XXXII Winter School on Proteinases and Their Inhibitors Tiers am

XXXIInd Winter School
on
Proteinases and Their Inhibitors
Tiers am Rosengarten
February 25 – March 1, 2015
We thank Shirley Knauer for her contribution to the cover picture. It shows the bright-field microscopy
image of HeLa tumor cells overlaid with the respective fluorescence microscopy image of overexpressed
exogenous human Taspase1 (colored in dark blue), located in nucleoli within the nucleus (stained in light
blue). The colors of the bright-field image were altered. The right circular inset depicts the crystal structure
surface of active Taspase1 (PDB ID: 2a8j) with its two subunits colored in blue and green. The active site
(red patch) is targeted by a peptidyl-succinimidyl peptide (left circular insert), displayed as sticks with a
semitransparent surface (orange). The picture thus illustrates our efforts to design a substrate analogue
inhibitor of the putative cancer target Taspase1, a threonine protease that is frequently overexpressed in
many different leukemias or Taspase1-dependent solid tumors.
32nd Winter School on Proteinases and Their Inhibitors
in Tiers (Italy)
February 25 – March 1, 2015
Organizing Committee
Klaudia Brix (Bremen)
Christian Sommerhoff (Munich)
Boris Turk (Ljubljana)
Hans Brandstetter (Salzburg)
Editors
Michaela Lassacher & Hans Brandstetter
Dept. Molecular Biology
University of Salzburg
Supported by
• Novo Nordisk
• Stricker Laborhandel
•
University of Salzburg (Priority Program)
GENERAL INSTRUCTIONS
Accommodation
All Winterschool participants are accommodated in one of the three hotels Rose, Paradies or Vajolet, all of
which are in five minutes walking distance. If you are unsure, please ask at the registration of Hotel
Paradies. They have a list of all participants and are happy to help you.
While accommodation and meals including mineral water are covered, any extras are not:
•
•
•
Please pay all drinks (except mineral water) directly after the meal.
Please do not forget to pay your good night-drinks before you leave for sleeping.
Please do not forget to pay all your extras (personal orders, …) at your hotel before
departure.
If you want to rent ski equipment, please ask at the Hotel Paradies.
Scientific sessions
All lectures will take place at the Haus der Dorfgemeinde (City Hall).
Social events
•
•
•
•
Thursday evening, City Hall:
Friday evening, Paradies:
Saturday afternoon
Saturday evening, Castle Prösels
Night session with the InhibiTiers Allstar Band
Meet and Make Friends in Proteolysis Research
Several hiking tours, excursions
Gala Dinner & Farewell
Disclaimer
To enable and foster the unrestrained presentation and discussion of new results and ongoing research, every
Winter School attendee must respect that all contents presented and discussed at the Winter School are
private communications, not allowed for public use. Consequently, recording of lectures or
photographing/copying of slides or presentations is prohibited.
PROGRAM
Regular talks are 8 min lecture plus 4 min discussion.
WEDNESDAY, FEBRUARY 25
18:00
Dinner
20:00 – 22:00 Wednesday evening session: Pathogen-derived proteases
20:00 – 20:05
Opening
20:05 – 20:15 Chairs: Esther SCHÖNAUER & Nathalie BEAUFORT: Press release-type introduction
into the session: Background, important questions, challenges, solution strategies
20:15 – 20:27 Carmen ABFALTER (University of Salzburg) The role of the serine protease HtrA in the
pathogenicity of Gram-positive human gastrointestinal pathogens
20:27 – 20:39 Ewa BIELECKA (Jagiellonian University, Krakow) Cooperation between arginine specific
proteases and PPAD from Porphyromonas gingivalis in generation of controlled state of
inflammation in gums during infection
20:39 – 20:51 Przemyslaw GOLIK (Jagiellonian University, Krakow) Lit protease – an altruistic suicide
factor in bacteria.
20:51 – 21:00 Katarzyna KUŚKA (Jagiellonian University, Krakow) Characterization of YaT cysteine
protease from Caldanaerobacter subterraneus
21:00 – 21:12 Christine LEHMANN (MRC London) P. falciparum DPAP3 is a multifunctional cysteine
protease involved in schizont segmentation and erythrocyte invasion.
21:12 – 21:24 Yesid A. RAMIREZ (University of Würzburg) Structural Secrets of ChlaDub1 from
Chlamydia trachomatis
21:24 – 21:36 Marie-Theres VIELBERG (Technical University of Munich) Crystallographic analysis of
the ClpP1/2 heterocomplex from Listeria monocytogenes
21:36 – 21:48 Rudolf WACHTEL (Technical University of Munich) Biochemical Characterization of the
Rab Protease GtgE from Salmonella Typhimurium
21:48 – 22:00 Magdalena SCHACHERL (University of Cologne) Structural basis of proline-proline
peptide bond specificity of a secreted protease implicated in motility of Clostridium difficile
THURSDAY, FEBRUARY 26
09:00 – 10:34 Thursday morning session I: Immunity & Signaling
09:00 – 09:10 Chairs: Linda TROEBERG & Brice KORKMAZ: Press release-type introduction into the
session: Background, important questions, challenges, solution strategies
09:10 – 09:22 Pernille SØGAARD (University of Oxford) DDR1 plays a role in spatial regulation of
MT1-MMP activity during epithelial tubulogenesis
09:22 – 09:34 Neele SCHUMACHER (University of Kiel) ADAM-mediated proteolysis and IL-6 transsignaling in acute inflammation
09:34 – 09:46 Kristin SCHUBERT (University of Oxford) LRP-1 mediated endocytosis of TIMP-3 controls
inflammatory response in human macrophages
09:46 – 09:58 Haissi CUI (Technical University of Munich) Exosomes derived from a TIMP-1conditioned, pre-metastatic liver are rich in Arginase-1 and sufficient to increase liver
metastasis
09:58 – 10:10 Nežka KAVČIČ (Jožef Stefan Institute, Ljubljana) The effect of various antioxidants in cell
death-related oxidative stress
10:10 – 10:22 Steffen RIETHMÜLLER (University of Kiel) Molecular analysis of the human Interleukin6 receptor
10:22 – 10:34 Carla GUARINO (INSERM, Tours) Immune activation of neutrophils by antiPR3 mAbs is
mediated by altered activity of membrane-bound proteinase 3
10:34 – 11:00 COFFEE BREAK
11:00 – 12:30 Thursday morning session II: Technology Meets Function
11:00 – 11:10 Chairs: Christian SOMMERHOFF & Martin RENATUS: Press release-type introduction
into the session: Background, important questions, challenges, solution strategies
11:10 – 11:22 Caroline HOPPE (Jacobs University Bremen) Visualization of tissue kallikrein 7 in human
keratinocytes
11:22 – 11:34 Eileen KROLL (Jacobs University Bremen) Visualization of kallikrein 2 and 3 upon TSH
stimulation in thyroid epithelial cells
11:34 – 11:46 Anna KEPPNER (University of Lausanne) The channel activating protease CAP2/Tmprss4
is not required for ENaC-mediated sodium homeostasis in vivo.
11:46 – 11:58 Maresa GRUNDHUBER (Ludwig-Maximilians-University of Munich) Generation of
proteins and antibodies to study human mast cell tryptases
11:58 – 12:10 Aleksandra PECAK (Jagellonian University Krakow) Production of tissue kallikrein family
proteases in novel expression system LEXSY
12:10 – 12:20 Han FANG (University of Salzburg) Human blood coagulation Factor VIII A2 domain
expression, purification and interaction studies
12:45
LUNCH (Paradies, Rose)
THURSDAY AFTERNOON SESSIONS: CANCER BIOLOGY
14:30 – 15:46 Thursday afternoon session I: Cancer biology
14:30 – 14:40 Chairs: Thomas REINHECKEL & Christoph PETERS: Press release-type introduction into
the session: Background, important questions, challenges, solution strategies
14:40 – 14:52 Stefanie SCHMIDT (University of Kiel) Role of ADAM17 in the development of colon
cancer
14:52 – 15:04 Jeanette SCHWARZ (University of Kiel) Polo-like kinase 2: A novel Regulator of ADAM17
Activity.
15:04 – 15:19 Dirk SCHMIDT-ARRAS (University of Kiel) A disintegrin and metalloprotease (ADAM) 17
in the metastatic niche is crucial for metastasis to the lung.
15:19 – 15:34 Björn RABE (University of Kiel) Senescence-associated release of transmembrane proteins
involves proteolytic processing by ADAM17 and microvesicle shedding
15:34 – 15:46 Barbara GRÜNWALD (Technische Universität München) Hepatic Stellate Cells (HSCs)
activated by TIMP-1/CD63/PI3K signalling express increased levels of metastasis-promoting
genes.
15:46 – 16:15 COFFEE BREAK
16:15 – 17:30 Thursday afternoon session II: Cancer biology
Chairs: Achim KRUEGER & Klaudia BRIX
16:15 – 16:27 Roberta BURDEN (Queen's University Belfast) Cathepsin S mediated regulation of the
tumour microenvironment is in part facilitated by the transcriptional regulation of CCL2
16:27 – 16:39 Richard WILKINSON (Queen's University Belfast) Reversible cathepsin S inhibitor I6
inhibits tumour growth and progression in vitro and in vivo
16:39 – 16:51 Janja ZAVRŠNIK (Jožef Stefan Institute, Ljubljana) The role of cystatin C depletion in
mouse mammary tumor progression and metastasis
16:51 – 17:03 Alejandro GOMEZ-AULI (University of Freiburg) Lysosomal cathepsins regulate the
abundance of Cellular Repressor of E1A stimulated Genes 1
17:03 – 17:15 Sarah Marie BRAUN (University of Freiburg) Differential protease regulation as one
hallmark of murine breast cancer stem cell plasticity
17:15 – 17:27 Ping WANG (Technische Universität München) OV-MZ-6 ovarian cancer cells
overexpressing kallikrein-related peptidases 4, 5, 6 and 7 (KLK4-7): effects on mRNA
expression of cancer-related genes
18:00
DINNER (PARADIES, ROSE)
20:00 – 23:45 NIGHT SESSION (CITY HALL)
FRIDAY, FEBRUARY 27
09:00 – 10:40 Friday morning session I: Meprin & Neurodegeneration
09:00 – 09:10 Chairs: Christoph BECKER-PAULY & Walter STÖCKER: Press release-type introduction
into the session: Background, important questions, challenges, solution strategies
09:10 – 09:22 Valentina BIASIN (Ludwig Boltzmann Institute for Lung Vascular Research, Graz) Role of
meprin β in lung fibrosis
09:22 – 09:34 Johannes PROX (University of Kiel) Ectodomain shedding of CD99 by the metalloprotease
meprin β, implicating a function in leukocyte transmigration
09:34 – 09:43 Felix JÄCKLE (University of Kiel) Activity of membrane bound metalloprotease Meprin β
is regulated by matriptase 2
09:43 – 09:55 Stephan SCHILLING (Fraunhofer Institute for Cell Therapy and Immunology, Halle/Saale)
Heterologous expression of human Meprin β, an alternative β-site cleaving enzyme of APP,
in Pichia pastoris
09:55 – 10:07 Frederike SCHMIDT (University of Kiel) Tetraspanin 8 attenuates meprin β activity thereby
decreasing amyloid β generation
10:07 – 10:16 Anett KETSCHER (University of Freiburg) A novel conditional mouse model to study
tissue-specific functions of Cathepsin D in vivo
10:16 – 10:28 Friederike ZUNKE (University of Kiel) LIMP-2 expression is critical for proteolytic αsynuclein clearance
10:28 – 10:40 Timon LANDINGER (Ludwig-Maximilians-University Munich) Contractile cell plasticity
in HtrA1 protease-related cerebral small vessel disease
10:40 – 11:10 COFFEE BREAK
11:10 – 13:00 Friday morning session II: ADAMs & Metalloproteases
11:10 – 11:20 Chairs: Yoshi ITOH & Ed STURROCK: Press release-type introduction into the session:
Background, important questions, challenges, solution strategies
11:20 – 11:32 Pascal SCHLAGE (ETH Zurich) Monitoring matrix metalloproteinase 10 activity at the
epidermal-dermal junction by SILAC-iTRAQ-TAILS
11:32 – 11:44 Miryam MÜLLER (University of Kiel) A disintegrin and metalloprotease 10 (ADAM10) is
a central regulator of murine liver tissue homeostasis.
11:44 – 11:56 Silvio WEBER (Technische Universität Dresden) Cardiomyocyte-specific loss of A
Disintegrin And Metalloprotease 10 (ADAM10) leads to functional impairment of the murine
heart
11:56 – 12:08 Sebastian WETZEL (University of Kiel) The metalloprotease ADAM10 is an essential
driver of podocyte damage
12:08 – 12:20 Chun-Yao YANG (University of Oxford) Charactering Enzyme Kinetics of ADAM15- a
Novel Chondroprotective Metalloproteinase in Osteoarthritis.
12:20 – 12:29 Philipp ARNOLD (University of Kiel) Meprin β acts as a sheddase of β1-Integrin thereby
inducing intracellular signaling
12:29 – 12:41 Rielana WICHERT (University of Kiel) Meprin β regulates shedding of ADAM10 via
activation of ADAM9
13:00
LUNCH (Paradies, Rose)
FRIDAY AFTERNOON SESSIONS: SUBSTRATES & ENZYME MECHANISMS
14:30 – 16:00 Friday afternoon session I: Substrates
14:30 – 14:40 Chairs: Pitter HUESGEN & Ulrich AUF DEM KELLER: Press release-type introduction
into the session: Background, important questions, challenges, solution strategies
14:40 – 14:52 Fabian E. EGLI (ETH Zurich) ProteasePredictor: assigning proteases to experimentally
derived cleavage sites.
14:52 – 15:04 Fabio SABINO (ETH Zurich) Wound fluid degradomics: system-level insight into protease
dynamics in cutaneous wound healing
15:04 – 15:16 Melanie FÖLL (University of Freiburg) Lighting up the darkness behind Prostasin.
15:16 – 15:23 Angelina HAHLBROCK (University Medical Center of Mainz) (High-throughput) cell
based assays to profile protease’s activity and chemical modulators
15:23 – 15:35 Wioletta RUT (Wroclaw University of Technology) Hybrid combinatorial libraries as a tool
for optimizing the substrate specificity of human proteasome
15:35 – 15:47 Marcin POREBA (Wroclaw University of Technology) HyCoSuL approach for the
optimization of cathepsin L substrate specificity
15:47 – 16:02 Ruth GEISS-FRIEDLANDER (University of Goettingen) Studying the DPP9 interactome
16:02 – 16:30 COFFEE BREAK
16:30 – 18:05 Friday afternoon session II: Substrates & Enzyme Mechanisms
16:30 – 16:40 Chairs: James WHISSTOCK & Guy SALVESEN: Press release-type introduction into the
session: Background, important questions, challenges, solution strategies
16:40 – 16:52 Désirée WÜNSCH (University Medical Center of Mainz) Threonine Aspartase1’s
evolutionary maturation – lessons learned?
17:52 – 17:04 Birgit WALDNER (University of Innsbruck) Molecular Mechanisms of fXa Substrate
Recognition
17:04 – 17:16 Regina FREIER (University of Salzburg) Recognition of birch pollen allergen Bet v 1 by
endolysosomal proteases
17:16 – 17:28 Matthias FELTEN (University of Mainz) Functional Characterization of Ovastacin
17:28 – 17:40 Elfriede DALL (University of Salzburg) One enzyme - 2 functions: a refined view on the
legumain active site.
17:40 – 17:50 Florian ZAUNER (University of Salzburg) Biochemical characterization of plant legumains
17:50 – 18:05 Gondichatnahalli M. LINGARAJU (Friedrich Miescher Institute & Novartis) Crystal
structure of the human COP9 signalosome
18:30
DINNER (PARADIES, ROSE)
20:00 – 23:00 MEETING AND MAKING FRIENDS IN PROTEOLYSIS RESEARCH (PARADIES)
SATURDAY, FEBRUARY 28
09:00 – 10:37 Saturday morning session I: Inhibition strategies
09:00 – 09:10 Chairs: Line HYLTOFT KRISTENSEN & Chris SCOTT: Press release-type introduction
into the session: Background, important questions, challenges, solution strategies
09:10 – 09:22 Hauke BUSCH & Melanie BÖRRIES (University of Freiburg) Protease and Protease
Inhibitors are Tightly Controlled Through Transcriptional Co-regulation
09:22 – 09:34 Jessica GÖTZFRIED (Helmholtz Zentrum München) Tissue distribution and function of the
putative serine protease inhibitor SERPINA2 and its modifying impact on lung diseases
09:34 – 09:46 Therese DAU (Helmholtz Zentrum München) Measurement of active antitrypsin
concentration in plasma
09:46 – 09:58 Lisa HINKOFER (Helmholtz Zentrum München) Rezymogenation of PR3 induced by
inhibitory mouse and human antibodies
09:58 – 10:10 Sven DAHMS (Leibniz Institute for Age Research, Jena) The structure of apo-furin at 1.8 Å
resolution reveals competitive and allosteric inhibitor mechanisms.
10:10 – 10:22 Christian DUBIELLA (Technische Universität München) Selective Inhibition of the
Immunoproteasome by Ligand-Induced Crosslinking of the Active Site
10:22 – 10:37 Shirley KNAUER (University of Duisburg-Essen) Targeting of Threonine Aspartase1 by
Peptidic Inhibitors
10:37 – 11:10 COFFEE BREAK
11:10 – 12:00 Saturday morning session II: Inhibition strategies
Chairs: Manfred SCHMITT & Oliver SCHILLING
11:10 – 11:22 Lovro KRAMER (Jožef Stefan Institute, Ljubljana) Characterization of potent cathepsin B
inhibitors selected from DARPin libraries
11:22 – 11:34 Mario OLF (Johannes Gutenberg-University Mainz) Nephrosin and Fetuin: An Astacin
Metalloprotease and its Endogenous Inhibitor
11:34 – 11:46 Christine DOHERTY (University of Oxford) Design of a TIMP-3 mutant with an increased
half-life for improved protection against cartilage breakdown
11:46 – 12:00 Roland H. STAUBER (University Medical Center of Mainz) Hit once – better hit twice: An
anti-tumoral natural compound with dual activity as a deubiquitinase- and nuclear exportinhibitor
12:15
LUNCH
SATURDAY AFTERNOON: HIKING, EXCURSION, ROUND TABLE DISCUSSIONS
12:15 – 17:00
“Extreme” hiking tour, guided by Thomas REINHECKEL (lunch package will
be provided)*
13:00 – 17:00
Relaxed hiking tour, guided by Hans FRITZ*
12:15 – 17:00
Locally organized skiing tours (ski equipment can be rent at the Hotel Paradies;
lunch package will be provided)
13:30 – 17:00
Bus tour to Bozen (Visit Ötzi & more)*
*
Sign up for the hiking tours and excursion at the administration desk in the lecture hall.
The meeting point for the excursions is in front of the hotel Paradies.
19:00
GALA DINNER AT CASTLE PRÖSELS
Bus departure time/place will be announced
SUNDAY, MARCH 1
10:00
Bus departure
ABSTRACTS
Available in the printed program only.
LIST OF PARTICIPANTS
THE WINTER SCHOOL FACEBOOK
.
The Winterschool Facebook
Carmen ABFALTER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7212
Valentina BIASIN
Ludwig Boltzmann Institute for
Lung Vascular Research
Stiftingtalstrasse 24
A-8010 Graz
Austria
[email protected]
 +43 0316 385 72897
Philipp ARNOLD
University of Kiel
Anatomical Institute
Otto-Hahn-Platz 8
D-24118 Kiel
Germany
[email protected]
 +49 431 8802558
Ewa BIELECKA
Jagiellonian University
Dept. Microbiology
Gornostajowa 7
PL-30-387 Krakow
Poland
[email protected]
 +48 12 664 63 87
Ulrich AUF DEM KELLER
ETH Zurich
Institute of Molecular Health
Sciences
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Wolfram BODE
Max Planck Institute of
Biochemistry
Proteinase Research Group
Am Klopferspitz 18
D-82152 Martinsried
Germany
[email protected]
 +49 89 8504807
Nathalie BEAUFORT
Klinikum der Universität
München
Institute for Stroke and
Dementia Research
Feodor-Lynen-Straße 17
D-81377 Munich
Germany
[email protected]
 +49 89 4400 46175
Melanie BÖRRIES
University of Freiburg
Institute of Molecular Medicine
and Cell Research
Stefan-Meier-Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9626
Hans BRANDSTETTER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7270
Christoph BECKER-PAULY
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8807118
I
Sarah Marie BRAUN
University of Freiburg
Institute for Molecular
Medicine and Cell
Research
Stefan-Meier-Strasse 17
D-79104 Freiburg
Germany
[email protected]
Haissi CUI
Technische Universität
München
Dept. Biochemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 12891
Klaudia BRIX
Jacobs University Bremen
Department of Life Sciences
and Chemistry
Campus Ring 6
D-28759 Bremen
Germany
[email protected]
 +49 421 200 3246
Sven O. DAHMS
Leibniz Institute for Age
Research
Fritz Lipmann Institute Jena
Beutenbergstraße 21
D-07745 Jena
Germany
[email protected]
 +49 3641 656208
Roberta BURDEN
Queen’s University Belfast
School of Pharmacy
97 Lisburn Road
Belfast, BT9 7BL
Northern Ireland, UK
[email protected]
 +44 28 9097 2176
Elfriede DALL
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7278
Hauke BUSCH
University of Freiburg
Institute of Molecular
Medicine and Cell Research
Stefan-Meier-Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 2039626
Therese DAU
Helmholtz Zentrum München
Comprehensive Pneumology
Center
Max-Lebsche-Platz 31
D-81377 Munich
Germany
[email protected]
 +49 89 31871653
Athena CHALARIS-RISSMANN
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8801478
Christine DOHERTY
University of Oxford
Kennedy Institute of
Rheumatology
Roosevelt Drive, Headington
OX3 7FY, Oxford
United Kingdom
[email protected]
 +44 1865 612600
II
Marcin DRAG
Wroclaw University of
Technology
Dept. Bioorganic Chemistry
Wyb. Wyspianskiego 27
PL-50-370 Wroclaw
Poland
[email protected]
 +48 71 320 4526
Matthias FELTEN
University of Mainz
Dept. Cell and Matrix Biology
Johann-Joachim-Becher Weg
9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 39 24271
Christian DUBIELLA
Technische Universität
München
Dept. Biochemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 13354
Melanie FÖLL
University of Freiburg
Institute for Molecular
Medicine and Cell Research
Stefan Meier Strasse 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9614
Grzegorz DUBIN
Jagiellonian University
Malopolska Centre of
Biotechnology
Gornostajowa 7a
PL-30-387 Krakow
Poland
[email protected]
 +48 12 6646362
Regina FREIER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7277
Fabian EGLI
ETH Zurich
Institute of Molecular Health
Sciences
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Hans FRITZ
Ludwig-MaximiliansUniversity Munich
Dept. Clinical Chemistry and
Clinical Biochemistry
Nußbaumstraße 20
D-80336 Munich
Germany
[email protected]
 +49 8178 1534
Han FANG
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7200
Ruth GEISS-FRIEDLANDER
University Medical Center of
Goettingen
Dept. Molecular Biology
Humboldtallee 23
D-37073 Goettingen
Germany
[email protected]
 +49 55 139 5984
III
Przemyslaw GOLIK
Jagiellonian University
Malopolska Centre of
Biotechnology
Gornostajowa 7a
PL-30-387 Krakow
Poland
[email protected]
 +48 12 609886426
Barbara GRÜNWALD
Klinikum rechts der Isar der
TU München
Institut für Experimentelle
Onkologie und
Therapieforschung
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 4459
Alejandro GOMEZ-AULI
University of Freiburg
Institute of Molecular
Medicine and Cell Research
Stefan-Meier-Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9603
Carla GUARINO
Centre d'Etude des Pathologies
Respiratoires
INSERM U1100/EA6305
Faculté de médecine de Tours
10 Bd Tonnellé
F-37032 Tours
France
[email protected]
 +33 2 47 36 62 53
Jessica GÖTZFRIED
Helmholtz Zentrum München
Comprehensive Pneumology
Center
Max-Lebsche-Platz 31
D-81377 Munich
Germany
jessica.goetzfried@helmholtz
-muenchen.de
 +49 89 31871686
Shihui GUO
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7283
Michael GROLL
Technische Universität
München
Dept. Biochemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 13361
Angelina HAHLBROCK
University Medical Center of
Mainz
Molecular and Cellular
Oncology, ENT
Langenbeckstr. 1
D-55131 Mainz
Germany
[email protected]
 +49 6131 17 6030
Maresa GRUNDHUBER
Ludwig-MaximiliansUniversity Munich
Institute of Laboratory
Medicine
Nussbaumstraße 20
D-80336 Munich
Germany
[email protected]
 +49 89 4400 52597
Yveline HAMON
Centre d'Etude des
Pathologies Respiratoires
INSERM U1100/EA6305
Faculté de médecine de Tours
10 Bd Tonnellé
F-37032 Tours
France
[email protected]
 +33 2 47 36 62 53
IV
Lisa HINKOFER
Helmholtz Zentrum München
Comprehensive Pneumology
Center
Max-Lebsche-Platz 31
D-81377 Munich
Germany
[email protected]
 +49 89 31871627
Felix JÄCKLE
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 157 543 688 50
Dieter JENNE
Helmholtz Center Munich &
Max-Planck Institute of
Neurobiology
Max-Lebsche-Platz 31
D-81377 Munich
Germany
[email protected]
 +49 89 31874664
Caroline HOPPE
Jacobs University Bremen
Dept. Life Sciences and
Chemistry
Campus Ring 1
D-28759 Bremen
Germany
[email protected]
 +49 163160 9056
Konstantin KARMILIN
University of Mainz
Dept. Cell and Matrix Biology
Johann-Joachim-Becher Weg
9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 39 24271
Pitter HUESGEN
Forschungszentrum Jülich
Central Institute for
Engineering, Electronics and
Analytics, ZEA-3 Analytics
Wilhelm-Johnen-Str
D-52428 Jülich
Germany
[email protected]
 +49 2461 61 6873
Nežka KAVČIČ
Jožef Stefan Institute
Dept. Biochemistry, Molecular
and Structural Biology
Jamova cesta 39
SI-1000 Ljubljana
Slovenia
[email protected]
 +3861 477 3753
Line HYLTOFT KRISTENSEN
University of Salzburg
Dept. Molecular Biology &
Novo Nordisk
Biopharmaceutical Research
Unit
Novo Nordisk Park
DK-2760 Måløv
Denmark
[email protected]
 +45 3079 8035
Anna KEPPNER
University of Lausanne
Dept. Pharmacology and
Toxicology
Rue du Bugnon 27
CH-1005 Lausanne
Switzerland
[email protected]
 + 41 21 692 54 26
Yoshifumi ITOH
University of Oxford
Kennedy Institute of
Rheumatology
Roosevelt Drive, Headington
Oxford OX3 7FY
United Kingdom
[email protected]
 +44 1865 612647
V
Anett KETSCHER
University of Freiburg
Institute of Molecular
Medicine and Cell
Research
Stefan-Meier-Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9505
Lovro KRAMER
Jožef Stefan Institute
Dept. Biochemistry,
Molecular and Structural
Biology
Jamova 39
SI-1000 Ljubljana
Slovenia
[email protected]
 +386 1477 35 10
Shirley KNAUER
University Duisburg-Essen
Molecular Biology II
Universitätsstrasse 5
D-45141 Essen
Germany
[email protected]
 +49 201 183 4987
Eileen KROLL
Jacobs University Bremen
Dept. Life Sciences and
Chemistry
Campus Ring 1
D-28759 Bremen
Germany
[email protected]
 +49 421 200 3584
Tobias KOCKMANN
ETH Zurich
Institute of Molecular Health
Sciences
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Achim KRUEGER
Klinikum rechts der Isar der
Technischen Universität
München
Institut für Molekulare
Immunologie und
Experimentelle Onkologie
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 4463
Brice KORKMAZ
Centre d'Etude des
Pathologies Respiratoires
INSERM U1100/EA6305
Faculté de médecine de Tours
10 Bd Tonnellé
F-37032 Tours
France
[email protected]
 +33 2 47 36 62 53
Katarzyna KUŚKA
Jagiellonian University
Malopolska Centre of
Biotechnology
Gornostajowa 7a
PL-30-387 Krakow
Poland
[email protected]
 +48 792516779
Ludwig KORNREITER
Omnibusunternehmen
Habermayr
Schleifmühlweg 14
D-86633 Neuburg/Donau
Germany
[email protected]
 +49 171 6519414
Timon LANDINGER
Ludwig-MaximiliansUniversity Munich Institute for
Stroke and Dementia Research
Feodor-Lynen-Straße 17
D- 81377 Munich
Germany
[email protected]
 +49 89 4400 48174
VI
Michael NIEMEYER
Fraunhofer Institute for Cell
Therapy and Immunology (IZI)
Dept. Drug Design and Target
Validation (MWT)
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 131428 00
Michaela LASSACHER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7200
Christine LEHMANN
MRC National Institute for
Medical Research
Division of Parasitology
The Ridgeway, Mill Hill
London NW7 1AA
United Kingdom
[email protected]
 +44 20 8816 2668
Anke OHLER
University of Mainz
Dept. Cell and Matrix Biology
Johannes-von-Müller-Weg 6
D-55124 Mainz
Germany
[email protected]
 +49 6131 39 26656
Gondichatnahalli M.
LINGARAJU
Friedrich Miescher Institute
for Biomedical Research
Maulbeerstrasse 66
CH-4058 Basel
Switzerland
[email protected]
 + 41 76 4714413
Mario OLF
University of Mainz
Dept. Cell and Matrix Biology
Johannes-Joachim-Becher Weg
9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 24271
Viktor MAGDOLEN
Frauenklinik der TU
München
Klinische Forschergruppe
Klinikum rechts der Isar
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 2493
Aleksandra PECAK
Jagiellonian University
Malopolska Centre of
Biotechnology
Gornostajowa 7a
PL-30-387 Krakow
Poland
[email protected]
 +48 12 664 5369
Miryam MÜLLER
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8807112
Christoph PETERS
University of Freiburg
Institute for Molecular
Medicine and Cell Research
Stefan-Meier-Strasse 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9601
VII
Martin RENATUS
Novartis Institutes for Biomedical Research
Fabrikstrasse 2
CH-4002 Basel
Switzerland
[email protected]
 +41 76 440 9958
Marcin POREBA
Wroclaw University of
Technology
Dept. Bioorganic Chemistry
Wyb. Wyspianskiego 27
PL-50-370 Wroclaw
Poland
[email protected]
 +48 71 320 24 55
Steffen RIETHMÜLLER
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8802215
Johannes PROX
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8802215
Björn RABE
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8801678
Wioletta RUT
Wroclaw University of
Technology
Dept. Bioorganic Chemistry
Wyb. Wyspianskiego 27
PL-50-370 Wroclaw
Poland
[email protected]
 +48 71 320 24 55
Yesid A. RAMIREZ
University of Wuerzburg
Dept. Structural Biology
Josef-Schneider-Straße 2
D- 97080 Würzburg
Germany
[email protected]
 +49 176 98258000
Fabio SABINO
ETH Zurich
Institute of Molecular Health
Sciences
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Thomas REINHECKEL
Albert-Ludwigs-University of
Freiburg
Institute of Molecular
Medicine and Cell Research
Stefan Meier Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9606
Guy SALVESEN
Sanford-Burnham Medical
Research Institute
10901 North Torrey Pines
Road
La Jolla, CA 92037
USA
gsalvesen@sanfordburnham.
org
 +1 858 646 3114
VIII
Magdalena SCHACHERL
University of Cologne
Institute of Biochemistry
Otto-Fischer-Str. 14
D-50674 Cologne
Germany
[email protected]
 +49 221 470 3212
Stefanie SCHMIDT
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8801478
Oliver SCHILLING
University of Freiburg
Institute for Molecular
Medicine and Cell Research
Stefan Meier Strasse 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 2039615
Dirk SCHMIDT-ARRAS
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8807112
Manfred SCHMITT
Technische Universität
München
Dept. Obstetrics and
Gynecology (Frauenklinik)
Ismaningerstraße 22
D-81675 München
Germany
[email protected]
 +49 89 4140 2449
Stephan SCHILLING
Fraunhofer Institute for Cell
Therapy and Immunology
(IZI)
Dept. Drug Design and Target
Validation (MWT)
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 131428 00
Esther SCHÖNAUER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7277
Pascal SCHLAGE
ETH Zurich
Institute of Molecular Health
Sciences
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Øyvind L. SCHÖNBERGER
Munich
[email protected]
 +43 152 0643 4404
Frederike SCHMIDT
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8802215
IX
Kristin SCHUBERT
University of Oxford
Kennedy Institute of
Rheumatology
Roosevelt Drive, Headington
OX3 7FY, Oxford
United Kingdom
[email protected].
ac.uk
 +44 1865 612600
Christian SOMMERHOFF
Klinikum der Universität
München
Institute of Laboratory
Medicine
Nussbaumstraße 20
D-80336 Munich
Germany
[email protected]
 +49 89 4400 55153
Neele SCHUMACHER
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8801478
Roland H. STAUBER
University Medical Center
of Mainz
Molecular and Cellular
Oncology
Langenbeckstr. 1
D-55131 Mainz
Germany
[email protected]
 +49 6131 17 7002
Jeanette SCHWARZ
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8801478
Walter STÖCKER
University of Mainz
Institute of Zoology, Cell and
Matrix Biology
Johannes-von-Müller-Weg 6
D-55128 Mainz
Germany
[email protected]
 +49 6221 3924273
Christopher SCOTT
Queen’s University Belfast
School of Pharmacy
97 Lisburn Road
Belfast, BT9 7BL
Northern Ireland, UK
[email protected]
 +44 28 9097 2350
Ed STURROCK
University of Cape Town
Institute of Infectious Disease
and Molecular Medicine
Suite 3.13, Wernher and Beit
Building
Anzio Road, Observatory 7925
South Africa
[email protected]
 +27 21 4066312
Pernille SØGAARD
University of Oxford
Kennedy Institute of
Rheumatology
Roosevelt Drive, Headington
OX3 7FY, Oxford
United Kingdom
[email protected]
 +44 7450645204
Claudia TREDUP
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 176 32531129
X
Linda TROEBERG
University of Oxford
Kennedy Institute of
Rheumatology
Roosevelt Drive, Headington
OX3 7FY, Oxford
United Kingdom
[email protected]
.uk
 +44 1865 612600
Ping WANG
Technische Universität
München
Klinische Forschergruppe der
Frauenklinik
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 7412
Christian TÜTING
Fraunhofer Institute for Cell
Therapy and Immunology (IZI)
Dept. Drug Design and Target
Validation (MWT)
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
christian.tü[email protected]
 +49 345 131428 00
Silvio WEBER
Technische Universität Dresden
Dept. Pharmacology and
Toxicology
Fetscherstraße 74
D-01307 Dresden
Germany
[email protected]
 +49 351 458 6278
Hagen WESTPHAL
University of Mainz
Dept. Cell and Matrix Biology
Johann-Joachim-Becher Weg
9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 39 24271
Marie-Theres VIELBERG
Technische Universität
München
Dept. Biochemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 13354
Sebastian WETZEL
University of Kiel
Institute of Biochemistry
Otto-Hahn-Platz 9
D-24118 Kiel
Germany
[email protected]
 +49 431 880 2219
Rudolf WACHTEL
Technische Universität
München
Dept. Chemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 13744
James C. WHISSTOCK
Monash University
Dept. Biochemistry &
Molecular Biology
Bldg 77, Wellington Road
Clayton, Victoria 3800
Australia
[email protected]
 +61 3 9902 9312
Birgit WALDNER
University of Innsbruck
Institute of General, Inorganic
and Theoretical Chemistry
Innrain 82
A-6020 Innsbruck
Austria
[email protected]
 +43 512 507 57137
XI
Janja ZAVRŠNIK
Jožef Stefan Institute
Dept. Biochemistry, Molecular
and Structural Biology
Jamova 39
SI-1000 Ljubljana
Slovenia
[email protected]
 +386 1 4773 510
Rielana WICHERT
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8802215
Richard WILKINSON
Queen’s University Belfast
School of Pharmacy
97 Lisburn Road
Belfast, BT9 7BL
Northern Ireland, UK
[email protected]
 +44 28 9097 2164
Friederike ZUNKE
University of Kiel
Institute of Biochemistry
Rudolf-Höber-Straße 1
D-24118 Kiel
Germany
[email protected]
 +49 431 8802219
Désirée WÜNSCH
University Medical Center of
Mainz
Molecular and Cellular
Oncology, ENT
Langenbeckstr. 1
D-55131 Mainz
Germany
[email protected]
 +49 6131 17 6030
Chun-Yao YANG
University of Oxford
Kennedy Institute of
Rheumatology
Roosevelt Drive, Headington
OX3 7FY, Oxford
United Kingdom
[email protected]
 +44 1865 612600
Florian ZAUNER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7279
XII