Fluoride PROFESSIONAL FLUORIDE APPLICATIONS IN THE DENTAL SURGERY Fluoride varnish

Transcription

Fluoride PROFESSIONAL FLUORIDE APPLICATIONS IN THE DENTAL SURGERY Fluoride varnish
Fluoride
Practice Information Sheet No. 2
Professional
Table 2:
Emergency action for fluoride overdose
Amount F ingested
Recommendation
< 5 mg/kg body weight
1.Give calcium orally (milk). Observe for few hours
> 5 mg/kg body weight
1.Give oral calcium
2.Admit to hospital and observe for few hours
Summary
Professional applications of fluorides play an important and
valuable role in the prevention and management of dental
caries in moderate- and high-risk patients, but use should be
restricted to those categories of patient.
The following are specific numbered recommendations from
guidelines for fluoride use in Australia (ARCPOH 2006):
(15) Fluoride varnish should be used for people who have
elevated risk of developing caries, including children under the
age of 10 years, in situations where other professionally applied
fluoride vehicles may be unavailable or impractical.
(16) High concentration fluoride gels and foams (those
containing more than 1.5 mg/g fluoride ion) may be used for
people aged 10 years or more who are at an elevated risk of
developing caries in situations where other fluoride vehicles
may be unavailable or impractical.
A summary of recommendations for professional fluoride
application is provided in Table 3.
Table 3:
Summary of recommendations for
professional fluoride application
12 months to
<10 years
10 to 18
years
18+
years
Low risk
–
–
–
Moderate risk Varnish at
6 monthly
intervals
Varnish or gel –
at 6 monthly
intervals
High risk
Varnish or gel
6 monthly
intervals
Varnish at
6 monthly
intervals Varnish or gel
at 3-6 monthly
intervals
Further information
Can be obtained from the
Dental Practice Education Research Unit,
School of Dentistry,
The University of Adelaide, Australia 5005.
Phone (08) 8303 4045 toll-free 1800 805 738
fax (08) 8303 4858
email [email protected]
References
Australian Research Centre for Population Oral Health 2006. The use of
fluorides in Australia: Guidelines. Australian Dental Journal 51(2):195–9.
Burt BA & Eklund SA 1992. Dentistry, dental practice and the community
(4th edn). Philadelphia: WB Saunders Company.
Chu CH, Lo EC & Lin HC 2002. Effectiveness of silver diamine fluoride and
sodium fluoride varnish in arresting dentin caries in Chinese pre-school
children. Journal of Dental Research 81(11):767–70.
Derks A, Katsaros C, Frencken JE, van't Hof MA & Kuijpers-Jagtman AM
2004. Caries-inhibiting effect of preventive measures during orthodontic
treatment with fixed appliances: A systematic review. Caries Research
38(5):413–20. (Review).
Dijkman TG & Arends J 1988. The role of `CaF2-like' material in
topical fluoridation of enamel in situ. Acta Odontologica Scandinavica
46:391–7.
Ekstrand J, Koch G & Petersson LG 1983. Plasma fluoride concentration
in pre-school children after ingestion of fluoride tablets and toothpaste.
Caries Research 17:379–84.
Ekstrand J, Koch G, Lindgren LE & Petersson LG 1981. Pharmacokinetics
of fluoride gels in children and adults. Caries Research 15:213–20.
Ekstrand J, Koch G & Petersson LG 1980. Plasma fluoride concentration
and urinary fluoride excretion in children following application of the
fluoride-containing varnish Duraphat. Caries Research 14:185–9.
Hamilton IR 1990. Biochemical effects of fluoride on oral bacteria. Journal
of Dental Research 69: (Spec. No. 660–7) 682–3. (Review).
Houpt M, Koenigsberg S & Shey Z 1983. The effect of prior toothcleaning
on the efficacy of topical fluoride treatment: two-year results. Clinical
Preventive Dentistry 5:8–10.
Jiang H, Bian Z, Tai BJ, Du MQ & Peng B 2005. The effect of a bi-annual
professional application of APF foam on dental caries increment in primary
teeth: 24-month clinical trial. Journal of Dental Research 84(3):265–8.
Leake JL 2001. Clinical decision-making for caries management in root
surfaces. Journal of Dental Education. 65(10):1147–53.
Marinho VCC, Higgins JPT, Logan S & Sheiham A 2002a. Fluoride
varnishes for preventing dental caries in children and adolescents.
Cochrane Database of Systematic Reviews, Issue 3, Art. No. CD002279.
DOI: 10.1002/14651858.CD002279.
Marinho VCC, Higgins JPT, Logan S & Sheiham A 2002b. Fluoride gels
for preventing dental caries in children and adolescents. The Cochrane
Database of Systematic Reviews, Issue 1, Art. No. CD002280. DOI:
10.1002/14651858.CD002280.
Mellberg JR 1990. Evaluation of topical fluoride preparations. Journal of
Dental Research 69 (Spec. No. 771–9):820–3. (Review).
Newbrun E 2001. Topical fluorides in caries prevention and management:
A North American perspective. Journal of Dental Education
65(10):1078–83.
Pienihäkkinen K & Jokela J 2002. Clinical outcomes of risk-based caries
prevention in preschool-aged children. Community Dentistry and Oral
Epidemiology 30(2):143–50.
Ripa LW 1990. An evaluation of the use of professional (operator-applied)
topical fluorides. Journal of Dental Research 69 (Spec. No. 786–96):
(820–3). (Review).
Stecksén-Blicks C, Renfors G, Oscarson ND, Bergstrand F & Twetman S
2007. Caries-preventive effectiveness of a fluoride varnish: a randomized
controlled trial in adolescents with fixed orthodontic appliances. Caries
Research 41(6):455–9. Epub 2007 Sep 7.
Truin GJ & van 't Hof MA 2005. Professionally applied fluoride gel in lowcaries 10.5-year-olds. Journal of Dental Research 84(5):418–21.
Truin GJ & van 't Hof MA 2007. The effect of fluoride gel on incipient
carious lesions in a low-caries child population. Community Dentistry and
Oral Epidemiology 35(4):250–4.
van Rijkom HM, Truin GJ & van 't Hof MA 1998. A meta-analysis of clinical
studies on the caries-inhibiting effect of fluoride gel treatment. Caries
Research 32(2):83–92.
Wei SH & Chik FF 1990. Fluoride retention following topical fluoride foam
and gel application. Pediatric Dentistry 12(6):368–74.
Weintraub JA, Ramos-Gomez F, Jue B, Shain S, Hoover CI, Featherstone JD
& Gansky SA 2006. Fluoride varnish efficacy in preventing early childhood
caries. Journal of Dental Research 85(2):172–6.
Acknowledgement
Professor Gary Slade for material on fluoride varnish
presented at the Consensus Meeting on Fluorides in
Adelaide, Australia, 2005.
Applications in the dental surgery
PROFESSIONAL FLUORIDE APPLICATIONS
IN THE DENTAL SURGERY
Professional application of fluoride products have been
used successfully in dental surgeries for many years. This
information sheet aims to update material relating to the use
of fluoride products in the dental surgery.
Professional use of fluoride products
Fluoride products used in dental surgeries include gels and
varnish with, on the whole, high doses of fluoride varying
from 9,000 ppm to 23,000 ppm. Since the introduction of
community water fluoridation and the widespread availability
of fluoride toothpastes, their application has been restricted
to those patients with moderate to high caries risk. There
is now substantial evidence that those at low risk of dental
caries are unlikely to benefit from professional application of
topical fluoride (Truin & van’t Hof 2005; Truin et al. 2007; van
Rijkom et al. 1998).
Action of fluoride in preventing and
controlling dental caries
Professionally applied fluorides can be used for both primary
and secondary prevention of caries. Primary prevention
concerns prevention of carious lesions that develop on sound
tooth structure, while secondary prevention is remineralisation
treatment of the initial, precavitated lesion and of root caries.
The recommended frequency of application of both fluoride
varnish and fluoride gels is two to four times per year.
Professionally applied fluorides have a high concentration of
fluoride ions. When it comes into contact with the tooth surface,
this high concentration fluoride does not enter the crystalline
structure of the enamel (Dijkman et al. 1988). Rather, it forms
a reservoir of calcium fluoride at the tooth surface which is
available to release fluoride for remineralisation when the pH
in plaque falls.
Houpt et al. (1983) and Mellberg (1990) found that removal
of plaque through prophylaxis is not necessary prior to the
professional application of fluoride. As fluoride becomes
concentrated in dental plaque, the metabolic activity of
cariogenic bacteria that produce acid from carbohydrates is
reduced, thus affecting the bacterial production of adhesive
polysaccharides (Hamilton 1990).
COLGATE DENTAL EDUCATION PROGRAMS
A joint program by Colgate Oral Care and The University of Adelaide
Fluoride varnish
Fluoride varnish contains 23 mg/mL fluoride ion suspended
in an alcohol and resin base. It is applied directly to dried
teeth, where it forms a waxy film that adheres to the
teeth until it is worn off by chewing or brushing. Although
fluoride varnish contains a high concentration of fluoride
ions, it sets immediately on contact with saliva such that
little is swallowed. Fluoride varnish may be applied to all
teeth or as a spot application on localised areas.
Effectiveness
Varnish has been shown to be effective when applied
approximately every 6 months or annually, although the
latter period results in a reduced effect. There is good
evidence that varnish is effective for prevention of dental
caries in children and adolescents, even as young as
12 months, where other forms of professionally applied
fluoride are contraindicated (Weintraub et al. 2006).
Varnish can prevent 46% of caries that develops in the
permanent dentition and 33% in the deciduous dentition
(Marinho et al. 2002a). It offers an alternative vehicle for
caries prevention for individuals deemed to be at high risk
and in whom other fluoride modalities are not available or
suitable. Application twice a year has not been linked to
an increased risk of fluorosis or toxic events.
Safety
A major concern in relation to fluoride varnishes (and gels)
is the high fluoride concentration and the possibility of
fluorosis or more serious toxicity. Ekstrand et al. (1980)
compared fluoride levels in peripheral blood and urine in
children for up to 48 hours following both fluoride varnish
and fluoride gel applications. The application of varnish
resulted in a peak plasma concentration 2 hours later in
the range 3.2–6.3 µmol/L of fluoride, while peripheral
blood levels following application of gel were 16–76
µmol/L after 1 hour. The fluoride varnish levels were
comparable to those for toothpaste or the ingestion of a
1 mg fluoride tablet. The authors suggested that the lower
levels for varnish were the result of slower ingestion of
the retained varnish as it is removed from the enamel
hours after application and the slower absorption of
varnish within the gut.
Use in the dental surgery
Within the dental surgery, use 0.25 mL of varnish for a full
mouth application for a preschool child and up to 0.40 mL
for an adult.
Beginning with the posterior teeth, dry the teeth with
gauze or cotton roll and then paint fluoride varnish onto
the occlusal surfaces. Because the varnish will only stick
well if the tooth is dry, you will need to dry a few teeth at
a time and then paint, and then dry more teeth and paint
them. The child can have a rest before you move on to the
contra-lateral posterior teeth, the upper anterior teeth, the
palatal and labial surfaces, and the lower anterior teeth.
Advise parents/patients:
• to wait at least 30 minutes before eating, and longer if
possible
• that the teeth will look yellow for a few days
• not to brush the teeth until the next day
• that best results are obtained if teeth are painted twice
a year, about once every 6 months.
Fluoride gels and foams
Fluoride gels for prevention of dental caries were developed
to enable topical application to the whole dentition
simultaneously. The gels were formulated so that they
flowed under pressure and could be applied using a tray.
They were made widely available in the mid 1960s. More
recently, a fluoride foam which performs similarly to a gel
has been marketed in some countries. Their attraction is
that less of the foam is used, which may reduce the amount
swallowed by young children (Wei et al. 1990). There are
few clinical studies of their effectiveness, although a study
by Jiang et al. (2005) found foams to be effective in the
primary dentition.
Neutral vs acidulated
Acidulated-phosphate fluoride (APF) with 1.23% fluoride ion
and a pH of approximately 3 was developed because it
allows greater uptake of fluoride by enamel in an acidic
environment.
Neutral fluoride gels have become more popular in recent
years for use in mouths with high levels of acidity. Sodium
fluoride neutral gels of 5,000 ppm for daily home use and
12,000 ppm for professional application at 3–4-monthly
intervals have been available since the early 1990s for
individuals with high caries rates, xerostomia or multiple
sites with active root caries. However, there is little
evidence of their effectiveness compared to other fluoride
modalities.
Effectiveness
The Cochrane review by Marinho et al. (2002b) found that
6-monthly applications of fluoride gels applied for 4 minutes
or more resulted in a 28% reduction in caries experience in
the permanent dentition. This confirms work by van Rijkom
et al. (1998), Newbrun (2001) and Ripa (1990).
There is little evidence available on the use and
effectiveness of fluoride gels in the deciduous dentition
or on acceptability or adverse events. In addition, there is
little clinical evidence on the effectiveness of fluoride gels
applied for shorter periods of time, e.g. 1 minute.
Use in the dental surgery
Within the dental surgery the most frequent fluoride therapy
is the application of a fluoride gel. The operator should
remember that each millilitre of gel contains 12.3 mg of
fluoride. With quantities of APF gel dispensed usually in the
vicinity of 5 mL, this raises concerns about toxicity in young
children. For this reason the following recommendations
should be followed:
• do not use fluoride gel in children younger than 10 years
of age;
• minimise the amount of gel used and in no case exceed
a total of 2.0 mL per tray;
• seat the patient in an upright position and incline the
head slightly forward;
• apply the fluoride gel for 4 minutes;
• use a saliva ejector during the procedure;
• instruct the patient to expectorate for 30 seconds after
the procedure; and
• preferably use a tray with absorbent liners.
Safety
Ekstrand et al. (1981) conducted analyses of peripheral
blood and urine in children after application of APF gel.
Peak plasma fluoride concentrations of 16–76 µmol/
mL for APF gels found 1 hour after application were
considerably higher than the 3.2–6.3 – µmol/mL found
within 2 hours of varnish treatment (Ekstrand et al. 1983).
These data indicate that the risk of acute toxic reactions
with gels is greater than with varnish as it is more readily
swallowed and absorbed. Hence, the use of fluoride gels is
contraindicated in children below the age of 10 years.
Fluoride prophy paste
Prophy pastes containing fluoride are sometimes used
for dental prophylaxis. Their function is to restore the
concentration of fluoride in the surface layer of enamel
which is removed by polishing. However, the abrasive
paste, which contains varying levels of fluoride (4,000–
20,000 ppm), is not an adequate substitute for fluoride gel
or varnish in treating persons at high risk for dental caries
(Mellberg 1990).
Topical fluoride as a treatment of
dental caries
Deciduous caries
Fluoride varnish applied 3-monthly has been recommended
as a treatment for deciduous caries (Newbrun 2001;
It is the responsibility of the dental practitioner to ensure
they are aware of the concentrations and the appropriate
use and storage of the products they are administering
and prescribing, and to pass this information on to their
patients. Small amounts of these tasty materials can be
ingested by curious young children looking for interesting
things in a dental surgery.
Pienihäkkihen et al. 2002). Other work suggests that silver
diamine fluoride may be even more effective (Chu et al.
2002), but has the side effect of blackening the dentine.
More research is needed in this area.
Permanent caries
Use of professionally applied fluorides at least twice-yearly
is now commonly recommended for the management
of active caries prior to clinical cavitation. Fluoride
varnishes and gels have been shown to be effective in
the remineralisation of such lesions on smooth surfaces
of permanent teeth, particularly in moderate-risk patients
(Newbrun 2001). High-risk patients should also receive high
concentration fluoride treatment, but may need additional
measures to control their disease.
Two safety issues need to be considered—toxicity and
fluorosis. The probable toxic dose is 5 mg of fluoride per
kilogram of body weight. The dose generally recognised as
leading to fluorosis is 0.05–0.07 mg/kg body weight/day
(Burt et al. 1992) at the time of enamel calcification.
Calculation of dosage
In calculating dosage, a number of factors need to be
considered:
• the amount and type of fluoride in the product
• the amount of fluoride swallowed, which varies with the
age of the child (younger children have less control of
the swallowing reflex) and with the amount placed in
the mouth and the ability to swallow the material (more
difficult with fluoride varnishes which adhere well to the
dry tooth and break down slowly)
• the rate of absorption from the gut (the bioavailability)
of the product, which will be important although less is
known about this factor.
APF is the only product for which a percentage of fluoride is
given (1.23%). However, per cent fluoride can be calculated
when ppm is known: in Australia junior toothpaste is 0.04–
0.05% (400–500 ppm) and normal toothpaste is 0.1%
(1000 ppm).
Orthodontic associated demineralisation
Demineralised areas associated with orthodontic bands
and brackets have long been an unwanted outcome
in some patients under orthodontic care. Recent work
confirms the role of fluoride varnish in reducing both the
size and likelihood of occurrence of demineralised areas
associated with bonded brackets (Stecksén-Blicks et al.
2007; Derks et al. 2004).
Root caries
Studies provide consistent evidence showing that
professional fluoride applications at least twice a year,
regular home use of high-dose fluoride toothpastes, and
home use of fluoride gels or daily fluoride mouth rinsing
result in the remineralisation of root caries (Leake 2001).
Safe use of fluoride in dental clinics
The amount of fluoride ion available varies with the
particular compound. The conversion factors and fluoride
levels in dental products are listed in Table 1.
When handled appropriately by practitioners and patients,
fluoride products pose very little risk of adverse effects.
Table 1:
Fluoride levels in various dental products
Form of fluoride (F)
Conversion factors
Typical products
Per cent F
ppm F
Fluoride gel:
acidulated phosphate fluoride
1.23% F
1.23% F
12,300
Fluoride varnish:
sodium fluoride
2.2 mg NaF = 1 mg F -
5% NaF
2.26% F
22,600
Mouthrinse:
sodium fluoride
2.2 mg NaF = 1 mg F -
0.2% NaF
0.09% F
900
Adult toothpaste
monofluorophosphate (MFP)
7.6 mg MFP = 1 mg F -
0.76% MFP
0.1% F
1,000
Junior toothpaste
monofluorophosphate
7.6 mg MFP = 1 mg F -
0.304% MFP
0.04% F
400
An example showing calculation of the amount ingested by a child brushing with an adult toothpaste and swallowing 20%
is illustrated by the following two equations:
% F in the compound ingested (0.1%) x quantity used in the treatment (0.25gm) = F dose (0.25 mg)
F dose (0.25 mg) x amount actually swallowed (20%) = mg F ingested (0.05 mg)
Emergency recommendations for fluoride overdose are presented in Table 2.