Catalog - Merial Rewards
Transcription
Catalog - Merial Rewards
HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) catalog of educational and supportive materials. ®MERIAL, HEARTGARD, FRONTLINE and the Dog & Hand and Cat & Hand logos are registered trademarks, ™SPAP and ™Paws to Save Pets and the Paw and Blue Ribbon logo are trademarks, and SMMerial EDU is a servicemark, of Merial. ©2008 Merial Limited, Duluth, GA. All rights reserved. HGD08PROCATALOG HEARTGARD ® (ivermectin) HEARTGARD ® Plus (ivermectin/pyrantel) The true measure of a clinic’s success is its ability to provide clients the best care and treatment available. An excellent way to help achieve this goal is to display engaging and informative educational resources in clinic. The following catalog offers a wide variety of educational and promotional internal parasite resources to support your staff and inform your clients. Pages 1– 9 In-Clinic Education Tools and Materials Pages 10–13 Client Take-Home Materials Pages 14–24 Compliance Aids Pages 25–30 Product Support Tools for Clinic Staff HEARTGARD is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD, digestive and neurological side effects have rarely been reported. For more information, please visit www.HEARTGARD.com. HEARTGARD is well tolerated. In the clinical studies involving more than 3,000 doses of HEARTGARD for Cats, observations reported within 24 hours of treatment included vomiting in ≤ 0.3% and diarrhea in ≤ 0.2% of the doses administered. There was no statistical difference between HEARTGARD for Cats and the product vehicle (control) for these observations. For more information please visit www.HEARTGARD.com. In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) 37:1 Taste Preference Framed Poster Description: Framed, high-quality artwork Benefit: Educates clients on how easy it is to give HEARTGARD Plus heartworm preventive medicine. Also helps support clinic recommendation for HEARTGARD Plus as the easy-to-give preventive, which can help lead to greater compliance. Target Display Area(s): Waiting room/reception area, hallways, exam rooms 1 In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Dogs Playing Poker Framed Poster Description: Framed, high-quality artwork Benefit: Educates clients on protecting their pets from deadly heartworm disease and helps support clinic recommendation for HEARTGARD Brand Products. Target Display Area(s): Waiting room/reception area, hallways, exam rooms 2 National and State Heartworm Incidence Maps In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) What’s Eating Your Dog? Poster Description: Mounted educational poster Benefit: Provides clinic staff and clients the ability to see all common parasites and where they are located in the dog. Target Display Area(s): Waiting room/reception area, exam rooms 3 In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) National and State Heartworm Incidence Maps Description: Mounted (national) and non-mounted (state) educational posters Benefit: Educates clients on the serious risks and widespread incidences of heartworm disease in all U.S. states. (National map includes incidence by state; state maps include incidence at the county level.) Target Display Area(s): Waiting room/reception area, hallways, exam rooms 4 In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Heartworm Life Cycle Poster Description: Mounted educational poster Benefit: Educates clients about the heartworm life cycle and how this dangerous disease develops and spreads – putting both dogs and cats at risk. Target Display Area(s): Waiting room/reception area, hallways, exam rooms 5 In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Heartworm Model Description: 3D clay model of a dog heart infected by heartworms Benefit: A convenient counter tool to aid in educating clients about heartworm disease and the risks associated with not using a monthly heartworm preventive. Target Display Area(s): Exam rooms 6 In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Tasty Treat Kit and Refill Bags Description: Display unit that contains a jar full of real-beef, non-medicated tasty treats Benefit: Allows vets and clinic staff to demonstrate to clients just how easy it is to give a monthly heartworm preventive with real beef. Target Display Area(s): Checkout area, reception area, exam rooms 7 In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) FPO Zoonosis Sandbox Model Description: A two-sided box (magnified and non-magnified view) depicting a mini-sandbox Benefit: Assists vets and clinic staff in demonstrating how everyday environments can become contaminated with the eggs and larvae of roundworms and hookworms. Target Display Area(s): Waiting room, exam room 8 In-Clinic Education Tools and Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Open/Closed Sign Description: Open/Closed, Hours of Operation branded window sign Benefit: Helpful signage to show clients the clinic’s hours and remind them about HEARTGARD and FRONTLINE Brand Products. Target Display Area(s): Front door/window 9 Client Take-Home Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Client Brochures Description: Color, tri-fold educational brochures Benefit: Allows clinics to provide clients with valuable educational materials in convenient, easy-to-read brochures on the topics of heartworms, roundworms, hookworms and specific HEARTGARD Brand Product information for both dogs and cats. Target Display Area(s): Checkout area, waiting room/reception area, exam rooms 10 Client Take-Home Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Information Center for HEARTGARD and FRONTLINE® Brand Products Description: Product brochure, rebate and coupon pad holder Benefit: A convenient, one-stop materials organizer for clients. Target Display Area(s): Waiting room/reception area, checkout area 11 Client Take-Home Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) The Plus Guarantee* from HEARTGARD Plus Tear Pad Description: Tear-off information sheet for clients Benefit: Supports clinic recommendations for HEARTGARD by offering a convenient source of information about the Plus Guarantee* from HEARTGARD. Target Display Area(s): Checkout area, reception area *Guarantee void where prohibited by law. Payment obligation by Merial shall be limited solely to that which is represented in the official Plus Guarantee. Any and all other costs are expressly excluded. 12 Client Take-Home Materials HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Puppy and Kitten Kits Description: Starter kit for new puppy/kitten owners Benefit: A helpful starter kit with important information, free samples, coupons and rebates that vets can offer to new puppy and kitten owners to help encourage a long-lasting pet care relationship. Target Display Area(s): Checkout area, reception area, exam rooms 13 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Calendar/Check-writing Counter Mat Description: Counter mat Benefit: A helpful reference tool for clinics that offers a 2-year calendar and check-writing surface. Target Display Area(s): Checkout area, reception area 14 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Rebate/Coupon Pads Description: Tear-off $5 rebate pads Benefit: A helpful, money-saving offer on the purchase of 12-packs of HEARTGARD Brand Products that clinics can offer to clients to help encourage year-round use and promote monthly compliance. Target Display Area(s): Checkout area, reception area 15 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Email Reminder Pads Description: Tear-off and sticky-back reminder pads Benefit: A helpful take-home tip that clinics can offer to clients on how to sign up for monthly email reminders to give their dog or cat HEARTGARD, and help encourage monthly compliance. Target Display Area(s): Checkout area, reception area 16 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Appointment and Reminder Cards Description: Useful appointment and reminder cards that can be provided/mailed to clients; available in three versions to meet your printing requirements (3-Up, 4-Up and Pinfed) Benefit: Aids clinics in supporting pet health and compliance by reminding clients of scheduled appointments or alerting them when it is time to make an appointment. Target Display Area(s): Checkout area, reception 17 ComplianceAids Aids Compliance ® ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) HEARTGARD Chart Stickers Description: Stickers used to indicate that a pet is currently on HEARTGARD Benefit: Provides a quick visual reference in a pet’s chart, or on a receipt, to indicate that a purchase of HEARTGARD has been made. Target Display Area(s): Pet’s chart, receipts submitted with coupons/rebates 18 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Superior Protection Awards Program™ (SPAP) Description: Points program that rewards clinic staff for promoting proper pet health care Benefit: SPAP is a reward program for clinic staff that allows them to collect points when they dispense large packs of FRONTLINE® and HEARTGARD Brand Products. Target Display Area(s): Staff room 19 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) In-Clinic Dispensing Programs Description: Programs and promotions designed to increase dispensing in clinic Benefit: Offers clinic staff additional opportunities to open a dialog with clients about pet health care issues and preventive medicine, and also encourages monthly compliance. Target Display Area(s): Checkout area, reception area 20 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) The Plus Guarantee* of Satisfaction Description: The Plus Guarantee* supports the outstanding performance of HEARTGARD Plus Benefit: Allows vets and clinic staff to dispense HEARTGARD with confidence, and supports the following categories: •Heartworm prevention •Treatment and control of roundworms and hookworms • Palatability Target Display Area(s): Checkout area, waiting room, reception area *Guarantee void where prohibited by law. Payment obligation by Merial shall be limited solely to that which is represented in the official Plus Guarantee. Any and all other costs are expressly excluded. 21 Compliance Aids HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Direct-to-Consumer Communications (Website and TV Advertising) Description: HEARTGARD.com and HEARTGARD consumer TV ads Benefit: The website is an educational resource for consumers that offers information on heartworm disease, roundworms and hookworms and HEARTGARD Brand Products, while TV advertising supports heartworm disease awareness and product recommendations. 22 ComplianceAids Aids Compliance ® ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) Vet-to-Pet Home Delivery Description: Home delivery service for FRONTLINE® and HEARTGARD Brand Products Benefit: Supports the relationship between vets and clients by offering clients a very convenient service. This service also supports compliance through regular monthly usage of HEARTGARD Brand Products. Target Display Area(s): Checkout area, reception area, clinic windows 23 ComplianceAids Aids Compliance ® ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) Heartworm Testing Policy Plaque Description: Wall mounted display Benefit: A helpful tool that communicates the importance of heartworm disease testing and prevention as per American Heartworm Society guidelines. Target Display Area(s): Waiting room and/or exam rooms 24 Compliance Aids Product Support Tools for Clinic Staff ® ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) Fecal Parasite Examination Log Book Description: 3-ring binder (with refill page packs available) Benefit: Provides vets and clinic staff with a convenient reference tool for use while examining blood and fecal samples, and helps facilitate and encourage best practice in clinic. Target Display Area(s): Lab area 25 Support Tools ClinicStaff Staff ProductProduct Support Tools forfor Clinic ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus ®(ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) Microscope Mat Description: Microscope mat with magnified images of internal parasites Benefit: Provides vets and clinic staff with a convenient reference tool for use while examining blood and fecal samples. Target Display Area(s): Lab area 26 Product Support Tools for Clinic Staff HEARTGARD ® (ivermectin) HEARTGARD® Plus (ivermectin/pyrantel) Paws to Save Pets™ Description: Paws to Save Pets was founded in 2006 in response to the devastation left behind by Hurricane Katrina and today continues to support pets affected by disasters. Through the Petfinder.com Foundation and the American Veterinary Medical Foundation, Paws to Save Pets provides disaster relief assistance and preparedness to help ensure the health and well-being of companion animals throughout the U.S. Target Display Area(s): To learn more visit www.pawstosavepets.com 27 Support Tools ClinicStaff Staff ProductProduct Support Tools forfor Clinic ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus ®(ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) Clinic Staff Name Badge and Coaching Card Description: Name badges with magnetic closure Benefit: A functional tool that helps prompt discussion between staff and clients on the importance of monthly heartworm prevention, particularly HEARTGARD Plus. The name badges are accompanied by a laminated coaching card that will aid clinic staff in communicating key points on promoting year-round use of a heartworm preventive. Target Display Area(s): Scrubs/front desk 28 Support Tools ClinicStaff Staff ProductProduct Support Tools forfor Clinic ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus ®(ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) Professional Support for Technical Questions Description: Field-based and telephone technical support Benefit: Provides clinics with constant access to information on products, disease states, etc., when they need it most simply by calling: • 1-888-MERIAL-1 and selecting option 3, or • your Merial Sales Representative 29 Support Tools ClinicStaff Staff ProductProduct Support Tools forfor Clinic ® ® ® HEARTGARD (ivermectin) HEARTGARD Plus ®(ivermectin/pyrantel) HEARTGARD (ivermectin) HEARTGARD Plus (ivermectin/pyrantel) (www.vetmedteam.com) Staff Training Programs Description: VETerinaire, Merial U and Merial EDU Benefit: Fun, interactive, educational programs designed to provide vets and clinic staff with information and support on disease states and Merial products. 30 CHEWABLES CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS: For use in cats to prevent feline heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection, and for the removal and control of adult and immature hookworms (Ancylostoma tubaeforme and A. braziliense). DOSAGE: HEARTGARD® (ivermectin) Chewables for Cats should be administered orally at monthly intervals at the recommended minimum dose level of 24 mcg of ivermectin per kg (10.9 mcg/lb.) of body weight. The recommended dosage schedule for prevention of feline heartworm disease and control of hookworms is as follows: Cat Weight Lbs HEARTGARD for Cats Chewables per month Ivermectin content up to 5 5 to 15 1 1 55 mcg 165 mcg For cats over 15 lb., use the appropriate combination of chewables. HEARTGARD Chewables for Cats is recommended for use in cats 6 weeks of age and older. ADMINISTRATION: Remove only one Chewable at a time from the foil-backed blister card. Return the card with the remaining Chewables to its box to protect the product from light. HEARTGARD Chewables for Cats can be offered to the cat by hand or may be added to a small amount of cat food. If manual dosing is required, the Chewable should be broken into pieces for administration. Food should be routinely available during the day of treatment administration. If cats are fasted, or if the Chewable is not broken into pieces for manual dosing, then reduced absorption may result. A relationship between reduced absorption and reduced efficacy has not been established. Care should be taken to see that the cat consumes the complete dose. Treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing with a new Chewable is recommended. Fragments of Chewables have occasionally been observed in the feces of some cats; efficacy of the product was not adversely affected. HEARTGARD Chewables for Cats should be given at monthly intervals when mosquitoes potentially carrying infective heartworm larvae are active. The initial dose must be given within a month (30 days) after the cat’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the cat’s last exposure to mosquitoes. For optimal performance, HEARTGARD Chewables for Cats must be given once a month on or about the same date. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Chewables for Cats and resumption of the recommended dosing regimen will minimize the opportunity for development of adult heartworm. It is recommended that cats should be tested for existing heartworm infection prior to starting treatment with HEARTGARD Chewables for Cats. Cats already infected with adult heartworms can safely be given HEARTGARD Chewables for Cats monthly to prevent further infections. Monthly treatment with HEARTGARD Chewables for Cats also provides effective removal and control of adult and immature hookworms (A. tubaeforme and A. braziliense). SAFETY: In the clinical studies involving more than 3000 doses of HEARTGARD Chewables for Cats, observations reported within 24 hours of treatment included vomition in ≤ 0.3% and diarrhea in ≤ 0.2% of the doses administered. There were no statistical differences between HEARTGARD Chewables for Cats and the product vehicle (control) for these observations. A wide margin of safety was demonstrated in clinical trials at the recommended dose level in cats and kittens 6 weeks of age and older and in laboratory studies in cats with circulating microfilariae of D. immitis. A wide margin of safety has also been demonstrated at 3 times the recommended dose in pregnant or breeding queens and breeding toms. No adverse effects were observed in either male or female cats or their offspring in breeding studies. A 30-fold safety margin over the minimum recommended dosage was established in a single dose tolerance study. In growing kittens dosed monthly for 8 consecutive doses, one cat given 5 times the market dose vomited and a second cat in this group experienced diarrhea within 24 hours of the initial treatment. In clinical trials, many commonly used flea control products, anthelmintics, vaccines, antibiotics and steroid preparations were administered with HEARTGARD Chewables for Cats without incident. Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. STABILITY: HEARTGARD Chewables for Cats are stable for 2 years when stored below 77°F (25°C) and protected from light. Store at controlled room temperature of 68°F - 77°F (20°C - 25°C). Excursions between 59°F - 86°F (15°C - 30°C) are permitted. HOW SUPPLIED: HEARTGARD Chewables for Cats is available in two dosage strengths (see DOSAGE section) for cats of different weights. Each strength comes in a convenient carton of 6 chewables, packed 10 cartons per tray. For customer assistance, please contact Merial at 1-888-637-4251. 31 CHEWABLES CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS: For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense). DOSAGE: HEARTGARD® Plus (ivermectin/pyrantel) Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows: Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding on Foil-Backing and Carton Up to 25 26 - 50 51 - 100 1 1 1 68 mcg 136 mcg 272 mcg 57 mg 114 mg 227 mg Blue Green Brown HEARTGARD Plus is recommended for dogs 6 weeks of age and older. For dogs over 100 lb use the appropriate combination of these Chewables. ADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining Chewables to its box to protect the product from light. Because most dogs find HEARTGARD Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food.The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of HEARTGARD Plus must be given within a month (30 days) of the last dose of the former medication. If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the Chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Plus and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms. Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites. EFFICACY: HEARTGARD Plus Chewables, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. HEARTGARD Plus Chewables are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). ACCEPTABILITY: In acceptability and field trials, HEARTGARD Plus Chewables were shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs. PRECAUTIONS: All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. While some microfilariae may be killed by the ivermectin in HEARTGARD Plus at the recommended dose level, HEARTGARD Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae. Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans. Store at controlled room temperature of 68°F - 77°F (20°C - 25°C). Excursions between 59°F - 86°F (15°C - 30°C) are permitted. Protect product from light. ADVERSE REACTIONS: In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation. SAFETY: HEARTGARD Plus has been shown to be bioequivalent to HEARTGARD, with respect to the bioavailability of ivermectin. The dose regimens of HEARTGARD Plus and HEARTGARD are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. HEARTGARD demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of HEARTGARD products in dogs, including Collies, when used as recommended. HEARTGARD Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with HEARTGARD Plus in a heartworm disease prevention program. In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time. HOW SUPPLIED: HEARTGARD Plus is available in three dosage strengths (see DOSAGE section) for dogs of different weights. Each strength comes in convenient cartons of 6 and 12 Chewables. For customer assistance, please contact Merial at 1-888-637-4251. 32