Faculty of Engineering at Helwan 2011

Transcription

2011
Journal
I.F =0.371
Faculty of Engineering at Helwan
EUROPEAN TRANSACTIONS ON ELECTRICAL
Eurp. Trans. Electr. Power (2011)
Publish online in wiley online library
(wileyonlinelibrary.com).Dol:10.1002/step.647
Research
Title
LABORATORY INVESTIGATION FOR POWER TRANSFORMER PROTECTION
TECHNIQUE BASED ON POSITIVE SEQUENCE ADMITTANCE APPROACH
Authors
Moustafa Mohammed Eissa, El Hassan Shehab-Eldin, Mohmoud Elshahat Masoud and
Ahmed Sayed Abd-Elatif
Affiliation
Department of Electrical Engineering, Faculty of Engineering, Helwan University,
Helwan, Cairo, EGYPT
Abstract
This paper presents a new digital technique for transformer protection. The technique uses the
accumulated positive sequence admittance at the two sides of the power transformer. The
instantaneous measurements of phase voltage and line current signals at the transformer terminals
are used to calculate the accumulated positive sequence admittances. A 500/230-kV YIY transformer
connected to a 230-kV power system is simulated using MATLAB/SIMIULlNK tool. The method
depends on standalone decision at the two terminals of power transformer. A real-time investigation
for power transformer in normal and abnormal conditions based on experimental setup is given. The
experimental setup uses a transformer of (5 kVA, 220/110 V) for testing purposes. The simulated and
experimental results indicated that the proposed technique is stable, reliable, and fast during the
discrimination between internal and external faults, magnetizing inrush currents, and switching on
internal faults.
Key words
Power transformer; instantaneous voltage and current measurements; positive
sequence admittances; accumulated admittances; Lab-View; data acquisition; and
experimental setup
2011
Journal
I.F =1.694
Materials and Design 32 (2011) 146-153
Research
Title
PROCESSING OF POROUS TI AND TI5MN FOAMS BY SPARK PLASMA SINTERING
Authors
Ahmed Ibrahima, Faming Zhang b, Eileen Otterstein b, Eberhard Burkel b
a Department
Affiliation
of Mechanical Engineering, Faculty of Engineering, Helwan University,
Egypt
b Institute of Physics, University of Rostock, August Bebel Str. 55, 18055 Rostock,
Germany
c Abdulaziz University Jeddah, B.O, 80217, Jeddah 21589, Saudi Arabia
Abstract
Titanium and its alloys are one of the best metallic biomaterials to be used for implant
application. In this study, porous Ti and Ti5Mn alloy with different porosities were successfully
synthesized by powder metallurgy process with the addition of NH4HC03 as space holder and
TiHz as foaming agent. The consolidation of powder was achieved by spark plasma sintering
process (SPS) at 16 MPa and pressureless conditions. The morphology of porous structure was
investigated by using scanning electron microscopy (SEM) and X-ray micro-tomography (J.!-CT).
Nano-indentation tester was used to evaluate Young's modulus of the porous Ti and Ti5Mn alloy.
Experimental results showed that pure Ti sample, which sintered under pressure of 16 MPa, full
relative density was achieved even at a relative low sintering temperature 750°C; however, in the
case of pressureless condition at sintering temperature 1000 DC the porosity was 53% and
Young's modulus was 40 GPa. The Ti5Mn alloy indicated a good pore distribution, and the
porosity decreased from 56% to 21 % by increasing the sintering temperature from 950°C to
1100 0C. Young's modulus was increased from 35 GPa to 51.83 GPa with increasing of the
sintering temperatures from 950°C to 1100 dc.
Key words
Porous material Spark plasma sintering Biomedical applications
2011
Journal
I.F =4.232
IEEE journal on selected areas in communications, vol. 28, NO.7, Septemerer 2010
Research
Title
HARNESSING BATTERY RECOVERY EFFECT IN WIRELESS SENSOR NETWORKS:
EXPERIMENTS AND ANALYSIS
Authors
Chi-Kin Chau, Fei Qin, Samir Sayed, Muhammad Husni Wahab, Yang Yang
Affiliation
C-K. Chau is with Computer Laboratory. University of Cambridge, UK (e-mail:
[email protected])
F Qin and S. Sayed are with Electronic & Electrical Engineering Department, University
College London, UK (e-mail: {f.qin, s.sayed} @ee.ucl.ac.uk)
M. H. Wahab is with the Computer Science Department, University College London (email: [email protected]).
Y. Yang is with Shanghai Research Center for Wireless Communications (WiCO). SIMIT,
Chinese Academy of Sciences, China (e-mail: yang. yan @shrewe.org).
Abstract
Abstract-Many applications of wireless sensor networks rely on batteries. But most batteries are not
simple energy reservoirs, and can exhibit battery recovery effect. That is, the deliverable energy in a
battery can be self-replenished, if left idling for sufficient time. As a viable approach for energy
optimisation, we made several contributions towards harnessing battery recovery effect in sensor
networks. 1) We empirically examine the gain of battery runtime of sensor devices due to battery
recovery effect, and affirm its significant benefit in sensor networks. \Ve also observe a saturation
threshold, beyond which more idle time will contribute only little to battery recovery. 2) Based on
our experiments, we propose a Markov chain model to capture battery recovery considering
saturation threshold and random sensing activities, by which we can study the effectiveness of duty
cycling and buffering, 3) We devise a simple distributed duty cycle scheme to take advantage of
battery recovery using pseudo-random sequences, and analyse its trade-oil" between the induced
latency of data delivery and duty cycle rates,
Key words
Wireless Sensor Networks, Energy Optimization, Battery Recovery Effect, Duty Cycle
2011
Journal
I.F =0.683
Research
Title
Authors
Affiliation
Mobile Netw Appl (2011) 16:4-16
BTAC: A BUSY TONE BASED COOPERATIVE MAC PROTOCOL FOR WIRELESS
LOCAL AREA NETWORKS
a Samir
Gaber Sayed, b Yang Yang and c Jing Xu
b Department of Electronic and Electrical Engineering, University College London,
London WClE 7JE, UK, e-mail: [email protected]
a Department of Communications and Electronics Engineering, Helwan University,
Helwan, Egypt, e-mail: [email protected]
c Shanghai Research Center for Wireless Communications (WiCO), 280-1 Linhong
Road, Changning, Shanghai 200335, China
Abstract
Cooperative communications has been actively studied as an effective approach to achieve multiuser/spatial diversity gains and better overall system performance by coordinating multiple users in
a dynamic wireless network to share their resources and capabilities. Based on the concept of
cooperative communications, this paper proposes and analyzes a Busy Tone based cooperative
Medium Access Control (MAC) protocol, namely BTAC, for multi-rate Wireless Local Area Networks
(WLANs). A cross-layer Markov chain model is then developed to evaluate the performance of BT AC
under dynamic wireless channel conditions. Analytical and simulation results show our BT AC
protocol is simple, robust, fully compatible with the IEEE 802.11b standard and can achieve better
throughput and delay performance than the standard Distributed Coordination Function (DCF)
protocol and the recently-proposed Coop MAC protocol.
Key words
cooperative communications ·wireless local area network- IEEE 802.11 .medium ccess
control
2011
Journal
I.F =3.745
Progress In Electromagnetic Research B, Vol. 37, 21-42, 2012
Research
Title
AN INTERACTION STUDY BETWEEN PIFAS HANDSET ANTENNA AND A HUMAN
HAND-HEAD IN PERSONALCOMMUNICATIONS
Authors
a
A. M. Montaser, b K. R. Mahmoud, and c H. A. Elmikati
Sohag University, Sohag, Egypt
Department of Electronics and Communications Engineering, Faculty 0f
Engineering helwan university , Cairo, Egypt
c Mansoura University, Mansoura 35516, Egypt
a
Affiliation
b
Abstract
In this paper, the interaction of a planar inverted-F antennas array, mounted on a mobile handset,
with a human hand-head phantom is investigated in the 1.9GHz band. The hybrid approach involving
the particle swarm optimization (PSO) and Nelder-Mead (NM) algorithm is considered to optimize
the complex excitations of the adaptive array elements in a mutual coupling environment for
different beam forming synthesis. Firstly, the effect of the human hand on the handset radiation
characteristics is studied. Then, the spatial-peak specific absorption rate (SAR) values of 2- and 4element PIFA arrays for mobile handset in the vicinity of a human hand-head are evaluated
numerically for different scenarios. The antenna is analyzed completely using finite difference time
domain (FDTD) method while the interaction is performed using the CST Microwave Studio software.
Key words
F antennas array, mobile handset, PIFA arrays, CST Microwave Studio software
2010
Journal
I.F =3.745
Progress In Electromagnetics Research, PIER 100, 105-117, 2010
Research
Title
DESIGN OPTIMIZATION OF A BOW-TIE ANTENNA
FOR 2.45 GHz RFID READERS USING A HYBRID BSONM ALGORITHM
Authors
K. R. Mahmoud
Affiliation
Electronics & Communications Department, Faculty of Engineering
Helwan University Egypt
Abstract
Recently the Bacterial foraging optimization algorithm (BFA) has attracted a lot of attention as a highperformance optimizer. This paper presents a hybrid approach involving Bacterial Swarm
Optimization (BSO) and Nelder-Mead (NM) algorithm. The proposed algorithm is used to design a
bow-tie antenna for 2.45GHz Radio Frequency Identification (RFID) readers. The antenna is analyzed
completely using Method of Moments (MoM), then the MoM code is coupled with the BSO-NM
algorithm to optimize the antenna. The simulated antenna and the optimization algorithm programs
were implemented using MATLAB version 7.4. To verify the validity of numerical simulations, the
results are compared with those obtained using Feko Software Suite 5.3.
Key words
Bacterial foraging optimization algorithm, BSO, Numerical simulation
2011
Faculty of Engineering helwan
Journal
I.F =0.844
Electromagnetics, 31:578-592, 2011
Research Title
CENTRAL FORCE OPTIMIZATION: NELDER-MEAD HYBRID ALGORITHM FOR
RECTANGULAR MICROSTRIP ANTENNA DESIGN
Authors
K. R. MAHMOUD
Affiliation
Electronics and Communications Department, Faculty of Engineering,
Helwan University, Helwan, Egypt
Abstract
In this article, an efficient global hybrid optimization method is proposed combining central force
optimization as a global optimizer and the Nelder-Mead algorithm as a local optimizer: After the
final global iteration, a local optimization can be followed to further improve the solution obtained
from central force optimization. The convergence capability of the hybrid central force optimizationNelder-Mead approach is compared with other recent evolutionary-based algorithms using 13
benchmark functions grouped into unimodal and multimodal functions. In addition, the proposed
algorithm is used to calculate accurately the resonant frequency and feed-point position of
rectangular microstrip patch antenna elements with various dimensions and various substrate
thicknesses. It is found that, in addition to decreasing the required evaluation number and the
required processing time, excellent results are obtained.
Key words
Central force optimization, Nelder-Mead algorithm. rectangular microstrip
antenna, resonant frequency, feed position
2010
Journal
I.F =1.2
IEEE TRANSACTIONS ON POWER DELIVERY. VOL. 25. NO. I. JANUARY 2010
Research Title
A NOVEL BACK UP WIDE AREA PROTECTION TECHNIQUE FOR POWER
TRANSMISSION GRIDS USING PHASOR MEASUREMENT UNIT
Authors
M. M. Eissa, M. Elshahat Masoud, and M. Magdy Mohamed Elanwar
Affiliation
M. M. Eissa was with the Faculty of Engineering, Electrical Engineering
Department, Helwan University, Cairo 11795, Egypt.
M. E. Masoud and M. M. M. Elanwar are with the Faculty of Engineering,
Power Department, Helwan University at Helwan, Cairo 11795, Egypt.
Abstract
Current differential protection relays are widely applied to the protection of electrical plant due to
their simplicity, sensitivity and stability for internal and external faults. The proposed idea has the
feature of unit protection relays to protect large power transmission grids based on phasor
measurement units. The principle of the protection scheme depends on comparing positive sequence
voltage magnitudes at each bus during fault conditions inside a system protection center to detect the
nearest bus to the fault. Then the absolute differences of positive sequence current angles are
compared for all lines connecting to this bus to detect the faulted line. The new technique depends on
synchronized phasor measuring technology with high speed communication system and time
transfer GPS system. The simulation of the interconnecting system is applied on 500 kV Egyptian
network using Matlab Simulink. The new technique can successfully distinguish between internal and
external faults for interconnected lines. The new protection scheme works as unit protection system
for long transmission lines. The time of fault detection is estimated by 5 msec for all fault conditions
and the relay is evaluated as a back up relay based on the communication speed for data transferring.
Key words
Digital protection, discreet Fourier transform,(GPS) system, synchronized phasor
measurement, time synchronization
2012
Journal
I.F =2.090
Research Title
Authors
Affiliation
Materials Science and Engineering A 534 (2012) 514-520
EFFECT OF COOLING RATE CONTROLLED FORGING ON PROPERTIES OF LOW
CARBON MULTI-MICROALLOYED
T. EI-Bitar a, N. Fouad b, A.I. Zaky a, S.A. EI-Rady b
a Central Metallurgical R&D Institute (CMRDI). p.a. Box 87. Helwan, Cairo. Egypt
b Mechanical Engineering Department. Faculty of Engineering. Helwan
University. 1 Sherif Street. Helwan. Cairo 11792. Egypt
Abstract
Two low carbon steel grades were used in the present investigation. One of them was microalloyed
with Ti, V. and Nb. Both steel grades were subjected to a controlled hot forging followed by either
cooling in air or quenching water. The microstructures of all TMT conditions are dominated by
ferrite phase with different morphologies and grain sizes according to both chemical composition
and cooling rate. Polygonal ferrite is considered to be a dominated phase of air cooled
microstructures for both steel grades that is responsible for decreasing the hardness. Yield . and
tensile strength with the attendant increase in ductility. Water quenching leads to a formation of
relatively fine polygonal ferrite in low carbon steel or transformation into acicular ferrite in low
carbon microalloyed steel. Relatively fine polygonal ferrite and acicular ferrite increase strength but
decrease ductility. The cooling rate has a negligible effect on the impact toughness at room
temperature.
Key words
Low carbon (LC) steel Low carbon microalloyed (LC-MA) steel
2011
Journal
I.F =1.471
Research Title
Authors
Affiliation
Ceramics International 36 (2010) 1327-133
www.elsevier.comllocate/ceramint
INVESTIGATION OF THE EFFECT OF ZrO₂/AND ZrO₂/AI₂O₃ ADDITIONS ON
THE HOT-PROPERTIES OF EQUIMOLECULAR MIXTURES OF α- AND β-Si₃N₄
E.M.M. Ewais a , M.A.A. Atria b, A. Abousree-Hegazyb, R.K. Bordia C
a Refarctory & Ceramic Materials Lab (RCML). Central Metallurgical R&D Institute.
P.O. Box 87 Helwan, Cairo, Egypt
bMechanical Engineering Department, Faculty of Engineering, Helwan University,
P.O. Box 11792 Helwan, Cairo, Egypt
C Department of Materials Science and Engineering, University, of Washington,
Roberts Hall, Seattle, WA 98195, USA
Abstract
In this work, hot-pressing of equimolecular mixtures of a- and Jj-Si3N4 was performed with addition
of different amounts of sintering additives selected in the Zr0₂-A1₂0₃ system. Phase composition and
microstructure of the hot-pressed samples was investigated. Densification behavior, mechanical and
thermal properties were studied and explained based on the microstructure and phase composition.
The optimum mixture from the Zr0₂-A1₂0₃ system for hot-pressing of silicon nitride to give high
density materials was determined. Near fully dense silicon nitride materials were obtained only with
the additions of zirconia and alumina. The liquid phase formed in the zirconia and alumina mixtures
is important for effective hot-pressing. Based on these results, we conclude that pure zirconia is not
an effective sintering additive. Selected mechanical and thermal properties of these materials are also
presented. Hot-pressed Si3N4 ceramics, using mixtures from of Zr0₂/Al₂0₃ as additives, gave fracture
toughness, K₁c in the range of 3.7-6.2 MPa m ₁ ̸ ₂ and Vicker hardness values in the range of 6-12
GPa. These properties compare well with currently available high performance silicon nitride
ceramics. We also report on interesting thermal expansion behavior of these materials including
negative thermal expansion coefficients for a few compositions.
Key words
A. Hot-pressing; D. Si3N4; D. Zr02; D. A1203; C. Mechanical properties; C. Thermal
properties; Microstructure
2011
Faculty of Engineering at EI-Mattaria
Journal
I.F =3.565
Energy 36 (2011) 2788-2795
Contents lists available at Science Direct Energy
journal homepage: www.elsevier.comllocate/energy
Research
Title
EXPERIMENTAL INVESTIGATION OF A VAPOR COMPRESSION HEAT PUMP
USED FOR COOLING AND HEATING APPLICATIONS
Authors
M. Fatouh and E. Elgendy
Mechanical Power Engineering Department, Faculty of Engineering at EI-Mattaria.
P.O.1I718 (Masoken El-Helmia), Cairo. Egypt
Affiliation
Abstract
The present work aims at evaluating the performance characteristics of a vapor compression heat
pump (VCHP)for simultaneous space cooling (summer air conditioning) and hot water supply. In
order to achieve this objective. a test facility was developed and experiments were performed over a
wide range of evaporator water inlet temperature (14:26°C) and condenser water inlet temperature
(22:34 'C). R134awas used as a primary working fluid whereas water was adopted as a secondary
heat transfer fluid at both heat source (evaporator) and heat sink (condenser) of the heat pump.
Performance characteristics of the considered heat pump were characterized by outlet water
temperatures. water side capacities and coefficient of performance (COP)for various operating
modes namely: cooling. Heating and simultaneous cooling and heating. Results showed that COP
increases with the evaporator water inlet temperature while decreases as the condenser water inlet
temperature increases. However. The evaporator water inlet temperature has more effect on the
performance characteristics of the heat pump than that of condenser water inlet temperature.
Actual COP of cooling mode between 1.9 to 3.1 and that of heating mode from 2.9 to 3.3 were
obtained. Actual simultaneous COP between 3.7 and 4.9 was achieved.
Key words
R134a Heat pump Performance Cooling Heating Simultaneous
2011
Journal
I.F =3.565
Research
Title
Authors
Affiliation
Energy 36 (2011) 2883-2889 Energy
Contents lists available at Science Direct
journal home page: www.elsevier. comll ocate /energy
PERFORMANCE OF A GAS ENGINE DRIVEN HEAT PUMP FOR HOT WATER
SUPPLY SYSTEMS
E. Elgendy a, J. Schrmidt a, A. Khalil b and M. Fatouh c
a institute of Fluid Dynamics and Thermodynamics. Faculty of Process and System
Engineering. Otto-von-Guericke University. Universitiitsplatz,
D-39106 Magdeburg. Germany
b Mechanical Power Engineering Department, Faculty of Engineering, Cairo
University, Giza 12316, Egypt
C Mechanical Power Engineering Department, Faculty of Engineering at EI-Mattaria,
Helwan University. Masaken EI-Helmia P.O., Cairo 11718,Egypt
Abstract
The present work aimed at evaluating the experimental performance of a gas engine heat pump for
hot water supply. In order to achieve this objective, a test facility was developed and experiments
were performed over a wide range of ambient air temperature (10.9-25.3 'C), condenser water inlet
temperature (33-49 QC)and at two engine speeds (1300 and 1750 rpm). Performance
characteristics of the gas engine heat pump were characterized by water outlet temperatures, total
heating capacity and primary energy ratio. The reported results revealed that hot water outlet
temperature between 35 and 70o C can be obtained over the considered range of the operating
parameters. Also, total heating capacity and gas engine heat recovery decrease by 9.3 and 27.7%,
respectively, while gas engine energy consumption increases by 17.5% when the condenser water
inlet temperature changes from 33 to 49°C. Total heating capacity, gas engine heat recovery and gas
engine energy consumption at ambient air temperature of 25.3 °C are higher than those at ambient
air temperature of 10.9 'C by about 10.9, 6.3 and 1.5% respectively. Moreover, system primary
energy ratio decreases by 15.3% when the engine speed changes from 1300 to 1750 rpm.
Key words
Gas engine heat pump Heating modeR410A Water heating Primary energy ratio
Heat recovery
2011
Journal
I.F =2.514
Research
Title
Authors
Affiliation
Journal of Hydrology
Volume 405, Issues 3–4, 5 August 2011, Pages 277–287
journal home page: www.elsevier.com/locate/jhydrol
ESTIMATION OF WATER QUALITY CHARACTERISTICS AT UNGAUGED SITES
USING ARTIFICIAL NEURAL NETWORKS AND CANONICAL CORRELATION
ANALYSIS
B. Khalil a, T.B.M.Ouarda b,c, and A. St-Hilaire c
a Irrigation and Hydraulics Department. Faculty of Engineering. Helwan University.
Cairo. Egypt
b Masdar Institute of Science& Technology. PO Box 54224, Abu Dhabi, United Arab
Emirates
C Canada Research Chair an the Estimation of Hydrometeorological Variables, INRSETE,490 de la Couronne Quebec, QC,Canada Gl K 9A9
Abstract
Three models are developed for the estimation of water quality mean values at ungauged sites.
The first model is based on artificial neural networks (ANN),the second model is based on
ensemble ANN(EANN) and the third model is based on canonical correlation analysis (CCA)and
EANN .The ANN and EANN models are developed to establish the functional relationship between
water quality mean values and basin attributes. In the CCA-based EANN model, CCA is used to
form a canonical attributes space using data from gauged sites. Then. an EANN is applied to
identify the functional relationships between water quality mean values and the attributes in the
CCA space. Four water quality variables are selected as output of these models. Variable selection
is based on principal component analysis. The water quality variables which showed the highest
loading factors in the first four components are selected. The three models are applied to 50
subcatchments in the Nile Delta, Egypt .A jackknife validation procedure is used to evaluate the
performance of the three models. The results show that the EANN model provides better
generalization ability than the ANN .However. the (CA-based EANN model performed better than
the other two models in terms of prediction accuracy.
Key word
Water quality Ungauged site Regional estimation Canonical correlation Artificial
neural networks Jackknife
2011
Journal
I.F =1.810
Research
Title
Authors
Faculty of Engineering at EI-Mattmria
J Environ Monit. 2011 Aug;13(8):2190-205. Epub 2011 Jun 15.
A STATISTICAL APPROACH FOR THE ASSESSMENT AND REDESIGN OF THE
NILE DELTA DRAINAGE SYSTEM WATER- QUALITY-MONITORING
LOCATIONS
B. Khalil a, T. B. M. J. Ouarda b,c and A. St-Hilaire c
Irrigation and hydraulics department, Faculty of Engineering
University, Cairo, Egypt. E-mail : [email protected]; 20 5 6070447
b Masdar Institute of Science & Technology, PO Box 54224, Abu Dhabi,
UAE. E-mail.·[email protected]
c Canada Research Chair on the Estimation of Hydrometeorological
Variables, INRS-ETE, 490 de la Couronne, Quebec, QC, Canada G1K
9A9. Esmail: [email protected]; [email protected]; Fax:
+14186542600; Te1:+1 4186543842
a
Affiliation
Abstract
There are several deficiencies in the statistical approaches proposed in the literature for the
assessment and redesign of surface water-quality-monitoring locations. These deficiencies vary
from one approach to another, but generally include: (i) ignoring the attributes of the basin being
monitored; (ii) handling multivariate water quality data sequentially rather than simultaneously;
(iii) focusing mainly on locations to be discontinued; and (iv) ignoring the reconstitution of
information at discontinued locations. In this paper, a methodology that overcomes these
deficiencies is proposed. In the proposed methodology, the basin being monitored is divided into
sub-basins, and a hybrid-cluster analysis is employed to identify groups of sub-basins with similar
attributes. A stratified optimum sampling strategy is then employed to identify the optimum
number of monitoring locations at each of the sub-basin groups. An aggregate information index is
employed to identify the optimal combination of locations to be discontinued. The proposed
approach is applied for the assessment and redesign of the Nile Delta drainage water quality
monitoring locations in Egypt. Results indicate that the proposed methodology allows the
identification of (i) the optimal combination of locations to be discontinued, (ii) the locations to be
continuously measured and (iii) the sub-basins where monitoring locations should be added. To
reconstitute information about the water quality variables at discontinued locations, regression,
artificial neural network (ANN) and maintenance of variance extension (MOVE) techniques are
employed. The MOVE record extension technique is shown to result in a better performance than
regression or ANN for the estimation of information about water quality variables at discontinued
locations.
Key word
statistical approaches, ANN, maintenance of variance extension, water quality
2011
Journal of Hydrology 386 (2010) 173- 185
journal homepage: www.elsevier.com/locate/j hyd rol
Journal of Hydrology 386 8173- 185
Journal
I.F =2.514
Research
Title
A STATISICAL APPROACH FOR THE RATIONALIZATION OF WATER-QUALITY
INDICATORS IN SURFACE WATER QUALITY MONITORING NETWORKS
Authors
Khalil B a,b, T.B.M.J. Ouarda b , A. St-Hilaire b, F. Chebana b
Affiliation
Irrigation and Hydraulics Department. Faculty of Engineering. Helwan University.
Cairo. Egypt
b Statistical Hydrology Chair. Canada Research Chair on the Estimation of
Hydrometeorological Variables. INRS-ITE. 490 de la Couronne Quebec, QC, Canada Cl
K 9A9
a
Abstract
Despite several decades of operation and the increasing importance of water quality monitoring
(WQM) networks, authorities still rely on subjective or semi-subjective decision processes to
identify the optimal combination of water quality variables to measure. For this purpose, a statistical
approach is developed for assessment and selection of the optimal combination of water quality
variables. The proposed approach overcomes deficiencies in the conventional correlationregression approach used to assess and eventually reduce the number of water quality variables in
WQM networks. For the reduction of water quality variables, criteria developed from recordaugmentation procedures are integrated with correlation analysis and cluster analysis to identify
highly associated water quality variables. This step is followed by the application of an information
performance index to systematically identify the optimal combination of variables to be
continuously measured and those to be discontinued. The linear regression and maintenance of
variance (MOVE) record-extension techniques are employed to reconstitute information about
discontinued variables. The proposed approach is applied for rationalization of the water quality
variables in the Nile Delta surface WQM network in Egypt. Results indicate that the proposed
approach represents a useful decision support tool for the optimized selection of water quality
variables. The MOVE record-extension technique is shown to result in better performance than
regression for the estimation of discontinued variables.
Key words
Sampling Water quality indicator Monitoring network Rationalization Record
extension Record augmentation Introduction
2011
Journal
I.F = 0.358
Research
Title
Authors
Affiliation
Advanced Composite Materials 20 (201l) 245-259
BEHAVIOUR OF CONCRETE BEAMS REINFORCED WITH HYBRID FIBER
REINFORCED BARS
a
Tarek A. Elsayed , A. M. Eldaly b, A. A. EI-Hefnawy b , band G. M. Ghanem a
a Faculty of Engineering, Helwan University, Cairo, Egypt
b Housing and Building National Research Center (HBNRC), Egypt
Abstract
Due to the linear elastic behavior of FRP bars, the flexural behavior of FRP reinforced beams exhibits
no ductility as occurs in the steel reinforced structures. In this paper, study of the enhancement of
the behaviour of concrete beams reinforced with FRP bars was carried out by testing nine beams
reinforced with locally produced hybrid fiber reinforced polymer (HFRP) bars. The used hybrid
fibers were aramid-glass and carbon-glass. Some of test specimens were reinforced by FRP bars
provided with anchorages along the bar length. Crack patterns, cracking and ultimate loads, and
deformation were observed and recorded for all tested beams. The effect of using the hybrid fiber
reinforced bars and the bar anchorage system were judged by comparing the behaviour of the tested
beams by two reference specimens, one reinforced by GFRP bars and the other one reinforced by
traditional steel bars. The comparison revealed that HFRP bars provided with the used bars
anchorage played a significant role in enhancing the behaviour of concrete beams reinforced with
FRP bars.
Key words
Semi-ductility, hybrid fiber reinforced polymers bars, RC beams, anchored bars,
GFRP, HFRP
2011
Journal
I.F =2.054
Energy Conversion and Management 52 (2011) 2288-2295
Energy Conversion and Management
journal homepage: www.elsevier.com/locate/enconman
Research
Title
EFFECTS OF WATER CONTAMINATION ON SUB COOLED FLOW BOILING HEAT
TRANSFER
Authors
A.B . Helali
Affiliation
Mech. Power Eng. Dept ., Faculty of Eng ., Helwan University. Cairo. Egypt
Abstract
An experimental investigation has been carried out to study the effect of adding four different
contaminants to distilled water on heat transfer under sub-cooled flow boiling conditions. Flow
boiling experimental test rig has been designed and constructed to study the effect of changing the
contaminant concentration and flow velocity. Lube oil. Nile river water tap water and sea water
were added at different concentrations to distilled water under sub-cooled flow boiling testing at
constant bulk temperature. The effect of flow velocity was also studied for three different
concentrations of 1%. 3% and 5% as compared to pure distilled water case. The heat flux applied
was in the range of 100-400 kW/m'. Flow velocities were changed from 1.2 to 2.5 m/s at constant
bulk temperature of 70°C. It was found that adding any of the contaminants at all considered
concentrations to distilled water impairs the heat transfer process substantially.
Key words
Water contamination Heat transfer Flow boiling Sub-cooled boiling Sea water River
water Tap water
2011
Journal
I.F =2.064
Eur. Phys. J. Appl. Phys. 55, 11101 (2011)
Research
Title
HYDRODYNAMIC STABILITY OF SELF GRAVITATING STREAMING
MAGNETIZED FLUID CYLINDER
Authors
S.S. Elazab1, S.A. Rahman2, A.A. Hasan3 and N.A. Zidan4
Affiliation
Mathematics Department, Women's University College, Am-Shams University,
Asmaa Fahmy Street, Heliopolis, Cairo, Egypt
2Engineering Physics and Mathematics Department, Faculty of Engineering, Ain
Shams University, Cairo, Egypt
3Basic and Applied Sciences department., College of Engineering and Technology,
Arab Academy for Science & Technology
and Maritime Transport (AAST), P.O. Box 20:33, Elhorria, Cairo, Egypt
4 Engineering Physics and Mathematics Department, Faculty of Engineering
(Mataria), Helwan University, 11321 Cairo, Egypt
1
Abstract
The magnetohydrodynamic stability criterion of self-gravitating streaming fluid cylinder under the
combined effect of capillary, inertia, pressure gradient and electromagnetic forces has been derived.
The results are discussed analytically and some data are verified numerically for different
parameters of the problem. The magnetic field is stabilizing, but the streaming is destabilizing while
the self-gravitating and capillary forces are stabilizing or destabilizing according to restrictions. The
stable and unstable domains are identified and moreover the influences of the magnetic field and
capillary forces on the self-gravitating instability of the model have been examined. The including of
the electromagnetic force together with both the capillary and self-gravitating forces improve the
instability of the model. However, the self-gravitating instability will never be suppressed whatever
are the effects of the capillary and MHD forces stabilizing effects.
Key words
Stability criterion, magnetic field, modeling, capillary and MHD
2010
Faculty of Science
Journal
I.F =1.214
World J Microbiol Biottlchnol (20 I0) 26: 1125-1133
Research
Title
CHARACTERIZATION OF A SYNECHOCYSTIS SP FROM EGYPT WITH THE
POTENTIAL OF BIOACTIVE COMPOUNDS PRODUCTION
Authors
Nermin Adel El Semary & Mai Abd El Naby
Department of Botany and Microbiology, Faculty of Science, Helwan University,
Ain Helwan 11795, Egypt
e-mail: [email protected];
[email protected]
Affiliation
Abstract
A polyphasic approach was employed to describe a unicellular coccoid cyanobacterium isolated from
Terraat El Khashab, Helwan, Egypt. The cells were characterized by their small diameter (1.9-2.2 um)
and lack of buoyancy. The cultures grew best at a temperature range of 20-40°C and moderate light
intensity (20-50 umol photon m-2 s-I). To verify its cyanobacterial nature, sequencing of 16S rRNA
gene using cyanobacterial specific primers was performed followed by a phylogenetic analysis. The
sequence best-matched Synechocystis sp. PCC6803 with 90% similarity. The phylogenetic analysis
placed the isolate within a major c1ade containing different Synechocystis isolates. The fatty acid
composition was rich in saturated fatty acids while polyunsaturated fatty acids were scarce. The
phytochemical screening revealed the presence of f1avenoids, alkaloids and saponins and absence of
tannins. Vitamin C was also present in a considerable quantity. Some of the lipophilic fractions
showed antimicrobial bioactivity against several pathogens. The pure bioactive compound from
highest bioactive fraction was identified as oleic acid amide (M. wt.28 I) using chemical analyses
including FIIIR, UV, proton H-NMR and GC-mass. The study highlights the importance of investigating
the biotechnological potential of microorganisms inhabiting unusual niches.
Key words
Synechocystis, Polyphasic description' Bioactive compound, UV, FIIIR, Proton NMR, GCmass and oleic acid amide
2010
Journal
I.F =0.350
Research
Title
Authors
Affiliation
Faculty of Science
Ann Microbiol (2010) 60:181-188
INVESTIGATING FACTORS AFFECTING GROWTH AND CELLULAR MCYB
TRANSCRIPTS OF MICROCY STIS AERUGINOSA PCC 7806USING REAL-TIME PCR
Nermin Adel El Semary
Helwan 11795, Egypt, e-mail: [email protected]
e-mail: [email protected]
Abstract
The effects of temperature and light intensity on microcystis aeruginosa PCC 7806 growth and
mcyB transcripts (as a function of microcystin biosynthesis) were investigated at the logarithmic and
stationary growth phases. The expression of the mcyB gene--one of the microcystin biosynthetic
genes-under different treatments was quantified using real-time PCR. The results showed that cell
number increased at 25°C with all light treatments. A significant positive correlation (P=0.060)
between mcyB transcripts and cell number was found, indicating the presence of coupling between
toxin biosynthesis and growth. The results also revealed that both temperature and growth phase
were significantly correlated with the number of mcyB transcripts (P=0.005 and 0.036, respectively),
with at least 67% of the variation attributable to these two factors alone. On the other hand, the effect
of the range of light intensities tested was overly non-significant. Application of high light intensity,
above saturation point for a prolonged period, was inhibitory to transcription of the mcyB gene.
Maximum mcyB transcript number was attained during stationary phase of a microcystis culture
grown at 25°C under medium light intensity. The high level of mcyB transcription during stationary
phase indicates an increase in the biosynthesis of micocystin. This possibly indicates the role of the
toxin as an alarming chemical that cells would release upon lysis/death.
Key words
Microcystis aeruginosa, mcyB, Light Microcystin, QRT-PCR, Temperature
2011
Faculty of Science
Journal
I.F =0.350
Annals of Microbiology, March 2012, Volume 62, Issue 1, pp 55-59
Research
Title
THE CHARACTERISATION OF BIOACTIVE COMPOUNDS FROM AN EGYPTIAN
LEPTOLYNGBYA SP.STRAIN
Authors
Nermin Adel El Semary
Helwan, Egypt 11795
Affiliation
Abstract
An investigation into the bioactive metabolites from a benthic, mat-forming strain dominating a
polluted wastewater canal in Egypt was conducted. Phytochemical screening revealed the presence of
saponins, flavonoids and alkaloids; vitamin C was also found at high concentrations. The isolate was
investigated as a source of antimicrobial compounds. The lipophilic fraction was extracted using
chloroform/methanol and bioassays for antimicrobial compounds were performed using strains of
pathogenic bacteria. The fraction that showed the highest bioactivity was purified and its structure
elucidated using UV, FTIR, proton-NMR and GC-MS. The compound's molecular weight was 220 and it
was identified as butylated hydroxytoluene which has both antimicrobial and antioxidant activities.
On the ecological front, this compound, and the other metabolites detected, seem to enable the isolate
to dominate its niche and protect it from adverse conditions. On the commercial front, this compound
is used as a food additive and was recently discovered in different cyanobacteria, and can be used as a
lead compound for both drug and food industries to substitute for the expensive and hazardous
synthetic analogs. Therefore, this strain can be considered as a potential source of bioactive
compounds that should be further explored.
Key words
Phytochemical screening- UV, FTIR, Proton-NMR, GC-MS, Butylated hydroxytoluene.
2011
Journal
I.F =1.988
Research
Title
Authors
Affiliation
Faculty of Science
Molecules 2011,16,52-73; doi: 10.3390/moleculesI6010052
NOVEL SYNTHESIS AND ANTITUMOR EVALUATION OF POLYUNCTIONALLY
SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 2-CYANO-N(3-CYANO -4,5,6,7-TETRAHYDROBENZO (b)THIOPHEN-2yl) - ACETAMIDE
Hoda Z. Shams 1, Rafat M. Mohareb 2,3,* , Maher H. Helal 1 and Amira E. Mahmoud I
1Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo,
Egypt
2 Department of Organic Chemistry, Faculty of Pharmacy, October University for
Modern Sciences
and Arts, October City, Egypt
3 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
* Author to whom correspondence should be addressed; E-Mail:
[email protected];
Tel.: +202-37626269 or +202-35676570.
Abstract
The reaction of 2-amino-3-cyano-4,5,6, 7-tetrahydrobenzo[b]thiophene with ethyl cyanoacetate gave
2-cyano-N-(3-cyano-4,5,6, 7-tetrahydrobenzo[ b]thiophen-2-y I)-acetamide. The latter was used to
synthesize different heterocyclic derivatives comprising thiophene, thiazole, pyrazole, pyridine,
pyrimidine, and coumarin rings. The mechanistic and synthetic pathways depended on regioselective
attack and/or cyclization by the cyanoacetamido moiety in the key precursor on various chemical
reagents. The competition of the reaction pathways including dipolar cyclization, dinucleophilicbielectrophilic attack, ~-attack, Gewald-type attack, and condensation reactions led to the diversity of
the synthesized products. The antitumor activities of the synthesized products were studied and
evaluated. Most of the compounds revealed high inhibitory effects when screened in vitro for their
antiproliferative activity. Three human cancer cell lines, namely, breast adenocarcinoma (MCF-7),
non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were used in the screening tests. The
simplicity of the synthetic procedures which mainly involved one-pot reactions under mild reaction
conditions, the convenience of yield production and the diversity of the reactive sites in the produced
systems play a valuable role for further heterocyclic transformations and further biological
investigations.
Key words
4,5,6,7 –tetrahydrobenzo [ b] thiophene; thiazole; pyrazole; pyridine; antitumor
2011
Faculty of Science
Journal
I.F =4.520
The JOURNAL OF PHYSICAL CHEMISTRY C J. Phys. Chem. C, 2011, 115 (24), pp
12163–12172
Research
Title
GROWTH AND REACTIVITY OF SILVER NANOPARTLCLES ON THE SURFACE OF
TIO₂ A STOPPED-FLOW STUDY
Authors
Affiliation
a
a
Hanan H. Mohamed , b Ralf Dillert , and b Detlef W. Bahnemann
Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt
Institut für Technische Chemie, Leibniz Universität Hannover, Callinstrasse 3, D30167, Hannover, Germany
b
Abstract:
The reaction of electrons stored on TiO2 nanoparticles with silver ions in aqueous solution has been
studied employing the stopped flow technique. Prior to the kinetic experiments, nanosized TiO2
particles were loaded with electrons by UV (A) photolysis in the presence of methanol. The
formation of silver nanoparticles is detected by their typical surface plasmon (SP) absorbance band
at 400 nm. Multiphase kinetic decay curves were observed for the electron absorbance as well as for
the build-up of the plasmonic absorbance of the silver nanoparticles. This kinetic behavior is
attributed to the multistep formation mechanism of the silver particles on the surface of TiO2
followed by the transfer of excess electrons to the deposited silver particles. The mechanism of the
formation and growth of the silver particles on the TiO2 surface is proposed to be as following: (i)
reduction of silver ions to form silver atoms which in turn form the nuclei for the metal particles, (ii)
growth of the silver nuclei to form silver particles, and (iii) coalescence of the formed silver particles
to form even bigger particles. Following the reduction of all silver ions present in solution, the
remaining excess electrons are then transferred to the deposited silver particles resulting in a slight
blue shift of the surface plasmon band. Subsequently, the stored electrons on the silver particles are
used for the reduction of adsorbed H+ to produce H2 gas. The effect of Polyvinyl alcohol (PVA) as a
stabilizer for the deposited metal nanoparticles as well as the effect of molecular oxygen on the
unstabilized silver deposits have also been investigated. It could be shown that molecular oxygen
acts as an electron acceptor, resulting in the partial oxidation of the deposited silver particles and
thus a red shift and a damping of the surface plasmon absorbance band. The rate constants of the
decay of the TiO2 electron absorbance as well as of the build-up of the plasmon absorbance of the
silver nanoparticles have been measured.
2011
Journal
I.F =2.732
Research
Title
Authors
Affiliation
Faculty of Science
The JOURNAL OF PHYSICAL CHEMISTRY A
KINETIC AND MECHANISTIC INVESTIGATIONS OF MULTIELECTRON TRANSFER
REACTIONS INDUCED BY STORED ELECTRONS IN TIO₂ NANOPARTICLES:A
STOPPED FLOW STUDY
a Hanan H. Mohamed, b Cecilia B. Mendive, b Ralf Dillert, and c Detlef W. Bahnemann
a Chemistry Department, Faculty of Science, Helwan University, Ain Helwan, Cairo,
Egypt
b Institut für Technische Chemie, Leibniz Universität Hannover, Callinstrasse 3, D30167 Hannover, Germany
c Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad
Nacional de Mar del Plata, Dean Funes 3350, 7600 Mar del Plata, Argentina
Abstract:
The kinetics and the mechanism of various multielectron transfer reactions initiated by stored
electrons in TiO2 nanoparticles have been investigated employing the stopped flow technique.
Moreover, the optical properties of the stored electrons in the TiO2 nanoparticles have been studied
in detail following the UV (A) photolysis of deaerated aqueous suspensions of TiO 2 nanoparticles in
the presence of methanol. The reduction of common electron acceptors that are often present in
photocatalytic systems such as O2, H2O2, and NO3− has been investigated. The experimental results
clearly show that the stored electrons reduce O2 and H2O2 to water by multielectron transfer
processes. Moreover, NO3− is reduced via the transfer of eight electrons evincing the formation of
ammonia. On the other hand, the reduction of toxic metal ions, such as Cu(II), has been studied
mixing their respective anoxic aqueous solutions with those containing the electrons stored in the
TiO2 particles. A two-electron transfer is found to occur, indicating the reduction of the copper metal
ion into its non toxic metallic form. Other metal ions, such as Zn(II) and Mn(II), could not be reduced
by TiO2 electrons, which is readily explained on the bases of their respective redox potentials. The
underlying reaction mechanisms are discussed in detail.
2011
Faculty of Science
Journal
I.F =2.243
Journal of Photochemistry and Photobiology A: Chemistry 217 (2011) 271-274
Research
Title
REACTION DYNAMICS OF THE TRANSFER OF STORED ELECTRONS ON TIO₂
NANOPARICLES A STOPPED FLOW STUDY
Authors
Mohamed Hanan H., b Dillert Ralf, and b Bahnemann Detlef W.
a Chemistry Department, Faculty of Science, Helwan University, Ain Helwan, Cairo,
Egypt
b Institut für Technische Chemie, Leibniz Universität Hannover, Callinstrasse 3, D30167 Hannover, Germany
Affiliation
a
Abstract
The dynamics of the transfer of electrons from TiO2 nanoparticles to a variety of electron acceptors
have been investigated employing a simple and facile stopped flow technique. Prior to the kinetic
experiments nanosized Ti02 particles are loaded with electrons by UV (A) photolysis in the presence
of methanol as a hole scavenger. As a model for possible electron transfer reactions the reduction of
dissolved 02 and H2O2 by stored TiO2 electrons has been successfully studied.
Key words
Reaction Dynamic, Electron transfer, TiO2 nanoparticles, stopped flow
2011
Faculty of Science
Journal
I.F =2.054
Journal of Hazardous Materials 186 (2011) 1527-1540
journal homepage: www:elsevier.comllocate/jhazmat
Research
Title
EFFECT OF SOME CEMENT COMPONENTS ON ION CONTENTS IN DIFFERENT
BRAIN AREAS OF ADULT MALE ALBINO MICE
Authors
Abd el-Rahman M, el-Khadragy MF, Abd-el Hay H, Gab-Allah DM.
Affiliation
Zoology Department, Faculty of Science, Helwan University, Cairo, Egypt.
Abstract
The aim of this study is to investigate the chronic effect of some cement components on the content of
ions in different brain areas in adult male albino mice. It is clear that chronic intraperitoneal
administration of 0.0013 mg/g aluminum ion caused a significant increase in aluminum. calcium and
sodium ions and significant decrease in iron ions the chronic intraperitoneal administration of
0.00065 mg/g iron caused a significant increase in iron calcium and sodium ions but No significant
change in potassium and aluminum ions. Chronic intraperitoneal administration of 0.0013 mg/g
silicon caused no significant change in calcium potassium sodium aluminum and iron. Chronic
intraperitoneal administration of 0.0013 rngjg aluminum. 0.0013 ttvglg silicon and 0.00065 mg/g
iron respectively using separating time interval 30 min between each - caused a higher elevation in
calcium sodium aluminum and iron concentrations than the elevation in other groups and no
significant change in potassium ions. This may be due to the elevation in glutamate which leads to
increase in the intracellular of calcium concentration and the inhibition of membrane-bound Na", K+.
Ca2+ ATPase activity which lead to cellular alterations and may be death. So long-term exposure to
cement components as environmental pollutants may lead to neurodegenerative diseases.
Key words
Aluminum Silicon Iron Cement Brain Ion contents
2011
Journal
I.F =1.988
Research
Title
Authors
Affiliation
Faculty of Science
Molecules 2011, 16,6271-6305; doi: 10.3390/moleculesl 6086271
DESIGN AND SYNTHESIS OF NOVEL ANTIMICOBIL ACYCLIC AND HETEROCYCLIC
DYES AND THEIR PRECURSORS FOR DYEING AND/OR TEXtile finishing based on
2-N-ACYLAMINO-4,5,6,7-TETRAHYDROBENZO
b)THIOPHENE SYSTEMF
1
Hoda Zaki Shams , Rafat Milad Mohareb 2,3,*, Maher Helmy Helal 1 and
Amira EI-Sayed Mahmoud 1
1 Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo,
P.O. 11790, Egypt
2 Department of Organic Chemistry, Faculty of Pharmacy, October University for
Modern Sciences and Arts, October City, P.O. 12613, Egypt
3 Department of Chemistry, Faculty of Science, Cairo University, Giza, P.O. 12311,
Egypt
[email protected];
Tel.: +202-37626269 or +202-35676570.
Abstract
A series of novel polyfunctionalized acyclic and heterocyclic dye precursors and their respective azo
(hydrazone) counterpart dyes and dye precursors based on conjugate enaminones and/or
enaminonitrile moieties were synthesized. The dyes and their precursors are based on 2-cyano-N-(3cyano-4,5,6, 7-tetrahydrobenzo[b ]thiophen-2-yl)-acetamide, 2-ethoxycarbony I-N-(3-cyano-4,5,6, 7tetrahydrobenzo[b]thiophen-2-y I)-acetamide or 2-pheny Icarbamoy I-N-(3-cyano-4,5,6, 7tetrahydrobenzo[ b]thiophen-2-y I)-acetamide systems as precursors. The latter compounds were
used to synthesize poly functional thiophene-, thiazole-, pyrazole, pyridine-, pyrimidine-, oxazine-, as
well as acyclic moieties. The dyes and dye precursors were characterized by elemental analysis and
spectral methods. All dyes and their precursors were screened in vitro and evaluated for both their
antibacterial and antifungal activities. MIC data of the novel dye systems and their respective
precursors showed significant antimicrobial activity against most tested organisms. Some
compounds exhibited comparable or even higher efficiency than selected standards. Dyes were
applied at 5% depth for disperse dyeing of nylon, acetate and polyester fabrics. Their spectral
characteristics and fastness properties were measured and evaluated.
Key words
heterocyclic; dyes; antimicrobial activity; textile finish; fastness
2011
Journal
I.F =1.771
Research
Title
Authors
Affiliation
Faculty of Science
Sensors 2011, 11, 1-x manuscripts; doi:10.3390/s110xOOOOx
WEARABLE AND IMPLANTABLE WIRELESS SENSOR NETWORK SOLUTIONS EOR
HEALTHCARE MONITORING
AshrafDarwish1,* and Aboul Ella Hassanieu2
1 Faculty of Science, Helwan University, Cairo, Egypt
2 Faculty of Computers and Information, Cairo University, Cairo, Egypt
E-Mails:[email protected];[email protected]
* Corresponding author. Tel.: +20105645222; fax: +20225552468
Abstract
Wireless sensor network technologies are considered as one of the key research areas in computer
science and healthcare application industries can be used for improving the quality of life. The
purpose of this paper is to give a snapshot on current development and future direction of evolution
in wearable and implantable body area network system for continuous monitoring for patients
elsewhere. However, this paper explains the important role of body sensor networks in medicine
which minimize the need for caregivers and help the chronically ill and elderly people to survive an
independent life, besides provides quality care for people. The paper provides several state of the art
examples together with the design considerations like unobtrusiveness, scalability, energy efficiency,
security and also provides a comprehensive analysis of the benefits and drawbacks of these systems.
Although having significant benefits, the area of wearable and implantable body sensor network has
still major challenges and open research problems which are investigated and covered with proposed
solutions in this paper.
Key words
Wireless sensor networks, body area networks, wearable sensors, implantable
sensors, healthcare applications, biosensors, nanotechnology, privacy, security
2010
Journal
I.F =9.855
Research
Title
Authors
Affiliation
Faculty of Science
ACS Nano VOl. 4, NO.6, 3039-3044, 2010
AN OPTICAL NANOCAVITY INVORPORATING A FLUORESCENT ORGANIC DYE
HAVING A HIGH QUALITY FACTOR
t
Ali M.Adaw ·* Mohamed M. Mursidyt.·§ PaulW. Fry,± and David G. Lidzeyt·*
department of Physics and Astronomy,The University of Sheffield, Hicks Building,
HounsfieldRoad,Sheffield53 7RH,United Kingdom,
±Nanoscience and Technology Centre, University of
Sheffield,NorthCampus,BroadLane,Sheffield,53 7HQ,UnitedKingdom, and
§Department of Physics ,Faculty of Science ,Helwan University, Helwan, Egypt
Abstract
We have fabricated an l3 optical nanocavity operating at visible wavelengths that is coated with a
thin-film of a fluorescent molecular-dye. The cavity was directly fabricated into a pre-etched, freestanding silicon-nitride (SiN) membrane and had a quality factor of Q = 2650. TIls relatively high Qfactor approaches the, theoretical limit that can be expected from an L3 nanocavity using silicon
nitride asa dielectric material and is achieved as a result of the solvent-free cavity-fabrication
protocol that we have developed .We show that the fluorescence from a red-emitting fluorescent dye
coated onto the cavity surface undergoes strong emission intensity enhancement at a seriesof
discrete wavelengths corresponding to the cavity modes .Three dimensional finite difference time
domain (FDTD) calculations are used to predict the mode structure of the cavities with excellent
agreement demonstrated between theory and experiment.
Key words
Optical nanocavity, photonic crystal, organic-semiconductor, fluorescent moleculardye, finite difference time domain calculations
2010
Faculty of Science
Journal
I.F =2.095
Vol. 27, No 21, February 2010/J. Opt. Soc. Am. B
Research
Title
THE OPTICAL PROPERTIES OF HYBRID ORGANIC-INORGANIC L3 NANOCAVITIES
Authors
Affiliation
Mohamed M. Murshidy,1,3 Ali M. Adawi,l·4 Paul W. Fry,2 David M. Whittaker,1 and
David G. Lidzey1,5
1Deportment of Physics and Astronomy, The University of Sheffield, Hicks Building,
Hounsfield Road,
Sheffield S3 7RH, United Kingdom
2Nanoscience and Technology Centre, University of Sheffield, North Campus, Broad
Lane,
Sheffield, S3 7HQ, United Kingdom
3Department of Physics, Faculty of Science, Helwan University, Helwan Egypt
4Email: [email protected]
5Email: [email protected]
Abstract
We report the fabrication of L3 nanocavities defined into a free-standing silicon nitride (SiN)
membrane coated with a thin (10 nm) film of fluorescent red-emitting conjugated polymer. We find
that structures both with and without the conjugated polymers are characterized by a number of
different confined optical modes with quality factors ranging between 450 and 1200. We characterize
the polarization of the modes and discuss the enhancement of emission intensity from both the SiN
and the polymer using spectral imaging.
2010
Journal
I.F =3.820
Research
Title
Authors
Affiliation
Faculty of Science
APPLIED PHYSICS LEITERS 97, 153303 (2010)
A ONE DIMENSIONAL PHOTONIC CRYSTAL NANOCAVITY INCORPORATING
FLUORESCENT MOLECULAR DYE
Mohamed M. Murshidy,1,2 AIi M. Adawi,1.3,a Paul W. Fry,4 and David G. Lidzeyl,b
IDepartment of Physics and Astronomy, The University of Sheffield. Hicks Building,
Hounsfield Road, Sheffield S3 7RH, United Kingdom
2Department of Physics, Faculty of Science, Helwan University, P'O.B. 11795, Helwan,
Egypt
3Departmenl of Physics, University of Hull, Cottingham Road, Hull HU6 7RX, United
Kingdom
4Nanoscience and Technology Centre, University of Sheffield, North Campus, Broad
Lane, Sheffield, S3 7HQ, United Kingdom
Abstract
We model the optical properties of a SiN based one-dimensional waveguide photonje crystal
nanocavity with three tapered air holes as a function of the photonic crystal mirror fill factor using
finite difference time domain calculations. We show that the Q-factor of this type of cavity has a
strong dependence on the mirror fill factor, with a Q-factor as high as 35000 predicted. Experimental
studies on a range of representative structures whose surface is coated with a layer of a fluorescent
dye con film our modeling and reveal that such structures are characterized by a single optical mode
having a Q-factor of 2000.
2011
Faculty of Science
Journal
I.F =2.054
International Journal of Geometric Methods in Modern Physics
Volume 08, Issue 01, February 2011
Research
Title
Authors
Affiliation
ON THE SOLUTION SETS OF FOUR-POINT BOUNDARY VALUE PROBLEMS FOR
NONCONVEX DIFFERENTIAL INCLUSIONS
Adel Mahmoud Gomaa
Mathematics Department, Faculty of Science, Helwan University, Cairo, Egypt
Abstract:
We consider the multivalued problem
under four boundary conditions u(0) =
x0, u(η) = u(θ) = u(T) where 0 < η < θ < T and for F is a multifunctions from [0, T] × ℝn × ℝn to the
nonempty compact subsets of ℝn not necessary convex. We give a lemma which is useful in the study
of four boundary problems for the differential equations and the differential inclusions. Further we
have results that improve earlier theorems.
Key words
Differential inclusions, four-point boundary value problems, solution sets, Creen
functions, Second derivatives.
2010
Journal
I.F =0.757
Research
Title
Authors
Affiliation
Faculty of Science
International Journal of Geometric Methods in Modern Physics
Volume 07, Issue 03, May 2010
ON BOUNDED WEAK A D PSEUDO-SOLUTIONS OF NO LI EAR DIFFERENTIAL
EQUATIONS HAVING TRICHOTOMY WITH AND WITHOUT DELAY IN BA ACH
SPACES
Adel Mahmoud Gomaa
Mathematics Department, Faculty of Science, Helwan University, Cairo, Egypt
Abstract
In the present work we consider E is a Banach space, E* is its dual space and L(E) is the space of
continuous linear operators from E to itself. A function x: ℝ → E is said to be a pseudo-solution of the
equation
where A:ℝ → L(E) is strongly measurable and Bochner
integrable function on every finite subinterval of ℝ with f:ℝ × E → E is only assumed to be weakly
weakly sequentially continuous or Pettis-integrable and the linear equation
has a
trichotomy with constants α ≥ 1 and σ > 0, if x is absolutely continuous function and for each x* ∈ E*
there exists a negligible set ℵx* such that for each t ∉ ℵx*, then we have
We give an existence theorem for bounded weak and pseudosolutions of the nonlinear differential equations
Let T, r, d > 0, Br = {x
> E: ‖ x‖ ≤ r} and CE([-d,0]) be the Banach space of continuous functions from [-d,0] into E. Finally we
prove
an
existence
result
for
the
differential
equation
with
delay
where fd : [a,b] × CE([-d,0]) → E is weakly weakly sequentially
continuous function,
is strongly measurable and Bochner integrable operator on
[a,b] and θtx(s) = x(t + s) for all s ∈ [-d,0].
Key words
Nonlinear differential equations; weak solutions; pseudo-solutions; trichotomy; delay
2010
Journal
I.F =1.770
Research
Title
Authors
Affiliation
Faculty of Science
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume 91, June 2012, Pages 11–17
PREPARATION, SPECTROSCOPIC AND THERMAL CHARACTERIZATION OF NEW
METAL COMPLEXES OF VERLIPRIDE DRUG. IN VITRO BIOLOGICAL ACTIVITY
STUDIES
M.H. Soliman a, Gehad C Mohamed b
a Chemistry Department, Faculty of Science, Helwan University, Helwan, Egypt
b Chemistry Department. Faculty of Science, Cairo University, 12613 Giza, Egypt
Abstract:
Metal complexes of the general formula [M(VER)2Cl2(H2O)2]·yH2O and [Cr(VER)2Cl2(H2O)2]Cl·H2O
(where VER = verlipride, M = Mn(II) (y = 2), Co(II) (y = 2), Ni(II) (y = 2), Cu(II) (y = 1) and Zn(II)
(y = 0)) are prepared and characterized based on elemental analyses, IR, 1H NMR, magnetic moment,
molar conductance, and thermal analyses (TG and DTA) techniques. From the elemental analyses
data, the complexes are formed in 1:2 [Metal]:[VER] ratio. The molar conductance data reveal that all
the metal chelates are non-electrolytes except Cr(III) complex, it is 1:1 electrolyte. IR spectra show
that VER is coordinated to the metal ions in a neutral monodentate manner with O donor site of the
carbonyl O atom. On the basis of spectral studies and magnetic moment measurements an octahedral
geometry has been assigned for the complexes. The thermal behavior of these chelates is studied
using thermogravimetric analysis technique. The results obtained show that the complexes lose
hydrated water, HCl and coordinated water molecules followed immediately by decomposition of the
ligand molecules in the successive unseparate steps. The VER drug, in comparison to its metal
complexes is also screened for its biological activity against Gram positive bacterial (Staphylococcus
aureus) and Gram negative bacteria (Escherichia coli) and fungi (Candida albicans and Aspergillus
flavus) in vitro. The activity data show that most of the metal complexes have antibacterial activity
like or higher than that of the parent VER drug against one or more species.
Key words
Verlipride Meral complexes IR Molar conductance Magnetic moment H NMR
Thermal analyses Biological activity
2010
Faculty of Science
Journal
I.F =2.054
Z Naturforsch C. 2010 Sep-Oct; 65(9-10):577-87.
Research
Title
A NEW CLASS OF ANTIMETABLITES PYIDINE THIOGLYCOSIDESAS POTENTIAL
ANTICACER AGENTS
Authors
Elgemeie GH, Mahdy EM, Elgawish MA, Ahmed MM, Shousha WG, Eldin ME.
Faculty of Science, Chemistry Department, Helwan University, Helwan, Cairo, Egypt.
[email protected]
Affiliation
Abstract:
The present study was designed for highlighting and focusing on the cytotoxic activity of a new class
of antimetabolites both on human cell lines, namely liver carcinoma cell line (Hepg2), lung carcinoma
cell line (H460), breast carcinoma cell line (MCF7), brain carcinoma cell line (U251), and animal cell
line EAC (Ehrlich ascites carcinoma cells). The results revealed that some of these modified
deazapyrimidine thioglycosides have significant cytotoxic activity against EAC cells with growth
inhibition percentage ranged between 80% to 90%. The possible inhibitory mechanism of the
pyridine thioglycosides was explored by studying the cell cycle perturbation of thioglycosides against
human cell lines (in vitro) as well as the most suitable time for maximum compound cytotoxic activity
after 6, 18, and 24 h of incubation. To confirm the cytotoxic activity of these compounds, they have
been tested for their apoptotic and antiproliferative activity in vivo against solid Ehrlich tumours
using five groups of Swiss albino mice for 37 days from inoculation and three treatments, 250, 500
and 1000 microg/kg body weight. There was significant reduction in Ehrlich tumour size in case of
the 500 and 1000 microg/kg body weight group but mild significant tumour reduction in the 250
microg/kg body weight group. Histograms of DNA per cell for each treatment group indicated that
there was a dose-dependent increase in the preG1 phase with a corresponding complete arrest of
cells from entering the G2/M phase compared to the untreated EAC group. In conclusion, pyridine
thioglycosides have proven good cytotoxic effects against EAC cells and also significant cytotoxic
activity against the four tested human cell lines. Flow cytometric DNA ploidy analysis of pyridine
thioglcyosides against the Hepg2 and U251 cell lines revealed that the postulated mechanism of
action of pyridine thioglcyosides is cell cycle arrest in the S phase. This is similar to antimetabolites
and cell cycle arrest in the G2/M phase (M phase) in the same way as microtubule inhibitors like
pyridine thioglycosides are cell-cycle-specific in the S phase and the M phase (in case of human cell
lines) and have apoptotic effects (in case of animal cell line).
Key words
Anticancer agents, antimetabolities, Pyridine Thioglycosides
2011
Faculty of Science
Journal
I.F =2.410
Journal of Gastroenterology and Hepatology
Volume 26, Issue 5, pages 843–850, May 2010
Research
Title
SINGLE NUCLEOTIDE POLYMERPBTSM AT EXON 7 SPLIC ACCEPTOR SITE OF
OAS1 GENE DETER MINES RESPONSE OF HEPATITS C VIRUS PATIENTS TO
INTERAPY
Authors
Affiliation
Mostafa K El Awady,* Mohamed A Anany,* Gamal Esmat,† Naglaa Zayed,† Ashraf A
Tabll,*
Amr Helmy,‡ Abdel Rahman El Zayady,• Mohga S Abdalla, Hayat M Sharada, Maissa El
Raziky,†Wafaa El Akel,† Shadia Abdalla** and Noha G Bader El Din*
*Department of Microbial Biotechnology, National Research Center, and †Department
of Tropical Medicine Gastroenterology and Liver Diseases, Kasr El Aini, and §Cairo
Liver Center, and **Department of Clinical Pathology, El Sahel Teaching Hospital, Cairo,
and ‡National Liver Institute, Shebeen El Kom, EL Monufea, and ¶Faculty of Sciences
Helwan University, Helwan, Egypt
Abstract:
Background and Aim: Response to interferon therapy and disease progression in hepatitis C virus
(HCV) infected patients differs among individuals, suggesting a possibility of a contribution of host
genetic factors. 2′-5′-oligoadenylate synthetase 1 (OAS1), an important component of the innate
immune system with a proven antiviral function, may therefore have a relationship with the response
to interferon therapy and clinical course of HCV disease. Our aim was to determine the frequency of
single nucleotide polymorphism (SNP) at exon 7 splice acceptor site (SAS) of the OAS1 gene in
relation to the interferon response and status of HCV infection.
Methods: A 203 bp fragment containing exon 7 SAS was amplified in 70 HCV chronic patients and 50
healthy controls. SNP was examined using restriction fragment length polymorphism (RFLP)
genotyping method. Correlations of SNP genotypes with response to interferon and clinical status of
patients were statistically analyzed.
Results: There was an increasing trend of response from AA to AG to GG genotypes (P = 0.007).
Genotype AA was associated with non-response to interferon and higher degree of liver fibrosis
(P = 0.05). Multivariate analysis showed this SNP as independent and a significant determinant of the
outcome of interferon therapy (odds ratio 4.913 [95% confidence interval 1.365–8.2], P = 0.006).
Conclusions: This is the first study to show a significant association between the functional SNP at
exon 7 SAS of OAS1 gene and the viral response to interferon in chronic HCV patients. Patients with
AA genotype were associated with progressive HCV disease and viral resistance to interferon
therapy. This OAS SNP is a potential bio-marker to predict IFN response in chronic hepatitis C
patients.
Key words
Hepatitis C virus; iver fibrosis; OAS1; response to interferon therapy; single nucleotide
polymorphism
2011
Journal
I.F =4.538
Research
Title
Authors
Faculty of Science
J Nutr Biochem. 2012 Jan;23(1):39-50. Epub 2011 Mar 16.
ACUTE AND CHTONIC SATURATED FATTY ACID TREATMENT AS A KEY
INSTIGATOR OF THE TLR-MEDIATED INFAMMATORY RESPONSE IN HUMAN
ADIPOSE TISSUE,IN VITRO
a
Elham M. Youssef-Elabd, Kirsty C. McGee,b Gyanendra Tripathi,b Nasser Aldaghri,f
Mohga S. Abdalla,c Hayat M. Sharada,c Esmat Ashour,a Ashraf I. Amin,d Antonio
Ceriello,e Joseph P. O'Hare,b Sudhesh Kumar,b Philip G. McTernan,b and Alison L.
Harteb,
aBiochemistry
Department, National Research Centre, Dokki, Giza, Egypt 12622
of Warwick, Unit for Diabetes and Metabolism, Warwick Medical School, Clinical
Sciences Research Institute, UHCW, Coventry, UK CV2 2DX
cChemistry Department, Faculty of Science, Helwan University, Egypt 11795
dClinical Pathology Department, National Institute of Diabetes and Endocrinology, Cairo,
Egypt 11562
eInsititut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Calle Mallorca 183, Piso
P01, 08036 Barcelona, Spain
fKing Saud University, College of Science Biochemistry Department, Riyadh 11451, Saudi
Arabia
Alison L. Harte: [email protected]
Corresponding author. Tel.: +44 24 76968645; fax: +44 24 76968653 ; Email:
[email protected]
bUniversity
Affiliation
Abstract
A post-prandial increase in saturated fatty acids (SFAs) and glucose (Glc) activates an inflammatory
response, which may be prolonged following restoration of physiological SFAs and Glc levels--a
finding referred to as 'metabolic memory'. This study examined chronic and oscillating SFAs and Glc
on the inflammatory signalling pathway in human adipose tissue (AT) and adipocytes (Ads) and
determined whether Ads are subject to "metabolic memory." Abdominal (Abd) subcutaneous (Sc)
explants and Ads were treated with chronic low glucose (L-Glc): 5.6 mM and high glucose (H-Glc):
17.5 mM, with low (0.2 mM) and high (2 mM) SFA for 48 h. Abd Sc explants and Ads were also
exposed to the aforementioned treatment regimen for 12-h periods, with alternating rest periods of
12 h in L-Glc. Chronic treatment with L-Glc and high SFAs, H-Glc and high SFAs up-regulated key
factors of the nuclear factor-κB (NFκB) pathway in Abd Sc AT and Ads (TLR4, NFκB; P<.05), whilst
down-regulating MyD88. Oscillating Glc and SFA concentrations increased TLR4, NFκB, IKKβ (P<.05)
in explants and Ads and up-regulated MyD88 expression (P<.05). Both tumor necrosis factor α and
interleukin 6 (P<.05) secretion were markedly increased in chronically treated Abd Sc explants and
Ads whilst, with oscillating treatments, a sustained inflammatory effect was noted in absence of
treatment. Therefore, SFAs may act as key instigators of the inflammatory response in human AT via
NFκB activation, which suggests that short-term exposure of cells to uncontrolled levels of SFAs and
Glc leads to a longer-term inflammatory insult within the Ad, which may have important implications
for patients with obesity and Type 2 diabetes.
2010
Faculty of Pharmacy
Journal
I.F =3.193
European Journal of Medicinal Chemistry 45 (2010) 1267-1277
journal homepage: http://www.elsevier.com/Iocate/ejmech
Research
Title
SYNTHESIS AND ANTI-INFLAMMATORY EVALUATION OF SOME CONDENSED (4(3,4- DIMETHYPHENY1) -1(2H)-OXO-PHTHALZIN -2-Y1)ACID HYDRAZIDE
Mosaad S.M. Abd alia a, Mohamed I. Hegab b." Nageh A. Abo Taleb a, Sherifa M.
Hasabelnaby a, A. Goudah C
a Pharmaceutical organic chemistry Department, Faculty of Pharmacy, Helwan
University, Ain Helwan, Cairo, Egypt
b Photochemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt
C Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza,
Egypt
Authors
Affiliation
Abstract
Some new 1.3.4-triazolo-. 1.3.4-oxadiazolo-. 1.3.4-thiadiazol and pyrazoI0-3.4-dimethylphenyl-l (2H)oxo-phthalazine derivatives were synthesized and identified by IR.1H NMR.MS and elemental
analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities.
Among them Compounds 11.17b. 20. 21 and 22 are active compare to the activity of indomerhacin.
Key words
1(2H)-Oxo-phthalazine 1.3,4-Triazole 1.3,4-0xadiazole 1.34-Thiadiazol Pyrazole
Anri-inflarnmatory
2010
Journal
I.F =2.737
Research
Title
Authors
Affiliation
Faculty of Pharmacy
European Journal of Pharmacology
journal homepage: www.elsevier.com/l ocate/ejphar
TRANSCRIPT PROFILING IDENTIFIES NOVEL KEY PLAYERS MEDIATING THE
GROWTH INHIBITORY EFFECT OF NS-398 ON HUMAN PANCREATIC CANCER
CELLS
a.b,c
Mahmoud Youns .*, Thomas Efferth b, jorg D. Hoheisel a
a Functional Genome Analysis, German Cancer Research Centre (DKFZ), Im
Neuenheimer Feld 580, 69120 Heidelberg, Germany
b Department of Pharmaceutical Biology, institute of Pharmacy and Biochemistry,
University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany
C Department of Biochemistry, Faculty of Pharmacy, University of Helwan, Ain
Helwan, 11795Cairo,Egypt
Abstract
Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence
worldwide. Despite an increase in the number of systemic treatments available for pancreatic cancer.
the impact of therapy on the clinical course of the disease has been modest. underscoring an urgent
need for new therapeutic options. Although selective cyclooxygenase-2 inhibitors have been
demonstrated to have cancerpreventive effects. the mechanism of their effects is not clearly known.
Moreover, there have been no unbiased studies to identify novel molecular targets of NS-398
regarding pancreatic cancer. Here we undertook a gene expression profiling study to identify novel
molecular targets modulating the growth inhibitory effects ofNS-398 on pancreatic cancer cell lines.
Our mRNA-based gene expression results showed that the growth inhibitory effect of NS-398 was
accompanied with an activation of Gl/S and G2/M cell cycle regulation. PS3 signalling. apoptotic, aryl
hydrocarbon receptor and death receptor signalling pathways. Moreover. we reported. for the first
time. that the growth inhibitory effect of NS-398 is mediated by down regulation of RRM2. CfGF.
MCM2 and PCNA and up-regulation of NAG-l in all cell lines.
Key words
Pancreatic cancer Microarray Ingenuity NS-398
2010
Faculty of Pharmacy
Journal
I.F =8.234
Cancer Research
Research
Title
EPIGENETICALLY DEREGULATED MICRO RNA-375 IS INVOLVED IN A POSITIVE
FEEDBACK LOOP WITH ESTROGEN RECEPTOR A IN BREAST CANCER CELLS
Authors
Affiliation
Pedro de Souza Rocha Simonini1,2, Achim Breiling3, Nibedita Gupta4, Mahdi
Malekpour6, Mahmoud Youns 1.9, Ramesh Ornranlpour6, Fatemeh Malekpour7,
Stefano Volinia 10, Carlo M. Croce 11, Hossein Najmabadi8, Sven Dledertchs2, OzgOr
Sahln5, Doris Mayer4, Frank Lyko3, Jorg D. Hoheisel1, and Yasser Blazalhosselni1
1Division of Functional Genome Analysis.
2Helmholtz-University- Young Investigator Group Molecular RNA Biology
and Cancer. German Cancer Research Center (DKFZ) & Institute of
Pathology. University of Heidelberg. 3Division of Epigenetics. DKFZ2MBH Alliance. +Hormones and Signal Transduction Group. and
5Division of Molecular Genome Analysis. German Cancer Research
Center (DKFZ). Heidelberg. Germany; BCancer Institute. Imam Khomeini
Hospital, Tehran University of Medical Sciences. 7Shohada Tajrish
Hospital. Shahid Beheshti University of Medical Sciences. and "Genetics
Research Oenter, University of Social Welfare and Rehabilitation, Tehran,
Iran; 9Department of Biochemistry and Molecular Biology. Faculty of
pharmacy, University of Helwan. Ain Helwan. Cairo. Egypt; morphology and
Embryology .Ur rs: Ferrara, ltaly ;and Department of J Molecular Virology.
Immunology and Medical Genetics, Comprehensive Cancer Center. The Ohio State
University, Columbus. Ohio
Abstract
Estrogen receptor a (ERa) upregulation causes abnormal cell proliferation in about two thirds of
breast cancers, yet understanding of the underlying mechanisms remains incomplete. Here, we show
that high expression of the microRNA miR-375 in ERa-positive breast cell lines is a key driver of their
proliferation. miR-375 overexpression was caused by loss of epigenetic marks including H3K9me2
and local DNA hypomethylation, dissociation of the transcriptional repressor CTCF from the miR-375
promoter, and interactions of ERa with regulatory regions of miR-375. Inhibiting miR-375 in ERapositive MCF-7 cells resulted in reduced ERa activation and cell proliferation. A combination of
expression profiling from tumor samples and miRNA target prediction identified RASD1 as a
potential miR-375 target. Mechanistic investigations revealed that miR-375 regulates RASD1 by
targeting the 3' untranslated region in RASD1 mRNA. Additionally, we found that RASD1 negatively
regulates ERa expression. Our findings define a forward feedback pathway in control of ERa
expression, highlighting new strategies to treat ERa-positive invasive breast tumors.
2010
Journal
I.F = 2.369
Research
Title
Authors
Affiliation
Faculty of Pharmacy
Planta Med 2010; 76: 1-7
BERBERINE INHIBITS CELL GROWOTH AND MEDIATES CASPASE-INDEPENDENT
CELL DEATH IN HUMAN PANCREATIC CANCER CELLS
lina Pinto-Garcia1, Thomas Efferth2, Amada Torres 1, Jorg D. Hoheisel1,
Mahmoud Youns,1,2.3
1 Department Functional Genome Analysis, German cancer research center (DKF2)
Heidelberg, Germany
2 Department of Pharmaceutical Biology. Institute of Pharmacy and Biochemistry.
University of Mainz. Mainz. Germany
3 Department of Biochemistry. Faculty of Pharmacy, University of Helwan. Ain
Helwan. Cairo. Egypt
Abstract
Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence
worldwide. In addition to the poor survivalrates, combinations using gemcitabine as a backbone have
failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel
therapeutic options and motivated us to study the effect of berberine on pancreatic cancer cells. Here.
we undertook an mRNA-based gene expression profiling study in order to get deeper insight into the
molecular targets mediating the growth inhibitory effects of berberine on pancreatic cancer cells
compared to normal ones. Twenty-four hours after treatment, berberine showed preferential
selectivity toward pancreatic cancer cells compared to normal ones. Moreover, expression profiling
and Ingenuity pathway analysis results showed that the cytotoxicity of berberine was accompanied
with an activation of BRCAl-mediated DNA damage response, Gl/S and G2/M cell cycle checkpoint
regulation, and P53 signalling pathways. The activation of these signalling pathways might be
explained by the fact that berberine intercalates DNA and induces DNA strand break through
inhibition of topoisomerases and induction of DNA lesions.
Key words
Berberine pancreatic cancer microarray cell death photodynamic therapy
2010
Journal
I.F =1.918
Research
Title
Authors
Affiliation
Faculty of Pharmacy
journal of Pharmacy and Pharmacology
EFFECT OF THYMOQUINONE ON HEPATORENAL DYSFUNCTION AND
ALTERATION OF CYP3A1 AND SPERMIDINE/SPERMINE N-1ACETYTRANSFERASE GENE EXPRESSION INDUCED BY RENAL ISCHEAMIAREPERFUSION IN RATS
a
Azza S. Awad , Rehab karnel b and Mohie-Aldien Elsayed Sherief c
a Department of Pharmacology and Toxicology, Faculty of Pharmacy, AI-Azhar
University (Girls), Nasr City,
b Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan
University, Ein Helwan, Cairo
and c Department of Pharmacology, Faculty of Medicine, Benha University, Benha,
Egypt
Abstract
Objectives Renal ischemia-reperfusion (I/R) is a well-characterised model of acute renal failure that
causes both local and remote organ injury. The aim of this work was to investigate the effect of
thymoquinone, the main constituent of the volatile oil extracted from Nigella Saliva seeds, on renal
and hepatic changes after renal ischaemia-reperfusion. Methods Male Sprague-Dawley rats were
divided into sham I/R vehicle-treated groups, and IIR thyrnoquinone-treated groups. Thymoquinone
(10 mg/kg,p.o.) was administered for ten consecutive days to the IIR thymoquinone group before
injury. IfR and IIR thymoquinone groups were subjected to 30-min ischaemia followed by 4-h
reperfusion. Key findings I/R resulted in a significant increase in malondialdehyde (MDA) level and
decreases in glutathione-S-transferase (GST) and superoxide dismutasc (SOD) activity in liver and
kidney tissues. Thymoquinone treatment caused the reversal of lIR-induced changes in MDA as well
as GST and SOD activity. Moreover, fIR caused a significant rise in creatinine and alanine
aminotransferase serum levels. CYP3A I mRNA expression was induced significantly by IIR in both
liver and kidney tissues compared with sham group. Thymoquinone reduced significantly this
increase. l/R caused induction of mRNA expression of spermidine/spermine N-I-acetyl-transferase
(SSAT), a catabolic enzyme that participates in polyamine metabolism, in liver and kidney tissues.
Thymoquinone reduced SSAT mRNA expression significantly in liver and markedly in kidney.
Conclusions These findings suggested that thymoquinone protected against renal Induced damage
through an antioxidant mechanism as well as the decrease of CYP3A I and SSAT gene expression.
Key words
CYP3A I; oxidative stress; renal ischaernia-reperfusion; spermidine/spermine
N- J -acetyl-transferase; thymoquinone
2010
Journal
I.F =1.438
Research
Title
Authors
Affiliation
Faculty of Pharmacy
J BIOCHEM MOLECULAR TOXICOLOGY Volume 24, umber 2, 2010
EFFECT OF ROSUVASTATION ON CHOLESTSIS-INDUCED HEPATIC
INJURY IN RAT LIVERS
Azza S. Auiad1 and Rehab Kamel2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar
University (Girls), Nasr City, Cairo 11884, Egypt
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan
University, Ein Helwan, Cairo 11795, Egypt;
E-mail: [email protected]
Abstract
Recent studies reported that 3-hydroxy- 3-methyl-glutaryl coenzyme A (HMG-CoA) reductase
Inhibitors have pleotropic effects independent of their lipid-lowering properties. The present study
was undertaken to determine whether treatment with rosuvastatin (RO) would be beneficial in a rat
model of bile duct ligation (BOL). Animals were divided into three groups: a sham group (group I), a
BOL group treated with vehicle (group 11), and a BOL group treated with RO (10 mg/kg) (group Ill).
Serum levels of total bilirubin, Υ-glutamyl transpeptidase, alanine aminotransferase, and aspartate
aminotransferase decreased significantly in group III when compared to group n. Lipid peroxides and
NO levels of group In were found to be significantly lower than those of group n. Antioxidant enzymes
(superoxide dismutase, glutathione-S-transferase, and catalase) activity in liver tissues markedly
decreased in group 11,whereas treatment with RO preserved antioxidant enzyme activity. DTdiaphorase activity in group n was significantly higher than that in group Ill. The histopathological
results showed multiple numbers of newly formed bile ductules with inflammatory cells infiltration
in group n. These pathological changes were improved in group Hl. Our data indicate that RO
ameliorates hepatic injury, inflammation, lipid peroxidation and increases antioxidant enzymes
activity in rats subjected to BOL. RO may have a beneficial effect on treatment
of cholestatic liver diseases.
Key words
Biliary obstruction; Bile duct ligation; Cholestasis; Inflammation; Lipid peroxidation;
Oxidative stress; Rosuvastatin
2011
Journal
I.F =1.209
Research
Title
Authors
Affiliation
Faculty of Pharmacy
Immunopharmacology and Immunotoxicology, 2011; 33(1): 141-145
EVALUATION OF IMMUNOMODULATORY EFFECT OF THREE HERBAL PLANTS
GROWING IN EGYPT
Mohammed Ghonime1, Ramadan Eldomany1, Ahmed Abdelaziz2, and Hesham
Soliman3
1Department of Microbiology and Immunology, Helwan University, Helwan, Egypt,
2Departrnent of Microbiology and
Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt, and 3Department
of Pharmacognosy, Faculty of Pharmacy, Helwan University, Helwan, Egypt
Abstract
A group of medicinal plant including Silene (Silene nocturnal, Black seed (Nigella sativa) and
Chamomile (Matricaria chamomilla) growing in Egypt were examined for their immunomodulatory
effect in Balb/c mice. Treatment (intraperitoneal injection) with five doses of methanolic extract for
each plant was found to enhance the total white blood cells count (up to 1.2 x 1A· cells/mm'). Bone
marrow cellularity also increased significantly (P < 0.01) after the administration of the extract of
each of three test plants. Furthermore, spleen weight of the treated groups was significantly
increased (P < 0.01). Two groups of mice were immunosuppressed with cyclophosphamide, the one
which pretreated with the plants extracts significantly (P<O.01) restored their resistance against
lethal infection with the predominately granulocyte-dependant Candida albicans. These results
confirm the immunomodulatory activity of Silene, Black seed, and Chamomile extracts and may have
therapeutical implications in prophylactic treatment of opportunistic infections and as supportive
treatment in oncogenic cases.
Key words
Immunomodutatory; immunosuppressed mice; WBC count; Bone marrow cellularity;
Candida albicans
2010
Faculty of Pharmacy
Journal
I.F =3.193
European Journal of Medicinal Chemistry45 (2010) 2994-3004
Research
Title
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME THIO CONTAINING
PYRROLO (2,3-d) PYRIMIDINE DERIVATIVES FOR THEIR ANT-INFLAMMATORY
AND ANTI-MICROBIAL ACTIVITIES
Authors
Mosaad S. Mohamed a, Rehab Kamel b, Samar S. Fatahala a
a
Affiliation
Pharmaceutical Organic Chemistry Department, faculty of pharmacy. Helwan
University. He/wan. Egypt
b Toxicology and Pharmacology Department, faculty of pharmacy. Helwan
University. Helwan. Egypt
Abstract
The pyrroles la-c were used as precursor for the preparation of pyrrolo (2. 3-d) pyrimidine-2 and/or
4 thione derivatives lIa-f. A series of 8-Aryl-pyrrolo (2. 3-d) thiazolo(3,2-alpyrinudine VI and VII were
prepared. Alkylation of the thione compounds in basic medium afforded the pyrrolo 12. 3-d]
pyrimidine IV. Also some 2-amino pyrrolo (2. 3-d)pyrimidines V were obtained. Some newly
synthesized compounds were examined for their in vitro anti-inflammatory. Also all new compounds
were examined for their in vivo anti-microbial activity. Several derivatives showed a promising antiinflammatory activity in compared to ibuprofen. In this paper we examine and discuss the structureactivity relationships and anti-inflammatory activities of these compounds.
Key words
Pyrrolo (2.3-d)pyrimidine Anti-inflammatory activity Anti-microbial activity
2010
Journal
I.F =
Research
Title
Authors
Affiliation
Faculty of Pharmacy
NEW CONDENSED PYRROLES OF POTENTIAL BIOLOGICAL ITEREST SYNTHESES
AND STRUCTURE- ACTIVITY RELATIONSHIP STUDIES
Mosaad S. Mohamed a, Rehab Kamel b, Samar S. Fatahala a
a pharmaceutical organic Chemistry Department, faculty of Pharmacy, Helwan
University, Ain Helwan, Helwan-Egypt
b Toxicology and Pharmacology Department, Faculty of Pharrmacy, Helwan
University, Helwan, Egypt
Abstract
The Pyrrole derivatives la-d were prepared and utilized for the preparation of pyrrolo(2.3-d)
pyrimidine derivatives lIa-c, III, lVa-e, V and V1l1a-c: pyrrolo(3,2-e) tetrazolo(I,5-c)pyrimidine VI and
pyrrolo(4,3-e) (1,2,4 ) triazolo(I,5-c) pyrimidine derivative derivatives V1la-c. These some newly
synthesized compounds were examined for their in vitro antimicrobial activity and in vivo antiinflammatory. Result indicated that these compounds showed promising anti-inflammatory activity
in comparison to ibuprofen (the standard anti-inflammatory drug). The structure-activity
relationships (SAR) and anti-inflammatory activities of these compounds are also discussed in this
paper.
Key words
Pyrrole Pyrrolo(2,3-d)pyrimidine Strucrure- activitry- relationship Anti-inflammatory
activity Antimicrobial
2010
Journal
I.F =1.988
Research
Title
Authors
Affiliation
Faculty of Pharmacy
Molecules 2010, 15, 1882-1890; doi: I0.3390/molecules 15031882
SYNTHESIS OF CERTAIN PYRIMIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS
AND ANTI-INFLAMMATORY AGENTS
Mosaad S. Mohamed, Samir M. Awad and Amira Ibrahim Sayed *
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan
Abstract
A variety of novel bicyclic and tricyclic pyrimidine derivatives was obtained via reaction of 6-amino2-thioxo-1H-pyrimidine-4-one (1) with different reagents. The antimicrobial and anti-inflammatory
activities of some of the synthesized compounds were tested.
Key words
Pyrimidine; 6-amino-2-thioxo-1 H-pyrimidine-4-one; antimicrobial; anti –
inflammatory.
2011
Journal
I.F =3.193
Research
Title
Authors
Affiliation
Faculty of Pharmacy
SYNTHSIS AND KINETIC TESTING OF NEW INHIBITORS FOR A METALLO-βLACTAMASE FROM KLEDSIELLA PNEUMONIA AND PSEUDOMONAS AERUGINOSA
Mosaad S. Mohamed a, Waleed M. Hussein a,b, Ross P. McGeary b, c, Peter Vella b,
Gerhard Schenk b,d ,Rania H. Abd El-hameed a
a Helwan University. Pharmaceutical Organic Chemistry Department. Faculty of
Pharmacy. Ein Helwan. Helwan. Egypt
b The University of Queensland. School of Chemistry and Molecular Biosciences.
Brisbane. QLD 4072. Australia
c The University of Queensland. School of Pharmacy. Brisbane. Qld 4072. Australia
d National University of Ireland- Maynooth. Department of Chemistry. Maynooth. Co.
Kildare. Ireland
Abstract
There are currently no clinically useful inhibitors against metallo-β-lactamases (MBLs). enzymes that
confer resistance against a broad spectrum of commonly used antibiotics and that are produced by an
increasing number of bacterial pathogens. New pyrrole derivatives were synthesized and assayed for
their inhibitory effect on the catalytic activity of the IMP-' MBL from Pseudomonas aeruginosa and
Klebsiella pneumoniae. Six compounds tested (3a-3c. 5. 7 and 8) show micromolar inhibition
constants (K; values range from ~10 to 30 µM).ln silica docking was employed to investigate the
binding mode of the strongest inhibitor. 3b. in the active site of IMP-'. Implications for further
improvements of binding efficiency and specificity are discussed.
Key words
Pyrrole Pyrrolo(2.3-d)pyrimidine Metallo-β-lactarnase inhibitors Structure-activity
relationship.
2011
Journal
I.F =1.211
Research
Title
Authors
Affiliation
Faculty of Pharmacy
AAPS PharmSciTech 2011
FORMULATION, CHARACTERIZATION,AND CLINICAL EVALUATION OF
MICROEMULSION CONTAINING CLOTRIMAZOE FOR TOPICAL DELIVERY
Fahima M. Hashem,1 Dalia s. Shaker, 1 Mohamed Khalid Ghorab1 , Mohamed Nasr,1,2
and A1iaa Ismail1
1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of
Pharmacy, Helwan University, Cairo, Egypt.
2 To whom correspondence should be addressed. (e-mail: m2nasr@ yahoo.com)
Abstract
The objective of the present study was to formulate and evaluate microemulsion systems for topical
delivery of clotrimazole (CTM). The solubility of CTM in various oils was determined to select the oil
phase of the microemulsion systems. Pseudotemary phase diagrams were constructed to identify the
area of microemulsion existence. Five CTM microemulsion formulations (M1-M5) were prepared and
evaluated for their thermodynamic stability, pH, refractive index, droplet size, viscosity, and in vitro
release across cellulose membrane. Among the prepared microemulsion formulations, M3 (lemon oil
Tween 8OIn-butanollwater) and M4 (isopropyl myristate/Tween 80In-butanol/water)
microemulsion systems were found to be promising according to their physical properties and CTM
cumulative percentage release. Gel form of M3 and M4 were prepared using 1% Carbopol 940 as the
hydrogel matrix. Both formulations were evaluated in the liquid and gel forms for drug retention in
the skin in comparison to the marketed CTM topical cream and their stability examined after storage
at 40°C for 6 months. Microemulsion formulations achieved significantly higher skin retention for
CTM over the CTM cream. Stability studies showed that M4 preparations were more stable than M3.
The in vitro antifungal activity of M4 against Candida albicans was higher than that of the
conventional cream. Moreover, clinical evaluation proved the efficacy and tolerability of this
preparation in the treatment of various topical fungal infections
Key words
Clotrimazole; microemulsion; skin retention; topical cream; topical gel.
2010
Faculty of Pharmacy
Journal
I.F =1.246
Drug Delivery, 2010; 17(5): 282-287
Research
Title
PREPARATION AND CHARACTERIZATION OF NIOSOMES CONTAINING
RIBAVIRIN FOR LIVER TARGETING
Authors
Fahima Hashirri1, Mohamed El-Ridy2, Mohamed Nasr1, and Yasmin Abdallah1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy,
Helwan university Helwan Cairo,
11790 Egypt, and 2Department of Pharmaceutical Technology, National Research
'Center, Cairo, 11790 Egypt
Affiliation
Abstract
The objectives of this research were to prepare ribavirin niosomes and evaluate the influence of
niosomal encapsulation on drug liver targeting in rats. Ribavirin niosomes were prepared by the thin
film hydration method using span 60, cholesterol, and dicetyl phosphate in molar ratios of (1:1 :0),
(4:2:0). (1:1 :0.1), and (4:2:1). The prepared niosomes were characterized in vitro for vesicle size,
drug entrapment, drug release profiles, and vesicular stability at refrigerator temperature. The
results indicated that niosomes of the molar ratio (4:2:1) had a significantly (p < 0.05) higher
entrapment percentage of ribavirin than the other molar ratios, moreover, they revealed sustained
release characteristics as well as longer release pattern than other niosomal formulations.
Accordingly, niosomes of molar ratio (4:2:1) was selected for in vivo liver targeting study. Separately,
niosomal ribavirin dispersion and free ribavirin solution were administered as a single dose of 30
mg/kg by intraperitoneal injection into two groups of rats to compare the liver ribavirin
concentration. The obtained results show that the niosomal formulation significantly increased
ribavirin liver concentration (6-fold) in comparison with ribavirin-free solution. Based on the
previous results, the use of niosomes as a drug delivery system for ribavirin has significant liver
targeting properties, this is expected to improve the efficacy of low doses of ribavirin and minimize
its toxic sideeffects at higher doses.
Key word
Niosomes; ribavirin; liver targeting; antiviral; water-soluble drug
2010
Journal
I.F =4.956
Research
Title
Authors
Affiliation
Faculty of Pharmacy
The International Journal of Biochemistry & Cell Biology 42 (2010) 789-791
N1RC4/IPAF/CLAN/CARD12: MORE THAN A FLAGELLIN SENSOR
Dalia H. Abdelaziz a,b, Khaled Amr c, Amal O. Amer a
a Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for
Microbial Interface Biology and The Department of Internal Medicine, Ohio State
University, Columbus, OH 43210, United States
b Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan
C Department of Anesthesiology, West Virginia University, Morgantown, WV, United
States
Abstract
Nlrc4 is a member of the Nod-like receptors (NLRs),a family of cytosolic receptors involved in sensing
bacterial molecules. NLRs are a group of proteins containing spans of leucine-rich repeats that senses
bacterial factors within the eukaryotic cytosol. The recognition of bacterial factors provokes the
formation of the inflammasome complex which includes specific NLRs. The inflammasome is
responsible for caspase-1 activation which leads to the cleavage and maturation of inflammatory
cytokines such as IL- 113and lL-18.Nlrc4 was considered to be a devoted flagellin sensor in
eukaryotic cells. However, studies using a variety of pathogens such as Salmonella, Legionella,
Shigella and Pseudomonas at high bacterial burdens revealed that Nlrc4 can mediate caspase-1
activation independent of bacterial flagellin. On the other hand, new reports showed that Nlrc4 can
restrict bacterial infection independently of caspase-1. Therefore, Nlrc4 maybe involved in sensing
more than one bacterial molecule and may participate in several immune complexes.
Key words
Innate immunity NOD-like receptors Host-pathogen interaction Inflammasome
2010
Journal
I.F =
Research
Title
Authors
Affiliation
Faculty of Pharmacy
Acta Pharm. 61 (2011) 171-185
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME
6-ARY1-5-CYANO-2-THIOURACIL DERIVATIVES
Mosaad Sayed Mohamed, Samir Mohamed Awad and
Naglaa Mohamed Ahmed
Organic Chemistry Department Faculty of Pharmacy, Helwan University
Cairo, Egypt
Abstract
series of 6-aryl-5-cyano-2-thiouracil derivatives (la-d) was synthesized by the reaction of ethyl
cyanoacetate with thiourea and aldehydes. These products were used as intermediate compounds for
the synthesis of a number of thiouracil derivatives (2a-d to lOa-d). All compounds were screened for
antibacterial and antifungal activities. Some of the prepared compounds,6-(4-f1uorophenyl)-4--oxo2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide(2a),4-oxo-2-thioxo-6-(3,4,5- methoxyphenyl)1,2,3,4--tetrahydropyrimidine-5-carboxamide(2d),6-(4-fluorophenyl)-4-hydrazino-2-thioxo-l,2dihydropyrimidine-5-cabonitriIe(7a)and4-hydrazino-2-thioxo-6-(3,4,5-trimethoxyphenyl)-l,2dihydropyrimidine-5-carbonitrile (7d) revealed promising antimicrobial activity.
Key words
6-aryl-5-cyano-2-thiouracil, antibacterial activity, antifungal activity
2011
Journal
I.F =
Research
Title
Authors
Affiliation
Faculty of Industrial Education
International Journal of Automotive Technology, Vol. 12, No. 6, pp. 787-794 (2011)
COMBUSTON INSTABILITIES AND NANOPARTICLES EMISSON FLUCTUAYIONS IN
GDI SPARK IGNITION ENGINEE
A. E. Hassaneen¹, S.Samuel² and I. Whelan³
Department of Automotive Technology, Helwan University, Cairo, Egypt
School of Technology, Oxford Brookes University, OX33 lHX, U
Abstract:
The main challenge facing the concept of gasoline direct injection is the unfavourable physical
conditions at which the premixed charge is prepared and burned. These conditions include the short
time available for gasoline to be sprayed, evaporated, and homogeneously mixed with air. These
conditions most probably affect the combustion process and the cycle-by-cycle variation and may be
reflected in overall engine operation. The aim of this research is to analyze the combustion
characteristics and cycle-by-cycle variation including engine-out nanoparticulates of a turbocharged,
gasoline direct injected spark ignition (DISI) engine at a wide range of operating conditions. Gasoline
DISI, turbo-intercooled, 1.6L cylinder engine has been used in the study. In-cylinder pressure has
been measured using spark plug mounted piezoelectric transducer along with a PC based data
acquisition. A single zone heat release model has been used to analyze the in-cylinder pressure data.
The analysis of the combustion characteristics includes the flame development (0-10% burned mass
fraction) and rapid burn (10-90% burned mass fraction) durations at different engine conditions. The
cycle-by-cycle variations have been characterized by the coefficient of variations (COV) in the peak
cylinder pressure, the indicated mean effective pressure (lMEP), bum durations, and particle number
density. The combustion characteristics and cyclic variability of the DISI engine are compared with
data from throttle body injected (TBI) engine and conclusions are developed.
Key words
DISI engine, Cyclic variability, Combustion characteristics, Nanoparticulates
2011
Journal
I.F =0.844
Research Title
Authors
Affiliation
Applied Physics Letters/ Volume 97/ Issue 19/ ORGANIC ELECTRONICS AND
PHOTONICS
OPTICAL SECOND HARMONIC GENERATION AT HETEROJUNCTION
INTERFACES OF A MOLYBDENUM TRIOXIDE LAYER AND AN ORGANIC LAYER
A. B. El Basaty¹,² Y. Miyauchi,¹ G. Mizutani ¹ , T. Matsushima¹, and H. Murata¹
1School of Materials Science, Japan Advanced Institute of Science and Technology
(JAIST), Ishikawa 923-1292, Japan
2Department of Physics, Faculty of Science, Helwan University, Cairo 11795, Egypt
Abstract
We have observed optical second harmonic generation (SHG) from a space charge layer (SCL) in a
stacked indium tin oxide (ITO)/molybdenum trioxide (MoO3)/N−N′-diphenyl-N−N′-bis(1-naphthly)1,1′-biphenyl-4,4′-diamine (α-NPD) system. When the MoO3 thicknesses were increased, the SHG
signals from this system decreased sharply at smaller MoO3 thicknesses, and were saturated at MoO3
thicknesses larger than 1 nm. These results prove the vital role of SCL in improvement of drive
voltages of organic light-emitting diodes
Key words
2011
Journal
I.F =0.844
Research Title
Authors
Affiliation
Heat Mass Transfer (2011) 47:211-221
HEAT TRANSFER CHARACTERISTICS FROM ANARRAY OF THIN STRIPS PIN
FINS DUE TO THEIR EXPOSURES TO A SINGLE DOWNWARD JET
IMPINGEMENT
Eldesouki I. Eid. Abdalla G. Gomaa •
Mohamed E. Gomaa
E. I. Eid
Mechanical Department, Faculty of Industrial Education,
Suez Canal University, Suez, Egypt
e-mail: eldesukieidrsiyahoo.com
A. G. Gomaa
Refrigeration and Air Conditioning Department.
Faculty of Industrial Education, Helwan University, Cairo. Egypt
1. E. Gomaa
Technology Department, The Specialized Studies Academy,
Workers University, Ismailia, Egypt
Abstract
This paper investigates the heat transfer characteristics from thin strips pin fins due to their
exposure to a single circular downward air jet impingement. Five aluminum specimens were
considered; each one has a rectangular base of 84 mm x 78 mm and it has an array of about 300 thin
strips pin fins. A test rig consists mainly of air compressor; nozzle and protractor mechanism was
setup. Experiments were done to find out the effects of attack angle, Reynolds number, nozzle-totarget spacing, lateral pitch and parallel pitch among the fins on the heat transfer characteristics.
Empirical correlations were deduced to describe the experimental data. A CFD-numerical model was
introduced to monitor the now characteristics on a scale of more details than that possible in the
experimental work. The comparison among the results of the present work and those by the
literature shows about 50% improvement in heat transfer characteristics rather than the single jet
impingement onto flat plates, cylindrical surfaces, ribbed walls and multiple jets impingement onto
flat plates.
Key words
2011
Journal
I.F =0.844
Research Title
Authors
Affiliation
Boundary Value Problems 2011, 2011:45 doi:10.1186/1687-2770-2011-45
THE EQUICONVERGENCE OF THE EIGENFUNCTION EXPANSION FOR
ASINGULAR VERSION OF ONEDIMENSIONAL SCHRODINGER OPERATOR
WITH EXPLOSIVE FACTOR
Zaki FA EI-Raheem ¹ and AH Nasser ²
1 Department of Mathematics, Faculty of Education, Alexandria University,
Alexandria, Egypt
2 Faculty of Industrial Education, Helwan University, Cairo, Egypt
Abstract
This paper is devoted to prove the equiconvergence formula of the eigenfunction expansion for some
version of Schrodinger operator with explosive factor. The analysis relies on asymptotic calculation
and complex integration. The paper is of great interest for the community working in the area.
Key words
Eigenfunctions, Asymptotic formula, Contour integration,
Equiconvergence
2011
Journal
I.F =0.844
Research Title
Authors
Affiliation
Hindawi Publishing Corporation
Abstract and Applied Analysis
THE EIGENFUNCTION EXPANSION A DIRICHLAT PROBLEM WITH EXPLOSIVE
FACTOR
Zaki F. A. EI-Raheem1 and A. H. Nasser2
1 Department of Ma thenui tics, Faculty of Education, Alexandria University,
Alexanderia 21526, Egypt
2 Department of Mathematics, Faculty of Industria! Education, Heliuan University,
Cairo, Egypt
Abstract
The solutions of many problems of mathematical physics are reduced to the spectral investigation of
a differential operator or finding the expansion of arbitrary function, in series or integration, in terms
of the eigenfunctions of a differential operator. The differential operator is called regular if it its
domain is finite and its coefficients are continuous; otherwise it is called singular differential
operator. The Sturm-Liouville theory occupies a central position of the spectral theory of regular
operator. During the development of quantum mechanics, there was an increase in the interest of
spectral theory of singular operator on which we will restrict our attention. The first basic role in the
development of spectral theory of singular operator dates back to E. Ch. Tetchmarsh [1]. He gave a
new approach in the spectral theory of singular differential operator of the second order by using
contour integration. Also Levitan [2] gave a new method; he obtained the eigenfunction expansion in
infinite interval by taking limit of a regular case. In the last time about twenty five or so years, due to
the needs of mathematical physics, in particular, quantum mechanics, the question of solving various
spectral problems with explosive factor has been arisen. These appeared' also in the study of
geophysics and electromagnetic field, see Alemov [3]. The spectral theory of differential operators
with explosive factor is studied by A. N. Tekhanov, M. G. Krien, M. G. Gasimov, and others. In this
paper, we find the eigenfunction expansion formula and prove its convergence for following
Key words
2011
Journal
I.F =0.844
Research Title
Authors
Affiliation
Energy 36 (2011) 2788-2795
EXPERIMENTAL INVESTIGATION OF A VAPOR COMPRESSION HEAT PUMP
USED FOR A COOLING, AND HEATING PPLICATIONS
M. Fatouh, E. Elgendy
Mechanical Power Engineering Department. Faculcy of Engineering at EIMatroria. P.D.11718 (Masaken EI-Helmia). Cairo. Egypt
Abstract
The present work aims at evaluating the performance characteristics of a vapor compression heat
pump (VCHP)for simultaneous space cooling (summer air conditioning) and hot water supply. In
order to achieve this objective, a test facility was developed and experiments were performed over a
wide range of evaporator water inlet temperature (14:26QC)and condenser water inlet temperature
(22:34 QC). R134awas used as a primary working fluid whereas water was adopted as a secondary
heat transfer fluid at both heat source (evaporator) and heat sink (condenser) of the heat pump.
Performance characteristics of the considered heat pump were characterized by outlet water
temperatures, water side capacities and coefficient of performance (COP)for various operating modes
namely: cooling, heating and simultaneous cooling and heating. Results showed that COP increases
with the evaporator water inlet temperature while decreases as the condenser water inlet
temperature increases. However, the evaporator water inlet temperature has more effect on the
performance characteristics of the heat pump than that of condenser water inlet temperature. Actual
COP of cooling mode between 1.9to 3.1 and that of heating mode from 2.9 to 3.3 were obtained.
Actual simultaneous COP between 3.7 and 4.9 was achieved.
Key words
2011
Journal
I.F =0.158
Research
Title
Authors
Affiliation
Faculty of Nursing
Life Science Journal, 2011 ;8(2)
AWARENESS OF HOSPITAL INTERNL DISASTER MANAGEMENT PLAN AMONG
HEALTH TEAM MEMBERS IN A UNIVERSITY HOSPITAL
Hemat Abd elazeem 1 , Samia Adam *1, and Gehan Mohamed2
1Faculty of Nursing, Ain Shams University, Cairo, Egypt
2 Faculty of Nursing, Helwan University, Helwan, Egypt. *[email protected]
Abstract
A disaster management plan is a formal plan of action which enables the hospital staff to respond
effectively and efficiently when confronted with a disaster, The aim of this study was to assess the
awareness of health team regarding hospital internal disaster management plan at a university
hospital. The study was conducted in a university hospital using a cross-sectional design. It included
six groups of subjects namely, medical leaders, head nurses, staff nurses, technicians, employees,
housekeepers, in addition to a jury group to test validity of the study tool. A self-administered
questionnaire form was used to assess staff awareness about the internal disaster management plan i
the hospital. The results showed the absence of a disaster plan in the study setting and absence of a
hospital evacuation plan. Also the majority of various categories of the study subjects had low
awareness about all items of the disaster plan. It is concluded that there is a need for an internal
disaster plan for the hospital, and the awareness of study subjects about internal disaster
preparedness need to be raised. Therefore, it is recommended that the hospital administration should
develop policies for disaster management and pay more attention to the problem of internal disasters
and preparedness for their management. Training programs are essential for all categories of hospital
staff in order to increase their awareness about disaster management.
Key words
Internal disaster, disaster management plan, hospital preparedness
2011
Journal
I.F =0.158
Research
Title
Authors
Affiliation
Faculty of Nursing
Life Science Journal, 2011;8(4)
POMOTING LIFE STYLE AMONG SHELTERED SCHOOL CHILDREN IN BANHA CITY,
QUALIOBIA GOVERNORATE
1 Sahar A. Sh. Mahmoud and 2 Magda A. Ahmad
1Community Health Nursing, Faculty of Nursing, Helwan University, Cairo, Egypt
2Community Health Nursing, Faculty of Nursing, Ain Shams University, Cairo, Egypt
[email protected]
Abstract
Shelter is a place affording protection against danger, or it is a structure that provides privacy and
protection for children who have no fixed night time residence. This study aims to evaluate the effect
of nursing intervention on promoting life style of school children's shelters in Banha City, Qualiobia
Governorate. Design: A quasi experimental design was used to conduct the study. Setting: This study
was carried out at two shelters, affiliated to social welfare institutions for boys and girls in Banha City
in the academic years 2009 /2010. Sample: All children 55: 36 boys &19 girls in primary, preparatory
and secondary school ages (6-18 years). Tool: Three Tools were used for data collection: 1) An
interviewing questionnaire for the children concerning socio-demographic characteristics.2)
Assessment of health problems: physical, social, psychological and emotional problems:
(a)Psychological tests as Fear and Anxiety Test, Poor Relationships, Depression Test, and Emotional
Test),(b) Social problems: violence Test, Withdrawal Test and Sexual Abuse Test, 3): Life Style
Assessment Sheet. Results: Revealed that the majority of the studied subjects were males, more than
two thirds had basic education, according to their health problems, there were statistically significant
improvements after the intervention .Concerning self health responsibilities, the mean was 31.222,
32.053 pre program which improved to 50.456, 50.150 after program, the nutritional awareness
mean was 28.139, 29.158 pre program, improved t9 34.540, 35.150 with a significant difference at p=
<0.00 I. Statistically, there were improvements after the intervention program in physical activity,
stress management and environmental safety. Coclusion: The results revealed a significant effect of
the intervention program in promoting life-style and providing favorable impact on the health
condition of children's shelters. The finding of this study recommended the need for integration
between Ministry of Health and Ministry of Society Affairs and Solidarity to develop healthcare
services such as providing periodic check up under supervision of the Ministry of Health and
providing shelters with nurses working for 24 hrs/day.
Key words
shelter children's, health needs, health problems, life style promotion
2011
Journal
I.F =2.239
Research
Title
Authors
Affiliation
Faculty of Home Economics
Lipids in Health and Disease 2011, 10:114
CAN APRICOT KERNELS FATTY ACIDE THE ATROPHIED HEPATOCYTES FEOM
PROGREAAION TO FIBROSIS IN DIMETHYHLNITROSAMINE ( DMN ) – INDUCED
LIVER INJURY RATS?
Manal K Abdel-Rahman
Nutrition and Food Science Department. Faculty of Home Economics,
Helwan University, Cairo, Egypt
Abstract
Background and aims: The present study was aimed to analyze the chemical composition of ground
apricot kernel (GAK) and examine its effect on hepatic fibrosis in vivo induced by
dimethylnitrosamine (DMN) in rats. Methods and results: Hepatic fibrosis was induced by
intraperitoneal injections of 10 mg/kg DMN for 3 consecutive days each week over a period of 4 wk.
The rats were randomly assigned to five groups of nine rats each: the negative control group (NC),
the hepatic fibrosis group (PC), hepatic fibrosis supplemented with GAK (0.5mg/kg/BW/rat), hepatic
fibrosis supplemented with GAK (1 mg/kg/BW/rat) and hepatic fibrosis supplemented with GAK (1.5
mg/kg/BW/rat). Rats were killed, blood was collected and livers were excised for biochemical
measurements and histological examination. Results indicate that the diet supplemented with GAK
led to improving liver function, lipid peroxides, and liver CAT, SOD and GSH. These results were
confirmed by liver histology. Hierarchically high levels f GAK (1.5 mg/kg/BW/rat) gave the best
results compared to other tested levels. Conclusion: This study demonstrates that GAK
administration specifically (1.5 mg/kg/BW/rat) can effectively improve liver fibrosis caused by DMN,
and may be used as a therapeutic option and preventive measure against hepatic fibrosis.
Furthermore, a human trial would be applied specially GAK is a part of Egyptian diet. The act of why
high amounts of GAK was improved biochemical values compared to low or moderate levels tested in
this study may be due to increase levels of oleic acid and other polyphenols in apricot kernels.
Key words
Ground apricots kemel (GAK), Antioxidant activity, Cyanide, Dimethylnitrosamine,
Liver fibrosis.

Faculty of Engineering at Helwan 2011

Transcription

Similar documents

the world

CV - Zahran

Mideast Monitor Column/The Jerusalem Report — September 9, 2013

2 FOR 1

1)What is meant by “assimilation”?

EGYPT Infographic English

w.en.28-2-2016 - media2.wataninet.com

The history - Jardin des Dominicains du Caire

Online Advertisement

w.en 22-5-2016