October 2007 - TECHNION FOCUS MAGAZINE
Transcription
October 2007 - TECHNION FOCUS MAGAZINE
I n t e r n e t : h t t p : / / w w w . f o c u s . t e c h n i o n . a c . i l Technion—Israel Institute of Technology, Division of Public Affairs & Resource Development, October 2007 Year by year, through war and peace, challenges of immigration and innovation, Technion has been 60 times Israel’s devoted partner. Technion is delighted to greet the academic year with this diamond salute to celebrate 60 years since the establishment of the State. Decoding the Deep By Amanda Jaffe-Katz Published in Nature in September 2007, new recruit Dr Debbie Lindell and colleagues from MIT (Massachusetts Institute of Technology) were the first to record whole-genome expression of both a bacterium host and infecting virus over the course of infection. The researchers investigated the marine cyanobacterium Prochlorococcus—as host—and the phage P-SSP7, in the role of uninvited guest. Dr Debbie Lindell explores how a marine bacterium and infecting virus coexist. Yosi Shrem “Viruses turn their hosts into viral production factories.” By Amanda Jaffe-Katz “Water connects, water doesn’t divide,” said Dr András Szöllösi-Nagy, Director of UNESCO’s Division of Water, to the research members of the joint Palestinian, Jordanian, Israeli Project (PJIP) who convened at Technion’s Grand Water Research Institute (GWRI) in September 2007. “The ‘S’ in UNESCO stands for ‘science.’ You may feel like you are making a small step but it is a giant contribution,” he continued. continued on Page 6... A True Friend The summary meeting, chaired by Prof. Emeritus Josef Hagin, covered four years of research with the support of USAID-MERC— U.S. Agency for International Development Middle East Regional Cooperation Program. Even during periods of tension in the region, the intrepid researchers pursued their scientific goals without interruption. They met regularly in Israel, Cyprus, Greece and Turkey. “The project is exceptional in every way,” said Dr Adam Reinhart, the By Amanda Jaffe-Katz World-renowned nanoZisapel Nanoelectronics technology expert Sir Center Richard Friend, Cavendish Professor of Physics at Cambridge University, was the keynote speaker at the symposium, “New Era of Nano Devices,” at the inauguration of the Zisapel Nanoelectronics Center in May 2007. Friend, knighted by the Queen in 2003 for services to Physics, pioneered the study of organic polymers and revolutionized scientists’ understanding of the electronic properties of molecular semiconductors. His research is central to the development of flat panel displays and innovative foldable screens. Sir Richard shared some of his nanotechnology insights with FOCUS. continued on Page 3... Interview on Page 4... From the President “Water connects, water doesn’t divide.” T h e J e w i s h N e w Ye a r i s traditionally a time for individual and national reflection…an opportunity to translate our vision into action and deeds for the coming year. Technion is recognized as a key strategic asset for Israel, providing knowledge and personnel vital for the country’s academic and research Prof. Yitzhak Apeloig institutions and for a strong economy. Our vision is to be among the world’s top 10 scientific and technological research universities, and to that end, we continue to invest in new cutting-edge areas of education and research; to enlist the next generation of talented researchers and teachers as faculty members; and to attract the best students from Israel and abroad to pursue studies in our eighteen faculties of engineering, science, management, architecture, and medicine. Technion’s mission will only be realized through the active and devoted involvement of our academic community— faculty, students, and support staff; our partnership with our wonderful alumni and friends in Israel and abroad; and a strong commitment to higher education by the government of Israel. The Technion is encouraged by the recent recommendations of the government-appointed Shochat committee which includes an important set of proposals aimed to strengthen and reform the public funding of higher education. We urge the government to adopt a New Year’s resolution to fully implement these proposals, since Israel’s universities will be unable to meet the challenges ahead and maintain a high level of performance without a significant increase in government funding. This year Israel celebrates 60 years of sovereignty and independence. No other institution of learning has contributed as much to Israel’s success as has Technion— through basic and applied research, technological developments, and outstanding graduates, who have shaped Israel’s modern industry and in particular its world-leading high-tech sector which continues to amaze the technological world with its vitality and innovation. Much of Israel’s future is directly linked to Technion’s ability to meet the country’s ongoing needs. Indeed, the words of Israel’s first prime minister, David Ben-Gurion, remain as relevant today as in 1948, “widening the scope of the Technion’s research activities is an inestimable benefit to the current and future technological development of Israel.” We welcome the New Year with confidence and hope, and wish Technion’s faculty, students, staff, and friends around the world a year marked by happiness, prosperity, and peace. Mini Robot p.2 Yosi Shrem Water Talks The viral (phage) genome was linearly transcribed over the course of infection, lasting eight hours. The scientists noted that genes acquired by the phage from its hosts, including the photosynthesis genes and genes responsible for making DNA building blocks, were all transcribed at the same time, together with DNA Sea 2 Sky p.3 Nano Recruits p.5 Under the Sea pp.6-7 Summer Science p.8 I n n o v at i o n Business Bytes Biomedical Mann During its first six months of activity the Alfred E. Mann Institute for Biomedical Development at the Technion (AMIT) has been intensely active in research and development of its first project and in exploring new Technion innovations, which hold significant promise. The board of directors approved the move of the first project—a gastro-intestinal imaging device—to phase II and phase I funding was approved for a new tissue adhesive for wound closure and a new cardioprotective drug. AMIT was established in December 2006 to support the development and commercialization of innovative biomedical technologies from the Technion and is supported by a $100M endowment from the Alfred E. Mann Foundation for Biomedical Engineering. Mann intends to establish up to 12 Institutes in the United States, with AMIT the only one abroad. Peer Prizes PeerMobility took second place in BizTEC07, Technion’s annual entrepreneurship challenge. PeerMobility aims to implement a proximitybased communication middleware for BlueTooth and WiFi-enabled cellular phones. The PeerMobility team includes Vadim Drabkin, Gabi Kliot, and Prof. Roy Friedman from Technion’s Faculty of Computer Science. In the framework of their doctoral dissertations supervised by Friedman, the two students, together with Alon Karma, also developed WiPeer, the free software that connects computers without the need for an intermediary or Internet access. Since it was published, tens of thousands of users have downloaded WiPeer from the Internet. Modern Alchemy Viewpoint by Shlomo Maital Ancient alchemists thought everything was made of four elements— earth, air, fire, water. For centuries, they tried to turn base metals into gold—and failed. Modern alchemists tried to use earth, air, fire, and water to turn black tar into gold (oil)—and succeeded. These 21st century alchemists are Israeli. They are modern-era halutzim (pioneers) who spent years in frigid twenty-below weather in northern Alberta on a mission. The result may in the long run radically dilute the enormous strategic threat Arab oil enjoys, in Israel’s and the West’s favor. In the 1950s, the visionary David Ben-Gurion saw that Israel had no oil but lots of sunshine. So he asked Dr Zvi Tabor, who ran the National Physical Lab, to develop solar-powered water heaters. Today Israelis enjoy cheap hot showers as a result. A young French-educated new immigrant in the lab, Lucien (Yehuda) Bronicki, was then asked to design a turbine that could make electricity from solar-heated water. His small, tough turbines became the key product of his Yavne-based start-up company, Ormat, today a world leader in geothermal energy and low-maintenance turbines. Bronicki still runs the company with his wife, Dita. They own 27 percent of Ormat Industries Ltd. shares. In March 2007, they established the Bronica Entrepreneurship and Innovation Center at Technion in the Davidson Faculty of Industrial Engineering and Management. In September 2007, Dita and Yehuda appointed their son Yoram Bronicki as president of Ormat. Some experts say tar sands hold up to six trillion barrels of the world’s oil, half of all the remaining oil in the world, most of it in Alberta and Venezuela. But how do you get fluid gold from stuff that, according to Yoram Bronicki, “at room temperature, is as fluid as a highway”? Ormat sent Yoram, an engineer, to Cold Lake, Alberta, 300 km northeast of Edmonton, as the head of a team. Their Mission Impossible task: find a commercially viable way to produce oil from the Athabasca tar sands, in sub-zero weather. The stakes were high. Canadian tar sands hold proven oil reserves of at least 175 b. barrels, second only to Saudi Arabia’s 262 b. barrels, and by itself enough to supply all the world’s oil consumption for five whole years. In September 2007, the price of oil reached $82/bbl., before dropping back to around $80. In Cold Lake and in Yavne, Yoram and his team invented OrCrude™, an ingenious 3stage process that uses fire and water (steam), air and earth (tar) to separate and upgrade the ‘wheat’ (high-grade oil) from the ‘chaff’ (low-grade bitumen). Bronicki’s team demonstrated how to use some of the tar itself for energy to help turn the rest into fluid oil. Israeli exsoldiers, joined by Canadians, built and operated a pilot plant. Today a commercial plant is being built. Suncor Energy Inc. Yoav Bachar The bitumen-rich tar sands of Alberta, Canada PeerMobility team (l-r) Gabi Kliot, Vadim Drabkin and Prof. Roy Friedman Chinese Medicine Yoav Bachar As part of the initiative to rebuild Taizhou in Jiangsu Province as a Medical City to boost China’s pharmaceutical industry and establish a high-tech industrial park, representatives sought out Rappaport Faculty of Medicine’s Prof. Moussa Youdim. In a June 2007 visit to Technion, the Chinese professionals expressed an interest in collaboration with Youdim, professor of pharmacology. In October 2007, some 50 renowned international scientists came to Technion to celebrate Youdim’s 45 years in science. Colleagues and scientific collaborators from Israel, Europe, and North America discussed the latest research and clinical achievements in the 2-day symposium, “Recent Therapeutic Advances in Parkinson’s and Alzheimer’s Diseases.” Prof. Moussa Youdim (second from right) with Chinese professionals from Taizhou Medical City. Technion Focus October 2007 “Think global, act local,” we teach managers. While in Cold Lake, Yoram learned to act local—to skate and to play hockey. Canadian hockey great Wayne Gretzky had an uncanny ability on the ice to be in the right place at the right time. So do Israel’s global halutzim. Wherever there are business opportunities in the world, you will find Israelis. The new generation of pioneers will continue to make Israel an important global player. Shlomo Maital is Professor Emeritus at the Davidson Faculty of Industrial Engineering and Management, and serves as academic director of the Technion Institute of Management (TIM). World’s Smallest The world’s smallest autonomous robot—with a diameter of one millimeter— designed to travel through the bloodstream and deliver drugs has been created at Technion. Oded Salomon, a research engineer in the Faculty of Mechanical Engineering’s Kahn Medical Robotics Laboratory, conceived the tiny robot together with Prof. Moshe Shoham and Dr Nir Schwalb, a Technion alum of the lab and now a lecturer at the Ariel University Center.Their miniature “submarine” can negotiate the inner walls of blood vessels using tiny arms which will allow it to withstand blood pressure.The robot is powered by an external magnetic field allowing it to be controlled for an unlimited amount of time during medical procedures. A possible application could be for brachytherapy (short distance radiation therapy) which is commonly used to treat prostate cancer and cancers of the head and neck. Salomon said, “This accomplishment of miniaturization is without precedent, as is the ability to control the robot’s activity for unlimited periods of time, for any medical procedure. We hope this discovery can be used to improve the quality of care for diseases and many other conditions.” n e w s Vertical Flight Victory Honors A Technion Aerospace Engineering team at the 2007 Annual AHS/Industry/NASA Student Design Competition brought home top honors for the winning undergraduate project, Waterspout, a helicopter launched from a submarine. Sikorsky Aircraft Corp., the sponsor of the 24th competition, challenged participants to design an advanced deployable compact rotorcraft, capable of operating from a submersible vehicle, in support of Special Operations Forces. The Technion group, who teamed with Pennsylvania State University, comprised Mor Gilad, Lior Shani, Avida Schneller, Igor Teller, Elad Sinai, Rony Hachmon, and Avichai Elimelech, advised by Prof. Omri Rand, dean, and Chen Friedman, research engineer. The Technion students planned Waterspout’s mechanical deck, blade-folding mechanism, the submarine-helicopter interface, sealing solutions, and performed water-stability analysis. “This kind of project is a very important ingredient in the students’ education process,” explains Rand. “For them, it is a great opportunity to integrate all the various subjects that they have studied over four years. It is the first time they are given a description of what an aerial vehicle should do, and they have to produce a detailed design solution from scratch.” “Winning the first place in this competition puts our students and education system in the top league worldwide, which makes us very proud,” the dean says. Waterspout winning design The rotorcraft—a no-pilot helicopter—had to be operable in all global weather conditions, including arctic, maritime, tropical, and typical desert conditions. Uniquely, Waterspout is completely impermeable to water and can float in a rough sea. The autonomous vehicle takes off vertically and can make a 260 km nonstop flight to deploy or collect crew, even if injured. The innovative design allows the vehicle to exit through the submarine’s existing missile-silo hatch, while in periscope depth of 15 meters. The winning entry also features stealth technology. AHS International—The Vertical Flight Society is a professional society founded in 1943 that represents the interests of the worldwide vertical flight industry. http://www.vtol.org Water Silicone Savvy Prof. Yitzhak Apeloig, Technion president and member of the Schulich Faculty of Chemistry, was awarded the 2007 WACKER Silicone Award in recognition of his pioneering theoretical and experimental work in organosilicon chemistry. Apeloig is the first Israeli scientist to win this prize—an important international accolade in the field. “Thanks to his work on quantum chemistry, Yitzhak Apeloig has made an extraordinary contribution to the fundamental understanding of organosilicon chemistry,” said Wacker Chemie’s CEO, Dr Peter-Alexander Wacker. (l-r) Wacker President & CEO Dr Peter-Alexander Wacker, Prof. Yitzhak Apeloig, and Dr Christoph von Plotho, president of Wacker Silicones ...continued from Page 1 Yosi Shrem Quantum Leaps Participants in the joint Palestinian, Jordanian, Israeli Project (PJIP) from Technion’s Grand Water Research Institute; Ben-Gurion University of the Negev; Volcani Institute; Palestinian Research Group; Al Quds University; National Center for Agricultural Research and Technology Transfer (Jordan) Prof. Carlos Dosoretz project’s USAID scientific coordinator for the last four years. “Most of our projects are exceptional, but this is so even by our standards. Prof. Hagin is incredible—there should be 20 of him in every university! Technion’s scientific capacity is fantastic, and we are always hunting for more proposals from Technion,” he continued. Prof. Emeritus Uri Shamir, the founding director of GWRI, gave an overview of the PJIP from its inception Dr Woroud Awad of in 1995 as an initiative by him and supported by a Al Quds University foundation active in Israel with initial funds from the discusses wastewater treatment and reuse. British Technion Society, and later by the Beracha Foundation and most significantly by USAID. “We first met in Amman on November 19, 1995,” Shamir said. “We never lost the drive and expectation that the project is a platform for scientific progress and regional cooperation.” The project demonstrated the necessity for advanced tertiary membrane treatment of wastewater before it can be reused or discharged to the environment. Several types of secondary wastewater treatment produced treated wastewater for the membrane system including constructed wetland (CW); stabilization and oxidation ponds; and activated sludge. Introduction of membrane systems for wastewater purification on a larger scale will considerably improve the region’s irrigation water balance and environment. A senior member of the Palestine Research Group (PRG) spoke about the efficacy of CW in secondary wastewater treatment, recommending it as pre-treatment, particularly suitable for rural areas as little maintenance is required. He also spoke warmly of his appreciation for the cooperation from MERC and GWRI, and especially thanked Hagin. “Let’s hope for continuation of the project in Confocal microscopy picture of bio-film the future,” said Prof. Raphael Semiat, director on nano-filtration membrane of GWRI. Semiat, who also heads the Rabin Desalination Laboratory, gave a review of membrane systems. “I was at that first meeting in Amman. We didn’t know what would happen. I talked about membranes—others thought it too expensive, but now we see that membranes can contribute.” Membrane fouling was the main problem faced by the Jordanian researchers at the National Center for Agricultural Research and Technology Transfer (NCARTT). They tested membrane cleaning protocols at a pilot plant and concluded that, since the price of reclaimed water is quite expensive, it is not economical for small-scale agriculture. However, they decided to use this water on greenhouse crops to grow “very beautiful flowers,” Hagin confirmed. Physics Prof. Moti Segev received the 2007 EPS Quantum Electronics Prize, one of the top international awards in the field. The Quantum Electronics and Optics division of the European Physical Society awards two such prizes biennially—one for fundamental and one for applied aspects. Segev accepted the prize for applied aspects in Munich in June 2007, “for his outstanding and pioneering contributions in the field of light propagation in nonlinear media, in particular regarding spatial solitons in photorefractive materials, incoherent solitons, and nonlinear waves in periodic structures.” Earlier that same month, Segev received the Hershel Rich Technion Innovation Award. Young Investigator Dr Hossam Haick of the Wolfson Faculty of Chemical Engineering received the 2007 Bergmann Memorial Research Award from the United StatesIsrael BinationaI Science Foundation (BSF). Eligible investigators are recipients of newly awarded BSF grants who earned their doctoral degrees within the past five years, are not more than 35 years old on the date of submission, and whose project is of high scientific quality. King of the Road Transportation Minister Shaul Mofaz appointed Prof. Joseph Prashker from the Faculty of Civil and Environmental Engineering as Chief Scientist of the Ministry of Transport and Road Safety in May 2007. Prashker, a former head of the Transportation Research Institute at Technion, is an expert in transportation planning and engineering. Harvey 2 Be On March 17, 2008, Technion will award the 2007 Harvey Prize to Prof. Michael Grätzel, who directs the Laboratory of Photonics and Interfaces at the Ecole Polytechnique de Lausanne, and to Prof. Stephen E. Harris, Professor of Electrical Engineering and Professor of Applied Physics at Stanford University. The prestigious Harvey Prize, created as a bridge of goodwill between Israel and the nations of the world, is awarded annually to outstanding international scholars and scientists. It is considered a good predictor of the Nobel Prize, with 10 of its 63 recipients to date also winning the Nobel. Technion Focus October 2007 ...continued from Page 1 Q: What is your vision for nanotechnology? A: Opportunities lie in the convergence of different branches of science. Driven by a need to create an environment where things happen outside the regular framework, nanotechnology occurs when chemists need to work with physicists or biologists. Q: Which fields are important? A: They are diverse. There have been huge advances in tools and instrumentation. At Cambridge, we are aiming for new, useful things and a possible goal is large, cheap, functional structures. One major topic for the future is Energy, which covers issues such as solar cells, storage, batteries, and silica capacitors. Q: What is Technion’s standing in the nanotechnology world? A: Outside of Cambridge, and along with ETH-Zurich, Technion is right there. There is virtually a buzz about it. Two of Technion’s young faculty, Prof. Nir Tessler—an alumnus of Technion —and Dr Gitti Frey, conducted their postdoctoral research with me at the Cavendish Laboratory, so I can say that my past experience with Technion graduates is wonderful! Q: What is the significance of the newly dedicated Zisapel Nanoelectronics Center? A: New buildings are a response to a well-articulated vision. This remarkable building is a visible example of external support and also of the vitality of internal activities. The vision and desire to do good science has to come first, otherwise smart benefactors don’t respond with bricks and mortar.Technion has a wonderful program of science and engineering. Q: What does Nano mean to you? A: For me, nanotechnology is the bringing together of different areas of science and engineering to be able to exploit functionality. This we can define within a molecule or within a polymer chain by clever processing that puts it into a structure which will do something we find productive. What really makes this field interesting is the scope for new ways to make structures. Prof. Sir Richard Friend, keynote speaker at the “New Era of Nano Devices” symposium Yoav Bachar A True Friend Q: Can you tell us about your research into displays? A: The prototypical semiconducting polymer PPV (polyphenylene vinylene) is the ‘fruit-fly’ of light-emitting diodes. It is a highly colored, strongly fluorescent material. With PPV, we are not constrained to making small devices, closely packed together on a wafer of silicon, but we can literally paint or print wherever we want. The current challenge is to generalize the concept of ink from ‘that stuff that leaves marks on paper’ to functional materials. Ink, therefore, now means semiconductor, and polymer disposition can be achieved by inkjet printing. A single pass with a 3-color printer makes a full color display. Q: What will you lecture about today? A: I call my talk “Plastic Electronics” and I offer a tour through the science and engineering of what can be done with polymers which have semiconducting properties—materials that were not traditionally regarded as part of semiconductors. This raises an interesting question: “Is this nanotechnology?” Q: What does nanotechnology hold in store for industry? A: For me, this is practical nanotechnology: if you like, this is functionality bottled up with a single molecule, or in our case, a polymer chain, allied with novel ways of manufacturing. Because, in the end, it is manufacturing that makes the difference—that’s what causes industries to happen. Far more sophisticated control of structure is absolutely possible, and that will take the field further into the future. Super Cluster Bach’s Remedy Performance issues include concurrency, the ability to perform actions simultaneously; scalability, where performance is not impaired by increasing the number of processors; and locality, where there is a high ratio of local memory accesses to remote memory accesses. “NANCO is a batch computing environment, wherein you create a job that you wish to run (using your code or a prebuilt application), submit that job to the system to be scheduled to run at a later time, and get your results upon completion,” says Weill-Zrahia of the Taub Computer Center. She is in charge of High Performance Computing (HPC) and her mandate now extends to parallel programming on NANCO. At the design stage, she characterized the most popular applications to be run on the newly acquired supercomputer, the expected workload, and translated this information into architecture specifications, system management and software tools for developers. “We expect there will be dozens of users,” says Dr Joan Adler of the Faculty of Physics and a member of the academic committee for the supercomputer. http://phycomp.technion.ac.il/~NANCO/ A A novel, reusable, nano water purification method By Barbara Frank ltai Bach already knew that he wanted to do his PhD in water research when, at the end of his undergraduate studies, he met Chemical Engineering Prof. Raphael Semiat, director of the Grand Water Research Institute. Bach’s interest in understanding processes initially attracted him to the field of Chemical Engineering, and water research fits in with his overall interest in ecology. Semiat’s notion to use nanoparticles to purify wastewater sounded like a fulfilling research project. Bach explains, “It is understood that we need to find novel solutions to water sources. Wastewater purification is practical, affordable and ecologically friendly— available wastewater should be purified everywhere.” Together with Semiat and Dr Grigory Zelmanov, a researcher in the Rabin Desalination Laboratory, Bach is researching a new process for wastewater purification good for both industrial wastewater and partially treated municipal sewage. Their revolutionary method uses nanoparticles as catalysts to destroy the organic compounds in wastewater. Most organic materials are made of carbon and hydrogen. With an oxidizing agent, the nanoparticles decompose the organic content so what remains is just carbon dioxide and more water. Importantly, the nanoparticles can be separated from the water without leaving any residue and can be used again. The researchers have actually worked on two different processes, now patented, and are looking to commercialize TEM capture of iron nanoparticles with their groundbreaking research. The paper outlining Bach’s work 200 ppm concentration.The nanoparticles is published in the October 2007 issue of the journal, Water catalyze the purification reaction. Research. Within the published scientific community, Bach says, “we are the first to use nanoparticles derived from different kinds of metals to purify wastewater at affordable low cost.” This method is very effective and the oxidation process is greatly speeded up in comparison with existing technologies. The first stage is to adsorb the organic matter on an adsorbent like active carbon, loaded with the proposed catalyst. This purifies the water from the dissolved organic matter. The nanoparticles are then put to work with an oxidant, destroying all the organic compounds and recovering the adsorbent. The water can then be made suitable for any purpose: from crop irrigation to drinking water, or any other use. The current industrial process to recover the active carbon filter after it becomes saturated with the organic material involves a high energy-consuming process (at least 800°C), or the filter has to be destroyed. The proposed technique is simple to operate and consumes no energy, except for pumping the water. The active carbon filters may be reused in place again and again. Bach, 30, is married to Orit, a Technion Chemical Engineering graduate now pursuing a career in her field with the Israeli Air Force. Research is conducted in the Wolfson Faculty of Chemical Engineering, the Grand Water Research Institute, and the Rabin Desalination Laboratory. Technion Focus October 2007 PhD student Altai Bach uses nanoparticles to purify wastewater. Yosi Shrem By Amanda Jaffe-Katz With the advent of new research fields such as nanotechnology, the need for high performance computing has become more acute. Requisite resources include large memory, high floating point computing speed, and high data throughput. A new, advanced supercluster computer purchased by the Russell Berrie Nanotechnology Institute (RBNI)—dubbed NANCO—will meet these requirements. “We are looking for ways to improve performance,” says Dr Anne Weill-Zrahia, a well-known expert in parallel computing, in her 4-hour NANCO introductory course offered to all Technion students, faculty and staff as well as potential users from outside the Technion. The RBNI-sponsored July 2007 workshop covered the basics of parallel computing and orientation on NANCO, job submission, and basic MPI (a language permitting the writing of parallel codes). Participants came from Chemical Engineering, Physics, Mechanical Engineering, Biomedical Engineering, Electrical Engineering and Biology. T Coming Soon... Dr Nano he first PhD student in the Norman Seiden Multidisciplinary Program for Nanoscience and Nanotechnology is Polina Pine. She is researching atomistic simulations of single-walled carbon nanotube oscillators. Carbon nanotubes are long, thin tubes made from rolled-up single sheets of graphite, and can be grown in lengths ranging from a few nanometers to hundreds of microns. “Experiments at the nanoscale are much harder to carry out than experiments at longer length scales,” says Pine and she explains that, conversely, simulations at the nanoscale are much easier to perform than simulations at longer length scales. Nano-Electro-Mechanical Systems (NEMS) based on nanotubes have enormous potential in diverse applications, from ultra-sensitive mass spectrometers that can be used to detect hazardous molecules, through biological applications at the level of a single DNA base-pair, to the study of fundamental questions such as the interaction of a single pair of molecules. Pine’s simulations will help scientists understand the underlying physics of such NEMS. “From nanotubes to novel device applications.” “Paulina’s project, which paves the road from fundamental understanding of carbon nanotubes to novel device applications, is typical of the multidisciplinary nature of the program,” says Prof. Yachin Cohen, program head. “It is a very interesting theme,” says Pine. “I am specializing in carbon nanotube sensors. I presented a poster on this at the June 2007 Summer School on ‘Women-in-nano: Career Development and Research Trends’ in Tarragona, Spain.” The European Commission-funded school provided opportunities for networking, establishing mentoring schemes and promoting contact among experts from European universities, science institutions and industry. Pine’s toddler daughter accompanied her to Spain, causing fellow participants—women students but also male lecturers— to joke that she was already educating the next generation of women in nano. “I was also asked to participate at a Round Table session on how to achieve a satisfactory work-life balance. I found it interesting that there is a tradition in Europe of women in science, and they enjoy a large network of support there,” Pine comments. With two degrees already from Technion—in Biochemistry and Chemistry—Pine is now jointly supervised by Dr Joan Adler in the Faculty of Physics and by Dr Yuval Yaish from the Faculty of Electrical Engineering. Between graduate degrees, Pine worked at Applied Materials in Rehovot. After completing her doctorate, she would like to stay in academia. Pine came alone to Israel from Russia on a special program for youngsters. “I always say, when people ask where I am from, ‘Technion is my home in Israel.’” “The Russell Berrie Nanotechnology Institute offers a very friendly program,” Pine says. “It gives people from many different areas the chance to sniff out what is going on in other areas.” It seems that Pine isn’t the only one to think so: this year’s exclusive enrollment has doubled, and there are to be seven PhD and 25 MSc students in the program, selected out of hundreds of applicants. Computational nanoelectronics pioneer, PhD student Polina Pine, unravels her poster on carbon nanotube sensors. Yosi Shrem Stories By Amanda Jaffe-Katz The Nano Generation “It is illustrative of the incredible vitality of the Zisapel Nanoelectronics Center,” announced Electrical Engineering Prof. Joseph Salzman in May, “inaugurated just this morning, and already we have notification that the first workshop in the 3-year training series—ProMiNaS—will be at Technion. This is the first international recognition of the Zisapel Center.” ProMiNaS (Prototyping in the Micro and the Nano Scale) offers hands-on laboratory courses in the area of Micro- and Nanotechnology to train young researchers in the experimental tools needed to close the gap between conventional microelectronics— its technologies and materials, and the novel, exotic and possibly contaminating materials and systems in nanoelectronics. Financed by the European Union (€600,000) as part of the Marie Curie Conferences and Training Courses, the six scheduled courses plus a final 3-day workshop take place at Technion, the Institute of Photonics and Nanotechnology (IFN-CNR) in Rome, and the Département de Recherche sur la Matière Condensée, CEA Grenoble, France. The July 2007 course, held at Technion, addressed Basic Microelectronic Processing. Participants are early in their research careers, either advanced PhD students, postdoctoral researchers, or young engineers. The interesting aspect, Salzman says, is their diversity in background discipline. They come from chemistry departments, electronics, physics and optics and therefore the course provides some aspects that are foreign to them, far removed from their previous experience. Selection criteria are based on excellence, eventual benefit, motivation, and a letter of recommendation. Other considerations came into play such as maintaining a 50-50 male-female ratio, and limiting participation to three attendees per country. “We received some 60 Yoav Bachar International participants at the ProMiNaS workshop gain hands-on experience at Technion’s state-of-the-art clean-rooms in the Zisapel Nanoelectronics and Wolfson Microelectronics facilities. outstanding applications and chose the 12 best. We expect that half will continue to become university professors or heads of research labs,” says Salzman. Salzman is in charge of the Zisapel Nanoelectronics and Wolfson Microelectronics complex. Two years ago, as head of the microelectronics research center, he resolved that the clean rooms would become a semi-independent unit, known as the MNFU (Micro Nano Fabrication Unit), with independent budget and management. Nanotechnology, in Salzmann’s view, represents a manufacturing revolution. “It is not merely a case of micro made smaller. Nano is all about innovation: new materials, methods, and approaches,” he says. “Nanotechnology represents a manufacturing revolution.” “I believe there is a Nano-Micro-Macro continuum,” Salzman says. “Assuming you have some device or object which is the size of a few molecules—very, very small— and assuming you want to do something to it and measure this, you need contact with the external world. Even in the nano dimension you have to go through the micro scale for contact with the outside world.” Each morning the 12-day course started with a 2-hour lecture covering the theoretical background of that day’s lab work. Then, participants rotated among three parallel lab sessions, instructed by Technion PhD students. Each of the many specialized machines in the MNFU facility represents a discipline in science. Topics included photolithography for small-scale patterning; carving with the etching apparatus; metallization; and oxidation. Altogether, the participants received 25 hours of frontal lectures and 40 hours hands-on in the clean room. Participants included Felix Martinez, a postdoctoral scholar from Cartagena, a city on Spain’s southern coast. “Technion is such a beautiful campus,” he said. “The smell of the pine trees here reminds me of the Mediterranean.” Other attendees came from Malaysia, Romania, Turkey, France, Italy, UK, and Germany. The second ProMiNaS course, held in Rome in October 2007, addressed Single Electron Transistors and Photonic Crystals. Those participants who had previously attended the Technion course benefited from the basic skills they had gained in Clean Room work. “With the diversity, capabilities, and brains we have in our academic institutions, we must continue this international collaboration to disseminate the interdisciplinary aspects of nanotechnology and to educate future engineers and researchers in the new emerging fields of high technology. It is our hope that others will follow this effort to materialize nanotechnology know-how,” Salzman concluded. Technion Focus October 2007 u n d e r t h e s e a Science of the Oceans P By Amanda Jaffe-Katz rof. Oded Béjà of the Faculty of Biology is a world leader in the burgeoning research discipline of environmental genomics. This exciting field, also known as microbial ecogenomics or metagenomics, explores parts of the ocean that were, until recently, hidden from us. Béjà’s mandate is, “To illuminate the role of microorganisms in the open seas,” and to that end his lab uses innovative molecular biology techniques, along with functional genomics and bioinformatics. Prof. Oded Béjà tests the waters in the Dead Sea. Recently, Béjà has been taking a close look at photosynthesizing genes in a virus that attack cyanobacteria that live in the sea. These bacteria—named for their blue color, cyan—obtain their energy through photosynthesis. The discovery of such genes in the genomes of the virus (or phage) that infect these cyanobacteria suggests new paradigms for the regulation, function and evolution of photosynthesis in the vast ecosystem of the open sea [see accompanying story on Dr Debbie Lindell’s research]. Revolutionary findings related to this viral photosynthesis directly from natural ocean samples were published online by Béjà in August 2007 in the ISME Journal: Multidisciplinary Journal of Microbial Ecology, a new journal issued by the Nature Publishing Group. “Using environmental genomics we show that about 60 percent of the psbA genes (photosynthesis genes coding for the D1 protein) in surface waters in the oceans are of viral origin,” said Béjà. “Furthermore, we show that different viral psbA genes are expressed in the environment.” To put the significance of this research into perspective, Béjà says, “Fifty percent of photosynthesis in the world is done in the sea, and 50 percent of this is done by cyanobacteria.” Béjà’s research analyzes, directly in the environment, cyanobacteria of the Synechococcus and Prochlorococcus types, both important contributors to photosynthetic productivity in the open ocean. Moreover, the large amounts of oxygen in the atmosphere were likely first created by the activities of ancient cyanobacteria. “To illuminate the role of microorganisms in the open seas.” The most critical protein in photosynthesis, D1, is a scaffold on which everything sits. It suffers from photo-damage, and requires turnover. “We found that some of the viruses that attack cyanobacteria contain modified D1 protein” Béjà explains. The researchers showed that the phage genes are undergoing an independent selection for distinct D1 proteins. Furthermore, the D1 found in the virus is slightly different from that of its bacterial host. This anomaly is found on one of the loops, and probably makes it more stable to degradation. The Technion team and their colleagues are exploring the changes in the function of the expressed D1 gene as it passes from the cyanobacteria to the virus and back again. “My hope is to find the role of this photosynthesis protein in the virus,” Béjà says, “to prove that this process does occur in the ocean—and in measurable quantities.” The Technion team includes researchers in the Faculties of Biology, Chemistry, and DNA linguistics and bioinformatics experts from the Lokey Interdisciplinary Center for Life Sciences and Engineering. A co-author on the paper is J. Craig Venter, who held a pivotal role in the Human Genome Project. Prof. Oded Béjà received the 2007 Henry Taub Prize for Academic Excellence for his predominant role in establishing the new research field of Environmental Genomics. Decoding ...continued from Page 1 replication genes, even though this meant that some were expressed out-of-sequence. The researchers hypothesize that the bacterial-like genes form a functional module that help the phage obtain sufficient energy for DNA replication. A unique finding among phage–host interactions was the up-regulation of about 40 host genes—as opposed to total shutdown during infection. Intriguingly, many of these upregulated genes were transferred to the host from phages. Lindell explains, “These results show that genes transferred between hosts and phages are expressed in the recipient organism suggesting that on evolutionary scales, the exchange of genes between host and virus is beneficial to both organisms for life in the ocean, even though individual infected bacteria may die.” “I always liked water, the sea, and diving,” says Lindell, now a leading researcher in the field of marine microbial ecology who grew up in Melbourne, Australia. “I am interested in the effects of environmental factors on the physiology of marine microorganisms and how, in turn, this impacts their population dynamics, diversity and evolution.” Her research focuses on marine cyanobacteria—aquatic bacteria that photosynthesize (gobble up light for energy). “Cyanobacteria are a major component of the phytoplankton which produce approximately 50 percent of the world’s oxygen and are the basis of the oceanic food web,” says Lindell. They play an important role in reducing the level of atmospheric carbon dioxide which they use to make organic carbon, helping to ease the effect of this gas on global climate change. “Without them, the oceans—and the world—would look quite different.” “Without cyanobacteria, the world would look quite different.” Lindell studies the interactions between cyanobacterial hosts and their viruses, analyzing how these interactions impact cyanobacteria at the ecological, physiological and evolutionary levels. Viruses can’t reproduce outside of another organism, and their Phage Fast Facts • • • • Viruses that infect bacteria are called bacteriophages (phages) Phages are the most abundant biological organisms in the oceans Viruses can only reproduce inside a host organism Viruses act as a reservoir of genes transferable between species Technion Focus October 2007 specialty is to turn their cellular hosts into viral production factories. “While we understand how this happens in a few model laboratory host–phage systems, our understanding of this process in environmentally relevant host–virus systems is practically nonexistent. I envisage that I’ll be studying these interactions over the next 10 years or so in order to better understand the impact phages have on the ecology and evolution of their hosts,” she Dr Debbie Lindell regularly samples the water in says. the Red Sea and will begin a sampling program in Lindell joined the Technion’s the Mediterranean Sea shortly. Faculty of Biology in October 2006, after a postdoctoral appointment at MIT. Research carried out by Lindell and colleagues at MIT and published in PNAS in 2004, showed the existence of photosynthesis genes in the genomes of several phages that infect Prochlorococcus. “This surprising finding prompted me to change the focus of my research temporarily,” Lindell says. “I wanted to know what the phages are doing with those genes—did they get them from the host? Are they functional in photosynthesis during infection? Do they confer a fitness advantage to the phage?” “This was not just a fluke event. A full 80 percent of cultured cyanobacterial viruses that we observed have these genes,” says Lindell, “and viral photosynthesis genes are extremely abundant in the environment” [see accompanying story on Prof. Oded Béjà’s research]. While the virus hijacks the cell to ensure its own reproduction, it seems to need photosynthesis to continue for a little longer. These viral genes are expressed during infection and may augment photosynthesis during this time, giving the phage an extra energy boost to enhance its reproduction. This hypothesis still needs to be tested experimentally. Host–virus systems play a significant evolutionary role by facilitating gene transfer between species. “The impact of gene transfer mediated by phages is a hot topic in microbiology as we are coming to realize the pivotal role phages have played in shaping the genomes of their hosts,” Lindell concludes. Dr Debbie Lindell is a recipient of the Marie Curie Reintegration Grant from the European Union, the Legacy Heritage Fund grant (Morasha) from the Israel Science Foundation, the Alon Fellowship from the Council for Higher Education, and the Technion’s Mallat Family Fund and Robert J. Shillman Career Advancement Chair. Micro Miracle A How an invertebrate masters the art of body building Sea squirts (also called “tunicates” after their tough outer tunic) are widely distributed in shallow coastal waters, including along Israel’s Mediterranean coast, as colonies of genetically identical individuals called “zooids.” lthough the ability to grow a whole new body from a fragment is typically restricted to simple life forms such as sponges, worms, and jellyfish, “Massive regeneration is not just confined to low-complexity animals but can take place in highly evolved animals, too,” according to Dr Ram Reshef of Technion’s Faculty of Biology. Investigating the phenomenon in our closest invertebrate relative, the sea squirt Botrylloides leachi, Reshef, his PhD student Yuval Rinkevich, and colleagues, shed light on the molecular signals underlying the squirt’s whole body regeneration (WBR). In a process resembling the early stages of embryonic development, an adult sea squirt can be reconstructed from a miniscule blood vessel fragment in as little as 10 days. The results were published in April 2007 in the journal PLoS Biology. “Stem cells culminate in an entire organism.” The scientists reported the unique way in which the squirt achieves WBR. “When less complex groups regenerate their bodies, they do so through what we call a blastema, which is a kind of tissue that forms right at the place where you want to regenerate an organ or body,” Reshef said. The sea squirts, however, did not employ blastemas. Rather, regeneration began from dozens of tiny compartments loaded with stem cells, which the researchers dubbed regeneration niches. “In mammals, many adult organs and tissues contain specific stem cells that are involved in repair and some restricted regeneration abilities,” Reshef said. “The huge difference here is that the stem cells culminate in an entire organism.” The researchers found that the addition of retinoic acid (RA, a vitamin A derivate) regulates diverse developmental aspects in WBR. The sea squirt’s WBR process could serve as a new in vivo model system for regeneration, suggesting that RA signaling may have had ancestral roles in body restoration events, the scientists concluded. Improve Your Image Electrical Engineering graduate student Tali Treibitz is lucky to be able to combine work with pleasure. Treibitz is a scuba diving instructor, a skill which turned out to be a prerequisite for her PhD research on “Recovering Visibility in Scattering Media under Artificial Illumination.” Treibitz’s research, which is conducted under the guidance of Dr Yoav Schechner, involves complex diving skills and special equipment: a camera, light source, a tripod with added weights, and photography accessories, as well as a lift bag, a unique device used to lift heavy objects from the ocean floor. Treibitz graduated from the Faculty of Computer Science in 2001 in the Chais Program for Exceptionally Gifted Students. Later she worked in the high-tech industry, and traveled abroad for a year—a trip that happily included many scuba dives—before she returned to the Technion to start graduate studies. While searching for a research topic, Treibitz was immediately drawn to research integrating computer vision, photography and physical effects. When she discovered Schechner’s research on creating solutions to imaging problems in scattering media— media containing light scattering particles—she knew the match had been made. Her work also has defense-related applications, and can address port and ship inspection, aerial imaging and more. “A clear picture, with better visibility and contrast.” Treibitz’s doctoral research deals with solutions to problems that arise when imaging in scattering media under artificial illumination. “My work is related to vision though water, haze, or fog,” says Treibitz. Her current work is to develop methods for underwater visibility enhancement. She will soon advance from processing underwater stills to solving issues related to underwater videos. “Every underwater photo suffers from light scattering and light absorption problems,” Treibitz explains. “But in photography that utilizes artificial light—as opposed to photography under natural illumination—light scattering problems are much more severe because of the powerful light source used. Since water is a type of Backscatter greatly degrades visibility: A raw underwater image taken with artificial illumination. scattering medium, its particles scatter light into the camera. These reflections (termed backscatter) ‘take over’ the Tali Treibitz dives with tripod picture—and we end up seeing and lift bag in the Red Sea. the light beam in the picture, instead of the imaged object.” She continues, “In order to decrease the influence of the backscatter in photography, we use a polarized light source. First, the picture is partially ‘cleaned up’ by mounting a polarizer on the camera. The mounted polarizer blocks part of the partially polarized backscatter, whereas reflected light from the object is less polarized and thus passes through the polarizer. We have developed a way to make the beam disappear in a more significant manner. This is done by taking two images of the same scene, with two different polarization states, and then post-processing the image pair. Our approach results in a clear picture, with better visibility and contrast.” Treibitz presented “Instant 3Descatter” at the IEEE Computer Society Conference on Computer Vision and Pattern Recognition, IEEE CVPR, in 2006. Treibitz and Schechner have recently started international scientific collaboration with researchers at the University of Miami and Woods Hole Oceanographic Institution. Dr Yoav Schechner joined the Technion’s Faculty of Electrical Engineering in 2002 as a Landau Fellow in the Leaders in Science and Technology Program. The result of Tali Treibitz’s method—the restored imaged object, without backscatter. Technion Focus October 2007 Outreach People of the Book An impressive bronze sculpture, Books and the Written Word, stands tall in Kislak Park at the center of the Technion campus—an inspiration to all students. As can be seen in the photograph, it depicts a book from which letters in various alphabets emerge.The majestic oeuvre was dedicated in the presence of the donor, entrepreneur Leonid Raiz, his wife Alexandra, the world-renowned sculptor Boris Zaborov, and architects Shaul Kaner and Michael Seltser. “This is a fitting monument to the importance of the book to Jews—the People of the Book,” said Zaborov who was born in Minsk and, since 1980, lives and works in Paris. Raiz immigrated to the USA in 1980 from the former Soviet Union. He became involved in the application of computers for design automation and developed highly successful computerized software for architectural design that is now used worldwide. Chemistry Olympics Two members of the Israeli team, Assaf Shapira and Itamar Shamai, won Silver and Bronze medals at this year’s International Chemistry Olympics held in July 2007 in Moscow and attended by representatives from 72 countries. Coached by members of Technion’s Schulich Faculty of Chemistry, four Israeli participants made it to the international finals from among the 6,000 first-stage 11th- and 12thgrade contestants. National winners earn exemption from their Chemistry matriculation exams along with a grade of 100 percent, and free first year tuition at Technion. The team was accompanied to the competition by Prof. Moris Eisen and Dr Iris Barzilai. Silver medalist Assaf Shapira does lab work in Moscow at the International Chemistry Olympics. Shapira is a 12th-grader at Haifa’s Hugim High School, where Nobel Laureate in Chemistry Technion Distinguished Prof. Aaron Ciechanover was a student. Girl on the Moon “Would you want to return to the moon?” 14-year-old Rami asked former astronaut Neil Armstrong, the first man to land on the moon almost exactly 38 years ago. “Of course,” Armstrong replied, on his first ever visit to Israel, and asked the youngster if he would like to come along. This was one of many moving moments experienced by some 100 youngsters, who came to MadaTech—Israel National Museum of Science, Technology & Space to get a first-hand glimpse of the man who made history. In Israel at the invitation of the Direct Investment House, a relaxed Neil Armstrong, aged 77 and exuding tremendous vitality, answered a range of personal and professional questions that were asked in Hebrew, Arabic and English. Armstrong’s advice for those children who might want to be astronauts one day: “A very good education, particularly in the fields of science and mathematics.” Armstrong visited the Museum’s display on Ilan Ramon, Israel’s first astronaut, who lost his life in the Columbia space shuttle crash. The exhibit combines Ramon’s personal items with explanations on scientific experiments Ramon conducted in space—one of which was instigated by a group of school students under Technion supervision. Asked about the lasting value of space flights, Armstrong explained that “they demonstrate that we humans will not be forever chained to planet Earth.” Reminiscent of Albert Einstein’s 1923 planting of a palm tree here— the original Technion campus—Armstrong planted a tree fronting the Einstein Exhibition Hall. (l-r) Californians Laura Scharff and Aryeh Canter take samples at the constructed wetlands pilot site to assess how aquatic plants can reduce industrial contaminants in wastewater. Prime Numba The first campus summer program in number theory, dubbed TOMBA, took place in August 2007. The 25 outstanding 9th- to 12th-graders selected by the academic committee were divided into groups of three, each group supervised by a Technion student. Number theory is a classical field of mathematics which deals with the exploration of properties of the natural numbers with which we are so familiar: 1, 2, 3, 4, 5… The 2week program also included social and recreational activities, as well as advanced lectures by researchers in number theory, open to the general public. TOMBA also presents an opportunity to integrate talented— but socioeconomically challenged— students into the scientific world. Dr Yossi Cohen, Prof. Moshe Baruch and Prof. Jack Sonn initiated and organized TOMBA with the help of the Faculty of Mathematics. “They are competing for a $5,000 prize from World ORT, which will be awarded at the end of the camp to the boy or girl who solved the greatest number of problems in the best way, but also helped others find solutions. We are pleased to see that aside from the studies, a real social experience has been created and we hope to see them at the Technion in future years,” says Cohen. Gustavo Hochman Yosi Shrem In August 2007, 68 students attended Technion’s international 3-week science and technology summer research program, SciTech—now in its 16th year. The 55 international participants included 11th- and 12th-grade students from Bulgaria, Canada, Hungary, Italy, Poland, UK and the USA. The youngsters chosen are those who have shown an exceptional interest and ability in science and technology. They conduct research projects on campus, guided by Technion staff. This year’s SciTech winning presentations and posters covered diverse topics such as Human Embryonic Stem Cell Derived Cardiomyocytes, Hand Gesticulation Recognition, Re–Presenting the Urban Image, and Creating 3D Video. Shlomo Shoham Summer Science Solving mathematical problems: Participants at Technion’s Number Theory Summer Camp (TOMBA). Technion FOCUS is published by the Division of Public Affairs and Resource Development Technion-Israel Institute of Technology, Technion City, Haifa 32000 Israel Tel: 972-4-829-2578 [email protected] www.focus.technion.ac.il VP Resource Development and External Relations: Prof. Peretz Lavie Director, Public Affairs and Resource Development: Shimon Arbel Head, Department of Public Affairs: Yvette Gershon Editors: Amanda Jaffe-Katz, Barbara Frank Photo Coordinator: Hilda Favel Design: www.vistaspinner.com Technion Focus October 2007