/Secondary)
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
180794 Zemel, Lawrence
Phase 3, Multi-
UCB, Inc.
center, Open
Label Study to
Assess the
Pharmacokinetics,
Safety and
Efficacy of
Certolizumab
Pegol in Children
and Adolescents
with Moderately to
Severely Active
PolyarticularCourse Juvenile
Idiopathic Arthritis
1/1/14
12/31/14
$27,968.10 1 of 2
n/a
n/a
180813 Zemel, Lawrence
A Phase 3 Bristol-Meyers Squibb 1/1/14
Multicenter, Open
Label Study to
Evaluate
Pharmacokinetics,
Efficacy and
Safety of
Abatacept
Administered
Subcutaneously
(SC) in Children
and Adolescents
with Active
Polyarticular
Juvenile Idiopathic
Arthritis (pJIA)
and Inadequate
Response (IR) to
biologic or non
biologic Disease
Modifying Antirheumatic Drugs
(DMARDs)
12/31/14
$28,560.76 1 of 2
n/a
n/a
180817 Zemel, Lawrence
An Phase Ib Open Genentech
Label Multicenter
Study to
Investigate
Pharmacokinetics,
Pharmacodynamics,
and Safety of
Tocilizumab
Following
Subcutaneous
Administration in
Patients with
PolyarticularCourse Juvenile
Idiopathic Arthritis
12/31/14
$10,750.00 1 of 2
n/a
n/a
1/1/14
100
Grants & Contracts
CC#
Principal
Award Title
Investigator
Start Date of
Reported Award
End Date of
Reported Award
Amount of
Total Award
1/1/14
12/31/14
$11,663.84 1 of 2
n/a
n/a
180264 Zempsky, SCD Pain Control Donaghue Fdn
WilliamWeb-based
Educational
Initiative
3/1/14
12/31/14
$55,000.00 1 of 2
n/a
n/a
180275 Zempsky, William
Inpatient Massage Long Fdn
Therapy Program
5/12/14
12/31/14
$7,500.00 1 of 1
n/a
n/a
180802 Zempsky, William
An Open Label
Purdue Pharma, LP
Multicenter Study
of the Safety,
Pharmacokinetics,
and Efficacy of
Buprenorphine
Transdermal
System (BTDS)
Opiod Analgesia
for Moderate to
Severe Pain
1/1/14
12/31/14
$6,250.00 1 of 2
n/a
n/a
180818 Zemel, Lawrence
Funding Source (Primary/Secondary)
A Phase Ib Open Genentech
Label Multicenter
Study to Investigate
Pharmacokinetics,
Pharmacodynamics,
and Safety of
Tocilizumab
Following
Subcutaneous
Administration in
Patients with
Systemic Juvenile
Idiopathic Arthritis
Year# of # of
Award Years
Subcontract to Amount of
UCHC/CCMC? Subcontract
Connecticut Children’s Medical Center is a nationally recognized, 187-bed not-for-profit children’s hospital serving as
the primary teaching hospital for the Department of Pediatrics at the University of Connecticut School of Medicine.
Named among the best in the nation in the annual U.S. News & World Report “Best Children’s Hospitals” rankings,
Connecticut Children’s is the only free-standing children’s hospital in Connecticut that offers comprehensive,
world-class health care to children. Our pediatric services are available at Connecticut Children’s Medical Center in
Hartford and at Saint Mary’s Hospital in Waterbury, with neonatal intensive care units at Hartford Hospital and the
University of Connecticut Health Center, along with a state-of-the-art ambulatory surgery center, five specialty care
centers and 11 other locations across the state. Connecticut Children’s has a medical staff of
nearly 1,100 practicing in more than 30 specialties.
For more information, visit
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