HEARTGARD Comprehensive Detailer

Transcription

THEONE
and only Real-Beef Chewable
xhg238157_ComprehensiveDetailer-9.625x7_rsg2.indd 1
6/17/15 3:02 PM
HEARTGARD® Plus
(ivermectin/pyrantel):
HEARTGARD (IVERMECTIN)
BEGAN AS AN IDEA®
Dogs prefer it more than any other
oral heartworm disease preventive2-6
an idea that if we could make protecting dogs
from heartworm disease easier, more convenient*
and lower risk**, then more dogs would get the
protection they deserve.
The ONLY Real-Beef Chewable
a
Helps prevent heartworm disease
Treats and controls 2 species
of roundworms
HEARTGARD is still the go-to choice
for veterinarians across the country.
Treats and controls 3 species
of hookworms
1
Pet owner satisfaction guaranteed 7
* Monthly vs. daily
** Severe anaphylaxis not seen when administered to microfilariae positive dogs.8
1
Vet-dispensed; CMI Data. MDI Data 2014.
2
Of dogs showing a preference in two studies conducted, all dogs preferred HEARTGARD Plus Chewables to SENTINEL® (milbemycin oxime-lufenuron) chewable tablets; Executive Summary VS-USA-37809 and VS-USA-37810.
3
Of dogs showing a preference in two studies conducted, dogs preferred HEARTGARD Plus Chewables over IVERHART PLUS® (ivermectin/pyrantel) beef-flavored tablets by a margin of 154 to 1; Executive Summary
VS-USA-37811 and VS-USA-37812.
4
Of dogs showing a preference in two studies conducted, dogs preferred HEARTGARD Plus Chewables over IVERHART MAX® (ivermectin/pyrantel/praziquantel) beef-flavored tablets by a margin of 210 to 1; Executive Summary
VS-USA-37813 and VS-USA-37814.
5
Of dogs showing a preference in one study conducted, dogs preferred HEARTGARD Plus Chewables over SENTINEL® SPECTRUM (milbemycin oxime/praziquantel/lufenuron) beef-flavored tablets by a margin of 19 to 1;
Executive Summary VS-USA-37801.
6
Of dogs showing a preference in three studies, dogs preferred HEARTGARD Chewables over INTERCEPTOR® (milbemycin oxime) Flavor Tabs® by a margin of 37 to 1; data on file at Merial.
7
Data on file at Merial.
8
Boreham PFL, Atwell RB. Absence of shock-like reactions to ivermectin in dogs infected with Dirofilaria immitis. J of Helm. 1983;57:279-281.
xhg238157_ComprehensiveDetailer-9.625x7_rsg2.indd 2-3
#1 choice of veterinarians1 and
pet owners7
IMPORTANT SAFETY INFORMATION: HEARTGARD® Plus (ivermectin/pyrantel) is well
tolerated. All dogs should be tested for heartworm infection before starting a preventive
program. Following the use of HEARTGARD Plus, digestive and neurological side effects
have rarely been reported. For more information, please visit www.HEARTGARD.com.
6/17/15 3:02 PM
HEARTWORM DISEASE IS
A YEAR-ROUND THREAT
FOR ALL DOGS, INDOORS
AND OUT.
A DANGER
TO ALL DOGS
64
PERCENT
of dogs leave clinics without a
heartworm disease preventive.9
American Heartworm Society: The severity of heartworm incidence as
shown in this map is based on the average number of cases per reporting
clinic. Some remote regions of the United States lack veterinary clinics,
therefore we have no reported cases from these areas.
9
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TRANSMISSION
& DEVELOPMENT
Larvae are easy to kill. Adult heartworms are not.
Mosquitoes
ingest heartworm
microfilariae when
they feed on
a heartworm
positive animal.
SIGNS OF
DISEASE
ONE CASE
IS ONE
TOO
MANY
HEARTWORMS
The mosquito
then carries the
heartworm larvae
to its next meal.
• Coughing
• Difficulty breathing
• Sluggishness
• Reduced ability to exercise
• Loss of consciousness
Larvae deposited
on the skin by an
infected mosquito
develop in dogs.
Heartworm larvae
migrate through the
tissue and into the
bloodstream of their
new host, continuing
to mature as they go.
Juvenile and adult
heartworms primarily
live in the pulmonary
blood vessels of an
infected dog.
Within 6 months
of infection, adult
heartworms are
present in the
pulmonary arteries.
Killing adult
heartworms poses
serious risk and
potentially traumatic
experiences to an
infected dog.
American Heartworm Society, AAHA, AVMA, CAPC,
and Partnership for Preventive Health recommend
year-round administration of heartworm prevention.
10-12
10
11
12
The American Animal Hospital Association-American Veterinary Medical Association Preventive Healthcare Guidelines Task Force. Practice
Guidelines: Development of new canine and feline preventive healthcare guidelines designed to improve pet health. JAVMA. 2011;239(5):625-629.
Nelson CT, McCall JW. Carithers DC, ed. Current Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm (Dirofilaria immitis)
Infection in Dogs. American Heartworm Society website. https://www.heartwormsociety.org/images/pdf/2014-AHS-Canine-Guidelines.pdf. January
2014. Accessed June 1, 2015.
Controlling Internal and External Parasites in U.S. Dogs and Cats. The Companion Animal Parasite Council website at http://www.capcvet.org/
recommendations/guidelines.html Accessed. December 13, 2012.
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SIGNS OF
INFECTION
Hookworm larvae can
be transmitted through:
• Ingestion of contaminated soil
• Larvae in soil that penetrates the skin
• The milk of infected mothers nursing their pups
• Weakness
• Diarrhea
&
TREATS
CONTROLS
• Pale gums
• Weight loss
IMPORTANT RISK INFORMATION: HEARTGARD® Plus (ivermectin/pyrantel) is well tolerated.
All dogs should be tested for heartworm infection before starting a preventive program.
Following the use of HEARTGARD Plus, digestive and neurological side effects have rarely
been reported. For more information, please visit www.HEARTGARD.com.
Not all heartworm disease
preventives treat and control
hookworm and roundworm infections.
Toxocara canis
Toxascaris leonina
TRANSMISSION
TO DOGS
TRANSMISSION
TO DOGS
Ancylostoma braziliense
Ancylostoma caninum
Uncinaria stenocephala
ROUNDWORMS
SIGNS OF
INFECTION
HOOKWORMS
Roundworm larvae
can be transmitted:
• Through direct contact with the
feces of an infected animal
• The milk of infected mothers nursing their pups
• Transplacentally
• Diarrhea
• Vomiting
• Weight loss
• Malnutrition
• Worms in feces
• Weakness
• Swollen abdomen
• Lack of appetite
HEARTGARD Plus prevents heartworm disease,
PLUS treats and controls 3 species of hookworms
and 2 species of roundworms.
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PREVENTS.
TREATS.
CONTROLS.
ONLY HEARTGARD Plus (ivermectin/pyrantel)
prevents heartworm disease & treats & controls
pre-existing hookworm & roundworm infections
with a Real-Beef Chewable dogs love to take.13
13
Freedom of Information: NADA140-971 (January 15, 1993).
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WHAT VETS
ARE SAYING:
“...the ease of using Merial’s
HEARTGARD Plus, the fact
that it’s very tasty, dogs take it
easily, clients love that. It’s well
recognized, well advertised - it’s
really easy to utilize a product
that’s that effective.”
-Michael Kolatis, DVM
Fort Lawn Animal
Hospital, SC.
WHAT PET
OWNERS
ARE SAYING:
“I have tried other heartworm
preventives but my dogs like
HEARTGARD Plus the best. It’s like
dog candy, they like it, it’s not a
struggle. I don’t have to shove it
down their throats.”
-Kim, Pet Owner
Archer, Florida.
6/17/15 3:02 PM
The ivermectin in HEARTGARD Plus works retroactively,
killing L3 and L4 larvae that the dog may have acquired
in the previous 30 days.14
Pyrantel pamoate kills roundworms & hookworms as it
passes THROUGH the intestinal track; it is NOT absorbed.15
HOW IT
WORKS
Without a preventive, heartworm larvae will develop to juvenile
and adult heartworms that can cause heartworm disease.
HEARTGARD Plus should be given every 30 days, all year long.11
IMPORTANT SAFETY INFORMATION: HEARTGARD® Plus (ivermectin/pyrantel) is well tolerated. All dogs should be tested for heartworm
infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurological side effects have rarely
14
15
HEARTGARD Plus Product Label.
Plumb DC. Plumb’s Veterinary Drug Handbook. 4th ed. Ames, Iowa;Iowa State University Press (Blackwell); 2002:746.
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IN
EASY,
OUT
QUICKLY
HEARTGARD PLUS (IVERMECTIN/PYRANTEL)
USES AN EXTREMELY LOW DOSE OF
IVERMECTIN AND IS RAPIDLY EXCRETED
FROM THE DOG
3 days
Once consumed
ivermectin is quickly
excreted in 3 days.16
16
Daurio CP, Cheung EN, Jeffcoat AR, Skelly BJ. SDG Ef Daurio CP et al. Bioavailability
of ivermectin administered orally to dogs. Vet Res Comm. 1992;16(2):125-130.
IMPORTANT SAFETY INFORMATION: HEARTGARD® Plus (ivermectin/pyrantel) is well tolerated. All dogs should be tested for
heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurological
side effects have rarely been reported. For more information, please visit www.HEARTGARD.com.
6/17/15 3:02 PM
HEARTGARD (IVERMECTIN)
BRAND PRODUCTS
HAVE BEEN PREVENTING
HEARTWORM DISEASE
FOR OVER 25 YEARS –
BILLIONS OF
DOSES SOLD.
®
TRIED
AND TRUE
APPROVED FOR USE IN
• Puppies as young as 6 weeks of age
• Small dogs regardless of weight
• Pregnant and breeding mothers
• Studs
• All breeds, including Collies
17
17
IMPORTANT SAFETY INFORMATION: HEARTGARD® (ivermectin) is well tolerated. All
dogs should be tested for heartworm infection before starting a preventive program.
Following the use of HEARTGARD, digestive and neurological side effects have rarely
6/17/15 3:02 PM
TREAT YOUR PATIENTS TO
THE MONTHLY HEARTWORM
PREVENTION DOGS PREFER.2-6
In 10 studies, in dogs showing a preference,
dogs preferred HEARTGARD Plus (ivermectin/pyrantel):
219 to 0
over SENTINEL® 2
154 to 1 over IVERHART PLUS
®3
210 to 1 over IVERHART MAX
®4
19 to 1 over SENTINEL SPECTRUM
®5
37 to 1 over INTERCEPTOR
®6
NO
PEANUT
BUTTER
REQUIRED
6/17/15 3:02 PM
IMPORTANT SAFETY INFORMATION: HEARTGARD® Plus (ivermectin/pyrantel)
is well tolerated. All dogs should be tested for heartworm infection before
starting a preventive program. Following the use of HEARTGARD Plus, digestive
and neurological side effects have rarely been reported. For more information,
please visit www.HEARTGARD.com.
QUALIFYING
POSITIVE
TESTS
The PLUS Guarantee is the only guarantee of its
kind that offers exclusive peace of mind for pet
owners with trusted prevention for their pet – and
it’s only available from your veterinary clinic.
ELIGIBILITY
The
Guarantee backs your recommendation by promising
outstanding performance.
DURATION OF
ADMINISTRATION
PREVENTING HEARTWORM DISEASE.
SATISFACTION GUARANTEED.
HEARTWORMS
Dogs starting on HEARTGARD Plus Chewables: between 6 weeks and 4 months of age – covered
immediately for protection against heartworms; between 4 and 6 months of age – covered following a
negative antigen test 6 months after the first dose; 6 months of age and older – covered if antigen test
performed prior to first dose and 6 months following first dose prove negative; 6 months of age or older
when switching from another brand of heartworm preventive to HEARTGARD Plus – covered if an antigen
test performed within 2 weeks prior to the first dose of HEARTGARD Plus proves negative. Thereafter,
antigen test must be administered to dogs annually.
19
Proof of purchase required.
20
Vital statistics for your veterinary practice. In: Landeck E, ed. The Veterinary Fee Reference. 3rd ed.
Lakewood, CO:AAHA Press; 2003:43-44, 56, 62-63, 71, 152-153, 310.
21
Product will be replaced with HEARTGARD (ivermectin) tablets.
COMPENSATION
18
Dogs infected with heartworms after monthly
administration with HEARTGARD
• HEARTGARD Brand Products must be obtained only from
you, a licensed practitioner, with a veterinarian/client/
patient relationship18
• Dogs may qualify only once, per lifetime of the dog,
for either Level 1 or Level 2
INTESTINAL PARASITES
Dogs infected with roundworms or
hookworms after monthly administration
with HEARTGARD Plus
• HEARTGARD Plus must be obtained only
from you, a licensed practitioner, with a
veterinarian/client/patient relationship18
Level 1
9 months continuously,* as
recommended by a veterinarian19
• Dogs starting on HEARTGARD
between 6 weeks and 4 months
of age are covered immediately.
between 4 and 6 months of
age are covered following
a negative antigen test 6
months after the first dose is
administered.
after 6 months of age are
covered if antigen tests
performed prior to the first dose
and 6 months following the first
dose prove negative.
Thereafter, antigen tests must be
administered to dogs annually.
Level 2
9 months, but with missed dose[s]
and/or insufficient negative antigen
testing record19
The dose must have been
taken within 31 days
2 positive antigen tests
performed on 2 separate
blood samples
2 positive antigen tests
performed on 2 separate
blood samples
Identification of parasite eggs by fecal
flotation in the clinic
Level 1
Level 2
• $500 for veterinary services20
• Complimentary product for
treatment of heartworm disease
Reimbursement for the cost of positive
fecal exam and the cost of treatment
based on dog’s weight†,**
• Complimentary product for
treatment of heartworm disease
• One-year supply of HEARTGARD
• One-year supply of HEARTGARD
PALATABILITY
Dogs that do not accept
HEARTGARD Real-Beef Chewables
• HEARTGARD Real-Beef Chewables must
be obtained only from you, a licensed
practitioner, with a veterinarian/client/
patient relationship18
Product credit or replacement
for dogs only with HEARTGARD
tablets21
This guarantee will be honored at Level 1 with administration
of 9 doses administered consecutively during peak transmission
season (March through October).
†
Dogs housed in intensified population facilities of 6 dogs or more
will be covered under this guarantee for heartworms but not for
intestinal parasites.
**
Reimbursement is based on a set fee schedule and may not
equal the amount charged to the client by the veterinary clinic.
*
6/17/15 3:02 PM
EASY
TO GIVE,
EASY TO
DOSE
HEARTGARD PLUS
(IVERMECTIN/PYRANTEL)
IS AVAILABLE IN 6-PACKS
& 12-PACKS & COMES
IN THREE SIZES, FOR
CONVENIENT DOSING:
for dogs up to 25 lbs
for dogs 26-50 lbs
for dogs 51-100 lbs
Dogs larger than 100 lbs. should receive
an appropriate combination of sizes.
6/17/15 3:02 PM
ALL
IN THE
FAMILY
IMPORTANT SAFETY INFORMATION: HEARTGARD is well tolerated. All dogs should be tested
for heartworm infection before starting a preventive program. Following the use of HEARTGARD
Plus, digestive and neurological side effects have rarely been reported. For more information,
please visit www.HEARTGARD.com.
®
IMPORTANT SAFETY INFORMATION: HEARTGARD (ivermectin) for Cats is well tolerated. In the
clinical studies involving more than 3,000 doses of HEARTGARD for Cats, observations reported
within 24 hours of treatment included vomiting in ≤0.3% and diarrhea in ≤0.2% of the doses
administered. There was no statistical difference between HEARTGARD for Cats and the product
vehicle (control) for these observations. For more information, please visit www.HEARTGARD.com.
®
OTHER HEARTGARD
(IVERMECTIN) PRODUCTS
AVAILABLE FROM MERIAL INCLUDE:
• Tablets for Heartworm
Disease Prevention Only
• Does Not Contain Beef
• Available in 6 Packs
• Real-Beef Chewable
for Heartworm Disease
Prevention Only
• Chewable for Heartworm
Disease Prevention
• Treats and Controls Both Adult
and Immature Hookworms
6/17/15 3:02 PM
WE’RE HERE TO HELP YOU
PROTECT MORE DOGS.
Ask your Merial Sales Representative for more details.
CLINIC SUPPORT:
a
1
Consumer Advertising
7
Puppy Kits
2
Consumer Coupons
8
Taste Test Treats
3
PLUS Guarantee
9
HEARTGARD Wallets
4
CLIENT CONNECTIONTM
10
Seasonal Promotions
5
joinpowerof12.com
11
Reminder App
6
Clinic Merchandising
& Educational Tools
12
Local Support
6/17/15 3:02 PM
CHEWABLES FOR CATS
TABLETS
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
INDICATIONS: For use in cats to prevent feline heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria
immitis) for a month (30 days) after infection, and for the removal and control of adult and immature hookworms (Ancylostoma tubaeforme
and A. braziliense).
DOSAGE: HEARTGARD® (ivermectin) for Cats should be administered orally at monthly intervals at the recommended minimum dose level of
24 mcg of ivermectin per kg (10.9 mcg/lb.) of body weight. The recommended dosage schedule for prevention of feline heartworm disease and
control of hookworm is as follows:
Cat Weight
lb
HEARTGARD for Cats
Chewables per month
Ivermectin
content
up to 5 lb
5 to 15 lb
1
1
55 mcg
165 mcg
For cats over 15 lb., use the appropriate combination of chewables.
HEARTGARD for Cats is recommended for use in cats 6 weeks of age and older.
ADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables
to its box to protect the product from light. HEARTGARD for Cats can be offered to the cat by hand or may be added to a small amount of cat
food. If manual dosing is required, the chewable should be broken into pieces for administration. Food should be routinely available during the
day of treatment administration. If cats are fasted, or if the chewable is not broken into pieces for manual dosing, then reduced absorption
may result. A relationship between reduced absorption and reduced efficacy has not been established.
Care should be taken to see that the cat consumes the complete dose. Treated animals should be observed for a few minutes after
administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing with a new
chewable is recommended. Fragments of chewables have occasionally been observed in the feces of some cats; efficacy of the product was
not adversely affected.
HEARTGARD for Cats should be given at monthly intervals when mosquitoes potentially carrying infective heartworm larvae are active. The
initial dose must be given within a month (30 days) after the cat’s first exposure to mosquitoes. The final dose must be given within a month
(30 days) after the cat’s last exposure to mosquitoes. For optimal performance, HEARTGARD for Cats must be given once a month on or about
the same date. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD for Cats and resumption of the
recommended dosing regimen will minimize the opportunity for development of adult heartworm.
It is recommended that cats should be tested for existing heartworm infection prior to starting treatment with HEARTGARD for Cats. Cats
already infected with adult heartworms can be given HEARTGARD for Cats monthly to prevent further infections.
Monthly treatment with HEARTGARD for Cats also provides effective removal and control of adult and immature hookworms (A. tubaeforme
and A. braziliense).
SAFETY: In the clinical studies involving more than 3000 doses of HEARTGARD for Cats, observations reported within 24 hours of treatment
included vomition in ≤ 0.3% and diarrhea in ≤ 0.2% of the doses administered. There were no statistical differences between HEARTGARD for
Cats and the product vehicle (control) for these observations.
A wide margin of safety was demonstrated in clinical trials at the recommended dose level in cats and kittens 6 weeks of age and older
and in laboratory studies in cats with circulating microfilariae of D. immitis. A wide margin of safety has also been demonstrated at 3 times
the recommended dose in pregnant or breeding queens and breeding toms. No adverse effects were observed in either male or female cats
or their offspring in breeding studies. A 30-fold safety margin over the minimum recommended dosage was established in a single dose
tolerance study. In growing kittens dosed monthly for 8 consecutive doses, one cat given 5 times the market dose vomited and a second
cat in this group experienced diarrhea within 24 hours of the initial treatment. In clinical trials, many commonly used flea control products,
anthelmintics, vaccines, antibiotics and steroid preparations were administered with HEARTGARD for Cats without incident.
Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a
physician immediately.
STABILITY: HEARTGARD Chewables for Cats are stable for 3 years when stored below 77°F (25˚C) and protected from light. Store at
controlled room temperature of 68°F - 77°F (20°C - 25°C). Excursions between 59°F - 86°F (15°C - 30°C) are permitted.
HOW SUPPLIED: HEARTGARD for Cats is available in two dosage strengths (see DOSAGE section) for cats of different weights. Each
strength comes in a convenient carton of 6 chewables, packed 10 cartons per tray.
For customer assistance, please contact Merial at 1-888-637-4251.
CHEWABLES
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
INDICATION: For use in dogs to prevent canine heartworm disease. HEARTGARD® prevents heartworm disease by eliminating the tissue
stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection.
DOSAGE: HEARTGARD Tablets should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of
ivermectin per kilogram (2.72 mcg/lb) of body weight. (See ADMINISTRATION). The recommended dosage schedule for prevention of canine
heartworm disease is as follows:
Dog
Weight
Up to 25 Ib
26 to 50 Ib
51 to 100 lb
Tablets
PerMonth
1
1
1
Ivermectin
Per Tablet
68 mcg
136 mcg
272 mcg
Color
on Carton
Blue
Green
Brown
Give dogs over 100 Ib the appropriate combination of tablets.
HEARTGARD is recommended for use in dogs 6 weeks of age and older.
ADMINISTRATION: The HEARTGARD tablet should be given so that dogs swallow the whole tablet. (The tablet may be wrapped in food to
encourage consumption.) Care should be taken to see that the dog consumes the complete dose, and treated animals should be observed for
a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost,
redosing is recommended. HEARTGARD Tablets should be given at monthly intervals during the period of the year when mosquitoes (vectors),
potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the first exposure to
mosquitoes. The final dose must be given within a month (30 days) after the last exposure to mosquitoes.
When replacing another heartworm preventive in a heartworm disease preventive program, the first dose of HEARTGARD must be given
within a month (30 days) after the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. For optimal performance, the tablet must
be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment
with HEARTGARD and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
EFFICACY: HEARTGARD Tablets, given orally using the recommended dose and regimen, are effective against the tissue larval stage of
Dirofilaria immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage.
PRECAUTIONS: All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD (ivermectin) Tablets,
which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae prior to initiating
a program with HEARTGARD.
While some microfilariae may be killed by the ivermectin in HEARTGARD at the recommended dose level, HEARTGARD is not effective for
microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a
transient diarrhea, has been observed in clinical trials with ivermectin after the treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician
immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
ADVERSE REACTIONS: The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy,
vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.
SAFETY: HEARTGARD has shown a wide margin of safety at the recommended dose level in dogs (See PRECAUTIONS for exceptions)
including pregnant or breeding bitches, stud dogs, and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars,
dips, shampoos, anthelmintics, antibiotics, vaccines, and steroid preparations have been administered with HEARTGARD in a heartworm
disease preventive program.
Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated
dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions
which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. HEARTGARD
demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials support the
safety of HEARTGARD products in dogs, including Collies, when used as recommended.
HOW SUPPLIED: HEARTGARD is available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength
comes in a convenient carton of 6 tablets, packed 10 cartons per tray.
Store at controlled room temperature 68° - 77°F (20° - 25°C).
®HEARTGARD, the Dog & Hand Logo and the Cat & Hand logo are registered trademarks, and
™CLIENT CONNECTION is a trademark, of Merial. All other marks are the property of their respective
owners. ©2015 Merial, Inc., Duluth, GA. All rights reserved.HGD15TRTECHDETAILER (03/15).
Marketed by Merial Limited || Duluth, GA 30096-4640 || Made in U.S.A. || Rev. 01-2012 || 1050-4383-00
CHEWABLES
INDICATION: For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis)
for a month (30 days) after infection.
DOSAGE: HEARTGARD® (ivermectin) Chewables should be administered orally at monthly intervals at the recommended minimum dose
level of 6.0 mcg of ivermectin per kilogram (2.72 mcg/lb) of body weight. (See ADMINISTRATION). The recommended dosage schedule for
prevention of canine heartworm disease is as follows:
INDICATIONS: For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for
a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma
caninum, Uncinaria stenocephala, Ancylostoma braziliense).
DOSAGE: HEARTGARD® Plus (ivermectin/pyrantel) should be administered orally at monthly intervals at the recommended minimum dose level of
6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing
schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:
Dog
Weight
Chewables
Per Month
Ivermectin
Content
Color Coding 0n
Foil Backing
and Carton
Dog
Weight
Chewables
Per Month
Ivermectin
Content
Pyrantel
Content
Color Coding 0n
Foil Backing
and Carton
Up to 25 lb
26 to 50 lb
51 to 100 lb
1
1
1
68 mcg
136 mcg
272 mcg
Blue
Green
Brown
Up to 25 lb
26 to 50 lb
51 to 100 lb
1
1
1
68 mcg
136 mcg
272 mcg
57 mg
114 mg
227 mg
Blue
Green
Brown
Give dogs over 100 Ibs the appropriate combination of these chewables.
HEARTGARD Chewables are recommended for use in dogs 6 weeks of age and older.
ADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to
the box to protect the product from light. Because most dogs find HEARTGARD Chewables palatable, the product can be offered to the dog by
hand. Alternatively, it may be added to a small amount of dog food. The chewable should be administered in a manner that encourages the dog
to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.
Care should be taken to see that the dog consumes the complete dose, and treated animals should be observed for a few minutes after
administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
HEARTGARD Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying
infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes.
The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.
When replacing another heartworm preventive in a heartworm disease preventive program, the first dose of HEARTGARD must be given
within a month (30 days) after the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. For optimal performance, the chewable must
be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment
with HEARTGARD and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
EFFICACY: HEARTGARD Chewables, given orally using the recommended dose and regimen, are effective against the tissue larval stage of
Dirofilaria immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage.
ACCEPTABILITY: In acceptability and field trials, HEARTGARD Chewables were shown to be an acceptable oral dosage form that was
consumed at the first offering by the majority of dogs.
PRECAUTIONS: All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD, which is not
effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae prior to initiating a program
with HEARTGARD.
While some microfilariae may be killed by the ivermectin in HEARTGARD at the recommended dose level. HEARTGARD is not effective for
microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a
transient diarrhea, has been observed in clinical trials with ivermectin after treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician
immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
Store between 68°F–77°F (20°C–25°C). Excursions between 59°F–86°F (15°C–30°C) are permitted. Protect product from light.
ADVERSE REACTIONS: The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy,
vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.
SAFETY: HEARTGARD has shown a wide margin of safety at the recommended dose level in dogs (See PRECAUTIONS for exceptions)
including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. ln clinical trials, many commonly used flea collars,
dips, shampoos, anthelmintics, antibiotics, vaccines, and steroid preparations have been administered with HEARTGARD Chewables in a
heartworm disease preventive program.
Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated
dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions,
which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. HEARTGARD
demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials support the safety
of HEARTGARD products in dogs, including Collies, when used as recommended.
HOW SUPPLIED: HEARTGARD Chewables are available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each
strength comes in convenient cartons of 6 chewables, packed 10 cartons per tray.
HEARTGARD Plus is recommended for dogs 6 weeks of age and older. For dogs over 100 lb use the appropriate combination of these chewables.
ADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box
to protect the product from light. Because most dogs find HEARTGARD Plus palatable, the product can be offered to the dog by hand. Alternatively, it
may be added intact to a small amount of dog food.The chewable should be administered in a manner that encourages the dog to chew, rather than
to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.
Care should be taken that the dog consumes the complete dose, and treated animals sho uld be observed for a few minutes after administration to
ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective
heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must
be given within a month (30 days) after the dog’s last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD Plus must be given
within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable
must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment
with HEARTGARD Plus and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.
Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum,
U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
EFFICACY: HEARTGARD Plus Chewables, given orally using the recommended dose and regimen, are effective against the tissue larval stage of
D.immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. HEARTGARD Plus Chewables are also
effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense).
ACCEPTABILITY: In acceptability and field trials, HEARTGARD Plus was shown to be an acceptable oral dosage form that was consumed at first
offering by the majority of dogs.
PRECAUTIONS: All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective
against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.
While some microfilariae may be killed by the ivermectin in HEARTGARD Plus at the recommended dose level, HEARTGARD Plus is not effective for
microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient
diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children.
In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for
advice concerning cases of ingestion by humans.
Store between 68°F - 77°F (20°C - 25°C). Excursions between 59°F - 86°F (15°C - 30°C) are permitted. Protect product from light.
ADVERSE REACTIONS: In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of
administered doses). The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia,
diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.
SAFETY: HEARTGARD Plus has been shown to be bioequivalent to HEARTGARD, with respect to the bioavailability of ivermectin. The dose regimens of
HEARTGARD Plus and HEARTGARD are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie
breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other
breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency,
excitability, stupor, coma and death. HEARTGARD demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies.
Results of these trials and bioequivalency studies, support the safety of HEARTGARD products in dogs, including Collies, when used as recommended.
HEARTGARD Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and
puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid
preparations have been administered with HEARTGARD Plus in a heartworm disease prevention program.
In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in
intestinal transit time.
HOW SUPPLIED: HEARTGARD Plus is available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength comes
in convenient cartons of 6 and 12 chewables.
For customer service, please contact Merial at 1-888-637-4251.
6/17/15 3:02 PM
Easy to give, protection to live.
www.HEARTGARD.com
xhg238157_ComprehensiveDetailer-9.625x7_rsg2.indd 32
6/17/15 3:02 PM

HEARTGARD Comprehensive Detailer

Transcription

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