Oral/Poster Finalist - WCPG 2015

Transcription

XXIII
RD
World Congress of
Psychiatric Genetics
BUILDING ON SUCCESS
PROGRAM BOOK
OCTOBER 16-20, 2015
TORONTO, CANADA
To all Participants of the World Congress of Psychiatric Genetics (WCPG XXIII):
It is my pleasure to welcome conference attendees to the centre of Canadian hospitality, the great city of Toronto, and
the classy Fairmont Royal York Hotel. The hotel is linked to the full subway metro system, as well as the trans-Canada
railway network. In mid-October, Toronto features moderate temperatures with daytime highs of 15°C (60°F) and beautiful
autumnal foliage. Toronto is one of the most multicultural cities in the world, with each of the major ethnicities celebrating
their character via food, music and traditions in their localities across the greater Toronto area.
The theme of our meeting this year is ‘Building on Success’. The recent success of the field has been the identification
of multiple genes associated with schizophrenia, bipolar disorder, autism, and other phenotypes using GWAS methods on
large samples. We will hear presentations this October in Toronto that will reveal additional discoveries in other disorders.
The next challenge is to use these findings to derive pathways that will yield important biological information regarding
the etiology and new possibilities for clinical intervention. The GWAS findings are further supported by the parallel intense
activity started by the ENCODE project, in genome-wide documentation of functional roles of SNPs, including remote
regulatory sites, 3D chromosomal conformation, and epigenetic effects.
Our plenary lectures will be top notch, with Nancy Cox kicking off the opening by providing her wise and insightful perspective
on the complexities in the search for genes in common illnesses. The senior statesman of mitochondrial genetics, Doug
Wallace, will inform us on this separate genome, Art Petronis on the latest developments in epigenetics, and Tom Hudson
on the fast moving area of genomics in cancer. Jeff Lieberman, past president of the American Psychiatric Association, will
comment on psychiatric nosology, the battle against stigma, and the future we face in psychiatric research. Nobel Laureate
(2000) Arvid Carlsson will wrap up the conference by describing his long career in brain research, the roles of dopamine in
neuropsychiatric disorders, and his latest novel drug for treatment of Huntington’s Disease.
The roster of symposia, and individual talks, scored and selected by our international Program Committee, is particularly
exciting with new developments in GWAS analyses, CNVs, polygenic score assessments, gene pathway development, ADHD
gene discoveries, mitochondrial mechanisms, and much more. This year we received a particularly strong set of genetic
studies of substance abuse, a long neglected area of our field, and thus we have a proportionately higher representation
of this area in the program. We will dedicate an important session to the topic of genetic testing and ethical/legal issues
in psychiatric genetics, led by our President, Dr. Francis McMahon, with opportunity for extensive audience participation.
The program is the result of a great deal of hard work by our Program Committee, and I would like to thank them for their
important contribution to the success of our congress, including review and scoring of many hundreds of abstracts.
The WCPG is linked to the Pharmacogenetics in Psychiatry meeting, to be held at the nearby King Edward Hotel, on
Thursday, October 15. This annual meeting, organized by Dr. Anil Malhotra, has been running successfully since 2002. Each
year the field of Pharmacogenetics makes advances toward meaningful interventions in medication treatment strategies in
psychiatric disorders, and this year will see further GWAS results as well as clinical trial outcomes.
Our Education Day on Friday, October 16, at the Fairmont Royal York will feature a full roster of expert presenters on
the important topics of 2015, including statistical genetics, alternate phenotypes, and preclinical models. In parallel to
the Education Day will be the now rather large Psychiatric Genetics Consortium meeting, probably the most important
collaborative network in our field.
The congress social event will be at the top of the Canadian National (CN) Tower, one of the tallest buildings in the world,
on Sunday eve, October 18 -- it is a ticketed event.
During our conference, the adjacent Air Canada Centre arena will feature Ricky Martin on October 15, Paul McCartney
on Saturday, October 17, and The Who on October 19, just 300 m from our conference venue. The former Beatle will be
upstaged however, on Saturday night, by our WCPG Music and Mental Health workshop/concert, led by Drs. Becky Inkster
and Akeem Sule from Cambridge University. For daytime activities, a short 1.5 hour bus trip from Toronto will take visitors
to Niagara Falls, and the festive grape harvest in this unique wine region will be in full swing in October.
I think you can readily see that Toronto is a vibrant, diverse, and sophisticated international venue that I am sure will prove
to be an outstanding host for WCPG 2015!
Sincerely,
James L. Kennedy M.D., MSc, FRCPC, FRSC
Centre for Addiction and Mental Health,
University of Toronto
TABLE OF CONTENTS
Floor Plans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
Meeting Announcements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Exhibitors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
Committees. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Awards. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Plenary Speakers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Friday, October 16, 2015. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Saturday, October 17, 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
Sunday, October 18, 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
Monday, October 19, 2015. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Tuesday, October 20, 2015. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
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FLOOR PLANS
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REGISTRATION:
Registration for the World Congress is located in the Fairmont Royal York Hotel.
On Friday, October 16, we will be in the Imperial Foyer (1st floor) from 7:00 a.m. until
2:00 p.m. Registration will move for the remainder of the congress to the 2nd level
foyer at 2:30 p.m. on Friday, October 16.
Date
Friday, October 16th
Saturday, October 17th
Sunday, October 18th
Monday, October 19th
Tuesday, October 20th
Time
7:00 a.m. - 2:00 p.m.
2:30 p.m. - 6:00 p.m.
7:30 a.m. - 6:00 p.m.
7:30 a.m. - 7:00 p.m.
7:00 a.m. - 6:00 p.m.
8:00 a.m. - 12:00 p.m.
Location
Imperial Foyer
2nd Level Foyer
2nd Level Foyer
2nd Level Foyer
2nd Level Foyer
2nd Level Foyer
Registration Types:
Participant: Scientific Attendee
Student: Full-time graduate student, medical student or in the first two years of a
post-doctoral fellowship program at a university in a relevant field.
Registration to the 2015 World Congress includes membership to the International
Society of Psychiatric Genetics from the date of the conference through October
31, 2017. As a member of the Society, you are invited to attend the annual business
meeting.
SPEAKER READY ROOM:
The Speaker Ready Room is located in the Algonquin room on the Main Mezzanine
level.
Date
Time
7:30 a.m. - 6:00 p.m.
7:30 a.m. - 6:00 p.m.
7:30 a.m. - 7:00 p.m.
7:30 a.m. - 6:00 p.m.
8:00 a.m. - 11:30 a.m.
CME:
Accreditation:
Royal College of Physicians and Surgeons of Canada – Section 1
This event is an Accredited Group Learning Activity (Section 1) as defined by
the Maintenance of Certification Program of the Royal College of Physicians and
Surgeons of Canada, approved by Continuing Professional Development, Faculty of
Medicine, University of Toronto. The maximum number of credit hours available is 29.5.
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Meeting Announcements
MEETING ANNOUNCEMENTS
CME (continued):
Through an agreement between the Royal College of Physicians and Surgeons of
Canada and the American Medical Association, physicians may convert Royal College
MOC credits to AMA PRA Category 1 Credits™. Information on the process to convert
Royal College MOC credit to AMA credit can be found at www.ama-assn.org. The
maximum number of credit hours available is 29.5.
There will be a $40.00 charge for scientific registrants to obtain CME credits.
LEARNING OBJECTIVES:
As a result of participating in this activity, participants should be able to:
•
•
•
•
•
Analyze research consensus about how psychiatric disorders are
inherited.
Correlate morbid risk and the development of specific psychiatric
disease when other family members have the illness.
Assess latest gene findings that have been replicated.
Utilize genetic testing on patients.
Illustrate language used in psychiatric genetic studies.
CONFERENCE EVALUATION:
All conference attendees are urged to complete an evaluation of the meeting.
Attendees who request CME credit for the meeting are required to complete the
evaluation. This form is available on the WCPG 2015 website only. All evaluations
must be completed by November 23, 2015.
POSTERS:
There will be three formal poster presentation sessions held each day, Saturday
through Monday. Poster presenters are encouraged to be at their poster during their
scheduled presentations. All authors are encouraged to upload their poster to the
e-poster viewing site. Attendees will be able to view these e-posters online during and
after the meeting.
Poster Session I: Saturday, October 17, 12:30 p.m. - 2:30 p.m.
Poster Session II: Sunday, October 18, 11:00 a.m. - 1:00 p.m.
Poster Session III: Monday, October 19, 4:45 p.m. - 6:45 p.m.
ABSTRACTS:
Conference abstracts will be published in 2015 in a special edition of European
Neuropsychopharmacology. To access the abstracts, please view 2015.ispg.net.
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DISCLOSURES:
Disclosures for 2015 plenary speakers, education day speakers, symposia speakers,
oral presenters and poster presenters may be found online at www.WCPG2015.org.
Copies of presenters’ disclosures will be available at the registration desk.
INSURANCE:
Neither the Local Organizing Committee nor the Congress Secretariat and organizers
accept any liability for damages and/or losses of any kind which may be incurred to
the Congress participants or by any persons accompanying them, both during the
official activities and excursions. Participation in all tours and events is at one’s own
risk. Participants are advised to obtain insurance against loss, accidents, or damage
that could be incurred during the Congress. Congress participants are encouraged to
insure valuables.
VIDEOTAPING:
Attendees may not photograph, videotape or audiotape presentations at the
conference without prior permission from the session chair and presenter.
CORPORATE SUPPORTERS:
Educational Grants:
The International Society of Psychiatric Genetics express appreciation to the following
companies for their support of this educational activity by providing an unrestricted
educational grant:
Institute of Psychiatric Phenomics and Genomics (IPPG),
Medical Center of the University of Munich
Amgen
Satellite Sessions:
‘CRESTAR’ Development of Pharmacogenomic Biomarkers for Schizophrenia, Satellite
Symposium
Saturday, October 17, 6:00 p.m. - 7:30 p.m.
*Please note the symposium is not a CME accredited session.
GOVERNMENT SUPPORTERS: NIAAA: 5R13AA017055-08, Nurnberger, John I.,
Conference Support for World Congress on Psychiatric Genetics
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EXHIBITORS
Exhibits are located in the 2nd level foyer of the Fairmont Royal York. Exhibitors
include:
DNA GENOTEK
MACROGEN
Exhibitors
RUCDR INFINITE BIOLOGICS
Exhibits will be open during the hours listed below. Attendees are encouraged to stop
by and visit.
3:00 p.m. - 6:00 p.m.
7:30 a.m. - 6:00 p.m.
7:30 a.m. - 7:00 p.m.
7:30 a.m. - 6:00 p.m.
8:00 a.m. - 11:30 a.m.
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COMMITTEES
2015 WCPG CONGRESS CHAIR
James L. Kennedy, M.D., FRCPC, FRSC, Director Neuroscience Research,
Centre for Addiction and Mental Health, University of Toronto
2015 PROGRAM COMMITTEE
Art Petronis, Canada
Miguel Prieto, Chile
Shaun Purcell, USA
Peggy Richter, Canada
Marcella Rietschel, Germany
Dan Rujescu, Germany
Akira Sawa, USA
Martin Schalling, Sweden
Peter Schofield, Australia
Pak Sham, China
Jordan Smoller, USA
John Strauss, Canada
Bittianda Thelma, India
Homero Vallada, Brazil
Aristotle Voineskos, Canada
John Vincent, Canada
Hiroshi Yoneda, Japan
EARLY CAREER INVESTIGATOR SELECTION COMMITTEE
John Nurnberger, USA – Chair
Lynn DeLisi, USA
Ryota Hashimoto, Japan
James L. Kennedy, Canada
Thomas Schulze, Germany
Thorgeir Thorgeirsson, Iceland
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Committees
Cathy Barr, Canada
Anne Bassett, Canada
Danielle Cath, Netherlands
Lynn DeLisi, USA
Barbara Franke, Netherlands
Lin He, China
John Kelsoe, USA
Joanne Knight, Canada
Beni Lerer, Israel
Cathryn Lewis, United Kingdom
Daniela Lobo, Canada
Anil Malhotra, USA
Nick Martin, Australia
Manuel Mattheisen, Denmark
Ole Mors, Denmark
Benjamin Neale, USA
Daniel Müeller, Canada
Michael O’Donovan, United Kingdom
COMMITTEES
ISPG EXECUTIVE COMMITTEE
President: Francis McMahon, M.D.
Bethesda, MD, USA
Secretary: Thomas Schulze, M.D.
Munich, Germany
Vice-President: Marcella Rietschel, M.D.
Mannheim, Germany
Treasurer: John Rice, Ph.D.
St. Louis, MO, USA
Committees
ISPG BOARD OF DIRECTORS
Sarah Bergen, Ph.D.
Stockholm, Sweden
Markus Nöethen, M.D.
Bonn, Germany
Elisabeth Binder, M.D., Ph.D.
Munich, Germany
John Nurnberger, M.D., Ph.D.
Indianapolis, IN, USA
Margit Burmeister, Ph.D.
Ann Arbor, MI, USA
Jimmy Potash, M.D.
Iowa City, Iowa, USA
Elliott Gershon, M.D.
Chicago, IL, USA
Dan Rujescu, M.D., Ph.D.
Halle, Germany
Michael Gill, M.D.
Dublin, Ireland
Jonathan Sebat, Ph.D.
La Jolla, CA, USA
John Kelsoe, M.D.
La Jolla, CA, USA
Jordan Smoller, M.D.
Boston, MA, USA
James L. Kennedy, M.D.
Toronto, ON, Canada
Patrick Sullivan, M.D.
Chapel Hill, NC, USA
Douglas Levinson, M.D.
Stanford, CA, USA
ISPG PRIZE COMMITTEE
James Potash, USA – Chair
Elisabeth Binder, Germany
Margit Burmeister, USA
Sven Cichon, Germany
Pablo Gejman, USA
Tadafumi Kato, Japan
Phillip Mitchell, Australia
Page 8
AWARDS
The Prize Committee and Board of Directors of the International Society of Psychiatric
Genetics are pleased to announce the 2015 Honorific Award Winners:
THE SNOW AND MING TSUANG LIFETIME ACHIEVEMENT AWARD:
The Lifetime Achievement Award is awarded each year by the ISPG to a scientist who
made a major contribution to the advancement of the field of Psychiatric Genetics.
Page 9
Awards
Professor Sir Michael Owen Ph.D.,
FRCPsych, FMedSci, FLSW
Mike Owen is Director of the Medical
Research Council’s Centre for
Neuropsychiatric Genetics and Genomics,
and Head of the Institute of Psychological
Medicine and Clinical Neurosciences in
Cardiff University. He has researched
the genetics and genomics of a variety
of psychiatric disorders in particular
schizophrenia and Alzheimer disease
since 1987. He has been particularly
interested in what genetic findings tell us
about the biological mechanisms underlying psychiatric disorders and the possible
relationships between disorders. As well as continuing his work on psychiatric
genetics, he is currently undertaking research aimed at translating genetic findings
into a greater understanding of disease mechanisms using a variety of neuroscience
and epidemiological approaches. In addition, he continues to work as a consultant
in general adult psychiatry. He served on the Board of Directors of ISPG from 19932014 and was President from 2000-2005. He was awarded the Stromgren Medal for
psychiatric research in 2011, the Lieber Prize for schizophrenia research in 2012, and
the William K. Warren Distinguished Investigator Award for schizophrenia research in
2013. He has published over 600 scientific papers and is a Thompson Reuters Highly
Cited Researcher. He was knighted for services to psychiatry and neuroscience in
2014.
AWARDS
THEODORE REICH YOUNG INVESTIGATOR AWARD:
Theodore (Ted) Reich (1938 – 2003) was the first President of ISPG and was both
an outstanding researcher and mentor to young scientists. The award is made for
published work on psychiatric genetics that is of exceptional merit to candidates who
are 40 years or younger in the year of their nomination.
Awards
Sarah Medland, Ph.D.
Associate Professor Sarah Medland is a statistical
geneticist working on mental health and neurological
traits. She is the head of the Quantitative Genetics team
at the QIMR Berghofer Medical Research Institute in
Brisbane, Australia. Sarah is best known for her work
as chair of the genetics team of ENIGMA neuro-imaging
genetics consortium which focuses on identifying genetic
variants influencing brain structure in healthy and diseasefocused cohorts.
Sarah completed her Ph.D. at the University of
Queensland (Australia) in the Genetic Epidemiology of
Lateralization under the supervision of Dr. Margie Wright
and Dr. David Duffy. In 2006 she was awarded a National
Health and Medical Research Council Sidney Sax Fellowship and moved to the US to
undertake post-doctoral studies with Professor Mike Neale at the Virginia Institute of
Psychiatric and Behavioural Genetics. Sarah returned to Australia in 2009 to continue
working on addiction and psychiatric genetics with Professor Nick Martin at the
Queensland Institute of Medical Research. In 2012, she was awarded an Australian
Research Council Future Fellowship to further her work on the genetics of ADHD and
in 2014 was awarded an Emerging research leader Visiting Professorship from the
Royal Netherlands Academy of Arts and Sciences.
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AWARDS
RICHARD TODD AWARD:
Richard Todd (1952 – 2008) was an internationally known expert on the influences
of genetics and environment on psychiatric illness in children. The award is given by
the Awards Committee for oral presentation in the category of Childhood Psychiatric
Disorders.
Christie Burton, Ph.D. is a Research Associate working
with Drs. Paul Arnold (University of Calgary), Russell
Schachar and Jennifer Crosbie in the departments of
Genetics & Genome Biology & Psychiatry at the Hospital
for Sick Children, Toronto, Canada. Dr. Burton received
her Ph.D. in Psychology and Neuroscience from the
University of Toronto, Canada in 2012. Her previous
research focused on animal models of behaviours
relevant to drug addiction (e.g., impulsivity) in adolescent
rodents under the supervision of Dr. Paul Fletcher at the
Centre of Addiction and Mental Health, Toronto, Canada.
Her current work, which began during her post-doctoral fellowship in 2012, focuses
on the genomic underpinnings of psychiatric and cognitive traits related to AttentionDeficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD)
in both large community samples and clinical samples of children and adolescents.
She is a member of the ADHD and OCD working groups of the Psychiatric Genomics
Consortium and the International Obsessive-Compulsive Disorder Foundation –
Genomics Collaborative. In addition, she also studies the clinical, cognitive and
genetic correlates of hoarding in children and adolescents with Dr. Jennifer Crosbie
(Sickkids), Dr. Arnold and Dr. Noam Soreni (McMaster).
ELLIOT GERSHON PAPER OF THE YEAR AWARDS:
Ripke, S, Neale, BM, Corvin, A, Walters, JTR, Farh, K-H, Holmans, P a., Lee, P, BulikSullivan, B, Collier, D a., Huang, H, Pers, TH, Agartz, I, Agerbo, E, Albus, M, Alexander, M,
Amin, F, Bacanu, S a., Begemann, M, Belliveau Jr, R a., Bene, J, Bergen, SE, Bevilacqua,
E, Bigdeli, TB, Black, DW, Bruggeman, R, Buccola, NG, Buckner, RL, Byerley, W, Cahn,
W, Cai, G, Campion, D, Cantor, RM, Carr, VJ, Carrera, N, Catts, S V., Chambert, KD, Chan,
RCK, Chen, RYL, Chen, EYH, Cheng, W, Cheung, EFC, Ann Chong, S, Robert Cloninger,
C, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, JJ, Curtis, D, Davidson, M,
Davis, KL, Degenhardt, F, Del Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S,
Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson,
J, Escott-Price, V, Essioux, L, Fanous, AH, Farrell, MS, Frank, J, Franke, L, Freedman, R,
Freimer, NB, Friedl, M, Friedman, JI, Fromer, M, Genovese, G, Georgieva, L, Giegling, I,
Giusti-Rodríguez, P, Godard, S, Goldstein, JI, Golimbet, V, Gopal, S, Gratten, J, de Haan,
L, Hammer, C, Hamshere, ML, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, AM,
Henskens, F a., Herms, S, Hirschhorn, JN, Hoffmann, P, Hofman, A, Hollegaard, M V.,
Hougaard, DM, et al. 2014. Biological Insights from 108 Schizophrenia-associated
Genetic Loci. Nature 511: 421–7
Page 11
Awards
In honor of Dr. Elliot Gershon, the International Society of Psychiatric Genetics
presents the Gershon Paper of the Year Award to a recipient who has been published
in the past year (June, 2013 to present) in the psychiatric genetics field.
AWARDS
ELLIOT GERSHON PAPER OF THE YEAR AWARDS (continued):
Awards
Michael O’Donovan is a clinically active academic
with qualifications in medicine (MBChB) and science
(Ph.D.). He is Professor of Psychiatric Genetics and
Deputy Director of the MRC Centre for Neuropsychiatric
Genetics and Genomics at Cardiff University. He has
been working in psychiatric genetics since 1993 and
has over 400 peer reviewed publications in this area
spanning schizophrenia, bipolar disorder, depression,
ADHD, Alzheimer’s Disease and Pharmacogenetics. He
is an active member of several groups of the Psychiatric
Genomics Consortium and is currently the Chair of the
Schizophrenia Working Group of the PGC.
Since the early days of his medical training Stephan Ripke,
M.D., Ph.D. has pursued his interest in computational
methods in genetic research. The rare combination of
strong computational and statistical background with
medical /clinical training has allowed to him to execute
all necessary steps from receiving raw genotypic data,
through all necessary computational steps (QC, imputation,
meta-analysis, PCA, etc.) up to drawing medical/clinical
conclusions from the results. Moreover during the recent
years, through his work as the major analyst for most
of the work of the Psychiatric Genomics Consortium – the
biggest collaborative experiment in psychiatric genetics
– he has developed a strong sense for the limitations of
current research, and the future needs of the field if it is to continue the overwhelming
success of recent years. Stephan Ripke currently holds positions at MGH, Boston
and at Charite, Berlin and will continue co-leading the central analysis team of the
Psychiatric Genomics Consortium.
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AWARDS
EARLY CAREER INVESTIGATOR PROGRAM TRAVEL AWARDS
The Early Career Investigator Program is sponsored by grants from the NIAAA and the
International Society of Psychiatric Genetics. The Society is grateful for their support
that makes the travel awards possible.
Congratulations to the 2015 ECIP Travel Awardees:
Bonnie Alberry
Canada
Prachi Kukshal
India
Ying Qing
China
Vernier Anttila
USA
Maren Lang
Germany
Zoe Robaina
Cuba
Janine Arloth
Germany
Tristram Lett
Germany
Diego Rovaris
Brazil
Zsofia Banlaki
Hungary
Elisabetta Maffioletti
Italy
Lauren Seaman
USA
Cristina Bares
USA
Robert Maier
Australia
Bhagyalakshmi
Shankarappa
India
Caroline Camilo
Brazil
Josiah Masuka
Zimbabwe
Qi Chen
Sweden
Marina Mihaljevic
Serbia
Megan Crow
USA
Eric Monson
USA
Ibene Ekpor
Nigeria
Niamh O’Brien
UK
Sascha Fischer
Switzerland
Søren D. Østergaard
Denmark
Laura Flatau
Germany
Ellen Ovenden
South Africa
Umut Kirli
Turkey
Roseann Peterson
USA
Andrea Vereczkei
Hungary
Chenyao Wang
Japan
Khethelo Xulu
South Africa
Jingjing Zhao
Ireland
Awards
Page 13
Fotis Tsetsos
Greece
AWARDS
ORAL AND POSTER PRESENTATION AWARDS
The Program Committee selected oral and poster presentation finalists from the ECIP
Travel Awardees. The authors will compete for one of three Oral Presentation Awards
or Poster Presentation Awards. Oral and poster presentation award finalists are
notated throughout the program with an ECIP symbol ( ).
ORAL AND POSTER PRESENTATION AWARD FINALISTS:
Muneko Kataoka, Japan
Viviane Labrie, Canada
Tristram Lett, Germany
Robert Maier, Australia
Nina McCarthy, Australia
Eric Monson, USA
Therese Murphy, United Kingdom
Niamh O’Brien, United Kingdom
Harish Ganipaneni Parvathaiah, Ireland
Jennie Pouget, Canada
Nuria Saigi-Morgui, Switzerland
Tarjinder Singh, United Kingdom
Helen Spiers, United Kingdom
Evie Stergiakouli, United Kingdom
Janette Tong, Australia
Yabin Wei, Sweden
Ryan Yuen, Canada
Jingjing Zhao, Ireland
Awards
Abdel Abdellaoui, Netherlands
Ahmed Al Amri, United Kingdom
Bonnie Alberry, Canada
Verneri Anttila, USA
Janita Bralten, Netherlands
Monika Budde, Germany
Qi Chen, Sweden
Megan Crow, USA
Simone de Jong, United Kingdom
Katia de Oliverira, Brazil
Eric Diehl, Canada
Laura Flatau, Germany
Leon French, Canada
Menachem Fromer, USA
Suzi Gage, United Kingdom
Eilis Hannon, United Kingdom
Urs Heilbronner, Germany
Raquel Iniesta, United Kingdom
Page 14
PLENARY SPEAKERS
Plenary Speaker: Nancy J. Cox
Data Integration for Disease Gene Identifications:
Genome x Transcriptome x EMR
October 16, 2015, 4:00 p.m. - 5:00 p.m.
Location: Concert Hall
Nancy J. Cox is a quantitative human geneticist who
has worked for more than 30 years to identify and
characterize the genetic component to common human
diseases and complex traits such as pharmacogenomic
phenotypes. Current research efforts are directed at novel
approaches to integrating large-scale data, including
genomics, transcriptomics, and data from biobanks
and electronic medical records. Dr. Cox earned a BS in
Biology from the University of Notre Dame in 1978, a
Ph.D. in Human Genetics from Yale University in 1982,
and conducted post-doctoral research at Washington
University in psychiatric genetics and the University of
Pennsylvania on the genetics of diabetes before moving
to the University of Chicago in 1987, where she spent
28 years as a faculty member in the Departments of
Medicine and Human Genetics. In 2015, Dr. Cox moved to Vanderbilt University and is
now the Mary Phillips Edmonds Gray Professor of Genetics, and Director of the new
Vanderbilt Genetics Institute, as well as of the Division of Genetic Medicine.
Plenary Speakers
Page 15
PLENARY SPEAKERS
Plenary Session: Thomas Hudson
International Initiatives in Cancer Genomics and Big Data
October 17, 2015, 8:30 a.m. - 9:30 a.m.
Plenary Speakers
Dr. Thomas J. Hudson is President and Scientific
Director of the Ontario Institute for Cancer Research
(OICR), which focuses on translational research in
prevention, detection, diagnosis and treatment of cancer.
Dr. Hudson is internationally renowned for his work
in genomics and human genome variation. At the
Whitehead/MIT Center for Genome Research, he led
a team that generated physical and gene maps of the
human and mouse genomes. Dr. Hudson has been a
founding member of the International Haplotype Map
Consortium, the Public Population Project in Genomics
(P3G) and the International Cancer Genome Consortium.
Dr. Hudson is a member of the Steering Committee of
the Global Alliance for Genomics and Health which is
developing an international framework to allow genetic
and clinical data to be collected, managed and shared in
an effective, responsible, interpretive manner.
Dr. Hudson’s laboratory at OICR is involved in the study of genome variation that
affects cancer predisposition, progression, and response to therapy. His main project
focuses on the genetic architecture of loci associated with risk of colorectal cancer. Dr.
Hudson has co-authored more than 250 peer-reviewed scientific publications.
Dr. Hudson is a Professor in the Departments of Molecular Genetics and Medical
Biophysics at the University of Toronto. He is a fellow of the Royal Society of Canada
and an Officer of the Order of Canada.
Page 16
PLENARY SPEAKERS
Concurrent Plenary Session: Wolfgang Sadee
The Regulome in Psychiatric Therapy: Integrating Chromosomal Architecture
Genetic Variation, Epistasis and Evolution
October 17, 2015, 9:45 a.m. - 10:45 a.m.
Wolfgang Sadee is the Felts Mercer Professor of
Medicine and Pharmacology, Chair, Department of
Pharmacology, College of Medicine, and Director, Center
for Pharmacogenomics, with appointments in Psychiatry,
Pharmacy, and Public Health, the Davis Heart & Lung
Research Institute, and OSU Comprehensive Cancer
Center. With a doctorate degree in Pharmaceutical
Chemistry from the FU Berlin in 1968, he served on the
pharmacy faculties of USC and UCSF until 2002. Dr.
Sadee’s research focuses on pharmacogenomics of drug
response and toxicity, leading the XGEN group at OSU, a
member of the NIH Pharmacogenomics Research Network.
Dr. Sadee has published over 300 research papers and
monographs. He is a founder of Aiko Biotechnology. He
has served as founding editor of Pharmaceutical Research and The AAPS Journal.
He has received several awards, including the Distinguished Scientist Award from the
American Association of Pharmaceutical Scientists.
Plenary Speakers
Page 17
PLENARY SPEAKERS
Concurrent Plenary Session: Lin He
Worldwide Opportunities in Psychiatric Genetic Research
October 17, 2015, 9:45 a.m. - 10:45 a.m.
Plenary Speakers
Dr. Lin He, geneticist, is Fellow of Chinese Academy of
Sciences, Fellow of the World Academy of Sciences for
the advancement of science in developing countries.
He currently works as Professor and Director of Bio-X
Institutes at Shanghai Jiao Tong University, Professor and
Director of the Birth Defects Research Center at Fudan
University, and Professor and Project Leader of Institute
for Nutritional Sciences, Chinese Academy of Sciences,
China, respectively. Dr. He is also advisor for academic
committee of several key laboratories in China. Dr. He
serves as member or associate-editor on the editorial
boards of more than 10 international scientific journals,
such as Experimental Biology and Medicine, Human
Molecular Genetics, Psychiatric Genetics, Human Genetics,
Cell Research, Progress in Neuro-Psychopharmacology
& Biological Psychiatry, Epigenetics, etc. He has been awarded several important
international and national prizes and has had over 400 peer reviewed papers and 17
books published, and more than 20 patents received or to be received. Dr. He is a
leading scientist with one of the most effective teams in the field of neuropsychiatric
genetics or human genetics. Dr. He’s scientific training in genetics includes his M.Sc.
degree at Dongnan University in China, his Ph.D. degree at the University of West
Scotland and his postdoc work at University of Edinburgh in UK across the period of
1983 to 1992. He has worked as a research fellow at the MRC Human Genetics Unit in
Edinburgh for more than three years. Since 1996, Dr. He has entirely moved back with
starting his new career in China.
Page 18
PLENARY SPEAKERS
Concurrent Plenary Session: Bittianda Thelma
October 17, 2015, 9:45 a.m. - 10:45 a.m.
B.K. Thelma is a Professor in the Department of
Genetics at the University of Delhi South Campus,
New Delhi, India. She is the Principal Investigator
and Coordinator of the Centre of Excellence on
Genomes Sciences and Predictive Medicine
funded by the Government of India. She is also
the Coordinator of a major project on newborn
screening for inborn errors of metabolism in Delhi
state which aims to demonstrate the feasibility of
mandatory screening of newborns in the country
and to generate epidemiological data for the
testable IEMs in the genetically distinct Indian
population, for the first time. Discovery genomics
is the major thrust of her research and ongoing
projects include genetic analysis of complex traits including brain and inflammatory
disorders and Mendelian forms of neurological and neuropsychiatric diseases.
Her most recent engagement is in the area of Ayurgenomics wherein homogenous
subgroups of individuals can be identified based on the principles of Ayurveda and
genome analysis including GWAS approaches carried out on these. This approach is
expected to overcome the issue of clinical/phenotypic heterogeneity, which is a major
limitation in contemporary complex trait genetics research.
Page 19
Plenary Speakers
Professor Thelma’s recent academic accomplishments include i) identification of
novel risk genes/loci for two inflammatory conditions namely Rheumatoid arthritis
& Ulcerative colitis by the first ever GWAS conducted in the genetically distinct
north Indian population; ii) discovery of new causal genes namely MID2 for X-linked
Intellectual Disability; PODXL and RIC3 genes for familial Parkinson’s disease by
exome sequencing approach; and iii) demonstration of differences/similarities between
the two major Indian subpopulations namely south and north Indians using both
SNP array based and exome sequencing approaches. She has several national and
international collaborative projects and has over 90 peer reviewed publications to
her credit. She is a fellow of all the three science academies in India, has served as
a member of the Scientific Advisory Council to the Prime Minister of India; National
Science and Engineering Research Board and Human Genetics/Medical Genomics
Task Force of funding agencies including the Department of Biotechnology and Indian
Council of Medical Research, Government of India.
PLENARY SPEAKERS
Concurrent Plenary Session: Homero Vallada
October 17, 2015, 9:45 a.m. - 10:45 a.m.
Plenary Speakers
Homero Vallada is the Director of the Genetics and
Pharmacogenomics Programme at the Institute of
Psychiatry, University of Sao Paulo Medical School
(IPq-USP) in Sao Paulo, Brazil and an Associate
professor from the same institution since 1999.
He received his M.D. from the Sao Paulo Federal
University in 1985, and completed his psychiatric
training at IPq-USP in 1988. Between 1990-1994
he did his research training at the Institute of
Psychiatry (IoP) in London under the supervision
of Robin Murray. He received his Ph.D. degree
(Kings College) in 1995 and was appointed
honorary lecturer at the IoP. In 1996, he returned
to USP and established the first genetic research
group focused on psychiatric disorders in Brazil. He also started collaborations
with research groups within Brazil and abroad. Between 2005 and 2007, he did his
sabbatical at Karolinska Institute in Sweden as part of Martin Schalling’s group. During
the past 20 years, he has authored or co-authored more than 150 scientific reports
and trained Brazilian post-graduate students who later became leaders in their fields.
His more recent area of interest has been in pharmacogenomics, more specifically in
crack/cocaine addiction, including investigation into epigenetic mechanisms.
Page 20
PLENARY SPEAKERS
Concurrent Plenary Session: Humberto Nicolini
October 17, 2015, 9:45 a.m. - 10:45 a.m.
Humberto Nicolini obtained his medical degree from the
UNAM-México, his residency in psychiatry at the Spanish
Hospital in Mexico City. Then he trained in genetics at the
Neuropsychiatric Institute in the University of California
(UCLA). His main contribution was to describe a possible
genetic basis for Obsessive Compulsive Disorder by
segregation analysis. He has published 204 papers
in Spanish and English, and has over 2,000 citations.
February of 2014 he was appointed as a subdirector of
at the National Institute of Genomic Medicine in Mexico
City. Dr. H. Nicolini has ongoing research collaborations
with University of Texas, University Southern California,
Icare4Autism and the CCAMH in Canada. Finally, he is
a member of the Mexican Association for OCD, and a
member and part of the Board of Directors of International Collegue of Obsessive
Compulsive and Spectrum (ICOCS). Also his research has appeared in Nat Geo
“Taboo” Latinoamerica, and in TEDxDF.
Plenary Speakers
Page 21
PLENARY SPEAKERS
Concurrent Plenary Session: Thomas Schulze
October 17, 2015, 9:45 a.m. - 10:45 a.m.
Plenary Speakers
Professor Thomas G. Schulze, born in 1969, studied
medicine in Germany, the USA, and Catalonia. He
trained as a psychiatrist and held positions in Germany
(Bonn, Mannheim, Göttingen) and the USA (Chicago,
Bethesda, Baltimore). Since 2014, he has held the
position of Chair and Director of the Institute of
Psychiatric Phenomics and Genomics at the LudwigMaximilans-University of Munich (IPPG). He is also on
Faculty at Johns Hopkins University’s Department of
Psychiatry. Dr. Schulze’s research focuses on genotypephenotype relationship in psychiatric disorders. He
coordinates a German-wide center grant on longitudinal psychosis research
(www.kfo241.de ; www.PsyCourse.de) and spearheads an international study on the
genetic basis of response to lithium treatment in bipolar disorder (www.ConLiGen.org),
comprising several research groups from Europe, the Americas, Asia, and Australia.
He has authored close to 200 papers. In addition to national German awards, he is
the 2006 recipient of the Robins-Guze Award of the American Psychopathological
Association (APPA) and the 2006 recipient of the Theodore-Reich-Award of the
International Society of Psychiatric Genetics (ISPG). He is a member of the American
College of Neuropsychopharmacology (ACNP) and in 2011 was elected Chair of the
Section on Psychiatric Genetic of the World Psychiatric Association (WPA), of which he
is an Honorary Member. Since 2012, he has held the office of Secretary of the ISPG.
He is currently serving as the President of the APPA.
Page 22
PLENARY SPEAKERS
Plenary Panel Session: Jehannine Austin
Challenges in Genetic Testing and Counseling
October 17, 2015, 4:45 p.m. - 5:45 p.m.
Jehannine Austin completed her Ph.D. in
psychiatric genetics in Cardiff. She is an
Associate Professor in the Departments
of Psychiatry and Medical Genetics at the
University of British Columbia in Vancouver,
Canada and holds the Canada Research Chair
in Translational Psychiatric Genomics. She
is President-Elect of the National Society of
Genetic Counselors and graduate advisor to the
Genetic Counseling Program at the University
of British Columbia. Dr. Austin’s research is
about using psychiatric genetics perspective to
improve outcomes for people with psychiatric
disorders and their families, and in 2012, she
founded the world’s first specialist psychiatric
genetic counseling service of its kind which has already helped over 400 families and
provided training opportunities for 20 clinicians from around the world.
Plenary Speakers
Page 23
PLENARY SPEAKERS
Plenary Panel Session: Francis McMahon
Challenges in Genetic Testing and Counseling
October 17, 2015, 4:45 p.m. - 5:45 p.m.
Plenary Speakers
Dr. McMahon received a B.A. from the University
of Pennsylvania and an M.D. from The Johns
Hopkins University School of Medicine, where he
also completed a residency in adult psychiatry and
a post-doctoral fellowship in genetics. After faculty
appointments at Johns Hopkins and the University
of Chicago, he moved to the National Institute of
Mental Health Intramural Research Program where he
now serves as Chief of the Human Genetics Branch.
He has received awards for his work from NARSAD,
NAMI, NIMH, The Edward F. Mallinckrodt Foundation,
and an NIH Director’s Award for Significant
Achievement. He has authored numerous scientific
reports and textbook chapters. He is a Professor (parttime) at the Johns Hopkins University Department of
Psychiatry, serves on the Editorial Boards of Biological
Psychiatry, Molecular Neuropsychiatry, and Genes,
Brain, & Behavior, and is a scientific advisor for the
American Society for the Prevention of Suicide, the University of Michigan Depression
Center, and the Rutgers University Cell & DNA Repository. Dr. McMahon was elected
to the ISPG Board in 2008, then Vice President in 2010, and President in 2012 and
2014. He also leads the ISPG Genetic Testing Taskforce.
Page 24
PLENARY SPEAKERS
Plenary Session: Jeffrey Liberman
The Notorious Past and Bright Future of Psychiatric Genetics
October 18, 2015, 8:30 a.m. - 9:30 a.m.
Jeffrey Lieberman, M.D., is the Lawrence C. Kolb
Professor and Chairman of the Department of Psychiatry
at Columbia University College of Physicians and
Surgeons; Director of the New York State Psychiatric
Institute; and Psychiatrist-in-Chief at New YorkPresbyterian Hospital – Columbia University Medical
Center. He is also the past President of the American
Psychiatric Association. Over the course of his 30 year career as a physician
and scientist, Dr. Lieberman has studied the nature
and treatment of mental illness and continuously cared
for patients. His work has significantly advanced our
knowledge of the pathophysiology and treatment of
schizophrenia and related psychotic disorders. This
research has fundamentally contributed to our current
standards of care, the development of novel therapeutic
drugs, and the transformative mental healthcare strategy for the early detection and
prevention of schizophrenia. Dr. Lieberman has authored more than 500 papers and articles published in the
scientific literature, and he has written and/or edited 12 books on mental illness and
psychiatry including the critically acclaimed Shrinks: The Untold Story of Psychiatry.
He is the recipient of many honors and awards and in 2000 he was elected to the
National Academy of Sciences Institute of Medicine and fellowship in the American
Association for the Advancement of Science. Plenary Speakers
Page 25
PLENARY SPEAKERS
Plenary Session: Art Petronis
Epigenetics of Psychiatric Disease: Progress, Problems and Perspectives
October 18, 2015, 1:00 p.m. - 2:00 p.m.
Plenary Speakers
Art Petronis graduated from Kaunas Medical University,
Lithuania, and he worked on his Ph.D. at the Brain
Research Institute in Moscow. Dr. Petronis completed
his post-doctoral training at the Clarke Institute of
Psychiatry, Toronto, and since 1997 he has been a
faculty at the Centre for Addiction and Mental Health,
and University of Toronto. Currently, Dr. Petronis is the
Professor and Head of the Krembil Family Epigenetics
Laboratory. He is also Tapscott Chair for Schizophrenia
Studies at the University of Toronto. His research is
dedicated to the elucidation of the role of epigenetic
factors in complex psychiatric diseases such as
Schizophrenia, Bipolar Disorder, and Major Depressive
Disorder. Dr. Petronis published over 100 papers and
book chapters (but only 5 of which are good).
Page 26
PLENARY SPEAKERS
Plenary Session: Zafiris Jeff Daskalakis
Identifying Illness and Treatment Biological Markers through Transcranial
Magnetic Stimulation
October 18, 2015, 6:00 p.m. - 7:00 p.m.
Dr. Zafiris J. Daskalakis was born and raised in Toronto.
He initially started his undergraduate studies at the
University of Toronto and completed medical school at
Queen’s University in 1994. He subsequently entered
the residency training in psychiatry at the University
of Toronto which he completed in 1999. While still a
resident, Dr. Daskalakis began graduate studies in the
Institute of Medical Science at the University of Toronto,
supervised by Drs. Shitij Kapur (Imaging/Psychiatry) and
Robert Chen (Neurophysiology). He completed fellowship
training and his Ph.D. in 2002 at which point he started
as an Assistant Professor at the University of Toronto.
Dr. Daskalakis was promoted to rank of Professor of
Psychiatry in 2013 and is presently the Temerty Chair
in Therapeutic Brain Intervention at CAMH. With an
expertise in the neurophysiology of severe psychiatric
disorders, Dr. Daskalakis’s laboratory uses magnetic brain stimulation to study the
role of cortical inhibition and plasticity as potential pathophysiological mechanisms
in schizophrenia, depression and obsessive compulsive disorder. Dr. Daskalakis also
conducts treatment studies using repetitive transcranial magnetic brain stimulation
(rTMS) and magnetic seizure therapy (MST) for refractory symptoms in these
disorders. He has been a NARSAD Lieber Young Investigator (2004, 2006) a NARSAD
Independent Investigator (2008) and holds or has held CIHR, OMHF and Brain Canada
operating awards. He has also been awarded the Samarthji Lal Award in Mental Health
Research from the Graham Boeckh Foundation. Finally, he has over 200 peer-reviewed
publications, books and book chapters in prestigious journals such as the Archives of
General Psychiatry, Brain and the American Journal of Psychiatry and is an editorial
board member for Biological Psychiatry.
Plenary Speakers
Page 27
PLENARY SPEAKERS
Plenary Session: Douglas Wallace
Plenary Speakers
Mitochondria and their Potential Role in Neuropsychaitric Disorders
October 19, 2015, 8:30 a.m. - 9:30 a.m.
Dr. Wallace has been working on human and
mam-malian mitochondrial genetics for over
40 years. He was the first to demonstrate that
mammalian cells harbored cytoplasmically
inherited genes by inventing the cybrid transfer
technique in the early 1970s and using this
system to demonstrate the cytoplasmic
inheritance of chloramphenicol resistant (CAPR),
a system that he used to further define the rules
of mammalian mitochondrial genetics. This
work culminated in his demonstration of the
maternal inheritance of the human mitochondrial
DNA (mtDNA) in 1980. From this foundation,
his research followed two paths: the quest for
diseases resulting from mutations in the mtDNA
and the investigation of the nature and extent of
human mtDNA variation in aboriginal populations.
The quest for mtDNA diseases culminated in
1988 with the report by Dr. Wallace that Leber Hereditary Optic Neuropathy (LHON)
was caused by a mtDNA missense mutation, the first identified maternally inherited
mtDNA disease. Shortly thereafter he reported the first pathogenic mtDNA tRNA
mutation, the cause of Myoclonic Epilepsy and Ragged Red Fiber Disease (MERRF).
Since that time, Dr. Wallace has shown that mtDNA mutations result in a wide range
of clinical phenotypes but also that somatic mtDNA mutations accumulate in tissues
with age and are central to the aging process and the delayed-onset and progressive
course of neurodegenerative diseases. Wallace’s population studies revealed that
mtDNA variation was unique in that it correlates highly with the ethnic and geographic
origins of indigenous peoples. This ultimately led to the realization that mtDNA
variation was limited by natural selection and that mtDNA variation has been an
important adaptive system for permitting people to survive and multiply in a range
of different human environments. These ancient population lineages (haplogroups)
were then shown to play an important role in predisposition many common “complex”
diseases. To confirm that mitochondrial defects can cause disease, the Wallace lab
was the first to develop mouse models of mitochondrial disease by introducing both
nuclear DNA (nDNA) and mtDNA mutations into the mouse. The method Wallace
invented to insert mutant mtDNAs into the mouse female germline not only resulted
in the geneaiton of mouse models of mtDNA disease but confirmed that mtDNA
mutations were sufficient by themselves produce the common disease phenotypes
supporting the Wallace hypothesis that mitochondrial dysfunction is central to the
etiology of metabolic and degenerative diseases as well as aging and cancer.
Page 28
PLENARY SPEAKERS
Plenary Session: Arvid Carlsson
Dopamine, Schizophrenia, and the Process of Discovery in the Brain Sciences
October 20, 2015, 9:00 a.m. - 10:00 a.m.
Arvid Carlsson, M.D., Ph.D., was awarded the
Nobel Prize in Physiology or Medicine in 2000 for his
fundamental discoveries on dopamine and its role in
Parkinson disease. He was the first to provide evidence
that dopamine was a neurotransmitter, rather than a
precursor to norepinephrine as previously believed.
This in turn laid the groundwork for many others to
understand the role of dopamine in schizophrenia and
psychosis. He was also a pioneer in his work on selective
serotonin reuptake inhibitors and on the action of certain
antipsychotic drugs. Dr. Carlsson is Professor Emeritus at
the University of Gothenburg, Sweden.
Plenary Speakers
Page 29
NOTES
Page 30
SCHEDULE AT A GLANCE
FRIDAY, OCTOBER 16, 2015
8:00 a.m. - 8:30 a.m.
PGC Session: Introduction to the PGC
Tudor 7 & 8
8:05 a.m. - 8:50 a.m.
Education Session: Stem Cells, Neurodevelopment,
and Mental Health
Imperial Room
PGC Session: Analysis of PGC data: The LISA Cluster,
Secondary Analysis Proposals, Data Access
Tudor 7 & 8
8:50 a.m. - 9:35 a.m.
Education Sessions: Ethics Education
Imperial Room
9:00 a.m. - 10:00 a.m.
PGC Session: Ricopili Pipeline – Introduction, QC, PCA
Tudor 7 & 8
9:35 a.m. - 10:20 a.m.
Education Sessions: Polygenic Risk Scoring
Imperial Room
10:15 a.m. - 11:30 a.m.
PGC Session: Ricopili Pipeline – Introduction, QC, PCA
Tudor 7 & 8
10:20 a.m. - 11:05 a.m.
Education Sessions: RDoC
Imperial Room
11:05 a.m. - 11:35 a.m.
Education Sessions: Transcriptomic Studies for ASD
Imperial Room
11:30 a.m. - 12:00 p.m.
PGC Session: PGC3 Plans; Authorship Policy for PGC
Studies
Tudor 7 & 8
11:35 a.m. - 12:00 p.m.
Education Sessions: Splicing/Transcription
Imperial Room
12:00 p.m. - 1:00 p.m.
Lunch (on your own)
1:00 p.m. - 1:30 p.m.
PGC Session: Ricopili Pipeline – Imputation, Analysis
Tudor 7 & 8
1:00 p.m. - 1:40 p.m.
Education Sessions: Imaging Genetics
Imperial Room
8:30 a.m. - 9:00 a.m.
Page 31
1:30 p.m. - 2:00 p.m.
PGC Session: Psych Chip
Tudor 7 & 8
1:40 p.m. - 2:20 p.m.
Education Sessions: Population Neuroscience
Imperial Room
2:00 p.m. - 2:30 p.m.
PGC Session: The Necessity for Robust Analysis and
our Experience
Tudor 7 & 8
Education Sessions: Rodent Models for Psychiatric
Disorders
Imperial Room
2:45 p.m. - 3:45 p.m.
PGC Session: PGC General Meeting
Tudor 7 & 8
2:50 p.m. - 3:20 p.m.
Education Sessions: Fly Models
Imperial Room
3:20 p.m. - 3:50 p.m.
Education Sessions: Fish Models
Imperial Room
3:50 p.m. - 4:00 p.m.
Coffee Break
4:00 p.m. - 5:00 p.m.
Official Congress Opening: Data Integration for
Disease Gene Identification: Genome x Transcriptome
x EMR
Concert Hall
5:00 p.m. - 5:30 p.m.
ECIP Reception (Invitation Only)
Salon B
2:20 p.m. - 2:50 p.m.
5:00 p.m. - 7:00 p.m.
Congress Opening Reception
Ontario
Page 32
FULL SCHEDULE
PGC Sessions
8:00 a.m. - 8:30 a.m.
8:30 a.m. - 9:00 a.m.
Introduction to the PGC
Aiden Corvin, Trinity College Dublin
Tudor 7 & 8
Analysis of PGC Data: The LISA Cluster, Secondary
Analysis Proposals, Data Access
Danielle Posthuma, VU University Amsterdam
Tudor 7 & 8
Ricopili Pipeline – Introduction, QC, PCA
Stephan Ripke and Raymond Walters, The Broad Institute
of Harvard and MIT
Tudor 7 & 8
10:00 a.m. - 10:15 a.m.
Break
10:15 a.m. - 11:30 a.m.
Ricopili Pipeline – Introduction, QC, PCA
of Harvard and MIT
Tudor 7 & 8
9:00 a.m. - 10:00 a.m.
PGC3 Plans; Authorship Policy for PGC Studies
Patrick Sullivan, University of North Carolina; Karolinska
Institutet, Stockholm
Tudor 7 & 8
12:00 p.m. - 1:00 p.m.
Lunch (on your own)
11:30 a.m. - 12:00 p.m.
PGC Sessions
1:00 p.m. - 1:30 p.m.
Ricopili Pipeline – Imputation, Analysis
of Harvard and MIT
Tudor 7 & 8
1:30 p.m. - 2:00 p.m.
Psych Chip
Pamela Sklar, Icahn School of Medicine at Mount Sinai
Tudor 7 & 8
2:00 p.m. - 2:30 p.m.
The Necessity for Robust Analysis and our Experience
Mark Daly, The Broad Institute of Harvard and MIT
Tudor 7 & 8
2:30 p.m. - 2:45 p.m.
Break
2:45 p.m. - 3:45 p.m.
PGC General Meeting
Patrick Sullivan
Tudor 7 & 8
Page 33
FULL SCHEDULE
Education Sessions
8:05 a.m. - 8:50 a.m.
Stem Cells, Neurodevelopment, and Mental Health
David Kaplan, University of Toronto
Imperial Room
8:50 a.m. - 9:35 a.m.
Ethics Education
Jehannine Austin, University of British Columbia
Imperial Room
9:35 a.m. - 10:20 a.m.
Polygenic Risk Scoring
Frank Dudbridge, London School of Hygiene and Tropical
Medicine
Imperial Room
10:20 a.m. - 11:05 a.m.
RDoC
Dost Ongur, Harvard Medical School
Imperial Room
11:05 a.m. - 11:35 a.m.
Transcriptomic Studies for ASD
Mohammed Uddin, Hospital for Sick Children
Imperial Room
11:35 a.m. - 12:00 p.m.
Splicing/Transcription
Hui Yuan Xiong, University of Toronto
Imperial Room
12:00 p.m. - 1:00 p.m.
Lunch (on your own)
Education Sessions
1:00 p.m. - 1:40 p.m.
Imaging Genetics
Jason Lerch, The Hospital for Sick Children
Imperial Room
1:40 p.m. - 2:20 p.m.
Population Neuroscience
Tomas Paus, Child Mind Institute
Imperial Room
2:20 p.m. - 2:50 p.m.
Rodent Models for Psychiatric Disorders
Albert Wong, University of Toronto
Imperial Room
2:50 p.m. - 3:20 p.m.
Fly Models
Marla Sokolowski, University of Toronto
Imperial Room
Page 34
FULL SCHEDULE
3:20 p.m. - 3:50 p.m.
Fish Models
Robert Gerlai, University of Toronto
Imperial Room
3:50 p.m. - 4:00 p.m.
Coffee Break
4:00 p.m. - 5:00 p.m.
Opening Plenary Session: Data Integration for Disease
Gene Identification: Genome x Transcriptome x EMR
Concert Hall
Speaker: Nancy Cox, Vanderbilt University
We have been focused on developing and applying novel integrative methods of
analysis to discover genome variation affecting risk of neuropsychiatric disorders
through studies in BioVU, the 200,000 member biobank at Vanderbilt University.
Although conducting research using electronic health records (EHR) data has its
challenges, being able to assay the consequences of genome variation across the
entire spectrum of EHR phenotypes offers the unique opportunity to learn about
potential pleiotropic effects of genome variation. I will discuss here how we are
working to integrate information on genome variation, genome function and largescale EHR data to improve our understanding of the genetic basis of neuropsychiatric
disorders and will report on some of our initial findings.
5:00 p.m. - 5:30 p.m.
ECIP Reception (Invitation Only)
Salon B
5:00 p.m. - 7:00 p.m.
Opening Reception
Ontario
Page 35
NOTES
Page 36
SATURDAY, OCTOBER 17, 2015
8:30 a.m. - 9:30 a.m.
Plenary Session: International Initiatives in Cancer
Genomics and Big Data
Concert Hall
9:30 a.m. - 9:45 a.m.
Coffee Break
9:45 a.m. - 10:45 a.m.
Concurrent Plenary Sessions
Worldwide Opportunities in Psychiatric The Regulome in Psychaitric
Genetic Research
Therapy: Integrating Chromosomal
Architecture, Genetic Variation,
Epistasis, and Evolution
Ballroom
Concert Hall
10:45 a.m. - 11:00 a.m.
Coffee Break
11:00 a.m. - 12:30 p.m.
Concurrent Oral Presentation Sessions
Bipolar and Mood
Disorders
Schizophrenia:
Pathways, RNA and
CNVs
ADHD/Child Behaviour
Ontario
Ballroom
Tudor 7 & 8
12:30 p.m. - 2:30 p.m.
Poster Sessions
Canadian Room
2:30 p.m. - 4:30 p.m.
Concurrent Symposia Sessions
Polygenic Score
Methodology in
Psychiatric Genetics
Insights into the Genetic
Architecture and
Molecular Markers of
Major Depression from
the CONVERGE Project
Genetic Aspects of
Behavioral Addictions:
New Insights from
Human and Pre-clinical
Models
Tudor 7 & 8
Ballroom
Ontario
4:30 p.m. - 4:45 p.m.
Coffee Break
4:45 p.m. - 5:45 p.m.
Plenary Panel Session: Challenges in Genetic Testing
and Counseling
Concert Hall
7:30 p.m. - 10:00 p.m.
Music and Mental Health Concert
Ballroom
Page 37
NOTES
Page 38
FULL SCHEDULE
8:30 a.m. - 9:30 a.m.
Plenary Session: International Initiatives in Cancer
Geonomics and Big Data
Concert Hall
Speaker: Thomas Hudson, Ontario Institute for Cancer Research
Genomic variation, through its effects on gene structure and expression, plays an
important role in disease predisposition, biology and clinical response to therapy. A
key challenge is to transform this knowledge about genomic variation into clinically
relevant information for tailoring interventions to an individual’s specific genetic,
physical, social and environmental profile. Personalized cancer medicine is based on
rapidly emerging knowledge of the cancer mutation repertoire through comprehensive
studies such as the International Cancer Genome Consortium and the increased
availability of anti-cancer agents that target altered genes or pathways. In my
presentation, I will provide an example of a personalized medicine clinical trial that
screens for actionable tumor mutations in patients with advanced disease in multiple
tumor types. The study demonstrates that rapid sequencing of multi-gene panels is
feasible in a clinical setting and that a subset of patients with metastatic disease that
have exhausted standard therapies can be shown to harbour novel mutations that
offer the potential for clinical response to alternate therapies. As the implementation
of clinical resequencing is rolling out in healthcare organizations, many challenges are
being identified related to the management and interpretation of the data. I will discuss
emerging solutions in data analysis and compute technologies, integration of clinical
sequence datasets with electronic medical records and new models for data sharing
among research and healthcare organizations to enable secure and responsible
sharing of genomic and clinical data, and accelerate the benefits to patients.
9:30 a.m. - 9:45 a.m.
Coffee Break
Concurrent Plenary Sessions: Worldwide
Opportunities in Psychiatric Genetic Research
Ballroom
9:45 a.m. - 10:45 a.m.
Chair: Thomas Schulze, University of Munich
Co-chair: Lin He, Bio-X Institutes, Shanghai Jiao Tong University
BK Thelma, Department of Genetics, University of Delhi South Campus
Homero Vallada, University of Sao Paulo Medical School
Humberto Nicolini, National Institute of Genomic Medicine INMEGEN
Overall Summary: This session is facilitated by ISPG’s Global Diversity Task Force. It
is meant to showcase the scope of psychiatric genetic research beyond the traditional
research strongholds in Australia, Japan, Western Europe and North America. The
speakers will discuss current developments in their respective countries and regions,
the state of post-graduate education in our field, funding situations, the value of
special populations, and opportunities for international collaborations.
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Genetic Leads from Mendelian Forms of Schizophrenia Using Exome Sequencing
BK Thelma, Department of Genetics, University of Delhi South Campus
Multiple approaches ranging from early genome-wide scans through candidate gene
based to genome-wide association studies have been employed in the search for
genetic determinants of Schizophrenia (SZ), a common neuropsychiatric disorder.
Common variants in susceptibility genes/loci on almost all human chromosomes have
been identified but the results have been inconsistent across different ethnic groups.
More recently, using the exome sequencing method and case-parent study design,
several exonic de novo mutations have been reported and these have also been
proposed to explain a part of missing heritability in SZ. Of note, a small proportion
of familial cases are also known to occur which support a major genetic component
in disease etiology. It is hypothesized that using such families with multiple affected
members who are believed to share causal variants more than by chance alone, are a
powerful resource to identify novel disease causing gene(s) as well as to confirm the
pathogenicity of genes with de novo mutations which are being reported in literature.
Using the exome sequencing strategy, ~ 17 families of Indian origin with SZ in at
least two or more members have been analysed. Novel variants including compound
heterozygotes in a few biologically/pharmacologically relevant genes have been found
to segregate with disease in some of the families. These results together with the
possible contribution of these genes to sporadic SZ cohort, which may explain a part
of missing heritability in SZ and also provide some insight in to the elusive biology of
this disorder, would be presented.
Why Do Research in Brazil?
Homero Vallada, University of Sao Paulo Medical School
Since the first Brazilian publications on psychiatric genetics in the 1970’s, there has
been a rapid increase of research in this area in Brazil involving a growing number
of psychiatric phenotypes, using progressively better methodology and more
collaborations with international research groups and participation in global genetic
consortiums. The federal and state governments have also given increased importance
to developing research and channeling more money into science. An example is
the recent initiative Science without Borders that aims to train undergraduate and
graduate students and postdoctoral researchers abroad and improve the critical mass
in the country. Brazil is a large country with more than 200 million people, presenting
a diverse culture and being one of the most heterogeneous populations in the world,
formed mainly by the admixture between European, African and Native American and,
most recently, Asian populations. The population admixture, which is generally much
more extensive than in North America, varies according to regions and history, which
also present some isolated or semi-isolated populations that offer good platforms
for genetic investigation in general and for genetic psychiatric research in particular.
Differences in genetic profile and in the exposure to particular environments may result
in different interactions leading to different psychopathologies. To exemplify the many
strands of psychiatric genetic research in Brazil, molecular genetic investigations into
cocaine/crack addiction will be presented.
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Psychiatric Genetics Research in Latin America: Challenges and Opportunities
Humberto Nicolini, National Institute of Genomic Medicine INMEGEN
Psychiatric genetics is in a time of great discoveries, but most have been described
in Caucasian or of European origin population. There are few results coming from
other populations, including the Latin American. The Latin American population has
several advantages: it is a grouping of 20 countries that predominantly speak the
same language (Spanish), with similar culture background and a fairly homogenous
genetic ancestry. On the other hand, the cost of collecting DNA for research in
these patients is less than carrying out studies in Europe or in the United States and
Canada. It is also important to note that given the proximity to the US, the fastestgrowing minority in this country is from Latin America and there are few studies of
genetic psychiatry itself. We present some of the most significant research carried out
in this region, many of them in collaboration with groups in the US and Europe. There
are some relevant genes found in psychiatric disorders in Latin America, for example,
the gene mapping of Huntington in Maracaibo, Venezuela; Alzheimer in Colombia;
Schizophrenia in Mexico; Bipolar disorder in Costa Rica; and many small studies of
associations with various diseases in many countries, who speak of the potential
of this geographic-cultural region to propose the formation of a Latin American
Consortium of Psychiatrics Genetics Research.
9:45 a.m. - 10:45 a.m.
Concurrent Plenary Sessions: The Regulome in
Psychiatric Therapy: Integrating Chromosomal
Architecture, Genetic Variation, Epistasis, and
Evolution
Concert Hall
Chair: Wolfgang Sadee, The Ohio State University
Large-scale population studies have revealed numerous genes involved in the
pathogenesis of psychiatric disorders; however, our understanding of critical genetic
factors remains incomplete. Recent large-scale genomics studies have advanced
knowledge of functional DNA elements leading to a paradigm shift. More than 80% of
GWAS hits lie outside protein coding exons, regulating transcription and RNA biology;
long-range interactions between genomic DNA elements highlight the importance
of dynamic interactions between gene loci; and variants in enhancer domains
affect the epigenetic machinery and response to the environment – all processes
germane to evolutionary selection. Hence, maintenance of wellness and disease
risk could depend on dynamic gene-gene interactions (epistasis; example DRD2
– DAT interactions) and the integration of entire gene networks – difficult to extract
from GWAS data. In our targeted molecular genetics studies we have searched for
frequent regulatory variants characterized by evolutionary selection pressures, in key
genes likely gating the transition from well-being to disease. Our results show that
genes representing drug targets are enriched with such variants but do not emerge as
strong disease risk genes by themselves, thereby escaping detection by GWAS.
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Search for causative regulatory variants can now be extended genome-wide with the
aid of large databases, including GWAS, ENCODE, and GTEx, overlaying significant
association SNPs, eQTLs, and functional genome annotations. With strong candidate
variants as the starting point, and a much reduced search space, we are now testing
the hypothesis that drug-gene-gene (and network) interactions will prove critical in
determining therapy outcomes. Applying novel mathematical modeling tool, we begin
to tackle dynamic multi-gene-environment (drug) interactions in large clinical studies.
Enabled by the wealth of large data sources emerging at a rapid pace, we can
anticipate that this general approach has the potential to enhance psychiatric therapy
on the basis of personalized medicine. Supported by a grant from the NIH Genera
Medical Sciences U01 GM092655.
10:45 a.m. - 11:00 a.m.
Coffee Break
11:00 a.m. - 12:30 p.m.
ADHD/ Child Behaviour
Tudor 7 & 8
Chair: Anita Thapar, Cardiff University
11:00 a.m. - 11:15 a.m.
11:15 a.m. - 11:30 a.m.
11:30 a.m. - 11:45 a.m.
11:45 a.m. - 12:00 p.m.
12:00 p.m. - 12:15 p.m.
Childhood Maltreatment and Adult Attention Deficit
Hyperactivity Disorder Symptoms: A Twin Study
Andrea Johansson Capusan, Linkoping University,
Sweden
Family Aggregation of Attention Deficit/Hyperactivity
Disorder
Qi Chen, Karolinska Institute
ADHD Risk Loci Identified by Genome-wide
Association Meta-analysis
Ditte Demontis, Aarhus University
Genetic Links Between Social-communication Traits,
ADHD Traits and Clinical ADHD During Development
Beate St Pourcain, University of Bristol
Shared Genetic Effects Between Clinical ADHD and
Smoking, Alcohol and Breastfeeding in Mothers from
the General Population
Evie Stergiakouli, University of Bristol
H = Oral/Poster Finalist
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= ECIP Travel Award
FULL SCHEDULE
12:15 p.m. - 12:30 p.m.
A Hypothesis-driven Genome-wide Association
Study of an Obsessive-Compulsive Quantitative
Trait in a Community-based Sample of Children and
Adolescents
Christie Burton, Hospital for Sick Children
11:00 a.m. - 12:30 p.m.
Bipolar and Mood Disorders
Ontario
Co-Chairs: John Kelsoe, University of California San Diego
Marcella Rietschel, Central Institute of Mental Health
11:00 a.m. - 11:15 a.m.
Stem Cell Models of Bipolar Disorder
Melvin McInnis, University of Michigan
11:15 a.m. - 11:30 a.m.
Bipolar Related Functional Variants in Calcium
Channel Genes
Niamh O’Brien, UCL
11:30 a.m. - 11:45 a.m.
11:45 a.m. - 12:00 p.m.
12:00 p.m. - 12:15 p.m.
12:15 p.m. - 12:30 p.m.
Genome-wide Association Studies and Polygenic
Score Analyses of Suicide Attempt in Mood Disorders
Niamh Mullins, King’s College London
Identification of Shared Risk Loci and Pathways
Between Bipolar Disorder and Schizophrenia
Andreas J. Forstner, University of Bonn
Exome Sequencing of Bipolar Disorder: Family and
Case-control Results Show Overlap with Genes
Implicated in Autism and Schizophrenia
Fernando Goes, Johns Hopkins University
Exploiting SNP Correlations and Prior Information on
the Functional Relevance of Genomic Regions: An
Integrative Analysis of Genetic Risk Factors for Longterm Functional Outcome in Bipolar Disorder
Monika Budde, Institute of Psychiatric Phenomics and
Genomics, Ludwig-Maximilians-University Munich
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= ECIP Travel Award
FULL SCHEDULE
11:00 a.m. - 12:30 p.m.
Schizophrenia: Pathways, RNA and CNVs
Ballroom
Co-Chairs: Michael O’Donovan, Cardiff University
Vishwajit L. Nimgaonkar, University of Pittsburgh
11:00 a.m. - 11:15 a.m.
11:15 a.m. - 11:30 a.m.
11:30 a.m. - 11:45 a.m.
11:45 a.m. - 12:00 p.m.
12:00 p.m. - 12:15 p.m.
12:15 p.m. - 12:30 p.m.
Complex Structural Variation in the MHC Locus
Influences Schizophrenia Risk by Shaping Expression
of Complement Component 4
Aswin Sekar, Harvard Medical School
Common Genetic Variants Indicate a Role of
MicroRNAs in the Etiology of Schizophrenia
Mads Engel Hauberg, Aarhus Univeristy
Investigation of Risk Loci for 18 Autoimmune Diseases
in Schizophrenia Suggests Limited Genetic Overlap
Jennie Pouget, Centre for Addiction and Mental Health
Systematic Pathway Analysis of the Psychiatric
Genomics Consortium Schizophrenia GWAS
Peter Holmans, Cardiff University
New Insights into Schizophrenia Risk from a Genomewide Study of Cnv in 41,321 Subjects
Daniel Howrigan, Post-doctoral
Increased Burden of Genetic Double Hits in
Schizophrenia
Jacob Vorstman, Rudolf Magnus Institute
12:30 p.m. - 2:30 p.m.
Poster Session I
Canadian
*See Pages 81 through 94 for a complete listing of poster
presentations.
= ECIP Travel Award
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FULL SCHEDULE
2:30 p.m. - 4:30 p.m.
Polygenic Score Methodology in Psychiatric Genetics
Tudor 7 & 8
Chair: Paul O’Reilly, King’s College London
Moderator: Naomi Wray, The University of Queensland
2:30 p.m. - 2:35 p.m.
Introduction
Paul O’Reily, King’s College London
2:35 p.m. - 3:00 p.m.
Theory and Applications of Polygenic Risk Scores
Frank Dudbridge, London School of Hygiene and Tropical
Medicine
3:00 p.m. - 3:25 p.m.
Polygenic Risk Score Software (PRSice) and
Increasing the Predictive Power of PRS
Jack Euesden, King’s College London
3:25 p.m. - 3:50 p.m.
Multivariate Polygenic Risk Scores Increases
Accuracy of Risk Prediction for Schizophrenia, Bipolar
Disorder, and Major Depressive Disorder
Robert Maier, University of Queensland
Partitioning Heritability by Functional Category using
GWAS Summary Statistics
Hilary Finucane, Massachusetts Institute of Technology
4:15 p.m. - 4:30 p.m.
Discussion
Gerome Breen, King’s College London
3:50 p.m. - 4:15 p.m.
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= ECIP Travel Award
FULL SCHEDULE
Insights into the Genetic Architecture and Molecular
Markers of Major Depression from the CONVERGE
Project
Ballroom
2:30 p.m. - 4:30 p.m.
Chair: Kenneth Kendler, Virginia Commonwealth University
Moderator: Alexis Edwards, Virginia Institute for Psychiatric and Behavioral Genetics
2:30 p.m. - 2:35 p.m.
Introduction
Kenneth Kendler, Virginia Commonwealth University
2:35 p.m. - 3:00 p.m.
Progress in Understanding the Genetic Architecture of
Major Depression in Han Chinese Women
T. Bernard Bigdeli, Virginia Institute for Psychiatric and
Behavioral Genetics
3:00 p.m. - 3:25 p.m.
3:25 p.m. - 3:50 p.m.
3:50 p.m. - 4:15 p.m.
4:15 p.m. - 4:30 p.m.
Leveraging Gene-mapping by Environmental Risk:
Initial GxE Findings from the CONVERGE Study of
Major Depression
Roseann Peterson, Virginia Commonwealth University
Molecular Signatures of Stress in the CONVERGE
Study of Major Depression
Na Cai, Wellcome Trust Centre for Human Genetics
Association Between the Oral Microbiome and Major
Depression in the CONVERGE Study
Bradley Webb, Virginia Institute for Psychiatric and
Behavioral Genetics
Discussion
Douglas Levinson, Stanford University
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Genetic Aspects of Behavioral Addictions: New
Insights from Human and Pre-clinical Models
Ontario
2:30 p.m. - 4:30 p.m.
Chair: Daniela Lobo, Center for Addiction and Mental Health
Moderator: Vincenzo de Luca, Center for Addiction and Mental Health
2:30 p.m. - 2:35 p.m.
Introduction
Daniela Lobo, Center for Addiction and Mental Health
2:35 p.m. - 3:00 p.m.
Addiction-related Genes in Gambling Disorder
Daniela Lobo, Centre for Addiction and Mental Health
3:00 p.m. - 3:25 p.m.
The Risks of Risky Choice: Modeling Different Aspects
of Gambling-related Cognition in Rats
Michael Barrus, University of British Columbia
3:25 p.m. - 3:50 p.m.
Gene Expression Analyses in an Animal Model of
Problem Gambling
Jose Nobrega, Centre for Addiction and Mental Health
Can Rats Play the Odds? Insight From The Rat
Gambling Task in Modelling Gambling in Rats
Fiona Zeeb, Centre for Addiction and Mental Health
4:15 p.m. - 4:30 p.m.
Discussion
Vincenzo de Luca, Center for Addiction and Mental Health
4:30 p.m. - 4:45 p.m.
Coffee Break
3:50 p.m. - 4:15 p.m.
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4:45 p.m. - 5:45 p.m.
Plenary Panel Session: Challenges in Genetic Testing
and Counseling
Concert Hall
Chair: Francis McMahon, NIH/NIMH
Plenary Speakers: Francis McMahon, NIH/NIMH and Jehannine Austin, University of
British Columbia
Genetic testing in clinical psychiatry raises many questions: Does the current science
support the use of genetic testing for screening, differential diagnosis, or treatment
planning? How can genetic test information be used to inform clinical psychiatry?
How best to answer patients who ask about commercially available genetic testing?
What about secondary findings with health implications that may arise from genomewide assays for copy number variants or exome sequencing? This Plenary Panel will
attempt to address these questions within the context of advances in psychiatric
genetics, new approaches to genetic counselling for mental illness, and current ethical
debates about disclosing genetic information to patients and research participants.
Brief presentations by the panelists will be followed by an extended discussion
session with the audience aimed at framing some of the priorities for future research,
clinical practice, and ethical deliberation.
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7:30 p.m. - 10:00 p.m.
Music and Mental Health Concert
Ballroom
One of the most challenging problems in mental health today is to engage young
people in discussion, prevention, and treatment of psychological distress. If teens and
young adults believe that they are unable to seek help for mental health and addictions
issues, coping with and recovering from experiences such as anxiety, depression and
substance abuse can be even more challenging. Without early intervention, these
issues that arise in younger years may lead to repeated suffering over a person’s
lifetime.
The following proposal is an initiative to engage young people in awareness-building
and stigma-reducing activities in the context of a joyful and entertaining celebration of
rap, hip-hop, dub, and spoken word performance and participation. The first event in
this effort will be held at the Fairmont Royal York Hotel ballroom on Saturday evening,
October 17th. CAMH has secured the venue as part of the global psychiatry and
genetics research conference that Dr. James L. Kennedy is hosting during the 16th 20th of October.
The event supports CAMH’s strategic mandate to build public awareness and drive
social change around mental illness, in the high priority area of youth mental health.
We have a terrific lineup of performers, each of whom is strongly connected to mental
health themes in their repertoire. Dr. Becky Inkster (http://www.neuroscience.cam.ac.uk/
directory/profile.php?Becky.Inkster), faculty member of the Department of Psychiatry
at the University of Cambridge in England, will lead a multimedia (YouTube, DJ)
presentation/workshop on how hip-hop and rap can break down boundaries to
discussion. In spontaneous and natural fashion Dr. Inkster will create participation by
the audience in learning and expressing knowledge and ideas regarding mental health
and psychological resilience. Dr. Akeem Sule (http://www.hiphoppsych.co.uk/
about-us.html), psychiatrist and co-performer with Dr. Inkster, explores in-depth
themes of suffering and success via his performance and audience engagement.
We have the commitment of JUNO award-winning performer and educator Professor
Lillian Allen (http://www.lillianallen.ca), faculty member at Toronto’s OCAD University.
Lillian has extensive experience in both performance art and promotion of learning,
including work with the Ontario Ministry of Health and Long-Term Care. Lillian will
perform selections and provide commentary regarding mental health issues, from her
decades-long career, and backed up by live musicians.
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Page 50
SUNDAY, OCTOBER 18, 2015
7:30 a.m. - 8:30 a.m.
Global Diversity Taskforce (Invitation Only)
Boardroom
8:30 a.m. - 9:30 a.m.
Plenary Session: Where does Mental Illness come
from: Psychiatry’s Greatest Mystery
Concert Hall
9:30 a.m. - 9:45 a.m.
Coffee Break
9:45 a.m. - 11:00 a.m.
ISPG Awardee Presentations with Talks
Concert Hall
11:00 a.m. - 1:00 p.m.
Poster Session II
Canadian Room
1:00 p.m. - 2:00 p.m.
Plenary Session: Epigenetics of Psychiatric Disease:
Progress, Problems and Perspectives
Concert Hall
2:00 p.m. - 2:15 p.m.
Coffee Break
2:15 p.m. - 4:15 p.m.
Dissecting the Genetic
Contribution to
Depression: Progress
at Last
Mitochondria Genetics
and Function in
Psychosis
Sequencing, Directto-consumer-testing,
Biobanking: The
Explosion of Ethical
Challenges in Psychiatric
Genetics, Experiences
from Asia, Europe, and
North America
Tudor 7 & 8
Ballroom
Ontario
4:15 p.m. - 4:30 p.m.
Coffee Break
4:30 p.m. - 6:00 p.m.
Substance Abuse
Genomewide
Approaches in Other
Disorders
Epigenetics and Other
Approaches
Ontario
Ballroom
Tudor 7 & 8
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Plenary Session: Identifying Illness and Treatment
Biological Markers through Transcranial Magnetic
Stimulation
Concert Hall
7:00 p.m. - 8:00 p.m.
2016 Program Committee Meeting (Invitation Only)
Salon A
8:00 p.m. - 10:00 p.m.
Networking Reception (Ticketed Event)
CN Tower
6:00 p.m. - 7:00 p.m.
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7:30 a.m. - 8:30 a.m.
Global Diversity Taskforce (Invitation Only)
Boardroom
8:30 a.m. - 9:30 a.m.
Plenary Session: Where does Mental Illness come
from: Psychiatry’s Greatest Mystery
Concert Hall
Plenary Speaker: Jeffrey Lieberman, New York State Psychiatric Institute/Columbia
University
Psychiatry’s greatest mystery is its most fundamental: Where does mental illness
come from? For over two centuries, we have searched for the answer, often producing
disastrous results and unintended consequences of our mistaken theories. Only
recently have we begun to elucidate the complex puzzle that is the genetic basis of
mental illness, and how to apply this knowledge to the diagnosis and treatment of
affected individuals. Psychiatric genetics had an ignominious beginning with the work
of the British mathematician and social theorist Francis Galton, who conceived the
notorious theory of eugenics. Subsequently, Rudin, Kallman and Kety established a
more heuristic framework using epidemiologic genetics. While their findings clearly
suggested a genetic diathesis for mental illness, they did not conform to known
patterns of inheritance. Mental illnesses frequently skipped entire generations and,
other times, sporadically appeared in families with no other affected members.
Moreover, the population frequencies of illnesses like schizophrenia and autism,
remained relatively constant, or, in some cases, seemed to increase over time, even
though affected persons tended to have low reproductive rates. With the advent
of molecular genetics, scientists scrambled to identify mental illness genes with
all the fervor of miners headed for the Klondike goldrush. But the first report of a
mental illness by Gurling (Nature 1988) proved to be fool’s gold. Others followed with
somewhat greater success identifying common SNPS will low penetrance. In the early
21st century, new powerful sequencing and informatics technologies were introduced,
and the human genome was sequenced.
Then an unexpected breakthrough occurred. Michael Wigler, a cancer biologist
working at Cold Spring Harbor – ironically, the same institution where Charles
Seabrook, the American “father of eugenics” worked – developed a new way of
analyzing genes called ROMA (random oligonucleotide microarray analysis). Instead
of traditional genetic analysis, which examined gene sequences, ROMA determined
the number of copies of a particular gene found in a person’s DNA. Using this
technique researchers discovered that inside any person’s DNA strand, there may
be multiple copies of a particular gene up and down the helix, and the number
of copies is not fixed or pre-determined, and varies from individual to individual.
As researchers painstakingly discovered the myriad mechanisms of genome
expression – exons, introns, promoters, repressors, enhancers, constrainers, factors
(signaling, transcription), mutations (denovo, inherited, somatic) and epigenetics – the
architecture of genetic risk for mental illness began to resemble an elaborate multidimensional genetic slot machine. And while many pieces of the genetic puzzle
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remain to be found, our progress has already established a firm scientific foundation
and enabled us to begin thinking about more precise diagnoses and individualized
treatments. Thus, we can reasonable expect the promise of Precision Medicine
to impact psychiatry, as it has other fields of medicine (especially cancer), in the
foreseeable future. While the ability of mental health professionals to treat various
disorders with custom treatments will increase at a rapid pace as further genetic
discoveries—already in progress—are made, they will also significantly impact the
pernicious and unwarranted stigma historically associated with mental illness.
9:30 a.m. - 9:45 a.m.
Coffee Break
9:45 a.m. - 11:00 a.m.
ISPG Awardee Presentations with Talks
Concert Hall
10:00 a.m. - 10:30 a.m.
Young Investigator Awardee Talk: Using Collaborative
Science to Enhance Neuroimaging Genetics
Sarah Medland, Queensland Institute of Medical Research
Institute
At the individual level, there is substantial variation in brain structure morphology
and brain functions. To identify robust and replicable associations with genetic
variants or psychiatric conditions large well-powered studies are required. Due to the
substantial costs associated with imaging studies collaborative research strategies are
becoming increasingly important. Within the context of the Enhancing Neuro Imaging
Genetics through Meta-Analysis (ENIGMA) Consortium, we conduct collaborative
large-scale genetic analysis of magnetic resonance imaging (MRI) scans. Our work
focuses both on the discovery of genetic variants that exert lasting influences on
brain structure and function and on the identification of disease correlates. Our recent
findings will be discussed focusing on genetic variants influencing the morphology
of subcortical and cortical structures. In addition, we will present the findings from
joint meta-analyses of ICV and Hippocampal volume from 26,577 participants from
the ENIGMA and CHARGE cohorts. We will also present an overview of our metaanalyses looking at case-control differences in brain morphology for Schizophrenia,
Major Depression, Bipolar Disorder and Attention Deficit Hyperactivity Disorder. These
analyses have identified novel variants influencing brain structure and have revealed
substantial overlap between genetic variants influencing hippocampal volume and
those influencing risk for Alzheimer’s disease. Our phenotypic meta-analyses have
also quantified the variation in brain structure associated with common psychiatric
conditions. These studies and the findings they have yielded highlight the importance
of collaboration and cooperation in advancing neuro imaging studies.
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10:30 a.m. - 11:00 a.m.
Lifetime Achievement Awardee Talk: The Nature of
Schizophrenia
Michael Owen, Cardiff University
Recent progress in psychiatric genetics has been unprecedented and nowhere is this
more apparent than for schizophrenia. Recent genomic studies have begun to reveal
its genetic architecture and to give important insights into the nature of the disorder
and its relationship to other psychiatric syndromes. Findings point to a complex and
highly polygenic genetic substrate with contributions from both common and rare
alleles, likely distributed across many hundreds of genes. Consequently, genetic risk
does not map onto the definitions of disease that are used in the clinic. This, along
with the lack of clear boundaries between disorders, suggests that there are likely to
be overlapping mechanisms at work and that current diagnostic categories may not
be optimal for stratifying cases for research into aetiology and pathogenesis. Genomic
findings also converge on epidemiological evidence suggesting that schizophrenia
may be best viewed as one of a range of contiguous and overlapping syndromes
resulting from a disruption of early brain development such as intellectual disability,
autism and ADHD. These findings suggest that it may be fruitful to understand more
about how the developing brain adapts to early adverse events and the impact of
subsequent environmental exposures. Despite the undoubted complexity, and the
fact that much of the genetic risk remains unaccounted for at the DNA level, there are
encouraging signs that the genes implicated in schizophrenia and related syndromes
converge onto sets of plausible biological processes. In particular, recent data point to
abnormalities of synaptic and dendritic function and implicate mechanisms involved in
brain plasticity that are important in development and in learning and cognition. While
these are almost certainly not the only processes involved, they provide robust entry
points for clinical and basic neuroscience research.
11:00 a.m. - 1:00 p.m.
Poster Session II
Canadian
*See Pages 95 through 109 for a complete listing of poster
presentations.
1:00 p.m. - 2:00 p.m.
Plenary Session: Epigenetics of Psychiatric Disease:
Progress, Problems and Perspectives
Concert Hall
Plenary Speaker: Art Petronis, Centre for Addiction and Mental Health, and University
of Toronto
Uncovering the origins of normal and pathological behavior is one of the most difficult
challenges in contemporary biomedical research. There is increasing evidence that, in
addition to DNA sequence and the environment, epigenetic modifications of DNA and
histones may contribute to psychiatric disease. Putative epigenetic misregulation is
consistent with various non-Mendelian irregularities of schizophrenia, bipolar
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disorder, and major depressive disorder. In addition to stochastic, development and/
or environment- induced epigenetic changes, interactions between DNA sequence
variation and epigenetic modifications are of particularly interest in etiopathogenic
studies of major psychiatric disease. I will illustrate this statement by the findings
of our recent study of allele- specific modification of SNPs in the post-mortem
brain samples. Such asymmetrically modified SNPs were significantly enriched in
the schizophrenia GWAS subthreshold SNPs (p<0.1; p<0.01), and they were overrepresented in enhancers, promoters and other functional genomic regions. Additional
support for the synergistic effects of DNA – epigenetic interactions comes from our
epigenetic study of lactose (in) tolerance, a model which exhibits some of the key
features of complex disease: inherited predisposition, delayed age of onset, ethnical
differences, and variable phenotype.
Concurrent Symposia Session
2:15 p.m. - 4:15 p.m.
Mitochondria Genetics and Function in Psychosis
Ballroom
Chair: James L. Kennedy, Centre for Addiction and Mental Health
Moderator: Ana Andreazza, University of Toronto
2:15 p.m. - 2:20 p.m.
Introduction
James L. Kennedy, Centre for Addiction and Mental
Health
2:20 p.m. - 2:45 p.m.
Analysis of Mitochondrial Variants in Schizophrenia
Vanessa Gonçalves, Centre for Addiction and Mental
Health
2:45 p.m. - 3:10 p.m.
Studies of Mitochondria and Schizophrenia
Marquis Vawter, University of California Irvine
3:10 p.m. - 3:35 p.m.
MRI Studies of Brain Bioenergetics in Psychotic
Disorders
Dost Ongur, Harvard Medical School
3:35 p.m. - 4:00 p.m.
4:15 p.m. - 4:30 p.m.
Mitochondrial Multifaceted Dysfunction in
Schizophrenia: Evidence from Molecular, Biochemical
and Cellular Studies
Dorit Ben-Shachar, Rambam Medical Center
Discussion
James L. Kennedy, Centre for Addiction and Mental
Health
Page 56
FULL SCHEDULE
Sequencing, Direct-to-consumer-testing, Biobanking:
The Explosion of Ethical Challenges in Psychiatric
Genetics, Experiences from Asia, Europe, and North
America
Ontario
2:15 p.m. - 4:15 p.m.
Chair: Thomas Schulze, University of Munich
Moderator: Marcella Rietschel, Central Institute of Mental Health
2:15 p.m. - 2:20 p.m.
Introduction
Thomas Schulze, University of Munich
2:20 p.m. - 2:45 p.m.
Ethical Issues Associated with Genetic Counselling in
the Context of Adolescent Psychiatry
Jehannine Austin, University of British Columbia
2:45 p.m. - 3:10 p.m.
3:10 p.m. - 3:35 p.m.
3:35 p.m. - 4:00 p.m.
4:15 p.m. - 4:30 p.m.
Perceptions of Psychiatric Genetic Counselling Within
the UK
Rosa Spencer Tansley, Bournemouth University
The “Right Not to Know”: A Survey of Patients,
Medical Health Care Professionals, and the General
Population
Laura Flatau, University of Munich
Ethical Issues and Data Protection Within the Tohoku
Medical Megabank Project
Fuji Nagami, Tohoku University Tohoku Medical Megabank
Organization
Discussion
Francis McMahon, NIH/NIMH
Page 57
= ECIP Travel Award
FULL SCHEDULE
2:15 p.m. - 4:15 p.m.
Dissecting the Genetic Contribution to Depression:
Progress at Last
Tudor 7 & 8
Chair: Cathryn Lewis, King’s College London
Moderator: Sandra Meier, Center for Register-based Research
2:15 p.m. - 2:20 p.m.
Introduction
Cathryn Lewis, King’s College London
2:20 p.m. - 2:45 p.m.
Genetics of Major Depression: Problems, Hypotheses,
Solutions
Douglas Levinson, Stanford University
2:45 p.m. - 3:10 p.m.
3:10 p.m. - 3:35 p.m.
Mega-analysis of Genome-wide Association Studies in
Major Depressive Disorder: MDD Working Group of the
Psychiatric Genomics Consortium
Cathryn Lewis, King’s College London
Sparse Whole Genome Sequencing Identifies Two Loci
for Major Depressive Disorder in Han Chinese Women
Kenneth Kendler, Virginia Commonwealth University
Using GWAS Summary Statistics to Understand the
Comorbidities of Major Depressive Disorder
Patrick Sullivan, University of North Carolina
4:15 p.m. - 4:30 p.m.
Discussion
Gerome Breen, King’s College London
3:35 p.m. - 4:00 p.m.
Page 58
FULL SCHEDULE
Concurrent Oral Presentations
4:30 p.m. - 6:00 p.m.
Genomewide Approaches in Other Disorders
Ballroom
Co-Chairs: Peggy Richter, Sunnybrook Health Sciences Centre
Co-Chairs: Katharina Domschke, University of Wuerzburg
4:30 p.m. - 4:45 p.m.
4:45 p.m. - 5:00 p.m.
5:00 p.m. - 5:15 p.m.
5:15 p.m. - 5:30 p.m.
5:30 p.m. - 5:45 p.m.
5:45 p.m. - 6:00 p.m.
Genome-wide Association Study (GWAS) of Anxiety
Symptoms in the Hispanic Community Health Study/
Study of Latinos (HCHS/SOL)
Erin Dunn, Harvard Medical School
Increased Mortality among Persons with Anxiety
Disorders and Depression: A Total Population Study
Sandra Meier, Center for Register-based Research
Assessment of Whole-exome Sequence Data in
Attempted Suicide Within a Bipolar Cohort
Eric Monson, University of Iowa
Genome-wide Association Study of Trauma Exposure
in United States Army Soldiers
Chia-Yen Chen, Massachusetts General Hospital
The Role of CHRNA5 in Nicotine Dependence,
Smoking Cessation and Lung Cancer
Laura Bierut, Washington University School of Medicine
Largest GWAS of Anorexia Nervosa Suggests
Significant Loci and Overlap with Obesity-related
Traits
Laramie Duncan, Harvard Medical School
Page 59
= ECIP Travel Award
FULL SCHEDULE
4:30 p.m. - 6:00 p.m.
Epigenetics and Other Approaches
Tudor 7 & 8
Co-Chairs: Jonathan Mill, University of Exeter
Co-Chairs: Zack Kaminsky, Johns Hopkins University
4:30 p.m. - 4:45 p.m.
4:45 p.m. - 5:00 p.m.
5:00 p.m. - 5:15 p.m.
5:15 p.m. - 5:30 p.m.
5:30 p.m. - 5:45 p.m.
5:45 p.m. - 6:00 p.m.
Genome-wide Methylation Analysis in the Brains of
Depressed Suicide Completers
Therese Murphy, University of Exeter
Characterizing Inter-individual Variation in DNA
Methylation Between Blood and Brain: Implications for
Epigenetic Studies of Psychiatric Phenotypes
Eilis Hannon, University of Exeter Medical School,
University of Exeter
Genetic and Epigenetic Factors in Lactose Intolerance:
Lessons for Aging Diseases
Viviane Labrie, Centre for Addiction and Mental Health
CLIP-Cap: Combined Long-insert Paired-end and
Capture Sequencing for Precise and Comprehensive
Analysis of Complex Genomic Rearrangements
Carolin Purmann, Stanford University
Genome-wide Association Studies of Reasoning
Ability, Processing Speed, and Memory in UK Biobank
(N = 112,151)
Gail Davies, The University of Edinburgh
A Meta-analysis of >16,000 Exomes Reveals a
Dominant, Highly Penetrant Subtype of Schizophrenia
Comorbid with Intellectual Disability
Tarjinder Singh, Wellcome Trust Sanger Institute
= ECIP Travel Award
Page 60
FULL SCHEDULE
4:30 p.m. - 6:00 p.m.
Substance Abuse
Ontario
Co-Chairs: Vincenzo DeLuca, Centre for Addiction and Mental Health
Co-Chairs: Gerome Breen, King’s College London
4:30 p.m. - 4:45 p.m.
4:45 p.m. - 5:00 p.m.
5:00 p.m. - 5:15 p.m.
5:15 p.m. - 5:30 p.m.
5:30 p.m. - 5:45 p.m.
5:45 p.m. - 6:00 p.m.
Assessing Fetal Alcohol Spectrum Disorder Etiology
via Hippocampal Gene Expression Following
Continuous Prenatal Alcohol Exposure and Postnatal
Maternal Separation in Mice
Bonnie Alberry, University of Western Ontario
Whole Genome Sequence Analysis of Cannabis
Dependence Across Two Independent Cohorts
Ian Gizer, University of Missouri-Columbia
Genome-wide SNP Heritability of Multiple Indices of
Nicotine Dependence
Cinnamon Bidwell, University of Colorado
Oxidative Stress Pathways Implicated in
Comprehensive Epigenetic and Transcriptomic
Assessment of Hippocampus in a Model of Fetal
Alcohol Spectrum Disorders
Eric Diehl, University of Western Ontario
Using Biomarkers of Tobacco Exposure in Genomewide Association Studies
Jennifer Ware, University of Bristol
Modeling Tobacco Exposures Including the Role of
Nicotine Metabolic Enzymes
Andrew Bergen, SRI International
Page 61
= ECIP Travel Award
FULL SCHEDULE
6:00 p.m. - 7:00 p.m.
Plenary Session: Identifying Illness and Treatment
Biological Markers Through Transcranial Magnetic
Stimulation
Concert Hall
Plenary Speaker: Zafiris Daskalakis, Centre for Addiction and Mental Health
Transcranial Magnetic Stimulation (TMS) results in depolarization of neurons through a
magnetic field applied over the scalp. TMS can be used as both as a neurophysiologic
and treatment tool in psychiatric and neurologic disorders. As a neurophysiological
tool, TMS can be used to probe key neuronal processes including inhibition and
plasticity. As a treatment tool, TMS is applied repetitively (i.e., rTMS) to produce
its therapeutic effects. rTMS has shown efficacy in a number of psychiatric and
neurological disorders including depression, Parkinson’s disease and schizophrenia.
Some of the therapeutic mechanisms through which rTMS exerts efficacy in these
disorders includes those same mechanisms that can be probed through TMS
(i.e., inhibition and plasticity). For example, rTMS is effective in treatment resistant
depression. Dysfunctional inhibition and plasticity – mediated largely by GABA
and NMDA – have been postulated as mechanisms underlying treatment resistant
depression. TMS combined with EMG or EEG represents a unique experimental
modality used to directly index inhibition and plasticity in the motor and prefrontal
cortex. Data will be presented linking rTMS to changes in inhibition and plasticity in
depression. These changes may be used to better optimize rTMS therapeutic effects.
Data will also be presented linking other forms of brain stimulation (i.e., deep brain
stimulation and magnetic seizure therapy) to inhibition and plasticity in the prefrontal
cortex in depression. Such findings will be expanded and discussed in relation to their
potential as biomarkers for predicting treatment response to novel brain stimulation
therapies.
7:00 p.m. - 8:00 p.m.
2016 Program Committee Meeting (Invitation Only)
Salon A
8:00 p.m. - 10:00 p.m.
Networking Reception (Ticketed Event)
CN Tower
Page 62
MONDAY, OCTOBER 19, 2015
7:30 a.m. - 8:30 a.m.
“Ask the Editor”
Tudor 7 & 8
8:30 a.m. - 9:30 a.m.
Plenary Session: Mitochondria and their Potential Role
in Neuropsychiatric Disorders
Concert Hall
9:30 a.m. - 9:45 a.m.
Coffee Break
9:45 a.m. - 11:45 a.m.
Current Approaches
to Genetic/Genomic
Studies on Alcoholism
Genetic Architecture
Insights from Joint
Investigations of Rare
CNVs and Common
SNPs
The Genetic Dissection
of Bipolar Disorder: From
Common to Rare Risk
Variation
Tudor 7 & 8
Ballroom
Ontario
11:45 a.m. - 1:00 p.m.
ISPG Business Meeting with Lunch
1:00 p.m. - 2:30 p.m.
Advances in Autism
Schizophrenia
Neuroimaging and
Alternate Phenotyples
Ontario
Ballroom
Tudor 7 & 8
2:30 p.m. - 2:45 p.m.
Coffee Break
2:45 p.m. - 4:45 p.m.
Genetics of Comorbidity
Between Substance Use
Disorders and Other
Severe Mental Illness
Tracking the Descent to
Mental Illness – Insights
into the Trajectory to
Illness from Studies of
Youth at High Risk of
Bipolar Disorder
Genetics of Research
Domain Criteria (RDoC)
Tudor 7 & 8
Ballroom
Ontario
4:45 p.m. - 6:45 p.m.
Poster Session III
Canadian
6:45 p.m. - 8:30 p.m.
ISPG Board Meeting (Invitation Only)
Salon A
Page 63
NOTES
Page 64
FULL SCHEDULE
7:30 a.m. - 8:30 a.m.
“Ask the Editor”
Tudor 7 & 8
8:30 a.m. - 9:30 a.m.
Plenary Session: Dopamine, Schizophrenia, and the
Process of Discovery in Brain Sciences
Concert Hall
Plenary Speaker: Douglas Wallace, Children’s Hospital of Philadelphia
In spite of prodigious efforts to identify nuclear DNA (nDNA) genetic and neuroanatomical
variants associated with neuropsychiatric diseases, the pathophysiology of these
disorders remains unclear. Since the brain is 2% of the body weight yet uses 20% of
the oxygen, it follows that subtle reductions in mitochondrial oxidative phosphorylation
(OXPHOS) should have marked effects on the brain. The mitochondrion is assembled
from between one to two thousand nDNA coded mitochondrial genes plus 13 of the
most important OXPHOS genes which are coded in the mitochondrial DNA (mtDNA),
the mtDNA also harboring the tRNAs and rRNAs for the expression of the mtDNA
polypeptides. The mtDNA is maternally inherited, present in thousands of copies
per cell, and can encompass different percentages of mutant and normal mtDNAs
(heteroplasmy) generating variable OXPHOS defects and clinical phenotypes. As the
proportion of mutant mtDNA heteroplasmy increases, bioenergetic function declines,
and the mitochondria signal to the nucleus-cytosol the changing energetic state
through mitochondrially-generated high energy intermediates (ATP, acetyl-CoA, Sadenosylmethionine, α-ketoglutarate, etc.). This induces changes in the epigenome
which precipitate phase changes in gene expression, produce discrete bioenergeic
states and cellular and clinical phenotypes, the mildest mitochondrial defects causing
neuropsychiatric disorders. There are three clinically relevant classes of mtDNA variants:
ancient mtDNA lineages (haplogroups), recent deleterious mutations, and somatic
mutations. Case control studies have identified mtDNA haplogroup lineages associated
with predisposition to various neurological diseases including autism, Alzhiemer Disease,
and Parkinson Disease. Maternally inherited deleterious mtDNA mutations have been
linked to other neurological diseases including Leber Hereditary Optic Neuropathy
(LHON) and myoclonic epilepsy. Somatic mtDNA mutation levels are elevated in multiple
neurological disorders. The generation of mice which harbor mutations in both nDNA and
mtDNA coded mitochondrial genes have been found to generate neurological disease.
Creation of a mouse harboring the human pathogenic mtDNA ND6 P25L mutation
resulted in neurodegenerative diseases and excessive mitochondrial reactive oxygen
species (ROS) production. Simply mixing two different normal mtDNAs within the mouse
female germline resulted in reduced activity, hyper-excitability, and a severe learning
defect. Mutation of the brain-heart-muscle isoform of the adenine nucleotide translocator
(ANT1) resulted in impaired fetal cortical interneuron migration causing chronic
cortical excitation and autism-like behavior. Mice harboring various nDNA and mtDNA
mitochondrial gene mutations and exposed to acute stress manifest marked differences
in the hypothalamic-pituitary-adrenal (HPA) and sympathetic adrenal-medullary (SAM)
axis, catecholamine levels, metabolites, and inflammatory cytokines. Hence, individual
differences in mitochondrial function may be the basis for differential predilection to
neuropsychiatric diseases and response to stress suggesting that partial mitochondrial
defects may underlie the pathophysiology of multiple neuropsychiatric disorders.
Page 65
FULL SCHEDULE
Genetic Architecture Insights from Joint Investigations
of Rare CNVs and Common SNPs
Ballroom
9:45 a.m. - 11:45 a.m.
Chair: Sarah Bergen, Karolinska Institute
Moderator: Patrick Sullivan, Karolinska Institute and University of North Carolina,
Chapel Hill
9:45 a.m. - 9:50 a.m.
Introduction
Sarah Bergen, Karolinska Institute
9:50 a.m. - 10:15 a.m.
Characterizing an Inverse Axis Between Orthogonal
Sources of Genetic Risk
Lea Davis, The University of Chicago
10:15 a.m. - 10:40 a.m.
10:40 a.m. - 11:05 a.m.
On the Prediction of Risk for Autism from Common
Variants
Lingxue Zhu, Carnegie Mellon University
Genetic Risk for Psychiatric Disorders and
Reproductive Fitness in the General Population
Niamh Mullins, King’s College London
CNVs and SNPs Additively Contribute to Schizophrenia
Risk
Sarah Bergen, Karolinska Institute
11:30 a.m. - 11:45 a.m.
Discussion
Naomi Wray, The University of Queensland
11:05 a.m. - 11:30 a.m.
Page 66
FULL SCHEDULE
9:45 a.m. - 11:45 a.m.
Current Approaches to Genetic/Genomic Studies on
Alcoholism
Tudor 7 & 8
Chair: R. Dayne Mayfield, University of Texas at Austin
Moderator: Abbas Parsian, National Institute of Health/NIAA
9:45 a.m. - 9:50 a.m.
Introduction
R. Dayne Mayfield, University of Texas at Austin
9:50 a.m. - 10:15 a.m.
Genomics of Alcoholism – GWAS and Beyond
Howard Edenberg, Indiana University School of Medicine
10:15 a.m. - 10:40 a.m.
Neurogenomic Networks Involved in Alcohol Use
Disorders
Sean Farris, University of Texas at Austin
10:40 a.m. - 11:05 a.m.
Adolescent Alcohol Exposure and Epigenetic
Mechanisms: A Role in Anxiety and Alcoholism in
Adulthood
Subhash Pandey, University of Illinois at Chicago
A Systems Biology Approach to the Genetic Study of
Alcohol Dependence
Shizhong Han, University of Iowa
11:30 a.m. - 11:45 a.m.
Discussion
Abbas Parsian, National Institute of Health/NIAA
11:05 a.m. - 11:30 a.m.
Page 67
FULL SCHEDULE
The Genetic Dissection of Bipolar Disorder: From
Common to Rare Risk Variation
Ontario
9:45 a.m. - 11:45 a.m.
Chair: Peter Zandi, Johns Hopkins University
Moderator: John Kelsoe, University of California San Diego
9:45 a.m. - 9:50 a.m.
Introduction
Peter Zandi, Johns Hopkins University
9:50 a.m. - 10:15 a.m.
Genome-wide Association Study Meta-analysis of
Thirty-two Cohorts Totaling 20,352 Cases and 31,358
Controls Identifies Twelve New Bipolar Disorder Loci
Eli Stahl, Icahn School of Medicine at Mount Sinai
10:15 a.m. - 10:40 a.m.
10:40 a.m. - 11:05 a.m.
Genome-wide Association Study using Psychchip in a
Cohort of >13,000 New Bipolar Disorder Cases
Pamela Sklar, Icahn School of Medicine at Mount Sinai
Exomal Analysis of 3531 Bipolar Disorder Cases and
4774 Controls
Laura Scott, University of Michigan Medical School
Meta-analysis of Family Sequencing Studies from the
Bipolar Sequencing Consortium
Seth Ament, Institute for Systems Biology
11:30 a.m. - 11:45 a.m.
Discussion
Francis McMahon, NIH/NIMH
11:45 a.m. - 1:00 p.m.
ISPG Business Meeting with Lunch
Concert Hall
11:05 a.m. - 11:30 a.m.
Page 68
FULL SCHEDULE
1:00 p.m. - 2:30 p.m.
Advances in Autism
Ontario
Co-Chairs: John Vincent, Center for Addiction and Mental Health
Jim Sutcliffe, Vanderbilt University
1:00 p.m. - 1:15 p.m.
Results from the Largest GWAS of Autism to Date
Jakob Grove, Aarhus University
1:15 p.m. - 1:30 p.m.
Genetic Risk for Autism Spectrum Disorders and
Neuropsychiatric Variation in the General Population
Elise Robinson, Massachusetts General Hospital
1:30 p.m. - 1:45 p.m.
1:45 p.m. - 2:00 p.m.
2:00 p.m. - 2:15 p.m.
2:15 p.m. - 2:30 p.m.
One in Three De Novo Variants Seen in Autism
Spectrum Disorder Probands are Present as Standing
Variation in a Cohort of More than 60,000 Non-ASD
Individuals
Jack Kosmicki, Harvard University
Genome-wide Association Study Identifies Novel Loci
for Autistic Traits in the General Population
Janita Bralten, Radboud University Nijmegen Medical
Centre
Genome-wide De Novo Mutation Landscape in Autism
Spectrum Disorder
Ryan Yuen, The Centre for Applied Genomics
Variants in CACNA1C are Associated with Sleep
Regulation in Infants
Katri Kantojärvi, Public Health Genomics Unit, National
Institute for Health and Welfare, Helsinki, Finland
= ECIP Travel Award
Page 69
FULL SCHEDULE
1:00 p.m. - 2:30 p.m.
Neuroimaging and Alternate Phenotyples
Tudor 7 & 8
Chair: Aristotle Voineskos, University of Toronto
1:00 p.m. - 1:15 p.m.
1:15 p.m. - 1:30 p.m.
1:30 p.m. - 1:45 p.m.
1:45 p.m. - 2:00 p.m.
2:00 p.m. - 2:15 p.m.
2:15 p.m. - 2:30 p.m.
Overlapping Genetic Variants Mediate Risk for OCD
and the Volumes of the Nucleus Accumbens and
Putamen
Derrek Hibar, University of Southern California
ENIGMA CNV Working Group: Coupling Subcortical
Brain Volumes with CNVs in Healthy and Patient
Populations
Ida Sonderby, NORMENT, KG Jebsen Centre for
Psychosis Research, Oslo
Interaction of the INPP5K Gene and Serum Uric Acid
Predict Nigrostriatal Degeneration in Parkinson’s
disease: A Genome-wide Interaction Study
Arash Nazeri, Centre for Addiction and Mental Health
Genetic Interaction Regulates Isoform-specific
Expression of an Alzheimer’s Disease Risk Gene and
Affects Brain Structural Connectivity
Daniel Felsky, Centre for Addiction and Mental Health
Fifty Years of Twin Studies on Psychiatric Traits Show
that for the Majority of Traits Genetic Variation is
Mostly Additive
Danielle Posthuma, VU University
GWAS-based Machine Learning Approach to Predict
Duloxetine Response in Major Depressive Disorder
Malgorzata Maciukiewicz, Centre for Addiction and Mental
Health
Page 70
FULL SCHEDULE
1:00 p.m. - 2:30 p.m.
Schizophrenia
Ballroom
Chair: Jordan Smoller, Harvard Medical School
1:00 p.m. - 1:15 p.m.
1:15 p.m. - 1:30 p.m.
1:30 p.m. - 1:45 p.m.
1:45 p.m. - 2:00 p.m.
2:00 p.m. - 2:15 p.m.
Genome-wide Associated Variants of Schizophrenia
and Bipolar Disorder Linked with Splicing Motifs and
Gene Expression
Jonathan Hess, SUNY Upstate Medical University
Clinical and Genetic Re-evaluation of the Scottish
DISC1 Translocation Family
Pippa Thomson, Institute of Genetics and Molecular
Medicine
Clinically Relevant Genetic Variants: Models
for Understanding Schizophrenia and Other
Neuropsychiatric Disorders Duplications at 15q11-Q13
in Schizophrenia and Neurodevelopmental Disorders
George Kirov, Cardiff University
RNA-sequencing of Multiple Cortical Regions from
>500 Brains of Schizophrenia Patients and Controls
Implicates Genes Overlapping Genetic Associations
and Elucidates Genetic Risk
Menachem Fromer, Icahn School of Medicine at Mount
Sinai
Genic Intolerance to Copy Number Variation in 60,000
Individuals and Applications to Identifying Risk Genes
in Schizophrenia
Douglas Ruderfer, MSSM
Polygenic Risk Score in a Sample of First Episode
Psychosis Discriminates Schizophrenia from other
Psychoses
Evangelos Vassos, King’s College London
2:30 p.m. - 2:45 p.m.
Coffee Break
2:15 p.m. - 2:30 p.m.
= ECIP Travel Award
Page 71
FULL SCHEDULE
Tracking the Descent to Mental Illness – Insights into
the Trajectory to Illness from Studies of Youth at High
Risk of Bipolar Disorder
Ballroom
2:45 p.m. - 4:45 p.m.
Chair: John Nurnberger, Indiana University School of Medicine
Moderator: Melvin McInnis, University of Michigan
2:45 p.m. - 2:50 p.m.
Introduction
John Nurnberger, Indiana University School of Medicine
2:50 p.m. - 3:15 p.m.
Developmental Antecedents to Major Mood
Disorders and Sex-specific Parent of Origin Effects in
Transgenerational Transmission of Psychopathology
Rudolf Uher, Dalhousie University
3:15 p.m. - 3:40 p.m.
3:40 p.m. - 4:05 p.m.
Clinical Subtyping of Bipolar Disorder: Prediction of
Risk and Course of Illness
John Nurnberger, Indiana University School of Medicine
Neurodevelopmental Trajectories in Young People at
High Familial Risk for Bipolar Disorder
Janice Fullerton, Neuroscience Research Australia
Imaging Predictors of the Onset of Mood Disorders in
People at High Genetic Risk
Andrew McIntosh, University of Edinburgh
4:30 p.m. - 4:45 p.m.
Discussion
Philip Mitchell, University of New South Wales
4:05 p.m. - 4:30 p.m.
Page 72
FULL SCHEDULE
2:45 p.m. - 4:45 p.m.
Genetics of Comorbidity Between Substance Use
Disorders and Other Severe Mental Illness
Tudor 7 & 8
Chair: Sarah Hartz, Washington University in Saint Louis
Moderator: Laura Bierut, Washington University School of Medicine
2:45 p.m. - 2:55 p.m.
Introduction
Sarah Hartz, Washington University in Saint Louis
2:55 p.m. - 3:25 p.m.
Investigations of Substance Use Disorders in
Pedigrees Ascertained for Severe Bipolar Disorder
(BP-I)
Nelson Freimer, University of California Los Angeles
3:25 p.m. - 3:55 p.m.
Phenotypic and Genetic Characterization of
Comorbidity Between Substance Use and
Schizophrenia
Sarah Hartz, Washington University in Saint Louis
Problematic Alcohol Use Behavior Comorbidity in
a Highly Traumatized Urban Cohort and its GWAS
Association with an EQTL of the SCLT1 Gene
Kerry Ressler, McLean Hospital
4:25 p.m. - 4:45 p.m.
Discussion
Philip Mitchell, University of New South Wales
3:55 p.m. - 4:25 p.m.
Page 73
FULL SCHEDULE
2:45 p.m. - 4:45 p.m.
Genetics of Research Domain Criteria (RDoC)
Ontario
Chair: Stephen Faraone, SUNY Upstate Medical University
Moderator: Stephen Glatt, SUNY Upstate Medical University
2:45 p.m. - 2:55 p.m.
Introduction
Stephen Faraone, SUNY Upstate Medical University
2:50 p.m. - 3:15 p.m.
Translational and Research Domain Criteria (RDoC)
Perspectives on the Genetics of Trauma-related
Psychiatric Disorders
Joan Kaufman, Yale University
The Dimensionality and Heritability of Obsessivecompulsive Features in a Community Sample of
Children and Adolescents
Paul Arnold, University of Calgary
3:40 p.m. - 4:05 p.m.
Genetics of Aggression
Yanli Zhang-James, SUNY Upstate Medical University
4:05 p.m. - 4:30 p.m.
Reconceptualising “Language“ Within a RDoC
Framework
Kristin Nicodemus, University of Edinburgh
4:25 p.m. - 4:45 p.m.
Discussion
Sarah Morris, NIMH
3:15 p.m. - 3:40 p.m.
4:45 p.m. - 6:45 p.m.
Poster Session III
Canadian
*See Pages 110 through 123 for a complete listing of
poster presentations.
6:45 p.m. - 8:30 p.m.
ISPG Board Meeting (Invitation Only)
Salon A
Page 74
TUESDAY, OCTOBER 20, 2015
8:00 a.m. - 9:00 a.m.
ISPG Genetic Testing Taskforce Meeting
(Invitation Only)
Salon A
Process of Discovery in the Brain Sciences
Concert Hall
10:00 a.m. - 10:15 a.m.
Coffee Break
10:15 a.m. - 11:45 a.m.
9:00 a.m. - 10:00 a.m.
Pharmacogenetics of
Response and Side
Effects
Dissecting the
Schizophrenia
Phenotype
Biostatistics and
Bioinformatics
Ontario
Ballroom
Tudor 7 & 8
11:45 a.m. - 12:00 p.m.
Closing Remarks/Congress Adjourns
Page 75
NOTES
Page 76
FULL SCHEDULE
8:00 a.m. - 9:00 a.m.
Genetic Testing Taskforce Meeting (Invitation Only)
Salon A
9:00 a.m. - 10:00 a.m.
Process of Discovery in the Brain Sciences
Concert Hall
Plenary Speaker: Arvid Carlsson, Nobel Laureate
Professor Carlsson will first describe his scientific career development in the 1950s
and his early experiments that led to his discovery of dopamine as an important
neurotransmitter. He will comment on the challenges facing scientists early in their
careers, particularly the skepticism that is frequently encountered when challenging
the scientific opinions of the time. He will comment on his decades of work on
dopamine neurotransmission, leading up to his current work on drug discovery for
new compounds that stabilize dopaminergic activity. One such compound, OSU6162,
is in clinical trials by Professor Carlsson and colleagues for treatment of Huntington’s
Disease (Kloberg et al., 2014). The compound has been shown to bind a subset of D2/
D3 receptors as measured by PET ligand binding (Tolboom et al., 2015). Professor
Carlsson will also summarize a framework for studying the brain that extends from an
approach delineated in his Nobel speech in the year 2000.
10:00 a.m. - 10:15 a.m.
Coffee Break
Page 77
FULL SCHEDULE
10:15 a.m. - 11:45 a.m.
Dissecting the Schizophrenia Phenotype
Ballroom
Co-Chairs: Robin Murray, Institute of Psychiatry, King’s College London
Stephan Ripke, MGH
10:15 a.m. - 10:30 a.m.
10:30 a.m. - 10:45 a.m.
10:45 a.m. - 11:00 a.m.
11:00 a.m. - 11:15 a.m.
11:15 a.m. - 11:30 a.m.
11:30 a.m. - 11:45 a.m.
The Emerging Landscape of Schizophrenia Risk
Conferred by De Novo Coding Mutations
Daniel Howrigan, Massachusetts General Hospital
Structural Connectivity and Cortical Inhibition at the
Dorsolateral Prefrontal Cortex Mediate the Association
Between GAD1 and Working Memory Dysfunction
Relevant to Schizophrenia
Tristram Lett, Charite University Hospital
The European Union Gene Environment Interaction
(EUGEI) Dataset – A Pan-European Psychosis Cohort
with Phenotype and Environment Data and Common
and Rare Genotypes
Alexander Richards, Cardiff University
Evidence for the Involvement of DFNB31 Variants in
Psychotic Disorders
Ahmed Al Amri, University of Leeds
Rare Disruptive Mutations in Constrained Genes in a
Swedish Schizophrenia Case-control Cohort
Giulio Genovese, Broad Institute
Genome-wide Methylomic Analysis of Monozygotic
Twins Discordant for Schizophrenia
Emma Dempster, University of Exeter
Page 78
= ECIP Travel Award
FULL SCHEDULE
10:15 a.m. - 11:45 a.m.
Biostatistics and Bioinformatics
Tudor 7 & 8
Chair: Benjamin Neale, Massachusetts General Hospital
10:15 a.m. - 10:30 a.m.
10:30 a.m. - 10:45 a.m.
10:45 a.m. - 11:00 a.m.
11:00 a.m. - 11:15 a.m.
11:15 a.m. - 11:30 a.m.
11:30 a.m. - 11:45 a.m.
Using Single Cell RNA-Seq to Explore Cell-type
Specific Co-expression of Neuropsychiatric Disease
Genes
Megan Crow, Cold Spring Harbor Laboratory
Integrating Genome-wide Meta-analyses of Binary and
Continuous Phenotypes
Raymond Walters, Massachusetts General Hospital/Broad
Institute
The Statistical Properties of Gene-set Analysis for
GWAS Data
Christiaan de Leeuw, Vrije Universiteit
Cross-disorder Heritability Analysis of 23 Brain
Diseases Reveals Novel Patterns of Shared Genetic
Background Between Psychiatric and Neurological
Diseases
Verneri Anttila, Massachusetts General Hospital
Multivariate Genetic Risk Scores Increase Accuracy
of Risk Prediction for Schizophrenia, Bipolar Disorder,
and Major Depressive Disorder
Robert Maier, University of Queensland
SAPLING: A Tool for Customized Network Analysis
Focusing on Psychiatric Genetics
Wim Verleyen, Cold Sping Harbor Laboratory
Page 79
= ECIP Travel Award
FULL SCHEDULE
10:15 a.m. - 11:45 a.m.
Pharmacogenetics of Response and Side Effects
Ontario
Chair: Dan Rujescu, University of Halle
10:15 a.m. - 10:30 a.m.
10:30 a.m. - 10:45 a.m.
10:45 a.m. - 11:00 a.m.
11:00 a.m. - 11:15 a.m.
11:15 a.m. - 11:30 a.m.
Complex Genetic Overlap Between Schizophrenia Risk
and Antipsychotic Response
Douglas Ruderfer, MSSM
Combining Clinical and Genetic Variables to Predict
Antidepressant Treatment Response: A Machine
Learning Approach
Raquel Iniesta, MRC Social Genetic and Developmental
Psychiatry Center, Institute of Psychiatry, King’s College
London, London
Association of Orexin Receptor Polymorphisms with
Antipsychotic-induced Weight Gain
Arun Tiwari, Centre for Addiction and Mental Health
Comprehensive Genetic Analysis Implicates Novel
Mechanisms for Clozapine-associated Neutropenia
Sophie Legge, Cardiff University
Moving Beyond Depression Rating Scores in
Antidepressant Genome-wide Association Studies:
The Pharmacogenomics of Weight Change During
Antidepressant Treatment
Joanna Biernacka, Mayo Clinic
Pharmacogenetics of Antipsychotics in Never-treated
Patients
Todd Lencz, Zucker Hillside Hospital
11:45 a.m. - 12:00 p.m.
Closing Remarks/Congress Adjourns
11:30 a.m. - 11:45 a.m.
= ECIP Travel Award
Page 80
POSTERS
ADHD
Sex-specific Common Genetic Variant Analyses of Attention Deficit
Hyperactivity Disorder
Joanna Martin, Stephen Faraone, Raymond Walters, Barbara Franke, Psychiatric
Genomics Consortium: ADHD Subgroup, iPSYCH-SSI-Broad ADHD Workgroup, Anita
Thapar, Benjamin Neale
Sa1.
First Results from the CensusADHD Study: Large-scale Medication Based
Recruitment for ADHD
Sarah Medland
Sa2.
Dopamine Transporter in Adults with ADHD: Exploring Epistasis Effects
and Clinical Outcomes in a Follow-up Study
Nina R. Mota, Renata B. Cupertino, Jaqueline B. Schuch, Djenifer Kappel, Diego L.
Rovaris, Bruna Santos, Marcelo Vitor, Veronica Contini, Rafael Karam, Lucas Azeredo,
Eugenio H. Grevet, Claiton H. D. Bau
Sa3.
Pharmacogenetics of Methylphenidate Response and Tolerability
in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder:
Contribution of Dopamine Genes and Prenatal Exposure to Nicotine
Mireia Pagerols, Vanessa Richarte, Cristina Sánchez-Mora, Iris Garcia-Martínez,
Montse Corrales, Margarita Corominas, Bru Cormand, Miguel Casas, Marta Ribasés,
Josep Antoni Ramos-Quiroga
Sa4.
Polymorphisms in the CHRNA5-CHRNA3-CHRNB4 Gene Cluster and their
Interaction with Smoking Behavior in Cognitive Function
Jaqueline Bohrer Schuch, Evelise R. Polina, Diego Rovaris, Djenifer B. Kappel, Nina
R. Mota, Katiane L. Silva, Paula O. Guimarães-da-Silva, Rafael G. Karam, Carlos A. I.
Salgado, Luis Rohde, Eugênio H. Grevet, Claiton Bau
Sa5.
Sa6. Psychiatric Gene Discoveries Shape Evidence on ADHD Biology
Anita Thapar, Joanna Martin, Eric Mick, Alejandro Arias Vasquez, Stephen Scherer,
Russell Schachar, Jennifer Crosbie, Nigel Williams, Barbara Franke, Josephine
Elia, Joseph Glessner, Hakon Hakonarson, Michael Owen, Stephen Faraone, Peter
Holmans
AFFECTIVE DISORDERS
Differential Genetic Susceptibility to Depression Across
Sociodemographic Gradients
Mark Adams, Ana Maria Fernandez, Chris S. Haley, Ian J. Deary, David Porteous,
Andrew McIntosh
Sa7.
Page 81
POSTERS
RNA-sequencing Identifies Differentially Expressed Novel Gene Isoforms
in Bipolar Disorder
Nirmala Akula, Jens R, Wendland, Kwang H. Choi, Barbara K. Lipska, Joel E.
Kleinman, Francis J. McMahon
Sa8.
Sa9. Epigenetic Analysis of the Clock Gene ARNTL in Bipolar Disorder
Susanne Bengesser, Eva Reininghaus, Martina Platzer, Frederike Fellendorf, Armin
Birner, Bernhard Tropper, Nina Lackner, Hans-Peter Kapfhammer, Erwin Petek, Urs
Heilbronner, Thomas Schulze, Mario Schnalzenberger, Robert Fuchs, Anke Waha,
Andreas Waha
Sa10. Increased Sortilin in Depression
Henriette Buttenschon, Ditte Demontis, Mathias Kaas, Betina Elfving, Linda Kaerlev,
Claus Petersen, Anders Børglum, Ole Mors, Simon Glerup
Sa11. Genetic Risk for Major Depressive Disorder as a Predictor of Nausea and
Vomiting During Pregnancy
Lucia Colodro Conde, Baptiste Couvy-Duchesne, Penelope Lind, Jodie Painter, Margie
Wright, Grant Montgomery, Dale Nyholt, Sarah E. Medland
Sa12. CRHR1 and AVPR1B SNP Effects on Major Depressive Disorder:
Influences of Sex and Clinical Heterogeneity
Bruna da Silva, Diego Rovaris, Jaqueline Bohrer Schuch, Angelita P. Aroche, Nina R.
Mota, Renata B. Cupertino, Guilherme P. Bertuzzi, Rafael G. Karam, Eduardo S. Vitola,
Luis Rohde, Luciana Tovo Rodrigues, Eugênio H. Grevet, Claiton Bau
Sa13. Effect of 5-HT Genes on Suicide Attempt: Comparative Analysis in
Schizophrenia and Major Depression
Vincenzo De Luca, Ali bani Fatemi, Alex Perreira Silva, James L. Kennedy, Benoit
Mulsant, Charles F. Reynolds, Eric Lencze
Sa14. A Bidirectional Relationship Between Depression and the Autoimmune
Disorders - New Perspectives from the National Child Development Study
Jack Euesden, Andrea Danese, Cathryn Lewis, Barbara Maughan
Sa15. Secondary Depression in Severe Anxiety Disorders: A Population-based
Study in Denmark
Sandra Meier, Liselotte Petersen, Manuel Mattheisen, Ole Mors, Preben Bo
Mortensen, Thomas Munk
Sa16. Impact of a Single Nucleotide Polymorphism in SIGMAR1 on Major
Depression, Bipolar Disorder and Treatment Response
Laura Mandelli, Changsu Han, Soo-Jung Lee, Ashwin A. Patkar, Prakash S. Massand,
Alessandro Serretti, Chi-Un Pae
Page 82
POSTERS
Sa17. Exome Sequencing in Bipolar Disorder with Comorbid Panic: Gene Set
and Pathway Based-analyses Suggest a Role for Glutamate and Calcium
Signaling
Haroon Sheikh, Mehdi Pirooznia, Jennifer Parla, Melissa Kramer, Fernando Goes,
Dubravka Jancic, Rachel Karchin, Virginia Willour, William McCombie, Peter Zandi,
James Potash
Sa18. Hair Cortisol in Schizophrenia, Bipolar Disorder and Healthy Controls:
Evidence for the Contribution of Bipolar Disorder Genes
Fabian Streit, Amra Memic, Lejla Hasandedić, Liz Rietschel, Josef Frank, Maren Lang,
Stephanie Witt, Andreas J. Forstner, Franziska Degenhardt, Markus Nöthen, Clemens
Kirschbaum, Jana Strohmaier, Ljiljana Oruc, Marcella Rietschel
Sa19. Prioritizing Candidate Genes Based on Biological Pathway and ProteinProtein Interaction Analyses in Obsessive Compulsive Disorder
Carolina Cappi, Eric Halpern, Euripedes Miguel, Thomas Fernandez
ANXIETY DISORDER
Sa20. Combining Genetic and Gene Expression Methods to Identify Biological
Predictors of Response to Cognitive Behavioural Therapy for Anxiety
Disorders
Jonathan Coleman, Kathryn Lester, Robert Keers, Susanna Roberts, Sang hyuck Lee,
Simone de Jong, Tobias Teismann, Andre Wannemüller, Silvia Schneider, Hans-Peter
Jöhren, Jürgen Margraf, Gerome Breen, Thalia Eley
Sa21. Effect of Traumatic Stress on Dopamine-related Gene Expression: A
Preliminary Study
David Freedman, Maria Densmore, Zsofia Nemoda, Ruth Lanius
Sa22. Association Between Genes on Chromosome 19p32.2 and Panic Disorder
Noomi Gregersen, Henriette N. Buttenschøn, Anne Hedemand, Marit N. Nielsen, Hans
A. Dahl, Ann S. Kristensen, Oddbjørg Johansen, David P.D. Woldbye, Angelika Erhardt,
Torben A. Kruse, August G. Wang, Anders D. Børglum, Ole Mors
Sa23. Polymorphisms within the Neuronal Cadherin (CDH2) Gene are
Associated with Obsessive-Compulsive Disorder (OCD) in a South African
Cohort
Nathaniel McGregor, Christine Lochner, Dan Stein, Sian Hemmings
AUTISM
Sa24. The Association Between Genetic Variants and Intelligence Quotient
among Individuals with Autism Spectrum Disorders
Benjamin Ackerman, Yin Yao
Page 83
POSTERS
Sa25. Whole Genome Sequencing Identifies Complex and Balanced De Novo
Structural Variation in Autism
William Brandler, Danny Antaki, Madusudan Gujral, Jonathan Sebat
Sa26. Modeling Autism Using CRISPR/Cas9 and Human Induced Pluripotent
Stem Cells
Eric Deneault, Kirill Zaslavsky, Tadeo Thompson, James Ellis, Stephen Scherer
Sa27. The Number of Genomic Copies at the 16p11.2 Locus Modulates
Language, Verbal Memory and Inhibition
Loyse Hippolyte, Anne, M. Maillard, Borja Rodriguez-Herreros, Aurélie Pain, Sandra
Martin-Brevet, Philippe Conus, Aurélien Macé, Katrin Mannik, Laurent Mottron,
16p11.2 European Consortium, Franck Ramus, Jacques, S. Beckmann, Bogdan
Draganski, Alexandre Reymond, Sébastien Jacquemont
Sa28. Mutation Screening of the PCDH15 Gene in Patients Suffering from
Autism Spectrum Disorders and Schizophrenia
Kanako Ishizuka, Chenyao Wang, Hiroki Kimura, Jingrui Xing, Itaru Kushima, Yuko
Arioka, Akira Yoshimi, Yukako Nakamura, Tomoko Oya-Ito, Yuto Takasaki, Yota Uno,
Takashi Okada, Daisuke Mori, Branko Aleksic, Norio Ozaki
BIOSTATISTICS / BIOINFORMATICS
Sa29. An Integrative Disease-relevant Multi-omics Analysis to Predict Risk for
Stress-related Psychiatric Disorders
Janine Arloth, Nikola Müller, Elisabeth Binder
Sa30. iPsychCNV: A Robust Method for Copy Number Variation Detection on
Dried Blood Spots
Marcelo Bertalan, Shantel Weinsheimer, Thomas Sparsø, Wiktor Mazin, Thomas Werge
Sa31. Prioritization of Risk and Non-risk Variants for Alzheimer’s Disease from
Genome Wide Association Studies – Find My Seq
Kartikay Chadha, Sarah Gagliano, Jon Piptione, David Rotenberg, Jo Knight
Sa32. Transcriptomic Analysis in Early Psychosis: Methodological
Considerations and New Findings
Boris Chaumette, Oussama Kebir, Marie-Odile Krebs
Sa33. coR-Ge: Investigation of Stratified False Discovery Rate Control in
Environments of Complex Correlation
Christopher Cole, Jo Knight
Sa34. Cross-trait Polygenic Risk Score Scan Reveals Shared Genetic Aetiology
Across an Array of Phenotypes
Paul O’Reilly, Adam Socrates, Jack Euesden, Marjo-Riitta Jarvelin
Page 84
POSTERS
Sa35. A New Method for Detecting Associations with Rare Copy-number
Variants
Jin Szatkiewicz, Jung-Ying Tzeng, Patrik Magnusson, Patrick Sullivan, Swedish
Schizophrenia Consortium
DEMENTIA
Sa36. Influence of Genes Involved in Neurotransmission and Neurodevelopment
–Related Pathways on the Risk of Alzheimer Disease
Concetta Crisafulli, Stefano Porcelli, Marco Calabrò, Antonios Politis, Ioannes Liappas,
Diego Albani, Anna Rita Atti, Raffaele Salfi, Rosalba Martines, Gianluigi Forloni, George
N. Papadimitriou, Diana De Ronchi, Alessandro Serretti
Sa37. Associations Between Potentially Modifiable Risk Factors and Alzheimer
Disease: A Mendelian Randomization Study
Søren D. Østergaard, Shubhabrata Mukherjee, Stephen J. Sharp, Petroula Proitsi,
Felix Day, Kevin L. Boehme, Stefan Walter, John S. Kauwe, Laura E. Gibbons, Eric B.
Larson, John F. Powell, Claudia Langenberg, Paul K. Crane, Nicholas J. Wareham,
Robert A. Scott
ENDOPHENOTYPES
Sa38. Age of Onset and Functional Genomics in Anorexia Nervosa
Andrew Bergen, Ruth Krasnow, Harold Javitz, Laura Thornton, Kelly Klump, Walter
Kaye, Price Foundation
Sa39. Investigating the Association of Schizophrenia GWAS Risk Variants
with Cognitive and Brain Structural Deficits in the Genus Consortium
Schizophrenia Sample Collection
Gabriëlla Blokland, Tracey Petryshen, GENUS Consortium
Sa40. Reduce the Search Space using Rare Genetic Conditions - Williams
Syndrome as an Example
Chun Chieh Fan, Andrew Schork
Sa41. Genome-wide Significant Association of the TUBB4A Gene and Social
Dysfunction in the Generation Scotland: Scottish Family Health Study
Viktoria-Eleni Gountouna, Joeri Meijsen, Alexandros Rammos, Lara Andrea Neira
Gonzalez, Mairead Bermingham, Archie Campbell, David Porteous, Kristin Nicodemus
Sa42. Shared Genetic Aetiology Between Cognitive Functions and Mental and
Physical Health in UK Biobank (N = 112,151)
Saskia Hagenaars, Sarah Harris, Gail Davies, Riccardo Marioni, David Liewald,
METASTROKE Consortium, International Consortium for Blood Pressure, CHARGE
Consortium, SpiroMeta Consortium, Breda Cullen, Jill Pell, Andrew McIntosh, Daniel
Smith, Catharine Gale, Ian Deary
Page 85
POSTERS
EPIGENETICS
Sa43. Methylation Analysis of HTR2A Gene in Different Tissues to Assess
Suicide Risk in Schizophrenia and Bipolar Disorder
Ali Bani-Fatemi, Nuwan Hettige, Vincenzo de Luca
Sa44. DNA Methylation Patterns of Several Behaviour-related Gene Promoters:
A Comparative Analysis between Domestic Dog Breeds and the Grey
Wolf
Zsofia Banlaki, Giulia Cimarelli, Zsofia Viranyi, Eniko Kubinyi, Maria Sasvari-Szekely,
Zsolt Ronai
Sa45. Epigenetic Studies in Cocaine and Crack Dependents: Investigation of
Global DNA Methylation
Caroline Camilo, Mariana Maschietto, Henrique C. Vieira, André B. Negrão, Marcelo
Ribeiro, Ronaldo Laranjeira, Helena Brentani, Homero Vallada
Sa46. The DNA Methylome and the HPA Axis Response in Chronic Fatigue
Syndrome
Wilfred de Vega, Santiago Herrera, Paul Manser, Mark Reimers, Suzanne Vernon,
Patrick McGowan
Sa47. Allele-specific DNA Methylation in the Brain: Relevance to Psychiatric
GWAS
Sarah Gagliano, Carolyn Ptak, Denise Mak, Mehrdad Shamsi, Oh Gabriel, Paul
Boutros, Jo Knight, Art Petronis
Sa48. An Epigenome-wide Association Study of Clozapine Use in Treatmentresistant Schizophrenia
Eilis Hannon, Emma Dempster, Joe Burrage, Charles Curtis, Amy Gillespie, David
Dempster, Cerisse Gunasinghe, Leonard Schalkwyk, Fiona Gaughran, Robin Murray,
Marta Di Forti, the CRESTAR Consortium, David Collier, Gerome Breen, Jonathan Mill
Sa49. Hypermethylation of SLC6A4 Promoter in Bipolar Disorder and
Schizophrenia Suppresses its Expression
Tempei Ikegame, Miki Bundo, Tatsuro Asai, Hiroko Sugawara, Kenji Kondo, Masashi
Ikeda, Harumi Saida, Akane Yoshikawa, Fumichika Nishimura, Yoshiya Kawamura,
Chihiro Kakiuchi, Tsukasa Sasaki, Jun Ishigooka, Nakao Iwata, Tadafumi Kato, Kiyoto
Kasai, Kazuya Iwamoto
MISCELLANEOUS OTHER PSYCHIATRIC DISORDERS
Sa50. Loneliness vs. the Big Five: High Phenotypic Correlation Between
Loneliness and Neuroticism is Largely due to Shared Genetic Influences
Abdel Abdellaoui, Karin J.H. Verweij, Michel Nivard, Hill Fung Ip, Jouke-Jan Hottenga,
Gonneke Willemsen, Eco J. de Geus, John T. Cacioppo, Dorret I. Boomsma
Page 86
= ECIP Travel Award
POSTERS
Sa51. Movement Disorders and Other Motor Abnormalities in Adults with
22q11.2 Deletion Syndrome
Erik Boot, Anne Bassett
Sa52. Rare Variant Association Study of Obsessive-Compulsive Disorder by
Whole-exome Sequencing and Unified Mixed-effect Model Analysis
Laura Domenech, Raquel Rabionet, Georgia Escaramís, Eva Real, Daniel Trujillano,
Mattia Bosio, Stephan Ossowski, Angel Carracedo, Pino Alonso, Xavier Estivill
Sa53. Open Board
NEUROIMAGING
Sa54. Orexin System Polygenic Risk Scores Predict Amygdala Reactivity and
Habituation, which Mediate Associations with Anxiety Symptoms
David Baranger, Aline Desmarais, Caitlin Carey, Emily Drabant Conley, Ahmad Hariri,
Ryan Bogdan
Sa55. Association of Anxiety-depression Score with Right Lingual Surface Area:
True Association or False Positive?
Baptiste Couvy-Duchesne, Lachlan Strike, Paul Thompson, Katie McMahon, Greig de
Zubicaray, Nick Martin, Iam Hickie, Margie Wright
Sa56. The Relationship Between Polygenic Risk Score for Bipolar Disorder and
Brain Function During a Facial Affect Labelling Paradigm
Danai Dima, DGerome Breen, Sophia Frangou
OTHER
Sa57. Exploring Physician Perceptions of Psychiatric Genetic Counseling and
Conceptual Barriers to Referrals
Emma Leach, Emily Morris, Hannah White, Angela Inglis, Jehannine Austin
Sa58. NRGR: NIMH Repository and Genomics Resource: New Collections,
Services, and Access Tools to Search Data and Biosamples
Linda Brzustowicz, Veronica Vieland, Jose Luis Ambite, Thomas Lehner, Jay Tischfield
Sa59. Genomewide Association Study of Posttraumatic Stress Disorder in Two
Cohorts of United States Army Soldiers
Chia-Yen Chen, Murray Stein, Robert Ursano, Tianxi Cai, Lisa Colpe, Joel Gelernter,
Steven Heeringa, Sonia Jain, Colter Mitchell, Matthew Nock, Stephan Ripke, Benjamin
Neale, Michael Schoenbaum, Michael Thomas, Ronald Kessler, Jordan Smoller
Sa60. Autosomal Dominant Kidd-null Blood Group Associated with Depression
Roser Corominas, Débora Pérez-García, Miguel Ángel Rodríguez-Granado, Antonio
Balas, Eulalia Rovira, Victoria Campuzano, Diane Krause, Félix García-Sánchez, Luis
A. Pérez-Jurado
Page 87
POSTERS
Sa61. Thinking and Doing: The Effects of Dopamine and Oxytocin Genes and
Executive Function on Mothering Behaviours
Katherine T. Cost, Eva Unternaehrer, André Plamondon, Meir Steiner, Michael Meaney,
James L. Kennedy, Alison S. Fleming
Sa62. The Dowregulation Expression of Proline Oxidase Gene Imbalance
Glutamate in Brains of the Subjects with Obsessive Compulsive Disorder
– A Post Mortem Study
Kátia Cristina de Oliveira, Bianca Cristina Garcia Lisboa, Luzia Lima Carreira, Gisele
Rodrigues Gouveia, Ariane Cristine Moretto, Ricardo de Caires Neves, Carlos Augusto
Pasqualucci, Lea Tenenholz Grinberg, Wilson Jacob-Filho, Beny Lafer, Euripedes
Constantino Miguel, Roseli Gedanke Shavitt, Marcelo Queiroz Hoexter, Carlos Alberto
de Bragrança Pereira, Helena Brentani
Sa63. Impact of Fine-grained Population Structure in a European Sample on
Spurious Associations in GWAS
Tobias Egli, Virginie Freytag, Christian Vogler, Angela Heck, Dominique J.F. de
Quervain, Andreas Papassotiropoulos, Annette Milnik
Sa64. Clinical Characterization of Neurexin1 Deletions and their Role in
Neurodevelopmental Disorders
Jacqueline Fitzgerald, Jeremy Hall, Marianne Van Den Bree, Linh Duong, Thomas
Werge, Richard Delorme, Anne-Claude Tabet, Hilde Peeters, Nele Cosemans, Ilse
Noens, Ramon Novell, Susanna Esteba, Sanbing Shen, Louise Gallagher
Sa65. DRD4, APOE and DNAmt Polymorphisms in Indigenous Population of
Mexico
Blanca Zoila González Sobrino, Carlos Cruz Fuentes, Ana Julia Aguirre Samudio,
Magdalena Briones
Sa66. A Bivariate Genome-wide Association Study (GWAS) of Depressive
Symptoms and Fasting Glucose/Insulin
Kadri Haljas, Jari Lahti, Azmeraw T. Amare, Behrooz Z. Alizadeh, Harold Snieder,
Johan Eriksson, Katri Räikkönen
OTHER CHILDHOOD PSYCHIATRIC DISORDERS
Sa67. Corticotropin-releasing Hormone Related Genes and Aggressive
Behaviour: Association in a Pediatric Sample
Lyubov Bryushkova, Clement Zai, Sheng Chen, James L. Kennedy, Joe Beitchman
Sa68. Identification of Genetic Interactions Involved in Dyslexia Pathogenesis
Nazanin Karbalai, Darina Czamara, Kristina Moll, Franck Ramus, Rainer Malik, Thomas
S. Scerri, Johannes Schumacher, Andrew P. Morris, Thomas Bourgeron, Anthony P.
Monaco, Silvia Paracchini, Simon E. Fisher, Markus Nöthen, Gerd Schulte-Körne,
Bertram Müller-Myhsok
Page 88
POSTERS
Sa69. A Convergence of Transcriptional and Genetic Evidence Implicates
Neuronal Cell Adhesion Proteins in Developmental Language Impairment
Jacob Michaelson, Bruce Tomblin, Ethan Bahl
PHARMACOGENETICS
Sa70. Combinatorial Pharmacogenomics to Optimize Depression Therapy:
Evidence from Clinical and Economic Studies
C. Anthony Altar
Sa71. Systems Genetics Analysis of Antidepressant Treatment
Majbritt Busk Madsen, Lisette Kogelman, Haja Kadarmideen, Henrik Berg Rasmussen
Sa72. Genome-wide Significant DRD2 Schizophrenia Risk Variant Association
with Clozapine Treatment Outcome
Eric Huang, Malgorzata Maciukiewicz, Clement C. Zai, Arun K. Tiwari, Jiang Li,
Steven G. Potkin, Jeffrey A. Lieberman, Herbert Y. Meltzer, Daniel J. Müeller, James L.
Kennedy
Sa73. Pharmacogenomic Study of Interferon-induced Depressive State
Kohei Kawase, Masashi Ikeda, Kenji Kondo, Takeo Saito, Ayu Shimasaki, Nakao Iwata
Sa74. The CREB-regulated Transcription Coactivator 1 (CRTC1) Gene and
Maxine Kish, Inga Muser, Arun Tiwari, Victoria Marshe, Sivasangary Ganeshan, Natalie
Freeman, Jeffrey Lieberman, Herbert Meltzer, James L. Kennedy, Daniel Müeller
Sat75. The ITIH3 rs2535629 Variant and Its Role in Antipsychotic
Eva Brandli, Tristram Lett, Nabilah Chowdhury, Arun Tiwari, Herbert Meltzer, Steven
Potkin, Jeffrey Lieberman, James L. Kennedy, Daniel Müeller
Sa76. The Role of SKA2 Genetic Variants in Response to Citalopram
Amanda Lisoway, Clement Zai, Arun K. Tiwari, Zachary Kaminsky, James L. Kennedy
Sa77. Investigating Associations Between IL-1beta, IL-2, IL-6, TSPO and BDNF
Variants and Response to Duloxetine or Placebo Treatment in Patients
with Major Depression
Victoria Marshe, Malgorzata Maciukiewicz, Arun K. Tiwari, Natalie Freeman, James L.
Kennedy, Susan Rotzinger, Sidney Kennedy, Daniel Müeller
Sa78. A Pharmacogenetic Association Study of the CYP2D6*17 Polymorphism
and Tardive Dyskinesia in Black Psychotic Patients on Typical
Antipsychotics
Josiah Masuka, Star Khoza, Dixon Chibanda, Walter Mangezi, Charles Nhachi
Page 89
POSTERS
Sa79. Association of Lithium Response to Telomere Length in Bipolar Disorder
in a Brazilian Cohort
Leandro Michelon, Daniela Martinez, Thais Chile, Gisele Gouveia, Caroline Camilo,
Martin Schalling, Homero Vallada
Sa80. Duration of Therapy and Years of Illness Before Lithium Treatment have
Opposite Effects on Leukocyte Telomere Length in Bipolar Disorder
Patients
Claudia Pisanu, Gioia Baggiani, Donatella Congiu, Carla Melis, Paola Niola, Paola
Caria, Giovanni Severino, Roberta Vanni, Alberto Bocchetta, Maria Del Zompo,
Caterina Chillotti, Alessio Squassina
SCHIZOPHRENIA
Sa81. Polygenic Risk Score for Schizophrenia is Associated with Treatment
Resistant Schizophrenia during the First Five Years after First Contact
with Mental Health Services
Olesya Ajnakina, John Lally, Marta Di Forti, Javier Lopez-Morinigo, Anthony S.
David, Paola Dazzan, Carmine Pariante, Valeria Mondelli, Fiona Gaughran, Jonathan
Coleman, Robin Murray, Gerome Breen, Evangelos Vassos
Sa82. Investigation of Rare Genetic Variation in Schizophrenia and Bipolar
Disorder
Mariam Aleissa, Nicholas Bass, Andrew McQuillin, David Curtis, Sally Sharp, Niamh
O’Brien, Alessia Fiorentino
Sa83. Identifying Rare Variation in Cases of Schizophrenia in the Isolated
Population of the Faroe Islands using Whole-genome Sequencing
Thomas Als, Francesco Lescai, Hans A. Dahl, Ditte Demontis, August Gabriel Wang,
Gudrid Andorsdottir Ellefsen, Oddbjørg Johansen, Marjun Biskopstø, Jakob Grove,
Mette Nyegaard, Lars Bolund, Ole Mors, Jun Wang, Anders Børglum
Sa84. Genomic Profiling Reveals CNV-EQTIS in and Around the Imprinted
Region of 15q11.2 may Confer Higher Risk in Developing Schizophrenia
Joshua Atkins, Ian Gould, Chantel Fitzsimmons, Melissa Green, Paul Tooney, Rodney
Scott, Vaughan Carr, Murray Cairns
Sa85. Open Board
Sa86. Risk Alleles for C-Reactive Protein Appear to be Protective for
Schizophrenia
Anson Wong, Buhm Han, Soumya Raychaudhun, Joanne Knight, Jennie Pouget
Page 90
POSTERS
Sa87. Whole Genome Sequencing of Multiply-affected Schizophrenia and
Bipolar Disorder Families from the Azores and Madeira
T. Bernard Bigdeli, Benke Kelly, Brion Maher, James Knowles, Helena Medeiros, Janet
Sobell, Elizabeth Bevilacqua, Jennifer Moran, J. Nemesh, Giulio Genovese, Robert
Handsaker, Colm O’Dushlaine, Michele Pato, Steven McCarroll, Carlos Pato, Ayman
Fanous
Sa88. Shared Genetic Risk Factors between Schizophrenia and Sleep Quality in
a Population-based Cohort of Australian Twins
Enda Byrne, Nick Martin
Sa89. Assessing the Threshold Model for Schizophrenia Using In-depth
Genome Sequence and Methylation Differences in Monozygotic Twins
Discordant for the Disease
Christina Castellani, Melkaye Melka, Jane Gui, Benjamin Laufer, Eric Diehl, Richard
O’Reilly, Shiva Singh
Sa90. Preliminary Study for Association of Genome-wide Significant Glutamate
Receptor, Iontropic, N-methyl D-asparate 2A Schizophrenia Risk Variant
with Clozapine Response
Cheng Chen, Clement Zai, Sajid Shaikh, Jeffrey Lieberman, Steven Potkin, Daniel
Müeller, James L. Kennedy
Sa91. Impaired Presynaptic Transmission Following Over-expression of MIR-137
James Crowley, Enqi He, Sara Grasman, Rien Dekker, August Smit, Kensuke
Sakamoto, Patrick Sullivan, Matthijs Verhage
Sa92. Application of a Weighted Burden Test to Whole Exome Sequence Data
for Obesity and Schizophrenia
David Curtis
Sa93. Gene-set Analysis Based on the Pharmacological Profiles of Drugs to
Identify Repurposing Opportunities in Schizophrenia
Simone de Jong, Lewis Vidler, Younes Mokrab, David Collier, Gerome Breen
Sa94. DNA Sequencing in Multiplex Families with Schizophrenia and Affective
Disorder
Lynn DeLisi, Oliver Homann, Kira Misura, Paul Nelson, Monica Landi, Stefan
McDonough
Sa95. Gene Pathway-based Genetic Subtyping of Schizophrenia: Novel
Statistical Methods and Application
Anna Docherty, Silviu Bacanu, Alexis Edwards, Ayman Fanous
= ECIP Travel Award
Page 91
POSTERS
Sa96. Extended Psychosis Phenotype and Gene Environment Interactions: A
Follow-up Study on a Large Community Based Population
Hayriye Elbi, Umut Kirli, Tolga Binbay, Koksal Alptekin, Bulent Kayahan, Nesli Zagli,
Kubra Yildirim, Ferda Ozkinay, Huseyin Onay, Duygu Keskin, Jim Van Os
Sa97. Investigating Causality in Associations Between Smoking and
Schizophrenia
Suzi Gage, Hannah Jones, Amy Taylor, Stanley Zammit, Marcus Munafo
Sa98. Implications of DGCR8 Overexpression on Neuronal Microrna Expression
and Neuronal Function
Michael Geaghan, Murray Cairns, Adam Carroll
Sa99. Convergence Between Antipsychotic-induced Transcriptomic Changes
and Schizophrenia Risk Genes
Yunjung Kim, Paola Giusti-Rodriguez, James Crowley, Randal Nonneman, Allison
Ryan, Corey Quackenbush, Maria D. Iglesias de Ussel, Phil Lee, Wei Sun, Fernando
Pardo-Manuel de Villena, Patrick Sullivan
Sa100. The Relationship Between CNS Cell-type Specific Gene Expression and
Schizophrenia
Jun Han, Valentina Escott-Price, Michael O’Donovan, Michael Owen, Andrew
Pocklington
Sa101. Effects of Copy Number Variants in Schizophrenia on Longitudinal
Psychosocial Functioning
Katrin Gade, Urs Heilbronner, Franziska Degenhardt, Jana Strohmaier, Maren Lang,
Josef Frank, Jens Treutlein, Anna Rohrbacher, Andrea Hofmann, Stephanie Witt, Sven
Cichon, Markus Nöthen, Marcella Rietschel, Thomas Schulze
Sa102. Migration and Ethnicity as Predictors for Suicide Risk in Schizophrenia
Using Ancestry-informative Markers
Nuwan Hettige, Vincenzo de Luca
Sa103. Association and Predictive Value of Genetic Risk Score for Schizophrenia
and Cognitive Profiles in Unaffected Siblings: The Group Study
Md. Atiqul Islam, Piotr J. Quee, Edwin R. van den Heuvel, Behrooz Z. Alizadeh,
GROUP Investigators
Sa104. Identification of a Susceptibility Locus in a Consanguineous Family with
Multiple Schizophrenia-affected Members
Jose Ivorra, Tariq Mahmood, Manir Ali, Eleftheria Pervolaraki, Shabana Khan, Clare
Logan, Alastair G. Cardno, Colin Johnson, Iain D. Wilkinson, Peter Woodruff, Steven J.
Clapcote, Chris F. Inglehearn
= ECIP Travel Award
Page 92
POSTERS
Sa105. Identification of Genetic Variants Associated with Resilience to
Psychiatric Disorders among Individuals at High Genetic Risk
Daniel Tylee, Jonathan Hess, Stephen Glatt, Stephen Faraone
Sa106. Behavioural and Transcriptomic Correlates with Clozapine Response in
Zebrafish
Joana Viana, Nick Wildman, Gregory Paull, Eduarda Santos, Jonathan Mill
SUBSTANCE ABUSE
Sa107. Khat Addiction and Psychotic Symptoms: A Feasibility Study on Largescale Genetic Approaches in Southwestern Ethiopia
Kristina Adorjan, Fasil Tessema, Zeleke Mekonnen, Markos Tesfaye, Sergi Papiol, Ezra
Susser, Thomas Schulze
Sa108. Identifying Novel Transcriptome Level Changes Related to Chronic
Alcohol Abuse
Dhivya Arasappan, Sean Farris, R. Dayne Mayfield
Sa109. Racial Differences in Genetic and Environmental Influences on
Adolescent and Young Adult Cigarette Use
Cristina Bares, Kenneth Kendler, Hermine Maes
Sa110. Associations Between Polygenic Risk for Psychiatric Disorders and
Substance Dependence
Caitlin Carey, Arpana Agrawal, Sarah Hartz, Laura Bierut, Ryan Bogdan
Sa111. Exploring SNPs in miRNA Binding Sites of Genes Expressed in Brain as
Risk Factors for Substance Dependence
Noèlia Fernàndez-Castillo, Judit Cabana-Domínguez, Carlos Roncero, Carmen Barral,
Jesús Pérez-Pazos, Alfonso Abad, Joan Alvarós, Miguel Ángel Cantillo, Eduardo
Castrillo, Laia Rodriguez-Cintas, Gemma Prat, Miguel Casas, Cristina Sanchez Mora,
Marta Ribasés, Bru Cormand
Sa112. Identification of Common and Rare Risk Variants in the Alcohol
Dependence Candidate Gene GATA4
Franziska Degenhardt, Laurenz Krämer, Josef Frank, Andrea Hofmann, Jens Treutlein,
Stephanie Witt, Maren Lang, Fabian Streit, Jana Strohmaier, Karl F. Mann, Sabine
Hoffmann, Falk Kiefer, Rainer Spanagel, Marcella Rietschel, Markus Nöthen
Sa113. Expanding the Phenotypic Boundaries of Alcohol and Nicotine
Consumption: A Search for Rare Genetic Variants in a General Population
Sample of 16,000 Subjects
Eske Derks, Andries Marees, Kim Cerrone, Anke Hammerschlag, Wim van den Brink,
Danielle Posthuma, BBMRI-substance Consortium
Page 93
POSTERS
Sa114. HIV-related Neurocognitive Impairment is Related to Polymorphisms in
CCR2 and CD163 in Substance and Non-substance Using Groups
Michelle Jacobs, Desiree Byrd, German Nudelman, Susan Morgello
Sa115. DNA Methylation of the Dopamine Transporter Gene and Epigenetic
Defects in Alcohol Dependence
Andrzej Jasiewicz, Anna Grzywacz, Błażej Rubiś, Iwona Małecka, Aleksandra
Suchanecka, Marcin Jabłoński, Jerzy Samochowiec
Sa116. Searching for New Genetic Risk Factors Affecting miRNA-mediated
Regulation on Persistent ADHD: Evidence for the Involvement of the miR34c Cluster
Iris Farcia, Cristina Sanchez Mora, Mireia Pagerols, Vanessa Richarte, Montse
Corrales, Begona Olivares, Bru Cormand, Jose Antonio Ramos-Quiroga, Miguel
Casas, Marta Ribasés
Page 94
POSTERS
ADHD
An Integrative Approach to Investigate the Respective Roles of Singlenucleotide Variants and Copy-number Variants in Attention-Deficit/
Ana Cecilia Feio dos Santos, Leandro de Araújo Lima, Sintia Iole Belangero, Ary
Gadelha, Rodrigo Affonseca Bressan, Ana Tahira, Viviane Neri de Souza Reis, Xiao
Chang, Renata Pellegrino, Lifeng Tian, Joseph T. Glessner, Luis Augusto Rohde,
Patrick M.A. Sleiman, Hakon Hakonarson, Helena Brentani
Su1.
Genetic Overlap Between Intellectual Disability and Attention-Deficit/
Marieke Klein, Anne van Rens, Elena Shumskaya, Martine Hoogman, Psychiatric
Genomics Consortium ADHD Working Group, Han Brunner, Alejandro Arias-Vasquez,
Barbara Franke
Su2.
Polygenic Risk Scores for Clinical ADHD are Associated with Impaired
Educational Achievement and Lower IQ in Children and Adults from the
General Population
Evie Stergiakouli, Joanna Martin, Marian Hamshere, Jon Heron, Beate St Pourcain,
Nicholas Timpson, Anita Thapar, George Davey Smith
Su3.
Polygenic Risk Score and Family History Independently Predict Conduct
Disorder in ADHD
Anita Thapar, Sharifah Shameem Agha, Joanna Martin, Michael O’Donovan, Stanley
Zammit, Kate Langley
Su4.
Methylomic Analysis of Salivary DNA in Childhood ADHD Identifies
Altered DNA Methylation in VIPR2
Beth Wilmot, Rebecca Fry, Lisa Smeester, Erica Musser, Jonathan Mill, Joel Nigg
Su5.
Differences in Body Mass Index According to FTO Genotype in Mexican
Patients with Bipolar Disorder
Adriana Díaz-Anzaldúa, Yolanda Ocampo-Mendoza, José Octavio HernándezLagunas, Federico Alejandro Díaz-Madrid, Francisco Romo-Nava, Francisco JuárezGarcía, Hiram Ortega-Ortiz, Alejandro Díaz-Anzaldúa, Doris Gutiérrez-Mora, Claudia
Becerra-Palars, Carlos Berlanga-Cisneros
Su6.
= ECIP Travel Award
Page 95
POSTERS
AFFECTIVE DISORDERS
Investigating Relationships Between Molecular Markers and Clinical
Characteristics of Major Depression among Han Chinese Women
Alexis Edwards, Steven Aggen, Na Cai, T. Bernard Bigdeli, Roseann Peterson, Silviu
Bacanu, Bradley Webb, Anna Docherty, Kenneth Kendler, Jonathan Flint, CONVERGE
Consortium
Su7.
Delineation of the Mutational Spectrum in Two Susceptibility Genes for
Bipolar Disorder, Neurocan (NCAN) and Adenylate Cyclase 2 (ADCY2)
Sascha Fischer, Stefan Herms, Thomas Mühleisen, Jana Strohmaier, Margitta
Borrmann-Hassenbach, Fabian Streit, Andreas Forstner, Anna Maaser, Margot Albus,
Wolfgang Maier, Thomas Schulze, Marcella Rietschel, Markus Nöthen, Sven Cichon,
Per Hoffmann
Su8.
Brain Derived Neurotrophic Factor (BDNF) Gene Val66Met Polymorphism
in Patients with Mood Disorder in Calabar, Nigeria; A Case-control Study
Ibene Ekpor, Mary Koofreh, Owoidoho Udofia
Su9.
Su10. Study of Microrna-related Single-nucleotide Polymorphisms in Major
Depressive Disorder
Elisabetta Maffioletti, Chiara Congiu, Cristian Bonvicini, Carlo Maj, Alessandra Minelli,
Marco Bortolomasi, Giuseppe Maina, Luisella Bocchio-Chiavetto, Masimo Gennarelli
Su11. GAD1 Polymorphisms are Associated with Glutamatergic Activity in the
Anterior Cingulate in Bipolar I Disorder
Márcio Soeiro-de-Souza, Rodrigo Machado-Vieira, Ricardo Moreno, Thais Chile,
Gisele Gouveia, Bruno Pastorello, Cláudia Leite, Anke Henning, Maria Concepcion
Otaduy, Homero Vallada
Su12. Mapping Genes using a Hidden Markov Model for Bipolar Affective
Disorder in Consanguineous Families
Ricardo Harripaul, Mina Ohadi, Narges Moghimi, John Vincent
Su13. GSK3β: A Plausible Mediator of Hippocampal Change Induced by
Erythropoietin Treatment in Depression
Becky Inkster, Andy Simmons, James Cole, Erwin Schoof, Rune Linding, Tom Nichols,
Pierandrea Muglia, Philipp Saemann, Peter McGuffin, Cindy Fu, Gwyneth Zai, Kamilla
Miskowiak, Paul Matthews, Kristin Nicodemus
Su14. LPS Stimulated Whole Blood RNA Sequencing of MDD Subtypes
Rick Jansen, Femke Lamers, Yuri Milaneschi, Jouke-Jan Hottenga, Gonneke
Willemsen, Gerard van Grootheest, Hailiang Mei, BIOS Consortium, Dorret I.
Boomsma, Brenda WJH Penninx
Page 96
= ECIP Travel Award
POSTERS
Su15. Exome Sequencing Identifies De Novo Mutations in Bipolar Disorder
Muneko Kataoka, Nana Matoba, Tomoyo Sawada, An-A Kazuno, Mizuho Ishiwata,
Kumiko Fujii, Koji Matsuo, Jared Roach, Atsushi Takata, Tadafumi Kato
Su16. Somatic Complaints of Depression and Melatonin Receptor MTNR1A
Gene: Results from the CHARGE Consortium
Ayse Demirkan, Jari Lahti, Nese Direk, CHARGE Consortium Depression Working
Group, Joanne Murabito, Henning Tiemeier, Cornelia van Duijn, Katri Räikkönen
Su17. A Genome-wide Quantitative Trait Locus (QTL) Linkage Scan of Neo
Personality Factors in Latino Families Segregating Bipolar Disorder
Byung Dae Lee, Michael Escamilla, Suzanne Gonzalez, Mercedes Ramirez, E., Juan
Zavala, Javier Conteras, Laura Almasy, Henriette Raventós, Humberto Nicolini, Erika
Villa, Marco Rodriquez
Su18. Genome-wide Association Analysis of Depressive Symptomatology in
Two Representative Cohorts in the United States and United Kingdom
Krisztina Mekli, James Nazroo, Jinkook Lee, Carol Prescott, Drystan Phillips, Thalida
Arpawong, Adam Stevens, Neil Pendleton
ANXIETY DISORDERS
Su19. Genome-wide Association Study of Panic Disorder
Andreas J. Forstner, Christiane Wolf, Eduard Maron, Angelika Erhardt, Elias Eriksson,
Iiris Hovatta, Catharina Lavebratt, Christer Allgulander, David P. D. Woldbye, Ole
Mors, Bertram Müller-Myhsok, Elisabeth B. Binder, Christian Rück, Jürgen Deckert,
Johannes Schumacher
Su20. Whole-exome Sequencing Implicates DGKH as a Risk Gene for Panic
Disorder in the Faroese Population
Noomi Gregersen, Francesco Lescai, Thomas Als, Henriette N. Buttenschøn, Anne
Hedemand, Marjun Biskopstø, August G. Wang, Anders D. Børglum, Ole Mors, Ditte
Demontis
Su21. The Identification of Novel Genes in Anxiety Disorders: A Gene X
Environment Correlation and Interaction Study
Nathaniel McGregor, Jacqueline Dimatelis, Sian Hemmings, Craig Kinnear, Dan Stein,
Vivienne Russell, Christine Lochner
Su22. Potential Interaction Effects of FK506 Binding Protein 5 and Childhood
Maltreatment on Anxiety in a Sample of Aggressive Children
Arqam Qayyum, Clement Zai, James L. Kennedy, Joe Beitchman
Page 97
POSTERS
AUTISM
Su23. Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and
Medical Comorbidities
Debra D’Angelo, Sébastien Lebon, Qixuan Chen, Sandra Martin-Brevet, LeeAnne
Snyder, Anne Maillard, Raphael Bernier, ECHO Study, 16p11.2 European Consortium,
Simons VIP Consortium, Marianne Van Den Bree, John Spiro, Alexandre Reymond,
Wendy Chung, Sébastien Jacquemont
Su24. RNA-seq Analysis of Human Neurons Derived from Induced Pluripotent
Stem Cells Containing a Knockout of the Autism and Schizophrenia
Candidate Gene CHD8 (Chromodomain-Helicase-DNA-binding Protein)
Ping Wang, Mingyan Lin, Erika Pedrosa, Anastasia Hrabovsky, Wenjun Guo, Zheng
Zhang, Deyou Zheng, Herb Lachman
Su25. Functional Analysis of the Autism and Intellectual Disability Gene
PTCHD1 Reveals Hedgehog Receptor-like Functions and PDZ-binding
Domain-specific Regulation of CNTNAP1 and NLGN1
Kirti Mittal, Bryan Degagne, Taimoor Sheikh, John Vincent
Su26. Exome and Transcriptome Data Integration in Autism Spectrum Disorder
Trios Revealed PPI Sub-networks Affected with De Novo and Inherited
Rare Variants Grouping Patients by Different Biological Pathways
Viviane Neri de Souza Reis, Ana Tahira, Bianca Lisboa, Ana Cecilia Feio dos Santos,
Joana Portolese, Elaine Zachi, Leandro Lima, Sérgio Simões, Arthur Feltrin, Flavia
Sato, Ana Paula Martins dos Santos, Daniela Bordini, Décio Brunoni, Suely Kazue
Nagahashi Marie, Helena Brentani
Su27. Developmental Changes in Genetic Relationships Between Traits and
Disease: Analyses of Genetic Overlaps Between Social-communication
Difficulties, Autism Spectrum Disorders and Schizophrenia
Beate St Pourcain, Elise Robinson, Brendan Bulik-Sullivan, Verneri Anttila, Julian
Maller, David Skuse, Susan Ring, David Evans, Nicholas Timpson, Angelica Ronald,
Jakob Grove, Anders Borglum, Preben Bo Mortensen, Mark Daly, George Davey Smith
Su28. Transcriptome-wide Mega-analysis of Blood-based Microarray Data
Comparing Individuals with Autism Spectrum Disorder and Typically
Developing Subjects
Daniel Tylee, Jonathan Hess, Rahul Barve, Jeffery Chang, Irva Hertz-Picciotto,
Boryana Stamova, Sekwon Kong, Stephen Glatt
BIOMETRICS / BIOINFORMATICS
Su29. Similarity Network Fusion Uncovers Clinically Relevant Patient Subtypes
within Pediatric Obsessive Compulsive Disorder Patients
Lauren Erdman, Paul Arnold, Gregory Hanna, Anna Goldenberg
Page 98
POSTERS
Su30. A Freesurfer View of the Cortical Transcriptome Generated from the Allen
Human Brain Atlas
Leon French, Tomáš Paus
Su31. Distinguishing Biological from Technological Signals in the Functional
Interpretation of Neuropsychiatric Disease Genes
Sara Ballouz, Jesse Gillis
Su32. Identification of Shared Genes and Molecular Pathways in the
Dorsolateral Prefrontal Cortex of Subjects with Three Major Psychiatric
Disorders
Dong Hoon Oh, Sanghyeon Kim
Su33. Leveraging Pleiotropy to Identify Genetic Variants for Psychiatric
Disorders with Underpowered GWAS
Paul O’Reilly, Samir Di Marchi, Heather Porter
Su34. Speeding up the Analysis of Read-count Data from High-throughput
Sequencing
Weibo Wang, Wei Sun, Wei Wang, Jin Szatkiewicz
DEMENTIA
Su35. Interaction Between Amylin Gene Polymorphism and Brain Beta-amyloid
Burden Predicts Cognitive Performance in Alzheimer’s Disease: A
Genome-wide Interaction Study
Tina Roostaei, Arash Nazeri, Daniel Felsky, Aristotle Voineskos
Su36. Vitamin D Receptor Gene Polymorphisms in Alzheimer’s Disease Patients
of Japan
Takahiro Shinkai
Su37. Possible Evidence of Altered Synaptic Gene Expression in Individuals at
High Genetic Risk of Alzheimer’s Disease
Lindsey Sinclair, Seth Love
ELSI, COUNSELING AND GENETIC TESTING
Su38. “Neurodevelopmental” Copy Number Variants and Clinical Risk:
A Pediatric Record Population Study
Kwangmi Ahn, Steven An, Frank Mentch, Chally Kao, Hakon Hakonarson, Judith
Rapoport
Su39. Exploring the Process of Decision-making about Participation in Genetic
Research on Mental Illness
Heather Andrighetti, Alicia Semaka, Jehannine Austin
= ECIP Travel Award
Page 99
POSTERS
Su40. Design, Implementation and Outcomes of a “Psychiatric Genetics for
Genetic Counsellors (PG4GC)” Workshop in the UK and Creation of the
International Society for Psychiatric Genetic Counselling (ISPGC)
Kevin McGhee, Angela Inglis, Jehannine Austin
ENDOPHENOTYPES
Su41. A Genome-wide Association Study of Emotion Recognition in Faces,
Used as a Predictor of Response to Cognitive Behavioural Therapy
Jonathan Coleman, Kathryn Lester, Marcus Munafo, Gerome Breen, Thalia Eley
Su42. The Role of SCN2A rs10174400 Polymorphism on Cognitive and Brain
Structure in Asian Schizophrenia
Max Lam, Simon Collinson, Jimmy Lee, New Fei Ho, Yik Yeng Teo, Sim Kang
Su43. Wide Association Analyses of Bio-classes of Electroencephalogram
Features for Schizophrenia and Bipolar Disorders
Yen-Feng Lin, Chia-Yen Chen, Bruce M. Cohen, Deborah Levy, Dost Ongur, Mei-Hua
Hall
Su44. High Resolution Linkage and Association Analyses of Cognitive
Deficit and Schizophrenia in the Western Australian Family Study of
Schizophrenia
Nina McCarthy, Phillip Melton, Johanna Badcock, Vera Morgan, Milan Dragovic, Bharti
Morar, Eric Moses, Assen Jablensky
Su45. Genome-wide Association Study Implicates Low-frequency and Common
Variants in Brain Folding
Thomas Müehleisen, Alexander Teumer, Katharina Wittfeld, Christiane Jockwitz,
Sandra van der Auwera, Stefan Herms, Per Hoffmann, Markus Nöthen, Svenja
Caspers, Susanne Moebus, Katrin Hegenscheid, Karl Zilles, Katrin Amunts, Hans
Grabe, Sven Cichon
Su46. Independent and Interactive Effects of CNTNAP2 on Rapid Auditory
Processing in 6-month-old Italian Infants
Valentina Riva, Chiara Cantiani, Caterina Piazza, April Benasich, Massimo Molteni,
Ginette Dionne, Cecilia Marino
Su47. Catechol-O-Methyltransferase Gene (val158met) Polymorphisms and
Anxiety Symptoms in Early Childhood: The Role of Hypothalamuspituitary-adrenal Axis Reactivity and Early Life Stress
Haroon Sheikh, Shiva Singh
Page 100
POSTERS
EPIGENETICS
Su48. Epigenome-wide Association Study (EWAS) in a Panic Disorder Cohort
Stella Iurato, Tania Carrillo-Roa, Marcus Ising, Susanne Lucae, Elisabeth Binder,
Angelika Erhardt
Su49. Methylome Cellular Signatures Induced by Acute Exposure to Twelve
Antipsychotic and Neurotransmitter Drugs
Aaron Jeffries, Eilis Hannon, Emma Dempster, Joe Burrage, David Evans, David
Collier, Jonathan Mill
Su50. Old DNA for New Epigenetics Analysis? Be Aware of the Cell
Heterogeneity in Buccal Swab Samples
Emese Kruk, Erzsebet Zsofia Horvath, Zsofia Nemoda
Su51. Severe Psychosocial Deprivation in Early Childhood is Associated with
Hypermethylation Across a Region of the CYP2E1 Gene
Sarah Marzi, Robert Kumsta, Joana Viana, Michael Rutter, Jonathan Mill, Edmund
Sonuga-Barke
Su52. Methylomic Analysis of Autism Brain: Disease-associated Variation and
Support for a Neurodevelopmental Component to Etiology
Chloe Chung Yi Wong, Neel Parikshak, Helen Spiers, Nicholas J. Bray, Laura Lysenko,
Claire Troakes, Joana Viana, Eilis Hannon, Leo Schalkwyk, Daniel Geschwind,
Jonathan Mill
FUNCTIONAL GENOMICS & MODEL ORGANISMS
Su53. Transcriptomic Consequences of Loss of Function Mutations in TCF4
Matthew Hill, Derek Blake
Su54. Reduced Expression of the Ahi1 Gene is Associated with an Anxiety
Resilient Phenotype: Evidence from a Transgenic Mouse Model
Amit Lotan, Tzuri Lifschytz, Ben Mernick, Gilly Wolf, Pavel Tatarsky, Gadi Goelman,
Bernard Lerer
Su55. Common SNP Heritability of Dorsolateral Prefrontal Cortex RnaseqDerived Gene Expression in Schizophrenia, Bipolar Disorder and Control
Samples in the Commonmind Consortium
Eli Stahl#, Solveig Sieberts#, Menachem Fromer, Panos Roussos, CommonMind
Consortium
Page 101
POSTERS
Su56. The Effect of the Burden of Copy Number Variants on Behavioural
and Psychiatric Symptoms in Adults with Idiopathic Intellectual
Disability: A Methodological Approach Utilizing Brain Expression and
Haploinsufficiency Data
Giovanni Giaroli, Nicholas Bass, Kate Wolfe, Andre Strydom, Andrew McQuillin
Su57. Can Public Consortia Data be used to Predict Anorexia Disorder
Subtypes by Polygenic Scoring?
Rebecca Harrison, Qingqing Xu, Paul O’Reilly, Gerome Breen
Su58. Genome-wide Association Study of Pathological Gambling
Maren Lang, Tagrid Leménager, Dilafruz Juraeva, Mira Fauth-Bühler, Fabian Streit,
Stephanie H. Witt, Franziska Degenhardt, Falk Kiefer, Hans-Jörgen Grabe, Ulrich John,
Markus M. Nöthen, Christian Meyer, Hans-Jürgen Rumpf, Marcella Rietschel, Karl F.
Mann
Su59. Transcriptome Meta-analysis of Rodent Models of Aggression
Yanli Zhang-James, Jonathan Hess, Karim Malki, Stephen Glatt, Stephen Faraone
NEUROIMAGING
Su60. The Working Memory Brain Network is Affected by the Polygenic Risk
Score for Bipolar Disorder
Danai Dima, Gerome Breen, Sophia Frangou
Su61. Differential Effects of Disease Associated ST8SIA2 Haplotype on Cortical
White Matter in Schizophrenia
Janice Fullerton, Paul Klauser, Rhoshel Lenroot, Alexander Shaw, Anna Heath, Murray
Cairns, Rodney Scott, Peter Schofield, Cynthia Shannon Weickert, Christos Pantellis,
Alex Fornito, Tom Whitford, Andrew Zalesky
Su62. Association of SNP rs10026792 in ADD1 with Brain Activation Differences
During the Encoding of Emotional Stimulus Material
Leo Gschwind, Christian Vogler, Matthias Fastenrath, David Coynel, Annette Milnik,
Dominique J.F. de Quervain, Andreas Papassotiropoulos
OTHER
Su63. First GWAS Meta-analysis on Nausea and Vomiting During Pregnancy
Lucia Colodro Conde, Lavinia Paternoster, Penelope Lind, Jodie Painter, Margie
Wright, Grant Montgomery, Dale Nyholt, Sarah E. Medland
Page 102
POSTERS
Su64. SNP-based Heritability Estimates of Personality Dimensions: Findings
from CONVERGE
Anna Docherty, Roseann Peterson, T. Bernard Bigdeli, Alexis Edwards, Kenneth
Kendler, Jonathan Flint
Su65. Elucidating the Shared Genetic Architecture of Eight Psychiatric
Disorders
Phil Lee, Cross Disorder Group of the Psychiatric Genomics Consortium
Su66. Transcriptome Study in Striatum of Obsessive Compulsive Disorders
(Postmortem Study)
Bianca Lisboa, Kátia de Oliveira, Luzia Carreira Lima, Renato Puga, Gustavo Ribeiro,
Ana Tahira, José Marcelo Farfel, Renata Eloah de Lucena Ferretti-Rebustini, Wilson
Jacob-Filho, Euripedes Constantino Miguel, David Pauls, Roseli Shavitt, Marcelo
Hoexter, Carlos Alberto de Bragança Pereira, Helena Brentani
Su67. Applying Schizophrenia Based Polygenic Risk Scores to Discriminate
Patients with a Broadly-defined Psychotic Disorder
Stella Calafato, Siri Ranlund, Alvaro Diez, Johan Hilge Thygesen, Marta Di Forti,
Cathryn Lewis, Robin Murray, John F. Powell, Rene S. Kahn, MJ Arranz, Conrad
Osamede Iyegbe, Dan Rujescu, Kuang Lin, Andrew McIntosh, Elvira Bramon, Andrew
McQuillin
Su68. Dendritic Spine Morphology is Altered in Human Induced Pluripotent
Stem Cell (iPSC) Derived Neurons with Chromosome 15q11.2 Deletions
Dhanjit Das, Kodavali Chowdari, Lily Francis, Leonardo D’Aiuto, Joel Wood, Ayantika
Ghosh, Vishwajit Nimgaonkar
Su69. Rare Bipolar Loci Identification Through Whole Exome Sequencing
Mehdi Pirooznia, Fernando Goes, Jennifer Parla, Melissa Kramer, Eric Monson,
Shizhong Han, Dubravka Jancic, Rachel Karchin, Virginia Willour, William McCombie,
James Potash, Peter Zandi
Su70. The Heritability of the General Psychopathology Factor in Children
Henning Tiemeier, Alexander Neumann, Marinus Van Ijzendoorn, Benjamin Lahey,
Frank Verhulst
Su71. BioVUpsych: Electronic Medical Record-based Identification of DNA
Samples for Disorders Underrepresented in the PGC
Takahiro Soda, James Crowley, Gerome Breen, Cynthia Bulik, Sarah Collier, Joshua
Denny, Kayla Howell, Kerstin Lindblad-Toh, Patrick Sullivan
Page 103
POSTERS
Su72. Anxiety, ADHD, and Epilepsy in a Male Patient with Pathogenic PCDH19
Gene Variant Mosiacism
Sarah Soden, Isabelle Thiffault, Benjamin Black, Jennifer Lowry, Laurie Smith, Emily
Farrow, Neil Miller, Carol Saunders
Su73. Unraveling the Exological Pathways Underlying the Comorbidy between
Developmental Dyslexia and Attention Deficit/Hyperactivity Disorder
Cecilia Marino, Sara Mascherettim, Vittoria Trezzi, Robert Giorda
Su74. Pathway Analysis on Whole Genome Data for Gilles de la Tourette
Syndrome Implicates TCF3
Fotis Tsetsos, John Alexander, Dongmei Yu, Jae Hoon Sul, Ivette Zelaya, Giovanni
Coppola, Petros Drineas, Carol Mathews, Jeremiah Scharf, Peristera Paschou
PHARMACOGENETICS
Su75. Meta-analysis of Catechol-O-Methyltransferase (COMT) Val158Met in
Relation to Antipsychotic Response in Schizophrenia-spectrum Disorders
Eric Huang, Clement Zai, Amanda Lisoway, Malgorzata Maciukiewicz, Daniel Felsky,
Arun K. Tiwari, Jeffrey R. Bishop, Masashi Ikeda, Patricio Molero, Stefano Porcelli,
Herbert Y. Meltzer, Jeffrey A. Lieberman, Steven G. Potkin, Daniel J. Müeller, James L.
Kennedy
Su76. Genome-wide Association Study in Duloxetine and Placebo Response
Daniel Müeller, Malgorzata Maciukiewicz, Victoria Marshe, Arun K. Tiwari, Trehani
Fonseka, Natalie Freeman, Susan Rotzinger, Jane A. Foster, James L. Kennedy,
Sidney Kennedy
Su77. Genetic Contributions to Cardiovascular Tolerability of ADHD
Pharmacotherapy
Erika Nurmi, Lauren Seaman, Christopher Laughlin, Gerhard Hellemann, James
McGough, James McCracken
Su78. Examining Variation in the Dopamine Receptor Genes (DRD1-5) with
Regards to Antipsychotic Treatment Response in a South African First
Episode Schizophrenia Cohort
Kevin O’Connell, Nathaniel McGregor, Christine Welham, Louise Warnich
Su79. Investigating the Functional Significance of Genome-wide Variants
Associated with Antipsychotic Treatment Response in Schizophrenia
Ellen Ovenden, Britt Drögemöller, Lize van der Merwe, Robin Emsley, Louise Warnich
Su80. The Inflammatory Cytokines as Biomarkers for the Prediction of
Antidepressant Response
Timothy Powell, Hong Wang, Raymond Chung, Aoife Keohane, David Collier, Gerome
Breen
Page 104
POSTERS
Su81. Genetic and Molecular Mechanisms in Lithium-associated Renal Disease:
A Systematic Review
Soham Rej, Shamira Pira, Victoria Marshe, Dominique Elie, Karl Looper, Nathan
Herrmann, Daniel Müeller
Su82. Open Board
Su83. Convergent Analysis of Transcriptome and Genome-wide Genotyping
Data Suggests the Involvement of Zinc-finger Genes in Modulating
Lithium Response in Patients with Bipolar Disorder
Alessio Squassina, Claudia Pisanu, Paola Niola, Giovanni Severino, Raffaella Ardau,
Caterina Chillotti, Maria Del Zompo
Su84. Establishing the Characteristics of an Effective Pharmacogenetic Test for
Clozapine Induced Agranulocytosis
Moira Verbelen, David Collier, Dan Cohen, James McCabe, Cathryn Lewis
SCHIZOPHRENIA
Su85. Transcriptome-wide Mega-analyses Reveal Joint Dysregulation of
Immunologic Genes and Transcription Regulators in Brain and Blood in
Schizophrenia
Jonathan Hess, Daniel Tylee, Rahul Barve, Simone de Jong, Paul Tooney, Nishantha
Kumarasinghe, Roel Ophoff, Stephen Glatt
Su86. Exome Sequencing Identifies a Compound Heterozygous Mutation in a
Gene from Histone Methyl Transferase Complex in Familial Schizophrenia
Jibin John, Prachi Kukshal, Triptish Bhatia, Smita N. Deshpande, Vishwajit L.
Nimgaonkar, B. K. Thelma
Su87. Runs of Homozygosity in the PGC2 Data – No Reliable Association with
Schizophrenia
Emma Johnson, Daniel Howrigan, Matthew Keller, Douglas Bjelland
Su88. Polygenic Overlap Between Schizophrenia and Psychopathology in the
General Population
Hannah Jones, Evie Stergiakouli, Katherine Tansey, Leon Hubbard, Jon Heron, James
Walters, George Davey Smith, Michael O’Donovan, Michael Owen, Stanley Zammit
Su89. Effects of Polygenic Risk Scores for Schizophrenia on Psychosocial
Functioning Within and Across Diagnostic Boundaries
Janos Kalman, Urs Heilbronner, Sergi Papiol, Dörthe Malzahn, Jana Strohmaier, Maren
Lang, Josef Frank, Jens Treutlein, Andrea Hofmann, Franziska Degenhardt, Stephanie
Witt, Sven Cichon, Markus Nöthen, Marcella Rietschel, Thomas Schulze
Page 105
POSTERS
Su90. Differential Splicing Analyses in Large Cohort of Schizophrenia Brains
David Kavanagh, Menachem Fromer, CommonMind Consortium
Su91. Are COMT-Val158Met and BDNF-Val66Met Polymorphisms Associated
with Psychotic Experiences and Clinical Psychosis Outcome? Evidence
from a Prospective Population-based Cohort, 2008-2015.
Umut Kirli, Hayriye Elbi, Tolga Binbay, Koksal Alptekin, Bulent Kayahan, Nesli Zagli,
Huseyin Onay, Ferda Ozkinay, Kubra Yildirim, Duygu Keskin, Jim Van Os
Su92. Association of the ZNF804A Candidate Gene with Symptom Severity and
Neurocognition in Patients with Schizophrenia and Healthy Controls in a
Hungarian Sample
Izabella Klein, Judit Benkovits, Katalin Szőcs, Kinga Farkas, Patrícia Polgár, Attila
Pulay, János Réthelyi
Su93. Association of a Promoter SNP rs60266355 of TAAR1 in a North Indian
Schizophrenia Cohort
Prachi Kukshal, Jibin John, Triptish Bhatia, Vishwajit Nimgaonkar, Smita N.
Deshpande, B. K. Thelma
Su94. Modifier Loci Associated with Age-at-onset and Neurocognitive Function
of Schizophrenia in Multiplex Families
Jia-Ying Lee, Po-Chang Hsiao, Po-Hsiu Kuo, Yin-Ju Lien, Shi-Heng Wang, Chih-Min
Liu, Hai-Gwo Hwu, Chien-Hsiun Chen, Jer-Yuarn Wu, Wei J. Chen
Su95. Evidence for Genetic Overlap Between Schizophrenia and Maternal Age
at First Birth
Divya Mehta, Felix Tropf, Jacob Gratten, Silviu Bacanu, Andrew Bakshi, Psychiatric
Genomics Consortium Schizophrenia, Bryan Mowry, Kenneth Kendler, Jian Yang,
Peter Visscher, John McGrath, Melinda Mills, Naomi Wray, Sang Hong Lee
Su96. Joint Analysis of CLOZUK and Swedish Exome Chip Datasets in
Schizophrenia
Ganna Leonenko, Alexander Richards, Peter Holmans, James Walters, Patrick
Sullivan, Sweden Schizophrenia Study, Benjamin Neale, Kimberly Chambert, Michael
Owen, Michael O’Donovan
Su97. Common and Distinct Genetic Risks for Schizophrenia and Bipolar
Disorder
Jingyu Liu, Jiayu Chen, Nora Perrone-Bizzozero, Jessica Turner, Vince Calhoun
Su98. Functional Study of a Novel Homozygous Mutation in the GAD1 Gene,
Detected in a Patients with Schizophrenia
Chiara Magri, Edoardo Giacopuzzi, Alessandro Barbon, Luca La Via, Chiara Congiu,
Flavia Orizio, Sergio Ferraboli, Roberto Bresciani, Giuseppe Borsani, Emilio Sacchetti,
Massimo Gennarelli
Page 106
POSTERS
Su99. Genetic Risk for Schizophrenia Associated with Non-participation over
Time in a Population-based Cohort Study
Joanna Martin, Kate Tilling, Leon Hubbard, Evangelia Stergiakouli, Michael
O’Donovan, George Davey Smith, Anita Thapar, Stanley Zammit
Su100. The Genetic Overlap Between Schizophrenia and Childhood
Psychopathology
Christel M. Middeldorp, Michel Nivard, Suzi Gage, Jouke-Jan Hottenga, Toos van
Beijsterveldt, Bart Baselmans, Lannie Ligthart, Beate St Porcain, Marcus Munafo,
Dorret Boomsma
Su101. Single Nucleotide Polymorphism of the FK506-binding Protein 51 (FKBP5)
Gene is Associated with Increased Risk for Psychosis and Impaired
Social Cognition in a Serbian Population
Marina Mihaljevic, Sanja Andric, Tijana Mirjanic, Ivana Novakovic, Nadja Maric Bojovic
Su102. Searching for a Burden of Rare Functional Mutations in 2300
Schizophrenia Cases and 2300 Controls by the Exon Sequence of 187
Schizophrenia Candidate Genes
Noa Carrera, Joanne Morgan, Elliot Rees, Kirsty Hambridge, Lyudmila Georgieva,
David Kavanagh, Kiran Mantripragada, George Kirov, Michael Owen, Michael
O’Donovan
Su103. Genome-wide Association Study of Schizophrenia in the Iban of Sarawak
Reveals Genetic Overlap with Han Chinese and, to a Lesser Extent,
Europeans
Sathish Periyasamy, Robert Barrett (deceased), Weihua Yue, Jacob Gratten, Deborah
Nertney, Duncan McLean, Heather Smith, Cheryl Filippich, Peter Loa, Schizophrenia
Working Group of the Psychiatric Genomics Consortium, Dai Zhang, Robert Yolken,
Bryan Mowry
Su104. Open Board
Su105. Via 7: The Danish High Risk and Resilience Study. A Cohort Study of 500
7 Year Old Children Born of Parents Diagnosed with either Schizophrenia,
Bipolar Disorder or Neither of these Two Mental Disorders
Merete Nordentoft, Kerstin von Plessen, Anne Thorup, Jens Richard Jepsen, Ole Mors
Su106. Expression Profiles and Cognitive Function as a Predictive Biomarker of
Schizophrenia: A Pilot Study
Yuko Okahisa, Shinji Sakamoto, Manabu Takaki, Norihito Yamada
Su107. Increased Diversity in Blood Microbiome in Schizophrenia
Loes Olde Loohuis, Serghei Mangul, Anil Ori, Guillaume Jospin, Rita Cantor, Jonathan
Eisen, Rene S. Kahn, Eleazar Eskin, Roel Ophoff
Page 107
POSTERS
Su108. CACNA1C Gene and Schizophrenia: A Case-control and
Pharmacogenetic Study Short Title: CACN1C Gene and Schizophrenia
Stefano Porcelli, Soo-Jung Lee, Changsu Han, Ashwin A. Patkar, Alessandro Serretti,
Chi-Un Pae
Su109. Hot Genes in Schizophrenia: Case-control, Pharmacogenetics and
Exploratory Analyses in Two Independent Samples
Stefano Porcelli, Soo-Jung Lee, Changsu Han, Ashwin A. Patkar, Diana De Ronchi,
Anna Rita Atti, Alessandro Serretti, Chi-Un Pae
Su110. Investigating Epigenomic Regulation in Schizophrenia
Joana Viana, Ruth Pidsley, Eilis Hannon, Helen Spiers, Claire Troakes, Safa Al-Saraj,
Naguib Mechawar, Gustavo Turecki, Leo Schalkwyk, Nicholas J. Bray, Jonathan Mill
SUBSTANCE ABUSE
Su111. A Highly Polymorphic Copy Number Variant in the NSF Gene is
Associated with Cocaine Dependence
Judit Cabana-Domínguez, Carlos Roncero, Lara Grau-López, Elena Ros-Cucurull,
Nieves Martínez-Luna, Núria Voltes, Constanza Daigre, Gemma Prat, Nathan E.
Wineinger, Galina Erikson, Josep Antoni Ramos-Quiroga, Miquel Casas, Marta
Ribasés, Bru Cormand, Noèlia Fernàndez-Castillo
Su112. Identification of Novel Genetic Loci for Heroin Abuse in a Genome-wide
Association Study in a Han Chinese Sample
Jack Euesden, Gursharan Kalsi, Jonathan Coleman, Francesca Ducci, Fazil Aliev,
Stephen Newhouse, Xiehe Liu, Xiaohong Ma, Yingcheng Wang, David Collier, Philip
Asherson, Tao Li, Gerome Breen
Su113. Identification and Characterization of Haplotypes of DRD2 and ANKK1
Genes in Addiction Disorders
Anna Grzywacz, Andrzej Jasiewicz, Mariusz Sznabowicz, Beata Karakiewicz, Joanna
IskraTrifunović, Iwona Małecka, Jerzy Samochowiec
Su114. Multimarker Scoring Routines Based on P300 Neuroelectrical
Measurements Show Association with Alcohol Dependence in
Independent Subjects, with Significant Enrichment in Axon Guidance
Pathways
Mark Kos, Laura Bierut, Bernice Porjesz, Laura Almasy, COGEND Authors, COGA
Authors
Su115. CNR1 and Faah Variation and Affective States Induced by Marijuana
Smoking
Rohan Palmer, John McGeary, Valerie Knopik, Jane Metrik
Page 108
POSTERS
Su116. Shortened Telomeres, Maltreatment, Stress-related SNPs and their
Relationships with Depressive Symptoms During Detoxification
Treatment of Crack/Cocaine Addicts
Diego Rovaris, Bruna da Silva, Djenifer B. Kappel, Angelita P. Aroche, Nina R. Mota,
Saulo G. Tractenberg, Mateus L. Levandowski, Lucas B. Rizzo, Pawan Maruya, Elisa
Brietzke, Claiton H.D. Bau, Rodrigo Grassi-Oliveira
Su117. Role of Rare DNA Variants in the Genetic Aetiology of ADHD
Ziarih Hawi, Tarrant Cummins, Janette Tong, Qiongyi Zhao, Naomi Wray, Miachael Gill,
Mark Bellgrove
Su118. Conduct Problems Link Attention-Deficit/Hyperactivity Disorder to
Substance Use Disorder
Gido Schoenmaker, Elena Sokolova, Tom Claassen, Annabeth Groenmann, Tom
Heskes, Alejandro Arias-Vásquez, Jan Buitelaar
Page 109
POSTERS
ADHD
M1.
Gut Microbiome in ADHD and its Relation to Brain Function
Alejandro Arias-Vásquez, Esther Aarts, Tom Everdeen, Jilly Naaien, Marcel Zwiers, Jos
Boekhorst, Harro Timmerman, Jeffrey Glennon, Barbara Franke, Roshan Cools, Jan
Buitelaar, Sacha van Hijum
A Genome-wide Sibling Transmission Disequilibrium Analysis with
Attention-Deficit/Hyperactivity Disorder in Korean Youths
Yuree Kang, Yuree Kang, Kukju Kweon, Eun-soon Shin, Yeonho Joo, Hyo-won Kim
M2.
A Genome-wide Association Analysis of Attention-Deficit/Hyperactivity
Disorder in Korean Youths
Kukju Kweon, Eun-soon Shin, Yeon Ho Joo, Hyo-Won Kim
M3.
Dopamine Receptor DRD4 Gene and Stressful Life Events in Persistent
Attention-Deficit/Hyperactivity Disorder
Cristina Sanchez-Mora, Vanessa Richarte, Iris Garcia-Martínez, Mireia Pagerols,
Montse Corrales, Rosa Bosch, Raquel Vidal, Laia Viladevall, Miguel Casas, Bru
Cormand, Josep Antoni Ramos-Quiroga, Marta Ribasés
M4.
Separating the Wheat from the Chaff: Systematic Identification of
Functionally Relevant Noncoding Variants in ADHD
Janette Tong, Ken Pang, Mark Bellgrove, Ziarih Hawi
M5.
AFFECTIVE DISORDERS
Meta-analysis of Whole Blood Gene Expression in Major Depression:
Identifying Coherent Gene Networks
Sara Mostafavi, Rick Jansen, Alexis Battle, Xiaowei Zhu, Jianxin Shi, Stephen
Montgomery, Alexander Urban, Myrna Weissman, James Potash, Gerard van
Grootheest, Johannes Smit, Patrick Sullivan, Douglas Levinson, Brenda Penninx
M6.
Possible Role of Methylenetetrahydrofolate Reductase C677T Genetic
Polymorphism in Modulating the Antidepressant and Anxiolytic Response
to Deep-transcranial Magnetic Stimulation
Ryan Nathan, Zia Choudhry, Walter Duffy, Mohammed Waris, Waquar Siddiqui,
Mahesh Rajamani
M7.
Genome-wide Methylation Analysis of Depression in the Japanese
Population
Takeshi Otowa, Mihoko Shimada-Sugimoto, Taku Miyagawa, Yoshiya Kawamura,
Chihiro Kakiuchi, Tadashi Umekage, Kiyoto Kasai, Katsushi Tokunaga, Tsukasa Sasaki
M8.
= ECIP Travel Award
Page 110
POSTERS
Polygenic Risk Scores in BMI and Depression Subtypes (Typical and
Atypical)
Margarita Rivera, Carol Kan, Radiant Depression Consortium, Khalida Ismail, Gerome
Breen, Anne Farmer, Peter McGuffin, Cathryn Lewis
M9.
Interactions Between Mitochondrial and Nuclear Single Nucleotide
Polymorphisms Modify Risk of Bipolar Disorder
Euijung Ryu, Malik Nassan, Gregory Jenkins, Ana Andreazza, Susan McElroy, Mark
Frye, Joanna Biernacka
M10.
A Mendelian Randomization Investigation of the Causal Relationship
Between IL-6 and Adolescent Depression
Hannah Sallis, Golam Khandaker, Jonathan Evans, Lavinia Paternoster, George Davey
Smith
M11.
Validity of a Self-rating Questionnaire for Major Depressive Disorder:
Comparison with Clinical Interview Data
Jessica Martin, Fabian Streit, Jens Treutlein, Maren Lang, Josef Frank, Andreas J.
Forstner, Franziska Degenhardt, Stephanie Witt, Thomas Schulze, Sven Cichon,
Markus Noethen, Marcella Rietschel, Jana Strohmaier
M12.
Telomere Length in Children with Cognitive Vulnerability to Depression in
Childhood
Aditi Thakur, Morgan Kleiber, Haroon Sheikh, Shiva Singh, Elizabeth Hayden
M13.
Addressing Rare Variant Contributions to the Genetic Architecture of
Bipolar Disorder, Utilizing Extended Families with Highly Penetrant Forms
of Illness
Claudio Toma, Alex D. Shaw, Richard Allcock, Philip Mitchell, Peter Schofield, Janice
Fullerton
M14.
Elevation of Il6 is Associated with Disturbed let-7 Biogenesis in a Genetic
Model of Depression
Yabin Wei, Jiajia Liu, Elin Åberg, Stefen Brené, Gregers Wegener, Aleksander Mathe,
Catharina Lavebratt
M15.
Impact of Polygenetic Loading for Schizophrenia on Cognition and Trait
Features of Depression in a Large Population-based Cohort
Heather Whalley, Toni Clarke, Mark Adams, Lynsey Hall, Ana Maria Fernandez, Jude
Gibson, Eleanor Wigmore, Caroline Hayward, Stephen M. Lawrie, Chris S. Haley,
David Porteous, Ian J. Deary, Andrew McIntosh
M16.
Genetic Investigation of Appetitive Aggression in South African Former
Young Offenders: The Involvement of Serotonin Transporter
Khethelo Xulu, Jessica Sommer, Martina Hinsberger, Roland Weierstall, Thomas Elbert,
Soraya Seedat, Sian Hemmings
M17.
Page 111
POSTERS
Pathway and Regional Heritability Analysis Identifies Pathways
Associated with Major Depressive Disorder
Yan-ni Zeng, Pau Navarro, Ana M. Fernandez-Pujals, Lynsey S. Hall, Toni-Kim Clarke,
Pippa A. Thomson, Blair H. Smith, Sandosh Padmanabhan, Caroline Hayward, Donald
J. MacIntyre, Major Depressive Disorder Working Group of the Psychiatric GWAS
Consortium, David J. Porteous, Ian J. Deary, Chris S. Haley, Andrew M. McIntosh
M18.
ANXIETY DISORDER
A Common Rora Variant is Associated with Traumatic Memories in
Genocide Survivors and with Aversive Memory in Non-traumatized
Individuals
Angela Heck, Sarah Wilker, Vanja Vukojevic, Klara Spalek, Iris Kolassa, Dominique J.F.
de Quervain, Andreas Papassotiropoulos
M19.
AUTISM
Identification of Candidate Autism Genetic Variants Including a
Heterozygous Stop-gain Mutation in ASXL3 that Refines Autism
Spectrum Disorder Diagnosis to Bainbridge-Ropers Syndrome
Brendan Swan, Jessie Jacobsen, Juliet Taylor, Rosamund Hill, Klaus Lehnert, Russell
Snell
M20.
Coexpression Network of Putative Target Genes from Sexual
Chromosomes Proteins (SOX3 and SRY) is Disrupted among Autism and
Control Samples
Ana Tahira, Bianca Lisboa, Ana Cecilia Feio dos Santos, Viviane Reis, Helena Brentani
M21.
M22.
Open Board
RNA Sequencing of Transformed Lymphoblastoid Cells from Siblings
Discordant for Autism Spectrum Disorders Reveals Transcriptomic and
Functional Alterations: Evidence for Sex-specific Effects
Daniel Tylee, Alfred Espinoza, Sarah McCoy, Stephen Glatt
M23.
Investigating Functional Impact of Autism Splice Site Mutations on
Isoform-level Co-expressed and Interacting Network
Jorge Urresti, Guan Ning Lin, Hyun-Jun Nam, Lilia Iakoucheva
M24.
Screening for Mutations in Non-syndromic Autosomal Recessive
Intellectual Disability Genes in Non-consanguineous Intellectual Disability
and Autism Populations
John Vincent, Ricardo Harripaul, Larysa Santavy, Amy NcNaughton, Kirti Mittal, Nasim
Vasli, Anna Mikhailov, Cameron Henry, Melissa Hudson, Christian Windpassinger,
James Stavropoulos, Melissa Carter, Pornprot Limprasert, Muhammad Ayub, Xudong
Liu
M25.
Page 112
POSTERS
An Investigation of X-chromosome Inactivation Profiles using a
Genetically Sensitive Discordant Twin Design
Baocong Xia, Agnieszka Kepa, Emma Colvert, Emma Meaburn, Angelica Ronald,
Leonard Schalkwyk, Jonathan Mill, Robert Plomin, Francesca Happé, Chloe Chung Yi
Wong
M26.
BIOSTATISTICS / BIOINFORMATICS
Investigating Quantitative Phenotype-genotype Associations in
Alzheimer’s Disease using Gene Ontology
Sejal Patel, Min Tae M. Park, Mallar M. Chakravarty, Jo Knight
M27.
The Potential Impact of Falsely Classified Controls on the SNP-based
Heritability of Depression
Wouter J Peyrot, Brenda Penninx, Naomi Wray
M28.
Comprehensive Comparative Performance Analysis of High-density
Oligomer Array Platforms for the Detection and Analysis of Human
Genomic Copy Number Variation
Rajini Haraksingh, Alexej Abyzov, Alexander Urban
M29.
Using Machine Learning Algorithms to Attempt to Uncover Complex
Interactions in Treatment Resistant Schizophrenia
Timothy Vivian-Griffiths, Andreas Artemiou, James T. R. Walters, Jennifer Moran,
Steven McCarroll, Michael O’Donovan, Michael Owen, Andrew Pocklington, Valentina
Escott-Price
M30.
Genetic Correlations Between Major Depressive Disorder and Other
Disorders
Qingqing Xu, Rebecca Harrison, Cathryn Lewis, Paul O’Reilly, Gerome Breen
M31.
Cross Disorder Genetic Analysis of Tourette’s Syndrome, Obsessive
Compulsive Disorder and Hoarding
Nuno Zilhao
M32.
ELSI, COUNSELING AND GENETICS TESTING
The Danish Cytogenetic Central Register: Population-based Survival
Analysis of Mental Disorders among Carriers of Chromosomal
Abnormalities
Louise Hoeffding, Betina B. Trabjerg, Anders Vangkilde, Line Olsen, Carsten B.
Pedersen, Thomas Werge, Wiktor Mazin
M33.
M34. Perceptions of Psychiatric Genetic Counselling Within the UK
Rosa Spencer Tansley, Jehannine Austin, Kevin McGhee
Page 113
POSTERS
The Diagnostic Odyssey: Barriers to Genetic Testing in UK Intellectual
Disability Psychiatry Services
Kate Wolfe, Andrew McQuillin, Andre Strydom, Giovanni Giaroli, Kerstin Stueber,
Nicholas Bass
M35.
ENDOPHENOTYPES
Binocular Rivalry Rate as a Novel Candidate Endophenotype for Bipolar
Disorder
Trung Ngo, Miguel E. Rentería, Lucia Colodro Conde, Baptiste Couvy-Duchesne,
Gabriel Cuellar-Partida, Narelle K. Hansell, Sarah E. Medland, Steven M. Miller,
Margaret J. Wright, Nicholas G. Martin
M36.
M37.
Open Board
A Polygenic Risk Score Reflecting Genetic Variation in Neuronal Calcium
Signaling Loci Associated with Schizophrenia Interacts with Schizotypy
in Predicting Working Memory and Related Prefrontal Cortex Activity in
Healthy Humans
Antonio Rampino
M38.
Independent and Interactive Effects of CNTNAP2 on Rapid Auditory
Processing in 6-month-old Italian Infants
Valentina Riva, Chiara Cantiani, Caterina Piazza, April Benasich, Massimo Molteni,
Ginette Dionne, Cecilia Marino
M39.
Redesign of the Classic N-back Working Memory Task as an Applied
Game
Christian Vogler, Andreas Aeberhard, Leo Gschwind, Tobias Egli, Janson
Cheeramkunnel, Ferya Gecen, Matthias Hug, David Hochuli, Shahab Jahanabadi,
Tobias Kohler, Joep Neijt, Sulamith Schläppi, Annika Winterhalter, Dominique J.F. de
Quervain, Andreas Papassotiropoulos
M40.
Shared Genetic Architecture between Cognition and Regional Brain
Volume
Eleanor Wigmore, Toni Clarke, Kristin Nicodemus, Andrew McIntosh
M41.
Page 114
POSTERS
EPIGENETICS
Methylation Quantitative Trait Loci (mQTL) in the Developing Human Brain
and their Enrichment in Genomic Regions Associated with Schizophrenia
Eilis Hannon, Helen Spiers, Joana Viana, Ruth Pidsley, Joe Burrage, Therese Murphy,
Claire Troakes, Gustavo Turecki, Michael O’Donovan, Leonard Schalkwyk, Nicholas J.
Bray, Jonathan Mill
M42.
M43. An Integrated Genetic-epigenetic Analysis of Schizophrenia
Eilis Hannon, Emma Dempster, Joe Burrage, Adam Smith, Hugh Gurling, Nicholas
Bass, Andrew McQuillin, Leo Schalkwyk, Jonathan Mill
The Influence of SNPS in the 50mer Probe Sequences of the Illumina
450K Bead-chip Array on mQTLs in Cis
Annette Milnik, Christian Vogler, Tobias Egli, Virginie Freytag, Angela Heck, Dominique
J.F. de Quervain, Andreas Papassotiropoulos, Vanja Vukojevic
M44.
Histone Deacetylase and Histone Acetyltransferase Activities are Altered
in Major Depressive Disorder and Bipolar Patients – No Change during
Short-term Treatment
Richard Musil, Johanna Dobmeier, Johannes Dorr, Rebecca Schennach, Sylvia de
Jonge, Peter Zill
M45.
Epigenetic Alterations Through Surgery and Postoperative Delirium: Pilot
Study
Ryoichi Sadahiro, Knight Bridget, Neil Smart, John Charity, Aaron Jeffries, Joe
Burrage, Eilis Hannon, Emma Dempster, Therese Murphy, Katie Lunnon, Jonathan Mill
M46.
DNA Hydroxymethylation Associated with Human Fetal Brain
Development
Helen Spiers, Eilis Hannon, Leo Schalkwyk, Nick Bray, Jonathan Mill
M47.
Identification of Epigenetic Variants Associated with Neuropsychiatric
Disorders in Perinatal and Postmortem Tissue Applying Agnostic and
Genome-wide Methodologies
Nicklas Staunstrup, Anna Starnawska, Anders Nielsen, Stine Bak, Marit Nielsen, Mette
Nyegaard, Mads Hollegaard, Jørn Olsen, Carsten Obel, Niels Bilenberg, Maj Vinberg,
Karl-Anton Dorph-Petersen, Jens Nyengaard, Anders Børglum, Ole Mors
M48.
Implications of DNA Methylation for PTSD: From Gene-specific to
Genome-wide and Biological Aging Patterns
Vanja Vukojevic, Annette Milnik, Dominique J.F. de Quervain, Andreas
Papassotiropoulos
M49.
= ECIP Travel Award
Page 115
POSTERS
FUNCTIONAL GENOMICS & MODEL ORGANISMS
M50. D. Melanogaster
Kevin McGhee, Lisha Ma
The Ankryin 3 Bipolar Disorder Risk Gene Regulates Mood-related
Behaviors by Modulating Hippocampal Function
Tracey Petryshen, Jacob Garza, Klaudio Gjeluci, Melanie Leussis
M51.
Functional Analyses of an Evolutionarily Conserved Region Downstream
of the Melanocortin 4 Receptor (MC4R) Gene Associated with
Li Qin, Natalie Freeman, James L. Kennedy, Daniel Müeller
M52.
Genetic and Neuroendocrinological Biomarkers in Anorexia Nervosa and
Relatives
Nicolas Ramoz, Audrey Versini, Dominique Grouselle, Sophie Criquillion-Doublet,
Frédéric Rouillon, Jacques Epelbaum, Philip Gorwood
M53.
M54. Copy Number Variation Analysis of a Finnish Cohort of Criminal Offenders
Marja-Riitta Rautiainen, Jari Tiihonen, Virpi Leppä, Olli Pietilainen, Jari Lahti, Johanna
Liuhanen, Eila Repo-Tiihonen, Johan Eriksson, Matti Virkkunen, Aarno Palotie, Tiina
Paunio
M55. Estradiol Induces Epression of PTSD-associated Gene ADCYAP1R1
(PAC1) Through the Interation of ERalpha at an Estrogen Response Element
Kristina Mercer, Stephanie Maddox, Brian Dias, Jordon Walton, Kerry Ressler
Analysis of the Genetic Overlap of Borderline Personality Disorder and
Bipolar Disorder
Stephanie Witt, Josef Frank, Jens Treutlein, Stefanie Heilmann, Andreas J. Forstner,
Thomas Muehleisen, Franziska Degenhardt, Christian Schmahl, Nikolaus Kleindienst,
Martin Bohus, Bjoern Schott, Stefan Roepke, Dan Rujescu, Markus Noethen, Marcella
Rietschel
M56.
Genetic Architecture for Human Aggression- A Study of Gene-phenotype
Relationship in OMIM
Yanli Zhang-James, Stephen Faraone
M57.
NEUROIMAGING
Impact of OLIG2 Gene Variant (rs1059004) on White Matter Tract Integrity
and Mean Cerebral Blood Flow of the Human Brain
Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Akira Kodaka, Shunichi Funakoshi,
Takashi Ono, Yoshihisa Kakuto, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita
M58.
Page 116
POSTERS
The Brain-derived Neurotrophic Factor Val66Met Polymorphism is
Associated with Altered Amygdala-cortical Structural Co-variance in
Adolescence
Anne Wheeler, Daniel Felsky, Joseph Viviano, Arash Nazeri, Jason Lerch, Mallar M.
Chakravarty, Aristotle Voineskos
M59.
OTHER
M60. APOE and Age-related Cognitive Change in a Longitudinal Cohort of Men
Ville Rantalainen, Jari Lahti, Markus Henriksson, Eero Kajantie, Pentti Tienari, Johan
Eriksson, Katri Räikkönen
Using Genealogy Clusters to Find High-penetrant Disease Variants in the
Danish Population
Anders Rosengren, Alfonso Buil, Marcelo Bertalan, Johan Hilge Thygesen, Preben Bo
Mortensen, Carsten B. Pedersen, Thomas Werge
M61.
Translational Correlation of MeCP2 Binding Dynamics and Clinical
Presentation of Male Patients with Missense Mutations
Taimoor Sheikh, Josh Silver, Alan Percy, John Vincent
M62.
M63. High Frequency of Genetic Syndromes in Neuropsychiatric Patients
Joyce So, Timothy Gofine, Hanna Faghfoury, Josh Silver, Jillian Murphy, James
Kennedy
M64. Early Life Stress, FKBP5 Polymorphisms and Type 2 Diabetes
Anna Suarez Figueiredo, Jari Lahti, Eero Kajantie, Johan Eriksson, Katri Räikkönen
Heritability and Shared Genetic Factors for Symptoms of Anxiety and
Depression in a Brazilian Family-based Cohort, the Baependi Study
Tâmara Taporoski, Andre Brooking Negrao, Andréa R.V.R. Horimoto, Núbia E. Duarte,
Rafael O. Alvim, Camila M. de Oliveira, José E. Krieger, Malcolm Von Schantz, Homero
Vallada, Alexandre C. Pereira
M65.
M66. ABO Blood Type and Personality Traits in Healthy Japanese Subjects
Norio Yasui-Furukori, Shoko Tsuchimine, Ayako Kaneda, Kazuhiko Nakamura, Junji
Saruwatari
Stress Response Genes and Hair Cortisol Levels in First Nation
Communities
Clement Zai, Julie George, David Irwin, Sajid Shaikh, Maria Tampakeras, David Sibony,
Michael Danesi, Natalie Freeman, Evan Russell, Jurgen Rehm, Stan van Uum, Gideon
Koren, Kathryn Graham, Samantha Wells, James L. Kennedy
M67.
Page 117
POSTERS
M68. Anorexia Nervosa Polygenic Risk Score: Preliminary Analyses
Stephanie Zerwas, Zeynep Yilmaz, Laura Thornton, Jack Eusden, Laramie Duncan,
Nadia Micali, Laura Huckins, Jessica Baker, Melissa Munn-Chernoff, James J.
Crowley, Sychiatric Genomics Consortium Anorexia Nervosa Working Group, Eleftheria
Zeggini, Gerome Breen, Cindy Bulik
An Integrated Molecular Landscape Implicates the Regulation of
Dendritic Spine Formation Through Insulin-related Signaling in
Obsessive-Compulsive Disorder
Ilse van de Vondervoort, Geert Poelmans, David Pauls, Jan Buitelaar, Jeffrey Glennon,
Barbara Franke
M69.
An Integrated Molecular Landscape for Tourette Syndrome Yields Novel
Clues for Diagnosis and Treatment
Joanna Widomska, Jan Buitelaar, Carol Mathews, Jeremiah Scharf, Geert Poelmans,
Jeffrey Glennon
M70.
Genetic Heterogeneity in a Consanguineous Pedigree with Intellectual
Disability and Autistic Features from Pakistan
Amelie Musa Johnson, Shu Li, Qin He, Sandra Laurent, Dan Spiegelman, Luise
Appeltshauser, Mehtab Christian, Zohair Nanjiani, Muhammad Qasim Brohi, Lan Xiong
M71.
M72. Genome-wide Analysis of Copy Number Variants in Anorexia Nervosa
Zeynep Yilmaz, Jin P. Szatkiewicz, Genetic Consortium for Anorexia Nervosa /
Wellcome Trust Case Control Consortium 3, Patrick F. Sullivan, Cynthia Bulik
PHARMACOGENETICS
Gene Expression Analysis of Clozapine Treatment in Whole Blood of
Patients with Psychosis
Rebecca Harrison, Robin Murray, Sang Hyuck Lee, Jose Paya Cano, David Dempster,
Charles Curtis, Danai Dima, Fiona Gaughran, Gerome Breen, Simone de Jong
M73.
Pharmacogenomics Analysis Identifies HLA-DRB1 as a Risk for
Lamotrigine-induced Cutaneous Adverse Drug Reactions in a Japanese
Population
Takeo Saito, Masashi Ikeda, Kenji Kondo, Ayu Shimasaki, Kohei Kawase, Hisashi Tanii,
Yukitoshi Takahashi, Ryota Hashimoto, Nakao Iwata
M74.
Genome-wide Association Study of Antidepressant Response:
Involvement of the Inorganic Cation Transmembrane Transporter Activity
Pathway
Chiara Fabbri, Enrico Cocchi, Changsu Han, Soo-Jung Lee, Ashwin A. Patkar, Prakash
S. Masand, Chi-Un Pae, Alessandro Serretti
M75.
Page 118
POSTERS
Neuroplasticity and Second Messenger Pathways in Antidepressant
Efficacy: Pharmacogenetic Results from a Prospective Trial Investigating
Treatment Resistance
Chiara Fabbri, Concetta Crisafulli, David Gurwitz, Julia Stingl, Raffaella Calati, Diego
Albani, Gianluigi Forloni, Marco Calabrò, Rosalba Martines, Siegfried Kasper, Joseph
Zohar, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Alessandro Serretti
M76.
M77. Genetics of Long-term Treatment Outcome in Bipolar Disorder
Chiara Fabbri, Alessandro Serretti
Exon-sequencing and Multi-omics Markers Reveal the Potential Role of
Nutrient-gene Interaction in Anorexia Nervosa
Pei-an Betty Shih, Jun Yang, Andrew Bergen, Ashley Van Zeeland, Wade Berrettini,
Pierre Magistretti, Katherine A. Halmi, Blake Woodside, Bruce German, Aaron
Armando, Oswald Quehenberger, Nicholas Schork, Walter Kaye, Bruce D. Hammock,
Christophe Morisseau
M78.
Analysis of Pharmacogenetic Studies: Comparing Traditional Statistical
Inference with Machine Learning
Moira Verbelen, Raquel Iniesta, David Collier, Michael Weale, Cathryn Lewis
M79.
The Identification of Novel Genetic Variants Associated with
Antipsychotic Treatment Response Outcomes in First Episode
Schizophrenia Patients
Britt Drögemöller, Robin Emsley, Bonginkosi Chiliza, Lize van der Merwe, Galen
Wright, Michelle Daya, Eileen Hoal, Anil Malhotra, Todd Lencz, Delbert Robinson,
Jianping Zhang, Laila Asmal, Dana Niehaus, Louise Warnich
M80.
Pharmacogenetics of Antidepressant Response in Obsessive-Compulsive
and Related Disorders
Gwyneth Zai, Carolina Cappi, Katharine Phillips, Vanessa Gonçalves, Clement Zai,
Roseli Shavitt, Euripedes Miguel, Margaret (Peggy) Richter, James L. Kennedy
M81.
Schizophrenia Risk Variant at DRD2 Locus Predicts Antipsychotic
Treatment Response in First Episode Psychosis
Jianping Zhang, Delbert Robinson, Juan Gallego, Yu Jin, John Kane, Anil Malhotra,
Todd Lencz
M82.
SCHIZOPHRENIA
Commonality and Specificity of Copy Number Variations in Schizophrenia
and Bipolar Disorder
Jiayu Chen, Vince Calhoun, Nora Perrone-Bizzozero, Jing Sui, Jessica Turner, Yuhui
Du, Jingyu Liu
M83.
Page 119
POSTERS
M84. High Loading of Polygenic Risk in Cases with Chronic Schizophrenia
Sandra Meier, Esben Agerbo, Robert Maier, Carsten B. Pedersen, Maren Lang,
Stephan Ripke, Thomas Werge, Ole Mors, David Hougaard, Anders Børglum,
Naomi Wray, Marcella Rietschel, Merete Nordentoft, Preben Bo Mortensen, Manuel
Mattheisen
Increased Mitochondria Content and Epigenetic Age Acceleration are
Independently Associated with Schizophrenia
Anil Ori, Loes Olde Loohuis, Timothy Wu, René S. Kahn, Steve Horvath, Roel Ophoff
M85.
Cell Type-specific Polygenic Risk Profiling in Schizophrenia and Bipolar
Disorder Patients
Sergi Papiol, Nirmal Raman Kannaiyan, Heike Anderson-Schmidt, Monika Budde,
Katrin Gade, Urs Heilbronner, Peter Falkai, Moritz J. Rossner, Thomas Schulze
M86.
A Simple Procedure to Incorporate Missing Data in the Estimation of
General Cognitive Ability
Antonio Pardiñas, Katherine Tansey, PGC-SCZ Cognition Group (COGIS), Gary
Donohoe, James T. R. Walters
M87.
M88. Molecular Characterization of Neurons in Pak7 Mutant Mice
Harish Ganipaneni Parvathaiah, Aiden Corvin, Daniela Tropea
Identification of Genetic Risk Variants in Regulatory Regions of Genes
Associated with Schizophrenia by Next Generation Sequencing
Javier Peñas, Mario Páramo, Eduardo Paz, Santiago Agra, Julio Brenlla, Luis Santomé,
Jorge Amigo, Beatriz Sobrino, Angel Carracedo, Manuel Arrojo, Javier Costas
M89.
Evidence for Shared Genetic Risk between Schizophrenia and Smoking
Behaviors: Initial findings from PGC2
Roseann Peterson, Tim Bigdeli, Kenneth Kendler, Ayman Fanous, Schizophrenia
Working Group Psychiatric Genomics Consortium
M90.
M91. Dysregulated 14-3-3 Family in Schizophrenia
Ying Qing, Chunling Wan
Schizophrenia Risk Variation on Chromosome 10q24 is Associated with
Altered cis-regulation of Multiple Genes in the Developing and Adult
Human Brain
Rodrigo Rafagnin Duarte, Claire Troakes, Matthew Nolan, Deepak P. Srivastava, Robin
Murray, Nicholas Bray
M92.
Analysis of De Novo Copy Number Variations in a Large, New
Schizophrenia Sample
Elliott Rees, Micha Gawlik, Megan Burton, Alexander Richards, EUGEI Consortium,
GROUP Consortium, Bart Rutten, Masashi Ikeda, Sarah Tosato, Celso Arango, Jim
Van Os, Peter Holmans, Michael Owen, George Kirov, Michael O’Donovan
M93.
Page 120
POSTERS
Examining the Roles of De Novo Mutations in LRRC7 and KHSRP by
Parallel Somatic Cell Reprogramming of a Schizophrenia Case-parent
Trio
János Réthelyi, Edit Hathy, Árpád Mike, Krisztina Pesti, Szilvia Szalóki, Gergő Vőfély,
László Homolya, Balázs Sarkadi, Ágota Apáti
M94.
M95. Sequencing Irish Multiplex Schizophrenia Pedigrees
Brien Riley, Bradley Webb, Brian Verrelli, Silviu Bacanu, Menachem Fromer, Patrick
Sullivan, Aiden Corvin, Kenneth Kendler, Irish Schizophrenia Genomics Consortium
Relations of Clinical Features in Schizophrenia and Polymorphism of
Neurotransmitter Serotonergic
Zoe Robaina, Beatriz Marcheco, Teresa Collazo, Manuel Gomez, Enny Morales,
Giessel Monzon, Evelín Fuentes, Lilia C. Marín, Antonio Caballero, Danys de las
Nieves Milian, Gina Galan, Yasmany Llanes, Jaime Valenti, Rafael Ventura, Ole Mors
M96.
The Genetic Architecture of Schizophrenia and Bipolar Disorder: An
Intriguing Puzzle of Loci and their Complex Interaction in a Closed
Population
Cecilia Salvoro, Carlo Campanelli, Livio Finos, Giorgio Valle, Maria Luisa Mostacciuolo,
Stefania Bortoluzzi, Giovanni Vazza
M97.
Genome-wide Expression and DNA Methylation Analysis in an
Antipsychotic-naive First Episode of Psychosis Cohort
Marcos Santoro, Vanessa K. Ota, Simone de Jong, Eduardo S. Gouvea, Patricia
Moretti, Leticia N. Spindola, Gabriela Xavier, Cristiano Noto, Quirino Cordeiro, Rodrigo
A. Bressan, Ary Gadelha, Gerome Breen, Sintia I. Belangero
M98.
Up-regulated MicroRNA miR-34a in Peripheral Blood of Patients
with Schizophrenia and Reelin as its Target Gene: Identification from
Algorithms and Validation in Reporter Gene Assays
Mu-Jung Shieu, Qi-Sheng Hong, Sung-Liang Yu, Chi-Yu Lai, Su-Yin Lee, Ya-Hui Yu,
Chih-Min Liu, Hai-Gwo Hwu, Wen-Mei Fu, Hsin-Yu Lee, Wei J. Chen
M99.
M100. Association Between Gene Expression and Schizophrenia: Assessing
Acute and Chronic Phases of the Disorder
Patricia Silva, Patricia Moretti, Vanessa Ota, Ary Gadelha, Cristiano Noto, Leticia
Spindola, Marcos Santoro, Eduardo Gouvea, Mariana Pedrini, Fernanda Talarico,
Gabriela Xavier, Elisa Brietzke, Jair Mari, Quirino Cordeiro, Rodrigo Bressan, Sintia
Belangero
M101. Burden of Copy Number Variants (CNVS) Implicated in Psychiatric and
Nonpsychiatricphenotypes in a Toronto Schizophrenia Population
Venuja Sriretnakumar, Clement Zai, Malgorzata Maciukiewicz, Joyce So, James L.
Kennedy
Page 121
POSTERS
M102. High-resolution Mapping of Genic CNVs that Confer Risk for
Schizophrenia
Jin Szatkiewicz, Stephanie Williams, Elliott Rees, Randy Nonneman, Sarah Bergen,
Exome Aggregation Consortium, Swedish Schizophrenia Consortium, Mikael Landen,
George Kirov, Michael O’Donovan, Michael Owen, Patrick Sullivan, Menachem Fromer,
Douglas Ruderfer, James Crowley
M103. Open Board
M104. Intergene SNP-SNP Interactions in DDR1 and Susceptibility to
Schizophrenia
Nerea Abasolo, Lourdes Martorell, Julio Sanjuan, Javier Costas, Sara Marsal, Antonio
Julià, Miriam Guitart Feliubadaló, Edith Pomarol-Clotet, Ana Gaviria, Elisabet Vilella
M105. Genome-wide Association Study in an Indian Population Reveals Genetic
Overlap for Schizophrenia with Europeans
Anna Vinkhuyzen, Sujit John, Sathish Periyasamy, Naomi Wray, Rangaswamy Thara,
Bryan Mowry
M106. Identification of Rare Disruptive Variants in Voltage-gated Channel Genes
(CACNA1C, CACNA1D, CACNA1S, CACNA1I) in Japanese Samples of
Schizophrenia and Autism Spectrum Disorder Using Ion Torrent PGM
Platform
Chenyao Wang, Hiroki Kimura, Jingrui Xing, Kanoko Ishizuka, Itaru Kushima, Yuko
Arioka, Akira Yoshimi, Yukako Nakamura, Yomoko Shiino, Yuko Oya, Yuto Takasaki,
Branko Aleksic, Daisuke Mori, Norio Ozaki
M107. Netrin Genetic Variation in Schizophrenia
James Wilcox, David Briones
M108. Risk Alleles for C-reactive Protein Appear to be Protective for
Schizophrenia
Anson Hei Man Wong, Schizophrenia Working Group of the Psychiatric Genomics
Consortium, Buhm Han, Soumya Raychaudhuri, Joanne Knight, Jennie Pouget
M109. Schizophrenia Susceptibility Gene CACNA1C Associates with
Microstructure of Fornix: A White Matter Brain Phenotype of
Schizophrenia with Function Related to Memory
Jingjing Zhao, Donna Cosgrove, Sinead Kelly, Aiden Corvin, Michael Gill, Dara
Cannon, Colm McDonald, Derek Morris, Gary Donohoe
Page 122
= ECIP Travel Award
POSTERS
SUBSTANCE ABUSE
M110. Transcripromic and Genetic Studies Identify NFAT5 as a Candidate Gene
for Cocaine Dependence
Noèlia Fernàndez-Castillo, Judit Cabana-Domínguez, Jordi Soriano, Cristina SánchezMora, Carlos Roncero, Lara Grau-López, Elena Ros-Cucurull, Constanza Daigre,
Marjolein M.J. van Donkelaar, Barbara Franke, Miguel Casas, Marta Ribasés, Bru
Cormand
M111. Case-control Study Analysis of DRD2 Gene Polymorphisms in Drug
Addicted Patients
Anna Grzywacz, Andrzej Jasiewicz, Mariusz Sznabowicz, Beata Karakiewicz, Joanna
IskraTrifunović, Iwona Małecka, Jerzy Samochowiec
M112. CYP2D6 Inactivating Polymorphisms may Protect Against Toxic
Methamphetamine Metabolite Formation and Resultant Cognitive
Dysfunction
Lauren Seaman, Erika Nurmi, Edythe London, Andy Dean
M113. Association Study of GABRA2 and GRIN2B Polymorphisms in Alcohol
Dependence
Bhagyalakshmi Shankarappa, Biju Viswanath, Sanjeev Jain, Prathima Murthy, Meera
Purushottam
M114. Dopaminergic Polymorphisms in Opiate Replacement Therapy of Heroin
Dependent Patients
Andrea Vereczkei, Agnes Szilagyi, Jozsef Csorba, Peter Sarkozy, Peter Antal, Zsolt
Demetrovics, Maria Sasvari-Szekely, Csaba Barta
Page 123
NOTES
Page 124
AUTHOR INDEX
Aarts, Esther
Abad, Alfonso
Abasolo, Nerea
Abdellaoui, Abdel
Åberg, Elin
Abyzov, Alexej
Ackerman, Benjamin
Adams, Mark
Adorjan, Kristina
Aeberhard, Andreas
Agerbo, Esben
Aggen, Steven
Agha, Sharifah Shameem
Agra, Santiago
Agrawal, Arpana
Ahn, Kwangmi
Ajnakina, Olesya
Akula, Nirmala
Albani, Diego
Alberry, Bonnie
Albus, Margot
Aleissa, Mariam
Aleksic, Branko
Alexander, John
Ali, Manir
Aliev, Fazil
Alizadeh, Behrooz Z.
Allcock, Richard
Allgulander, Christer
Almasy, Laura
Alonso, Pino
Alptekin, Koksal
Als, Thomas
Al-Saraj, Safa
Altar, Anthony C.
Alvarós, Joan
Alvim, Rafael O.
Amare, Azmeraw T.
Ambite, Jose Luis
Ament, Seth
Amigo, Jorge
Amri, Ahmed Al
Amunts, Katrin
An, Steven
Anderson-Schmidt, Heike
Andreazza, Ana
Andric, Sanja
Andrighetti, Heather
Antaki, Danny
Antal, Peter
Anttila, Verneri
Apáti, Ágota
Appeltshauser, Luise
Arango, Celso
Arasappan, Dhivya
Ardau, Raffaella
Arias-Vásquez, Alejandro
Arioka, Yuko
Arloth, Janine
110
93
122
14, 86
111
113
83
81, 111
93
114
120
96
95
120
93
99
90
82
85, 119
13, 14, 61
96
90
84, 122
104
92
108
88, 92
111
97
97, 108
87
92, 106
90, 97
108
89
93
117
88
87
68
120
14, 78
100
99
120
56, 111
107
99
84
123
13, 14, 79, 98
121
118
120
93
105
95, 109, 110
84, 122
13, 84
Armando, Aaron
Arnold, Paul
Aroche, Angelita P.
Arpawong, Thalida
Arranz, MJ
Arrojo, Manuel
Artemiou, Andreas
Asai, Tatsuro
Asherson, Philip
Asmal, Laila
Atkins, Joshua
Atti, Anna Rita
Austin, Jehannine
Ayub, Muhammad
Azeredo, Lucas
Bacanu, Silviu
Badcock, Johanna
Baggiani, Gioia
Bahl, Ethan
Bak, Stine
Baker, Jessica
Bakshi, Andrew
Balas, Antonio
Ballouz, Sara
Bani-Fatemi, Ali
Banlaki, Zsofia
Baranger, David
Barbon, Alessandro
Bares, Cristina
Barr, Cathy
Barral, Carmen
Barrett, Robert
Barrus, Michael
Barta, Csaba
Barve, Rahul
Baselmans, Bart
Bassett, Anne
Bass, Nicholas
Battle, Alexis
Bau, Claiton H.D.
Becerra-Palars, Claudia
Beckmann, S.
Beitchman, Joe
Belangero, Sintia
Bellgrove, Mark
Benasich, April
Bengesser, Susanne
Benkovits, Judit
Ben-Shachar, Dorit
Bergen, Andrew
Bergen, Sarah
Berlanga-Cisneros, Carlos
Bermingham, Mairead
Bernier, Raphael
Berrettini, Wade
Bertalan, Marcelo
Bertuzzi, Guilherme P.
Bevilacqua, Elizabeth
Bhatia, Triptish
Page 125
119
74, 98
82, 109
97
103
120
113
86
108
119
90
85, 108
23, 34, 57, 87, 99, 100, 113
112
81
91, 96, 106, 121
100
90
89
115
118
106
87
99
82, 86
13, 86
87
106
13, 93
7
93
107
47
123
98, 105
107
7, 87
90, 102, 114, 115
110
81, 82, 109
95
84
88, 97
95, 121
109, 110
100, 114
82
106
56
61, 85, 119
8, 66, 122
95
85
98
119
84, 117
82
91
105, 106
AUTHOR INDEX
Bidwell, Cinnamon
61
Biernacka, Joanna
80, 111
Bierut, Laura
59, 73, 93, 108
Bigdeli, Tim
46, 91, 96, 103, 120
Bilenberg, Niels
115
Binbay, Tolga
92, 106
Binder, Elisabeth
8, 84, 97, 101
Birner, Armin
82
Bishop, Jeffrey R.
104
Biskopstø, Marjun
90, 97
Bjelland, Douglas
105
Black, Benjamin
104
Blake, Derek
101
Blokland, Gabriëlla
85
Bocchetta, Alberto
90
Bocchio-Chiavetto, Luisella
96
Boehme, Kevin L.
85
Boekhorst, Jos
110
Bogdan, Ryan
87, 93
Bohus, Martin
116
Bojovic, Nadja Maric
107
Bolund, Lars
90
Bonvicini, Cristian
96
Boomsma, Dorret
86, 96, 107
Boot, Erik
87
Bordini, Daniela
98
Børglum, Anders
82, 83, 90, 97, 98, 115, 120
Borrmann-Hassenbach, Margitta 96
Borsani, Giuseppe
106
Bortolomasi, Marco
96
Bortoluzzi, Stefania
121
Bosch, Rosa
110
Bosio, Mattia
87
Bourgeron, Thomas
88
Boutros, Paul
86
Bralten, Janita
14, 69
Bramon, Elvira
103
Brandler, William
84
Brandli, Eva
89
Bray, Nicholas
101, 108, 115, 120
Breen, Gerome
45, 58, 61, 83, 86, 87, 90,
91, 100, 102, 103, 104, 108,
111, 113, 118, 121
Brené, Stefen
111
Brenlla, Julio
120
Brentani, Helena
86, 88, 95, 98, 103, 112
Bresciani, Roberto
106
Bressan, Rodrigo
95, 121
Bridget, Knight
115
Brietzke, Elisa
109, 121
Briones, David
122
Briones, Magdalena
88
Brohi, Muhammad Qasim
118
Brunner, Han
95
Brunoni, Décio
98
Bryushkova, Lyubov
88
Brzustowicz, Linda
87
Budde, Monika
14, 43, 120
Buil, Alfonso
117
Buitelaar, Jan
Bulik, Cynthia
Bulik-Sullivan, Brendan
Bundo, Miki
Burmeister, Margit
Burrage, Joe
Burton, Christie
Burton, Megan
Buttenschøn, Henriette
Byrd, Desiree
Byrne, Enda
Caballero, Antonio
Cabana-Domínguez, Judit
Cacioppo, John T.
Cai, Na
Cairns, Murray
Cai, Tianxi
Calabrò, Marco
Calafato, Stella
Calati, Raffaella
Calhoun, Vince
Camilo, Caroline
Campanelli, Carlo
Campbell, Archie
Campuzano, Victoria
Cannon, Dara
Cano, Jose Paya
Cantiani, Chiara
Cantillo, Miguel Ángel
Cantor, Rita
Cappi, Carolina
Capusan, Andrea Johansson
Cardno, Alastair G.
Carey, Caitlin
Caria, Paola
Carlsson, Arvid
Carr, Vaughan
Carracedo, Angel
Carreira, Luzia Lima
Carrera, Noa
Carrillo-Roa, Tania
Carroll, Adam
Carter, Melissa
Casas, Miguel
Caspers, Svenja
Castellani, Christina
Castrillo, Eduardo
Cath, Danielle
Cerrone, Kim
Chadha, Kartikay
Chakravarty, Mallar M.
Chambert, Kimberly
Chang, Jeffery
Chang, Xiao
Charity, John
Chaumette, Boris
Cheeramkunnel, Janson
Chen, Cheng
Chen, Chia-Yen
Page 126
109, 110, 118
103, 118
98
86
8
86, 101, 115
11, 43
120
82, 83, 97
94
91
121
93, 108, 123
86
46, 96
90, 92, 102
87
85, 119
103
119
106, 119
13, 86, 90
121
85
87
122
118
100, 114
93
107
83, 119
42
92
87, 93
90
29, 77
90
87, 120
88
107
101
92
112
81, 93, 94, 108, 110, 123
100
91
93
7
93
84
113, 117
106
98
95
115
84
114
91
59, 87, 100
AUTHOR INDEX
Chen, Chien-Hsiun
Chen, Jiayu
Chen, Qi
Chen, Sheng
Chen, Wei J.
Chibanda, Dixon
Chile, Thais
Chiliza, Bonginkosi
Chillotti, Caterina
Choi, Kwang H.
Choudhry, Zia
Chowdari, Kodavali
Chowdhury, Nabilah
Christian, Mehtab
Chung, Raymond
Chung, Wendy
Cichon, Sven
Cimarelli, Giulia
Claassen, Tom
Clapcote, Steven J.
Clarke, Toni
Cocchi, Enrico
Cohen, Bruce M.
Cohen, Dan
Cole, Christopher
Cole, James
Coleman, Jonathan
Collazo, Teresa
Collier, David
Collier, Sarah
Collinson, Simon
Colpe, Lisa
Colvert, Emma
Conde, Lucia Colodro
Congiu, Chiara
Congiu, Donatella
Conley, Emily Drabant
Conteras, Javier
Contini, Veronica
Conus, Philippe
Cools, Roshan
Coppola, Giovanni
Cordeiro, Quirino
Cormand, Bru
Corominas, Margarita
Corominas, Roser
Corrales, Montse
Corvin, Aiden
Cosemans, Nele
Cosgrove, Donna
Costas, Javier
Cost, Katherine T.
Couvy-Duchesne, Baptiste
Cox, Nancy
Coynel, David
Crane, Paul K.
Criquillion-Doublet, Sophie
Crisafulli, Concetta
106
106, 119
13, 14, 42, 98
88
106, 121
89
90, 96
119
90, 105
82
110
103
89
118
104
98
8, 92, 96, 100, 105, 111
86
109
92
111, 112, 114
118
100
105
84
96
83, 90, 100, 108
121
86, 91, 101, 104, 105, 108,
119
103
100
87
113
82, 102, 114
96, 106
90
87
97
81
84
110
104
121
81, 93, 94, 108, 110, 123
81
87
81, 94, 110
33, 120, 121, 122
88
122
120, 122
88
82, 87, 114
15, 35
102
85
116
85, 119
Crosbie, Jennifer
Crowley, James
Crow, Megan
Csorba, Jozsef
Cuellar-Partida, Gabriel
Cullen, Breda
Cummins, Tarrant
Cupertino, Renata B.
Curtis, Charles
Curtis, David
Czamara, Darina
Dahl, Hans A.
Daigre, Constanza
D’Aiuto, Leonardo
Daly, Mark
Danese, Andrea
Danesi, Michael
D’Angelo, Debra
Das, Dhanjit
da Silva, Bruna
Daskalakis, Zafiris
David, Anthony S.
Davies, Gail
Davis, Lea
Daya, Michelle
Day, Felix
Dazzan, Paola
Dean, Andy
Deary, Ian
Deckert, Jürgen
Degagne, Bryan
Degenhardt, Franziska
de Geus, Eco J.
Dekker, Rien
de Leeuw, Christiaan
DeLisi, Lynn
Delorme, Richard
De Luca, Vincenzo
Del Zompo, Maria
Demetrovics, Zsolt
Demirkan, Ayse
Demontis, Ditte
Dempster, David
Dempster, Emma
Deneault, Eric
Denny, Joshua
Densmore, Maria
de Oliveira, Camila M.
de Oliveira, Kátia
de Quervain, Dominique J.F.
Derks, Eske
Deshpande, Smita
Desmarais, Aline
de Vega, Wilfred
de Villena, Fernando
de Zubicaray, Greig
Dias, Brian
Díaz-Anzaldúa, Adriana
Page 127
81
91, 92, 103, 118, 122
13, 14, 79
123
114
85
109
81, 82
86, 118
90, 91
88
83, 90
108, 123
103
33, 98
82
117
98
103
82, 109
27, 62
90
60, 85
66
119
85
90
123
81, 85, 111, 112
97
98
83, 92, 93, 102, 105, 111,
116
86
91
79
7, 91
88
47, 61, 82, 86, 92
90, 105
123
97
42, 82, 90, 97
86, 118
78, 86, 101, 115
84
103
83
117
14, 88, 103
88, 102, 112, 114, 115
93
105, 106
87
86
92
87
116
95
AUTHOR INDEX
Díaz-Anzaldúa, Alejandro
Díaz-Madrid, Federico Alejandro
Diehl, Eric
Diez, Alvaro
Di Forti, Marta
Dima, Danai
Di Marchi, Samir
Dimatelis, Jacqueline
Dionne, Ginette
Direk, Nese
Dobmeier, Johanna
Docherty, Anna
Domenech, Laura
Domschke, Katharina
Donohoe, Gary
Dorph-Petersen, Karl-Anton
Dorr, Johannes
dos Santos, Ana Cecilia Feio
dos Santos, Ana Paula Martins
Draganski, Bogdan
Dragovic, Milan
Drineas, Petros
Drögemöller, Britt
Du, Yuhui
Duarte, Núbia E.
Duarte, Rodrigo Rafagnin
Ducci, Francesca
Dudbridge, Frank
Duffy, Walter
Duncan, Laramie
Dunn, Erin
Duong, Linh
Edenberg, Howard
Edwards, Alexis
Egli, Tobias
Eisen, Jonathan
Ekpor, Ibene
Elbert, Thomas
Elbi, Hayriye
Eley, Thalia
Elfving, Betina
Elia, Josephine
Elie, Dominique
Ellefsen, Gudrid Andorsdottir
Ellis, James
Emsley, Robin
Epelbaum, Jacques
Erdman, Lauren
Erhardt, Angelika
Erikson, Galina
Eriksson, Elias
Eriksson, Johan
Escamilla, Michael
Escaramís, Georgia
Escott-Price, Valentina
Eskin, Eleazar
Espinoza, Alfred
Esteba, Susanna
Estivill, Xavier
95
95
14, 61, 91
103
86, 90, 103
87, 102, 118
99
97
100, 114
97
115
91, 96, 103
87
59
120, 122
115
115
95, 98, 112
98
84
100
104
104, 119
119
117
120
108
34, 45
110
59, 118
59
88
67
46, 91, 96, 103
88, 114, 115
107
13, 96
111
92, 106
83, 100
82
81
105
90
84
104, 119
116
98
83, 97, 101
108
97
88, 116, 117
97
87
92, 113
107
112
88
87
Euesden, Jack
Evans, David
Evans, Jonathan
Everdeen, Tom
Fabbri, Chiara
Faghfoury, Hanna
Falkai, Peter
Fan, Chun Chieh
Fanous, Ayman
Faraone, Stephen
Farcia, Iris
Farfel, José Marcelo
Farkas, Kinga
Farmer, Anne
Farris, Sean
Farrow, Emily
Fastenrath, Matthias
Fauth-Bühler, Mira
Feliubadaló, Miriam Guitart
Fellendorf, Frederike
Felsky, Daniel
Feltrin, Arthur
Fernandez, Ana Maria
Fernandez, Thomas
Fernàndez-Castillo, Noèlia
Ferraboli, Sergio
Ferretti-Rebustini, Renata
Figueiredo, Anna Suarez
Filippich, Cheryl
Finos, Livio
Finucane, Hilary
Fiorentino, Alessia
Fischer, Sascha
Fisher, Simon E.
Fitzgerald, Jacqueline
Fitzsimmons, Chantel
Flatau, Laura
Fleming, Alison S.
Flint, Jonathan
Fonseka, Trehani
Forloni, Gianluigi
Fornito, Alex
Forstner, Andreas
Foster, Jane A.
Francis, Lily
Frangou, Sophia
Franke, Barbara
Frank, Josef
Freedman, David
Freeman, Natalie
Freimer, Nelson
French, Leon
Freytag, Virginie
Fromer, Menachem
Fry, Rebecca
Frye, Mark
Fu, Cindy
Fu, Wen-Mei
Fuchs, Robert
Page 128
45, 82, 84, 108, 118
98, 101
111
110
118, 119
117
120
85
91, 120
74, 81, 93, 102, 116
94
103
106
111
67, 93
104
102
102
122
82
70, 99, 104, 117
98
81, 111, 112
83
93, 108, 123
106
103
117
107
121
45
90
13, 96
88
88
90
13, 14, 57
88
96, 103
104
85, 119
102
43, 83, 96, 97, 111, 116
104
103
87, 102
7, 81, 95, 110, 118, 123
83, 92, 93, 105, 111, 116
83
89, 104, 116, 117
73
14, 99
88, 115
14, 71, 101, 106, 121, 122
95
111
96
121
82
AUTHOR INDEX
Fuentes, Carlos Cruz
Fuentes, Evelín
Fujii, Kumiko
Fullerton, Janice
Funakoshi, Shunichi
Gabriel, Oh
Gade, Katrin
Gadelha, Ary
Gage, Suzi
Gagliano, Sarah
Galan, Gina
Gale, Catharine
Gallagher, Louise
Gallego, Juan
Ganeshan, Sivasangary
Garcia-Martínez, Iris
García-Sánchez, Félix
Garza, Jacob
Gaughran, Fiona
Gaviria, Ana
Gawlik, Micha
Geaghan, Michael
Gecen, Ferya
Gejman, Pablo
Gelernter, Joel
Gennarelli, Masimo
Genovese, Giulio
George, Julie
Georgieva, Lyudmila
Gerlai, Robert
German, Bruce
Gershon, Elliott
Geschwind, Daniel
Ghosh, Ayantika
Giacopuzzi, Edoardo
Giaroli, Giovanni
Gibbons, Laura E.
Gibson, Jude
Gill, Michael
Gillespie, Amy
Gillis, Jesse
Giorda, Robert
Giusti-Rodriguez, Paola
Gizer, Ian
Gjeluci, Klaudio
Glatt, Stephen
Glennon, Jeffrey
Glerup, Simon
Glessner, Joseph
Goelman, Gadi
Goes, Fernando
Gofine, Timothy
Goldenberg, Anna
Gomez, Manuel
Gonçalves, Vanessa
Gonzalez, Lara Andrea Neira
Gonzalez, Suzanne
Gorwood, Philip
Gould, Ian
88
121
97
72, 102, 111
116
86
92, 120
95, 121
14, 92, 107
84, 86
121
85
88
119
89
81, 110
87
116
86, 90, 118
122
120
92
114
8
87
96, 106
78, 91
117
107
35
119
8
101
103
106
102, 114
85
111
8, 109, 122
86
99
104
92
61
116
74, 93, 98, 102, 105, 112
110, 118
82
81, 95
101
43, 83, 103
117
98
121
56, 119
85
97
116
90
Gountouna, Viktoria-Eleni
Gouvea, Eduardo
Gouveia, Gisele Rodrigues
Grabe, Hans-Jörgen
Graham, Kathryn
Grasman, Sara
Grassi-Oliveira, Rodrigo
Gratten, Jacob
Grau-López, Lara
Green, Melissa
Gregersen, Noomi
Grevet, Eugênio H.
Grinberg, Lea Tenenholz
Groenmann, Annabeth
Grouselle, Dominique
Grove, Jakob
Grzywacz, Anna
Gschwind, Leo
Gui, Jane
Guimarães-da-Silva, Paula O.
Gujral, Madusudan
Gunasinghe, Cerisse
Guo, Wenjun
Gurling, Hugh
Gurwitz, David
Gutiérrez-Mora, Doris
Hagenaars, Saskia
Hakonarson, Hakon
Haley, Chris S.
Haljas, Kadri
Hall, Jeremy
Hall, Lynsey
Hall, Mei-Hua
Halmi, Katherine A.
Halpern, Eric
Hambridge, Kirsty
Hammerschlag, Anke
Hammock, Bruce D.
Hamshere, Marian
Han, Buhm
Han, Changsu
Han, Jun
Han, Shizhong
Handsaker, Robert
Hanna, Gregory
Hannon, Eilis
Hansell, Narelle K.
Happé, Francesca
Haraksingh, Rajini
Hariri, Ahmad
Harripaul, Ricardo
Harrison, Rebecca
Harris, Sarah
Hartz, Sarah
Hasandedić, Lejla
Hashimoto, Ryota
Hathy, Edit
Hauberg, Mads Engel
Hawi, Ziarih
Page 129
85
121
88, 90, 96
100, 102
117
91
109
106, 107
108, 123
90
83, 97
81, 82
88
109
116
69, 90, 98
94, 108, 123
102, 114
91
81
84
86
98
115
119
95
85
81, 95, 99
81, 111, 112
88
88
111, 112
100
119
83
107
93
119
95
90, 122
82, 108, 118
92
67, 103
91
98
14, 60, 86, 101, 108, 115
114
113
113
87
96, 112
102, 113, 118
85
73, 93
83
7, 118
121
44
109, 110
AUTHOR INDEX
Hayden, Elizabeth
Hayward, Caroline
He, Enqi
He, Lin
He, Qin
Heath, Anna
Heck, Angela
Hedemand, Anne
Heeringa, Steven
Hegenscheid, Katrin
Heilbronner, Urs
Heilmann, Stefanie
Hellemann, Gerhard
Hemmings, Sian
Henning, Anke
Henriksson, Markus
Henry, Cameron
Herms, Stefan
Hernández-Lagunas, José
Heron, Jon
Herrera, Santiago
Herrmann, Nathan
Hertz-Picciotto, Irva
Heskes, Tom
Hess, Jonathan
Hettige, Nuwan
Hibar, Derrek
Hickie, Iam
Hill, Matthew
Hill, Rosamund
Hinsberger, Martina
Hippolyte, Loyse
Hoal, Eileen
Hochuli, David
Hoeffding, Louise
Hoexter, Marcelo
Hoffmann, Per
Hoffmann, Sabine
Hofmann, Andrea
Hollegaard, Mads
Holmans, Peter
Homann, Oliver
Homolya, László
Ho, New Fei
Hong, Qi-Sheng
Hoogman, Martine
Horimoto, Andréa R.V.R.
Horvath, Erzsebet Zsofia
Horvath, Steve
Hottenga, Jouke-Jan
Hougaard, David
Hovatta, Iiris
Howell, Kayla
Howrigan, Daniel
Hrabovsky, Anastasia
Hsiao, Po-Chang
Huang, Eric
Hubbard, Leon
Huckins, Laura
111
111, 112
91
7, 18, 39
118
102
88, 112, 115
83, 97
87
100
14, 82, 92, 105, 120
116
104
83, 97, 111
96
117
112
96, 100
95
95, 105
86
105
98
109
71, 93, 98, 102, 105
86, 92
70
87
101
112
111
84
119
114
113
88, 103
96, 100
93
92, 93, 105
115
44, 81, 106, 120
91
121
100
121
95
117
101
120
86, 96, 107
120
97
103
44, 78, 105
98
106
89, 104
105, 107
118
Hudson, Melissa
Hudson, Thomas
Hug, Matthias
Hwu, Hai-Gwo
Iakoucheva, Lilia
Ijzendoorn, Marinus Van
Ikeda, Masashi
Ikegame, Tempei
Inglehearn, Chris F.
Inglis, Angela
Iniesta, Raquel
Inkster, Becky
Ip, Hill Fung
Irwin, David
Ishigooka, Jun
Ishiwata, Mizuho
Ishizuka, Kanoko
Ising, Marcus
IskraTrifunović, Joanna
Islam, Md. Atiqul
Ismail, Khalida
Iurato, Stella
Ivorra, Jose
Iwamoto, Kazuya
Iwata, Nakao
Iyegbe, Conrad Osamede
Jablensky, Assen
Jabłoński, Marcin
Jacob-Filho, Wilson
Jacobs, Michelle
Jacobsen, Jessie
Jacquemont, Sébastien
Jahanabadi, Shahab
Jain, Sanjeev
Jain, Sonia
Jancic, Dubravka
Jansen, Rick
Jarvelin, Marjo-Riitta
Jasiewicz, Andrzej
Javitz, Harold
Jeffries, Aaron
Jenkins, Gregory
Jepsen, Jens Richard
Jin, Yu
Jockwitz, Christiane
Johansen, Oddbjørg
John, Jibin
John, Sujit
John, Ulrich
Johnson, Amelie Musa
Johnson, Colin
Johnson, Emma
Jöhren, Hans-Peter
Jones, Hannah
Jonge, Sylvia de
Jong, Simone de
Joo, Yeon Ho
Jospin, Guillaume
Juárez-García, Francisco
Page 130
112
16, 39
114
106, 121
112
103
86, 89, 104, 118, 120
86
92
87, 100
14, 80, 119
96
86
117
86
97
84, 122
101
108, 123
92
111
101
92
86
86, 89, 118
103
100
94
88, 103
94
112
84, 98
114
123
87
83, 103
96, 110
84
94, 108, 123
85
101, 115
111
107
119
100
83, 90
105, 106
122
102
118
92
105
83
92, 105
115
14, 83, 91, 105, 118, 121
110
107
95
AUTHOR INDEX
Julià, Antonio
Juraeva, Dilafruz
Kaas, Mathias
Kadarmideen, Haja
Kaerlev, Linda
Kahn, René S.
Kajantie, Eero
Kakiuchi, Chihiro
Kakuto, Yoshihisa
Kalman, Janos
Kalsi, Gursharan
Kaminsky, Zachary
Kaminsky, Zack
Kan, Carol
Kaneda, Ayako
Kane, John
Kang, Sim
Kang, Yuree
Kannaiyan, Nirmal Raman
Kantojärvi, Katri
Kao, Chally
Kapfhammer, Hans-Peter
Kaplan, David
Kappel, Djenifer
Karakiewicz, Beata
Karam, Rafael
Karbalai, Nazanin
Karchin, Rachel
Kasai, Kiyoto
Kasper, Siegfried
Kataoka, Muneko
Kato, Tadafumi
Kaufman, Joan
Kauwe, John S.
Kavanagh, David
Kawamura, Yoshiya
Kawase, Kohei
Kawashima, Ryuta
Kayahan, Bulent
Kaye, Walter
Kazuno, An-A
Kebir, Oussama
Keers, Robert
Keller, Matthew
Kelly, Benke
Kelly, Sinead
Kelsoe, John
Kendler, Kenneth
Kennedy, James L.
Kennedy, Sidney
Keohane, Aoife
Kepa, Agnieszka
Keskin, Duygu
Kessler, Ronald
Khandaker, Golam
Khan, Shabana
Khoza, Star
122
102
82
89
82
103, 107, 120
117
86, 110
116
105
108
89
60
111
117
119
100
110
120
69
99
82
34
81, 109
108, 123
81, 82
88
83, 103
86, 110
119
14, 97
8, 86, 97
74
85
106, 107
86, 110
89, 118
116
92, 106
85, 119
97
84
83
105
91
122
7, 8, 43, 68
46, 58, 93, 96, 103, 106,
120, 121
7, 8, 56, 82, 88, 89, 91, 97,
104, 116, 117, 119, 121
89, 104
104
113
92, 106
87
111
92
89
Kiefer, Falk
Kikuchi, Yoshie
Kim, Hyo-Won
Kim, Sanghyeon
Kim, Yunjung
Kimura, Hiroki
Kinnear, Craig
Kirli, Umut
Kirov, George
Kirschbaum, Clemens
Kish, Maxine
Klauser, Paul
Kleiber, Morgan
Kleindienst, Nikolaus
Klein, Izabella
Kleinman, Joel E.
Klein, Marieke
Klump, Kelly
Knight, Joanne
Knopik, Valerie
Knowles, James
Kodaka, Akira
Kogelman, Lisette
Kohler, Tobias
Kolassa, Iris
Komatsu, Hiroshi
Kondo, Kenji
Kong, Sekwon
Koofreh, Mary
Koren, Gideon
Kos, Mark
Kosmicki, Jack
Krämer, Laurenz
Kramer, Melissa
Krasnow, Ruth
Krause, Diane
Krebs, Marie-Odile
Krieger, José E.
Kristensen, Ann S.
Kruk, Emese
Kruse, Torben A.
Kubinyi, Eniko
Kukshal, Prachi
Kumarasinghe, Nishantha
Kumsta, Robert
Kuo, Po-Hsiu
Kushima, Itaru
Kweon, Kukju
Labrie, Viviane
Lachman, Herb
Lackner, Nina
Lafer, Beny
Lahey, Benjamin
Lahti, Jari
Lai, Chi-Yu
Lally, John
Lam, Max
Lamers, Femke
Landen, Mikael
Page 131
93, 102
116
110
99
92
84, 122
97
13, 92, 106
71, 107, 120, 122
83
89
102
111
116
106
82
95
85
7, 84, 86, 90, 113, 122
108
91
116
89
114
112
116
86, 89, 118
98
96
117
108
69
93
83, 103
85
87
84
117
83
101
83
86
13, 105, 106
105
101
106
84, 122
110
14, 60
98
82
88
103
88, 97, 116, 117
121
90
100
96
122
AUTHOR INDEX
Landi, Monica
Lang, Maren
Langenberg, Claudia
Langley, Kate
Lanius, Ruth
Laranjeira, Ronaldo
Larson, Eric B.
Laufer, Benjamin
Laughlin, Christopher
Laurent, Sandra
Lavebratt, Catharina
La Via, Luca
Lawrie, Stephen M.
Leach, Emma
Lebon, Sébastien
Lee, Byung Dae
Lee, Hsin-Yu
Lee, Jia-Ying
Lee, Jimmy
Lee, Jinkook
Lee, Phil
Lee, Sang Hong
Lee, Sang Hyuck
Lee, Soo-Jung
Lee, Su-Yin
Legge, Sophie
Lehner, Thomas
Lehnert, Klaus
Leite, Cláudia
Leménager, Tagrid
Lencze, Eric
Lencz, Todd
Lenroot, Rhoshel
Leonenko, Ganna
Leppä, Virpi
Lerch, Jason
Lerer, Bernard
Lescai, Francesco
Lester, Kathryn
Lett, Tristram
Leussis, Melanie
Levandowski, Mateus L.
Levinson, Douglas
Levy, Deborah
Lewis, Cathryn
Li, Jiang
Li, Shu
Li, Tao
Liappas, Ioannes
Lieberman, Jeffrey
Lien, Yin-Ju
Liewald, David
Lifschytz, Tzuri
Ligthart, Lannie
Lima, Leandro
Lima, Luzia Carreira
Limprasert, Pornprot
91
13, 83, 92, 93, 102, 105, 111,
120
85
95
83
86
85
91
104
118
97, 111
106
111
87
98
97
121
106
100
97
92, 103
106
83, 118
82, 108, 118
121
80
87
112
96
102
82
80, 119
102
106
116
34, 117
7, 101
90, 97
83, 100
13, 14, 78, 89
116
109
8, 46, 58, 110
100
7, 58, 82, 103, 105, 111, 113,
119
89
118
108
85
25, 53, 89, 91, 104
106
85
101
107
95, 98
103
112
Lindblad-Toh, Kerstin
Linding, Rune
Lind, Penelope
Lin, Guan Ning
Lin, Kuang
Lin, Mingyan
Lin, Yen-Feng
Lipska, Barbara K.
Lisboa, Bianca
Lisoway, Amanda
Liu, Chih-Min
Liu, Jiajia
Liu, Jingyu
Liu, Xiehe
Liu, Xudong
Liuhanen, Johanna
Llanes, Yasmany
Loa, Peter
Lobo, Daniela
Lochner, Christine
Logan, Clare
London, Edythe
Loohuis, Loes Olde
Looper, Karl
Lopez-Morinigo, Javier
Lotan, Amit
Love, Seth
Lowry, Jennifer
Lucae, Susanne
Lunnon, Katie
Lysenko, Laura
Ma, Lisha
Ma, Xiaohong
Maaser, Anna
Macé, Aurélien
Machado-Vieira, Rodrigo
MacIntyre, Donald J.
Maciukiewicz, Malgorzata
Maddox, Stephanie
Madsen, Majbritt Busk
Maes, Hermine
Maffioletti, Elisabetta
Magistretti, Pierre
Magnusson, Patrik
Magri, Chiara
Maher, Brion
Mahmood, Tariq
Maier, Robert
Maier, Wolfgang
Maillard, Anne
Maillard, M.
Maina, Giuseppe
Maj, Carlo
Mak, Denise
Małecka, Iwona
Malhotra, Anil
Malik, Rainer
Malki, Karim
Maller, Julian
Page 132
103
96
82, 102
112
103
98
100
82
88, 98, 103, 112
89, 104
106, 121
111
106, 119
108
112
116
121
107
7, 47
83, 97
92
123
107, 120
105
90
101
99
104
101
115
101
116
108
96
84
96
112
70, 89, 104, 121
116
89
93
13, 96
119
85
106
91
92
13, 14, 45, 79, 120
96
98
84
96
96
86
94, 108, 123
7, 119
88
102
98
AUTHOR INDEX
Malzahn, Dörthe
Mandelli, Laura
Mangezi, Walter
Mangul, Serghei
Mann, Karl F.
Mannik, Katrin
Manser, Paul
Mantripragada, Kiran
Marcheco, Beatriz
Marees, Andries
Margraf, Jürgen
Mari, Jair
Marie, Suely Kazue Nagahashi
Marín, Lilia C.
Marino, Cecilia
Marioni, Riccardo
Maron, Eduard
Marsal, Sara
Marshe, Victoria
Martin-Brevet, Sandra
Martines, Rosalba
Martinez, Daniela
Martínez-Luna, Nieves
Martin, Jessica
Martin, Joanna
Martin, Nick
Martorell, Lourdes
Maruya, Pawan
Marzi, Sarah
Masand, Prakash S.
Mascherettim, Sara
Maschietto, Mariana
Massand, Prakash S.
Masuka, Josiah
Mathe, Aleksander
Mathews, Carol
Matoba, Nana
Matsuo, Koji
Mattheisen, Manuel
Matthews, Paul
Maughan, Barbara
Mayfield, R. Dayne
Mazin, Wiktor
McCabe, James
McCarroll, Steven
McCarthy, Nina
McCombie, William
McCoy, Sarah
McCracken, James
McDonald, Colm
McDonough, Stefan
McElroy, Susan
McGeary, John
McGhee, Kevin
McGough, James
McGowan, Patrick
McGrath, John
McGregor, Nathaniel
McGuffin, Peter
105
82
89
107
93, 102
84
86
107
121
93
83
121
98
121
100, 104, 114
85
97
122
89, 104, 105
84, 98
85, 119
90
108
111
81, 95, 107
7, 87, 91, 114
122
109
101
118
104
86
82
13, 89
111
104, 118
97
97
7, 82, 120
96
82
67, 93
84, 113
105
91, 113
14, 100
83, 103
112
104
122
91
111
108
100, 113, 116
104
86
106
83, 97, 104
96, 111
McInnis, Melvin
McIntosh, Andrew
McLean, Duncan
McMahon, Francis
McMahon, Katie
McQuillin, Andrew
Meaburn, Emma
Meaney, Michael
Mechawar, Naguib
Medeiros, Helena
Medland, Sarah
Mehta, Divya
Mei, Hailiang
Meier, Sandra
Meijsen, Joeri
Mekli, Krisztina
Mekonnen, Zeleke
Melis, Carla
Melka, Melkaye
Melton, Phillip
Meltzer, Herbert
Memic, Amra
Mendlewicz, Julien
Mentch, Frank
Mercer, Kristina
Mernick, Ben
Metrik, Jane
Meyer, Christian
Micali, Nadia
Michaelson, Jacob
Michelon, Leandro
Mick, Eric
Middeldorp, Christel M.
Miguel, Euripedes
Mihaljevic, Marina
Mike, Árpád
Mikhailov, Anna
Milaneschi, Yuri
Milian, Danys de las Nieves
Mill, Jonathan
Miller, Neil
Miller, Steven M.
Mill, Jonathan
Mills, Melinda
Milnik, Annette
Minelli, Alessandra
Mirjanic, Tijana
Miskowiak, Kamilla
Misura, Kira
Mitchell, Colter
Mitchell, Philip
Mittal, Kirti
Miyagawa, Taku
Moebus, Susanne
Moghimi, Narges
Mokrab, Younes
Molero, Patricio
Page 133
43, 72
72, 81, 85, 103, 111, 112,
114
107
8, 24, 48, 57, 68, 82
87
90, 102, 103, 114, 115
113
88
108
91
10, 54, 81, 82, 102, 114
106
96
58, 59, 82, 120
85
97
93
90
91
100
89, 104
83
119
99
116
101
108
102
118
89
90
81
107
83, 88, 103, 119
13, 107
121
112
96
121
86, 93, 95, 101, 108, 113,
115
104
114
60
106
88, 102, 115
96
107
96
91
87
8, 72, 73, 111
98, 112
110
100
96
91
104
AUTHOR INDEX
Moll, Kristina
Molteni, Massimo
Monaco, Anthony P.
Mondelli, Valeria
Monson, Eric
Montgomery, Grant
Montgomery, Stephen
Montgomery, Stuart
Monzon, Giessel
Mora, Cristina Sanchez
Morales, Enny
Moran, Jennifer
Morar, Bharti
Moreno, Ricardo
Moretti, Patricia
Moretto, Ariane Cristine
Morgan, Joanne
Morgan, Vera
Morgello, Susan
Mori, Daisuke
Morisseau, Christopher
Morris, Andrew P.
Morris, Derek
Morris, Emily
Morris, Sarah
Mors, Ole
Mortensen, Preben Bo
Moses, Eric
Mostacciuolo, Maria Luisa
Mostafavi, Sara
Mota, Nina R.
Mottron, Laurent
Mowry, Bryan
Müehleisen, Thomas
Müeller, Daniel
Muglia, Pierandrea
Mühleisen, Thomas
Mukherjee, Shubhabrata
Müller-Myhsok, Bertram
Müller, Nikola
Mullins, Niamh
Mulsant, Benoit
Munafo, Marcus
Munk, Thomas
Munn-Chernoff, Melissa
Murabito, Joanne
Murphy, Jillian
Murphy, Therese
Murray, Robin
Murthy, Prathima
Muser, Inga
Musil, Richard
Musser, Erica
Naaien, Jilly
Nagami, Fuji
Nakamura, Kazuhiko
Nakamura, Yukako
Nam, Hyun-Jun
88
100, 114
88
90
13, 14, 59, 103
82, 102
110
119
121
93, 94
121
91, 113
100
96
121
88
107
100
94
84, 122
119
88
122
87
74
7, 82, 83, 90, 97, 107, 115,
120, 121
82, 98, 117, 120
100
121
110
81, 82, 109
84
106, 107, 122
100, 116
7, 89, 91, 104, 105, 116
96
96
85
88, 97
84
43, 66
82
92, 100, 107
82
118
97
117
14, 60, 115
78, 86, 90, 103, 118, 120
123
89
115
95
110
57
117
84, 122
112
Nanjiani, Zohair
Nassan, Malik
Nathan, Ryan
Navarro, Pau
Nazeri, Arash
Nazroo, James
NcNaughton, Amy
Neale, Benjamin
Negrão, André B.
Neijt, Joep
Nelson, Paul
Nemesh, J.
Nemoda, Zsofia
Nertney, Deborah
Neumann, Alexander
Neves, Ricardo de Caires
Newhouse, Stephen
Ngo, Trung
Nhachi, Charles
Nichols, Tom
Nicodemus, Kristin
Nicolini, Humberto
Niehaus, Dana
Nielsen, Anders
Nielsen, Marit
Nigg, Joel
Nimgaonkar, Vishwajit
Niola, Paola
Nishimura, Fumichika
Nivard, Michel
Nobrega, Jose
Nock, Matthew
Noens, Ilse
Nolan, Matthew
Nonneman, Randy
Nordentoft, Merete
Nöthen, Markus
Noto, Cristiano
Novakovic, Ivana
Novell, Ramon
Nudelman, German
Nurmi, Erika
Nurnberger, John
Nyegaard, Mette
Nyengaard, Jens
Nyholt, Dale
Obel, Carsten
O’Brien, Niamh
Ocampo-Mendoza, Yolanda
O’Connell, Kevin
O’Donovan, Michael
O’Dushlaine, Colm
Oh, Dong Hoon
Ohadi, Mina
Okada, Takashi
Okahisa, Yuko
Olivares, Begona
Page 134
118
111
110
112
70, 99, 117
97
112
7, 79, 81, 87, 106
86, 117
114
91
91
83, 101
107
103
88
108
114
89
96
74, 85, 96, 114
21, 39, 41, 97
119
115
83, 115
95
44, 103, 105, 106
90, 105
86
86, 107
47
87
88
120
92, 122
107, 120
8, 83, 88, 92, 93, 96, 100,
102, 105, 111, 116
121
107
88
94
104, 123
7, 8, 72
90, 115
115
82, 102
115
13, 14, 43, 90
95
104
7, 12, 44, 92, 95, 105, 106,
107, 113, 115, 120, 122
91
99
96
84
107
94
AUTHOR INDEX
Olsen, Jørn
Olsen, Line
Onay, Huseyin
Ongur, Dost
Ono, Takashi
Ophoff, Roel
O’Reilly, Paul
O’Reilly, Richard
Ori, Anil
Orizio, Flavia
Ortega-Ortiz, Hiram
Oruc, Ljiljana
Os, Jim Van
Ossowski, Stephan
Østergaard, Søren D.
Ota, Vanessa
Otaduy, Maria Concepcion
Otowa, Takeshi
Ovenden, Ellen
Owen, Michael
115
113
92, 106
34, 56, 100
116
105, 107, 120
45, 84, 99, 102, 113
91
107, 120
106
95
83
92, 106, 120
87
13, 85
121
96
110
13, 104
9, 55, 81, 92, 105, 106, 107,
113, 120, 122
Oya, Yuko
122
Oya-Ito, Tomoko
84
Ozaki, Norio
84, 122
Ozkinay, Ferda
92, 106
Padmanabhan, Sandosh
112
Pae, Chi-Un
82, 108, 118
Pagerols, Mireia
81, 94, 110
Pain, Aurélie
84
Painter, Jodie
82, 102
Palmer, Rohan
108
Palotie, Aarno
116
Pandey, Subhash
67
Pang, Ken
110
Pantellis, Christos
102
Papadimitriou, George N.
85
Papassotiropoulos, Andreas
88, 102, 112, 114, 115
Papiol, Sergi
93, 105, 120
Paracchini, Silvia
88
Páramo, Mario
120
Pardiñas, Antonio
120
Pariante, Carmine
90
Parikshak, Neel
101
Park, Min Tae M.
113
Parla, Jennifer
83, 103
Parsian, Abbas
67
Parvathaiah, Harish Ganipaneni 14, 120
Paschou, Peristera
104
Pasqualucci, Carlos Augusto
88
Pastorello, Bruno
96
Patel, Sejal
113
Paternoster, Lavinia
102, 111
Patkar, Ashwin A.
82, 108, 118
Pato, Carlos
91
Pato, Michele
91
Paull, Gregory
93
Pauls, David
103, 118
Paunio, Tiina
116
Paus, Tomáš
34, 99
Paz, Eduardo
Pedersen, Carsten B.
Pedrini, Mariana
Pedrosa, Erika
Peeters, Hilde
Pell, Jill
Pellegrino, Renata
Peñas, Javier
Pendleton, Neil
Penninx, Brenda
Percy, Alan
Pereira, Alexandre C.
Pereira, Carlos Alberto
Pérez-García, Débora
Pérez-Jurado, Luis A.
Pérez-Pazos, Jesús
Periyasamy, Sathish
Perrone-Bizzozero, Nora
Pervolaraki, Eleftheria
Pesti, Krisztina
Petek, Erwin
Petersen, Claus
Petersen, Liselotte
Peterson, Roseann
Petronis, Art
Petryshen, Tracey
Peyrot, Wouter J.
Phillips, Drystan
Phillips, Katharine
Piazza, Caterina
Pidsley, Ruth
Pietilainen, Olli
Piptione, Jon
Pira, Shamira
Pirooznia, Mehdi
Pisanu, Claudia
Plamondon, André
Platzer, Martina
Plomin, Robert
Pocklington, Andrew
Poelmans, Geert
Polgár, Patrícia
Polina, Evelise R.
Politis, Antonios
Pomarol-Clotet, Edith
Porcelli, Stefano
Porjesz, Bernice
Porteous, David
Porter, Heather
Portolese, Joana
Posthuma, Danielle
Potash, James
Potkin, Steven
Pouget, Jennie
Powell, John F.
Powell, Timothy
Prat, Gemma
Prescott, Carol
Prieto, Miguel
Page 135
120
113, 117, 120
121
98
88
85
95
120
97
96, 110, 113
117
117
88, 103
87
87
93
107, 122
106, 119
92
121
82
82
82
13, 46, 96, 103, 120
7, 26, 55, 86
85, 116
113
97
119
100, 114
108, 115
116
84
105
83, 103
90, 105
88
82
113
92, 113
118
106
81
85
122
85, 104, 108
108
81, 85, 111, 112
99
98
33, 70, 93
8, 83, 103, 110
89, 91, 104
14, 44, 90, 122
85, 103
104
93, 108
97
7
AUTHOR INDEX
Proitsi, Petroula
Ptak, Carolyn
Puga, Renato
Pulay, Attila
Purcell, Shaun
Purmann, Carolin
Purushottam, Meera
Qayyum, Arqam
Qin, Li
Qing, Ying
Quackenbush, Corey
Quee, Piotr J.
Quehenberger, Oswald
Rabionet, Raquel
Räikkönen, Katri
Rajamani, Mahesh
Ramirez, Mercedes
Rammos, Alexandros
Ramos-Quiroga, Josep Antoni
Ramoz, Nicolas
Rampino, Antonio
Ramus, Franck
Ranlund, Siri
Rantalainen, Ville
Rapoport, Judith
Rasmussen, Henrik Berg
Rautiainen, Marja-Riitta
Raventós, Henriette
Raychaudhuri, Soumya
Real, Eva
Rees, Elliott
Rehm, Jurgen
Reimers, Mark
Reininghaus, Eva
Reis, Viviane
Rej, Soham
Rentería, Miguel E.
Repo-Tiihonen, Eila
Ressler, Kerry
Réthelyi, János
Reymond, Alexandre
Reynolds, Charles F.
Ribasés, Marta
Ribeiro, Gustavo
Ribeiro, Marcelo
Rice, John
Richards, Alexander
Richarte, Vanessa
Richter, Peggy
Rietschel, Liz
Rietschel, Marcella
Riley, Brien
Ring, Susan
Ripke, Stephan
Riva, Valentina
Rivera, Margarita
Rizzo, Lucas B.
Roach, Jared
85
86
103
106
7
60
123
97
116
13, 120
92
92
119
87
88, 97, 117
110
97
85
81, 94, 108, 110
116
114
84, 88
103
117
99
89
116
97
90, 122
87
107, 120, 122
117
86
82
95, 98, 112
105
114
116
73, 116
106, 121
84, 98
82
81, 93, 94, 108, 110, 123
103
86
8
78, 106, 120
81, 94, 110
7, 59, 119
83
7, 8, 43, 57, 83, 92, 93, 96,
102, 105, 111, 116, 120
121
98
12, 33, 78, 87, 120
100, 114
111
109
97
Robaina, Zoe
13, 121
Roberts, Susanna
83
Robinson, Delbert
119
Robinson, Elise
69, 98
Rodrigues, Luciana Tovo
82
Rodriguez-Cintas, Laia
93
Rodríguez-Granado, Miguel Ángel 87
Rodriguez-Herreros, Borja
84
Rodriquez, Marco
97
Roepke, Stefan
116
Rohde, Luis
81, 82, 95
Rohrbacher, Anna
92
Romo-Nava, Francisco
95
Ronai, Zsolt
86
Ronald, Angelica
98, 113
Roncero, Carlos
93, 108, 123
Ronchi, Diana De
85, 108
Roostaei, Tina
99
Ros-Cucurull, Elena
108, 123
Rosengren, Anders
117
Rossner, Moritz J.
120
Rotenberg, David
84
Rotzinger, Susan
89, 104
Rouillon, Frédéric
116
Roussos, Panos
101
Rovaris, Diego
13, 81, 82, 109
Rovira, Eulalia
87
Rubiś, Błażej
94
Rück, Christian
97
Ruderfer, Douglas
71, 80, 122
Rujescu, Dan
7, 8, 80, 103, 116
Rumpf, Hans-Jürgen
102
Russell, Evan
117
Russell, Vivienne
97
Rutten, Bart
120
Rutter, Michael
101
Ryan, Allison
92
Ryu, Euijung
111
Sacchetti, Emilio
106
Sadahiro, Ryoichi
115
Sadee, Wolfgang
17, 41
Saemann, Philipp
96
Saida, Harumi
86
Saigi-Morgui, Nuria
14
Saito, Takeo
89, 118
Sakamoto, Kensuke
91
Sakamoto, Shinji
107
Salfi, Raffaele
85
Salgado, Carlos A. I.
81
Sallis, Hannah
111
Salvoro, Cecilia
121
Samochowiec, Jerzy
94, 108, 123
Samudio, Ana Julia Aguirre
88
Sánchez-Mora, Cristina
81, 110, 123
Sanjuan, Julio
122
Santavy, Larysa
112
Santomé, Luis
120
Santoro, Marcos
121
Santos, Bruna
81
Page 136
AUTHOR INDEX
Santos, Eduarda
Sarkadi, Balázs
Sarkozy, Peter
Saruwatari, Junji
Sasaki, Tsukasa
Sasvari-Szekely, Maria
Sato, Flavia
Saunders, Carol
Sawa, Akira
Sawada, Tomoyo
Scerri, Thomas S.
Schachar, Russell
Schalkwyk, Leo
Schalling, Martin
Scharf, Jeremiah
Schennach, Rebecca
Scherer, Stephen
Schläppi, Sulamith
Schmahl, Christian
Schnalzenberger, Mario
Schneider, Silvia
Schoenbaum, Michael
Schoenmaker, Gido
Schofield, Peter
Schoof, Erwin
Schork, Andrew
Schork, Nicholas
Schott, Bjoern
Schuch, Jaqueline B.
Schulte-Körne, Gerd
Schulze, Thomas
Schumacher, Johannes
Scott, Laura
Scott, Robert A.
Scott, Rodney
Seaman, Lauren
Sebat, Jonathan
Seedat, Soraya
Sekar, Aswin
Semaka, Alicia
Serretti, Alessandro
Severino, Giovanni
Shaikh, Sajid
Sham, Pak
Shamsi, Mehrdad
Shankarappa, Bhagyalakshmi
Sharp, Sally
Sharp, Stephen J.
Shavitt, Roseli
Shaw, Alex D.
Sheikh, Haroon
Sheikh, Taimoor
Shen, Sanbing
Shi, Jianxin
Shieu, Mu-Jung
Shih, Pei-an Betty
Shiino, Yomoko
Shimada-Sugimoto, Mihoko
93
121
123
117
86, 110
86, 123
98
104
7
97
88
81
86, 101, 108, 113, 115
7, 90
104, 118
115
81, 84
114
116
82
83
87
109
7, 102, 111
96
85
119
116
81, 82
88
7, 8, 22, 39, 57, 82, 92, 93,
96, 105, 111, 120
88, 97
68
85
90, 102
13, 104, 123
8, 84
111
44
99
82, 85, 108, 118, 119
90, 105
91, 117
7
86
13, 123
90
85
88, 103, 119
102, 111
83, 100, 111
98, 117
88
110
121
119
122
110
Shimasaki, Ayu
Shin, Eun-soon
Shinkai, Takahiro
Shumskaya, Elena
Sibony, David
Siddiqui, Waquar
Sieberts, Solveig
Silva, Alex Perreira
Silva, Katiane L.
Silva, Patricia
Silver, Josh
Simmons, Andy
Simões, Sérgio
Sinclair, Lindsey
Singh, Shiva
Singh, Tarjinder
Sklar, Pamela
Skuse, David
Sleiman, Patrick M.A.
Smart, Neil
Smeester, Lisa
Smit, August
Smit, Johannes
Smith, Adam
Smith, Blair H.
Smith, Daniel
Smith, George Davey
Smith, Heather
Smith, Laurie
Smoller, Jordan
Snell, Russell
Snieder, Harold
Snyder, LeeAnne
So, Joyce
Sobell, Janet
Sobrino, Beatriz
Sobrino, Blanca Zoila González
Socrates, Adam
Soda, Takahiro
Soden, Sarah
Soeiro-de-Souza, Márcio
Sokolova, Elena
Sokolowski, Marla
Sommer, Jessica
Sonderby, Ida
Sonuga-Barke, Edmund
Soriano, Jordi
Souery, Daniel
Spalek, Klara
Spanagel, Rainer
Sparsø, Thomas
Spiegelman, Dan
Spiers, Helen
Spindola, Leticia
Spiro, John
Squassina, Alessio
Sriretnakumar, Venuja
Srivastava, Deepak P.
St Porcain, Beate
Page 137
89, 118
110
99
95
117
110
101
82
81
121
117
96
98
99
91, 100, 111
14, 60
33, 68
98
95
115
95
91
110
115
112
85
95, 98, 105, 107, 111
107
104
7, 8, 71, 87
112
88
98
117, 121
91
120
88
84
103
104
96
109
34
111
70
101
123
119
112
93
84
118
14, 101, 108, 115
121
98
90, 105
121
120
42, 95, 98, 107
AUTHOR INDEX
Stahl, Eli
Stamova, Boryana
Starnawska, Anna
Staunstrup, Nicklas
Stavropoulos, James
Stein, Dan
Stein, Murray
Steiner, Meir
Stergiakouli, Evie
Stevens, Adam
Stingl, Julia
Strauss, John
Streit, Fabian
Strike, Lachlan
Strohmaier, Jana
Strydom, Andre
Stueber, Kerstin
Suchanecka, Aleksandra
Sugawara, Hiroko
Sui, Jing
Sul, Jae Hoon
Sullivan, Patrick
Sun, Wei
Susser, Ezra
Sutcliffe, Jim
Swan, Brendan
Szalóki, Szilvia
Szatkiewicz, Jin
Szilagyi, Agnes
Sznabowicz, Mariusz
Szőcs, Katalin
Tabet, Anne-Claude
Tahira, Ana
Takahashi, Yukitoshi
Takaki, Manabu
Takasaki, Yuto
Takata, Atsushi
Takeuchi, Hikaru
Taki, Yasuyuki
Talarico, Fernanda
Tampakeras, Maria
Tanii, Hisashi
Tansey, Katherine
Tansley, Rosa Spencer
Taporoski, Tâmara
Tatarsky, Pavel
Taylor, Amy
Taylor, Juliet
Teismann, Tobias
Teo, Yik Yeng
Tesfaye, Markos
Tessema, Fasil
Teumer, Alexander
Thakur, Aditi
Thapar, Anita
Thara, Rangaswamy
Thelma, BK
Thiffault, Isabelle
68, 101
98
115
115
112
83, 97
87
88
14, 42, 95, 105, 107
97
119
7
83, 93, 96, 102, 111
87
83, 92, 93, 96, 105, 111
102, 114
114
94
86
119
104
8, 33, 58, 66, 85, 91, 92,
103, 106, 110, 118, 121, 122
92, 99
93
69
112
121
85, 99, 118, 122
123
108, 123
106
88
95, 98, 103, 112
118
107
84, 122
97
116
116
121
117
118
105, 120
57, 113
117
101
92
112
83
100
93
93
100
111
42, 81, 95, 107
122
7, 19, 39, 40, 105, 106
104
Thomas, Michael
Thompson, Paul
Thompson, Tadeo
Thomson, Pippa
Thorgeirsson, Thorgeir
Thornton, Laura
Thorup, Anne
Thygesen, Johan Hilge
Tian, Lifeng
Tiemeier, Henning
Tienari, Pentti
Tiihonen, Jari
Tilling, Kate
Timmerman, Harro
Timpson, Nicholas
Tischfield, Jay
Tiwari, Arun
Tokunaga, Katsushi
Toma, Claudio
Tomblin, Bruce
Tomita, Hiroaki
Tong, Janette
Tooney, Paul
Tosato, Sarah
Trabjerg, Betina B.
Tractenberg, Saulo G.
Treutlein, Jens
Trezzi, Vittoria
Troakes, Claire
Tropea, Daniela
Tropf, Felix
Tropper, Bernhard
Trujillano, Daniel
Tsetsos, Fotis
Tsuchimine, Shoko
Turecki, Gustavo
Turner, Jessica
Tylee, Daniel
Tzeng, Jung-Ying
Uddin, Mohammed
Udofia, Owoidoho
Uher, Rudolf
Umekage, Tadashi
Uno, Yota
Unternaehrer, Eva
Urban, Alexander
Urresti, Jorge
Ursano, Robert
Ussel, Maria D. Iglesias de
Uum, Stan van
Valenti, Jaime
Vallada, Homero
Valle, Giorgio
van Beijsterveldt, Toos
Van Den Bree, Marianne
van den Brink, Wim
van den Heuvel, Edwin R.
van der Auwera, Sandra
van der Merwe, Lize
Page 138
87
87
84
71, 112
7
85, 118
107
103, 117
95
97, 103
117
116
107
110
95, 98
87
80, 89, 104
110
111
89
116
14, 109, 110
90, 105
120
113
109
92, 93, 105, 111, 116
104
101, 108, 115, 120
120
106
82
87
13, 104
117
108, 115
106, 119
93, 98, 105, 112
85
34
96
72
110
84
88
110, 113
112
87
92
117
121
7, 20, 39, 40, 86, 90, 96, 117
121
107
88, 98
93
92
100
104, 119
AUTHOR INDEX
van de Vondervoort, Ilse
van Donkelaar, Marjolein M.J.
van Duijn, Cornelia
Vangkilde, Anders
van Grootheest, Gerard
van Hijum, Sacha
Vanni, Roberta
van Rens, Anne
Van Zeeland, Ashley
Vasli, Nasim
Vasquez, Alejandro Arias
Vassos, Evangelos
Vawter, Marquis
Vazza, Giovanni
Ventura, Rafael
Verbelen, Moira
Vereczkei, Andrea
Verhage, Matthijs
Verhulst, Frank
Verleyen, Wim
Vernon, Suzanne
Verrelli, Brian
Versini, Audrey
Verweij, Karin J.H.
Viana, Joana
Vidal, Raquel
Vidler, Lewis
Vieira, Henrique C.
Vieland, Veronica
Viladevall, Laia
Vilella, Elisabet
Villa, Erika
Vinberg, Maj
Vincent, John
Vinkhuyzen, Anna
Viranyi, Zsofia
Virkkunen, Matti
Visscher, Peter
Viswanath, Biju
Vitola, Eduardo S.
Vitor, Marcelo
Vivian-Griffiths, Timothy
Viviano, Joseph
Vőfély, Gergő
Vogler, Christian
Voineskos, Aristotle
Voltes, Núria
von Plessen, Kerstin
Von Schantz, Malcolm
Vorstman, Jacob
Vukojevic, Vanja
Waha, Andreas
Waha, Anke
Wallace, Douglas
Walters, James
Walters, Raymond
Walter, Stefan
Walton, Jordon
Wan, Chunling
118
123
97
113
96, 110
110
90
95
119
112
81
71, 90
56
121
121
105, 119
13, 123
91
103
79
86
121
116
86
93, 101, 108, 115
110
91
86
87
110
122
97
115
7, 69, 96, 98, 112, 117
122
86
116
106
123
82
81
113
117
121
88, 102, 114, 115
7, 70, 99, 117
108
107
117
44
112, 115
82
82
28, 65
105, 106, 113, 120
33, 79, 81
85
116
120
Wang, August G.
Wang, Chenyao
Wang, Hong
Wang, Jun
Wang, Ping
Wang, Shi-Heng
Wang, Wei
Wang, Weibo
Wang, Yingcheng
Wannemüller, Andre
Wareham, Nicholas J.
Ware, Jennifer
Waris, Mohammed
Warnich, Louise
Weale, Michael
Webb, Bradley
Wegener, Gregers
Wei, Yabin
Weickert, Cynthia Shannon
Weierstall, Roland
Weinsheimer, Shantel
Weissman, Myrna
Welham, Christine
Wells, Samantha
Werge, Thomas
Whalley, Heather
Wheeler, Anne
White, Hannah
Whitford, Tom
Widomska, Joanna
Wigmore, Eleanor
Wilcox, James
Wildman, Nick
Wilker, Sarah
Wilkinson, Iain D.
Willemsen, Gonneke
Williams, Nigel
Williams, Stephanie
Willour, Virginia
Wilmot, Beth
Windpassinger, Christian
Wineinger, Nathan E.
Winterhalter, Annika
Wittfeld, Katharina
Witt, Stephanie
Woldbye, David P.D.
Wolf, Christiane
Wolf, Gilly
Wolfe, Kate
Wong, Albert
Wong, Anson
Wong, Chloe Chung Yi
Wood, Joel
Woodruff, Peter
Woodside, Blake
Wray, Naomi
Wright, Galen
Page 139
83, 90, 97
13, 84, 122
104
90
98
106
99
99
108
83
85
61
110
104, 119
119
46, 96, 121
111
14, 111
102
111
84
110
104
117
84, 88, 113, 117, 120
111
117
87
102
118
111, 114
122
93
112
92
86, 96
81
122
83, 103
95
112
108
114
100
83, 92, 93, 102, 105, 111,
116
83, 97
97
101
102, 114
34
90, 122
101, 113
103
92
119
45, 66, 106, 109, 113, 120,
122
119
AUTHOR INDEX
Wright, Margie
Wu, Jer-Yuarn
Wu, Timothy
Xavier, Gabriela
Xia, Baocong
Xing, Jingrui
Xiong, Hui Yuan
Xiong, Lan
Xu, Qingqing
Xulu, Khethelo
Yamada, Norihito
Yang, Jian
Yang, Jun
Yao, Yin
Yasui-Furukori, Norio
Yildirim, Kubra
Yilmaz, Zeynep
Yolken, Robert
Yoneda, Hiroshi
Yoshikawa, Akane
Yoshimi, Akira
Yu, Dongmei
Yu, Sung-Liang
Yu, Ya-Hui
Yue, Weihua
Yuen, Ryan
Zachi, Elaine
Zagli, Nesli
82, 87, 102, 114
106
120
121
113
84, 122
34
118
102, 113
13, 111
107
106
119
83
117
92, 106
118
107
7
86
84, 122
104
121
121
107
14, 69
98
92, 106
Zai, Clement
Zai, Gwyneth
Zalesky, Andrew
Zammit, Stanley
Zandi, Peter
Zaslavsky, Kirill
Zavala, Juan
Zeeb, Fiona
Zeggini, Eleftheria
Zelaya, Ivette
Zeng, Yan-ni
Zerwas, Stephanie
Zhang, Dai
Zhang, Jianping
Zhang, Zheng
Zhang-James, Yanli
Zhao, Jingjing
Zhao, Qiongyi
Zheng, Deyou
Zhu, Lingxue
Zhu, Xiaowei
Zilhao, Nuno
Zilles, Karl
Zill, Peter
Zohar, Joseph
Zwiers, Marcel
Page 140
88, 89, 91, 97, 104, 117, 119,
121
96, 119
102
92, 95, 105, 107
68, 83, 103
84
97
47
118
104
112
118
107
119
98
74, 102, 116
13, 14, 122
109
98
66
110
113
100
115
119
110
See you next year at the
XXIVth World Congress
of Psychiatric Genetics
Oct. 30-Nov. 4, 2016
Jerusalem, Israel

Oral/Poster Finalist - WCPG 2015

Transcription

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