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www.FormulaScan.com - Patents listed by Formula Scan were retrieved by parsing the claims in the original documents.
Our lists have greater than 95% relevance to the subject
Nanotechnology in Personal Care
Consumer Products
Nanotechnology-based Consumer Products
Currently in the Market.
After more than twenty years of exploratory and applied research, nanotechnologies are
gaining popularity in commercial use, fundamentally due to the unique properties that are
capable to impart to consumer products. Nanoscale materials now are in electronic,
cosmetics, automotive and medical products. But it has been difficult to find out how many
“nano” consumer products are on the market and which merchandise could be called “nano.”
This inventory list gives the general public and industry at large the best available look at more
than one thousand products identified by its manufactures as nanotechnology-based
consumer products.
Inventory of Products and Intellectual Property
Prepared by
Formula Scan™ Research Associates
Friday, October 02, 2009
This document was prepared by www.FormulaScan.com. Its reproduction in any type of form or format is strictly prohibited without
the written consent of Formula Scan
Table of Contents
Inventory of Cosmetics Products ........................................................................................................................ 3
Inventory of Personal Care Products ................................................................................................................ 14
Inventory of Sunscreen Products ...................................................................................................................... 29
Patents in Nanotechnology-based Consumer Products ................................................................................... 32
Nanotechnology Patents Granted by Country: ......................................................................................... 32
Nanotechnology Patents Granted by Company: ....................................................................................... 34
US PATENTS IN NANOTECHNOLOGY FOR HAIR CARE....................................................................................... 36
GRANTED FROM 1980 TO 2008 ............................................................................................................... 36
US PATENT APPLICATIONS IN NANOTECHNOLOGY FOR HAIR CARE .............................................................. 102
PUBLISHED FROM 1980 TO 2008 .......................................................................................................... 102
US PATENT APPLICATIONS IN NANOTECHNOLOGY FOR SKIN CARE .............................................................. 125
PUBLISHED FROM 2001 TO 2008 .......................................................................................................... 125
US PATENTS IN NANOTECHNOLOGY FOR SKIN CARE ..................................................................................... 203
GRANTED FROM 1980 TO 2008 ............................................................................................................. 203
Inventory of Cosmetics Products
Acnel Lotion N
DERMAVIDUALS® U.S.A.
Health and Fitness >
Cosmetics
Arbonne
NutriMinC® RE9 Products
Arbonne International Health
and Fitness > Cosmetics
Bain de Terre®
Recovery Complex® Zotos
International, Inc. Health and
Fitness > Cosmetics
bĭm·ə·nē
Telemolecular Health and
Fitness > Cosmetics Health
and Fitness > Personal Care
Arouge Deep
NanoMoisture™ Care Set
Zenyaku Kogyo Co., Ltd.
Cosmetics
Beautiful Face
Series--Nano-in Deep
Cleaning for make-up removal
and exfoliation and Cleaning
Gel Nano-Infinity Nanotech
Co., Ltd. Health and Fitness >
Cosmetics
Calming Emulsion
Chanel® Health and Fitness >
Cosmetics
Alusion™ Alumina
Powders Advanced
Nanotechnology Limited
Cosmetics Generic
Awake Nano
Lotion White KOSÉ®
Corporation Health and
Fitness > Cosmetics
BIONOVA
Cosmetics Barneys York®
Cosmetics
Chantecaille Nano
Gold Energizing Cream
Chantecaille Health and
Fitness > Cosmetics
Clearly It! ™
Complexion Mist Kara Vita
Cosmetics Health and Fitness
> Personal Care
Coco
Mademoiselle Fresh Moisture
Mist Chanel® Health and
Fitness > Cosmetics
Cosil Whitening
Mask Natural Korea
Company, Ltd. Health and
Fitness > Cosmetics
D-Fense™ Antioxidant
Moisturizer with SPF 17
MOXIE for men Health and
Fitness > Cosmetics
Clearly It! ™ Spot
Treatment Kara Vita Health
Health and Fitness > Personal
Care
CollagenFusion™
Botanical Skincare System
AmerElite Solutions® Health
Crystal Radiance
JamieO Skincare Health and
Derma Swiss
Nanosphere DermaSwiss
Cosmetics NEW
Clearly It!™ Acne
Treatment Lotion Kara Vita
> Personal Care
Cosil Nano Beauty
Soap Natural Korea
Fitness > Cosmetics
Cuticle Tender™
Kara Vita Health and Fitness
> Cosmetics Health and
Fitness > Personal Care
Diorskin Forever Extreme Wear Flawless
Makeup FPS 25 Dior® Health
Care
DiorSnow Pure UV
Base SPF 50 Dior® Health
DNA Skin
Optimizer, SPF 20, Cream
JUVENA (International) AG
Cosmetics
DNA Skin
Optimizer, SPF 20, Fluid
JUVENA (International) AG
Cosmetics
Doctor Gunderson's
Rãahj Nano Copper Facial
Spray Freedom Plus
Fitness > Cosmetics
Doctor Gunderson's
Rãahj Synergized DHEA
Facial Spray Freedom Plus
Corporation Health and Fitness
> Cosmetics
Dual Finished
Pressed Compacts
ColorScience® Health and
Fitness > Cosmetics
Eczemel NanoCream DERMAVIDUALS®
U.S.A. Health and Fitness >
Cosmetics
Eternalis™
Hydrating Face Mist Beyond
Skin Science, LLC™ Health
Eternalis™ Skin
Purifying Cleanser Beyond
Skin Science, LLC™ Health
EGF Complex
Cocktail BellaPelle™ Health
Eternalis™ Intense
Day Treatment Beyond Skin
Science, LLC™ Health and
Fitness > Cosmetics
Everyday Skin™
Penetrating Cream Kara Vita
> Personal Care
Enlighten Me! ™
Eternalis™ Night
Cream Beyond Skin Science,
LLC™ Health and Fitness >
Cosmetics
Eye Contour
Nanolift Euoko Health and
Fitness > Cosmetics
Eye Tender™
Flash Bronzer
Glow 'N Wear Lancome®
Cosmetics
Glycol-X
> Personal Care
HYDRA FLASH®
BRONZER Daily Face
Moisturizer Lancome®
Cosmetics
EyeWish!™
Bioserum Kara Vita Health
Care
Fresh As A
Daisy™ Body Lotion Kara
Vita Health and Fitness >
> Personal Care
GreenYarn Gmoist soft cloth mask
Greenyarn LLC. Health and
HYDRA ZEN®
CREAM Lancome® Health
Face Brushes-After Glow Brush and Brush
Colores ColorScience® Health
Glycol-X
Treatment Cream Kara Vita
> Personal Care
Hand Tender™
Indulgence™ Kara
> Personal Care
Infiniti by
Conair™ High Steam
Straightener Conair Health
Care
Infiniti Nano Silver
by Conair™ Hairsetter Conair
> Personal Care
Infiniti Nano
Silver by Conair™
Tourmaline 1 Straightener
Conair Health and Fitness >
> Personal Care
by Conair™ Tourmaline 1¾
Straightener Conair Health and
IPosture IPosture
Cosmetics
Komenuka Bijin
NSK A-10 Cream UNICO
Enterprises Health and Fitness
> Cosmetics
Komenuka Bijin
NSK C-10 Essence UNICO
Enterprises Health and
Fitness > Cosmetics
Lancome®
Rénergie® Flash Lifting
Lancome® Health and Fitness
> Cosmetics
Lancome®
Rénergie® Microlift
Lancome® Health and Fitness
> Cosmetics
Lancome®
Rénergie® Neck Lancome®
Cosmetics
Laser in a Bottle™
Products Dr Brandt Health
Komenuka Bijin
NSK C-10 Essence Komenuka
Bijin Health and Fitness >
Cosmetics
Lancome®
Rénergie® Microlift Eye
Lancome® Health and
Fitness > Cosmetics
by Conair™ Straightener
> Personal Care
INNERMOST
Cosmetics Enprani® Health
LEOREX®
Cosmetics GlobalMed®
Technologies Health and
Fitness > Cosmetics
Lipoduction™
Body Perfecting Complex
Osmotics® Cosmeceuticals
Cosmetics
Nano Breast
Cream St. Herb Cosmetics
International® Health and
Fitness > Cosmetics
Nano Gold
Energizing Cream Neiman
Marcus Health and Fitness >
Cosmetics
Nano Weight Pro
1900 Turbo FHI Heat
Platform Health and Fitness >
> Personal Care
LifeWave
NanoTechnology Skin Care
System LifeWave, LLC Health
Generic
Lip Tender™ Kara
> Personal Care
Lyphazome® and
Celazome® Cosmetics and
Sunscreens Dermazone
Solutions Health and Fitness >
> Sunscreen
Nano Anti Aging
Cream Soxton Enterprise
Cosmetics
Nano Cosmetics
SongSing Nano Technology
Cosmetics
Nano Cyclic
Cleanser PINK NanoCyclic,
Inc. Health and Fitness >
Cosmetics
Nano Salon Pro
2000 FHI Heat Platform
> Personal Care
Nano Weight Pro
> Personal Care
Nano-C® powder
Cosmetics Cell Rx® Health
Nano-in Hand and
Nail Moisturizing Serum and
Foot Moisturizing Serum
Nano-Infinity Nanotech Co.,
Ltd. Health and Fitness >
Cosmetics
Nano-mascara
Nano Concept Health and
Fitness > Cosmetics
Appliances >
Nanoseal
G.N.C. NanoPlasma Center
Fitness > Cosmetics
Nourish
BellaPelle™ Health and
Fitness > Cosmetics
Peroxel Gel
Cosmetics
POUTlandish
Hyper Moisturizing Lip
Paint® DERMAdoctor®
Cosmetics
Nanoce Moisture
Liquid Foundation Ishizawa
Labs Health and Fitness >
Cosmetics
Nanorama - Nano
Gold Mask Pack Lexon
Nanotech, Inc. Health and
Fitness > Cosmetics
Nanoseal
G.S.E. NanoPlasma Center
Fitness > Cosmetics
NanosealHairna essence NanoPlasma
Center Company, Ltd. Health
NutraFirm™ Body
Wash and Lotion RBC Life
Sciences®, Inc. Health and
Fitness > Cosmetics
Platinum Silver
Nanocolloid Cream DHC
Skincare Health and Fitness >
Cosmetics
Primordiale
Nanolotion Lancome® Health
Oleogel
Cosmetics
Platinum Silver
Nanocolloid Milky Essence
DHC Skincare Health and
Fitness > Cosmetics
Primordiale
Optimum Lip Lancome®
Cosmetics
Psorinel Lotion
Cosmetics
Pureology®
Nanowax Pureology® Health
Care
Radical
Sponge® (Fullerene) Vitamin
C60 BioResearch
Fitness > Cosmetics
Generic
Rewind Time
Pureology® Nano
Glaze Pureology® Health and
Q10 Skin Care Nano Lipobelle
Coenzyme Q10 Tina Concept
Cosmetics Food and Beverage
>
RevitaLift®
Double Lifting L’Oreal®
> Personal Care
Rutína nano-force
moisturizer KOSÉ®
Corporation Health and Fitness
> Cosmetics
Pureology® Nano
Works Shine Luxe - Finishing
Hair Polish Pureology®
> Personal Care
Quan Zhou Hu
Zheng Nano Technology Co.,
Ltd.® Nano-gold Mask Quan
Zhou Hu Zheng Nano
Technology Co., Ltd.® Health
RevitaLift®
Intense Lift Treament Mask
L’Oreal® Health and Fitness
> Cosmetics
Rutína nano-white
KOSÉ® Corporation Health
Serge Lutens
Blusher Barneys York®
Cosmetics
Shiseido 'The
Makeup' Dual Balancing
Foundation SPF 17
NEW
Sircuit® O.M.G.™
SERUM Sircuit®
Cosmeceuticals Inc. Health
Sircuit® Sircuit
Addict™ version 1.0 Sircuit®
Cosmeceuticals Inc. Health
Soothing
Moisturizing Lotion
Nanoemulsion 10-9 G.M.
Collin Health and Fitness >
Cosmetics
StriVectin™-NE
NanoExfoliant For The
Hands™ StriVectin™ Health
SunVex®
Sunscreens SunVex Health
Sunscreen
Super "h" Serum 3Lab
Cosmetics NEW
Sircuit® White Out
Sircuit® Cosmeceuticals Inc.
Cosmetics
Skin Caviar
Ampoules Bergdorf
Goodman® Health and
Fitness > Cosmetics
SunVex®
Dailywear Lotions SunVex
> Sunscreen
SUPER AQUA
Cosmetics Enprani® Health
Susie-K Nano
Beauty Soap Segae-I Pte Ltd.
Cosmetics
Susie-K Whitening
Mask Segae-I Pte Ltd. Health
TIME
RESPONSE® Eye Renewal
Creme AmorePacific® Health
TIME
RESPONSE® Intensive Skin
Renewal Ampoule
AmorePacific® Health and
Fitness > Cosmetics
TIME
RESPONSE® Skin Renewal
Creme AmorePacific® Health
Turn The Tides
Blemish Serum
ColorScience® Health and
Fitness > Cosmetics
Up Tight™
Firming Peptide Complex Kara
> Personal Care
Up Tight™
Firming Peptide Cream Kara
> Personal Care
VECTEANA Clear
Wash Faith Cosmetics Group
Cosmetics
VECTEANA
Nanomode Essence RC Faith
Cosmetics Group Health and
Fitness > Cosmetics
VECTEANA
White Powder Faith
Cosmetics Group Health and
Fitness > Cosmetics
Vital Essence with
Arbutin Chantecaille Health
Care NEW
WW Eye Cream
3Lab Health and Fitness >
Cosmetics
Zelens® Fullerene
C-60 Day Cream Zelens®
Cosmetics
Zelens® Fullerene
C-60 Eye Cream Zelens®
Cosmetics
Zelens® Fullerene
C-60 Night Cream Zelens®
Cosmetics
UV Pearls Sol-Gel
Technologies Health and
Fitness > Cosmetics
Generic
The Skin
Lightening Collection
Porselene Health and Fitness
> Cosmetics
Inventory of Personal Care Products
Acticoat® Wound
Dressings Smith & Nephew
Care Generic
Ain Supplio Pencil
Pentel Goods for Children >
Basics Health and Fitness >
Personal Care Generic
Ag Nano
Phytoncide Toothpaste SH
Pharma Co Ltd Health and
Alpha Amino
Prototype 216 MuscleTech
Care NEW
Ag plus Nano Technology
Ionic Dryer Metropolis
Technology Health and
Andis Elevate 3/8"
Nano-Silver Gold Infused
Curling Iron ANDIS Health
Andis Elevate 1
1/4" Nano-Silver Gold
Infused Curling Iron ANDIS
Care
Andis Elevate 1"
Nano-Silver Gold Infused
Curling Iron ANDIS Health
Andis Elevate 1-1/2
Nano Silver Gold Curling Iron
ANDIS Health and Fitness >
Personal Care
Andis Elevate 3/4"
Nano Silver Gold Curling
Iron ANDIS Health and
Antibacterial
Make-up Instrument Nano
Care Technology, Ltd. Cross
Cutting > Coatings Health and
Apagard® Oral
Care Toothpaste Sangi Co.,
Personal Care
Bidet BID-8200
Tong Yang Magic Co., Ltd
Care
Bidet UB-2235 and
UB-2235R Samhongtech Co.,
Personal Care
Back Supporter
Vital Age Health and Fitness
> Personal Care
bĭm·ə·nē
Telemolecular Health and
Body Volume
Conditioner COLURE True
Color Care Health and
Body Volume
Shampoo COLURE True
Color Care Health and Fitness
> Personal Care NEW
CERAMIC or
TITANIUM HAIR
STRAIGHTENER Turboion
Care
CHI Nano Ceramic
Hairstyling Iron Chi Hair
Products Health and Fitness >
Personal Care NEW
Clearly It! ™
Complexion Mist Kara Vita
> Personal Care
Conair Infiniti
Nano Silver Hair Dryer with
Adjustable Diffuser Conair
Care Appliances >
Clearly It! ™ Spot
Treatment Kara Vita Health
Care
Conair Nano Silver
Tourmaline Ceramic Hair
Designer Conair Health and
NEW
CleanXchange™
Foil Shaver Remington®
Care
Clearly It!™ Acne
> Personal Care
Cordless LED
Curing Light ( Model :
SlimLED ) B&B Systems Co
Care
CROC Infra-Red
Turboion Health and Fitness
> Personal Care
Curlwave Styling
Crème COLURE True Color
Care Health and Fitness >
Personal Care
Daejanggum
Yellow Earth Phlogopite Soap
Claypia Co,.Ltd Health and
Elbow Supporter
> Personal Care
CROC SEMI-DIGI
FLAT IRON Turboion Health
NEW
Crystal Radiance
Cuticle Tender™
Kara Vita Health and Fitness >
> Personal Care
Cyclic Nano Silver
Cleanser NanoCyclic, Inc.
Care
Destiny nFusion™
Hearing Aid Starkey, Inc.
Electronics and Computers >
Audio Health and Fitness >
Personal Care
Emergency
Filtration Products
NanoMask® Emergency
Filtration Products Health and
Fitness > Filtration Health and
Diorskin Forever Extreme Wear Flawless
Makeup FPS 25 Dior® Health
Care
Energy Booster
Serum ALFAPARF Milano
Care
Energy Enhancer
LifeWave, LLC Health and
Enlighten Me! ™
Kara Vita Health and Fitness >
> Personal Care
Everyday Skin™
Penetrating Cream Kara Vita
> Personal Care
Exfoliant Gelscrub
ALFAPARF Milano Health
EyeWish!™
Bioserum Kara Vita Health
Care
Finy No.5 Glasses Finy Health and
Fitness > Personal Care NEW
First Response®
Home Pregnancy Test CarterWallace® Health and Fitness
> Personal Care
Flex-Power® Joint
& Muscle Pain Relief Cream
Flex-Power®, Inc. Health and
Equilibre Nano
Silver Cleanser
EVELINECHARLES™
SALONS and SPAS Health
Eye Tender™ Kara
> Personal Care
FirmHold Styling
Gel COLURE True Color
Care Health and Fitness >
Personal Care
Foot Massager
HYUNDAI Wacor Tec.Co.,
Personal Care
Fresh As A
Daisy™ Body Lotion Kara
> Personal Care
Glycol-X
> Personal Care
Hair Iron SE
International Health and
Fitness > Personal Care Cross
Cutting > Coatings
Hand Tender™
FX Diamond®
Razor Wilkinson Sword® Ltd.
Care
Glycol-X
Treatment Cream Kara Vita
> Personal Care
GreenYarn Gmoist soft cloth mask
Greenyarn LLC. Health and
HAI Elite Nano XT
Tourmaline Flat Iron, 1 Hai
Care
Hair Power NanoTech Solutions Shampoo
Hearing Instrument
Siemens® Hearing Instruments
Electronics and Computers >
Audio Health and Fitness >
Personal Care
Hand Dryer Royal
TOTO Co., Ltd. Health and
Fitness > Filtration Health
Helix™ Deep
Waver Hot tools® Health and
Helix™ Dryer Hot
tools® Health and Fitness >
Personal Care
Helix™ Flat Irons
Hot tools® Health and Fitness
> Personal Care
Helix™Curling
Irons Hot tools® Health and
Hot Ice Thermal
Patch™ LifeWave, LLC
Care
HGX-1
CleanXchange SureSource
LLC. (Remington) Health and
High Precision™
Personal Grooming Kit
Remington® Health and
Hot Tools Nano
Ceramic Wax-Core
Professional Hair Setter Hot
tools® Health and Fitness >
Personal Care
Indulgence™ Kara
> Personal Care
Infiniti by Conair
Professional Nano Silver
Tourmaline Ceramic Styler
Personal Care
Infiniti by
Conair™ High Steam
Straightener Conair Health
Care
by Conair™ Hairsetter Conair
> Personal Care
by Conair™ Straightener
> Personal Care
Infiniti Nano
Silver by Conair™
Tourmaline 1 Straightener
> Personal Care
by Conair™ Tourmaline 1¾
Straightener Conair Health and
Keratin Reinforcer
Lion® Ban Powder
Spray Lion® Corporation
Care
Lucky Silver Nano
Toothbrush LK Trading Co.,
Personal Care
Nanbabies®
Face Masks Nanbabies®
Care
Lip Tender™ Kara
> Personal Care
Mosquito Repellent
Spray J International CityM
Korea Co., Ltd. Health and
Nanbabies®
Foot/Shoe Care Nanbabies®
Care
Nano & UV
Artificial Teeth Cleaner
Digimax Innovative Products
Ltd Health and Fitness >
Personal Care
Nano Cyclic Towel
NanoCyclic, Inc. Health and
NEW
Nano Dryer CHI®
Cationic Hydration Interlink
Care
Nano Facial Ionic
Steamer Panasonic® Hong
Kong Health and Fitness >
Personal Care
Lissage Nano Silver
Cleanser
EVELINECHARLES™
SALONS and SPAS Health
Nanbabies®
Element 47 Moisturizing
Spray Nanbabies® Health and
Nanbabies®
Sleeves and Braces
Nanbabies® Health and
Nano Digital Iron
CHI® Cationic Hydration
Interlink Health and Fitness >
Personal Care
Nano Magic White
Body Soxton Enterprise
Care
Nano Salon Pro
> Personal Care
Nano Silver 650 Beauty Soap
DongYang Nanotech Co. Ltd
Care
NanO Silver Nano
Health Solutions Health and
Nano Silver Wet Wipes
Nanogist Co., Ltd. Health and
Fitness > Personal Care Home
and Garden > Cleaning
Nano Silver
Anti-Bacterial Baby Bottle
Brush Sang Shin Industrial
Personal Care Goods for
Children > Basics
Nano Silver
Toothpaste Ace Silver Plus
Care
Nano Toothbrush
Gabiamall Health and Fitness
> Personal Care
Nano Toothbrush
SongSing Nano Technology
Personal Care
Nano Weight Pro
> Personal Care
Nano-in Body
Freshness Control NanoInfinity Nanotech Co., Ltd.
Care
Nano-in Foot
Deodorant Powder/Spray
Nano-Infinity Nanotech Co.,
Personal Care
Nano-silver
Toothbrush Summitek Inc.
Care
Nano-silver
Toothpaste Summitek Inc.
Care
Nano Weight Pro
1900 Turbo FHI Heat
Platform Health and Fitness >
> Personal Care
Nano-silver Aroma
Soap Summitek Inc. Health
Nano-silver Women
Antimicrobial Gel for
External Use Health & Health
(Hong Kong) International
Holdings Ltd. Health and
Nanogen®
Nanofibers Nanogen®
Personal Care
Nanogen®
Nanoscalp Nanogen®
Personal Care
Nanorama - Gold
Toothpaste Lexon Nanotech,
Personal Care
Nanoceuticals™ Citrus
Mint Shampoo RBC Life
Sciences®, Inc. Health and
Nanogen®
Nanogaine Nanogen®
Personal Care
Nanogen®
Nanothick Nanogen® Products
Care
Nanorama - Nano
Beauty Soap Lexon Nanotech,
Personal Care
Nanogen® Locking
Mist Nanogen® Products
Care
Nanogen®
Nanoguard Nanogen®
Personal Care
Nanometer-Silver
Foam Condom Blue Cross
Bio-Medical (Beijing) Co.,Ltd.
Care
Nanoseal
Toothpaste NanoPlasma
Center Company, Ltd. Health
NANOVER™ Wet
Wipes GNS Nanogist Goods
for Children > Basics Health
NANOVER™
Cleansing Soap GNS Nanogist
Care
NANOVER™ Hair
Care GNS Nanogist Health
NANOVER™
Mask Pack GNS Nanogist
Care
NANOVER™
Toothpaste GNS Nanogist
Care
Nanowhitening Swissdent
Care
naNOX9 Hardcore
MuscleTech Health and
Natural
Ingredients( Model : Face
Foam ) Gaia Infonet Co., Ltd.
Care
Natural
Ingredients( Model: Body
Foam ) Gaia Infonet Co., Ltd.
Care
neosino Sport
Nano-Liquid Neosino Health
Health and Fitness > Sporting
Goods
New Hair Brushes
AWIN Corporation Health and
NoFog+clean
HOLMENKOL SportTechnologies GmbH & Co.
KG Cross Cutting > Coatings
Care
Norwex's Silver
Care Plus Self Sanitizing
Toothbrush Norwex Health
Panasonic® Arc
with Vortex Cleaning System
Wet Dry Shavers Panasonic®
Personal Care
Professional
Hair Brush Sang Shin
Industrial Co., Ltd. Health
Pureology®
HoldFast Pureology® Health
Pureology®
Nanowax Pureology® Health
Care
Oragan Nano
Silver Toothpaste LK Trading
Personal Care
Perfect Mask 3Lab
Care NEW
Panasonic ES8228S
Vortex Nano Shaver
Panasonic® Inc. Health and
PG-400 High
Precision™ All-in-1 Personal
Grooming Kit Remington®
Care
Professional
Styling Iron with Nano
Technology FHI Heat Platform
Care
Pureology®
COLOURMAX Pureology®
Care
Pureology® Nano
Glaze Pureology® Health and
Pureology® Nano
Works Shine Luxe - Finishing
Hair Polish Pureology®
> Personal Care
Pureology®
Nanoworks Conditioner
Pureology® Health and Fitness
> Personal Care
Pureology®
Nanoworks Shampoo
Pureology® Health and
Quan Zhou Hu
Ltd.® Gold Nanoparticle
soaps Quan Zhou Hu Zheng
Nano Technology Co., Ltd.®
Care
Quan Zhou Hu
Ltd.® Nano-silver Toothpaste
Quan Zhou Hu Zheng Nano
Technology Co., Ltd.® Health
Remington
Essentials Epilator with Nano
Silver and Shaving Head
Attachment, EP5000
Remington® Health and
RestQuiet Patch
RevitaLift® Double
Lifting L’Oreal® Health and
Richly Moisturize
Conditioner COLURE True
> Personal Care NEW
Richly Moisturize
Shampoo COLURE True
> Personal Care
Royal Hygiene
Bidet Royal TOTO Co., Ltd.
Care
S-Nano Ionic
Dryer Metropolis Technology
Care
S-Nano Ionic Iron
Metropolis Technology Health
S-Nano Paddle
Brush Metropolis Technology
Care
S-Nano Round
Boar Brushes Metropolis
Technology Health and Fitness
> Personal Care NEW
S-Nano Thermal
Brushes Metropolis
Resists Static
Fabric Nano-Tex®, Inc., LLC
Care
Rewind Time
S-Nano Tunnel
Vent Brush Metropolis
Shine Serum
COLURE True Color Care
Care NEW
Shuga™ Hair
Products Ariella, Inc. Health
SoleFresh™ Socks JR
Nanotech PLC Health and
Fitness > Clothing Health and
StraightHair
BlowDry Crème COLURE
True Color Care Health and
Silent Nights
NEW
SP6 LifeWave,
LLC Health and Fitness >
Personal Care NEW
Swissdent
Nanowhitening Toothpaste
Swissdent Health and Fitness >
Personal Care
Shiseido 'The
Makeup' Dual Balancing
Foundation SPF 17
Silver Colloid for
Antimicrobial in Exterior
Medicine Shanghai Huzheng
Nano Technology CO.,LTD
Care
Stainless Toothpaste
Swissdent Health and Fitness
> Personal Care
T-Studio Nano
Collection Remington®
Care
The Handler Handler Health
Texture Crème
COLURE True Color Care
Care
TIGI Bed Head
Tourmaline Nano-Ceramic
Styling Iron Tigi Health and
Toothpaste Gel
Gaia Infonet Co., Ltd. Health
Tourmaline Nano
Ceramic Straightener Bed
Head® Health and Fitness >
Personal Care
Theramed S.O.S.
Sensitive toothpaste with
Nanit®active Henkel KGaA
Care
Toasty Feet
Polarwrap® Health and Fitness
> Personal Care
Toothbrush
Sterilizer & Bathroom Ionizer
Chungpung Co., Ltd.
Appliances > Heating, Cooling
and Air Health and Fitness >
Personal Care
Tourmaline Nano
Ceramic Curling Iron Bed
Head® Health and Fitness >
Personal Care
Tourmaline Nano
Ceramic Rotating 3-Barrel
Waver Bed Head® Health and
T|Studio - NanoSilver Dryer by Remington
Spectrum Brands Health and
Up Tight™
Firming Peptide Complex
Up Tight™
Firming Peptide Cream Kara
> Personal Care
Vidal Sassoon
Answers. 1" Nano Ceramic
Heated Flipper Styling Iron,
Coarse Hair Vidal Sassoon
Care Home and Garden >
NEW
Wrist Supporters
> Personal Care
Yes Ear Duhkha
Human Tech Health and
Vital Essence with
Arbutin Chantecaille Health
Care
Inventory of Sunscreen Products
Advanced
Protection SPF 30 Oil w/ Clear
Z COTE Zinc Skin Rx
Sunscreen
Applied Therapeutics™
Sunscreens Applied
Therapeutics™ Health and
Fitness > Sunscreen
All Day Suncare
SPF 15 Kara Vita Health
and Fitness > Sunscreen
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Nanotechnology Limited
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Patents in Nanotechnology-based Consumer Products
Inventory of Nanotechnology-based Consumer Products and Intellectual Property
Prepared by Formula Scan™ Research Associates
www.FormulaScan.com
March 07, 2010
After more than twenty years of exploratory and applied research, nanotechnologies are gaining popularity in
commercial use, largely due to the unique properties that nanoparticles are capable to impart to consumer
products. Nanoscale materials now are in electronic, cosmetics, automotive and medical products. But it has
been difficult to find out what countries and which Personal Care companies are actively pursuing
nanotechnology and how many nano-based consumer products are in the market and which merchandise could
be called “nano.”
Nanotechnology Patents Granted by Country: A worldwide survey of the patent activity related to use
and implementation of Nanotechnology in consumer products in the last 28 years, 1980 to 2009, conducted by
Formula Scan, http://www.formulascan.com, reveals that the countries of France and South Korea have been
granted the highest number of patents, closely followed by Germany, USA and Japan. The data in Figure 1
below indicates the predominance of these five countries whereas the rest of the world seems to lag far behind.
Figure 1
Nanotechnology Patents Granted by Company: The same survey of the patent activity related to use
and implementation of Nanotechnology in consumer products in the last 28 years, 1980 to 2009, conducted by
Formula Scan, http://www.formulascan.com, reveals that L'Oreal is by far the most active company in
nanotechnology, see chart below. L'Oreal's technology coverage seems to range broadly from patents in hair
care, skin care and sun care. A closer inspection of the patents granted to L'Oreal discloses that in Hair Care the
company has placed significant emphasis in the use of nanoparticles and nanoemulsions as delivery vehicles for
ingredients to promote hair growth or delay hair loss, for actives to promote follicular pigmentation of hair and
to prevent the formation of white or gray hair, for particles to reinforce hair styling polymers thus obtaining
longer hair style duration and for sunscreens to improve sun protection and photostability. L'Oreal seems to
make use of nanotechnology to deliver a number of new and conventional molecules, pigments and inorganic
sunscreen agents such as TiO2. In Skin and Sun Care the range of patents granted to L'Oreal cover technologies
including the use of nanoparticles to deliver a plurality of skin care actives to combat skin aging, stimulating
hair growth, inhibiting cellular proliferation or differentiation, prevent skin depigmentation, deliver sunscreen
particles or nanocapsules to enhance SPF and increase UVB and UVA protection, and stabilize chemically
sensitive active molecules thereby increasing their shelf life.
The data in Figure 2 below also indicates that a number of companies seem to be actively pursuing
nanotechnology but that the number of patents granted to these companies is far below the number of patents
granted to L'Oreal.
Figure 2
US PATENTS IN NANOTECHNOLOGY FOR HAIR CARE
GRANTED FROM 1980 TO 2008
Visit www.formulascan.com to review the complete patent document
US Patent No: 5932194
UV-Photoprotective cosmetic compositions comprising polymer particulates/fatty phases having unique
refractive indices
Topically applicable cosmetic/dermatological composition well suited for improved
photoprotection of human keratinous substrates, for example human skin and/or hair, comprise (a)
an aqueous phase, (b) at least one fatty phase having a refractive index n.sub.1, (c) an effective UVphotoprotecting amount of at least one water-soluble UV-screening active agent, and (d)
particulates of at least one non-film- forming polymer having a refractive index n.sub.2, and the
refractive indices n.sub.1, and n.sub.2 being selected such that:
Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural
formula (I): ##STR1## in which Ar is a radical selected from among those of the following
formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states,
whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular
and ophthalmological disorders, as well as for the treatment of mammalian skin and hair
conditions/disorders.
Screening cosmetic composition comprising one nanopigment of metallic oxide and one fat-soluble
screening polymer
The present invention is directed to a composition for screening out ultraviolet radiation,
comprising, in association, at least one nanopigment of metallic oxide and at least one UVscreening fat-soluble polymer.
Process for the dispersion by high-pressure homogenization of pulverulent fillers in a vehicle composed of
at least one fatty phase, compositions obtained and uses
The present invention relates to a process for the dispersion of at least one pulverulent organic filler
and/or of at least one pulverulent inorganic filler in a vehicle composed of at least one fatty phase,
by mixing the filler or fillers in the vehicle by high-pressure homogenization in one or a number of
passes, to the cosmetic or dermatological compositions capable of being obtained by this process.
The present invention also relates to the use of the compositions obtained by this process as the
basis for care, make-up and/or hygiene products. The present invention also relates to the use of the
compositions obtained by this process as the basis for products for protecting the skin, hair, scalp,
nails, eyelashes, eyebrows and/or mucous membranes against the effects of ultraviolet radiation.
Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation
Pigmentation of the skin, hair and/or nails of individuals is promoted by administering thereto,
advantageously topically and advantageously in combination with enzymes exhibiting tyrosinase
activity, effective pigmentation-promoting amounts of at least one retinoid compound which
comprises a phenolic or naphtholic functional group.
UV-photoprotective dibenzoylmethane compositions comprising photostabilizing amounts of
benzalmalonate silanes
Topically applicable, stable, UV-photoprotective cosmetic/dermatological compositions well suited
for the photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B
irradiation, comprise (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane
UV-sunscreen compound and (b) an effective dibenzoylmethane compound (a) photostabilizing
amount of at least one benzalmalonate silane having the structural formula (I): ##STR1##
Adamantyl-substituted retinoids and pharmaceutical/cosmetic compositions comprised thereof
Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural
formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and
are useful for the treatment of disorders and/or ailments manifesting an overregulation of RAR
receptors and/or a hypervitaminosis A.
Personal care compositions
Disclosed are personal care compositions which are suitable for application to the hair, skin, or
nails. These compositions comprise a polyorganosiloxane emulsion comprising a surfactant and a
polyorganosiloxane having an average particle size of less than about 150 nanometers; from about
0.01% to about 10% of a silicone-linear polyoxyalkylene block copolymer surfactant; and a carrier
comprising (i) at least about 0.5%, by weight of the composition, of a first solvent selected from the
group consisting of water, water soluble organic solvents, organic solvents which are strongly to
moderately strong in hydrogen-bonding parameter, and mixtures thereof, wherein the solvent is
other than a C.sub.1 -C.sub.3 monohydric alcohol, a C.sub.1 -C.sub.3 ketone, and a C.sub.1 C.sub.3 ether, and (ii) at least about 40%, by weight of the composition, of a second solvent
selected from the group consisting of C.sub.1 -C.sub.3 monohydric alcohols, C.sub.1 -C.sub.3
ketones, C.sub.1 -C.sub.3 ethers, and mixtures thereof. The silicone-polyoxyalkylene copolymer
surfactant provides for improved stability of the polyorganosiloxane emulsion, especially when
lower alcohols such as C.sub.1 -C.sub.3 monohydric alcohols are incorporated into the
compositions.
Pulsed filament lamp for dermatological treatment
A high energy filament lamp light source, such as a quartz tungsten halogen lamp, operated in a
pulsed mode with a high voltage input, creates a particular energy output. Applications of such
apparatus and methods include treatment of the dermis and/or sub-epidermal tissues for the purpose
of skin recontouring, thermal destruction of hair follicles for the purpose of hair removal, and
others, and a method which selectively preheats a subsurface region in targeted tissue to subThis document was prepared by www.FormulaScan.com. Its reproduction in any type of form or format is strictly prohibited without
thermal modification threshold values without significant heat damage to surrounding layers prior
to further treatment.
Photoprotective/cosmetic compositions comprising synergistic admixture of sunscreen compounds
Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of
human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly
solar radiation, comprise a photoprotecting synergistically effective amount of (i) 2,4,6-tris[p-((2'ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) 2-ethylhexyl .alpha.-cyano-.beta.,.beta.diphenylacrylate, in a cosmetically acceptable vehicle, diluent or carrier therefor.
Relatively high VOC hair styling compositions which provide good style retention without
unacceptable stickiness or stiffness are disclosed. The compositions comprise from about 0.01% to
about 20% of a hair styling polymer and a carrier comprising at least about 0.5%, by weight of the
composition, of a first solvent selected from the group consisting of water; water soluble organic
solvents; organic solvents which are strongly to moderately strong in hydrogen-bonding parameter;
and mixtures thereof; wherein the first solvent is other than a C.sub.1 -C.sub.3 monohydric alcohol,
a C.sub.1 --C.sub.3 ketone and a C.sub.1 -C.sub.3 ether, wherein the composition is characterized
by a FFV and a CRI wherein (FFV.sup.-1 .times.1000).gtoreq.[(-2.635.times.CRI)+36.418].
The present invention relates to personal care compositions suitable for styling hair, comprising
from about 0.01% to about 20% of a hair styling polymer, a polyorganosiloxane emulsion
comprising a polyorganosiloxane dispersed as particles an average particle size of less than about
150 nanometers, and a surfactant system; from about 0.01% to about 10% of a siliconepolyoxyalkylene copolymer surfactant and a carrier comprising at least about 0.5% of a first
solvent selected from the group consisting of water; water soluble organic solvents; organic
solvents which are strongly to moderately strong in hydrogen-bonding parameter; and mixtures
thereof; wherein the first solvent is other than a C.sub.1 -C.sub.3 monohydric alcohol, a C.sub.1 C.sub.3 ketone and a C.sub.1 -C.sub.3 ether.
Disclosed are personal care compositions, especially hair styling compositions, containing silicone
microemulsions, and corresponding applications of such compositions. The disclosed invention
further relates to stable, hair styling compositions containing a silicone microemulsion and lower
monohydric alcohol. A preferred personal care composition comprises from about 0.01% to about
20% of a non-silicone containing polymer suitable for hair styling; an organopolysiloxane
microemulsion comprising an organopolysiloxane dispersed as particles in the microemulsion
having an average particle size of less than about 80 nanometers, and a surfactant system which is
compatible with the hair styling polymer; and a carrier comprising from about 3% to about 99% of
a first solvent selected from the group consisting of water; water soluble organic solvents; organic
solvents which are strongly to moderately strong in hydrogen-bonding parameter; and mixtures
thereof; wherein the first solvent is other than C.sub.1 -C.sub.3 monohydric alcohol, C.sub.1 C.sub.3 ketone and C.sub.1 -C.sub.3 ether, and optionally, from about 0% to about 55% of a second
solvent selected from the group consisting of C.sub.1 -C.sub.3 monohydric alcohols, C.sub.1 C.sub.3 ketones, C.sub.1 -C.sub.3 ethers, and mixtures thereof.
Photoprotective/cosmetic compositions comprising UV-sunscreens/dialkyl tartrates
Novel cosmetic/dermatological UV-photoprotective compositions well suited for enhanced PF
photoprotection of human skin and/or hair comprise (a) an effective UV-screening amount of at
least one benzylidenecamphor sunscreen compound, and/or at least one dibenzoylmethane
sunscreen compound, and/or at least one triazine sunscreen compound, and (b) a PF-enhancing
amount of at least one dialkyl tartrate, formulated into a topically applicable,
cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.
Relatively low VOC hair styling compositions which provide good style retention without
unacceptable stickiness or stiffness are disclosed. The compositions comprise from about 0.01% to
about 20%, by weight of the composition, of a hair styling polymer; and a carrier comprising at
least about 0.5% to about 99.9%, by weight of the composition, of a first solvent selected from the
group consisting of water; water soluble organic solvents; organic solvents which are strongly to
moderately strong in hydrogen bonding parameter; and mixtures thereof; wherein the first solvent
is other than C1-C3 monohydric alcohol, C1-C3 ketone, and C1-C3 ether; and from about 0% to
about 55%, by weight of the composition, of a second solvent selected from the group consisting of
C1-C3 monohydric alcohols, C1-C3 ketones, C1-C3 ethers, and mixtures thereof; wherein the
composition is characterized by having a Stiffness Value (SV) and a Curl Retention Index (CRI),
wherein SV.gtoreq.[(0.703.times.CRI)-0.425)].
Composition for protecting the skin or the hair, containing nanopigments and a solid elastomeric
polyorganosiloxane combined with a fatty phase
A composition for topical application containing nanopigments and a solid elastomeric
polyorganosiloxane combined with a fatty phase, in order to improve the protection factor provided
by the nanopigments and stabilize the composition.
Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural
formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and
are useful for the treatment of a wide variety of disease states, whether human or veterinary, for
example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as
well as for the treatment of mammalian skin and hair conditions/disorders.
Method of hair removal by transcutaneous application of laser light
A method of hair removal, used primarily for cosmetic purposes, comprising the transcutaneous use
of laser light having a wavelength which targets the sebum found in the follicle and coating the
hair, heating the sebum which transfer heat first to the hair and hair root and then to the papilla and
papillary blood vessels via conduction, thus destroying the hair by photothermolysis while avoiding
significant damage to surrounding skin or tissue.
Skin treatment process using laser
The present invention provides a very simple easily administered skin treatment process for (1) the
removal of superficial epidermal skin cells in the human skin (2) the reduction or removal of
unwanted hair and (3) the mitigation of skin conditions such as acne and seborrhea. A contaminant
having a high absorption at at least one wavelength of light is topically applied to a section of the
surface of the skin. A preferred contaminant is a mixture of 20% by weight of one micron graphite
particles in mineral oil. Graphite is a very strong absorber of 1.06 micron light produced by the
Nd:YAG laser. Portions of the contaminant are forced to infiltrate into spaces between the
superficial epidermal cells, into hair ducts in the skin and into and/or adjacent to sebaceous glands.
The skin section is illuminated with short laser pulses at the matching wavelength, so as to impact
sufficient energy to the contaminant to cause explosion in the contaminant. The energy released in
the course of the explosions may blow off layers of dead skin cells and/or destroy tissue responsible
for hair growth and/or sebum production.
Light-screening agents
The invention relates to a composition which comprises a dibenzoylmethane capable of absorbing
UV-A radiation and a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 are
independently hydrogen, alkyl or alkoxy containing 1 to 18 carbon atoms provided that R.sup.1 and
R.sup.2 are not both hydrogen; and n is 1 or 2 in an amount effective to photostabilize the
dibenzolymethane, and a cosmetically acceptable carrier, and to cosmetic light-screening
compositions containing at least one of the above agents, the use of the cosmetic light-screening
compositions for the protection of the human skin and human hair against the ultraviolet radiation
of wavelengths between about 320 and 400 nm (UV-A) and optionally also between about 290 and
400 nm (UV-B).
Stable w/o photoprotective cosmetic emulsions
Stable, water-resistant photoprotective water-in-oil cosmetic emulsions, well suited for the
photoprotection of human skin and/or hair against the deleterious effects of UV irradiation,
comprise an effective stabilizing/emulsifying amount of a pair of active emulsifying agents, said
emulsifying agent pair comprising (i) at least one polyalkylpolyethersiloxane emulsifier substituted
by polyoxyethylene and polyoxypropylene moieties grafted onto the backbone polymer thereof,
and (ii) at least one water-in-oil emulsifying polyoxyalkylenated glycol fatty acid ester polymer.
Polyaromatic amide compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic amides have the structural formula (I):
##STR1## wherein Z is a radical --CO--NH-- or --NH--CO--,and are useful for the treatment of a
wide variety of disease states, whether human or veterinary, for example dermatological,
rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment
of mammalian skin and hair conditions/disorders.
Photoprotective cosmetic compositions containing a metal oxide nanopigment and an acrylic terpolymer,
and use of these compositions for protecting keratinous material against ultraviolet radiation
The present application relates to photoprotective cosmetic compositions containing at least one
metal oxide nanopigment and an acrylic terpolymer, as well as to the use of these compositions to
protect the skin, the hair, the eyelashes, the eyebrows or mucous membranes against ultraviolet
radiation. The acrylic terpolymer comprises: a) about 20 to 70% by weight of a carboxylic acid
containing .alpha., .beta.-monoethylenic unsaturation, b) about 20 to 80% by weight of a nonsurfactant monomer containing monoethylenic unsaturation, which is different from a), and c)
about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a
monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation.
The metal oxide nanopigments are chosen in particular from coated or uncoated titanium, cerium,
zirconium, iron and zinc oxide nanopigments, or mixtures thereof, and have an elementary particle
size of greater than 5 nm and less than 100 nm.
Hair removal using a contaminant matched to a laser
A device and process for the permanent removal of unwanted human hair. Hair on a section of skin
is contaminated with a substance having high absorption of a frequency band of light. The skin is
illuminated with light at this frequency band at sufficient intensity and duration to kill the follicles
or the skin tissue feeding the hair. One embodiment to produce death of the follicles or the skin
tissues feeding the hair is by photochemical reaction.
Cosmetic or dermatological composition comprising an oil-in-water emulsion comprising oily globules
with a lamellar liquid crystal coating
The present invention relates to a cosmetic or dermatological composition comprising an emulsion
of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal
coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic
compound which is cosmetically or dermatologically active is individually coated with a
monolamellar or oligolamellar layer obtained from at least one lipophilic surface-active agent, from
at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting
to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of
less than 500 nanometers.
Photostable sunscreen compositions comprising dibenzoylmethane compounds and 2hydroxybenzophenone-substituted silanes/organosiloxanes
Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well
suited for the photoprotection of human skin and/or hair against the damaging effects of UVirradiation, particularly solar radiation, comprise (1) a UV-photoprotecting effective amount of at
least one dibenzoylmethane sunscreen compound and (2) a photostabilizing effective amount of at
least one silane or organosiloxane bearing a 2-hydroxybenzophenone substituent.
Silicone-substituted cinnamamide/malonamide/malonate compounds and photoprotective compositions
comprised thereof
Novel silicone-substituted cinnamamide/malonamide/malonate compounds having the structural
formulae (1) and (2): ##STR1## in which A is a radical of formula (3): ##STR2## are well suited
irradiation, particularly solar radiation, and are also useful for photoprotecting such UV-sensitive
substrates as plastics.
Emulsion compositions, suitable for personal care applications such as hair styling, and other
applications, are disclosed. The compositions comprise: a) a silicone functional polymer having the
formula selected from the group consisting of: (AB).sub.n ; ABA; BAB; ##STR1## and mixtures
thereof; wherein B is a silicone moiety comprising repeating units of: ##STR2## R is
independently, C1-C30 alkyl, aryl, alkylaryl, haloalkyl, H, or C1-C6 alkoxy, wherein the weight
average molecular weight of each silicone moiety B is independently from about 1500 to about
50,000; A is a polar polymeric moiety which is soluble or dispersible in mixtures of ethanol and
water containing less than 60% ethanol by weight; and n is an integer of 1 or greater; wherein the
molecular weight of the silicone functional polymer is at least about 2,000. b) an
organopolysiloxane emulsion comprising: (i) a polyorganosiloxane dispersed as particles in the
emulsion, the polyorganosiloxane having an average particle size of less than about 150
nanometers, and (ii) a surfactant system for dispersing the organopolysiloxane in the emulsion; c) a
carrier comprising at least about 0.5%, by weight of the composition, of a first solvent selected
from the group consisting of water; water soluble organic solvents; organic solvents which are
strongly to moderately strong in hydrogen-bonding parameter; and mixtures thereof; wherein the
first solvent is other than C.sub.1 -C.sub.3 monohydric alcohol, C.sub.1 -C.sub.3 ketone and
C.sub.1 -C.sub.3 ether; wherein the silicone functional polymer is present in an amount effective to
stabilize the emulsion in the personal care composition.
Photoprotective/cosmetic compositions comprising 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5triazine and salicylate solvents therefor
solar radiation, comprise (i) a photoprotecting effective amount of 2,4,6-tris[p-((2'ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) at least one homomenthyl and/or octyl
salicylate solvent for the triazine sunscreen compound (i), in a cosmetically acceptable vehicle,
diluent or carrier therefor.
Personal cleansing compositions providing improved hair and skin conditioning
The compositions of the present invention relate to improved personal cleansing compositions
comprising a surfactant system, from above about 0.1% to below 1% of a nonionic or anionic water
soluble polymer, a phase separation initiator and water. These compositions provide improved
lathering and conditioning benefits.
Photoprotective/cosmetic compositions comprising benzotriazole-substituted silicon compounds and
benzoic triacid triesters
Topically applicable cosmetic/dermatological sunscreen compositions well suited for the UVphotoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B
irradiation, particularly solar radiation, comprise (i) a UV-photoprotecting effective amount of at
least one solubilized organolipophilic silicon compound, whether silane or organopolysiloxane,
bearing a benzotriazole function substituent and (ii) an amount of at least one benzoic triacid
triester effective to (substantially) dissolve said at least one organolipophilic silicon compound.
comprised thereof
Stable oil-in-water emulsion, process for its manufacture and its use in the cosmetic and dermatological
fields
A fine and stable emulsion of an oily phase in an aqueous phase containing ionic polymer particles,
the oil globules of the emulsion having a mean size of at most 500 nm, a process for the
stabilization of fluid emulsions, a process for the preparation of these emulsions and their use in the
cosmetic and dermatological fields and more particularly as composition for anti-sun protection.
Photoprotective/cosmetic compositions comprising benzotriazole-substituted silicon sunscreens and
cinnamic/salicylic acid solubilizing agents therefor
least one solubilized organolipophilic silicon compound, whether solid silane or
organopolysiloxane, bearing a benzotriazole function substituent and (ii) an amount of at least one
cinnamic acid sunscreen compound and/or at least one salicylic acid sunscreen compound effective
to (substantially) dissolve said at least one organolipophilic silicon compound.
Photobluing/whitening-resistant cosmetic/dermatological compositions comprising TiO.sub.2 pigments
and deformable hollow particulates
Topically applicable cosmetic/sunscreen/dermatological compositions, well suited for improved
photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B
irradiation and/or for the therapeutic treatment of a disease state of the skin or mucosae, essentially
in the absence of photobluing/whitening, comprise at least one titanium dioxide (nano)pigment and
an effective photobluing/whitening-reducing amount of deformable hollow particulates
(microspheres) having a particle size ranging from 1 .mu.m to 250 .mu.m and which comprise an
expanded copolymer of vinylidene chloride, acrylonitrile and a (meth)acrylate.
Hair styling compositions containing silicone microemulsions and cationic non-polymeric liquids
Disclosed are hair styling compositions comprising from about 0.01% to about 20% of a nonsilicone-containing hair styling polymer; from about 0.1% to about 20% of a liquid hydrophilic
non-polymeric cationic compound having at least one quaternary ammonium moiety; from about
3% to about 99% of selected carriers; and an organopolysiloxane microemulsion that contains a
dispersing surfactant and from about 0.01% to about 10% organopolysiloxane (by weight of the
composition), wherein the organopolysiloxane is substantially free of amino groups in combination
with hydroxyl groups and the microemulsion has an average particle size of less than about 80 nm.
The composition provides good style retention, restyling benefits, and improved hair aesthetics, e.g.
blacker/shinier hair, less sticky/stiff.
Triaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I):
##STR1## and are useful for the treatment of a wide variety of disease states, whether human or
veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and
ophthalmological disorders, as well as for the treatment of mammalian skin and hair
Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural
formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether
human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and
Photoprotective/cosmetic compositions comprising camphorsulfonic acid and bisresorcinyltriazine
sunscreens
Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced
photoprotection of human skin and/or hair against the damaging effects of UV-irradiation,
particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each
of (i) benzene-1,4-di(3-methylidene-10-camphorsulfonic acid, or partially or completely
neutralized form thereof, and (ii) at least one bisresorcinyltriazine compound, formulated into a
topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.
Detergent cosmetic compositions and use thereof comprising an aminosilicone and a cationic polymer
Novel detergent compositions comprising, in a cosmetically acceptable medium, (A) a washing
base comprising at least one ether sulphate anionic surfactant and at least one surfactant of
alkylbetaine type, and (B) a conditioning system comprising at least one cationic polymer,
preferably dimethyldiallylammonium, and at least one aminosilicone, and uses thereof.
Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural
formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide
variety of disease states, whether human or veterinary, for example dermatological, rheumatic,
respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of
mammalian skin and hair conditions/disorders.
Synergistically UV-photoprotecting triazine/silicone compositions
The invention relates to novel cosmetic and/or dermatological compositions, in particular for
photoprotecting the skin and/or the hair, characterized in that they comprise, in a cosmetically
acceptable support in particular of oil-in-water type, (i) as first screening agent, at least one specific
1,3,5-triazine derivative, and (ii) as second screening agent, a silicon derivative containing a
benzotriazole function, the said first and second screening agents being present in the said
compositions in an amount which is effective for producing synergistic activity with respect to the
sun protection factors imparted. Application to protecting the skin and the hair against the effects of
ultraviolet radiation.
Bioaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof
Photoprotective/cosmetic compositions comprising w/o/w stable triple emulsions
The present invention relates to a cosmetic or dermatological emulsion of the water/oil/water
(W/O/W) type, characterized in that it comprises: (a) an external aqueous phase and (b) a noncontinuous fatty phase constituting, with an internal aqueous phase, a water/oil (W/O) primary
emulsion, the said fatty phase comprising, as lipophilic emulsifier, at least one block copolymer
composed of a polymer block derived from a monohydroxycarboxylic acid and of a polymer block
derived from an alkylglycol or from a polyalkylene glycol; (c) at least one photoprotective system
capable of screening out UV (UV-A and/or UV-B) radiation. The invention also relates to its uses
in and for the manufacture of cosmetic or dermatological compositions for the photoprotection of
the skin or hair.
screening polymer
Apparatus and method for removing hair
An apparatus and method for removing hairs from a region of skin, the apparatus including: a
housing having an opening therein, the housing forming a cavity enclosing a volume of air when
the opening is placed in contact with the region of skin; a switchable heat source disposed within
the housing that rapidly heats the volume of air to a temperature sufficient to destroy the hair by
conduction of heat along the length of the hair to a follicle thereof; and a power source that
controllably energizes the heat source.
Photostabilized sunscreen compositions comprising dibenzoylmethane compounds
suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UVA and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective
amount of at least one dibenzoylmethane UV-screening compound, and (ii) an amount of at least
one silane or organosiloxane substituted by a benzylidenecamphor functional group effective to
photostabilize said at least one dibenzoylmethane UV-screening compound (i).
Systems and methods for the multispectral imaging and characterization of skin tissue
Systems and methods for the multispectral imaging of skin tissue enables automatic
characterization of the condition of a region of interest of the skin, based on direct digital imaging
of the region of interest or the digitization of color photographic slides of the region of interest,
illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is
automatically segmented and that segmented mask is used to segment the other images by a digital
processor. Parameters related to the texture, asymmetry, blotchiness and border irregularities are
also automatically estimated. The region of interest is automatically characterized by the digital
processor, based on those parameters. The region of interest may include a skin lesion, in which
case the present invention enables the characterization of the lesion as malignant or benign.
Photoprotective/cosmetic compositions comprising camphorsulfonic acid, bisresorcinyltriazine and
benzoazolyl/benzodiazolyl sunscreens
of (a) benzene-1,4-bis(3-methylidene-10-camphorsulfonic acid), optionally in neutralized form
thereof, (b) at least one bisresorcinyltriazine compound, and (c) at least one compound containing
at least two benzoazolyl groups or at least one benzodiazolyl group, formulated into a topically
applicable, cosmetically acceptable vehicle, diluent or carrier therefor.
Photoprotective/cosmetic compositions comprising benzotriazole and benzoazolyl/benzodiazolyl
sunscreens
of (a) at least one benzotriazole compound, and (b) at least one compound containing at least two
benzoazolyl groups and/or at least one benzodiazolyl group, formulated into a topically applicable,
cosmetically acceptable vehicle, diluent or carrier therefore.
Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised
thereof
Novel liposoluble and photostable N-substituted benzimidazole/benzofuryl-benzazole siliconcontaining compounds are conspicuously excellent UV-absorbers and are conveniently formulated,
e.g., into topically applicable sunscreen/cosmetic compositions well suited for the UVphotoprotection of human skin and/or hair.
formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(d): ##STR2## and
are useful for the treatment of disorders and/or ailments manifesting an overregulation of PAR
Method of depigmenting and/or bleaching skin and/or body hair or head hair
The use, in a topical cosmetic composition, or for the manufacture of a topical dermatological
composition, intended for depigmenting and/or bleaching human skin, body hair or head hair, of at
least one compound comprising a phenyloxime fragment.
Photoprotective/cosmetic compositions comprising bisresorcinyltriazine and benzoazolyl/benzodiazolyl
of (a) at least one bisresorcinyltriazine compound, and (b) at least one compound containing two
benzoazolyl groups, or at least one benzodiazolyl group, formulated into a topically applicable,
cosmetically acceptable vehicle, diluent or carrier therefor.
Photoprotective/cosmetic compositions comprising benzotriazole, bisresorcinyltriazine and
particularly solar ratiation, comprise synergistically UV-photoprotecting effective amounts of each
of (a) at least one benzotriazole compound, (b) at least one bisresorcinyltriazine compound and (c)
at least one compound containing at least two benzoazolyl groups per molecule and/or at least one
compound containing, per molecule, at least one benzodiazolyl group, formulated into a topically
Method of hair depilation
A method of hair depilation using an Nd:YAG laser which causes local heating at the hair bulb due
to the absorption of the oxyhemoglobin contained in the capillaries. The Nd:YAG laser operates at
1060 nanometers. Each pulse is a special pulse having a first portion and a second portion, where
power output in the first portion is 20 times greater than power output in the second portion. That
way, the first portion of each pulse is used to quickly heat up the tissue to a damaging temperature,
and the second portion maintains that temperature to cause hair removal for the tissue.
Hair removal device and method
or the skin tissue feeding of the hair. Specific embodiments to produce death of the follicles or the
skin tissues feeding the hair by heating and by photochemical reaction.
Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological,
pharmaceutical, and/or ophthalmological fields
The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an
aqueous phase; and at least one anionic surfactant selected from the group including phosphoric
acid fatty esters and oxyethylenated derivatives thereof, and mixtures thereof; wherein the oily
phase includes oil globules having a number-average size of less than 100 nm; wherein the oily
phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight
ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process
for making the nanoemulsion, and methods for its use. The nanoemulsion is ideally transparent and
stable on storage. It can ideally contain large amounts of oil while retaining good transparency and
good cosmetic properties. The nanoemulsion is particularly useful in compositions, including
topical, pharmaceutical, dermatological, cosmetic, opthalmic, and opthalmologic. The composition
is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.
Depilation
Mammalian hair is depilated using a laser source capable of emitting pulse radiation, each pulse
having a duration of 1 microsecond to 1 millisecond, and having a wavelength in the range of 600
to 1500 nanometers. The radiation exposure dose is preferably between 2 and 25 J/cm.sup.2. A
selected area of a subject's skin is irradiated by the pulsed radiation, the area having a plurality of
irradiation zones. The laser source is successively pulsed so as to irradiate successive zones of the
treatment area with the radiation, so as to destroy subdermal biological material associated with
hair growth.
Photoprotective/cosmetic compositions comprising bis-hydroxyphenylbenzotriazole and
benzazolyl/benzodiazolyl sunscreens
Topically applicable sunscreen/cosmetic compositions well suited for the SPF synergistically
enhanced photoprotection of human skin and/or hair against the damaging effects of UVirradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective
amounts of each of (a) at least one bis-hydroxyphenylbenzotriazole sunscreen compound and (b) at
least one second sunscreen compound which comprises at least two benzazolyl functional groups
per molecule and/or at least one sunscreen compound which comprises at least one benzodiazolyl
functional group per molecule, formulated into a topically applicable, cosmetically acceptable
vehicle, diluent or carrier therefor, advantageously formulated as an oil-in-water emulsion.
Photostabilized sunscreen compositions comprising dibenzoylmethane compounds and
benzylidenecamphor-substituted silanes/organosiloxanes
Use of nanoscale sterols and sterol esters
A composition containing an effective amount of nanoparticles selected from the group consisting
of nanoscale sterols, nanoscale sterol esters, and mixtures thereof.
Use of an indigoid compound in a cosmetic composition, in particular a make-up composition, in order to
confer on it antimicrobial properties and the property of lengthy hold over time
The invention relates to the use of at least one compound of formula: ##STR1## in which R.sub.1
and R'.sub.1 are C.sub.1 -C.sub.18 alkyl radicals which are optionally substituted by one or more
halogens or hydroxyls and/or are interrupted by one or more heteroatoms, and R.sub.2 to R.sub.5
and R'.sub.2 to R'.sub.5 are hydrogen or halogen atoms, hydroxyl radicals or C.sub.1 -C.sub.6
alkyl, alkyloxy, acyl or acyloxy radicals, in a cosmetic composition, in particular a make-up
composition, in order to confer on it antimicrobial properties and properties of lengthy hold over
time and/or of non-migration and/or of freedom from transfer and/or of non-formation of streaks.
The invention also relates to a cosmetic composition, in particular a make-up composition and
especially an eyeshadow, comprising such a compound in a silicone binder.
Nanoemulsion based on oxyethylenated or non-oxyethylenated sorbitan fatty esters, and its uses in the
cosmetics, dermatological and/or ophthalmological fields
The present invention relates to a nanoemulsion, the oil globules of which have an average size of
less than 100 nm, comprising (1) a surfactant which is solid at a temperature of less than or equal to
45.degree. C., which surfactant is chosen from sorbitan fatty esters and oxyethylenated sorbitan
fatty esters, (2) at least one oil having a molecular weight of greater than 400 and (3) at least one
ionic amphiphilic lipid chosen from the group formed by the alkaline salts of dicetyl and dimyristyl
phosphate, the alkaline salts of cholesterol sulphate, the alkaline salts of cholesterol phosphate,
lipoamino acids, the sodium salts of phosphatidic acid, cationic amphiphilic lipids and alkylsulfonic
derivatives, the ratio by weight of the amount of oily phase to the amount of surfactant ranging
from 2 to 10. The surfactant used is, for example, chosen from sorbitan monostearate, sorbitan
monopalmitate and sorbitan 20 EO tristearate. The emulsion obtained is transparent and stable on
storage. It can comprise large amounts of oil while retaining good transparency and while having
good cosmetic properties. The invention also relates to the use of the nanoemulsion according to
the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin
and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an
eye lotion for treating the eyes.
Oil-in-water emulsions containing a 1,3,5-triazine derivative and a copolyol silicone and cosmetic
applications
The present application relates to novel oil-in-water emulsions comprising i) at least one specific
1,3,5-triazine derivative and ii) at least one polyalkyl-polyethersiloxane carrying polyoxyalkylene
groups grafted onto the main silicone chain; with the proviso that the said emulsions do not
comprise cetylstearyltrimethylammonium chloride. Another subject-matter of the present invention
is the use of such emulsions in the manufacture of cosmetic or dermatological compositions
intended for the photoprotection of the skin and/or hair and/or other keratinous substances against
ultraviolet radiation, in particular solar radiation.
Combination of a retinoid with a polyamine polymer
A composition comprising the combination of at least one retinoid selected from the group
consisting of vitamin A (retinol) and the bioconvertible precursors of vitamin A and at least one
polyamine polymer.
Combination of a retinoid with a histidine derivative
A composition containing at least one retinoid and at least one histidine derivative. The histidine
derivative improves the stability of the retinoid in the composition. The composition may be used
to treat skin and/or hair.
UV-photoprotecting sunscreen compositions comprising immixture of polyethylene/carboxylated
polyethylene polymers
Topically applying cosmetic/dermatological compositions well suited for both effective and SPFenhanced UV-photoprotection of human skin and/or hair contain (a) an effective UVphotoprotecting amount of at least one UV-A and/or UV-B sunscreen and (b) an amount of
immixture of ethylene polymers effective to enhance the SPF value of said at least one UV-A
and/or UV-B sunscreen (a), said immixture of ethylene polymers (b) comprising (i) at least one
carboxylated polyethylene and (ii) at least one polyethylene, formulated into a topically applicable,
cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor, advantageously
formulated as an oil-in-water emulsion.
Photoprotective cosmetic composition containing an anionic surfactant, compounds for screening out
ultraviolet radiation and a cationic or zwitterionic amphiphilic compound, and use thereof
The invention relates to a cosmetic composition, in particular for photoprotecting the skin and/or
the hair, in the form of a dispersion comprising two immiscible phases stabilized with at least one
anionic surfactant chosen from the salts of fatty acids and of monovalent or polyvalent metals, of
ammonium or of organic bases, a compound for screening out ultraviolet radiation, which can be
adsorbed at the interface of the said immiscible phases, derived from benzylidenecamphor and
comprising at least one partially or totally neutralized sulphonic acid function, a metal oxide
nanopigment coated with hydrophobic hydrocarbon-based coating agents and a cationic or
zwitterionic amphiphilic compound which leads, with the anionic surfactant, to the formation of a
compound capable of lowering the water/liquid paraffin interface tension at 40.degree. C. by more
than 14 mN.m.sup.-1 for an anionic surfactant concentration of 0.1 mmol/100 g, by more than 26
mN.m.sup.-1 for an anionic surfactant concentration of 0.5 mmol/100 g and by more than 33
mN.m.sup.-1 for an anionic surfactant concentration of 1 mmol/100 g.
Nanoemulsion based on ethoxylated fatty ethers or on ethoxylated fatty esters and its uses in the
aqueous phase; and at least one surfactant that is solid at a temperature of less than or equal to
45.degree. C. and which is selected from the group including ethoxylated fatty ethers and
ethoxylated fatty esters, and mixtures thereof; wherein the oily phase includes oil globules having a
number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a
molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant
ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and
methods for its use. The emulsion is ideally transparent and stable on storage. It can ideally contain
large amounts of oil while retaining good transparency and good cosmetic properties. The
nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, cosmetic,
opthalmic, ophthalmologic. The composition is also particularly useful in applications to the skin,
hair, scalp, mucous membranes, and eyes.
Photoprotective/cosmetic compositions comprising novel benz-x-azole-substituted silane/siloxane
sunscreens
Photoprotective, topically applicable sunscreen/cosmetic compositions well suited for the UVphotoprotection of human skin and/or hair, comprise an effective UV-photoprotecting amount of at
least one novel benz-x-azole-substituted silane or siloxane having the formula (1) or (2): ##STR1##
A--SiR'.sub.1 R'.sub.2 R'.sub.3 (2) in which A is a radical having the structural formula (I):
##STR2##
Photoprotective/cosmetic compositions comprising aminoamidine sunscreens
Topically applicable sunscreen/cosmetic compositions well suited for the photoprotection of human
skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation,
comprise an effective UV-photoprotecting amount of at least one characteristically novel
aminoamidine compound, advantageously having the structural formula (I): ##STR1## formulated
into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.
UV-photoprotecting W/O emulsions comprising micronized insoluble screening agents & nonscreening
oxyalkylenated silicones
Topically applicable, water-resistant cosmetic/dermatological water-in-oil (W/O) emulsions well
suited for the UV-photoprotection of human skin and/or hair comprise (a) at least one aqueous
phase and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one
micronized organic UV-screening agent insoluble therein, the mean particle size of such
micronized particles ranging from 0.01 to 2 .mu.m, and (d) at least one oxyalkylenated non-UVscreening organomodified silicone.
Cosmetic composition comprising a compound such as indigoid
A cosmetic composition comprising, in a cosmetically acceptable medium, at least one compound
of formula (I) ##STR1## in which R.sub.1, and R'.sub.1 are chosen from alkyl radicals and
R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, and R'.sub.5 are chosen from a
hydrogen atom, a halogenated radical, a hydroxyl radical, an alkyl, alkyloxy, acyl, or acyloxy
radical having 1 to 6 carbon atoms. The use of compounds of formula (I) for coating substrate
particles, the resulting powder substance, and its use in a cosmetic composition.
UV-photoprotecting emulsions comprising micronized insoluble screening agents and associative
polymers
Topically applicable, water-resistant cosmetic/dermatological emulsions well suited for the UVphotoprotection of human skin and/or hair contain an effective UV-photoprotecting amount of at
least one micronized organic UV-screening agent insoluble therein, the mean particle size of such
micronized particles ranging from 0.01 to 2 .mu.m, and further containing at least one associative
polymer which is characteristically other than a C.sub.8 -C.sub.16 alkyl polyglucoside.
Synergistically UV-photoprotecting benzotriazole-substituted silicon/cinnamic acid compositions
Topically applicable cosmetic/dermatological compositions suited for improvedly UVphotoprotecting human skin and/or hair against the deleterious effects of ultraviolet irradiation,
advantageously oil-in-water emulsions, contain SPF-synergistically enhancing amounts of (a) at
least one UV-screening benzotriazole-substituted silicon compound and (b) at least one UVscreening cinnamic acid derivative, formulated into (c) a topically applicable,
Nanoemulsion based on alkyl ether citrates and its uses in the cosmetics, dermatological, pharmacological
and/or ophthalmological fields
A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising an
anionic surfactant chosen from alkyl ether citrates and at least one oil having a molecular weight of
greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant
ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise
large amounts of oil while retaining good transparency and while having good cosmetic properties.
It can constitute a composition for topical use, a pharmaceutical composition or an
ophthalmological composition. The invention also relates to the use of the nanoemulsion according
to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin
Emulsifier-free UV-photoprotecting emulsions comprising micronized insoluble screening agents
Topically applicable, water-resistant but emulsifier-free cosmetic/dermatological emulsions well
suited for the UV-photoprotection of human skin and/or hair contain (a) at least one aqueous phase
and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one
micronized particles ranging from 0.01 to 2 .mu.m and (d) optionally, at least one crosslinked
polymer of at least one ethylenically unsaturated monomer.
Nanoemulsion based on mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of a
glycerol and its uses in the cosmetics, dermatological and/or ophthalmological fields
A nanoemulsion, the oil globules of which have a number-average size of less than 100 nm,
comprising a surfactant chosen from mixed esters of a fatty acid or of a fatty alcohol, of a
carboxylic acid and of glycerol and at least one oil having a molecular weight of greater than 400,
the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10.
The nanoemulsion may be used in, for example, the cosmetics and dermatological fields, in
particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and
in the ophthalmological field, as an eye lotion for treating the eyes.
Bioadhesive nanoparticulate compositions having cationic surface stabilizers
Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more
cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of
the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an
insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles
may consist of pharmacologically active compounds (e.g., drug compounds for human or
veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic
agents, consumer products (coloring agents, flavors, or fragrances), or other materials which
function by interacting with biological substrates. In addition, the invention relates to methods of
preparing and using such bioadhesive nanoparticulate compositions.
Device for the stimulation of body cells through electromagnetic radiation
The invented device for hair-care consists of an applicator (1), which is equipped with at least one
print-board (6,7), upon which semiconductor-diodes (LED) or laser-diodes (8) are placed. The
semiconductor-diodes (LED) and the laser-diodes radiate light with a wavelength between 350 and
1200 nm. Further, the applicator (1) contains one or more plain transmitter-coils (transducers) (3)
for the emission of pulse-shaped electromagnetic radiation. It can be equipped with an IR-heating
element and a ventilator to produce a warm air stream. The applicator (1) can be formed as a hood
(2) or designed as a plainer surface applicator consisting of one or more parts, in the latter case the
parts being connected with moveable joints. The applicator can also be designed as a hand
applicator. In this case it resembles an ordinary hand-held hair drier, consisting of an almost
cylindrical tube with a rectangular handle.
Nanoemulsion based on alkoxylated alkenyl succinates or alkoxylated alkenyl succinates of glucose and
its uses in the cosmetics, dermatological, opthalmological and/or pharmaceutical fields
A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a
surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of
glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a
molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount
of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It
can comprise large amounts of oil while retaining good transparency and while having good
cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition
or an ophthalmological composition.
Nanosecond gate spectroscopic diagnostic device
A diagnosis apparatus comprises a shutter (11) disposed between a light source (1) and a lens (12)
opposed to biological tissue (13); a multi-channel spectrometer (polychromator) (16) for detecting a
light emitting plume (14); a photodetector (5) for detecting a portion of a laser pulse from the light
source (1); an oscilloscope (6) which monitors an output from the photodetector (5) to thereby
measure a delay time of a gate trigger pulse supplied to a high-speed gate image intensifier (17); a
pulse generator (8) capable of independently and freely adjusting the delay times of two output
pulses in synchronization with the laser pulse; a gate controller (7) connected to the pulse generator
(8) and the oscilloscope (6); the high-speed gate image intensifier (17) intensifying and imaging the
output of the multi-channel spectrometer (16) whose gate is opened by the gate controller (7) over a
period on the order of nanosecond; a CCD camera (9) capturing an output image from the highspeed gate image intensifier (17); and a data-processing apparatus comprising a frame image data
storage (10A) which inputs spectroscopic image data of one frame from the CCD camera (9) as a
time-series analog signal, and converts the analog signal to a digital signal for transmission to a
computer (10).
Nanoemulsion based on ethylene oxide and propylene oxide block copolymers and its uses in the
A nanoemulsion comprising an oily phase dispersed in an aqueous phase and having oil globules
with a number-average size of less than 100 mm, which dispersion is facilitated by a surfactant
comprised of polyethylene oxide and polypropylene oxide blocks, the oily phase comprising at
least one oil having a molecular weight of greater than 400 and wherein the ratio by weight of the
amount of oily phase to the amount of surfactant ranges from 2 to 10.
Use in cosmetic compositions of amphoteric surface-active agents for precipitating cationic polymers in
the diluted state
The invention relates to the use of at least one amphoteric in transparent aqueous cosmetic
compositions for the hair and/or the skin designed to be rinsed, comprising at least one anionic
surface-active agent, at least one surface-active agent selected for the betaines and at least one
water-soluble or water dispersible cationic polymer derived from a polysaccharide (PolC), as
precipitant, in the diluted state, of said cationic polymer (PolC). The invention further relates to
transparent aqueous cosmetic compositions for the hair and/or skin designed to be rinsed,
comprising at least one one anionic surface-active agent, at least one surface-active agent selected
for the betaines, at least one water-soluble or water dispersible cationic polymer derived from a
polysaccharide (PolC), and at least one amphoteric surface-active agent.
Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of
the SOD in cosmetic, food and pharmaceutical compositions
The invention relates to a novel purified isozyme of an autoclavable superoxide dismutase
extracted from the plant Potentilla atrosanguinea Lodd. Var. orgyrophylla, said isozyme having the
following characteristics, O.sub.2.sup.- scavenging activity remains same before and after
autoclaving; scavenges O.sub.2.sup.- from sub-zero temperature of -20.degree. C. to high
temperature of +80.degree. C.; O.sub.2.sup.- scavenging activity at 25.degree. C. for 30 days
without adding any stabilizing agent such as polyols or sugars; O.sub.2.sup.- scavenging activity in
the presence of saline (0.9% sodium chloride) to 61.8% of the control (without 0.9% sodium
chloride), stable at 4.degree. C. for at least 8 months; contamination free and infection free from
any living micro- and/or macro-organism after autoclaving; possesses temperature optima at
0.degree. C.; possesses a molecular weight of 33 kD under non-denaturating conditions; possesses a
molecular weight of 36 kD under denaturating conditions; has clear peaks in UV range at 268 and
275 nm; has an enzyme turnover number of 19.53.times.10.sup.4 % per nmol per min at 0.degree.
C.; and requires Cu/Zn as a co-factor, method for the preparation of the purified isozyme of
autoclavable superoxide dismutase and formulations containing the said autoclavable superoxide
dismutase.
Solubilization of 1,3,5-triazine derivatives with N-acyl amino acid esters
A composition comprising at least one 1,3,5-triazine derivative and at least one N-acyl amino acid
ester and its use in or for the manufacture of compositions, especially cosmetic and dermatological
compositions for protecting the skin and/or the lips and/or integuments against ultraviolet radiation,
in particular solar radiation. In addition, a cosmetic treatment process comprising the application of
the cosmetic composition, and the use of the at least one N-acyl amino acid ester, in anti-sun
compositions containing a 1,3,5-triazine derivative to improve the sun protection factor of the
composition.
(poly)thiaalkynoic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural
formula (I): and are useful for the treatment of a wide variety of disease states, whether human or
veterinary, for example inflammation disorders, as well as for the treatment of mammalian skin and
hair conditions/disorders.
Use of plant extracts with an anti-radical-type action
The use of plant extracts, especially plant extracts with an anti-radical-type action, and a cosmetic
or dermo-pharmaceutical composition containing extracts of this type. The use of at least one plant
extract whose botanical genus belongs to the group formed by the following: Clidemia, Inga,
Sabicea, Astrocaryum, Siparuna, Eperua, Byrsonima, Priva, Coutoubea and Goupia genera; as an
active substance which has especially anti-radical-type activities, for preparing a cosmetic or
dermopharmaceutical product for local, external use for the skin, the mucous membranes and/or the
epithel or appendage structures.
Aqueous dispersion of water-insoluble organic UV filter substances
The invention relates to aqueous dispersions of sparingly water-soluble or water-insoluble organic
UV filter substances, which comprise at least one sparingly water-soluble or water-insoluble
organic UV filter substance as colloidally disperse phase in amorphous or partially amorphous
form.
Nanoemulsion based on glycerol fatty esters, and its uses in the cosmetics, dermatological and/or
ophthalmological fields
aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less
than or equal to 45.degree. C.; wherein the oily phase includes oil globules having a numberaverage size of less than 100 nm; wherein the oily phase includes at least one oil having a
ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and
methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain
nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for
moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the
ophthalmological field, as an eye lotion for treating the eyes.
of laser light having a wavelength which targets the keratin components of hair, thus destroying the
hair by photothermolysis without damage to surrounding skin or tissue; this primary method may
be supplemented by the use of intrafollicular hair removal methods utilizing a second wavelength
of light produced by the same source used to generate the primary light wavelength.
Porous polymethylsilsesquioxane with adsorbent properties
The present application describes a porous polymethylsilsesquioxane (PMS) having a specific
surface area between approximately 50 m.sup.2 /g and 500 m.sup.2 /g, a pore volume between
approximately 0.1 cm.sup.3 /g and 0.8 cm.sup.3 /g, a monolayer volume between approximately 10
cm.sup.3 /g and 60 cm.sup.3 /g, a pore radius smaller than 1 nm for 90% of the pores and
insolubility in water and organic solvents. The PMS according to the invention is prepared by
precipitation of a polymethylsiliconate of the general formula ##STR1## in which n is a whole
number between approximately 20 and 100 and M is an alkaline metal or alkaline-earth metal or
NH.sub.4.sup.+.
Variable pulse duration, adjustable wavelength medical laser system
A medical laser system is disclosed for generating a pulsed output beam of variable pulse duration
and wavelength. The on time of the laser is the pulse duration which is generated by a Q-switch
operated in a repetitive mode as a train of micropulses. According to one embodiment, a
repetitively Q-switched frequency-doubled solid state laser produces an input beam which is
subsequently used to excite a dye laser. An excitation source of the solid state laser is modulated to
control the pulse duration of the input beam. The dye laser receives the input beam and
responsively generates an output beam of adjustable wavelength having a pulse duration
corresponding to the pulse duration of the input beam. The wavelength of the output beam is
controlled by adjusting a tuning element of the dye laser. The dye laser is coupleable to a delivery
system for directing the output laser beam to a biological tissue target. By carefully controlling the
pulse duration and wavelength of the beam delivered to the target tissue, a user of the laser system
may avoid or minimize damage to tissue adjacent to the target tissue.
Comixture of dextran sulfate/escin for treating skin redness/edema and/or sensitive skin
Comixtures of escin and dextran sulfate are effective for treating skin redness/edema and/or
sensitive skin, particularly redness and/or edema around the eyes and most particularly bags and/or
dark rings around the eyes.
Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one polyethylene
glycol (PEG) ester, and uses thereof
Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and
comprising at least one oil, at least one amphiphilc lipid, and at least one polyethylene glycol
(PEG) derivative chosen from PEG esters and PEG ethers chosen from compounds of formula (I):
in which: R.sub.1 is chosen from linear and branched, saturated and unsaturated alkyl groups
comprising from 8 to 30 carbon atoms and linear and branched, saturated and unsaturated acyl
groups comprising from 8 to 30 carbon atoms, R.sub.2 is chosen from a hydrogen atom, linear and
branched, saturated and unsaturated alkyl groups comprising from 1 to 30 carbon atoms, and linear
and branched, saturated and unsaturated acyl groups comprising from 1 to 30 carbon atoms, and n
is a number ranging from 80 to 350. Processes comprising such oil-in-water nanoemulsions.
Cosmetic or dermopharmaceutical composition in the form of beads and methods for preparing same
The invention concerns an anhydrous solid composition comprising at least a hydrophobic wax, an
oil and talcum, having preferably the form of beads with size ranging from 1 to 10000 microns. The
beads can contain a cosmetic or pharmaceutical active principle, pigments or an agri-food
constituent. The invention also concerns the method for preparing said beads.
High pressure neon arc lamp
A high pressure neon arc lamp and method of using the same for photodynamic therapies is
provided. The high pressure neon arc lamp includes a housing that encloses a quantity of neon gas
pressurized to about 500 Torr to about 22,000 Torr. At each end of the housing the lamp is
connected by electrodes and wires to a pulse generator. The pulse generator generates an initial
pulse voltage to breakdown the impedance of the neon gas. Then the pulse generator delivers a
current through the neon gas to create an electrical arc that emits light having wavelengths from
about 620 nanometers to about 645 nanometers. A method for activating a photosensitizer is
provided. Initially, a photosensitizer is administered to a patient and allowed time to be absorbed
into target cells. Then the high pressure neon arc lamp is used to illuminate the target cells with red
light having wavelengths from about 620 nanometers to about 645 nanometers. The red light
activates the photosensitizers to start a chain reaction that may involve oxygen free radicals to
destroy the target cells. In this manner, a high pressure neon arc lamp that is inexpensive and
efficiently generates red light useful in photodynamic therapy is provided.
Composition especially in the form of emulsion, gel or aqueous solution, including a crosslinked poly(2acrylamido-2-methylpropanesulphonic acid) polymer neutralized to at least 90%
The invention relates to a cosmetic, dermatological, hygienic or pharmaceutical composition which
is in the form of, or includes, an aqueous gel or an aqueous, hydroalcoholic or multiphase solution
additionally including at least one crosslinked poly(2-acrylamido-2-methylpropanesulphonic acid)
polymer neutralized to at least 90% and pigments or water-soluble dyes.
Dibenzoylmethane sunscreen compositions containing photostabilizing amounts of tri-substituted butane
compounds
Improvedly photostable UV-photoprotecting cosmetic/dermatological compositions for the skin
and/or the hair contain (a) a UV-photoprotective amount of at least one dibenzoylmethane
sunscreen, e.g., 4-(tert-butyl)-4'-methoxydibenzoylmethane or 4-isopropyldibenzoylmethane,
advantageously (a') a UV-photoprotective amount of at least one 1,3,5-triazine sunscreen, e.g., 2[(p-(tert-butylamido]-4,6-bis[(p-(2'ethylhexyl-1'-oxycarbonyl)anilino]-1 ,3,5-triazine or 2,4,6tris[p-(2'-ethylhexyl-1'-oxycarbonyl)anilino]-1,3,5-triazine, (b) an effective sunscreen
photostabilizing amount of 1,1,1-tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane, formulated
into (c) a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.
Synergistically UV-photoprotecting mixed sunscreen compositions
Topically applicable cosmetic/dermatological sunscreen composition well suited for the enhanced
UV-photoprotection of human skin and/or hair, contain synergistically UV-A.sub.PPD -enhancing
amounts of (i) at least one UV-screening silicon compound having a benzotriazole functional group
substituent, (ii) at least one UV-screening dibenzoylmethane compound, and (iii) at least one UVscreening amino-substituted 2-hydroxybenzophenone compound having the following structural
formula (III): ##STR1## formulated into (iv) a topically applicable, cosmetically/dermatologically
acceptable vehicle, diluent or carrier therefor.
Synergistically UV-photoprotecting compositions comprising mixed screening agents
Topically applicable cosmetic/dermatological sunscreen compositions well suited for the enhanced
UV-photoprotection of human skin and/or hair contain synergistically UV-A.sub.PPD -enhancing
amounts of (a) particulates of at least one insoluble organic UV-screening agent having a particle
size ranging from 10 nm to 5 .mu.m, and (b) at least one UV-screening amino-substituted 2hydroxybenzophenone compound having the following structural formula (I): ##STR1##
formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent
or carrier therefor.
Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
formula (I): ##STR1## in which Ar.sub.1 is a radical having one of the structural formulae (a)-(c):
##STR2## Ar.sub.2 is a radical having one of the following formulae (d)-(h): ##STR3## and X is a
radical having one of the following formulae (i)-(l): ##STR4## and are useful for the treatment of a
Chitosan compositions
Compositions comprising chitosan in the form of a network of nano-sized fibres. There is also
provided a process for making such compositions. The compositions have improved solubility and
activity. The compositions are useful in hair care, skin care, odour control, wound care, blood
management, sanitary compositions, oral care, film formation, hard surface treatment, fabric
treatment, release of hydrophobic or hydrophilic materials, plant care, water purification and drug
delivery.
Amino acid compounds and photoprotecting compositions comprised thereof
Amino acid compounds having the formula (I): ##STR1## are well suited for the UVphotoprotection of human skin and/or hair, as well as for the UV-photoprotection of a wide variety
of photosensitive industrial materials/substrates, e.g., plastics, glasses, textiles, etc.
Insect repellant compositions
The present invention relates to insect repellant compositions containing, based upon the total
weight of the composition, from about 6 to about 30 percent by weight of insect repellant active
material having functionality selected from ester, amide, urethane or combinations thereof; from
about 5 to about 30 percent by weight of alcohol, and from about 1 to about 10 percent by weight
of nonionic surfactant. The compositions of the invention exhibit reduced rates of degradation of
the active material in solution and are less drying and irritating to sensitive skin.
Use of amphoteric surfactants in cosmetic compositions to precipitate cationic polymers on dilution
Devices and methods for dispensing
A device for dispensing comprises a reservoir containing a composition comprising particles
containing at least one fluid, an application member having at least a portion removably disposed
within the reservoir and configured to be loaded with the composition and a compacting member
configured to exert pressure on at least the portion of the application member during removal of the
portion of the application member from the reservoir.
Topical application of chromophores for hair removal
A device and method is disclosed for permanent or semi-permanent removal of hair through the
activation of microparticles introduced into hair follicles. Microparticles are incorporated into a
composition that is topically applied to the skin. These microparticles containing or consisting of
chromophores or chemically activated molecules are of a variety of shapes and sizes.
Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50
microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin
without entering other areas of the skin, such as the stratum corneum or sweat gland channels.
Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means
activates the chromophore or chemically activated compounds, thus destroying the hair follicle
without damaging other areas of the skin. In another embodiment, microparticles further contain
nanoparticles released further into the hair follicle by use of a solvent or other method, allowing
chromophores or chemically activated molecules to penetrate deeper into the follicle and avoid
structures such as the sebaceous gland.
Nanoemulsion based on sugar fatty esters or on sugar fatty ethers and its uses in the cosmetics,
dermatological and/or ophthalmological fields
A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm,
comprising a surfactant which is solid at a temperature of less than or equal to 45.degree. C., which
surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a
sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the
amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be
used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or
mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye
lotion for treating the eyes.
UV-photostabilized sunscreen compositions comprising dibenzoylmethane/triazine/benzophenone
compounds
Topically applicable cosmetic/dermatological sunscreen compositions well suited for the stable
UV-photoprotection of human skin and/or hair, are devoid of any p-methylbenzylidenecamphor,
but which contain (a) an effective photoprotecting amount of at least one UV-sunscreening
dibenzoylmethane compound, (b) an effective photoprotecting amount of at least one UV-screening
1,3,5-triazine compound normally photosensitive in the presence of a dibenzoylmethane compound
(a), and (c) an effective photostabilizing amount of at least one UV-screening amino-substituted 2hydrozybenzophenone compound having the following structural formula (VIII): ##STR1##
formulated into (d) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent
UV-photostabilized sunscreen compositions comprising dibenzoylmethane/benzophenone compounds
UV-photoprotection of human skin and/or hair are devoid of any p-methylbenzylidenecamphor, but
contain (a) an effective photoprotecting amount of at least one UV-screening dibenzoylmethane
compound, and (b) an effective photostabilizing amount of at least on UV-screening aminosubstituted 2-hydroxybenzophenone compound having the following structural formula (I):
##STR1## formulated into (c) a topically applicable, cosmetically/dermatologically acceptable
vehicle, diluent or carrier therefor.
Synergistically UV-photoprotecting sunscreen compositions comprising camphorsulfonic
acid/benzophenone compounds
UV-photoprotection of human skin and/or hair, contain synergistically SPF-enhancing amounts of
(a) benzene-1,4-di(3-methylidene-10-camphorsulfonic acid), optionally in partially or completely
neutralized state, and (b) at least one amino-substituted 2-hydroxybenzophenone compound having
the following structural formula (I): ##STR1## formulated into (c) a topically applicable,
Anti-microbial body care product
An anti-microbial body care product comprising in the part contacting the human or animal skin
and/or mucosa and organic matrix containing homogeneously dispersed particles of a metallic
silver having a particle size in the range of 1 to 50 nm (silver nanoparticles) in an amount providing
on the surface of said part and anti-microbially effective but less than cytotoxic silver
concentration. Preferred body care products are disposable absorbent articles, toothbrushes,
cosmetic products and baby comforting products.
Method of amplifying a beneficial selective skin response to light energy
A method of altering the appearance of a region of skin is disclosed. The method includes applying
a sensitizing wavelength of light the region, and applying a treatment wavelength of light to the
skin, wherein the treatment wavelength is a shorter wavelength than the sensitizing wavelength.
The application of the sensitizing wavelength of light and the treatment wavelength of light results
in a change in a physical property of the skin.
Photoprotective cosmetic compositions containing aromatic amide, sulphonamide or carbamate
derivatives of acrylonitrile and novel aromatic amide, sulphonamide or carbamate derivatives of
acrylonitrile
Cosmetic compositions for topical use for protecting the skin and the hair, containing, in a
cosmetically acceptable support, at least one compound of formula (1) or (2) ##STR1## in which
X.sub.1 represents R.sub.3 --(C.dbd.O)--, R.sub.3 --SO.sub.2 -- or R.sub.3 --O--(C.dbd.O)--,
X.sub.2 represents --(C.dbd.O)--R'.sub.3 --(C.dbd.O)--, --SO.sub.2 --R'.sub.3 --SO.sub.2 -- or -(C.dbd.O)--O--R'.sub.3 --O--(C.dbd.O)--, Y represents --(C.dbd.O)--R.sub.4 or --SO.sub.2 R.sub.5,
R.sub.2 represents a C.sub.1-8 alkyl group, n is 0, 1 or 2, R.sub.3 represents C.sub.1-30 alkyl or
C.sub.3-30 alkenyl, R'.sub.3 represents a single bond or a divalent C.sub.1-30 alkylene or C.sub.330 alkenylene radical, R.sub.4 represents --OR.sub.6 or --NHR.sub.6, R.sub.5 represents C.sub.130 alkyl or a phenyl nucleus, R.sub.6 represents C.sub.1-30 alkyl or C.sub.3-30 alkenyl, and novel
compounds of formula (2).
Zinc oxide containing surfactant solution
A cleaning composition for all purpose cleaners, light duty liquids, shampoos such as hair cleaning,
foam baths, liquid hand soaps, and shower gels which comprises approximately by weight: (a) 1%
to 50%, more preferably 2% to 40% of at least one surfactant selected from the group consisting of
sulfonated anionic surfactants, sulfated anionic surfactants, zwitterionic surfactants, C.sub.12 C.sub.14 alkanol amide surfactants, amine oxide surfactants, ethoxylated nonionic surfactants,
ethoxylated/propoxylated nonionic surfactants and alkyl polyglucoside surfactants and mixtures
thereof; (b) 0.5% to 10%, more preferably 1% to 8% of at least one solubilizer; (c) 0.01% to 1%,
more preferably 0.03% to 0.5% of Nano-particulates of zinc oxide which function as an anti-irritant
system for the surfactants; and (d) the balance being water.
Photoprotective/cosmetic compositions comprising dibenzoylmethane/triazine/diphenylacrylate
compounds
suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UVA and UV-B irradiation, particularly solar radiation, comprise (i) 4-tert-butyl-4'methoxydibenzoylmethane, (ii) at least one particular 1,3,5-triazine compound, and (iii) at least one
alkyl .alpha.-cyano-.beta.,.beta.'-diphenylacrylate, formulated in a cosmetically/dermatologically
Silicon compounds derived from ascorbic acid
The invention concerns novel silicon compounds derived from ascorbic acid consisting of a siliconcontaining chain or of silanes, comprising at least a radical A of formula (I) wherein: at least one of
the radicals L is a divalent radical for fixing A on the silicon chain. The invention further concerns
methods for preparing said compounds, compositions, in particular cosmetic or pharmaceutical,
containing them, and their use as antioxidant and/or anti-free radical agent, particularly for treating
oxidant stress, for treating the effects of exposure to the sun and for preventing ageing. ##STR1##
USE OF AMPHIPHILIC COPOLYMERS TO STABILIZE DISPERSIONS OF INSOLUBLE
ORGANIC COMPOUNDS FOR SCREENING OUT UV RADIATION, DISPERSIONS STABILIZED
WITH THESE COPOLYMERS AND COSMETIC COMPOSITIONS CONTAINING THEM
The invention relates to the use of at least one amphiphilic copolymer comprising at least one
hydrophilic block and at least one hydrophobic block to stabilize dispersions of insoluble organic
compounds comprising at least one group that absorbs UV radiation, which is in the form of
particles with a mean size of between 10 nm and 5 .mu.m, and also to dispersions stabilized with
these amphiphilic copolymers and to cosmetic compositions for topical application, in particular
antisun compositions, containing them.
Nanoscopic hair care products
The present invention is directed to a hair treatment preparation comprising a payload in an
intimate relationship to a polymeric nanostructure, the polymeric nanostructure being reactive to
hair or capable of being immobilized onto or in hair. The nanoscopic nature of the entities being
engineered ensures three distinct characteristics. First, the imparted attribute can be either nearly
permanent or semi-permanent, depending on the attachment chemistry. In the semi-permanent
version, the intended effect can be controllably erased by removal of the nanostructure by simple
chemical or physical means. Second, the nanoscopic entities are invisibly small. Their presence
does not deteriorate the hand or feel of the hair. Third, the nano-technology approach is infinitely
flexible and adaptable. It can be coupled with many existing dyes, colorants, UV absorbers,
fragrances, softening agents and the like for hair treatment. Methods for treating hair with the hair
treatment preparations of the invention are also encompassed.
Use of particular aminosilicones as a pretreatment of processes for coloring keratin fibers with direct
dyes or with oxidation dyes
The present disclosure relates to the use, as a pretreatment of a process for coloring, with at least
one direct dye and/or with at least one oxidation dye, keratin fibers, such as human hair, of a
composition comprising at least one particular aminosilicone as defined herein. The disclosure also
relates to a process for coloring, with at least one direct dye and/or with at least one oxidation dye,
keratin fibers, such as human hair, comprising a pretreatment with a composition comprising at
least one particular aminosilicone as defined herein.
Use of particular aminosilicones as post-treatment of processes for coloring keratin fibers with direct
dyes or with oxidation dyes
A process for post-treating keratin fibres, after a process for coloring with at least one dye chosen
from direct dyes and oxidation dyes, by applying a composition comprising at least one
aminosilicone. Process for coloring, with direct dyes or with oxidation dyes, keratin fibres using the
composition.
Keratin fiber dyeing composition comprising a particular aminosilicone
The disclosure relates to a composition for dyeing human keratin fibres, such as hair, comprising in
a cosmetically acceptable medium at least one direct dye or at least one oxidation dye and at least
one aminosilicone. The disclosure further relates to dyeing devices and methods employing the
composition.
Sunscreen compositions comprising mineral oxides having hydrophobic coatings and glycosidesubstituted polydimethylsiloxanes
Stable, topically applicable cosmetic/dermatological compositions, notably W/O emulsions, well
suited for the UV-photoprotection of the skin, lips and/or the hair, and/or for the makeup of the skin
and/or the lips, contain a thus effective amount of at least one mineral oxide having a hydrophobic
coating thereon, e.g., coated particulates of an oxide of titanium and/or zinc, and, as a stabilizing
agent therefor, a thus effective amount of at least one oxyalkylenated polydimethylsiloxane bearing
at least one glycoside residue substituent, formulated into a physiologically acceptable medium
therefor.
Synergistically high SPF photoprotective UV-screening compositions comprising benzotriazolesubstituted silicon/dibenzoylmethane/diarylbutadiene compounds
Topically applicable, enhanced SPF cosmetic/dermatological UV-screening compositions suited for
the photoprotection of the skin and/or hair, comprise, (i) at least one UV-screening benzotriazolesubstituted silicon compound, as a first screening agent; (ii) at least one UV-screening
dibenzoylmethane compound, as a second screening agent; (iii) at least one 4,4-diarylbutadiene
compound, as a third screening agent, formulated into a topically applicable,
cosmetically/dermatologically acceptable vehicle therefor.
Composition containing a cationic polymer and water insoluble solid material
The compositions of the present invention relate to personal cleansing compositions having from
about 4% to about 50%, by weight, of a surfactant selected from the group consisting of an anionic,
cationic, nonionic, amphoteric, and zwitterionic surfactants and mixtures thereof; from about
0.05% to about 10% by weight of a dispersed, water insoluble solid particles or solid, temperature
stable particles; from about 0.025% to about 5% by weight of an organic, non crosslinked, cationic
homopolymer or copolymer having a cationic charge density of from about 2 meq/gm to about 10
meq/gm and an average molecular weight of from about 1,000 to about 5,000,000; from about
0.1% to about 10%, by weight, of a phase separation initiator selected from the group consisting of
electrolytes, amphiphiles and mixtures thereof; and from about 50% to about 95%, by weight, of
water.
Photoprotective cosmetic compositions comprising inorganic UV-blocking agents
Stable photoprotective cosmetic emulsions, notably water-in-oil emulsions well suited for the UVphotoprotection of the skin, lips, mucous membranes and/or hair, contain at least one aqueous
phase, at least one oily phase, an effective UV-photoprotecting amount of at least one coated or
uncoated metal oxide UV-blocking agent and an effective stabilizing amount of at least one
amphiphilic oligomer or polymer derived from a polyolefin which also comprises at least one polar
moiety, formulated into a physiologically acceptable medium therefor.
Use of nanoscalar water-soluble .beta.-(1,3) glucans
The invention relates to the use of nanoscalar water-soluble .beta.-(1,3) glucans, which are
essentially free from .beta.-(1,6) links and have particle diameters ranging from 10 to 300 nm for
producing cosmetic and/or pharmaceutical preparations. When applied topically, the especially fine
dispersion of the particles, compared to prior art glucans, facilitates their rapid penetration of both
the stratum corneum of the skin and the keratin fibres of the hair.
Plant extracts with anti-radical type action
epithet or appendage structures.
Cosmetic care or makeup composition for a keratin material comprising at least one photoprotective
agent and at least one ester comprising an aromatic group
A cosmetic care or makeup composition for keratin materials comprising, in a physiologically
acceptable medium, at least one photoprotective agent capable of screening out UV radiation and at
least one ester comprising an aromatic group, which is liquid at room temperature, resulting from
the esterification of an aromatic acid with at least one hydroxyl group chosen from pendent
hydroxyl group and terminal hydroxyl groups of hydroxylated aliphatic compounds said
hydroxylated aliphatic compounds being chosen from hydroxylated aliphatic acids and esters
thereof. Use of the said ester comprising an aromatic group to improve the photoprotective power
of compositions intended for protecting the skin and/or the lips and/or integuments against UV
radiation.
Cosmetic/dermatological compositions comprising a tetrahydrocurcuminoid and an amide oil
The invention relates to a cosmetic or dermatological composition containing a carrier comprising
at least one fatty phase characterized in that it contains at least one derivative or a mixture of
derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure and at least one oil
having, in its structure, at least one amide unit. The invention also relates to its uses in cosmetics
and dermatology, in particular for preventing or combating the harmful effects of UV radiation and
pollution on human keratinous materials, and more particularly for preventing and/or treating
photoaging of the skin. The invention also relates to a method for solubilizing a derivative or a
mixture of derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure with at least
one oil having, in its structure, at least one amide unit.
Aqueous antisun/sunscreen compositions comprising amphiphilic 2-acrylamidomethylpropanesulfonic
acid polymers and water-soluble silicones
Photoprotective compositions well suited for the photoprotection of the skin, lips and/or hair
against the damaging effect of UV-radiation comprise at least one aqueous phase and at least one
system for screening out UV-radiation, and which also contain: (a) at least one partially or totally
neutralized, crosslinked or non-crosslinked amphiphilic polymer of 2acrylamidomethylpropanesulfonic acid (AMPS), and (b) at least one water-soluble silicone
comprising at least one terminal or pendent monovalent polyoxyalkylene group.
Translucent nanoemulsion, production method, and uses thereof in the cosmetic, dermatological and/or
The nanoemulsion according to the invention comprises an oily phase dispersed in an aqueous
phase, having oil globules with a number-average size less than 100 nm, characterized in that it
contains a ternary surfactant system comprising: a) a mixture of at least two nonionic surfactants
comprising at least one ethoxylated fatty ester comprising 8 to 100 ethylene oxide units and at least
one fatty acid ester of sorbitan; and b) at least one ionic surfactant chosen from alkali metal salts of
cetyl phosphate and alkali metal salts of palmitoyl sarcosinate. Use in the manufacture of cosmetic,
dermatological and ophthalmological compositions.
Aqueous photoprotective compositions comprising acrylamido-2-methylpropanesulfonic acid polymers
and 4,4-diarylbutadiene UV-A sunscreens
Photoprotective compositions, e.g., oil-in-water or water-in-oil emulsions, well suited for the
photoprotection of the skin, lips and/or hair against the damaging effects of UV-radiation, comprise
at least one aqueous phase, at least one oily phase, at least one partially or completely neutralized,
crosslinked or non-crosslinked water-soluble or water-dispersible acrylamido-2methylpropanesulfonic acid (AMPS) polymer and at least one UV radiation-screening system, said
at least one screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent
Process to make dispersions
The present invention relates to the production of dispersions and is particularly suitable for making
dispersions with a viscous or solid dispersed phase in a continuous phase with a lower viscosity.
Use of particular aminosilicones as a pre- or post-treatment of processes for bleaching keratin fibers
A pre- or post-treatment composition for the process for bleaching human keratin fibers, such as
hair, comprising at least one particular aminosilicone as well as processes for bleaching human
keratin fibers, such as hair, comprising a pre- or post-treatment with a composition comprising at
least one particular aminosilicone.
Photoprotective compositions comprising sulfonic/hydrophobic amphiphilic polymers
Photoprotective cosmetic/dermatological compositions well suited for the UV-photoprotection of
human skin and/or hair, comprise (a) at least one organic UV-screening agent and (b) an SPFimproving amount of at least one amphiphilic polymerizate of at least one ethylenically unsaturated
monomer which comprises a sulfonic group, whether in the free acid or in partially or totally
neutralized state, and which amphiphilic polymerizate also comprises at least one hydrophobic
moiety.
Photostable UV-screening compositions comprising dibenzoylmethane/diarylbutadiene compounds
Topically applicable, photostable cosmetic/dermatological UV-screening compositions comprise
(a) at least one photolabile UV-screening dibenzoylmethane compound and (b) a dibenzoylmethane
photostabilizing amount of at least one 4,4-diarylbutadiene compound, formulated into a topically
applicable, cosmetically/dermatologically acceptable support therefor; the weight ratio of the 4,4diarylbutadiene compound(s) to the diarylbutadiene compound(s) is characteristically greater than
2.5 and the subject compositions are advantageously devoid of any cinnamate sunscreen.
Nanoemulsion containing nonionic polymers, and its uses
These objects and others may be accomplished with the present invention, the first embodiment of
which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an
aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic
amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one watersoluble nonionic polymer selected from the group including homopolymers and copolymers of
ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone;
homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl
methyl ether; neutral acrylic homopolymers and copolymers; C.sub.1 C.sub.2 alkyl celluloses and
their derivatives; C.sub.1 C.sub.3 alkyl guar; C.sub.1 C.sub.3 hydroxyalkyl guar; and combinations
thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i)
ranges from 1.2 to 10; and wherein the oily phase includes oil globules having a number-average
size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on
storage. It may form a composition for topical, preferably cosmetic or dermatological
compositions, pharmaceutical compositions and ophthalmological compositions.
Reducing composition for treating keratin fibres, comprising a particular aminosilicone
A cosmetic composition for treating human keratin fibers, such as hair, comprising, in a
cosmetically acceptable medium: (i) at least one reducing agent, and (ii) at least one particular
aminosilicone.The compositions can be used for bleaching and permanently reshaping human
keratin fibers. Processes and devices for bleaching or permanently reshaping human keratin fibers
using the composition.
Oxidizing composition for treating keratin fibers, comprising a particular aminosilicone
The disclosure relates to a cosmetic composition for treating keratin fibres, such as hair,
comprising, in a cosmetically acceptable medium: (i) at least one oxidizing agent; and (ii) at least
one aminosilicone.The disclosure further relates to the composition's uses, such as dyeing,
bleaching, and permanently reshaping keratin fibres.The disclosure also relates to the processes and
devices for bleaching, dyeing or permanently reshaping human keratin fibres using the
composition.
Photoprotective UV-screening compositions comprising (phenylsulfonyl) acrylonitrile-substituted
silanes/siloxanes
Novel (phenylsulfonyl)acrylonitrile siloxanes/silanes, and cosmetic/dermatological sunscreen
compositions comprised thereof, are well suited for UV-A photoprotecting the skin and/or the hair
against the damaging effects of solar radiation.
Use of particular aminosilicones as a pre-or post-treatment of processes for bleaching keratin fibres
The use, as a pre- or post-treatment of a process for bleaching keratin fibres, such as human hair, of
a composition comprising at least one particular aminosilicone as defined herein.Processes for
bleaching keratin fibres, such as hair, comprising a pre- or post-treatment with a composition
comprising at least one particular aminosilicone as defined herein.
Composition for dyeing human keratin materials, comprising at least one fluorescent dye and at least one
insoluble polyorganosiloxane conditioning polymer, process therefor and use thereof
Disclosed herein is a composition comprising at least one fluorescent dye and at least one insoluble
polyorganosiloxane conditioning polymer, processes using this composition, and a device.Further
disclosed herein is the use of compositions comprising at least one fluorescent dye and at least one
insoluble polyorganosiloxane conditioning polymer, for dyeing human keratin materials, for
example artificially dyed and/or pigmented hair and dark skin, with a tightening effect.
Formulation of UV absorbers by incorporation in solid lipid nanoparticles
Solid lipid nanoparticle compositions containing (a) 1 to 40% by weight of an oil-soluble UV
absorber, (b) 20 to 98.9% by weight of a solid lipid, (c) 0.1 to 20% by weight of an emulsifier and
(d) 0 to 40% by weight of a liquid lipid or a liquid oil-miscible UV absorberThe compositions
according to the invention enhance the solubility behaviour of oil-soluble UV filters in cosmetic
formulations and thereby also improve their effectiveness.
Composition for dyeing a human keratin material, comprising at least one fluorescent dye and at least
one insoluble conditioning agent, process thereof, use thereof, and devices thereof
A composition comprising at least one fluorescent dye and at least one insoluble conditioning
agent; and processes and multicompartment kits comprising the composition. This disclosure also
relates to the use of this composition for dyeing a human keratin material, and, for example,
artificially dyed or pigmented hair and/or dark skin, with a lightening effect.
Dibenzoylmethane sunscreen compositions photostabilized with amphiphilic block copolymers
Topically applicable photostable sunscreen/photoprotective compositions contain at least one
dibenzoylmethane UV-sunscreen and an effective photostabilizing amount therefor of at least one
amphiphilic block copolymer which comprises at least one nonionic hydrophilic polymer block and
at least one hydrophobic polymer block, formulated into a topically applicable, cosmetically
acceptable medium therefor.
Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic
sunscreen particles/diarylbutadiene compounds
Topically applicable high SPF cosmetic/dermatological UV-screening compositions suited for the
photoprotection of the skin and/or hair, comprise (a) particulates of at least one insoluble organic
UV-screening agent having a particle size ranging from 10 nm to 5 .mu.m, as a first screening
agent, and (b) at least one 4,4-diarylbutadiene compound, as a second screening agent, formulated
into a topically applicable, cosmetically/dermatologically acceptable vehicle therefor.
Photoprotective UV-screening compositions comprising triazine/dibenzoylmethane/diarylbutadiene
compounds
Topically applicable, photostable cosmetic/dermatological UV-screening compositions suited for
photoprotecting the skin and the hair, comprise (a) at least one UV-screening dibenzoylmethane
compound, (b) at least one UV-screening 1,3,5-triazine compound that is photosensitive in the
presence of a dibenzoylmethane compound, and (c) a 1,3,5-triazine photostabilizing amount of at
least one 4,4-diarylbutadiene compound, formulated into a topically applicable,
cosmetically/dermatologically acceptable support therefor; the weight ratio of the 4,4diarylbutadiene compound(s) to the dibenzoylmethane compound(s) is characteristically greater
than 2.5 and the subject compositions are advantageously devoid of any cinnamate sunscreen.
Sunscreen composition with enhanced SPF and water resistant properties
The present invention relates to a sunscreen formulation which exhibits superior ultraviolet
protection and water resistance than prior art sunscreen compositions. The sunscreen formulation
comprises (a) a dispersion comprising a sunscreen active agent and (b) a base composition
comprising a rheological modifying agent and water. The sunscreen formulation is substantially
free of surfactants. According to a preferred embodiment, the sunscreen active agent is
ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, or a combination thereof. The
sunscreen formulation preferably comprises a phosphorylated starch derivative as a rheological
modifying agent. Another embodiment of the present invention is a method of protecting skin or
hair from ultraviolet radiation by applying an effective amount of the sunscreen formulation of the
present invention to the skin or hair.
Cosmetic formulations comprising ZnO nanoparticles
The present invention relates to the formation of surface treated zinc oxide and titania particles, and
in particular zinc oxide and titania nanoparticles, with a siloxane star-graft copolymer coating,
comprising a looped and/or linear polymeric structure on a star-graft copolymer coating, on a
particle surface to control the interfacial surface interactions between the particle and the oil phase
of the cosmetic skin formulation.
Method and apparatus for improving safety during exposure to a monochromatic light source
A method and apparatus are disclosed for improving bodily safety during exposure to an eye
hazardous monochromatic treatment light source by diverging the light, such as with a diffusing
unit attached to the light source distal end so that the radiance of the light exiting the distal end is
an eye safe level. At a first position of the light source distal end substantially in contact with an
outer surface of a target, the energy density of an exit beam from the distal end is suitable for
effecting a desired treatment, and at a second non-contact position of the distal end the exit beam
energy density is significantly less than a value suitable for effecting the treatment. In an additional
embodiment, the diverging or diffusing unit has a device for evacuating vapors or particles from the
target.
Method for treating human keratin fibers with organomodified metallic particles
The present invention relates to the use of organomodified metallic nanoparticles preferably
bearing at their surface a self-assembled monolayer of organosulphur compounds. A preferred use
is in suspension form for dyeing and/or treating human keratin fibers. The invention also relates to
a process for dyeing and/or treating human keratin fibers, by the application to the keratin fibers of
such a suspension, and also to compositions used to perform such a process. The invention includes
the colouring and/or treating of human keratin fibers, in particular the hair, with the invention
suspension. Compositions of the nanoparticles with cosmetic active principles, and uses thereof,
also are described.
compound comprising an acid functional group and processes therefor
The present disclosure relates to compositions comprising at least one soluble fluorescent dye and
at least one compound comprising an acid functional group, and to processes using this
composition.It likewise relates to a method of using compositions comprising, in a cosmetically
acceptable medium, at least one soluble fluorescent dye and at least one compound comprising an
acid functional group for dyeing human keratin materials, such as artificially dyed and/or
pigmented hair and dark skin, with a lightening effect.
Composition for dyeing human keratin materials, comprising a fluorescent dye and a particular
sequestering agent, process therefor and use thereof
The invention relates to a composition comprising at least one fluorescent dye and at least one
particular sequestering agent, and also to processes and a device for using these compositions.The
invention similarly relates to the use of a composition comprising at least one particular fluorescent
dye and at least one particular sequestering agent, to dye with a lightening effect human keratin
materials and more particularly artificially dyed or pigmented hair, and colored skin.
Method of dyeing human keratin materials with a lightening effect with compositions comprising at least
one fluorescent dye and at least one amphoteric or nonionic surfactant, composition thereof, process
thereof, and device therefor
The present disclosure relates to a method of dyeing human keratin materials with a lightening
effect with a composition comprising, in a cosmetically acceptable medium, at least one fluorescent
dye that is soluble in the cosmetically acceptable medium and at least one surfactant chosen from
amphoteric surfactants and nonionic surfactants.The present disclosure also relates to compositions
comprising at least one particular fluorescent dye that is soluble in the cosmetically acceptable
medium and at least one surfactant chosen from amphoteric surfactants and nonionic surfactants,
and also to processes using these compositions, and devices for these compositions.
Apparatus and method for stimulating hair growth
A hand-held laser device that stimulates hair growth. The device provides distributed laser light to
the scalp while simultaneously parting the individual's hair to ensure that the laser light contacts the
individual's scalp. A unique beam splitting reflector splits a single laser beam to ensure that energy
from the laser beam is evenly distributed. The reflector is mechanically aligned with the laser
source and has a zigzag structure which mechanically deflects portions of the beam as it passes
over the peaks of the reflector. The portions of the laser beam form a line of laser beams that
project toward the individual's scalp. Parallel rows of teeth are aligned with a central row of
individual laser beams and part the individual's hair to form furrows in the individual's hair as the
device is combed through the individual's hair. The furrows create an unobstructed path for the
laser beam to reach the scalp of the individual. Another embodiment uses a non-coherent light
source to provide light energy to the individual's scalp. This embodiment also uses teeth to create a
series of furrows to provide unobstructed access to the individual's scalp by the light. In this
embodiment, the light source can be a series of LEDs or other lights aligned with the teeth, or a
single elongated light source which provides light across the area exposed by the teeth. Another
embodiment allows the use of a combination of laser light and non-coherent light.
polyol, process therefor and use thereof
Disclosed herein are compositions comprising at least one fluorescent dye and at least one polyol,
processes using this composition and a device therefor. Further disclosed herein is the use of a
composition for dyeing a human keratin material, such as artificially dyed or pigmented hair and
dark skin, with a lightening effect, comprising at least one fluorescent dye and at least one polyol.
associative polymer, process therefor and use thereof
Disclosed herein are compositions comprising at least one fluorescent dye and at least one
particular associative polymer, processes using this composition, and a device therefor. Further
disclosed herein is the use of a composition comprising at least one fluorescent dye and at least one
particular associative polymer for dyeing a human keratin material, such as artificially dyed or
Indanylidene compounds
Novel indanylidene compounds can be used as UV-A filters in cosmetic compositions for
protecting skin and hair and for technical applications.
Methods and compositions for improved fragrancing of a surface
The invention provides a method for improving release, on a surface, of a fragrance from an
entrapment structure of at least one fragrance oil and at least one entrapment material. The method
destabilizes the entrapment structure by providing at least one trigger molecule which preferentially
associates with the entrapment material; and/or at least one release agent which at least partially
disrupts the entrapment structure.The invention also provides a composition for improving release
of a fragrance from a surface. The composition comprises at least one fragrance oil; at least one
entrapment material, the at least one fragrance oil and the at least one entrapment material being
capable, in use, of forming an entrapment structure on the surface. The composition also comprises
at least one destabilizing material, which permits formation of the entrapment structure on the
surface but which destabilizing material can, in use, destabilize the entrapment structure by
providing at least one trigger molecule which preferentially associates with the entrapment
material; and/or at least one release agent which partially disrupts the entrapment structure; and at
least one compatible solvent which doesn't interfere with the formation of the entrapment structure
on the surface.The present methods and compositions can improve fragrance perception, by
overcoming the differences in fragrance perception that result from different surface, for example,
skin, hydration levels and/or different surface types.
Hair treatment method
A hair treatment device includes a generator of electromagnetic radiation and optical guide
components operatively connected to the generator so as to direct electromagnetic radiation from
the generator away from entering a skin surface and in a direction substantially parallel to the skin
surface, to impinge on hair fibers protruding from the skin surface. A control unit is connected to
the generator for controlling the generator to produce the electromagnetic radiation in bursts of
light pulses each having a predetermined number of pulses of light for treating the hair fibers
protruding from the skin surface.
Photoprotective cosmetic compositions comprising para-aminobenzalmalonate-substituted s-triazine
compounds
Cosmetic/dermatological sunscreen compositions, suited for photoprotecting, e.g., the skin, lips,
scalp and/or hair against the damaging effects of UV-radiation, contain thus effective amounts of at
least one novel s-triazine compound tri-substituted with para-aminobenzalmalonate substituents.
Cosmetic compositions containing a particular aminosilicone and a thickener, and uses thereof
A novel cosmetic composition comprising, in a cosmetically acceptable medium, at least one
aminosilicone of as defined herein having, for example, a contact angle ranging from 90.degree. to
180.degree. and at least one thickener, being able to afford at least one improved cosmetic property
(such as lightness, disentangling, volume and sheen) and/or at least one of long-lasting and
remanent effects, as well as uses of the composition, such as for washing and/or conditioning
keratin materials such as the hair or the skin.
Cosmetic compositions comprising at least one silicone copolymer and at least one additional silicone, and
uses thereof
Cosmetic compositions comprising, in a cosmetically acceptable medium, at least one silicone
copolymer with a dynamic viscosity ranging from 1.times.10.sup.6 to 100.times.10.sup.6 cP and at
least one additional silicone. This combination can give cosmetic properties, such as at least one of
smoothness, lightness, and softness, without the phenomenon of regressing keratin fibers. These
compositions can be used for washing and/or conditioning a keratin material, such as the hair or the
skin.
Cosmetic compositions containing a particular aminosilicone and a conditioner, and uses thereof
A novel cosmetic composition comprising, in a cosmetically acceptable medium, at least one
aminosilicone as defined herein having, for example, a contact angle with water ranging from
90.degree. to 180.degree. and at least one conditioner, being able to afford, for example, at least
one improved cosmetic property (such as lightness, disentangling, volume and sheen) and/or at
least one of long-lasting and remanent effects, as well as uses of the composition, such as for
washing and/or conditioning keratin materials such as the hair or the skin.
Diarylbutadiene-substituted methyltrialkylsilanes and photoprotective compositions comprised thereof
Novel 4,4-diarylbutadiene-substituted methyltrialkylsilanes having the structural formula (I):
##STR00001## are useful sunscreens for UV-photoprotecting human skin against the damaging
effects of UV-radiation, notably UV-A radiation.
Diarylbutadiene-substituted diorganopolysiloxanes and photoprotective compositions comprised thereof
Novel 4,4-diarylbutadiene-substituted diorganopolysiloxanes having the structural formulae (1) or
(2): ##STR00001## in which A is a radical of formula (3) below: ##STR00002## are useful
sunscreens for UV-photoprotecting human skin against the damaging effects of UV-radiation,
notably UV-A radiation.
Dye composition comprising at least one fluorescent dye and a non-associative thickening polymer for
human keratin materials, process therefor, and method thereof
The disclosure relates to a composition comprising at least one fluorescent dye and at least one
non-associative thickening polymer, to processes using such a composition, and to devices
comprising such a composition.The disclosure also relates to processes and methods for dyeing
human keratin materials, for example artificially dyed or pigmented hair and dark skin, with a
lightening effect, using compositions comprising at least one fluorescent dye and at least one nonassociative thickening polymer.
acrylonitrile
cosmetically acceptable support, at least one compound of formula (1) or (2) ##STR00001## in
which X.sub.1 represents R.sub.3--(C.dbd.O)--, R.sub.3--SO.sub.2-- or R.sub.3--O--(C.dbd.O)--,
X.sub.2 represents --(C.dbd.O)--R'.sub.3--(C.dbd.O), --SO.sub.2--R'.sub.3--SO.sub.2-- or -(C.dbd.O)--O--R'.sub.3--O--(C.dbd.O)--, Y represents --(C.dbd.O)--R.sub.4 or --SO.sub.2R.sub.5,
Hair restoration device and methods of using and manufacturing the same
The present invention provides for a hair restoration device and methods of manufacturing and
using the same. In one embodiment, the hair restoration device is comprised of (i) a hairbrush body
housing a plurality of wide-pattern laser LEDs configured to cooperate to project a precision laser
light pattern at a focal plane proximate a skin area to be irradiated; and (ii) bristles extending from
the hairbrush body and terminating substantially at the focal plane.
Hair coloring and cosmetic compositions comprising carbon nanotubes
The invention provides new hair colorant and cosmetic compositions comprising carbon nanotubes
that have either been chemically functionalized or physically modified to increase their affinity for
hair.
Polymeric particles and fragrance delivery systems
Polymeric micro- and nano-capsules formed of a spherical single hydrophobic polymer, chemically
functionalised at their surface so as to comprise hydrophilic moieties thereon are disclosed. The
capsules are susceptible of absorbing a perfume and of being optionally coated with an amphiphilic
copolymer. They allow the preparation of perfume delivery systems, which provide a slow release
of perfuming materials while improving the substantivity of the perfume on a substrate.
Peptide-based body surface coloring reagents
Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails,
teeth, gums, and oral cavity surfaces. Diblock and triblock peptide-based body surface coloring
reagents formed by coupling a body surface binding peptide to a pigment binding peptide, either
directly or through a spacer, are described. The peptide-based body surface coloring reagents may
be used in conjunction with pigments to color body surfaces.
Photoprotecting/cosmetic compositions comprising benzotriazole and bis-resorcinyltriazine
Topically applicable sunscreen/cosmetic compositions suited for the improved photoprotection of
human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation,
comprise an effective SPF-maintaining and water remanence-enhancing amount of intimate
admixture of (a) at least one benzotriazole first sunscreen compound and (b) at least one bisresorcinyltriazine second sunscreen compound, formulated into (c) a topically applicable,
Cosmetic and cosmeceutical compositions for restoration of skin barrier function
Compositions, kits and methods are provided for restoring skin barrier function to skin exposed to
environmental elements and/or in a pathological condition. In general, divalent cations such as
calcium ions and/or magnesium ions are included in a physiologically acceptable medium. In some
embodiments, divalent cations are balanced with monovalent cations such as sodium and potassium
ions at appropriate ratios in order to maintain the homeostasis of skin barrier. The compositions,
kits and methods can be used as cosmetics, cosmeceuticals or pharmaceuticals for improving skin
condition, and preventing or treating dermatological diseases and skin disorders.
Long lasting waterproof sunscreen comprising metal oxide and peptide conditioner
The disclosure provides a sunscreen formulation comprising a peptide-based metal oxide sunscreen
agent, such as titanium dioxide nanoparticles, and a fluid vehicle.
Vitamin D analogues
Novel biaromatic vitamin D analogues have the general formula (I): ##STR00001## and are suited
for a wide variety of pharmaceutical applications, whether in human or veterinary medicine, and
also for cosmetic applications.
Phase inverted oil-in-water photoprotective emulsions comprising nanopigments of metal oxides and 4,4diarylbutadiene UV-A sunscreens
Stable UV-photoprotective, phase inverted oil-in-water emulsions, well suited for the
photoprotection of the skin, lips and/or hair, the average size of the globules which constitute the
oily phase thereof ranging from 100 nm to 1,000 nm, contain inorganic metal oxide nanopigments
and at least one organic UV-screening agent, and which also contain at least one organic 4,4diarylbutadiene UV-A-screening agent.
Aqueous photoprotective compositions comprising diblock or triblock copolymers and 4,4diarylbutadiene UV-A sunscreens
at least one aqueous phase, at least one water-soluble or water-dispersible polymer having a diblock
structure A-B or a triblock structure B-A-B wherein A is an ionic water-soluble polymeric block
and B is a hydrophobic polymeric block and at least one system screening out UV radiation, said at
least one screening system comprising at least one 4,4-diarylbutadiene UV-A screening agent.
Antiaging cosmetic delivery systems
The present invention provides a comprehensive solution to the problems associated with natural
topical aging via the incorporation of: (i) An Extra-cellular antioxidant or Free-radical neutralizing
composition, and (ii) An Intra-cellular antioxidant or Free-radical neutralizing composition, and
(iii) An Anti-inflammatory composition, and (iv) A collagen or fibrin boosting composition. It is
preferred to also have the above incorporated in a suitable carrier base or topical delivery system
for skin, nail, and hair beneficial applications.
Laser therapy device for animals and methods of using the same and manufacturing the same
The present invention provides for a laser therapy device for animals and methods of
manufacturing and using the same. In one embodiment, the animal therapy device is comprised of
(i) a hairbrush body housing a plurality of wide-pattern laser LEDs configured to cooperate to
project a precision laser light pattern at a focal plane proximate an area to be irradiated; and (ii)
bristles extending from the hairbrush body and terminating substantially at the focal plane. Laser
light is used to treat different portions of the animal body.
Personal care compositions comprising semiconductor nanocrystals and methods of making and using
the same
A personal care composition that includes a personal care ingredient and semiconductor
nanocrystals. A method of protecting at least a portion of a body against ultraviolet radiation by
applying a personal care composition is also provided.
Photoprotective compositions comprising methyltrialkylsilanes containing a cinnamate, cinnamamide,
benzalmalonamide or benzalmalonate function
Unique photoprotective compositions contain novel methyltrialkylsilanes bearing a cinnamate,
cinnamamide, benzalmalonamide or benzalmalonate function, useful as sunscreens that are active
in the field of UV radiation.
Photostable photoprotective compositions comprising dibenzoylmethane and arylalkyl benzoate
compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s)
Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological
compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane
sunscreen and an effective photostabilizing amount of (ii) at least one arylalkyl benzoate compound
and (iii) at least one compound accepting the excited triplet level energy of said at least one
dibenzoylmethane sunscreen, formulated into (iv) a topically applicable,
cosmetically/dermatologically acceptable support therefor.
Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a
compound that accepts the excited triplet level energy of said dibenzoylmethane(s)
sunscreen and an effective photostabilizing amount of (ii) at least one oil containing at least one
amide structural unit and (iii) at least one compound accepting the excited triplet level energy of
said at least one dibenzoylmethane sunscreen, formulated into (iv) a topically applicable,
Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds/amidebased oils and photoprotective compositions comprised thereof
The present invention relates to a process for photostabilizing, with respect to UV radiation, at least
one dibenzoylmethane derivative with at least one arylalkyl benzoate derivative and at least one oil
containing in its structure at least one amide unit.Another subject of the invention also relates to a
novel cosmetic or dermatological composition for topical use, characterized in that it comprises, in
a cosmetically acceptable support: (a) at least one UV-screening agent of the dibenzoylmethane
derivative type and (b) at least one arylalkyl benzoate derivative and (c) at least one oil containing
in its structure at least one amide unit.The present invention also relates to the use of an arylalkyl
benzoate derivative and an oil containing in its structure at least one amide unit in a cosmetic or
dermatological composition comprising at least one dibenzoylmethane derivative, for the purpose
of improving the stability with respect to UV rays of the said dibenzoylmethane derivative.
Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds and
photoprotective cosmetic compositions comprised thereof
Topically applicable cosmetic/dermatological photoprotective compositions contain at least one
dibenzoylmethane UV-screening agent, and, as a photostabilizer therefor, at least one arylalkyl
benzoate compound of formula (I) or (II) below: ##STR00001## with the proviso that: (i) the
subject compositions are characteristically devoid of any octyl methoxycinnamate; and (ii) same
are other than a solution of butyl methoxydibenzoylmethane in 2-phenylethyl benzoate, 2phenylethyl o-toluate, 2-phenylethyl p-toluate or in a 2-phenylethyl o-toluate/2-phenylethyl ptoluate (1/1) mixture.
Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate/bis-resorcinyl
triazine compounds and photoprotective compositions comprised thereof
Topically applicable, photostable compositions with respect to UV radiation contain at least one
dibenzoylmethane UV-screening agent and at least one arylalkyl benzoate compound and at least
one bis-resorcinyl triazine compound.
Finely divided photoprotective oil-in-water emulsions comprising 4,4-diarylbutadiene UV-A sunscreens
UV-Photoprotective oil-in-water emulsions well suited for photoprotecting the skin, lips and/or hair
against the damaging effects of UV-radiation, the oil globules of which having an average size of at
most 500 nm and containing particles of at least one ionic polymer and at least one UV-radiationscreening system, such screening system comprising at least one 4,4-diarylbutadiene UV-Ascreening agent.
Sunscreen compositions comprising metal oxide mineral pigments and hydroxyalkylurea compounds
The invention relates to a composition comprising, in a cosmetically acceptable carrier, a system
for screening out UV radiation, characterized in that it contains:(a) at least metal oxide-based
mineral pigments, and(b) at least one hydroxyalkylurea of formula (I) below: ##STR00001## in
which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently represent a hydrogen atom, a
C.sub.1-C.sub.4 alkyl group or a C.sub.2-C.sub.6 hydroxy-alkyl group that may contain from 1 to 5
hydroxyl groups, at least one of the radicals R.sub.1-R.sub.4 representing a hydroxyalkyl group,
and also a salt, solvate or isomer thereof, said composition containing no kojic dipalmitate.The
invention also relates to the use of a hydroxyalkylurea of formula (I) in a composition comprising,
in a cosmetically acceptable carrier, at least metal oxide-based mineral pigments, for reducing, or
even eliminating, the whitening effect on the keratin material after application.
Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine
sunscreen and an effective photostabilizing amount of (ii) at least one bis-resorcinyl triazine
compound and (iii) at least one compound accepting the excited triplet level energy of said at least
one dibenzoylmethane sunscreen, notably at least one 4-hydroxybenzylidenemalonate compound,
4-hydroxycinnamate compound, fluorene compound, piperidinol salt, or mixture thereof,
formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support
therefor.
Peptide-based carbon nanotube hair colorants and their use in hair colorant and cosmetic compositions
Peptide-based carbon nanotube hair colorants are described. The hair colorants are prepared by
coupling hair-binding peptides to the surface of chemically functionalized carbon nanotubes. Hair
colorant and cosmetic compositions comprising the peptide-based carbon nanotube colorants are
also described.
Nanoparticulate compositions having lysozyme as a surface stabilizer
The present invention is directed to nanoparticulate active agent compositions comprising
lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical
compositions comprising a nanoparticulate active agent composition of the invention and methods
of making and using such nanoparticulate and pharmaceutical compositions.
RE37947
Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active aromatic polyenic compounds have the structural
human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and
US PATENT APPLICATIONS IN NANOTECHNOLOGY FOR HAIR CARE
PUBLISHED FROM 1980 TO 2008
Visit www.formulascan.com to read the complete document
Appl: 20010031247
Appl: 20020021932
Appl: 20020106390
Use of nanodispersions in cosmetic end formulations
A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming
molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which
nanodispersion is obtainable by (.alpha.) mixing the components (a), (b) and (c) until a
homogeneous clear liquid is obtained, and (.beta.) adding the liquid obtained in step (.alpha.) to the
water phase of the cosmetic end formulations, steps (.alpha.) and (.beta.) being carried out without
any additional supply of energy. The nanodispersions used according to this invention can be easily
prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oilsoluble dyes.
Appl: 20030024878
Process to make dispersions
The present invention relates to the production of dispersions and is particularly suitable for making
dispersions with a viscous or solid dispersed phase in a continuous phase with a lower viscosity.
Appl: 20030104020
delivery.
Appl: 20030138507
or dermopharmaceutical composition containing extracts of this type. The use of at least one plant
Appl: 20030195133
Targeted controlled delivery compositions activated by changes in pH or salt concentration
The present invention relates to a novel controlled release carrier system for pH or salt triggered
release and targeted delivery of fragrances and other active ingredients onto fabric, hair, skin, and
other biological surfaces and which provides prolonged release of fragrances and other active
ingredients over an extended period of time, or yields a high impact fragrance "burst" upon treating
the target surface with heat (blow drying the hair, ironing the fabric). The controlled delivery
system of the present invention is substantially a free-flowing powder formed of solid hydrophobic
nano-spheres comprising the fragrance and other active ingredients that are encapsulated in a pH or
salt sensitive micro-spheres. Also described are processes for preparing such compositions and
processes for using same. Furthermore, certain components of the aforementioned compositions in
combination with one another are novel, and other components have novel uses in increasing
fragrance substantivity, particularly in fabric, hair, and skin care preparations. The invention further
pertains to consumer and diversified products comprising the controlled release system of the
present invention.
Appl: 20030215479
Process for manufacture of hair or skin cosmetic products using apparatuses with microstructured units
A process for manufacturing hair cosmetic or skin cosmetic products is described, in which the
products contain a preparation with hair cosmetic or skin cosmetic ingredients and one process step
includes conducting at least a part of the preparation through an apparatus with microstructured
units. The apparatus with microstructured units can be one or more static micromixers and/or one
or more microheat exchangers.
Appl: 20030224060
Polyester polyol nanocapsules, compositions thereof, and methods of use
The present invention relates generally to nanocapsules having a core-envelope structure where the
core contains a lipophilic active agent and the envelope contains at least one polyester polyol
obtained by polycondensation of an aliphatic dicarboxylic acid with at least two alkanediols or with
at least one alkanediol and at least one hydroxyalkyl alkanediol. These nanocapsules make it
possible to stabilize lipophilic active agents that are difficult to stabilize, especially retinol esters
such as retinyl propionate.
Appl: 20030232091
Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
The present invention relates to a controlled release system useful to stabilize retinol, retinol
derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical
compositions. More specifically, the present invention pertains to stabilized retinol in a solid
hydrophobic particle that sustains the release of retinol during the product shelf life and enables a
gradual and prolonged release of effective levels of retinol and other cosmetic, dermatological, and
pharmaceutical active ingredients into biological surfaces. The present invention also refers to a
process of stabilizing retinol, retinol derivatives, and extracts containing retinol in cosmetic,
dermatological, and pharmaceutical compositions. The invention further relates to cosmetic,
dermatological, and pharmaceutical products comprising stable retinol in a hydrophobic particle
that can deliver effective levels of retinol and other cosmetic, dermatological, and pharmaceutical
active ingredients to biological surfaces over an extended period of time.
Appl: 20040014700
Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the
synthesis of melanic pigments, as depigmentation agents
The present invention relates to novel oligonucleotide sequences and also to derivatives thereof.
These novel oligonucleotide sequences are capable of hybridizing specifically with the gene or with
a product of the gene encoding tyrosinase, or with the gene or a product of the gene encoding
tyrosinase-related-protein 1 (TRP-1). The present invention also relates to the use of these novel
oligonucleotide sequences as a depigmenting or bleaching agent in a cosmetic composition or in a
dermatological composition.
Appl: 20040018165
Hair care compositions
A hair-care composition comprising an anti-dandruff effective amount of anti-microbial
oligoaminosaccharide comprising at least about 50%, preferably at least about 80% by weight of
oligoaminosacharides having from 1 to 50 monomer units. The invention also relates to the use of
the anti-microbial oligoaminosaccharide in a hair-care composition for providing anti-dandruff
activity.
Appl: 20040052760
Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the
growth and/or preventing or delaying the loss of hair
The invention relates to a cosmetic composition containing at least one 15-hydroxyprostaglandin
dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of
cosmetic treatment for promoting the growth and/or preventing or delaying the loss of hair, and the
use of a 15-hydroxyprostaglandin dehydrogenase inhibitor for the preparation of a composition
intended for controlling hair loss and/or for promoting hair regrowth.
Appl: 20040097398
Methods and compositions for improved fragrancing of a surface
The invention provides a method for improving release, on a surface, of a fragrance from an
entrapment structure of at least one fragrance oil and at least one entrapment material. The method
destabilises the entrapment structure by providing at least one trigger molecule which preferentially
associates with the entrapment material; and/or at least one release agent which at least partially
disrupts the entrapment structure. The invention also provides a composition for improving release
of a fragrance from a surface. The composition comprises at least one fragrance oil; at least one
entrapment material, the at least one fragrance oil and the at least one entrapment material being
capable, in use, of forming an entrapment structure on the surface. The composition also comprises
at least one destabilising material, which permits formation of the entrapment structure on the
surface but which destabilising material can, in use, destabilise the entrapment structure by
providing at least one trigger molecule which preferentially associates with the entrapment
material; and/or at least one release agent which partially disrupts the entrapment structure; and at
least one compatible solvent which doesn't interfere with the formation of the entrapment structure
on the surface. The present methods and compositions can improve fragrance perception, by
overcoming the differences in fragrance perception that result from different surface, for example,
skin, hydration levels and/or different surface types.
Appl: 20040107080
Method for modelling customised earpieces
The present invention relates to a method for computer-controlled modelling of customised
earpieces. These earpieces include housings for hearing aids, wireless or connected communication
devices (headsets, mobile phones, personal agents), loud speakers, tinnitus masking devices,
devices recording vibrations in the skull and transforming these into audio signals, voice
recognition devices, earplugs, noise blockers with selective frequencies or sound levels, Man
Machine Interface (MMI) products that enable clear communication even in the noisiest
environments, or products related to wireless Internet applications. All these earpieces may be worn
in the user's meatus and/or auditory canal. The invention also relates to a computerised system for
manufacturing such customised earpieces. In particular, the invention is directed to a computerised
system that models an earpiece based on a three-dimensional replica of the user's meatus and/or
auditory canal.
Appl: 20040115766
Method for producing proteins by fermentation of microorganisms from the thermus family the protein
mixture thus obtained and cosmetic compositions containing same
The use of fermentation media for microorganisms from the Thermus family, in particular
microorganisms collected in marine waters close to very deep hydrothermal sources, especially
those obtained with the GY1211 strain. Cosmetic compositions containing one or more types of
fermentation media for the microorganisms and which are used, in particular, for skin care, notably
for the face, body and scalp, and hair care and in order to modulate the cutaneous concentration of
ceramides, to stimulate the immune system, to provide protection by means of the chaperone effect
and a detoxifying and anti-free radical effect, particularly in relation to the oxygen peroxide.
Appl: 20040120918
Cosmetic or dermopharmaceutical compositions of ceramides and polypeptides
Personal care products including cosmetics, grooming products and topical pharmaceutical
products can be produced including a polypeptide of between 3 and 12 amino acids in length and a
ceramide. These formulations are particularly useful in addressing wrinkles in human subjects and
in particular facial skin and hands. Certain analogs and derivatives of these polypeptides may be
used in these formulations and/or alone. Methods of using these formulations are also disclosed.
Appl: 20040121019
Particles comprising a biopolymer which is degradable under the effect of an electromagnetic wave as
emitted by a solar radiation
The invention relates mainly to a particle comprising at least one biopolymer which is degradable
under the effect of an electromagnetic wavelength, notably the wavelength of which is in the
spectrum of the wavelengths emitted by the sun, this biopolymer comprising nucleosides. The
invention also relates to compositions containing such particles with the aim of delivering an active
principle. These particles can be used mainly in cosmetics, in dermatology, in pharmacy, in agrifood or en agro-industrials.
Appl: 20040151673
Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles
Nonaerosol/atomizer pumps or aerosol dispensers comprise (A) a reservoir confining at least one
vaporizable sunscreen composition suited for UV-photoprotecting the skin and/or hair against the
damaging effects of UV radiation, the at least one vaporizable sunscreen composition comprising
(1) a UV-photoprotecting amount of at least one UV-sunscreen and (2) an SPF-enhancing amount
of generally spherical silica microparticles, formulated into (3) a topically applicable, cosmetically
acceptable carrier therefor, and (B) at least one agent for pressurizing the at least one vaporizable
sunscreen composition into a spray of fine sunscreen particles.
Appl: 20040180147
Direct micro-patterning of lipid bilayers using UV light and selected uses thereof
This invention provides novel methods for creation of patterned lipid bilayer membranes as well as
methods for refunctionalization of such patterned membranes with selected components. Such
components optionally comprise, e.g., lipid bilayer membranes (which optionally comprise specific
proteins), proteins, non-biologic moieties, etc.
Appl: 20050142092
Cosmetic or dermopharmaceutical compositions which are used to reduce bags and circles under the eyes
The invention relates to novel cosmetic or dermopharmaceutical compositions for topical use which
are used to prevent the symptoms of cutaneous slackening and, more specifically, to treat the
visible signs of ageing and fatigue, such as bags and circles under the eyes. The inventive
compositions comprise, in a cosmetically-acceptable medium, a combination of at least two, and
preferably three, components selected from: a) hesperidin or the derivatives thereof; b) A.C.E.
enzyme inhibitor dipeptides; and c) oligopeptides R.sub.2-(AA).sub.n-Pro-Arg-OH, wherin
(AA).sub.n is a peptide chain, (AA) is any amino acid or any derivative of any amino acid, n is
included between 1 and 3, and R.sub.2.dbd.H or an alkyl chain having a carbon length of between
C.sub.2 and C.sub.22.
Appl: 20050153862
System and process for releasing encapsulated active ingredients
The present invention relates to a controlled release system that can be incorporated in cosmetic,
personal care, and household products to effectively encapsulate wide range of active ingredients
and sensory markers and release them in response to moisture or over an extended period of time.
The controlled release system of the present invention consists of oil absorbing polymer
nanospheres coated with water sensitive surface active polymers.
Appl: 20050175649
Enhancing properties by the use of nanoparticles
Composite materials comprising nanoparticles functionalized with metals are disclosed. The
composite materials may be used in a variety of applications, including in coating compositions,
cosmetic and pharmaceutical compositions, absorbent articles, and the like.
Appl: 20050186233
Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle
melanocytes
Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied,
to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the
follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to
maintain the natural pigmentation of gray or white head hair and/or body hair.
Appl: 20050208086
Administration of agents inducing DOPAchrome tautomerase (TRP-2) expression for protecting hair
follicle melanocytes
Agents inducing the expression of DOPAchrome tautomerase are administered, notably topically
applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal
of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities,
and to maintain the natural pigmentation of gray or white head hair and/or body hair.
Appl: 20050222071
Topical administration of at least one double-stranded RNA oligonucleotide (dsRNA)
Expression of a messenger RNA which encodes a protein which is expressed by differentiated
cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to
said differentiated cells a thus effective amount of at least one double-stranded RNA
oligonucleotide, formulated into a topically applicable, physiologically acceptable medium
therefor; such regime or regimen is useful for treating a variety of afflictions or conditions, e.g.,
combating the signs of skin aging, stimulating hair growth or retarding loss thereof, inhibiting
cellular proliferation and/or differentiation, etc.
Appl: 20050232955
Cosmetic compositions containing small magnetic particles
The present invention present a novel and cost-effective family of cosmetic compositions
comprising inter alia small magnetic particles characterized by magnetic field adapted to be
topically administrated adjacent to skin surface, absorbed to epidermal upper skin layers and place
in a direct contact to the body, usually above pain suffering regions. The present invention also
provides the use of the compositions, especially of nano-powders of salts obtained from the Dead
Sea, as an external layer of bandages, dressings, compresses or warps, so constantly approached to
be in an intimate contact with the patient's skin.
Appl: 20050238608
Polymeric particles and fragrance delivery systems
Polymeric micro- and nano-capsules formed of a spherical single hydrophobic polymer, chemically
functionalised at their surface so as to comprise hydrophilic moieties thereon are disclosed. The
capsules are susceptible of absorbing a perfume and of being optionally coated with an amphiphilic
copolymer. They allow the preparation of perfume delivery systems, which provide a slow release
of perfuming materials while improving the substantivity of the perfume on a substrate.
Appl: 20050255057
Appl: 20050283004
Alkylsulfonated polyaminosaccharides
Alkylsulfonated polyaminosaccharides, such as alkylsulfonated chitosan, having a sultone
substituent covalently bonded to the amino group and a known size and degree of substitution may
be produced by methods of the invention. Such methods may include heating of the
polyaminosaccharide in a polar solvent, such as alcohol, ether, or alcoholether to reflux, then
adding an alkyl sultone. Alkylsulfonated polyaminosaccharides of the present invention may be
used in a wide variety of applications. Alkylsulfonated chitosan is particularly useful in wound
healing.
Appl: 20060024257
Self-molding permanent agent and method for proceeding free-rod and free-band type permanent
The present invention relates to a self-molding permanent agent and a method for proceeding freerod and free-band type permanent, more particularly to a self-molding permanent agent comprising
(a) a reducing composition containing a reducing agent reducing a disulfide bond of cystine on the
hair and a molding stimulant spontaneously molding to fix a hair design; (b) a molding composition
inducing to mold after reacting with the molding stimulant; and (c) a softening composition
releasing the action of a molding stimulant, and a method for pressing a free-rod and free-band type
permanent, which overcomes a disadvantage in the conventional method for pressing a permanent
that needs to wear a curling device such as rods for a permanent (perm rod) or rubber band and
improves to apply a wave set without a hair-curling device for a short time, since it has a selfmolding feature.
Appl: 20060034786
Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin
appendages
Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole,
styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin
and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening
of the skin and/or skin appendages, notably for preventing and/or limiting canities.
Appl: 20060057094
Hair styling composition comprising at least one hydrophilic polymeric high porosity material and at
least one fixing polymer
Described herein is a hair styling composition comprising, in a physiologically acceptable liquid
medium: at least one hydrophilic polymeric high porosity material, and at least one fixing polymer,
with the proviso that the at least one hydrophilic polymeric high porosity material is not a silicone
polymer or an alkyl polymethacrylate polymer (PMMA). The compositions disclosed herein make
it possible to obtain a more strongly fixed and a longer lasting hair style.
Appl: 20060110343
Cosmetic or dermopharmaceutical compositions comprising tyramine derivatives, method for preparing
same, and use thereof
The invention concerns cosmetic or dermopharmaceutical compositions comprising tyramine
derivatives and their salts. The invention also concerns the method for preparing same and use
thereof for reducing pigmaentation.
Appl: 20060110413
Novel Molecules dervied from noraporphine
The invention concerns novel molecules derived from noraporphine, as well as cosmetic and
dermopharmaceutical compositions containing one or several of said derivatives, alone or
combined with a plant extract, in particular glaucium flavum, and particularly preparations for
reducing pigmentation, with anti-ageing effect or for slimming.
Appl: 20060134029
Personal care compositions comprising semiconductor nanocrystals and methods of making and using
the same
A personal care composition that includes a personal care ingredient and semiconductor
nanocrystals. A method of protecting at least a portion of a body against ultraviolet radiation by
applying a personal care composition is also provided.
Appl: 20060165643
Cosmetic or dermopharmaceutical compositions containing kombucha
Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The
present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical
compositions containing the same, alone or in combination, for the care of the skin, mucosae and
skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.
Appl: 20060182770
COSMETIC AND COSMECEUTICAL COMPOSITIONS FOR RESTORATION OF SKIN BARRIER
FUNCTION
Appl: 20060260627
Wig comprising cap with nano-silver
Disclosed herein is a wig comprising cap with nano-silver that exhibits antibacterial activity. The
wig comprising cap with nano-silver of the current invention exhibits antibacterial and disinfecting
effects on the hair and scalp of a wearer, by applying the net and lace each formed of fibers with
nano-silver to the cap of the wig, and/or by applying nano-silver to the hair of the wig. Thus, when
wearing the wig of the current invention, the scalp of the wearer may be kept healthy, and the
occurrence of skin diseases due to bacteria maybe prevented.
Appl: 20060263898
Perfume delivery systems based on inorganic nano particles
Nano-sized delivery systems consisting of an inorganic nano particle moiety covalently bonded to
at least one organic pro-perfume or pro-drug moiety are disclosed. The systems of the invention are
able to deliver perfuming or pharmaceutical active ingredients. Other aspects of the present
invention include the use of such systems in perfumery as well as the perfuming compositions or
perfumed articles that incorporate these delivery systems.
Appl: 20060264804
Device and kit for delivery of encapsulated substances and methods of use thereof
The present invention is of a kit and electricity generating device for delivery of an encapsulated
composition or mixture of compositions, including an electricity generating device and at least one
composition in an encapsulated carrier vehicle which is contacted or applied to the electricity
generating device. In some embodiments the device includes a means for maintaining stability of
the encapsulated composition prior to bio-membrane penetration. The present invention also
provides methods of use thereof. Furthermore, the present invention provides a device and method
for delivering a fixed ratio of compounds from a mixture to a bio-membrane comprising the step of
electro-transporting an encapsulated mixture of compounds. Still further, the present invention is of
a device and method for delivering each compound of a mixture of compounds to the same
penetration depth.
Appl: 20070043109
Slimming cosmetic composition
Cosmetic or dermopharmaceutical compositions containing, in a dermatologically acceptable
carrier, at least one diterpene among: cafestol, kahweol and chemical derivatives are useful for
slimming treatments including prevent and/or treat cellulite or orange peel and/or to refine contours
of the face, skin firming, to reduce the steatomery of the thighs, to decrease the volume/fatty
overload of the spare tire at the hips, to reduce "love handles", both on men and women.
Appl: 20070104670
Cosmetic composition comprising at least one specific fixative polymer and at least one sulphonated
polymer
The present invention relates to a cosmetic composition for treating keratin fibers, especially
human keratin fibers such as the hair, comprising in a cosmetically acceptable medium: at least one
fixative polymer comprising as monomers at least a vinyl lactam, an ethylenically unsaturated
carboxylic acid and an alkyl acrylate or methacrylate whose alkyl moiety contains at least 6 carbon
atoms, and at least one partially or fully neutralized sulphonated polymer containing at least one
unit derived from a sulpho-functional ethylenically unsaturated monomer.
Appl: 20070135335
Therapeutic molecules
The present invention relates generally to a ligand for a protein associated with modulating obesity,
diabetes and metabolic energy levels in animals including humans. More particularly, the present
invention provides a ligand of the protein, Beacon, and its homologs. The identification of a
Beacon ligand permits the identification of agents which agonize or antagonize the Beacon-ligand
interaction and, hence, the development of therapeutic molecules useful in modulating obesity,
diabetes and/or energy imbalance.
Appl: 20070140951
Nano-sized particles, processes of making, compositions and uses thereof
The present invention describes methods for preparing high quality nanoparticles, i.e., metal oxide
based nanoparticles of uniform size and monodispersity. The nanoparticles advantageously
comprise organic alkyl chain capping groups and are stable in air and in nonpolar solvents. The
methods of the invention provide a simple and reproducible procedure for forming transition metal
oxide nanocrystals, with yields over 80%. The highly crystalline and monodisperse nanocrystals are
obtained directly without further size selection; particle size can be easily and fractionally increased
by the methods. The resulting nanoparticles can exhibit magnetic and/or optical properties. These
properties result from the methods used to prepare them. Also advantageously, the nanoparticles of
this invention are well suited for use in a variety of industrial applications, including cosmetic and
pharmaceutical formulations and compositions.
Appl: 20070148634
CELLS HAVING A SPECTRAL SIGNATURE AND METHODS OF PREPARATIONS AND USE
THEREOF
Methods, compositions and articles of manufacture for encoding a cell with semiconductor
nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to
functional assays in mixed populations, and an assay result can be determined and associated with
individual cells by virtue of their code. The methods are particularly useful in multiplex settings
where a plurality of encoded cells are to be assayed.
Appl: 20070207101
Cosmetic Compositions Comprising Sub-micron Boron Nitride Particles
A cosmetic composition for use on hair, skin or nails, containing a safe and effective amount of
boron nitride powder has been found which improves the appearance of skin by blurring lines and
wrinkles while at the same time providing coverage of age spots, blemishes and other
discolorations.
Appl: 20070286856
Modulation of Hyaluronan Synthesis and Degradation in the Treatment of Disease
The present invention provides compositions and methods for modulating the expression of
Hyaluronan (HA). In particular, this invention relates to compounds, which hybridize with nucleic
acid molecules encoding hyaluronan synthase (HAS), particularly HAS isoforms HAS1, HAS2 and
HAS3. These compounds may range in size from oligonucleotides to full length sequences. Such
compounds are exemplified to modulate proliferation, such as cancer and inflammatory disorders,
such as arthritis. It will be understood, however, that the compounds can be used for any other
condition in which HA is involved.
Appl: 20080014229
Administration of compounds that increase glutathione levels in the melanocytes for the treatment of
canities
At least one compound that increases the level of glutathione (GSH) in the melanocytes of hair
follicles, and admixtures thereof with other active agents selected from among active agents for
combating desquamative conditions of the scalp, plant extracts having propigmenting activity and
active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or
limiting and/or stopping the development of canities.
Appl: 20080014380
IRIDESCENT FILM WITH BARRIER PROPERTIES
The present patent application is directed to an iridescent film having an outer coating. This product
has good barrier properties and thus, may be used in packaging of cosmetic and personal care
products in a flexible or rigid decorative container and in gas containing articles such as balloons
Appl: 20080026018
Administration of coumarin, butylated hydroxyanisole and ethoxyquine for the treatment of canities
At least one compound selected from among coumarin and/or derivative thereof, butylated
hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents
selected from among active agents for combating desquamative conditions of the scalp, plant
extracts having propigmenting activity and active agents that slow hair loss and/or promote hair
regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
Appl: 20080026019
Administration of ellagic acid for the treatment of canities
At least one compound selected from among ellagic acid, its salts, its metal complexes, its
monoether or polyether, monoacylated or polyacylated derivatives and its carbonate or carbamate
derivatives deriving from hydroxyl groups and mixtures thereof, and admixtures thereof with other
active agents selected from among active agents for combating desquamative conditions of the
scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or
promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development
of canities.
Appl: 20080027129
Administration of 3H-1, 2-dithiole-3-thione, anethole dithiolethione, sulforaphane, phenethyl
isothiocyanate, 6-(methylsulfinyl)hexyl isothiocyanate and allyl isothiocyanate for the treatment of
canities
At least one compound selected from among 3H-1,2-dithiole-3-thione, anethole dithiolethione,
sulforaphane, phenethyl isothiocyanate, 6-(methylsulfinyl)hexyl isothiocyanate and allyl
isothiocyanate and derivatives and mixtures thereof, and admixtures thereof with other active
agents selected from among active agents for combating desquamative conditions of the scalp,
plant extracts having propigmenting activity and active agents that slow hair loss and/or promote
hair regrowth, are useful for preventing and/or limiting and/or stopping the development of
canities.
Appl: 20080044444
Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent,
selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer
selected from the group consisting of at least one surface-active agent; at least one polymeric agent
and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a
hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures
thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that
is substantially resistant to aging and to phase separation and or can substantially stabilize other
active ingredients. The invention further relates to a foamable composition further containing a
liquefied hydrocarbon gas propellant.
Appl: 20080092915
Hair Styling Apparatus
A hair styling apparatus comprising a handle and a hair styling member with a transparent window.
The transparent window has substantially transparent electric heating substances which are
distributed along the hair styling member.
Appl: 20080115846
Aqueous fluid photoprotective compositions comprising ester-terminated poly(ester amide) polymers
Enhanced SPF and/or reduced fluffing fluid compositions for photoprotecting the skin and/or the
hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective
system capable of screening out UV radiation; and (b) at least one ester-terminated poly(ester
amide) (ETPEA) polymer, formulated into (c) a topically applicable, cosmetically acceptable
aqueous support therefor; the subject aqueous compositions are advantageously vaporizable,
especially in the form of sprays, confined within a pressurization device.
Appl: 20080135245
Composition and Method For Making a Proppant
The present invention relates to proppants which can be used to prop open subterranean formation
fractions. Proppant formulations are further disclosed which use one or more proppants of the
present invention. Methods to prop open subterranean formation fractions are further disclosed. In
addition, other uses for the proppants of the present invention are further disclosed, as well as
methods of making the proppants.
Appl: 20080138296
Foam prepared from nanoemulsions and uses
The present invention provides a foamable composition for administration to the skin, body
surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory
system, vagina or rectum. The foamable oil in water nano emulsion composition includes: (a) a
nano oil globule system, comprising substantially of sub-micron oil globules; (b) about 0.1% to
about 5% by weight of at least one stabilizing agent, selected from the group consisting of (i) a
non-ionic surfactant, (ii) an ionic surfactant, and (iii) a polymeric agent; and (c) a liquefied or
compressed gas propellant at a concentration of about 3% to about 25% by weight of the total
composition, water and optional ingredients are added to complete the total mass to 100%. Upon
release from an aerosol container, the foamable composition forms and expanded foam suitable for
topical administration. The present invention further provides methods of treating, alleviating or
preventing a disorder of the skin, body cavity or mucosal surface using such foamable
compositions; and to methods of producing such foams having an improved bubble size.
Appl: 20080138379
Methods, treatments, and compositions for modulating Hedgehog pathways
The present invention relates to prevention of congenital deformations The invention further relates
to cancer inhibition and prevention. The invention further relates to methods and compositions to
modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate
patterning events gene expression during prenatal development, post-natal development and during
development in the adult organism.
Appl: 20080146478
ENCAPSULATED ACTIVE MATERIAL CONTAINING NANOSCALED MATERIAL
The present invention is directed to novel capsules containing active material and nanoscaled
material and to methods for making capsules with enhanced performance and stability. The
capsules are well suited for use in personal care applications, laundry products and perfume and
fragrance products.
Appl: 20080166303
Colored or colorable foamable composition and foam
There is described a colored or colorable topical composition, comprising: a) a foamable base
composition comprising, 1) a flowable carrier composition; 2) a color agent; wherein the color
agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from
the foamable composition and wherein the color agent is one or more agents selected from the
group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a
dye, a colorant and a coloring agent; b) a propellant at a concentration of about 3% to about 25% by
weight of the total composition; wherein the base composition has a first color; and wherein the
foam comprising the colored or colorable topical composition has a second color upon dispensing
from an aerosol container, and wherein the first color and the second color are visually different.
There is also described a method of changing color, a method of administration, a use as a
diagnostic and a kit.
Appl: 20080183250
Compositions and methods for treating or preventing skin inflammation via restoration of skin barrier
function
Compositions, kits and methods are provided for restoring skin barrier function to skin of a subject
after a medical or a cosmetic procedure. In general, a composition containing divalent cations such
as calcium ions and/or magnesium ions in a physiologically acceptable medium can be used to
treat, inhibit or prevent inflammation of skin post medical, demertological, or cosmetic procedure
such as chemical peeling, laser skin resurfacing, microdermabrasion, plasma energy treatment,
radiofrequency treatment, hair or vein removal or lightening, skin treatment using light energy or
photofacial, thereby treating, inhibiting or preventing post-inflammatory hyperpigmentation of the
skin or other skin disorders.
Appl: 20080199503
Pharmaceutical Compositions Preparation of Peptides, Secreted by the Snake Venom Glands,
Particularly of Bothrops Jararaca, Vasopeptidases Inhibitors, Evasins, Their Analogues, Derivatives and
Products Associated, Thereof, for Development of Applications and Use in Chronic-Degenerative
Diseases
The present invention is characterized by the process of preparation of pharmaceutical
compositions for the development of applications of the Evasins and their structural and/or
conformational analogues in chronic-degenerative diseases. It is further characterized by the
process of preparation of pharmaceutical compositions and related products of the Evasins peptides
and their structural and/or conformational analogues in using the cyclodextrins, its derivatives,
liposomes and biodegradable polymers and/or mixture of these systems. The invention is further
characterized by the increased efficacy of these peptides and their analogues included in
cyclodextrins, when administered to rats. This characterizes an increased biodisponibility of these
peptides and their analogues using the compositions of the present invention.
Appl: 20080206320
COMPOSITION COMPRISING AT LEAST ONE 15-PGDH INHIBITOR
The invention relates to a cosmetic composition containing at least one 15-hydroxy-prostaglandin
dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of
cosmetic treatment for promoting the growth and/or preventing or delaying the loss of hair, and the
use of a 15-hydroxyprostaglandin dehydrogenase inhibitor for the preparation of a composition
intended for controlling hair loss and/or for promoting hair regrowth.
Appl: 20080206349
Spray Dried Compositions
The invention provides a method comprising the steps of: (i) providing an emulsion of: a) an
aqueous solvent, such as water, b) a carrier material dispersible or soluble in (a), said carrier
material being solid at ambient temperature, and preferably being a polymer and inorganic salt or a
surfactant, c) a volatile second liquid phase (for example, chloroform) which is not miscible with
(a), and d) a material which is dispersible or soluble in (c) but not in (a), and, (ii) Drying the
emulsion at above ambient temperature (preferably by spray drying) to simultaneously remove (a)
and (c) and thereby obtain the material (b) in solid form with (d) dispersed therein.
Appl: 20080213198
Cosmetic or Dermopharmaceutical Composition Comprising at Least one Udp Glucuronosyl Transferase
(Ugt) Enzymes Inducer
The invention relates to topical use of at least one UGT inducer for the preparation of a cosmetic or
dermopharmaceutical composition comprising a dermatologically acceptable carrier to protect
and/or enhance the state of the skin and prevent and/or treat imperfections of the skin.
Appl: 20080213572
HIGH PERFORMANCE GEOSYNTHETIC ARTICLE
Geotechnical article, and process for making it, the article having coefficient of thermal expansion
less than about 150 ppm/.degree. C. at ambient; resistance to acidic media greater than polyamide 6
resin and/or resistance to basic media greater than PET resin; resistance to hydrocarbons greater
than that of HDPE; creep modulus of at least 400 MPa at 25.degree. C., at 20% of yield stress load
for 60 minutes (ISO 899-1); and 1 percent secant flexural modulus at least 700 MPa at 25.degree.
C. (ASTM D790); the article including a composition including (a) from about 1 to about 95% by
weight of the composition of at least one functional group containing polymer or oligomer; and (b)
from about 5 to about 99% by weight of the composition of at least one engineering thermoplastic,
and optionally containing a filler and optionally containing an unmodified polyolefin, ethylene
copolymer or ethylene terpolymer.
Appl: 20080226684
METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND
RELEASING SYSTEMS
The present invention includes compositions, methods, systems and kits for the controlled delivery
of an active agent within a polymeric network upon the binding of a molecule that decreases the
structural integrity of the polymeric network at one or more micro- or nanovacuoles.
Appl: 20080317679
FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL
AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND
THEIR USES
The present invention relates to a foamable therapeutic composition comprising: (a) a
therapeutically effective concentration of at least one active agent selected from the group
consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable
carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of
water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an
emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group
consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent,
a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surfaceactive agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied
or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total
composition; wherein the composition is housed in a container and is substantially flowable, and
which upon release expands to form a breakable foam; and wherein the foamable carrier is selected
to generate a foam of good to excellent quality. The invention further provides a method of treating,
alleviating or preventing a disorder of mammalian subject, comprising administering such a
composition to an afflicted target site.
US PATENT APPLICATIONS IN NANOTECHNOLOGY FOR SKIN CARE
PUBLISHED FROM 2001 TO 2008
Visit www.formulascan.com to read the complete patent document
Appl: 20010027237
Comb copolymers for regulating cell-surface interactions
Synthetic comb copolymers which elicit controlled cellular response, methods of applying these
polymers to various surfaces, and methods of using the polymers for modifying biomaterial
surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb
copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding
side chains which can be end-capped with cell-signaling ligands that guide cellular response. By
mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial
distribution of one or more types of ligands, including adhesion peptides and growth factors, can be
tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as
stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be
applied to substrates by standard coating operations to create a bioregulating surface, or used as
drug delivery agents. In another embodiment, the combs can be blended in small quantities to a
hydrophobic matrix polymer and processed to affect the surface segregation of the comb. The comb
copolymers are formed in one embodiment by providing a biodegradable polyester backbone that
includes reactive groups, and reacting the reactive groups in the backbone with reactive chain ends
on a low molecular weight hydrophilic polymer. In another embodiment, non-biodegradable comb
copolymers are formed by free radical synthesis of a hydrophobic monomer and a hydrophilic
macromonomer. In all of the above embodiments, a portion of the hydrophilic polymer side chains
can be covalently coupled to cell-signaling ligands such as adhesion peptides or growth factors to
control cellular response.
Appl: 20010028893
Stabilized gas-supersaturated suspensions and methods for their delivery
The present invention provides a method of delivering an emulsion or suspension containing a
supersaturated gas into a gas-depleted environment. The method generally comprises the steps of
preparing an emulsion or suspension, exposing the emulsion or suspension to a gas at a pressure
greater than 2 bar, and delivering the emulsion or suspension to a gas-depleted environment at
ambient pressure.
Appl: 20010031247
Appl: 20010046574
Barrier laminate with a polymeric nanocomposite oxygen barrier layer for liquid packaging
The present invention relates to an improved laminate for containers of liquid, such as juice, the
laminate comprising: a paperboard substrate; an outer layer of a member selected from the group
consisting of heat-sealable low density polyethylene polymers and Plexar; and an inner barrier
layer of a polymeric nanocomposite blend comprising at least one resin and a layered silicate
dispersed in said resin. The layered silicate preferably has a layer thickness of about 7 to 12 A and
an interlayer thickness of about 30 A or greater.
Appl: 20020014182
Nanostructured fillers and carriers
A nanocomposite structure comprising a nanostructured filler or carrier intimately mixed with a
matrix, and methods of making such a structure. The nanostructured filler has a domain size
sufficiently small to alter an electrical, magnetic, optical, electrochemical, chemical, thermal,
biomedical, or tribological property of either filler or composite by at least 20%.
Appl: 20020019604
ELECTROCHEMICAL SENSOR WITH DUAL PURPOSE ELECTRODE
The present invention provides an electrode assembly for use in a transdermal analyte sensor
operating in an alternating polarity mode in which a single electrode element provides both the
counter electrode and iontophoretic electrode functions. By combining both the functions of the
iontophoretic and counter electrode, the surface area of the electrode with respect to each function
may be made larger. In turn this increases the ability of the electrode to deliver the required
electrical field over a larger area when operating in the iontophoretic mode as well as increasing the
ability of the counter electrode to compensate for the larger sensing electrode facilitated by this
new design.
Appl: 20020021932
Appl: 20020028991
Skin-mounted electrodes with nano spikes
Epidermally mountable device includes terminus structures to enable positive connection with
conductive tissue. The device includes nano spikes shaped to penetrate the epidermis of the skin to
collect electrical biopotentials such as cardiac depolarization waveforms (ECGs) and various
signals transmitted by implanted devices. Generally, the nano spikes are integrated on a substrate
comprising, preferably, a flexible metalized conductive plate attachable to an adhesive backing.
The device could be mounted on any external body of the patient to collect ECG, EEG or other
signals. Further, the device is adaptable to include a programmable microprocessor, including
memory and an antenna to store, receive and transmit data as needed. In one embodiment, in
addition to collecting physiologic data through direct contact, the device may also be used as a
smart patch to download, store and transfer data from implanted medical devices or other data
sources using wireless data transmission medium.
Appl: 20020037419
Thermal conductive sheet with conductive foil
A thermal conductive sheet with conductive foil is obtained by press bonding a magnetic foil to a
thermal conductive layer via a primer layer. Since the primer layer contains a thermal conductive
filler, it has high thermal conductivity and does not interrupt thermal conduction from the thermal
conductive layer to the magnetic foil. It also spontaneously destroys a skin layer on the surface of
the thermal conductive layer upon the press bonding. Accordingly, the thermal conductive sheet
with conductive foil of the present invention improves thermal conduction from the thermal
conductive layer to the conductive foil, eliminating the unfavorable effects of the skin layer and the
primer layer, and thus improves heat radiation of the thermal conductive sheet with conductive foil.
Appl: 20020051824
Treatment of hyperproliferative skin disorders and diseases
The invention relates to the use of one or more noble metals selected from silver, gold, platinum,
and palladium but most preferably silver, in a nanocrystalline form, for the treatment of a
hyperproliferative skin disorder or disease such as psoriasis. Among the noble metals, silver is
preferred for such treatment. The nanocrystalline noble metal of choice may be used in the form of
a nanocrystalline coating of one or more noble metals, a nanocrystalline powder of one or more
noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating
of one or more noble metals.
Appl: 20020082527
ASSESSMENT AND CONTROL OF ACOUSTIC TISSUE EFFECTS
A method for reversibly, or irreversibly, altering the permeability of cells, tissues or other
biological barriers, to molecules to be transported into or through these materials, through the
application of acoustic energy, is enhanced by applying the ultrasound in combination with means
for monitoring and/or implementing feedback controls. The acoustic energy is applied directly or
indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity
appropriate to alter the permeability to achieve the desired effect, such as the transport of
endogenous or exogenous molecules and/or fluid, for drug delivery, measurement of analyte,
removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as
kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the
strength of the acoustic field applied to the cell or tissue at the applied frequency or other
frequencies, and using the acoustic measurement to modify continued or subsequent application of
acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes
simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological
agent to be transported into or across the cell or tissue. In another preferred application, the method
includes removing biological fluid or molecules from the cells or tissue simultaneously, previously
or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid
or molecules.
Appl: 20020094515
Method and apparatus for attaching a microdevice or a nanodevice to a biological member
A method and apparatus for attaching a microdevice or nanodevice to a biological member is
disclosed. The biological member is one of a blood cell, lipid molecules, a liver cell, a nerve cell, a
skin cell, a bone cell, a lymph cell, an endocrine cell, a circulatory cell, a muscle cell. The
nanodevice or microdevice includes one of a diagnostic system, a transmitter, a receiver, a battery,
a transistor, a capacitor, and a detector.
Appl: 20020098472
Method for inserting a microdevice or a nanodevice into a body fluid stream
A method for inserting a microdevice or nanodevice into a body fluid stream is disclosed. The
micro or nanodevice may be inserted into or external to a cell, e.g., a red blood cell. For insertion
into the cell, techniques such as reversible osmotic lysis, electroporation, microfine needle
injection, and particle gun injection may be used. For the external device, it may be chemically
modified with an organo hydroxyl, such as poly (ethylene glycol), methoxypoly (ethylene glycol).
Also, it may include a lipid anchor.
Appl: 20020106390
Use of nanodispersions in cosmetic end formulations
A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming
molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which
nanodispersion is obtainable by (.alpha.) mixing the components (a), (b) and (c) until a
homogeneous clear liquid is obtained, and (.beta.) adding the liquid obtained in step (.alpha.) to the
water phase of the cosmetic end formulations, steps (.alpha.) and (.beta.) being carried out without
any additional supply of energy. The nanodispersions used according to this invention can be easily
prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oilsoluble dyes.
Appl: 20030014097
Heat-removal method and apparatus for treatment of movement disorder episodes
Heat-removal method and apparatus for treatment of movement disorder episodes; more
specifically, a device and method for intracranially suppressing movement disorder episodes upon
the detection of physiological symptoms. The device includes a temperature-contact implanted at a
targeted portion in the brain which is determined to be associated with such episodes and
connection to an implanted heat-transfer operator, typically a Peltier cooler or a thermal-electric
cooler. Heat transfer from the temperature-contact to the heat-transfer operator cools the targeted
portion and suppresses the movement disorder episode. Such heat transfer is performed upon the
sensing of symptoms which normally preface episodes. The symptoms can be sensed intracranially
by sensing-contacts, on the skin by a sensor or by a person or animal. Alternatively, heat removal
(cooling) can be performed without sensing symptoms to prevent episodes when the patient is
particularly sensitive to, or in danger from, episodes.
Appl: 20030021854
Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals
The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a
disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a
cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder,
and preferably in a nanocrystalline form. The nanocrystalline antimicrobial metal of choice may be
used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline
powder of one or more antimicrobial metals, or a solution containing dissolved species from a
nanocrystalline powder or coating of one or more antimicrobial metals.
Appl: 20030024884
Method for removing oil, petroleum products and/or chemical, pollutants from liquid and/or gas and/or
surface
The invention relates to the field of ecology, in particular to the struggle against pollution of the
environment with oil, petroleum products, cyclic and aromatic hydrocarbons, other chemical
pollutants, i.e. to purification of a water area, waste waters, industrial machinery, polluted soil and
grounds etc., and also to the field of objects used to satisfy the vital requirements of humans and to
medicine. A method for removing chemical pollutants includes preparing a carbonaceous mixture
of an expanded graphite and carbonaceous nanocrystals of a graphite-containing feedstock,
dispersing it onto the surface and/or into a liquid and/or placing on a surface and/or passing a liquid
or gas through a filter, and collecting the carbonaceous mixture saturated with the pollutants. The
method is used for collecting oil and petroleum products from the surface of water, for filtering
drinking water, is used for removing volatile fractions of petroleum products or gaseous condensate
from free basins of storage reservoirs, for neutralizing exhaust gases of internal combustion engines
as the base of a matrix of a neutralizer of exhaust gases, for filtering cigarette smoke, for purifying
blood plasma, for external use in the case of skin integument diseases characterized by discharges.
The invention makes it possible to enhance the effectiveness of the removal of oil and petroleum
products and also to ensure the removal of other chemical pollutants.
Appl: 20030054046
Treatment of inflammatory skin conditions
The invention relates to the use of one or more antimicrobial metals, most preferably silver,
preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment
of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in
the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder
of one or more antimicrobial metals, or a solution containing dissolved species from a
Appl: 20030072810
Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals
The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a
disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a
cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder,
and preferably in a nanocrystalline form. In another aspect of the invention, there is provided a
method of preventing excessive release of matrix metalloproteinases from an inflammatory cell in a
disease condition in a human or an animal by contacting the cell with a therapeutically effective
amount of a noble metal in a crystalline form characterized by atomic disorder, or with a solution
derived therefrom to provide a modulatory effect on one or more matrix metalloproteinases,
wherein the one or more noble metals is formed with atomic disorder, and preferably in a
nanocrystalline form. The nanocrystalline antimicrobial or noble metal of choice may be used in
the form of a nanocrystalline coating of one or more antimicrobial or noble metals, a
nanocrystalline powder of one or more antimicrobial or noble metals, or a solution containing
dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble
metals.
Appl: 20030078238
Stabilization method of nano-sized emulsion using tocopheryl derivatives and external application for
skin containing the same
Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl
derivatives represented by the following formula (I) and 1 (Wherein, R.sub.1, R.sub.2 and R.sub.3
are H or methyl group, and at least one position selected from the group consisting of the R.sub.1,
R.sub.2 and R.sub.3 positions are methyl group; and, A is CH.sub.2--CH(CH.sub.3)-- or
CH.dbd.C(CH.sub.3)--) and an external application for skin containing the stabilized nano-sized
emulsion.
Appl: 20030086977
Therapeutic treatments using the direct application of antimicrobial metal compositions
Therapeutic treatments using the direct application of selected structures of antimicrobial metals in
free-standing powder form, solution form and/or suspension form in therapeutically effective
amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an antiinflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor
agent, for human and/or animal use.
Appl: 20030104020
delivery.
Appl: 20030138507
or dermopharmaceutical composition containing extracts of this type. The use of at least one plant
Appl: 20030143412
Process for forming thermal conductive sheet
Appl: 20030148988
Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats
Telomere-encoding nucleic acid nanocircles, methods for their preparation, and methods for their
use are disclosed. The nanocircles can be constructed containing multiple repeats of the
complement of telomere repeat sequences. The telomere-encoding nanocircles are useful for
extending telomeres both in vitro and in vivo, for treating macular degeneration, the effects of skin
aging, liver degeneration, and cancer. The nanocircles are further useful for treating cell cultures to
produce long-lived non-cancerous cell populations. This use has wide applicability in scientific
research, tissue engineering, and transplantation.
Appl: 20030161795
Substantially visibly transparent topical physical sunscreen formulation
A topically applied sunscreen composition is provided, which by use of nano-sized particles of a
physical UV screening agent in a dermatologically acceptable carrier, provides a dermatologically
acceptable level of SPF and broad spectrum protection from UVA and UVB radiation, without the
need to include chemical UV screening agents in the composition.
Appl: 20030170187
Skin treatments containing nano-sized vitamin K
This invention relates to skin treatments containing nano-sized vitamin K. Specifically, the
invention relates to a skin treatment containing nano-sized vitamin K for the use in improving the
aesthetic aspects of the skin.
Appl: 20030170314
Compositions of metal-containing compounds
Compositions of metal-containing compounds are disclosed. Methods of preparing and using the
compositions, particularly in the treatment of a subject having a condition, are also disclosed. The
metal-containing material can be, for example, an antimicrobial material, an antibacterial material,
an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer
material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments,
the metal-containing material is an atomically disordered, silver-containing material.
Appl: 20030175315
Nanoemulsion comprising metabolites of ginseng saponin as an active component and a method for
preparing the same, and a skin-care composition for anti-aging containing the same
Disclosed herein is nanoemulsion prepared by emulsifying main metabolites of ginseng saponin
obtained by conversion of glucose, i.e. compound K (20-O-.beta.-D-glucopyranosyl-20(S)protopanaxadiol), ginsenoside F1 (20-O-.beta.-D-glucopyranosyl-20(S)-protopanaxatriol) and
compound Y (20-O-[.alpha.-L-arabinopyranosyl(1.fwdarw.6)-.beta.-D-glucopyranosyl]-20- (S)protopanaxadiol); and admixture thereof, in fine emulsion or liposome with dermotropic emulsifier
by nano-emulsification; and having enhanced skin penetration, so to be effective in promoting
proliferation of fibroblast and biosynthesis of collagen.
Appl: 20030175410
Method and apparatus for preparing biomimetic scaffold
Methods, compositions, and apparatus for preparing biomimetic scaffolds are provided. The
methods, compositions, and apparatus are compatible with both in situ and external scaffold
preparation. Also provided are methods for preparing scaffolds having 3-D spatial and/or temporal
gradients of therapeutic compounds, such as, growth factors, antibiotics, immunosuppressants,
analgesics, etc.
Appl: 20030180378
Dry powders of metal-containing compounds
Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry
powders, particularly in the treatment of a subject having a condition, are also disclosed. The metalcontaining material can be, for example, an antimicrobial material, an antibacterial material, an
anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a
pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metalcontaining material is an atomically disordered, silver-containing material.
Appl: 20030180379
Solutions and aerosols of metal-containing compounds
Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and
using the solutions and aerosols, particularly in the treatment of a subject having a condition, are
also disclosed. The metal-containing material can be, for example, an antimicrobial material, an
antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material,
an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain
embodiments, the metal-containing material is an atomically disordered, silver-containing material.
Appl: 20030183306
Selected processing for non-equilibrium light alloys and products
A new class of light or reactive elements and monophase .alpha.'-matrix magnesium- and
aluminum-based alloys with superior engineering properties, for the latter being based on a
homogeneous solute distribution or a corrosion-resistant and metallic shiny surface withstanding
aqueous and saline environments and resulting from the control during synthesis of atomic
structure over microstructure to net shape of the final product, said .alpha.'-matrix being retained
upon conversion into a cast or wrought form. The manufacture of the materials relies on the control
of deposition temperature and in-vacuum consolidation during vapor deposition, on maximized
heat transfer or casting pressure during all-liquid processing and on controlled friction and shock
power during solid state alloying using a mechanical milling technique. The alloy synthesis is
followed by extrusion, rolling, forging, drawing and superplastic forming for which the conditions
of mechanical working, thermal exposure and time to transfer corresponding metastable .alpha.'matrix phases and microstructure into product form depend on thermal stability and transformation
behavior at higher temperatures of said light alloy as well as on the defects inherent to a specific
alloy synthesis employed. Alloying additions to the resulting .alpha.'-monophase matrix include 0.1
to 40 wt. % metalloids or light rare earth or early transition or simple or heavy rare earth metals or
a combination thereof. The eventually more complex light alloys are designed to retain the low
density and to improve damage tolerance of corresponding base metals and may include an
artificial aging upon thermomechanical processing with or without solid solution heat and quench
and annealing treatment for a controlled volume fraction and size of solid state precipitates to
reinforce alloy film, layer or bulk and resulting surface qualities. Novel processes are employed to
spur production and productivity for the new materials.
Appl: 20030185889
Colloidal nanosilver solution and method for making the same
The present invention provides a colloidal nanosilver solution which contains nanosilver particles
having diameters between 1 nm and 100 nm. The silver content in the colloidal solution is between
0.001% to 0.4% by weight. The colloidal nanosilver solution also contains a gelling agent which
includes, but is not limited to, starch or its derivative, cellulose or its derivative, polymer or
copolymer of acrylate or acrylate derivative, polyvinyl pyrrolidone, alginic acid, and xanthogenated
gel. The present invention also provides a method for making the colloidal nanosilver solution. The
colloidal nanosilver solution prepared by this method does not contain any toxic or impure
substances.
Appl: 20030188740
Method for production of enhanced traceable immunizing drinking water and other liquid and gas
products, devices for production and use thereof, and use of the enhanced products for immunizing living
beings
A method for the production of enhanced traceable optp-physiological polished liquids, and gases
or solids or combination for immunizing living beings, devices using the method, use, and
preferred mode for utilization are disclosed. A multi processing platform is proposed according to
the invention harnessing time domain optronics of light & sound, wherein the transient sound
produced by light is measured, referenced or calibrated against the light produced by sound for the
formation adequate energy levels or densities or fluence rates for the purpose of dissociation of
noxious or innocuous species or combination constituents components while keeping their
geometrical integrity above their predetermined resonance levels, thus intact for later traceable
recognition and triggering of positive decisive action by immune systems.
Appl: 20030194444
Methods of treating skin and integument conditions
Methods of treating skin and integument conditions, particularly with metal-containing compounds,
are disclosed. The metal-containing material can be, for example, an antimicrobial material, an
Appl: 20030195133
Targeted controlled delivery compositions activated by changes in pH or salt concentration
The present invention relates to a novel controlled release carrier system for pH or salt triggered
release and targeted delivery of fragrances and other active ingredients onto fabric, hair, skin, and
other biological surfaces and which provides prolonged release of fragrances and other active
ingredients over an extended period of time, or yields a high impact fragrance "burst" upon treating
the target surface with heat (blow drying the hair, ironing the fabric). The controlled delivery
system of the present invention is substantially a free-flowing powder formed of solid hydrophobic
nano-spheres comprising the fragrance and other active ingredients that are encapsulated in a pH or
salt sensitive micro-spheres. Also described are processes for preparing such compositions and
processes for using same. Furthermore, certain components of the aforementioned compositions in
combination with one another are novel, and other components have novel uses in increasing
fragrance substantivity, particularly in fabric, hair, and skin care preparations. The invention further
pertains to consumer and diversified products comprising the controlled release system of the
present invention.
Appl: 20030198652
Multi component controlled release system for anhydrous cosmetic compositons
The present invention relates to an improved controlled release system that can be incorporated into
anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors, active
ingredients, or combinations of fragrances, flavors, and various active ingredients. The controlled
delivery system of the present invention is substantially free-flowing powder formed of solid
hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres. The
fragrances, flavors, and active ingredients encapsulated in the nano-spheres can be the same or
different from those encapsulated in the micro-sphere. The encapsulation of one or more
fragrances, flavors or active agents in the various components of the system, such as nano-spheres
and micro-spheres, provides odor or flavor transition (change in odor character or change in flavor
character) during the use of the product, in response to moisture, such as wetting the lips,
perspiration, and the like. The incorporation of the controlled release system of the present
invention into anhydrous cosmetic formulations was found to provide moisture triggered release, as
well as prolonged release of the fragrances, flavors, and active ingredients that are encapsulated in
the solid hydrophobic nano-spheres over an extended period of time.
Appl: 20030198680
Multi component moisture triggered controlled release system that imparts long lasting cooling sensation
on the target site and/or provides high impact fragrance or flavor burst
The present invention relates to cosmetic formulations comprising a multi component controlled
release system that imparts long lasting cooling sensation and/or provides high odor or flavor
intensity (i.e., high impact fragrance or flavor burst) in response to moisture. The controlled
hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres.
Appl: 20030203046
Appl: 20030207978
Non-spherical nanopowder derived nanocomposites
Nanocomposites from nanofillers with preferred form of whiskers, rods, plates and fibers are
disclosed. The matrix composition described includes polymers, ceramics and metals. The fillers
composition disclosed include inorganic, organic and metallic. These nanocomposites are useful in
wide range of applications given their unusual properties such as refractive index, transparency to
light, reflection characteristics, resistivity, permittivity, permeability, coercivity, B-H product,
magnetic hysteresis, breakdown voltage, skin depth, curie temperature, dissipation factor, work
function, band gap, electromagnetic shielding effectiveness, radiation hardness, chemical reactivity,
thermal conductivity, temperature coefficient of an electrical property, voltage coefficient of an
electrical property, thermal shock resistance, biocompatibility, and wear rate.
Appl: 20030212346
Methods of fabricating physiological sample collection devices
Methods of fabricating devices for collecting a sample of physiological and for measuring a
characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are
in the form of a test strip which include a biosensor and at least one skin-piercing element which is
a planar extension of a portion of the biosensor. The fabrication methods provide various or
forming the test strip and the skin-piercing element.
Appl: 20030215479
Process for manufacture of hair or skin cosmetic products using apparatuses with microstructured units
A process for manufacturing hair cosmetic or skin cosmetic products is described, in which the
products contain a preparation with hair cosmetic or skin cosmetic ingredients and one process step
includes conducting at least a part of the preparation through an apparatus with microstructured
units. The apparatus with microstructured units can be one or more static micromixers and/or one
or more microheat exchangers.
Appl: 20030219491
Compositions for inhibiting tumor growth and methods thereof
The present invention relates to a composition for inhibiting tumor growth, which comprises a
tumor growth inhibiting enzymatic moiety in association with at least one protective carrier. The
present invention further relates to the methods of inhibiting tumor growth using this composition.
Appl: 20030224060
Polyester polyol nanocapsules, compositions thereof, and methods of use
The present invention relates generally to nanocapsules having a core-envelope structure where the
core contains a lipophilic active agent and the envelope contains at least one polyester polyol
obtained by polycondensation of an aliphatic dicarboxylic acid with at least two alkanediols or with
at least one alkanediol and at least one hydroxyalkyl alkanediol. These nanocapsules make it
possible to stabilize lipophilic active agents that are difficult to stabilize, especially retinol esters
such as retinyl propionate.
Appl: 20030232091
Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
The present invention relates to a controlled release system useful to stabilize retinol, retinol
derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical
compositions. More specifically, the present invention pertains to stabilized retinol in a solid
hydrophobic particle that sustains the release of retinol during the product shelf life and enables a
gradual and prolonged release of effective levels of retinol and other cosmetic, dermatological, and
pharmaceutical active ingredients into biological surfaces. The present invention also refers to a
process of stabilizing retinol, retinol derivatives, and extracts containing retinol in cosmetic,
dermatological, and pharmaceutical compositions. The invention further relates to cosmetic,
dermatological, and pharmaceutical products comprising stable retinol in a hydrophobic particle
that can deliver effective levels of retinol and other cosmetic, dermatological, and pharmaceutical
active ingredients to biological surfaces over an extended period of time.
Appl: 20040014700
Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the
synthesis of melanic pigments, as depigmentation agents
The present invention relates to novel oligonucleotide sequences and also to derivatives thereof.
These novel oligonucleotide sequences are capable of hybridizing specifically with the gene or with
a product of the gene encoding tyrosinase, or with the gene or a product of the gene encoding
tyrosinase-related-protein 1 (TRP-1). The present invention also relates to the use of these novel
oligonucleotide sequences as a depigmenting or bleaching agent in a cosmetic composition or in a
dermatological composition.
Appl: 20040018259
Use of at least one extract of a plant of the genus lannea in a cosmetic or dermopharmaceutical
composition
A cosmetic composition containing: (a) at least one plant extract from a plant belonging to a genus
selected from the group consisting of Lannea, Odina, and mixtures thereof; and (b) at least one
active ingredient selected from the group consisting of an anti-radical agent, a tyrosinase-inhibiting
agent, a melanogenesis-inhibiting agent, an anticollagenase agent, an antielastase agent, a
cytoprotective agent, and mixtures thereof, for application onto a human substrate selected from the
group consisting of skin, mucous membranes and epithelial appendages.
Appl: 20040028875
Method of making a product with a micro or nano sized structure and product
Using phase separation technique perforated as well as non-perforated polymeric structures can be
made with high aspect ratios (>5). By varying the phase separation process the properties (e.g.
porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are
described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric
solar cells, ball grid arrays, and tissue engineering.
Appl: 20040057917
Pharmaceutical composition for treatment and /or prevention of a light-dermatosis
A pharmaceutical composition for treatment and prevention of light dermatosis includes (i) a
medical drug form nopal cactus, and (ii) at least one active substance with light-dermatosis
therapeutic properties and wherein the pharmaceutical composition is provided in a suitable form
for topical application.
Appl: 20040081780
Container closure with a multi-layer oxygen barrier liner
A container closure with a multiple layer liner. The liner comprises a nylon gas transmission barrier
and a non-nylon layer bonded by an adhesive layer. The nylon gas transmission barrier may contain
an additional passive gas transmission component comprising an in-situ polymerized inorganic
clay. An additional active gas transmission component comprising a chemically reactive scavenger
may be incorporated into at least one layer of the multiple layer liner. Materials of the liner are
selected for their process conditions and resulting resistance to degradation.
Appl: 20040110738
Prophylactic treatment methods
Prophylactic treatment methods are disclosed. The methods can include contacting an object and/or
an area of a subject with a metal-containing material to reduce the occurrence of a condition at the
same area or a different area of the subject. The metal-containing material can be, for example, an
antimicrobial material, an anti-biofilm metal-containing material, an antibacterial material, an antiinflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a proapoptosis material, an anti-proliferative material, an MMP modulating material, an atomically
disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the
metal-containing material is an atomically disordered, nanocrystalline silver-containing material.
Appl: 20040115692
Methods, compositions and apparatuses for detecting a target in a preservative solution
This invention relates to methods, articles and compositions useful in detecting target substances in
an alcoholic preservative solution, and for identifying sensors useful for binding to such targets.
The methods allow for the simultaneous performance of sufficient fixation of a sample and binding
of a detectable sensor to a target of interest in the sample. In one aspect, a method is provided that
comprises contacting a sample suspected of containing a target with a detectable sensor molecule
known to bind to such target in an alcoholic preservative solution. The method may be performed
in multiplex form to permit simultaneous analysis of a plurality of targets. Methods for identifying
a sensor capable of binding to a desired target in an alcoholic preservative solution are also
provided. An alcoholic preservative solution comprising one or more such detectable sensors is also
provided. Also provided is a sample comprising a bound sensor provided by such a process. Also
provided are kits useful for such methods.
Appl: 20040115766
Method for producing proteins by fermentation of microorganisms from the thermus family the protein
mixture thus obtained and cosmetic compositions containing same
The use of fermentation media for microorganisms from the Thermus family, in particular
microorganisms collected in marine waters close to very deep hydrothermal sources, especially
those obtained with the GY1211 strain. Cosmetic compositions containing one or more types of
fermentation media for the microorganisms and which are used, in particular, for skin care, notably
for the face, body and scalp, and hair care and in order to modulate the cutaneous concentration of
ceramides, to stimulate the immune system, to provide protection by means of the chaperone effect
and a detoxifying and anti-free radical effect, particularly in relation to the oxygen peroxide.
Appl: 20040120918
Cosmetic or dermopharmaceutical compositions of ceramides and polypeptides
Personal care products including cosmetics, grooming products and topical pharmaceutical
products can be produced including a polypeptide of between 3 and 12 amino acids in length and a
ceramide. These formulations are particularly useful in addressing wrinkles in human subjects and
in particular facial skin and hands. Certain analogs and derivatives of these polypeptides may be
used in these formulations and/or alone. Methods of using these formulations are also disclosed.
Appl: 20040121019
Particles comprising a biopolymer which is degradable under the effect of an electromagnetic wave as
emitted by a solar radiation
The invention relates mainly to a particle comprising at least one biopolymer which is degradable
under the effect of an electromagnetic wavelength, notably the wavelength of which is in the
spectrum of the wavelengths emitted by the sun, this biopolymer comprising nucleosides. The
invention also relates to compositions containing such particles with the aim of delivering an active
principle. These particles can be used mainly in cosmetics, in dermatology, in pharmacy, in agrifood or en agro-industrials.
Appl: 20040131698
Methods of treating conditions using metal-containing materials
Methods of treating conditions using metal-containing materials are disclosed. Exemplary
conditions include bacterial conditions, biofilm conditions, microbial conditions, inflammatory
conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions,
hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations of
such conditions. In certain embodiments, the metal-containing material is an atomically disordered,
nanocrystalline silver-containing material.
Appl: 20040131841
Conductive resin molded product having insulating skin and method for forming the same
To make the surface of a conductive resin molded product nonconductive with the resin by
adopting a carbon nano material as a conductive compounding material, and, accordingly, to make
it possible to expand the use of the conductive resin molded product and use it as a base material of
electronic equipment. The conductive resin molded product is produced out of composite material
of nonconductive resin and the carbon nano material. The conductive resin molded product is
comprised of an insulating skin 1 of the resin formed by blend control of the carbon nano material
and the conductive core 2 coated with the insulating skin 1.
Appl: 20040151673
Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles
Nonaerosol/atomizer pumps or aerosol dispensers comprise (A) a reservoir confining at least one
vaporizable sunscreen composition suited for UV-photoprotecting the skin and/or hair against the
damaging effects of UV radiation, the at least one vaporizable sunscreen composition comprising
(1) a UV-photoprotecting amount of at least one UV-sunscreen and (2) an SPF-enhancing amount
of generally spherical silica microparticles, formulated into (3) a topically applicable, cosmetically
acceptable carrier therefor, and (B) at least one agent for pressurizing the at least one vaporizable
sunscreen composition into a spray of fine sunscreen particles.
Appl: 20040161447
Liquid foam producing compositions and dispensing system therefor
By providing a therapeutic agent in a mixture of surfactants and water, a unique, improved, liquid
based foam producing formulation is realized which is useable for a wide variety of applications. In
the preferred embodiment, the improved liquid based foaming producing formulations incorporate
one or more therapeutic agents which comprise a silver-based composition. As a result, the
formulation is useable for a wide variety of medical applications for preventing, treating, or
reducing the spread or transmission of bacteria, virus, infections, and the like.
Appl: 20040180147
Direct micro-patterning of lipid bilayers using UV light and selected uses thereof
This invention provides novel methods for creation of patterned lipid bilayer membranes as well as
methods for refunctionalization of such patterned membranes with selected components. Such
components optionally comprise, e.g., lipid bilayer membranes (which optionally comprise specific
proteins), proteins, non-biologic moieties, etc.
Appl: 20040191329
Compositions and methods of metal-containing materials
Compositions and methods of metal-containing materials of metal-containing materials are
disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibiofilm material, an antibacterial material, an anti-inflammatory material, an anti-fungal material,
an anti-viral material, an anti-cancer material, a pro-apoptosis material, anti-proliferative, MMP
modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline
material. In certain embodiments, the metal-containing material is an atomically disordered,
nanocrystalline silver-containing material.
Appl: 20040197290
Cosmetic composition with skin tightening effect
The present invention relates to a mixture, having a skin-tightening effect, which is made up of: 10
to 80% by weight of a polysaccharide, preferably of an alginate, having a molecular weight of less
than 600,000 Daltons, preferably less than 400,000 Daltons and more preferably less than 200,000
Daltons, 15 to 75% by weight of a polyhydroxylated agent selected from sugars and their
derivatives, particularly sugar esters and sugar ethers, preferably sorbitol, 3 to 15% by weight of
poly(vinyl alcohol) or polyvinylpyrrolidone, and 0 to 25% by weight of cellulose or of a derivative
of cellulose, such as carboxymethylcellulose or hydroxymethylcellulose. The present invention also
relates to cosmetic compositions which contain this mixture. These cosmetic compositions enable a
mechanical smoothing of the surface of the skin to be obtained progressively with great comfort of
use and enables a good fixing of make-up products.
Appl: 20040219179
Skin abrasive agents
The present invention relates to compositions and methods for microderm abrasion. In particular,
the invention employs micro-sized particles that may be impacted into mammalian skin. The
particles may, themselves, include an active agent that is to be delivered through the stratum
corneum, or an active agent may be delivered through the abraded stratum corneum. The stratum
corneum may be abraded by active agents or topical compositions formed into particles, hyperbaric
particles, or other means.
Appl: 20040233465
Methods and ink compositions for invisibly printed security images having multiple authentication
features
An article is marked with image indicia for authentication, information, or decoration by providing
a plurality of inks having a plurality of fluorescence colors when exposed to excitation energy,
separating colors of the image indicia into a plurality of image levels in accordance with the
fluorescence colors of the inks, and printing each image level in mutual registration on the article
using the corresponding ink. The image printed with each ink may be substantially invisible under
illumination within the visible spectrum. The invisibly printed images have multiple authentication
features, including the use of covert UV-fluorescent materials, IR-fluorophores, microparticles, and
other chemical taggants. Ink compositions, methods for making the inks, and methods and
apparatus for using the inks are also disclosed.
Appl: 20040233526
Optical element with nanoparticles
Disclosed is an optical element comprising a substrate with surface features on a surface thereof
having an Ra of from 3 to 200 micrometers containing a dispersion of minute particles having a
particle size dimension less than 100 nanometers.
Appl: 20040254245
Cosmetic and dermopharmaceutical compositions for skin prone to acne
The invention relates to the use of an extract of olive leaves (Olea europaea) which is titrated in
oleanolic acid and which may or may not be associated with a Larrea divaricata extract which is
titrated in nordihydroguaiaretic acid (NDGA). Said products are intended for all types of cosmetic
and dermopharmaceutical compositions for all forms of skin care, for moisturizing and antiinflammatory purposes and, in particular, for the prevention and treatment of skin prone to acne.
Appl: 20050008495
Reduction in the noise produced by a rotor blade of a wind turbine
Rotor blades for wind power installations are known in many different forms. In a wind power
installation the rotors or the rotor blades thereof represent the main source of sound. For reasons
relating to acceptance and noise prevention laws, the aim should/must be that of minimizing the
levels of sound emission as wind power installations are often also set up in the proximity of
residential accommodation. The levels of sound emission which hitherto occur with a wind power
installation or a wind power converter also mean that wind power installations are faced with
resistance from populated areas because of the sound they produce and for that reason such
installations can be accepted sometimes with difficulty or not at all as authorities responsible for
planning permission refuse permission for wind power installations because of the existing
environmental requirements, noise also being an environmentally polluting factor. Therefore the
object of the invention is further to improve the noise emission of wind power installations. Wind
power installation rotor blade comprising means for reducing the sound produced by a rotor blade,
wherein the means is formed by a fluid-repellent layer and/or surface which is provided at least on
a surface portion of the rotor blade.
Appl: 20050013982
Hybrid natural-fiber composites with cellular skeletal structures
The present invention relates to composite structural members comprising polymers, natural and
synthetic fibers, and nano-scale platelets arranged in two- or three-dimensional cellular skeletal
structure; more particularly referring to a low-cost natural-fiber based structural member with
material hybridization and material layout for improved behavior that leads to efficient structural
beam and plate/panel components that can be used in a plurality of modular structures, resulting in
lower cost and reduced environmental impact.
Appl: 20050020923
Materials and methods for near-infrared and infrared lymph node mapping
A lymphatic system can be imaged with emissive semiconductor nanocrystals, for example, in the
near infrared.
Appl: 20050037165
Multilayer containers and process for forming multilayer containers
A co-injection process is provided for fabricating improved multi-layer containers, including but
not limited to blood collection tubes, evacuated blood collection tubes, culture bottles, centrifuges
tubes, and syringe barrels. The container includes a tube (10) having a bottom wall (12) and a side
wall (14) with an open end (18). The container can be provided with a stopper having an upper
portion (22) and a skirt with an outside portion (30), a well (34) and a cavity (36). The tube and
stopper assembly can be used for medical purposes including containing a blood sample within an
enclosed interior space (40).
Appl: 20050058652
Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive
toxic precipitates in the cancer
The invention features compositions and methods for treating or alleviating a symptom of cancer.
The compositions and methods of the invention direct supra-lethal doses of radiation, called HotSpots, to virtually all cancer cell types.
Appl: 20050065090
Dermopharmaceutically and cosmetically active oligopeptides
Oligopeptides and derivatives thereof, peptide analogs and derivatives thereof as well as
pharmaceutically acceptable salts of these compounds, which correspond to general formula (I) 1
wherein R.sup.1 represents H, --C(O)--R.sup.7, --SO.sub.2--R.sup.7, --C(O)--OR.sup.7 or --C(O)-N(R.sup.7).sub.2 R.sup.2 represents, independent of one another, H or --(C.sub.1-C.sub.4)-alkyl,
R.sup.3 and R.sup.6 represent, independent of one another, --(CH.sub.2).sub.q--N(R.sup.1)R.sup.8
R.sup.4 and R.sup.5 represent, independent of one another, --CH.sub.2--OR.sup.2, -CH(CH.sub.3)OR.sup.8 or --CH.sub.2--CH.sub.2--OR.- sup.8 R.sup.7 represents hydrogen,
optionally substituted (C.sub.1-C.sub.19)-alkyl; optionally substituted (C.sub.1-C.sub.19)-alkenyl;
phenyl-(C.sub.1-C.sub.4)-alkyl whose phenyl radical is optionally substituted with amino in the
para position R.sup.8 represents H, --(C.sub.1-C.sub.4)-alkyl, --C(O)--R.sup.7, --C(O)--OR.sup.7, -C(O)--N(R.sup.7).sub.2 or --SO.sub.2--R.sup.7 X represents oxygen (--O--) or --NH--; or
XR.sup.7, with X=O, also represents the esters of .alpha.-tocopherol, tocotrienol or retinol or the
carboxylic acid (with R.sup.7=H) m, n, p represent, independent of one another, zero or 1 and q in
R.sup.3 and R.sup.6 represent, independent of one another, an integer from 1 to 4, with the
provision that the following conditions do not simultaneously occur: R.sup.4=--CH(CH.sub.3)--OH
and R.sup.5=--CH(CH.sub.3)--OH and R.sup.6=--(CH.sub.2).sub.4--NH.sub.2;
dermopharmaceutically and/or cosmetically active compositions containing at least one compound
of formula (I).
Appl: 20050069900
Analyte sample detection
A method for assaying a sample for the presence of a target is provided. The method comprises
drawing a liquid sample transversely through a filter using an automated device that can control the
rate of flow through the filter. A sensor molecule is attached to the filter which can bind to a target
molecule. Binding of the target to the attached sensor molecule can then be detected through any of
various techniques. The methods may be performed in multiplex form to permit simultaneous
analysis of a plurality of targets. Kits for performing the methods are also provided.
Appl: 20050079983
Zinc oxide containing surfactant solution
A cleaning composition for all purpose cleaners, light duty liquids, shampoos, foam baths, liquid
hand soaps, fine fabric detergents, liquid skin cleansing products, dishware paste, dishware bars
and shower gels which include at least one surfactant, zinc oxide having a particle size of 10 to 30
nm, and water.
Appl: 20050080405
Thermal surgical procedures and compositions
Methods, compositions, and systems useful to enhance a thermal surgical procedure are described.
Compositions include at least one compound effective to induce an inflammatory response in
biological material identified to undergo a thermal surgical procedure. Methods and systems
include providing compositions of the invention to biological materials and treating biological
materials with an inflammation inducing composition for a time, amount, and type effective to
induce inflammation in at least a portion of the biological material.
Appl: 20050084901
Detection and quantification of prion isoforms in neurodegenerative diseases using mass spectrometry
Disclosed are methods, compositions and kits for diagnosing prion-mediated pathological
conditions and presence of aberrant prion protein in animal derived products, utilizing mass
spectrometry.
Appl: 20050089187
Nanoporous diaphragm for electromagentic transducer
An electromagnetic transducer such as a tweeter audio speaker, having a very low density
diaphragm constructed of a nanoporous material such as aerogel or the like. The solid aerogel
diaphragm has improved rigidity and reduced susceptibility to breakup modes. The aerogel may be
provided with a skin of e.g. metal, plastic, or oxide to protect it, and it may be built by filling a
conventional cone. The skin may encapsulate part or all of the aerogel body's surface, and it may
further encapsulate the bobbin, or even the entire voice coil assembly. The nanoporous material
comprises a very large percentage of the diaphragm's overall volume, giving the diaphragm a very
low overall mass density with respect to conventional diaphragms. This allows diaphragm
configurations, such as solid filled spheres, which have excellent stiffness without suffering from
the large mass that such shapes would mandate if constructed from conventional materials.
Appl: 20050095351
Method, apparatus and system for nanovibration coating and biofilm prevention associated with medical
devices
An acoustic indwelling medical device system, which may include a vibration apparatus and at
least one transducer, may be integrated with standard medical devices. This acoustic system may
use electric signals to enable the transducer to generate nanovibrations within the indwelling
medical device system, to inhibit the entry of microorganisms from external sources. Such
vibrations may enable dispersal of microbe colonies, thereby preventing or dispersing biofilm that
may cause infections.
Appl: 20050100937
Medical device for analyte monitoring and drug delivery
The invention relates to an ingestible, implantable or wearable medical device comprising a
microarray which comprises a bioactive agent capable of interacting with a disease marker
biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of
releasing the therapeutic agent(s) from the medical device; and a plurality of microchips
comprising a microarray scanning device capable of obtaining physical parameter data of an
interaction between the disease marker biological analyte with the bioactive agent; a biometric
recognition device capable of comparing the physical parameter data with an analyte interaction
profile; optionally a therapeutic agent releasing device capable of controlling release of the
therapeutic agent from the reservoirs; an interface device capable of facilitating communications
between the microarray scanning device, biometric recognition device and the therapeutic agent
releasing device; and an energy source to power the medical device. Specifically, the invention
relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one
microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the
sample flows and is in fluid communication with the at least one microneedle, a second
microchannel in fluid communication with the first microchannel, through which a buffer flows,
wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning
device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and
an interface device.
Appl: 20050112349
Polymeric nanofibers for tissue engineering and drug delivery
Polymeric nanofibers have been developed which are useful in a variety of medical and other
applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound
dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These
can be formed of any of a variety of different polymers, either non-degradable or degradable. In a
preferred embodiment demonstrated in the following examples, nanofibers are formed of
biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes
or with organic, inorganic/organometallic polymers as well as composite nanofibers of
polyphosphazenes with nanosized particles such as hydroxyapatites.
Appl: 20050115469
NANO DIATOMITE AND ZEOLITE CERAMIC CRYSTAL POWDER
A nano diatomite and zeolite ceramic crystal powder which is a new environmental material made
by combining high-quality natural diatomite and zeolite together and by using most advanced nano
technology, wherein the ceramic crystal powder has the capability of producing great benefits for
society through advances in health care, a cleaner environment, and agriculture.
Appl: 20050119202
Medicament to treat a fibrotic disease
The invention concerns a medicament to treat a fibrotic disease, wherein the medicament contains a
double-stranded ribonucleic acid (dsRNA) that is suitable for inhibiting by RNA interference the
expression of a gene that is involved in the formation of extracellular matrix.
Appl: 20050136042
Methods and compositions for tissue repair
Methods and compositions for tissue repair are provided. The methods involve obtaining tissue
from a patient, including for example, muscle or fat tissue, and contacting the tissue with one or
more bioactive agents to induce at least a portion of the cells in the tissue to differentiate into cells
of a desired type. The methods and compositions may be used to treat lesions in a variety of tissues,
including bone fractures or other injuries.
Appl: 20050136128
Dry powders of metal-containing compounds
Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry
powders, particularly in the treatment of a subject having a condition, are also disclosed. The metalcontaining material can be, for example, an antimicrobial material, an antibacterial material, an
anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a
pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metalcontaining material is an atomically disordered, silver-containing material.
Appl: 20050142092
Cosmetic or dermopharmaceutical compositions which are used to reduce bags and circles under the eyes
The invention relates to novel cosmetic or dermopharmaceutical compositions for topical use which
are used to prevent the symptoms of cutaneous slackening and, more specifically, to treat the
visible signs of ageing and fatigue, such as bags and circles under the eyes. The inventive
compositions comprise, in a cosmetically-acceptable medium, a combination of at least two, and
preferably three, components selected from: a) hesperidin or the derivatives thereof; b) A.C.E.
enzyme inhibitor dipeptides; and c) oligopeptides R.sub.2-(AA).sub.n-Pro-Arg-OH, wherin
(AA).sub.n is a peptide chain, (AA) is any amino acid or any derivative of any amino acid, n is
included between 1 and 3, and R.sub.2.dbd.H or an alkyl chain having a carbon length of between
C.sub.2 and C.sub.22.
Appl: 20050153862
System and process for releasing encapsulated active ingredients
The present invention relates to a controlled release system that can be incorporated in cosmetic,
personal care, and household products to effectively encapsulate wide range of active ingredients
and sensory markers and release them in response to moisture or over an extended period of time.
The controlled release system of the present invention consists of oil absorbing polymer
nanospheres coated with water sensitive surface active polymers.
Appl: 20050175649
Enhancing properties by the use of nanoparticles
Composite materials comprising nanoparticles functionalized with metals are disclosed. The
composite materials may be used in a variety of applications, including in coating compositions,
cosmetic and pharmaceutical compositions, absorbent articles, and the like.
Appl: 20050182461
Shape-adaptable and spectral-selective distributed light sources using passive host medium
A method of making shape-adaptable and spectral-selective distributed optical radiation sources, in
the wavelength range between UV and mid-infrared, for therapeutic treatment using passive host
medium containing nanocrystals is disclosed. The spectral output of the distributed optical radiation
source is controlled by the nanocrystal size distribution that determines the spectral output of
fluorescence radiation originating from these nanocrystals from within the said host medium, which
contains the said nanocrystals, under excitation by an external source. The size of nanocrystals, or
the size distribution of nanocrystals, incorporated in the host medium is selected based on the
radiation spectral output required for therapeutic requirements. The passive host medium,
incorporating the said nanocrystals, is made of adaptable, geometrically configurable, material that
conforms to any desired shape.
Appl: 20050199415
Flame retardant and smoke suppressant composite high performance support-separators and conduit
tubes
The present invention includes a high performance communications cable exhibiting reduced crosstalk of any form between transmission media that includes one or more core support-separators
having various shaped profiles which define a clearance to maintain a spacing between
transmission media or transmission media pairs. The core may be formed of a conductive or
insulative material to further reduce cross-talk and improve other electrical properties as well as
reduce flame and smoke spread. The cable and separators are comprised of principally polymer
blends that include olefin and/or fluoropolymer and/or chlorofluoropolymer based resins with and
without inorganic additive such as nano-clay composites. These unique blends offer both flame and
smoke suppression while maintaining the characteristics necessary to improve electrical
performance and allow for severe cost reduction over conventional separators. The specially shaped
core support-separators can be either interior to the cable jacket or be employed singularly without
the benefit of a jacket and extend along the longitudinal length of the communications cable.
Alternatively, with no jacket for cable completion, a portion of the separator wherein a thin layer of
material can act as a type of skin for future mechanical protection is provided. The specially shaped
core support-separator has both a central region as well as a plurality of shaped sections that extend
outward from the central region that are either solid or partially solid, foamed or foamed with a
solid skin surface. In addition, the invention includes the optional incorporation of hollow ducts
that can be used to provide optical or metal conductor media either before, during, or after
installation of the cable primarily by gas driven means.
Appl: 20050202075
Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers
Receptor-specific nanocontainers are used to deliver a gene that encodes short hairpin RNA to cells
having a given receptor. Once inside the cell, the gene expresses short hairpin RNA that includes a
nucleotide sequence that is antisense to at least a portion of an oncogene, such as human epidermal
growth factor receptor (EGFR) mRNA, or other disease causing nucleotide sequence. The short
hairpin RNA is converted, in the cellular cytoplasm, into short RNA duplexes that are effective in
deactivating (knocking down) the oncogenic or disease causing gene.
Appl: 20050208282
Co-extruded biaxially oriented sealable, peelable film and process for its production
A peelable sealable co-extruded film, comprising: i. a skin layer capable of heat sealing against a
rim of a container, to itself, or to another film and adapted to be peeled there from and comprising a
hot melt adhesive resin; and ii. a core layer underlying said skin layer and comprising crystalline
homopolymer polyethylene terephthalate; and a method for the preparation thereof.
Appl: 20050220829
Healthcare and cosmetic compositions containing nanodiamond
Nanodiamonds can be included in various compositions to take advantage of the ability of
nanodiamond to bond with biological materials and to improve mechanical strength.
Nanodiamonds can be dispersed in a biologically acceptable carrier to form various nanodiamond
compositions. The presence of nanodiamonds can increase binding with many biological materials,
making the compositions of the present invention useful for a large variety of purposes such as
cleansing, testing and identification of materials, and treatment of adverse conditions. Specific
examples of nanodiamond compositions that can be formulated include deodorants, toothpastes,
shampoos, antibiotics, dermal strips, DNA test strips, skin cleansers, and the like. Similarly,
nanodiamond particles can be included in a cosmetic nanodiamond composition within a
cosmetically acceptable carrier. Cosmetic nanodiamond compositions can include, for example,
nail polish, eyeliner, lip gloss, exfoliant, and the like.
Appl: 20050221519
Semiconductor light emitting devices including a luminescent conversion element and methods for
packaging the same
Methods of packaging a semiconductor light emitting device include dispensing a first quantity of
encapsulant material into a cavity including the light emitting device. The first quantity of
encapsulant material in the cavity is treated to form a hardened upper surface thereof having a
selected shape. A luminescent conversion element is provided on the upper surface of the treated
first quantity of encapsulant material. The luminescent conversion element includes a wavelength
conversion material and has a thickness at a middle region of the cavity greater than proximate a
sidewall of the cavity.
Appl: 20050222071
Topical administration of at least one double-stranded RNA oligonucleotide (dsRNA)
Expression of a messenger RNA which encodes a protein which is expressed by differentiated
cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to
said differentiated cells a thus effective amount of at least one double-stranded RNA
oligonucleotide, formulated into a topically applicable, physiologically acceptable medium
therefor; such regime or regimen is useful for treating a variety of afflictions or conditions, e.g.,
combating the signs of skin aging, stimulating hair growth or retarding loss thereof, inhibiting
cellular proliferation and/or differentiation, etc.
Appl: 20050229328
Nano-particles on fabric or textile
Systems and methods for fabricating a wash durable material includes forming a substrate having
strands with void spaces in the strands and between the strands; filling at least a part of the void
spaces with nano-particles; and forming projections on the substrate.
Appl: 20050232955
Cosmetic compositions containing small magnetic particles
The present invention present a novel and cost-effective family of cosmetic compositions
comprising inter alia small magnetic particles characterized by magnetic field adapted to be
topically administrated adjacent to skin surface, absorbed to epidermal upper skin layers and place
in a direct contact to the body, usually above pain suffering regions. The present invention also
provides the use of the compositions, especially of nano-powders of salts obtained from the Dead
Sea, as an external layer of bandages, dressings, compresses or warps, so constantly approached to
be in an intimate contact with the patient's skin.
Appl: 20050244522
Permeation enhancer comprising genus Curcuma or germacrone for transdermal and topical
administration of active agents
A formulation, method and system for the topical, transdermal or transmucosal administration of a
therapeutically effective active agent. Particularly, the invention provides a formulation, system and
method for enhancing the permeation or penetration of active agents across the dermal or mucosal
surfaces of a mammalian subject. The formulation includes a plant extract of the genus Curcuma of
the family Zingiberaceae, a germacrone, or a natural or synthetic constituent thereof, which has
been found to increase penetration of the active agent across the dermal or mucosal surface. If
desired, a secondary permeation enhancer of a polyalcohol, a monoalkyl ether of diethylene glycol,
a tetraglycol, or a mixture thereof can be used for certain active agents for optimal permeation
enhancement.
Appl: 20050249760
Human body affinitive lubricating protective and repair gel
The present invention discloses a human body affinitive lubricating protective and repair gel, which
combines photocatalyst (TiO.sub.2) particles with a disinfection material such as nano silver to
produce a TiO.sub.2Ag compound, and mixes the compound with a filtered natural biological
organism with a molecular weight below 50 Kbp and a concentration of 0.05.about.5% including
small molecules of collagen, chitin, chitosan, hyaluronic acid, vitamin C, and nano iron, and its pH
value is adjusted to 6 which is close to the pH value of our skin, and thus the mixture constitutes a
gel affinitive to human skins and non-toxic to human cells. An accessory ingredient such as an
aromatic agent, a detergent, or a cosmetic agent is added in the manufacturing process to produce
an emulsion or a paste for coating or spraying, which is used as a health or sanitation item such as a
hand liquid soap, a cosmetic, a shampoo, or a disinfectant. The feature of the small diameter of the
particles (1.about.100 n/m) can penetrate the cuticle of our skin and remain at the derma inside the
skin pores to produce a protective film, and the collagen can be absorbed by the skin to give the
effects of repairing tissues, stopping bleeding, and lubricating skins. With the cyclic disinfection
effect of the TiO.sub.2Ag compound, a deeper clean skin to prevent germs is obtained and a
disinfection effect is achieved to eliminate acnes and pimples. The present invention also makes
use of an oxidation-reduction mechanism of the photocatalyst (TiO2) to achieve long-hour
disinfection and naturally remove germs.
Appl: 20050255057
Appl: 20050255606
Methods for accurate component intensity extraction from separations-mass spectrometry data
The present invention discloses methods for deconvolving and converting 1D mass spectra to 2D
mass spectrum in order to obtain migration time centers and total intensities of the neutral mass
envelopes of 2D spectra. The present invention also discloses devices that include a
preparation/separation unit coupled to a mass spectrometer unit, and a computer unit capable of
deconvolving mass spectra and calculating neutral mass envelopes.
Appl: 20050282148
Artificial immune system: methods for making and use
The present invention relates to methods of constructing an integrated artificial immune system that
comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the
normal tissues that interact with vaccines in mammals. The artificial immune system can be used to
test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development
and testing drug and chemical interaction with the immune system.
Appl: 20050287225
Metal cluster nano-compounds for treating tumor diseases
The invention relates to metal cluster nano-compounds of transition metals, which includes a metal
nucleus formed from atoms of at least one transition metal and at least one ligand, and including
their physiologically compatible salts, derivatives, isomers, hydrates, metabolites and prodrugs,
which are suited for the prophylactic and/or therapeutic (curative) treatment of diseases of the
human or animal body, particularly of tumor or cancer diseases. To this end, the inventive
compounds can, under physiological conditions, interact with the DNA, preferably B-DNA, of the
relevant cells.
Appl: 20060029977
Detection and quantification of prion isoforms in neurodegenerative diseases using mass spectrometry
Disclosed are methods, compositions and kits for diagnosing prion-mediated pathological
conditions and presence of aberrant prion protein in animal derived products, utilizing mass
spectrometry.
Appl: 20060034786
Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin
appendages
Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole,
styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2This document was prepared by www.FormulaScan.com. Its reproduction in any type of form or format is strictly prohibited without
thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin
and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening
of the skin and/or skin appendages, notably for preventing and/or limiting canities.
Appl: 20060045917
Method of conveying matter into targeted cells in a human body
A method of conveying matter to targeted cells in a human body, including the steps of providing a
predetermined amount of substance desired to be conveyed to the human body, embracing the
substance with a predetermined amount of carrier to form a nano-size dosage form and
administrating the nano-size dosage form to the human body. The carrier is capable of traveling
around the human body through the nervous system of the human body along with the substance
desired to be conveyed. The substance to be conveyed includes a wide range of substances such as
medication, food supplements, or vitamins. The method conveys matters that are especially useful
in curing illnesses or diseases. Even when used alone, the carrier helps curing illnesses or diseases.
Appl: 20060069068
Methods and compositions for the treatment of diseases characterized by pathological calcification
Methods and compositions are provided which contains preparations of calcium chelators,
bisphosphonates, antibiotics, antimicrobial agents, cytostatic agents, calcium ATPase and
pyrophosphatase pump inhibitors, calcium phosphate-crystal dissolving agents, agents effective
against calcium phosphate-crystal nucleation and crystal growth, and/or a combination of
supportive agents and which may be used for treating and or reducing pathological calcifications,
the growth of Nanobacterium and calcification-induced diseases including, but not limited to,
Arteriosclerosis, Atherosclerosis, Coronary Heart Disease, Chronic Heart Failure, Valve
Calcifications, Arterial Aneurysms, Calcific Aortic Stenosis, Transient Cerebral Ischemia, Stroke,
Peripheral Vascular Disease, Vascular Thrombosis, Dental Plaque, Gum Disease (dental pulp
stones), Salivary Gland Stones, Chronic Infection Syndromes such as Chronic Fatigue Syndrome,
Kidney and Bladder Stones, Gall Stones, Pancreas and Bowel Diseases (such as Pancreatic Duct
Stones, Crohn's Disease, Colitis Ulcerosa), Liver Diseases (such as Liver Cirrhosis, Liver Cysts),
Testicular Microliths, Chronic Calculous Prostatitis, Prostate Calcification, Calcification in
Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma,
Dermatomyositis, Antiphospholipid Syndrome, Arteritis Nodosa, Thrombocytopenia, Hemolytic
Anemia, Myelitis, Livedo Reticularis, Chorea, Migraine, Juvenile Dermatomyositis, Grave's
Disease, Hypothyreoidism, Type 1 Diabetes Mellitus, Addison's Disease, Hypopituitarism,
Placental and Fetal Disorders, Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as
Corneal Calcifications, Cataracts, Macular Degeneration and Retinal Vasculature-derived Processes
and other Retinal Degenerations, Retinal Nerve Degeneration, Retinitis, and Iritis), Ear Diseases
(such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and Inner
Ear (Vertigo and Tinnitus)), Thyroglossal Cysts, Thyroid Cysts, Ovarian Cysts, Cancer (such as
Meningiomas, Breast Cancer, Prostate Cancer, Thyroid Cancer, Serous Ovarian Adenocarcinoma),
Skin Diseases (such as Calcinosis Cutis, Calciphylaxis, Psoriasis, Eczema, Lichen Ruber Planus),
Rheumatoid Arthritis, Calcific Tenditis, Osteoarthritis, Fibromyalgia, Bone Spurs, Diffuse
Interstitial Skeletal Hyperostosis, Intracranial Calcifications (such as Degenerative Disease
Processes and Dementia), Erythrocyte-Related Diseases involving Anemia, Intraerythrocytic
Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive Pulmonary Disease,
Broncholiths, Bronchial Stones, Neuropathy, Calcification and Encrustations of Implants, Mixed
Calcified Biofilms, and Myelodegenerative Disorders (such as Multiple Sclerosis, Lou Gehrig's and
Alzheimer's Disease) in humans and animals. The method comprises administering the various
classes of compositions of the present invention, which together effectively inhibit or treat the
development of calcifications in vivo.
Appl: 20060069069
Methods and compositions for the administration of calcium chelators, bisphosponates and/or citrate
compounds and their pharmaceutical uses
A composition is provided which contains calcium chelators, bisphosphonates, and/or citrate
compounds and which may be used for treating and or reducing pathological calcifications, heavy
metal poisoning, the growth of Nanobacterium Calcifying Nano-Particles and calcification-induced
diseases in humans and animals. The method includes administering a therapeutic composition of
calcium chelators, bisphosphonates, and/or citrate compounds which effectively inhibit or treat the
development of calcifications in vivo. Typically, the administered composition includes about 0.110:1 parts by weight of calcium chelators, bisphosphonates, and/or citrate compounds.
Appl: 20060079179
Short-distance wireless transmission device for driving functions of medical equipment
A short-distance wireless transmission device for driving functions of medical equipment, the
short-distance wireless transmission device includes a data converting module and a signal emitting
module integrated in an electronic product. As such, a user can input a control command via the
electronic product, by means of the data converting module, the control command is converted into
a common format data, and within an effective distance, a control signal is subsequently
transmitted by the signal emitting module via a wireless transmission approach to medical
equipment having therein a signal receiving module, thereby allowing the user to control and adjust
medical equipment provided on his/her body in real time via a portable electronic communication
product in the short-distance wireless transmission approach.
Appl: 20060083727
Methods and compositions for the treatment of diseases characterized by calcification and/or plaque
formation
The invention provides methods and compositions that include a nutraceutical supplement,
antibiotic, and metal chelating agent that is administered to a patient to treat or prevent pathological
calcification and or plaque formation as associated with Nanobacteria Calcifying Nano-Particles
and/or diseases caused there-from, The method includes the administration of a therapeutically
effective nutraceutical supplement, tetracycline HCL, and ethylenediaminetetraacetic acid calcium
di-sodium salt to a patient in order to prevent and treat calcific disease.
Appl: 20060099146
NIR-sensitive nanoparticle
It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIRsensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at
least one surfactant selected from: wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of
R.sup.1, R.sup.2, R.sup.3 and R.sup.4, if present, is H, substituted or unsubstituted C.sub.1-C.sub.6
alkyl, substituted or unsubstituted C.sub.1-C.sub.6 aryl, HS, COOH, NH.sub.2 or OH; R.sup.5 is
COOH, NH.sub.2 or OH; with the proviso that n+m is <10; (b) an amino acid having the structure
in (a), wherein X=1; Y=2; Z=1; W=1; R.sup.1, R.sup.2 and R.sup.4 are not present; R.sup.3 is
NH.sub.2; and R.sup.5 is COOH; or (c) a peptide, wherein the peptide comprise at least one amino
acid (b). Further, it is provided a NIR-sensitive nanoparticle complex(es) having biomolecule(s),
for example drug(s), loaded on the surfactant(s).
Appl: 20060099405
Polymer-fiber composite building material with bulk and aesthetically functional fillers
Polymer composite building materials are provided which contain resin, and about 20-75 wt. %
fillers and additives, in which the fillers contain at least one bulk filler for reducing the amount of
resin needed to make the building material, and at least one aesthetically functional filler for
providing the building material with an aesthetic appearance. The bulk filler and the aesthetically
functional filler of this embodiment are non-toxic, resistant to microbial attack, and have a Mohs
hardness of less than about 5.
Appl: 20060110343
Cosmetic or dermopharmaceutical compositions comprising tyramine derivatives, method for preparing
same, and use thereof
The invention concerns cosmetic or dermopharmaceutical compositions comprising tyramine
derivatives and their salts. The invention also concerns the method for preparing same and use
thereof for reducing pigmaentation.
Appl: 20060110413
Novel Molecules dervied from noraporphine
Appl: 20060165643
Cosmetic or dermopharmaceutical compositions containing kombucha
Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The
present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical
compositions containing the same, alone or in combination, for the care of the skin, mucosae and
skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.
Appl: 20060167526
Medical apparatus and system for preventing and treating diseases
Medical apparatus and system are provided for preventing and treating diseases by the medical
apparatus comprising body-thing, electronic pulse device, medical magnet slices, herbal medicine
gauze pads and nano-micro-biochemical-textile. The medical apparatus is made in various types
such as cap, eyeshade, waistband, knee-band, wristband based on different position of human body.
The medical apparatus and system are effective and safe for preventing and treating diseases such
as headache, migraine, eyestrain, nervosas, insomnia, forgetful, overweight, hypertension, diabetes,
cerebral thrombosis, cervical spondylosis, lumbago and seraglio, rheumatoic arthritis,
scapulohumeral periarthritis.
Appl: 20060182770
COSMETIC AND COSMECEUTICAL COMPOSITIONS FOR RESTORATION OF SKIN BARRIER
FUNCTION
Appl: 20060188573
Composite materials and particles
A method or concept for producing a composite material having at least an amphifilic (i.e., surfaceactive) and polymer component, and the composite material formed thereby, includes providing a
mixture of at least one each of polymer and amphifilic compound in a volatile solvent or solvent
mixture and providing a phase diagram of the chemical system describing how the components of
the chemical system interact in thermodynamic stable phases as a function of temperature,
concentration and pressure. The polymer should be a homopolymer, a random block copolymer or
a mixture thereof, preferably biodegradable. The amphifilic compound can form a bilayercontaining phase. The solvent is removed from the mixture by a process selected from the phase
diagram considering the desired final composite material, whereby a material is formed. The
composite material is useful for applications such as encapsulation of therapeutically active
components or for applications such as surface coating.
Appl: 20060235471
Biological chip
A biological chip provided for maintaining the health of a body cell through maintaining an
original electrical signal expressed by the body cell, wherein the biological chip comprises a power
source, a communication chip, and a biological carrier. The communication chip contains a
correcting electrical signal, which is adapted for assisting the unhealthy body cell. The biological
carrier forms a communication channel between the communication chip and the unhealthy body
cell for transmitting the correcting electrical sign to the unhealthy body cell, so as to restore the
unhealthy body cell back to the healthy condition. The correcting electrical signal corrects an
unhealthy electrical signal transmitted by the cell without affecting healthy electrical signals
transmitted by other healthy cells, such that the correcting electrical signal helps restoring the
healthy condition of a cell, healing wounds, curing infections and converting harmful mutated cells
to normal body cells, so as to cure diseases such as cancers and AIDS effectively. The biological
chip is applied to a body in a transdermal manner such that no ingestion or injection of medication
is required.
Appl: 20060237217
Variable diameter conduit tubes for high performance, multi-media communication cable
The present invention describes a conduit tube like structure for high performance, multi-media
communications cables with or without support separators that are of varying internal and external
dimensions and wall thicknesses that may vary consistantly or randomly and may be spirally or
helically wound within or around a high performance, multi-media communications cable to vary
the spacing between a high performance, multi-media communications cable and an adjacent
communications cables to mitigate alien cross talk as well as the influence of EME/RFI. The
conduit tube structures say be hollow, contain communications media, solid, comprised of various
shapes, and wrapped with various windings and/or tensions. The final cable assembly may then be
jacketed or taped as desired.
Appl: 20060237218
High performance, multi-media cable support-separator facilitating insertion and removal of conductive
media
The present invention includes a high performance communications cable support-separator that
exhibits reduced cross-talk of any form between transmission media that includes one or more core
support-separators having various shaped profiles which define a clearance to maintain a spacing
between transmission media or transmission media pairs. The cable channels have longitudinal
gaps that allow for improved insertion and removal of conductive transmission media to aid in
terminating and connecting the transmission media. The cable support-separator channel
intermediary may be additionally separated from each other.
Appl: 20060237219
Concentric-eccentric high performance, multi-media communications cables and cable supportseparators utilizing roll-up designs
The present invention includes a high performance communications cable or cable supportseparator and/or jacket that provides reduced cross-talk of any form between transmission media
and includes one or more core support-separators having various shaped profiles which define a
clearance to maintain spacing between transmission media or transmission media pairs. The core
may be formed of a conductive or insulative material to further reduce cross-talk and improve other
electrical properties as well as reduce flame and smoke spread. The cable and separators may be
comprised of polymer blends that include olefin and/or fluoropolymer and/or chlorofluoropolymer
based resins with and without inorganic additives such as nano-clay composites, C.sub.60 based
compounds, etc. These unique blends offer both flame and smoke suppression while maintaining
the characteristics necessary to improve electrical performance and allow for severe cost reduction
compared with conventional separators. Alternatively, with no jacket for cable completion, a
portion of the separator wherein a thin layer of material can act as a type of skin for future
mechanical protection is provided. The specially shaped core support-separator has both a central
region as well as a plurality of shaped sections that extend outward from the central region that are
either solid or partially solid, foamed or foamed with a solid skin surface. In addition, the invention
includes the optional incorporation of hollow ducts that can be used to provide for insertion of
optical or metal conductor media either before, during, or after installation of the cable. In the case
where insertion occurs after installation, the installation primarily utilizes gas driven means.
Appl: 20060237221
High performance, multi-media communication cable support-separators with sphere or loop like ends
for eccentric or concentric cables
The present invention includes a communications cable support-separator that has both a central
region as well as a plurality of shaped sections that extend outward from the central region having
various shaped profiles on the ends that are either solid or partially solid, foamed or foamed with a
solid skin surface and that exhibits reduced cross-talk of any form between transmission media.
Included is one or more end profiles which define a clearance to maintain a spacing between
transmission media or transmission media pairs. The core may be comprised of principally polymer
blends including olefin, fluoropolymer, chlorofluoropolymer based resins or combinations with and
without inorganic additive such as nano-clay composites or conductive or insulative material. The
specially shaped core support-separators can be either interior to a cable jacket or be employed
singularly without the benefit of a jacket and extend along the longitudinal length of the
communications cable.
Appl: 20060246242
Packaging articles, films and methods that promote or preserve the desirable color of meat
Food packaging articles, food packaging films, and food packaging methods comprising a
myoglobin blooming agent that promote or preserve the desirable appearance of food products are
provided. The food contact layer of the packaging films comprises a myoglobin blooming agent.
Appl: 20060249889
Production and use of a sacrificial mold core for metal casting
The manufacture and use of sacrificial molds for metal casting, in particular for sacrificial molds of
green ceramic. For production of the ceramic cast mold one frequently resorts to slip-casting in
which the shaping of the mold is brought about by casting of liquid slip into the original mold.
Bubbles or blisters frequently occur in this casting, which in the later mold lead to not tolerable
surface and joint faults of the mold. This can only partially be counteracted by employment of socalled boosting and careful pouring. It is thus the task of the invention to provide a process for
production of mold cores of slip ceramic for metal casting, in which the problem of bubbles or
blisters is at least reduced. The invention is solved by using a porous original mold. This provides
the advantage, that enclosed or trapped air bubbles or blisters can escape through the pores of the
original mold, while the slip on the basis of its surface tension cannot penetrate into the pores.
Appl: 20060264804
Device and kit for delivery of encapsulated substances and methods of use thereof
The present invention is of a kit and electricity generating device for delivery of an encapsulated
composition or mixture of compositions, including an electricity generating device and at least one
composition in an encapsulated carrier vehicle which is contacted or applied to the electricity
generating device. In some embodiments the device includes a means for maintaining stability of
the encapsulated composition prior to bio-membrane penetration. The present invention also
provides methods of use thereof. Furthermore, the present invention provides a device and method
for delivering a fixed ratio of compounds from a mixture to a bio-membrane comprising the step of
electro-transporting an encapsulated mixture of compounds. Still further, the present invention is of
a device and method for delivering each compound of a mixture of compounds to the same
penetration depth.
Appl: 20060267156
Electrospray and enhanced electrospray deposition of thin films on semiconductor substrates
A method of forming a thin film on a substrate to fabricate a microelectronic device, a
microelectronic device comprising a thin film deposited according to the method, and a system
comprising the microelectronic device. The thin film may include on of a low k thin film, a thin
film comprising photoresist, and a sacrificial polymer. The method comprises dispersing a
precursor preparation into a spray of charged droplets through subjecting the liquid precursor
preparation to electrostatic forces; directing the charged droplets to move toward the substrate; and
allowing the charged droplets to generate a beam of gas-phase ions as the charged droplets move
toward the substrate. The method further includes directing the gas-phase ions to impinge upon the
substrate to deposit the thin film thereon to yield a deposited thin film on the substrate.
Appl: 20060275368
Biocompatible polymer
The present disclosure relates to a biocompatible polymer composition for an article comprising a
surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids,
body fluids, dialysis fluids, therapeutic fluids, or mixtures thereof for removal or infusion. The
invention also relates to a method for the preparation of an article comprising the biocompatible
polymer composition and a use thereof.
Appl: 20060286323
Myoglobin blooming agent, films, packages and methods for packaging
Non-shrink, forming and nonforming thermoplastic webs comprising a myoglobin blooming agent
on a food contact surface are useful for packaging fresh meat and other products to fix a desirable
color on the surface of the product.
Appl: 20070003501
Vectorization of dsRNA by cationic particles and use of same on a skin model
The present invention relates to vectorization of double stranded RNA oligonucleotides by cationic
particles chosen from among surfactant micelles, block or non-block polymer micelles, cationic
liposomes and niosomes, cationic oleosomes and cationic nanoemulsions, as well as from among
cationic organic or inorganic particles and nanocapsules, and to the use of compositions comprising
the association of at least one dsRNA and at least one cationic particle on skin models.
Appl: 20070010831
Biomimetic biosynthetic nerve implant
A biomimetic biosynthetic nerve implant (BNI) that uses a hydrogel-based, transparent, multichannel matrix as a 3-D substrate for nerve repair is disclosed. Novel scaffold-casting devices were
designed for reproducible fabrication of grafts containing several micro-conduits, and further tested
in vivo using a sciatic nerve animal model and repair of the adult hemitransected spinal cord. At 16
weeks post-injury of the sciatic nerve, empty tubes formed a single nerve cable. In sharp contrast,
animals that received the multi-luminal BNI showed multiple nerve cables within the available
microchannels, better resembling the multi-fascicular anatomy and ultra structure of the normal
nerve. In the injured spinal cord, the BNI loaded with genetically engineered Schwann cells were
able to demonstrate survival of the grafted cells inside the BNI, and robust axonal regeneration
through the implant up to 45 days after repair.
Appl: 20070014953
Webs with synergists that promote or preserve the desirable color of meat
Food packaging articles, food packaging webs, and food packaging methods comprising a
myoglobin blooming agent and synergist that promote or preserve the desirable appearance of food
products are provided. The food contact layer of the packaging webs may comprise a myoglobin
blooming agent and a synergist.
Appl: 20070032572
OPTICALLY CLEAR NANOCOMPOSITES AND PRODUCTS USING NANOSCALE FILLERS
Methods for preparing nanocomposites that enable films with optical clarity, wear resistance and
superior functional performance. Nanofillers and a substance having a polymer are mixed. Both
low-loaded and highly-loaded nanocomposites are included. Nanocomposite films may be coated
on substrates.
Appl: 20070043109
Slimming cosmetic composition
Cosmetic or dermopharmaceutical compositions containing, in a dermatologically acceptable
carrier, at least one diterpene among: cafestol, kahweol and chemical derivatives are useful for
slimming treatments including prevent and/or treat cellulite or orange peel and/or to refine contours
of the face, skin firming, to reduce the steatomery of the thighs, to decrease the volume/fatty
overload of the spare tire at the hips, to reduce "love handles", both on men and women.
Appl: 20070048296
Methods and compositions for the treatment of diseases characterized by calcification and/or plaque
formation
The invention provides methods and compositions that include a nutraceutical supplement,
antibiotic, and metal chelating agent that is administered to a patient to treat or prevent pathological
calcification and or plaque formation as associated with Nanobacteria Calcifying Nano-Particles
and/or diseases caused there-from, The method includes the administration of a therapeutically
effective nutraceutical supplement, tetracycline HCL, and ethylenediaminetetraacetic acid calcium
di-sodium salt to a patient in order to prevent and treat calcific disease.
Appl: 20070053960
Multiribbon nanocellulose as a matrix for wound healing
The present invention includes compositions and methods for the integration of a non-allergenic
nanocellulose into a wound bed. The composition may be formed into a wide variety of implants,
e.g., a suture, a sheet, a compress, a bandage, a band, a prosthesis, a fiber, a woven fiber, a bead, a
strip, a clasp, a prosthesis, a catheter, a screw, a bone plate, a pin, a bandage or combinations
thereof.
Appl: 20070072793
Histone hyperacetylating agents for promoting wound healing and preventing scar formation
A method for promoting wound healing and preventing scar formation in a variety of wounds in
skin, mucosa, and cornea. The method comprises administering a therapeutically effective amount
of a histone deacetylase inhibitor or a hyperacetylating agent. The histone deacetylase inhibitor or
hyperacetylating agent is capable of stimulating multiple cytokines/growth factors in the early
phase of wound healing, and suppressing fibrogenic cytokines/growth factors in the late phase of
tissue remodeling in the wound site, and is useful in promoting epithelial cell re-growth and
reducing excessive collagen accumulation, which results in rapid wound closure with reduced
scaring.
Appl: 20070073197
Assessment and control of acoustic tissue effects
A method for reversibly, or irreveribly, altering the permeability of cells, tissues or other biological
barriers, to molecules to be transported into or through these materials, through the application of
acoustic energy, is enhanced by applying the ultrasound in combination with means for monitoring
and/or implementing feedback controls. The acoustic energy is applied directly or indirectly to the
cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter
the permeability to achieve the desired effect, such as the transport of endogenous or exogenous
molecules and/or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of
cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In
the preferred embodiment, the method includes measuring the strength of the acoustic field applied
to the cell or tissue at the applied frequency or other frequencies, and using the acoustic
measurement to modify continued or subsequent application of acoustic energy to the cell or tissue.
In another preferred embodiment, the method further includes simultaneously, previously, or
subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or
across the cell or tissue. In another preferred application, the method includes removing biological
fluid or molecules from the cell or tissue simultaneously, previously or subsequently to the
application of acoustic energy and, optionally, assaying the biological fluid or molecules.
Appl: 20070092546
Thiamin based insect repellant
The present invention provides a topical application of thiamin to human skin or mammalian coats
to provide effective insect repellency. Any commercially available thiamin compounds such as
thiamin hydrochloride or thiamin mononitrate can be combined with a pharmaceutically or
cosmetically acceptable carrier for preparing a composition for topical application. This
composition and method of application can further be combined with sun-block or sunscreen agents
to provide protection against insects as well as the harmful effects of UV radiation. This
composition may also contain botanical oils or extracts to mask the thiamin odor and provide
repellant synergy.
Appl: 20070092575
Compositions for administering RNAIII-inhibiting peptides
Compositions comprising RIP are advantageously formulated in compositions allowing sustained
release and protection from degradation, and improved therapeutic efficacy. To that end, RIP
compositions may be delivered to the skin or mucosal membranes as a salve or the like.
Alternatively or additionally, RIP compositions may be administered in polymeric nanoparticle
carriers, which may be biodegradable. Such formulations are compatible with oral administration.
The nanoparticle may accommodate a composition comprising a RIP and at least one other
antimicrobial agent, e.g., an antibiotic or an antimicrobial peptide. The nanoparticle further may
comprise a coating or moiety, such as an antibody or fragment thereof, to assist in cell targeting.
Appl: 20070095475
ADHESIVE MATERIAL AND METHOD OF USING SAME
An adhesive and/or activatable (e.g., heat expandable and/or curable) material and articles
incorporating the same are disclosed. The material includes an epoxy resin, an epoxy/elastomer
hybrid or reaction product or both; a blowing agent, a curing agent or both; and optionally, a filler.
Appl: 20070099842
Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure
The invention relates to compounds and to the cosmetically acceptable salts thereof, which
correspond to general formula (I), wherein: R.sup.1 represents H, --C(O)--R.sup.6, --SO.sub.2-R.sup.6 or --C(O)--XR.sup.6; R.sup.2 and R.sup.4, independent of one another, represent
(CH.sub.2).sub.n--NH.sub.2 or (CH.sub.2).sub.3--NHC(NH)NH.sub.2; n equals 1 4; R.sup.3
represents linear or branched C.sub.1-C.sub.4 alkyl that is optionally substituted by hydroxy;
R.sup.5 and R.sup.6, independent of one another, represent hydrogen, optionally substituted
(C.sub.1-C.sub.24) alkyl, optionally substituted C.sub.2-C.sub.24 alkenyl, optionally substituted
phenyl, optionally substituted phenyl-C.sub.1-C.sub.4 alkyl or 9-fluorenyl-methyl; X represents
oxygen (--O--) or --NH--; or XR.sup.5 with X=O also represents the esters of a-tocopherol,
tocotrienol or retinol, with the provision that R.sup.1 and R.sup.5 do not represent hydrogen and X
does not represent oxygen at the same time. The invention also relates to the production of the
compounds of general formula (I) and to a cosmetically active composition that contains at least
one compound of formula (I).
Appl: 20070100358
A Biomimetic Synthetic Nerve Implant
A biomimetic biosynthetic nerve implant (BNI) that uses a hydrogel-based, transparent, multichannel matrix as a 3-D substrate for nerve repair is disclosed. Novel scaffold-casting devices were
designed for reproducible fabrication of grafts containing several micro-conduits, and further tested
in vivo using a sciatic nerve animal model and repair of the adult hemitransected spinal cord. At 16
weeks post-injury of the sciatic nerve, empty tubes formed a single nerve cable. In sharp contrast,
animals that received the multi-luminal BNI showed multiple nerve cables within the available
microchannels, better resembling the multi-fascicular anatomy and ultra structure of the normal
nerve. In the injured spinal cord, the BNI loaded with genetically engineered Schwann cells were
able to demonstrate survival of the grafted cells inside the BNI, and robust axonal regeneration
through the implant up to 45 days after repair.
Appl: 20070104901
Method for distributing a myoglobin-containing food product
A method of distributing or commercializing fresh meat having the general steps of butchering a
slaughtered animal into a plurality of retail cuts; packaging the retail cuts into a plurality of articles
wherein each article comprises a polymeric oxygen barrier film having a transparent portion in
contact with at least a portion of the fresh meat product; transporting the packaged article to a retail
outlet, wherein the packaged article is adapted for retail display and sale without removing the
polymeric film and wherein the fresh meat product has a desirable appearance especially a
desirable red color e.g. having an "a*" value of at least about 15 for the fresh beef product or of at
least about 6 for a fresh pork or fresh poultry product and the color is maintained for at least five
days and up to four weeks or more after display.
Appl: 20070111306
SYSTEMS AND METHODS FOR SELECTION AND MAINTENANCE OF HOMOGENEOUS AND
PLURIPOTENT HUMAN EMBRYONIC CELLS
A number of human disorders are characterized by degeneration or loss of specific cells, resulting
in pathology associated with reduction or absence of cell function. Such diseases include
neurodegenerative diseases and diabetes. Methods are described for obtaining a substantially
homogeneous population of undifferentiated human embryonic stem cells including incubating a
population of human embryonic stem cells with an amount of a selection agent. The selection agent
is effective to reduce or eliminate differentiated embryonic stem cells from the population of cells
such that a substantially homogeneous population of undifferentiated human embryonic stem cells
is obtained. The substantially homogeneous population of undifferentiated embryonic stem cells
may be produced without use of feeder cells.
Appl: 20070116401
METHOD, SYSTEM AND MODULE FOR MONITORING A POWER GENERATING SYSTEM
A sensing module positioned about an optical fiber cable having a long axis. The optical fiber
includes a core that transmits light through the optical fiber cable. The sensing module includes a
first short-period fiber grating positioned about the core. A second short-period fiber grating is
positioned about the core and at a distance along the long axis with respect to the first short-period
fiber grating. At least one of a long-aperiod fiber grating and a long-period fiber grating is
positioned between the first short-period fiber grating and the second short-period fiber grating. A
fiber cladding is positioned around the long-period grating and/or the long-aperiod grating of the
sensing module. A sensing skin is positioned about the fiber cladding and includes a chemical gas
active material.
Appl: 20070118040
Pulsimeter sensor using magnetic thin films
The present invention relates to a noninvasive medical pulsimeter sensor using magnetic thin films.
By forming a pulse-sensing part array with magnetic sensors such as GMR devices, MTJ devices
and the likes, over the skin-contacting part which consists of a magnetic material, the present
invention increases the integrity of sensors, minimizes the time for searching the pulse and it is
applicable widely to portable pulsimeters and the likes.
Appl: 20070134188
Double-stranded RNA oligonucleotides which inhibit tyrosinase expression
Novel double-stranded RNA oligonucleotides are useful for decreasing tyrosinase expression, have
cosmetic and/or pharmaceutical applications, for example are useful skin depigmenting or antibrowning agents, and can be associated with cationic particles less than or equal to 1 .mu.m in size,
having a zeta potential of from 10 to 80 mV.
Appl: 20070134814
Methods and compositions for the detection of calcifying nano-particles, identification and quantification
of associated proteins thereon, and correlation to disease
Disclosed are methods and compositions for detecting, analyzing and assessing the significance of
calcifying nano-particles. The disclosed methods and compositions generally involve detecting one
or more proteins present on a calcifying nano-particle. It has been discovered that particular
proteins become associated with calcifying nano-particles. This association provides a means for
detecting, classifying, analyzing, categorizing, and assessing calcifying nano-particles. Detecting
particular proteins while associated with a calcifying nano-particle can be used to indicate the
presence and type of calcifying nano-particle, which can be used to indicate the presence of, or
disposition to, diseases or conditions. Multiple proteins on a calcifying particle can be detected.
The presence or absence of particular proteins and the pattern of the presence and absence of
particular proteins can be used to indicate the presence and type of calcifying nano-particle.
Appl: 20070135335
Therapeutic molecules
The present invention relates generally to a ligand for a protein associated with modulating obesity,
diabetes and metabolic energy levels in animals including humans. More particularly, the present
invention provides a ligand of the protein, Beacon, and its homologs. The identification of a
Beacon ligand permits the identification of agents which agonize or antagonize the Beacon-ligand
interaction and, hence, the development of therapeutic molecules useful in modulating obesity,
diabetes and/or energy imbalance.
Appl: 20070140951
Nano-sized particles, processes of making, compositions and uses thereof
The present invention describes methods for preparing high quality nanoparticles, i.e., metal oxide
based nanoparticles of uniform size and monodispersity. The nanoparticles advantageously
comprise organic alkyl chain capping groups and are stable in air and in nonpolar solvents. The
methods of the invention provide a simple and reproducible procedure for forming transition metal
oxide nanocrystals, with yields over 80%. The highly crystalline and monodisperse nanocrystals are
obtained directly without further size selection; particle size can be easily and fractionally increased
by the methods. The resulting nanoparticles can exhibit magnetic and/or optical properties. These
properties result from the methods used to prepare them. Also advantageously, the nanoparticles of
this invention are well suited for use in a variety of industrial applications, including cosmetic and
pharmaceutical formulations and compositions.
Appl: 20070141055
Methods and compositions for protein-hydroxy apatite complexes and their application in testing and
modulating immunological system including a novel in vitro test for the detection of antibodies against
calcium binding protein-hydroxy apatite complexes
The invention relates to methods and compositions for the manufacture and use of novel hydroxy
apatite (HA)-calcium binding protein (CaBP) complexes (CaBP-HA complex) that are useful as
antigen preparations for immunological assays for the diagnosis, prognosis, and monitoring of
mammalian diseases. The CaBP-HA complexes may be manufactured using synthetic HA that is
subjected to serum proteins or by harvesting nanobacteria (NB), also called calcifying nanoparticles (CNP), from a mammal. The hydroxy apatite is prepared by incubation with appropriate
proteins resulting in conformational changes in said bound proteins. Secondary conformational
changes occur when said CaBP-HA complex is subjected to enzymes such as transglutaminase
thereby creating covalently bound neoepitopes. The CaBP-HA complex may also contain
lipopolysaccharide binding protein (LPSBP) providing for anti-CaBP-LPSBP-HA antibodies
detection indicative of disease. Detection of anti-CaBP-HA antibodies in a mammal is via enzyme
linked immunosorbent assay.
Appl: 20070148219
Liposomal Nanowater-Containing Patch-Type Nanodermal Gel for Transdermal Delivery and Method
for Preparing the Same
Disclosed herein is a patch-type nanodermal gel including liposomal nanowater, which can deliver
cosmetically active substances, such as those functioning to moisturize the skin, into and through
the skin stably and effectively. The patch-type cosmetic composition for transdermal deliver, based
on nanodermal gel, comprises nanowater in an amount from 0.01 to 80.0% by weight; a skincompatible polymer in an amount from 0.01 to 10.0% by weight; and a polyhydric alcohol in an
amount from 5.0 to 20.0% by weight, based on the total weight of the nanodermal gel.
Appl: 20070154771
Highly conductive composites for fuel cell flow field plates and bipolar plates
This invention provides a fuel cell flow field plate or bipolar plate having flow channels on faces of
the plate, comprising an electrically conductive polymer composite. The composite is composed of
(A) at least 50% by weight of a conductive filler, comprising at least 5% by weight reinforcement
fibers, expanded graphite platelets, graphitic nano-fibers, and/or carbon nano-tubes; (B) polymer
matrix material at 1 to 49.9% by weight; and (C) a polymer binder at 0.1 to 10% by weight;
wherein the sum of the conductive filler weight %, polymer matrix weight % and polymer binder
weight % equals 100% and the bulk electrical conductivity of the flow field or bipolar plate is at
least 100 S/cm. The invention also provides a continuous process for cost-effective mass
production of the conductive composite-based flow field or bipolar plate.
Appl: 20070167517
Stabilized derivatives of ascorbic aicd
Ascorbic acid derivatives of the general formula 1: wherein R<1> is a C2-C22 acyl group, an
amino acid group, or a C1-C17 alkyl group; R<2> is ammonium or a metal cation; and each of
R<3> or R<4>, independently, is hydrogen, a C2-C22 acyl group, an amino acid residue, or a C1C17 alkyl group, are more stable than ascorbic acid and can be used as a source of vitamin C in
pharmaceutical, nutraceutical and cosmetic compositions.
Appl: 20070181913
Integrated Circuit Device
A commercially mass-produced, integrated circuit including: a solid substrate of one conductivity
type; at least one solid material pocket of a different conductivity type having a side surface and
positioned on a selected top surface of the substrate to thereby form a signal-translating, electronic
rectifying barrier between the at least one solid material pocket and the selected top surface of the
substrate; and a solid state material region adjoining the substrate, the electronic rectifying barrier,
and the side surface of the at least one solid material pocket; wherein next to the electronic
rectifying barrier the solid state material region has a lateral dimensional accuracy of better than a
few hundred atomic layers.
Appl: 20070184121
nanodiamond to reduce or prevent the formation of free radicals through administering the particles
to a subject. Nanodiamonds can be administered through a variety of means to a tissue area of the
subject, thus reducing or preventing the formation of free radicals and reducing the signs of ageing.
The nanodiamonds may be incorporated into a composition that includes a variety of components
including biologically or cosmetically acceptable carriers, dispersants, and additional active
ingredients.
Appl: 20070203534
Stimulating galvanic or slow AC current for therapeutic physiological effects
Basically, the present invention is directed to a new and improved system for the therapeutic use of
currents which includes conducting direct electrical current through the skin of a body being
treated, and periodically reversing the electrical current and conducting the current through the skin
in the opposite direction, to effectively deliver very low frequency AC current, substantially in the
critical range of approximately 0.0027 Hz to 20 Hz. It has been discovered that, within this
substantially critical frequency window between approximately six minutes per full cycle and
approximately ten cycles per second, a dramatic cancellation of skin damaging ions takes place. At
frequencies higher than approximately 20 Hz, the effect is to diminish its DC-like blood
stimulation. At frequencies lower than approximately 0.0027 Hz, the risk of skin injury increases
substantially. It is well known that the positive electrode unfortunately produces skin damaging
hydrochloric acid. Likewise, the negative electrode unfortunately also produces skin damaging
sodium hydroxide. However, within the aforementioned frequency range of the present invention,
either polarity stimulates blood circulation, but also cancels the undesired skin damaging ions with
the reverse portion of the electrical cycle. The reason for neutralization of the harsh injury
producing chemicals, i.e., hydrochloric acid and sodium hydroxide, is that both of these chemicals
require a finite period of time on the skin to cause damage. Hence, these damaging chemicals are
made to cancel each other before damage takes place, by critical frequency selection, in accordance
with the invention, of the AC driving signal. Therefore, optimization of a long sought
electrotherapeutic device with reduced side effects has been achieved. Another use of the safe AC
currents cited above and/or a DC signal with charged membranes preventing injury is its
application to wound healing. The conductive electrodes for these devices may take either of two
forms, i.e., one may be non-metallic carbon-filled silicone or, preferably of powdered carbon
particles. A second form may be a metallic electrode preferably of aluminum, copper, zinc and/or
magnesium as examples of metallic electrodes but not necessarily limited to these metals. These
metals are preferably in powdered form and contained within a porous membrane with a small
opening to attach a conductive lead to a battery source. Still other applications of the innovative use
in electrotherapy of charged membranes and/or powdered metal electrodes is its use for drug
delivery and diagnostic purposes. For instance, a membrane enclosed stainless steel powdered
negative electrode may be used in the pickup probe for glucose detection. Charged membranes
would surround the probe as an intervenor between skin and the electrode.
Appl: 20070207101
Cosmetic Compositions Comprising Sub-micron Boron Nitride Particles
A cosmetic composition for use on hair, skin or nails, containing a safe and effective amount of
boron nitride powder has been found which improves the appearance of skin by blurring lines and
wrinkles while at the same time providing coverage of age spots, blemishes and other
discolorations.
Appl: 20070237800
MULTIPHASIC BIOFUNCTIONAL NANO-COMPONENTS AND METHODS FOR USE THEREOF
Multiphasic nano-components (MPNs) having at least two phases and at least one active ingredient
are provided. The MPNs can be used in various methods for medical diagnostics or with
pharmaceutical, personal care, oral care, and/or nutritional compositions, for example, in oral care,
hair, or skin products. The MPNs can be designed to have targeted delivery within an organism,
while providing controlled release systems or combining incompatible active ingredients. Further,
the MPNs can be used as biomedical coatings (such as anti-microbial coatings), or anti-corrosive
coatings, bioimaging probes with combined diagnostic and therapeutic use, and fragrance release
systems, among others. The MPNs can be formed by electrified jetting of polymers.
Appl: 20070238953
Combined ultrasonic imaging and spectroscopic molecular analysis
The invention provides an apparatus for combined imaging and analyzing of a biological structure
by means of ultrasonic and spectroscopic techniques. The inventive diagnostic apparatus is adapted
for simultaneous acquisition of ultrasonic echo signals and surface enhanced Raman spectroscopic
signals. The invention makes particular use of a contrast agent that on the one hand provides
enhanced reflection efficiency for ultrasonic echo signals and on the other hand enables surface
enhanced Raman spectroscopy. The contrast agent comprises conventional microbubbles as well as
solid metal nano-particles or combinations thereof. The invention therefore effectively provides
non-invasive in vivo analysis of blood as well as detection and visualization of a blood flow.
Appl: 20070243259
Nanoparticles for protein/peptide delivery and delivery means
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile
bombardment as a carrier for administering proteins or peptides to an animal subject. The
nanoparticles are composed of positively charged shell substrate, negatively charged core substrate
with encapsulated bioactive agents of proteins or peptides.
Appl: 20070267022
Secure nano-mask
A face mask made of woven or non-woven material that accommodates the anatomical features of
the face. It has a nose recess or nose-locating space, extended chin space and close fitting cheek
areas, for use in medical environments or for general public use. The mask has been developed with
innovations that provide security to the wearer by its to the fitting the face particularly without
moving upwards or downwards when moving the jaw. This is unlike all other masks tested which
either move upwards to reveal the mouth or slide downward to reveal the nostrils due to the
movement of the jaw and face when talking or coughing etc. The stability and secure fit to the face
is achieved by following the anatomical configuration of the face and by the positioning of the
slightly elastic holding straps--the upper one is positioned level with the upper nose to the top of
the ear and the lower strap from the mid point of the mask to under the ear--the straps form a loop
around the ear. The forces and vectors of the whole mask are directed around the balance point of
the mask such that any the movement of the mask in one direction is countered by forces in the
other. Furthermore the mask provides protection against cross-contamination and infection by
incorporating a nanotechnology anti-microbial component that holds and kills membrane-bound
organisms, as well as protecting the wearer against pollen and similar allergens.
Appl: 20070286856
Modulation of Hyaluronan Synthesis and Degradation in the Treatment of Disease
The present invention provides compositions and methods for modulating the expression of
Hyaluronan (HA). In particular, this invention relates to compounds, which hybridize with nucleic
acid molecules encoding hyaluronan synthase (HAS), particularly HAS isoforms HAS1, HAS2 and
HAS3. These compounds may range in size from oligonucleotides to full length sequences. Such
compounds are exemplified to modulate proliferation, such as cancer and inflammatory disorders,
such as arthritis. It will be understood, however, that the compounds can be used for any other
condition in which HA is involved.
Appl: 20070292773
NANO IMPRINT MASTER AND METHOD OF MANUFACTURING THE SAME
A nano imprint master and a method of manufacturing the same are provided. The method
includes: implanting conductive metal ions into a substrate including quartz to form a conductive
layer inside the quartz substrate; coating a resist on the quartz substrate in which the conductive
layer is formed, to form a resist coating layer; exposing the resist coating layer to an electron beam
to form micropatterns; etching the quartz substrate by using the resist coating layer, in which the
micropatterns are formed, as a mask; and removing the resist coating layer to obtain a master in
which micropatterns are formed.
Appl: 20070293799
Nano-silver wound dressing
A nano-silver wound dressing consists of a skin contact layer made from hydrophilic cloth and
directly contacting wound on surface of skin, a disinfecting (or bactericidal) antitoxic layer made
from activated charcoal cloth impregnated with nanocrystalline silver, a blood absorbing and
styptic layer made from non-woven cloth with superabsorbent polymer, an isolation layer made
from composite fabric with pore size less than 5 .mu.m, and an elastic bandage for fixing a main
body on the site of wound. Edges of the isolation layer and the skin contact layer are integrated to
form a main body while the disinfecting (or bactericidal) antitoxic layer as well as the blood
absorbing and styptic layer are separated from each other and both enclosed inside the main body.
Appl: 20070299420
DELIVERY OF AN AGENT USING IONTOPHORESIS
A method and apparatus for delivering an agent to structures of the eye or other body sites using
iontophoresis applied through the eyelid, skin, etc. of a patient. A drug is introduced into the eye or
other body site. A first electrode is in electrical communication with the site and a second electrode
is positioned in relation to the first electrode. The electrodes are energized to generate a current
between the electrodes and through the site that facilitates the selective dissemination of the agent
throughout the eye or site.
Appl: 20080004559
Multi-Component Dressing for Wound Treatment on the Human or Animal Body with Application of
Reduced Pressure
The invention relates to a multi-component dressing (100) for treating wounds of the human or
animal body using a reduced pressure, having a wound-covering element (4) for mounting the
dressing (100) at the surface of the skin and the mucous membrane and at least one connecting site
(5), which is in contact with the wound space (10) and over which the materials in the wound space
(10) can be evacuated. The multi-component dressing has super-absorbing polymers, the absorbed
wound secretions remaining bound to polymers in the wound space until the latter are removed
from the wound space and the polymers, due to their binding capacity, supporting reciprocal
synergies with the sub-atmospheric pressures. Wound exudate, promoted by the reduced pressure,
is also stored and controlled by polymerized granulates.
Appl: 20080009812
Device for the Treatment of Wounds Using a Vacuum
The invention relates to a device (100) for treating wounds of the human or animal body using a
vacuum and having a gas-tight wound-covering element (4), which, when placed in contact with
the body of the patient, forms a wound space (10) between the respective wound and the woundcovering element, at least one connecting site (5.1; 5.2), which is in contact with the wound space
(10), an absorption body (2), which is a layer, enclosed in an envelope, of a textile section,
interspersed with super-absorbing particles, the envelope being permeable to liquids and having
pores, the size of which does not exceed that of the super-absorbing particles. The absorption body
(2), which is to be inserted in the wound space (10), has an initial volume, which enlarges in the
course of the absorption process, and a final volume, so that, due to the size of the pores of the
envelope, the absorbed wound secretions remain within the absorption body (2) and, with that,
below the wound-covering element, until the absorption body is removed from the wound space.
Appl: 20080014278
METAL-CONTAINING FORMULATIONS AND METHODS OF USE
Metal-containing materials, as well as their preparation, formulations, and use are disclosed.
Appl: 20080016819
Nano-composite door facings, and related door assemblies and methods
A door skin adapted for construction of a door assembly is provided. The door skin is embodied as
a rectangular solid sheet having interior and exterior opposing surfaces. The solid sheet contains a
polymeric material and a nanocomponent. Also provided are door assemblies, and related methods.
Appl: 20080018015
Method of Producing Fibers by Electrospinning at High Pressures
A process of making fibers by electrostatic spinning includes the use of a mixing vessel (10), a
piston (15) for pressurizing the polymer, carbon dioxide sources (20) for lowering the viscosity of
the polymer or pressurizing the collection vessel (35), a pressure generator (25), view ports (30), a
target (36), a spinning needle (40), a camera/TV recorder (45) and a voltage source (50).
Appl: 20080019975
Novel Regimens for Treating Diseases and Disorders
Methods and materials are provided for induction-maintenance regimens of targeted antiinflammatory therapies (TATs) for treatment of a variety of diseases and disorders. Preferred
embodiments include administration of one or more TATs using an induction regimen comprising a
lower dose per administration administered by a more invasive and/or more localized route,
followed by administration of one or more TATS using a maintenance regimen, comprising a
higher dose per administration administered by a less invasive and/or less localized route.
Appl: 20080021519
Communication Unit for a Person's Skin
Electric communication unit to be placed on a person's skin, comprising a support element (3), a
series of body contacts (7), a pulse generator (6) provided for generating a series of pulses and for
transmitting the series of pulses to said series of body contacts (7), said series of body contacts (7)
being provided to transmit said series of pulses onto the skin of said person. The electric
communication unit is in the form of a patch.
Appl: 20080029147
Stacked Layer Electrode For Organic Electronic Devices
An electrode for an electro-optic device has a wetting layer of electrically conductive material
formed on a substrate. A second layer of electrically conductive material is formed on the wetting
layer of electrically conductive material. The wetting layer has a first wetting ability with respect to
a surface of the substrate and the second layer has a second wetting ability with respect to the
surface of said substrate. The first wetting ability is different from the second wetting ability and
the wetting layer acts to alter an optical property of the electrode due to the wetting ability of the
wetting layer on the surface of the substrate.
Appl: 20080039769
METHOD OF MEDICAL TREATMENT USING CONTROLLED HEAT DELIVERY
The present invention relates to a system for treating a patient. The system includes a device
configured to be positioned adjacent a portion of the patient, a medicinal substance delivery device,
adapted to delivery a medicinal substance to the portion of the patient, a heating means adapted to
provide heat to the device and a control system configured to monitor the heating means and
control the temperature of the device at the portion of the patient.
Appl: 20080039907
Phototherapy Systems and Methods
A phototherapy method includes applying to skin a lotion which includes a carrier material and
nanocrystals located in the carrier material, and exposing the lotion to photons of a first wavelength
range such that the nanocrystals convert the photons of a first wavelength range into photons of a
second wavelength range suitable for phototherapy and provide the photons of the second
wavelength range to the skin.
Appl: 20080044444
Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent,
selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer
selected from the group consisting of at least one surface-active agent; at least one polymeric agent
and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a
hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures
thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that
is substantially resistant to aging and to phase separation and or can substantially stabilize other
active ingredients. The invention further relates to a foamable composition further containing a
liquefied hydrocarbon gas propellant.
Appl: 20080050452
METAL-CONTAINING FORMULATIONS AND METHODS OF USE
Metal-containing materials, as well as their preparation, formulations, and use are disclosed.
Appl: 20080061192
METHOD AND APPARATUS FOR MITIGATING TRAILING VORTEX WAKES OF LIFTING OR
THRUST GENERATING BODIES
This patent provides for a method and apparatus for mitigating the formation of concentrated wake
vortex structures generated from lifting or thrust-generating bodies and maneuvering control
surfaces wherein the use of contour surface geometries promotes vortex-mixing of high and low
flow fluids. The method and apparatus can be combined with various drag reduction techniques,
such as the use of riblets of various types and/or compliant surfaces (passive and active). Such
combinations form unique structures for various fluid dynamic control applications to suppress
transiently growing forms of boundary layer disturbances in a manner that significantly improves
performance and has improved control dynamics.
Appl: 20080103459
ENZYME INHIBITION USING NANOPARTICLES
Methods and compositions useful for the inhibition of enzyme activity, including in the treatment
of enzymatic dermatitis, are provided. Such compositions comprise a composite material
comprising: (a) an exfoliated nanoparticle having a surface and (b) a metal selected from Groups 3
to 12, aluminum and magnesium, wherein the metal is loaded onto the surface of the nanoparticle.
Appl: 20080112914
COMPOSTION FOR SKIN EXTERNAL USE CONTAINING OMEGA-3 FATTY ACID
Stable preparations containing omega-3 fatty acid as an effective ingredient are disclosed. Further,
uses of omega-3 fatty acid in preventing or alleviating skin aging, moisturizing skin, improving
skin roughness, restoring or strengthening skin barrier function, improving skin elasticity,
recovering or preventing skin damage induced by UV are disclosed.
Appl: 20080115846
Aqueous fluid photoprotective compositions comprising ester-terminated poly(ester amide) polymers
Enhanced SPF and/or reduced fluffing fluid compositions for photoprotecting the skin and/or the
hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective
system capable of screening out UV radiation; and (b) at least one ester-terminated poly(ester
amide) (ETPEA) polymer, formulated into (c) a topically applicable, cosmetically acceptable
aqueous support therefor; the subject aqueous compositions are advantageously vaporizable,
especially in the form of sprays, confined within a pressurization device.
Appl: 20080115890
Methods and systems for using molecular-film adhesives
Various embodiments of the present invention are directed to molecular-film adhesives and
methods and systems for using molecular-film adhesives. In one embodiment of the present
invention, an amphipathic, biological-substrate-compatible adhesive is applied as a molecular-film.
The amphipathic adhesive includes a first functional group, capable of bonding to a first substrate,
and a second functional group, capable of bonding to a second, chemically dissimilar substrate.
Appl: 20080118563
Preparation of Chitin and Derivatives Thereof For Cosmetic and Therapeutic Use
The invention relates to novel chitin derivatives and their use in medical treatments of plastic
surgery, dermocosmesis and therapy, in particular it relates to natural chitin derivatives, like chitin
in nanofibrillar form, oxychitin and other chemical derivatives of chitin, chitosan-hyaluronate and
associations for use as subcutaneous fillers or skin protectants.
Appl: 20080128044
MOISTURE-MANAGEMENT IN HYDROPHILIC FIBERS
Provided is a fabric having improved moisture-management performance and being resilient to
repeated washing, as well as a process for manufacturing the fabric. The process, employing
consecutive steps of hydrophilization and hydrophobization, includes defatting cotton or cellulose
fibers and their coating with silicone nanoparticles.
Appl: 20080132135
Extensible nonwoven webs containing multicomponent nanocomposite fibers
The present invention provides nonwoven webs comprising multicomponent nanocomposite fibers
that enable the nonwoven webs to possess high extensibility. The multicomponent nanocomposite
fibers comprise two or more components. Each component comprises a polymer composition and
at least one component comprises a nanoparticles composition. The nonwoven webs comprising the
multicomponent nanocomposite fibers have an average elongation at peak load which is greater
than the average elongation at peak load of comparable nonwoven webs without nanocomposite
fibers.
Appl: 20080132862
Extensible nonwoven webs containing monocomponent nanocomposite fibers
The present invention provides nonwoven webs comprising monocomponent nanocomposite fibers
that enable the nonwoven webs to possess high extensibility. The monocomponent nanocomposite
fibers comprise a polymer composition and a nanoparticles composition. The nonwoven webs
comprising the monocomponent nanocomposite fibers have an average elongation at peak load
which is greater than the average elongation at peak load of comparable nonwoven webs without
nanocomposite fibers.
Appl: 20080136775
Virtual input device for computing
A virtual input device or apparatus that replaces the typical mouse, keyboard or other finger
manipulated inputs currently used as inputs for any type of computing system such as signals used
to control computers, PDAs, Video Games, Multimedia Displays and other similar electronic
systems whether of a desktop or mobile configuration.
Appl: 20080138296
Foam prepared from nanoemulsions and uses
The present invention provides a foamable composition for administration to the skin, body
surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory
system, vagina or rectum. The foamable oil in water nano emulsion composition includes: (a) a
nano oil globule system, comprising substantially of sub-micron oil globules; (b) about 0.1% to
about 5% by weight of at least one stabilizing agent, selected from the group consisting of (i) a
non-ionic surfactant, (ii) an ionic surfactant, and (iii) a polymeric agent; and (c) a liquefied or
compressed gas propellant at a concentration of about 3% to about 25% by weight of the total
composition, water and optional ingredients are added to complete the total mass to 100%. Upon
release from an aerosol container, the foamable composition forms and expanded foam suitable for
topical administration. The present invention further provides methods of treating, alleviating or
preventing a disorder of the skin, body cavity or mucosal surface using such foamable
compositions; and to methods of producing such foams having an improved bubble size.
Appl: 20080138379
Methods, treatments, and compositions for modulating Hedgehog pathways
The present invention relates to prevention of congenital deformations The invention further relates
to cancer inhibition and prevention. The invention further relates to methods and compositions to
modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate
patterning events gene expression during prenatal development, post-natal development and during
development in the adult organism.
Appl: 20080139911
SELF-ADHERING ELECTRODES AND METHODS OF MAKING THE SAME
A self-adhering sensor for non-invasively attaching to a portion of a skin is provided. The sensor
comprises a biocompatible substrate, and an array of solid nanoelectrodes coupled to the
biocompatible substrate and configured to self-adhere to the skin. Also provided is a sensor for
attaching to a portion of a skin, where the sensor comprises an array of solid electrodes configured
to self-adhere to the skin, where each of the solid structures comprises a stem and one or more
projections extending out from the stem, where both the stem and the projections are solid. The
stem comprises a mechanical stopper to control the extent of penetration of the solid electrodes into
the skin. The sensor further comprises an electrolyte coating disposed on one or more of the solid
structures.
Appl: 20080139993
USE OF NANOPARTICLES IN THE PHOTODYNAMIC TREATMENT OF TUMORS AND NONDESTRUCTIVE TESTING
A method for generating light intensity inside a tumor to aid in the treatment of diseases such as
cancer is disclosed. The light is generated inside the body to perform a modified photodynamic
therapy treatment (PDT) that allows treatment of body regions that are inaccessible by normal PDT
procedures. In addition, the use of two spatially and temporally coincident treatment modalities, i.e.
radiation and PDT, have the potential for significant biological synergy in the tumor.
Appl: 20080146478
ENCAPSULATED ACTIVE MATERIAL CONTAINING NANOSCALED MATERIAL
The present invention is directed to novel capsules containing active material and nanoscaled
material and to methods for making capsules with enhanced performance and stability. The
capsules are well suited for use in personal care applications, laundry products and perfume and
fragrance products.
Appl: 20080163670
METHODS AND SYSTEMS FOR MONITORING STRUCTURES AND SYSTEMS
Methods and systems for passenger monitoring and system control is provided. The system
includes at least one sensor system configured to monitor an environment immediately surrounding
the respective passenger and biometrics of the respective passenger and generate sensor data
indicative of a state of the passenger. The system also includes a processing system configured to
receive the sensor data. The processing system includes an ontology and reasoning module
configured to model at least one of the plurality of passengers, reason about the received sensor
data associated with the at least one of the plurality of passengers. The processing system also
includes a contextual analyzer configured to transmit the received sensor data to said ontology and
reasoning module and to store the information into a contextual information database.
Appl: 20080166303
Colored or colorable foamable composition and foam
There is described a colored or colorable topical composition, comprising: a) a foamable base
composition comprising, 1) a flowable carrier composition; 2) a color agent; wherein the color
agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from
the foamable composition and wherein the color agent is one or more agents selected from the
group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a
dye, a colorant and a coloring agent; b) a propellant at a concentration of about 3% to about 25% by
weight of the total composition; wherein the base composition has a first color; and wherein the
foam comprising the colored or colorable topical composition has a second color upon dispensing
from an aerosol container, and wherein the first color and the second color are visually different.
There is also described a method of changing color, a method of administration, a use as a
diagnostic and a kit.
Appl: 20080166382
AMPHIPHILIC BLOCK COPOLYMERS AND NANOPARTICLES COMPRISING THE SAME
An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or
more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The
invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for
delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.
Appl: 20080181919
SHIUNKO NANOMICELL FOR SKIN TREATMENT AND PREPARATION METHOD FOR THE
SAME
The present invention provides a nanomicell for a skin, and the nanomicell includes an oil
substance, an extract of a Angelica Radix, an extract of a Lithospermum Radix, and a phospholipid
layer. The extract of a Angelica Radix is formed by extracting the Angelica Radix with the oil
substance, and the extract of a Lithospermum Radix is formed by extracting the Lithospermum
Radix with the oil substance. The extract of the Angelica Radix and the extract of the
Lithospermum Radix are packaged within the phospholipid layer to form a plurality of micells
having a diameter of nano-level.
Appl: 20080183250
Compositions and methods for treating or preventing skin inflammation via restoration of skin barrier
function
Compositions, kits and methods are provided for restoring skin barrier function to skin of a subject
after a medical or a cosmetic procedure. In general, a composition containing divalent cations such
as calcium ions and/or magnesium ions in a physiologically acceptable medium can be used to
treat, inhibit or prevent inflammation of skin post medical, demertological, or cosmetic procedure
such as chemical peeling, laser skin resurfacing, microdermabrasion, plasma energy treatment,
radiofrequency treatment, hair or vein removal or lightening, skin treatment using light energy or
photofacial, thereby treating, inhibiting or preventing post-inflammatory hyperpigmentation of the
skin or other skin disorders.
Appl: 20080187575
Pyrimidine Derivatives
The present invention relates to pyrimidine derivatives, methods for their synthesis, and the use of
said pyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or
treatment of cell proliferation disorders, cancer, leukemia, erectile dysfunction, cardiovascular
diseases and disorders, inflammatory diseases, transplant rejection, immunological diseases,
neuroimmunological diseases, autoimmune diseases, infective diseases including opportunistic
infections, prion diseases and/or neuro-degeneration. Furthermore, the present invention relates to
pharmaceutical compositions containing at least one pyrimidine derivative and/or pharmaceutically
acceptable salts thereof as an active ingredient together with at least one pharmaceutically
acceptable carrier, excipient or diluents as well as to methods for prophylaxis and/or treatment of
the above-mentioned diseases and disorders.
Appl: 20080193566
Use of high dose concentrations of gaseous nitric oxide
The invention relates to a methods and devices of delivering gaseous nitric oxide to a mammal or
surface at a concentration ranging from about 1000 ppm to about 50,000 ppm of gaseous nitric
oxide. Different conditions which can be treated by high dosage administration of gNO include but
are not limited to: topical treatments with gNO, cosmetic applications of gNO, vasodilation
conditions with gNO, inhalation treatments with gNO, treatments of the blood with gNO, treatment
of the skin or tissue with gNO, treatment of infections with gNO, treatment of inflammation on or
within the body, and treatments of biofilms with gNO. Other conditions, aliments, or symptoms
that may be treated with high dosage gNO include bronchoconstriction, reversible pulmonary
vasoconstriction, asthma, pulmonary hypertension, adult respiratory distress syndrome (ARDS),
and persistent pulmonary hypertension of the newborn (PPHN).
Appl: 20080195071
Absorbent Article With Barrier Sheet
The present invention is directed to an absorbent article having a backsheet, an absorbent core and
cuffs and/or a topsheet, the topsheet being provided with at least one opening adapted to receive
fecal material, the cuffs or topsheet comprising a nonwoven sheet material, comprising typically at
least two nonwoven layers, the layers being typically only partially attached to one another and
each comprising typically two or more nonwoven webs that are laminated together, whereof the
skin-contacting nonwoven layer or web has a specific low bending rigidity, whilst the nonwoven
sheet as a whole has a very high barrier function.
Appl: 20080195186
CONTINUOUS CONDUCTIVE MATERIALS FOR ELECTROMAGNETIC SHIELDING
A medical electrical lead having a conductor assembly covered by an insulating layer, and a shield
covering positioned adjacent or proximate to at least a portion of the insulating layer in order to
shield the conductor assembly from one or more electromagnetic fields. The shield covering is
formed of a material that is electrically conductive, where the material is in a wrapped or woven
form. The material is selected so as to have an effective combination of small size and high
conductive surface area, e.g., as opposed to metal wire or coatings thinner than metal wire. As such,
the shield covering exhibits sufficient conductivity in the presence of one or more high frequency
electromagnetic fields so that interference to the operation of the conductor assembly is minimized.
The material can have a coating formed of one or more metals. The material can include carbon. In
turn, the carbon can be formed of one or more of carbon fiber, carbon nanofiber, and single or
multi-walled carbon nanotube.
Appl: 20080195187
DISCONTINUOUS CONDUCTIVE FILLER POLYMER-MATRIX COMPOSITES FOR
ELECTROMAGNETIC SHIELDING
A medical electrical lead having a conductor assembly covered by an insulating layer, and a shield
covering positioned adjacent or proximate to at least a portion of the insulating layer in order to
shield the conductor assembly from one or more electromagnetic fields. The shield covering is
formed of a polymer-matrix composite. The polymer-matrix composite includes a polymeric resin
having discontinuous conductive fillers provided therein. The discontinuous conductive fillers
include one or more of nano-sized metal structures and nano-sized non-metallic conductive
structures. The nano-sized non-metallic conductive structures can have a coating formed of one or
more metals. The nano-sized non-metallic conductive structures can be formed of carbon. In turn,
the nano-sized non-metallic conductive structures can include one or more of carbon nanofibers,
carbon filaments, carbon nanotubes, and carbon nanoflakes.
Appl: 20080206349
Spray Dried Compositions
The invention provides a method comprising the steps of: (i) providing an emulsion of: a) an
aqueous solvent, such as water, b) a carrier material dispersible or soluble in (a), said carrier
material being solid at ambient temperature, and preferably being a polymer and inorganic salt or a
surfactant, c) a volatile second liquid phase (for example, chloroform) which is not miscible with
(a), and d) a material which is dispersible or soluble in (c) but not in (a), and, (ii) Drying the
emulsion at above ambient temperature (preferably by spray drying) to simultaneously remove (a)
and (c) and thereby obtain the material (b) in solid form with (d) dispersed therein.
Appl: 20080206362
DEVICE AND METHOD FOR INCREASING BLOOD FLOW AND INSULIN-LIKE GROWTH
FACTOR
In order to provide a device and a method for increasing blood flow and an insulin-like growth
factor with use of a large amount of carbonic gas nano bubbles, the device of the present invention
includes: a bathtub 1; and a nano bubble-producing section 41 for producing carbonic gas nano
bubbles in bath water in the bathtub 1.
Appl: 20080207774
ANIONIC LATEX AS A CARRIER FOR ACTIVE INGREDIENTS AND METHODS FOR MAKING
AND USING THE SAME
This invention relates to the field of polymeric materials that can be used in combination with a
wide variety of substrates, such as personal care products, textiles, metal, cellulosic materials,
plastics, and the like, and to the field of active agents including, for example, antimicrobial,
antibacterial and antifungal materials. This invention further relates to latex polymer coatings that
comprise at least one active component as well as methods for making and using such latex
compositions.
Appl: 20080212230
WAVEGUIDE STRUCTURE, MANUFACTURING METHOD THEREOF AND HAMR USING THE
SAME
A manufacturing method of a waveguide structure includes forming a metal layer of a
predetermined size on a substrate to form a structure, forming a lower clad layer on the structure in
order to completely cover the metal layer, forming a core layer of a predetermined size on the lower
clad layer at the location corresponding to the metal layer, and forming an upper clad layer thereon
in order to completely cover the core layer.
Appl: 20080213179
Differentially Expressed Nucleic Acids in the Blood-Brain Barrier Under Inflammatory Conditions
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression
is modulated in brain microvascular endothelial cells undergoing early dynamic inflammationinduced changes in blood-brain barrier functionality. Such polypeptides are referred to as
lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides
may be useful in methods for controlling blood-brain barrier properties in mammals in need of such
biological effects. This includes the diagnosis and treatment of disturbances in the bloodbrain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders.
Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as
diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use
of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic
probes, therapeutic agents or drug delivery enhancers.
Appl: 20080213198
Cosmetic or Dermopharmaceutical Composition Comprising at Least one Udp Glucuronosyl Transferase
(Ugt) Enzymes Inducer
The invention relates to topical use of at least one UGT inducer for the preparation of a cosmetic or
dermopharmaceutical composition comprising a dermatologically acceptable carrier to protect
and/or enhance the state of the skin and prevent and/or treat imperfections of the skin.
Appl: 20080214913
Surface-Enhanced Spectroscopy with Implanted Biosensors
The present invention provides a spectroscopic apparatus, a method and a computer program
product for determining the concentration of an analyte of a fluid that flows through a capillary
vessel of a biological sample. The spectroscopic apparatus makes use of an imaging system for
determining the position of at least one biosensing substrate that has been implanted into the
biological sample in the proximity of the capillary vessel but outside the capillary vessel. The
biosensing substrate is capable of inducing surface-enhanced spectroscopic effects and is preferably
adapted to reversibly and selectively bind a certain analyte or molecule of the fluid, to which the
vessel wall of the capillary vessel is at least semi-permeable. By performing a spectroscopic
analysis not directly inside the capillary vessel but in close proximity to the capillary vessel, the
signal-to-noise ratio of the spectroscopic signals obtained can be appreciably enhanced while
disadvantageous scattering and interference effects can be minimized.
Appl: 20080214987
Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
A system and method of using a high-aspect ratio microdevice for treating, preventing or
ameliorating a medical condition is provided.
Appl: 20080220026
Mesoporous material compositions and methods of their use for improving the appearance of biological
surfaces
The present invention relates to compositions and methods for treating and improving the aesthetic
appearance of a biological surface by altering the optical properties of the biological surface,
thereby resulting in a natural appearance. The compositions of the invention may be topically
applied to the biological surface, including but not limited to skin, in an amount effective in
improving the aesthetic and natural appearance of the biological surface.
Appl: 20080226684
METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND
RELEASING SYSTEMS
The present invention includes compositions, methods, systems and kits for the controlled delivery
of an active agent within a polymeric network upon the binding of a molecule that decreases the
structural integrity of the polymeric network at one or more micro- or nanovacuoles.
Appl: 20080243094
BATHTUB APPARATUS, THERAPEUTIC BATHTUB APPARATUS, BATHING WATER AND
THERAPEUTIC BATHING WATER
A bathtub apparatus is provided, including a nanobubble and/or nanosized medical component
generating section to combine at least either of nanobubbles or a nanosized medical component
with bath water from a bathtub and to circulate the bath water to the bathtub.
Appl: 20080248005
Isolation and Cultivation of Stem/Progenitor Cells From the Amniotic Membrane of Umbilical Cord and
Uses of Cells Differentiated Therefrom
The present invention relates to a skin equivalent and a method for producing the same, wherein the
skin equivalent comprises a scaffold and stem/progenitor cells isolated from the amniotic
membrane of umbilical cord. These stem/progenitor cells may be mesenchymal (UCMC) and/or
epithelial (UCEC) stem cells, which may then be further differentiated to fibroblast and
keratinocytes. Further described is a method for isolating stem/progenitor cells from the amniotic
membrane of umbilical cord, wherein the method comprises separating the amniotic membrane
from the other components of the umbilical cord in vitro, culturing the amniotic membrane tissue
under conditions allowing cell proliferation, and isolating the stem/progenitor cells from the tissue
cultures. The invention also refers to therapeutic uses of these skin equivalents. Another aspect of
the invention relates to the generation of a mucin-producing cell using stem/progenitor cells
obtained from the amniotic membrane of umbilical cord and therapeutic uses of such mucinproducing cells. In yet another aspect, the invention relates to a method for generating an insulinproducing cell using stem/progenitor cells isolated from the amniotic membrane of umbilical cord
and therapeutic uses thereof. The invention further refers to a method of treating a bone or cartilage
disorder using UCMC. Furthermore, the invention refers to a method of generating a dopamin and
tyrosin hydroxylase as well as a HLA-G and hepatocytes using UCMC and/or UCEC. The present
invention also refers to a method of inducing proliferation of aged keratinocytes using UCMC.
Appl: 20080255570
BONE TREATMENT SYSTEMS AND METHODS
Systems and methods for delivering bone cement into a bone can include a handle body defining a
flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the
flow path, a source of bone cement and an injection cannula. The cannula can be in communication
with the flow path such that inserting the cannula into a bone can allow a flow of bone cement
therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering
bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone
cement container, a low pressure drive mechanism configured to effect a flow of bone cement from
said container to the injector body and a high pressure drive mechanism configured to effect a flow
of bone cement through the injector body into the bone.
Appl: 20080260842
PERMEATION ENHANCING COMPOSITIONS FOR ANTICHOLINERGIC AGENTS
A transdermal or topical skin-friendly composition including anticholinergic agents, such as
oxybutynin, a urea-containing compound and a carrier system. A method is disclosed for treating a
subject for urinary incontinence while reducing the incidences of peak concentrations of drug and
undesirable side effects associated with oral anticholinergics.
Appl: 20080268035
Cationic Polymer Nanoparticles Encapsulating An Active Ingredients, And The Cosmetic Composition
Containing The Same
Disclosed herein are cationic polymer nanocapsules encapsulating an oil-soluble active ingredient,
and a cosmetic composition containing the same. The cationic polymer nanocapsules have a
molecular weight of 5,000-100,000, a surface potential of 5-100 mV and a particle size of 50-500
nm. Also, disclosed is a cosmetic composition containing said cationic polymer nanocapsules.
Appl: 20080275375
ADHESIVE COMPOSITION FOR A HUMID MEDIUM, BASED ON BLOCK COPOLYMERS
COMPRISING AT LEAST ONE HYDROPHILIC BLOCK
The invention relates to a block copolymer which is produced by a controlled radical
polymerization, has an individual composition and structure and is used for adhesion in a humid
medium The inventive copolymer comprises a continuous flexible and water repellent matrix (of
elastomer nature) and a dispersed phase in the form of hydrophilic nanodomains. Said copolymer
exhibits an excellent adhesion as a result of the structure thereof also in a very humid medium.
Appl: 20080279764
METHOD AND COMPOSITION FOR TREATING CANCER
A method for treating cancer, preventing cancer or delaying the progression of a cancer in an
animal or a human comprising the step of: administering to the animal or the human having a
cancer a composition in an amount effective to treat cancer, prevent cancer or delay the progression
of cancer in the animal or the human. The composition comprises a pharmaceutically acceptable
excipient, and ascorbate which is joined to a carrier structure containing an anti-cancer active agent,
said carrier structure being capable of releasing the anti-cancer agent in the presence of a reactive
oxygen species.
Appl: 20080279901
Composition comprising encapsulated silicone compounds
The present invention relates to a cosmetic composition intended for the care and/or make-up of
keratinous substance(s) comprising, in a physiologically acceptable medium, at least one compound
X, one compound Y and at least one catalyst, with at least one of the compounds X or Y being a
polyorganosiloxane, and said compounds X and Y being capable of reacting together by a
hydrosilylation reaction in the presence of a catalyst, with at least one compound from the
compounds X and Y being present in said composition in an encapsulated form, said catalyst being
combined with at least one of said encapsulated compound X or Y.
Appl: 20080292681
Use of Dha, Epa or Dha-Derived Epa for Treating a Pathology Associated with Cellular Oxidative
Damage
The present invention relates to the use of an acid enriched in docosahexaenoic acid (DHA) or
eicosapentaenoic acid (EPA) or DHA-derived EPA for manufacturing a drug for the treatment of
processes that involve associated oxidative damage. In particular, it is for the treatment of processes
associated with neurodegenerative, ocular, ischaemic and inflammatory pathology, atherosclerosis,
with oxidative damage to DNA and with physical exercise.
Appl: 20080292703
Antitumoral Bioconjugates of Hyaluronic Acid or Its Derivatives Obtained by Indirect Chemical
Conjugation, and Their Use in the Pharmaceutical Field
The present invention describes a new group of bioconjugates which can be obtained by means of
indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs
with an antitumoral activity belonging to different groups, their preparation process and use in the
oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have
different physico-chemical properties which improve their tolerability and efficiency and allow a
more accurate modulation of the dosage, exploiting an active targeting mechanism.
Appl: 20080305055
Anti-Radical Agents
Compounds of the formulae (1), (2) and selected hindered nitroxyl, hydroxylamine and
hydroxylamine salt compounds such as the compound of formula (3), wherein Gi is hydrogen;
C.sub.1-C.sub.22alkyl; C.sub.1-C.sub.22alkylthio; C.sub.2-C.sub.22alkylthioalkyl; C.sub.5C.sub.7cycloalkyl; phenyl; C.sub.7-C.sub.9phenylalkyl; or SO.sub.3M; G.sub.2 is C.sub.1C.sub.22alkyl; C.sub.5-C.sub.7cycloalkyl; phenyl; or C.sub.7-C.sub.9phenylalkyl; E is oxyl or
hydroxyl; V is --O--; or --NH--; a is 0 or 1 or 2; b, c and d and g are each independently of one
another 0 or 1; e is an integer from 1 to 4; f, m, n and p are each independently of one another an
integer from 1 to 3; q is 0 or an integer from 1 to 3; Q, T and G.sub.3 are as defined in claim 1;
G.sub.4 and G.sub.5 are each independently of the other hydrogen; or C.sub.1-C.sub.22alkyl;
exhibit marked antiinflammatory action.
Appl: 20080305152
Methods of Inducing Melanogenesis in a Subject
Described herein are methods and compositions for inducing melanogenesis in a human subject.
The method comprises administering to a subject an alpha-MSH analogue, in an effective amount
and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without
inducing homologous desensitization of the melanocortin-1 receptors.
Appl: 20080305193
Cosmetic compositions
A cosmetic composition suitable for topical application to human or animal skin comprising an
effective amount of active ingredient dispersed in an acceptable cosmetic base or carrier, wherein
the active ingredient comprises a mixture of an amino acid, a low glycemic glycoside and a
Vitamin, wherein the amino acid is L-arginine, and wherein the low glycemic glycoside is derived
from kiwi fruit.
Appl: 20080308744
Serum Albumin Conjugated to Fluorescent Substances for Imaging
Compositions and methods are disclosed for imaging tissue or a lymphatic or circulatory system,
for example, in the near infrared. Dyes that emit wavelengths in the infrared or near infrared
regions of the spectrum may be employed on their own, as combinations or complexed with serum
albumin, or as part of a covalent conjugate with serum albumin.
Appl: 20080311163
Cosmetic Treatment With Nitric Oxide, Device For Performing Said Treatment And Manufacturing
Method Therefor
A cosmetic treatment method, and a device therefor, are provided that allow for cosmetic treatment
of cosmetic disorders, caused by chronological age, environmental factors, changes in
physiological functions of skin, such as psoriasis, dermatitis, acne, cellulites, and viral and/or
bacteriological attacks. The device comprises a nitric oxide (NO) eluting polymer arranged to
contact the area to be cosmetically treated, such that a cosmetic dose of nitric oxide is eluted from
said nitric oxide eluting polymer to said area. The nitric oxide (NO) eluting polymer is integrated
with a carrier material, such that said carrier material, in use, regulates and controls the elution of
said cosmetic dosage of nitric oxide (NO). Furthermore, a manufacturing method for said device is
provided.
Appl: 20080317679
FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL
AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND
THEIR USES
The present invention relates to a foamable therapeutic composition comprising: (a) a
therapeutically effective concentration of at least one active agent selected from the group
consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable
carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of
water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an
emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group
consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent,
a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surfaceactive agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied
or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total
composition; wherein the composition is housed in a container and is substantially flowable, and
which upon release expands to form a breakable foam; and wherein the foamable carrier is selected
to generate a foam of good to excellent quality. The invention further provides a method of treating,
alleviating or preventing a disorder of mammalian subject, comprising administering such a
composition to an afflicted target site.
Appl: 20080317850
Buccal Delivery System
A buccal delivery system capable of being blended in a normal dry powder process and compressed
using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an
effective amount of one or more active ingredients; (b) an amount of one or more polyethylene
glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to
provide the required hardness and time for dissolution of the matrix; (c) 0.05-2% by weight of the
total matrix of one or more suspending agents; (d) 0.05-2% by weight of the total matrix of one or
more flowing agents; and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.
US PATENTS IN NANOTECHNOLOGY FOR SKIN CARE
GRANTED FROM 1980 TO 2008
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Spectroscopic analysis of chemical substances
An intense electric field is employed as the external source of energy in carrying to a spectroscopic
analysis of a chemical composition. The substance to be analyzed is placed between an insulated
conductive electrode and a ground reference. A high voltage is then applied to the electrode to
generate an electric field of a predetermined intensity within the test sample. As a result of the
energy absorbed, the constituents of the sample are caused to release their characteristic spectral
emissions. These emissions are optically filtered to isolate the wavelength of interest which is
passed to a light detector and registered on a photon counting system. The procedure is especially
and uniquely applicable for conducting an in situ chemical analysis of human sweat, thus offering a
valuable aid in the diagnosis of various medical abnormalities.
Processes of making a porous membrane material from polyvinylidene fluoride, and products
Covers processes for making microporous membranes and molecular filtration membranes from
vinylidene fluoride polymers, and the products so produced. A continuous version of the process
consists of applying a layer of a solution of a polyvinylidene fluoride polymer to a rigidly
supported surface of a backing belt to form a film, then passing the belt through a formation bath,
in which the membrane is formed. To form the polymer solution, the polymer is dissolved in a
liquid vehicle that will dissolve up to about 25% by weight of the polymer at a temperature of at
least 50.degree. C. but that dissolves substantially less of the polymer at about 20.degree. C. (room
temperature). The polymer solution is formed at 50.degree. C. or higher, and the formation bath is
maintained at about room temperature. The formation bath is a mixture of the liquid vehicle solvent
with a second liquid that is miscible with the solvent but that is not itself a solvent for the polymer.
The film is maintained immersed in the formation bath until it has been converted to a porous
membrane whose pore structure is essentially fully formed, by leaching of the solvent from the film
and its replacement with the non-solvent liquid. Thereafter the residual solvent is extracted from
the porous membrane, and after separation of the membrane from the backing belt, the membrane
is dried. The preferred solvent - non-solvent system for the formation bath is acetone-water. A
preferred formation bath composition is from about 70% to about 80% acetone by volume.
Method of producing an accellerating electrons and ions under application of voltage and arrangements
connected therewith
An electron and ion accelerator includes plural spaced electrodes which are apertured to define a
gas discharge path and supported at their peripheries by insulative means. A gas supply provides
low pressure gas capable of producing electrons and ions in the gas discharge path. A voltage
applied between the at least two electrodes establishes an electrical potential between them such
that a spark-like gas discharge occurs along the gas discharge path. The current density obtainable
in the low pressure gas is substantially higher than the density of an electron or ion flow in a
vacuum.
Method and apparatus for measuring moisture content of skin
There are disclosed a method and an apparatus for measuring moisture content of skin. The skin
surface is illuminated with polarized light incident at the Brewster angle. The degree of polarization
of the light refracted within the skin and reflected out is measured. The measurement is a function
of the refractive index of the skin which, in turn, is a function of the moisture content. To avoid
measurement variations due to such things as skin color, output readings are in the form of a ratio
of the reflected polarized light intensity to the reflected total light intensity.
Sunscreen method
Sunscreen compositions are described which comprise a pharmaceutically acceptable carrier having
incorporated therein, in an amount effective to provide protection against the harmful effects of
ultraviolet radiation, a compound of the formula ##STR1## wherein X is an alkylene group
containing 1 to 7 carbon atoms and the amino group of unspecified position is substituted meta or
para to the ester group.
Benzylidene-camphors, processes for their preparation and cosmetic compositions containing them
The invention provides compounds which are particularly valuable for use as the active ingredient
in sun tan lotions and creams and the like. These compounds have the general formula: ##STR1##
in which Y denotes hydrogen or the radical SO.sub.3 H or a salt thereof with an organic or
inorganic base, and Z denotes the radical --CH.sub.2 Br or --CHBrBr or a radical Z' which denotes
the radical --CH.sub.2 I, --CH.sub.2 R, --CHR'R', --CHO or --COOR", in which R denotes -NR.sub.1 R.sub.2, --N.sup.+ R.sub.1 R.sub.2 R.sub.3, --OR.sub.4, --OCOR.sub.5, --SR.sub.6, -CN, -COOR" or --SSO.sub.3 Na, in which R.sub.1 and R.sub.2 independently denote hydrogen,
C.sub.1-18 alkyl or hydroxyalkyl, or R.sub.1 and R.sub.2, together with the nitrogen atom to which
they are attached, denote a heterocyclic ring, R.sub.3 denotes C.sub.1-4 alkyl or hydroxyalkyl or
sulphonatopropyl, R.sub.4 denotes hydrogen, alkyl, polyoxyethylene, aryl which is optionally
substituted, menthyl or dialkylaminoalkyl, R.sub.5 denotes alkyl, alkenyl, aryl or a 5 or 6
membered heterocyclic ring which is optionally aromatic, and R.sub.6 denotes hydrogen, alkyl,
carboxyalkyl, aminoalkyl, hydroxyalkyl, aryl or 3-alanyl, R' denotes --OR'.sub.4 or --SR'.sub.6, in
which R'.sub.4 and R'.sub.6 are as defined under R.sub.4 and R.sub.6, respectively, except for
hydrogen, polyoxyethylene, hydroxyalkyl, 3-alanyl and aryl, and R" denotes hydrogen or alkyl,
such that when R denotes N.sup.+ R.sub.1 R.sub.2 R.sub.3, R.sub.1 and R.sub.2 are not hydrogen
and either R.sub.3 denotes sulphonatopropyl, or the compound is in the form of a salt with an
anion, which is SO.sub.4 alkyl, SO.sub.3 aryl, SO.sub.3 alkyl or halogen or an inorganic or organic
acid addition salt thereof when R denotes --NR.sub.1 R.sub.2.
Apparatus for obtaining an objective determination of the rate of oxygen utilization in peripheral tissue
Apparatus employing a non-invasive method for objectively determining in vivo, the rate of oxygen
utilization in peripheral tissue by spectral measuring means, containing a light source, a clamp or
tourniquet for occluding a segment of blood in the tissue, means for transmitting the light through
the isolated segment of blood to pick up the spectral values of the oxyhemoglobin for two selected
wavelengths, wherein the rate of reduction of the oxyhemoglobin of the blood as determined at one
wavelength is faster that the rate of reduction of the oxyhemoglobin at the other wavelength, means
for converting the spectral values individually for the two selected wavelengths into current flow,
and means for determining the time-space relationship between the changing spectral values of the
two selected wavelengths, from the moment of occlusion.
Liquid, cinnamal dialkyl malonates as sole organic sunscreens
Non-polar cosmetic oil compositions containing a liquid cinnamal dialkyl malonate are very
effective in providing broad spectrum sunscreen protection.
Method and means for repelling animals
Described for use as a key ingredient in an animal control composition and more particularly in an
animal repellent composition, is the genus of steroids defined according to the structure: ##STR1##
wherein X completes a substituted cyclopentyl moiety and is one of the moieties: ##STR2##
wherein Y represents methylene, carbinol or keto; and wherein Z completes a substituted
cyclohexyl moiety and is one of the moieties: hydroxycyclohexyl; ketocyclohexyl;
ketocyclohexenyl; hydroxyphenyl; cyclohexenyl; or bicyclohexyl and wherein the dashed line
represents a carbon-carbon single bond or a carbon-carbon double bond. Also described are animal
control articles consisting of one or more members of the above mentioned steroid genus and
imbedded in a compatible polymer.
Transcutaneous application of nicotine
Percutaneous administration of nicotine in a dose approximating the dose delivered by a variety of
nicotine-containing products, such as cigarettes, cigars, snuff and chewing tobacco, is carried out
using an occlusive pad. The nicotine is delivered so as to mimic the pharmacological effects of
nicotine provided by the conventional use of tobacco, and a therapeutic function is achieved by
reducing or eliminating the need for the tobacco product. A suitable transdermal application pad
comprises a reservoir for liquid nicotine base to be affixed to the skin in a variety of places. Due to
the high lipid solubility and resultant high skin permeability of nicotine, vehicles or solvents are not
generally needed to enhance dermal absorption.
Substituted cinnamal dialkyl malonates in sunscreening, skin care compositions
Compositions containing an organic sunscreen and particular substituted cinnamal dialkyl malonate
adjuvants therefor are very effective in providing broad spectrum sunscreen protection and skin
care.
Device and method for determining skin type
A battery-powered device and method for determining the skin type of a living subject is disclosed
in which an oil sample carried by a probe is subjected to the impingement of an essentially
monochromatic light source of predetermined wavelength. The amount of light passing through the
oil sample is detected and an output voltage proportional thereto is produced. This output voltage is
amplified, integrated and then drives an LED display which indicates the skin type of the subject.
Calibration means and a method for calibrating the device utilizing both an oil-free and oily probe
are disclosed. The calibration means include both means for adjusting the bandwidth of the output
of the amplifying circuit and gain control means for adjusting the output voltage of the amplifying
circuit.
Percutaneous access device and method for implanting same
A percutaneous access device (PAD) is provided with a sleeve or separable member which may be
detached from the device to enable the culturing of a multilayer fibroblast coating on the member in
a stable and undisturbed environment. The member is constructed so that when it is assembled into
the device and the device is implanted in a patient, the cultured coating of the member is exposed to
the patient's dermis whose fibroblasts will, after a relatively short healing period, merge with the
fibroblasts of the coating to form a barrier layer interlocked with the member to prevent epidermal
ingrowth or marsupialization of the implanted device. Implantation techniques for further
facilitating the formation of the dermal barrier are also disclosed.
Device and method for determining skin type
A battery-operated device and method for determining the skin type of a living subject is disclosed
in which an oil sample carried by a probe is subjected to the impingement of an essentially
monochromatic light source of predetermined wavelength. The amount of light passing through the
oil sample is detected and an output current proportional thereto is produced. This output current is
amplified and drives a meter which displays the skin type of the subject. Calibration means and a
method for calibrating the meter utilizing an oil-free probe are disclosed, as well as a means for
adjusting the bandwidth of the output of the amplifier to coincide with the meter.
Curved structure and method for making same
A plurality of thin flexible sheet ribs are secured to thin flexible sheet stringer members to form a
distortable frame structure. One edge of the ribs lie in a curved surface such as a parabolic
cylindrical surface. A thin sheet of boron-silicate glass, preferably formed with a second surface
mirror, is annealed and then bent at room temperature to abut the edges of the ribs lying in the
curved surface and is retained in place by ribs at opposite edges of the sheet. The inherent strength
of the glass under stress, when bent, provides structural rigidity to the combined elements.
Method of relieving pain and inflammatory conditions employing substituted salicylamides
A topically and systemically administered anti-inflammatory composition for human and for
veterinary consumption which comprises compounds of the general formula: ##STR1## wherein
R.sub.1, R.sub.2 and R.sub.3 are defined hydrocarbon attachments and Y is --OH or a phenolic
ester group derived from the reaction of such --OH group with a carboxylic acid halide or anhyride.
In typical compounds covered by said general formula (a) R.sub.1 is H, R.sub.2 is 5,n-octanoyl, Y
is hydroxy and R.sub.3 is p-trifluoromethylphenyl; (b) R.sub.1 is H, R.sub.2 is 5,n-decanoyl, Y is
hydroxy and R.sub.3 is benzothiazol-2-yl and (c) R.sub.1 is H, R.sub.2 is 5,n-decanoyl, Y is
acryloyloxy and R.sub.3 is p-nitrophenyl. The resulting compositions take the form of ointments,
solid sticks, tablets, capsules, injectable solutions and suspensions, ear drops, eye drops, nose
drops, douches, suppositories, enemas, liniments, gels, lotions, shampoos, soaps, creams, solutions,
aerosols, pads, plasters, bandages, dressings and catamenial and non-cateminal tampons. The
compositions are useful in relieving pain or inflammation as well as microbial infections in
mammals when applied topically to the skin or affected organs or when administered systemically.
Dispersing casting of integral skinned highly asymmetric polymer membranes
There is disclosed, in one aspect, an improved highly asymmetric membrane comprising a skin and
a porous asymmetric support. The skin contains pores which have an mean pore diameter of from
about 0.005 to about 3.0 microns and the asymmetric support comprises a reticulated structure
which contains pores which have pore diameters of from about 10 to about 20,000 times as large as
the pore diameter of the pores of the skin. The membrane has a bulk porosity greater than about
70%. In another aspect, there is disclosed a process for preparing these membranes. This process
comprises casting a polymer dope while the dope is in an unstable liquid dispersion condition. The
concentration of polymer in the polymer dope should be high enough to produce a coherent
membrane yet low enough to form a substantially all-reticulated structure within the asymmetric
support. The membranes are characterized by high flow rates, excellent retention properties, and
improved resistance to fouling.
Wrinkle treatment formulation
A wrinkle treatment formulation is provided which is in the form of a gel formed of at least 95% by
weight of a gelable hydrophilic polyurethane polymer base and a precipitated silica thickener
gelling agent. Upon brushing the above-described gel formulation on wrinkled skin, the gel fills up
wrinkles and dries to impart to so-treated skin a smooth substantially wrinkle-free appearance.
Disposable cell culture chamber with remote access
A combination is provided of a percutaneous lead designed for implantation in the human body,
which lead has a surface which is adapted to pass through and be exposed to the dermis of a patient
when the device is implanted. Said surface is adapted to receive the growth of a cultured
autogenous fibroblast coating on an etched, nanoporous surface. A liquid tight sealed removable,
disposable chamber encloses said surface, said chamber being provided with openings for
introduction therein of finely divided living dermal tissue suspended in a liquid carrier, thus
providing a means for formation of the cultured surfaces which can be easily handled. The
disposable chamber is removed and discarded at the time of surgery.
Skin protective composition
A skin protective composition for topical application to mammalian skin for protection from
infrared radiation containing titanium dioxide and mica or coated mica as its principal active
reagents.
Infrared blocker
A transparent or translucent composition for topical application to mammalian skin for protection
from infrared rays comprising fumed silica admixed with conventional UV blockers as its principal
active constituents.
Combined sensor for the transcutaneous measurement of oxygen and carbon dioxide in the blood
The combined sensor with a thermostatted heating device (7, 23) for the simultaneous and
continuous transcutaneous measurement of oxygen (O.sub.2) and of carbon dioxide (CO.sub.2) in
the blood contains a measuring device (1) for the partial pressure of CO.sub.2 (pCO.sub.2), in
which there is pure optical/spectrometric operation or which operates on the principle of pH
measurement in an electrolyte (8), and which is separated from the measuring site on the skin by a
membrane (13) which is permeable to both CO.sub.2 and light, and contains another measuring
device (24, 25, 26) for the spectrometric measurement of the blood oxygen saturation (sO.sub.2).
The advantage over a known pO.sub.2 /pCO.sub.2 combined sensor is that the combined sensor
according to the invention can be operated at a low operating temperature of, for example,
42.degree. C. or less, so that continuous measurement for 24 hours, for example, is possible without
resiting or recalibrating the sensor, and thus it is simple to use in the domestic milieu.
Method for healing damaged skin
A composition and method of using the same for treating human skin of all races for a wide variety
of skin ailments, including acne, blemishing, aging, sun damage and cancerous lesions, and other
problems associated with skin disorders. The method comprises applying to a region of damaged
skin a composition of trichloroacetic acid, a surfactant having cell growth stimulatory properties,
and an emulsifier. The ratio of the various ingredients can be varied to effect optimal treatment for
a particular type of skin. For treatment of certain disorders, the effect of the composition is
enhanced if the skin is irradiated with a suitable light source. The latter stimulates even skin
regeneration. Several days after treatment, the damaged area peels off, and a new layer of vibrant,
evenly colored, healthy skin is apparent. The procedure can be repeated without adverse effects,
although generally a single application is sufficient.
Method for eradicating infectious biological contaminants in body tissues
A method for externally eradicating infectious pathogenic contaminants, such as enveloped viruses,
bacteria, trypanosomal and malarial parasites, present in body tissues, such as blood, blood
components, semen, skin, and cornea, before the treated body tisues are introduced into, or
transplanted onto, the body of a human or an animal. Such method includes the steps of: (1)
admixing an effective, non-toxic amount of photoactive compound, whch has a selectivity for
binding to the infectious pathogenic biological contaminants present therein, with the body tissues
outside the body to produce a resulting body tissues; (2) passing the resulting body tissues through
an irradiating cell assembly, and (3) irradiating the resulting body tissues in the irradiating path of
the cell assembly for an effective period of time with an effective level of radiation such that the
radiation penetrates the resulting body tissues and eradicates the photoactive-compound-bound
contaminants present in the resulting body tissues and produces a decontaminated body tissue
suitable for introducing into, or transplanting onto, the body of a human or animal.
Waterproof sunscreen
A skin protective composition for topical application to mammalian skin for protection from water
washing containing C.sub.18 -C.sub.36 aliphatic wax and anhydrous starch as its principal active
waterproofing agents disposed in a water-free carrier.
Bump-forming media including thin intermediate reflective layer and methods for writing, reading, and
erasing same
An optical data storage medium includes a triple layer recording structure having an expansion
layer, a retention layer and a very thin reflective layer interposed between the retention and
expansion layers. The three layers are strongly bonded together so that the thermally and
mechanically active expansion and retention layers can mechanically act upon each other through
the intermediate reflective layer. The expansion and retention layers are dyed to selectively pass or
absorb light of preselected wavelengths. The thin reflective layer is adapted to partially pass and
partially reflect light of preselected wavelengths.
Compositions and methods for reducing the risk of sunlight and ultraviolet induced skin cancer
Compositions and methods for reducing the risk of skin cancer. The novel compositions include at
least one effective protease inhibitor. Preferred protease inhibitors include serine protease inhibitors
and metallo- protease inhibitors. The protease inhibitors are preferably included in concentrations
ranging from approximately 10 picograms to 10 milligrams per milliliter of the skin-applicable
topical mixtures. The topical mixtures preferably include a suitable topical vehicle such as a cream,
lotion, or ointment. One class of anti-carcinogenic skin treatment compositions of this invention
preferably includes the desired protease inhibitors in combination with a suitable sunscreen agent
or agents, such as para-amino benzoic acid, to provide particularly advantageous compositions for
reducing the risk of sunlight-induced skin cancer.
Method and apparatus for aiding in the reduction of incidence of tobacco smoking
A method of aiding in the reduction of incidence of tobacco smoking. The method comprises
applying a patch containing nicotine to the skin of a person with whom smoking reduction is
desired and allowing the nicotine to transdermally migrate into the person's bloodstream to achieve
a desired systemic nicotine level. The method also comprises the simultaneous administration of a
nicotine containing aerosol spray to the oral cavity of the user in order to provide the desired
sensations in the respiratory tract to which the user is accustomed from normal tobacco smoke. A
combination of the spray and transdermal patch is also provided such that an occlusive patch is
applied to the skin of the person with whom smoking reduction is desired and the nicotine
containing aerosol spray is delivered to the oral cavity simultaneously with the application of the
nicotine from the patch.
Methods of treating tumors with compositions of catecholic butanes
The invention relates to methods useful in the treatment of benign, premalignant and malignant
solid tumors, especially those of the skin comprising methods for the administration of
pharmacologically active compositions containing catecholic butanes. The invention also relates to
methods of preventing the occurence of tumors, and the use of catecholic butanes as a sunscreening
agent. The preferred catecholic butane is nordihydroguaiaretic acid. The preferred methods of
application of the compositions containing catecholic butanes are by topical application and
intratumor injection.
Personal UV radiometer
A miniaturized portable battery operated combined power/energy radiometer appropriate for
personal use provides a convenient means for determination of the direction of maximum radiant
UV power and the measurement of the total energy over time or dosage. The radiometer possesses
particular usefulness for sunbathers, walkers, and other persons who are exposed to ambient
radiation. Suitably the radiometer includes means for attachment to an article of clothing and/or a
positionable stand.
Dual action sunscreen composition
Dual action sunscreen compositions capable of both moisturizing the skin and protecting it from
sunburn are made from a cationic guar, a cationic acrylic polymer and an ultraviolet absorbing
sunscreening agent.
Method and apparatus for measuring thickness of fat using infrared light
A body fat thickness measuring device comprising a pair of infrared emitting diodes, one emitting a
steady, low-intensity light, and the other emitting periodic, high-intensity pulses of light, to be
placed against the skin where the fat is to be measured. The device contains an array of detectors in
the form of infrared-sensitive photo-transistors which are placed against the skin in predetermined
locations near the two diodes, yet shielded from ambient light. The detector array provides signals
proportional to the amount of infrared light detected, and these signals are summed and amplified,
forming a composite signal. The amplitude of this composite signal, which is indicative of the
thickness of the layer of fat, is displayed on a digital readout device.
Method and apparatus for aiding in the reduction of incidence of tobacco smoking
A dermally applicable patch adapted for application to the skin of the user to enable a transdermal
administration to the bloodstream of a user. The patch comprises an outer layer which is
impermeable to the passage of nicotine and an inner layer which may operate as a rate controlling
membrane to allow the passage of nicotine into the bloodstream of a user. An outer layer and an
inner layer form a nicotine receiving area for receiving the nicotine to thereby allow the same to
pass through the inner layer. In a preferred embodiment, the patch is highly effective in reducing
the incidence of tobacco smoking by allowing transdermal nicotine migration into the bloodstream
of a user at a rate sufficient to correspond to the nicotine level in the blood achieved by smoking.
Photoprobe assembly
A relatively compact easily portable photoprobe assembly is disclosed which includes an electric
probe for locating acupuncture points and a light emitting diode to stimulate acupuncture points as
well as injury sites. The probe and light emitting diode are controlled by an internal circuit which
operates to provide a visual indication of the precise location of the desired treatment area via an
impedance variation procedure as well as to pulse the light emitting diode at the desired frequency.
A power supply is also contained within the assembly to render it completely portable.
A method of depilation using a ruby red laser includes supplying optimum energy to a selected area
of skin to cause follicular injury to the extent that depilation occurs without epidermal scaring.
Master hologram and micropattern replication method
A hologram is directly recorded in a sensitized metal substrate. The hologram may be an amplitude
hologram, or may be treated to produce a phase relief hologram which may be stamped into a
plastic material for reproduction, be archivally stored, or used as a master for electroforming a
second durable surface relief hologram for use as an embossing master. A suitable material is
prepared from a polished silver plate exposed to halogen vapors. After exposure, the plate is
developed and fixed, and the surface is differentially etched to form a surface relief suitable for
hologram embossing. Daguerreotype processes are modified to make surface amplitude holograms
and phase holograms. By etching through a metal film a semiconductor mask is obtained. By
depositing a silver film directly on a wafer, masks are made with very high feature definition.
Surface treatments to impart hydrophilicity
Water insoluble polymers are treated to place on their exposed surfaces the pendant alkyl
imidocarbonyl (amide) groups to impart a high degree of hydrophilicity to that surface. Nitrilecontaining polymers or copolymers in the form of insoluble films, filters or membranes are treated
to convert a substantial fraction of the surface nitrile groups into the corresponding amide by the
use of hydrogen peroxide or concentrated acids. The surface is rendered hydrophilic and resistant to
fouling to the extent that even proteins are not denatured thereupon. The surface may also be
converted to substituted amides by subsequent reactions to impart to it other functionalities or to
serve as the basis for coupling reactions. Other polymers capable of surface treatment to produce
pendant amidocarbonyl groups include ones containing pendant esters which on cleavage of the
oxygen-carbon bond give pendant alcohol groups. These are converted by cyanoethylation to form
the pendant nitrile groups which can be converted to the amide. Other polymers which on
hydrolysis give pendant carboxylic acids can be treated with ammonia to also produce pendant
amide groups.
Instrument for non-invasive measurement of blood glucose
Near-infrared quantitative analysis instruments non-invasively measure blood glucose by analyzing
near-infrared energy following interactance with venous or arterial blood, or transmission through a
blood containing body part. A replaceable cartridge stores data unique to an individual patient/user.
The analysis instruments are accurate and readily lend themselves to at-home testing by diabetics.
Nondestructive measurement of soluble solids in fruits having a rind or skin
The instant invention is drawn to efficient and nondestructive measurement of soluble solids in
fruits having a rind or skin, utilizing: infrared radiation source means for providing a beam or near
infrared radiation of sufficient intensity to penetrate the fruit, intensity measurement means for
measuring the intensity of radiation exiting the fruit, correlating means for correlating the
measurements of intensities of the exiting radiation: wherein the near infrared radiation source
means and the intensity measurement means are positioned such that when a fruit is positioned
within the device, the distance measured along the rind or skin of the fruit between (1) where the
center of the beam intersects the rind/skin, and (2) a point on the rind/skin where the center of the
field of detection intersects the rind/skin is at least about 8 cm.
Water resistant sunscreen compositions and methods of using same
A skin protective sunscreen composition exhibiting enhanced water repellency and conditioning
effects comprising ultraviolet blockers, aliphatic waxes and hydrophobic silicones disposed in a
pharmacologically acceptable water-free carrier. The composition when used in accordance
herewith is useful to protect mammals from solar radiation.
Shaving system
A shaving unit that comprises at least one blade and a shaving composite has a surface for engaging
the user's skin adjacent the blade edge. The shaving unit may be of a disposable cartridge type
adapted for coupling to and uncoupling from a razor handle or may be integral with a handle so that
the complete razor is discarded as a unit when the blade or blades become dulled. The blade edge
(or edges) cooperate with skin engaging surfaces to define shaving geometry. The skin-engaging
surface includes a shaving aid composite that is a mixture of water insoluble matrix material, an
effective amount of shaving aid material, and an effective amount of water-insoluble essential oil
material, the water-insoluble essential oil material being delivered from the shaving aid composite
concurrently with the delivery of the water-leachable shaving aid material during shaving to apply
at least about one nanogram of the essential oil to the skin surface per square centimeter of skin
surface.
Method and device for monitoring UV radiation
A device for monitoring UV radiation received by the skin comprises a housing. Adhesive on a
face of the housing secures the device to the skin. A patch of irreversible UV sensitive material
which changes color on being subjected to UV radiation is applied to an inner surface of the
housing and receives UV radiation reflected from the skin. The color of the UV sensitive patch is
compared with reference colors on the housing for determining the quantity of UV radiation to
which the skin has been subjected.
Polymer mixtures useful in skin care
Binary polymer mixtures of albumin and glycosaminoglycan and ternary polymer mixtures of
polyionic polypeptide and high molecular weight and highly charged polyanions are useful for
managing skin including wrinkles or other irregularities. Aqueous compositions of the ternary
mixtures have pH dependent phase change properties and provide skin activated films.
Pharmaceutical and cosmetic depigmentation compositions with a caffeic acid base
A pharmaceutical or cosmetic depigmenting composition for application to the skin so as to
improve the aesthetic appearance of the skin or to treat pathological or accidental
hyperpigmentation contains caffeic acid or an ester or amide thereof in an amount effective to
depigment the skin.
Product based on inorganic or organic lamellar particles, containing a melanotic pigment, process for
preparing it and its use in cosmetics
The invention relates to a product in powder form consisting of organic or inorganic particles
having a lamellar structure, having a size of less than 50 microns and containing at least one
synthetic melanotic pigment formed in situ by oxidation of an indole compound, and to its use for
the protection of the human epidermis, in make-up products and for dyeing hair.
Laser treatment method for removing pigmentations, lesions, and abnormalities from the skin of a living
human
A laser treatment method is provided which removes pigmentations, lesions, and abnormalities
from the skin of a living human. The methodology comprises a carefully controlled irradiation of
the chosen treatment site on the skin of a living human; avoids the creation of cosmetically
disfiguring scars; and eliminates the typical hypopigmentation as well as the pitting and other
changes in skin texture normally accompanying conventionally known laser treatment techniques.
Non-invasive blood analysis by near infrared absorption measurements using two closely spaced
wavelengths
Systems and methods for non-invasive blood analysis are disclosed in which blood is illuminated at
a plurality of discrete wavelengths selected from the near infrared spectrum. Measurements of the
intensity of transmitted or reflected light at such wavelengths are taken, and an analysis of
transmittance or reflectance ratios for various wavelengths is performed. Changes in the ratios can
be correlated with specific near infrared (IR) absorption peak for the analyte which varies with
concentration of the analyte (the data wavelength) and the a second (reference) wavelength being
sufficiently removed from the first so that measurements of light absorption at this second
wavelength are relatively insensitive to the concentration of the analyte and yet the second
wavelength is sufficiently close to the first wavelength to minimize interference from scattering
effects and the like. Typically, the window bracketing these closely spaced wavelengths will be less
than about 300 nm and preferably less than about 60 nm wide and, in some instances, more
preferably less than about 30 nm wide.
Infrared glucose sensor
Systems and methods for non-invasive blood analysis for the presence of glucose are disclosed in
which blood is illuminated at a plurality of discrete wavelengths selected from the near infrared
spectrum. Measurements of the intensity of transmitted or reflected light at such wavelengths are
taken, and an analysis of transmittance or reflectance ratios for various wavelengths is performed.
Changes in the ratios can be correlated with specific near infrared (IR) absorption peak for glucose
at about 1600 nm 15 nm which varies with concentration of the analyte (the data wavelength) and
the a second (reference) wavelength being sufficiently removed from the first so that measurements
of light absorption at this second wavelength are relatively insensitive to the concentration of the
analyte and yet the second wavelength is sufficiently close to the first wavelength to minimize
interference from scattering effects and the like. Typically, the window bracketing these closely
spaced wavelengths will be less than about 300 nm and preferably less than about 60 nm wide and,
in some instances, more preferably less than about 30 nm wide.
Fluorescent suntanning lamps
A skin tanning fluorescent lamp having a coating of a uniform and homogeneous deflocculated
physical mixture of a first and second phosphor where the first phosphor has a desired emission in
the spectral region from about 320 to about 400 nanometers and the second phosphor has a desired
emission in the spectral region from about 280 to about 320 nanometers, said first phosphor has a
first isoelectric point at a first pH and the second phosphor has a second isoelectric point at a
second pH. The first and said second pH form a range. The deflocculated coating is stabilized by
deflocculating the first and second phosphors at a third pH sufficiently outside of range to produce
a resulting coating consistently having desirable emission during production.
Non-invasive method for detecting deep venous thrombosis in the human body
A non-invasive method for detecting deep venous thrombosis in a human body wherein changes are
effected in the amount of deoxyhemoglobin in the body limb by trapping blood in the venous
system for a determinate time period and then releasing the trapped blood in the venous system.
During the period that the changes in the amount of deoxyhemoglobin are effected, first and second
light sources emit light of two selected wavelengths which penetrate into the deep venous system of
the body limb so that the reflectance contributions can be used to measure changes in the flow and
amount of deoxyhemoglobin and to thereby detect the presence or absence of deep venous
thrombosis.
Method of inducing tanning by pulsed light and apparatus to effect same
A method and apparatus to effect tanning in humans. The method utilizes very short discrete
pulses, with a dark period of low to zero energization between discrete pulses, of ultraviolet or
visible light irradiation of selected wave length to effect the tanning. Different apparati are
disclosed to carry out the invention. One type of apparatus continuously generates irradiation of the
selected wave length and projects that irradiation through mechanical pathblockers to create the
discrete pulses. Another type of apparatus intermittently generates irradiation in the desired discrete
pulse and of the desired wave length to create the desired effect.
Method of binding a product to the membrane of a keratinocyte by means of a ligand-receptor bond,
method of preparing such a product, product obtained, cosmetic or pharmaceutical composition in which
it is present and its method of preparation
The invention relates to products which are to be bound specifically to the membrane of a
keratinocyte by means of a ligand-receptor bond. These products carry at least one ligand
consisting of an oside residue selected from .alpha.-L-rhamnose, .alpha.-D-galactose and .alpha.-Dgalactose-6-phosphate. By virtue of this specificity, it is possible to prepare cosmetic or
pharmaceutical compositions having an improved efficacy in particular, for example for
regeneration of the epidermis, for the treatment of psoriasis or for renewed hair growth.
Laser treatment method for removing pigement containing lesions from the skin of a living human
A laser treatment method is provided which removes pigment containing lesions, both normal and
abnormal medically, from the skin of a living human. The methodology comprises a carefully
controlled irradiation of the chosen treatment site on the skin of a living human; avoids the creation
of cosmetically disfiguring scars; and eliminates the typical hypopigmentation as well as the pitting
and other changes in skin texture normally accompanying conventionally known laser treatment
techniques.
Silicone emulsion for personal care application
A silicone oil-in-water emulsion composition and a method of topically treating human skin with
the composition. The emulsion constitutes water, a silicone oil, and at least two nonionic
emulsifiers. Each nonionic emulsifier is a solid at room temperature. One nonionic emulsifier has
an HLB value less than 8.0, while the other nonionic emulsifiers has an HLB value greater than
15.0.
Method of laser-induced tissue necrosis in carotenoid-containing skin structures
A method for treating dermatological organ disorders and skin lesions in a mammal through the use
of directed, pulsed laser light is described. The dermatological disorders are characterized by an
increase in concentration of potential photodynamic chemical compounds like carotenoid
compounds, and especially the carotenoid beta-carotene, compared to normal skin. Pulsed dye laser
light of a time and duration specific for maximal absorption by a carotenoid compound like betacarotene is directed at the regions of carotenoid accumulation within a skin disorder. Thermal
coagulation necrosis of the carotenoid-accumulating skin region results, though thermal damage to
surrounding tissue is limited in amount.
Method of targeting melanocytes with a compound containing a fucose residue
The invention concerns a method of binding a product to the membrane of a melanocyte by means
of a ligand-receptor bond, which comprises using a product consisting of a basic structure coupled
to at least one ligand consisting of an oside residue accessible to the membrane receptors, said
oside residue being a fucose residue, notably an Alpha-L-fucose residue.
Surface modification by accelerated plasma or ions
The present invention is a surface modification process which provides a means of rapidly heating
a thin layer of a polymer surface or a thin coating of material on a coated substrate and various
surfaces produced by such a process.
Topical ultra-violet radiation protectants
Disclosed are compositions for application to a surface to protect the surface from ultra-violet
radiation, which include zinc oxide particles having a substantially rod shape.
Process for lightening the skin or treating pigmental blemishes using a composition containing
benzomorpholine or 3,4-dihydro-2H-1,4-benzoxazine derivatives
A topical process for lightening the skin or treating pigmental blemishes consisting in applying to
the part of the skin to be treated a composition containing, as active compounds
hydroxybenzomorpholines and derivatives thereof corresponding to the following formula:
##STR1## in which: R.sub.1 represents a hydrogen atom or an alkyl radical having from 1 to 4
carbon atoms, and R.sub.2 represents a hydroxyl radical in the 6- or 7-position.
Product based on colored inorganic particles including a melanin pigment, process for its preparation
and its use in cosmetics
A product in the form of colored inorganic particles including one or a number of melanin
pigments, a process for its preparation and to its use, especially in the field of cosmetics, for makeup for the exoskeleton and/or for the skin, and in protecting human skin against UV radiation.
Utilization of derivatives of 2,5-dihydroxyphenyl-carboxylic acids, their homologs, and their salts in
preparation of a cosmetic or dermatological composition with a depigmenting action
A cosmetic or dermatological composition with a depigmenting action comprises derivatives of
2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having
the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, or ##STR2##
R.sub.5 is a hydrogen atom, a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or
branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one
or more hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a
C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6
polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle; the
number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;
R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1
-C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear
or branched C.sub.1 -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when
R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.
Fine dispersion of melanin pigments, its preparation and its use in cosmetics
The invention relates to a dispersion of melanic pigments containing in a medium selected
amongst: a) the straight or branched monoalcohols comprising at least 3 carbon atoms; the straight
or branched polyols comprising at least 2 carbon atoms; the saturated or unsaturated cycloaliphatic
alcohols comprising at least 6 carbon atoms; the aromatic alcohols comprising at least 6 carbon
atoms; the C.sub.8 -C.sub.22 fatty acid esters and C.sub.1 -C.sub.6 alcohol esters or the C.sub.2 C.sub.6 polyol esters; the C.sub.1 -C.sub.6 aliphatic acid esters or the C.sub.8 -C.sub.22 aromatic
acid and fatty alcohol esters; the C.sub.8 -C.sub.22 fatty acid esters and the C.sub.8 -C.sub.22 fatty
alcohol esters, the C.sub.6 -C.sub.22 polyacid and alcohol esters, the hydroxylated fatty acid
diesters; the straight or branched paraffins comprising at least 8 carbon atoms; the silicone oils; and
the mixture of these different organic compounds, or b) an emulsion comprised of a liquid defined
under a), non water miscible, water and an emulsifying agent, a melanic pigment in the form of
particles in which at least 75% of the particles have a grain size smaller than 10 microns. The
invention also relates to a method for the preparation and the utilization of such dispersion in
cosmetics.
Topical process for lightening the skin or treating pigmental blemishes using a composition containing 4thioresorcin derivatives
A topical process for lightening the skin or treating pigmental blemishes consisting in applying to
the part of the skin to be treated a composition containing, as active compounds, 4-thioresorcin
derivatives corresponding to the following formula: ##STR1## wherein: R represents a C.sub.1 C.sub.6 alkyl radical, a C.sub.1 -C.sub.6 haloalkyl radical, an aryl radical, an aralkyl radical which
is unsubstituted or substituted by a lower alkyl or lower alkoxy radical or a halogen atom, the
radical --C.sub.n H.sub.2n --COOR' where n is an integer between 1 and 5 and R' represents a
C.sub.1 -C.sub.6 alkyl radical, a morpholinoalkyl or piperidinoalkyl radical in which the alkyl
radical is C.sub.1 -C.sub.6, or the radical ##STR2##
Sunscreen agents
A sunscreen composition for application to human skin comprises an ultraviolet absorber which is
introduced as an anion into a layered double hydroxide of the general formula where M is a
divalent metal or lithium, N is a trivalent metal and X denotes anions present as an interlayer
between layers of metal atoms joined through the OH groups. Such layered double hydroxides are,
for this invention, suspended in a cosmetically acceptable vehicle.
Photoprotective/cosmetic compositions comprising 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5triazine and dioctyl malate
Topically applicable sunscreen/cosmetic compositions having improved cosmetic properties and
well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of
UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective
amount of 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) the oil dioctyl
malate, in an amount effective to itself substantially dissolve the total amount of triazine compound
(i), in a cosmetically acceptable vehicle, diluent or carrier therefor.
Photostable cosmetic screening composition containing a UV-A screening agent and a (4methoxybenzylidene)cyanoacetate
A photostable cosmetic composition for protecting the human epidermis against UV radiation
comprises, in a cosmetically acceptable carrier, from 0.5 to 5% by weight of 4-(1,1-dimethylethyl)4'-methoxydibenzoylmethane and at least 0.5% by weight of a compound of formula (I):
##STR1## where R stands for an alkyl radical, the molar ratio of the compound of formula (I) to 4(1,1-dimethylethyl)-4'-methoxydibenzoylmethane being 0.8 or over.
Skin preparation using nanospheres
Preparation for skin use comprising excipients, a drug carrier encapsulating beta-carotene and a
blend of UV-A and UV-B sun filters characterized in that: the drug carrier consisting of
nanospheres represents 3 to 6% by weight of the preparation; the proportion of UV-B filters is
greater than that of the UV-A filters; and the UV-B filters have a cinnamic structure. Application in
the treatment of melanic skin stains.
Examination of breast tissue using time-resolved spectroscopy
A method of breast tissue examination using time-resolved spectroscopy includes the following
steps. A support that includes an input port and an output port separated by a selected distance is
positioned relative to the examined breast. Locations of the input and output ports are selected to
examine a tissue region of the breast. Light pulses of a selected wavelength and duration less than a
nanosecond are introduced into the breast tissue at the input port and detected over time at the
detection port. Signals corresponding to photons of detected modified pulses are accumulated over
time. Values of a scattering coefficient or an absorption coefficient of the examined breast tissue
are calculated based on the shape of the modified pulses. The examined breast tissue is
characterized based on the values of the scattering coefficient or the absorption coefficient.
Absorbing or fluorescing contrast agents may be introduced into the examined tissue. This method
may be used in conjunction with x-ray mammography, needle localization procedure or MRI
mammography.
Composition providing a lasting cosmetic and/or pharmaceutical treatment of the upper epidermal layers
by topical application on the skin
A composition containing, in a suitable carrier, nanoparticles of one or more nonbiodegradable
polymer(s) encapsulating an oily phase which contains at least one active oil and/or at least one
carrier oil and/or at least one active ingredient in an active oil and/or a carrier oil. At least one
active ingredient is chosen from those with prolonged cosmetic and/or pharmaceutical activity. The
nanocapsules have a size of 100-1000 nm.
Sunscreen agents
Hydroxy salts of formula: where M is zinc, copper or a mixture of the two and X denotes anions at
least some of which display ultraviolet absorption over at least a portion of the wavelength range
from 290 to 400 nanometers, their use as sunscreen agents and sunscreen compositions comprising
them together with a cosmetically acceptable vehicle.
Solid fat nanoemulsions as drug delivery vehicles
The present invention provides pharmaceutical compositions comprising nanoemulsions of
particles comprising a lipid core which is in a solid or liquid crystalline phase at 25.degree. C,
stabilized by at least one phospholipid envelope, for the parenteral, oral, intranasal, rectal, or
topical delivery of both fat-soluble and water-soluble drugs. Particles have a mean diameter in the
range of 10 to 250 nm. A wide variety of drugs and oxygen transporting perfluorocarbons may be
encapsulated in the particles. In addition to drug delivery vehicles, the invention provides oxygen
transporting blood substitutes, and nanoemulsions for extracorporeal maintenance of tissues prior to
transplantation.
Treatment of cutaneous vascular and pigmented lesions
According to the invention, a method is provided for disrupting the targeted lesion in skin, such as
is necessary in treatment of vascular or pigmented lesions. A microplasma is generated in a target
region of skin, the microplasma disrupting the skin ("plasma ablation") to enable removal of the
targeted lesion. The microplasma absorbs radiation energy and expands, creating high pressure in
the surrounding region which causes disruption of the targeted lesion in that region. A beam of
pulsed laser radiation can be used to generate the microplasma by properly controlling the peak
irradiance, the pulse duration and the focal spot size of the beam. The invention enables use of a
laser having small pulse energy. A synchronized laser beam scan device can be used to scan the
beam to provide a highly efficient system for rapid skin treatment.
Utilization of derivatives of 2,5 dihydroxyphenyl-carboxylic acid amides and their salts in preparation of
a cosmetic or dermatological composition with a depigmenting action
the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or
##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched
C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more
hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6
or branched C.sub.1 -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when
Blood oximeter
A backscatter type non-invasive blood oximeter utilizes a coherent, polarized and tuneable
monochromatic light source to measure parameters related to blood oxygen content. A
microprocessor calculates information related to blood oxygen content from the sensed information
and a display system displays the blood oxygen content.
Method for treating pigmentation abnormalities using pulsed laser radiation with an elongated crosssection and apparatus for providing same
A method for treating pigmentation abnormalities in human skin involves the use of a beam of laser
radiation having an elongated cross-sectional area. The beam of pulsed laser radiation having an
elongated cross-section is produced using a pulsed laser and a delivery system. An elongated area
on the skin including a pigmentation abnormality is irradiated with the laser beam. The laser pulse
parameters are tailored to the specific type of pigmentation abnormality (e.g., vascular lesions or
tattoos) being treated. The beam may have a cross-sectional area characterized by an aspect ratio of
greater than two. Also, the beam may have an elliptical cross-sectional area.
Photoprotective/cosmetic compositions comprising 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5triazine andoily esters
Topically applicable sunscreen/cosmetic compositions having improved cosmetic properties and
well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of
UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective
amount of 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) at least one oil
selected from among the esters of the structural formulae (I), (II) and (III): ##STR1## in a
Photoprotective/cosmetic compositions comprising at least one solid organic sunscreen compound and
diphenylacrylate solvent therefor
solar radiation, comprise (i) a photoprotecting effective amount of 4-methylbenzylidenecamphor
and, optionally, of 4-(tert-butyl)-4'-methoxydibenzoylmethane and (ii) a 2-ethylhexyl .alpha.cyano-.beta.,.beta.-diphenylacrylate sunscreen solvent, in an amount sufficient to substantially
completely dissolve the total amount of the sunscreen constituent (i), in a cosmetically acceptable
Photoprotective/cosmetic compositions comprising UV-A and/or UV-B sunscreens and polymers
compatible therewith
solar radiation, comprise (i) a photoprotecting effective amount of at least one organic or inorganic
UV screen, or mixture thereof, and (ii) at least one polymer compatible therewith, said at least one
polymer comprising recurring structural units of the following formula (I) and recurring structural
units of the following formulae (II) and/or (III): ##STR1## in a cosmetically acceptable vehicle,
diluent or carrier therefor which comprises a continuous aqueous phase.
solar radiation, comprise a photoprotecting synergistically effective amount of (i) benzene-1,4-di(3methylidene-10-camphorsulfonic)acid, optionally either partially or totally neutralized, and (ii) 2ethylhexyl .alpha.-cyano-.beta.,.beta.-diphenylacrylate, in a cosmetically acceptable vehicle, diluent
Cosmetic compositions containing a synergistic mixture of conditioning polymers
The invention relates to new cosmetic compositions based on a synergistic mixture of conditioning
polymers chosen from at least one quaternary polyammonium polymer (a) consisting of a sequence
of units corresponding to the following formula (I): ##STR1## in which p is an integer ranging
from 1 to 6, D may not exist or can represent a --(CH.sub.2).sub.r --CO-- group in which r denotes
a number equal to 4 or to 7, X.sup.- is an anion derived from an inorganic or organic acid, where
the molecular mass of the polymer (a) is less than 100,000 and at least one polymer (b) consisting
of 70% to 90% by weight of diallyldialkylammonium units in which the alkyl radical contains from
1 to 18 carbon atoms and of 30% to 10% by weight of acrylic or methacrylic units, and to their use
for washing or for caring for the hair and/or the skin.
Storage-stable, ultrafine oil-in-water emulsion nanopigmented sunscreen/cosmetic compositions
Stable and homogeneous, topically applicable sunscreen/cosmetic compositions well suited for the
photoprotection of human skin and/or hair against the damaging effects of UV-A and/or UV-B
irradiation, particularly solar radiation, and which display excellent transparency on the skin,
comprise a storage-stable, ultrafine oil-in-water emulsion of a photoprotecting effective amount of
homogeneously and finely dispersed particulates of at least one inorganic nanopigment which
comprises a metal oxide, for example titanium dioxide, wherein the average particle size of the
globules comprising the oily phase of the emulsion characteristically range from 100 nm to 1,000
nm.
Photostable filtering cosmetic composition containing a UV-A filter and a filtering polymer of the
benzotriazole silcone type
A photostable, filtering cosmetic composition for protecting human epidermis and hair against UV
rays comprises, in a cosmetically acceptable carrier having at least one fatty phase 0.5 to 4% by
weight of 4-(tert.-butyl) 4'-methoxy dibenzoylmethane and 0.1 to 20% by weight of a filtering
polymer of the benzotriazole silicone type containing at least one unit of formula (1), where R' is a
C.sub.1 -C.sub.30 hydrocarbon group, a C.sub.1 -C.sub.8 halogenated hydrocarbon group or a
trimethylsilyloxy group; a is 1 or 2; X=--A--Y where A is an aliphatic or aromatic bivalent
hydrocarbon radical having at least 2 carbon atoms and optionally containing one or more oxygen
atoms; Y is a 2-(2'-hydroxyphenyl)benzotriazole residue optionally containing one or more C.sub.1
-C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, halogen, alkoxy, carboxy, hydroxy or amino substituents,
the weight ratio of the benzotriazole silicone to the 4-(tert.-butyl) 4'-methoxy dibenzoylmethane
being between 1 and 10.
Photoprotective/cosmetic compositions comprising antioxidants and filamentous bacterial extracts
human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, whether
before, during and/or after exposure to such UV irradiation, particularly solar radiation, comprise a
photoprotecting effective amount of (i) at least one antioxidant, for example tocopherol or
derivative thereof, and (ii) at least one extract of at least one nonphotosynthetic and nonfructifying
filamentous bacteria, for example of the order Beggiatoales, in a cosmetically acceptable vehicle,
Screening cosmetic compositions containing a hydrophilic agent comprising at least one sulphonic acid
radical
The invention relates to screening cosmetic compositions containing at least one hydrophilic agent
which screens ultraviolet radiation and contains at least one sulphonic acid radical --SO.sub.3 H
and at least one amino-functional silicone derivative. Application to the protection of skin and hair
against the effects of ultraviolet radiation.
Screening cosmetic composition containing a mixture of 1,4-benzenedi(3-methylidene-10-camphosulfonic)
acid, partially or completely neutralized, and metal oxide nanopigments
The invention relates to a screening cosmetic composition comprising, in a mixture, 0.5 to 10% by
weight of metal oxide nanopigments chosen from titanium, zinc, cerium or zirconium oxide or
mixtures thereof, with a mean diameter of less than 100 nm, and 0.1 to 10% by weight of 1,4benzenedi(3-methylidene-10-camphosulfonic) acid or one of its alkali metal, ammonium, amine,
alkanolamine, Ca, Zn, Mg, Ba, Al or Zr salts, in a cosmetically acceptable carrier. This composition
is useful as composition for protecting the human epidermis or the hair against UV rays or as makeup.
Cosmetic compositions and their uses
New cosmetic compositions characterized in that they comprise, in a cosmetically acceptable
carrier, at least one pseudolatex based on a multiblock polycondensate which contains a
polysiloxane block and a polyurethane and/or polyurea block, wherein the polyurethane and/or
polyurea block further comprises anionic or cationic groups. These compositions can be employed
especially in the cosmetic field of hair care, of make-up or of skin care.
The present invention relates to a method of hair depilation comprising the steps of providing an
augmentation compound that readily absorbs a selected wavelength of laser light energy,
encapsulating the augmentation compound within a liposimal carrier, applying an effective amount
of the encapsulated augmentation compound to a region of tissue to be depilated sufficient to cause
the compound to accumulate within the dermis surrounding each hair follicle and respective
papilla, providing a laser light applicator capable of producing a wavelength of energy matched to
the selected wavelength of absorption for the augmentation compound, positioning the laser light
applicator above the region of skin treated with the augmentation compound and, applying a pulse
of laser energy of the selected wavelength to the region of skin treated with the augmentation
compound, the pulse of laser energy having a radiant exposure dose of sufficient energy and
duration to cause damage to the hair follicle and papilla so that hair regrowth is prevented and
surrounding tissue remains undamaged.
Method and apparatus for debeaking poultry
The present invention relates to debeaking turkey and chick poultry through non-contact thermal
transfer from a source of high frequency heat generating radiation. The present invention directs
heat onto the upper beak of a live bird by convection or radiation to thereby affect the continued
growth of the beak. Such heating of the bird's upper beak provides a debeaking method which
allows the bird's upper beak to stay in place for several days allowing the bird to eat and drink.
Heating the portion of the upper beak also allows the poultry tongue and lower beak to be shielded
from the heat causing less trauma and injury to the bird. The heat may be directed onto the poultry
upper beak by radiation or convection.
Dermatological laser treatment system with electronic visualization of the area being treated
A hand held microsurgical instrument for applying laser energy to selected locations (sites) in an
area under the skin (or other exposed translucent tissue) to provide localized photothermolysis of
underlying tissue at these sites, is described. The laser energy is focused into a spot within the
tissue. This spot is of sufficiently small size so that the energy density is sufficient to provide
surgical or treatment effects within the tissue without damaging the surface tissue. In dermatology,
for example, the technique can be used to destroy endothelial cells in blood vessels which are
desired to be removed, such spider veins (nevi) in the skin, hair follicles to prevent hair growth
therefrom, or other microsurgical procedures. The area is visualized while the laser beam is steered,
using a deflection system, in X and Y coordinates. A telecentric optical system, in which a mirror
of the deflection system is located, directs the laser light essentially perpendicular to the area to be
treated as the beam is scanned over the area. The optical system also focuses illumination light
reflected from the area to a sensor matrix of a CCD video camera. The reflected illumination light
is imaged essentially parallel to the optical axis in the object space thereby providing a precise,
high resolution image corresponding to the area. The laser beam may be tracked as it is deflected
over the area to the selected locations by visualization thereof on a display or monitor associated
with the video camera. The locations are then apparent to the treating physician who can then effect
an increase of the beam power or turn the beam on so as to treat the tissue in the selected locations.
Photoprotective/cosmetic compositions comprising synergistic admixture of sunscreen
compounds/nanopigments
solar radiation, comprise a photoprotecting synergistically effective amount of (i) 2,4,6-tris[p-((2'ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and benzene-1,4-di(3-methylidene-10camphorsulfonic)acid, optionally either partially or totally neutralized, together with
photoprotecting synergistically effective amounts of (ii) particulates of at least one inorganic
nanopigment which comprises a metal oxide, in a cosmetically acceptable vehicle, diluent or carrier
therefor.
Cosmetic or dermatological composition comprising an oil-in-water emulsion based on oily globules
provided with a lamellar liquid crystal coating
Cosmetic or dermatological compositions comprising an oil-in-water type emulsion containing oily
globules which are coated with a lamellar liquid crystal coating and are dispersed in an aqueous
phase, in which each oily globule contains at least one lipophilic compound which is cosmetically
or dermatologically active and is individually coated with a monolamellar or oligolamellar layer of
at least one lipophilic surface-active agent, at least one hydrophilic surface-active agent, and at least
one fatty acid, the coated oily globules having a mean diameter of less than 500 nanometers,
preferably less than 200 nanometers, and the oily phase contains a basic agent in the dissolved
state, exhibit good skin and hair penetration.
Solid fat nanoemulsions
The present invention provides pharmaceutical compositions comprising nanoemulsions of
particles comprising a lipid core which is in a solid or liquid crystalline phase at 25.degree. C.,
stabilized by at least one phospholipid envelope, for the parenteral, oral, intranasal, rectal, or
topical delivery of both fat-soluble and water-soluble drugs. Particles have a mean diameter in the
range of 10 to 250 nm. A wide variety of drugs and oxygen transporting perfluorocarbons may be
encapsulated in the particles. In addition to drug delivery vehicles, the invention provides oxygen
transporting blood substitutes, and nanoemulsions for extracorporeal maintenance of tissues prior to
transplantation.
Sprayable compositions containing dispersed powders and methods for using the same
Stable, sprayable compositions suitable for topical application to human skin or hair are provided,
along with a method for their preparation. The compositions comprise water-in-oil emulsions and a
variety of substantially insoluble dispersed powder. The compositions are useful for applying color
to human skin or hair, for protecting human skin from ultraviolet radiation, and for treating human
skin or hair with a dermatologically active agent. The compositions have unique suspending power,
stability and dispersibility for water-in-oil emulsions.
Photoprotective/cosmetic compositions comprising at least one solid organic sunscreen compound and
salicylate solvents therefor
solar radiation, comprise (i) a photoprotecting effective amount of at least one of the sunscreen
compounds 4-methylbenzylidenecamphor and/or 4-(tert-butyl)-4'-methoxydibenzoylmethane and
(ii) at least one homomenthyl and/or octyl salicylate sunscreen solvent, in an amount sufficient to
substantially completely dissolve the total amount of the at least one sunscreen compound (i), in a
Derivatives of 2,5-dihydroxyphenylcarboxylic acids, and their utilization in cosmetic or dermatological
compositions with a depigmenting action
the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or
##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched
C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more
hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 This document was prepared by www.FormulaScan.com. Its reproduction in any type of form or format is strictly prohibited without
C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6
or branched C.sub. -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when
Topical preparation containing a suspension of solid lipid particles
An aqueous suspension of solid lipoid nanoparticles, comprising at least one lipid and preferably
also at least one emulsifier, for topical application to the body, is provided. The solid lipoid
nanoparticles have a mean particle size of between 50-1000 nm and their concentration is between
0.01-60 wt %, by weight of the suspension. Also topical preparations, comprising said suspension
of solid lipoid nanoparticles, are provided. A medicament can be incorporated into the continuous
phase of the suspension or in a vehicle, which is added to said suspension. The invention further
provides manufacturing methods for the aqueous suspension of solid lipoid nanoparticles as well as
for preparations comprising such suspension.
Stable nanopigmented sunscreen/cosmetic compositions
comprise a storage-stable, ultrafine oil-in-water emulsion resistant to phase separation/settling, of a
photoprotecting effective amount of homogeneously and finely dispersed particulates of at least one
inorganic nanopigment which comprises a metal oxide, for example titanium dioxide, as well as a
stabilizing amount of at least one mixed silicate which comprises alkali and/or alkaline earth
metals, and further wherein the average particle size of the globules comprising the oily phase of
the emulsion characteristically ranges from 100 nm to 1,000 nm.
EMI protected aircraft
A device for shielding aircraft avionics and other electronic equipment from electromagnetic
radiation generated by electronic devices used aboard the aircraft. The device includes a contiguous
conductive shield which can be of wire mesh and which partially or completely surrounds a
compartment or compartments of the aircraft, such as the passenger compartment and cargo
compartments, and absorbs and dissipates the electromagnetic radiation which originates in the
compartment from the electronic devices. The aircraft windows are also shielded with the
conductive shield or, alternatively, may be coated with a transparent thin conductive polymer to
allow better viewing.
Artificial tanning compositions comprising dihydroxyacetone/alkylpolysaccharides/fatty alcohols
Improvedly stable and effective, topically applicable cosmetic compositions well suited for
artificially tanning and/or darkening human skin, comprise, in a cosmetically acceptable vehicle,
diluent or carrier therefor, an effective artificial tanning amount of dihydroxyacetone, in immixture
with at least one alkylpolysaccharide and at least one fatty alcohol, and, optionally, at least one
polysaccharide.
Arginine derivatives, process of preparation, uses, and compositions comprising them
New arginine derivatives containing an N.sup..alpha. -alkyloxycarbonyl group of formula (I)
##STR1## in which R represents a linear or branched alkyl radical having from 8 to 22 carbon
atoms, salts thereof, and mixtures of the derivatives and the salts. A process for the preparation of
these derivatives, salts, and mixtures and use of such derivatives, salts, and mixtures, especially in
cosmetics. Compositions, especially cosmetic compositions, comprising the derivatives, salts, and
mixtures.
Lysine derivatives, process of preparation, uses, and compositions comprising them
New lysine derivatives containing a containing an alkylsulphonyl or alkylaminocarbonyl group of
formula (I): in which X represents an --SO.sub.2 R or --CONHR group, where R represents a linear
or branched, saturated or unsaturated, alkyl radical having from 8 to 22 carbon atoms, salts thereof,
and mixtures of the derivatives and the salts. A process for the preparation of these derivatives,
salts, and mixtures and use of such derivatives, salts, and mixtures, especially in cosmetics.
Compositions, especially cosmetic compositions, comprising the derivatives, salts, and mixtures.
Lysine derivatives, process of preparation, uses, and compositions comprising them
New lysine derivatives containing a fluoroalkyloxycarbonyl or fluoroalkylsulphonyl group of
formula: in which n ranges from 0 and 4, X represents a divalent COO or SO.sub.2 group and R
represents a linear or branched perfluoroalkyl radical having from 4 to 20 carbon atoms, salts
thereof, and mixtures of the derivatives and the salts. A process for the preparation of these
derivatives, salts, and mixtures and use of such derivatives, salts, and mixtures, especially in
cosmetics. Compositions, especially cosmetic compositions, comprising the derivatives, salts, and
mixtures.
Screening cosmetic composition containing a mixture of 1,4-benzenedi(3-methylidene-10-camphosulfonic)
acid, partially or completely neutralized, and metal oxide nanopigments
Screening cosmetic composition containing a mixture of 1,4-benzenedi (3-methylidene-10camphosulfonic) acid, partially or completely neutralized, and metal oxide nanopigments
Cosmetic composition which prevents or attenuates the photo-reactivity of titanium dioxide
nanopigments
Cosmetic composition, characterized in that it contains titanium dioxide nanopigments coated with
at least aluminium derivatives in a cosmetically acceptable, fairly nonpolar medium having a
conductivity of less than 100 .mu.Siemens and containing at least one fatty phase.
Cosmetic composition containing a mixture of metal oxide nanopigments and melanine pigments
The invention relates to a cosmetic composition comprising, in a mixture, 0.10 to 15% by weight of
metal oxide nanopigments chosen from titanium, zinc, cerium or zirconium oxide or mixtures
thereof, with a mean diameter of less than 100 nm, and 0.001 to 2% by weight of melanin pigments
derived from natural or synthetic sources with a mean diameter of between 10 and 20,000 nm, in a
cosmetically acceptable carrier. This composition is useful as a composition for protecting the
human epidermis or the hair against UV rays or as make-up.
Spectroscopic burn injury evaluation apparatus and method
A burn evaluation apparatus and related method, that allows a surgeon to make a quick evaluation
of the extent and depth of a skin burn injury by employing induced ultraviolet or blue light
fluorescence spectroscopy and visible and infrared reflectance spectroscopy. The apparatus
monitors the condition of the structural and metabolic constituents in the injured skin. The
apparatus includes a plurality of light sources, a sensor, a microprocessor, and several optical fiber
bundles. The light sources emit excitation light at predetermined wavelengths, and when each is
activated, the sensor measures the amount return light received within several wavelength bands of
interest. A side fiber bundle spaced about a centimeter from a main fiber bundle assists in detecting
tissue water below the burn area. By optically evaluating the skin at the burn site, the apparatus
prevents the unnecessary removal of viable skin that will heal spontaneously within a few weeks,
thereby reducing the amount of skin that must be surgically grafted.
Spontaneously formed clear silicone microemulsions
A method of spontaneously forming a highly stable clear microemulsion by combining (i) water;
(ii) a volatile cyclic methyl siloxane or volatile linear methyl siloxane; and (iii) a silicone polyether
surfactant. The amounts of each component are such that the composition is in the form of a
microemulsion. The volatile methyl siloxane is present in the microemulsion in the form of
particles having an average diameter of less than about 100 nanometers. The microemulsion is
useful in personal care products.
Laser assisted drug delivery
The present invention provides a process for laser assisted drug delivery through the skin. A drug
and a explosive absorber of light energy are applied topically to the skin. The treated area of the
skin is illuminated with very short pulses of light which is preferentially absorbed by the absorber
causing a very large number of tiny explosions. The tiny explosion forces portions of the drug to
penetrate into the skin. A preferred embodiment utilizes small graphite particles and an Nd:YAG
short pulse laser.
formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(i): ##STR2## and
Depigmenting cosmetic or dermatologic composition containing a benzofuran derivative and its use in
depigmentating skin
A depigmenting cosmetic or dermatologic composition for use in bleaching the skin or treating
pigmental spots contains in a vehicle suitable for topical application to the skin a benzofuran
derivative having the formula ##STR1## wherein the OH function occupies position 5 or 6,
R.sub.1 and R.sub.2, each independently, represent hydrogen or alkyl having 1-4 carbon atoms, n is
0 or 1, when n is 0, the C.sub.2 -C.sub.3 bond is a double bond, and when n is 1, the C.sub.2 C.sub.3 bond is a single bond.
Nanopigmented sunscreen/cosmetic compositions
nm.
Cleaning compositions including derivatized guar gum composition including nonionic and cationic
groups which demonstrate excellent solution clarity properties
A detergent composition useful for cleaning and/or conditioning human hair or skin or cleaning
dishes or clothing which contains NaCl or NH.sub.4 Cl and further contains a nonionically and
cationically derivatized polygalactomannan, the molecular substitution of the nonionic substituent
being between about 0.4 and about 1.2 and the degree of substitution of the cationic substituent
being between about 0.20 to about 1.0, said detergent composition having a viscosity of greater
than about 500 centipoises and said composition having greater than 75% light transmission at a
wavelength of from about 500-600 nanometers is provided. Also disclosed is the use of an
amphoteric and nonionic substituted derivatized polygalactomannan for such uses.
Screening cosmetic composition comprising one nanopigment of metallic oxide and fat-soluble screening
polymer
This invention relates to a filtering cosmetic composition characterized in that it is comprised, in a
cosmetically acceptable carrier, at least one nanopigment of metal oxides selected amongst
titanium, zinc, cerium, zirconium, iron oxides or mixtures thereof, having an average diameter
lower than 100 nm, and at least one polymer carrying at least one ultraviolet absorbing group
selected amongst liposoluble polymers having a hydrocarbonated structure and the polymers of
siloxanic structure and such compositions are useful for the protection of human epidermis and hair
against UV radiation or as make-up composition.
Dihydroxyacetone-based emulsion and its use in cosmetics
Stable skin coloring cosmetic emulsion comprising A) from 50 to 92% by weight, based on the
total emulsion weight, of an aqueous phase containing from 0.5 to 10% by weight, based on the
total emulsion weight, of dihydroxyacetone and B) from 8 to 50% by weight, based on the total
emulsion weight, of a fatty phase comprising from 5 to 15% by weight of isoparaffin or poly.alpha.-olefin, from 3 to 7% by weight of an emulsifying agent consisting of a mixture of saturated
or unsaturated sorbitol and glycerol esters of C.sub.18 fatty acids with a straight or branched chain,
optionally including hydroxyl, said esters being oxyethylenated and oxypropylenated, the total
number of ethylene oxide and propylene oxide being less than or equal to 5, and from 0 to 15% by
weight of the additional fatty bodies, all of the percentages being based on the total emulsion
weight. The water-in-oil emulsion can be used to obtain a triple water-in-oil-in-water emulsion.
Aromatic dibenzofuran compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active dibenzofuran compounds have the structural formula
(I): ##STR1## wherein Ar is a radical having one of the formulae (II) to (VI): ##STR2## and are
useful for the treatment of a wide variety of disease states, whether human or veterinary, for
Hair removal method
The present invention provides a process for the destruction of unwanted human hair. Hair ducts in
a section of skin in which the unwanted hair are growing is contaminated with a contaminant
having a high absorption at at least one frequency band of light. The skin section is then illuminated
with light at the frequency band of high absorption so as to impact sufficient energy to the
contaminant so as to cause death to the hairs growing in the ducts. In a preferred embodiment the
contaminant is a mixture of 1 micron graphite particles in mineral oil and each section is
illuminated with about 5 laser pulses at 1.06 micron wavelength produced by a Nd:YAG laser, each
pulse having an energy density of about 3 Joules/cm.sup.2 and a pulse width of about 10
nanoseconds. In another preferred embodiment the hairs in the section of skin being treated are
pulled out prior to application of the contaminant so as to provide more space for the contaminant
in the hair duct. In still another preferred embodiment a portion of the hairs below the skin surface
is removed with a depilatory. In still another preferred embodiment C.sub.60 molecules, buckey
balls, are the absorbing elements in the contaminant.
Hair removal method
A process for the long term or permanent prevention of growth of unwanted hair. The upper
portions of hair ducts (i.e. portions near the skin surface) in a section of skin are infiltrated with a
contaminant having a high absorption at at least one frequency band of light. The skin is then
illuminated using a process having at least two distinct phases. In a "mechanical" phase the skin
section is illuminated (e.g., by a laser) with at least one short pulse of light sufficient to cause tiny
explosions in the contaminant forcing portions of the contaminant more deeply into the hair ducts.
During a "thermal" phase the skin section is then illuminated so as to heat the contaminant
substantially without further explosion or vaporization of the contaminant. The hot contaminant
heats portions of the skin tissue immediately surrounding the contaminant to a temperature high
enough and for a long enough period of time to devitalize the tissue. The process may also include
a "cleanup" phase, during which the skin section is illuminated with a few short pulses of light to
cause additional explosions in and vaporization of portions of the contaminant then remaining in
the ducts and additional damage to the skin tissue immediately surrounding the contaminant.
solar radiation, comprise a photoprotecting synergistically effective amount of (i) 1,4-benzene
[di(3-methylidene-10-camphosulfonic)] acid, optionally either partially or totally neutralized,
together with a photoprotecting synergistically effective amount of (ii) a benzotriazole-substituted
polyorganosiloxane, in a cosmetically acceptable vehicle, diluent or carrier therefor.
Transparent nanoemulsion less than 100 NM based on fluid non-ionic amphiphilic lipids and use in
cosmetic or in dermopharmaceuticals
An oil-in-water nanoemulsion in which the oil globules have a mean size of less than 100 nm and
which contains an amphiphilic lipid component containing at least one non-ionic amphiphilic lipid
which is liquid at an ambient temperature of less than 45.degree. C. The nanoemulsion can be used
in the fields of cosmetics and dermopharmaceuticals. The nanoemulsion is stable on storage, can
contain significant amounts of oil while retaining good transparency, and can contain heat-sensitive
active agents.
Method for preparing storage-stable, ultrafine oil-in-water emulsion nanopigmented sunscreen/cosmetic
compositions
nm.
Liquid delivery compositions
Improved biocompatible liquid delivery compositions, which are useful for the formation of
sustained release delivery systems for active agents, are provided. The compositions include liquid
formulations of a biocompatible polymer or prepolymer in combination with a controlled release
component. The controlled release component includes an active agent. These compositions may be
introduced into the body of a subject in liquid form which then solidify or cure in situ to form a
controlled release implant or a film dressing. The liquid delivery compositions may also be
employed ex situ to produce a controlled release implant. Methods of forming a controlled release
implant and employing the liquid formulations in the treatment of a subject are also provided.
H.sub.2 O-resistant sunscreen/cosmetic compositions comprising hydrophilic acidic species
Improvedly water-resistant sunscreen/cosmetic compositions, well suited for the prolonged UVphotoprotection of human skin and hair, comprise a cosmetically acceptable oil-in-water emulsion
containing (i) at least one hydrophilic compound that screens ultraviolet irradiation and which
comprises at least one optionally neutralized acid functional group, for example at least one
optionally neutralized sulfonic acid or carboxylic acid functional group, and (ii) at least one
insoluble filler material that is both inert with respect to said at least one hydrophilic acid
compound (i) and an adsorbent therefor.
Photoprotective/cosmetic compositions comprising TiO.sub.2 nanopigments and acylamino acids
Novel photoprotective/cosmetic photocoloration-resistant compositions, well suited for the
photoprotection of human skin and/or hair, comprise an effective UV-screening amount of at least
one titanium dioxide nanopigment and an effective photobluing-reducing amount of at least one
ionic amphiphilic lipid which comprises an acylamino acid, in a cosmetically acceptable vehicle
therefor.
screening polymer
Liquid delivery compositions
Improved biocompatible liquid delivery compositions, which are useful for the formation of
sustained release delivery systems for active agents, are provided. The compositions include liquid
formulations of a biocompatible polymer or prepolymer in combination with a controlled release
component. The controlled release component includes an active agent. These compositions may be
introduced into the body of a subject in liquid form which then solidify or cure in situ to form a
controlled release implant or a film dressing. The liquid delivery compositions may also be
employed ex situ to produce a controlled release implant. Methods of forming a controlled release
implant and employing the liquid formulations in the treatment of a subject are also provided.
Personal cleansing compositions
Twisted pairs communications cable
There is disclosed a communications cable having a cable jacket and a first pair of twisted wires
disposed within the jacket, each wire thereof having a conductor surrounded by a first insulating
material. A second twisted pair of wires is disposed within the jacket and has a twist lay length
different from that of the first twisted pair. Each wire of the second twisted pair has a conductor
surrounded by an insulating material. The insulating material of the first twisted pair differs in a
physical property from the insulating material of the second twisted pair, the physical property of
the insulating material of the second pair being correlated with the physical property of the
insulating material of the first twisted pair and with differences in twist lay length of the first and
second twisted pairs so that the phase delay of the twisted pairs is matched. There is also provided a
communications cable having more than two twisted pairs. The insulating materials include
polyolefins such as polyethylene, and fluorinated polymers such as fluorinated ethylene-propylene.
The insulating material may be used as either a solid or foamed material covering the conductor.
These insulated wires may be used in the transmission of electronic signals in a plenum-rated
communications cable.
Photochemistry for the preparation of biologic grafts--allografts and xenografts
Photodynamic therapy (PDT), a technique to produce cytotoxic free radicals, was used to prepare
arterial allografts. After impregnation with the photo-sensitizer chloroaluminum sulfonated
phthalocyanine, aortas of ACI rats were PDT-treated and transplanted in Lewis rats. PDT grafts
were completely reendothelialized by 4 weeks.
Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery
The present invention comprises a method of transdermal drug delivery where a drug is contained
in or must pass through a hydrogel or lipogel together with an enhancement method to improve
mass transfer through the skin, the improvement comprising applying a means for enhancing mass
transfer of the drug through the hydrogel or lipogel to the skin.
Stabilization of colloidal systems through the formation of lipid-polyssacharide complexes
Stabilization of colloidal systems through the formation of lipid-polyssacharide complexes.
Development of a procedure for the preparation of colloidal systems involving a combination of
two ingredients: a water soluble and positively charged polyssacharide and a negatively charged
phospholipid. Colloidal systems (submicron emulsions and polymeric nanoparticles and
nanocapsules) are stabilized through the formation, at the interface, of an ionic complex:
aminopolyssachride-phospholipid. These colloidal systems are characterized by their positive
charge and their improved stability. Furthermore, they can be freeze-dried, stored in a dry state and
hydrated when required. They can be interesting systems for the administration of drugs by the
oral, transdermal, ocular, nasal and vaginal routes of administration. In addition, they can be of
interest for cosmetic use.
Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the
structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-or --Nr'-- and Ar is either a radical having the following structural formula (II): ##STR2## or a
radical having the following structural formula (III): ##STR3## and are useful for the treatment of
a wide variety of disease states, whether human or veterinary, for example dermatological,
Compounds derived from cyclodextrin
The invention relates to cyclodextrin derivatives of formula (I) in which each R.sub.1
independently denotes a C.sub.6 -C.sub.24 alkyl radical or a C.sub.8 -C.sub.24 alkenyl radical,
each R.sub.2 independently denotes a C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl
radical, and I, m and n are statistical values. The invention also relates to a process for the
preparation of the compounds of formula (I) and to the use of these compounds in cosmetics.
Artificial tanning compositions comprising dihydroxyacetone
Stable and homogeneous, topically applicable cosmetic compositions well suited for artificially
tanning human skin, comprise a storage-stable, ultrafine oil-in-water emulsion, devoid of lipid
vesicles, containing an effective artificial tanning amount of dihydroxyacetone, and further wherein
the average particle size of the globules comprising the oily phase of the emulsion characteristically
ranges from 100 nm to 1,000 nm.
screening polymer
Photoprotective compositions comprising mutually incompatible oily dispersed phases
Topically applicable, water resistant cosmetic/dermatological compositions well suited for
enhanced photoprotection of human skin and or/hair against the damaging effects of UV-A and
UV-B irradiation, particularly solar radiation, comprise (I) a continuous aqueous dispersing phase,
(ii) a first discontinuous globular oily dispersed phase O.sub.1, (iii) a second discontinuous globular
oily dispersed phase O.sub.2, (iv) at least one O/W emulsifying agent, (v) at least one W/O
emulsifying agent, (vi) a photoprotecting effective amount of at least one lipophilic UV screening
agent, (vii) a photoprotecting effective amount of at least one hydrophilic screening agent, said first
and second oily phases O.sub.1 and O.sub.2 being mutually incompatible, and the globules
constituting said oily phase O.sub.1 having an average size which is different from the globules
constituting said oily phase O.sub.2.
Filament lamp for dermatological treatment
Thermal modification of dermatological tissue using non-laser infrared light energy. A high energy
incandescent-type lamp, such as a quartz tungsten halogen lamp, operated in a pulsed mode with a
high voltage input, creates a particular energy output. Applications of such apparatus and methods
include treatment of the dermis and/or sub-epidermal tissues for the purpose of skin recontouring,
thermal destruction of hair follicles for the purpose of hair removal, and others.
Localization of abnormal breast tissue using time-resolved spectroscopy
A method of breast tissue examination using time-resolved spectroscopy includes the following
steps. A support that includes an input port and an output port separated by a selected distance is
positioned relative to the examined breast. Locations of the input and output ports are selected to
examine a tissue region of the breast. Light pulses of a selected wavelength and duration less than a
nanosecond are introduced into the breast tissue at the input port and detected over time at the
detection port. Signals corresponding to photons of detected modified pulses are accumulated over
time. Values of a scattering coefficient or an absorption coefficient of the examined breast tissue
are calculated based on the shape of the modified pulses. The examined breast tissue is
characterized based on the values of the scattering coefficient or the absorption coefficient.
Absorbing or fluorescing contrast agents may be introduced into the examined tissue. This method
may be used in conjunction with x-ray mammography, needle localization procedure or MRI
mammography.
Heterocyclic biaryl compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active heterocyclic biaryl compounds have the structural
formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(h): ##STR2## and
well as for cosmetic applications and for the treatment of mammalian skin and hair
Polycyclic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polycyclic polyenic compounds have the structural
formula (I): ##STR1## and are useful for modulating cellular hormone receptors.
Nanoparticles coated with a lamellar phase based on silicone surfactant and compositions containing
them
The present invention relates to nanoparticles, and in particular nanocapsules, provided with a
lamellar coating obtained from a silicone surfactant, and to their use in a composition, in particular
a topical composition, for treatment of the skin, mucosae, nails, scalp and/or hair.
Hair removal method
A process for the permanent destruction of unwanted human hair. Hair duct in a section of skin in
which the unwanted hair is growing is contaminated with a contaminant having a very large
number of small particles having a high absorption at at least one frequency band of light. The skin
section is then illuminated with a series of short pulses of light at the frequency band of high
absorption, the first of the short pulses having sufficient energy to cause a large number of the
particles to explode into two or more fragments so as to spread said contaminant in the hair ducts
and subsequent pulses having sufficient energy to cause a large number of the fragments to further
explode into additional fragments to further spread the contaminant in the hair duct. The explosions
and energy is transferred to and from the particles and fragments causing damage to skin tissue
surrounding said hair ducts so as to cause death to the hairs growing in the ducts. In a preferred
embodiment the particles are 1 micron graphite particles and each section is illuminated with about
5 laser pulses at 1.06 micron wavelength produced by a Nd:YAG laser, each pulse having an
energy density of about 3 Joules/cm.sup.2 and a pulse width of about 10 nano seconds.
monolamellar or aligolamellar layer obtained from at least one lipophilic surface-active agent, from
Benzalmalonate/phenylcyanoacrylate-substituted s-triazine compounds and photoprotective/cosmetic
compositions comprised thereof
Photoprotective/cosmetic compositions well suited for enhanced photoprotection of human skin
and/or hair, as well as of a wide variety of other photosensitive materials and substrates, e.g.,
inorganic or organic glasses, plastics or the like, against the deleterious effects of UV-A and UV-B
irradiation, particularly solar radiation, comprise a photoprotecting effective amount of a novel
insoluble benzalmalonate/phenylcyanoacrylate-substituted s-triazine compound having the
structural formula (I): ##STR1## in which R.sub.1, R.sub.1 ' and R.sub.1 ", which may be identical
or different, are each a monovalent radical having one of the formulae (A) or (B) below: ##STR2##
UV-Photoprotective cosmetic compositions comprising polymer particulates/fatty phases having unique
refractive indices
Topically applicable cosmetic/dermatological composition well suited for improved
photoprotection of human keratinous substrates, for example human skin and/or hair, comprise (a)
an aqueous phase, (b) at least one fatty phase having a refractive index n.sub.1, (c) an effective UVphotoprotecting amount of at least one water-soluble UV-screening active agent, and (d)
particulates of at least one non-film- forming polymer having a refractive index n.sub.2, and the
refractive indices n.sub.1, and n.sub.2 being selected such that:
screening polymer
Process for the dispersion by high-pressure homogenization of pulverulent fillers in a vehicle composed of
at least one fatty phase, compositions obtained and uses
The present invention relates to a process for the dispersion of at least one pulverulent organic filler
and/or of at least one pulverulent inorganic filler in a vehicle composed of at least one fatty phase,
by mixing the filler or fillers in the vehicle by high-pressure homogenization in one or a number of
passes, to the cosmetic or dermatological compositions capable of being obtained by this process.
The present invention also relates to the use of the compositions obtained by this process as the
basis for care, make-up and/or hygiene products. The present invention also relates to the use of the
compositions obtained by this process as the basis for products for protecting the skin, hair, scalp,
nails, eyelashes, eyebrows and/or mucous membranes against the effects of ultraviolet radiation.
Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation
Pigmentation of the skin, hair and/or nails of individuals is promoted by administering thereto,
advantageously topically and advantageously in combination with enzymes exhibiting tyrosinase
activity, effective pigmentation-promoting amounts of at least one retinoid compound which
comprises a phenolic or naphtholic functional group.
Apparatus for enhanced visual venous examination
An apparatus for aiding in performing operations requiring location of blood vessels such as
intravenous injections or drawing blood in which a charge coupled device camera is focused on an
area of the body such as the arm that is illuminated by a light source which emits light that is partly
in the infrared range and partly in the ultraviolet range but from which light light having a
wavelength in the visible range has been substantially eliminated. The useful range of wavelengths
may be provided by any one of several methods including having an infrared source and an ultra
violet source or an incandescent source emitting wavelengths extending from the infrared to the
ultra violet and having a filter for removing the range of visible light.
UV-photoprotective dibenzoylmethane compositions comprising photostabilizing amounts of
benzalmalonate silanes
Topically applicable, stable, UV-photoprotective cosmetic/dermatological compositions well suited
irradiation, comprise (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane
UV-sunscreen compound and (b) an effective dibenzoylmethane compound (a) photostabilizing
amount of at least one benzalmalonate silane having the structural formula (I): ##STR1##
Passive electronic components from nano-precision engineered materials
Nanosize powders with particle size smaller than the critical length for specific material properties
are used to form the ceramic layers of passive electronic components. Ceramic substrates are
coated with electrodes, which are then coated with a ceramic layer from a suspension, preferably a
low viscosity suspension, of nanoscale powders. The ceramic layer is dried at low temperatures
(preferably below 200 .degree. C.) and it is sintered to high density (preferably above 90%) at
moderate temperatures (preferably low and less than 1,000 .degree. C.). Once sintered, an electrode
layer is coated on top of the ceramic layer to yield an electrode/ceramic/electrode structure.
formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and
are useful for the treatment of disorders and/or ailments manifesting an overregulation of RAR
Electrochemical sensor with dual purpose electrode
The present invention provides an electrode assembly for use in a transdermal analyte sensor
operating in an alternating polarity mode in which a single electrode element provides both the
counter electrode and iontophoretic electrode functions. By combining both the functions of the
iontophoretic and counter electrode, the surface area of the electrode with respect to each function
may be made larger. In turn this increases the ability of the electrode to deliver the required
electrical field over a larger area when operating in the iontophoretic mode as well as increasing the
ability of the counter electrode to compensate for the larger sensing electrode facilitated by this
new design.
Spectrophotometric assay for cyanide
A method of detecting and quantifying cyanide concentration in a patient, by monitoring
photometric changes resulting from the transformation of methemoglobin to cyanomethemoglobin.
The present invention provides for a means of cyanide poisoning assessment in patients using the
affinity of methemoglobin for cyanide to assess the photometric changes resulting from
methemoglobin converting to cyanomethemoglobin, as an indicator of cyanide concentration in a
patient. Appropriate corrective action can then be promptly taken.
Disclosed are personal care compositions which are suitable for application to the hair, skin, or
nails. These compositions comprise a polyorganosiloxane emulsion comprising a surfactant and a
polyorganosiloxane having an average particle size of less than about 150 nanometers; from about
0.01% to about 10% of a silicone-linear polyoxyalkylene block copolymer surfactant; and a carrier
comprising (i) at least about 0.5%, by weight of the composition, of a first solvent selected from the
group consisting of water, water soluble organic solvents, organic solvents which are strongly to
moderately strong in hydrogen-bonding parameter, and mixtures thereof, wherein the solvent is
other than a C.sub.1 -C.sub.3 monohydric alcohol, a C.sub.1 -C.sub.3 ketone, and a C.sub.1 C.sub.3 ether, and (ii) at least about 40%, by weight of the composition, of a second solvent
selected from the group consisting of C.sub.1 -C.sub.3 monohydric alcohols, C.sub.1 -C.sub.3
ketones, C.sub.1 -C.sub.3 ethers, and mixtures thereof. The silicone-polyoxyalkylene copolymer
surfactant provides for improved stability of the polyorganosiloxane emulsion, especially when
lower alcohols such as C.sub.1 -C.sub.3 monohydric alcohols are incorporated into the
compositions.
Pulsed filament lamp for dermatological treatment
A high energy filament lamp light source, such as a quartz tungsten halogen lamp, operated in a
pulsed mode with a high voltage input, creates a particular energy output. Applications of such
apparatus and methods include treatment of the dermis and/or sub-epidermal tissues for the purpose
of skin recontouring, thermal destruction of hair follicles for the purpose of hair removal, and
others, and a method which selectively preheats a subsurface region in targeted tissue to subthermal modification threshold values without significant heat damage to surrounding layers prior
to further treatment.
solar radiation, comprise a photoprotecting synergistically effective amount of (i) 2,4,6-tris[p-((2'ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) 2-ethylhexyl .alpha.-cyano-.beta.,.beta.diphenylacrylate, in a cosmetically acceptable vehicle, diluent or carrier therefor.
Active/stable artificial tanning compositions comprising DHA derivatives
Stable, topically applicable cosmetic/dermatological compositions well suited for artificially
tanning or browning human skin and appropriately packaged, comprise at least one
dihydroxyacetone (DHA) derivative convertible into DHA and, advantageously, at least one active
species for effecting such conversion.
Use of inhibitors of retinoic acid activity for wound healing
A method for promoting healing by administration of an inhibitor of the activity of retinoic acid is
provided. Preferred compounds for use in such treatment include antagonists of retinoic acid. The
method is particularly applicable for promoting skin healing and treatment of surgical and
traumatic wounds.
Common path, interferometric systems and methods using a birefringent material for topographic
imaging
Common path, two beam interferometers and interferometric measurement systems employ a
voltage controlled variable phase retarder enabling rapid stepping of the relative phase between two
interfering optical beams by suitable control of the voltage. The beams need not be laterally
separated. A compact beam expander with a ball lens is preferably included. The system is compact
enough to be contained in a hand-held unit. The system can be used for surface mapping, testing of
optical components and detecting the motion of mechanical objects, for example. It is particularly
well suited for the mapping of the skin of a live subject. An optimum fringe period and optimum
illumination wavelengths for imaging skin are disclosed, enabling the topography of substantial
areas of human skin to be rapidly and accurately measured, in times on the order of one-tenth of a
second. Methods of conducting interferometric analysis are disclosed, as well.
Photoprotective/cosmetic compositions comprising UV-sunscreens/dialkyl tartrates
Novel cosmetic/dermatological UV-photoprotective compositions well suited for enhanced PF
photoprotection of human skin and/or hair comprise (a) an effective UV-screening amount of at
least one benzylidenecamphor sunscreen compound, and/or at least one dibenzoylmethane
sunscreen compound, and/or at least one triazine sunscreen compound, and (b) a PF-enhancing
amount of at least one dialkyl tartrate, formulated into a topically applicable,
Method for glucose sensing
A method for measuring the concentration of glucose diffused from a source to a working electrode
which assembly includes a scavenging electrode is disclosed. The electrode of the invention is
comprised of 1) a working electrode; 2) a scavenging electrode; 3) an electroosmotic electrode; and
4) a electrically insulating gap defined by adjacent edges of 1) and 2) and electrically isolating 1)
and 2). The scavenging electrode substantially reduces or eliminates "edge-effects" or error in
signal transported to the working electrode via a path which includes a radial vector component,
i.e., eliminates chemical signal other than that which moves to the catalytic surface of the working
electrode via a path which is substantially perpendicular to catalytic surface of the working
electrode.
Composition providing a lasting cosmetic and/or pharmaceutical treatment of the upper epidermal layers
by topical application on the skin
A composition containing, in a suitable carrier, nanoparticles of one or more nonbiodegradable
polymer(s) encapsulating an oily phase which contains at least one active oil and/or at least one
carrier oil and/or at least one active ingredient in an active oil and/or a carrier oil. At least one
active ingredient is chosen from those with prolonged cosmetic and/or pharmaceutical activity. The
nanocapsules have a size of 100-1000 nm.
Exothermic effervescent composition for improved fragrance dispersion
An aroma releasing composition has an effervescent agent, an exothermic agent and a volatile
agent, the effervescent agent and exothermic agent provided in a ratio sufficient to promote release
of the volatile agent, when the composition is placed in water. Such a composition has use, alone,
in promoting release of fragrance agents, or in combination with a product, such as a body lotion,
shampoo or liquid soap.
Cosmetic preparations
The cosmetic preparation contains: (a) an oil-soluble active ingredient that is suitable for skin
cosmetics, (b) a partial fatty acid ester of polyoxyethylene sorbitan, (c) at least one phospholipid,
(d) ethanol, and (e) water as a carrier liquid. The phospholipid is dissolved in ethanol, and then the
partial fatty acid esters of polyoxyethylene sorbitan and the active ingredient are added. The oil
phase that is obtained is added to water and stirred. The preparation is obtained in the form of a
nanodispersion.
Antioxidant composition for the treatment of psoriasis and related diseases
The present invention deals with the combination of several synergistic antioxidants including
enzymatic co-factors as adjuncts to therapy of desquamating inflammatory disorders, such as
psoriasis. These topical compositions are aimed to neutralize free radical species generated by such
inflammatory conditions which are responsible for certain clinical signs and symptoms. As such,
damage to skin causing destruction of elastin and collagen tissues is reduced. The present
synergistic antioxidants may be combined with anti-inflammatories, including corticosteroids, antimicrobials, including zinc pyrithione, and other preparations useful in the therapy of desquamating
disorders as psoriasis, seborrhoeic dermatitis and related skin and scalp conditions.
Polychromatic body surface irradiator
A hand-held, self-contained irradiator is powered by batteries. At an applicator end are provided
many diodes that emit electromagnetic radiation in the visible and/or infrared portions of the
spectrum. A series of switches are provided so that the user may select which one or ones of the
diodes to activate to provide particular wavelengths or colors of radiation to be emitted from the
applicator end to be used to treat particular body surface areas for the relief of pain or other
problems. An optional line cord powered embodiment is also disclosed.
Antisan composition containing a solid elastomeric organopolysiloxane
The invention relates to an antisun composition with a high degree of protection, containing watersoluble and liposoluble screening agents, combined with a solid elastomeric organopolysiloxane,
which has noteworthy cosmetic properties. It is in the form of a water-in-oil or oil-in-water
emulsion. The invention also relates to a process for protecting the skin or the lips against solar
radiation, containing this composition.
of laser light having a wavelength which targets the sebum found in the follicle and coating the
hair, heating the sebum which transfer heat first to the hair and hair root and then to the papilla and
papillary blood vessels via conduction, thus destroying the hair by photothermolysis while avoiding
significant damage to surrounding skin or tissue.
Artificial tanning compositions comprising iron oxide nanopigments
Topically applicable cosmetic/dermatological compositions well suited for the persistent and waterresistant artificial tanning and/or darkening of human skin, comprise an effective artificial
tanning/darkening amount of particulates of at least one iron oxide nanopigment, the mean size of
the primary particles of which nanopigment particulates being less than 100 nm, the particulates of
the at least one iron oxide nanopigment being formulated into a vehicle, diluent or carrier therefor
which comprises a water-in-oil emulsion, advantageously a water-in-silicone emulsion, and the
particulates comprising greater than 2% by weight of the total weight of such
cosmetic/dermatological compositions.
Body cleansing composition providing protection against sunburn after rinsing
Disclosed in a body cleansing composition providing upon a single application protection against
sunburn measured by Sun Protection Factor (SPF) of at least 15 as applied and SPF of at least 4,
and preferably at least 5, after rinsing, consisting essentially of water; at icast onc first sunscreen
compound which is a paramethoxycinnamate ester, and at least one second sunscreen compound
able to absorb at least 50% of incident radiation at wave lengths from 290 to 320 nanometers; a
combination of at least two surface active agents including a first anionic agent which can be an
alkyl sulfate salt or an alkoxylated alkyl sulfate salt, and a second agent which can be nonionic,
anionic or zwitterionic; at least one hydroxyethylated organic nitrogen compound fixative to
enhance retention of SPF on the user's skin selected from the group consisting of N-(2hydroxyethyl)lactamide and a polymeric quaternary ammonium salt having a plurality of
quaternary ammonium groups and at least one 2-hydroxyethyl group; and at least one additive
selected firom the group consisting of non-aggressive volatile organic liquids boiling within the
range of 15 to 60.o slashed.C, water-immiscible non-volatile organic carriers, and preservatives
able to retard microbial spoilage, whereby protection against sunburn is imparted to a person in
need thereof in a single application.
Therapeutic method and internally illuminated garment for the management of disorders treatable by
phototherapy
An apparatus for treating neonatal jaundice is in the form of a garment (10, 40) which has
semiconductor light sources (14, 214, 314) affixed thereto for radiating toward the "inside" of the
garment when the infant is dressed in the garment. A portable energy source such as batteries (318)
or a fuel cell (360) powers the array of light sources. A method according to the invention vests the
infant in the garment, and energizes the light sources by coupling a battery to the light sources, or
fueling and starting the fuel cell. The therapy is continued for as long as desired or needed.
Light-screening agents
The invention relates to a composition which comprises a dibenzoylmethane capable of absorbing
UV-A radiation and a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 are
independently hydrogen, alkyl or alkoxy containing 1 to 18 carbon atoms provided that R.sup.1 and
R.sup.2 are not both hydrogen; and n is 1 or 2 in an amount effective to photostabilize the
dibenzolymethane, and a cosmetically acceptable carrier, and to cosmetic light-screening
compositions containing at least one of the above agents, the use of the cosmetic light-screening
compositions for the protection of the human skin and human hair against the ultraviolet radiation
of wavelengths between about 320 and 400 nm (UV-A) and optionally also between about 290 and
400 nm (UV-B).
Stable w/o photoprotective cosmetic emulsions
Stable, water-resistant photoprotective water-in-oil cosmetic emulsions, well suited for the
photoprotection of human skin and/or hair against the deleterious effects of UV irradiation,
comprise an effective stabilizing/emulsifying amount of a pair of active emulsifying agents, said
emulsifying agent pair comprising (i) at least one polyalkylpolyethersiloxane emulsifier substituted
by polyoxyethylene and polyoxypropylene moieties grafted onto the backbone polymer thereof,
and (ii) at least one water-in-oil emulsifying polyoxyalkylenated glycol fatty acid ester polymer.
Polyaromatic amide compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic amides have the structural formula (I):
##STR1## wherein Z is a radical --CO--NH-- or --NH--CO--,and are useful for the treatment of a
Photoprotective cosmetic compositions containing a metal oxide nanopigment and an acrylic terpolymer,
and use of these compositions for protecting keratinous material against ultraviolet radiation
The present application relates to photoprotective cosmetic compositions containing at least one
metal oxide nanopigment and an acrylic terpolymer, as well as to the use of these compositions to
protect the skin, the hair, the eyelashes, the eyebrows or mucous membranes against ultraviolet
radiation. The acrylic terpolymer comprises: a) about 20 to 70% by weight of a carboxylic acid
containing .alpha., .beta.-monoethylenic unsaturation, b) about 20 to 80% by weight of a nonsurfactant monomer containing monoethylenic unsaturation, which is different from a), and c)
about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a
monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation.
The metal oxide nanopigments are chosen in particular from coated or uncoated titanium, cerium,
zirconium, iron and zinc oxide nanopigments, or mixtures thereof, and have an elementary particle
size of greater than 5 nm and less than 100 nm.
Isoflavonoids for treatment and prevention of aging skin and wrinkles
A method of treating or preventing, in a person, one or more symptoms of aging skin, said method
comprising topically administering to the skin of said person a composition comprising one or more
isoflavonoids selected from the group consisting of genistein, daidzein, biochanin A, formononetin,
O-desmethylangolensin, glycitin, and equol, in a topically acceptable base, wherein the
isoflavonoid concentration is between 1 and 40 mg per gram of base.
Topically applied clotting material
A composition, system, articles and method for the enhancement of clotting in wounds with
extravascular blood flow, especially where the surface of the tissue has been broken is described.
The system consists of biotolerable, porous particulates applied to the surface of a wound with
liquid blood thereon. The porous nature of the particulate material, either free-flowing or packaged
or restrained on or in a surface, enhances clotting. Chemical or biochemical agents, such as
additional clotting agents, therapeutic agents, antibiotics, clot strengthening agents (such as fibrous
structural materials), and the like may optionally be included on, with or within the porous
particles. The particles may comprise such diverse materials as organics, metallics, inorganics,
ceramics, and the like, both natural and artificial. It is generally preferred that the pore size
distribution lies within a general range, and this range may vary from animal to animal and
condition to condition, but generally falls within about 0.5 to 1000 nanometers or 3,000 to 200,000
Daltons.
Air bag tear seam and method of manufacture
An air bag cover (14) for use in a supplement inflatable restraint system includes an air bag cover
skin made of a polymeric material. The cover skin includes a weakened tear seam region (16) for
guiding the tearing of the air bag cover skin in response to air bag inflation. The tear seam region is
weakened by photodegradation, i.e., selective exposure to ultraviolet light (20) which breaks
polymer bonds within the polymeric material of the tear seam region. Photodegradation reduces the
tensile strength and/or the percent elongation (measured at break) of the tear seam region (16)
compared to the rest of the air bag cover skin (24).
Hair removal using a contaminant matched to a laser
or the skin tissue feeding the hair. One embodiment to produce death of the follicles or the skin
tissues feeding the hair is by photochemical reaction.
monolamellar or oligolamellar layer obtained from at least one lipophilic surface-active agent, from
Method for treating blood borne viral pathogens such as immunodeficiency virus
A method and apparatus for destroying blood borne pathogens is disclosed which utilizes a low
intensity direct current to generate positive particles from various metals which destroy viral
pathogens. A first electrode comprised of a metal such as silver is inserted into a patient's venous
system. Then, a second electrode is placed on the patient's exterior in the vicinity of the first
electrode. A low intensity direct current is applied to the first metal electrode which releases silver
cations to be bonded to the virus, resulting in the denaturing of the virus. The first electrode is
placed in the venous system of the infected patient via a catheter.
Formulation for use in the prevention of pathogen induced diseases including HIV and HSV
This invention relates to formulations comprising film-forming components capable of forming per
se a physical barrier to pathogens. Thermoreversible gels such as poloxamers are particularly
preferred for that use. The film-forming formulations may further comprise microbicides,
spermicides or any other drug, which choice is guided by the pathogen, organism or the disease to
be inactivated or treated. The formulations are therefore efficient as a physical, and optionally, as a
chemical or pharmacological barrier as well as usable as a sustained drug-release system at the
locus of administration. A part of the drug may also be entrapped in liposomes or other drug
carriers. These formulations are intended for use in the prevention of sexually transmitted diseases,
as well as in the treatment of infections, cancer, inflammation or any disease or state which requires
a pharmacological treatment. Formulations are applicable to mucosae, skin and eye, for example.
Photostable sunscreen compositions comprising dibenzoylmethane compounds and 2hydroxybenzophenone-substituted silanes/organosiloxanes
suited for the photoprotection of human skin and/or hair against the damaging effects of UVirradiation, particularly solar radiation, comprise (1) a UV-photoprotecting effective amount of at
least one dibenzoylmethane sunscreen compound and (2) a photostabilizing effective amount of at
least one silane or organosiloxane bearing a 2-hydroxybenzophenone substituent.
Method for non-invasive wrinkle removal and skin treatment
A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the
epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light
communication with a pulsed dye laser delivery device. The pulsed dye laser delivery device is
applied against tissue having wrinkles. The pulsed dye laser generator generates a pulsed dye laser
light. A pulsed dye laser light from the pulsed dye laser delivery device is directed onto the tissue,
to reach hemoglobin in a collagen layer up to about 1.2 mm. beneath the surface of the tissue to
effect growth changes therein.
Make-up product combining a photochromic pigment and a UV screening agent, and uses thereof
A cosmetic make-up product, comprising first and second components, separately packaged, each
containing a cosmetically acceptable medium, the first component containing at least one
photochromic coloring agent which is capable of producing at least one color in the presence of
ultraviolet light, and the second component containing at least one agent which screens ultraviolet
light.
Boron compounds and complexes as skin-rejuvenating agents
Boron compounds/complexes, other than boric acid and boric acid salts, are utilized for
rejuvenating of skin. The compounds/complexes have a central tetrahedral boron atom covalently
bound to four ligands, which may be either identical or different from each other. Preferred ligands
include an oxygen, nitrogen, carbon or sulfur atom, and more preferred ligands are saccharides or
amino acids that form stable five- or six-membered rings with the boron atom. Especially preferred
compounds have a dissociation constant of at least 3,000, and include a saccharide. Especially
preferred complexes include a sodium, potassium, magnesium or calcium cation. The
compounds/complexes are useful in rejuvenating skin, including decreasing skin wrinkles,
improving skin thickness, increasing skin hydration, softness and elasticity, improving the skin
color, and decreasing the number and size of age spots. The compounds/complexes are preferably
provided in a suitable solvent system, a microemuslion or macroemulsion form, or a suitable
liposome, and may be applied in any suitable form, including creams, bath salts, cosmetics, and
shampoos.
comprised thereof
Use of isoflavonoids in the treatment or prevention of postpartum depression
A method of treating or preventing postpartum depression by administration of a composition
containing one or more purified, naturally-occurring isoflavonoids.
Emulsion compositions, suitable for personal care applications such as hair styling, and other
applications, are disclosed. The compositions comprise: a) a silicone functional polymer having the
formula selected from the group consisting of: (AB).sub.n ; ABA; BAB; ##STR1## and mixtures
thereof; wherein B is a silicone moiety comprising repeating units of: ##STR2## R is
independently, C1-C30 alkyl, aryl, alkylaryl, haloalkyl, H, or C1-C6 alkoxy, wherein the weight
average molecular weight of each silicone moiety B is independently from about 1500 to about
50,000; A is a polar polymeric moiety which is soluble or dispersible in mixtures of ethanol and
water containing less than 60% ethanol by weight; and n is an integer of 1 or greater; wherein the
molecular weight of the silicone functional polymer is at least about 2,000. b) an
organopolysiloxane emulsion comprising: (i) a polyorganosiloxane dispersed as particles in the
emulsion, the polyorganosiloxane having an average particle size of less than about 150
nanometers, and (ii) a surfactant system for dispersing the organopolysiloxane in the emulsion; c) a
carrier comprising at least about 0.5%, by weight of the composition, of a first solvent selected
from the group consisting of water; water soluble organic solvents; organic solvents which are
strongly to moderately strong in hydrogen-bonding parameter; and mixtures thereof; wherein the
first solvent is other than C.sub.1 -C.sub.3 monohydric alcohol, C.sub.1 -C.sub.3 ketone and
C.sub.1 -C.sub.3 ether; wherein the silicone functional polymer is present in an amount effective to
stabilize the emulsion in the personal care composition.
Laser method for subsurface cutaneous treatment
A laser method for selective photocoagulation of subsurface skin (dermis) for the purpose of
increasing skin tone, reducing wrinkles, removing hair, removing tattoos or treating varicose veins
without damaging the skin surface (epidermis). A diffuser lens in the laser apparatus is employed to
focus the laser energy to the dermis. The laser apparatus includes a highly transmissive contact tip
and cooling means to reduce heat build-up in the contact tip, as monitored by a thermocouple
mechanism. The present invention can be used alone or in conjunction with superficial laser
resurfacing or chemical peels to increase skin tone.
Photoprotective/cosmetic compositions comprising 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5triazine and salicylate solvents therefor
solar radiation, comprise (i) a photoprotecting effective amount of 2,4,6-tris[p-((2'ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) at least one homomenthyl and/or octyl
salicylate solvent for the triazine sunscreen compound (i), in a cosmetically acceptable vehicle,
Personal cleansing compositions providing improved hair and skin conditioning
Photoprotective/cosmetic compositions comprising benzotriazole-substituted silicon compounds and
benzoic triacid triesters
least one solubilized organolipophilic silicon compound, whether silane or organopolysiloxane,
bearing a benzotriazole function substituent and (ii) an amount of at least one benzoic triacid
triester effective to (substantially) dissolve said at least one organolipophilic silicon compound.
Laser method for subsurface cutaneous treatment
A laser method for delivery of pulsed infrared laser energy to a predetermined depth below the
surface of the epidermis is disclosed. The method can be used to increase skin tone and reduce
wrinkles. For the purposes of increasing skin tone, a novel method for quantifying the effect in vivo
is disclosed. Post-treatment topical application of a pharmaceutical mixture including antiinflammatory, anti-oxidant and neocollagen promoting agents can be used to increase new collagen
synthesis stimulated by the present invention.
comprised thereof
Method for detecting cyanide in cutaneously transpired gas
A method of detecting cyanide concentration in the cutaneously transpired gas of a patient,
allowing for the timely implementation of an appropriate treatment. Where the skin of a patient
suffering from cyanide poisoning has been burnt, the present invention provides for a noninvasive
means of cyanide treatment. In practice, a material is impregnated with methemoglobin and
attached to a patient's skin. A barrier means located between the impregnated material and the
patient's skin allows for the transfer of cyanide gas from the patient into the material. However, this
barrier means does not allow for the transfer of the methemoglobin from the impregnated material
into the patient's skin. The material is monitored for photometric change, and, where a change
indicative of cyanide poinsoning is present, appropriate treatment is administered.
Stable oil-in-water emulsion, process for its manufacture and its use in the cosmetic and dermatological
fields
A fine and stable emulsion of an oily phase in an aqueous phase containing ionic polymer particles,
the oil globules of the emulsion having a mean size of at most 500 nm, a process for the
stabilization of fluid emulsions, a process for the preparation of these emulsions and their use in the
cosmetic and dermatological fields and more particularly as composition for anti-sun protection.
Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents
The present invention relates to specific adamantyl or adamantyl group derivative containing
retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are
useful for the treatment of many cancers and solid tumors, especially androgen-independent
prostate cancer, skin cancer, pancreatic carcinomas, colon cancer, melanoma, ovarian cancer, liver
cancer, small cell lung carcinoma, non-small cell lung carcinoma, cervical carcinoma, brain cancer,
bladder cancer, breast cancer, neuroblastoma/glioblastoma, and leukemia. Also, the invention
relates to novel adamantyl or adamantyl group derivative compounds which are useful as active
agents for the treatment or prevention of keratinization disorders and other dermatological
conditions, and other diseases.
Resorcinol derivatives
The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.
Particles of cross-linked proteins and polysaccharides with hydroxamic groups for chelating metals and
their uses notably in cosmetics
The invention relates to small sized particles. These particles comprise at least on the surface
thereof a wall composed of a mixture of at least one protein and at least one polysaccharide which
are cross-linked, preferably by interfacial cross-linking with a polyfunctional acylating agent which
forms at least amide and ester bonds, and optionally anhydride bonds with amine, hydroxyl or
carboxyl functions of the protein and of the polysaccharide, and which comprise hydroxamic
groups on the surface thereof for chelating metal ions. These particles can be used in cosmetics or
in pharmacy notably for the chelation or release of metal ions.
Air bag tear seam and method of manufacture
A method for manufacture an air bag cover includes providing a cover skin made of a polymeric
material and weakening a seam region in the skin by selective exposure to ultraviolet light.
Electrode with improved signal to noise ratio
An electrode assembly for sensing an electrochemical signal diffused from a source to a working
electrode which is comprised of a plurality of substantially separated working electrode surfaces is
disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a
plurality of working electrode surfaces or components and 2) a electrically insulating gap defined
by adjacent edges of 1) insulating the working electrode surfaces or components from each other.
The working electrode components are configured to receive electrochemical signal from two or
preferably three dimensions simultaneously. The working electrode components configured over
the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to
a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a
given period of time.
Photoprotective/cosmetic compositions comprising benzotriazole-substituted silicon sunscreens and
cinnamic/salicylic acid solubilizing agents therefor
least one solubilized organolipophilic silicon compound, whether solid silane or
organopolysiloxane, bearing a benzotriazole function substituent and (ii) an amount of at least one
cinnamic acid sunscreen compound and/or at least one salicylic acid sunscreen compound effective
to (substantially) dissolve said at least one organolipophilic silicon compound.
Clonidine preparations
Sympathetically maintained peripheral neuropathic pain syndromes are relieved by topically
applying, to the affected region of a patient suffering from such pain, a pain relieving amount of an
aqueous gel comprising clonidine, a water-gelling amount of a pharmaceutically acceptable gelling
agent and having a physiologically tolerable pH value. Pain relief was achieved with applied
amounts of clonidine in the range of about 2 milligrams per day to about 6 mg per day.
Triaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I):
##STR1## and are useful for the treatment of a wide variety of disease states, whether human or
veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and
Comb polymers for regulating cell surface interactions
Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and
Photoprotective/cosmetic compositions comprising camphorsulfonic acid and bisresorcinyltriazine
sunscreens
of (i) benzene-1,4-di(3-methylidene-10-camphorsulfonic acid, or partially or completely
neutralized form thereof, and (ii) at least one bisresorcinyltriazine compound, formulated into a
topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.
Detergent cosmetic compositions and use thereof comprising an aminosilicone and a cationic polymer
Novel detergent compositions comprising, in a cosmetically acceptable medium, (A) a washing
base comprising at least one ether sulphate anionic surfactant and at least one surfactant of
alkylbetaine type, and (B) a conditioning system comprising at least one cationic polymer,
preferably dimethyldiallylammonium, and at least one aminosilicone, and uses thereof.
Skin enhancement using laser light
Methods of applying laser light to the skin, and apparatus therefor, include methods for removing
hair, for bleaching hair, for transdermal drug delivery, for sensing a body function, for skin
tightening, and for imaging subsurface structures are described. The hair removal methods and the
hair bleaching methods include infiltrating a transparent fluid with an index of refraction greater
than that of skin tissue into hair ducts to help transmit the laser light down the hair ducts. The
transdermal drug delivery and body function sensing methods include exfoliating layers of the
stratum corneum from a section of skin with laser light. A transdermal drug delivery patch can be
placed over the exfoliated skin section, or an electrical sensor can be placed over the exfoliated skin
section. The skin tightening method includes implanting a light absorbing material in the dermis of
a section of skin and illuminating the skin section to disturb the dermis in such a way as to cause a
healing reaction that forms more collagen fibers. The imaging system includes a confocal
microscope that has been adapted to view only a time-gated portion of laser light reflected from the
skin.
Radiation and nanoparticles for enhancement of drug delivery in solid tumors
The present invention discloses a method/system utilizing interaction of electromagnetic pulses or
ultrasonic radiation with nano- and microparticles for enhancement of drug delivery in solid
tumors. The particles can be attached to antibodies directed against antigens in tumor vasculature
and selectively delivered to tumor blood vessel walls. Cavitation induced by ultrasonic waves or
local heating of the particles by pulsed electromagnetic radiation results in perforation of tumor
blood vessels, microconvection in the interstitium, and perforation of cancer cell membrane, and
therefore, provides enhanced delivery of macromolecular therapeutic agents from blood into cancer
cells with minimal thermal and mechanical damage to normal tissues.
Synergistically UV-photoprotecting triazine/silicone compositions
The invention relates to novel cosmetic and/or dermatological compositions, in particular for
photoprotecting the skin and/or the hair, characterized in that they comprise, in a cosmetically
acceptable support in particular of oil-in-water type, (i) as first screening agent, at least one specific
1,3,5-triazine derivative, and (ii) as second screening agent, a silicon derivative containing a
benzotriazole function, the said first and second screening agents being present in the said
compositions in an amount which is effective for producing synergistic activity with respect to the
sun protection factors imparted. Application to protecting the skin and the hair against the effects of
ultraviolet radiation.
Bioaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof
Photoprotective/cosmetic compositions comprising w/o/w stable triple emulsions
The present invention relates to a cosmetic or dermatological emulsion of the water/oil/water
(W/O/W) type, characterized in that it comprises: (a) an external aqueous phase and (b) a noncontinuous fatty phase constituting, with an internal aqueous phase, a water/oil (W/O) primary
emulsion, the said fatty phase comprising, as lipophilic emulsifier, at least one block copolymer
composed of a polymer block derived from a monohydroxycarboxylic acid and of a polymer block
derived from an alkylglycol or from a polyalkylene glycol; (c) at least one photoprotective system
capable of screening out UV (UV-A and/or UV-B) radiation. The invention also relates to its uses
in and for the manufacture of cosmetic or dermatological compositions for the photoprotection of
the skin or hair.
screening polymer
Apparatus and method for removing hair
An apparatus and method for removing hairs from a region of skin, the apparatus including: a
housing having an opening therein, the housing forming a cavity enclosing a volume of air when
the opening is placed in contact with the region of skin; a switchable heat source disposed within
the housing that rapidly heats the volume of air to a temperature sufficient to destroy the hair by
conduction of heat along the length of the hair to a follicle thereof; and a power source that
controllably energizes the heat source.
Pipe testing apparatus and method using electrical or electromagnetic pulses transmitted into the pipe
A method and system for detecting corrosion on a pipe or a pipeline. An electrical or
electromagnetic pulse is transmitted into a pipe or pipeline to travel as a propagating
electromagnetic wave along the pipeline to a receiving location. Both the distance traveled from the
transmitting and receiving location, and also the time interval for such travel are measured.
Velocity of the wave is detected as a means of ascertaining whether corrosion is present. Various
embodiments, using both multi-channel and single cables, are used to transmit the detected waves,
and the waves are received at a plurality of spaced locations along the length of the pipe or
pipeline. For an insulated pipeline, the signals can be received by a directional antenna, and the
pulses can be transmitted into the pipeline by means of either an antenna placed directly adjacent to
the pipeline or a magnet electrical contact member in direct contact with the pipeline.
Laser apparatus for subsurface cutaneous treatment
A laser apparatus for selective photocoagulation of subsurface skin (dermis) for the purpose of
increasing skin tone, reducing wrinkles, removing hair, removing tattoos or treating varicose veins
without damaging the skin surface (epidermis). A diffuser lens in the laser apparatus is employed to
focus the laser energy to the dermis. The laser apparatus includes a highly transmissive contact tip
and cooling means to reduce heat build-up in the contact tip, as monitored by a thermocouple
mechanism. The device can be used alone or in conjunction with superficial laser resurfacing or
chemical peels to increase skin tone.
Particles, especially microparticles or nanoparticles, of crosslinked monosaccharides and
oligosaccharides, processes for their preparation and cosmetic, pharmaceutical or food compositions in
which they are present
Particles comprising an outer wall formed of one or more saccharide components selected from the
group consisting of monosaccharides and oligosaccharides crosslinked by interfacial crosslinking in
emulsion, preferably at room temperature, with a polyfunctional acylating crosslinking agent to
produce ester linkages between the acylatable hydroxyl group(s) of the primary alcohol(s) of the
saccharide component and the acyl groups of the polyfunctional acylating agent. These particles
can be used for the manufacture of cosmetic, pharmaceutical and food compositions.
Photostabilized sunscreen compositions comprising dibenzoylmethane compounds
Composition for the cosmetic and/or pharmaceutical treatment of the upper layers of the epidermis by
topical application to the skin, and corresponding preparation process
Composition comprising biodegradable nanoparticles encapsulating oils which are active and/or
which contain an active ingredient having a cosmetic and/or pharmaceutical action in the upper
layers of the epidermis. The nanoparticles are preferably prepared from a polymer of (C.sub.2 C.sub.12) alkyl cyanoacrylate.
Powdered cosmetic and/or dermatological lotion and its use
A cosmetic and/or dermatological lotion comprising an aqueous phase and a powdered phase, the
powdered phase comprising at least one active powder and hollow particles based on at least one
acrylic or methacrylic polymer or copolymer, the aqueous phase being present in an amount
ranging from 90 to 99.99% by weight with respect to the total weight of the lotion. The inventive
lotion has the advantage of being soft on application and of exhibiting a powdered phase which
does not become clogged. The lotion may be used for caring for, cleaning, removing make-up from
and/or coloring the skin, mucous membranes and/or scalp.
Systems and methods for the multispectral imaging and characterization of skin tissue
Systems and methods for the multispectral imaging of skin tissue enables automatic
characterization of the condition of a region of interest of the skin, based on direct digital imaging
of the region of interest or the digitization of color photographic slides of the region of interest,
illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is
automatically segmented and that segmented mask is used to segment the other images by a digital
processor. Parameters related to the texture, asymmetry, blotchiness and border irregularities are
also automatically estimated. The region of interest is automatically characterized by the digital
processor, based on those parameters. The region of interest may include a skin lesion, in which
case the present invention enables the characterization of the lesion as malignant or benign.
Method of selective photothermolysis
A method and apparatus for selective photothermolysis of a target tissue within surrounding tissue.
The target and the surrounding tissue are heated to a predetermined temperature of about 60.degree.
C. by a pulsed heat source such as a flash lamp which creates a temperature gradient in the air
included in a cavity formed between the housing of the apparatus and the surrounding tissue. The
surface temperature of the tissue is monitored by a sensor unit. When the tissue surface reaches the
predetermined temperature the target tissue is heated to the point of coagulation, preferably by
narrow band electromagnetic radiation. The temperature difference between the coagulating target
and the surrounding tissue is sufficiently mild that heat diffusing out of the target does not damage
the surrounding tissue, even in the case of a relatively large target such as varicose veins. The
heating action may be terminated by automatically pumping air or another suitable coolant into the
cavity when the surface of the tissue reaches a preset value or by lifting the apparatus off the tissue.
The apparatus may include a programmable controller which may be programmed locally or
remotely with the treatment parameters.
Photoprotective/cosmetic compositions comprising camphorsulfonic acid, bisresorcinyltriazine and
of (a) benzene-1,4-bis(3-methylidene-10-camphorsulfonic acid), optionally in neutralized form
thereof, (b) at least one bisresorcinyltriazine compound, and (c) at least one compound containing
at least two benzoazolyl groups or at least one benzodiazolyl group, formulated into a topically
Photoprotective/cosmetic compositions comprising benzotriazole and benzoazolyl/benzodiazolyl
sunscreens
of (a) at least one benzotriazole compound, and (b) at least one compound containing at least two
benzoazolyl groups and/or at least one benzodiazolyl group, formulated into a topically applicable,
Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised
thereof
Novel liposoluble and photostable N-substituted benzimidazole/benzofuryl-benzazole siliconcontaining compounds are conspicuously excellent UV-absorbers and are conveniently formulated,
e.g., into topically applicable sunscreen/cosmetic compositions well suited for the UVphotoprotection of human skin and/or hair.
formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(d): ##STR2## and
are useful for the treatment of disorders and/or ailments manifesting an overregulation of PAR
Method of measuring physiological function
A method of measuring physiological function of a group of body cells, includes the step of
selecting a detectable agent capable of emitting a measurable electromagnetic emission. The agent
is introduced into body fluid wich contacts the group of body cells. The emission is measured, and
physiological function is determined based on measurement of the emission.
Method of depigmenting and/or bleaching skin and/or body hair or head hair
The use, in a topical cosmetic composition, or for the manufacture of a topical dermatological
composition, intended for depigmenting and/or bleaching human skin, body hair or head hair, of at
least one compound comprising a phenyloxime fragment.
Stable cosmetic composition comprising a poly (2-acrylamido-2-methylpropanesulphonic acid) polymer
uncoated solid particles and an oily dispersing polymer
The invention relates to a composition, in particular for cosmetic, dermatological, hygiene and/or
pharmaceutical use, comprising at least one crosslinked poly(2-acrylamido-2This document was prepared by www.FormulaScan.com. Its reproduction in any type of form or format is strictly prohibited without
methylpropanesulphonic acid) polymer neutralized to at least 90%, uncoated solid particles and an
oily dispersing polymer. It also relates to the cosmetic applications of such a composition.
Method of reducing sebum production by application of pulsed light
A method of reducing sebum production in human skin, used primarily for cosmetic purposes,
including the prevention of acne vulgaris, comprising the use of pulsed light having a wavelength,
if monochromatic, or a wavelength range, if produced by a filtered non-monochromatic source,
which targets the lipids contained within the sebaceous gland, thus destroying the differentiated and
mature sebocytes by photothermolysis without damage to the surrounding and overlying tissue or
to the basement membrane of the sebaceous gland.
Photoprotective/cosmetic compositions comprising bisresorcinyltriazine and benzoazolyl/benzodiazolyl
of (a) at least one bisresorcinyltriazine compound, and (b) at least one compound containing two
benzoazolyl groups, or at least one benzodiazolyl group, formulated into a topically applicable,
Photoprotective/cosmetic compositions comprising benzotriazole, bisresorcinyltriazine and
particularly solar ratiation, comprise synergistically UV-photoprotecting effective amounts of each
of (a) at least one benzotriazole compound, (b) at least one bisresorcinyltriazine compound and (c)
at least one compound containing at least two benzoazolyl groups per molecule and/or at least one
compound containing, per molecule, at least one benzodiazolyl group, formulated into a topically
Cosmetic composition comprising pigments and an antiperspirant and use of such a composition
A composition, in particular a cosmetic composition, which can especially be in the form of an
emulsion, a gel or a vesicle dispersion, the said composition comprising a pulverulent phase in an
amount of less than or equal to 80% by weight relative to the total weight of the composition, this
composition comprising at least one pigment and at least one antiperspirant. Use of such a
composition in cosmetics, in particular for make-up, in order to improve the staying power of the
color of the composition.
A method of hair depilation using an Nd:YAG laser which causes local heating at the hair bulb due
to the absorption of the oxyhemoglobin contained in the capillaries. The Nd:YAG laser operates at
1060 nanometers. Each pulse is a special pulse having a first portion and a second portion, where
power output in the first portion is 20 times greater than power output in the second portion. That
way, the first portion of each pulse is used to quickly heat up the tissue to a damaging temperature,
and the second portion maintains that temperature to cause hair removal for the tissue.
Hair removal device and method
or the skin tissue feeding of the hair. Specific embodiments to produce death of the follicles or the
skin tissues feeding the hair by heating and by photochemical reaction.
Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological,
pharmaceutical, and/or ophthalmological fields
aqueous phase; and at least one anionic surfactant selected from the group including phosphoric
acid fatty esters and oxyethylenated derivatives thereof, and mixtures thereof; wherein the oily
phase includes oil globules having a number-average size of less than 100 nm; wherein the oily
phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight
ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process
for making the nanoemulsion, and methods for its use. The nanoemulsion is ideally transparent and
stable on storage. It can ideally contain large amounts of oil while retaining good transparency and
good cosmetic properties. The nanoemulsion is particularly useful in compositions, including
topical, pharmaceutical, dermatological, cosmetic, opthalmic, and opthalmologic. The composition
is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.
Depilation
Mammalian hair is depilated using a laser source capable of emitting pulse radiation, each pulse
having a duration of 1 microsecond to 1 millisecond, and having a wavelength in the range of 600
to 1500 nanometers. The radiation exposure dose is preferably between 2 and 25 J/cm.sup.2. A
selected area of a subject's skin is irradiated by the pulsed radiation, the area having a plurality of
irradiation zones. The laser source is successively pulsed so as to irradiate successive zones of the
treatment area with the radiation, so as to destroy subdermal biological material associated with
hair growth.
Cosmetic composition useful notably for the skin whitening and melanogenesis inhibiting agent
containing such a cosmetic composition
Cosmetic composition useful notably in the whitening of skin which it includes, in association with
any suitable excipient, at least one compound of the following general formula (I): ##STR1##
wherein: R.sub.1 represents a hydrogen atom, a linear or branched alkyl group or a thiazoline
group, R.sub.2 represents a hydrogen atom, a linear or branched alkyl group or a linear or branched
alkyl group substituted by a carboxyl, a hydroxyl, an amine or a thiol group, R.sub.3 represents a
hydrogen atom, a linear or branched alkyl group, an arylalkyl group, an acyl group or an acyloxy
group, R.sub.4 represents a hydrogen atom or a linear or branched alkyl group, R.sub.5 represents a
hydrogen atom, a hydroxyl group or a linear or branched alkyl group.
Method of treating wounds with ultraviolet C radiation
A method of treating wounds includes the step of applying UVC radiation to the wound for a time
and at a proximity and intensity sufficient to have a bacteriocidal effect. The method is particularly
effective when carried out with a UVC lamp having an intensity of between 5 and 20
.mu.W/cm.sup.2, with a duration of between about 5 seconds and 1 minute and a proximity to the
wound of between about 1/4 and 3 inches from the wound being preferred. It has been observed
that such application of UVC radiation can kill up to 100 percent of the microorganisms present in
a wound, thereby enabling the wound to heal free of infection.
Composition especially in the form of emulsion, gel or aqueous solution, including a crosslinked poly (2acrylamido-2-methylpropanesulphonic acid) polymer neutralized to at least 90%
Photoprotective/cosmetic compositions comprising bis-hydroxyphenylbenzotriazole and
benzazolyl/benzodiazolyl sunscreens
Topically applicable sunscreen/cosmetic compositions well suited for the SPF synergistically
enhanced photoprotection of human skin and/or hair against the damaging effects of UVirradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective
amounts of each of (a) at least one bis-hydroxyphenylbenzotriazole sunscreen compound and (b) at
least one second sunscreen compound which comprises at least two benzazolyl functional groups
per molecule and/or at least one sunscreen compound which comprises at least one benzodiazolyl
functional group per molecule, formulated into a topically applicable, cosmetically acceptable
vehicle, diluent or carrier therefor, advantageously formulated as an oil-in-water emulsion.
Apparatus and methods for removing blood vessels
Methods and apparatus for inducing necrosis and degradation of blood vessels are described. The
invention is suitable to treat various conditions such as varicose veins and telangiectasia. The
apparatus for inducing degradation of a blood vessel in a tissue, e.g., skin, includes an external
energy source that non-invasively delivers to the blood vessel energy that is preferentially absorbed
by the blood vessel to heat the blood vessel walls to a temperature of at least about 60 degrees
centigrade, and a pressure source connected to the energy source to collapse the blood vessel once
the blood vessel walls have been heated to at least about 60 degrees centigrade for a period of time
and with a force sufficient to permanently weld the apposed walls of the blood vessel together,
whereby the blood vessel undergoes necrosis and degradation.
Photostabilized sunscreen compositions comprising dibenzoylmethane compounds and
benzylidenecamphor-substituted silanes/organosiloxanes
Use of nanoscale sterols and sterol esters
A composition containing an effective amount of nanoparticles selected from the group consisting
of nanoscale sterols, nanoscale sterol esters, and mixtures thereof.
Method and apparatus for therapeutic treatment of skin
A method and apparatus of reducing skin wrinkles, including applying an acoustic pulse or train of
pulses to a subsurface region of human skin without damaging or adversely affecting the surface or
epidermis layer of the skin. The pulses cause changes in the dermis layer of the skin that result in
enhanced smoothness of the epidermis layer of the skin. In particular, the acoustic pulses are
applied to the dermis layer at an amplitude and for a period of time sufficient to induce production
of new connective tissue that reduces or eliminate of skin wrinkles.
Use of an indigoid compound in a cosmetic composition, in particular a make-up composition, in order to
confer on it antimicrobial properties and the property of lengthy hold over time
The invention relates to the use of at least one compound of formula: ##STR1## in which R.sub.1
and R'.sub.1 are C.sub.1 -C.sub.18 alkyl radicals which are optionally substituted by one or more
halogens or hydroxyls and/or are interrupted by one or more heteroatoms, and R.sub.2 to R.sub.5
and R'.sub.2 to R'.sub.5 are hydrogen or halogen atoms, hydroxyl radicals or C.sub.1 -C.sub.6
alkyl, alkyloxy, acyl or acyloxy radicals, in a cosmetic composition, in particular a make-up
composition, in order to confer on it antimicrobial properties and properties of lengthy hold over
time and/or of non-migration and/or of freedom from transfer and/or of non-formation of streaks.
The invention also relates to a cosmetic composition, in particular a make-up composition and
especially an eyeshadow, comprising such a compound in a silicone binder.
Nanoemulsion based on oxyethylenated or non-oxyethylenated sorbitan fatty esters, and its uses in the
The present invention relates to a nanoemulsion, the oil globules of which have an average size of
less than 100 nm, comprising (1) a surfactant which is solid at a temperature of less than or equal to
45.degree. C., which surfactant is chosen from sorbitan fatty esters and oxyethylenated sorbitan
fatty esters, (2) at least one oil having a molecular weight of greater than 400 and (3) at least one
ionic amphiphilic lipid chosen from the group formed by the alkaline salts of dicetyl and dimyristyl
phosphate, the alkaline salts of cholesterol sulphate, the alkaline salts of cholesterol phosphate,
lipoamino acids, the sodium salts of phosphatidic acid, cationic amphiphilic lipids and alkylsulfonic
derivatives, the ratio by weight of the amount of oily phase to the amount of surfactant ranging
from 2 to 10. The surfactant used is, for example, chosen from sorbitan monostearate, sorbitan
monopalmitate and sorbitan 20 EO tristearate. The emulsion obtained is transparent and stable on
storage. It can comprise large amounts of oil while retaining good transparency and while having
good cosmetic properties. The invention also relates to the use of the nanoemulsion according to
the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin
Polymer glucan ether derivatives, their manufacturing as well as their use
A method for treatment of skin includes topical application of a composition containing a
therapeutically effective amount of a 1,3-beta-glucan ether derivative. Such application effectively
provides treatment and/or prophylaxis of various skin-related problems, such as neurodermatitis
and psoriasis, and reduces the evidence of aging by minimizing wrinkles. In an advantageous
embodiment, the glucan ether derivative is present in the composition in a range of concentration of
about 0.002% to about 8% by weight. In another embodiment the glucan ether derivative is
advantageously carboxymethyl glucan sodium salt.
Oil-in-water emulsions containing a 1,3,5-triazine derivative and a copolyol silicone and cosmetic
applications
The present application relates to novel oil-in-water emulsions comprising i) at least one specific
1,3,5-triazine derivative and ii) at least one polyalkyl-polyethersiloxane carrying polyoxyalkylene
groups grafted onto the main silicone chain; with the proviso that the said emulsions do not
comprise cetylstearyltrimethylammonium chloride. Another subject-matter of the present invention
is the use of such emulsions in the manufacture of cosmetic or dermatological compositions
intended for the photoprotection of the skin and/or hair and/or other keratinous substances against
ultraviolet radiation, in particular solar radiation.
Combination of a retinoid with a polyamine polymer
A composition comprising the combination of at least one retinoid selected from the group
consisting of vitamin A (retinol) and the bioconvertible precursors of vitamin A and at least one
polyamine polymer.
Combination of a retinoid with a histidine derivative
A composition containing at least one retinoid and at least one histidine derivative. The histidine
derivative improves the stability of the retinoid in the composition. The composition may be used
to treat skin and/or hair.
Photon irradiation human pain treatment monitored by thermal imaging
Photo illumination of sites along a nerve supplying a painful region is conducted one at a time until
a thermal image of that region or one related to it shows a significant change in temperature, at
which time the treatment is terminated. If it is an extremity (hand or foot) that is has pain
symptoms, one extremity is treated by exposing its nerve sites to photo illumination while the other
extremity is observed by a thermograph instrument. Use of the thermal image as a feedback
technique allows the treatment to be terminated as soon as the favorable temperature change takes
place.
Nanoscale organic UV filters
A cosmetic or pharmaceutical composition used for blocking the penetration of ultraviolet
radiation, the composition containing nanoscale organic UV filters having a mean diameter of from
10 to 300 nm.
Blue tinted automobile lamp capsule
The invention involves application of a luster coating to the exterior of a glass lamp capsule
envelope to obtain a blue coloration of the transmitted light. The result is a higher color
temperature light source that is commercially preferred. The preferred blue luster is formed from a
coating solution containing organometallic components and solvent, that is heat treated in an
oxidizing atmosphere to form a gold containing bismuth-titanium oxide material. The filament is
adjusted to yield the overall necessary number of lumens. The blue luster tinted automobile lamp
capsule is a durable, and yields the proper number of lumens with little or no increase in glare. The
blue luster tinted lamp capsule is therefore compliant with legal standards.
Synthetic peptides and their use in cosmetic or dermopharmaceutical compositions
The invention concerns the use of peptides of general formula R1-L-Tyr-L-Arg-R2 in which R1=H
or a R3-C=0 with R3=a C1 to C20 alkyl chain, linear or branched, saturated or unsaturate,
hydroxylated or not, or with R3=an aryl, aryl-alkyl or alkyloxy or aryloxy or arylalkyloxy group,
and in which R2=OH or a O-R4 group with R4=a C1 to C20 alkyl chain, or R2=a NH2, NHX or
NXX group with X=a C1 to C4 alkyl chain. The peptides have a soothing effect on the skin,
including by topical application, and attenuates the effects of benign skin sores (after shave
irritation, sunstroke, frostbite, chaps, depilation). They are used in acceptable cosmetic excipients
and in effective in vivo concentrations.
Photoprotective cosmetic composition containing an anionic surfactant, compounds for screening out
ultraviolet radiation and a cationic or zwitterionic amphiphilic compound, and use thereof
The invention relates to a cosmetic composition, in particular for photoprotecting the skin and/or
the hair, in the form of a dispersion comprising two immiscible phases stabilized with at least one
anionic surfactant chosen from the salts of fatty acids and of monovalent or polyvalent metals, of
ammonium or of organic bases, a compound for screening out ultraviolet radiation, which can be
adsorbed at the interface of the said immiscible phases, derived from benzylidenecamphor and
comprising at least one partially or totally neutralized sulphonic acid function, a metal oxide
nanopigment coated with hydrophobic hydrocarbon-based coating agents and a cationic or
zwitterionic amphiphilic compound which leads, with the anionic surfactant, to the formation of a
compound capable of lowering the water/liquid paraffin interface tension at 40.degree. C. by more
than 14 mN.m.sup.-1 for an anionic surfactant concentration of 0.1 mmol/100 g, by more than 26
mN.m.sup.-1 for an anionic surfactant concentration of 0.5 mmol/100 g and by more than 33
mN.m.sup.-1 for an anionic surfactant concentration of 1 mmol/100 g.
Nanoemulsion based on ethoxylated fatty ethers or on ethoxylated fatty esters and its uses in the
aqueous phase; and at least one surfactant that is solid at a temperature of less than or equal to
45.degree. C. and which is selected from the group including ethoxylated fatty ethers and
ethoxylated fatty esters, and mixtures thereof; wherein the oily phase includes oil globules having a
number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a
ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and
methods for its use. The emulsion is ideally transparent and stable on storage. It can ideally contain
nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, cosmetic,
opthalmic, ophthalmologic. The composition is also particularly useful in applications to the skin,
hair, scalp, mucous membranes, and eyes.
Photoprotective/cosmetic compositions comprising novel benz-x-azole-substituted silane/siloxane
sunscreens
Photoprotective, topically applicable sunscreen/cosmetic compositions well suited for the UVphotoprotection of human skin and/or hair, comprise an effective UV-photoprotecting amount of at
least one novel benz-x-azole-substituted silane or siloxane having the formula (1) or (2): ##STR1##
A--SiR'.sub.1 R'.sub.2 R'.sub.3 (2) in which A is a radical having the structural formula (I):
##STR2##
Photoprotective/cosmetic compositions comprising aminoamidine sunscreens
Topically applicable sunscreen/cosmetic compositions well suited for the photoprotection of human
skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation,
comprise an effective UV-photoprotecting amount of at least one characteristically novel
aminoamidine compound, advantageously having the structural formula (I): ##STR1## formulated
into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.
Luminescent in vivo glucose measurement
A luminescent in vivo glucose measurement method and apparatus is provided. The luminescent in
vivo glucose measurement method includes the steps of illuminating displaced luminescent
molecules with illuminating light, the displaced luminescent molecules and associated captive
glucose analogue molecules being contained within an implanted luminescent in vivo measurement
apparatus implanted within the interstitial fluid of the subject, and measuring an emitted light, the
emitted light being emitted in response to the illumination, wherein the emitted light is related to
the glucose level in the interstitial fluid.
Immobilization of vitamin A acid by cationic polyelectrolytes
Mesomorphic complexes of vitamin A acid and cationic polyelectrolytes, their preparation and use.
The cationic polyelectrolyte, for example PDADMAC, PM4VP, poly (ionene-6,3),
polyethyleneimine or a poly-L-amino acid, is mixed with vitamin A acid to produce mesomorphic
complexes. Uses of these mesomorphic complexes include the transport of vitamin A in the human
body, the treatment of severe cases of acne externally, courses of skin rejuvenation, and the
inhibition of malignant tumors.
Anhydrous hydrophobic cosmetic composition in the form of a compact powder
An anhydrous hydrophobic cosmetic composition in the form of a compact powder which can be
taken up in dry form or with water, comprising a particulate phase comprising hydrophilic
pulverulent compounds, wherein the hydrophilic pulverulent compounds represent 20 to 35% by
weight relative to the total weight of the particulate phase. The invention also relates to a make-up
process using such a composition, as well as to a device comprising such a composition and a
sponge which can be moistened.
Comb copolymers for regulating cell-surface interactions
UV-photoprotecting W/O emulsions comprising micronized insoluble screening agents & nonscreening
oxyalkylenated silicones
Topically applicable, water-resistant cosmetic/dermatological water-in-oil (W/O) emulsions well
suited for the UV-photoprotection of human skin and/or hair comprise (a) at least one aqueous
phase and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one
micronized particles ranging from 0.01 to 2 .mu.m, and (d) at least one oxyalkylenated non-UVscreening organomodified silicone.
Utilization of an extract of a plant of the Cecropia genus
The utilization of at least one extract of a plant belonging to the cecropia genus as an active agent.
The extract is used alone or in conjunction with at least one other active agent for preparing a
cosmetic or dermopharmaceutical product or a cosmetic or dermopharmaceutical composition for
external local application on the skin, the mucous membranes and/or the epithelial or body
appendage formations.
Active topical skin protectants using reactive nanoparticles
A topical skin protectant formulation containing a barrier cream and an active moiety for protecting
warfighters and civilians against all types of harmful chemicals, specifically chemical warfare
agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that
serves to neutralize chemical warfare agents into less toxic agents.
Cosmetic composition comprising a compound such as indigoid
A cosmetic composition comprising, in a cosmetically acceptable medium, at least one compound
of formula (I) ##STR1## in which R.sub.1, and R'.sub.1 are chosen from alkyl radicals and
R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, and R'.sub.5 are chosen from a
hydrogen atom, a halogenated radical, a hydroxyl radical, an alkyl, alkyloxy, acyl, or acyloxy
radical having 1 to 6 carbon atoms. The use of compounds of formula (I) for coating substrate
particles, the resulting powder substance, and its use in a cosmetic composition.
UV-photoprotecting emulsions comprising micronized insoluble screening agents and associative
polymers
Topically applicable, water-resistant cosmetic/dermatological emulsions well suited for the UVphotoprotection of human skin and/or hair contain an effective UV-photoprotecting amount of at
least one micronized organic UV-screening agent insoluble therein, the mean particle size of such
micronized particles ranging from 0.01 to 2 .mu.m, and further containing at least one associative
polymer which is characteristically other than a C.sub.8 -C.sub.16 alkyl polyglucoside.
Synergistically UV-photoprotecting benzotriazole-substituted silicon/cinnamic acid compositions
Topically applicable cosmetic/dermatological compositions suited for improvedly UVphotoprotecting human skin and/or hair against the deleterious effects of ultraviolet irradiation,
advantageously oil-in-water emulsions, contain SPF-synergistically enhancing amounts of (a) at
least one UV-screening benzotriazole-substituted silicon compound and (b) at least one UVscreening cinnamic acid derivative, formulated into (c) a topically applicable,
Active topical skin protectants using combinations of reactive nanoparticles and polyoxometalates or
metal salts
A topical skin protectant formulation containing a barrier cream and a active moiety for protecting
warfighters and civilians against all types of harmful chemicals, specifically chemical warfare
agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that
serves to neutralize chemical warfare agents into less toxic agents.
Nanoemulsion based on alkyl ether citrates and its uses in the cosmetics, dermatological, pharmacological
and/or ophthalmological fields
A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising an
anionic surfactant chosen from alkyl ether citrates and at least one oil having a molecular weight of
greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant
ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise
large amounts of oil while retaining good transparency and while having good cosmetic properties.
It can constitute a composition for topical use, a pharmaceutical composition or an
ophthalmological composition. The invention also relates to the use of the nanoemulsion according
to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin
Emulsifier-free UV-photoprotecting emulsions comprising micronized insoluble screening agents
Topically applicable, water-resistant but emulsifier-free cosmetic/dermatological emulsions well
suited for the UV-photoprotection of human skin and/or hair contain (a) at least one aqueous phase
and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one
micronized particles ranging from 0.01 to 2 .mu.m and (d) optionally, at least one crosslinked
polymer of at least one ethylenically unsaturated monomer.
Nanoemulsion based on mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of a
glycerol and its uses in the cosmetics, dermatological and/or ophthalmological fields
A nanoemulsion, the oil globules of which have a number-average size of less than 100 nm,
comprising a surfactant chosen from mixed esters of a fatty acid or of a fatty alcohol, of a
carboxylic acid and of glycerol and at least one oil having a molecular weight of greater than 400,
the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10.
The nanoemulsion may be used in, for example, the cosmetics and dermatological fields, in
particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and
in the ophthalmological field, as an eye lotion for treating the eyes.
Opto-electronic ultra-violet radiation dosimeter
A dosimeter 10, which may be easily implemented as a monolithic device, using all-silicon
semiconductor fabrication techniques. The dosimeter 10 has a UV filter 11a, whose transmission
characteristics match those of the erythema action curve. The filtered radiation is detected by a
photodiode, and appropriate signal processing is performed to provide some sort of output
indicating UV dosage. Other embodiments use a UV sensitive photodiode without a filter.
Electromagnetic and laser treatment and cooling device
An apparatus for lowering the temperature of skin on a patient during treatment applying
electromagnetic energy to the skin comprising a window of a first thermally conductive material
through which electromagnetic energy can pass for placement against the epidermis of the skin. A
reservoir of coolant is spaced from an edge of the window. A non-flowing second thermally
conductive material connects the window and the reservoir to transfer heat from the window to the
coolant in the reservoir.
Method for vacuum pressure forming reinforced plastic articles
A method for thermoforming a reinforced article, comprising: providing a reinforced plastic sheet
comprising at least one thermoplastic material and reinforcement nanoparticles dispersed within the
at least one thermoplastic material, the reinforcement particles comprising less than 15% of a total
volume of the plastic sheet, at least 50% of the reinforcement particles having a thickness of less
than about 20 layers, and at least 99% of the reinforcement particles having a thickness of less than
about 30 layers; preheating said plastic sheet; communicating said preheated plastic sheet to a first
mold assembly having a first mold cavity defined by mold surfaces, the mold surfaces
corresponding to a configuration of the article to be molded, an amount of the plastic sheet
communicated to the first mold assembly being sufficient to form a skin of the article; applying a
vacuum to one side of the first mold assembly while concurrently applying pressurized gas to an
opposing side of the first mold assembly so as to force said heated plastic sheet into conformity
with the mold surfaces; cooling the conformed plastic sheet; transferring the conformed plastic
sheet to a second mold assembly; introducing to the conformed plastic sheet a reinforced plastic
melt made from material identical or different from that of the plastic sheet, said plastic melt
having a blowing agent to achieve volume expansion and the production of a cellular reticulate
structure; cooling said plastic melt to form a solidified plastic member adhered to said conformed
plastic sheet, said conformed plastic sheet and said adhered solidified plastic member together
comprising said article; and removing said article from said second mold assembly.
Nanoemulsion based on alkoxylated alkenyl succinates or alkoxylated alkenyl succinates of glucose and
its uses in the cosmetics, dermatological, opthalmological and/or pharmaceutical fields
A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a
surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of
glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a
molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount
of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It
can comprise large amounts of oil while retaining good transparency and while having good
cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition
or an ophthalmological composition.
Nanoemulsion based on ethylene oxide and propylene oxide block copolymers and its uses in the
A nanoemulsion comprising an oily phase dispersed in an aqueous phase and having oil globules
with a number-average size of less than 100 mm, which dispersion is facilitated by a surfactant
comprised of polyethylene oxide and polypropylene oxide blocks, the oily phase comprising at
least one oil having a molecular weight of greater than 400 and wherein the ratio by weight of the
amount of oily phase to the amount of surfactant ranges from 2 to 10.
Compositions comprising at least one UV screening agent and at least one flavylium salt which is
unsubstituted in position 3, for coloring the skin, and uses thereof
A cosmetic and/or dermatological composition intended for artificially coloring the skin, which
comprises, in, for example, a cosmetically acceptable support, at least one compound capable of
screening out ultraviolet radiation and at least one flavylium salt compound which is unsubstituted
in position 3, and which is substituted with at least one radical chosen from hydroxyl and alkoxy
radicals, wherein the at least one flavylium salt compound may be obtained, for example, in a
manner chosen from synthetically, from a plant extract containing it, and from an enriched plant
extract containing it. The invention also relates to the uses of these compositions for coloring the
skin.
Optical volume sensor
An optical sensor for measuring the volume of an object, the object having a top and a side. The
optical sensor comprises a source of light and a light sensor adapted to measure the amount of light
reflected off the side and off the top of the object, wherein the measured amount of the light
reflected off the side and the top of the object correlates to a height and a diameter of the object. At
least one optical device is adapted to direct light reflected off the side of the object to the light
sensor, and at least one optical device is adapted to direct light reflected off the top of the object to
the light sensor.
Use in cosmetic compositions of amphoteric surface-active agents for precipitating cationic polymers in
the diluted state
Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of
the SOD in cosmetic, food and pharmaceutical compositions
The invention relates to a novel purified isozyme of an autoclavable superoxide dismutase
extracted from the plant Potentilla atrosanguinea Lodd. Var. orgyrophylla, said isozyme having the
following characteristics, O.sub.2.sup.- scavenging activity remains same before and after
autoclaving; scavenges O.sub.2.sup.- from sub-zero temperature of -20.degree. C. to high
temperature of +80.degree. C.; O.sub.2.sup.- scavenging activity at 25.degree. C. for 30 days
without adding any stabilizing agent such as polyols or sugars; O.sub.2.sup.- scavenging activity in
the presence of saline (0.9% sodium chloride) to 61.8% of the control (without 0.9% sodium
chloride), stable at 4.degree. C. for at least 8 months; contamination free and infection free from
any living micro- and/or macro-organism after autoclaving; possesses temperature optima at
0.degree. C.; possesses a molecular weight of 33 kD under non-denaturating conditions; possesses a
molecular weight of 36 kD under denaturating conditions; has clear peaks in UV range at 268 and
275 nm; has an enzyme turnover number of 19.53.times.10.sup.4 % per nmol per min at 0.degree.
C.; and requires Cu/Zn as a co-factor, method for the preparation of the purified isozyme of
autoclavable superoxide dismutase and formulations containing the said autoclavable superoxide
dismutase.
Cosmetic composition containing a steroid and a 2-alkylalkanol or an ester thereof
A composition including at least one steroid chosen from DHEA and/or a biological precursor
and/or a chemical or metabolic derivative of the latter, characterized in that it additionally
comprises at least one 2-alkylalkanol comprising from 12 to 36 carbon atoms or an ester of such an
alcohol. The invention also relates to the cosmetic and dermatological uses of this composition, in
particular for preventing or treating chronological or actinic ageing and canities.
Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery
system
A semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic
delivery system for therapeutic applications is provided which includes a biocompatible semisolid
delivery system and a biocompatible combination semisolid, multiparticulate delivery system for
injection, deposition, or implantation within the body to facilitate local or systemic therapeutic
effects through the actions of incorporated medicaments or actions inherit to the system.
Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase-2
The present invention comprises a group of related lipid molecules, and methods for their use, that
maybe used to treat inflammation and certain inflammation related diseases. The group of related
lipid molecules are capable of inhibiting certain enzyme systems including phospholipase A.sub.2,
and cyclooxygenase-2. The group of related lipid molecules of the invention may be characterized
by specific structural characteristics, or by specific biological activity, including inhibition of the
previously listed enzymes.
Compositions which contain at least one cationic polymer and at least one active molecule contained in at
least one micro or nonopartculate vector, and their use for treating living or inert surfaces
The present invention relates to compositions which contain at least one cationic polymer and at
least one active molecule contained in at least one micro or nanoparticulate vector, and their use for
treating living or inert surfaces.
Non-invasive tissue glucose level monitoring
Instruments and methods for performing non-invasive measurements of analyte concentrations and
for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.
Use of a RAR-.gamma.-specific agonist ligand for increasing the rate of apoptosis
Methods of cosmetically or therapeutically treating diseases or disorders in cell populations whose
pathology is linked to an inadequate rate of apoptosis by administering a therapeutically effective
amount of 6-3-(1-adamantyl)-4-hydroxyphenyl)-2-naphthanoic acid.
Solubilization of 1,3,5-triazine derivatives with N-acyl amino acid esters
A composition comprising at least one 1,3,5-triazine derivative and at least one N-acyl amino acid
ester and its use in or for the manufacture of compositions, especially cosmetic and dermatological
compositions for protecting the skin and/or the lips and/or integuments against ultraviolet radiation,
in particular solar radiation. In addition, a cosmetic treatment process comprising the application of
the cosmetic composition, and the use of the at least one N-acyl amino acid ester, in anti-sun
compositions containing a 1,3,5-triazine derivative to improve the sun protection factor of the
composition.
(poly)thiaalkynoic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural
formula (I): and are useful for the treatment of a wide variety of disease states, whether human or
veterinary, for example inflammation disorders, as well as for the treatment of mammalian skin and
hair conditions/disorders.
Use of plant extracts with an anti-radical-type action
epithel or appendage structures.
Cosmetic composition in the form of a powder comprising a specific ester
The present invention relates to a cosmetic composition in the form of a powder containing a
particulate phase and a fatty phase, characterized in that the fatty phase contains at least one fatty
acid ester or at least one fatty alcohol ester, the carbonaceous chain of the fatty acid or alcohol
being branched and saturated, and containing 24 to 28 carbon atoms. It also relates to the cosmetic
applications of such a composition.
Skin care composition
There are provided compositions which include a retinoid and preferably retinol; an acid; and an
acid neutralizing effective amount of ammonium hydroxide. There are also provided compositions
which include a retinoid and a neutralized ammonium salt of an acid. Further provided are methods
for reducing fine lines and wrinkles and for increasing the clarity of a skin surface, cellular
turnover, skin radiance, skin smoothness, skin permeation or collagen synthesis in a mammal in
need thereof. Compositions as described above are administered topically to the skin of the animal.
Cyclodextrins preferentially substituted on their primary face by acid or amine functions
Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function
(CH.sub.2 OH) is substituted, the --OH portion being replaced by a substituent with formula --O-CO--R or --NR.sub.1 R.sub.2, where: R, R.sub.1 and R.sub.2 independently represent a linear or
cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30
carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22
carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in
particular to encourage tissue penetration, in a cosmetic application, or for the production of
pharmaceutical compositions, in particular dermopharmaceuticals.
Aqueous dispersion of water-insoluble organic UV filter substances
The invention relates to aqueous dispersions of sparingly water-soluble or water-insoluble organic
UV filter substances, which comprise at least one sparingly water-soluble or water-insoluble
organic UV filter substance as colloidally disperse phase in amorphous or partially amorphous
form.
Method and apparatus for the treatment of blood borne pathogens such as immunodeficiency virus
A method and apparatus for destroying blood borne pathogens is disclosed which utilizes a low
intensity direct current to generate positive particles from various metals which destroy viral
pathogens. A first electrode comprised of a metal such as silver is inserted into a patient's venous
system. Then, a second electrode is placed on the patient's exterior in the vicinity of the first
electrode. A low intensity direct current is applied to the first metal electrode which releases silver
cations to be bonded to the virus, resulting in the denaturing of the virus. The first electrode is
placed in the venous system of the infected patient via a catheter.
Light imaging contrast agents
The present invention relates to the use of particulate materials as contrast agents in in vivo light
imaging.
Nanoemulsion based on glycerol fatty esters, and its uses in the cosmetics, dermatological and/or
aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less
than or equal to 45.degree. C.; wherein the oily phase includes oil globules having a numberaverage size of less than 100 nm; wherein the oily phase includes at least one oil having a
ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and
methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain
nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for
moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the
ophthalmological field, as an eye lotion for treating the eyes.
of laser light having a wavelength which targets the keratin components of hair, thus destroying the
hair by photothermolysis without damage to surrounding skin or tissue; this primary method may
be supplemented by the use of intrafollicular hair removal methods utilizing a second wavelength
of light produced by the same source used to generate the primary light wavelength.
Topical compositions and methods of application
There are topical emulsion compositions having a cosmetic drug or medicinal active, a novel
compound of the present invention, and a vehicle. The novel compound is represented by a formula
selected from the group consisting of L--A--H and A--L--H, wherein L is a lipophilic moiety, A is
an aromatic moiety, and H is a hydrophilic moiety. Also provided are methods of emulsifying a
composition; improving the photostability of a composition; and enhancing the effectiveness of a
sunscreen composition.
Comixture of dextran sulfate/escin for treating skin redness/edema and/or sensitive skin
Comixtures of escin and dextran sulfate are effective for treating skin redness/edema and/or
sensitive skin, particularly redness and/or edema around the eyes and most particularly bags and/or
dark rings around the eyes.
Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one polyethylene
glycol (PEG) ester, and uses thereof
Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and
comprising at least one oil, at least one amphiphilc lipid, and at least one polyethylene glycol
(PEG) derivative chosen from PEG esters and PEG ethers chosen from compounds of formula (I):
in which: R.sub.1 is chosen from linear and branched, saturated and unsaturated alkyl groups
comprising from 8 to 30 carbon atoms and linear and branched, saturated and unsaturated acyl
groups comprising from 8 to 30 carbon atoms, R.sub.2 is chosen from a hydrogen atom, linear and
branched, saturated and unsaturated alkyl groups comprising from 1 to 30 carbon atoms, and linear
and branched, saturated and unsaturated acyl groups comprising from 1 to 30 carbon atoms, and n
is a number ranging from 80 to 350. Processes comprising such oil-in-water nanoemulsions.
Fluorescence detection assembly for determination of significant vegetation parameters
A basic assembly configuration for determination of relevant vegetation parameters includes a high
repetitive pulsed excitation laser (1) for the stimulation of chlorophyll fluorescence, a fluorescence
detector (3) including an imaging and separation optic (4, 5), a trigger and delay electronic (6) to
adjust the laser and appropriate detector timing and a detector electronic (7), consisting of a signal
recording and processing module. The assembly can be used for determination of relevant
vegetation parameters for agricultural, horticultural and greenhouse application.
Cosmetic or dermopharmaceutical composition in the form of beads and methods for preparing same
The invention concerns an anhydrous solid composition comprising at least a hydrophobic wax, an
oil and talcum, having preferably the form of beads with size ranging from 1 to 10000 microns. The
beads can contain a cosmetic or pharmaceutical active principle, pigments or an agri-food
constituent. The invention also concerns the method for preparing said beads.
Flat magnetic core
A toroidal tape core is produced from magnetic sheets (1) which may have slits (4). In order to
improve the behavior of the toroidal cores (3) at high frequencies, the magnetic sheets (1) have a
high surface roughness. The surface roughness of each magnetic sheet (1) is at least equal to the
skin penetration depth at the frequency being used.
Method for synthesis of hydroxyapatite, and hydroxyapatite complex and method for preparing the same
The present invention provides a method of synthesizing hydroxy apatite comprising the steps of
preparing a mixed material slurry by dispersing calcium hydroxide (Ca(OH).sub.2) powder into a
phosphoric acid (H.sub.3 PO.sub.4) solution; conducting a mechanochemical milling treatment in
which shearing force and compressive force based on a centrifugal force of a mechanical rotating
body are imparted to the mixed material slurry, and reacting the calcium hydrate component with
the phosphoric acid component under normal temperature and pressure thereby to prepare hydroxy
apatite (HAp) powder having fine crystals. According to the structure described above, there can be
provided a method of synthesizing hydroxy apatite having fine and uniform particle size which can
be directly synthesized under normal temperature and pressure in a short time through simple and
single process.
Multi-channel RF cable trap for magnetic resonance apparatus
A multi-channel RF cable trap (70) blocks stray RF current from flowing on shield conductors
(114) of coaxial RF cables (60) of a magnetic resonance apparatus. An inductor (116) is formed by
a curved semi-rigid trough (80) constructed of an insulating material coated with an electrically
conducting layer. Preferably, the inductor (116) and the cable follow an "S"-shaped path to
facilitate good electromagnetic coupling therebetween. The RF cables (60) are laid in the trough
(80) and the shield conductors inductively couple with the inductor (116). A capacitor (82) and
optional trim capacitor (83) are connected across the the trough of the inductor (116) to form a
resonant LC circuit tuned to the resonance frequency. The LC circuit inductively couples with the
shield conductors (114) to present a high, signal attenuating impedance at the resonance frequency.
The resonant circuit is preferably contained in an RF-shielding box (84) with removable lid.
Composition especially in the form of emulsion, gel or aqueous solution, including a crosslinked poly(2acrylamido-2-methylpropanesulphonic acid) polymer neutralized to at least 90%
D-enantiomer of DFMO and methods of use therefor
The present invention concerns a method for preventing and/or treating cancer in a patient
comprising administering an effective amount of substantially purified D enantiomer of
difluoromethylornithine (D-DFMO) or an analog of D-DFMO to the patient. D-DFMO or an
analog thereof is administered at a dose of about 0.05 to about 20.0 gm/M.sup.2 /day. D-DFMO or
an analog thereof may be administered more than once for the treatment and/or prevention of
cancer. Methods of administration as well as compositions and formulations of substantially
purified D-DFMO and analogs of D-DFMO are described.
Portable reading light device
A portable reading light device utilizing an LEDs as the source of light mounted in a housing
having a single lens through which light from the LEDs is projected, the power to the LEDs being
controlled by Pulse Width Modulation.
Self-tanning composition containing an N-acyl amino acid ester and a self-tanning agent
The invention relates to cosmetic and/or dermatological compositions more particularly intended
for artificially tanning and/or browning the skin, comprising, in a cosmetically acceptable support,
at least one self-tanning agent and at least one N-acyl amino acid ester. The invention also relates to
a cosmetic treatment process for artificially tanning and/or browning the skin, comprising applying
to the skin an effective amount of the cosmetic and/or dermatological composition. The invention
also relates to the use of an N-acyl amino acid ester with the aim of improving the coloration and/or
stability of a self-tanning agent in a composition for artificially tanning and/or browning the skin.
Dibenzoylmethane sunscreen compositions containing photostabilizing amounts of tri-substituted butane
compounds
Improvedly photostable UV-photoprotecting cosmetic/dermatological compositions for the skin
and/or the hair contain (a) a UV-photoprotective amount of at least one dibenzoylmethane
sunscreen, e.g., 4-(tert-butyl)-4'-methoxydibenzoylmethane or 4-isopropyldibenzoylmethane,
advantageously (a') a UV-photoprotective amount of at least one 1,3,5-triazine sunscreen, e.g., 2[(p-(tert-butylamido]-4,6-bis[(p-(2'ethylhexyl-1'-oxycarbonyl)anilino]-1 ,3,5-triazine or 2,4,6tris[p-(2'-ethylhexyl-1'-oxycarbonyl)anilino]-1,3,5-triazine, (b) an effective sunscreen
photostabilizing amount of 1,1,1-tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane, formulated
into (c) a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.
Cosmetic or dermopharmaceutical use of peptides for healing, hydrating and improving skin appearance
during natural or induced ageing (heliodermia, pollution)
The invention concerns the use of peptides of general sequence X-Thr-Thr-Lys-Y, wherein in
particular X=lysine and Y=serine, in cosmetic or dermopharmaceutical compositions. It is
moreover advantageous to use said peptides in mutual combination. In order to enhance their
activity and their stability, the peptides are chemically modified to increase their lipophilicity, by
grafting on the N-terminal amine of X, either a fatty acid chain, or by esterification or amidation of
the C-terminal carboxyl group of Y. The peptides can be obtained by synthesis, biotechnology or
controlled hydrolysis or plant proteins. The resulting compositions are advantageously used for
stimulating healing, hydrating or all skin treatments. They are particularly active against formation
or deterioration of wrinkles and against all the consequences of skin ageing, whether natural or
induced (heliodermia, pollution), as well as for dry skin.
Synergistically UV-photoprotecting mixed sunscreen compositions
Topically applicable cosmetic/dermatological sunscreen composition well suited for the enhanced
UV-photoprotection of human skin and/or hair, contain synergistically UV-A.sub.PPD -enhancing
amounts of (i) at least one UV-screening silicon compound having a benzotriazole functional group
substituent, (ii) at least one UV-screening dibenzoylmethane compound, and (iii) at least one UVscreening amino-substituted 2-hydroxybenzophenone compound having the following structural
formula (III): ##STR1## formulated into (iv) a topically applicable, cosmetically/dermatologically
Synergistically UV-photoprotecting compositions comprising mixed screening agents
UV-photoprotection of human skin and/or hair contain synergistically UV-A.sub.PPD -enhancing
amounts of (a) particulates of at least one insoluble organic UV-screening agent having a particle
size ranging from 10 nm to 5 .mu.m, and (b) at least one UV-screening amino-substituted 2hydroxybenzophenone compound having the following structural formula (I): ##STR1##
formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent
Heat-removal method and apparatus for treatment of movement disorder episodes
Heat-removal method and apparatus for treatment of movement disorder episodes; more
specifically, a device and method for intracranially suppressing movement disorder episodes upon
the detection of physiological symptoms. The device includes a temperature-contact implanted at a
targeted portion in the brain which is determined to be associated with such episodes and
connection to an implanted heat-transfer operator, typically a Peltier cooler or a thermal-electric
cooler. Heat transfer from the temperature-contact to the heat-transfer operator cools the targeted
portion and suppresses the movement disorder episode. Such heat transfer is performed upon the
sensing of symptoms which normally preface episodes. The symptoms can be sensed intracranially
by sensing-contacts, on the skin by a sensor or by a person or animal. Alternatively, heat removal
(cooling) can be performed without sensing symptoms to prevent episodes when the patient is
particularly sensitive to, or in danger from, episodes.
Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label
The use of semiconductor nanocrystals as detectable labels in various chemical and biological
applications is disclosed. The methods find use for detecting a single analyte, as well as multiple
analytes by using more than one semiconductor nanocrystal as a detectable label, each of which
emits at a distinct wavelength.
Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
formula (I): ##STR1## in which Ar.sub.1 is a radical having one of the structural formulae (a)-(c):
##STR2## Ar.sub.2 is a radical having one of the following formulae (d)-(h): ##STR3## and X is a
radical having one of the following formulae (i)-(l): ##STR4## and are useful for the treatment of a
Stable/improvedly self-tanning compositions comprising amino-substituted 2-hydroxybenzophenone
compounds
Topically applicable cosmetic/dermatological self-tanning compositions well suited for enhancing
the coloration imparted by and/or the stabilizing of the self-tanning agent, contain (i) an effective
amount of at least one artificial/sunless tanning agent, and (ii) an effective stabilizing/enhancedly
self-tanning amount of at least one amino-substituted 2-hydroxybenzophenone compound having
the following structural formula (I): ##STR1## formulated into (iii) a topically applicable,
delivery.
Amino acid compounds and photoprotecting compositions comprised thereof
Amino acid compounds having the formula (I): ##STR1## are well suited for the UVphotoprotection of human skin and/or hair, as well as for the UV-photoprotection of a wide variety
of photosensitive industrial materials/substrates, e.g., plastics, glasses, textiles, etc.
Ultra-wideband monopole large-current radiator
An ultra-wideband, large-current radiator consisting of a ground plane and two electric monopoles:
a wide radiating monopole orthogonal to the ground plane, and a thin monopole orthogonal to the
ground plane and normally displaced from the wide monopole. The frequency-independent low
impedance of the antenna allows a small voltage to generate a large current. The wide radiating
monopole may be a flat sheet, or a sheet of parallel bars. Shielding by the wide monopole
suppresses radiation from the thin monopole into a sector of space into which the monopole
radiation characteristic of a well-formed impulse in response to a voltage step is desired. In one
preferred embodiment, two parallel flat sheets or a conducting cylinder is used as the wide radiating
monopole, further shielding radiation from the thin monopole.
Device for verifying the accuracy of a spectral analyzer
The present invention provides an artificial member (80, 210) which mimics the absorbance
spectrum of a body part and includes the spectral components of blood analytes. The artificial
member comprises a light scattering and reflecting material, and has a chamber portion comprising
one or more chambers (90, 100, 220). The artificial member is configured to be reproducibly
received in a measuring receptor which receptor is operatively connected to a non-invasive
monitoring device.
Use of amphoteric surfactants in cosmetic compositions to precipitate cationic polymers on dilution
REM sleep augmentation with extra-ocular light
The invention provides for exposing an extraocular (i.e., non-ocular) region of a human to light
during sleep which enhances REM sleep. Also provided are devices to carry out the methods. Key
timing parameters ensure effective REM enhancement without adversely impacting a subject's
circadian clock. The invention provides for improving cognitive function and performance in
healthy individuals, and in individuals suffering from a disease or disorder in which mental status is
compromised. One embodiment of the invention (100) includes a fiber optics pad (160) attached to
a power source, and lamp housing (120) by a fiber optics cable (140).
System and method for tissue treatment
A system and method for the treatment of body tissue is provided that includes a radiation-emitting
device and a massaging mechanism. In accordance with one embodiment, the radiation-emitting
device is a laser and the massaging mechanism is an automated mechanical massaging mechanism.
The radiation-emitting device can emit radiation in the visible and infrared wavelengths. The
radiation-emitting device can emit radiation in a concentric combination of infrared and visible
laser light. The method of using the tissue treatment system includes exposing a skin surface of a
patient to radiation emitted from the radiation-emitting device at predetermined wavelengths for
predetermined periods of time. The method further provides for massaging the exposed skin surface
of the patient with the massaging mechanism. The tissue treatment system can be utilized to effect
the reduction of excess cellulite.
Methods for preparing coated polyester articles
This invention relates to articles made of polyester, preferably polyethylene terephthalate (PET),
having coated directly to at least one of the surfaces thereof one or more layers of thermoplastic
material with good gas-barrier characteristics, and novel methods of making such articles.
Preferably the barrier-coated articles take the form of preforms coated by at least one layer of
barrier material and the containers blow-molded therefrom. Such barrier-coated containers are
preferably of the type to hold beverages such as soft drinks, beer or juice. The preferred barrier
materials have a lower permeability to oxygen and carbon dioxide than PET as well as key physical
properties similar to PET. The materials and methods provide that the barrier layers have good
adherence to PET, even during and after the blow molding process to form containers from
preforms. Preferred barrier coating materials include poly(hydroxyamino ethers). In one preferred
method, preforms are injection molded then barrier-coated immediately thereafter.
Topical application of chromophores for hair removal
A device and method is disclosed for permanent or semi-permanent removal of hair through the
activation of microparticles introduced into hair follicles. Microparticles are incorporated into a
composition that is topically applied to the skin. These microparticles containing or consisting of
chromophores or chemically activated molecules are of a variety of shapes and sizes.
Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50
microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin
without entering other areas of the skin, such as the stratum corneum or sweat gland channels.
Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means
activates the chromophore or chemically activated compounds, thus destroying the hair follicle
without damaging other areas of the skin. In another embodiment, microparticles further contain
nanoparticles released further into the hair follicle by use of a solvent or other method, allowing
chromophores or chemically activated molecules to penetrate deeper into the follicle and avoid
structures such as the sebaceous gland.
Skin protection agents containing a fragment mixture produced from hyaluronic acid by hydrolysis
The invention relates to an agent for the treatment, prophylaxis and metaphylaxis of functional and
structural disorders of the skin caused by external factors. The agent contains a hyaluronic acid
partially digested with a microbiological hyaluronate lyase. The hyaluronic acid fragment mixture
is incorporated in different galenic formulations to which other hydrophilic and/or lipophilic active
substances and/or auxiliary substances can be added. Fields of application of the invention in
human and veterinary medicine relate to the treatment and/or the prophylaxis of skin damage
caused by environmental factors including UV, dry skin conditions and skin ageing.
Nanoemulsion based on sugar fatty esters or on sugar fatty ethers and its uses in the cosmetics,
dermatological and/or ophthalmological fields
A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm,
comprising a surfactant which is solid at a temperature of less than or equal to 45.degree. C., which
surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a
sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the
amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be
used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or
mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye
lotion for treating the eyes.
Skin-mounted electrodes with nano spikes
Epidermally mountable device includes terminus structures to enable positive connection with
conductive tissue. The device includes nano spikes shaped to penetrate the epidermis of the skin to
collect electrical biopotentials such as cardiac depolarization waveforms (ECGs) and various
signals transmitted by implanted devices. Generally, the nano spikes are integrated on a substrate
comprising, preferably, a flexible metalized conductive plate attachable to an adhesive backing.
The device could be mounted on any external body of the patient to collect ECG, EEG or other
signals. Further, the device is adaptable to include a programmable microprocessor, including
memory and an antenna to store, receive and transmit data as needed. In one embodiment, in
addition to collecting physiologic data through direct contact, the device may also be used as a
smart patch to download, store and transfer data from implanted medical devices or other data
sources using wireless data transmission medium.
Treatment of hyperproliferative skin disorders and diseases
The invention relates to the use of one or more noble metals selected from silver, gold, platinum,
and palladium but most preferably silver, in a nanocrystalline form, for the treatment of a
hyperproliferative skin disorder or disease such as psoriasis. Among the noble metals, silver is
preferred for such treatment. The nanocrystalline noble metal of choice may be used in the form of
a nanocrystalline coating of one or more noble metals, a nanocrystalline powder of one or more
noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating
of one or more noble metals.
Porous inkjet recording system comprising ink-pigment-trapping surface layer
An inkjet recording system comprising a pigment-based ink in combination with a recording
element having a porous substrate with relatively large pores and a relatively thin overlying surface
layer which traps pigment particles, from an applied pigmented ink, at or near the surface while not
unduly restricting ink flow into the underlying porous substrate.
UV-photostabilized sunscreen compositions comprising dibenzoylmethane/triazine/benzophenone
compounds
UV-photoprotection of human skin and/or hair, are devoid of any p-methylbenzylidenecamphor,
but which contain (a) an effective photoprotecting amount of at least one UV-sunscreening
dibenzoylmethane compound, (b) an effective photoprotecting amount of at least one UV-screening
1,3,5-triazine compound normally photosensitive in the presence of a dibenzoylmethane compound
(a), and (c) an effective photostabilizing amount of at least one UV-screening amino-substituted 2hydrozybenzophenone compound having the following structural formula (VIII): ##STR1##
formulated into (d) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent
UV-photostabilized sunscreen compositions comprising dibenzoylmethane/benzophenone compounds
UV-photoprotection of human skin and/or hair are devoid of any p-methylbenzylidenecamphor, but
contain (a) an effective photoprotecting amount of at least one UV-screening dibenzoylmethane
compound, and (b) an effective photostabilizing amount of at least on UV-screening aminosubstituted 2-hydroxybenzophenone compound having the following structural formula (I):
##STR1## formulated into (c) a topically applicable, cosmetically/dermatologically acceptable
Artificial tanning compositions comprising sorghum extracts
Topically applicable, cosmetic/dermatological artificial tanning compositions devoid of certain
flavylium salts contain an effective artificial tanning amount of at least one sorghum extract
formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle therefor.
Method of treating hypotrophic scars enlarged pores
Skin including hypotrophic scars is irradiated with laser radiation having a wavelength between
about 525 and 550 nanometers. The irradiation is delivered at a fluence that stimulates wound
healing responses without actually inflicting a wound. The wound healing properties promote
growth of dermal extracellular matrix. Absorption properties of hemoglobin and melanin in the 525
to 550 nanometer wavelength range provide that wound healing response is concentrated close to
upper regions of the skin and accordingly close to the location of the scars. The growth of dermal
extracellular matrix "bulks-up" irradiated dermal tissue. This makes the depressions of hypertrophic
scars shallower and less apparent. The method has also been observed to cause shrinkage of
enlarged pores.
Synergistically UV-photoprotecting sunscreen compositions comprising camphorsulfonic
acid/benzophenone compounds
UV-photoprotection of human skin and/or hair, contain synergistically SPF-enhancing amounts of
(a) benzene-1,4-di(3-methylidene-10-camphorsulfonic acid), optionally in partially or completely
neutralized state, and (b) at least one amino-substituted 2-hydroxybenzophenone compound having
the following structural formula (I): ##STR1## formulated into (c) a topically applicable,
Disposable absorbent article having a skin care composition containing an enzyme inhibitor
An absorbent article, at least a portion of which comprises a skin care composition that comprises
an enzyme inhibitor and is at least partially transferred from the article to the skin of a wearer of the
article as a result of normal contact, wearer motion and/or body heat. The enzyme inhibitor is
transferred to the skin with the skin care composition and is available at the skin/urine and
skin/feces interfaces to inhibit enzymatic activity on the skin and to reduce or prevent the
occurrence of inflammation. Repeated application of similar treated articles to the wearer's skin
provides an available source with which the enzyme inhibitor transfers onto the skin continuously
over time and accumulates to provide a proactive defense against harmful enzymes for the
treatment and/or prevention of diaper dermatitis.
Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous
porphyrins
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites,
that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or
precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount
sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a
protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of
photoactivating wavelengths.
Hyaluronate lyase used for promoting penetration in topical agents
The invention relates to an agent for treating skin diseases and/or functional disorders of the skin on
the basis of different medicaments and/or auxiliary substances through promotion of penetration
from topical formulations into the skin. According to the invention, the agent is composed of a
hyaluronate lyase produced by microbial means and a medicament, preferably a hydrophilic
medicament and/or auxiliary substances in different galenic formulations including colloidal carrier
systems. The areas of application for the invention in human and veterinary medicament relate to
the treatment, prophylaxis and/or metaphylaxis of skin diseases, functional disorders of the skin,
the processes of skin ageing and dry skin conditions.
Anti-microbial body care product
An anti-microbial body care product comprising in the part contacting the human or animal skin
and/or mucosa and organic matrix containing homogeneously dispersed particles of a metallic
silver having a particle size in the range of 1 to 50 nm (silver nanoparticles) in an amount providing
on the surface of said part and anti-microbially effective but less than cytotoxic silver
concentration. Preferred body care products are disposable absorbent articles, toothbrushes,
cosmetic products and baby comforting products.
Process for forming thermal conductive sheet
Compositions for giving the skin a coloration similar to that of a natural tan, based on a pigment of the
monascus type, and uses thereof
A cosmetic and/or dermatological composition that produces on the skin a long-lasting and noncovering coloration similar to that of a natural tan comprising, in a cosmetically acceptable
medium, at least one pigment, which may be obtained by extraction with an organic or aqueousorganic solvent of a culture medium of micromycetes of the Monascus type, as well as the use of
the composition for giving the skin a long-lasting and non-covering coloration similar to that of
naturally tanned skin.
acrylonitrile
cosmetically acceptable support, at least one compound of formula (1) or (2) ##STR1## in which
X.sub.1 represents R.sub.3 --(C.dbd.O)--, R.sub.3 --SO.sub.2 -- or R.sub.3 --O--(C.dbd.O)--,
X.sub.2 represents --(C.dbd.O)--R'.sub.3 --(C.dbd.O)--, --SO.sub.2 --R'.sub.3 --SO.sub.2 -- or -(C.dbd.O)--O--R'.sub.3 --O--(C.dbd.O)--, Y represents --(C.dbd.O)--R.sub.4 or --SO.sub.2 R.sub.5,
Photoprotective/cosmetic compositions comprising dibenzoylmethane/triazine/diphenylacrylate
compounds
suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UVA and UV-B irradiation, particularly solar radiation, comprise (i) 4-tert-butyl-4'methoxydibenzoylmethane, (ii) at least one particular 1,3,5-triazine compound, and (iii) at least one
alkyl .alpha.-cyano-.beta.,.beta.'-diphenylacrylate, formulated in a cosmetically/dermatologically
Stabilzation method of nano-sized emulsion using tocopheryl derivatives and external application for
skin containing the same
Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl
derivatives represented by the following formula (I) and ##STR1## (Wherein, R.sub.1, R.sub.2 and
R.sub.3 are H or methyl group, and at least one position selected from the group consisting of the
R.sub.1, R.sub.2 and R.sub.3 positions are methyl group; and, A is CH.sub.2 --CH(CH.sub.3)-- or
CH.dbd.C(CH.sub.3)--) and an external application for skin containing the stabilized nano-sized
emulsion.
Silicon compounds derived from ascorbic acid
The invention concerns novel silicon compounds derived from ascorbic acid consisting of a siliconcontaining chain or of silanes, comprising at least a radical A of formula (I) wherein: at least one of
the radicals L is a divalent radical for fixing A on the silicon chain. The invention further concerns
methods for preparing said compounds, compositions, in particular cosmetic or pharmaceutical,
containing them, and their use as antioxidant and/or anti-free radical agent, particularly for treating
oxidant stress, for treating the effects of exposure to the sun and for preventing ageing. ##STR1##
Sensors employing nanoparticles and microcavities
An optical sensing enhancing material (and corresponding method of making) comprising: a
medium, the medium comprising a plurality of aggregated nanoparticles comprising fractals; and a
microcavity, wherein the medium is located in a vicinity of the microcavity. Also an optical sensor
and sensing method comprising: providing a doped medium, the medium comprising a plurality of
aggregated nanoparticles comprising fractals, with the material; locating the doped medium in the
vicinity of a microcavity; exciting the doped medium with a light source; and detecting light
reflected from the doped medium.
Integrated lancing and analytic device
This invention provides for an integrated device having a lance and analytic device in a single
disposable unit where the lance releases fluid from skin and the analytic device collects and
analyzes the fluid without the user removing an instrument housing which holds the disposable
unit. In addition to the device, this invention provides for methods of using and manufacturing the
device.
Low frequency modulation sensors using nanosecond fluorophores
Described is a new approach to fluorescence sensing based on a mixture of fluorophores, one of
which is sensitive to the desired analyte. If a long lifetime analyte-insensitive fluorophore is mixed
with a short lifetime analyte-sensitive fluorophore, the modulation of the emission at conveniently
low frequencies becomes equal to the fractional fluorescence intensity of the sensing fluorophore.
Under these conditions the modulation can be used to determine the analyte concentration. This can
be used with any fluorophore which changes intensity in response to analyte, and does not require
the sensing fluorophore to display a change in lifetime. The feasibility of modulation-based sensing
was demonstrated using mixtures of 6-carboxyfluorescein and [Ru2,2'(bipyridyl).sub.3 ].sup.2+ as
a pH sensor and of the calcium probe Fluo-3 and [Ru2,2'(bipyridyl).sub.3 ].sup.2+ as a calcium
sensor.
Laser treatment for reducing wrinkles
Skin including wrinkles is irradiated with laser radiation having a wavelength between about 525
and 550 nanometers. The irradiation is delivered at a fluence that stimulates wound healing
responses without actually inflicting a wound. This promotes deposition of dermal extracellular
matrix. Absorption properties of hemoglobin and melanin in the 525 to 550 nanometer wavelength
range provide that wound healing response is concentrated close to upper regions of the skin and
accordingly close to the location of the wrinkles. The growth of dermal extracellular matrix "bulksup" irradiated dermal tissue. This makes the depressions or folds of the wrinkles shallower and less
apparent.
Synthetic roofing shingle or tile
A synthetic roofing shingle or tile is provided, in which a core material is formed, of generally less
expensive material, and with a skin material provided, disposed thereabout, with the skin material
being generally of greater expense and having desirable weather-withstanding qualities.
Portable light delivery apparatus and methods for delivering light to the human body
A device is provided for delivering light to the blood supply of a human body through a non-ocular
skin area. The device has a plurality of light emitting diodes (LEDs) spaced apart from each other
and extending through apertures for emitting light to the body and a power supply connected to the
light delivery unit. The device provides wavelengths of light within a specifically-determined range
of intensity and a specifically-determined angles of illumination. Devices may be included for
controlling and programming the output of the LEDs. A method is provided for delivering light to a
non-ocular body region for treating jaundice, breaking down bilirubin and treating other disorders.
LED light source-based instrument for non-invasive blood analyte determination
A compact, lightweight instrument for non-invasive blood analyte determination employs a light
source incorporating an assembly of LED's interconnected within a thermally stable substrate. A
large diameter mixer couples the signal to a fiber optic probe for delivering the signal to a tissue
measurement site. Back-diffused light is collected and dispersed across an array of photo detectors
in a miniature spectrometer instrument. A high-speed DSP executes an algorithm for predicting
concentration of a target analyte, which is output to a LCD display. Instrument control is by means
of keypad or voice recognition. High conversion efficiency of the light source results in extremely
low power dissipation and virtually no heat generation, making incorporation of the light source
and the spectrometer into a single unit practicable. High-speed pulsing of the signal allows
application of high-sensitivity, synchronous detection techniques. Speed and flexibility in
sequencing LED's allows simultaneous measurement and skin temperature control.
USE OF AMPHIPHILIC COPOLYMERS TO STABILIZE DISPERSIONS OF INSOLUBLE
ORGANIC COMPOUNDS FOR SCREENING OUT UV RADIATION, DISPERSIONS STABILIZED
WITH THESE COPOLYMERS AND COSMETIC COMPOSITIONS CONTAINING THEM
The invention relates to the use of at least one amphiphilic copolymer comprising at least one
hydrophilic block and at least one hydrophobic block to stabilize dispersions of insoluble organic
compounds comprising at least one group that absorbs UV radiation, which is in the form of
particles with a mean size of between 10 nm and 5 .mu.m, and also to dispersions stabilized with
these amphiphilic copolymers and to cosmetic compositions for topical application, in particular
antisun compositions, containing them.
Multi component controlled delivery system for soap bars
The present invention relates to an improved controlled delivery system that can be incorporated in
soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier
system also provides controlled release or prolonged release of these actives from the skin over an
extended period of time. The controlled delivery system of the present invention comprises
substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of
encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high
cationic charge density of the nanosphere improves deposition of active ingredients onto skin. The
high cationic charge density on the nanosphere surface is created by incorporating a cationic
conditioning agent into the solid hydrophobic matrix of the nanospheres, by incorporating a
cationic charge "booster" in the moisture sensitive microsphere matrix, or by using a cationic
conditioning agent in the nanosphere matrix in conjunction with a cationic charge "booster" in the
microsphere matrix. The invention also pertains to soap products comprising the controlled release
system of the present invention.
Method of stimulating epithelial cells using keratinocyte growth factor (KGF) and method of inhibiting
KGF activity
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used
sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of
other polypeptides. These proteins can be produced in various functional forms from spontaneously
secreting cells or from DNA segments introduced into cells. These forms variously enable
biochemical and functional studies of this novel protein as well as production of antibodies. Means
are described for determining the level of expression of genes for the KGF protein, for example, by
measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.
Sunscreen compositions comprising mineral oxides having hydrophobic coatings and glycosidesubstituted polydimethylsiloxanes
Stable, topically applicable cosmetic/dermatological compositions, notably W/O emulsions, well
suited for the UV-photoprotection of the skin, lips and/or the hair, and/or for the makeup of the skin
and/or the lips, contain a thus effective amount of at least one mineral oxide having a hydrophobic
coating thereon, e.g., coated particulates of an oxide of titanium and/or zinc, and, as a stabilizing
agent therefor, a thus effective amount of at least one oxyalkylenated polydimethylsiloxane bearing
at least one glycoside residue substituent, formulated into a physiologically acceptable medium
therefor.
Synergistically high SPF photoprotective UV-screening compositions comprising benzotriazolesubstituted silicon/dibenzoylmethane/diarylbutadiene compounds
Topically applicable, enhanced SPF cosmetic/dermatological UV-screening compositions suited for
the photoprotection of the skin and/or hair, comprise, (i) at least one UV-screening benzotriazolesubstituted silicon compound, as a first screening agent; (ii) at least one UV-screening
dibenzoylmethane compound, as a second screening agent; (iii) at least one 4,4-diarylbutadiene
compound, as a third screening agent, formulated into a topically applicable,
cosmetically/dermatologically acceptable vehicle therefor.
Photoprotective cosmetic compositions comprising inorganic UV-blocking agents
Stable photoprotective cosmetic emulsions, notably water-in-oil emulsions well suited for the UVphotoprotection of the skin, lips, mucous membranes and/or hair, contain at least one aqueous
phase, at least one oily phase, an effective UV-photoprotecting amount of at least one coated or
uncoated metal oxide UV-blocking agent and an effective stabilizing amount of at least one
amphiphilic oligomer or polymer derived from a polyolefin which also comprises at least one polar
moiety, formulated into a physiologically acceptable medium therefor.
Use of nanoscalar water-soluble .beta.-(1,3) glucans
The invention relates to the use of nanoscalar water-soluble .beta.-(1,3) glucans, which are
essentially free from .beta.-(1,6) links and have particle diameters ranging from 10 to 300 nm for
producing cosmetic and/or pharmaceutical preparations. When applied topically, the especially fine
dispersion of the particles, compared to prior art glucans, facilitates their rapid penetration of both
the stratum corneum of the skin and the keratin fibres of the hair.
Fluoropolymer extrusions based on novel combinations of process parameters and clay minerals
A process for extruding of products from fluoropolymers preferably shaped as rods or tubes which
have unique physical and other properties resulting from the addition of nanoparticles under unique
processing conditions while also utilizing accurate control of processing parameters such as time
and temperature and others according to novel methods.
Cosmetic care or makeup composition for a keratin material comprising at least one photoprotective
agent and at least one ester comprising an aromatic group
A cosmetic care or makeup composition for keratin materials comprising, in a physiologically
acceptable medium, at least one photoprotective agent capable of screening out UV radiation and at
least one ester comprising an aromatic group, which is liquid at room temperature, resulting from
the esterification of an aromatic acid with at least one hydroxyl group chosen from pendent
hydroxyl group and terminal hydroxyl groups of hydroxylated aliphatic compounds said
hydroxylated aliphatic compounds being chosen from hydroxylated aliphatic acids and esters
thereof. Use of the said ester comprising an aromatic group to improve the photoprotective power
of compositions intended for protecting the skin and/or the lips and/or integuments against UV
radiation.
Cosmetic/dermatological compositions comprising a tetrahydrocurcuminoid and an amide oil
The invention relates to a cosmetic or dermatological composition containing a carrier comprising
at least one fatty phase characterized in that it contains at least one derivative or a mixture of
derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure and at least one oil
having, in its structure, at least one amide unit. The invention also relates to its uses in cosmetics
and dermatology, in particular for preventing or combating the harmful effects of UV radiation and
pollution on human keratinous materials, and more particularly for preventing and/or treating
photoaging of the skin. The invention also relates to a method for solubilizing a derivative or a
mixture of derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure with at least
one oil having, in its structure, at least one amide unit.
Hard top produced by method for vacuum pressure forming reinforced plastic articles
A hollow, reinforced, molded automotive hard top is made using a sheet of thermoplastic material
with nanoparticles dispersed therein. The particles comprise less than 15% of total volume of the
plastic sheet, at least 50% of the particles have a thickness less than about 20 layers, and at least
99% of the particles have a thickness of less than about 30 layers. The sheet is preheated and
molded in an assembly having mold surfaces corresponding to the hard top configuration. Vacuum
is applied to one side of the assembly and pressurized gas is applied to the opposite side of the
assembly to force the sheet into conformity with the mold surfaces. After cooling, the conformed
sheet is transferred to another mold assembly, where a reinforced plastic melt having a blowing
agent is applied. Together, the solidified melt and the conformed plastic sheet form the hard top.
Self-tanning composition containing a tetrahydrocurcuminoid and a self-tanning agent
The present invention relates to a cosmetic and/or dermatological composition more particularly
intended for artificially tanning and/or browning the skin and comprising, in a cosmetically
acceptable support, at least one derivative or a mixture of derivatives of 1,7-bisphenyl heptane-3,5dione of particular structure and at least one self-tanning agent. The present invention also relates to
a cosmetic treatment process for artificially tanning or browning the skin and to the use of at least
one derivative or a mixture of derivatives of 1,7-bisphenyl heptane-3,5-dione of particular structure
for improving the coloration and/or stability of a self-tanning agent. The invention also relates to
the uses of these compositions for giving the skin a coloration close to that of a natural skin tan.
Resorcinol composition
The present invention relates to the use of a resorcinol derivative, i.e., 4-(2,4dihydroxyphenyl)cyclohexanol, or a pharmaceutically acceptable salt thereof, as a skin lightening
agent.
Silicone-coated organic solvent resistant polyamide composite nanofiltration membrane, and method for
preparing the same
The present invention relates to a silicone-coated organic solvent resistant polyamide composite
nanofiltration membrane and a method for preparing the same. More particularly, the present
invention relates to a nanofiltration composite membrane that is not only rejection rate superior but
also organic solvent stable and flux excellent, prepared by coating with silicone during the process
of interfacial polymerization of polyamide on the surface of porous support; and a method for
producing it.
Wearable electro-ionic protector against inhaled pathogens
A device for removing airborne contaminants and inhaled biopathogens, particularly particulate or
aerosol contaminants, from respired air that can be either stationary or incorporated into a garment
or accessory worn upon the body. In a preferred embodiment, a negative electrode is connected to
voltage multiplier and modulation circuit and then to a discharge electrode having an electron
emissive surface disposed near the wearer's airway. The positive (counter) electrode is similarly
disposed away from the airway such as, for example, near the forehead. Electrons, ejected from the
electron emissive surface, transfer a negative charge to airborne particulate contaminants which are
accelerated toward, and collected by, the counter electrode.
Aqueous antisun/sunscreen compositions comprising amphiphilic 2-acrylamidomethylpropanesulfonic
acid polymers and water-soluble silicones
Photoprotective compositions well suited for the photoprotection of the skin, lips and/or hair
against the damaging effect of UV-radiation comprise at least one aqueous phase and at least one
system for screening out UV-radiation, and which also contain: (a) at least one partially or totally
neutralized, crosslinked or non-crosslinked amphiphilic polymer of 2acrylamidomethylpropanesulfonic acid (AMPS), and (b) at least one water-soluble silicone
comprising at least one terminal or pendent monovalent polyoxyalkylene group.
Translucent nanoemulsion, production method, and uses thereof in the cosmetic, dermatological and/or
The nanoemulsion according to the invention comprises an oily phase dispersed in an aqueous
phase, having oil globules with a number-average size less than 100 nm, characterized in that it
contains a ternary surfactant system comprising: a) a mixture of at least two nonionic surfactants
comprising at least one ethoxylated fatty ester comprising 8 to 100 ethylene oxide units and at least
one fatty acid ester of sorbitan; and b) at least one ionic surfactant chosen from alkali metal salts of
cetyl phosphate and alkali metal salts of palmitoyl sarcosinate. Use in the manufacture of cosmetic,
dermatological and ophthalmological compositions.
Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a
biodegradable-bio-compatable polymeric matrix
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be
programmed to release their active core for variable durations ranging from 1-100 days in an
aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or
other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer
having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a
pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and endcapped forms ranging to ratios from 100/0 to 1/99.
Aqueous photoprotective compositions comprising acrylamido-2-methylpropanesulfonic acid polymers
and 4,4-diarylbutadiene UV-A sunscreens
at least one aqueous phase, at least one oily phase, at least one partially or completely neutralized,
crosslinked or non-crosslinked water-soluble or water-dispersible acrylamido-2methylpropanesulfonic acid (AMPS) polymer and at least one UV radiation-screening system, said
at least one screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent
Deodorizing preparations containing nanosacle chitosans and/or chitosan derivatives
A deodorizing composition containing an ingredient selected from the group consisting of a
nanoscale chitosan having a particle diameter of from about 1 to 300 nm, a nanoscale chitosan
derivative having a particle diameter of from about 1 to 300 nm, and mixtures thereof.
Non-spherical nanopowder derived nanocomposites
Nanocomposites from nanofillers with preferred form of whiskers, rods, plates and fibers are
disclosed. The matrix composition described includes polymers, ceramics and metals. The
composition disclosed include inorganic, organic and metallic. These nanocomposites are useful in
wide range of applications given their unusual properties such as refractive index, transparency to
light, reflection characteristics, resistivity, permittivity, permeability, coercivity, B-H product,
magnetic hysteresis, breakdown voltage, skin depth, curie temperature, dissipation factor, work
function, band gap, electromagnetic shielding effectiveness, radiation hardness, chemical reactivity,
thermal conductivity, temperature coefficient of an electrical property, voltage coefficient of an
electrical property, thermal shock resistance, biocompatibility, and wear rate.
Sunscreen milk
The invention concerns a cosmetic or dermatological composition for protection against ultraviolet
radiation, based on inorganic screening agent, characterized in that it comprises a water-in-oil
emulsion containing a combination of at least a particulate inorganic sunscreening agent, selected
among the group consisting of titanium dioxide, zinc oxide and mixtures thereof, and at least an
emulsifier selected among the group consisting of silicone derivatives with glycosidic constituent,
the particulate screening agent being homogeneously dispersed in the water-in-oil emulsion.
Heteroethynylenic compounds and pharmaceutical and cosmetic compositions containing them
The invention relates to novel heteroethynylenic compounds having the general formula (I):
##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for
use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and
ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Venoscope apparatus
An improved instrument for viewing subcutaneous venous structure, known as a VENOSCOPE,
which includes a clamshell housing, having a first fixed arm extending therefrom, and a second
movable arm captured by upper and lower portions of the housing; a first high intensity plurality of
white and red LEDs positioned at the end of the first arm, and a second high intensity plurality of
high intensity red and white LED positioned at the end of the second arm, and a battery positioned
within the housing for selectively provided electrical energy to the red and white LEDs, so that a
more defined and intensely illuminated field of visualization between structures below the skin and
the surrounding subcutaneous tissue is defined. Additional embodiments include a tube or handle
connected to a head having multiple arms or a single arm with multiple LEDs.
Treatment of inflammatory skin conditions
The invention relates to the use of one or more antimicrobial metals, most preferably silver,
preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment
of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in
the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder
of one or more antimicrobial metals, or a solution containing dissolved species from a
Packaging and application device
Packaging and application device comprising a container having an internal space (12) in which the
product (P) is contained, an application element (16), a housing (14) for housing the application
element and a permeable wall (23) placed between the said housing and the internal space
containing the product. The application element and the housing are both designed in such a way
that the application element has, when it is in the said housing, at least one surface portion (16a)
located, without any appreciable axial compression, opposite an opening (25) in the permeable
wall. The internal space is a variable-volume space, compression means being provided for making
the said internal volume pass selectively from a first volume, greater than the volume of product, to
a second volume, smaller than the first, this reduction in volume being accompanied by an
overpressure which is conducive to transferring product through the said permeable wall towards
the application element.
Methods of enhancing radiation effects with metal nanoparticles
The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to
enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of
ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously,
intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal
nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to
the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or
cells ex vivo.
Photoprotective compositions comprising sulfonic/hydrophobic amphiphilic polymers
Photoprotective cosmetic/dermatological compositions well suited for the UV-photoprotection of
human skin and/or hair, comprise (a) at least one organic UV-screening agent and (b) an SPFimproving amount of at least one amphiphilic polymerizate of at least one ethylenically unsaturated
monomer which comprises a sulfonic group, whether in the free acid or in partially or totally
neutralized state, and which amphiphilic polymerizate also comprises at least one hydrophobic
moiety.
Examination of scattering properties of biological tissue
This invention is a scheme for monitoring a solute in a biological system comprising the steps of
delivering light into a biological system (12) containing a solute, the light having a wavelength
selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first
and second portions of the delivered light, the first portion having traveled through the biological
system along one or more paths characterized by a first average path length, and the second portion
having traveled through the biological system along one or more paths characterized by a second
average path length that is greater than the first average path length; and comparing the first and
second portions of the delivered light to monitor concentration of the solute in the biological
system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes,
generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol,
propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).
Antimicrobial yarn having nanosilver particles and methods for manufacturing the same
The present invention provides a yarn with antimicrobial effects. The antimicrobial antifungal
effect of the yarn is derived from nanosilver particles (diameter between 1 and 100 nm) which are
adhered to the yarn. The yarn contains fibers which are made of cotton, linen, silk, wool, leather,
blending fabric, synthetic fiber, or any combination thereof. The yarn can be used to make cloth to
be used particularly for treating patients with burns or wound. The cloth made from the
antimicrobial yarn can be further used to make clothes such as underwears, socks, shoe cushions,
shoe linings, bed sheets, pillow cases, towels, women hygiene products, laboratory coats, and
medical robes. The present invention also provides a method for making the antimicrobial yarn.
Photostable UV-screening compositions comprising dibenzoylmethane/diarylbutadiene compounds
Topically applicable, photostable cosmetic/dermatological UV-screening compositions comprise
(a) at least one photolabile UV-screening dibenzoylmethane compound and (b) a dibenzoylmethane
photostabilizing amount of at least one 4,4-diarylbutadiene compound, formulated into a topically
applicable, cosmetically/dermatologically acceptable support therefor; the weight ratio of the 4,4diarylbutadiene compound(s) to the diarylbutadiene compound(s) is characteristically greater than
2.5 and the subject compositions are advantageously devoid of any cinnamate sunscreen.
Low profile combination device for gastrostomy or jejunostomy applications having anti-granuloma
formation characteristics
A combination device for gastrostomy or jejunostomy usage having a retaining member, an
elongated member having a gastrostomy lumen and a jejustomy lumen, and an inflatable balloon
mounted on the elongated member. The retaining member is of a low profile and is arranged to be
located on the skin adjacent a stoma in the abdominal wall through which the elongated member
extends. The balloon seals the stoma about the elongated member. The retaining member includes
at least one access port to communicate with respective ones of the lumens. The device, related
compositions, and processes can prevent and/or treat granulomas.
Compounds and methods for inhibition of phospholipase A.sub.2 and cyclooxygenase - 2
The present invention comprises a group of related lipid molecules, and methods for their use, that
maybe used to treat inflammation and certain inflammation related diseases. The group of related
lipid molecules are capable of inhibiting certain enzyme systems including phospholipase A.sub.2,
and cyclooxygenase-2. The group of related lipid molecules of the invention may be characterized
by specific structural characteristics, or by specific biological activity, including inhibition of the
previously listed enzymes.
Nanoemulsion containing nonionic polymers, and its uses
These objects and others may be accomplished with the present invention, the first embodiment of
which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an
aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic
amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one watersoluble nonionic polymer selected from the group including homopolymers and copolymers of
ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone;
homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl
methyl ether; neutral acrylic homopolymers and copolymers; C.sub.1 C.sub.2 alkyl celluloses and
their derivatives; C.sub.1 C.sub.3 alkyl guar; C.sub.1 C.sub.3 hydroxyalkyl guar; and combinations
thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i)
ranges from 1.2 to 10; and wherein the oily phase includes oil globules having a number-average
size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on
storage. It may form a composition for topical, preferably cosmetic or dermatological
compositions, pharmaceutical compositions and ophthalmological compositions.
Autonomous, ambulatory analyte monitor or drug delivery device
The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The
invention is suited for monitoring various blood constituents such as glucose. The device has a
housing that at least partially encloses a plurality of microneedles disposed on a carrier and an
electronics portion. Each microneedle is in fluid communication with a corresponding
microchannel. Each microneedle is individually addressable. That is, each microneedle can be
extended and retracted individually via an actuator. The electronics portion includes a processor
and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a
sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls
the operation of the device and is data communication with the actuator, motor, sensor and
interface. The invention provides for autonomous operation, that is, without intervention of the
user. The invention can optionally provide for calibration without intervention of the user. The
invention can also provide for semi-continuous monitoring for day and night time. The invention
can provide for up to four, or more, weeks of operation. The invention can provide for a device that
is relative small in size, and therefore unobtrusive. The invention can also provide for device with
remote control and interactive electronics. The invention may be also used for the delivery of
various pharmaceutical agents including high potency drugs to minimize patient intervention and
minimize discomfort.
Artificial tanning emulsions comprising sorghum extracts/organomodified silicones
Topically applicable, cosmetic/dermatological artificial tanning emulsions devoid of certain
flavylium salts include (a) at least one aqueous phase and (b) at least one fatty phase, (c) an
effective artificial tanning amount of at least one sorghum extract, and (d) at least one
organomodified silicone.
Non-uniform thickness electroactive device
An electroactive device comprises at least two layers of material, wherein at least one layer is an
electroactive material and wherein at least one layer is of non-uniform thickness. The device can be
produced in various sizes, ranging from large structural actuators to microscale or nanoscale
devices. The applied voltage to the device in combination with the non-uniform thickness of at least
one of the layers (electroactive and/or non-electroactive) controls the contour of the actuated
device. The effective electric field is a mathematical function of the local layer thickness.
Therefore, the local strain and the local bending/torsion curvature are also a mathematical function
of the local thickness. Hence the thinnest portion of the actuator offers the largest bending and/or
torsion response. Tailoring of the layer thicknesses can enable complex motions to be achieved.
System and method for tissue treatment
A system and method for the treatment of body tissue is provided that includes a radiation-emitting
device and a massaging mechanism. In accordance with one embodiment, the radiation-emitting
device is a laser and the massaging mechanism is an automated mechanical massaging mechanism.
The radiation-emitting device can emit radiation in one or both of the visible and infrared
wavelengths. The radiation-emitting device can emit radiation in a concentric combination of
infrared and visible laser light. The method of using the tissue treatment system includes exposing a
skin surface of a patient to radiation emitted from the radiation-emitting device at predetermined
wavelengths for predetermined periods of time. The method further provides for massaging the
exposed skin surface of the patient with the massaging mechanism. The tissue treatment system can
be utilized to effect the reduction of excess cellulite.
Stabilized derivatives of ascorbic acid-3-phosphate
Novel derivatives of ascorbic acid and compositions comprising them are provided. The novel
derivatives are of the following general formula (I): where R1 is a C2 C22 saturated or unsaturated
fatty acid residues, amino acid residues, or a C1 C17 alkyl ; R2 is a group of the following formula
(II) wherein R5 or R6 are the same or different and represent hydrogen, a C1 C4 alkyl, or R5 is C1
C4 alkyl group and R6 is a metal cation or ammonium cation; R3 or R4 are the same or different
and represent hydrogen, C2 C22 saturated or unsaturated fatty acid residues, amino acid residues,
or a C1 C17 alkyl.
Optical element with nanoparticles
Disclosed is an optical element comprising a substrate with surface features on a surface thereof
having an Ra of from 3 to 200 micrometers containing a dispersion of minute particles having a
particle size dimension less than 100 nanometers.
Analyte concentration detection devices and methods
Arrangements for the detection of the presence and/or concentration of an analyte in a sample of
bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination
arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a
detection component that can be in the form of an array of optical detection elements. A number of
assay pad constructions are described which may include at least one or more of the following
components: a prefilter component, a reflective component, a membrane component, a reagent
component, a mesh component, and a component to prevent lateral spreading.
Methods of fabricating physiological sample collection devices
Methods of fabricating devices for collecting a sample of physiological and for measuring a
characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are
in the form of a test strip which include a biosensor and at least one skin-piercing element which is
a planar extension of a portion of the biosensor. The fabrication methods provide various or
forming the test strip and the skin-piercing element.
Selective photothermolysis
Performing selective photothermolysis of sub-cutaneous tissue by using a plurality of beams of
narrow band electro-magnetic radiation, where each of the beams have energy that is insufficient to
heat the tissue that they strike to a temperature high enough to destroy such tissue, but by directing
the individual beams to overlap at the target sufficient heat is generated to destroy the target tissue.
Multi component moisture triggered controlled release system that imparts long lasting cooling sensation
on the target site and/or provides high impact fragrance or flavor burst
The present invention relates to cosmetic formulations comprising a multi component controlled
release system that imparts long lasting cooling sensation and/or provides high odor or flavor
intensity (i.e., high impact fragrance or flavor burst) in response to moisture. The controlled
hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres.
Multi component controlled release system for anhydrous cosmetic compositions
The present invention relates to an improved controlled release system that can be incorporated into
anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors, active
ingredients, or combinations of fragrances, flavors, and various active ingredients. The controlled
hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres. The
fragrances, flavors, and active ingredients encapsulated in the nano-spheres can be the same or
different from those encapsulated in the micro-sphere. The encapsulation of one or more
fragrances, flavors or active agents in the various components of the system, such as nano-spheres
and micro-spheres, provides odor or flavor transition (change in odor character or change in flavor
character) during the use of the product, in response to moisture, such as wetting the lips,
perspiration, and the like. The incorporation of the controlled release system of the present
invention into anhydrous cosmetic formulations was found to provide moisture triggered release, as
well as prolonged release of the fragrances, flavors, and active ingredients that are encapsulated in
the solid hydrophobic nano-spheres over an extended period of time.
Hyaluronic acid in the treatment of cancer
The present invention relates to a composition and method comprising purified HA, a second antineoplastic agent and a pharmaceutically acceptable carrier, wherein the purified HA and the second
anti-neoplastic agent are administered to a mammal having cancer in an amount effective to treat
the cancer.
Test method for assessing irritation of skin
Test methods for assessing irritation of portions of skin and/or assessing inhibition and/or reduction
of such irritation are provided.
Photoprotective UV-screening compositions comprising (phenylsulfonyl) acrylonitrile-substituted
silanes/siloxanes
Novel (phenylsulfonyl)acrylonitrile siloxanes/silanes, and cosmetic/dermatological sunscreen
compositions comprised thereof, are well suited for UV-A photoprotecting the skin and/or the hair
against the damaging effects of solar radiation.
insoluble polyorganosiloxane conditioning polymer, process therefor and use thereof
Disclosed herein is a composition comprising at least one fluorescent dye and at least one insoluble
polyorganosiloxane conditioning polymer, processes using this composition, and a device.Further
disclosed herein is the use of compositions comprising at least one fluorescent dye and at least one
insoluble polyorganosiloxane conditioning polymer, for dyeing human keratin materials, for
example artificially dyed and/or pigmented hair and dark skin, with a tightening effect.
Formulation of UV absorbers by incorporation in solid lipid nanoparticles
Solid lipid nanoparticle compositions containing (a) 1 to 40% by weight of an oil-soluble UV
absorber, (b) 20 to 98.9% by weight of a solid lipid, (c) 0.1 to 20% by weight of an emulsifier and
(d) 0 to 40% by weight of a liquid lipid or a liquid oil-miscible UV absorberThe compositions
according to the invention enhance the solubility behaviour of oil-soluble UV filters in cosmetic
formulations and thereby also improve their effectiveness.
Composition for dyeing a human keratin material, comprising at least one fluorescent dye and at least
one insoluble conditioning agent, process thereof, use thereof, and devices thereof
A composition comprising at least one fluorescent dye and at least one insoluble conditioning
agent; and processes and multicompartment kits comprising the composition. This disclosure also
relates to the use of this composition for dyeing a human keratin material, and, for example,
artificially dyed or pigmented hair and/or dark skin, with a lightening effect.
Method, system and module for monitoring a power generating system
active material.
Dibenzoylmethane sunscreen compositions photostabilized with amphiphilic block copolymers
Topically applicable photostable sunscreen/photoprotective compositions contain at least one
dibenzoylmethane UV-sunscreen and an effective photostabilizing amount therefor of at least one
amphiphilic block copolymer which comprises at least one nonionic hydrophilic polymer block and
at least one hydrophobic polymer block, formulated into a topically applicable, cosmetically
acceptable medium therefor.
Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic
sunscreen particles/diarylbutadiene compounds
Topically applicable high SPF cosmetic/dermatological UV-screening compositions suited for the
photoprotection of the skin and/or hair, comprise (a) particulates of at least one insoluble organic
UV-screening agent having a particle size ranging from 10 nm to 5 .mu.m, as a first screening
agent, and (b) at least one 4,4-diarylbutadiene compound, as a second screening agent, formulated
into a topically applicable, cosmetically/dermatologically acceptable vehicle therefor.
Photoprotective UV-screening compositions comprising triazine/dibenzoylmethane/diarylbutadiene
compounds
Topically applicable, photostable cosmetic/dermatological UV-screening compositions suited for
photoprotecting the skin and the hair, comprise (a) at least one UV-screening dibenzoylmethane
compound, (b) at least one UV-screening 1,3,5-triazine compound that is photosensitive in the
presence of a dibenzoylmethane compound, and (c) a 1,3,5-triazine photostabilizing amount of at
least one 4,4-diarylbutadiene compound, formulated into a topically applicable,
cosmetically/dermatologically acceptable support therefor; the weight ratio of the 4,4diarylbutadiene compound(s) to the dibenzoylmethane compound(s) is characteristically greater
than 2.5 and the subject compositions are advantageously devoid of any cinnamate sunscreen.
Sunscreen composition with enhanced SPF and water resistant properties
The present invention relates to a sunscreen formulation which exhibits superior ultraviolet
protection and water resistance than prior art sunscreen compositions. The sunscreen formulation
comprises (a) a dispersion comprising a sunscreen active agent and (b) a base composition
comprising a rheological modifying agent and water. The sunscreen formulation is substantially
free of surfactants. According to a preferred embodiment, the sunscreen active agent is
ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, or a combination thereof. The
sunscreen formulation preferably comprises a phosphorylated starch derivative as a rheological
modifying agent. Another embodiment of the present invention is a method of protecting skin or
hair from ultraviolet radiation by applying an effective amount of the sunscreen formulation of the
present invention to the skin or hair.
Cosmetic dermabrasion treatment system
The present invention provides a complementary three-step dermabrasion system that provides
treatment for skin conditions such as acne scars, wound scars, and other visually unappealing skin
disfigurements, which constitutes the following, (1) Dermal Resurfacing with an adhesive
composition, (2) Dermal Polishing with a polishing composition, and (3) Dermal Regeneration with
a collagen-building and cell-proliferative composition.
Materials and methods for near-infrared and infrared lymph node mapping
A lymphatic system can be imaged with emissive semiconductor nanocrystals, for example, in the
near infrared.
Cosmetic and dermopharmaceutical compositions for skin prone to acne
The invention relates to the use of an extract of olive leaves (Olea europaea) which is titrated in
oleanolic acid and which may or may not be associated with a Larrea divaricata extract which is
titrated in nordihydroguaiaretic acid (NDGA). Said products are intended for all types of cosmetic
and dermopharmaceutical compositions for all forms of skin care, for moisturizing and antiinflammatory purposes and, in particular, for the prevention and treatment of skin prone to acne.
Silver salts of sucrose-octasulphate
The described invention relates to the new compound "sucrose-octasulphate salified with silver"
usefully applicable in the prevention and cure of infections by micro-organisms of bacterial, fungal,
viral and/or yeast origins and in the promotion of tissue repair. The silver salts of sucrose
octasulphate, subject of the invention have in fact been shown to possess antimicrobial activities
even higher than that of known silver compounds. These properties therefore make them
particularly suitable for use in different pathological or paraphysiological conditions of the skin, of
the epithelia and of the mucosa both intact and lesioned.
Optically clear nanocomposites and products using nanoscale fillers
Methods for preparing nanocomposites that enable films with optical clarity, wear resistance and
superior functional performance. Nanofillers and a substance having a polymer are mixed. Both
low-loaded and highly-loaded nanocomposites are included. Nanocomposite films may be coated
on substrates.
Method and apparatus for improving safety during exposure to a monochromatic light source
A method and apparatus are disclosed for improving bodily safety during exposure to an eye
hazardous monochromatic treatment light source by diverging the light, such as with a diffusing
unit attached to the light source distal end so that the radiance of the light exiting the distal end is
an eye safe level. At a first position of the light source distal end substantially in contact with an
outer surface of a target, the energy density of an exit beam from the distal end is suitable for
effecting a desired treatment, and at a second non-contact position of the distal end the exit beam
energy density is significantly less than a value suitable for effecting the treatment. In an additional
embodiment, the diverging or diffusing unit has a device for evacuating vapors or particles from the
target.
compound comprising an acid functional group and processes therefor
The present disclosure relates to compositions comprising at least one soluble fluorescent dye and
at least one compound comprising an acid functional group, and to processes using this
composition.It likewise relates to a method of using compositions comprising, in a cosmetically
acceptable medium, at least one soluble fluorescent dye and at least one compound comprising an
acid functional group for dyeing human keratin materials, such as artificially dyed and/or
Composition for dyeing human keratin materials, comprising a fluorescent dye and a particular
sequestering agent, process therefor and use thereof
The invention relates to a composition comprising at least one fluorescent dye and at least one
particular sequestering agent, and also to processes and a device for using these compositions.The
invention similarly relates to the use of a composition comprising at least one particular fluorescent
dye and at least one particular sequestering agent, to dye with a lightening effect human keratin
materials and more particularly artificially dyed or pigmented hair, and colored skin.
Cosmetic composition for dyeing human keratin materials, comprising at least one fluorescent dye and at
least one cationic polymer, and a dyeing process therefor
The present disclosure relates to a cosmetic composition comprising at least one fluorescent dye
comprising at least one fluorescent compound, and at least one cationic polymer with a charge
density of at least 1 meq/g; processes that incorporate this cosmetic composition and to a kit
comprising this cosmetic composition. The present disclosure also relates to the process for dyeing
human keratin materials, including artificially dyed or pigmented hair and dark skin, with a
lightening effect, comprising applying to the keratin materials a cosmetic composition comprising
at least one fluorescent dye comprising at least one fluorescent compound and at least one cationic
polymer with a charge density of at least 1 meq/g.
Nanotube based sunscreen
This invention relates generally to the incorporation of carbon nanotubes into compositions for
protection against damage from ultraviolet radiation. In particular, the invention is directed to
sunscreen compositions and methods for the preparation of sunscreen compositions.
Method and apparatus for a multi-use body fluid sampling device with analyte sensing
A device for use with a penetrating member driver to penetrate tissue is provided. A plurality of
penetrating members are coupled to a single cartridge and are operatively couplable to the
penetrating member driver. The penetrating members are movable to extend radially outward from
the cartridge to penetrate tissue. A plurality of analyte sensors are coupled to the single cartridge
and are positioned on the cartridge to receive body fluid from a wound in the tissue created by the
penetrating member.
Method of dyeing human keratin materials with a lightening effect with compositions comprising at least
one fluorescent dye and at least one amphoteric or nonionic surfactant, composition thereof, process
thereof, and device therefor
The present disclosure relates to a method of dyeing human keratin materials with a lightening
effect with a composition comprising, in a cosmetically acceptable medium, at least one fluorescent
dye that is soluble in the cosmetically acceptable medium and at least one surfactant chosen from
amphoteric surfactants and nonionic surfactants.The present disclosure also relates to compositions
comprising at least one particular fluorescent dye that is soluble in the cosmetically acceptable
medium and at least one surfactant chosen from amphoteric surfactants and nonionic surfactants,
and also to processes using these compositions, and devices for these compositions.
Treatment of ungual and subungual diseases
The treatment of ungual and subungual diseases is disclosed.
Flame retardant and smoke suppressant composite high performance support-separators and conduit
tubes
The present invention includes a high performance communications cable exhibiting reduced crosstalk of any form between transmission media that includes one or more core support-separators
having various shaped profiles which define a clearance to maintain a spacing between
transmission media or transmission media pairs. The core may be formed of a conductive or
insulative material to further reduce cross-talk and improve other electrical properties as well as
reduce flame and smoke spread. The cable and separators are comprised of principally polymer
blends that include olefin and/or fluoropolymer and/or chlorofluoropolymer based resins with and
without inorganic additive such as nano-clay composites. These unique blends offer both flame and
smoke suppression while maintaining the characteristics necessary to improve electrical
performance and allow for severe cost reduction over conventional separators. The specially shaped
core support-separators can be either interior to the cable jacket or be employed singularly without
the benefit of a jacket and extend along the longitudinal length of the communications cable.
Alternatively, with no jacket for cable completion, a portion of the separator wherein a thin layer of
material can act as a type of skin for future mechanical protection is provided. The specially shaped
core support-separator has both a central region as well as a plurality of shaped sections that extend
outward from the central region that are either solid or partially solid, foamed or foamed with a
solid skin surface. In addition, the invention includes the optional incorporation of hollow ducts
that can be used to provide optical or metal conductor media either before, during, or after
installation of the cable primarily by gas driven means.
polyol, process therefor and use thereof
Disclosed herein are compositions comprising at least one fluorescent dye and at least one polyol,
processes using this composition and a device therefor. Further disclosed herein is the use of a
composition for dyeing a human keratin material, such as artificially dyed or pigmented hair and
dark skin, with a lightening effect, comprising at least one fluorescent dye and at least one polyol.
associative polymer, process therefor and use thereof
Disclosed herein are compositions comprising at least one fluorescent dye and at least one
particular associative polymer, processes using this composition, and a device therefor. Further
disclosed herein is the use of a composition comprising at least one fluorescent dye and at least one
particular associative polymer for dyeing a human keratin material, such as artificially dyed or
Indanylidene compounds
Novel indanylidene compounds can be used as UV-A filters in cosmetic compositions for
protecting skin and hair and for technical applications.
Fibrous structures comprising a nonoparticle additive
Fibrous structures having an additive, more particularly finished fibrous structures having a
nanoparticle solid additive, and/or sanitary tissue products including such finished fibrous
structures, are provided.
Multi component controlled delivery system for soap bars
The present invention relates to an improved controlled delivery system that can be incorporated in
soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier
system also provides controlled release or prolonged release of these actives from the skin over an
extended period of time. The controlled delivery system of the present invention comprises
substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of
encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high
cationic charge density of the nanosphere improves deposition of active ingredients onto skin. The
high cationic charge density on the nanosphere surface is created by incorporating a cationic
conditioning agent into the solid hydrophobic matrix of the nanospheres, by incorporating a
cationic charge "booster" in the moisture sensitive microsphere matrix, or by using a cationic
conditioning agent in the nanosphere matrix in conjunction with a cationic charge "booster" in the
microsphere matrix. The invention also pertains to soap products comprising the controlled release
system of the present invention.
Hair treatment method
A hair treatment device includes a generator of electromagnetic radiation and optical guide
components operatively connected to the generator so as to direct electromagnetic radiation from
the generator away from entering a skin surface and in a direction substantially parallel to the skin
surface, to impinge on hair fibers protruding from the skin surface. A control unit is connected to
the generator for controlling the generator to produce the electromagnetic radiation in bursts of
light pulses each having a predetermined number of pulses of light for treating the hair fibers
protruding from the skin surface.
Photoprotective cosmetic compositions comprising para-aminobenzalmalonate-substituted s-triazine
compounds
Cosmetic/dermatological sunscreen compositions, suited for photoprotecting, e.g., the skin, lips,
scalp and/or hair against the damaging effects of UV-radiation, contain thus effective amounts of at
least one novel s-triazine compound tri-substituted with para-aminobenzalmalonate substituents.
Pharmacological activities of Curcuma longa extracts
This invention concerns to a topical pharmaceutical composition comprising an water soluble
Curcuma extract, and suitable excipients for said topical administration; the process for obtaining
said pharmaceutical compositions; the use of different Curcuma extracts as photosensitizing agents
for the treatment of proliferative diseases; and the use of Curcuma extract or curcuminoids in
combination with a radiation for the treatment of proliferative diseases on eukaryote cells.
Cosmetic compositions comprising at least one silicone copolymer and at least one additional silicone, and
uses thereof
Cosmetic compositions comprising, in a cosmetically acceptable medium, at least one silicone
copolymer with a dynamic viscosity ranging from 1.times.10.sup.6 to 100.times.10.sup.6 cP and at
least one additional silicone. This combination can give cosmetic properties, such as at least one of
smoothness, lightness, and softness, without the phenomenon of regressing keratin fibers. These
compositions can be used for washing and/or conditioning a keratin material, such as the hair or the
skin.
System, apparatus and method for inferring glucose levels within the peritoneum with implantable
sensors
A glucose sensor assembly useful in patient systems includes an oxygen sensor from which glucose
levels in the vicinity of the peritoneal cavity may be inferred. The sensor assembly may be
associated with electronics, such as any or all of a DC power supply, an LED source of blue light, a
photoreceptor for red light, a CPU, and transceiver, by a direct percutaneous connection.
Alternatively they may be associated transdermally with the sensor and some of the electronics
being located subdurally. Insulin infusion means are contemplated to respond manually or
mechanically to information from the sensors through the CPU. Mechanical response may be
automatic. Infusion means may be located subdurally. It is contemplated that the present invention
enable revitalization or replacement of fluorescing compounds and glucose oxidase within the
sensor assembly.
Diarylbutadiene-substituted methyltrialkylsilanes and photoprotective compositions comprised thereof
Novel 4,4-diarylbutadiene-substituted methyltrialkylsilanes having the structural formula (I):
##STR00001## are useful sunscreens for UV-photoprotecting human skin against the damaging
effects of UV-radiation, notably UV-A radiation.
Diarylbutadiene-substituted diorganopolysiloxanes and photoprotective compositions comprised thereof
Novel 4,4-diarylbutadiene-substituted diorganopolysiloxanes having the structural formulae (1) or
(2): ##STR00001## in which A is a radical of formula (3) below: ##STR00002## are useful
sunscreens for UV-photoprotecting human skin against the damaging effects of UV-radiation,
notably UV-A radiation.
Hybrid natural-fiber composites with cellular skeletal structures
The present invention relates to composite structural members comprising polymers, natural and
synthetic fibers, and nano-scale platelets arranged in two- or three-dimensional cellular skeletal
structure; more particularly referring to a low-cost natural-fiber based structural member with
material hybridization and material layout for improved behavior that leads to efficient structural
beam and plate/panel components that can be used in a plurality of modular structures, resulting in
lower cost and reduced environmental impact.
Polymeric nanofibers for tissue engineering and drug delivery
Polymeric nanofibers have been developed which are useful in a variety of medical and other
applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound
dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These
can be formed of any of a variety of different polymers, either non-degradable or degradable. In a
preferred embodiment demonstrated in the following examples, nanofibers are formed of
biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes
or with organic, inorganic/organometallic polymers as well as composite nanofibers of
polyphosphazenes with nanosized particles such as hydroxyapatites.
Method for making devices using polyhydroxyalkanoate having pyrogen removed
Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in
numerous biomedical applications. PHAs which have been chemically modified to enhance
physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the
reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers
prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed
from the polymers without adversely impacting the polymers' inherent chemical structures and
physical properties. PHAs with advantageous processing characteristics, including low melting
points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are
suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and
other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug
delivery, and for diagnostic and prophylactic uses. Properties which are selected for include
degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be
used to attach targeting agents, and bioadhesion.
Dye composition comprising at least one fluorescent dye and a non-associative thickening polymer for
human keratin materials, process therefor, and method thereof
The disclosure relates to a composition comprising at least one fluorescent dye and at least one
non-associative thickening polymer, to processes using such a composition, and to devices
comprising such a composition.The disclosure also relates to processes and methods for dyeing
human keratin materials, for example artificially dyed or pigmented hair and dark skin, with a
lightening effect, using compositions comprising at least one fluorescent dye and at least one nonassociative thickening polymer.
acrylonitrile
cosmetically acceptable support, at least one compound of formula (1) or (2) ##STR00001## in
which X.sub.1 represents R.sub.3--(C.dbd.O)--, R.sub.3--SO.sub.2-- or R.sub.3--O--(C.dbd.O)--,
X.sub.2 represents --(C.dbd.O)--R'.sub.3--(C.dbd.O), --SO.sub.2--R'.sub.3--SO.sub.2-- or -(C.dbd.O)--O--R'.sub.3--O--(C.dbd.O)--, Y represents --(C.dbd.O)--R.sub.4 or --SO.sub.2R.sub.5,
Hair restoration device and methods of using and manufacturing the same
The present invention provides for a hair restoration device and methods of manufacturing and
using the same. In one embodiment, the hair restoration device is comprised of (i) a hairbrush body
housing a plurality of wide-pattern laser LEDs configured to cooperate to project a precision laser
light pattern at a focal plane proximate a skin area to be irradiated; and (ii) bristles extending from
the hairbrush body and terminating substantially at the focal plane.
Electrospray and enhanced electrospray deposition of thin films on semiconductor substrates
A method of forming a thin film on a substrate to fabricate a microelectronic device, a
microelectronic device comprising a thin film deposited according to the method, and a system
comprising the microelectronic device. The thin film may include on of a low k thin film, a thin
film comprising photoresist, and a sacrificial polymer. The method comprises dispersing a
precursor preparation into a spray of charged droplets through subjecting the liquid precursor
preparation to electrostatic forces; directing the charged droplets to move toward the substrate; and
allowing the charged droplets to generate a beam of gas-phase ions as the charged droplets move
toward the substrate. The method further includes directing the gas-phase ions to impinge upon the
substrate to deposit the thin film thereon to yield a deposited thin film on the substrate.
System for treatment of acne skin condition using a narrow band light source
The acne treatment devices use an array of LEDs, which emit monochromatic light substantially at
a wavelength of 405 nanometers, which is coincident with the peak absorbance of light by acne
porphyrins. The emitted light is directed from the light source to an acne area of the skin. The
device can either be hand-held, with the LEDs mounted on a handle portion, or an LED can be
mounted on a patch-like mounting element, which is adapted to be secured to the skin for longer
exposure at less intensity.
Treatment of skin disorders with UV light and cooling
Skin disorders such as, for example, atopic dermatitis, dyshidrosis, eczema, lichen planus,
psoriasis, and vitiligo, are treated by applying high doses of ultraviolet light to diseased regions of a
patient's skin. The dosage exceeds 1 MED, as determined for the particular patient and may range
from about 1 MED to about 20 MED or higher. The ultraviolet light has a wavelength within the
range of about 295 nanometers to about 320 nanometers. High doses of ultraviolet light are
restricted to diseased tissue areas The skin can be cooled prior to and/or during exposure to UV
light to minimize tissue damage resulting from exposure to the UV light. Higher doses of UV light
can therefore be employed without injurious affects.
Method and apparatus for monitoring and controlling laser-induced tissue treatment
The present invention provides methods and apparatus for controlling light-induced tissue
treatment. In accordance with various aspects of the present invention, the invention provides for
improved, real-time control of the light beam operational parameters which enables greater safety,
efficiency, uniformity and continuity of the treatment process.
Photoprotecting/cosmetic compositions comprising benzotriazole and bis-resorcinyltriazine
Topically applicable sunscreen/cosmetic compositions suited for the improved photoprotection of
human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation,
comprise an effective SPF-maintaining and water remanence-enhancing amount of intimate
admixture of (a) at least one benzotriazole first sunscreen compound and (b) at least one bisresorcinyltriazine second sunscreen compound, formulated into (c) a topically applicable,
Medical device for analyte monitoring and drug delivery
The invention relates to an ingestible, implantable or wearable medical device comprising a
microarray which comprises a bioactive agent capable of interacting with a disease marker
biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of
releasing the therapeutic agent(s) from the medical device; and a plurality of microchips
comprising a microarray scanning device capable of obtaining physical parameter data of an
interaction between the disease marker biological analyte with the bioactive agent; a biometric
recognition device capable of comparing the physical parameter data with an analyte interaction
profile; optionally a therapeutic agent releasing device capable of controlling release of the
therapeutic agent from the reservoirs; an interface device capable of facilitating communications
between the microarray scanning device, biometric recognition device and the therapeutic agent
releasing device; and an energy source to power the medical device. Specifically, the invention
relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one
microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the
sample flows and is in fluid communication with the at least one microneedle, a second
microchannel in fluid communication with the first microchannel, through which a buffer flows,
wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning
device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and
an interface device.
Method for controlling thickness of skin layer of composite resin molded product
To control the thickness of the skin layer of a composite resin molded product by a viscosity
difference obtained by varying the viscosity by adding another ultra-minute substance to a raw
resin material.The composite resin molded product comprising the skin layer formed of a first
thermoplastic resin and the core layer formed of a second thermoplastic resin is molded by
injection. The viscosity difference between the resins is controlled by adding a carbon nanomaterial
to one or the other of the thermoplastic resins. The thickness of the skin layer is controlled by the
viscosity difference. The first thermoplastic resin and the second thermoplastic resin are of the
same kind or different kinds of resins.
nanodiamond to bond with biological materials and to improve mechanical strength.
Nanodiamonds can be dispersed in a biologically acceptable carrier to form various nanodiamond
compositions. The presence of nanodiamonds can increase binding with many biological materials,
making the compositions of the present invention useful for a large variety of purposes such as
cleansing, testing and identification of materials, and treatment of adverse conditions. Specific
examples of nanodiamond compositions that can be formulated include deodorants, toothpastes,
shampoos, antibiotics, dermal strips, DNA test strips, skin cleansers, and the like. Similarly,
nanodiamond particles can be included in a cosmetic nanodiamond composition within a
cosmetically acceptable carrier. Cosmetic nanodiamond compositions can include, for example,
nail polish, eyeliner, lip gloss, exfoliant, and the like.
Cosmetic and cosmeceutical compositions for restoration of skin barrier function
Long lasting waterproof sunscreen comprising metal oxide and peptide conditioner
The disclosure provides a sunscreen formulation comprising a peptide-based metal oxide sunscreen
agent, such as titanium dioxide nanoparticles, and a fluid vehicle.
Vitamin D analogues
Novel biaromatic vitamin D analogues have the general formula (I): ##STR00001## and are suited
for a wide variety of pharmaceutical applications, whether in human or veterinary medicine, and
also for cosmetic applications.
Phase inverted oil-in-water photoprotective emulsions comprising nanopigments of metal oxides and 4,4diarylbutadiene UV-A sunscreens
Stable UV-photoprotective, phase inverted oil-in-water emulsions, well suited for the
photoprotection of the skin, lips and/or hair, the average size of the globules which constitute the
oily phase thereof ranging from 100 nm to 1,000 nm, contain inorganic metal oxide nanopigments
and at least one organic UV-screening agent, and which also contain at least one organic 4,4diarylbutadiene UV-A-screening agent.
Aqueous photoprotective compositions comprising diblock or triblock copolymers and 4,4diarylbutadiene UV-A sunscreens
at least one aqueous phase, at least one water-soluble or water-dispersible polymer having a diblock
structure A-B or a triblock structure B-A-B wherein A is an ionic water-soluble polymeric block
and B is a hydrophobic polymeric block and at least one system screening out UV radiation, said at
least one screening system comprising at least one 4,4-diarylbutadiene UV-A screening agent.
Antiaging cosmetic delivery systems
The present invention provides a comprehensive solution to the problems associated with natural
topical aging via the incorporation of: (i) An Extra-cellular antioxidant or Free-radical neutralizing
composition, and (ii) An Intra-cellular antioxidant or Free-radical neutralizing composition, and
(iii) An Anti-inflammatory composition, and (iv) A collagen or fibrin boosting composition. It is
preferred to also have the above incorporated in a suitable carrier base or topical delivery system
for skin, nail, and hair beneficial applications.
Amine, amide, sulphonamide and carbamate derivatives of benzalmalonic salts and photoprotective
cosmetic compositions comprised thereof
Stable, topically applicable cosmetic/dermatological sunscreen compositions, well suited for the
UV-photoprotection of human skin/keratinous materials, contain a thus effective amount of at least
one novel amine, amide, sulphonamide or carbamate substituted benzalmalonic salt compound.
Ligand inhibitors of the RAR receptors, process for preparing same and therapeutic/cosmetic
applications thereof
Novel bicyclic compounds having the structural formula (I): ##STR00001## are useful in a variety
of pharmaceutical applications, whether human or veterinary, and also in cosmetics.
Laser therapy device for animals and methods of using the same and manufacturing the same
The present invention provides for a laser therapy device for animals and methods of
manufacturing and using the same. In one embodiment, the animal therapy device is comprised of
(i) a hairbrush body housing a plurality of wide-pattern laser LEDs configured to cooperate to
project a precision laser light pattern at a focal plane proximate an area to be irradiated; and (ii)
bristles extending from the hairbrush body and terminating substantially at the focal plane. Laser
light is used to treat different portions of the animal body.
Thermal surgical procedures and compositions
Methods, compositions, and systems useful to enhance a thermal surgical procedure are described.
Compositions include at least one compound effective to induce an inflammatory response in
biological material identified to undergo a thermal surgical procedure. Methods and systems
include providing compositions of the invention to biological materials and treating biological
materials with an inflammation inducing composition for a time, amount, and type effective to
induce inflammation in at least a portion of the biological material.
Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof
Novel ligand antagonists of the RAR receptors have the following structural formula (I):
##STR00001## in which A is a CH.sub.2, CHOH, C.dbd.O or C.dbd.N--OH radical or a sulfur or
selenium atom; B is a radical selected from among those of formulae (a) to (f): ##STR00002## and
Ar is a radical selected from among those of formulae (g) to (i): ##STR00003##
Synthetic roofing shingle or tile
A synthetic roofing shingle or tile is provided, in which a core material is formed, of generally less
expensive material, and with a skin material provided, disposed on a plurality of surfaces of the
shingle or tile, with the skin material being generally of greater expense and having desirable
weather-withstanding qualities.
Photoprotective compositions comprising methyltrialkylsilanes containing a cinnamate, cinnamamide,
benzalmalonamide or benzalmalonate function
Unique photoprotective compositions contain novel methyltrialkylsilanes bearing a cinnamate,
cinnamamide, benzalmalonamide or benzalmalonate function, useful as sunscreens that are active
in the field of UV radiation.
Molecules derived from noraporphine
Photostable photoprotective compositions comprising dibenzoylmethane and arylalkyl benzoate
sunscreen and an effective photostabilizing amount of (ii) at least one arylalkyl benzoate compound
and (iii) at least one compound accepting the excited triplet level energy of said at least one
dibenzoylmethane sunscreen, formulated into (iv) a topically applicable,
Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a
compound that accepts the excited triplet level energy of said dibenzoylmethane(s)
sunscreen and an effective photostabilizing amount of (ii) at least one oil containing at least one
amide structural unit and (iii) at least one compound accepting the excited triplet level energy of
said at least one dibenzoylmethane sunscreen, formulated into (iv) a topically applicable,
Topical treatment for dyshidrosis (pompholyx) and dry skin disorders
A topical herbal formulation for preventing and/or treating dyshidrosis (pompholyx), nonresponsive to topical steroids. The formulation may also be used to treat contact dermatitis, eczema,
palmoplantar pustulosis and skin infections incurred by invasive pathogens such as mold, fungus
and bacteria. The formulation is comprised of plant extracts and niacin, that when combined yield
an effective multi-faceted pharmaceutical approach to treating dry skin disorders. The active
ingredients within the formula include a combination of dry, aqueous, acid and alcohol extracts of
black walnut hull (Juglans Nigra), wormwood (Artemisia Absinthium), tumeric rhizome (Curcuma
Longa), garlic (Allium sativum), chamomile (Matricaria Chamomile), licorice root (Glycyrrhiza
Glabra), St Johns wort (Hypericum perforatum), aloe vera, niacin and herbal anti-bacterial agents.
Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds/amidebased oils and photoprotective compositions comprised thereof
The present invention relates to a process for photostabilizing, with respect to UV radiation, at least
one dibenzoylmethane derivative with at least one arylalkyl benzoate derivative and at least one oil
containing in its structure at least one amide unit.Another subject of the invention also relates to a
novel cosmetic or dermatological composition for topical use, characterized in that it comprises, in
a cosmetically acceptable support: (a) at least one UV-screening agent of the dibenzoylmethane
derivative type and (b) at least one arylalkyl benzoate derivative and (c) at least one oil containing
in its structure at least one amide unit.The present invention also relates to the use of an arylalkyl
benzoate derivative and an oil containing in its structure at least one amide unit in a cosmetic or
dermatological composition comprising at least one dibenzoylmethane derivative, for the purpose
of improving the stability with respect to UV rays of the said dibenzoylmethane derivative.
Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds and
photoprotective cosmetic compositions comprised thereof
Topically applicable cosmetic/dermatological photoprotective compositions contain at least one
dibenzoylmethane UV-screening agent, and, as a photostabilizer therefor, at least one arylalkyl
benzoate compound of formula (I) or (II) below: ##STR00001## with the proviso that: (i) the
subject compositions are characteristically devoid of any octyl methoxycinnamate; and (ii) same
are other than a solution of butyl methoxydibenzoylmethane in 2-phenylethyl benzoate, 2phenylethyl o-toluate, 2-phenylethyl p-toluate or in a 2-phenylethyl o-toluate/2-phenylethyl ptoluate (1/1) mixture.
Vision enhancement system for improved detection of epithelial neoplasia and other conditions
Systems and methods for diagnosing epithelial neoplasia and other conditions includes, in a
representative embodiment, providing the human eyes with a filter to observe the autofluorescence
of a tissue sample. Using optimized wavelengths from a filtered light source, a sample is
illuminated. The radiation from the sample is filtered to enhance the contrast between a normal
sample and a diseased sample observable by the human eye.
Methods of enhancing radiation effects with metal nanoparticles
The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to
enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of
ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously,
intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal
nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to
the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or
cells ex vivo.
Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate/bis-resorcinyl
triazine compounds and photoprotective compositions comprised thereof
Topically applicable, photostable compositions with respect to UV radiation contain at least one
dibenzoylmethane UV-screening agent and at least one arylalkyl benzoate compound and at least
one bis-resorcinyl triazine compound.
Finely divided photoprotective oil-in-water emulsions comprising 4,4-diarylbutadiene UV-A sunscreens
UV-Photoprotective oil-in-water emulsions well suited for photoprotecting the skin, lips and/or hair
against the damaging effects of UV-radiation, the oil globules of which having an average size of at
most 500 nm and containing particles of at least one ionic polymer and at least one UV-radiationscreening system, such screening system comprising at least one 4,4-diarylbutadiene UV-Ascreening agent.
Method, system and module for monitoring a power generating system
active material.
Sunscreen compositions comprising metal oxide mineral pigments and hydroxyalkylurea compounds
The invention relates to a composition comprising, in a cosmetically acceptable carrier, a system
for screening out UV radiation, characterized in that it contains:(a) at least metal oxide-based
mineral pigments, and(b) at least one hydroxyalkylurea of formula (I) below: ##STR00001## in
which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently represent a hydrogen atom, a
C.sub.1-C.sub.4 alkyl group or a C.sub.2-C.sub.6 hydroxy-alkyl group that may contain from 1 to 5
hydroxyl groups, at least one of the radicals R.sub.1-R.sub.4 representing a hydroxyalkyl group,
and also a salt, solvate or isomer thereof, said composition containing no kojic dipalmitate.The
invention also relates to the use of a hydroxyalkylurea of formula (I) in a composition comprising,
in a cosmetically acceptable carrier, at least metal oxide-based mineral pigments, for reducing, or
even eliminating, the whitening effect on the keratin material after application.
Co-extruded biaxially oriented sealable, peelable film and process for its production
A peelable sealable co-extruded film, comprising: i. a skin layer capable of heat sealing against a
rim of a container, to itself, or to another film and adapted to be peeled there from and comprising a
hot melt adhesive resin; and ii. a core layer underlying said skin layer and comprising crystalline
homopolymer polyethylene terephthalate; and a method for the preparation thereof.
Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine
sunscreen and an effective photostabilizing amount of (ii) at least one bis-resorcinyl triazine
compound and (iii) at least one compound accepting the excited triplet level energy of said at least
one dibenzoylmethane sunscreen, notably at least one 4-hydroxybenzylidenemalonate compound,
4-hydroxycinnamate compound, fluorene compound, piperidinol salt, or mixture thereof,
formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support
therefor.
Absorption and bioavailability of carotenoids, formulations and applications
A process for obtaining a microscopic physical state of xanthophylls or oxycarotenoids derivatives
forms such as diacetates or dipropionates derivatives, which are readily incorporated in the
digestive system as micelles providing an improved bioavailability, as compared to the
bioavailability of carotenoids that are ingested in diverse preparations that contain microscopic
carotenoids crystals and a method for its application.
Beauty wash product compositions delivering enhanced visual benefits to the skin with specific optical
attributes
The present invention relates to compositions delivering enhanced visual benefits to the skin with
specific optical attributes. These are delivered using specific deposition systems (where
oil/emollient comprises part of deposition system) and/or by ensuring dispersion of particles.
Nanoparticles for protein/peptide delivery and delivery means
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile
bombardment as a carrier for administering proteins or peptides to an animal subject. The
nanoparticles are composed of positively charged shell substrate, negatively charged core substrate
with encapsulated bioactive agents of proteins or peptides.
Antenna constructions for electronic devices and methods for manufacturing such antenna constructions
Antenna constructions for electronic devices and methods of manufacturing such antenna
constructions. The electronic device comprises a transponder and an antenna electrically coupled
with the transponder. The antenna has a core of a first material and a coating of a second material
on the core. The second material has a higher electrical conductivity than the first material and/or a
lower permeability than the first material. The coating on the core also has a predetermined
thickness. The electronic devices may be used in tires.
Nanoparticulate compositions having lysozyme as a surface stabilizer
The present invention is directed to nanoparticulate active agent compositions comprising
lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical
compositions comprising a nanoparticulate active agent composition of the invention and methods
of making and using such nanoparticulate and pharmaceutical compositions.
Conductive resin molded product having insulating skin and method for forming the same
The present invention relates to a conductive resin molded product having an insulating skin
produced by a composite comprising a non-conductive resin and conductive material. The
invention also provides a method for producing the conductive resin molded product.
Nano-silver wound dressing
A nano-silver wound dressing consisting of a skin contact layer made from hydrophilic cloth and
directly contacting a wound on the surface of the skin, a disinfecting (or bactericidal) antitoxic
layer made from activated charcoal cloth impregnated with nanocrystalline silver, a blood
absorbing and styptic layer made from a superabsorbent polymer non-woven cloth, an isolation
layer made from a composite fabric with a pore size of less than 5 .mu.m, and an elastic bandage
for fixing a main body on the site of wound. Edges of the isolation layer and the skin contact layer
are integrated to form a main body while the disinfecting (or bactericidal) antitoxic layer as well as
the blood absorbing and styptic layer are separated from each other and both enclosed inside the
main body.
Concentric-eccentric high performance, multi-media communications cables and cable supportseparators utilizing roll-up designs
The present invention includes a high performance communications cable or cable supportseparator and/or jacket and includes one or more core support-separators having various shaped
profiles. The core may be formed of conductive or insulative material and may be comprised of
polymer blends that include olefin and/or fluoropolymer and/or chlorofluoropolymer based resins
with or without inorganic additives such as nano-clay composites, C.sub.60 based compounds, etc.
The core support-separator has both a central region as well as a plurality of shaped sections that
extend outward from the central region that are either solid or partially solid, foamed or foamed
with a solid skin surface. The invention includes incorporation of hollow ducts that can be used to
provide for insertion of optical or metal transmission media either before, during, or after
installation of the cable.
Skin treatment preparation
A skin treatment preparation including carriers, a medicinal vector encapsulating a plant extract
(Cucumis melo protein extract) rich in reductase, catalase and superoxide dismutase is
characterized in that the medicinal vector, of nanospheres, represents 1 to 20 wt. % of the weight of
the preparation; and the encapsulated plant extract represents 5 to 15 wt. % of the weight of the
nanospheres; and the encapsulated plant extract may have the following enzymatic concentrations:
reductase between 100 and 1000 IU, catalase between 100 and 1000 IU, and superoxide dismutase
between 500 and 5000 IU. The preparation is useful for limiting depigmentation and reducing
inflammatory front in vilitigo pathology and possible repigmentation.
Infrared face detection and recognition system
A face detection and recognition system having several arrays imaging a scene at different bands of
the infrared spectrum. The system may use weighted subtracting and thresholding to distinguish
human skin in a sensed image. A feature selector may locate a face in the image. The face may be
framed or the image cropped with a frame or border to incorporate essentially only the face. The
border may be superimposed on an image direct from an imaging array. A sub-image containing
the face may be extracted from within the border and compared with a database of face information
to attain recognition of the face. A level of recognition of the face may be established. Infrared
lighting may be used as needed to illuminate the scene.
US Patent No: RE38681
Method for non-invasive wrinkle removal and skin treatment
A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the
epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light
communication with a pulsed dye laser delivery device. The pulsed dye laser delivery device is
applied against tissue having wrinkles. The pulsed dye laser generator generates a pulsed dye laser
light. A pulsed dye laser light from the pulsed dye laser delivery device is directed onto the tissue,
to reach hemoglobin in a collagen layer up to about 1.2 mm. beneath the surface of the tissue to
effect growth changes therein.

Progress on - FormulaScan

Transcription

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