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Table of Contents
Information
Table of Contents
Information
4
Venue Map
4
Welcome Address5
Acknowledgements8
Sponsors
9
Host & Organising Committees12
General Information14
Social Programme19
Business Meetings21
Scientific Programme Overview
22
Sunday, September 1st26
Monday, September 2nd33
Tuesday, September 3rd46
Wednesday, September 4th56
Sponsor / Exhibitor-hosted Sessions
Posters
62
67
Author Index125
Exhibitors Booth
151
Exhibitors151
Exhibitors Booth Map179
Eurotox Congress Awards
180
3
Information
Venue Map
BRÜNIG 1–3
AUDITORIUM
FIRST FLOOR
CONGRESS HALL
THEATRE ROOM
COVERED
PARKING
RONDELL
CLUB CASINO
SPYCHER
BALL
ROOM
CONCERT HALL
GROUND
FLOOR
RUGEN
HARDER 1
HARDER 2
GRIMSEL 1
GRIMSEL 2
SUSTEN
4
Information
Welcome Address
Dear Colleagues and Friends,
On behalf of EUROTOX and the Swiss Society of Toxicology, it is our
privilege and honour to welcome you to the 49th EUROTOX Congress in
Interlaken.
The EUROTOX meeting offers a unique opportunity for toxicologists
with different backgrounds, coming from a variety of countries, to
meet and network with friends, colleagues and leaders in the different
disciplines.
Thomas Weiser
We are proud to present a scientific programme created with input
from toxicologists from all parts of Europe. This congress under the
theme: “New Frontiers in Safety Sciences” represents our discipline’s
novel scientific and regulatory discoveries in symposia and workshops
framed by key note lectures, continuing education courses and poster
sessions.
In addition, please take advantage of communication, discussion and information exchange with the representatives at the business exhibition.
Interlaken is nicely situated in the heart of Switzerland between the
lakes of Brienz and Thun and at the foot of the famous Swiss Alps trio
known as the Eiger, Moench and Jungfrau offering spectacular views
from ‘Jungfraujoch – Top of Europe’. The Congress Centre is centrally
located in the small city of Interlaken with hotels, restaurants, shops
and cultural attractions all within walking distance.
We have organized for a very attractive social programme and a multitude of activities to explore the breathtaking area around Interlaken
with its many attractions.
We strongly hope that all this will make the EUROTOX 2013 Congress
an event for you to remember.
Thomas Weiser
DVM, PhD, DABT
Prof. Friedlieb Pfannkuch
MD
President of the EUROTOX 2013
Organizing Committee, Vice-President
of the Swiss Society of Toxicology
President of the
Swiss Society of Toxicology
5
Welcome Address
Dear Colleagues
On behalf of EUROTOX, the federation of European Societies of Toxicology, I extend a warm welcome to all participants in this 49th Congress of EUROTOX hosted by the Swiss Society of Toxicology. We are
delighted that so many of you have chosen to join us here in Interlaken,
between the lakes of Brienz and Thun and at the foot of the impressive
Jungfrau.
Ruth Roberts
The annual meeting of EUROTOX is an opportunity to showcase the
very best in novel science around mechanistic toxicology and its application to the health and welfare of humans, animals and our environment. With a theme of ‘New Frontiers in Safety Science’, this programme offers many opportunities for us all to come together and
learn in an atmosphere of exchange and collaboration.
Your participation in this congress will make it a unique and successful
event. Whether you are a speaker, a student, a postdoc, an organizer,
an exhibitor, a panelist, a session chair, a poster presenter or an expert
working in the field you will meet and share your knowledge and experience with colleagues from around the world within this rich environment for networking and building of future collaborations.
This 49th Congress features many important and relevant topics in the
field, covering the diverse fields of environmental, industrial, regulatory and clinical toxicology. With 18 workshops, 18 symposia and numerous poster sessions there is indeed plenty to interest everybody. We
are also featuring several short oral sessions selected from submitted
poster abstracts; these sessions give great opportunities for scientists
to present their work in a supportive environment.
6
Information
I would like to extend my special thanks to everybody who has contributed to this meeting via their tireless work, especially within the Scientific and Local Organizing Committees. In addition, I would like to extend my sincere thanks for the support we received with the scientific
sessions, with many excellent ideas coming from the National Societies, the individual members (IMs), Speciality Sections and the many International organisations such as ECHA, EFSA, EPA and HESI ILSI that
support our scientific mission. The quality and impact of our science
improves year on year thanks to the great ideas coming from you, the
membership.
I urge you to join us in Interlaken and bring your challenges, thoughts
and ideas to enrich our meeting. You will see that alongside the exciting scientific sessions, there are multiple social events for you to enjoy.
We hope you will return home with new friends, inspired by new ideas
and enthused with possibilities for collaborations. Please let us know if
there is anyway in which we can enrich your stay and we will endeavour
to address your needs.
Best regards
Ruth Roberts
PhD, FRCPath, ATS, FBTS, ERT
President of EUROTOX
7
Acknowledgements
The Local Organizing Committee of the EUROTOX 2013 Congress gratefully
acknowledges support:
Management of Roche Ltd., Pharma – Early Research and Development (pRED) for
generously supporting members of Non-Clinical Safety to contribute to the congress
organisation over many months. Our thanks particularly go to Thomas Singer, Senior
Vice President Global Non-Clinical Safety.
Management of Novartis Pharma Ltd. for generously supporting that staff members of
their Pre-Clinical Safety Department have contributed to the congress organisation over
many months. Substitutional for all of them we want to thank Page Bouchard, Vice
President at Novartis Institutes for BioMedical Research (NIBR).
For scientific review of poster abstract submissions, in addition to members of the local
Scientific Programme Committee: Rex FitzGerald, Andrea Greiter-Wilke, Heather
Hinton, Manfred Kansy and Marielle Odin.
Matthias Festag for supervision and organisation of the local support by students.
Angela Kuenzi for comprehensive administrative support and accounting services.
Front row: Elisabeth Rosner, Heinrich Urwyler, Ellen Paehler, Friedlieb Pfannkuch.
Back row: Martin Wilks, Michael Arand, Hans-Joerg Martus, Juerg Seiler.
8
Information
Sponsors
Platinum
European Centre for Ecotoxicology and
Toxicology of Chemicals
European Crop Protection Association
F. Hoffmann-La Roche Ltd.
Pharma Early Research and Development (pRED)
Gold
Novartis Institutes for BioMedical Research (NIBR)
Silver
9
Silver (continued)
Sanofi-Aventis Deutschland GmbH
Bronze
10
Information
Bundesamt für Gesundheit – BAG
Consumer Health
Novartis Consumer Health
Swiss Centre for Applied Ecoxicology – SCAET
(EAWAG Aquatic Research)
Institut de Recherches Internationales Servier
RCC India
Swiss Centre for Applied Human Toxicology – SCAHT
11
Host & Organising Committees
EUROTOX Executive Committee
Ruth Roberts, President
Nancy Claude, Past President
Aristidis Tsatsakis, President Elect
Felix Carvalho, Secretary-General
Werner Kobel, Treasurer
Nursen Basaran
Christina Rudén
Eva Bonefeld-Jorgensen,
Mojmir Mach
Swiss Society of Toxicology – Board
Friedlieb Pfannkuch, President
Thomas Weiser, Vice-President
Elisabeth Rosner, Secretary-General
Lothar Meister, Treasurer
Michael Arand
Martin Bopst
Pierre Crettaz
Ellen Paehler
Martin Wilks
Local Organising Committee – EUROTOX 2013
Thomas Weiser, President
Michael Arand, Poster Sessions
Hans-Joerg Martus, Sponsoring
Friedlieb Pfannkuch, Budgeting – Accounting
Elisabeth Rosner, Public Relations – Social Events
Juerg Seiler, Liaison with Congress Centre
Heinrich Urwyler, Exhibition
Martin Wilks, Continuing Education Courses
12
Information
Scientific Programme Committee – EUROTOX 2013
Ruth Roberts, EUROTOX President, Chair
Thomas Weiser, EUROTOX 2013 Local Scientific Programme Committee
Michael Arand, EUROTOX 2013 Local Scientific Programame Committee
Giuseppe Malinverno, EUROTOX Executive Committee Member
Dieter Schrenk, EUROTOX Carcinogenesis Speciality Section
David Bell, EUROTOX Risk Assessment Speciality Section
Raymond Pieters, EUROTOX Immunotoxicology & Chemical Allergy Speciality Section
Jean-Lou Dorne, EUROTOX Molecular Toxicology Speciality Section
Kevin Chipman, EUROTOX 2014 Congress representative
Local Scientific Programme Committee – EUROTOX 2013
Thomas Weiser, Chair
Michael Arand
Elisabeth Klenke
Jonathan Moggs
Francois Pognan
Benoit Schilter
Josef Schlatter
Jennifer Sims
Shana Sturla
Inge Werner
Continuing Education Courses – EUROTOX 2013
Martin Wilks, Chair
Lothar Aicher
Rex FitzGerald
Georg Geisler
Adrian B. Roth
13
General Information
Badges
The participant’s name badge will be provided at the registration desk. All participants
are required to wear the badge throughout the conference. Only badge holders will be
admitted to the sessions and the exhibition.
Banking Hours
Banks are generally open from Monday to Friday 09.00 – 12.00 and 13.30 – 17.00. There are
also many ATMs all over Interlaken where money can be withdrawn with credit cards.
Cellular Phones
Cellular phones must be switched off in the conference rooms.
Check-in/-out
Hotel check-in time is generally from 14.00 onwards and check-out time is usually 12.00.
Climate and Clothing
The climate in Interlaken at the beginning of September is generally mild, with average
temperatures during the day of about 16°C and maxima of about 20°C, while the nights
may already be rather cold. It is advisable to bring some light clothes for daytime and
some warm clothes for the evening. Clothing for all social events should be smart casual.
Coffee Breaks
Coffee and tea will be served during coffee breaks on Sunday in the Congress Hall and
from Monday to Wednesday in the Congress Hall and at the Food & Beverage areas of the
Concert Hall (Exhibition).
Credit Cards
Commonly accepted credit cards in hotels, restaurants and shops are American Express,
Diners Club, Visa and MasterCard. Restaurants and shops generally display signs indicating
what cards they accept. The registration desk accepts Visa and MasterCard, only.
Currency
The currency used in Switzerland is the Swiss Franc (CHF). Prices are usually also indicated
in Euros, and most stores, shops and restaurants accept Euros (change will be given in
Swiss Francs. The exchange rate will not be the official one, and it may be somewhat less
advantageous).
14
Information
Disabled Access and Special Assistance
Access for disabled persons is guaranteed, and special assistance can be provided upon
request.
Entry Formalities
Switzerland belongs to the European Schengen area and the corresponding requirements
apply. Participants needing a visa for entry to Switzerland are strongly advised to apply
to the Swiss Embassy or a Swiss Consulate in their home country well in advance. For
information on passport/visa requirements for entry into Switzerland, contact the Swiss
Embassy or Consulate in your country, or obtain the relevant information from your travel
agency. Should you need to apply for a visa, the congress organizers will – upon request –
send you a “Letter of Invitation” to support your application. Please note that such a letter
is not a commitment on the part of the conference to provide financial support.
Exhibition
Opening hours:
19.30 – 21.30
Sunday, September 1st:
Monday, September 2nd: 9.30 – 18.30
8.30 – 18.00
Tuesday, September 3rd:
Wednesday, September 4th:8.30 – 11.00
Health and Travel Insurance/Liability
Delegates are advised to take out appropriate health and travel insurance. Neither the
conference organisers nor the conference secretariat accept any liability for personal
injuries sustained, or for loss or damage to property belonging to conference participants,
either during or as a result of the conference or during all tours and events.
Internet Access
The Congress Centre is equipped with a Swisscom HotSpot for WLAN Internet Access.
Also, most hotels provide internet access via Ethernet and/or WLAN in the rooms, as well
as WLAN access in the lobby (see hotel descriptions for details).
Language
The official language of the congress is English. There will be no simultaneous translation.
Interlaken belongs to the German-speaking part of Switzerland, but people in stores,
restaurants and hotels are mostly fluent in English and French. Shop signs are also
frequently displayed in Japanese.
15
Local Transport
Upon arrival at your hotel you will receive a “Interlaken Guest Card” which will allow
unlimited free travel with public transport within the “Bödeli” area (i.e. within the
communities of Interlaken, Unterseen, Bönigen and Matten).
Lunches
Buffet lunches will be available in the Congress Hall on:
Sunday, September 1st: 12.00 – 13.00
Monday, September 2nd: 12.00 – 14.00
Tuesday, September 3rd: 12.00 – 13.30
On-Site Registration
On-site registrations will be possible. When registering on-site, however, participants
should be aware that the availability of accommodation (and possibilities for
participation in the social events) may be limited.
Poster Areas
Poster areas are located in 3 areas:
Monday, September 2nd, 2013
Auditorium Foyer: P01/01 – P03/14; P06/01 – P09/25; P11/01 – P11/16
Concert Hall:
P04-01 – P04/14; P10/01 – P10/24; P15/01 – P17/18
Club Casino:
P05/01 – P05/23
Tuesday, September 3rd, 2013
Auditorium Foyer: P12/01 – P14/28, P20/01 – P21/03
Concert Hall:
P18/01 – P18/27, P23/01 – P25/28
Club Casino:
P19/01 – P19/18; P22/01 – P22/05
Poster set up time is 08:00 – 09:00. Each poster will be displayed for one day only. The
presenting author (or one of the co-authors) is asked to stand by their posters at least
during lunch time and coffee breaks to answer questions from viewers.
Authors have to dismantle their posters before 18:00 on the day of the poster session.
16
Information
Registration Desk
Opening hours:
Saturday, August 31st, 2013: Sunday, September
1st,
2013: Monday, September 2nd, 2013: Tuesday, September
3rd,
2013: 16.00 – 18.00
07.00 – 10.15 and 15.00 – 18.30
07.00 – 18.30
07.00 – 18.30
Wednesday, September 4th, 2013: 07.00 – 09.00
Shopping Hours
In summer time, shops vary in their opening hours. Many souvenir shops are open daily
from 08.00 until evening (19.00 or even until 21.30).
Smoking Policy
Smoking is forbidden in the conference venue and the evening venues. Smoking is banned
in Switzerland in public places, on public transport, in stores, restaurants and pubs; some
restaurants and pubs may have so-called “Fumoirs”, where smoking is permitted. Hotels
may offer special smoking rooms. Please indicate your request on the registration form,
when you make your hotel reservation.
17
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More benefits
with fewer side effects.
This molecule may hold
the key to better treatment
of many diseases.
Our innovations
help millions of people by
alleviating their suffering and
improving their quality of life.
We give them hope.
We Innovate Healthcare
18
Information
Social Programme
The focus of the social programme is to provide you with opportunities to network with your colleagues from all over the world. EUROTOX 2013 in Interlaken
will provide numerous opportunities for discussions and interactions between
participants. Key events will be the Welcome Reception on Sunday evening, the
EUROTOX 2013 Party on Monday evening and the Congress Dinner on Tuesday
evening.
Welcome Reception – Sunday
The Welcome Reception at the Interlaken Congress Centre on Sunday (starting at 19.30) is
the first networking opportunity to meet colleagues and friends and make new contacts. It
will take place in the ‘Concert Hall’ (exhibition area allowing interaction with the exhibitors), in the ‘Ball Room’and the ‘Club Casino’.
EUROTOX 2013 Party – Monday
On Monday evening (starting at 19.00) a get-together party will be organized in a relaxed
setting in “DAS ZELT”, a large marquee next to the Congress Centre. Depending on the
weather, please remember: it is a tent!
Simple drinks and light food will be served at no costs. Additional drinks may be purchased
on your own expense.
Our colleague Armin Wolf and his band “Just For Fun” will take care of the entertainment.
Congress Dinner – Tuesday
On Tuesday evening (starting at 19.30) the Congress Dinner will be held in the ‘Congress
Hall’ of the Congress Centre. The renowned kitchen of the ‘Congress Centre Kursaal Interlaken’ will do its utmost to satisfy your palate.
Coffee Breaks and Lunches
Coffee and lunches will be served, normally in the ‘Congress Hall’, in close proximity to and
within the exhibition area.
Pre- and Post-Congress Programme
September is an ideal time to visit Interlaken and the Bernese Oberland area, so you will
have the opportunity to combine work and pleasure before or after your stay, especially
when you bring your family along.
Accompanying persons will be invited to participate in a sight-seeing walk through Interlaken on Monday morning, during which the expert guide will point out places of (historic)
interest.
19
Skill: Advanced technologies in synthesis and analysis
from small to large scale synthesis (micro Ci-Ci)
Quality: In accordance with ISO-9001 system
We offer custom synthesis of C-14 and H-3-labelled
compounds with customer's satisfaction.
Successful business relations with customers in EU, US,
Japan, South America, Australia.
20
Information
Business Meetings
Saturday, August 31st, 2013
08.30 – 10.30
Rugen
EUROTOX Core Executive Committee
11.00 – 18.00
Rugen
EUROTOX Executive Committee
Monday, September 2nd, 2013
12.00 – 13.00
Theatre Room Communication Sub-Committee
12.00 – 13.00
Grimsel 1+2
Education Sub-Committee
12.00 – 13.00
Brünig 1–3
EUROTOX Individual Members
12.00 – 13.00
Harder 1+2
Registration Sub-Committee
12.00 – 13.00
Ball Room
Moleular Toxicology Sub-Committee
12.00 – 13.00
Susten EUROTOX 2014 Scientific Programme Committee
16.30 – 17.30
Grimsel 1+2
Exhibitors Meeting
Tuesday, September 3rd, 2013
12.00 – 13.00
Theatre Room Carcinogenesis Sub-Committee
12.00 – 13.00
Ball Room
ERAS Risk Assessment Sub-Committee
12.00 – 13.00
Grimsel 1+2
ITCASS Immunotoxicology Sub-Committee
12.00 – 13.00
Harder 1+2
EUROTOX Business Council Luncheon
13.00 – 15.30
Harder 1+2
EUROTOX Business Council Meeting
16.00 – 18.00
Grimsel 1+2
YSA / BH Poster Award Evaluation Meeting
Wednesday, September 4th, 2013
08.30 – 09.30
Rugen
EUROTOX Executive Committee Meeting
09.30 – 10.30
Harder 1+2
Corporate Program Sub-Committee
14.15 – 15.15
Harder 1+2
Swiss Society of Toxicology – General Assembly
21
22
Theatre Room
Coffee Break
CEC 1 (–16.40)
14.30 – 15.00
15.00 – 15.30
18.00 – 19.30
16.30 – 17.00
15.30 – 16.30
CEC 1
13.00 – 14.30
CEC 5
Statistical evaluation in toxicology
Susten
BHMF Symposium
Coffee Break
CEC 5
BHMF Symposium CEC 5
Lunch
12.00 – 13.00
Coffee Break
CEC: Registration BHMF Symposium
and Coffee
Congress Hall
CEC 1
BHMF Symposium
Dietary exposure
assessments – current scenario and
emerging issues
Opening
Ceremony
Auditorium
10.30 – 12.00
10.00 – 10.30
09.30 – 10.00
09.00 – 09.30
Room
Sunday, September 1st, 2013
CEC 4
CEC 4
CEC 4
3d cell models in
drug safety: with
better tools to
better drugs?
Harder 1+2
Scientific Programme Overview
CEC 3 (–16.00)
CEC 3
CEC 3
Alternative test
methods: challenges and regulatory application
Brünig 1–3
CEC 2
CEC 2
CEC 2
New methods to
assess contact
sensitizing potential of chemicals
Grimsel 1+2
23
Symposium 6
Challenges with
immunogenicity
of biologics
Symposium 7
RISK21: Novel
thinking for 21st
century risk
assessment
16.30 – 18.30
Symposium 5
Renal toxicology –
epidemiology,
mechanisms and
risk assessment
Coffee Break
Symposium 4
Stem cell derived
tissues in safety
assessment
ILSI / HESI Lecture Lunch and
Poster Viewing
Keynote Lecture 2
16.00 – 16.30
14.00 – 16.00
13.00 – 14.00
12.00 – 13.00
11.00 – 12.00
Symposium 2
Recent developments in risk
assessment of
nanomaterials
and nano safety
science
10.00 – 11.00
Workshop 2
Pesticide exposure and risk assessment by field
measurements
and model approaches
Coffee Break
Keynote Lecture 1
08.30 – 09.30
Congress Hall
09.30 – 10.00
Auditorium
Room
Monday, September 2nd, 2013
Symposium 8
New challenges
for risk assessment: how innovation can make the
difference
Workshop 5
Closing the gap
between academic
research and regulatory risk assessment of chemicals
Symposium 3
Profiling the toxicity of new drugs: a
non animal-based
approach integrating toxicodynamics and biokinetics
Theatre Room
Workshop 6
Preclinical safety
assessment: evolution of sciencebased decision
making
Workshop 4
Advances in the
application of
the Threshold
of Toxicological
Concern (TTC) as a
pragmatic risk assessment tool for
cosmetics
Symposium 1
Early Safety assessment: considerations and
strategies in drug
discovery
Ball Room
Workshop 7
Connexin-based
cellular signaling
and its relevance
to toxicology
Oral Session 2
Models for assessing organ toxicity
Workshop 3
Carcinogenicity
testing for pharmaceuticals
Roundtable
Discussion
Risk versus hazard
in Europe
Informative
Session
WHO
Workshop 1
Immunotoxicants:
modes of action
and pathways to
toxicity
Brünig 1–3
Exhibitor-hosted
Session
AnaPath
Oral Session 1
Computational
toxicology & Endocrine disruption
Harder 1+2
Sponsor-hosted
Session
EBT
Exhibitor
Hosted Session
MPI
Grimsel 1+2
Overview
Concert Hall
and
Club Casino:
Business
Exhibition
Concert Hall,
Club Casino
and
Auditiorium
Foyer:
Scientific
Posters
24
16.00 – 18.00
Symposium 13
Toxic injury to the
lung: mechanisms
and consequences
Symposium 11
The Extended One
Generation Reproductive Toxicity
(EOGRT) assay- scientific challenges
and regulatory
implementation
13.30 – 15.30
15.30 – 16.00
12.15 – 13.15
EUROTOX –
SOT Debate
12.00 – 13.30
11.00 – 12.00
Coffee Break
Lunch and
Poster Viewing
Symposium 14
Cardiovascular
toxicity in drug
dicovery and development
Symposium 12
Integration of
human and environmental risk
assessment – is it
the future?
Workshop 10
Symposium 10
Genetic Suscepti- Mechanism-based
bility: relevance to safety biomarkers
toxicology
Symposium 9
Assessment and
control of genotoxic drug impurities
10.00 – 11.00
Theatre Room
Coffee Break
BHMF Lecture
08.30 – 09.30
Congress Hall
09.30 – 10.00
Auditorium
Room
Tuesday, September 3rd, 2013
Workshop 13
miRNAs: mechanisms and safety
issues
Workshop 11
New approaches
to unravel toxicities based on
compound activity
observed in zebrafish
Workshop 9
The toxicology
of drug delivery
systems
Ball Room
Oral Session 5
Genotoxicity,
Carcinogenicity
& Mechanisms in
Toxicology
Oral Session 4
Environmental
toxicology, Food
toxicology & Novel
analytical techniques
Oral Session 3
Nanotoxicology,
Immunotoxicology & Dermatoxicology
Harder 1+2
Workshop 14
Addressing safety
in the immature
organism: about
children’s safety
and risk-assessment
Workshop 12
Identifying, assessing and managing allergens in
food
Exhibitor
Hosted Session
Huntingdon
(–13:00)
Workshop 8
Risk perception
and communication
Brünig 1–3
Exhibitor
Hosted Session
ACEA (in consistency with other
exhibitor hosted
sessions)
Grimsel 1+2
Concert Hall
and
Club Casino:
Business
Exhibition
Concert Hall,
Club Casino
and
Auditiorium
Foyer:
Scientific
Posters
25
Symposium 15
Tiered approaches
to assess complex
mixtures
08.30 – 10.30
Symposium 17
Reactive metabolites and drug toxicity: contribution,
mechanisms and
novel approaches
Closing Ceremony
11.00 – 13.00
13.10 – 14.10
10.30 – 11.00
Auditorium
Room
Congress Hall
Symposium 18
Nuclear receptors
integrate metabolic and environmental signals to
regulate cell fate
Symposium 16
New developments in “omics”
for use in risk assessment
Theatre Room
Wednesday, September 4th, 2013
Ball Room
Workshop 17
Assessment of azo
dyes and aromatic
amines in food
additives, cosmetics and consumer
products
Harder 1+2
Workshop 18
Ecological risk
assessment in the
21st century: taking into account
mechanistic data
Oral Session 6
Neurotoxicology,
Developmental
Toxicology &
miRNAs
Business
Exhibition
Workshop 16
Predicting chronic
toxicity to establish level of
safety concern in
absence of toxicological data
Workshop 15
Translational
imaging in nonclinical safety applications
Overview
Coffee Break
Concert Hall,
Club Casino
Grimsel 1+2
Brünig 1–3
Sunday, September 1st, 2013
09.00 – 17.00
Satellite Symposium on “New Advances in Risk Assessment”
Chair: Herman Autrup, Denmark
Room: Theatre Room
Sponsored and organised by the Bo Helmstedt Memorial Foundation – BHMF
The symposium will integrate the latest scientific knowledge and methodology into the development of a new paradigm of human health risk assessment from hazard to exposure
driven. This work is currently ongoing in both the US (EPA) and EU (DG Sanco).
The symposium will be based upon two sessions, one focusing on exposure assessment and
the second one focusing on hazard assessment supplemented by a lecture on integration of
non-chemical stressors into chemical risk assessment. A panel discussion with representatives
from EPA, DG Sanco, academia and industrial stakeholders will conclude the symposium.
09.00 – 09.10
Welcome: Herman Autrup, Denmark
09.10 – 09.40
System biology – exposure assessment: John Wambough, USA
09.40 – 10.10
Exposomes: Paolo Vineis, UK
10.30 – 11.00
GIS-based monitoring and chip technologies: Dennis Sargiannis, Greece
11.00 – 11.30
Toxicokinetics – internal dose and in vitro vs in vivo: Emanuela Testai, Italy
11.30 – 12.00
Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review: Thea de Wet, South Africa
13.00 – 13.30
Mode of action: Alan Boobis, UK
13.30 – 14.00
Incorporating new technologies into toxicity testing and chemical risk assessment: moving
from 21st Century vision to a data-driven framework: Rusty Thomas, USA
14.00 – 14.30
Computational toxicology – read across: Chihae Yang, USA
14.30 – 15.00
Probabilistic risk assessment: Wout Slob, The Netherlands
15.20 – 17.00
Panel discussion: DGSANCO, ECHA, US EPA, (ICCA), RISK21 (academia)
26
10.00 – 16.40
Chair: David Tennant, UK
Room: Congress Hall
Organised and supported by the International Life Sciences Institute (ILSI Europe)
Dietary exposure assessment is a key component of any risk-benefit assessment, yet it
is clear that there is a lack of reliable methodology in this area for assessing consumer
exposures to both food constituents and non-food products. Dietary exposure assessment
is needed for substance groups of varying chemistries, functions and concentration levels
in foods. Assessment guidance is available for individual types of substances, but guidance
and practicalities of assessment vary among substance types.
This course aims to raise awareness on key aspects of dietary exposure assessment across
different substance types, including emerging issues in methodology, availability of food
consumption data, and EU-wide efforts to compile harmonised food consumption data.
Modelling of dietary exposure will be demonstrated using case studies on deterministic
and probabilistic assessment as well as acute and chronic dietary exposure, for different
types of chemicals. Uncertainties in this modelling will be discussed and methods to quantify uncertainty will be lined out.
Participants will finally be introduced to the GUIDEA website as a tool to find up-to-date
guidance on dietary exposure assessments. GUIDEA uses a Wikimedia platform which will
be an important reference source for stakeholders, providing concise guidance on the
planning, conduct, reporting and interpretation of exposure assessments.
1 Session background and overview: Diána Bánáti, ILSI Europe, Belgium
2 Emerging/developing issues in conducting dietary exposure/intake assessment:
Jürgen Koenig, Austria
3 Dietary exposure modelling of chemicals: Polly Boon, The Netherlands
4 Refinement of dietary assessment methods: Davide Arcella, Italy
5 Quantification of uncertainties: Marc Kennedy, UK
6 Assessing uncertainties in dietary exposure analysis – improving confidence in results:
Susanne Kettler, Belgium
7GUIDEA – guidance for dietary intake exposure assessment – e-learning tool:
David Tennant, UK
27
Sunday
September 1st
CEC 1: Dietary exposure assessments – current scenario
and emerging issues
09.30 – 16.30
CEC 2: New methods to assess contact sensitizing
potential of chemicals
Chairs: Emanuela Corsini, Italy and Raymond Pieters, The Netherlands
Room: Grimsel 1+2
Organized by the EUROTOX Immunotoxicology and
Chemical Allergens Specialty Section
Allergic contact dermatitis (ACD) is to a considerable extent a preventable disease. A correct detection of skin sensitizers, the characterization of potency, the understanding of
human skin exposure, and the application of adequate risk assessment and management
strategies can all contribute to a reduction of ACD.
From March 2013 onward the ban on animal use to assess repeated dose toxicity, including
sensitizing potential, of cosmetic ingredients is definitive. Due to the new European policy
on chemicals (REACH), in vitro methods are also likely to play a major role in the near
future. Growing political and practical resistance to toxicity testing in animals has driven
the development of animal-free methods for screening and prioritization of toxicants,
including those causing allergic hypersensitivity. Over the last decade, incredible progress
has been achieved and several in vitro methods have been proposed both from academia
and industries to identify the potential of chemicals to induce skin sensitization.
The SENS-IT-IV project is one of the important projects sponsored by the EU to promote
the development of alternative testing to animals. The SENS-IT-IV project has provided
many mechanism-based assays, which together may provide a strategy to address the
issue of contact sensitization. This CEC aims to provide the up-to-date status to inform
all stakeholders interested in this subject.
Course introduction: Raymond Pieters, The Netherlands
1 Pathogenesis of contact sensitization induction: Erwin Roggen, Denmark
2 QSAR and peptide binding assay: Jean Pierre Lepoittevin, France
3 Skin absorption and keratinocyte models: Emanuela Corsini, Italy
4 Skin models and DC migration: Sue Gibbs, The Netherlands
5 T cell priming assays for contact sensitization: Stefan Martin, Germany
6 Tiered approach to test contact sensitizers: Marc Teunis, Netherlands
7 Colipa (Cosmetics Europe) strategy to assess contact sensitizing potential of chemicals:
Kerstin Reisinger, Germany
28
10.00 – 16.00
Chair: David Bell, Finland
Room: Brünig 1–3
Organised and supported by the European Chemicals Agency
Alternative test methods to traditional animal testing, and non-test methods, offer the
prospect of numerous potential benefits, including reduced costs, increased coverage of
chemical space, higher throughput and ethical benefits. These test methods are also of
growing interest to regulators, for example with the cosmetics directive. However, it is
important to be able to understand the scientific basis for these tests, and the application
of that science within specific regulatory frameworks. This course aims to elucidate key
scientific and regulatory principles underlying the application of these test methods. The
session will open with examining the challenges for regulatory acceptance and recognition
of test methods, and explaining how recently developed policies are aimed at dealing with
these challenges. The following three presentations set out scientific areas which have
regulatory applications. The fifth presentation will provide a status report of areas where
testing is and is not feasible, and explain future prospects for their development. Finally,
the last speaker will explain with the example of ‘read-across’ how an alternative method
is applied in a regulatory setting. Students will have the opportunity to interact with
speakers through a question and answer session.
At the end of the session, participants will have developed an understanding of the
status quo for alternative methods, the scientific concepts and constraints that underpin
alternative test methods, the concepts associated with acceptance and recognition of
test methods, and the application of these test methods within a regulatory context.
Course introduction: David Bell, Finland
1 EURL ECVAM recommendations – a new tool towards regulatory acceptance of
alternative test methods: Claudius Griesinger, Italy
2 The application of QSARs in regulatory toxicology: Mark Cronin, UK
3 In vitro- in vivo extrapolation for toxicity and use in PBPK: Amin Rostami, UK
4 In vitro tests for irritation and corrosion – a continuing success story: Laura Rossi, Finland
5 The EC report on “Alternative (non-animal) methods for cosmetics testing: current
status and future prospects – 2010”: Valerie Zuang, Italy
6 Regulatory application of non-test methods; the example of read-across in REACH:
Karel de Raat, Netherlands
Panel discussion; Questions & Answers
29
Sunday
September 1st
CEC 3: Alternative test methods: challenges and regulatory
application
09.30 – 16.30
CEC 4: 3d cell models in drug safety: with better tools to
better drugs?
Chairs: David Kaplan, USA and Linda Griffith, USA
Room: Harder 1+2
Sponsored by the Bo Holmstedt Memorial Foundation (BHMF)
Selection of drug candidates early on in development has become increasingly important
to minimize use of animals and to avoid costly failures of drugs later on. In vitro systems to
predict and assess organ toxicity have been of limited value so far due to difficulties in recapitulating in vivo-relevant toxicity on a cell culture level. To overcome the limitations of
single cell type monolayer cultures and short-lived primary cell preparations, researchers
have created novel 3-dimensional culture systems which appear to more closely resemble
in vivo biology. These may become key for drug industry in the evaluation of drug candidates, yet, the value and acceptance of those new models in standard drug safety applications needs to be demonstrated. The sessions aims to give an overview of different approaches undertaken in the field of pre-clinical safety assessment and in particular organ
toxicity.
Opening remarks & introduction to the course: Session Chairs
1 Development of advanced tissue models for in vitro toxicity testing: ZhanFeng Cui, UK
2 Kidney injury and disease modelling in silk based 3d in vitro systems: David Kaplan, USA
3 3d cardiac models: Jens Kelm, Switzerland
4 Long-term 3d culture systems to detect human-specific liver toxicants
Adrian Roth: Switzerland
5 Human organo-typical (HOT) co-cultures for functional substance screening
Manfred Schmolz: Germany
6 Human 3d tissue cultures to assess metabolism of drugs: Tommy Andersson, Sweden
7Integration of systems biology and tissue engineering for drug development:
Linda Griffith, USA
30
9.30 – 16.30
CEC 5: Statistical evaluation in toxicology
This practical course is designed for toxicologists who have the need to generate or interpret data in toxicology. Special emphasis is placed on hands-on application using R-software and real data without use of complex mathematical formulae. In the first session the
principles for multiple comparisons are explained for the analysis of normally distributed
as well as skewed endpoints. In part ii) the related evaluation of mutagenicity assays is explained: count or proportions as endpoints, using a k-fold relevance criteria, and taking
possible downturn effect at high doses into account. In part iii), the basic concepts of
dose-response modelling are introduced: commonly used models (e.g., log-logistic /Hillslope model) and their toxicological interpretation. The principles of ECxx and benchmark
dose estimation are explained. The second session starts with exercises using R for the
first session. A number of case studies using the R packages bmd and drc demonstrate
how to carry out dose-response analysis for standard assays. In part ii), we will discuss the
estimation of the AUC in sparse sampling situations, discuss the role of the AUC in toxicokinetic studies and illustrate the use of the R package PK for that purpose. In the third session, the proof-of-safety approach “significant toxicity” (Denton et al. Environ. Tox. Chem,
2011,30,1117-1126) will be discussed. Finally, practical exercise sessions will allow you perform the analysis of real toxicity data using the R packages multcomp, mratios, MCPAN,
nparcomp, PK and drc. The data examples (as xls and txt files), the program code and a
short user guide to R will be provided in advance of the course. We recommend that participants bring their own notebook – with installed R and selected packages – to the
course.
1 Principles and analysis of repeated toxicity studies: Ludwig A. Hothorn, Germany
2 Evaluation of mutagenicity assays: Ludwig A. Hothorn, Germany
3 Dose-response modeling: Christian Ritz, Denmark
4 Exercise I using R
5 Toxicokinetics: Thomas Jaki, UK
6 Exercise II using R
7 Signicant toxicity approach: Ludwig A. Hothorn, Germany
Final discussion
31
Sunday
September 1st
Chairs: Ludwig A. Hothorn, Germany, Christian Ritz, Denmark and Thomas Jaki, UK
Room: Susten
EUROTOX 2013 – Opening Ceremony
Chair: Ruth Roberts, President of EUROTOX, UK
Room: Auditorium
18.00 – 18.45 Opening Ceremony
• Welcome address by Thomas Weiser
President of the EUROTOX 2013 congress, Basel, Switzerland
• Welcome address by Pascal Strupler
Director of the Federal Office of Public Health, Bern, Switzerland
• Welcome address by Urs Graf
Mayor of the city of Interlaken, Switzerland
• Opening of EUROTOX 2013 by Ruth Roberts
President of EUROTOX, Macclesfield, United Kingdom
18.45 – 19.00 EUROTOX Merit Award Ceremony
• Awarded Scientist (tbd)
Chair: Ruth Roberts
President of EUROTOX, Macclesfield, United Kingdom
19.00 – 19.30 Keynote Lecture
• „From room odorizers, bath salts and plant food – New psychoactive substances on
the rise“
Thomas Kraemer
Institute of Legal Medicine, University of Zürich, Switzerland
32
Monday, September 2nd, 2013
08.30 – 09.30
Keynote Lecture 1: Public health impact of food; quantity,
quality, supplements and appetites
Monday
September 2nd
Prof. Sir Colin Berry, Prof. Emeritus of Pathology, Queen Mary University of London, UK
Chair: Werner Kobel, Switzerland
Room: Auditorium
10.00 – 12.00
Symposium 1: Early safety assessment: considerations
and strategies in drug discovery
Chair: Thomas Hartung, USA
Room: Ball Room
10.00 – 10.20
Fail early and learn fast – how early safety testing impacts drug attrition: Susanne Mohr,
Switzerland
10.25 – 10.45
Early off-target assessments for the prediction of safety liabilities – case studies: Andreas
Hartmann, Switzerland
10.50 – 11.10
Structure-based assessment of potentially mutagenic impurities – processes aligned to
ICH M7 step 2 document at Bayer HealthCare: Andreas Sutter, Germany
11.15 – 11.35
Leveraging early pharmacology studies and animal models of human disease to learn
about toxicity: Eckart Krupp, Germany
11.40 – 12.00
Early safety assessment of biologicals: Jennifer Sims, Switzerland
33
10.00 – 12.00
Symposium 2: Recent developments in risk assessment
of nanomaterials and nano safety science
Chairs: Yasuo Yoshioka, Japan and Akihiko Hirose, Japan
Room: Congress Hall
This Symposium is sponsored by the Bo Holmstedt Memorial Foundation (BHMF).
10.00 – 10.20
Nanomaterials as a potential cause of lung disease: James C. Bonner, USA
10.25 – 10.45
Safety consideration of nanomaterials for biomedical applications: Chunying Chen, China
10.50 – 11.10
Nanoparticles as an emerging environmental and occupational hazard: Anna A. Shvedova,
USA
11.15 – 11.35
Dosimetry of nanomaterials after different routes of exposure: Wolfgang Kreyling,
Germany
11.40 – 12.00
Nanotoxicity and nano safety science in various exposure scenarios: Akihiko Hirose, Japan
10.00 – 12.00
Symposium 3: Profiling the toxicity of new drugs:
a non animal-based approach integrating toxicodynamics
and biokinetics
Chairs: Armin Wolf, Switzerland and Stefan Müller, Germany
Room: Theatre Room
This Symposium is sponsored by ACEA Bio.
10.00 – 10.20
Predict-IV project overview (EU grant 202222): non animal-based toxicity profiling by integrating toxico-dynamics and biokinetics: Armin Wolf, Switzerland
10.25 – 10.45
An integrated ‘omics’ approach to characterise nephrotoxin induced stress responses in
renal epithelial cells: Paul Jennings, Austria
10.50 – 11.10
The relevance of toxicokinetics in in vitro studies: Emanuela Testai, Italy
34
11.15 – 11.35
Integrating Toxicokinetics and Toxicodynamics to predict toxic responses in vivo:
Frédéric Bois, France
11.40 – 12.00
The virtual liver: possibilities to simulate mechanisms of toxicity and predict drug targets:
Jan Hengstler, Germany
10.00 – 12.00
Monday
September 2nd
Workshop 1: Immunotoxicants: modes of action and
pathways to toxicity
Chair: Raymond Pieters, The Netherlands
Room: Brünig 1–3
10.00 – 10.25
Application of ‘omics’ to immunotoxicology: from mechanisms of action to alternative
methods: Oscar Volger, The Netherlands
10.30 – 10.55
Aryl hydrocarbon receptor activation: new insides on TCDD immunotoxicity:
Raymond Pieters, The Netherlands
11.00 – 11.25
Signal transduction pathways activated by contact allergens: in vitro opportunities for
the identification of chemical allergens: Andreas Natsch, Switzerland
11.30 – 11.55
Glucocorticoid receptor and signal transduction pathway associated with immune cell
activation: Marco Racchi, Italy
10.00 – 12.00
Workshop 2: Pesticide exposure and risk assessment by field
measurements and model approaches
Chairs: Claudio Colosio, Italy and Aristidis Tsatsakis, Greece
Room: Auditorium
10.00 – 10.20
Pesticide exposure of agricultural workers in Greece. Biomarkers diversity and variability:
Aristidis Tsatsakis, Greece
10.25 – 10.45
Typical exposure levels in Europe and in tropical countries: Francisco Javier Egea González,
Spain & Richard Glass, UK
35
10.50 – 11.10
Definition of AOEL-based provisional BEIs for pesticide exposure monitoring: a proposed
approach for the protection of farmer’s health: Claudio Colosio, Italy
11.15 – 11.35
Pesticide and biocide exposures in the UK: John Cocker, UK
11.40 – 12.00
The PESTEXPO program: results of pesticide measurements in vinegrowing and development of exposure algorithms: Isabelle Baldi, France
10.00 – 12.00
Oral Session 1: Computational toxicology & Endocrine
disruption
Chair: Alex Odermatt, Switzerland
Room: Harder 1+2
10.00 – 10.15
Generalized workflow for generating high quality in-silico models for off-target mediated
toxicity: Lennart T. Anger, Germany
10.15 – 10.30
Multi-scale modeling for individualized spatiotemporal prediction of drug effects: Juan G.
Diaz-Ochoa, Germany
10.30 – 10.45
Pharmacophore-based virtual screening as a prioritization tool to assess mechanism-based
cardiotoxic effects of small organic molecules: Daniela Schuster, Austria
10.45 – 11.00
Pharmacophore-based virtual screening in the search for endocrine disrupting chemicals –
successful case studies: Anna Vuorinen, Austria
11.00 – 11.15
Endocrine modulatory effects of cadmium and the molecular mechanism of action:
Ali Imran, Sweden
11.15 – 11.30
Overview of the existing regulations and testing programs for endocrine active chemicals:
Simon Warren, USA
11.30 – 11.45
Determination of Bisphenol A exposure in rural and urban area populations in Mersin City:
Turkey: Dilek Battal, Turkey
11.45 – 12.00
A case study of risk assessment in Malaysia: Letchumi Thannimalay, Malaysia
36
10.00 – 11.00
Exhibitor-hosted Session
Room: Grimsel 1+2
How do I get into Phase 1 Trials with my compound?
Scott Boley, MPI Research, USA
For details see page 62
12.00 – 13.00
Monday
September 2nd
ILSI/HESI Lecture
Emerging needs for chemical safety and risk assessment
in Europe
David R. Bell, European Chemicals Agency, Finland
Chair: Syril D. Pettit, HESI Executive Director, USA
Room: Auditorium
13.00 – 14.00
Keynote Lecture 2: Reliability of toxicology without
experimental animals? Possibilities and limitations
since the ban of animal experiments with cosmetics
Prof. Franz Oesch, University of Mainz, Germany
Chair: Michael Arand, Switzerland
Room: Auditorium
13.00 – 14.00
Sponsor-hosted Session
Room: Grimsel 1+2
Evidence-based Toxicology Collaboration
Chair: Thomas Hartung, USA
For details see page 62
37
13.00 – 13.45
Informative Session
Room: Brünig 1–3
The WHO chemical risk assessment network: A new global collaborative approach to human health risk assessment
Chair: Carolyn Vickers, World Health Organization, Geneva, Switzerland
13.00 – 13.15
Background and rationale for a global chemical risk assessment network: Martin Wilks,
Switzerland
13.15 – 13.30
Objectives, setup and ways of working for the WHO Chemical Risk Assessment Network:
Carolyn Vickers, Switzerland
13.30 – 13.45
Current and planned projects of the WHO Chemical Risk Assessment Network: Alan
Boobis, UK
13.00 – 14.00
Exhibitor-hosted Session
Room: Harder 1+2
Pathology evaluation involved in the development of ATMPs
Klaus Weber and colleagues, AnaPath GmbH, BSL Bioservices Scientific Laboratories GmbH
and collaboration groups
For details see page 63
14.00 – 16.00
Symposium 4: Stem cell derived tissues in safety assessment
Chair: Kyle Kolaja, USA
Room: Auditorium
14.00 – 14.20
Safety issues in human pluripotent stem cells: Nissim Benvenisty, Israel
14.25 – 14.45
The use of stem cells in discovery and toxicology: Heinz Ruffner, Switzerland
14.50 – 15.10
Realizing the potential of IPS cells and derived tissues – from banking to improved safety
assessment to microphysiological systems: Kyle Kolaja, USA
38
15.15 – 15.35
Stem cell derived cardiomyocytes – application review: Stefan Braam, The Netherlands
15.40 – 16.00
Novel iPSC-derived hepatic model systems for investigating mechanisms of idiosyncratic
Drug-Induced Liver Injury (DILI): Ed LeCluyse, USA
Symposium 5: Renal toxicology – epidemiology, mechanisms
and risk assessment
Chairs: Angelika Tritscher, Switzerland and Felix Carvalho, Spain
Room: Congress Hall
14.00 – 14.20
Epidemiology and causation of human renal disease; the case of aristolochic acid
nephropathy: Volker Arlt, UK
14.25 – 14.45
Nephrotoxicity of melamine, cyanuric acid, and their combination: Gonçalo Gamboa, USA
14.50 – 15.10
Mechanisms of renal disease – Ochratoxin A: Angela Mally, Germany
15.15 – 15.35
Renal toxicology in drug attrition: Magnus Söderberg, Sweden
15.40 – 16.00
Integration of epidemiological and toxicological information into risk assessment – the
melamine example: Angelika Tritscher, Switzerland
14.00 – 16.00
Workshop 3: Carcinogenicity testing for pharmaceuticals
Chairs: Paul Baldrick, UK and Peter Heining, Switzerland
Room: Harder 1+2
14.00 – 14.25
Carcinogenicity testing for pharmaceuticals – an update: Paul Baldrick, UK
14.30 – 14.55
Practical considerations when setting up and conducting a carcinogenicity study:
Guy Healing, UK
39
Monday
September 2nd
14.00 – 16.00
15.00 – 15.25
Transgenic versus conventional carcinogenicity testing: David Jones, UK
15.30 – 15.55
Case studies or how to deal with ‘difficult’ results: Martin Bopst, Switzerland
14.00 – 16.00
Workshop 4: Advances in the application of the Threshold of
Toxicological Concern (TTC) as a pragmatic risk assessment
tool for cosmetics
Chair: Alan Boobis, UK and Co-Chair: Heli Hollnagel, Switzerland
Room: Ball Room
This Symposium is sponsored by ILSI EUROPE.
14.00 – 14.20
Chemical risk assessment in absence of adequate toxicological data: Benoît Schilter,
Switzerland
14.25 – 14.45
TTC Task Force: Development of a cosmetics database to support application of TTC to
cosmetic ingredients (EU Cosmos project): Heli Hollnagel, Switzerland
14.50 – 15.10
Threshold of toxicological concern (TTC) task force: a strategy to support application of
TTC to dermally applied cosmetic ingredients: Faith M. Williams, UK
15.15 – 15.35
Risk assessment of genotoxic carcinogens task force. Use of TTC for contaminants with
potential genotoxic hazard: Alan Boobis, UK
15.40 – 16.00
Future directions for TTC: Heli Hollnagel, Switzerland
14.00 – 16.00
Workshop 5: Closing the gap between academic research and
regulatory risk assessment of chemicals
Chairs: Christina Ruden, Sweden and Marlene Agerstrand, Sweden
Room: Theatre Room
14.00 – 14.20
Risk to all or none? The Bisphenol A risk controversy: Anna Beronius, Sweden
40
14.25 – 14.45
Ensuring reliability and relevance of academic research for regulatory assessments –
some practical considerations: Sharon Munn, Italy
14.50 – 15.10
How is new science used in regulatory approaches for dealing with endocrine disrupters?
Andreas Kortenkamp, UK
15.15 – 15.35
Editors’ and Reviewers’ roles in promoting quality publications: James Kehrer, Canada
Monday
September 2nd
15.40 – 16.00
Discussion: What is needed to close the gap between science and regulatory risk
assessment? All speakers
14.00 – 16.00
Oral Session 2: Models for assessing organ toxicity
Chair: Jan G. Hengstler, Germany and Co-Chair: Dieter Schrenk, Germany
Room: Brünig 1–3
14.00 – 14.15
Determination of liver specific toxicities in rat hepatocytes by High Content Imaging
during 2-week multiple treatment: Davide Germano, Switzerland
14.15 – 14.30
3d hepatocyte cultures: a useful tool in the study of Nevirapine bioactivation and toxicity:
Joana P. Miranda, Portugal
14.30 – 14.45
A physiologically relevant HepG2 cell based 3D cell culture model for high throughput
toxicity studies: Sreenivasa Ramaiahgari, The Netherlands
14.45 – 15.00
A 4D lung multi-culture system mimicking alveolar cellular organization to study the
toxic potential of airborne particles: Tommaso Serchi, Luxemburg
15.00 – 15.15
Predictive human kidney-specific in vitro models: Yao Li, Singapore
15.15 – 15.30
An in vitro model of the renal proximal tubule composed of small intestinal submucosa
(SIS) and human kidney-derived cells (hKDCs): Anke Hoppensack, Germany
15.30 – 15.45
Microgravity spheroids as a reliable, long-term tool for predictive toxicology:
Stephen Fey, Denmark
15.45 – 16.00
A novel zebrafish model to predict organ toxicities in mammals: Philip Ingham, Singapore
41
16.30 – 18.30
Symposium 6: Challenges with immunogenicity of biologics
Chair: Valerie Quarmby, USA
Room: Congress Hall
16.30 – 16.50
Challenges with immunogenicity of biologics: Cecilia Tami, USA
16.55 – 17.15
Update on new regulatory guidelines on immunogenicity: Gaby Reichmann, Germany
17.20 – 17.40
IMI project ABIRISK: Anti-biopharmaceutical immunization: prediction and analysis of
clinical relevance to minimize the risk: Marc Pallardy, France
17.45 – 18.05
Drug hypersensitivity and stimulation of the immune system: beyond the hapten concept:
Werner Pichler, Switzerland
18.10 – 18.30
Assessing immunogenicity of therapeutic antibodies in transgenic mice: Antonio Iglesias,
Switzerland
16.30 – 18.30
Symposium 7: RISK21: Novel thinking for 21st century risk
assessment
Chair: Alan Boobis, UK
Room: Auditorium
This Symposium is sponsored by ILSI / HESI USA.
16.30 – 16.50
The HESI RISK21 project: Alan Boobis, UK
16.55 – 17.15
Optimizing the use of exposure information: Herman Autrup, Denmark
17.20 – 17.40
Incorporation of mode-of-action information into dose-response assessment: the
Quantitative Key Events / Dose-Response Framework (Q-KEDRF): Richard Currie, UK
17.45 – 18.05
In vitro to in vivo extrapolation (IVIVE) for human health risk assessment:
Rory B. Conolly, USA
18.10 – 18.30
Assessing cumulative risk to multiple stressors: Angelo Moretto, Italy
42
16.30 – 18.30
Symposium 8: New challenges for risk assessment:
how innovation can make the difference
Chair: Tuomo Karjalainen, Belgium
Room: Theatre Room
This Symposium is sponsored by European Commission, Research and Innovation
Directorate-General, Environment Directorate.
16.40 – 17.00
Challenges in risk assessment of chemicals: DG Environment point of view: Peter Korytar,
Belgium
17.00 – 17.25
Advances in toxigenomics: use for risk assessment: Jos Kleinjans, The Netherlands
17.25 – 17.45
Developmental origins of diseases: Challenge for risk assessment of chemicals: Philippe
Grandjean, Denmark
17.45 – 18.10
Biomarkers of exposure and effect, where are we going? Greet Schoeters, Belgium
18.10 – 18.30
Questions and comments from the audience
16.30 – 18.30
Workshop 6: Preclinical safety assessment: evolution
of science-based decision making
Chair: Ruth Roberts, UK
Room: Ball Room
This Symposium is sponsored by NC3R (UK).
16.30 – 16.50
Strategies in preclinical safety: target organ toxicities, recovery assessment and
significance for clinical development: Ruth Roberts, UK
16.55 – 17.15
Assessment of dependence potential and suicidality liabilities: how non–clinical data help:
Andreas Hartmann, Switzerland
43
Monday
September 2nd
16.30 – 16.40
Introductory remarks: Tuomo Karjalainen, Belgium
17.20 – 17.40
Science-based approaches to carcinogenicity risk assessment for large molecules:
Ron Steigerwalt, USA
17.45 – 18.05
Significance of species and study design in pre-clinical testing of biologics: challenges and
opportunities: Kathryn Chapman, UK
18.10 – 18.30
A prospective view towards investigative safety assessment: Richard Weaver, France
A Culture of Collaboration
At Novartis Institutes for BioMedical Research (NIBR), the global research
organization of Novartis, our ambition is to transform drug discovery and develop
breakthrough medicines that change patient treatment. Our culture of science is
open and entrepreneurial; we are focused on clearly sharing our views and opinions
while listening to the views of others. By hiring the best academic, biotech, and
pharmaceutical-trained scientists, we have fostered an atmosphere for drug discovery
where creativity thrives. Our research is driven by rigorous science and unmet medical
need, not the market size. We have created a dynamic and flexible culture that values
each associate’s diverse background, unique style and wealth of experience.
44
16.30 – 18.30
Workshop 7: Connexin-based cellular signaling and its
relevance to toxicology
Chair: Mathieu Vinken, Belgium
Room: Brünig 1–3
16.30 – 16.55
The role of connexins and their channels in toxicity: Mathieu Vinken, Belgium
Monday
September 2nd
17.00 – 17.25
Mechanisms underlying connexin-mediated bystander cell death: Elke Decrock, Belgium
17.30 – 17.55
The role of connexins and their channels in carcinogenesis: Marc Mesnil, France
18.00 – 18.25
Connexins and benzene toxicity: Edgar Rivedal, Norway
16.30 – 18.30
Roundtable Discussion: Risk versus hazard in Europe
Chairs: Christine Lorez and Martin Wilks, Switzerland
Room: Harder 1+2
This Symposium is sponsored by ECPA.
16.30 – 16.50
Hazard-based regulation in Europe: status of impact in risk assessments: Albert Bergmann,
Austria
16.50 – 17.10
Hazard classification or risk assessment: Ulla Hass, Denmark
17.10 – 17.30
Using hazard characterization in chemical classification. Potency as a key discriminator:
Dick Lewis, Belgium
17.30 – 17.50
Risk and hazard: perspective of a regulatory agency: Roland Solecki, Germany
17.50 – 18.30
Discussion, all speakers
45
Tuesday, September 3rd, 2013
08.30 – 09.30
Bo Holmstedt Memorial Foundation (BHMF) lecture:
The developing brain: Neurotoxic insults and their long
term impact
Sandra Ceccatelli, Sweden
Chair: Herman Autrup, Denmark
Room: Auditorium
10.00 – 12.00
Symposium 9: Assessment and control of genotoxic drug
impurities
Chairs: Lutz Müller, Switzerland and Dieter Schrenk, Germany
Room: Auditorium
10.00 – 10.20
Development of genotoxic impurities guidelines and their impact on regulatory review:
Elisabeth Klenke, Switzerland
10.25 – 10.45
The staged TTC concept in the evaluation of genotoxic impurities in drugs: Lutz Müller,
Switzerland
10.50 – 11.10
Genotoxic impurities in drugs – ‘paper chemistry’ or analytical data? Alexander Amberg,
Germany
11.15 – 11.35
Genotoxic impurities – a quality perspective on analysis and control: Rolf Schulte Oestrich,
Switzerland
11.40 – 12.00
How to apply impurity control procedures to complex mixtures such as herbal medicines:
Olavi Pelkonen, Finland
46
10.00 – 12.00
Symposium 10: Genetic susceptibility: relevance to toxicology
Chairs: Hans Ketelslegers, Belgium and Ruth Roberts, UK
Room: Congress Hall
10.00 – 10.25
Genetic susceptibility: relevance to toxicology: Hans Ketelslegers, Belgium
10.30 – 10.55
Epigenome changes induced by environmental factors and cancer: Zdenko Herceg, France
11.00 – 11.25
In vitro screening for population variability in chemical toxicity: Ivan Rusyn, USA
Tuesday
September 3rd
11.30 – 11.55
Genetic susceptibly: relevance to adverse drug reactions: Ruth Roberts, UK
10.00 – 12.00
Workshop 8: Risk perception and communication
Chairs: Hanspeter Naegeli, Switzerland and Mojmir Mach, Slovakia
Room: Brünig 1–3
10.00 – 10.20
Proper communication of compound-inherent risks: the scientists dilemma: Michael Arand,
Switzerland
10.25 – 10.45
Human functioning in the context of risk: Heinz Gutscher, Switzerland
10.50 – 11.10
Quality criteria in professional risk communication – the editors view: Jan Georg Hengstler,
Germany
11.15 – 11.35
Risk assessment – the needs of an expert panel: Andrea Hartwig, Germany
11.40 – 12.00
Round table discussion
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10.00 – 12.00
Workshop 9: The toxicology of drug delivery systems
Chairs: Heather Wallace, UK and Nursen Basaran, Turkey
Room: Ball Room
10.00 – 10.20
Modifying the risk-benefit ratio using drug delivery systems: Peter Newham, UK
10.25 – 10.45
Drug delivery using endogenous transport systems: Heather Wallace, UK
10.50 – 11.10
Understanding the behavior of nanoparticulate drug delivery systems in vivo: particle
disposition patterns, toxicologic implications and effective drug development:
Richard Kirsh, UK
11.15 – 11.35
Pharmacokinetics and toxicology of nanoparticles in drug delivery: Raymond Yang, USA
11.40 – 12.00
Safety of therapeutic monoclonal antibody conjugates: Nicholas Buss, UK
10.00 – 12.00
Workshop 10: Mechanism-based safety biomarkers
Chair: Dominique Brees, Switzerland
Room: Theatre Room
10.00 – 10.20
Emerging trends in hemostasis biomarkers: David Ledieu, Switzerland
10.25 – 10.45
Current status and future perspectives of renal safety biomarkers: Mark Pinches, UK
10.50 – 11.10
Preclinical (epi)genomics – identifying safety biomarkers for the prediction of
non-genotoxic carcinogenesis: Remi Terranova, Switzerland
11.15 – 11.35
Clinical utility of novel mechanistic biomarkers of drug-induced liver injury:
Daniel Antoine, UK
11.40 – 12.00
Roundtable discussion: Using non-validated safety biomarkers in clinical studies
Moderated by session chairs
48
10.00 – 11.45
Oral Session 3: Nanotoxicology, Immunotoxicology &
Dermatoxicology
Chair: Ioannis Trantakis, Switzerland
Room: Harder 1+2
10.00 –10.15
Transfer of engineered nanoparticles across the human placenta: Stefanie Grafmüller,
Switzerland
10.30 – 10.45
HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin: Werner J. Pichler,
Switzerland
10.45 – 11.00
Use of cytotoxicity-based assays in the in vitro diagnosis of patients with Sevens-Johnson
syndrome: Tatjana Pecaric Pekovic, Switzerland
11.00 – 11.15
A modified oral UV-LLNA in Balb/c mice to investigate phototoxicity mechanisms and
pharmacokinetic properties in skin: Stéphanie Boudon, Switzerland
11.15 – 11.30
Relevance of in-vitro methods for the evaluation of eye and skin irritation/corrosion
potential of aliphatic tertiary amines: Qiang Li, Germany
11.30 – 11.45
Animal-free studies in cosmetic ingredient industry: Perspective and strategy after a
10-year experience: Herve Ficheux, UK
10.00 – 11.00
Exhibitor-hosted Session
Room: Grimsel 1+2
Using the xCELLigence RTCA Cardio System for Assessment of Preclinical Cardiac Safety
Assessment
Yama Abassi, ACEA Biosciences, Inc., USA
For details see page 64
49
Tuesday
September 3rd
10.15 – 10.30
Use of ‘same donor’ endothelial cells and PBMC in co-culture to detect cytokine storm
reactions to a TGN1412-like anti-CD28 antibody: A novel assay for biologic drug safety
screening: Daniel Reed, UK
12.00 – 13.00
Exhibitor-hosted Session
Room: Brünig 1–3
3Rs: refinement techniques for Primates and their effect on data quality
Helen Palmer, Huntington Life Sciences, UK
For details see page 65
12.15 – 13.15
EUROTOX – SOT Debate: In the near foreseeable future,
much of toxicity testing can be replaced by computational
approaches
EUROTOX Debater: George Loizou, UK
SOT Debater: Rory B. Conolly, USA
Chair: Aristidis Tsatsakis, Greece, President Elect EUROTOX and Co-chair: Norbert E.
Kaminski, USA, President Elect SOT
Room: Auditorium
13.30 – 15.30
Symposium 11: The Extended One Generation Reproductive
Toxicity (EOGRT) assay – scientific challenges and regulatory
implementation
Chairs: Helen Håkansson, Sweden and Richard Vogel, Germany
Room: Auditorium
13.30 – 13.50
Practical experience of the EOGRTS protocol in use: Steffen Schneider, Germany
13.55 – 14.15
Analysis of immune toxicity in the extended one-generation reproduction toxicity study:
Aldert Piersma, The Netherlands
14.20 – 14.40
Analysis of developmental neurotoxicity: Sandra Allen, UK
14.45 – 15.05
Developmental toxicity in reproductive organs: Geertje Lewin, Germany
15.10 – 15.30
Epigenetics: how genes and environment interact: Randy Jirtle, USA
50
13.30 – 15.30
Symposium 12: Integration of human and environmental risk
assessment – is it the future?
Chairs: Inge Werner, Switzerland and Lothar Aicher, Switzerland
Room: Theatre Room
This Symposium is sponsered by the Swiss Centre for Applied Human Toxicology and the
Swiss Centre for Applied Ecotoxicology.
13.30 – 13.50
HEROIC – an integrated European approach to the coordination of human and environmental risk assessment: Martin Wilks, Switzerland
14.20 – 14.40
Human risk assessment of drinking water residues from pharmaceuticals: environmental
pathways, pharmacological potency and toxicity: Reinhard Länge, Germany
14.45 – 15.05
Decision-making in human and environmental risk assessment using a weight of evidence
approach: Philippe Ciffroy, France
15.10 – 15.30
Application of probabilistic modelling techniques in human and environmental risk
assessment: Ad Ragas, The Netherlands
13.30 – 15.30
Workshop 11: New approaches to unravel toxicities based on
compound activity observed in zebrafish
Chair: Carles Callol, Spain
Room: Ball Room
13.30 – 13.50
Locomotor activity in zebrafish embryo and larva: alternative assays to evaluate the
developmental neurotoxic potential of chemicals and drugs: Hilda Witters, Belgium
13.55 – 14.15
Resolving the neuropharmacology of zebrafish sleep: Jason Rihel, UK
14.20 – 14.40
The utility of the zebrafish for drug safety assessment: an industry perspective:
Matthew Winter, UK
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Tuesday
September 3rd
13.55 – 14.15
Environmental and drinking water risk assessment of substances which are toxic to
humans or aquatic organisms – examples and options: Robert Kase, Switzerland
14.45 – 15.05
Predicting drug-induced hepatotoxicity in zebrafish larvae: Natalie Mesens, Belgium
15.10 – 15.30
New approach to a predictive toxicity evaluation with a zebrafish assay: Ainhoa Alzualde,
Spain
13.30 – 15.30
Workshop 12: Identifying, assessing and managing allergens
in food
Chair: Yong Joo Chung, Switzerland
Room: Brünig 1–3
13.30 – 13.50
Trends in food allergy and impact on public health: Jonathan Hourihane, Ireland
13.55 – 14.15
A regulator’s approach to risk assessment of food allergens: Sue Hattersley, UK
14.20 – 14.40
Identification of new food allergens of public health relevance: Geert Houben,
The Netherlands
14.45 – 15.05
Experimental approaches to predict allergenic potential of novel food: Charlotte Madsen,
Denmark
15.10 – 15.30
Impact of processing on the allergenic potential of food: Clare Mills, UK
13.30 – 15.15
Oral Session 4: Environmental toxicology, Food toxicology &
Novel analytical techniques
Chair: Rex FitzGerald, Switzerland
Room: Harder 1+2
13.30 – 13.45
Toxicogenomics to group environmental chemicals in vitro? Alessa Ignarski, Switzerland
13.45 – 14.00
Toxicity of microcystin-deficient Planktothrix strains due to chlorine and sulfate containing
aeruginosins: Esther Kohler, Switzerland
52
14.00 – 14.15
Toxicological risk assessment in carbon capture and storage technology: Marcus
Hillebrand, Germany
14.15 – 14.30
Evidence for lipid signaling molecules in glycated protein preparations being responsible
for the stimulation of inflammatory signaling in RAGE expressing cells – potential role of
lysophosphatidic acid: Timo Buetler, Switzerland
14.30 – 14.45
Liquid chromatographic determination of histamine in traditionally salted, smoked and
frozen fish with relation to microbial load: Mohamed Mahmoud Deabes, Egypt
14.45 – 15.00
A refined surgical technique for telemetry in group housed macaques (M. fascicularis):
Jörg Luft, Germany
Tuesday
September 3rd
15.00 – 15.15
Less is more: Better toxicity data from fewer rodents using plasma microsampling:
Anne Eichinger-Chapelon, Switzerland
16.00 – 18.00
Symposium 13: Toxic injury to the lung: mechanisms and
consequences
Chairs: Martin Wilks, Switzerland and Daniela Pelclová, Czech Republic
Room: Auditorium
16.00 – 16.20
Toxic lung injury associated with fever: mechanisms and outcome: Daniela Pelclová,
Czech Republic
16.25 – 16.45
Emerging occupational lung disorders caused by inhaled chemical agents: Benoit Nemery,
Belgium
16.50 – 17.10
Pulmonary consequences of drug use: Bruno Mégarbane, France
17.15 – 17.35
Pulmonary consequences of chemical warfare agent: Sulphur Mustard: Reza Afshari, Iran
17.40 – 18.00
New insights in the management of toxic acute lung injury: Dylan de Lange, The
Netherlands
53
16.00 – 18.00
Symposium 14: Cardiovascular toxicity in drug discovery
and development
Chair: Jean-Pierre Valentin, UK
Room: Theatre Room
16.00 – 16.20
Cardiovascular toxicity: understanding the issues, challenges and opportunities:
Rashmi R. Shah, UK
16.25 – 16.45
Hazard identification and elimination: designing safe medicines: Laszlo Urban, USA
16.50 – 17.10
Integrated cardiovascular risk assessment: a balancing act between risks and benefits:
Tim Hammond, UK
17.15 – 17.35
Mitigating and managing clinical cardiovascular risks: preserving effective medicines:
Paul Volders, The Netherlands
17.40 – 18.00
Translational cardiovascular toxicity: from animal to man and back: Jean-Pierre Valentin, UK
16.00 – 18.00
Workshop 13: miRNAs: mechanisms and safety issues
Chairs: Nancy Claude, France and Catherine de la Moureyre-Spire, France
Room: Ball Room
16.00 – 16.20
Non-coding RNA mechanisms and biomarkers of toxicity: from tissue to circulation:
Jonathan Moggs, Switzerland
16.25 – 16.45
Analysis of the expression, maturation and functioning of microRNAs in cancer: Jörg
Hoheisel, Germany
16.50 – 17.10
MicroRNAs as markers of drug-induced tissue perturbation and adaptation: Christopher
Goldring, UK
17.15 – 17.35
The role of microRNAs in the response to toxic insult: Martin Bushell, UK
17.40 – 18.00
The HESI inter-laboratory miRNA Project: Catherine de la Moureyre-Spire, France
54
16.00 – 18.00
Workshop 14: Addressing safety in the immature organism:
about children’s safety and risk-assessment
Chairs: Jacqueline Carleer, Belgium and Georg Schmitt, Switzerland
Room: Brünig 1–3
This Workshop is co-sponsered by Sequani Limited, UK.
16.00 – 16.25
Introduction to the immature organism: Georg Schmitt, Switzerland
16.30 – 16.55
Non-clinical safety in paediatric drug development: Jim Ridings, UK
17.00 – 17.25
Juvenile safety testing for chemicals and pesticides: Aldert Piersma, The Netherlands
Tuesday
September 3rd
17.30 – 17.55
Value of studies in juvenile animals for human risk assessment: John DeSesso, USA
16.00 – 17.30
Oral Session 5: Genotoxicity, Carcinogenicity & Mechanisms
in Toxicology
Chair: Shana Sturla, Switzerland
Room: Harder 1+2
16.00 – 16.15
Dose-response of alkylation-induced colorectal carcinogenesis in MGMT-proficient
and -deficient mice: Jörg Fahrer, Germany
16.15 – 16.30
Breast cancer in danish women: A prospective case-control study on breast cancer risk
upon exposure to perfluorinated compounds: Eva Cecilie Bonefeld-Jorgensen, Denmark
16.30 – 16.45
The ToxTracker assay: Unveiling the carcinogenic properties of chemicals: Giel Hendriks,
The Netherlands
16.45 – 17.00
Noncanonical activation of ATR-p53 axis by DNA-protein crosslinks controls cell death
responses to formaldehyde: Anatoly Zhitkovich, USA
17.00 – 17.15
The role of rat and human CYP enzymes in okadaic acid-associated toxicity: Franziska
Kolrep, Germany
17.15 – 17.30
FRET-based analysis of the interaction between mEH and CYP: Anette Orjuela, Switzerland
55
Wednesday, September 4th, 2013
08.30 – 10.30
Symposium 15: Tiered approaches to assess complex
mixtures
Chairs: Heli Hollnagel, Switzerland and Martin van den Berg, The Netherlands
Room: Auditorium
This Symposium is sponsored by ECETOC.
08.30 – 08.50
Current concepts in mixture toxicology and risk assessment: Herman Autrup, Denmark
08.55 – 09.15
Testing mixtures in vivo at human-relevant exposure levels: Steffen Schneider, Germany
09.20 – 09.40
Application of the combined decision tree to surface water data from Switzerland, UK, and
other EU countries: Marion Junghans, Switzerland
09.45 – 10.05
Application of the decision tree methodology to human health endpoints for multi-constituent chemical formulations: Heli Hollnagel, Switzerland
10.10 – 10.30
Grouping approaches and the development of mechanism of action information for use in
the decision tree: Angelo Moretto, Italy
8.30 – 10.30
Symposium 16: New developments in “omics” for use in risk
assessment
Chairs: Michael Schwarz, Germany and Bennard van Ravenzwaay, Germany
Room: Theatre Room
This Symposium is sponsored by ECETOC and ECPA.
08.30 – 08.50
The challenges and opportunities to identify modes of action using toxicogenomics:
Richard Currie, UK
08.55 – 09.15
Integrating genomics into the AOP framework: Chris Corton, USA
09.20 – 09.40
The use of toxicogenomics for cancer risk identification and assessment, Jos Kleinjans,
The Netherlands
56
09.45 – 10.05
Metabolomics & REACH: quantitative biological activity relationships: Bennard van
Ravenzwaay, Germany
10.10 – 10.30
Qualitative and quantitative aspects of omics data: can we improve our risk assessment
using these technologies ? Saskia van der Vies, The Netherlands
8.30 – 10.30
Workshop 15: Translational imaging in non-clinical safety
applications
Chair: Markus Stephan-Gueldner, Switzerland
Room: Brünig 1–3
08.30 – 08.50
Magnetic resonance histology: Cool images – but who cares? Allan Johnson, USA
09.20 – 09.40
Echocardiography in non-clinical safety studies: adding value, and increasing acceptance
and application: Robert W. Coatney, USA
09.45 – 10.05
Potential of in-vivo imaging for DART assessment in primates: Gerhard Weinbauer,
Germany
10.10 – 10.30
Revolutionizing biomedical optical imaging with multispectral optoacoustic tomography
(MSOT): Vasilis Ntziachristos, Germany
8.30 – 10.30
Workshop 16: Predicting chronic toxicity to establish level
of safety concern in absence of toxicological data
Chairs: Elena Lo Piparo, Switzerland and Benoît Schilter, Switzerland
Room: Grimsel 1+2
08.30 – 08.50
Integration of in silico models to establish safety concern of food chemicals: the
ILSI-Europe proposal: Benoît Schilter, Switzerland
57
Wednesday
September 4th
08.55 – 09.15
Towards PET imaging of Kupffer cell activity: Erik de Vries, The Netherlands
08.55 – 09.15
Applying read-across for quantitative chronic toxicity prediction: Mark Cronin, UK
09.20 – 09.40
QSAR approach to predict chronic toxicity and carcinogenicity potency: state of the art:
Elena Lo Piparo, Switzerland
09.45 – 10.05
VirtualToxLab – In silico prediction of the toxic potential of drugs and chemicals: Angelo
Vedani, Switzerland
10.10 – 10.30
Potential of short-term biological assays to quantitatively predict chronic toxicity:
Alexander Tropsha, USA
11.00 – 13.00
Symposium 17: Reactive metabolites and drug toxicity:
contribution, mechanisms and novel approaches
Chairs: Nico Vermeulen, The Netherlands and Hilmi Orhan, Turkey
Room: Auditorium
11.00 – 11.25
Target organs and cellular reactivity of drug metabolites: Hilmi Orhan, Turkey
11.30 – 11.55
Reactive metabolites in drug discovery and development: approaches to risk mitigation:
Thomas Baillie, USA
12.00 – 12.25
Translational strategies for identifying chemically reactive metabolites as cause for
Adverse Drug Reactions: Nico Vermeulen, The Netherlands
12.30 – 12.55
Clinical relevance of drug bioactivation: Kevin Park, UK
58
11.00 – 13.00
Symposium 18: Nuclear receptors integrate metabolic and
environmental signals to regulate cell fate
Chairs: Ronald Tjalkens, USA and Eva Cecilie Bonefeld-Jørgensen, Denmark
Room: Theatre Room
11.00 – 11.25
Aryl Hydrocarbon receptor (AhR) regulation of inflammation and cancer: Michael Platten,
Germany
11.30 – 11.55
The orphan receptor NR4A1 (TR3/Nur77) as a drug target for cancer chemotherapy:
Stephen Safe, USA
12.00 – 12.25
Non-genomic responses of nuclear receptors to environmental signals: Xiao-kun Zhang,
China
12.30 – 12.55
Neuroinflammatory injury and NR4A receptors: Ronald Tjalkens, USA
11.00 – 13.00
Wednesday
September 4th
Workshop 17: Assessment of azo dyes and aromatic amines
in food additives, cosmetics and consumer products
Chairs: Thomas Platzek, Germany and Rex FitzGerald, Switzerland
Room: Harder 1+2
11.00 – 11.20
Overview on toxicity and exposure to azo dyes and aromatic amines: Thomas Platzek,
Germany
11.25 – 11.45
Re-evaluation of azo dyes as food additives: problems encountered: Iona Pratt, Ireland
11.50 – 12.10
Allergies and hair dyes: Wolfgang Uter, Germany
12.15 – 12.35
Metabolism of oxidative hair dyes in the skin and the organism: Gerhard Nohynek, France
12.40 – 13.00
Toxicity of non-regulated aromatic amines from azo dyes in textiles: knowns and
unknowns: Beat Brüschweiler, Switzerland
59
11.00 – 13.00
Workshop 18: Ecological risk assessment in the 21st century:
taking into account mechanistic data
Chairs: Claus Svendsen, UK and Jean-Lou Dorne, Italy
Room: Brünig 1–3
11.00 – 11.20
Using OMICS in ecological risk assessment: where do we stand? Peter Kille, UK
11.25 – 11.45
The promise of ecotoxicogenomics for detecting adverse contaminant effects in
non-model species: Inge Werner, Switzerland
11.50 – 12.10
Functional toxicogenomics in bees: recent advances towards mechanism-based risk
assessment: Reed M. Johnson, USA
12.15 – 12.35
Using OMICS technologies to unravel mechanisms of toxicity from endocrine disruptors in
aquatic species: Nancy Denslow, USA
12.40 – 13.00
Toxicokinetic interactions of chemical mixtures in ecotoxicology: critical issues: Jean-Lou
Dorne, Italy
11.00 – 13.00
Oral Session 6: Neurotoxicology, Developmental Toxicology &
miRNAs
Chair: Michael Arand, Switzerland
Room: Grimsel 1+2
11.00 – 11.15
Enhanced intranasal delivery of Gemcitabine to the central nervous system: Mansi Krishan,
USA
11.15 – 11.30
“Ecstasy” impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3ß: Félix Carvalho, Portugal
11.30 – 11.45
Effects of neurotoxic compounds on functional three-dimensional neural tissues derived
from hESCs: Luc Stoppini, Switzerland
60
11.45 – 12.00
miRNomics, metabolomics and 3D neuronal differentiation of LUHMES progenitor cells as
an in vitro model for DNT studies, Lena Smirnova, USA
12.00 – 12.15
MiRNA-210 modulates nickel-induced hypoxic responses by repressing the iron-sulfur
cluster assembly proteins ISCU1/2: Min-Di He, China
12.15 – 12.30
miRNA profiling as a tool for developmental neurotoxicity pathway analysis in human in
vitro model: Anna Price, Italy
12.30 – 12.45
Using adverse outcome pathway genes to assess developmental toxicity of compounds
in a mouse stem cell system: Marc Teunis, The Netherlands
13.10 – 14.10
Closing Ceremony
Chair: Ruth Roberts, President of EUROTOX, UK
Room: Auditorium
Wednesday
September 4th
Farewell address
Thomas Weiser, President of the EUROTOX 2013 Congress, Switzerland
Award ceremony
Ruth Roberts, President of EUROTOX, UK
Presentation of the EUROTOX 2014 Congress in Edinburgh, UK
Heather Wallace, President of the EUROTOX 2014 Congress, UK
Closing of the EUROTOX 2013 Congress
Ruth Roberts, President of EUROTOX, UK
61
Sponsor / Exhibitor-hosted Sessions
Monday, September 2nd, 2013
10.00 – 11.00
Exhibitor-hosted Session
MPI Research
Room: Grimsel 1+2
How Do I Get Into Phase 1 Trials With My Compound?
Scott Boley, USA
Once a company has selected their lead compound, the next phase is determining which
nonclinical studies need to be conducted to support taking the lead compound into the
first clinical trials. Unfortunately this question does not have a straightforward answer
since the approach taken is entirely dependent on the test article type (small molecule, biopharmaceutical, device), clinical indication (life threatening, non-life threatening), and
planned Phase I trial design (route and regimen). This presentation outlines the nonclinical
studies that should be considered in designing a strategy to support your initial IND application. Examples from small molecules to biopharmaceuticals to botanicals, oncology to
pediatric indications, will be covered. This information will provide a solid basis for understanding the numerous factors influencing the nonclinical approach needed to progress
into the clinic.
13.00 – 14.00
Sponsor-hosted Session
Evidence-based Toxicology Collaboration
Room: Grimsel 1+2
Chair: Thomas Hartung, USA
Evidence-based approaches, which were pioneered in medicine, provide the means to
transparently, objectively, and consistently assess the evidence bearing on questions in
medicine or other fields of science. The Evidence-based Toxicology Collaboration (EBTC)
was formed to translate the principles and approaches of Evidence-based Medicine/Health
Care to toxicology. The EBTC comprises stakeholders in academia, industry, and government seeking to strengthen decision-making in safety sciences, and thereby enhance confidence in the process by which scientific evidence is assessed. The EBTC is primarily interested in assessing the performance of the toxicological test methods and addressing
62
questions about the safety of substances to human health and the environment. The
EBTC’s efforts are timely, as there is growing interest in applying systematic reviews in
toxicology, which would be facilitated by a toxicology ontology, be as well as a growing
recognition that new test assessment approaches are needed, for example in the context
of composing and assessing integrated testing strategies.
13.00 – 13.20
Evidence-based Toxicology (EBT) and the EBT Collaboration: Sebastian Hoffmann, Germany
13.20 – 13.40
EBT and Integrated Testing Strategy: Thomas Hartung, USA
Sponsored
Sessions
13.40 – 14.00
Toxicology Ontology Development supporting Evidence-based Approaches in Predictive
Toxicology: Barry Hardy, Switzerland
13.00 – 14.00
Exhibitor-hosted Session
AnaPath and collaborating groups
Room: Harder 1+2
Pathology Evaluation involved in the Development of ATMPs
K. Weber, AnaPath GmbH, Oberbuchsiten, Switzerland
J. Füner, preclinics GmbH, Potsdam, Germany
S. Gähler, AnaPath GmbH, Oberbuchsiten, Switzerland
H. Hofman-Hüter, BSL Bioservice Scientific Laboratories GmbH, Planegg, Germany
O. Janke, preclinics GmbH, Potsdam, Germany
J. Lehmann, Fraunhofer Institute for Cell Therapy and Immunology, Germany
W. Riedel, BSL Bioservice Scientific Laboratories GmbH, Planegg, Germany
K. Weidemann, BSL Bioservice Scientific Laboratories GmbH, Planegg, Germany
ATMPs (Advanced Therapy Medicinal Products) consist of three major therapeutical
groups including gen therapeutics, somatic cell therapeutics, and engineered tissues. A
number of ATMPs are classified and listed under the ‘Summaries of scientific recommendations on classification of advanced-therapy medicinal products’ by the EMA. All ATMPs
contain partially or consist fully of living cells or tissues. A further option is the combination of ATMPs with medical devices. Therefore, ATMPs are complex, and the preclinical
testing differs in many aspects from ‘classical’ testing strategies.
The use of many different species including diseases models as well as the complex application of molecular biology approaches and the usage of an extended armamentarium to
trace ATMPs in vivo not alone cause changes in the way of classical pathology evaluation.
The presentation will show examples on strategies of pathology evaluation during the development of ATMPs.
63
Tuesday, September 3rd, 2013
10.00 – 11.00
Exhibitor-hosted Session
ACEA Biosciences, Inc.
Room: Grimsel 1+2
Using the xCELLigence RTCA Cardio System for Assessment of Preclinical Cardiac Safety
Assessment
Yama Abassi, USA
Here for you. for your HealtH.
Medical knowledge is our fascination. Together with our associates in research,
science and education we help millions of people all over the world.
We are committed to improving medical treatment. Because health matters!
www.sanofi.de
64
AVS 903 12 013a
Cardiac toxicity is a major concern in drug development and it is imperative that clinical
candidates are thoroughly tested for adverse effects earlier in the drug discovery process.
In this presentation we will discuss the utility of ACEA Biosciences xCELLigence RTCA Cardio System in conjunction with stem cell derived cardiomyocytes for assessment of compound risk in the drug discovery process. The system was validated using stem cell-derived
cardiomyocytes and primary cardiomycytes and by dose-response profiling of pharmacological compounds, including ion channel modulators, chronotropic/ionotropic agents,
hERG trafficking inhibitors and drugs withdrawn due to TdP arrhythmia. Our results show
this system can sensitively and quantitatively detect modulators of cardiac function, including compounds missed by electrophysiology. Our key finding is that pro-arrhythmic
compounds produce signature profiles that reflect arrhythmia and can be used for identification of other pro-arrhythmic compounds. The time series data can be used to identify
compounds which induce arrhythmia by complex mechanisms such as hERG trafficking inhibition. Microelectronic monitoring of stem cell derived cardiomyocyte beating provides
a high throughput, quantitative and predictive assay system that can be used for assessment of cardiac liability earlier in the drug discovery process.
12.00 – 13.00
Sponsored
Sessions
Exhibitor-hosted Session
Huntington Life Sciences
Room: Brünig 1–3
3Rs: refinement techniques for Primates and their effect on data quality
Helen Palmer, UK
There is no doubt that over the last 20 years the state of housing and husbandry for primates in research premises has improved enormously throughout Europe. In our attempts
to improve the welfare and wellbeing of our animals we must constantly remind ourselves
that fulfilling the scientific objectives of the study is paramount, otherwise there is no justification for use of the primate at all. In this session we will review techniques and equipment originally implemented as welfare improvements, and show how the data produced
is of higher quality because of these changes. The effect of some of these welfare improvements, including group housing, positive reinforcement training, restraint free measurement techniques and microsampling will be examined with regards to safety pharmacology and toxicology studies. The state of animal welfare in laboratories is in a state of
continual improvement; in this session we will discuss just how worthwhile these improvements are.
65
A new direction
for European crop protection
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Learn more, engage:
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ecpa.eu
ecotox_conference_advertorial.indd 1
01/07/2013 15:52:36
Posters
Monday, September 2nd, 2013
Location:
Auditorium Foyer: P01/01 – P03/14; P06/01 – P09/25; P11/01 – P11/16
Concert Hall: P04-01 – P04/14; P10/01 – P10/24; P15/01 – P17/18
Club Casino: P05/01 – P05/23
Auditorium Foyer
P01: Biologics
P01-01
Elaeocarpus Petiolatus Ethanol Extract Inhibits Asthmatic Activity on OVA-Induced Mouse
Model of Airway Inflammation
Cho, Eun-Sang, Lee, Kyoung-Youl, Lee, Mee-Young, Son, Hwa-Young
P01-02
Implication of HSF1-mediated heat stress response in adaptive induction of metallothioneins in mammalian cells contacting with toxic heavy metal ions
Demidkina, Anna; Kabakov, Alexander
P01-03
Non-clinical safety evaluation of AAV5-PBGD in mice and cynomolgus macaques
Gloria González-Aseguinolaza, Astrid Pañed, Esperanza López-Franco, Cristina Olagüe, Antonio
Fontanellas, Carmen Unzu, Ana Sampedro, María Eugenia Cornet, María del Mar Municio, Paul Heal,
Harald Petry, Marc Sonnemans, Lisa Spronck, Florence Salmon
Bart A Nijmeijer, PhD, Harald Petry, PhD, Marc A Sonnemans, Stuart G Beattie PhD, Lisa Spronck
Florence Salmon, PhD, Hans Preusting, PhD, Arie Van Oorschot, PhD and Jaap Twisk, PhD
P01-05
The sub-lethal toxic effects and bioconcentration of the human pharmaceutical atenolol in
rainbow trout (Oncorhynchus mykiss)
Christoph Steinbach, Viktoriia Burkinaa, Ganna Federovav, Katerina Grabicova, Josef Velisek, Vladimir
Zlabek, Tomas Randak, Heike Schmidt-Posthaus, Roman Grabic, Hana Koccour Kroupova
P01-06
Risk of mood disorders in subjects who began smoking in adulthood versus early
­adolescence
Aziez Chettoum, Rachid Mosbah, Hacene Frih
67
Posters
P01-04
Safe and efficacious delivery of the human clotting factor IX gene to non human primates
using a recombinant AAV vector produced in a fully-scalable GMP-compliant production
system.
P02: Biomarkers
P02-01
28 Days oral exposure to moniliformin does not influence on 8-OHdG levels in SD-rat urine
Pertti Koivisto, Martina Jonsson, Alexis Nathanail, Marika Jestoi, Kimmo Peltonen
P02-02
Assessment of genotoxic and oxidative effects in workers of a fibreglass reinforced plastic
industry exposed to styrene
Cavallo, Delia; Tranfo, Giovanna; Ursini, Cinzia L.; Fresegna, Anna Maria; Ciervo, Aureliano; Maiello,
Raffaele; Gherardi, Monica; Paci, Enrico; Iavicoli, Sergio
P02-03
Association between Inflammatory Marker, Environmental Lead Exposure, and
Glutathione S-Transferase gene
Jintana Sirivarasai, Winai Wananukul, Sming Kaojarern, Suwannee Chanprasertyothin, Nisakron
Thongmung, Wipa Ratanachaiwong, Thunyachai Sura, and Piyamit Sritara
P02-04
Changes in Blood Antioxidant Status in Humans during Occupational Exposure to Coal
Fly Ash (CFA)
Lulzim Zeneli, Majlinda Ajvazi, Martina Piasek, Jasna Jurasović, Leonard Kurti, Hidajet Paçarizi,
Nexhat Daci
P02-05
Comparative study between apoptotic and proliferative markers in dexamethasonedependent and physiological thymic atrophy in cattle.
G.B.Richelmi, C.Maurella, M. Pezzolato, D. Longo, S. Meistro, E. Bozzetta
P02-06
Comparison of Two Commonly Used Rat Strains for Preclinical Toxicity Testing on
Predictive Biomarkers for Nephrotoxicity after Cisplatin Treatment
Kunze M, Weber K, Schuster I, Meier S, Leoni AL
P02-07
Contamination of white cheese with aflatoxin M1
Ortiz-Martinez, Raul; Valdivia-Flores, Arturo; Quezada-Tristan, Teodulo; De Luna-López, Carolina
P02-08
Cytogenetic alterations in Formaldehyde exposed workers measured in a target and
distal tissue.
Solange Costa, Carla Costa, Susana Silva, Patrícia Coelho, Beatriz Porto, João Paulo Teixeira
P02-09
Determination of n-hexane metabolite 2, 5-hexanedione in human urines by on-line
solid-phase extraction coupled with LC-APCI-MS/MS
Shi-Nian Uang, Kuen-Yuh Wu
P02-10
Determination of Polycyclic Aromatic Hydrocarbons (PAHS) in Fish and Shellfish Samples.
Risk Assessment for the Consumers.
Gil F, Olmedo P, Hernández AF, Pla A, Molina-Villalba I
P02-11
Determination of Toxic Elements (Hg, Cd, Pb, Sn and As) in Fish and Shellfish Samples.
Gil F, Olmedo P, Pla A, Hernández AF, Molina-Villalba I
68
P02-12
Discovery of biomarkers of dioxin intoxication in human urine: analysis by metabolomics
and biologically-driven strategy
Julien Boccard, Fabienne Jeanneret, Olivier Sorg, Jean-Hilaire Saurat, Stepanka Vlckova, Daniela
Pelclova, Douglas N. Rutledge, Denis Hochstrasser, Serge Rudaz
P02-13
Diurnal levels of the Type II collagen neopitope (TIINE) biomarker for collagen breakdown
in dogs
Kai Schaefer, Helga Lorenz, Nils Boehm, Stephanie Fischmann, Candace Graff, and Katja Hempel
P02-14
Evaluation of certain oxidative stress, endothelial dysfunction and inflammation parameters in Alzheimer disease patients under conventional treatment
Gubandru, Miriana; Margina, Denisa; Tsitsimpikou, Christina; Ilie, Mihaela; Tsatsakis, Aristidis Michael;
Kouretas, Demetrios
P02-15
Hair arsenic concentrations of residents living in Nevsehir province, Turkey
Beril Altun, Nusret Ertas, Usama Alshana, N. Deniz Hisarli, Elif Asik, Gonca Cakmak Demircigil
Ela Kadioglu, Celalettin R. Celebi, Esref Atabey, O. Yavuz Ataman, Hakan Serce, Nazmi Bilir,
A. Murat Tuncer, Sema Burgaz
P02-16
Multi-laboratory assessment of best practices for quantification of microRNAs associated
with isoproterenol-induced myocardial injury in the urine and plasma of rats
KL Thompson, T Chen, P Couttet, H Ellinger-Ziegelbauer, M Kanki, J Kelsall, E Boitier, R Nassirpour,
G Searfoss, T Sharapova, C de la Moureyre-Spire, P Yuen, and R O’Lone
P02-17
Pharmacogenomic Studies and Quantification of Tramadol and M1 in Human Post Mortem
Samples
Isabel Costa, Ana Oliveira, Paula Guedes de Pinho, Félix Carvalho, Ricardo Jorge Dinis-Oliveira
P02-18
Plasma lactate level may be an insufficient monitoring tool in critically ill patient: A case of
ischemia modified albumin in acute glyphosate poisoning
Posters
Choi, Byungho; Sohn, Changhwan; Ryoo, SeungMok; Ha, Sangwook; Jung, Rubi; Lim, Kyoungsoo;
Oh, Bumjin
P02-19
Probing the in vitro antiatherosclerotic outcome of some polyphenols
Margina, Denisa; Bacanu, Claudia; Gradinaru, Daniela; Ilie, Mihaela; Neagoe, Ionela; Manda, Gina
P02-20
Serum pregnancy-associated plasma protein A (PAPP-A) levels in type 2 diabetes mellitus
patients with normoalbuminuria and microalbuminuria
Ali Mohammadi Karakani
P02-21
Synthetic glucocorticoids in bovine urine: from targeted to untargeted detection
Elena Bozzetta, Danilo Pitardi, Barbara Cini, Maurizio Paleologo, Abram Brouwer, Peter Behnisch,
Marco Vincenti, Pierluigi Capra, Marilena Gili, Marzia Pezzolato, Daniela Meloni
69
P02-22
The impact of xenobiotic metabolizing enzyme polymorphisms on cytogenetic biomarkers
in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons
Iscan, Mumtaz; Ada, Ahmet O.; Demiroglu, Canan; Yilmazer, Meltem; Suzen, Sinan H; Demirbag, Ali E.;
Efe, Sibel; Alemdar, Yilmaz; Burgaz, Sema
P02-23
Trace determination of 13 antineoplastic drugs in urine: a new ultra-performance liquid
chromatography/tandem mass spectrometry method for assessing exposure of hospital
personnel
Giovanni Fabrizi, Marzia Fioretti, Lucia Mainero Rocca
P02-24
Use of cytotoxicity-based assays in the in vitro diagnosis of patients with Sevens-Johnson
syndrome
Pecaric Pekovic, Tatjana; Porebski, Gregory; Bosak, Marek; Kawabata, Tom; Pichler, Werner J.
P02-25
Use of lung gene expression profiles to determine exposure to oxidative stress-related
constituents during cigarette smoke exposure in rodents
Fariss, Marc; Guo, Yin; Scian, Mariano; Edmiston, Jeffery
P03: Carcinogenesis
P03-01
5-Demethyltangeretin (5-DTAN) is more effective than tangeretin in 7, 12-dimethylbenz[a]
anthracene (DMBA)/12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin
carcinogenesis
Min-Hsiung Pan, Chieh-Han Chung, and Chi-Tang Ho
P03-02
Breast Cancer in Danish women: A prospective case-control study on breast cancer risk
upon exposure to perfluorinated compounds
Eva Cecilie Bonefeld-Jorgensen, Manhai Long, Stine F. Overvad, Jørn Olsen
P03-03
Carcinogenicity testing of Eliglustat in the mouse and rat
Dagher, Rafif; Marquis, Judith; Watzinger, Malene; Forster, Roy
P03-04
Cigarette sidestream smoke is a source of environmental estrogen
Lih-Ann Li, Lun-Cheng Kuo, Chun-Ju Lin, and Pei-Rung Wu
P03-05
Combined effect of the SOD mimic MnTnHex-2-PyP5+ and doxorubicin on the migration
and invasiveness of breast cancer cells
A.S. Fernandes, A. Flórido, M. Cipriano, I. Batinic-Haberle, J. Miranda, N. Saraiva, P.S. Guerreiro,
M. Castro, N.G. Oliveira
P03-06
Deregulation of benzo[a]pyrene metabolism in lung epithelial cells under inflammatory
conditions
Vondracek, Jan; Smerdova, Lenka; Neca, Jiri; Svobodova, Jana; Topinka, Jan; Schmuczerova, Jana;
Kozubik, Alois; Machala, Miroslav
70
P03-07
Dose-response of alkylation-induced colorectal carcinogenesis in MGMT-proficient and
-deficient mice
Fahrer, Jörg; Frisch, Janina; Nagel, Georg; Reißig, Sonja; Waisman, Ari; Samson, Leona D.; Kaina, Bernd
P03-08
Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through
down-regulation of hydrogen-peroxide mediated focal adhesion kinase and the paxillin
signaling pathway
Li-Ching Chen, Chih-Hsiung Wu, Wen-Sen Lee, and Yuan-Soon Ho
P03-09
Inhibition of canonical Wnt signaling deregulates expression of CYP1A1 in colon cancer
cells
Kabatkova, Marketa; Machala, Miroslav; Topinka, Jan; Kozubik, Alois; Vondrácek, Jan
P03-10
Oxidation of carcinogenic benzo[a]pyrene by human and rat CYP1A1 and its influencing by
cytochrome b5 – a comparative study
Indra, Radek; Moserova, Michaela; Sulc, Miroslav; Stiborova, Marie
P03-11
P38 kinase regulates cytochrome P450 1B1 under inflammatory conditions
Šmerdová, Lenka; Kohoutek, Jirí; Machala, Miroslav; Vondrácek, Jan
P03-12
Prooxidant and anticarcinogenic effect of non-pigmented and pigmented rice bran
extracts on human colon cancer cell line
Chunhabundit, Rodjana; Kongkachuichai, Ratchanee; Srisala, Supanart; Jittorntrum, Bunyada;
Visetpanit, Yupin
P03-13
Quantitative Analysis on HeLa Engrafting Ability in NOG Mice
Urano, Koji; Machida, Kazuhiko; Kusakawa, Shinji; Sawada, Rumi; Yasuda Satoshi, Ito, Mamoru;
Tsutsumi, Hideki; Sato, Yoji
Adiguzel, Zelal; Baykal, Tarik; Cetin, Yuksel; Kacar, Omer; Serhatli, Muge; Polat, Hivda; Ulukaya, Engin;
Yilmaz, Veysel T.; Acilan, Ceyda
P06: Consumer’s Protection
P06-01
Acute and short term impact of active and passive tobacco and electronic cigarette smoking on inflammatory markers
Manolis N. Tzatzarakis, Kyriakos I. Tsitoglou, Maria S. Chorti, Konstantina P. Poulianiti, Athanasios Z.
Jamurtas, Yiannis Koutedakis, Andreas D. Flouris, Kyriakakis Michalis, Tsatsakis Aristidis
P06-02
Applicability of a Clinical Protocol Security to assess the Ocular Irritation of rinse-off
children’s cosmetics.
Paes, Cintia; Queiroz, Diana; Fragoso, Meire; Martin, Fabiana; Azevedo, Keller; Mosca, Mariane; Guerra,
Lucas; Rosa, Vivian; Rocha, Bianca
71
Posters
P03-14
In vitro and in vivo evaluation of the toxicological and molecular effects of a novel Pd(II)
complex
P06-03
Obese and normal mice differ in enzyme activities of cytochromes P450 after administration of green tea extract
Anzenbacher, Pavel; Jourová, Lenka; Kolárová, Veronika; Bártiková, Hana; Bousová, Iva; Anzenbacherová, Eva
P06-04
Quantitative risk assessment for skin sensitization: a simplified approach for hair dye
ingredients?
Carsten Goebel, Thomas Diepgen, Maya Krasteva, Harald Schlatter, Jean-Francois Nicolas, Brunhilde
Blömeke, Pieter Jan Coenraads, Axel Schnuch, James S. Taylor, Jacquemine Pungier, Rolf Fautz,
Anne Fuchs, Werner Schuh, G. Frank Gerberick, Ian Kimber
P07: Drug oriented Toxicological Research
P07-01
7-Hydroxydehydronuciferine induces human melanoma A375.S2 cell death via autophagy
and apoptosis in vitro and in vivo investigations
Hui-Min Wang and Pei-Fang Wu
P07-02
A modified oral UV-LLNA in Balb/c mice to investigate phototoxicity mechanisms and
pharmacokinetic properties in skin
Stéphanie Boudon, Martin Schneider, Gregory Morandi, Ursula Junker, Ulla Plappert, Alex Odermatt,
Daniel Bauer.
P07-03
A New Organotypic 3-D Small Intestinal Tissue Model Reconstructed from Primary Human
Cells
Ayehunie, Seyoum; Stevens, Zachary; Landry, Timothy; Armento, Alexander; Klausner, Mitchell;
Hayden, Patrick
P07-04
Acetaminophen-glutathione conjugate: a possible role in acetaminophen toxicity
Rousar, Tomas; Nydlova, Erika; Kucera, Otto; Cesla, Petr; Vrbova, Martina; Cervinkova, Zuzana
P07-05
Acute and repeated dose toxicity studies of novel pyridazine substituted s-triazin-2-imine/
one/thione derivatives as new class of antihypertensive agent
Ravinesh Mishraa, Anees A Siddiquib, Asif Husainb, Mohd Rashidb, Sameya Anjumc
P07-06
Antidiabetic and antioxidant activity of pheophorbide a from Capsosiphon fulvescens
extract in streptozotocin-induced diabetes in rats
Kwang-Won Lee, Ji Sun Oh, Chung-Oui Hong, Mi-Hyun Nam
P07-07
Antinociceptive Effects of Avocado Leaf Extracts (Persea americana) on Rats
Abubakar, M. G. and Adamu, L
P07-08
Aryl hydrocarbon receptor (AhR)-mediated induction of CYP1A1 in human hepatocytes by
furanochromones visnagin and khellin
Radim Vrzala, Thomas Haarmann-Stemmannb, Katrin Frauensteinb, Zdenek Dvoraka
72
P07-09
Cardiac Lesions Induced by Testosterone in Rats
Melik Seyrek, Eda Emer, Bulent Kurt, Oguzhan Yildiz, Enis Macit, Ahmet Sayal
P07-10
Cardiotoxic Effect of Concomitant versus Sequential Trastuzumab with Thoracic Radiotherapy: An Echocardiographic Study in Rats
Oguzhan Yildiz, Melik Seyrek, Sait Demirkol, Guler Yavas, Melis Gultekin, Ferah Yildiz
P07-11
Cardiotoxic Effect of Subacute High Dose Testosterone and Dehidroepiandrosterone
Administration: An Echocardiographic Study in Rats
Eda Emer, Sait Demirkol, Oguzhan Yildiz, Melik Seyrek, Enis Macit, Ahmet Sayal
P07-12
Comparison of Antioxidant Activities of Newly Synthesized Melatonin Analogues
Senem Ozcan, Duysal Uslu, Çigdem Karaaslan, Hanif Shrinzadeh, Sibel Suzen, Hande Gurer-Orhan
P07-13
Determination of antibodies to cocaine metabolites in serum of cocaine users
Elena Vakonaki, Vitalia S. Morozova, Svetlana N. Petrochenko, Oksana Yu. Polyvanaya, Marina A.
Myagkova, Matthaios Kavvalakis, Kovatsi Leda, Manolis N. Tzatzarakis, Aristidis M. Tsatsakis
P07-14
Effect of Acetic Zinc on Phospholipid Composition of Rat Liver Cell Plasmatic Membranes
under Chronic Alcohol Intoxication
Kharchenko, Olga; Bogun, Larisa; Ostapchenko, Lyudmyla
P07-15
Effect of APE1 Inhibitors on the Cytotoxicity and Genotoxicity of Doxorubicin in
MDA-MB-231 Cells
P.S. Guerreiro, J.P. Miranda, A.S. Fernandes, J.G. Costa, M. Castro, and N.G. Oliveira
P07-16
Encapsulation of cisplatin by cucurbit[7]uril decreases the neurotoxic and cardiotoxic side
effects of cisplatin.
Rabbab Oun, Jane Plumb, Edward Rowan and Nial Wheate
Mansi Krishan, Gary Gudelsky, Pankaj Desai, Mary Beth Genter
P07-18
Evaluation of Hydroxypropyl-Beta-Cyclodextrin (HPβCD) as formulation vehicle for use in
general toxicity studies in mice
Glojnaric, Ines; Cuzic, Snjezana; Markovic, Darko
P07-19
Hair analysis of sedative-hypnotics drugs involved in crime suspected cases in Greece
Manolis N. Tzatzarakis, Christina Tsitsimpikou, Xenofon Mandakas, Elena Vakonaki, Matthaios
P. Kavvalakis, Theodoropoulou Eleutheria, Katerina Kanaki, Leda Kovatsi, Aristidis M. Tsatsakis
P07-20
Integrin receptor seeking bio-engineered “smart” magnetic nanomaterials in Lewis lung
carcinoma toxicity studies
Monika A. Cywinska, Ireneusz P. Grudzinski, Anita Kosmider, Magdalena Poplawska, Michal Bystrzejewski, Andrzej Cieszanowski, Zbigniew Fijalek, Agnieszka Ostrowska
73
Posters
P07-17
Enhanced Intranasal Delivery of Gemcitabine to the Central Nervous System
P07-21
Iron sucrose nanoparticles: effects on tissue iron levels and hepatic gene expression in
the rat
Forster, Roy; Bouchard, Johanne; Jaillet, Léonore; Rogue, Alexandra; Pearson, Nick; Elford, Peter
P07-22
Phytochemical and Acute Toxicity Studies on Salvadora Oleoides Decne
Manu Arora, Anees A Siddiqui, Sarvesh Paliwal, Manav Malhotra, Manbir Kaur
P07-23
Promising Effects of Intravenous Lipid Emulsion as an Antidote in Acute Tramadol
Poisoning
Maryam Vahabzadeh and Hosein Hoseinzadeh
P07-24
Quantification Of Impurities In Commercial Drug Products Containing Montelukast And
Evaluation Of The Impurities’ Cytotoxic Effects
Emerce, Esra; Cok, Ismet; Degim, Ismail Tuncer
P07-25
Rapid Toxicity and Drug Delivery Screening in an In Vitro Human Airway Model
Jackson, George; Armento, Alexander; Letasiova, Silvia; Klausner, Mitchell; Hayden, Patrick
P07-26
Stereospecific cardiotoxicity evaluation of local anesthetics using their discriminable
interactions with biomimetic chiral membranes
Hironori Tsuchiya, Maki Mizogami
P07-27
Synthesis of benzimidazoles bearing oxadiazole and triazolo-thiadiazoles nucleous: As new
anticancer agents
Mohd Rashid, Asif Husain, Ravinesh Mishra, Sameya Anjum
P07-28
The effects of selected cytostatics and their mixtures on aquatic primary producers
Polona Brezovšek, Tina Eleršek, Metka Filipič
P07-29
The Mutagenic Potential Assessment of the Major Impurity of Hypertension Drug
Hydrochlorothiazide
Cok, Ismet; Emerce, Esra; Sari, Sibel; Bostanci, Omur
P07-30
The Occurence of Risk Variant Alleles TPMT in the Czech and Slovak Population
Kolorz, Michal; Bartosova, Ladislava; Wroblova, Katerina; Bartos, Milan; Ulicny, Boris
P07-31
Toxicological effect of dexamethasone treatment on the transport of both amino-acids,
Tyrosine and Tryptophan, across the blood brain barrier (BBB)
Aouichri, Mohamed
P07-32
What Would Genetic Polymorphisms in the Dopamine-2-Receptor (DRD2) and Serotonin
Transporter Gene (SERT) Tell us about Vulnerability to Comorbid Drug Abuse and
Cardiovascular Risks among Egyptian Population?
Taalab, Yasmeen; Puls, Imke; Heinz, Andreas; El-Haggar, Mohamed; Ghanem, Abdel-Aziz; Abdel-Wahab,
Doaa; Gad, Seham
74
P07-33
Zebrafish as a complementary model in toxicology
Simon Folkertsma, Cyrille Krul, André Wolterbeek, Anna Beker, Cor Snel, Aswin Menke and Didima de
Groot
P07-34
Effect on QT interval after treatment with moxifloxacin in 2 and 8 week old juvenile
Beagle dogs
Maaike Peschar, Ph.D., Nicky Lourens, M.Sc., Kevin Scase, M.Sc., Dick Schoutsen, M.Sc., Han Tielemans,
Harry Emmen, M.Sc.
P08: Environmental Toxicology
P08-01
Acute and Chronic Metal (Cd, Pb) Exposures Alter Red Blood Cell ATPase activity in
Freshwater Fish (Oreochromis niloticus)
Gülüzar Atli, Ali Eroğlu, Zehra Doğan, Esin G. Kanak, Kadir Kocalar, Mustafa Canli
P08-02
Acute Cu Effects on Antioxidant System Response in the hepatopancreas of Freshwater
Snail Lymnaea stagnalis
Gülüzar Atli, Martin Grosell
P08-03
Administration of very low doses of water pharmaceutical contaminants in lean and obese
mice disturbs the hepatic expression of genes involved in circadian rhythm
Sébastien Anthérieu, Dounia Menouer, Karima Begriche, Cédric Coulouarn, Marie-Anne Robin,
Bernard Fromenty
P08-04
Age Dependent and Brain Region Specific Perturbations in Mitochondrial Enzymes
Following Exposure to Lead and Manganese in Rats
D. Chand Basha, V. Kavitha, and G. Rajarami Reddy
Polichetti, Giuliano; Capone, Domenico; De Sio, Alessandra; Polichetti, Raffaele; Attianese, Carolina;
Gentile, Antonio
P08-06
Different adverse health effects and seasonal variations of particulate matter.
Polichetti, Giuliano; De Sio, Alessandra; Gentile, Antonio; Polichetti, Raffaele; Capone, Domenico
P08-07
Biological effects of nanoparticles of silver, gold, TiO2 and nanoporous silica to selected
invertebrate species and bacteria: FP7 project NanoValid.
Olesja Bondarenko, Angela Ivask, Aleksandr Käkinen, Villem Aruoja, Irina Blinova, Katre Juganson,
Kaja Kasemets, Kai Künnis-Beres, Imbi Kurvet, Monika Mortimer, Mariliis Sihtmäe and Anne Kahru
P08-08
Cadmium exposure, inter-cellular adhesion molecule-1 and peripheral artery disease in a
longitudinal study of elderly women. A cohort and an experimental study.
Barregard, Lars; Bergstrom, Goran; Boren, Jan; Fagerberg, Bjorn
75
Posters
P08-05
Ambient air pollution (AAP) and mental disorders: future perspectives.
P08-09
Can Zn supplementation mitigate Cd-induced bioelements disturbances in liver and kidneys?
Bulat, Zorica; Ðukic-Cosic, Danijela; Buha, Aleksandra; Bulat, Petar; Matovic, Vesna
P08-10
Chronic cytotoxicity and genotoxicity of low doses of environmental contaminants in
human HepaRG hepatocytes.
Karine Rondel, Carine Lambert, Sophie Martinais, Vincent Caumette, Rémy Le Guevel, Marie-Anne
Robin.
P08-11
Combined effects of microbial toxins and structural components on the expression of
proinflammatory cytokines TNFα and IL-1β in vitro
Merja Korkalainen, Arja Moilanen, Hannu Komulainen, Matti Viluksela,
P08-12
Combined exposure of Japanese quails to cyanotoxins, Newcastle virus and lead: metallothioneins, accumulation and distribution of toxins
Kovacova V., Osickova J., Adamovsky O., Bandouchova H., Hilsherova K., Sedlackova J., Vitula F.,
Machat J., Mlcakova V., Kizek R., Adam V., Pikula J.
P08-13
Cytotoxicity evaluation of environmental chemicals via free radical detection using newly
technique immuno-spin trapping, In-Cell Western and confocal microscopy
Yuya Horinouchi, Fiona A. Summers, Marilyn Ehrenshaft, Hitoshi Houchi, Toshiaki Tamaki, Kazuo
Minakuchi, and Ronald P. Mason
P08-14
Cytotoxicity, oxidative stress and inflammatory responses induced by fly ash particles in
human lung epithelial cells
A. Forgiarini and M. Carrara
P08-15
Determination of Bisphenol A exposure in rural and urban area populations in Mersin City,
Turkey
Battal D, Cok I, Unlusayin I, Aktas A, Tunctan B
P08-16
Determination of Ni, Cr, Fe and Mn in hair from orthodontics patients by Atomic Absorption Spectrometry.
Cameán AM, Martín-Cameán A, Molina-Villalba I, Jos A, Iglesias A, Solano JE, Gil F
P08-17
Effects of a Depuration Period on the Biochemical Alterations Induced by Repeated Doses
of A. Ovalisporum Cells in Tilapias (O. Niloticius)
Cameán AM, Ríos V, Guzmán-Guillén RS, Moreno I, Prieto AI, Vasconcelos V,
P08-18
Validation of a Method to Quantify in Ni, Cr, Co and Cu in Oral Mucosa Cells by Inductively
Coupled Plasma Mass Spectrometry
Cameán AM, Martín-Cameán A, Jos A, Calleja A, Gil F, Iglesias A, Solano E.
P08-19
Development of a method for Titanium, Vanadium and Zirconium determination in oral
mucosal cells by ICP-MS: intra-laboratory assessment of its accuracy by using validation
standards
Jos A, Martín-Cameán A, Calleja A, Iglesias A, Solano E, Gil F, Cameán AM
76
P08-20
Development of an alternative testing strategy for the fish early life stage test for predicting chronic toxicity
Lucia Vergauwen, Ronny Blust, Hilda Witters, Sandra Verstraelen, Daniel L. Villeneuve, Gerald T.
Ankley, Dries Knapen
P08-21
Effect of fluoroquinolones on the avian embryonic development and hatchability of chicks
Skochova Hana, Osickova Jitka, Pikula Jiri, Bandouchová Hana, Kral Jiri, Ondracek Karel, Kovacova
Veronika
P08-22
Effect of magnesium pretreatment on cadmium-induced oxidative stress in mice
Ðukic-Cosic, Danijela; Bulat, Zorica; Buha, Aleksandra; Matovic, Vesna
P08-23
Effects of di(2-ethylhexyl)-phthalate alone or in combination with 17β-estradiol on expression of RXRalpha and RXRbeta retinoid X receptor subtypes in the MCF-7 breast cancer
cell line
Macejová D., Bialešová L., Havránek T., Brtko J., Ficková M.
P08-24
Effects of Different Endocrine Disruptor (EDC) Mixtures on Gene Expression in Neonatal
Rat Brain Regions: Focus on Developing Excitatory Synapses
Lichtensteiger, Walter; Bassetti-Gaille, Catherine; Faass, Oliver; Boberg, Julie; Christiansen, Sofie;
Hass, Ulla; Kortenkamp, Andreas; Schlumpf, Margret
P08-25
Effects of endocrine disruptors Bisphenol A and di(2-ethylhexyl) phthalate in a combination with 17 β-estradiol on apoptosis-related genes in the MCF-7 breast cancer cell line
Mlynarcikova, Alzbeta; Havranek, Tomas; Fickova, Maria
P08-26
Effects of Formaldehyde exposure on human epithelial cells all along the respiratory tract
Gaëlle Bardet, Charles Persoz, Thomas Loret, Isabelle Momas, Sophie Achard, Nathalie Seta
Lee, Kyoung-youl; Choi, Eun-young
P08-28
Ellagic acid protects against cyclophosphamide induced acute lung injury in Wistar rats by
inhibiting oxidative stress, NF-kB activation and inflammatory cell production.
Saba (author) and Sheikh Raisuddin co-author
P08-29
Endocrine disruptor Bisphenol A toxicity study in testicular mitochondria of Swiss albino
mice
Sameya Anjum and Sheikh Raisuddin
P08-30
Heavy metal burdens of public primary school children in Ibadan north-west local government area, Nigeria related to playground soils and classroom dusts
Ademuyiwa O., Akinwunmi F., Atobatele Z., Adewole O., Odekunle K., Arogundade L. and Odukoya O.O.
77
Posters
P08-27
Effects of maternal exposure to di(2-ethylhexyl)phthalate (DEHP) during pregnancy on
neonatal asthma susceptibility
P08-31
Hypothalamic-pituitary-adrenal axis activity is modified by perfluorooctane sulfonate
(PFOS) exposure in adult male rat
Lafuente, Anunciacion; Pereiro, Natividad; Gomez-Limia, Lucia
P08-32
In vitro particulate matter toxicity relates to seasonal variability in chemical composition.
Osornio Vargas, Alvaro; Manzano-Leon, Natalia; Quintana-Belmares, Raul; Sanchez, Brisa; Sitarik, Alexandra; Serrano, Jesus; Vega, Elizabeth; Vazquez-Lopez, Ines; Rojas-Bracho, Leonora; Lopez-Villegas, Tania;
Vadillo-Ortega, Felipe; De Vizcaya-Ruiz, Andrea; Rosas, Irma; Moran-Pineda, Marina; O’Neill, Marie
P08-33
Influence of media and N:P ratios on growth, microcystin production and gene expression
of a Microcystis aeruginosa strain
Bortoli, Stella; de Oliveira Silva, Diogo; A. Volmer, Dietrich; Pinto, Ernani
P08-34
(Cancelled)
P08-35
Lack of Association Between Serum Prolactin and Lead Exposure
Aysegul Bacaksiz, Meside Gunduzoz, Sedat Abusoglu, Engin Tutkun, Hinc Yilmaz, Nilgun Giynas,
Emine Gul Aydin
P08-36
Mercury Levels in Placentas from Non-Exposed Mothers
Tülin Söylemezoğlu, Zeliha Kayaaltı, Seda Kaya, Vugar Ali Türksoy
P08-37
Mercury-Resistant Bacteria from Tagus Estuary – Characterization and Mercury Reduction
Potential
Neusa L. L. Figueiredo, João Canário, Aida Duarte and Cristina Carvalho
P08-38
Neurobehavioral Effects of Exposure to Environmental Chemicals and Caesium in
Developing Offspring Mice
Isabel Llovet, Daisy Lafuente, Sergio Gonzalo, Montserrat Bellés, José Luís Domingo, Victòria Linares
P08-39
NOEC versus EC10, reloaded on a recent show case
Jung, Eunsoo; Wess, Ralf Arno; Schmidt, Thomas
P08-40
Oatp Expression profile in Danio rerio upon Microcystin-exposure
Steiner, Konstanze; Karner, Tim; Dietrich, Daniel
P08-41
Oxidative stress in birds: Effects of heavy metals and pharmaceuticals
Osickova J., Kovacova V., Pikula J., Bandouchova H., Kral J., Skochova H., Pohanka M., Novotny L.
P08-42
Particulate matter emissions from cigarettes under real life condition
Marik Gerecht, Daniel Müller, Johannes Schulze, David A Groneberg
P08-43
Protective effects of N-acetyl cysteine with zinc and selenium on chronic mercury induced
oxidative stress and DNA damage evaluation in rats.
Deepmala Joshi and Deepak Kumar Mittal
78
P08-44
Pulmonary cytotoxic in vitro studies of selected short-chain monocarboxylic acids present
in indoor environments
D. Lipsa, C. Cacho, P. Leva, J. Barrero-Moreno
P08-45
Reconstituted human airway epithelium 3D-model to assess the impact of indoor air
pollutants on the inflammatory response.
Grellet, Sophie; Momas, Isabelle; Seta, Nathalie; Bardet, Gaëlle; Achard, Sophie
P08-46
Reduced expression of genes for nuclear receptors RXRalpha and RXRbeta by bisphenol
A in human mammary cancer cells (MCF7).
Fickova M., Havranek T., Brtko J., Macejova D.
P08-47
Selected organotin halides: Toxicity versus nuclear retinoic acid/retinoid X receptors and
their co-regulators expression in breast cancer and leukemia cell lines
Brtko, Julius; Macejova, Dana; Bialesova, Lucia; Fickova, Maria; Bohacova, Viera; Sulova, Zdena; Breier,
Albert; Hunakova, Luba
P08-48
Studies on the red grape extract supplementation against mercuric chloride induced toxicity in rat erythrocytes
Kanti Bhooshan Pandey and Syed Ibrahim Rizvi
P08-49
Study of platinum group metals effects on lettuce plants (Lactuca sativa)
Mikulaskova, H., Nemcova, B., Beklova, M.
P08-50
Study of the impact of platinum and palladium on representatives of soil fauna (Folsomia
candida)
Nemcova B., Bednarova I., Mikulaskova H., Beklova M.
P08-51
The effect of green tea extract on a-amanitin induced hepatotoxicity in a murine model
P08-52
The Importance of the Ecotoxicological Assessment for the Risk Management of Cosmetic
Ingredients
Hauaji Zacarias, Cyro; Assanome, Karen; Queiroz, Diana
P08-53
The influence of methionine on the selected biochemical parameters and morphological
picture of the liver of rats intoxicated with sodium fluoride
Stawiarska-Pieta, Barbara; Helis, Agnieszka; Matelska, Sara; Grzegorzak, Natalia; Zalejska-Fiolka,
Jolanta; Birkner, Ewa; Wyszynska, Magdalena
P08-54
The organotin tributyltin and TNF-α induce 17β-hydroxysteroid dehydrogenase type 3
expression
Cornelia Fürstenberger, Roger Engeli and Alex Odermatt
79
Posters
Park, Yong Jin
P08-55
The Regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Tumor
Promotion by Estradiol in Female A/J Mice
Ying-Jan Wang, Rong-Jane Chen, Louis W. Chang, Yuan-Soon Ho, Chih-Hsiung Wu, Pinpin Lin
P08-56
Toxicity and genotoxicity of the air polluted with compounds produced by heavy industry
H. Sezimová, K. Malachová, Z. Rybková
P08-57
Toxicity of microcystin-deficient Planktothrix strains due to chlorine and sulfate containing
aeruginosins
Kohler, Esther; Blom, Judith; Grundler, Verena; Häussinger, Daniel; Kurmayer, Rainer; Gademann, Karl;
Pernthaler, Jakob
P08-58
Toxicological Risk Assessment in Carbon Capture and Storage Technology
Hillebrand, Marcus; Pflugmacher, Stephan; Hahn, Axel
P08-59
Xenoestrogenic and dioxin-like activity in blood of East Greenland polar bears (Ursus maritimus)
Simon E. Erdmann, Rune Dietz, Christian Sonne, Thea Ø. Bechshøft, Katrin Vorkamp, Robert J. Letcher,
Manhai Long, Eva C. Bonefeld-Jørgensen
P09: Food Safety
P09-01
A preliminary assessment of dietary exposure to sulphites in Greek population through
wine consumption
Ioannis N. Tsakiris, Manolis N. Tzatzarakis, Athanasios K. Alegakis, Paraskevi Mitlianga, Kyriakakis Michalis, Polychronis Stivaktakis, Mathaios Kavvalakis, Vlachou Maria, Aristidis M. Tsatsakis
P09-02
Activation of AhR and CYP1A1 induction by pelargonidin in primary human hepatocytes
and human cancer cell lines
Alzbeta Kamenickova, Zdenek Dvorak, Eva Anzenbacherova, Pavel Anzenbacher
P09-03
Activity and Genetic Expression of Antioxidant Enzymes in Liver and Kidney of Rats exposed to a Modified Clay and Its Migration Extract
Jos A, Maisanaba S, Llana Ruíz-Cabello M, Gutiérrez-Praena D, Puerto M, Mate A, Pichardo S, Jordá M,
Aucejo S, Cameán A.
P09-04
Cytotoxicity Study in the Human Cell Line Caco-2 of Dipropyl Sulfide and Dipropyl Disulfide
from Garlic Essential Oil
Jos A, Llana Ruiz-Cabello M, Gutiérrez-Praena D, Pichardo S, Bermúdez JM, Aucejo S, Cameán AM
P09-05
Cytotoxicity, Oxidative Stress and Genotoxicity of Two Novel Modified Clays Intended to
Food Packaging applications in the Human Cell Line HepG2
Jos A, Maisanaba S, Houtman J, Puerto M, Jordá M, Aucejo S, Pichardo, S.
80
P09-06
Histological and Biochemical Study in Rats Subchronically Exposed to an Organomodified
Clay and its Migration Extract
Jos A, Maisanaba S, Puerto M, Gutiérrez-Praena D, Moyano R, Blanco A, Pichardo S, Jordá M, Aucejo S,
Cameán A.
P09-07
Study of the Basal Cytotoxicity and the Oxidative Stress Induction of Carvarcrol, Thymol,
and their Mixture in the Human Cell Line Caco-2
Cameán AM, Llana Ruiz-Cabello M, Gutiérrez-Praena D, Pichardo S, Jos A, Puerto M, Bermúdez JM,
Aucejo S
P09-08
Aflatoxins and Fumonisins Contamination of Home-Made Food (Weanimix) from Cerel-Legume Blends for Children in Ghana
Kumi, Justice; Nicole, Mitchell; A. Asare, George; Dotse, Eunice; Kwaa, Freda; Phillips, Timothy; Ankrah,
Nii-Ayi
P09-09
Are house dust mite or shellfish allergic patients at risk when consuming food containing
mealworm proteins.
Verhoeckx, KCM, van Broekhoven, S., Broekman, HCHP, den Hartog Jager, CF, Gaspari, M, de Jong,
Govardus AH., Wichers, H, van Hoffen, E, Houben, GF, Knulst, AC
P09-10
Cadmium and Lead Levels Consumed by Patients with Oral Hospital Diets Prescriptions
Julia S. Manzoli de Sá; Isabela C Fernandes; Daniele C. F. Moreira; Marcelo A. Morgano; Késia D. Quintaes.
P09-11
Trace elements in tea leaves commercialized in Brazil
Raquel F. Milani; Marcelo A. Morgano; Elisabete S. Saron; Fábio F. Silva; Solange Cadore
P09-12
Determination of Primary Aromatic Amines in Cold Water Extract of Colour Paper Napkin
Samples by Liquid Chromatography-Tandem Mass Spectrometry
P09-13
Evidence for lipid signaling molecules in glycated protein preparations being responsible
for the stimulation of inflammatory signaling in RAGE expressing cells – potential role of
lysophosphatidic acid
Timo Buetler, Hélia Latado, and Gabriele Scholz
P09-14
Hepatotoxic pyrrolizidine alkaloids – Molecular effects on the transcriptome in human
primary hepatocytes
Luckert, Claudia; Hessel, Stefanie; Lenze, Dido; Lampen, Alfonso
P09-15
Induction of micronuclei and cytotoxic effects of ochratoxin A in Vero cells
JG Costa; AS Fernandes; PS Guerreiro; E Filipe, JP Miranda, M Castro and NG Oliveira
P09-16
Influence of the making and cooking pasta on enniatins contents
Font G., Serrano A.B., Tolosa J. and Ferrer E.
81
Posters
Oguzhan Yavuz, Sandro Valzacchi, Eddo Hoekstra and Catherine Simoneau
P09-17
Monitoring Alternaria mycotoxins and pesticide residues in tomato by dispersive liquidliquid microextraction coupled to gas chromatography-tandem mass spectrometry
Font G., Rodríguez-Carrasco, Y., Moltó J.C., Berrada, H.
P09-18
Influence of the Process Conditions on the Formation of 3-MCPD Esters in Palm Oil
Klicia A. Sampaio, Adriana P. Arisseto, Jose V. Ayala, Christian Stevens, Roberta Ceriani, Roland Verhé,
Antonio J.A. Meirelles
P09-19
Liquid Chromatographic determination of histamine in traditionally salted, smoked and
frozen fish with Relation to Microbial Load
M.M. Deabes, S.A. Ahmed, Hayam A. Mansour, Laila A. Mohamed, and Doha A. Salah El din
P09-20
Mutagenicity studies of processed food items and ready-to-eat snacks in Finland
Iyekhoetin
Matthew Omoruyi and Raimo Pohjanvirta
P09-21
Nutritional and toxicological analyses of leaves and fruits of Solanum macrocarpon Linn
(Solanaceae) in Cotonou (Benin)
Dougnon Victorien, Bankolé Honoré, Dougnon Jacques, Klotoé Jean-Robert, Edorh Patrick, Loko
Frédéric, Boko Michel
P09-22
Safety Testing of New Ingredients in Infant Formula using Piglet as an Animal Model
Ali S. Faqi, Adam D. Aulbach and Bjorn A. Thorsrud
P09-23
The scaling of allergenic products for the hazard characterisation of new proteins
Kruizinga, AG; Klein Entink, RH; Blom, WM; Houben, GF; van Bilsen, JHM
P09-24
Toxicological, genotoxicological, antigenotoxicological, cytotoxicity and lifespan studies of
beer and some components
Merinas-Amo, Maria Tania; Villalba-Benito, Leticia; Almagro-Berlanga, Rafael; Romero-Jimenez,
­Magdalena; Mateo-Fernandez, Marcos; Alonso-Moraga, Angeles; Calahorro-Nuñez, Fernando
P09-25
Withdrawal time of Fosfomycin in pigs and broiler chickens after oral and intramuscular
administration
Pérez, Denisa S.; Soraci, Alejandro L.; Tapia, María O.
P11: Immunotoxicology / Immunogenicity
P11-01
Allergic Skin Inflammation Induced by Chemical Sensitizers is Controlled by the Transcription Factor Nrf2.
Zeina El Ali, Cédric Gerbeix, Philippe Esser, Pauline Robert, Jean-Jacques Legrand, Stefan Martin, Marc
Pallardy and Saadia Kerdine-Römer
82
P11-02
An international pre-validation study on the epidermal equivalent sensitizer potency assay
Marc A.T. Teunis, Sander Spiekstra, Mieke Smits, Els Adriaens, Tobias Eltze, Valentina Galbiati, Cyrille Krul,
Robert Landsiedel, Raymond Pieters, Judith Reinders, Erwin Roggen, Emanuela Corsini, Susan Gibbs
P11-03
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Pecaric Petkovic, Tatjana; Gentinetta, Thomas; Dörig, Dario; Buenter, Antonia; Pichler, Werner J.; Hausmann, Oliver
P11-04
Better prediction of immunogenicity of biopharmaceuticals in humans, is it possible?
Dr. Simon Folkertsma, Dr. Babs O. Fabriek, Dr. Geertje van Mierlo, F.J. Tielen, Dr. R. Klein Entink, Dr. E.
Reefman, Dr. C.Krul
P11-05
Brominated flame retardants stimulate immune response in vitro
Eiko Koike, Rie Yanagisawa, and Hirohisa Takano
P11-06
Carbamate pesticides induce apoptosis in human T cells
Li, Qing; Kobayashi, Maiko; Kawada, Tomoyuki
P11-07
Coculture of antigen-presenting cells and keratinocytes: Modulation of compound-related
increase of CYP mRNA in antigen-presenting cells
Hennen J., Cohrs C., John A., Seidel A., Blömeke B.
P11-08
Development of skin sensitization test method utilizing THP-1 cells cultured on a collagen
vitrigel membrane chamber
Uchino, Tadashi; Shimizu, Kumiko; Yamashita, Kunihiko; Kojima, Hajime; Takezawa, Toshiaki; Akiyama,
Takumi; Ikarashi, Yoshiaki
P11-09
Differential Effect of Cyanobacterium Anabaena sp. Lipopolysaccharide (LPS) on Rat Brain Microglia-derived Proinflammatory and Anti-inflammatory Cytokine and Chemokine generation
David Macadam, Mary L. Hall, Domonkos Feher, Philip Williams, and Alejandro M.S. Mayer
Posters
P11-10
Effect of LPS on CD40 Expression on Spleen Cells of male BALB/C Mice – A Potential
­Model for the Investigation of Immunosupressant Compounds
Philip Allingham, Silke Huber, Anne-Laure Leoni, Wolfram Riedel
P11-11
Identification and statistical power of mRNA based classifiers for direct immunotoxicity
Shao, Jia; Peijnenburg, Ad C. C. M.; Hendriksen, Peter J. M.; van Loveren, Henk; Volger, Oscar L.
P11-12
Methlychloroisothiazolinone/methylisothiazolinone: a contact sensitizer or a respiratory
allergen?
Dearman, Rebecca; Hayes, Mark; Kimber, Ian
P11-13
The aryl hydrocarbon receptor: differential contribution to type 17 T cell subsets
Dearman, Rebecca; Hayes, Mark; Ovcinnikovs, Vitaly; Kimber, Ian
83
P11-14
Method-Validation and Assessment of Immunotoxicity Potential for New Drugs
Sagelsdorff, Peter; Canut, Lourdes; Dickel, Denise; Fernandez, Elena; Mendoza, Paula; Reig, Vanessa
P11-15
Perinatal exposure to an insecticide methamidophos affected the immune response to
virus infection in the next generation of mice
Watanabe, Wataru; Yoshida, Hiroki; Hirose, Akihiko; Kurokawa, Masahiko
P11-16
Protein kinase CK2 and JNK control Nrf2 activation in response to skin contact sensitizers
in THP1 cells.
Marie de Bourayne, Zeina El Ali, Odile Filhol, Claude Cochet, Marc Pallardy, Saadia Kerdine-Römer
Concert Hall
P04: Clinical Toxicology
P04-01
“Synthe-tic co-caine” as legal cocaine hides synthetic cannabinoids
CA Locatelli, D Lonati, E. Buscaglia, S Vecchio, A Giampreti, VM Petrolini, F. Chiara, M Aloise, E Cortini,
P Papa, L Rolandi, L Rocchi, C Rimondo, C Seri, G Serpelloni
P04-02
Italian viper venom neurotoxicity: clinical evidences in 11-year experience of Pavia poison
control centre
CA Locatelli, D Lonati, A Giampreti, VM Petrolini, S Vecchio, M Aloise, F Chiara, D Flachi, L Manzo
P04-03
Antidotes supply in emergency from Pavia Poison Control Centre
Carlo Alessandro Locatelli, Eleonora Buscaglia, Marta Mazzoleni, Davide Lonati, Andrea Giampreti,
Sarah Vecchio, Valeria Margherita Petrolini, Anna Losurdo
P04-04
Chloracne /MADISH-like cystic lesions induced by Vemurafenib:
A model for the tissue modelling effects of dioxin in humans
Gürkan Kaya, Nikolina Saxer-Sekulic, Olivier Sorg, Luc Thomas, Jean-Hilaire Saurat
P04-05
Co-Cr wear products derived from metal-on-metal articulations induce apoptosis on
monocyte-like U937 cells
Posada, Estefan; Olga, Maria; Grant, Helen; Tate, Rothwelle J
P04-06
Effects of MDMA and methylphenidate on steroid levels in healthy humans
Julia Seibert, Cédric M. Hysek, Matthias E. Liechti and Alex Odermatt
P04-07
Is Excessive Acetaminophen Intake Associated with Transaminitis in Patients with Dengue
Fever?
D. Pandejpong, P. Saengsuri, R. Rattarittamrong, C. Chouriyagune
P04-08
Protective effects of para-aminosalicylic acid (PAS) against manganese (Mn)-induced
neurotoxicity
Marreilha dos Santos AP, Andrade Vanda, Santos Dinamene, Lucas Rui, Aschner Michael, Batoréu M Camila
84
P04-09
Recent Epidemiologic Features of Carbon Monoxide Poisoning in South Korea: A Single
Center Retrospective Cohort Study
Choi, Byungho; Jeon, Jin; Ryoo, SeungMok; Seo, Dongwoo; Kim, Wongyoung; Oh, Bumjin; Lim, Kyoungsoo; Sohn, Changhwan
P04-10
Role of Skeletal Muscle Transport Systems in Statin-Induced Myotoxicity
Feuerstacke, Christian; Stieger, Bruno
P04-11
The effect of antioxidants on the morphological picture of thymus and heart of rats
intoxicated with sodium fluoride
Barbara Stawiarska-Pięta, Natalia Grzegorzak, Katarzyna Kuczera, Agnieszka Helis, Jolanta ZalejskaFiolka, Beata Bielec, Ewa Birkner, Robert Kubina
P04-12
The levels of the antioxidant enzymes and trace elements in patients with chronic viral
hepatitis and alcoholic liver disease
Ahmet Sayal, Nuri Erçin, Ahmet Erdil, Yasemin Kartal, Zeliha Kayaaltı.
P04-13
The Toxicological Examination of the Victims in a Chilean Prison Fire
Bastías Chian, María José; Cortes Picazo, Patricio; Herrada H., Luis; Hananias, Karime
P04-14
Unexpected Combined Drug Intoxication (CDI). A case report.
Ángel Luis Pérez Martínez, Francisco Javier González Delgado, Carmen Rubio Armendáriz, Inmaculada
Frías Tejera, Luis Manuel Menéndez Quintanal, Francisco Javier Hernández Díaz, Arturo Hardisson de
la Torre
P10: Genotoxicity
P10-01
Antigenotoxic Effects of Ferulic Acid on Sepsis-Induced DNA Damage in the Liver and
Kidney of Wistar Albino Rats
M Bacanlı, S Aydın, G Taner, T Şahin, AA Başaran and N Başaran
Posters
P10-02
Biological activities of medicinal plants and some phenolic components: toxicity, DNA
protecting effects and tumour grow inhibition
Merinas-Amo, Maria Tania; Almagro-Berlanga, Rafael; Mateo-Fernandez, Marcos; Calahorro-Nuñez,
Fernando; Alonso-Moraga, Angeles; Romero-Jimenez, Magdalena
P10-03
Current Status of the Cosmetics Europe Animal-Free Genotoxicity Projects
Reisinger K, Pfuhler S, Fautz R, Quedraogo G, Latil A, Kenny J, Moore C, Kühnl J, Hewitt NJ, Barroso J
P10-04
The Hen’s Egg Test for Micronucleus-Induction (HET-MN): Results of the Method Transfer
prior a Validation Study
Reisinger K., Fieblinger D., Heppenheimer A., Kreutz J., Luch A., Maul K., Pirow R., Poth A., Strauch P.,
Wolf T.
85
P10-05
Cytotoxic and genotoxic assessment of Euterpe oleracea fruit oil and Pentaclethra
macroloba oil in human peripheral lymphocytes
E.L. Maistro, E.S. Marques, M.S.F. Tsuboy
P10-06
Determination of Lymphocyte DNA Damage using The Comet Assay in Sandbalsting
Workers Exposed to Crystalline Silica Dust
Esma Söylemez, Zeliha Kayaaltı, Dilek (Kaya) Akyüzlü, Tülin Söylemezoğlu
P10-07
Evaluation of Genotoxic Effect of Arsenic in Silver Mining Plate Workers using Alkaline
Comet Assay
Esma Söylemez, Zeliha Kayaaltı, Dilek (Kaya) Akyüzlü, Engin Tutkun, Tülin Söylemezoğlu
P10-08
The 4977 bp and 7436 bp Mitochondrial DNA Deletions in Workers with Acute Exposed to
Iridium-192
Esma Söylemez, Zeliha Kayaaltı, Dilek (Kaya) Akyüzlü, Engin Tutkun, Tülin Söylemezoğlu
P10-09
Effects of Reduction of the Top Concentration Limit Used in the In Vitro Chromosomal
Aberration Test
Morita, Takeshi; Hatano, Akiko; Honma, Masamitsu
P10-10
Evaluation of Aromatic Amines in the EpiDermTM 3D Human Reconstructed Skin
Micronucleus (RSMN) Assay
Holland, Daniela; Barnett, Brenda; Aardema, Marilyn; Pfuhler, Stefan
P10-11
Evaluation of In Vivo DNA Damaging and Oxidative Stress Effects of Sertraline
Ayca Aktas, Dilek Battal, Mehmet Ali Sungur, Serap Yalin, Ela Kadıoglu, Ebru Derici Eker, Nefise Ozlen
Sahin, Sahan Saygi
P10-12
Exposure-response relationships in adolescents of the 2nd Flemish Environment and
Health Study: The correlation between polycyclic aromatic hydrocarbons (PAHs) and
DNA damage
Eva Govarts, Carmen Franken, Gudrun Koppen, Elly Den Hond, Greet Schoeters,
P10-13
Genotoxic assessment of tobacco-specific nitrosamine mixtures using the in vitro γH2AX
assay
Carolina Garcia-Canton, Graham Errington, Clive Meredith
P10-15
Modulating Effects of Pycnogenol on Sepsis Induced DNA Damage In the Liver and Renal
Tissue Cells of Rats
Gökçe Taner, Sevtap Aydın, Merve Bacanlı, Tolga Şahin, A. Ahmet Başaran, Nurşen Başaran
P10-16
Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic
effects of vanillic acid
Gökçe Taner, Deniz Özkan Vardar, Sevtap Aydın, Zeki Aytaç, Ahmet Başaran, Nurşen Başaran
86
P10-17
New Study Design Considerations for Somatic and Germ Cell Analysis in the Big Blue®
Transgenic Rodent Mutation Assay
Robert R. Young, David Bruning, Marilyn J. Aardema
P10-18
Noncanonical activation of ATR-p53 axis by DNA-protein crosslinks controls cell death
responses to formaldehyde
Anatoly Zhitkovich, Victor Wong, Jessica Morse
P10-19
Preclinical safety assessment of aqueous Gentiana lutea radix extracts
Turek, Claudia; Mörbt, Nora; Felenda, Jennifer; Link, Kerstin; Christiane, Beckmann; Müller, Margit;
Vögele, Peter; Stintzing, Florian
P10-20
Predicting in vivo genotoxicity using mRNA and miRNA data from two in vitro liver models.
Linda Rieswijk, Daneida Lizarraga, Karen Brauers, Stan Gaj, Jos C. Kleinjans, and Joost H.M. van Delft
P10-21
Retrospective study of false positive results in in vitro genotoxicity studies
Hofman-Hüther, Hana
P10-22
Selected methyleugenol metabolites suppress topoisomerase I activity and diminish the
DNA-damaging properties of the DNA-topoisomerase poison camptothecin in human
colon carcinoma cells
Groh, Isabel Anna Maria; Schröter, Anika; Marko, Doris; Esselen, Melanie
P10-23
The food dye Quinoline Yellow modulated mRNA transcriptional profile associated to DNA
damage signaling pathway
Farah Maria Drumond Chequer; Vinícius de Paula Venâncio, Maria Lourdes Pires Bianchi, Lusânia
Maria Greggi Antunes
P10-24
The ToxTracker assay: Unveiling the carcinogenic properties of chemicals.
P15: Methods in Toxicology
P15-01
3-month intravenous bolus injections via the femoral vein and an external access port in rats
Perron, Josee; Armer, Lynn; Tavcar, Robert; Forster, Roy
P15-02
A 4D lung multi-culture system which mimicking alveolar cellular organization to study the
toxic potential of airborne particles
T. Serchi, S.G. Klein, A. Jehanno, S. Legay, S. Contal, J. Hennen, A.C. Gutleb, L. Hoffmann and B. Blömeke
P15-03
A new culture system activating hepatic function of HepG2 cells utilizing a collagen vitrigel
membrane chamber and its application to liver metabolism and toxicity assays
Oshikata-Miyazaki Miyazaki, Ayumi; Ishida, Seiichi; Kuroda, Yukie; Takezawa, Toshiaki
87
Posters
Giel Hendriks, Fabienne Calléja, Bruno Morolli, Bob van de Water and Harry Vrieling.
P15-04
A novel approach for extrapolating toxicity in vivo by analyzing the behavior of stem cells
cultured on TOSHI (tissue/organ sections for histopathology)-substrata derived from experimental animals after exposing chemicals
Takezawa, Toshiaki
P15-05
A refined surgical technique for telemetry in group housed macaques (M. fascicularis)
J. Luft, J. Sternberg, M. Fine; D. Sarazan
P15-06
Assessment of benzene-induced hematotoxicity using a human-like hematopoietic lineage
in NOD/Shi-scid-IL2Rγnull mice
Masayuki Takahashi, Noriyuki Tsujimura, Tomoko Yoshino, Masahito Hosokawa, Tadashi Matunaga,
Satoshi Nakasono
P15-07
Bovine Corneal Opacity and Permeability Test (BCOP) – an Appropriate in vitro Alternative
Method for Evaluation of the Potential Ocular Corrosivity or Severe Irritancy of Nonpolar
Substances?
Weidmann, Katharina; Schmid, Sandra; Albrecht, Achim; Schleh, Carsten; Allingham, Philip; Leoni,
Anne-Laure
P15-08
Construction of a mouse MA-10 Leydig cell line stably expressing a HSDB luciferase
reporter
Roger Engeli, Cornelia Fürstenberger and Alex Odermatt
P15-09
Development and validation of a gas chromatography/mass spectrometry method for
simultaneous quantification of benzylpiperazine and its metabolites: application to a pilot
toxicokinetic study in mice
M. Monteiro, M. Carvalho, M.L. Bastos and P. Guedes de Pinho
P15-10
Development of a Simple and Rapid Spectrophotometric Method for the Quantification
of Carboxyhemoglobin
Ana Oliveira, Fernanda Sampaio-Silva, Félix Carvalho, Ricardo Silvestre, Ricardo Jorge Dinis-Oliveira
P15-11
Identification of psychoactive substances in “legal highs” marketed in Portugal
Ana Margarida Araújo, Maria de Lourdes Bastos, Márcia Carvalho, Félix Carvalho, Helena Gaspar,
Ana Cardoso Matias, Paula Guedes de Pinho
P15-12
Dose Determination of Particles for Air/Liquid Interface (ALI) Technique for Toxicity Testing on Human Lung Cells
Troeller S. and Linsel G.
P15-13
Extraction of Perfluorinated Alkyl Acids and Lipophilic Persistent Organic Pollutants from
Human Serum
C. Bjerregaard-Olesen, R. Bossi, E.C. Bonefeld-Jørgensen
P15-14
Flow-through versus static design for dermal absorption experiments in vitro
K. Guth, M. Schäfer-Korting, E. Fabian, E. Haltner-Ukomadu, B. van Ravenzwaay, R. Landsiedel
88
P15-15
Following the Fate of Modified Microcystin-LR
Grundler, Verena; Kohler, Esther; Faltermann, Susanne; Blom, Judith; Pernthaler, Jakob; Fent, Karl;
Gademann, Karl
P15-16
Historical Control Data generated in a 2-Year Life Span Study in Wistar Rats (Crl:Wi(Han))
demonstrate a Reliable Model for Carcinogenicity Studies
Philip Allingham, Anne-Laure Leoni, Achim Albrecht, Wolfram Riedel, Susan Gähler, Gabriele Pohlmeyer-Esch, Klaus Weber
P15-17
Implementation and establishment of blood toxicity protocol for use of pre-clinical testing
of drugs. Studies in rats.
Teles, Alessandra; Gorniak, Silvana
P15-18
Local tolerance evaluation of fibrin and thrombin solution in a free-flap model in the
juvenile Sprague-Dawley rat
Colombo P, Neri MT, Carù F, Scarpellini M, Bacci M, Guarnieri C, Ali Youssef D, Riccardi E, Rosa B
P15-19
Novel formats for the comet assay
Sergey Shaposhnikov, Gunnar Brunborg, Amaya Azqueta, Isabel Gaivão, Andrew Smart, Andrew R. Collins
P15-20
Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model
is highly correlated with results from in vitro tests
Myoung joo, Park; Dae-Seop, Shin; Sung- Hoon, Ahn; Myung Ae, Bae
P15-21
Predicting intramuscular discomfort with the Slug Mucosal Irritation assay
Adriaens, Els; Lenoir, Joke; Remon, Jean Paul
P15-22
Read-across approach for hazard assessment of fatty acid esters via investigating the
lipase mediated hydrolysis
P15-23
Searching of Standard Comet Assay Parameters for Detecting Lymphocyte DNA Damage
Using Fourteen Different Test Conditions
Esma Söylemez, Zeliha Kayaaltı, Tülin Söylemezoğlu
P15-24
SLIM: a smart way from innovations to humans
Marc Teunis, Rob Vandebriel, Ruud Woutersen, Diane Kegler, Jan Raaijmakers, Jan van der Valk,
Raymond Pieters, Cyrille Krul
P15-25
Substantive reduction of animal numbers on regulatory toxicology studies by using microsampling or sample-sparing techniques
Lawrence R, Mitchell D, Coleman D
P15-26
Successful continuous intravenous infusion in post-weaning juvenile rats
Allais, Linda; Gerhardy, Cécilia; Briffaux, Jean-Paul; Vignand, Philippe; David, Sylvie; Fant, Pierluigi
89
Posters
Li, Qiang; Lee, Moung Sook; Jost, Martina; Höppner, Christoph; Kreiling, Reinhard
P15-27
The evaluation of the embryotoxic chemicals by using undifferentiated human embryonic
stem cells
Eui-Man Jung, Yeoul Choi, Hong-Seok Kang and Eui-Bae Jeung
P15-28
The role of the transcutaneous electrical resistance test (TER) in the sequential testing
strategy aimed at evaluating dermal irritating and corrosive properties of chemical substances
Gruszka, Katarzyna; Mrzyk, Inga; Sornat, Robert; Kropidlo, Aneta; Drzewiecka, Agnieszka
P15-29
The Threshold of Toxicological Concern as a Tool For The Safety Assessment of Cosmetic
Ingredients
Assanome, Karen; Queiroz, Diana; Zacarias, Cyro
P15-30
Development of MISPE-MS/MS method for Cocaine and its metabolites in vitreous humor
Raquel M. T. Fernandes, Júlio César Santos Júnior, Carla Giane Loss, Nelci Fenalti Höehr, Pedro Carlos
Mollo Filho, Ruggero Bernardo Felice Guidugli and Marcos N. Eberlin
P16: Omics
P16-01
A proteomic approach to investigate the modification in the proteome of the cytoplasmatic
compartment of Balb/3T3 cells after exposure to gold nanoparticles (AuNPs)
Hubert Chassaigne, Sabrina Gioria, Donatella Carpi, Antonietta Parracino, Paola Barboro and François
Rossi
P16-02
Untargeted metabolomics in human health risk assessment of nanoparticles: data processing workflow challenges
Hubert Chassaigne, Sabrina Gioria, Giorgio Tomasi, Agnieszka Kinsner-Ovaskainen, François Rossi,
Claude Guillou
P16-03
Amiodarone: a metabolomic approach of different modes of action (MOAs) in rats
G. Montoya, V. Strauss, E. Fabian, H. Kamp, W. Mellert, T. Walk, R. Looser, M. Herold, G. Krennrich, E.
Peter and B. van Ravenzwaay
P16-04
Mechanistic explanation of different metabolomics patterns in rat plasma for the differentiation of direct thyroid hormone synthesis inhibitors and compounds increasing thyroid
hormone clearance
G. Montoya, V. Strauss, E. Fabian, H. Kamp, W. Mellert, T. Walk, R. Looser, M. Herold, G. Krennrich, E.
Peter and B. van Ravenzwaay
P16-05
Application of metabolomics in vitro for identification of toxicological modes of action
Tzutzuy Ramirez, Natalie Bordag, Werner Mellert, Hennicke Kamp, Tilmann Walk, Ralf Looser and
Bennard van Ravenzwaay
P16-06
Changes in Hepatic Gene Expression Induced by Various Statin Formulations in Chimeric
PXB-Mouse® with Highly Humanized Liver
Mikiro Nakashima, Hidehisa Tachiki, Hatsun e Enomoto, Takashi Shimada and Shin-Ichiro Nagatsuka
90
P16-07
Characterisation of novel Australian snake venom toxins as potential therapeutic agents.
Liam St Pierre, Paul Masci, Kong-Nan Zhao, John De Jersey and Martin Lavin.
P16-08
Genetic Variations of DMT1 Gene and Blood Iron, Lead and Cadmium Levels in Thalassemia
Patients
Tülin Söylemezoğlu, Zeliha Kayaalti, Derya Söylemez Gökyer
P16-09
Human skin proteome: insights into chemical induced skin sensitisation
Zhu, Zheying; Fang, Min
P16-10
Oxidative stress in carcinogenesis: a Toxicogenomics based comparison between liver and
colon carcinoma cells.
Deferme L, Briedé JJ, Cavill R, Kleinjans JCS
P16-11
Percellome Toxicogenomics application to Sick House Syndrome-level Inhalation Toxicity
with Special Reference to Transcriptomic Response of Hippocampus.
Jun Kanno, Ken-ichi Aisaki, Katsuhide Igarashi, Yuhji Taquahashi and Satoshi Kitajima
P16-12
Proteomic investigations into mechanisms of nephrotoxicity induced by 3-MCPD and its
dipalmitate in rat kidney
S. Sawada, C. Meckert, J. Potkura, A. Oberemm, A. Lampen
P16-13
Systems biology approach reveals a dose-dependent recovery of primary human airway
epithelium culture after exposure to cigarette smoke
Carole Mathis, Stephan Gebel, Carine Poussin, Arnd Hengstermann, Dirk Weisensee, Alain Sewer,
Vincenzo Belcastro, Sam Ansari, Sandra Wagner, Julia Hoeng, Manuel C. Peitsch
P16-14
XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms in chronic obstructive pulmonary
disease
Posters
Ayşegül Bacaksiz, Zeliha Kayaalti, Dilek (Kaya) Akyüzlü, Esma Söylemez, Gülseren Karabıyıkoğlu, Hatice
Taslak, Tülin Söylemezoğlu
P17: Pesticide Toxicology
P17-01
Analysis of hepatotoxic mixture effects of (tri)azole fungicides in a broad dose range
Heise, T., Rieke, S., Schmidt, F., Ladwig, M., Haider, W., Kneuer, C., Pfeil, R., Niemann, L., Marx-Stoelting, P.
P17-02
Analysis of toxic heavy metals and pesticides in Mucuna pruriens by Spectroscopic
methods
Siddique NA, Mujeeb M, Ahmad S, Aamir M, Rshid M
P17-03
Combination effects of (tri)azole fungicides on the adrenal gland in vivo
Rieke S., Schmidt F., Heise T., Pfeil R., Ladwig, M., Haider, W., Hirsch-Ernst, KI., Niemann L., MarxStoelting, P.
91
P17-04
Concentration Addition Model to Assess Activation of the Pregnane X Receptor (PXR) by
Pesticide Mixtures Found in the French Diet
G. de Sousa, A. Nawaz, R. Rahmani
P17-05
Currently used pesticides and their mixtures affect the function of sex hormone receptors
and aromatase enzyme activity
Lisbeth Stigaard Kjeldsen, Mandana Ghisari and Eva Cecilie Bonefeld-Jørgensen
P17-06
Establishment of cohort study for Agricultural worker exposured pesticides in KOREA
Mihye Jeong, Soon-Sung Hong, Kyung-Hun Park, Soo Jin Lee
P17-07
Evaluation of DNA damage and telomerase activity in liver and kidney after long term rabbits exposure to chlorpyrifos.
Vasilaki Fotini, Maravgakis Georgios, Stivaktakis Polychronis, Tsitsimpikou Christina, Vakonaki Elena,
Fragkiadaki Persefoni, Kovatsi Leda, Christakis-Hampsas Maria, Emmanuel N. Kokkinakis, Tsatsakis M.
Aristidis
P17-08
Evaluation of organochlorine pesticides- mediated toxicity in vitro and ameliorating effect
of n-acetylcystein and curcumin
Manushi Siddarth, Sudip K Datta, Rafat S Ahmed, Om P Kalra, Basu D Banerjee and Ashok K Tripathi
P17-09
In vitro – in vivo correlations for endocrine activity of a mixture of 5 currently used pesticides
Camilla Taxvig, Niels Hadrup, Julie Boberg, Marta Axelstad, Rossana Bossi, Eva Cecilie Bonefeld Jørgensen & Anne Marie Vinggaard
P17-10
Mechanism of action of the herbicide Paraquat mediated oxidative stress on erythroid differentiation pathway in bone marrow and spleen of mice
Bhardwaj, Nitin; Saxena, Rajiv K
P17-11
New biochemical and physiological aspects of chlorpyrifos neurotoxicity
Rosalovsky, Volodymyr; Salyha, Yuriy
P17-12
Organophosphates used in agriculture and produce export
Aikaterini N. Kokkinaki, Emmanuel N. Kokkinakis, Tzatzarakis Manolis, Fragkiadaki Persefoni, Tsakiris
N. Ioannis, Vynias Dionisios, Georgios Maravgakis, Matthaios Kavvalakis, Aristidis M. Tsatsakis
P17-13
Pesticide training as a major factor sustaining public health, during farming of certified
produce.
Aikaterini N. Kokkinaki, Emmanuel N. Kokkinakis, Georgia Tavladaki, Georgia Panagiotaki, Sofia Niniraki,
Giannakoudakis Konstantinos, Tsakiris Ioannis, Kavvalakis P. Mathaios, Aristidis M. Tsatsakis
P17-14
Potential ecotoxicity impact induced by plant protection products in Finnish crop farming
K. Räsänen, T. Mattila, P. Porvari, S. Kurppa
P17-15
The effect of glyphosate on the spontaneous motoric activity of rat isolated jejunum strips
Mendel, Marta; Chlopecka, Magdalena; Dziekan, Natalia; Karlik, Wojciech
92
P17-16
The role of microtubule on dithiocarbamate cytotoxicity
Eugene Gonzalez-Lopez and Shu-Yuan Cheng
P17-17
Toxic effects of combined (tri)azole fungicides on prostate gland and testis in rats
Schmidt F, Rieke S, Heise T, Ladwig M, Haider W, Hirsch-Ernst KI, Niemann L, Pfeil R, Marx-Stoelting P
P17-18
Understanding the imidacloprid metabolism in long-term exposure through a comparative
study of imidacloprid and its major metabolite levels in the urine and hair of intentionally
exposed rabbits
Mathaios P. Kavvalakis, Manolis N. Tzatzarakis, Stivaktakis Polychronis, Manolis Barbounis, Marina
Goumenou, Athanasios Alegakis, Elisavet Renieri, Dionisis Vynias, Aristidis M. Tsatsakis
Club Casino
P05: Computational Toxicology
P05-01
A new approach based on QSAR based expert system and a quantitative read across
methodology to achieve better in silico genotoxicity assessment of drugs, impurities
and metabolites
Suman Chakravarti, Roustem Saiakhov
P05-02
A quantitative weight-of-evidence approach used in decision support for safety and risk
assessment
J.F. Rathmana, C. Yang, S. Boyerc, C. Hasselgrenc, H. Zhoua
P05-03
Assessing the inter-individual variability of toxicokinetic processes of trichloroethylene
(TCE) in humans
Olie J.D.N., Boerleider R.Z., DeVries I., Meulenbelt J., Hunault C.C.
Cronin, Mark; Enoch, Steven; Madden, Judith; Richarz, Andrea; Roberts, David
P05-05
Data mining toxicity effects through an ontology approach to investigate toxicity mode of
action
Vessela Vitcheva, Chihae Yang, Aleksandra Mostrag-Szychtying, Mark Nelms, Petko Alov, Steve Enoch,
Ivanka Tsakovka, James Rathman, Mark Cronin
P05-06
Development of New COSMOS oRepeatDose and non-cancer Threshold of Toxicological
Concern (TTC) Databases to Support Alternative Testing Methods for Cosmetics Related
Chemicals
Chihae Yang, Massimo Ambrosio, Kirk Arvidson, Sue Barlow, Alan Boobis, Maria Checheva, Mark
Cronin, Susan Felter, Elena Fioravanzo, Heli Hollnagel, Dimitar Hristozov, Kristi Jacobs, Detlef Keller,
Aleksandra Mostrag-Szylchtying, Mark Nelms, James Rathman, Andrea Richarz, Ivanka Tsakovska,
Stephane Vidry, Vessela Vitcheva, Andrew Worth
93
Posters
P05-04
Category Formation and Read-Across for Toxicity Prediction: A Review of the Current
Status and Future Directions
P05-07
Development of Integrated In Silico Models for Toxicity Prediction Focussing on Cosmetic
Ingredients
Richarz, Andrea-Nicole; Neagu, Daniel; Yang, Chihae; Fioravanzo, Elena; Péry, Alexandre; Worth,
Andrew; Berthold, Michael; Cronin, Mark
P05-8
In Silico Workflows for Toxicity Prediction Implemented into KNIME
Richarz, Andrea-Nicole; Enoch, Steven; Hewitt, Mark; Madden, Judith; Nelms, Mark; Przybylak,
Katarzyna; Yang, Chihae; Berthold, Michael; Meinl, Thorsten; Ohl, Peter; Cronin, Mark
P05-09
Development of the KY-methods for used in toxicity prediction
Yuta, Kohtaro
P05-10
External Validation of the Toxicological Categories in Hazard Evaluation Support System
Integrated Platform (HESS)
Sakuratani, Yuki; Yamada, Takashi; Ikenaga, Yutaka; Yamada, Jun; Ohta, Satoshi; Hayashi, Makoto
P05-11
Generalized workflow for generating high quality in-silico models for off-target mediated
toxicity
Anger, Lennart T.; Schleifer, Klaus-Juergen; Schrenk, Dieter; Rohrer, Sebastian
P05-12
Human Bioaccumulation Potential Simulated in R and Implemented into KNIME interface
Alicia Paini, José Vicente Sala Benito, Monika Gajewska, Andrew Worth, José Manuel Zaldivar Comenges
P05-13
Modelling Chemically-Induced Cell Toxicity: an Open Source Implementation of a Virtual
Cell Based Assay Model
Alicia Paini, José Vicente Sala Benito, Milena Mennecozzi, Monika Gajewska, Andrew Worth,
José Manuel Zaldivar Comenges
P05-14
Identification of potential CMR substances under REACH by (Q)SAR
Eva B. Wedebye, Nikolai G. Nikolov, Marianne Dybdahl, Sine A. Rosenberg, Jay R. Niemelä
P05-15
Integration of Omics Data and Systems Biology Modeling: Response of the NFE2L2
Pathway in Human Renal Kidneys Cells exposed to Cyclosporine A in vitro
Jérémy Hamon, Paul Jennings, Frédéric Y. Bois
P05-16
Molecular Modelling of LXR Binding to Evaluate the Potential for Liver Steatosis
E. Fioravanzo, A. Bassan, M.T.D. Cronin, S. Kovarich, C. Manelfi, A.-N. Richarz, I. Tsakovska, A.P. Worth.
P05-17
Multi-scale modeling for individualized spatiotemporal prediction of drug effects
Juan G. Diaz Ochoa, Joachim Bucher, Jens Niklas, Klaus Mauch
P05-18
New strategies to develop chemical categories in the context of REACH – work in progress
Batke M, Bitsch A, Gundert-Remy U, Guetlein M, Helma Ch, Kramer S, Maunz A, Partosch F, Seeland M,
Stahlmann R
94
P05-19
Pharmacophore-based virtual screening as a prioritization tool to assess mechanism-based
cardiotoxic effects of small organic molecules
Daniela Schuster, Michael Edtbauer, Jadel M. Kratz, Christina E. Mair, Steffen Hering,
Judith M. Rollinger
P05-20
Pharmacophore-based virtual screening in the search for endocrine disrupting
chemicals – successful case studies
Anna Vuorinen, Alex Odermatt, Daniela Schuster
P05-21
Skin sensitization study by a new qualitative sttructure-toxicity relationships (QSTR)
approach: K-step Yard Sampling (KY) methods.
Sato, Kazuhiro; Kusaka, Yukinori; Yuta, Kohtaro
P05-22
The Danish (Q)SAR Database Update Project
Nikolai G. Nikolov, Marianne Dybdahl, Sine A. Rosenberg, Eva B. Wedebye
P05-23
Toward better understanding of liver steatosis MoA: Molecular modelling study of PPAR
gamma receptor
Al Sharif, Merilin; Alov, Petko; Cronin, Mark; Fioravanzo, Elena; Tsakovska, Ivanka; Vitcheva, Vessela;
Worth, Andrew; Yang, Chihae; Pajeva, Ilza
Tuesday, September 3rd, 2013
Posters
Location:
Auditorium Foyer:P12/01 – P14/28, P20/01 – P21/03
Concert Hall:
P18/01 – P18/27, P23/01 – P25/28
Club Casino:
P19/01 – P19/18; P22/01 – P22/05
Auditorium Foyer
P12: In vitro Toxicology
P12-01
A human 3D myocardial microtissue model for cardiotoxicity testing
Philippe Beauchamp, Irina Agarkova, Wolfgang Moritz, Jens Kelm, Christian Zuppinger
P12-02
A physiologically relevant HepG2 cell based 3D cell culture model for high throughput
toxicity studies
Price, Leo; van de Water, Bob; van Delft, Joost; Commandeur, Jan; Braver, Michiel; Coonen, Maarten;
Ramaiahgari, Sreenivasa; Jennen, Danyel; Meerman, John
95
P12-03
A Triple cell co-culture model of the air-blood barrier reconstructed from primary human cells
Jackson, George; Mankus, Courtney; Oldach, Jonathan; Child, Matthew; Spratt, Maureen; Kandarova,
Helena; Ayehunie, Seyoum; Hayden, Patrick
P12-04
Air/Liquid Interface (ALI) technique for toxicity testing of gaseous compounds on human
lung cells
Troeller S., Linsel G., Huettig N., Bauer M., Graebsch C., Smirnova L., Pirow R., Liebsch M., Berger-Preiß
E., Kock, H., Oertel A., Ritter D., Knebel, J.
P12-05
Alternative in-vitro phototoxicity test using reconstructed skin model, KeraSkin®
Yang-Hwan Ryu, Su-Hyon Lee
P12-06
Development of a new reconstituted human cornea model to assess the eye irritation
Su-Hyon Lee, Haeng-Sun Jung, Kyoung-Mi Jung, Kyoung-Min Lim
P12-07
Evaluating the micronucleus induction potential for the genotoxicity assay using the
­KeraSkin® human skin model
Su-Hyon Lee, Haeng-Sun Jung
P12-08
Amphotericin B: relationship between nephrotoxicity and inhibition of PKA and p38 MAPK
signaling pathways
França, F.D., Tagliati, C.A., Chaves, M.M.
P12-09
An automated system for a stable and reproducible long-term cultivation of epithelial cells
at the air-liquid interface – the CULTEX®LTC module
Michaela Aufderheide, Jessica Rach, Niklas Möhle
P12-10
An in vitro model of the renal proximal tubule composed of small intestinal submucosa
(SIS) and human kidney-derived cells (hKDCs)
Hoppensack, Anke; Schanz, Johanna; Kazanecki, Christian; Colter, David; Walles, Heike
P12-11
An investigation into the toxicity and genotoxicity of brominated flame retardants in
SHSY-5Y cells
Sostare, Jelena; Michelangeli, Francesco; Hodges, Nikolas
P12-12
Analysis of the Validated Epiderm Skin Corrosion Test (EpiDerm SCT) and a Prediction
Model for Sub-Categorization According to the UN GHS and EU CLP.
Helena Kandarova, Silvia Letasiova, Tatiana Milasova and Mitchell Klausner
P12-13
Arctigenin’s mode of toxicity in oxidative metabolizing cell lines.
Virginie Riebel, Brecht K, Bonifacio A, Marcellin M, Couttet, P, Chibout SD, Pognan F, Wolf A, and
Uteng M.
P12-14
Are in vitro methods really useful for eye irritation assessment of children products?
Fragoso Rocha, Bianca; Queiroz, Diana; Fonseca, Vitor; Lucena, Kaline; Sá-Rocha, Vanessa
96
P12-15
Are structural analogues to bisphenol A a safe alternative?
Rosenmai, Anna; Dybdahl, Marianne; Pedersen, Gitte Alsing; Pedersen, Mikael; van Vugt-Lussenburg,
Barbara; Taxvig, Camilla; Vinggard, Anne Marie
P12-16
Bioengineered carbon-encapsulated magnetic nanoparticles as target antibody delivery
systems in glioma toxicity
Monika A. Cywinska, Ireneusz P. Grudzinski, Anita Kosmider, Magdalena Poplawska, Michal
­Bystrzejewski, Andrzej Cieszanowski, Agnieszka Ostrowska
P12-17
Cell cycle-related genes transcriptionally induced by the mycotoxin Zearalenone
Vaccari, Monica; Perdichizzi, Stefania; Mascolo, Maria Grazia; Silingardi, Paola; Morandi, Elena;
­Rotondo, Francesca; Guerrini, Angela; Bergamini, Cecila; Colacci, Annamaria
P12-18
Comparison of in silico and two in vitro high content screening approaches, phospholipidosis and lysosomal trapping, in predicting in vivo phopholipidosis
Frost, Kerry; Bauch, Caroline; Ellis, Samantha; Woodhouse, Heather; Walker, Paul
P12-19
Cytotoxicity of Pycnogenol and Resveratrol in CHO and HeLa Cell Lines
Zehra Sarıgöl, Gökçe Taner, Sevtap Aydın, Merve Bacanlı, A.Ahmet Başaran, Nurşen Başaran
P12-20
Determination of liver specific toxicities in rat hepatocytes by High Content Imaging
during 2-week multiple treatment
Germano, Davide; Uteng, Marianne; Couttet, Philippe; Grenet, Olivier; Chibout, Salah-Dine; Pognan,
Francois; Wolf, Armin
P12-21
Development of a 3D suspension culture system of umbilical cord-derived mesenchymal
stromal cells (UCX®) for potential in vitro toxicological applications
Miranda J.P., Filipe E., Filipe M., Teixeira M., Cipriano M., Barcia R., Cruz P., Cruz H., Oliveira N.G., Castro
M., Santos J.M.
Miranda J.P., Cipriano M., Fernandes A.S., Castro M. and Oliveira N.G.
P12-23
Development-dependent inflammatory response elicited by the herbicide paraquat in 3D
neural cultures
Jenny Sandström von Tobel, Jorane Althaus, Julien Mermoud and Florianne Monnet-Tschudi
P12-24
Effects of culture on polymer biomaterials on the cellular responses to chemicals
Miyajima-Tabata, Atsuko; Kato, Reiko; Sakai, Keiko; Matsuoka, Atsuko
P12-25
Effects of extended low-load operation of a non-DPF diesel engine on the relative toxicity
of its emissions
Topinka, Jan; Rossner, Pavel; Milcova, Alena; Schmuczerova, Jana; Rossnerova, Andrea; Pavlikova,
Jitka; Ambroz, Antonin; Novakova, Zuzana; Svecova, Vlasta; Vojtisek-Lom, Michal
97
Posters
P12-22
In vitro cytotoxicity assessment using three-dimensional cell cultures of MCF10A cells
P12-26
Effects of neurotoxic compounds on functional three-dimensional neural tissues derived
from hESCs.
L. Stoppini, I. Charvet, KH Krause
P12-27
Effects of Neurotoxicity on Fipronil using human cell SH-SY5Y
Young-Lim Kim, Mihye Jeong, Soo-Jin Park, Kyung-Hun Park, Jeong Eun Lee, Jae Hyun Park,
Hyun Chul Koh
P12-28
Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor
Long, Manhai; Ghisari, Mandana; Bonefeld-Jørgensen, Eva C.
P12-29
Efficiency and efficacy of using a sophisticated 3D in vitro system of the human epithelial
airway barrier to gain insight into the hazard posed by nanomaterials
Martin J. D. Clift, Carola Endes, Dimitri Vanhecke, Peter Wick, Peter Gehr, Roel P. F. Schins,
Alke Petri-Fink & Barbara Rothen-Rutishauser
P12-30
Estimation of oral mucosa toxicity using 3-D reconstructed human oral tissue model for
animal alternative
Sun-A Cho, Yin-zhu Piao, Gi-baeg Nam, Ji Hoon Kim, Mee-ju Kim, Il-Hong Bae, Kwang-Mahn Kim,
­Jun-Cheol Cho, Kyeho Shin
P12-31
Evaluating the potential of utilizing human embryonic stem cell-derived cardiomyocytes
on multielectrode array as a pre-clinical cardiotoxicity assay
Clements, Mike; Roquemore, Liz
P12-32
Evaluation of Biological Efficiency of Oxime Based Reactivators Against Organophosphate
Inhibited AChE: An In-vitro Study
Bhanushree Gupta & Kallol K. Ghosh
P12-33
Feasibility study of a new microfluidic device consisting in the coculture of intestinal and
hepatic cells
Thibault Bricks, Patrick Paullier, Marie-José Fleury, Franck Merlier, Eric Leclerc
P12-34
High throughput screening of toxicological signaling pathways using in vitro 3D epithelial
luciferase reporter models
Mankus, Courtney; Jackson, George; Armento, Alexander; Kandarova, Helena; Hayden, Patrick
P12-35
Importance of adaption-time to galactose-medium for accurate in vitro assessment of
­mitochondrial toxicity
K. Dernick, F. Boess, T. Singer, F. Schuler, A. Roth, S. Kustermann
P12-36
Importance of reproducibility demonstration of the bio-engineered tissue models used for
in vitro toxicity testing purposes.
Silvia Letasiova, Michael Bachelor, Helena Kandarova, Paul Kearney, Mitchell Klausner
98
P12-37
In Vitro Assessment of Adsorbents to Prevent Disruption of the Intestinal Barrier by Mycotoxins
A Anadón, M A Martínez, I Ares, V Castellano, M Martínez, E Ramos, M R Martínez-Larrañaga and A
Romero.
P12-38
In Vitro Cytotoxicity And Genotoxicity Testing Using Upcyte® Hepatocytes
Nörenberg, Astrid, Vera Sonntag-Buck, Nicola Hewitt, Stefan Heinz, Joris Braspenning
P12-39
In vitro effects of deoxynivalenol and β-Zearalenol alone and in combination on steroidogenesis in bovine small granulosa cells
F. Pizzo, F. Caloni, N. Schreiber, M. Totty, L.J. Spicer
P12-40
In vitro effects of fumonisin B1 on porcine granulosa cell steroidogenesis and gene expression
C. Cortinovis, F. Caloni, N. Schreiber, L.J. Spicer
P12-41
In Vitro Modeling of Cytokine-Drug Interactions Using Micropatterned Co-Cultures of Primary Hepatocytes and Kupffer Macrophages
Michael McVay, Chitra Kanchagar, Salman R. Khetani and Okechukwu Ukairo
P12-42
In vitro pituitary and thyroid cell proliferation assays and their relevance as alternatives to
animal testing
Jomaa, Barae; Aarts, Jac M.M.J.G.; de Haan, Laura H.J.; Peijinenburg, Ad A.C.M.; Bovee, Toine F.H.;
Murk, Albertinka J.; Rietjens, Ivonne M.C.M.
P12-43
In vitro studies on the neurotoxic effects of piperazine-derived designer drugs and
3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)
P12-44
Insights into mechanisms underlying inter-individual susceptibility to Drug-Induced-LiverInjury (DILI) from data on in vitro exposure, transcriptomics and functionality of cryopreserved human primary hepatocytes – The example of Chlorpromazine
Richert L, Hewitt P, Blaauboer B, Bois F, Mueller S and Annaert P
P12-45
Interindividual variation in response to xenobiotic exposure established in precision-cut
human liver slices
Marlon J.A. Jetten, Sandra M. Claessen, Cees H.C. Dejong, Agustin Lahoz, Danyel G.J. Jennen, Jos C.S.
Kleinjans, Joost H.M. van Delft
P12-46
Iron induced mitochondrial damage, which is blocked by LKB1 activation
Sang Chan Kim, Guang-Zhi Dong, Il Je Cho and Young Woo Kim,
P12-47
Roots of Erigeron annuus inhibits acute inflammatory response through NF-kB inactivation
Sang Chan Kim, Il Je Cho and Young Woo Kim
99
Posters
Popova, Dina; Forsblad, Andréas N. P.; Jacobsson, Stig O. P.
P12-48
Kinetic Studies of Cholinesterase Reactivators with Organophosphate Inhibited AChE
Rahul Sharma & Kallol K. Ghosh
P12-49
Low concentration mixtures of MDMA and its major human metabolites induce significant
toxicity to liver cells, both at physiological and hyperthermic conditions
Diana Dias da Silva, Elisabete Silva, Félix Carvalho, Helena Carmo
P12-50
Melatonin Protection against Type II Pyrethroid-Induced Cytotoxicity in SH-SY5Y, HepG2
and Caco-2 Human Cell Lines
M R Martínez-Larrañaga, M A Martínez, I Ares, V Castellano, M Martínez, E Ramos, A Anadón, and A
Romero.
P12-51
Microgravity spheroids as a reliable, long-term tool for predictive toxicology.
Stephen J. Fey and Krzysztof Wrzesinski
P12-52
miRNA profiling as a tool for developmental neurotoxicity pathway analysis in human in
­vitro model
Price, Anna; Fabbri, Marco; Sacco, Maria Grazia; Gribaldo, Laura; Pamies, David; Pallocca, Giorgia
P12-53
MiRNA-210 modulates nickel-induced hypoxic responses by repressing the iron-sulfur
­cluster assembly proteins ISCU1/2
Mindi He, Lin Mao, Zhengping Yu, Zhou Zhou
P12-54
miRNomics, metabolomics and 3D neuronal differentiation of LUHMES progenitor cells as
an in vitro model for DNT studies.
L. Smirnova, G. Harris, H. Hogberg, S. Martos, and T. Hartung
P12-55
Multicellular D Human Liver Microtissues for long-term toxicity testing
Simon Messner, Paul Walker, Wolfgang Moritz, Jens M. Kelm
P12-56
Multiple endpoint approach improves prediction of hepatotoxicity
Truisi GL, Parmentier C, Richert L, Mueller SO, Hewitt PG
P12-57
Natural Ingredients in Sensitizing Formulations Inhibit the Response of Sensitization
­Markers in Dendritic Cells
N. Lambrechts, H. Witters, J. Hooyberghs, G. Schoeters
P12-58
Optimization of the EpiOcularTM Eye Irritation Test for Hazard Identification and Labelling
of Chemicals in Response to the Requirements of the EU Cosmetic Directive and REACH
Legislation
Yulia Kaluzhny, Helena Kandarova, Laurence d’Argembeau-Thornton, Jane De Luca, Patrick Hayden,
Amy Hunter, Thoa Truong, and Mitchell Klausner.
P12-59
Organotypic human oral tissue models for toxicological studies
Bridget Breyfogle, Silvia Letasiova, Patrick Hayden and Mitchell Klausner
100
P12-60
Perfluorinated compounds affect the function of sex hormone receptors
Kjeldsen, Lisbeth Stigaard; Bonefeld-Jorgensen, Eva Cecilie
P12-61
Pharmacodynamic profiling of EGFR inhibitors in human keratinocytes
Balavenkatraman KK, Vicart A, Couttet P, Ledieu D, Hopfer U, Rathfelder N, Bertschi B, Greutmann B,
Marcellin M, Chibout SD, Lambert A, Moggs J, Pognan F, Wolf A
P12-62
Piperazine designer drugs present cytotoxicity to primary rat hepatocytes
Marcelo Dutra Arbo, Simone Melega, Markus Schug, Regina Stöber, Jan Hengstler, Maria de Lourdes
Bastos, Helena Carmo.
P12-63
Precision-cut intestinal slices as an in vitro model to predict NSAID induced intestinal
­toxicity
Niu, Xiaoyu; van der Bijl, Henk; Groothuis, Geny; de Graaf, Inge
P12-64
Prediction of Drug-Induced Liver Injury in Human with a Multiparametric Assay on the
­HepaRG® Cell Line
Nelly Buron, Mathieu Porceddu, Célestin Roussel, Pierre Rustin, Sandrine Camus, Bernard Fromenty
and Annie Borgne-Sanchez
P12-65
Predictive Human Kidney-Specific In Vitro Models
Yao Li, Zay Yar Oo, Wei Seong Toh, and Daniele Zink
P12-66
Prevalidation of the CULTEX® method (BMBF project 0315710):
The air-liquid interface exposure of human lung cells in the CULTEX® Radial Flow System
(RFS)
Niklas Möhle, Dirk Steinritz, Christine Pohl, Sebastian Hoffmann, Michaela Aufderheide
P12-67
Primary cells derived from the non-human primate
P12-68
Protective effect of traditional African vegetable (Amaranthus hybridus) against aflatoxin
B1 and/or fumonisin B1 in a rat hepatoma cell-line
Mohamed I.M. Ibrahim, Rialet Pieters, A.M. van der Walt, Cornelius C. Bezuidenhout, Skeina H.
Abdel-Azeim, Mosaad, A. Abdel-wahhab
P12-69
Protective Effects of Boron Compounds against Metal Induced Genotoxicity in V79 Cells
Aylin Üstündağ, Claudia Behm, Wolfram Föllmann, Yalçın Duydu, Gisela H. Degen
P12-70
Rat neuronal microtissues for toxicity testing
David A. Fluri, Rosemarie Marchan, Simon Messner, Jan G. Hengstler and Jens M. Kelm
P12-71
Relevance of in-vitro methods for the evaluation of eye and skin irritation/corrosion
­potential of aliphatic tertiary amines
Li, Qiang; Kreiling, Reinhard
101
Posters
S Grote-Wessels, R v Laer, B Niggemann
P12-72
Saussurea Lappa induce apoptosis in HL-60 cells via activation of JNK and inhibition of
ERK1/2
Su Jin Kang, Sae Kwang Ku, Young Joon Lee
P12-73
Sestrin2 Induction by Nrf2 Is Essential for the Protection against Oxidative Damage in
­Hepatocytes
Il Je Cho, Young Woo Kim, Sung Hwan Ki, and Sang Chan Kim
P12-74
Skin irritation using VitroDerm model for the personal care products classification:
Internal validation process
Ficheux, Hervé; Catoire, Sophie; Lopez, Fabiola
P12-75
Systems-Toxicology Approach to Evaluate the Biological Impact of a Subset of Harmful/
Potentially Harmful Constituents of Tobacco Smoke
Ignacio Gonzalez-Suarez, Carole Mathis, Emmanuel Guedj, Paul Walker, Samantha Ellis, Heather Woodhouse, Remi Dulize, Sandra Wagner, Florian Martin, Nikolai Ivanov, Julia Hoeng, Manuel C. Peitsch
P12-76
The effect of environmentally relevant concentration of selected PPCPs on fish cell lines
J. Kolarova, V. Zlabek, R. Grabic, O. Golovko, K. Grabicova, V. Burkina, T. Randak
P12-77
The effect of selected furanocoumarins on the spontaneous motoric activity of rat isolated intestine strips
Mendel, Marta; Chlopecka, Magdalena; Dziekan, Natalia; Karlik, Wojciech; Skalicka-Wozniak, Krystyna
P12-78
The gastrointestinal uptake of TiO2 nanoparticles and associated toxicity
Gitrowski, Constantinos; Al-Jubory, Aliaa; Handy, Richard
P12-79
The importance of understanding drivers of irritation in vivo for selection of chemicals
used in the development and evaluation of in vitro eye irritation assays: Cosmetics Europe
analysis
Barroso J, Alépée N, De Smedt A, De Wever B, Hibatallah, J, McNamee P, Mewes K, Millet M,
­Pfannenbecker U, Tailhardat M, Templier M
P12-80
The survival of murine dendritic cells is controlled by the transcriptional factor Nrf2 in
­response to contact sensitizers.
Zeina El Ali, Marc Pallardy and Saadia Kerdine-Römer
P12-81
The use of Real-Time Cell Analyzer (RTCA) in In Vitro Toxicology
S. Barcellini-Couget, G. de Sousa, R. Rahmani
P12-82
Toxicity of cadmium chloride in a 28-day repeated exposure human bronchial epithelial
cell model
Emma Bishop, Damien Breheny, Debbie Dillon & Clive Meredith
102
P12-83
Trimetyltin promotes neuroinflammation and enhances 11β-hydroxysteroid
­dehydrogenase 1 expression in microglial cells isolated and in an histotypic context
Boonrat Chantong, Fanny Zuffery, Tania Dos Santos, Florianne Tschudi-Monnet and Alex Odermatt
P12-84
Use of ‘same donor’ endothelial cells and PBMC in co-culture to detect cytokine storm
­reactions to a TGN1412-like anti-CD28 antibody: A novel assay for biologic drug safety
screening
Reed, Daniel; Gashaw, Hime; Bailey, Lucy; Paschalaki, Koralia; Starke, Richard; Randi, Anna; Hansel,
Trevor; Mitchell, Jane
P12-85
Using transcriptomics from a human hepatocyte cell line to predict pesticide genotoxicity
and carcinogenicity: Comparing gene- and pathway-based classifiers
Cavill, Rachel; Brauers, Karen; Kleinjans, Jos; Briedé, Jacob-Jan
P12-86
Utilization of Hormone Responsive Cell Lines for Identification of Endocrine Disrupting
Chemicals
Yama Abassi, Can Jin, Melinda Stampfl, Xiao Xu, Xiaobo Wang
P12-87
Vaccinium Myrtillus extract protects against UVA- and UVB- induced damage in HaCaT
­keratinocytes
Calo’, Rossella; Lo Scalzo, Roberto; Marabini, Laura
P12-88
Validation of high throughput 2D hepatocyte, micro-patterned co-cultured hepatocyte,
and 3D hepatocyte spheroid models for prediction of rodent and human liver toxicity
Xiaoman Ang, Thomas Sachnik, Alex Odermatt, Adrian B. Roth, Claudia McGinnis
P12-89
Vitrigel-EIT (eye irritancy test) methods provide a brief assay system for estimating the
changes of barrier function and architecture after exposing test chemicals to a human
­corneal epithelium model
P13: Mechanisms of Toxicities
P13-01
“Ecstasy” impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3β
Daniel José Barbosa, Romàn Serrat, Serena Mirra, Marti Quevedo, Elena Gomez de Barreda, Jesús Àvila,
Eduarda Fernandes, Maria de Lourdes Bastos, João Paulo Capela, Félix Carvalho, and Eduardo Soriano
P13-02
Alterations in Survivin and Caspase-3 Expressions after Hypericin Mediated PDT in HT-29
and Caco-2 Cells
Aysun Kiliç Süloğlu, Çağatay Karaaslan, Elif Karacaoğlu, Güldeniz Selmanoğlu
P13-03
Association between δ-aminolevulinic Acid Dehydratase Polymorphism and Placental Lead
Levels
Tülin Söylemezoğlu, Zeliha Kayaaltı, Dilek (Kaya) Akyüzlü, Esma Söylemez, Selda Sert
103
Posters
Yamaguchi, Hiroyuki; Kojima, Hajime; Takezawa, Toshiaki
P13-04
CAR-mediated, rodent-specific, mechanism of liver foci formation: evidence from 8-day KO
mouse study
Hoflack JC, Niederhauser U, Flint N, Lenz B, Herrmann A, Boess F, Singer T & Roth A
P13-05
Chronic Toxicity Study of benzaldehyde semicarbazone in rats: alterations in liver and
bones
Vieira, Andrea; Vieira, Rafael; Cassali, Geovanni; Galassi, Carolina; Beraldo, Heloisa; Taligati, Carlos
P13-06
Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and
­synergistic toxicity with zinc
Carole Bresson, Carine Darolles, Asuncion Carmona, Céline Gautier, Nicole Sage, Stéphane Roudeau,
Richard Ortega, Eric Ansoborlo, Véronique Malard
P13-07
Dibutyltin blocks metabotropic glutamate receptor mGluR5 signaling resulting in
­increased intracellular calcium and endoplasmic reticulum stress in mouse BV-2 microglia
cells
Boonrat Chantong and Alex Odermatt
P13-08
Endocrine modulatory effects of cadmium and the molecular mechanism of action
Imran Ali, Pauliina Damdimopoulou, Ulla Stenius and Krister Halldin
P13-09
Epoxyeicosatrienoic acids modulate amyloid precursor protein (APP) processing in vitro
Mule, Nandkishor; Arand, Michael; Cronin, Annette; Kollar, Sarah; Marowsky, Anne
P13-10
Evaluation of Rats Liver Damage Degree Following Administration of Different Antituberculosis Medicines Combinations
S. Anisimova, G. Shayakhmetova, L. Bondarenko, A. Voronina, V. Kovalenko
P13-11
HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin
Wuillemin, Natascha; Adam, Jacqueline; Fontana, Stefano; Kraehenbuehl, Stephan; Yerly, Daniel;
Pichler, Werner J.
P13-12
Increased Hypothalamic Dopaminergic Neuron Tyrosine Hydroxylase Expression in Lean
Wistar Rats
Simon M. Plummer, Mariana Beltran, Laura Aitken, Mike Millar, Rolly Wiegand, and Jayne Wright.
P13-13
Interaction between mercury compounds and selenium and its effects on the activity and
expression of thioredoxin and thioredoxin reductase in liver cells.
Vasco Branco, Ana G. Santos, Juan Rodrigues, João Gonçalves, Jun Lu, Arne Holmgren, Cristina Carvalho
P13-14
Interactions of signaling through the aryl hydrocarbon receptor and the β-catenin pathway
in the regulation of CYP1A1 expression
Albert Braeuning, Pascal Schulthess, Alexandra Löffler, Nils Blüthgen, Michael Schwarz
104
P13-15
Key scientific issues relevant to the identification and characterisation of endocrine
­disrupting substances – Report of the Endocrine Disrupters Expert Advisory Group
Sharon Munn, Marina Goumenou
P13-16
Mitochondrial impairment after mitoxantrone multi-administration to Male Wistar rats
Fernando Remião, Luciana Grazziotin Rossato, Eliane Dallegrave, Marcelo Arbo, Renata Silva, Rita
­Ferreira, Francisco Amado, Ricardo JorgeDinis-Oliveira, José Alberto Duarte, Maria de Lourdes Bastos,
Carlos Palmeira, and Vera Marisa Costa
P13-17
Modulation of sphingolipid metabolism and alterations of membrane proteins by dioxinand non-dioxin-like toxicants in liver progenitor cells
M. Machala, J. Slavik, K Pencikova, J. Vondracek
P13-18
Quercetin effectiveness in the prevention of pathological processes at the metabolic
­syndrome
Rushchak, Volodymyr; Voronina, Alla; Shayakhmetova, Anna; Chashchyn, Mykola
P13-19
Polyphenolic compounds from Aronia melanocarpa berries protect from hydrogen
­peroxide accumulation in the bone tissue of cadmium-exposed rats
Roszczenko, Alicja; Brzóska, Malgorzata M.; Rogalska, Joanna
P13-20
Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis
­elegans
Vivian Hsiu-Chuan Liao, Wen-Hsuan Li, Yeu-Ching Shi, I-Ling Tseng
P13-21
Protein Kinase C Inhibition Induced Steroid Hormonal Perturbation in Rat in vivo
Schadt Heiko, Dincer Zuhal, Schwald Marianne, Dietz Audrey, Ledieu David, Cordier Andre, Papoutsi
Maria, Junker Walker Ursula, Spence Fiona, Chibout Salah-Dine, Wolf Armin, Pognan Francois
P13-22
Quantum mechanical, In Vitro and In Vivo Evidence of the Involvement of Non-Bonding
­Nitrogen Interactions in Valine Derived β- amino Chalcogenides
Posters
Waseem Hassan, Senthil Narayanaperumal, Kashif Gul, Rogério de Aquino Saraiva,
Antonio L. Braga, Oscar E.D. Rodrigues and João Batista Teixeira da Rocha
P13-23
Structure-activity studies on the RXR agonist activity of organotins
Nakanishi, Tsuyoshi; Hiromori, Youhei; Nishikawa, Jun-ichi; Nagase, Hisamitsu
P13-24
Tributyltin-induced endoplasmic reticulum stress and its mechanism
Kotake, Yaichiro; Isomura, Midori; Masuda, Kyoichi; Miyara, Masatsugu; Okuda, Katsuhiro; Samizo,
Shigeyoshi; Sanoh, Seigo; Hosoi, Toru; Ozawa, koichiro; Ohta, Shigeru
P13-25
Zinc supplementation protects from cadmium-induced oxidative stress in the brain of rats
Brzóska, Malgorzata M.; Rogalska, Joanna; Galazyn-Sidorczuk, Malgorzata
105
P14: Metabolism and kinetics
P14-01
3D hepatocyte cultures: a useful tool in the study of Nevirapine bioactivation and toxicity
Miranda J.P., Pinheiro P.F., Marinho A.T., Harjivan S.G., Castro M., Pereira S.A., Antunes A.M.M.,
Marques M.M.
P14-02
Consumption of foods containing cyanogenic glycosides: A study on bioavailability of
cyanide in humans
Abraham K, Buhrke T, Lampen A
P14-03
Determination of urinary butoxyacetic acid (2-BAA) in rat treated with diethyleneglycoldibutylether (DEGDBE) for the purpose of read-across hazard assessment
Lee, Moung Sook; Grimm, Andreas; Kreiling, Reinhard
P14-04
Differences in detoxification of the ultimate carcinogenic dihydrodiol epoxides of benzo[a]
pyrene and dibenzo[a,l]pyrene in human Caco-2 cells
Hessel, Stefanie; John, Andrea; Seidel, Albrecht; Lampen, Alfonso
P14-05
Effect of maternal vitamin D receptor FokI single-nucleotide polymorphism on the
­placental lead level
Tülin Söylemezoğlu, Zeliha Kayaalti, Dilek (Kaya) Akyüzlü, Esma Söylemez, Deniz Koca
P14-06
Effects of single or repeated Bojungikkitang (BJIKT) administration, a polyherbal formula,
on pharmacokinetics of gefitinib in rats
Soo-Jin Park, Jong-Dae Kim, Dae-Sung Hyun, Su-Yeon Cho, Sae-Kwang Ku
P14-07
Effects of single or repeated Jaeumkanghwatang (JEKHT) administration, a polyherbal
formula, on pharmacokinetics of tamoxifen in rats
Soo-Jin Park, Young-Sun Park, Sung-Hwan Park, Sang-Chan Kim, Su-Yeon Cho, Sae-Kwang Ku
P14-08
Effects of single or repeated Kongjindan (KJD) administration, a polyherbal formula, on
pharmacokinetics of donepezil in rats
Soo-Jin Park, Oh Dae Kwon, Dae-Kyoo Chung, Su-Yeon Cho, Sae-Kwang Ku
P14-09
Effects of single or repeated Chungsinoryungsan (CSORS) administration, a polyherbal
­formula, on pharmacokinetics of perindopril in rats
Soo-Jin Park, Seok-Bong Kang, Ho-Sang Shon, Su-Yeon Cho, Sae-Kwang Ku
P14-10
Effects of single or repeated Ijintanggamibang (IJTGMB) administration, a polyherbal
­formula, on pharmacokinetics of ondansetron in rats
Soo-Jin Park, Dae-Jun Kim, Ryu Hyun-Mo, Su-Yeon Cho, Sae-Kwang Ku
P14-11
Effects of single or repeated Kongjindan (KJD) administration, a polyherbal formula, on
pharmacokinetics of sorafenib in rats
Soo-Jin Park, Seung-Mo Kim, Chang Hyeong Lee, Sang-Chan Kim, Su-Yeon Cho, Sae-Kwang Ku
106
P14-12
Experimental investigation of chrome accumulation kinetics in the animal organism
Gumarova Zh.Zh., Bekmukhambetov Ye.Zh., Jarkenov T.A.
P14-13
FRET-based analysis of the interaction between mEH and CYP
Anette Orjuela, Michael Arand
P14-14
Genetic Variations of MT2A Gene are Associated with Arsenic Levels in Biological Samples
of Individuals Occupationally Exposed to Arsenic
Dilek (Kaya) Akyüzlü, Zeliha Kayaaltı, Esma Söylemez, Vugar Ali Türksoy, Engin Tutkun, Tülin
Söylemezoğlu
P14-15
Maternal hemochromatosis gene H63D single-nucleotide polymorphism and placental
lead levels
Dilek (Kaya) Akyüzlü, Zeliha Kayaaltı, Esma Söylemez, Sinem Işık, Tülin Söylemezoğlu
P14-16
Interindividual Variability in Generating Acetaminophen Reactive Metabolite NAPQI by
Various Human Liver and Kidney Microsomes
Ege Arzuk, Burak Turna, Murat Sözbilen, Hilmi Orhan
P14-17
Metabolic and thermoregulatory effects of skin versus diet L-menthol treatment
Angelica Valente, Athanasios Z. Jamurtas, Eleutheria Theodoropoulou, Elena Vakonaki, Maria
­Christakis-Hampsas, Stavros Pantelakos, Manolis Tzatzarakis, Aristidis Tsatsakis, Andreas D. Flouris
P14-18
P-glycoprotein expression and activity are differently modulated by Colchicine in Caco-2
cells: in vitro and in silico studies
Fernando Remião, Renata Silva, Vânia Vilas-Boas, Daniel José Barbosa, Andreia Palmeira, Emília Sousa,
Félix Carvalho, Maria de Lourdes Bastos and Helena Carmo
P14-19
Participation of Mammalian Gut Bacteria in Metabolism of Natumetone
Anzenbacherova, Eva; Anzenbacher, Pavel; Matuskova, Zuzana; Kolár, Milan; Tlaskalova-Hogenova,
­Helena
Posters
P14-20
Pharmacokinetics and percutaneous absorption of benzophenone-3 from sunscreen
­formulations in rats
Tae Hwan Kim, Sung Ha Ryu, Beom Soo Shin, Sun Dong Yoo, Kyu-Bong Kim
P14-21
Pharmacokinetics and tissue distribution of acrylamide and its active metabolite,
­glycidamide in rats
Kyu-Bong Kim, Sung Ha Ryu, Ji Won Kim, Beom Soo Shin
P14-22
Pharmacokinetics and tissue distribution of benzophenone-3, a UV filtering agent in rats
Tae Hwan Kim, Sung Ha Ryu, Beom Soo Shin, Sun Dong Yoo, Kyu-Bong Kim
P14-23
Polyphenolic compounds from Aronia melanocarpa berries protect from cadmium
­accumulation in the liver and kidney of rats
Brzóska, Malgorzata M.; Galazyn-Sidorczuk, Malgorzata; Jurczuk, Maria
107
P14-24
Rational design of novel CYP2A6 inhibitors
Raunio, Hannu; Tani, Niina; Juvonen, Risto; Fashe, Muluneh; Leppänen, Jukka; Zhao, Bin; Miksys,
Sharon; Tyndale, Rachel; Rahnasto-Rilla, Minna
P14-25
Reactivity and risk assessment of CoA-conjugated carboxylic acid drugs
Malin Darnell and Lars Weidolf
P14-26
Study of Intracellular Reaction and Diffusion Mechanism of Carcinogenic PAH:s Using
­Non-Standard Compartment Modeling Approach
Qasim A. Chaudhry, Michael Hanke
P14-27
The role of rat and human CYP enzymes in okadaic acid-associated toxicity
Kolrep, Franziska; Hessel, Stefanie; Ehlers, Anke; Lampen, Alfonso
P14-28
Toxicokinetics of sub-nanomaterials following oral administration for safety evaluation
Higashisaka, Kazuma; Uji, Miyuki; Yamaguchi, Manami; Mori, Takahide; Misato, Kazuki; Tsunoda,
Shin-ichi; Yoshioka, Yasuo; Tsutsumi, Yasuo
P20: Risk Assessment
P20-01
A case study of risk assessment in Malaysia
Thannimalay, Letchumi
P20-02
An In Vitro Model for Predicting Penetration of Polyethylene Glycols ([14C]-PEG 7
­Phosphate) through Intact, Moderately and Highly Compromised Skin
Helga Rothe, Swatee Dey, Leanne Page, Robert O’Connor, Sara Farahmand, Frank Toner, and Shaoying
Zhou
P20-03
Animal-Free Studies in Cosmetic Ingredient Industry: Perspective and Strategy after a
10-Year Experience
Ficheux, Herve; Catoire, Sophie; Lopez, Fabiola
P20-04
Assessment of endocrine disrupting effects of inorganic arsenic
Gutu, Claudia Maria; Purdel, Carmen Nicoleta; Gubandru, Miriana; Ilie, Mihaela; Balalau, Dan
P20-05
Assessment of health risks of high levels of arsenic in drinking water. The Romanian
­experience.
Nicola, Claudia; Ilie, Mihaela; Purdel, Nicoleta Carmen
P20-06
Asymmetric phthalates – a special case for risk assessment
Ulrike Bernauer, Agnes Schulte, Monika Moeder, Steffi Schrader, Thorsten Reemtsma
108
P20-07
Correlation between styrene concentration in saliva and blood samples for the biological
monitoring of occupational exposure
Monica Gherardi, Giovanna Tranfo, Maria Pia Gatto, Andrea Gordiani, Enrico Paci, Bruno Papaleo
P20-08
Determination of operator’s external exposure to deltamethrin used in vector control in
French Guyana
Norvès, Benoit; Pontal, Pierre-Gérard
P20-09
Development of cumulative and aggregate risk assessment models for human health
Dalzell, Abigail; Glass, Richard; Kennedy, Marc
P20-10
Extrapolation of toxicology endpoint data in developing integrated human and
­environmental risk assessments
Dalzell, Abigail; Glass, Richard
P20-11
Dinitrosopiperazine (DNPZ) and N-nitrosopiperazine (NPZ): Toxicological properties and
acceptable exposure levels for the general population
Ledirac, Nathalie; Bossard, Camille; Bertomeu, Lisa; Pontal, Pierre-Gérard
P20-12
EFSA’s Qualified Presumption of Safety (QPS) risk assessment approach reduces
­toxicological data requirements
Renata Leuschner, Rosella Brozzi, Frédérique Istace and Anne Theobald
P20-13
Estimation of Benchmark Dose for Thyroid Hormone Levels in Rats Exposed to Prolonged
Cadmium Intoxication
Aleksandra Buha, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić, Vesna Jaćević, Slavica Vučinić,
Vesna Matović
Buha, Aleksandra; Filipovic, Angelina; Dumanovic, Jelena; Antonijevic, Evica; Curcic, Marijana; Jankovic,
Saša; Nikolic, Dragica; Antonijevic, Biljana
P20-15
Evaluating and comparing some current environmental toxicity prediction models for the
use of preparing for Korean Act on registration and evaluation of chemicals
Kim, Kwang-Yon; Cha, Ji Young; No, Kyoung Tai
P20-16
Exposure data for family care products
Galonnier, Maude; Gomez-Berrada, Marie-Pierre; Guillou, Sonia; Rielland, Aurelie; De Javel, ­Dominique;
Ferret, Pierre-Jacques
P20-17
Exposure to dish washing liquid evaluated in Brest university population: a preliminary study.
A. Ramirez-Martinez, N. Wesolek, D. Parent-Massin, A.C. Roudot
109
Posters
P20-14
The Use of @Risk Software for Risk Assessment of Mercury Intake via Marine Food among
Serbian Population
P20-18
Facilitating the use of non-standard in vivo studies in health risk assessment – a proposal
to improve evaluation criteria and reporting
Molander, Linda; Beronius, Anna; Rudén, Christina; Hanberg, Annika
P20-19
Feasibility study: New selection rules for the TTC concept based on experimental and in
silico data
Hauge-Nilsen, Kristin; Keller, Detlef
P20-20
Human Biomonitoring of Parabens in Korean Children’s Urine
Seung-Youl Lee, Min-Sik Kyung, Song-Yi Park, Hee-Seok Lee, Min-Ki Shin, Ahra Ko, Ji-Young Kim,
­Sang-yub Kim, Young-Mi Jang
P20-21
In vitro risk assessment of hypersensitivity-causing drugs
Buenter, Antonia; Wuillemin, Natascha; Adam, Jacqueline; Yun, James; Yerly, Daniel; Dörig, Dario;
­Pecaric Petkovic, Tatjana; Pichler, Werner J.
P20-22
(Cancelled)
P20-23
International Training Programme in Health Risk Assessment
P20-24
Life-cycle toxicity assessment of Caenorhabditis elegans exposed to selenium
Vivian H.-C. Liao, Wen-Hsuan Li, Yun-Ru Ju
P20-25
Occupational Risk Assessment: threshold and non-threshold models for the mutagenic
­effect of epoxides and consequences for the determination of a virtual safe dose
Fröhlicher Mirjam, Sagelsdorf Peter, Arand Michael and Dollenmeier Peter
P20-26
Phytoestrogen aglycones but not glucuronides were found estrogenic in in vitro models
Leeuwen, F. X. Rolaf van; Rietjens, Ivonne M. C. M.; Murk, Albertinka J.
P20-27
Post hoc ergo propter hoc? – the CIOMS scale to differentiate time and causal association
in hepatotoxicity
Johannes Schulze and Rolf Teschke
P20-28
Probabilistic exposure assessment to nail cosmetics by French consumers
Morisset, Typhaine; Ficheux, Anne-Sophie; Postic, Cindy; Chevillotte, Grégoire; Roudot, Alain-Claude
P20-29
Quantitative Risk Assessment for Infant and Children’s products based on Child Specific
Exposure Considerations
Kirsch, Taryn; Felter, Susan
P20-30
Refined animal toxicity testing using unequally sized dose groups and Benchmark dose
analysis
Öberg, Mattias; Ringblom, Joakim; Kalantari, Fereshteh; Johanson, Gunnar
110
P20-31
Risk and Nutritional Assessment of Toxic (Hg, Cd, Pb, Sn and As) and Essential Elements
(Cu, Mn, Se and Zn) in Fish and Shellfish Samples
Gil F, Olmedo P, Pla A, Hernández AF, Molina-Villalba I
P20-32
Risk assessment based on computer-aided and bibliographical methods of a homeopathic
preparation from Pulsatilla pratensis L. as an example
Merz, Karl-Heinz; Jochims, Karin; Schrenk, Dieter
P20-33
Risk assessment for hazardous substances contained in household product-cleaner and
wet-tissue
Park, KunHo; Park, Junghyun; Kim, Chan-Kook; Shin, Jihye; Lee, Jong-Hyeon
P20-34
SAR- and analogue based safety assessments of cosmetic ingredients
Petry, Thomas; Jeronimo-Roque, Daniela; Tencalla, Francesca; Mishra, Sanghamitra
P20-35
The PCB effect database: a tool for translational research and health risk assessment
Hellgren, Dennis; Wu, Jianyao; Roos, Robert; Westerholm, Emma; Adfeldt-Still, Oliver; Andersson,
Patrik; Halldin, Krister; Håkansson, Helen
P20-36
Toxicogenomics to group environmental chemicals in vitro?
Ignarski, Alessa; Legradi, Jessica; Legler, Juliette; Segner, Helmut
P20-37
Toxicological evaluation of LASSBio-596: in vitro and in vivo
Araujo, G.L.; Vieira, A.E.D., Barreiro, Eliezer J, Lima, Lidia M., Cardoso, C.N.; Emiliano, N.F.; Martins, M.T.;
Souza, S.S.; Soares, S., Tagliati C. A.
P20-38
TTC: A new concept for inhalation exposure
Escher, Sylvia; Tluczkiewicz, Inga; Kühne, Ralph; Ebert, Ralf-Uwe; Schüürmann, Gerrit; Mangelsdorf, Inge
Posters
P21: Safety Assessment of Mixtures
P21-01
A low dose chemical mixture modulates the effect of PFNA in male rats
Hadrup, Niels; Skov, Kasper; Taxvig, Camilla; Frandsen, Henrik; Vinggaard, Anne Marie
P21-02
Hemostatic activity screening and skin toxicity of sap of Jatropha multifida L.
­(Euphorbiaceae) used in traditional medicine (Benin)
Dougnon Tamègnon Victorien, Klotoé Jean Robert, Dougnon Tossou Jacques, Sègbo Julien, Atègbo
Jean-Marc, Loko Frédéric, Dramane Karim
P21-03
Safety of green coffee oil in cosmetic formulations: from in vitro to clinical studies
Tais A. L. Wagemaker,; Ana Sofia Fernandes,; Catarina Rosado; Patricia Rijo,; Patricia Maia Campos;
Luis M. Rodrigues,
111
Concert Hall
P18: Regulatory Toxicology
P18-01
A prototype for integrating toxicokinetics into the human health risk assessment process
for agrochemicals: sulfoxaflor
Terry, Claire; Aggarwal, Manoj; McCoy, Alene; McFadden, Lisa; Bartels, Michael; Billington, Richard
P18-02
Mode of Action Analysis of Decreased Neonatal Rat Survival Induced by In Utero Exposure
to Sulfoxaflor
Claire Terry, Robert G. Ellis-Hutchings, Sue Marty, Reza J. Rasoulpour, Valerie Marshall, Edward W.
­Carney, and Richard Billington
P18-03
Alternative Method in practice: postvalidation experience of the skin sensitization in vitro
test strategy
Susanne N. Kolle, Annette Mehling, Wera Teubner, Bennard van Ravenzwaay and Robert Landsiedel
P18-04
Applicability of in silico models for the prediction of the sensitization potential of
­industrial chemicals
Wera Teubner, Annette Mehling, Paul Xaver Schuster, Katharina Guth, Andrew Worth, Julien Burton,
Bennard van Ravenzwaay, Robert Landsiedel
P18-05
Assessment factors for susceptible populations analysis of airway response during
­short-term exposure to airborne chemicals
Öberg, Mattias; Johansson, Mia; Johanson, Gunnar
P18-06
Assessment of the subchronic and developmental toxicity of sodium-dimethyl-5-sulphonatoisophthalate (CAS 3965-55-7) in a weight of evidence approach
Roth, Thomas; Jensch, Udo; Volz, Nadine
P18-07
Comparison of methods for calculation of carry-over limits and their values with
­occupational exposure limits
Lovsin Barle, Ester; Cudd, Margaret Amelia; Bechter, Rudolf; Gian Christian, Winkler
P18-08
Derivation of a Guidance Limit for Cadmium in Children’s Jewellery: Health Canada’s
­Perspective
John Field, Pierre Chantal, Sandra Wright, Paul Chowhan, Patricia Pelletier, Helen Ryan, and Gordon
Barrett
P18-09
Draize test for eye irritation: importance of the endpoints evaluated with regard to UN
GHS / EU CLP classification
Adriaens, Els; Barroso, João; Eskes, Chantra; Hoffmann, Sebastian; McNamee, Pauline; Alépée,
Nathalie; Bessou-Touya, Sandrine; De Smedt, Ann; de Wever, Bart; Pfannenbecker, Uwe; Tailhardat,
Magalie; Kirmizidis, George; Zuang, Valérie
112
P18-10
Gender-related difference in the toxic susceptibility of rats to an ultraviolet absorber,
2-(2’-hydroxy-3’,5’-di-tert-butylphenyl)benzotriazole: a role of peroxisome proliferator-­
activated receptor (PPAR) alpha
Ono, Atsushi; Hirata-Koizumi, Mutsuko; Ise, Ryota; Kato, Hirohito; Matsuyama, Takashi; Ema, Makoto;
Hirose, Akihiko
P18-11
Trend Analysis of Body Weights, Survival, and Tumor Incidence, and the Effect of Body
Weight on the Incidence of Spontaneous Tumors in Tg.rasH2 Mice
Elbekai, Reem; Paranjpe, Madhav
P18-12
Historical Control Data of Neoplastic Lesions in Transgenic CBYB6F1-Tg(HRAS)2Jic
(Tg.rasH2) Mice
Paranjpe, Madhav; Elbekai, Reem
P18-13
Historical Control Database of Non-Neoplastic Lesions in Transgenic CBYB6F1-g(HRAS)2Jic
(Tg.rasH2) Mice
Elbekai, Reem; Paranjpe, Madhav
P18-14
Improving the Quality of Cardiovascular and Respiratory Endpoints in Toxicology Studies
Crome SJ, Broadmeadow A, Meecham K
P18-15
Legal principles for handling information deficits in REACH
Zetterberg, Charlotta; Nilsson, Charlotte; Håkansson, Helen
P18-16
Less is More: Better Toxicity Data from fewer Rodents using Plasma Microsampling
Anne Eichinger-Chapelon, Daniela Zaugg, Georg Schmitt and Thomas Singer
P18-17
Likeliness of false positive finding in Local Lymph Node Assay with Diethyleneglycoldibutylether
P18-18
Non-animal approaches to assessing the skin sensitization endpoint under REACH
Thomas Petry, Nirmala Ranggasami and Francesca Tencalla
P18-19
Non-experimental alternative methods for the hazard evaluation of cosmetics and chemicals
Carole Charmeau, Nathalie Ledirac, Laëtitia Fiévez-Fournier, Muriel Danten, Aurélie Sevestre
P18-20
Overview of the Existing Regulations and Testing Programs for Endocrine Active Chemicals
Simon Warren, Elaine Freeman, Julian Reddy
P18-21
Ranking of epoxy resin compounds based on their sensitising potency
Schuhmacher-Wolz, Ulrike; Heine, Karin; Geier, Johannes; Kalberlah, Fritz
113
Posters
Lee, Moung Sook; Kreiling, Reinhard
P18-22
Relationship between mortality and dosage scheme as key issue in the design of
­regulatory toxicological studies of different types of human insulin analogs
Kupny, Joanna; Mrzyk, Inga; Sornat, Robert; Drzewiecka, Agnieszka; Kropidlo, Aneta; Gruszka,
­Katarzyna; Szewczyk, Aleksandra; Pawlowska, Monika; Bogiel, Monika; Borowicz, Piotr
P18-23
Reproductive toxicity of azole fungicides from a regulatory perspective
Myöhänen K., Broeckaert F., Court Marques D., Lapenna S., Maggiore A., Spjuth L., Huuskonen H.
P18-24
Role of Post-Translational Modifications in a Function of Pregnane X Receptor
Vavrova A., Vrzal R., Dvorak Z.
P18-25
Safety assessment of Hwangryunhaedok-tang: subchronic toxicity study in Crl:CD
Sprague Dawley rats
Lee, Meeyoung; Seo, Changseob; Kim, Young bum; Shin, Hyeunkyoo
P18-26
Tumour and cumulative mortality information in oral tumorigenicity studies in the CD 1
mouse between 1995 and 2011
Broadmeadow, Alan; Crome, Steve; Webley, Lisa; Taylor, Ian
P18-27
Vaccines Europe reflection paper on the Safety Assessment of Residuals and
­Contaminants in Vaccines
Damsten, Micaela; Segal, Lawrence; Gould, Sarah; Finkelstein, Martin; Frantz, Christopher; Geuns, Ed;
Herzyk, Danuta; Mulder, Mariska; Novicki, Deborah; Smith, Thomas
P23: Target Organ Toxicities
P23-01
‘Ecstasy’ and amphetamine neurotoxicity to cultured rat cortical neurons in a continuous
exposure model
Silvana da Costa Araújo, Vera Marisa Costa, Frederico C. Pereira, Eduarda Fernandes, Maria de Lourdes
Bastos, Félix Dias Carvalho, João Paulo Capela,
P23-02
A novel zebrafish model to predict organ toxicities in mammals
Ingham, Philip; Wang, Xingang; Wang, Haishan; Kaur, Navrinder; Mathavan, Sinnakaruppan; Fowler,
Stephen; Weiser, Thomas; Cohen, Stephen; McGinnis, Claudia
P23-03
Acrylamide induced chronic nephrotoxicity in rats
Raoufi, Ahmad, jamshidi, keivan
P23-04
Chloracne/MADISH-like cystic lesions after low-dose exposure to dioxin:
A histological study of 43 cases
Nikolina Saxer-Sekulic, Gürkan Kaya, Jean-Hilaire Saurat, Olivier Sorg
P23-05
Comparison of the accumulation of ochratoxin A residues in treated pig tissues
Jelka Pleadina, Nina Peršia, Dragan Kovačevićb, Ana Vulića, Dinka Milićc
114
P23-06
Evaluation of zebrafish larvae as alternative test system to predict hepatotoxicity
S. Verstraelen, A. Covaci, W. Maho, P. Berckmans, B. Peers, H. Witters
P23-07
Full-field electroretinogram recording in the Göttingen minipig
Haag, Valérie; Forster, Roy; Augsburger, Anne-Sandrine
P23-08
Gene expression of mitotic reorientation on rat prostate epithelial cells exposed to
­subchronic testosterone
Liu, Xiang-yun; Xu, Li; Li, Lei; Cheng, Yi; Shao, Yue; Yang, Jian-yan; Sun, Zu-yue
P23-09
Heat shock protein 90 inhibitor, TAS-116, demonstrates favorable tissue distribution
­profiles and leads to minimized ocular toxicity
Hitotsumachi, Hiroko; Kodama, Yasuo; Ohkubo, Shuichi; Besshi, Kazuhiko; Yonekura, Kazuhiko;
Morita, Fumio; Hayashi, Taiji
P23-10
Histopathological findings, telomerase activity and oxidative stress in kidney tissue after
long-term rabbits exposure to turinabol and methanabol
Fragkiadaki Persefoni, Tsitsimpikou Christina, Vasilaki Fotini, Stivaktakis Polychronis, Segradakis John,
Tsarouhas Konstantinos, Tzardi Maria, Kouretas Demetrios, Tsatsakis Aristidis
P23-11
Lactoferrin enhances apoptosis and protects the liver in the rat thioacetamide-induced
­liver fibrosis
Hegazy, Rehab; Hessin, Alyaa; Hassan, Azza; Yassin, Nemat; Kenawy, Sanaa
P23-12
Neuroprotective effects of tomato seed extract against rotenone-induced oxidative
­impairments and neurotoxicity in mice
Gokul K and Muralidhara
P23-13
Neurotoxicity in vitro: assessment of the predictivity of neuronal networks coped to
­microelectrode arrays for identification of neurotoxicants
P23-14
Pharmacological concentrations of mitoxantrone are able to transiently activate caspases
and dually modify glutathione pathways in HL-1 cells
Vera Marisa Costa, João Paulo Capela, Maria de Lourdes Bastos, José Alberto Duarte, Fernando
Remião and Félix Carvalho
P23-15
Protective effects of sulforaphane on acetaminophen-induced hepatotoxicity in mice
Masubuchi, Yasuhiro; Shiiki, Ayano; Matsumura, Astushi; Makita, Masahiro
P23-16
TCDD-induced sebaceous gland atrophy in mice: Kinetics of restoration following end of
treatment
Fabienne Fontao, Frédérique Ino, Olivier Sorg, Jean-Hilaire Saurat
115
Posters
Tzutzuy Ramirez, Timo Weisschu, Hans-Albrecht Hüner, Bennard van Ravenzwaay, Robert Landsiedel
P23-17
Study of Benzophenone Induced Oxidative Stress in the Cytomorphological Alterations
of Rat Lung
Uma Dutta
P24: Toxicology of Nanomaterials
P24-01
Acute and subchronic pulmonary toxicity of cerium oxide nanoparticles for safety
­assessment
Alazne Domínguez, Carolina Aristimuño, Eneritz Arriaga, Amaia Aspiazu, Blanca Suárez-Merino and
­Felipe Goñi-de-Cerio
P24-02
Amorphous Silica Nanoparticles Induce Autophagic Cell Death in HepG2 Cells Triggered by
Reactive Oxygen Species
Yongbo Yu, Junchao Duan, Yang Yu, Yang Li, Xiaomei Liu, Xianqing Zhou, Peili Huang, Zhiwei Sun
P24-03
Assessment of oxidative stress and cytotoxicity of copper oxide nanoparticles in human
skin epidermal cell line (HaCaT)
Saud Alarifi, Daoud Ali
P24-04
Biodistribution and toxicological effects of intranasally instilled polyamidoamine (PAMAM)
dendrimers in BALB/c mouse brain
Tin-Tin Win-Shwe, Yoshika Kurokawa, Hiroshi Nitta, Seishiro Hirano, Hideko Sone
P24-05
Comparative Immunotoxicity on Physicochemical Properties of Single-Walled Carbon
Nanotubes: in Vitro and in Vivo
Soyoung Lee, Dongwoo Khang, Sang-Hyun Kim
P24-06
Ecotoxicity of engineered nanomaterials: known facts and data gaps
Juganson, Katre; Ivask, Angela; Koitjärv, Meelika; Mortimer, Monika; Bondarenko, Olesja; Kasemets,
Kaja; Kahru, Anne
P24-07
Effect of manufactured nanoparticles on allergen-induced sensitization
Birgit Baré, Nathalie Lambrechts, Hilda Witters, Peter Hoet, Inge Nelissen
P24-08
Effects of zinc oxide nanoparticles on an in vitro model of the air-blood barrier
R. Bengalli, M. Gualtieri, M. Camatini, C. Urani, P. Mantecca
P24-09
High-temperature calcined fullerene nanowhiskers and multi-wall carbon nanotubes have
abilities to induce IL-1beta secretion through NLRP3-dependent mechanism, depending on
their lengths
Nishimaki-Mogami, Tomoko; Cui, Hongyan; Wu, Weija; Okuhira, Keiichiro; Naito, Mikihiko; Nishimura,
Tetsuji; Sakamoto, Yoshimitsu; Ogata, Akio; Maeno, Tomokazu; Inomata, Akiko; Nakae, Dai; Miyazawa,
Kun’ichi; Hirose, Akihiko
116
P24-10
In vitro exposure of human intestinal cells to iron phosphate nanoparticles indicate no
­direct cytotoxicity
von Moos, Lea; Trantakis, Ioannis; Rast, Peter; Hilty-Vancura, Florentine; Zimmermann, Michael;
Pratsinis, Sotiris; Sturla, Shana
P24-11
Influence of nano-polystyrene particles in inducing cytotoxicity in mice co-injected with
carbon tetrachloride, cisplatin, or paraquat
Isoda, Katsuhiro; Yoshimi, Shimizu; Nishimura, Tetsuji; Tezuka, Masakatsu; Ishida, Isao
P24-12
Long-term biodistribution, metabolism and toxicity of carbon nanotubes in vivo
Deng, Xiaoyong; Luo, Man; Shao, Erlei; Zhao, Hui; Yang, Xing; Ni, Qingshun; Jiao, Zheng
P24-13
Metabolic response of human keratinocytes to silver nanoparticles: a metabolomics study
Joana Carrola, Ana M. Gil, Ana L. D. Silva, Verónica Bastos, Helena Oliveira, José M. P. F. Oliveira,
Conceição Santos and Iola F. Duarte
P24-14
Metal nanoparticles caused death of metastatic MDA-MB-231 breast cancer cells
Adeyemi, Oluyomi; Edkins, Adrienne; Whiteley, Christopher
P24-15
Neurotoxicity Assessment of Zinc Oxide Nanoparticles: Cytotoxic and Genotoxic Effects
Gözde Kiliç, Carla Costa, João Paulo Teixeira, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
P24-16
Particle and Fiber toxicity database – PaFtox
Schröder K., Pohlenz-Michel C., Voss J.-U., Simetska N., Escher S., Mangelsdorf I.
P24-17
Plasma Kinetics and Biodistribution of CdTe Quantum Dots in Mice:
A Comparison between Cadmium and Tellurium
Peili Huang, Jialing Zhang, Xiaoyan Du, Dong Chang, Zhiwei Sun,Ying Han, Na Liu, Hui Wang
Cavallo, Delia; Ursini, Cinzia L.; Fresegna, Anna Maria; Ciervo, Aureliano; Maiello, Raffaele; Tassone,
Paola; Iavicoli, Sergio
P24-19
The effect of silver nanoparticles in intestinal Caco-2 cells
Böhmert, Linda; Horzowski, Sabine; Lichtenstein, Dajana; Girod, Matthias; Hansen, Ulf; Niemann,
Birgit; Thünemann, Andreas; Lampen, Alfonso
P24-20
The Th2-biased immune adjuvant effect of silver nanoparticles
Yingying Xu, Huan Tang, Jia-hui Liu, Yuanfang Liu, HaifangWang
P24-21
The ToxTracker assay provides mechanistic insight into the (geno)toxic properties of metal
oxide nanoparticles.
Giel Hendriks, Anda Gliga, Harry Vrieling and Hanna Karlsson
117
Posters
P24-18
Study of cyto-genotoxic effects and inflammatory response induced by nano-sized
­titanium dioxide particles on human bronchial cells
P24-22
Toxic effects of carbon-based nanomaterials on acetylcholynesterase: an experimental
and computational investigation
Tina Mesarič, Lokesh Baweja, Damjana Drobne, Darko Makovec, Alok Dhawan, Kristina Sepčić
P24-23
Toxicity mechanisms of coated and uncoated silver nanoparticles to yeast Saccharomyces
cerevisiae BY4741
Suppi, Sandra; Kasemets, Kaja; Kahru, Anne
P24-24
Toxicity of Nanomaterials: Availability and Suitability of Data for the Development of In
Silico Models
Richarz, Andrea-Nicole; Cronin, Mark; Madden, Judith; Lubinski, Lukasz; Mokshina, Elena; Urbaszek,
­Piotr; Puzyn, Tomasz; Kuz’min, Victor
P24-25
Toxicokinetics of zinc oxide nanoparticles in rats treated by two different routes, by a
­single intravenous injection and a single oral administration
Kwangsik Park, Jonghe Choi, Heyjin Kim, Pilje Kim, Hyun-Mi Kim and Kyunghee Choi
P24-26
Transfer of Engineered Nanoparticles across the Human Placenta
Stefanie Grafmüller, Ursula von Mandach, Pius Manser, Liliane Diener, Pierre-André Diener, Wolfram
Jochum, Harald F. Krug, Peter Wick
P24-27
ZnO nanoparticles and dissolved zinc affect transcripts of pro-inflammatory cytokines in
zebrafish embryos
N. Brunab, V. Christena, B. Wehrlib, K. Fentab
P25: Other
P25-01
Aluminum hydroxide in preclinical vaccine safety testing
Harmke H. van Vugt, Ph.D., Miranda H.M. van Tuyl, M.Sc., Harry H. Emmen, M.Sc.
P25-02
Antiulcer activity of mirtazapine, escitalopram and venalfaxine on oxidant and antioxidant
parameters in stomach tissue of depressed rats
Sally A. El-Awdana, Hala F. Zaki, Sanaa A. Kenawy
P25-03
Assessment of chromium and nickel levels in maternal blood, placenta and cord blood by
Graphite Furnace Atomic Absorption Spectrometry
Arica, Enes; Kayaalti, Zeliha; Kaya Akyuzlu, Dilek; Soylemezoglu, Tulin
P25-04
Etiological and demographic characteristics of poisoning cases admitted to all departments of university hospital in Diyarbakir, Turkey.
Arica, Enes; Uysal, Cem; Tokgoz, Orhan; Goren, Suleyman
P25-05
Beneficial impact of polyphenolic compounds from Aronia melanocarpa berries on the
­biomechanical properties of the lumbar spine vertebral body in cadmium-exposed rats
Roszczenko, Alicja; Brzóska, Malgorzata M.; Rogalska, Joanna
118
P25-06
Biochemical and haematological parameters are different for rats of the same strain
­obtained from different breeders.
Schleh C, Allingham P, Rudragowda S, Ceccatelli R, Takawale P, Schropp P, Schmid S, Luetkenhaus K,
Neuenhahn P, Leoni AL
P25-07
Brine shrimp toxicity of total extracts of four cruciferous plants
Ebadollahinatanzi, Alireza; Maleki, Zohreh; Ahadi-Mikaeildarsi, Monir; Alavi, Seyed Mohammad
P25-08
Measurement of antioxidant capacities in two plant extracts from cruciferae family
Ebadollahinatanzi, Alireza; Shoara, Saghar; Farzi, Soheilla
P25-09
Chlorpyrifos neurotoxicity – a scientometric analysis
Schulze, Michaela, Schrumpf, Laura and Schulze, Johannes
P25-10
Diosmin protects against TCE (trichloroethylene) induced renal injury in Wistar rats:
Plausible role of p53, Bax and caspases
Muneeb U Rehman, Mir Tahir, Abdul Quaiyoom Khan, Rehan Khan, Abdul Lateef, Oday-O-Hamiza,
Farrah Ali and Sarwat Sultana
P25-11
Evaluation of Arsenic Levels in Biological Samples of Smelter Workers in Turkey
Bayram Yüksel, Zeliha Kayaalti, Vugar Ali Türksoy, Engin Tutkun, Tülin Söylemezoğlu
P25-12
Evaluation of the Pb, Cd, Fe, Zn and Cu levels in the blood samples of metallurgy workers
exposed to Pb and control groups
Odabasi, Miyase; Kayaalti, Zeliha; Türksoy, Vugar Ali; Yilmaz, Hinç; Söylemezoglu, Tülin
P25-13
Exposure to PM 2,5-bound PAHs in Rome: the contribution of transportation
­microenvironments
M. Gherardi, M.P. Gatto, A. Gordiani, C. Gariazzo
Posters
P25-14
Urban Air Pollution in Rome: Children and Elderly Exposure to Polycyclic Aromatic
­Hydrocarbons in Fine Particulate Matter (PM2.5)
M. Gherardi, M.P. Gatto, C. Gariazzo, A. Gordiani
P25-15
Impact of hexabromocyclododecane on lipid and glucose metabolism in high-fat diet-­
induced obese mice
Rie Yanagisawa, Tin-Tin Win-Shwe, Eiko Koike, Hirohisa Takano
P25-16
(Cancelled)
P25-17
Involvement of Heme Oxygenase-1 in attenuation of the Cardioprotective effect of
­Ischemic Preconditioning in Diabetic Rat Heart
Goyal, Shubham; Verma, Nitin; Jinddal, Vaneeta
119
P25-18
To evaluate the Protective effect of Vitis vinifera & Solanum lycopersicum in diet induced
obesity in Rats
Goyal, Shubham; Verma, Nitin; Jinddal, Vaneeta
P25-19
New medicine approach in pollution’s hospitalizations
Polichetti, Giuliano; De Sio, Alessandra
P25-20
Patterns of self-poisoning in Sikasso, Mali
Hami Hinde, Diallo Tidiane, Maïga Ababacar, Mokhtari Abdelrhani, Soulaymani-Bencheikh Rachida,
Soulaymani Abdelmajid
P25-21
Poisoning of domestic animals: 2012 data from Poison Control Centre of Milan
Francesca Caloni, Cristina Cortinovis, Fabiola Pizzo, Marina Rivolta, Franca Davanzo
P25-22
Preclinical Toxicology of Mesima, an Anti-cancer Immunological Activator; Results of Oral
Subchronic Toxicity in Rats
Jung-Ho Noh, Jae-Woo Cho, Eun Ju Jeong, Kyoung-Sik Moon
P25-23
Respiratory consequences of treatments developed to counteract severe soman-induced
refractory status epilepticus in mice
Sébastien Graziani, Didier Christin, Philippe Desforges, Gilles Guillot, Noel Perrier, Annie Foquin,
­Frederic Dorandeu et Laurent Taysse.
P25-24
Subacute toxicity study of CKD-501, a novel thiazolidinedione, after 4-week repeated oral
administration in mice
Kyoung-Sik Moon, Jung-Ho Noh, Yong-Bum Kim, Eun Ju Jeong, In-Chang Hwang, Dal-Hyun Kim,
­Ho-Sung Yu, Hyo-In Yun
P25-25
The Apoptotic Effect and Mechanism of Arsenic Compounds in MA-10 Mouse Leydig
­Tumor Cells
Huang, Bu-Miin
P25-26
The Maternal-Infant Research on Environmental Chemicals Study – Overview of the
­Biomonitoring Component of a Canadian Pregnancy Cohort
D’Amour M, Arbuckle TE, Fisher M, and Fraser W.
P25-27
Toxicology Evaluation of Impurities during Small Molecule Drug Development
Elizabeth Martin, Charles Humfrey and Andrew Teasdale
P25-28
Forensic toxicological Cases in the Pharmacology Curriculum in Undergraduated 3rd year
Medical Students
Pavlina Gateva, MD, PhD
120
Club Casino
P19: Reproductive Toxicology
P19-01
Bidirectional placental transfer of BPA and its metabolite in the perfused human placental
cotyledon model
Corbel T, Gayrard V, Berrebi A, Gil S, Lacroix M, Puel S, Viguié C, Toutain PL, Picard-Hagen N
P19-02
Effect of Zearalenone gestational exposure: modulation of placenta cell differentiation
and transport function
Caroline Prouillac, Farah Koraichi, Bernadette Videmann, Michelle Mazallon, Frédéric Rodriguez,
­Michel Baltas, Mohamed Benahmed, Sylvaine Lecoeur
P19-03
High-throughput compatible EST assay
Simon Stroebel, Jan Lichtenberg, Wolfgang Moritz and Jens M. Kelm
P19-04
Human exposure to chlorinated and brominated compounds is associated with increased
risk for subfertility.
Elly Den Hond, Willy Baeyens, Bianca Cox, Petra De Sutter, Tim Nawrot, Willem Ombelet, Herman
Tournaye, Nik Van Larebeke, Thomas D’Hooghe
P19-05
No longitudinal transmission of AAV5-PBGD vector DNA in mice.
Ana Gloria Gil Royo, Gloria González-Aseguinolaza, Ismael Aizpun, Astrid Pañeda Rodríguez, María
­Eugenia Cornet, María del Mar Municio, Tracy Freeman, Harald Petry, Marc Sonnemans, Lisa Spronck,
Florence Salmon
P19-06
Premature reproductive aging in female rats after developmental exposure to mixtures of
endocrine disrupters
Jacobsen, PR., Axelstad, M., Christiansen, S., Boberg, J., Hass U.
P19-07
Role of Alcohol-Mediated Rat Testes CYP2E1 Induction in Changes of Spermatogenesis
­Indices and Type I Collagen
Posters
Shayakhmetova, Ganna; Voronina, Alla; Bondarenko, Larysa; Kovalenko, Valentina
P19-08
Skeletal examination of Cynomolgus monkey fetuses: control morphology and
­Thalidomide-induced malformations
Foulon, Olivier; Spezia, François; Dauzat, Caroline; Da Silva, Marie; Barrow, Paul; Palate, Bernard;
­Forster, Roy
P19-09
Subchronic Reproductive Toxicity in Prepubertal Male Rats Exposed to Food Contaminant
Acrolein
Elif Karacaoğlu, Güldeniz Selmanoğglu, Gökçen Mülayimçelik Özgün
P19-10
Teratogenic effects of mixtures of azole fungicides assessed in rodents by using in vitro
and in vivo methods.
Angelo Moretto, Francesca Di Renzo, Francesca Metruccio, Elena Menegola
121
P19-11
The reproductive toxicity of atrazine, an endocrine disruptor
Sunny O. Abarikwu, Ebenezer O. Farombi, Aditya B. Pant
P19-12
Use of rodent and human cell culture systems for the investigation of testicular toxicity
Yannick Brunner, Laura Suter, Stefan Kustermann, Nicole Clemann; Catherine M. Pastore, Paola
­Antinori, Alexandre Scherl, Thomas Weiser, Thomas Singer, Denis Hochstrasser; Serge Nef and
Luc Stoppini,
P19-13
Using Adverse Outcome Pathway Genes to Assess Developmental Toxicity of Compounds
in a Mouse Stem Cell System
Marc A.T. Teunis, Danielle Fiechter, Paulina Mika, Peter T. Theunissen, Giel Hendriks, Cyrille A.M. Krul,
Aldert H. Piersma
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061_13_BS_CM_MERCK_ImageAD_210x297_v3.indd 1
122
29.05.13 10:39
P19-14
Validation of the Yeast Estrogen and Yeast Androgen Screens for Endocrine Active
­Substances: Inter-laboratory ring trial
Ramirez, Tzutzuy; Woitkowiak, Claudia; Hüner, Hans-Albrecht; Schönlau, Christine; Hollert, Henner;
Broschk, Susanne; Zierau, Oliver; Vollmer, Günter; Jäger, Martina; Poth, Albrecht; Higley, Eric; Hecker,
Markus; van Ravenzwaay, Ben; Landsiedel, Robert
P19-15
Double staining technique for minipig fetal skeletons at gestation day 60
Pique, Céline; Marsden, Edward; Quesada, Paul; Jocteur-Monrozier, Audrey; Briffaux, Jean-Paul
P19-16
Histology of selected organs from the Göttingen Minipig fetus from days 60 (mid term)
and 110 (term) of gestation
Thuilliez, Céline; Perron Lepage, Marie-France; Marsden, Edward; Leroy, Mariline; Briffaux, Jean-Paul
P19-17
Nigella sativa oil protects against reproductive toxicity of acetamiprid insecticide in
male rats.
Mosbah, Rachid; Yousef, Mokhtar Ibrahim; Chettoum, Aziez
P19-18
Chronic Exposure to Ethephon Induces Reproductive Stress in Albino Rat
Mayurakshi Deka and Uma Dutta
P22: Safety Pharmacology
P22-01
Cellular Impedance Assay for prediction of QT Prolongation Induced by hERG and
­non-hERG Channel Modulators Using Human Stem Cell Derived Cardiomyocytes
Zhang, Xiaoyu; Abassi, Yama
P22-02
Factors Determining the Emergence of Negative Medicine Outcomes (NMOs) in
­Emergencies
P22-03
Identification of enantiospecific interactions between clinically used chiral drugs and AHR
using in vitro stable transfected luciferase reporter gene cell line AZ-AHR
Novotna A., Kamenickova A., Dvorak Z.
P22-04
Predictivity of non-clinical Repolarization Assay Data for clinical TQT Data in FDA Database
Valentin, Jean-Pierre; Koerner, John; Willard, James; Park, Eun Jung; Bi, Daoqin; Link, William;
­Fiszman, Monica; Kozeli, Devi; Skinner, Matt; Cantilena, Louis; Gintant, Gary; Wisialowski, Todd; Pettit,
Syril; Vargas, Hugo
P22-05
Telemetric data recordings in conscious, freely moving monkeys using the DSI digital
­PhysioTel system
M Niehoff, J. Sternberg, B Niggemann
123
Posters
Merino Alonso J, Rubio Armendariz C, Núñez Díaz S, Martín Conde JA, Callejón Callejón G
Established in 1978, ECETOC is Europe’s leading industry association for
developing and promoting top quality science in human and environmental
risk assessment of chemicals. Members include the main companies with
interests in the manufacture and use of chemicals, biomaterials and
pharmaceuticals, and organisations active in these fields. ECETOC is the
scientific forum where member company experts meet and co-operate with
government and academic scientists, to evaluate and assess the available
data, identify gaps in knowledge and recommend research, and publish
critical reviews on the ecotoxicology and toxicology of chemicals,
biomaterials and pharmaceuticals.
ECETOC also provides scientific representation for its member companies
through presentations at specialist meetings and by participation in the
scientific activities of international agencies, government authorities and
professional societies. A non-profit, non-commercial and non-governmental
organisation, ECETOC prides itself on the objectivity and integrity of its work
programme, the output of which is published in the form of peer-reviewed
reports and articles in peer-reviewed journals, or as specialised workshops.
Vision
ECETOC will be the partner of choice focusing and engaging industry
expertise for the European Commission, ECHA, and EFSA in the development
of practices and concepts based on science as policy becomes embodied in
regulations.
Mission
To promote the use of good science in human and environmental risk
assessment of chemicals, biomaterials and pharmaceuticals.
Approach
ECETOC pursues its vision and mission through an issue-based science
strategy comprising 10 science areas grouped under 5 main themes:
- Presence of chemicals in humans
- Presence of chemicals in the environment
- Effects in humans and ecosystems
- Methods
- Science of risk assessment
Further information is available at www.ecetoc.org
ECETOC is Europe’s leading industry association for developing and promoting top
quality science in human and environmental risk assessment of chemicals.
Av e nu e E . V an N ie u w en h u ys e 2 Bt e 8, B - 1 1 60 B ru s se l s
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E- ma il: i nf [email protected] e c e t oc .o rg
Vi s it w w w .ecet o c .o rg f o r t h e l at est n ew s f ro m EC ET O C
124
Author Index
Aardema, Marilyn
P10-10, P10-17
Aarts, Jac M.M.J.G.
P12-42
Abarikwu, Sunny
P19-11
Abassi, Yama
P12-86, P22-01
Abdel-Wahab, Doaa
P07-32
Abraham, Klaus
P14-02
Abubakar, Mu’azu Gusau
P07-07
Abusoglu, Sedat
P08-35
Acilan, Ceyda
P03-14
Achard, Sophie
P08-26, P08-45
Ada, Ahmet O.
P02-22
Adam, Jacqueline
P13-11, P20-21
Adamovsky, Ondrej
P08-12
Ademuyiwa, Olapido
P08-30
Adewole, O.
P08-30
Adeyemi, Oluyomi
P24-14
Adfeldt-Still, Oliver
P20-35
Adiguzel, Zelal
P03-14
Adriaens, Els
P11-02, P15-21,
P18-09
Afshari, Reza
S13-4
Agarkova, Irina
P12-01
Aggarwal, Manoj
P18-01
Ahadi – Mikaeildarsi, Monir
P25-07
Ahamed, Sayed
P09-19
Ahmed, Rafat S
P17-08
Ahmet, Sayal
P07-09
Aicher, Lothar
S12-2
Aisaki, Ken-ichi
P16-11
Aitken, Laura
P13-12
Aizpun, Ismael
P19-05
Ajvazi, Majlinda
P02-04
Akinwunmi, F.
P08-30
Akiyama, Takumi
P11-08
Aktas, Ayca
P10-11, P08-15
Akyüzlü, Dilek
P10-06, P10-07,
P10-08, P13-03,
P14-05, P14-14,
P14-15, P16-14
Al Sharif, Merilin
P05-23
Alarifi, Saud
P24-03
Alavi, Seyed Mohammad
P25-07
Alberto Duarte, José
P13-16
Albrecht, Achim
P15-07
Alegakis, Athanasios
P09-01, P17-18
Alemdar, Yilmaz
P02-22
Alépée, Nathalie
P18-09
Ali Youssef, Doris
P15-18
Ali, Imran
P13-08
Al-Jubory, Aliaa
P12-78
Allais, Linda
P15-26
Allen, Sandra L
S11-3
Allingham, Philip
P11-10, P15-07,
P15-16, P25-06
Almagro-Berlanga, Rafael
P10-02, P09-24
Almeida, Mara Ribeiro
P10-14
Aloise, Monia
P04-01, P04-02
Alonos-Moraga, Angeles
P10-02, P09-24
Alov, Petko
P05-05, P05-23
Alshana, Usama
P02-15
Althaus, Jorane
P12-23
Altun, Beril
P02-15
Alzualde, Ainhoa
W11-5
Amado, Francisco
P13-16
Amberg, Alexander
S09-3
Ambrosio, Massimo
W04-2, W04-3,
W04-5, P05-06
Ambroz, Antonin
P12-25
Amir, Mohd
P17-02
Anadon, Arturo
P12-37, P12-50
Andersson, Patrik
P20-35
Andrade, Vanda
P04-08
Ang, Xiaoman
P12-88
Anger, Lennart T.
P05-11
Anisimova, Svitlana
P13-10
Anjum, Sameya
P07-05, P08-29
Ankley, Gerald T.
P08-20
Ankrah, Nii-Ayi
P09-08
Ansari, Sam
P16-13
Ansoborlo, Eric
P13-06
Anthérieu, Sébastien
P08-03
Antoine, Daniel J
W10-4, W13-3
Antonijevic, Biljana
P20-13, P20-14
Antonijevic, Evica
P20-14
Antunes, Alexandra MM
P14-01
Antunes, Lusania Maria Greggi P10-14
Anzenbacher, Pavel
P06-03, P09-02,
P14-19
Anzenbacherova, Eva
P06-03, P09-02,
P14-19
Aouichri, Mohamed
P07-31
Arand, MichaelW08-1, P13-09,
P14-13, P20-25
Araujo, Gabrielle
P20-37
Arbo Dutra, Marcelo
P12-62, P13-16
Arbuckle, Tye
P25-26
Ares, Irma
P12-37, P12-50
Ariano, Eugenio
W02-3
Arica, Enes
P25-03, P25-04
Arisseto, Adriana
P09-18
Aristimuño, Carol
P24-01
Arlt, Volker M
S05-1
Armento, Alexander
P07-03, P07-25,
P12-34
Armer, Lynn
P15-01
Arogundade, L.
P08-30
Arora, Manu
P07-22
Arriaga, Eneritz
P24-01
Arvidson, Kirk
P05-06
Asare, George
P09-08
Aschner, Michael
P04-08
Posters
A
125
Asik, Elif
P02-15
Aspiazu, Amaia
P24-01
Assanome, Karen
P08-52, P15-29
Atabey, Esref
P02-15
Ataman, O. Yavuz
P02-15
Atli, Gülüzar
P08-01, P08-02
Atobatele, Z.
P08-30
Attianese, Carolina
P08-05
Aucejo, Susana
P09-03, P09-04,
P09-05, P09-06,
P09-07
Aufderheide, Michaela
P12-09, P12-66
Augsburger, Anne-Sandrine
P23-07
Autrup, Herman
S15-1
Axelstad, Marta
P17-09, P19-06
Ayala, Jose
P09-18
Aydin, Emine Gul
P08-35
Aydin, Sevtap
P10-01, P10-15,
P10-16, P12-19
Ayehunie, Seyoum
P07-03, P12-03
Aytaç, Zeki
P10-16
Azevedo, Keller
P06-02
B
Bacaksiz, Aysegul
P08-35, P16-14
Bacanli, Merve
P10-01, P10-15,
P12-19
Bacanu, Claudia
P02-19
Bacci, Michela
P15-18
Bachelor, Michael
P12-36
Badea, Alexandra
W15-1
Bae, Il-Hong
P12-30
Baeyens, Willy
P19-04
Bailey, Lucy
P12-84
Baillie, Thomas A
S17-2
Balalau, Dan
P20-04
Balavenkatraman, Kamal Kumar P12-61
Baldi, Isabelle
W02-5
Baldrick, Paul
W03-1
Ball, Jonathon
W11-3
Baltas, Michel
P19-02
Bandouchova, Hana
P08-12, P08-21,
P08-41
Banerjee, Basu D
P17-08
Barboro, Paola
P16-01
Barbosa, Daniel José
P14-18
Barbounis, Manolis
P17-18
Barcellini-Couget, Sylvie
P12-81
Barcelo, D
S12-1
Barcia, Rita
P12-21
Bardet, Gaëlle
P08-26, P08-45
Baré, Birgit
P24-07
Barlow, Sue
P05-06
Barnett, Brenda
P10-10
Barregard, Lars
P08-08
Barreiro, Eliezer
P20-37
Barrero-Moreno, Josefa
P08-44
Barrett, G
W04-3
Barroso, João
P18-09
126
Barrow, Paul
Bartels, Michael
Bártiková, Hana
Bartos, Milan
Bartosova, Ladislava
Basaran, A.Ahmet
Basaran, Nursen
Bassan, Arianna
Bassetti-Gaille, Catherine
Bastías Chian, María José
Bastos, Maria de Lourdes
Bastos, Verónica
Batinic-Haberle, Ines
Batke, Monika
Batoréu, M Camila
Battal, Dilek
Bauch, Caroline
Bauer, Daniel
Bauer, Mario
Baweja, Lokesh
Baykal, Tarik
Beauchamp, Philippe
Bechshøft, Thea Ø.
Bechter, Rudolf
Begriche, Karima
Behm, Claudia
Behnisch, Peter
Beker, Anna
Beklova, Miroslava
Belcastro, Vincenzo
Bell, David R
Belles, Montserrat
Beltran, Mariana
Benahmed, Mohamed
Bengalli, Rossella
Benjamin, Amanda
Benvenisty, Nissim
Beraldo, Heloisa
Bergamini, Cecila
Berger-Preiss, Edith
Bergmann, Albert
Bergstrom, Goran
Bermúdez, Jose M
Bernauer, Ulrike
Beronius, Anna
Berrada, Houda
Berrebi, Alain
Berry, Colin
Berthold, Michael
Bertomeu, Lisa
Bertschi, Bertschi
Besshi, Kazuhiko
Bessou-Touya, Sandrine
Bhardwaj, Nitin
Bi, Daoqin
Bialesova, Lucia
Bianchi, Maria Lourdes Pires
P19-08
P18-01
P06-03
P07-30
P07-30
P10-01, P10-15,
P10-16, P12-19
P10-01, P10-15,
P10-16, P12-19
P05-16
P08-24
P04-13
P12-62, P15-09,
P23-01, P23-14
P24-13
P03-05
P05-18
P04-08
P10-11, P08-15
P12-18
P07-02
P12-04
P24-22
P03-14
P12-01
P08-59
P18-07
P08-03
P12-69
P02-21
P07-33
P08-49, P08-50
P16-13
K3-1
P08-38
P13-12
S15-2, P19-02
P24-08
W10-2
S04-1
P13-05
P12-17
P12-04
R01-1
P08-08
P09-04, P09-07
P20-06
W05-1, P20-18
P09-17
P19-01
K2-1
P05-07, P05-08
P20-11
P12-61
P23-09
P18-09
P17-10
P22-04
P08-23, P08-47
P10-14
Brees, D
W13-1
Breheny, Damien
P12-82
Breier, Albert
P08-47
Bresson, Carole
P13-06
Breyfogle, Bridget
P12-59
Brezovšek, Polona
P07-28
Bricks, Thibault
P12-33
Briedé, Jacob-Jan
P12-85, P16-10
Briffaux, Jean-Paul
P15-26, P19-15,
P19-16
Broadmeadow, Alan
P18-14, P18-26
Broeckaert, Fabrice
P18-23
Broekman, Henrike
P09-09
Broschk, Susanne
P19-14
Brott, David
W10-2
Brouwer, Adam
P02-21
Brozzi, Rosella
P20-12
Brtko, Julius
P08-23, P08-47
Brun, Nadja
P24-27
Bruning, David
P10-17
Brüschweiler, Beat J
W17-5
Brzóska, Malgorzata M.
P13-19, P13-25,
P14-23, P25-05
Buenter, Antonia
P20-21, P11-03
Buetler, Timo
P09-13
Buha, Aleksandra
P08-09, P08-22,
P20-13, P20-14
Bulat, Petar
P08-09
Bulat, Zorica
P08-09, P08-22,
P20-13
Burgaz, Sema
P02-15, P02-22
Burkina, Viktoriia
P01-05, P12-76
Burton, Julien
P18-04
Buscaglia, Eleonora
P04-01, P04-03
Bushell, Martin
W13-4
Buss, Nicholas
W09-5
Bystrzejewski, Michal
P07-20, P12-16
C
Cadore, Solange
P09-11
Calabrese, Evan
W15-1
Calahorro-Nunez, Fernando
P10-02, P09-24
Calleja, Ana
P08-19, P08-18
Calléja, Fabienne
P10-03
Callejón, Gador
P22-02
Calo’, Rossella
P12-87
Caloni, Francesca
P12-39, P12-41,
P25-21
Camatini, Marina
P24-08
Cameán, Ana M.
P08-16, P08-19,
P08-17, P08-18,
P09-03, P09-04,
P09-06, P09-07
Canli, Mustafa
P08-01
Cantilena, Louis
P22-04
Canut, Lourdes
P11-14
Capela, João Paulo
P23-01, P23-14
Capone, Domenico
P08-05, P08-06
Capra, Pierluigi
P02-21
Posters
Bielec, Beata
P04-11
Bilir, Nazmi
P02-15
Billington, Richard
P18-01, P18-02
Birkner, Ewa
P04-11, P08-53
Bishop, Emma
P12-82
Bitsch, Annette
P05-18
Bjerregaard-Olesen, Christian
P15-13
Blaauboer, Bas J
S03-1
Blanco, Alfonso
P09-06
Blom, Judith
P08-57, P15-15
Blom, WM
P09-23
Blömeke, Brunhilde
P06-04, P11-07,
P15-02
Blust, Ronny
P08-20
Blüthgen, Nils
P13-14
Boberg, Julie
P08-24, P17-09,
P19-06
Boccard, Julien
P02-12
Boehm, Nils
P02-13
Boerleider, Romy Z.
P05-03
Boess, Franziska
P12-35, P13-04
Bogh, Katrine L
W12-4
Bogiel, Monika
P18-22
Bogun, Larisa
P07-14
Bohacova, Viera
P08-47
Böhmert, Linda
P24-19
Bois, Frederic Y.
S03-1, S03-4, P05-15
Boitier, Eric
W13-5, P02-16
Bolognani, F
W10-3
Bondarenko, Larysa
P13-10, P19-07
Bondarenko, Olesja
P08-07, P24-06
Bonefeld-Jørgensen, Eva C.
P03-02, P08-59,
P12-28, P12-60,
P15-13, P17-05
Bonifacio, Annalisa
P12-13
Bonner, James C
S02-1
Boobis, Alan R
S07-1, W04-2, W04-4, P05-06
Bopst, Martin
W03-4
Bordag, Natalie
P16-05
Boren, Jan
P08-08
Borgne-Sanchez, Annie
P12-64
Borowicz, Piotr
P18-22
Bortoli, Stella
P08-33
Bosak, Marek
P02-24
Bossard, Camille
P20-11
Bossi, Rossana
P15-13, P17-09
Bostanci, Omur
P07-29
Bouchard, Johanne
P07-21
Bousová, Iva
P06-03
Bouwmeester, Tewis
S04-2
Bovee, Toine F.H.
P12-42
Boyer, Scott
P05-02
Bozzetta, Elena
P02-05, P02-21
Braam, Stefan R
S04-4
Braeuning, Albert
W10-3, P13-14
Braga, Antonio L.
P13-22
Brauers, Karen
P10-20, P12-85
Braver, Michiel
P12-02
Brecht, Karin
P12-13
127
Capri, E
S12-1
Cardoso, Carolia
P20-37
Carmo, Helena
P12-62, P14-18
Carmona, Asuncion
P13-06
Carney, Edward
P18-02
Carpi, Donatella
P16-01
Carrara, Maria
P08-14
Carrola, Joana
P24-13
Caru’, Francesco
P15-18
Carvalho, Cristina
P08-37, P13-13
Carvalho, Félix
P02-17, P12-49,
P13-01, P14-18,
P15-10, P15-11,
P23-01, P23-14
Carvalho, Márcia
P15-09
Cassali, Geovanni
P13-05
Castellano, Victor
P12-37, P12-50
Castro, Matilde
P03-05, P07-15,
P09-15, P12-21,
P12-22, P14-01
Catoire, Sophie
P12-74, P20-03
Caumette, Vincent
P08-10
Cavallo, Delia
P02-02, P24-18
Cavill, Rachel
P12-85
Ceccatelli, Raffaella
P25-06
Ceccatelli, Sandra
K5-1
Cechelli, Romeo
S03-1
Cecilie Bonefeld Jørgensen, Eva P17-09
Celebi, Celalettin R.
P02-15
Ceriani, Roberta
P09-18
Cervinkova, Zuzana
P07-04
Cesla, Petr
P07-04
Cetin, Yuksel
P03-14
Cha, Ji Young
P20-15
Chakravarti, Suman
P05-01
Chang, Louis W
P08-55
Chanotng, Boonrat
P13-07
Chantong, Boonrat
P12-83
Chapman, Kathryn
W06-4
Charmeau, Carole
P18-19
Charvet, Igor
P12-26
Chashchyn, Mykola
P13-18
Chassaigne, Hubert
P16-01, P16-02
Chaudhry, Qasim Ali
P14-26
Chaves, Miriam
P12-08
Checheva, Maria
P05-06
Chen, Chunying
S02-2
Chen, Rong-Jane
P08-55
Chen, Tao
W13-5, P02-16
Cheng, Shu-Yuan
P17-16
Cheng, Yi
P23-08
Chettoum, Aziez
P01-06, P19-17
Chevillotte, Grégoire
P20-28
Chiara, Francesca
P04-01, P04-02
Chibout, Salah-Dine
W10-3, W13-1, P12-13, P12-20, P12-61,
P13-21
Child, Matthew
P12-03
Chlopecka, Magdalena
P12-77, P17-15
Cho, Eun-Sang
P01-01
128
Cho, Il Je
P12-46, P12-49,
P12-73
Cho, Jun-Cheol
P12-30
Cho, Sun-A
P12-30
Cho, Su-Yeon
P14-06, P14-07,P14-08
Choi, Byungho
P02-18, P04-09
Choi, Eun-young
P08-27
Choi, Jonghe
P24-25
Choi, Kyunghee
P24-25
Choi, Yeoul
P15-27
Chorti, Maria
P06-01
Chouriyagune, Charoen
P04-07
Christakis-Hampsas, Maria
P14-17, P17-07
Christen, Verena
P24-27
Christiane, Beckmann
P10-19
Christiansen, Sofie
P08-24, P19-06
Christin, Didier
P25-23
Chung, Chieh-Han
P03-01
Chunhabundit, Rodjana
P03-12
Ciervo, Aureliano
P02-02, P24-18
Cieszanowski, Andrzej
P07-20, P12-16
Ciffroy, P
S12-1, S12-4
Cini, Barbara
P02-21
Cipriano, Madalena
P03-05, P12-21,
P12-22
Claessen, Sandra
P12-45
Clements, Mike
P12-31
Clift, Martin
P12-29
Coatney, Robert W
W15-3
Cocher, Hervé
P25-23
Cochet, Claude
P11-16
Cocker, John
W02-4
Coelho, Patrícia
P02-08
Coenraads, Pieter Jan
P06-04
Cohen, Samuel M
S07-4
Cohen, Stephen
P23-02
Cohrs, Christopher
P11-07
Cok, Ismet
P07-24, P07-29,
P08-15
Colacci, Annamaria
P12-17
Coleman, David
P15-25
Colombo, Paolo
P15-18
Colosio, Claudio
W02-3
Colter, David
P12-10
Comley, R
W15-2
Commandeur, Jan
P12-02
Connon, Richard E
W18-2
Conolly, Rory B
S07-4, K6-1
Contal, Servane
P15-02
Coonen, Maarten
P12-02
Corbel, Tanguy
P19-01
Cordier, Andre
W13-1, P13-21
Cornet, Maria Eugenia
P01-03, P19-05
Corsini, Emanuela
W01-4, P11-02
Cortes Picazo, Patricio
P04-13
Cortini, Emanuela
P04-01
Cortinovis, Cristina
P12-41, P25-21
Corton, J Christopher
S16-2
Costa, Carla
P02-08
Costa, João G.
P07-15, P09-15
D
d’Argembeau-Thornton, LaurenceP12-58
da Costa Araújo, Silvana
P23-01
da Rocha, João Batista Teixeira P13-22
Da Silva, Marie
P19-08
Daci, Nexhat
P02-04, P08-34
da Costa, Goncalo Gamboa
S05-2
Dae-Seop, Shin
P15-20
Dagher, Rafif
P03-03
Dallegrave, Eliane
P13-16
Dalzell, Abigail
P20-09, P20-10
Damdimopoulou, Pauliina
P13-08
D’Amour, Monique
P25-26
Damsten, Micaela
P18-27
Danten, Muriel
P18-19
Darin, Joana Darc Castania
P10-14
Darnell, Malin
P14-25
Darolles, Carine
P13-06
Datta, Sudip K
P17-08
Dauzat, Caroline
P19-08
Davanzo, Franca
P25-21
David, Sylvie
P15-26
Davuljigari, chand Basha
P08-04
de Bourayne, Marie
P11-16
de Graaf, Inge
P12-63
de Groot, Didima
P07-33
de Haan, Laura H.J.
P12-42
De Javel, Dominique
P20-16
de Jersey, John
P16-07
de Jong, Govardus
P09-09
de la Moureyre-Spire, Catherine W13-5, P02-16
De Luca, Jane
P12-58
De Luna-López, Ma. Carolina
P02-07
de Oliveira Silva, Diogo
P08-33
De Sio, Alessandra
P08-05, P08-06,
P25-19
De Smedt, Ann
P18-09
de Sousa, Georges
P12-81, P17-04
De Sutter, Petra
P19-04
De Vizcaya-Ruiz, Andrea
P08-32
de Wever, Bart
P18-09
De Witte, P
W11-4
Dear, James
W13-3
Dearman, Rebecca
P11-12, P11-13
Decrock, Elke
W07-2
Deferme, Lize
P16-10
Degen, Gisela H.
P12-69
Degim, Ismail Tuncer
P07-24
Dejong, Cees
P12-45
Deka, Mayurakshi
P19-18
de Lange, Dylan
S13-5
del Cacho, Carmen
P08-44
Dellarco, Michael
S07-2
Del Espinola, A
W10-3
del Mar Municio, Maria
P01-03, P19-05
Demidkina, Anna
P01-02
Demirbag, Ali E.
P02-22
Demircigil, Gonca Çakmak
P02-15
Demirkol, Sait
P07-10, P07-11
Demiroglu, Canan
P02-22
den Hartog Jager, Stans
P09-09
Den Hond, Elly
P10-12, P19-04
Deng, Xiaoyong
P24-12
Denslow, Nancy D
W18-4
Dekant, Wolfgang
S03-1
Derici Eker, Ebru
P10-11
Dernick, Karen
P12-35
Desai, Pankaj
P07-17
DeSesso, John M
W14-4
Desforges, Philippe
P25-23
DeVries, Erik FJ
W15-2
DeVries, Irma
P05-03
Dey, Swatee
P20-02
Dhawan, Alok
P24-22
D’Hooghe, Thomas
P19-04
Di Renzo, Francesca
P19-10
Diallo, Tidiane
P25-20
Diaz Ochoa, Juan Guillermo
P05-17
Dickel, Denise
P11-14
Diener, Liliane
P24-26
Diener, Pierre-André
P24-26
Diepgen, Thomas
P06-04
Dierckx, RAJO
W15-2
Dietrich, Daniel
P08-40
Dietz, Audrey
P13-21
Dietz, Rune
P08-59
Dilon, Debbie
P12-82
Dincer, Zuhal
P13-21
Dinis-Oliveira, Ricardo
P13-16
Dogan, Zehra
P08-01
Posters
Costa, Solange
P02-08
Costa, Vera Marisa
P13-16, P23-01,
P23-14
Coté, Serge
W10-1
Coulouarn, Cédric
P08-03
Court Marques, Danièle
P18-23
Couttet, Philippe
W10-3, W13-2,
W13-5, P02-16,
P12-13, P12-20,
P12-61
Cox, Bianca
P19-04
Crawford, A
W11-4
Crome, Steven
P18-14, P18-26
Cronin, Annette
P13-09
Cronin, Mark T. D.
W04-2, W04-3, W16-2, P05-04, P05-05,
P05-07, P05-06,
P05-08, P05-16,
P05-23, P24-24
Cruz, Hélder
P12-21
Cruz, Pedro
P12-21
Cudd, Margaret Amelia
P18-07
Cui, Hongyan
P24-09
Curcic, Marijana
P20-14
Currie, Richard A
S07-3, S16-1
Cuzic, Snjezana
P07-18
Cywinska, Monika
P07-20, P12-16
Czich, Andreas
S01-4
129
Dollenmeier, Peter P20-25
Domingo, Jose-Luis
P08-38
Domínguez, Alazne
P24-01
Dorandeu, Frederic
P25-23
Dorne, Jean-Lou
W18-5
Dörig, Dario
P20-21, P11-03
Dos Santos, Tania
P12-83
Dotse, Eunice
P09-08
Dougnon, Victorien
P09-21, P21-02
Drobne, Damjana
P24-22
Drzewiecka, Agnieszka
P15-28, P18-22
Duarte, Iola
P24-13
Duarte, José
P23-14
Dubost, V
W10-3, W13-1
Ðukic-Cosic, Danijela
P08-09, P08-22,
P20-13
Dulize, Remi
P12-75
Dumanovic, Jelena
P20-14
Dutta, Uma
P19-18, P23-17
Duydu, Yalçin
P12-69
Dvorak, Zdenek
P07-08, P09-02,
P22-03, P18-24
Dybdahl, Marianne
P12-15
Dziekan, Natalia
P12-77, P17-15
E
Ebadollahinatanzi, Alireza
P25-07, P25-08
Eberlin, Marcos Nogueira
P15-30
Ebert, Ralf-Uwe
P20-38
Edkins, Adrienne
P24-14
Edmiston, Jeffery
P02-25
Edtbauer, Michael
P05-19
Edwards, J
W04-5
Efe, Sibel
P02-22
Egea Gonzalez, Francisco Javier W02-2
Ehlers, Anke
P14-27
Ehrenshaft, Marilyn
P08-13
Eichinger-Chapelon, Anne
P18-16
El ALi, Zeina
P12-80, P11-01,
P11-16
El Awdan, Sally
P25-02
Elbekai, Reem
P18-12, P18-13,
P18-11
Eleršek, Tina
P07-28
Elford, Peter
P07-21
El-Haggar, Mohamed
P07-32
Ellinger-Ziegelbauer, Heidrun
W13-5, P02-16
Ellis, G.
87
Ellis, Samantha
P12-18, P12-75
Ellis-Hutchings, Robert
P18-02
Eltze, Tobias
P11-02
Ema, Makoto
P18-10
Emer Gegin, Eda
P07-09, P07-11
Emerce, Esra
P07-24, P07-29
Emiliano, Nathalia
P20-37
Endes, Carola
P12-29
Engeli, Roger
P08-54, P15-08
Enoch, Steven
P05-04, P05-05,
P05-08
130
Enomoto, Hatsune
Ercin, Nuri
Erdil, Ahmet
Erdmann, Simon E.
Eroglu, Ali
Errington, Graham
Ertas, Nusret
Escher, Sylvia
Esguerra, C
Eskes, Chantra
Espana, Bernadette
Esselen, Melanie
Esser, Philipp R.
Ewart, Lorna
Expert Committee, ANSES’
Working Group on EDs
Expert Workin Group on
Endocrine Disruptors, ANSES
P16-06
P04-12
P04-12
P08-59
P08-01
P10-13
P02-15
P20-38, P24-16
W11-4
P18-09
P19-02
P10-22
P11-01
S14-5
616
451
F
Faass, Oliver
P08-24
Fabbri, Marco
P12-52
Fabian, Eric
S16-4, P15-14
Fabriek, Babs
P11-04
Fabrizi, Giovanni
P02-23
Fagerberg, Bjorn
P08-08
Fahrer, Jörg
P03-07
Faltermann, Susanne
P15-15
Fang, Min
P16-09
Fant, Pierluigi
P15-26
Faqi, Ali
P09-22
Farahmand, Sara
P20-02
Fariss, Marc
P02-25
Farzi, Soheilla
P25-08
Fashe, Muluneh
P14-24
Faust, Michael
S12-1, S12-4
Fautz, Rolf
P06-04
Federova, Ganna
P01-05
Feher, Domonkos
P11-09
Felenda, Jennifer
P10-19
Felice Guidugli,
Ruggero Bernardo
P15-30
Felter, Susan
W04-2, W04-5, P05-06,
P20-29
Fent, Karl
P15-15, P24-27
Fernandes, Ana S.
P03-05, P07-15, P09-15
P12-22, P21-03
Fernandes, Eduarda
P23-01
Fernandes, Isabela C.
P09-10
Fernandes, Raquel MT
P15-30
Fernandez, Elena
P11-14
Ferrara, Donato
P23-04
Ferreira, Rita
P13-16
Ferrer, Emilia
P09-16
Ferret, Pierre-Jacques
W04-5, P20-16
Feuerstacke, Christian
P04-10
Fey, Stephen
P12-51
Ficheux, Anne-Sophie
P20-28
Ficheux, Hervé
P12-74, P20-03
Furlong, Stephen
Fussel Karma C
W10-2
S15-2
G
Gad, Seham
P07-32
Gademann, Karl
P08-57, P15-15
Gaj, Stan
P10-20
Gajewska, Monika
P05-12, P05-13
Galassi, Carolina
P13-05
Galazyn-Sidorczuk, Malgorzata P13-25, P14-23
Galbiati, Valentina
P11-02
Galonnier, Maude
P20-16
Garcia, L
W04-5
Garcia-Canton, Carolina
P10-13
Garcia-Reyero, Natalia
W18-4
Gariazzo, Claudio
P25-13, P25-14
Gashaw, Hime
P12-84
Gaspari, Marco
P09-09
Gateva, Pavlina
P25-28
Gatto, Maria Pia
P20-07, P25-13,
P25-14
Gautier, Céline
P13-06
Gayrard, Véronique
P19-01
Gebel, Stephan
P16-13
Gehr, Peter
P12-29
Geier, Johannes
P18-21
Genter, Mary Beth
P07-17
Gentile, Antonio
P08-05, P08-06
Gentinetta, Thomas
P11-03
Gerbeix, Cédric
P11-01
Gerberick, G Frank
P06-04
Gerecht, Marik
P08-42
Gerhardy, Cécilia
P15-26
Germano, Davide
P12-20
Geuns, Ed
P18-27
Ghanem, Abdel-Aziz
P07-32
Gherardi, Monica
P02-02, P20-07,
P25-13, P25-14
Ghisari, Mandana
P12-28, P17-05
Ghosh, Kallol K
P12-32, P12-48
Giampreti, Andrea
P04-01, P04-03,
P04-02
Gian Christian, Winkler
P18-07
Giannakoudakis, Konstantinos P17-13
Gibbs, Susan
P11-02
Gil Royo, Ana Gloria
P19-05
Gil, Ana M.
P24-13
Gil, Fernando
P02-10, P02-11,
P08-16, P08-19,
P08-18, P20-31
Gil, Sophie
P19-01
Gili, Marilena
P02-21
Gintant, Gary
P22-04
Gioria, Sabrina
P16-01, P16-02
Girod, Matthias
P24-19
Gitrowski, Constantinos
P12-78
Giynas, Nilgun
P08-35
Glass, C Richard
S12-1, W02-2, P20-09, P20-10
131
Posters
Fickova, Maria
P08-23, P08-25,
P08-46, P08-47
Fiechter, Danielle
P19-13
Fiévez-Fournier, Laëtitia
P18-19
Fijalek, Zbigniew
P07-20
Filhol, Odile
P11-16
Filipe, Elysse
P09-15, P12-21
Filipe, Mariana
P12-21
Filipic, Metka
P07-28
Filipovic, Angelina
P20-14
Finkelstein, Martin
P18-27
Fioravanzo, Elena
P05-07, P05-06,
P05-16, P05-23
Fioretti, Marzia
P02-23
Fischmann, Stephanie
P02-13
Fiszman, Monica
P22-04
Flachi, Daniela
P04-02
Fleury, Marie-José
P12-33
Flint, Nicholas
P13-04
Flórido, Ana
P03-05
Flouris, Andreas
P06-01, P14-17
Fluri, David
P12-70
Folkertsma, Simon
P07-33, P11-04
Föllmann, Wolfram
P12-69
Fonseca, Vitor
P12-14
Font, Guillermina
P09-16, P09-17
Fontana, Stefano
P13-11
Fontanellas, Antonio
P01-03
Fontao, Fabienne
P23-16
Foquin, Annie
P25-23
Forgiarini, Alessia
P08-14
Forsblad, Andréas N. P.
P12-43
Forster, Roy
P03-03, P07-21,
P15-01, P19-08,
P23-07
Foulon, Olivier
P19-08
Fowler, Stephen
P23-02
Fragkiadaki, Persefoni
P17-07, P17-12,
P23-10
Fragoso Rocha, Bianca
P12-14
Fragoso, Meire
P06-02
Franca, Flavia
P12-08
Frandsen, Henrik
P21-01
Franken, Carmen
P10-12
Frantz, Christopher
P18-27
Fraser, William
P25-26
Frauenstein, Katrin
P07-08
Freeman, Elaine
P18-20
Freeman, Tracy
P19-05
Frericks, Markus
S15-2
Fresegna, Anna Maria
P02-02, P24-18
Frías Tejera, Inmaculada
P04-14
Frih, Hacene
P01-06
Frisch, Janina
P03-07
Froeglicher, Mirjam P20-25
Fromenty, Bernard
P08-03
Frost, Kerry
P12-18
Fuchs, Anne
P06-04
Fuerstenberger, Cornelia
P08-54, P15-08
Fujitani, Tomoko
S02-5
Gliga, Anda
P24-21
Glojnaric, Ines
P07-18
Goebel, Carsten
P06-04
Gokul, K
P23-12
Goldring, Chris
W13-1, W13-3
Golovko, Oksana
P12-76
Gomez-Berrada, Marie-Pierre
P20-16
Gomez-Limia, Lucia
P08-31
Goñi-de-Cerio, Felipe
P24-01
Gonzalez Suarez, Ignacio
P12-75
González-Aseguinolaza, Gloria P01-03, P19-05
González-Delgado,
Francisco Javier
P04-14
Gonzalez-Lopez, Eugene
P17-16
Gonzalo, Sergio
P08-38
Goodman, J
W10-3
Goonesinghe, Alex
W11-3
Gordiani, Andrea
P20-07, P25-13,
P25-14
Goren, Suleyman
P25-04
Gorniak, Silvana
P15-17
Gottipolu, Rajarami Reddy
P08-04
Gould, Sarah
P18-27
Goumenou, Marina
P13-15, P17-18
Govarts, Eva
P10-12
Goyal, Shubham
P25-17, P25-18
Grabic, Roman
P01-05, P12-76
Grabicova, Katerina
P01-05, P12-76
Gradinaru, Daniela
P02-19
Graebsch, Carolin
P12-04
Graff, Candace
P02-13
Grafmüller, Stefanie
P24-26
Grant, Helen
P04-05
Graziani, Sebastien
P25-23
Grazziotin Rossato, Luciana
P13-16
Greggi Antunes, Lusania
P10-23
Grellet, Sophie
P08-45
Grenet, Olivier
W10-3, W13-1, P12-20
Greutmann, Barbara
P12-61
Gribaldo, Laura
P12-52
Grimm, Andreas
P14-03
Groeters, Sibylle
S15-2
Groh, Isabel Anna Maria
P10-22
Groneberg, David
P08-42
Groothuis, Geny
P12-63
Grosell, Martin
P08-02
Grote-Wessels, Stephanie
P12-67
Grudzinski, Ireneusz
P07-20, P12-16
Grundler, Verena
P08-57, P15-15
Gruszka, Katarzyna
P15-28, P18-22
Grzegorzak, Natalia
P04-11, P08-53
Gualtieri, Maurizio
P24-08
Guarnieri, Chiara
P15-18
Gubandru, Miriana
P02-14, P20-04
Gudelsky, Gary
P07-17
Guedes de Pinho, Paula
P15-09
Guedj, Emmanuel
P12-75
Guerra, Lucas
P06-02
Guerreiro, Patrícia S.
P07-15, P09-15
Guerrini, Angela
P12-17
132
Guetlein, Martin
Guillot, Gilles
Guillou, Claude
Guillou, Sonia
Guillouzo, Andre
Gul, Kashif
Gultekin, Melis
Gumarova, Zhannat
Gundert-Remy, Ursula
Gunduzoz, Meside
Guo, Yin
Gupta, Bhanushree
Guth, Katharina
Gutieérrez Fernández,
Ángel José
Gutiérrez-Praena, Daniel
Gutleb, Arno
Gutscher, Heinz
Gutu, Claudia Maria
Guy, RH
Guzmán-Guillén, Remedios
P05-18
P25-23
P16-02
P20-16
S03-1
P13-22
P07-10
P14-12
P05-18
P08-35
P02-25
P12-32
P15-14
P04-14
P09-03, P09-04,
P09-06, P09-07
P15-02
W08-2
P20-04
W04-3
P08-17, P09-06
H
Ha, Sangwook
P02-18
Haag, Valérie
P23-07
Haarmann-Stemmann, Thomas P07-08
Hadrup, Niels
P21-01, P17-09
Hahn, Axel
P08-58
Hahne, F
W13-1
Haider, Wolfram
P17-01, P17-03,
P17-17
Håkansson, Helen
P20-23, P20-35,
P18-15
Hall, Mary
P11-09
Halldin, Krister
P13-08, P20-35
Haltner-Ukomadu, Eleonore
P15-14
Hami, Hinde
P25-20
Hammond, Tim G
S14-3
Hamon, Jeremy
P05-15
Han, Xianglu
S15-3
Hananias, Karime
P04-13
Hanberg, Annika
P20-18, P20-23
Handy, Richard
P12-78
Hanke, Michael
P14-26
Hansel, Trevor
P12-84
Hansen, Ulf
P24-19
Hardisson, Arturo
P04-14
Harjivan, Shrika G
P14-01
Harris, Georgina
P12-54
Hartmann, Andreas
S01-2 W06-2
Hartung, Thomas
P12-54
Hartwig, Andrea
W08-4
Hasegawa, Tatsuya
P25-16
Hass, Ulla
R01-2, P08-24, P19-06
Hassan, Azza
P23-11
Hassan, Waseem
P13-22
Hasselgren, Catrin
P05-02
Hatano, Akiko
P10-09
Hirose, Akihiko
S02-5, P11-15, P18-10, P24-09
Hirsch-Ernst, Karen Ildico
P17-03, P17-17
Hisarli, N. Deniz
P02-15
Hitotsumachi, Hiroko
P23-09
Ho, Chi-Tang
P03-01
Ho, Yuan-Soon
P03-08, P08-55
Hochstrasser, Denis
P02-12
Hodges, Nikolas
P12-11
Höehr, Nelci Fenalti
P15-30
Hoekstra, Eddo
P09-12
Hoeng, Julia
P12-75, P16-13
Hoet, Peter
P24-07
Hoffmann, Lucien
P15-02
Hoffmann, Sebastian
P12-66, P18-09
Hoflack, Jean-Christophe
P13-04
Hofman-Hüther, Hana
P10-21
Hogberg, Helena
P12-54
Hoheisel, Jörg D
W13-2
Holland, Daniela
P10-10
Hollert, Henner
P19-14
Hollnagel, Heli M
S15-4, W04-2, W04-5, P05-06
Honegger, Paul
S03-1
Hong, Chung-Oui
P07-06
Hong, Soon-Sung
P17-06
Honma, Masamitsu
P10-09
Hood, Steven
W09-3
Hooyberghs, Jef
P12-57
Hopfer, Ulrike
P12-61
Hoppensack, Anke
P12-10
Höppner, Christoph
P15-22
Horinouchi, Yuya
P08-13
Horzowski, Sabine
P24-19
Hosoi, Toru
P13-24
Hosokawa, Masahito
P15-06
Houben, Geert F
W12-3, P09-09, P09-23
Houchi, Hitoshi
P08-13
Hourihane, Jonathan OB
W12-1
Houtman, Judith
P09-05
Hristozov, Dimitar
P05-06
Huang, Bu-Miin
P25-25
Huang, Peili
P24-17
Huber, Christian
S03-1
Huener, Hans-Albrecht
P19-14, P23-13
Huettig, Nicole
P12-04
Hughes, Kathy
P18-28
Humfrey, Charles
P25-27
Hunakova, Luba
P08-47
Hunault, Claudine
P05-03
Hunter, Amy
P12-58
Husain, Asif
P07-05
Huuskonen, Hannele
P18-23
Hwang, In-Chang
P25-24
Hysek, Cédric M.
P04-06
I
Iavicoli, Sergio
Ibrahim, Mohamed
P02-02, P24-18
P12-68
133
Posters
Hattersley, Sue
W12-2
Hauaji Zacarias, Cyro
P08-52
Hauge-Nilsen, Kristin
P20-19
Hausmann, Oliver
P11-03
Häussinger, Daniel
P08-57
Havránek, Tomáš
P08-23, P08-25
Hayashi, Makoto
P05-10
Hayashi, Taiji
P23-09
Hayden, Patrick
P07-03, P07-25,
P12-03, P12-34,
P12-58, P12-59
Hayes, Mark
P11-12, P11-13
He, Min-Di
P12-53
Heal, Paul
P01-03
Healing, Guy
W03-2
Hecker, Markus
P19-14
Hegazy, Rehab
P23-11
Heine, Karin
P18-21
Heinz, Andreas
P07-32
Heise, Tanja
P17-01, P17-03,
P17-17
Helis, Agnieszka
P04-11, P08-53
Hellgren, Dennis
P20-35
Helma, Christoph
P05-18
Hemon, Patrice
P11-01
Hempel, Katja
P02-13
Hendriks, Giel
P10-03, P19-13,
P24-21
Hendriksen, Peter JM
W01-1, P11-11
Heneweer, Marjoke
S15-4
Hengstermann, Arnd
P16-13
Hengstler, Jan G.
S03-5, W08-3,
P12-62, P12-70
Hennen, Jennifer
P11-07, P15-02
Herceg, Zdenko
S10-2
Hering, Steffen
P05-19
Hernandes, Livia Cristina
P10-14
Hernández Díaz, Francisco Javier P04-14
Hernández, Antonio
P02-10, P02-11,
P20-31
Herold, M
S16-4
Herrada H., Luis
P04-13
Herrmann, Annika
P13-04
Herzyk, Danuta
P18-27
Hessel, Stefanie
P09-14, P14-04,
P14-27
Hessin, Alyaa
P23-11
Hetheridge, Malcolm
W11-3
Hewitt, Mark
P05-08
Hewitt, Philip G
S03-1, P12-56
Hibatallah, Jalila
P12-79
Higashisaka, Kazuma
P14-28
Higley, Eric
P19-14
Hillebrand, Marcus
P08-58
Hilsherova, Klara
P08-12
Hilty-Vancura, Florentine
P24-10
Hines, Ronald H
S07-4
Hirano, Seishiro
P24-04
Hirata-Koizumi, Mutsuko
P18-10
Hiromori, Youhei
P13-23
Igarashi, Katsuhide
P16-11
Iglesias, Alejandro
P08-16, P08-19,
P08-18
Iglesias, Antonio
S06-5
Ignarski, Alessa
P20-36
Ikarashi, Yoshiaki
P11-08
Ikenaga, Yutaka
P05-10
Ilie, Mihaela
P02-14, P02-19,
P20-04, P20-05
Indra, Radek
P03-10
Ingham, Philip
P23-02
Ino, Frédérique
P23-16
Inomata, Akiko
P24-09
Iscan, Mumtaz
P02-22
Ise, Ryota
P18-10
Ishida, Isao
P24-11
Ishida, Seiichi
P15-03
Isik, Sinem
P14-15
Isoda, Katsuhiro
P24-11
Isomura, Midori
P13-24
Istace, Frédérique
P20-12
Ito, Mamoru
P03-13
Ivanov, Nikolai
P12-75
Ivask, Angela
P24-06
J
Jacevic, Vesna
P20-13
Jackson, George
P07-25, P12-03,
P12-34
Jacobs, Griet
P10-12
Jacobs, Kristi
P05-06
Jacobsen Rosenskjold, Pernille P19-06
Jacobsson, Stig O. P.
P12-43
Jaeger, Martina
P19-14
Jaffe, Aron
S04-2
Jaillet, Léonore
P07-21
Jamei, Masoud
S03-1
Jamshidi, Keivan
P23-03
Jamurtas, Athanasios
P06-01, P14-17
Jang, Young-Mi
P20-20
Jankovic, Saša
P20-14
Jeanneret, Fabienne
P02-12
Jehanno, Audrey
P15-02
Jennen, Danyel
P12-02, P12-45
Jennings, Paul
S03-1, S03-2, P05-15
Jensch, Udo
P18-06
Jeon, Jin
P04-09
Jeong, Eun Ju
P25-24
Jeong, Mihye
P12-27, P17-06
Jeronimo-Roque, Daniela
P20-34
Jetten, Marlon
P12-45
Jeung, Eui-Bae
P15-27
Jiao, Zheng
P24-12
Jin, Can
P12-86
Jin, Un-ho
S18-2
Jinddal, Vaneeta
P25-17, P25-18
Jirtle, Randy L
S11-5
Jittorntrum, Bunyada
P03-12
Jochims, Karin
P20-32
134
Jochum, Wolfram
P24-26
Jocteur-Monrozier, Audrey
P19-15
Johanson, Gunnar
P20-30, P18-05
Johansson, Mia
P18-05
John, Andrea
P11-07, P14-04
Johnson, G Allan W15-1
Johnson, Reed M
W18-3
Jomaa, Barae
P12-42
Jones, David R
W03-3
Jones, Kate
W02-4
Jordá, María
P09-03, P09-05,
P09-06
Jos, Ángeles
P08-16, P08-19,
P08-18, P09-03,
09-04, P09-05, P09-06, P09-07
Joshi, Deepmala
P08-43
Jost, Martina
P15-22
Jourová, Lenka
P06-03
Juganson, Katre
P24-06
Jung, Eui-Man
P15-27
Jung, Eunsoo
P08-39
Jung, Haeng Sun
P12-06, P12-07
Jung, Kyoung Mi
P12-06
Jung, Rubi
P02-18
Junghans, Marion
S15-3
Junker, Ursula
P07-02
Jurasovic, Jasna
P08-34
Jurczuk, Maria
P14-23
Juvonen, Risto
P14-24
K
Kabakov, Alexander
P01-02
Kabatkova, Marketa
P03-09
Kacar, Omer
P03-14
Kadioglu, Ela
P02-15, P10-11
Kahru, Anne
P24-06, P24-23
Kaina, Bernd
P03-07
Kalantari, Fereshteh
P20-30
Kalberlah, Fritz
P18-21
Kalra, Om P
P17-08
Kaluzhny, Yulia
P12-58
Kamenickova, Alzbeta
P09-02, P22-03
Kamp, Hennicke
S16-4, P16-05
Kanak, Esin G
P08-01
Kanaki, Katerina
P07-19
Kandarova, Helena
P12-03, P12-12,
P12-34, P12-36,
P12-58
Kang, Hong-Seok
P15-27
Kanki, Masayuki
W13-5, P02-16
Kanno, Jun
S02-5, P16-11
Kansy, Manfred
S01-1
Karaaslan, Çagatay
P13-02
Karabiyikoglu, Gülseren
P16-14
Karacaoglu, Elif
P13-02, P19-09
Karlik, Wojciech
P12-77, P17-15
Karlsson, Hanna
P24-21
Karner, Tim
P08-40
Kim, Young Woo
P12-46, P12-49,
P12-73
Kim, Young-Lim
P12-27
Kimber, Ian
P06-04, P11-12,
P11-13
Kinsner-Ovaskainen, Agnieszka P16-02
Kirmizidis, George
P18-09
Kirsch, Taryn
P20-29
Lirsh, Richard
W09-3
Kitajima, Satoshi
P16-11
Kitteringham, Neil
W13-3
Kizek, Rene
P08-12
Kjeldsen, Lisbeth Stigaard
P12-60, P17-05
Klausner, Mitchell
P07-03, P07-25,
P12-12, P12-36,
P12-58, P12-59
Klein Entink, Rinke
P09-23, P11-04
Klein, Sebastian
P15-02
Kleinjans, Jos
S16-3, P10-20, P12-45, P12-85, P16-10
Klenke, Elisabeth
S09-1
Knapen, Dries
P08-20
Knebel, Jan
P12-04
Kneuer, Carsten
P17-01
Knulst, André
P09-09
Ko, Ahra
P20-20
Kobayashi, Maiko
P11-06
Kobayashi, Norihiro
S02-5
Koca, Deniz
P14-05
Kocalar, Kadir
P08-01
Koccour Kroupova, Hana
P01-05
Kock, Heiko
P12-04
Kodama, Yasuo
P23-09
Koerner, John
P22-04
Koh, Hyun Chul
P12-27
Kohler, Esther
P08-57, P15-15
Kohoutek, Jirí
P03-11
Koike, Eiko
P11-05, P25-15
Koitjärv, Meelika
P24-06
Koivisto, Pertti
P02-01
Kojima, Hajime
P12-89, P11-08
Kokkinaki, Aikaterini
P17-12, P17-13
Kokkinakis, Emmanuel
P17-07, P17-12,
P17-13
Kolaja, Kyle
S04-3
Kolár, Milan
P14-19
Kolarova, Jitka
P12-76
Kolárová, Veronika
P06-03
Kollar, Sarah
P13-09
Kolle, Susanne N.
P18-03
Kolorz, Michal
P07-30
Kolrep, Franziska
P14-27
Komulainen, Hannu
P08-11
Kongkachuichai, Ratchanee
P03-12
Koppen, Gudrun
P10-12
Kopp-Schneider, Annette
S03-1
Koraichi, Farah
P19-02
Korkalainen, Merja
P08-11
Kortenkamp, Andreas
W05-3, P08-24
Kosmider, Anita
P07-20, P12-16
135
Posters
Kartal, Yasemin
P04-12
Kase, Robert
S12-2
Kasemets, Kaja
P24-06, P24-23
Kato, Hirohito
P18-10
Kato, Reiko
P12-24
Kaur, Manbir
P07-22
Kaur, Navrinder
P23-02
Kavvalakis, Matthaios
P07-13, P07-19,
P09-01, P17-12,
P17-13, P17-18
Kawabata, Tom
P02-24
Kawada, Tomoyuki
P11-06
Kaya Akyuzlu, Dilek
P25-03
Kaya, Guerkan
P04-04, P23-04
Kaya, Seda
P08-36
Kayaalti, Zeliha
P04-12, P10-06,
P10-07, P10-08,
P08-36, P13-03,
P14-05, P14-14,
P14-15, P15-23,
P16-08, P16-14,
P25-03, P25-11,
P25-12
Kazanecki, Christian
P12-10
Kearney, Paul
P12-36
Kegler, Diane
P15-24
Kehrer, James P
W05-4
Keller, Detlef
W04-2, P05-06, P20-19
Kelm, Jens
P12-01, P12-55,
P12-70, P19-03
Kelsall, Janet
W13-5, P02-16
Kenawy, Sanaa
P23-11, P25-02
Kennedy, Marc
P20-09
Kerdine-Römer, Saadia
P12-80, P11-01,
P11-16
Ketelslegers, Hans
S10-1
Khang, Dongwoo
P24-05
Kharchenko, Olga
P07-14
Ki, Sung Hwan
P12-73
Kilic Süloglu, Aysun
P13-02
Kilic, Gozde
P24-15
Kille, Peter
W18-1
Kim, Chan-Kook
P20-33
Kim, Dal-Hyun
P25-24
Kim, Heyjin
P24-25
Kim, Hyun-Mi
P24-25
Kim, Ji Hoon
P12-30
Kim, Kwang-Mahn
P12-30
Kim, Kwang-Yon
P20-15
Kim, Kyu-Bong
P14-20, P14-21,
P14-22
Kim, Mee-ju
P12-30
Kim, Pilje
P24-25
Kim, Sang Chan
P12-46, P12-49,
P12-73
Kim, Sang-Hyun
P24-05
Kim, Sang-yub
P20-20
Kim, Wongyoung
P04-09
Kim, Yong-Bum
P25-24
Kim, Young bum
P18-25
Kostadinova, Radina
P20-22
Kotake, Yaichiro
P13-24
Kouretas, Demetrios
P02-14, P23-10
Koutedakis, Yiannis
P06-01
Kovacevic, Dragan
P23-05
Kovacova, Veronika
P08-12, P08-21,
P08-41
Kovalenko, Valentina
P13-10, P19-07
Kovarich, Simona
P05-16
Kovatsi, Leda
P07-13, P07-19, P17-07
Kozeli, Devi
P22-04
Kozubik, Alois
P03-06, P03-09
Kraehenbuehl, Stephan
P13-11
Kraemer, Thomas
K1-1
Kral, Jiri
P08-21, P08-41
Kramer, Stefan
P05-18
Krasteva, Maya
P06-04
Krause, Karl-Heinz
P12-26
Kreiling, Reinhard
P12-71, P14-03,
P15-22, P18-17
Krennrich, G
S16-4
Kreyling, Wolfgang G
S02-4
Krishan, Mansi
P07-17
Kroghsbo, Stine
W12-4
Kroll, Kevin
W18-4
Kropidlo, Aneta
P15-28, P18-22
Krug, Harald
P24-26
Kruizinga, AG
P09-23
Krul, Cyrille
P07-33, P11-02,
P11-04, P15-24, P19-13
Krupp, Eckart
S01-4
Kubina, Robert
P04-11
Kucera, Otto
P07-04
Kuczera, Katarzyna
P04-11
Kühne, Ralph
P20-38
Kumi, Justice
P09-08
Kunz, Petra
S15-3
Kunze, Marc
P02-06
Kuo, Lun-Cheng
P03-04
Kupny, Joanna
P18-22
Kurmayer, Rainer
P08-57
Kuroda, Yukie
P15-03
Kurokawa, Masahiko
P11-15
Kurokawa, Yoshika
P24-04
Kurppa, Sirpa
P17-14
Kurt, Bulent
P07-09
Kurti, Leonard
P02-04
Kusaka, Yukinori
P05-21
Kusakawa, Shinji
P03-13
Kustermann, Stefan
P12-35
Kuz’min, Victor
P24-24
Kwaa, Freda
P09-08
Kyriakakis, Michalis
P06-01, P09-01
Kyriakopoulou, Katerina
S12-4
Kyung, Min-Sik
P20-20
L
La Rocca, Cinzia
Lacroix, Marlène Z
136
P12-40
P19-01
Ladwig, Mechthild
P17-01, P17-03,
P17-17
Länge Reinhard
S12-3
Lafuente, Anunciacion
P08-31
Lafuente, Daisy
P08-38
Lahoz, Agustin
P12-45
Lambert, Amy
P12-61
Lambert, Carine
P08-10
Lambrechts, Nathalie
P12-57, P24-07
Lampen, Alfonso
P09-14, P14-04,
P14-27, P16-12,
P24-19
Landry, Timothy
P07-03
Landsiedel, Robert
P11-02, P15-14,
P18-03, P18-04,
P19-14, P23-13
Lanni, Cristina
W01-4
Lapenna, Silvia
P18-23
Larsen, John Christian
W17-2
Latado, Hélia
P09-13
Lavin, Martin
P16-07
Lawrence, Rachel
P15-25
Le Guevel, Rémy
P08-10
Lebailly, P
W02-5
Leclerc, Eric
P12-33
LeCluyse, Edward L
S04-5
Lecoeur, Sylvaine
P19-02
Ledieu, David
W10-1, P12-61, P13-21
Ledirac, Nathalie
P20-11, P18-19
Lee, Hee-Seok
P20-20
Lee, Jeong Eun
P12-27
Lee, Jong-Hyeon
P20-33
Lee, Kwangwon
P07-06
Lee, Kyoung-Youl
P01-01, P08-27
Lee, Meeyoung
P18-25
Lee, Mee-Young
P01-01
Lee, Moung Sook
P14-03, P15-22,
P18-17
Lee, Seung-Youl
P20-20
Lee, Soo Jin
P17-06
Lee, Soyoung
P24-05
Lee, Su Hyon
P12-05, P12-06,
P12-07
Lee, Syng-Ook
S18-2
Lee, Young Joon
P12-72
Leeuwen, F. X. Rolaf van
P20-26
Legay, Silvan
P15-02
Legler, Juliette
P20-36
Legradi, Jessica
P20-36
Lempiainen, H
W10-3, W13-1
Lenoir, Joke
P15-21
Lenz, Barbara
P13-04
Lenze, Dido
P09-14
Leonard, Martin
S03-1
Leoni, Anne-Laure
P02-06, P15-07,
P25-06
Leppänen, Jukka
P14-24
Leroy, Mariline
P19-16
Letasiova, Silvia
P07-25, P12-12,
P12-36, P12-59
Lubinski, Lukasz
Lucas, Rui
Lucena, Kaline
Luckert, Claudia
Luft, Jörg
Lühe, Anke
Luisier, R
Lukas, Arno
Luo, Man
P24-24
P04-08
P12-14
P09-14
P15-05
S01-1
W10-3, W13-1
S03-1
P24-12
M
M. Kratz, Jadel
P05-19
M. T. Fernandes, Raquel
P15-30
Macadam, David
P11-09
Macejova, Dana
P08-23, P08-47
Machala, Miroslav
P03-06, P03-09,
P03-11, P13-17
Machat, Jiri
P08-12
Machera, K
S12-1
Macida, Kazuhiko
P03-13
Macit, Enis
P07-09, P07-11
Madden, Judith
W16-2, P05-04,
P05-08, P24-24
Madsen, Charlotte B
W12-4
Maeno, Tomokazu
P24-09
Maggiore, Angelo
P18-23
Mahajan, V
W15-2
Mahmoud Deabes, Mohamed
P09-19
Maia Campos, Patrícia
P21-03
Maiello, Raffaele
P02-02, P24-18
Maïga, Ababacar
P25-20
Mainero Rocca, Lucia
P02-23
Mair, Christina E.
P05-19
Maisanaba, Sara
P09-03, P09-05,
P09-06
Maistro, Edson
P10-05
Makita, Masahiro
P23-15
Makovec, Darko
P24-22
Malachova, Katerina
P08-56
Malard, Véronique
P13-06
Maleki, Zohreh
P25-07
Malhotra, Manav
P07-22
Mally, Angela
S05-3
Manda, Gina
P02-19
Mandakas, Xenofon
P07-19
Mandic-Rajcevic, Stefan
W02-3
Mandy, Fisher
P25-26
Manelfi, Candida
P05-16
Mangelsdorf, Inge
P20-38, P24-16
Mankus, Courtney
P12-03
Mankus, Courtney
P12-34
Manser, Pius
P24-26
Mansour, Hayam
P09-19
Mantecca, Paride
P24-08
Manzano-Leon, Natalia
P08-32
Manzo, Luigi
P04-02
Manzoli de Sá, Júlia S.
P09-10
Mao, Lin
P12-53
Marabini, Laura
P12-87
Posters
Letcher, Robert J.
P08-59
Leuschner, Renata
P20-12
Leva, Paolo
P08-44
Leverett, Dean
S15-3
Lewin, Geertje
S11-4
Lewis, Dick W
R01-3
Li, Lei
P23-08
Li, Lih-Ann
P03-04
Li, Qiang
P12-71, P15-22
Li, Qing
P11-06
Li, Wen-Hsuan
P20-24
Li, Yao
P12-65
Li, Yufeng
S02-2
Liao, Vivian
P13-20, P20-24
Lichtensteiger, Walter
P08-24
Lichtenstein, Dajana
P24-19
Liebsch, Manfred
P12-04
Liechti, Matthias E.
P04-06
Lim, Kyoung Min
P12-06
Lim, Kyoungsoo
P02-18, P04-09
Lima, Lidia
P20-37
Lin, Chun-Ju
P03-04
Lin, Pinpin
P08-55
Linares, Victoria
P08-38
Link, Kerstin
P10-19
Link, William
P22-04
Linsel, Gunter
P12-04, P15-12
Lipsa, Dorelia
P08-44
Liu, Chunlei
W15-1
Liu, Jia-Hui
P24-20
Liu, Xiang-yun
P23-08
Liu, Ying
S02-2
Liu, Yuanfang
P24-20
Lizarraga, Daneida
P10-20
Llana Ruiz-Cabello, Maria
P09-03, P09-04,
P09-07
Llovet, Isabel
P08-38
Lo Piparo, Elena
W16-3
Lo Scalzo, Roberto
P12-87
Locatelli, Carlo
P04-01, P04-03,
P04-02
Löffler, Alexandra
P13-14
Loizou, George
K6-1
Lonati, Davide
P04-01, P04-03,
P04-02
Long, Manhai
P03-02, P08-59,
P12-28
Longo, Daniela
P02-05
Looser, Ralf
S16-4, P16-05
Lopez, Fabiola
P12-74, P20-03
López-Franco, Esperanza
P01-03
Lopez-Villegas, Tania
P08-32
Lo Piparo, Elena
W04-5
Lorenz, Helga
P02-13
Loret, Thomas
P08-26
Losos, Jan
W09-3
Loss, Carla Giane
P15-30
Losurdo, Anna
P04-03
Lourdes Bastos, Maria
P13-16, P14-18
Lovsin Barle, Ester
P18-07
137
Maravgakis, Georgios
P17-07, P17-12
Marcellin, Magali
W10-3, W13-1,
P12-13, P12-61
Marchan, Rosemarie
P12-70
Margina, Denisa
P02-14
Margina, Denisa
P02-19
Maria Drumond Chequer, Farah P10-23
Marinho, Aline T
P14-01
Marko, Doris
P10-22
Markovic, Darko
P07-18
Marowsky, Anne
P13-09
Marques, Eduardo
P10-05
Marques, M Matilde
P14-01
Marques, Marcella Camargo
P10-14
Marquis, Judith
P03-03
Marreilha dos Santos, Ana Paula P04-08
Marrer, E
W13-1
Marsden, Edward
P19-15, P19-16
Marshall, Valerie
P18-02
Martín Conde, José Antonio
P22-02
Martin, Elizabeth
P25-27
Martin, Fabiana
P06-02
Martin, Florian
P12-75
Martin, Stefan F.
P11-01
Martinais, Sophie
P08-10
Martín-Cameán, Ana
P08-16, P08-19,
P08-18
Martinez, Maria Aranzazu
P12-37, P12-50
Martinez, Marta
P12-37, P12-50
Martinez-Larrañaga, Maria Rosa P12-37, P12-50
Martins, Marlon
P20-37
Martos, Suzanne
P12-54
Marty, Sue
P18-02
Martyniuk, Christopher J
W18-4
Marx-Stoelting, Philip
P17-01, P17-03,
P17-17
Marzocco, Stefania
P12-40
Masci, Paul
P16-07
Mascolo, Maria Grazia
P12-17
Masubuchi, Yasuhiro
P23-15
Masuda, Kyoichi
P13-24
Mate, Alfonso
P09-03
Matelska, Sara
P08-53
Mateo-Fernandez, Marco
P10-02, P09-24
Mathavan, Sinnakaruppan
P23-02
Mathis, Carole
P12-75, P16-13
Matovic, Vesna
P08-09, P08-22,
P20-13
Matsumura, Astushi
P23-15
Matsuoka, Atsuko
P12-24
Matsuyama, Takashi
P18-10
Mattila, Tuomas
P17-14
Matunaga, Tadashi
P15-06
Matuskova, Zuzana
P14-19
Maunz, Andreas
P05-18
Maurella, Cristiana
P02-05
Mayer, Alejandro
P11-09
Mazallon, Michelle
P19-02
Mazzoleni, Marta
P04-03
McCoy, Alene
P18-01
138
McFadden, Lisa
P18-01
McGinnis, Claudia
P12-88, P23-02
McMullin, T
S07-4
McNamee, Pauline
P18-09
McWhirter, Derrick
W13-3
Meecham, Kenneth
P18-14
Meehan, R
W10-3
Meek, Thomas
W09-3
Meerman, John
P12-02
Mégarbane, Bruna
S13-3
Mehinto, Alvine
W18-4
Mehling, Annette
P18-03, P18-04
Meier, Stefanie
P02-06
Meinl, Thorsten
P05-08
Meirelles, Antonio
P09-18
Meistro, Serena
P02-05
Melching-Kollmuss, Stephanie
S15-2
Melega, Simone
P12-62
Mellert, Werner
S16-4, P16-05
Meloni, Daniela
P02-21
Mendel, Marta
P12-77, P17-15
Mendoza, Paula
P11-14
Menegola, Elena
P19-10
Menéndez Quintanal, Luis ManuelP04-14
Menke, Aswin
W11-4, P07-33
Mennecozzi, Milena
P05-13
Menouer, Dounia
P08-03
Mercadante, Adriana Zerlotti
P10-14
Meredith, Clive
P10-13, P12-82
Merinas-Amo, Maria Tania
P10-02, P09-24
Merino Alonso, Javier
P22-02
Merlier, Franck
P12-33
Mermoud, Julien
P12-23
Merrill, Christine
W09-3
Mertens, B.
21
Merz, Karl-Heinz
P20-32
Mesaric, Tina
P24-22
Mesens, N
W11-4
Mesnil, Marc
W07-3
Messner, Simon
P12-55, P12-70
Metruccio, Francesca
P19-10
Meulenbelt, Jan
P05-03
Michelangeli, Francesco
P12-11
Mika, Paulina
P19-13
Miksys, Sharon
P14-24
Mikulaskova, Hana
P08-49, P08-50
Milani, Raquel Fernanda
P09-11
Milasova, Tatiana
P12-12
Milcova, Alena
P12-25
Milic, Dinka
P23-05
Millar, Mike
P13-12
Mills, EN Clare
W12-5
Minakuchi, Kazuo
P08-13
Miranda, Joana P.
P03-05, P07-15,
P09-15, P12-21,
P12-22, P14-01
Misato, Kazuki
P14-28
Mishra, Ravinesh
P07-05
Mishra, Sanghamitra
P20-34
Mitchell, David
P15-25
Mueller, Patrick Y
Mueller, Stefan O
Mujeeb, Mohd
Mülayimcelik Özgün, Gökcen
Mulder, Mariska
Muldoon Jacobs, KL
Mule, Nandkishor
Müller, Daniel
Müller, Margit
Müller, Lutz
Munn, Sharon
Muralidhara, M
Murk, Albertinka J.
Myagkova, Marina
Myöhänen, Kirsi
Myoung joo, Park
Myung Ae, Bae
S01-2
S03-1, P12-56
P17-02
P19-09
P18-27
W04-2
P13-09
P08-42
P10-19
S09-2
W05-2, P13-15
P23-12
P12-42, P20-26
P07-13
P18-23
P15-20
P15-20
N
Nagase, Hisamitsu
P13-23
Nagatsuka, Shin-Ichiro
P16-06
Nagel, Georg
P03-07
Naito, Mikihiko
P24-09
Nakae, Dai
P24-09
Nakanishi, Tsuyoshi
P13-23
Nakashima, Mikiro
P16-06
Nakasono, Satoshi
P15-06
Nam, Gi-baeg
P12-30
Nam, Mi-Hyun
P07-06
Narayanaperumal, Senthil
P13-22
Nassirpour, Rounak
W13-5, P02-16
Natsch, Andreas
W01-3
Nawaz, Ahmad
P17-04
Nawrot, Tim
P19-04
Neagoe, Ionela
P02-19
Neagu, Daniel
P05-07
Neca, Jiri
P03-06
Nelissen, Inge
P24-07
Nelms, Mark
W16-2, P05-05,
P05-06, P05-08
Nemcova, Barbora
P08-49, P08-50
Nemery, Benoit
S13-2
Neri, Maria Teresa
P15-18
Neuenhahn, Patricia
P25-06
Newham, Pete
W09-1
Ni, Qingshun
P24-12
Nicola, Claudia
P20-05
Nicolas, Jean-Francois
P06-04
Nicole, Mitchell
P09-08
Niederhauser, Urs
P13-04
Niehoff, Marc
P22-05
Niemann, Birgit
P24-19
Niemann, Lars
P17-01, P17-03,
P17-17
Niggemann, Birgit
P22-05
Nijmeijer, Bart
P01-04
Nikolic, Damjan S.
P23-04
Nikolic, Dragica
P20-14
Nikolov, Nikolai G
P05-22
Posters
Mitchell, Jane
P12-84
Mitlianga, Paraskevi
P09-01
Mittal, Deepak Kumar
P08-43
Miura, Nobuhiko
P25-16
Miyajima-Tabata, Atsuko
P12-24
Miyara, Masatsugu
P13-24
Miyazawa, Kun’ichi
P24-09
Mizogami, Maki
P07-26
Mlcakova, Veronika
P08-12
Mlynarcikova, Alzbeta
P08-25
Moggs, Jonathan
W10-3, W13-1,
W13-3, P12-61
Mohamed, Laila
P09-19
Mohammadi Karakani, Ali
P02-20
Möhle, Niklas
P12-09, P12-66
Mohr, Susanne
S01-1
Moilanen, Arja
P08-11
Mokhtari, Abdelrhani
P25-20
Mokshina, Elena
P24-24
Molander, Linda
P20-18
Molina-Villalba, Isabel
P02-10, P02-11,
P08-16, P20-31
Mollo Filho, Pedro Carlos
P15-30
Moltó, Juan Carlos
P09-17
Momas, Isabelle
P08-26
MOMAS, Isabelle
P08-45
Monnet-Tschudi, Florianne
P12-23, P12-83
Monteiro, Márcia
P15-09
Montoya Parra, Gina Alejandra S16-4, P16-03,
P16-04
Moon, Kyoung-Sik
P25-22, P25-24
Morandi, Elena
P12-17
Morandy, Gregory
P07-02
Moran-Pineda, Marina
P08-32
Mörbt, Nora
P10-19
Moreira, Daniele C.F.
P09-10
Moreno, Isabel
P08-17
Moretto, Angelo
S07-5, S15-5,
P19-10
Morgano, Marcelo A
P09-10, P09-11
Mori, Takahide
P14-28
Morisset, Typhaine
P20-28
Morita, Fumio
P23-09
Morita, Takeshi
P10-09
Moritz, Wolfgang
P12-01, P12-55,
P19-03
Morolli, Bruno
P10-03
Morozova, Vitalia
P07-13
Morse, Jessica
P10-18
Mortensen, Alicja
W17-2
Mortimer, Monika
P24-06
Mosbah, Rachid
P01-06, P19-17
Mosca, Mariane
P06-02
Moserova, Michaela
P03-10
Mostrag-Szylchtying, Aleksandra P05-05, P05-06
Moulin, P
W10-3, W13-1
Moyano, Rosario
P09-06
Mrzyk, Inga
P15-28, P18-22
Mueller, A
W10-3, W13-1
Mueller, Matthias
S04-2
139
Nilsson, Charlotte
Niniraki, Sofia
Nishikawa, Jun-ichi
Nishimaki-Mogami, Tomoko
Nishimura, Tetsuji
Nitta, Hiroshi
Niu, Xiaoyu
No, Kyoung Tai
Noh, Jung-Ho
Nohynek, Gerhard J
Nörenberg, Astrid
Norvès, Benoit
Novakova, Zuzana
Novicki, Deborah
Novotna, Aneta
Novotny, Ladislav
Ntziachristos, Vasilis
Núñez Díaz, Salvador
Nydlova, Erika
P18-15
P17-13
P13-23
P24-09
P24-09, P24-11
P24-04
P12-63
P20-15
P25-22, P25-24
W17-4
P12-38
P20-08
P12-25
P18-27
P22-03
P08-41
W15-5
P22-02
P07-04
O
O’Connor, Robert
P20-02
Oakeley, E
W13-1
Oberemm, Axel
P16-12
Öberg, Mattias
P20-30, P18-05
Odabasi, Miyase
P25-12
Odekunle, K.
P08-30
Odermatt, Alex
P04-06, P07-02,
P08-54, P12-83,
P12-88, P13-07,
P15-08
Odukoya, O. O.
P08-30
Oertel, Antje
P12-04
Oesch, Franz
K4-1
Ogata, Akio
P24-09
Oh, Bumjin
P02-18, P04-09
Oh, Ji Sun
P07-06
Ohkubo, Shuichi
P23-09
Ohl, Peter
P05-08
Ohta, Satoshi
P05-10
Ohta, Shigeru
P13-24
Ohtani, Katsumi
P25-16
Okuda, Katsuhiro
P13-24
Okuhira, Keiichiro
P24-09
Olagüe, Cristina
P01-03
Oldach, Jonathan
P12-03
Olie, Daniël
P05-03
Oliveira, Helena
P24-13
Oliveira, José Miguel
P24-13
Oliveira, Nuno G
P03-05, P07-15,
P09-15, P12-21,
P12-22
Olmedo, Pablo
P02-10, P02-11,
P20-31
O’Lone, Raegan
W13-5, P02-16
Olsen, Jørn
P03-02
Ombelet, Willem
P19-04
Omoruyi, Iyekhoetin Matthew
P09-20
Ondracek, Karel
P08-21
140
O’Neill, Marie
P08-32
Ono, Atsushi
P18-10
Orhan, Hilmi
S17-1
Orjuela, Anette
P14-13
Ortega, Richard
P13-06
Ortiz-Martinez, Raul
P02-07
Oshikata-Miyazaki Miyazaki,
AyumiP15-03
Osickova, Jitka
P08-12, P08-21,
P08-41
Osornio Vargas, Alvaro
P08-32
Ostapchenko, Lyudmyla
P07-14
Ostrowska, Agnieszka
P07-20, P12-16
Oun, Rabbab
P07-16
Overvad, Stine
P03-02
Ovcinnikovs, Vitaly
P11-13
Ozawa, koichiro
P13-24
Özkan Vardar, Deniz
P10-16
P
P. Mason, Ronald
P08-13
Paçarizi, Hidajet
P02-04
Paci, Enrico
P02-02, P20-07
Paes, Cintia
P06-02
Page, Leanne
P20-02
Paini, Alicia
P05-12, P05-13
Pajeva, Ilza
P05-23
Palate, Bernard
P19-08
Paleologo, Maurizio
P02-21
Paliwal, Sarvesh
P07-22
Pallardy, Marc
S06-3, P12-80, P11-01, P11-16
Pallocca, Giorgia
P12-52
Palmeira, Andreia
P14-18
Palmeira, Carlos
P13-16
Pamies, David
P12-52
Pan, Min-Hsiung
P03-01
Panagiotaki, Georgia
P17-13
Pandejpong, Denla
P04-07
Pandey, Kanti Bhooshan
P08-48
Paneda, Astrid
P01-03, P19-05
Pantelakos, Stavros
P14-17
Papa, Pietro
P04-01
Papadaki, Paschalina
S12-4
Papaleo, Bruno
P20-07
Papoutsi, Maria
P13-21
Paranjpe, Madhav
P18-13, P18-11
Paranjpe, Madhav
P18-12
Parent-Massin, Dominique
P20-17
Park, Eun Jung
P22-04
Park, Jae Hyun
P12-27
Park, Junghyun
P20-33
Park, Kevin
S17-4, W13-1, W13-3
Park, KunHo
P20-33
Park, Kwangsik
P24-25
Park, Kyung-Hun
P12-27, P17-06
Park, Song-Yi
P20-20
Park, Soo-Jin
P12-27, P14-09,
P14-10, P14-11
Pieters, Raymond
W01-2, P11-02, P15-24
Pikula, Jiri
P08-12, P08-21,
P08-41
Pinches, Mark
W10-2
Pinheiro, Pedro F
P14-01
Pinto, Antonella
W01-4
Pinto, Ernani
P08-33
Pique, Céline
P19-15
Pires Bianchi, Maria Lourdes
P10-23
Pirow, Ralph
P12-04
Pitardi, Danilo
P02-21
Pizzo, Fabiola
P12-39, P25-21
Pla, Antonio
P02-10, P02-11,
P20-31
Plappert-Helbig, Ulla
P07-02
Plautz, J
W04-3
Platten, Michael
S18-1
Platzek, Thomas
W17-1
Pleadin, Jelka
P23-05
Plumb, Jane
P07-16
Plummer, Simon
P13-12
Poelstra, K
W15-2
Pognan, Francois
P12-13, P12-20,
P12-61, P13-21
Pohanka, Miroslav
P08-41
Pohjanvirta, Raimo
P09-20
Pohl, Christine
P12-66
Polat, Hivda
P03-14
Polichetti, Giuliano
P08-05, P08-06,
P25-19
Polichetti, Raffaele
P08-05, P08-06
Polyvanaya, Oksana
P07-13
Pontal, Pierre-Gérard
P20-08, P20-11,
P18-19
Poplawska, Magdalena
P07-20, P12-16
Popova, Dina
P12-43
Porebski, Gregory
P02-24
Porto, Beatriz
P02-08
Porvari, Petri
P17-14
Posada Estefan, Olga Maria
P04-05
Postic, Cindy
P20-28
Poth, Albrecht
P19-14
Poulianiti, Konstantina
P06-01
Poussin, Carine
P16-13
Pratsinis, Sotiris
P24-10
Pratt, Iona
W17-2
Preusting, Hans
P01-04
Price, Anna
S03-1, P12-52
Price, Leo
P12-02
Price, Paul
S15-3
Prieto, Ana I
P08-17
Prieto, Pilar
S03-1
Prokoudine, A
S16-4
Prouillac, Caroline
P19-02
Przybylak, Katarzyna
P05-08
Puel, Sylvie
P19-01
Puerto, Maria
P09-03, P09-05,
P09-06,P09-07
Puiu, Maria
62
Puls, Imke
P07-32
141
Posters
Park, Yong Jin
P08-51
Parker, Christian
S04-2
Parmentier, Céline
P12-56
Parracino, Antonietta
P16-01
Parry, Joel
W09-3
Partosch, Falko
P05-18
Paschalaki, Koralia
P12-84
Paula Venancio, Vinicius
P10-23
Paullier, Patrick
P12-33
Pavlikova, Jitka
P12-25
Pawlowska, Monika
P18-22
Pearson, Nick
P07-21
Pecaric Pekovic, Tatjana
P02-24, P20-21,
P11-03
Pedersen, Gitte Alsing
P12-15
Pedersen, Mikael
P12-15
Peijinenburg, Ad A.C.M.
W01-1, P12-42
Peijnenburg, Ad
P11-11
Peitsch, Manuel C.
P12-75, P16-13
Pelclova, Daniela
S13-1, P02-12
Pelkonen, Olavi
S09-5
Perdichizzi, Stefania
P12-17
Pereira, Frederico C.
P23-01
Pereira, Sofia A
P14-01
Pereiro, Natividad
P08-31
Pérez Martínez, Ángel Luis
P04-14
Pérez, Denisa Soledad
P09-25
Pernthaler, Jakob
P08-57, P15-15
Perrier, Noel
P25-23
Perron Lepage, Marie-France
P19-16
Perron, Josee
P15-01
Perši, Nina
P23-05
Persoz, Charles
P08-26
Péry, Alexandre
S12-1, S12-4, P05-07
Peschar, Maaike
P07-34
Petri-Fink, Alke
P12-29
Petrochenko, Svetlana
P07-13
Petrolini, Valeria
P04-01, P04-03,
P04-02
Petry, Harald
P01-03, P01-04,
P19-05
Petry, Thomas
P20-34, P18-18
Pettit, Syril
P22-04
Pezzolato, Marzia
P02-05, P02-21
Pfaller, Walter
S03-1
Pfannenbecker, Uwe
P18-09
Pfeil, Rudolf
P17-01, P17-03,
P17-17
Pflugmacher, Stephan
P08-58
Pfuhler, Stefan
P10-10
Phillips, Timothy
P09-08
Piao, Yin-zhu
P12-30
Piasek, Martina
P08-34
Picard-Hagen, Nicole
P19-01
Pichardo, Silvia
P09-03, P09-04,
P09-05, P09-06,
P09-07
Pichler, Werner J.
S06-4, P02-24, P13-11, P20-21, P11-03
Piersma, Aldert H
S11-2, W14-3, P19-13
Pungier, Jacquemine
Purdel, Nicoleta Carmen
Putnoky, Salomeia
Puzyn, Tomasz
P06-04
P20-04, P20-05
62
P24-24
Q
Queiroz, Diana
Quesada, Paul
Quezada-Tristan, Teodulo
Quintaes, Késia D.
Quintana-Belmares, Raul
P06-02, P08-52,
P12-14, P15-29
P19-15
P02-07
P09-10
P08-32
R
Raaijmakers, Jan
P15-24
Racchi, Marco
W01-4
Rach, Jessica
P12-09
Ragas, Ad MJ
S12-5
Rahmani, Roger
P12-81, P17-04
Rahnasto-Rilla, Minna
P14-24
Raisuddin, Sheikh
P08-29
Ramaiahgari, Sreenivasa
P12-02
Ramirez Martinez, Alejandra
P20-17
Ramirez, Tzutzuy
P16-05, P19-14,
P23-13
Ramos, Eva
P12-37, P12-50
Randak, Tomas
P01-05, P12-76
Randi, Anna
P12-84
Ranggasami, Nirmala
P18-18
Raoufi, Ahmad
P23-03
Räsänen, Kati
P17-14
Rashid, Mohd
P07-05
Rasoulpour, Reza
P18-02
Rast, Peter
P24-10
Rathfelder, Nicole
P12-61
Rathman, James
P05-02, P05-05
Rattarittamrong, Rachawadee P04-07
Raunio, Hannu
P14-24
Reddy, Julian
P18-20
Reed, Daniel
P12-84
Reefman, Esther
P11-04
Rehman, Muneeb
P25-10
Reichmann, Gaby
S06-2
Reig, Vanessa
P11-14
Reinders, Judith
P11-02
Reinert, Knut
S03-1
Reisinger, Kerstin
P10-03, P10-04
Reißig, Sonja
P03-07
Remião, Fernando
P13-16, P14-18,
P23-14
Remon, Jean Paul
P15-21
Renieri, Elisavet
P17-18
Renwick, A
W04-5
Riccardi, Elena
P15-18
Richarz, Andrea
W16-2, P05-04,
9P12-11, P05-08,
P05-16, P24-24
Richelmi, Guia Benedetta
P02-05
142
Richert, Lysiane
S03-1, P12-44, P12-56
Ridings, Jim
W14-2
Riebel, Virginie
P12-13
Rieke, Svenja
P17-01, P17-03,
P17-17
Rielland, Aurelie
P20-16
Rieswijk, Linda
P10-20
Rietjens, Ivonne M. C. M.
W17-2, P12-42, P20-26
Rihel, Jason
W11-2
Rijo, Patrícia
P21-03
Rimondo, Claudia
P04-01
Ringblom, Joakim
P20-30
Rios, Victoria
P08-17
Ritter, Detlef
P12-04
Rivedal, Edgar
W07-4
Rivolta, Marina
P25-21
Rizvi, Syed Ibrahim
P08-48
Roberts, David
P05-04
Roberts, Ruth A
S10-4
Robin, Marie-Anne
P08-03, P08-10
Robinson, Sally
W06-1
Rocchi, Loretta
P04-01
Rocha, Bianca
P06-02
Rodrigues, Luís
P21-03
Rodrigues, Oscar E.D.
P13-22
Rodriguez Carrasco, Yelko
P09-17
Rodriguez, Frédéric
P19-02
Rogalska, Joanna
P13-19, P13-25,
P25-05
Roggen, Erwin
P11-02
Rogue, Alexandra
P07-21
Rohrer, Sebastian
P05-11
Rojas-Bracho, Leonora
P08-32
Rolandi, Laura
P04-01
Rollinger, Judith M.
P05-19
Romero, Alejandro
P12-37, P12-50
Romero-Jimenez, Magdalena
P10-02, P09-24
Rondel, Karine
P08-10
Roos, Robert
P20-35
Roper, C
W04-3
Roquemore, Liz
P12-31
Rosa, Bruno
P15-18
Rosa, Vivian
P06-02
Rosado, Catarina
P21-03
Rosalovsky, Volodymyr
P17-11
Rosas, Irma
P08-32
Rosenmai, Anna
P12-15
Rossi, François
P16-01, P16-02
Rossner, Pavel
P12-25
Rossnerova, Andrea
P12-25
Rostani, Amin
S03-1
Roszczenko, Alicja
P13-19, P25-05
Roth, Adrian B.
P12-35, P12-88, P13-04
Roth, Nicolas
S12-4
Roth, Thomas
P18-06
Rothe, Helga
W04-3, P20-02
Rothen-Rutishauser, Barbara
P12-29
Rotondo, Francesca
P12-17
Roudeau, Stéphane
P13-06
Roudot, Alain-Claude
P20-17, P20-28
P07-04
P07-16
W04-3
W02-3
P04-14, P22-02
P02-12
P20-18
P25-06
S04-2
P13-18
P12-40
S10-3
P02-12
P08-56
P02-18, P04-09
S
S. Guerreiro, Patrícia
P03-05
Saba saba, Falak Beigh
P08-28
Sacco, Maria Grazia
P12-52
Sachnik, Thomas
P12-88
Saengsuri, Pornwanad
P04-07
Safe, Stephen
S18-2
Safford, R
W04-2
Sage, Nicole
P13-06
Sagelsdorff, Peter
P11-14, P20-25
Sahin, Nefise Ozlen
P10-11
Sahin, Tolga
P10-01, P10-15
Saiakhov, Roustem
P05-01
Sakai, Keiko
P12-24
Sakamoto, Yoshimitsu
S02-5, P24-09
Sakuratani, Yuki
P05-10
Sala Benito, José Vicente
P05-12, P05-13
Salah El din, Doha
P09-19
Salmon, Florence
P01-03, P01-04,
P19-05
Salyha, Yuriy
P17-11
Samizo, Shigeyoshi
P13-24
Sampaio, Klicia
P09-18
Sampedro, Ana
P01-03
Samson, Leona D.
P03-07
Sanchez, Brisa
P08-32
Sandström von Tobel, Jenny
P12-23
Sanoh, Seigo
P13-24
Santos, Conceição
P24-13
Santos, Dinamene
P04-08
Santos, J Miguel
P12-21
Santos Junior, Julio César
P15-30
Saraiva, Nuno
P03-05
Saraiva, Rogério de Aquino
P13-22
Sari, Sibel
P07-29
Sarigöl, Zehra
P12-19
Sá-Rocha, Vanessa
P12-14
Saron, Elisabete Segantini
P09-11
Sato, Kazuhiro
P05-21
Sato, Yoji
P03-13
Saurat, Jean-Hilaire
P02-12, P04-04,
P23-04, P23-16
Sawada, Rumi
P03-13
Sawada, Stefanie
P16-12
Saxena, Rajiv K
P17-10
Saxer-Sekulic, Nikolina
P04-04, P23-04
Sayal, Ahmet
P04-12
Sayal, Ahmet
P07-11
Saygi, Sahan
P10-11
Scarpellini, Manuela
P15-18
Schadt, Heiko
P13-21
Schaefer, Kai
P02-13
Schäfer-Korting, Monika
P15-14
Schanz, Johanna
P12-10
Scherbichler, N
W10-3, W13-1
Schilter, Benoit
W04-1, W16-1
Schins, Roel
P12-29
Schlatter, Harald
P06-04
Schleh, Carsten
P15-07, P25-06
Schleifer, Klaus-Juergen
P05-11
Schlumpf, Margret
P08-24
Schmeits, Peter C
W01-1
Schmid, Sandra
P15-07, P25-06
Schmidt, Flavia
P17-01, P17-03,
P17-17
Schmidt, Thomas
P08-39
Schmidt-Posthaus, Heike
P01-05
Schmitt, Georg
W14-1, P18-16
Schmuczerova, Jana
P03-06, P12-25
Schnabel, J
W04-5
Schneider, Martin
P07-02
Schneider, Steffen
S11-1, S15-2
Schnuch, Axel
P06-04
Schoeters, Greet
P10-12, P12-57
Scholz, Gabriele
P09-13
Schönlau, Christine
P19-14
Schreiber, Nicole B.
P12-39, P12-41
Schrenk, Dieter
P05-11, P20-32
Schröder, Katrin
P24-16
Schröder, Olaf
S03-1
Schropp, Patricia
P25-06
Schröter, Anika
P10-22
Schrumpf, Laura
P25-09
Schug, Markus
P12-62
Schuh, Werner
P06-04
Schuhmacher-Wolz, Ulrike
P18-21
Schuler, Franz
P12-35
Schulthess, Pascal
P13-14
Schulze, Johannes
P08-42, P20-27,
P25-09
Schulze, Michaela
P25-09
Schuster, Daniela
P05-19
Schuster, Ingrid
P02-06
Schuster, Paul X
P18-04
Schüürmann, Gerrit
S12-1, P20-38
Schwald, Marianne
P13-21
Schwarz, Michael
W10-3, W13-1, P13-14
Scian, Mariano
P02-25
Searfoss, George
W13-5, P02-16
Sedlackova, Jana
P08-12
Seeland, Madeleine
P05-18
Segal, Lawrence
P18-27
143
Posters
Rousar, Tomas
Rowan, Edward
Rua, D
Rubino, Federico Maria
Rubio Armendáriz,
María del Carmen
Rudaz, Serge
Rudén, Christina
Rudragowda, Shivakumar
Ruffner, Heinz
Rushchak, Volodymyr
Russo, Rosario
Rusyn, Ivan
Rutledge, Douglas
Rybkova, Zuzana
Ryoo, SeungMok
Segner, Helmut
P20-36
Segredakis, John
P23-10
Seibert, Julia
P04-06
Seidel, Albrecht
P11-07, P14-04
Selderslaghs, Ingrid
W11-1
Selmanoglu, Güldeniz
P13-02, P19-09
Seo, Changseob
P18-25
Seo, Dongwoo
P04-09
Sepcic, Kristina
P24-22
Serce, Hakan
P02-15
Serchi, Tommaso
P15-02
Serhatli, Muge
P03-14
Seri, Catia
P04-01
Serpelloni, Giovanni
P04-01
Serrano, Ana Belén
P09-16
Serrano, Jesus
P08-32
Sert, Selda
P13-03
Seta, Nathalie
P08-26, P08-45
Severino, Lorella
P12-40
Sewer, Alain
P16-13
Seyrek, Melik
P07-09, P07-10,
P07-11
Sezimova, Hana
P08-56
Shah, Rashmi R
S14-1
Shao, Erlei
P24-12
Shao, Jia
W01-1, P11-11
Shao, Yue
P23-08
Shaposhnikov, Sergey
P15-19
Sharapova, Tatiana
W13-5, P02-16
Sharkey, Jack
W13-3
Sharma, Rahul
P12-48
Shayakhmetova, Ganna
P13-10, P13-18,
P19-07
Sheets, LP
S07-4
Shiiki, Ayano
P23-15
Shimada, Takashi
P16-06
Shimizu, Kumiko
P11-08
Shin, Hyeunkyoo
P18-25
Shin, Jihye
P20-33
Shin, Kyeho
P12-30
Shin, Min-Ki
P20-20
Shoara, Saghar
P25-08
Shvedova, Anna A
S02-3
Siddarth, Manushi
P17-08
Siddeek, Benazir
S15-2
Siddique, Nadeem Ahmad
P17-02
Siddiqui, Anees
P07-22
Siddiqui, Anees A
P07-05
Silingardi, Paola
P12-17
Silva, Ana L. D.
P24-13
Silva, Fabio F.
P09-11
Silva, Renata
P13-16, P14-18
Silva, Susana
P02-08
Simoneau, Catherine
P09-12
Sims, Jennifer
S01-5
Singer, Thomas
S01-1, P12-35, P13-04, P18-16
Sirivarasai, Jintana
P02-03
Sitarik, Alexandra
P08-32
Skalicka-Wozniak, Krystyna
P12-77
144
Skinner, Matt
S14-5, P22-04
Skochova, Hana
P08-21, P08-41
Skov, Kasper
P21-01
Smerdova, Lenka
P03-06
Šmerdová, Lenka
P03-11
Smiesko, Martin
W16-4
Smirnova, Lena
P12-04, P12-54
Smith, Thomas
P18-27
Smits, Mieke
P11-02
Snel, Cor
P07-33
Soares, Stellamaris
P20-37
Sohn, Changhwan
P02-18, P04-09
Solano, Enrique
P08-16, P08-19,
P08-18
Solecki, Roland
R01-4
Son, Hwa-Young
P01-01
Sone, Hideko
P24-04
Sonne, Christian
P08-59
Sonnemans, Marc
P01-03, P01-04,
P19-05
Soraci, Aleajandro Luis
P09-25
Sorg, Olivier
P02-12, P04-04,
P23-04, P23-16
Sornat, Robert
P15-28, P18-22
Sostare, Jelena
P12-11
Soulaymani, Abdelmajid
P25-20
Soulaymani-Bencheikh, Rachida P25-20
Sousa, Emília
P14-18
Souza, Samira
P20-37
Söderberg, Magnus
S05-4
Söylemez Gökyer, Derya
P16-08
Söylemez, Esma
P10-06, P10-07,
P10-08, P13-03,
P14-05, P14-14,
P14-15, P15-23,
P16-14
Soylemezoglu, Tulin
P25-03
Söylemezoglu, Tülin
P10-06, P10-07,
P10-08, P08-36,
P13-03, P14-05,
P14-14, P14-15,
P15-23, P16-08,
P16-14, P25-11,
P25-12
Spence, Fiona
P13-21
Spezia, François
P19-08
Spiekstra, Sander
P11-02
Spjuth, Linda
P18-23
Spratt, Maureen
P12-03
Spronck, Lisa
P01-03, P01-04,
P19-05
Srisala, Supanart
P03-12
St Pierre, Liam
P16-07
Stahlmann, Ralf
P05-18
Stampfl, Melinda
P12-86
Starke, Richard
P12-84
Starkey-Lewis, Philip
W13-1, W13-3
Stawiarska-Pieta, Barbara
P04-11, P08-53
Steger-Hartmann, Thomas
S12-3
Steigerwalt, Ronald
W06-3
P01-05
P08-40
W16-2
P12-66
P13-08
W15-2
P07-02
P22-05
P09-18
P07-03
P03-10
P04-10
W10-3, W13-1
P10-19
P09-01, P17-07,
P17-18, P23-10
P12-62
P12-26, P19-12
S15-2, S16-4
P16-05
P19-03
P24-10
P24-01
P03-10
P08-47
P08-13
P24-02
P23-08
P15-20
P10-11
P24-23
S01-3
P02-22
P12-25
P03-06
P18-22
T
Taalab, Yasmeen
P07-32
Tachiki, Hidehisa
P16-06
Tagliati, Carlos
P12-08, P13-05,
P20-37
Tailhardat, Magalie
P18-09
Takahashi, Masayuki
P15-06
Takano, Hirohisa
P11-05, P25-15
Takawale, Pradeep
P25-06
Takezawa, Toshiaki
P12-89, P11-08,
P15-03, P15-04
Tamaki, Toshiaki
P08-13
Tami, Cecilia
S06-1
Taner, Gökçe
P10-01, P10-15,
P10-16, P12-19
Tang, Huan
P24-20
Tani, Niina
P14-24
Tapia, Maria Ofelia
P09-25
Taquahashi, Yuhji
P16-11
Taslak, Hatice
P16-14
Tassone, Paola
P24-18
Tate, Rothwelle J
P04-05
Tavcar, Robert
P15-01
Tavladaki, Georgia
P17-13
Taxvig, Camilla
P12-15, P21-01,
P17-09
Taylor, Ian
P18-26
Taylor, James S
P06-04
Taysse, Laurent
P25-23
Teasdale, Andrew
S09-4, P25-27
Teixeira, João Paulo
P02-08
Teixeira, Mariana
P12-21
Teles, Alessandra
P15-17
Tencalla, Francesca
P20-34, P18-18
Terranova, R
W10-3, W13-1
Terry, Claire
P18-01, P18-02
Teschke, Rolf
P20-27
Testai, Emanuela
S03-1, S03-3
Teubner, Wera
P18-03, P18-04
Teunis, Marc
P11-02, P15-24,
P19-13
Tezuka, Masakatsu
P24-11
Thannimalay, Letchumi
P20-01
Theil, D
W13-1
Theobald, Anne
P20-12
Theodoropoulou, Eleftheria
P07-19, P14-17
Theunissen, Peter
P19-13
Thomas, Luc
P04-04
Thompson, Karol
W13-5, P02-16
Thomson, J
W10-3
Thuilliez, Céline
P19-16
Thünemann, Andreas
P24-19
Tielen, Frans
P11-04
Tiilikkala, Kari
P17-14
Tjalkens, Ronald
S18-4
Tlaskalova-Hogenova, Helena
P14-19
Tluczkiewicz, Inga
P20-38
Togawa, Masako
P25-16
Tokgoz, Orhan
P25-04
Tolosa, Josefa
P09-16
Tomasi, Giorgio
P16-02
Toner, Frank
P20-02
Tonk, Elisa CM
S11-2, W14-3
Topinka, Jan
P03-06, P03-09,
P12-25
Totty, M.
P12-39
Tournaye, Herman
P19-04
Toutain, Pierre-Louis
P19-01
Traebert, Martin
W06-2
Trendelenburg, Christian
W06-2
Tranfo, Giovanna
P02-02, P20-07
Trantakis, Ioannis
P24-10
Tripathi, Ashok K
P17-08
Tritscher, Angelika
S05-5
Troeller, Silke
P12-04, P15-12
Tropsha, Alexander
W16-5
Truisi, Germaine L
P12-56
Truong, Thoa
P12-58
Tsakiris, Ioannis
P09-01, P17-12,
P17-13
Tsakovska, Ivanka
P05-05, P05-06,
P05-16, P05-23
Posters
Steinbach, Christoph
Steiner, Konstanze
Steinmetz, F
Steinritz, Dirk
Stenius, Ulla
Stephan-Gueldner, Markus
Stéphanie, Boudon
Sternberg, Jan
Stevens, Christian
Stevens, Zachary
Stiborova, Marie
Stieger, Bruno
Stiehl, D
Stintzing, Florian
Stivaktakis, Polychronis
Stöber, Regina
Stoppini, Luc
Strauss, Volker
Strigun, Alexander
Ströbel, Simon
Sturla, Shana
Suarez-Merino, Blanca
Sulc, Miroslav
Sulova, Zdena
Summers, Fiona
Sun, Zhi-Wei
Sun, Zu-yue
Sung- Hoon, Ahn
Sungur, Mehmet
Suppi, Sandra
Sutter, Andreas
Suzen, Sinan H
Svecova, Vlasta
Svobodova, Jana
Szewczyk, Aleksandra
145
Tsarouhas, Konstantinos
Tsatsakis, Aristidis
Tsitoglou, Kyriakos
Tsitsimpikou, Christina
Tsuboy, Marcela
Tsuchiya, Hironori
Tsuda, Hiroyuki
Tsujimura, Noriyuki
Tsunoda, Shin-ichi
Tsutsumi, Hideki
Tsutsumi, Yasuo
Tuncer, A.Murat
Tunctan, Bahar
Turek, Claudia
Türksoy, Vugar Ali
Tutkun, Engin
Twisk, Jaap
Tyndale, Rachel
Tzardi, Maria
Tzatzarakis, Manolis
P23-10
W02-1, P02-14, P06-01,
P07-13, P07-19, P09-01,
P14-17, P17-07,
P17-12, P17-13,
P17-18, P23-10
P06-01
P02-14, P07-19,
P17-07, P23-10
P10-05
P07-26
S02-5
P15-06
P14-28
P03-13
S02-5, P14-28
P02-15
P08-15
P10-19
P08-36, P14-14,
P25-11, P25-12
P10-08, P08-35, P25-11
P01-04
P14-24
P23-10
P06-01, P07-13,
P07-19, P09-01,
P14-17,P17-12, P17-18
U
Uang, Shi-nian
Uchino, Tadashi
Uji, Miyuki
Ukairo, Okechukwu
Ulukaya, Engin
Ulicny, Boris
Unlusayin, Irfan
Unterberger, E
Unzu, Carmen
Urani, Chiara
Urano, Koji
Urban, Laszlo
Urbaszek, Piotr
Ursini, Cinzia L.
Ustundag, Aylin
Uteng, Marianne
Uter, Wolfgang
Uysal, Cem
P02-09
P11-08
P14-28
P04-14
P03-14
P07-30
P08-15
W10-3, W13-1
P01-03
P24-08
P03-13
S14-2
P24-24
P02-02, P24-18
P12-69
P12-13, P12-20
W17-3
P25-04
V
Vaccari, Monica
Vacchi-Suzzi, C
Vadillo-Ortega, Felipe
Vahabzadeh, Maryam
Vakonaki, Elena
Valdivia-Flores, Arturo
Valente, Angelica
146
P12-17
W13-1
P08-32
P07-23
P07-13, P07-19,
P14-17, P17-07
P02-07
P14-17
Valentin, Jean-Pierre
S14-3, S14-5, P22-04
Valzacchi, Sandro
P09-12
van Bilsen, JHM
P09-23
van Broekhoven, Sarah
P09-09
van de Water, Bob
P10-03, P12-02
van Delft, Joost
P10-20, P12-02,
P12-45
van der Bijl, Henk
P12-63
Van der Valk, Jan
P15-24
van Goethem, F
W11-4
Van Gompel, J
W11-4
van Hoffen, Els
P09-09
Van Larebeke, Nicolas
P19-04
van Loveren, Henk
S11-2, W01-1, W14-3, P11-11
van Mierlo, Geertje
P11-04
van Nimwegen, E
W10-3
van Oorschot, Arie
P01-04
van Ravenzwaay, Bennard
S15-2, S16-4, P15-14, P16-05, P18-03,
P18-04, P19-14,
P23-13
van Vugt, Harmke
P25-01
van Vugt-Lussenburg, Barbara P12-15
Vandebriel, Rob
P15-24
Vanhecke, Dimitri
P12-29
Vargas, Hugo
P22-04
Vasconcelos, Vitor M
P08-17
Vasilaki, Fotini
P17-07, P23-10
Vavrova, Aneta
P18-24
Vazquez-Lopez, Ines
P08-32
Vecchio, Sarah
P04-01, P04-03,
P04-02
Vedani, Angelo
W16-4
Vega, Elizabeth
P08-32
Velisek, Josef
P01-05
Venancio, Vinicius Paula
P10-14
Vergauwen, Lucia
P08-20
Verhé, Roland
P09-18
Verhoeckx, Kitty
P09-09
Verma, Nitin
P25-17, P25-18
Vermeulen, Nico PE
S17-3
Verstraelen, Sandra
P08-20
Verwei, M
W04-3
Vianello, Giorgio
W02-3
Vicart, Axel
P12-61
Vidry, Stephane
P05-06
Vieira, Andrea
P13-05, P20-37
Vieira, Rafael
P13-05
Vignand, Philippe
P15-26
Viguié, Catherine
P19-01
Vilas-Boas, Vânia
P14-18
Villalba-Benito, Leticia
P09-24
Villeneuve, Daniel L.
P08-20
Viluksela, Matti
P08-11
Vincenti, Marco
P02-21
Vinggaard, Anne Marie
P12-15, P21-01,
P17-09
Vinken, Mathieu
W07-1
Visetpanit, Yupin
P03-12
W
Wagemaker, Tais
P21-03
Wagner, Sandra
P12-75, P16-13
Waisman, Ari
P03-07
Walk, Tilmann
S16-4, P16-05
Walker Junker, Ursula
P13-21
Walker, Paul
P12-18, P12-55,
P12-75
Wallace, Heather M
W09-2
Walles, Heike
P12-10
Wananukul, Winai
P02-03
Wang, Haifang
P24-20
Wang, Haishan
P23-02
Wang, Hui-Min
P07-01
Wang, Liming
S02-2
Wang, Xiaobo
P12-86
Wang, Xingang
P23-02
Wang, Ying-Jan
P08-55
Warren, Simon
P18-20
Watanabe, Wataru
P11-15
Watts, Chris
S15-3
Watzinger, Malene
P03-03
Weaver, Richard J
W06-5
Weber, Klaus
P02-06
Webley, Lisa
P18-26
Wedebye, Eva Bay
P05-14
Wehrli, Bernhard
P24-27
Weidmann, Katharina
P15-07, P25-06
Weidolf, Lars
Weinbauer, Gerhad F
Weisensee, Dirk
Weiser, Thomas
Weiss, Dieter G
Weisschu, Timo
Werner, Inge
Wesolek, Nathalie
Wess, Ralf Arno
Westerholm, Emma
Wheate, Nial
Whiteley, Christopher
Wichers, Harry
Wick, Peter
Wiegand, Rolly
Wielette, Elizabeth
Wiemer, J
Wilks, Martin F
Willard, James
Williams, Faith M
Williams, Philip
Win-Shwe, Tin-Tin
Winter, Matthew J
Wisialowski, Todd
Witters, Hilda
Woitkowiak, Claudia
Wolf, Armin
Wolterbeek, André
Wong, Victor
Woodhouse, Heather
Worth, Andrew
Woutersen, Ruud
Wright, Jayne
Wroblova, Katerina
Wrzesinski, Krzysztof
Wu, Chih-Hsiung
Wu, Jianyao
Wu, Pei-Rung
Wu, Weija
Wuillemin, Natascha
Würtzen, G
Wyszynska, Magdalena
P14-25
W15-4
P16-13
S01-1, P23-02
S03-1
P23-13
S12-2, W18-2
P20-17
P08-39
P20-35
P07-16
P24-14
P09-09
P12-29, P24-26
P13-12
S04-2
S16-4
S12-1, S12-4
P22-04
W04-3
P11-09
P24-04, P25-15
W11-3
P22-04
W11-1, P08-20,
P12-57, P24-07
P19-14
S03-1, P12-13, P12-20, P12-61, P13-21
W11-4, P07-33
P10-18
P12-18, P12-75
W04-2, P05-07,
P05-06, P05-12,
P05-13, P05-16,
P05-23, P18-04
P15-24
P13-12
P07-30
P12-51
P08-55
P20-35
P03-04
P24-09
P13-11, P20-21
W04-5
P08-53
X
Xhau, Kong-Nan
Xie, Luke
Xu, Li
Xu, Xiao
Xu, Yingying
P16-07
W15-1
P23-08
P12-86
P24-20
Y
Yalin, Serap
Yamada, Jun
P10-11
P05-10
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Posters
Vitcheva, Vessela
W04-2, P05-05,
P05-06, P05-23
Vitry, V
W10-3
Vitula, Frantisek
P08-12
Vlachou, Maria
P09-01
Vlckova, Stepanka
P02-12
Vögele, Peter
P10-19
Vojtech, Adam
P08-12
Vojtisek-Lom, Michal
P12-25
Volders, Paul GA
S14-4
Volger, Oscar L
W01-1, P11-11
Vollmer, Günther
P19-14
Volmer, Dietrich
P08-33
Volz, Nadine
P18-06
von Mandach, Ursula
P24-26
von Moos, Lea
P24-10
Vondrácek, Jan
P03-06, P03-09,
P03-11
Vonteru, Kavitha
P08-04
Vorkamp, Katrin
P08-59
Voronina, Alla
P13-10, P13-18,
P19-07
Vrbova, Martina
P07-04
Vrieling, Harry
P10-03, P24-21
Vrzal, Radim
P07-08, P18-24
Vucinic, Slavica
P20-13
Vulic, Ana
P23-05
Vuorinen, Anna
P05-20
Vynias, Dionisios
P17-12
Vynias, Dionisis
P17-18
As a global pharmaceutical company, AstraZeneca­
has a key contribution to make by providing medicines for some of the world’s most devastating
diseases. Come and hear our AstraZeneca scientists
presenting their work here in Interlaken:
Sept 1st: 15:00 Tommy Anderson, ‘Human 3D tissue
cultures to assess metabolism of drugs’
Sept 2nd: 13:55 Guy Healing ‘Practical aspects of
performing carcinogenicity studies’; 14:45 Magnus
Söderberg, ‘Renal Toxicity in Drug Attrition’; 16:00
Sally Robinson ‘Strategies in Preclinical Safety’,
Sept 3rd: 10:00 Peter Newham, ‘Modifying the riskbenefit ratio using drug delivery’; 10:25 Mark Pinches, ‘Classical, qualified and exploratory renal biomarkers’; 11:15 Ruth Roberts, ‘Genetic Susceptibility:
relevance to ADRs; 17:40 JP Valentin, ‘Translational
cardiovascular safety’.
Together we can make a meaningful difference to
the lives of patients now and in the future, because
Health Connects Us All.
The Nestlé Research Center (NRC) in Lausanne,
Switzerland, a centre of fundamental scientific
research and innovation within Nestlé. We drive
science and technology, from basic nutrition and
health research, to applied research for product
development and application, to ensuring the
utmost quality and safety of Nestlé products. The
scientific excellence and technical knowledge of
Nestlé Research helps fulfill Nestlé’s vision of
Good Food, Good Life for all consumers.
To learn more about the Nestlé Research Center
and our research activities, visit:
www.research.nestle.com.
BASF SE – Experimental Toxicology and Ecology
Established in 1986, ILSI Europe fosters collaboration among the
best scientists to provide evidence-based scientific consensus in the
areas of nutrition, food safety, toxicology, risk assessment, and the
environment.
By facilitating their collaboration, ILSI Europe helps scientists from many
sectors of society – public and private – to best address complex science
and health issues by sharing their unique knowledge and perspectives.
ILSI Europe advances the understanding and resolution of scientific issues
through expert groups, workshops, symposia and resulting publications.
The ultimate goal of ILSI Europe is the improvement of public health.
www.ilsi.eu
148
BASF experimental toxicology and ecology with
decades of experience offers a complete range of
regulatory studies in the field of toxicology and
ecology in accordance with the most stringent
standards demanded by authorities globally.
The studies are conducted in AAALAC certified
laboratories in compliance with OECD, EC, EPA,
MHLW/METI, J/MAFF, FDA guidelines, current animal protection regulations, and Good Laboratory
Practice (GLP), with a clear commitment to quality
and continuous improvement. Since more than 20
years BASF’s experimental toxicology and Ecology
actively promotes and develops alternative methods for toxicological testing according to the 3R’s
principle.
Yüksel, Bayram
Yun, Hyo-In
Yun, James
Yuta, Kohtaro
Yuta, Kohtaro
P25-11
P25-24
P20-21
P05-21
P05-09
Z
Zacarias, Cyro
P15-29
Zaki, Hala
P25-02
Zaldivar Comenges, José Manuel P05-12, P05-13
Zalejska-Fiolka, Jolanta
P04-11, P08-53
Zaugg, Daniela
P18-16
Zeneli, Lulzim
P02-04, P08-34
Zetterberg, Charlotta
P18-15
Zhang, Xiao-kun
S18-3
Zhang, Xiaoyu
P22-01
Zhao, Bin
P14-24
Zhao, Hui
P24-12
Zhitkovich, Anatoly
P10-18
Zhou, Haojin
P05-02
Zhou, Shaoying
P20-02
Zhou, Zhou
P12-53
Zhu, Zheying
P16-09
Zierau, Oliver
P19-14
Zilliacus, Johanna
P20-23
Zimmermann, Michael
P24-10
Zlabek, Vladimir
P01-05, P12-76
Zuang, Valérie
P18-09
Zufferey, Fanny
P12-83
Zürich, Marie-G
S03-1
Posters
Yamada, Takashi
P05-10
Yamaguchi, Hiroyuki
P12-89
Yamaguchi, Manami
P14-28
Yamashita, Kunihiko
P11-08
Yanagisawa, Rie
P11-05, P25-15
Yang, Chihae
W04-2, W04-3,
P05-02, P05-05,
P05-07, P05-06,
P05-08, P05-23
Yang, Jian-yan
P23-08
Yang, Raymond SH
W09-4
Yang, Xing
P24-12
Yassin, Nemat
P23-11
Yasuda, Satoshi
P03-13
Yavas, Guler
P07-10
Yavuz, Oguzhan
P09-12
Yerly, Daniel
P13-11, P20-21
Yildiz, Ferah
P07-10
Yildiz, Oguzhan
P07-09, P07-10,
P07-11
Yilmaz, Hinc
P08-35, P25-12
Yilmaz, Veysel T.
P03-14
Yilmazer, Meltem
P02-22
Yonekura, Kazuhiko
P23-09
Yoshida, Hiroki
P11-15
Yoshimi, Shimizu
P24-11
Yoshino, Tomoko
P15-06
Yoshioka, Yasuo
S02-5, P14-28
Young, Robert
P10-17
Yousef, Mokhtar Ibrahim
P19-17
Yu, Ho-Sung
P25-24
Yu, Yongbo
P24-02
Yu, Zhengping
P12-53
Yuen, Peter
W13-5, P02-16
149
SWISS – the airline of Switzerland
Swiss International Air Lines serves 74 destinations in 38 countries
all over the world from its Zurich hub and the further Swiss international airports of Basel and Geneva with a fleet of 92 aircraft.
As the airline of Switzerland, SWISS is a byword for traditional Swiss
values. True to its roots, the company is dedicated to providing the
highest possible quality in all its products and services. With its
manageable medium size, SWISS is also optimally equipped to remain as close as possible to its customers and meet their individual
needs. As part of the Lufthansa Group and a member of Star Alliance, SWISS remains true to its mission of providing quality air services that link Switzerland with Europe and the world.
SWISS understands the full depth and breadth of its customers’
requirements, whether it is the luxury of a long-haul flight in SWISS
First, for business travellers the comfort and peace of SWISS Business or simply the friendliness of the service provided in SWISS
Economy. No matter which of these you book, you can be sure of
receiving just the kind of personalized service of which we are so
proud. We are committed to taking care of your needs from the
moment you book your flight right up to your arrival at your destination.
As the official carrier to 49th EUROTOX Congress in Interlaken, Swiss
International Air Lines wishes all participants a fruitful meeting and
a pleasant stay in Interlaken.
150
Exhibitors & Exhibitors Booth Map
Booth 1: Eurotox 2014
The 50th Congress of the European Societies of Toxicology will be held at the
Edinburgh International Conference Centre, Edinburgh from the 7th to the 10th
September 2014. The organising committee is pleased to announce an exciting
innovative congress, with sound scientific presentations covering a wide range
of topics representing the latest scientific and regulatory development.
Contact: Colette Bowditch
4 – 6 Oak Lane, Edinburgh EH12 6XH
Scotland
E-Mail: [email protected]
Web:www.eurotox2014.com
Booth 2: Bioagri
Bioagri – a Mérieux NutriSciences Company – is the largest and the most complete
private group of analytical laboratories in Latin America, with 16 units distributed
in 10 states in Brazil. Being the leading CRO offers high quality analysis to the
agrochemical, chemical, cosmetic, food and pharmaceutical industries. Services
encompass physico-chemical, toxicological (Acute, Chronic, Repro-Tox and In-Vivo/
In-Vitro), analytical and microbiological studies, ecotoxicity, five-batch and residues
analysis under applicable regulatory guidelines. Located in Brazil, BIOAGRI labs are
GLP-certified since 2002, ISO 17025, accredited by AAALAC and employ the most
current equipment and technologies.
Exhibitors &
maps
Contact: Dr. Jean-Luc GARRIGUE, MD, PhD, EUROTOX Toxicologist
Director Scientific Affairs Europe
Phone: +33 (0)437 418 336
Mobile: +33 (0)607 493 701
Fax: +33 (0)472 590 038
E-Mail: [email protected]
Web:
www.bioagri.com.br, www.merieuxnutrisciences.com
151
Booth 3: B‘SYS
As a contract research organization B‘SYS provides assistance to pharmaceutical
settings in Ion Channel Discovery. Biological Monitoring Systems offers ion channel
services (QPatch automated and manual patch clamping, including Dynaflow and
RSC, Fluorescence assays using Flexstation/FLIPR) for determination of biophysics,
mechanism, screening services, and expression stability studies. Ion channel cell
line design and FACS sorting services support the activities.
The company based in Switzerland focuses on the fast screening of new substances
on ion channel drug targets. B’SYS is a GLP compliant facility and equipped with
state of the art devices for test item analysis.
Contact: Dr. Daniel Konrad, CEO
Phone: +41 61 721 77 44
Mobile: +41 79 348 45 04
E-Mail: [email protected]
Web:www.bsys.ch
Booth 4: Cultex Laboratories
In the field of inhalation toxicology Cultex Laboratories is the platform for the
in-vitro analysis of airborne substances, such as particles, gases, volatile compounds
and complex gas mixtures under realistic atmospheric conditions. We developed
a wide range of exposure systems, like the CULTEX® RFS, for the direct exposure
of cultivated cells to test atmospheres. We accept R&D contracts from the industrial and public sector. Our consulting services support project planning and implementation.
Contact: Prof. Dr. rer. nat. Michaela Aufderheide
Feodor-Lynen-Strasse 21
30625 Hannover
Germany
Phone: +49 511 563586-0
E-Mail: [email protected]
Web:www.cultex-laboratories.com
152
Booth 5: Lhasa
Lhasa Limited is an educational charity and leading supplier of in silico knowledge
based software and databases including;
• Derek Nexus: For predicting toxicity
• Meteor: For predicting metabolic fate
• Zeneth: For predicting chemical degradation pathways
• Vitic Nexus: Toxicity database and management system
Lhasa Limited is an active research organisation with an enviable reputation for
collaborative work and the promotion of data sharing. We work closely with our
members in the research and development of software for the chemical and
bio-molecular sciences. Members include the world’s top 20 pharmaceutical
companies, leading consumer products manufacturers, academics, regulatory
bodies and government organisations.
Phone: +44 (0)113 394 6020
E-Mail: [email protected]
Web:www.lhasalimited.org
Booth 6: Bucher Biotec/ACEA Biosciences
Contact: Bucher Biotec AG
Viaduktstrasse 42
4051 Basel
Switzerland
Phone: +41 61 269 1111
E-Mail: [email protected]
Web: www.bucher.ch
ACEA Biosciences launched its first product for real-time, label-free cell-based
assays based on a microelectronic readout in 2004. Today, the company has a
portfolio of six instruments which utilize this technology with different functional-
153
Exhibitors &
maps
Bucher Biotec AG is a privately held Swiss distributor company representing some
of the most advanced US and European manufacturers of highly innovative life
science research instrumentation, associated reagents and consumables. We are
extremely proud of our distinguished customer base in the pharmaceutical,
biotechnology, agricultural, food and related industries, in all life science research
oriented academic institutions, in numerous governmental, clinical and environmental labs and in all of the university hospitals. Our highly competent, well
educated team is focused on understanding our customer’s needs in order to be
able to propose optimal solutions for the demanding research tasks, and in order
to help to accelerate scientific exploration.
ities and throughputs, enabling different types of cell-based applications. The
application range is broad and diverse, covering all aspects of pre-clinical drug
discovery and development as well as toxicity and safety pharmacology.
The instruments are well utilized in basic academic research. The citation of the
systems in over 400 peer reviewed publications from the pharmaceutical industry
and academia is a testament to the success and uptake of this platform.
Web: www.aceabio.com
Booth 7: Huntingdon Life Sciences
Huntingdon Life Sciences, an international Contract Research Organisation offers
a comprehensive range of development services to pharmaceutical and biopharmaceutical companies around the world.
Our world renowned scientific, technical, and regulatory experts have the breadth
and depth of experience to ensure you deliver your R&D milestones. We set the
highest standards and offer a broad range of practical support, consultancy and
problem solving, all of which can be tailored to meet your specific needs.
We are committed to providing you with a customised service, from outsourced
single studies, through management of complex programmes, to the development
of long-term strategic partnerships.
E-Mail:[email protected]
Web:www.huntingdon.com
Booth 8: Cellular Dynamics
Cellular Dynamics International is a leading developer of fully functional human
cells derived from induced pluripotent stem (iPS) cells. Our iCell® and MyCell®
product lines provide industrial quantities of high quality, highly pure human
cells enabling disease modeling, drug discovery, toxicity testing, and regenerative
medicine research.
Contact: Media Relations
Joleen Rau, Senior Director of Marketing & Communication
Phone: +1 608 310-5142
Web: www.cellulardynamics.com
154
Booth 9: Instech Solomon
Instech Solomon is a leader in laboratory animal infusion and sampling, with a focus
on products that improve operational efficiency and adherence to the 3Rs.
• PinPort™ streamlines access to externalized catheters
• Plastic feeding tubes minimize trauma during oral gavage
• Vascular Access Harnesses™ simplify the connection of tethered mice and rats
• ABS2™ automates the collection of blood samples from mice, rats and large
animals
• Orchesta™ pump software automates large GLP infusion studies.
Contact: Edwin N. Spoelstra, M.Sc.
Instech Solomon
PO Box 2
9950 AA Winsum
The Netherlands
Phone: +31 (0)594 769026
Mobile: +31 (0)6 81294900
Fax: +1 610 941 0134
E-Mail: [email protected]
Web: www.instechlabs.com
Booth 10: InSphero/Cyprotex
Contact: InSphero AG
Wagistrasse 27
8952 Schlieren
Switzerland
Phone: +41 (0)44 515 04 90
E-Mail:[email protected]
Web: www.insphero.com
Cyprotex, an AIM-listed company (CRX), was founded in 1999 and specialises in
ADME-Tox. We have facilities in the UK and the US. As well as offering routine and
customised physicochemical, ADME and toxicity screening services, Cyprotex has
in silico QSAR and PBPK modelling expertise. We have developed several novel
technologies including CellCiphr® Premier for prediction of hepatotoxicity,
eCiphrCardio for prediction of cardiotoxicity and Cloe® PK for estimating whole-
155
Exhibitors &
maps
InSphero 3D InSight™ Liver Microtissues enable more biologically relevant in vitro
testing of lead compounds, including long-term and inflammation-mediated toxicity. The portfolio currently comprises rat and human liver microtissues, with additional models in the pipeline. InSphero’s robust and consistent 3D microtissues
meet the exacting needs and high expectations of today’s pharmaceutical, cosmetics and chemical industry. InSphero is certified to the ISO 9001:2008 standard.
body exposure using PBPK modelling. Cyprotex’s services take a consultative,
collaborative approach that includes custom assay development and high quality
data generation and interpretation.
Contact: Dr. Bodo Spoeri, MBA, Executive Director, Business Development
Cyprotex Discovery Limited
15 Beech Lane
Macclesfield, Cheshire, SK10 2DR
United Kingdom
Phone: +44 (0)7502 40 90 10
Fax: +44 (0)1625 50 51 99
E-Mail: [email protected]
Web: www.cyprotex.com
Booth 11: Bertin Pharma/Chemie Brunschwig
Bertin Pharma is a French company that:
• develops, manufactures and distributes a wide and unique range of bioreagents
(pre-analytical products, assays, antibodies and biochemicals) for various therapeutic areas such as inflammation diseases, endocrinology, diabetes, obesity,
hypertension, psychopharmacology, cancer, asthma, prion diseases, etc. and in
the fields of pharmacokinetic, metabolism e.g. SPI-Bio – MS2Plex assays and toxicology, and
• is a global R&D service provider throughout the whole drug development process:
Pre-clinical & clinical including ADME-T, Biosafety, Pharmaceutical development &
clinical supplies thanks to adequate quality standard environments (GLP, GMP, GDP).
E-Mail: [email protected]
Web: www.bertinpharma.com
Since its foundation in 1948, Chemie Brunschwig AG has specialised in Switzerland
in promoting and marketing more than 700,000 products to laboratories for R&D,
analysis and production.
Our product range is based in three main areas: chemistry, life sciences and labware.
Chemie Brunschwig your partner for:
• Organic Chemistry • Biochemistry
• Inorganic Chemistry
• Molecular Biology
• Analytical Chemistry
• Cell Biology
• Chromatography
• Microbiology
• Liquid Scintillation
• Histology/Cytology/IHC
Our business consists of giving to Swiss customers the benefit of our expertise and
service by offering them products that are adapted to their needs, and sourced
from many different manufacturers from all over the world.
E-Mail: [email protected]
Web: www.brunschwig-ch.com
156
Booth 12: MicroMatrices Associates
MicroMatrices Associates deliver preclinical and research solutions for mechanismbased risk assessment and mode of action studies.
Services include: histopathology evaluation, imaging, laser dissection; biomarker
identification; genomics/pathways analysis; scientific interpretation; manuscript/
formal report preparation.
MicroMatrices have a unique methodology for analyzing archival FFPE tissue blocks
for mechanistic toxicity endpoints, allowing for retrospective cell-type specific risk
assessment.
MicroMatrices are also developing CellMatricesTM, a highly adaptable human-relevant in vitro testing system, based upon nanowire biosensor detector technology.
We work with clients on an interactive basis, starting with pilot projects, which are
scalable or can form the basis of larger research programs.
Contact: Simon Plummer, Managing Director
MicroMatrices Associates Ltd
Dundee University Incubator
James Lindsay Place
Dundee DD1 5JJ
United Kingdom
Phone: +44 1382 322909
Web: www.micromatrices.com
Booth 13: Philips
Designed around the needs of pathologists, Philips offers an integrated Digital
Pathology Solution. The solution comprises of the Philips Ultra Fast Scanner (UFS)
and Image Management System (IMS). The UFS is easy to use and creates whole
slide images of exceptional quality in less than 60 seconds per slide (40x equivalent,
15 x 15 mm scan area). The IMS is designed for speed and ease of use: supports
fast and efficient workflow with bi-directional integration of the Laboratory Information System. Visit us and learn more about powerful sharing tools that allow
real-time collaboration with colleagues anywhere in the world.
Exhibitors &
maps
Contact: Dr. Christian Tank, Director Sales
Digital Pathology Solutions DACH
Philips GmbH, Unternehmensbereich Digital Pathology
Lübeckertordamm 5
20099 Hamburg
Germany
Phone: +49 1525 7966778
Web: www.philips.com/digitalpathology
157
Booth 14: EPL Archives
EPL Archives, a globally recognized leader in the research archiving and biorepository field for more than three decades, provides secure GLP, GCP and GMP (collectively GxP) storage for research materials.
Our services include packaging, transportation, inventory, and specialized archival
of wet tissue, blocks, slides, paper, electronic media, test articles & samples.
Standard and custom environments are available including Controlled Room
Temperature, refrigerated, frozen and cryogenic. Specialized conditions for paper
storage are also offered. The facility and staff are certified to handle radioactive
and controlled substances. Rapid retrieval and Scan-On-Demand services ensure
client materials are available when needed.
EPL Archives’ facilities located in Sterling, VA and Nice, France, provide in excess
of 1 000 000 cubic feet of secure space, as well as the capacity to archive several
hundred cryo freezers.
Phone: +1 703 435-8780
E-Mail: [email protected]
Web: www.eplarchives.com
Booth 15: European Food Safety Authority (EFSA)
EFSA is the keystone of European Union (EU) risk assessment regarding food and
feed safety. In close collaboration with national authorities and in open consultation with its stakeholders, EFSA provides independent scientific advice and clear
communication on existing and emerging risks.
EFSA was set up in January 2002, following a series of food crises in the late 1990s.
EFSA’s independent scientific advice underpins the European food safety system.
Thanks to this system, European consumers are among the best protected and best
informed in the world as regards risks in the food chain.
Web: www.efsa.europa.eu
Booth 16: EBSCO
Expert Publishing (ExPub) is the world’s leading provider of up-to-date toxicology
and chemical hazard information. ExPub databases provide access to millions of
documents containing comprehensive human and/or environmental hazard data
needed to manage the impact of chemicals in the workplace or on the environment.
ExPub consists of more than 150 databases with access to millions of documents
from government and licensed sources. It covers approximately 410,000 unique
substances and accessible via more than 2.4 million chemical names and synonyms.
Databases include: ChemEXPERT™, ReproEXPERT™, ListEXPERT™, DrugEXPERT™
and MSDSonline®.
Web: 158
www.ebsco.com
Booth 17: ADR-AC
ADR-AC GmbH is a spin-off company of the University of Bern, Switzerland, focusing on drug hypersensitivity research, diagnosis and consulting. It is based on the
extensive laboratory and clinical experience of its scientific director, Prof. Werner J.
Pichler. ADR-AC offers pharmaceutical companies clinical and experimental expertise on allergic/immune mediated reactions to small drugs and biologicals. For diagnosis of drug hypersensitivity in e.g. phase III studies, ADR-AC offers its clinical expertise and combines a multitude of tests to pinpoint the relevant drug. For risk
assessment of drugs in development, ADR-AC has established systems to evaluate
the immune stimulatory potential of drugs.
Contact: ADR-AC GmbH
Holligenstr. 91
3008 Bern
Switzerland
E-Mail: [email protected]
[email protected]
Web: www.adr-ac.ch
Booth 18: Comet BioTech
Comet BioTech (CBT) was founded in 2010, and is based on the core research by
some of its leading scientists; Maria Dusinska, Gunnar Brunborg and Andrew
Collins.
CBT provides the latest, state-of-the-art, high throughput assays targeted at the
chemical industry, food safety, cosmetic and pharmaceutical companies, regulatory
bodies, the REACH programme, basic genome research and biomonitoring projects.
While the core interest of the company is the comet assay, we also offer a range of
genotoxicity and cytotoxicity assays (e.g. Ames, micronucleus, chromosome aberration, mutation assay), as well as new methods development, expertise, consulting
and training.
Exhibitors &
maps
Contact: Comet BioTech
PO Box 100
2027 Kjeller
Norway
E-Mail: [email protected]
Web: www.cometbiotech.com
159
Booth 19: Swiss BioAnalytics/Confarma
Swiss BioAnalytics is a bioanalytical Contract Research Organization based in Basel,
Switzerland, and provides bioanalytical services for the pharmaceutical industry
across all phases of the drug development and registration process. This includes
• pharmacokinetic and toxicokinetic studies in preclinical and clinical trials
• bioanalysis for bioequivalence studies
• metabolite profiling and metabolite identification
• total mass balance studies (ADME)
• identification of impurities, degradation products etc.
The company was founded in 1999 and has conducted much more than 1000 studies, about half of them under GLP. Currently the facility operates 11 HPLC-MS/MS
workplaces, including a high resolution LTQ-Orbitrap.
Contact: Dr. Winfried Wagner-Redeker
Swiss BioAnalytics AG
Sternenfeldstrasse 14
4127 Birsfelden
Switzerland
Phone: +41 61 317 23 90
E-Mail:[email protected]
Web: www.swissbioanalytics.com
CONFARMA is a CRO since 1972, specialized in R&D, CMC and studies.
Activities: Analytical chemistry, Galenics, Stability studies, Microbiology,
­Biochemistry, Biology, Immunology, Molecular Biology, Pharmacology-Toxicology
Phases of development: R&D (contract research), Preclinical, Clinical (only
­analytics), Commercial (CMC)
Markets: Academic Research Institutions, EU collaborative projects, Biotech,
­Biopharma, Vaccines, Pharma, Medical Devices
Certification: GMP, c-GMP (FDA), GLP, ISO9001, ISO14001, ISO17025, OHSAS18001,
FDA registered DUNS number 49-273-8125
• Preclinical studies for safety and efficacy
• Small and large molecules
• In-vitro, ex-vivo and in-vivo platforms
• Pharmacology, Pharmacokinetics, Toxicokinetics, ADME
• Toxicology: acute, sub-acute, sub-chronic, chronic, reproduction
• Hematology, clinical chemistry, Pathology
• Biocompatibility, Genotoxicity, Hemocompatibility
Contact: Ralf Holzinger, Director Science, Sales & Marketing
CONFARMA FRANCE SARL
ZI, rue du canal d’Alsace
68490 Hombourg
France
Phone: +33 389 83 37 20
Fax: +33 389 83 37 29
Mobile: +33 689 51 03 19
E-Mail: [email protected]
Web: www.confarma.eu
160
Booth 20: VITROCELL© Systems
VITROCELL© is specialized in the development of advanced in vitro exposure
systems. VITROCELL© realizes turnkey installations for in vitro inhalation toxicology
in which gases, environmental atmospheres, nanoparticles and complex mixtures
are analyzed on lung cells at the air/liquid interface.
VITROCELL© Skin modules and the VITROCELL© Skin Autosampler are specially
designed for the exposure of tissue.
The customers of VITROCELL Systems GmbH are leading research institutes,
contract research organisations, regulatory authorities as well as the pharmaceutical and other industries throughout the world
Contact: Tobias Krebs
Fabrik Sonntag 3
79183 Waldkirch
Germany
Phone: +49 (0) 7681 497 79 50
E-Mail: [email protected]
Web: www.vitrocell.com
Booth 21: MatTek
MatTek has been a world leader in the field of tissue engineering for the past 20
years. Using state-of-the-art GMP facilities in the USA (Ashland, MA) and EU
(Bratislava, Slovakia), we produce cutting edge 3D reconstructed human tissue
equivalents for the cosmetic, personal care, household product, chemical and pharmaceutical industries. MatTek tissues have been cited in over 700 technical articles
and 300 patents related to product development, toxicology, safety assessment,
claims substantiation and drug discovery. Our tradition of scientific and technological innovation remains strong as we continue to develop and validate new in vitro
assays and human cells based tissue models.
MatTek IVLSL
Mlynské Nivy 73
821 05 Bratislava
Slovakia
+421-2-3280-7401
+421-2-3280-7404
[email protected]
www.mattek.com
Exhibitors &
maps
Contact: MatTek Corporation
200 Homer Ave.
01721 Ashland, MA United States of America
Phone: +1-508-881-6771
Fax: +1-508-879-1532
E-Mail: [email protected]
Web: www.mattek.com
161
Booth 22: Institute of Industrial Organic Chemistry
The Institute of Industrial Organic Chemistry (IPO), Branch Pszczyna is a contract
research organization with more than 65 years of tradition. As a GLP-certified
Institute, it performs a wide variety of toxicological and ecotoxicological studies
of plant protection products, pharmaceutical products, veterinary medicinal products, food and feed additives, industrial chemicals, biocides and industrial wastes.
The Institute is the first in Poland to hold the Statement of GLP Compliance for
all offered tests. The GLP Certificate guarantees that the studies are accepted
worldwide, and their results are of great practical and scientific value.
Contact: Institute of Industrial Organic Chemistry, Branch Pszczyna
Doświadczalna 27
43 – 200 Pszczyna
Poland
Phone: +48 32 210 30 81
Fax: +48 32 210 35 37
E-Mail: [email protected]
Web: www.ipo-pszczyna.pl
Booth 23: BSL BIOSERVICE
Safety and Activity Testing Services – BSL BIOSERVICE, based in Munich, is an internationally recognized Contract Research Organization (CRO) and a member of a
worldwide laboratory network. We have more than 25 years of experience in biological safety and activity testing for Pharmaceuticals, Medical Devices, Chemicals/
REACH, Agrochemicals, Cosmetics and Food.
BSL BIOSERVICE has been certified in accordance with GLP as well as being accredited with DIN EN ISO 17025 for biocompatibility of medical devices. In addition BSL
BIOSERVICE holds a GMP certificate and is listed by the World Health Organization
(WHO) and has also passed two FDA inspections successfully.
Contact: BSL BIOSERVICE Scientific Laboratories GmbH
Behringstraße 6/8
82152 Planegg/Munich
Germany
Phone: +49 89 89 96 50-0
Fax: +49 89 89 96 50-11
E-Mail: [email protected]
Web: www.bioservice.com
162
Booth 24: Medicyte
Medicyte has developed unique and proprietary cell proliferation platforms that
form the basis for novel cell-based research and drug development tools and future
cell therapy products.
upcyte® Hepatocytes are human cell strains which are manipulated into controlled
proliferation, without being immortalized or changing the typical phenotype.
Therefore, upcyte® Hepatocytes are available in virtually unlimited quantities with
a consistently high quality.
upcyte® Hepatocytes – the alternative to conventional ADME/Tox models:
• Proliferating without being immortalized
• Available in virtually unlimited amounts
• Retaining primary donor characteristics
• >90 % attachment efficiency
• Available from multiple donors
• Cytotoxicity qualified
• Genotoxicity qualified
• Express drug transporters
• CYP induction qualified
Exhibitors &
maps
Contact: Marion Dumitraskovic
Medicyte GmbH
Im Neuenheimer Feld 581
69120 Heidelberg
Germany
Phone: +49 6221 72925-34
E-Mail: [email protected]
Web: www.medicyte.com
163
Booth 25/26: WIL Research
WIL Research is a global CRO dedicated to listening to customer needs. We custom
design product safety toxicological research, bioanalytical, & formulation services
for pharmaceutical, biotechnology, chemical, agrochemical, & food companies.
WIL Research also recently acquired Ricerca Biosciences’ pharmaceutical services
business located in Lyon, France. The addition of the 18,000-square meter facility
fortifies WIL Research’s service offerings in Europe, strengthens its nonclinical safety assessment capability, and expands its portfolio of innovative specialty services
Over the past 45 years, the Lyon facility has developed a strong scientific reputation
with European pharmaceutical clients in safety pharmacology and specialized services including continuous infusion and developmental and reproductive toxicology.
With approximately 1,200 staff worldwide and 63,000 square meters of laboratory
space, located throughout the world, WIL Research offers technological expertise,
flexible study design, & quality results.
Contact: WIL Research
1407 George Road
Ashland Ohio, 44805
United States of America
Phone: +1-419-289-8700
Web: www.wilresearch.com
Booth 27: WUXI AppTec
St. Paul, MN and Suzhou, China – WuXi AppTec provides a full-range of in vivo and in
vitro preclinical safety evaluation studies which are part of our integrated portfolio
of drug discovery and development services. By focusing on quality, scientific expertise, flexibility and responsiveness, WuXi partners with our Sponsors to provide
a wide range of IND/NDA enabling toxicology and laboratory services that meet
global regulatory standards. Our services are designed to help our worldwide customers shorten the time and lower the cost of drug and medical device R&D
through cost-effective and efficient outsourcing solutions.
Contact: WuXi AppTec (Suzhou) Co., Ltd.
1318 Wuzhong Avenue
Wuzhong District
Suzhou 215104
China
Phone: +86 (512) 6883-7321
Fax: +86 (512) 6883-7303
Web: www.wuxiapptec.com
164
Booth 28/29: CiToxLAB
CiToxLAB is an international CRO (France, Canada, Denmark and Hungary) that
offers non clinical in vitro and in vivo safety studies. World-wide based pharmaceutical and biotechnology companies take advantage of more than 40 years of experience and experience in toxicology studies in rodents, dogs, primates and minipigs,
inhalation and infusion studies, safety and general pharmacology, genetic toxicology, genomics, reproductive toxicology, immunotoxicology, pathology, juvenile
studies and carcinogenicity testing, along with ADME and bioanalysis. Our facilities
are GLP and AAALAC certified in order to provide full non-clinical development
programs in support of IND and later-stage regulatory submissions. Contact our
experts at www.citoxlab.com.
Web: www.citoxlab.com
Booth 30: CXR Biosciences
CXR Biosciences uses its collaborative approach and toxicological expertise to help
customers of all sizes solve issues relating to the safety of compounds or selection
of drug candidates. CXR Biosciences offers tailored preclinical services in the areas
of investigative toxicology, exploratory & discovery toxicology and drug development. Our customers include leading pharmaceutical, agrochemical, chemical and
biotechnology companies. CXR is located in Dundee, Scotland, United Kingdom.
Exhibitors &
maps
Contact: Carol Ann Sutton, Business Support Manager
CXR Biosciences Ltd
2 James Lindsay Place
Dundee DD1 5JJ
Scotland
Phone: +44 1382 432163
Fax: +44 1382 432153
E-Mail:[email protected]
Web: www.cxrbiosciences.com
165
Booth 31: TierPathologisches Labor Dr. Helmut Laaff
Animal pathology with a clear aim – Dr. Laaff’s AnimalPathology Laboratory is a
privately owned company, active as a histology laboratory for over 20 years; our
partners include surgeons and other practicing physicians, universities and research
institutes. This experience forms the basis of our work in animal pathology, and
we have a clear corporate policy: we offer our clients rapid and efficient service
at reliable conditions.
Dr. Laaff’s AnimalPathology Laboratory is one of the few GLP-certified, privately
owned and managed laboratories in Europe. We can thus offer a quality assurance
system whose excellence is recognized in all OECD countries.
Contact: TierPathologisches Labor Dr. Helmut Laaff
Sasbacher Strasse 10
79111 Freiburg
Germany
Phone: +49 761 120 3626
Fax:
+49 761 120 3615
E-Mail:[email protected]
Web:www.tpl-freiburg.de
Booth 32: Rhenovia Pharma
RhenoviaPharma is a biotechnology company specialized in the development of
innovative solutions to improve the prevention and the treatment of neurodegenerative diseases of the central/peripheral nervous system.
Rhenovia approaches the complexity of biological systems with a unique technology of modeling and simulation of the neuronal communication mechanism, from
molecular/ cellular level up to neuronal network.
If its biosimulation technology primarily applies to the discovery of new medications, it has been oriented towards the toxicological field too regarding the urgent
need for the development of innovative technologies aiming at detecting early
enough the risks for the population to exposure to neurotoxic agents.
Contact: Dr Serge Bischoff, CEO
Rhenovia Pharma
20c rue de Chemnitz
68200 Mulhouse
France
Phone: +33 3 89 32 11 80
Fax:
+33 3 89 55 51 45
Web: www.rhenovia.com
166
Booth 33: Toxi-Coop
Toxi-Coop performs GLP-compliant pre-clinical and regulatory in vivo and in vitro
testing of pharmaceuticals, medical devices, chemicals (REACH), agrochemicals,
cosmetics, biocides, food ingredients/additives. Services include acute, repeated
dose and chronic toxicology, genetic toxicology, ecotoxicology, reproductive toxicology testings in a broad range of species. Our staff has typically 10 or more years
of expertise with the studies. The services fulfill high quality requirements and are
delivered on time at competitive prices. We meet the criterias of expertise, flexibility and timeliness.
Contact: Dr. Josef P. Magyar, Director Global Business Development
Toxi-Coop Research Services, BD
Weltistrasse 11
5000 Aarau
Switzerland
Phone: +41 (0)62 535 535 4
Mobile: +41 (0)79 771 61 96
E-Mail: [email protected]
Web: www.toxicoop.ch
Booth 34/35: Harlan Laboratories
Harlan Laboratories is a global provider of non-clinical contract research, research
models, animal diets, and services to the pharmaceutical, biotech, medical device,
agrochemical and chemical industries, including academic and government organizations. We focus on providing customers with products and services to optimize
the discovery and safety of new medicines and compounds.
Exhibitors &
maps
Contact: Harlan Laboratories Ltd.
Zelgliweg 1
4452 Itingen
Switzerland
Phone: +41 (0)61 975 11 11
Fax:
+41 (0)61 971 52 84
E-Mail: [email protected]
Web: www.harlan.com
167
Booth 36: Myriad RBM
Myriad RBM, Inc. is the world’s leading multiplexed immunoassay testing laboratory, providing comprehensive protein biomarker services based on its Multi-Analyte
Profiling (MAP) technology platform. This platform provides pre-clinical and clinical
researchers with reproducible and quantitative data for a few or hundreds of proteins in a cost-effective manner. To learn more, visit www.myriadrbm.com.
Phone: +1 866 726-6277
E-Mail: [email protected]
Web: www.myriadrbm.com
Booth 37: Enzo Life Sciences
Enzo Life Sciences is a recognized leader in technologies for genomics, cellular
analysis, immunoassays, assay development, proteostasis, epigenetics, and small
molecule chemistry. Our diverse portfolio of fluorescent labels & dyes, ELISA and
enzyme activity assays, biochemicals, antibodies, and proteins serves the life
sciences research, drug development, and clinical research markets. Our products
facilitate discovery in cancer, neuroscience, cellular stress, immunology, toxicology,
bioprocess optimization, screening and lead identification, and clinical diagnostics.
We are scientists enabling scientists™.
Contact: Enzo Life Sciences (ELS) AG
Industriestrasse 17
CH-4415 Lausen
Switzerland
Phone: +41 61 926 89 89
Fax: +41 61 926 89 79
E-Mail: [email protected]
Web: www.enzolifesciences.com
168
Booth 38: Elsevier
Explore Elsevier’s high-impact toxicology journals and books. Learn the latest in
research news from journals such as Toxicology and Toxicology and Applied Pharmacology. Our exciting books on display include A Comprehensive Guide to Toxicology in Preclinical Drug Development, Haschek, Rousseaux’s Handbook of Toxicologic Pathology and Computational Toxicology. Discover our electronic research and
solution tools, ScienceDirect and PharmaPendium.
Contact: Jolanda Grondman-de Rijk, Exhibitions Department
ELSEVIER B.V.
Radarweg 29
1043 NX Amsterdam
The Netherlands
Phone: +31 20 485 3798
Fax: +31 20 485 3228
E-Mail: [email protected]
Web: www.store.elsevier.com
Booth 39: InnoStar
Founded in 1993, Shanghai InnoStar Biotech Co., Ltd (also known as National Shanghai Center for New Drug Safety Evaluation and Research) is a leading preclinical
CRO in China. As the first CFDA- and OECD-certified Chinese GLP lab, we provide a
full spectrum of the preclinical safety evaluation including GLP studies in general
toxicology, genetic toxicology, reproductive & developmental toxicology and safety
pharmacology, early drug screening, toxicity prediction, and regulatory services.
We have successfully submitted safety studies and IND packages to both CFDA and
US FDA and have evaluated over 400 drug candidates to date (348 small molecules,
62 biologics and 18 herbs).
Exhibitors &
maps
Contact: Joanne Jiang, Marketing/Project Manager
Phone: +86 21-5080-0333, ext. 117
E-Mail: [email protected]
Web: www.ncdser-innostar.com
169
Booth 40: Accelera
Accelera as Drug Development Partner of choice collaborates with international
pharmaceutical & biotech companies providing optimal quality at competitive
prices. We offer a unique range of integrated and tailored services:
• Attrition Reducing Technologies
• IND-enabling packages
• Translational sciences
• Regulatory Toxicology (incl. NHP)
• Assay development for small molecules, biologics and biomarkers
• Safety Pharmacology
• Developmental and Reproductive Toxicology
• Preclinical and Clinical Bioanalysis and PK
• ADME studies (incl. preparation of radiolabelled compounds)
• Regulatory Consultancy and documentation
Accelera is uniquely able to provide mainstream pharma capabilities and experience
in response to your preclinical development needs.
Contact: Raphaela Schnurbus, Business Development
Viale Pasteur 10 – CP 11
20014 Nerviano, Milan
Italy
Mobile: +39-334-6537744
E-Mail: [email protected]
Web: www.accelera.org
Booth 41: MPI Research
MPI Research, with global headquarters in Mattawan, Michigan, provides discovery,
safety evaluation, bioanalytical, surgical services, medical device evaluation, and
analytical services to the biopharmaceutical, medical device, animal health, and
chemical industries. We exceed expectations through consistency and quality, with
a commitment to communication and innovation, delivering benefits throughout all
phases of development. MPI Research is a high-quality organization that is committed to bringing safer and more effective products to the world. Learn how we can
go beyond for you at www.mpiresearch.com.
Contact: Phone: +1 269 668-3336
Fax: +1 269 668-4151
E-Mail:[email protected]
Web: www.mpiresearch.com
170
Booth 42/43: RTC
RTC leading CRO in Europe with 40 years of experience providing high quality in
nonclinical research to national and international pharmaceutical companies and
health-related organizations. RTC has been fully accredited by AAALAC. The company offers a full range of experimental and consultancy services, performed by
experts in the development and safety assessment of: Pharmaceuticals (Small
molecules, Biologicals), Medical Devices, Veterinary Drugs, Food Products,
Chemicals, Agrochemicals, Biocides.
Contact: RTC S.p.A.
via Tito Speri 12/14
00040 Pomezia, RM
Italy
Phone: +39 06-91095.1
Fax: +39 06-9105737
Web: www.rtc.it
Booth 44/45: BioReliance
BioReliance is a leading contract services company in the area of product safety.
We specialize in genetic toxicology screening and GLP assays, as well as transgenic
mouse carcinogenicity testing. Other services offered include Tk/Pk analysis,
clinical pathology, and animal health assessment. BioReliance has all the experience and expertise needed to design and execute a toxicology testing program
to meet your needs.
Exhibitors &
maps
Contact: Des Cave, European Account Manager, Toxicology
Phone: +44 1368 860 398
Mobile: +44 7771 864 986
E-Mail: [email protected]
Web: www.bioreliance.com
171
Booth 46: Instem
Instem is a leading provider of pre-clinical IT solutions to the Life Sciences. Instem
offers Provantis®, a fully integrated tox/path software solution. Provantis enables
data to be collected, analysed and shared across an organisation, from compound
receipt through to final report production. Provantis serves organisations of all
sizes with on-site or Software as a Service (SaaS) solutions. Instem also offers submit™, the proven SEND solution for converting, viewing, sharing and exchanging
study data and SENDView™, a tool that simplifies the review of SEND datasets.
Visit booth 46 to find out more.
Contact: Julie Jones
Stone, Staffordshire ST15 0SD
United Kingdom
Phone: +44 1785 825600
E-Mail: [email protected]
Web: www.instem.com
Booth 47: SNBL
SNBL offers toxicology and pharmacology research services in a range of study
models with a specialisation in non-human primates, including reproduction toxicology and disease modelling, supported by comprehensive in-house analytical and
pathology services, including analytical cytology and immunology.
Contact: Stephen Kern
PO Box 182
Wetherby, West Yorkshire LS22 7TB
United Kingdom
Phone: +44 1937 587345
E-Mail: [email protected]
Web: www.snbl.com
172
Booth 48: N
ational Institute of Technology and
Evaluation (NITE)
National Institute of Technology and Evaluation (NITE) is an Incorporated Administrative Agency in Japan for supporting economic and industrial administrations
such as chemical management, consumer product safety, biotechnology and accreditation from a technological perspective. NITE has developed Hazard Evaluation Support System (HESS) for supporting the evaluation of repeated dose toxicity
by category approach, which was developed by a Japanese national project, and has
released for free last year. In our booth, we will provide introduction of HESS and
user support.
E-Mail: [email protected]
Web: www.safe.nite.go.jp/english/kasinn/qsar/hess-e.html
Booth 49: Xenometrix
Xenometrix introduces a new product line including different ex vivo human skins
“XenoSkin H”. Xenometrix also offers the bioassay with yeast cells “Xenoscreen
YES/YAS” with stably transfected human estrogen and androgen receptors detecting compounds with agonistic and antagonistic hormonal activity on both receptors
in the same kit. Standardized, ready to use Ames mutagenicity assay kits “Ames
MPF” and “Ames II” in an automatable liquid microplate format (microfluctuation
assay) with significantly less compound consumption, less S9 and less hands on
time are presented. Genotoxic compounds can also be detected within 6 hrs using
the SOS response-based umuC Easy kit.
www.xenometrix.ch
Exhibitors &
maps
Web: 173
Booth 50: Brixham Environmental Laboratory
Brixham Environmental Laboratory (BEL) located in Devon, England provides a
specialised service to the chemical industry. BEL can perform the full range of environmental testing required for REACH registration, plus Chemical Safety Report
preparation. We offer innovative approaches together with intelligent laboratory
based testing required for assessing environmental effects, ecotoxicity and environmental fate of new and existing substances in support of the necessary notification dossiers. Our laboratory expertise ranges from standard notification studies
to collaborative research programmes. We offer modelling, consultancy and information services, plus analysis for Occupational Exposure Limits, and analysis of
biological samples with metabolite identification.
Contact: Brixham Environmental Laboratory
Freshwater Quarry
Brixham, Devon TQ5 8BA
United Kingdom
Phone: +44 (0)1803 884 400 (Business queries)
+44 (0)1803 882 882 (Main switchboard)
E-Mail: [email protected]
Web: www.brixham-lab.com
Booth 51: Leadscope
Leadscope licenses high quality statistical-based QSAR models developed through
our Research Collaboration Agreement with the U.S. Food & Drug Administration.
Leadscope’s Genetox QSAR Suite meets the requirements of ICH M7 draft Guidance
on testing of impurities for statistical-based models. Leadscope’s models follow the
validation principles set forth by the Organization for Economic Co-operation and
Development (OECD).
Leadscope’s QSAR models allow scientists to predict the potential toxicity of pharmaceuticals (including impurities), cosmetics, foods and chemical products. Leadscope’s models provide additional supportive evidence through analog searching of
Leadscope’s SAR Genetox database. Reports are automatically generated. The
QSAR models are easy-to-use and inexpensive.
Contact: Leadscope, Inc.
1393 Dublin Road
Columbus, Ohio 43215
United States of America
Loftus Lucas, CEO
Phone: +1 614 340-1399
E-Mail: [email protected]
Dr. Glenn Myatt
Phone: +1 614 675-3731
E-Mail:[email protected]
174
Booth 52: TRINOVA Biochem
TRINOVA Biochem offers products for mutagenicity tests: Salmonella and E. Coli
WP2 mutagenicity tests (Ames Test) comply with OECD Guideline 471, Fluctuation
tests (Moltox® FT™ tests) and BioReliance Ames IITM test kit. Umu Genotoxicity
Test and Media for water testing. All reagents for Genetic and in vitro Toxicology in
European stock: MUTAZMYE™ complete S9 incl. all Co-Factors, lyophilized and frozen metabolic activation products S9 (human, rat, mouse and hamster), Salmonella
and E-Coli tester strains, Minimal Glucose Agar Plates, Controlchem™ positive control chemicals, NADPH Regenerating System Reagents.
E-Mail:[email protected]
Web:www.trinova.de
Booth 53: TAP Biosystems
TAP Biosystems provides advanced automated systems for cell culture scale-up
and manufacture. TAP will be showcasing the RAFT™ system for producing
­biomimetic 3D cell cultures in standard plate formats. TAP’s RAFT Development
­Director Grant Cameron will be available to discuss the use of RAFT in toxicology
screens and studies.
Contact:
Europe & Rest of World
North America
TAP Biosystems
York Way
Royston, Herts, SG8 5WY
United Kingdom
Phone: +44 1763 227200
Fax:
+44 1763 227201
TAP Biosystems
20 Montchanin Road, Suite 10
Greenville DE 19807
United States of America
+1 302 478 9060
+1 302 478 9575
Exhibitors &
maps
E-Mail:[email protected]
Web: www.tapbiosystems.com
175
Booth 54: CERB
CERB is an international preclinical Contract Research Organization. CERB provides
research and development services for pharmaceutical, chemical and agro-chemical
industries in toxicology, pharmacology and analytical chemistry. CERB offers safety
evaluation in toxicology and pharmacology as required for Phase 1 clinical trials.
CERB is highly specialized in cardiovascular pharmacology, telemetry, electrophysiology and central nervous system. In addition CERB provides numerous models for
evaluation of primary and secondary pharmacology functions in other fields. In order to keep up with the most recent, interlinked advances in biomedical sciences,
CERB has elaborated a network of experts being outstanding in their respective
supplementary working disciplines.
Contact: Dr. Serge Richard
Scientific and Managing Director
Phone: +33 (248) 230023
E-mail:[email protected]
Web:www.cerb.fr
Booth 55: IUTOX
The mission of the International Union of Toxicology (IUTOX) is to improve human
health through the science and practice of toxicology world-wide. IUTOX achieves
its vision by fostering international scientific cooperation for the global acquisition
and utilization of knowledge in toxicology for improvement of the health of humans and their environment.
IUTOX seeks to increase knowledge of toxicological issues and extend this knowledge to developing societies and nations. Founded in 1980, IUTOX has 61 affiliated
societies representing six continents and over 20,000 toxicologists from industry,
academia and government; offering a diverse and challenging perspective on issues
relating to the profession.
E-mail: [email protected]
Web:www.iutox.org
176
Booth 56: vivo Science
vivo Science is a privately owned, independent CRO focused on toxicology and
­immunologic studies, as well as adventitious virus testing.
Toxicity and safety testing of chemicals and new drug candidates will be performed
according to the appropriate guidelines of the regulating agencies such as OECD,
FDA or EMA. These include, among others, the panel of OECD toxicity tests
(REACH) or testing for immunotoxicity (ICH-S8) and immunogenicity (ICH-S6). vivo
Science offers assays as required by guidelines using both in vitro and in vivo
­methods that are GLP-compliant.
vivo Science also performs the immunological testing and standard toxicity testing
for medical products.
Web:www.vivoscience.de
Booth 57: Ingenuity Systems
Founded in 1998 by Stanford graduate students, Ingenuity® Systems is a leading
provider of biomedical information and analysis solutions for the exploration,
­interpretation and analysis of complex biological systems. Ingenuity has invested
years in the innovation of semantic search, ontology, and software development to
create ground breaking technologies that help researchers more effectively search,
explore, visualize, analyze and interpret biological and chemical findings related to
genes, proteins and small molecules. In April 2013, Ingenuity Systems became part
of the QIAGEN family, and together are developing a combined NGS sample to
­insight workflow.
Exhibitors &
maps
Web:www.ingenuity.com
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Exhibitors
Booth:Company:
Booth:Company:
40
Accelera S.r.l
6
ACEA Biosciences Inc.
17
ADR-AC GmbH
11
Bertin Pharma
2Bioagri
44/45BioReliance
50
Brixham Environmental Laboratory
23
BSL Bioservice GmbH
3B’SYS
6
Bucher Biotec AG
8
Cellular Dynamics Intl.
54CERB
11
Chemie Brunschwig
28/29
CiToxLAB
18
Comet Biotech AS
19Confarma
4
Cultex Laboratories GmbH
30
CXR Biosciences
10Cyprotex
16
EBSCO Expert Publishing
38Elsevier
37
Enzo Life Sciences
14
EPL Archives
15
European Food Safety Authority (EFSA)
1European Society of Toxicology
(Eurotox 2014)
34/35
Harlan Laboratories Ltd.
7
Huntingdon Life Sciences
57
Ingenuity Systems
39Innostar
10
InSphero AG
9
Instech Solomon
46Instem
22
Institute of Industrial Organic Chemistry (IPO)
55IUTOX
51
Leadscope Inc.
5
Lhasa Ltd.
21MatTek
24Medicyte
12
MicroMatrices Associates
41
MPI Research
36
Myriad RBM Inc.
48National Institute of Technology and
Evaluation (NITE)
13
Philips Digital Pathology
42/43
Research Toxicology Centre (RTC)
32
Rhenovia Pharma
47
SNBL
19
Swiss BioAnalytics
53
TAP Biosystems
31
Tierpathologisches Labor Dr. Helmut Laaff
33Toxi-Coop
52
Trinova Biochem GmbH
20
Vitrocell Systems GmbH
56
vivo Science GmbH
25/26
WIL Research
27
WuXi AppTec
49Xenometrix
178
Exhibitors Booth Map
Club Casino
Concert Hall
50
49
48
54
55
56
57
45
46
40
F&B Zone
33
34
32
35
31
44
47
39
41
38
42
37
43
23
36
30
22
21
29
28
27
26
25
24
52
14
15
16
17
18
19
20
13
53
51
12
Entrance
1
F&B Zone
2
11
3
9
8
7
6
5
4
Exhibitors &
maps
10
179
EUROTOX Congress Awards
1. Young Scientist Poster Awards
EUROTOX Gerhard-Zbinden Award (EUR 2000)
for drug-oriented toxicological research:
• The winner will receive EUR 1000 in cash at the congress.
• The winner may use the remaining EUR 1000 to cover expenses (hotel, accommodation,
transfer, etc) to attend the successive congress edition. The claim should be made directly to the EUROTOX Treasurer using the form obtained from the EUROTOX Secretariat
([email protected]).
ECETOC (European Centre for Ecotoxicology and Toxicology
of Chemicals) Award (EUR 2000) for toxicological research
into mechanisms and risk assessment:
• The winner will receive EUR 1000 in cash at the congress.
• The winner may use the remaining EUR 1000 to cover expenses (hotel, accommodation,
transfer, etc) to attend the successive congress edition. The claim should be made directly to the EUROTOX Treasurer using the form obtained from the EUROTOX Secretariat
([email protected]).
The registration fee for Young Scientist Award recipients to attend the successive congress will be waived by the organiser of the next congress.
To be eligible for these awards, the candidate must
• be the presenting author of the abstract.
• under 35 years of age as of December 31, 2013.
• present a photo ID on site at the registration desk.
• present a letter of recommendation written by his/her supervisor.
• have successfully paid the congress registration fee.
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2. The Bo Holmstedt Memorial
Foundation (BHMF) Poster Award
A Bo Holmstedt Poster Award is awarded for describing a feasible method for the solution
of a toxicological problem under maximum respect of the 3R-principle (Reduce, Refine,
Replace animal testing).
Any author who has an abstract accepted for poster presentation in the topic “In vitro toxicology” will be automatically eligible to be candidate to the award. The winner will receive
the award in the amount of EUR 1000 in cash at the congress.
3. ESTIV Poster Award
ESTIV (European Society for Toxicology in vitro)
Award (EUR 500) for in vitro/in silico Toxicology:
• The winner will receive EUR 500 (per bank transfer after the Congress).
• The winner will be entitled to one year (2014) free ESTIV-membership, with all its
benefits.
• The winner must contact the ESTIV treasurer ([email protected]) after the congress
to claim the award.
Eligibility criteria for the ESTIV award:
• All posters presented in the sessions “in vitro Toxicology” or “Computational Toxicology”
• The winner will be selected based on scientific merit as judged by a committee assigned
by the ESTIV scientific board.
• The winner will be the presenting author of the selected poster.
Exhibitors &
maps
• The winner (or a clearly assigned representative) must be present at the EUROTOX
closing ceremony.
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