Front Matter - Circulation Research
Transcription
Front Matter - Circulation Research
Volume 70, Number 6 June 1992 Circulation Reseairk American Heart Association 73-5102 ISSN 0009-7330 Konlgsberg Instruments' P-series miniature implantable pressure transducers are the acknowledged gold standard of the Industry. Triton Technology's pressure amplifiers and dP/dt modules are designed to function specifically with these giauges. Used In conjunction with Triton's Sonomicrometers and ultrasonic fiowmeters, they constitute the most powerful cardiovascular mechanics measurement system available. When your physiological monitoring requirements call for the most accurate, stable measurement of blood pressure, don't settle for less than premium Konlgsberg transducers, In stock exclusively from Triton Technology, Inc. ; 4h >'^gNUiiNC~~I~Th Volume 70, Number 6 June 1992 l Circulation Research ORIGINAL CONTRIBUTIONS Novel Diazinone Derivatives Separate Myofilament Ca2' Sensitization and Phosphodiesterase III Inhibitory Effects in Guinea Pig Myocardium Carlo Ventura, Redonda Miller, Hans-Peter Wolf, Norbert Beier, Rochus Jonas, Michael Klockow, Inge Lues, Osamu Hano, Harold A. Spurgeon, Edward G. Lakatta, and Maurizio C. Capogrossi .... Effect of Cyclooxygenase Blockade on Blood Flow Through Well-Developed Coronary Collateral Vessels John Altman, Daniel Dulas, and Robert J. Bache ............................................ Antioxidant Effects of Calcium Channel Blockers Against Free Radical Injury in Endothelial Cells: Correlation of Protection With Preservation of Glutathione Levels I. Tong Mak, Patricia Boehme, and William B. Weglicki ...................................... Electrical Field Stimulation-Mediated Relaxation of Rabbit Middle Cerebral Artery: Evidence of a Cholinergic Endothelium-Dependent Component Dee A. Van Riper and John A. Bevan ...................................................... Redistribution of Red Blood Cell Flow in Microcirculatory Networks by Hemodilution A.R Pries, A. Fritzsche, K. Ley, and P. Gaehtgens ........................................... ax-Adrenoreceptor Blockade Reduces the Angiotensin II-Induced Vascular Smooth Muscle Cell DNA Synthesis in the Rat Thoracic Aorta and Carotid Artery Ellen M van Kleef, Jos F.M. Smits, Jo G.R De Mey, Jacques P.M. Cleutjens, Donna M. Lombardi Stephen M. Schwartz, and Mat J.A.P. Daemen ............................................... Heparin Inhibits the Expression of Tissue-Type Plasminogen Activator by Smooth Muscle Cells in Injured Rat Carotid Artery Alexander W Clowes, Monika M. Clowes, Thomas R. Kirkman, Christopher L. Jackson, YP. Tina Au, and Richard Kenagy ........................ ............................................. Energy Metabolism and Contractile Function After 15 Beats of Moderate Myocardial Ischemia Andrew E. Arai George A. Pantel,, William J. Thoma, Cheryl G. Anselone, and J. David Bristow ...... Adenosine Release and High Energy Phosphates in Intact Dog Hearts During Norepinephrine Infusion Mark W Gorman, Xue-Han Ning, Miao-Xiang He, Michael A. Portman, and Harvey V Sparks ..... Acceleration of Recombinant Tissue-Type Plasminogen Activator-Induced Reperfusion and Prevention of Reocclusion by Recombinant Antistasin, a Selective Factor Xa Inhibitor, in a Canine Model of Femoral Arterial Thrombosis Michael J. Mellott, Marie A. Holahan, Joseph J. Lynch, George P. Vlasuk, and Christopher T. Dunwiddie ............... ............................................. Lysoplasmenylethanolamine Accumulation in Ischemic/Reperfused Isolated Fatty AcidPerfused Hearts Norman J. Davies, Richard Schulz, Peter M. Olley, Kenneth D. Strynadka, Donna L. Panas, and Gary D. Lopaschuk . ................................................................ Right Ventricular Preload Recruitable Stroke Work, End-Systolic Pressure-Volume, and dP/dtmaxEnd-Diastolic Volume Relations Compared as Indexes of Right Ventricular Contractile Performance in Conscious Dogs Mohanraj K. Karunanithi Jerzy Michniewicz, Susan E. Copeland, and Michael P. Feneley ..... ..... Relation Between Glycolysis and Calcium Homeostasis in Postischemic Myocardium Richmond W Jeremy, Yukihiro Koretsune, Eduardo Marban, and Lewis C. Becker ..... ........... 1081 1091 1099 1104 1113 1122 1128 1137 1146 1152 1161 1169 1180 CIRCULATION RESEARCH (ISSN 0009-7330) is published monthly by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231-4596. For rates in Japan, contact Nankodo Co., Ltd., 42-6 Hongo 3-chome, Bunkyo-ku, Tokyo 113, Japan. In the United States, individuals may subscribe for their personal use at the following annual rates: $122 for members of an American Heart Association scientific council and $152 for nonmembers. Outside the United States, add $60 for postage. Contact AHA for single copy rates and subscription rates for medical professionals in training and for libraries, reading rooms, and other multiple-use institutions. Second class postage paid at Dallas, Texas, and additional mailing offices. POSTMASTER: Send address changes to CIRCULATION RESEARCH, American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231-4596. Al American Journal Of Physiology: Heart and Physiology Circulatory g l l l l l ll | 11 w l l w l l lEditor: Sciciltists interested in the physiology of the heart, blood vessels, anid lymphatics will finid str'ingenitly reviewed, cutin-edg,e orig'inal researchi the Auericauinjonirnal of Pliys iolo),y: I-art anid Circnlatory PIiysioIQg. Experii-miental and theoretical st udies of cardiovascular function at all <-!tlevels ---------> E^ of orgaiilzation ran(ling fromii the wlhole animllal to in _ ----------\ - ........ceIIll lar, suib cellular, anid mnolectlar levels contribute to *the beadth of its scope. New of these functions ^; descriptions i$4f j^;2 <Ee> ......... tand ofthlellr coiltrol system-is, as 11~~~el as thieir bases in biochemi ~istry, biophysics, genetics, anid cell biology, are presented. Comipleted research de tailinig critical niew linsig,hts *M in to the miechaniismis t ha t determiniie the performianice of the normal anld abniormial ~~~~~~~~~~~heart anid circulationi rounid 5: out thle conitenits. Please enter my subscription to: American Journal of Physiology: Heart and Circulatory Physiology Your subscription will start with the January 1992 issue and you will receive 12 issues in 1992. Non-Member Individual: n $220.00 (USA) g $260.00 (Canada & Mexico) n $290.00 (Elsewhere, includes expedited mailing). APS Member: [ $110.00. Institutional prices on request. Canadian residents add 7% G.S.T. All Maryland residents add 5% sales tax, or provide tax exempt ID#: subscriptions must be paid in advance in U.S. dollars. Foreign payments must be made in U.S. dollars, drawn on a U.S. bank located within the continental United States or charged to MasterCard or VISA. MasterCard Charge my order to: F] VISA Payment enclosed. Card Number _ Signature Expires Date Ship to: Name Address City/State/Province __ Country Zip or Postal Code H Send me information about membership in the American Physiological Society. Send your order or manuscript to: The American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA Association Information you need from the authonty you trust The American Heart Association's newest journal, Heart Disease and Stroke, has been created to address the needs of primary care physicians and practitioners who deal with cardiovascular, cerebrovascular, and peripheral vascular disorders. For the latest in practical, day-to-day information on patient care, refer to Heart Disease and Stroke's featured areas: * Initial examination M* Diagnostic procedures * Medical treatment * Surgical treatment AmericainHeart Association V U Prevention U Reviews U Editorial U Letters to the Editor Finally, a heart journal designed specifically with you in mind. J. Willis Hurst, MD, editor The American Heart Association is particularly pleased to have J. Willis Hurst, MD, as editor of I/Heart Disease and Stroke. Dr. Hurst's distinguished career includes positions at Massachusetts General Hospital, the Bethesda Naval Hospital, and Emory University School of Medicine, Hospital and Clinic, where he is now with the Department of Medicine (Cardiology). He may be better known as editor-in-chief of the classic volume The Heart and as cardiologist to Lyndon B. Johnson, 36th president of the United States. Watch out for us - we're looking out for you. Contact the American Heart Association, Scientific Publishing, 7272 Greenville Ave., Dallas, TX 75231-4596 Phone (214) 706-1400 Fax (214) 691-6342 Circulation Research An Official Journal of the American Heart Association Circulation Research provides a medium for bringing together basic research on the cardiovascular system from various disciplines including biology, biochemistry, biophysics, cellular biology, molecular biology, morphology, pathology, physiology, and pharmacology. The journal also will accept for publication manuscripts on clinical research that contribute to an understanding of fundamental problems. Editor Stephen F. Vatner Editorial Board R. Wayne Alexander Piero Anversa Carl S. Apstein Susan M. Barman William H. Barry Eberhard Bassenge Clive M. Baumgarten Bruce Bean Kathleen H. Berecek Oscar H.L. Bing Sanford Bishop Roberto Bolli Michael R. Bristow L. Maximilian Buja Kevin Campbell John Carroll Reginald Chapman Kenneth Chien Associate Editors Peter Libby Bernardo Nadal-Ginard Harold C. Strauss Managing Editor Stacia Webb Editorial Office Harvard Medical School New England Regional Primate Research Center One Pine Hill Drive, P.O. Box 266 Southborough, MA 01772-9102 Telephone: (508) 624-0014 Fax: (508) 624-0960 Assistant Managing Editors Tony Alves, Yujing Xian David Clapham William Clusin Richard A. Cohen Fitz-Roy E. Curry Peter F. Davies Sue P. Duckles Brenda R. Eisenberg Masao Endoh Gregory Fink William Gaasch Seymour Glagov Robert M. Graham Augustus Grant David R. Harder David R. Hathaway David J. Hearse Thomas Hintze Louis J. Ignarro Jose Jalife Joseph Janicki Craig January Larry R. Jones Robert S. Kass Robert A. Kloner Jonathan W. Lederer Leslie Leinwand Benedict R. Lucchesi Eduardo Marban Gerhard Meissner Eugene R. Morkin Paul Murray Wilmer W. Nichols Ares Pasipoularides Sol Rajfer Paul T. Schumacker Ketty Schwartz Peter J. Schwartz Stephen M. Schwartz Subha Sen Shey-Shing Sheu Paul Simpson Thomas W. Smith Paul D. Stein Gary L. Stiles Hiroyuki Suga Judith Swain Robert J. Tomanek Myron L. Weisfeldt James T. Willerson Frank Yin Consulting Editors Francois M. Abboud, Robert M. Berne, Harry A. Fozzard, Brian F. Hoffman, Matthew N. Levy, Howard E. Morgan, John T. Shepherd Scientific Publishing Committee American Heart Association Chairman Alfred P. Fishman Philadelphia, Pennsylvania Kathleen Case Philadelphia, Pennsylvania Dennis L. DeSilvey Rutland, Vermont Margaret Foti Philadelphia, Pennsylvania Vice Chairman Howard E. Morgan Danville, Pennsylvania Valentin Fuster Boston, Massachusetts Mary Jane Jesse Cincinnati, Ohio Clyde E. Johnson Baton Rouge, Louisiana Kern Wildenthal Dallas, Texas Frank M. Yatsu Houston, Texas An Official Journal of the American Heart Association Circulaion Research (ISSN 0009-7330) is published monthly by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231-4596. Editorial Correspondence should be addressed to Stephen F. Vatner, MD, Circulation Research Editor, Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, PO Box 266, Southborough, MA 01772-9102. Telephone (508) 624-0014. Fax (508) 624-0960. Instructions to Authors appear twice a year, in the January and July issues. Authors should consult these instructions before submitting manuscripts to Circulation Research. Author Costs include page charges, cost of color figures, and cost of offprints, if ordered. Business Correspondence should be addressed to Scientific Publishing, American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231-4596. Telephone (214) 706-1310. Fax (214) 691-6342. Change of Address: Please supply old and new addresses. Allow 6 weeks for changes. Subscription Rates: In the United States, individuals may subscribe to Circulation Research for their personal use at the annual rates of $122 for members of an American Heart Association scientific council and $152 for nonmembers. Outside the United States, add $60 for postage. Medical professionals and scientists in training may subscribe for $76 in the United States and $106 outside the United States if payment is accompanied by a letter from the department chairman verifying post held and completion date. Prepayment is required. Make check, draft, or money order payable to the American Heart Association in US dollars drawn on a US bank, with Circulation Research on the face of the check. To charge on Visa or MasterCard, include account number, expiration date, and name as it appears on card. Contact AHA for single copy rates and subscription rates for libraries, reading rooms, and other multiple-use institutions. Subscription Rates in Japan: Contact Nankodo Co., Ltd., 42-6 Hongo 3-chome, Bunkyo-ku, Tokyo 113, Japan. Telephone 03 (3811) 9950. Fax 03 (3811) 5031. Offprints: For orders of fewer than 100, offprints are available from corresponding authors. For orders of 100 or more, contact Scientific Publishing, Reprint Specialist, Telephone (214) 706-1466. Advertising Correspondence should be addressed to Pharmaceutical Media, Inc., 14th Floor, 440 Park Avenue South, New York, NY 10016. Telephone (212) 685-5010. Fax (212) 685-6126. Advertising copy must be approved by the American Heart Association. Advertising forms close 45 days before the first day of publication month. Secondary Services Indexed or Abstracted in Biological Abstracts, Chemical Abstracts, Energy Research Abstracts, Excerpta Medica, Index Medicus, International Aerospace Abstracts, Life Sciences Collection, PESTDOC, RINGDOC, and VETDOC. Available On-line from BRS Colleague, 8000 Westpark Drive, McLean, VA 22102. Telephone (800) 955-0906. Microform Edition available from University Microfilms International, 300 North Zeeb Road, Ann Arbor, MI 48106-1346. Telephone (313) 761-4700. Authorization to photocopy items from this publication for personal and internal use, or for the personal or internal use of specific clients, is granted by the American Heart Association on the condition that the copier pay a fee of $1.00 per article plus $.10 per page to the Copyright Clearance Center, Inc. (CCC), 27 Congress St, Salem, MA 01970. Telephone (508) 744-3350. Payment should include the fee code 0009-7330/92/$1.00+.10. This consent does not extend to copying for advertising or promotional purposes, for creating new collective works, or for resale. Individuals may make single photocopies for personal, non-commercial use without obtaining permission. For all other use, permission should be sought directly from the American Heart Association. Telephone (214) 706-1309. Copyright 1992 American Heart Association BUGHER FOUNDATION/AMERICAN HEART ASSOCIATION FELLOWSHIP IN MOLECULAR BIOLOGY OF THE CARDIOVASCULAR SYSTEM BRIGHAM & WOMEN'S HOSPITALHARVARD MEDICAL SCHOOL ill *- These fellowships are designed to support individuals with an MD or MD/PhD degree who will pursue postdoctoral training in the molecular biology of the cardiovascular system in a Brigham and Women's Hospital or Harvard Medical School affiliated laboratory. Stipend: $42,000 annually. Candidates must be citizens or permanent residents of the US. Applications from women and underrepresented minorities are strongly encouraged. For further information, contact: Bugher Executive Committee, c/o Ms. Paula McColgan, Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115 Telephone (617) 732-5867 0 Information may be obtained through: *E . American Heart Association Scientific Conference on Cardiovascular Response to Exercise Scientific and Corporate Meetings 7272 Greenville Avenue Dallas, TX 75231-4596 (214) 706-1511 0 O . m 1992 New Orleans, Louisiana November 16-19 1993 Atlanta, Georgia November 8-11 1994 Dallas, Texas November 14-17 American Heart Association 1995 A Anaheim, California November 13-16 3027 ] - : : : :@.32~ ~ ~ ~ ~T-lo;ge -- I- - --- -.. 5 1 CARDIAC OUTPUT COMPUTER B I+ M -P Ceox/IB-5 C Cardiac Output 4,88 L/min 57.6 mL/beat Stroke Ualn _ 84 beats/min Heartratue_ Blood Tieperature_ 36.8 degC MnJectan eTempera7nr-S21 SMstolic Pressure 124 mmHg FOR MAN HUS AND RATS RATS HUMANS FOR 'CARDIOMAX' plus IBM-PC Computer measures, prints on printer and stores on the disc for future recall: *Cardiac Output *Stroke Volume *Heart Rate *Systolic, Diastolic, Mean Blood Pressures *Blood and Injectate Temperatures *Graphic pictures of Dilution Curve, *Blood Pressure and ECG waveforms *Calculates and prints Dilution Curve's Appearance, Elevation, Mean Concentration and Mean Dilution Times. .. _uyust 27, 1985 2:19p^ BP Sagle Ra e 150/Sec F7t F14 GaienC Diastolic PressureC 82 ecHg 1ain F9t F9l4 FI-Standbh F2-C.O. F3-EiF F4-HELP JIrigger Delay: BeSec F5t F64 Nolding ECG . . . ..=. Hl ldel P-Print W.~ ~ ~ ~ ~ ~ ~ 9.97 S-Sane TAil H-Qui t ~ ~ ~~~~2 Icon J~~~~~~~~~~~~~~~~~~~~~~~~~~~. *Helps to calculate EJECTION FRACTION* Also can function as an automatic vital parameters data logger *Can be equipped with an automatic thermodilution injector *Cardiac Output =measuring range from milliliters to hundreds of liters *Can be used in human as well as in animal research applications. Supplied with all -- !necessary software. ^ S|-" COLUMBUS INSTRUMENTS .......... .....................................z P.O. BOX 44049 COLUMBUS, OHIO 43204-0049, USA PHONE (614) 488-6176 TELEX 246514 I ANIMAL EXERCISER & V2Ico2/02 ~METABOLIC COMPUTERl | - i t:fit - Pirogrammer -,-,- * Multi-lane animal exerciser for rats and * mice. * Separate airtight chambers and exercise belts for each animal. Very quiet operation * "Oxymax' multi-channel metabolic computers for 1,2,4,8 andl6 animals. Can operate in conjunction with exercisers. * Systems for very small and large a- M. cnnnA a4t Ad;j .uctahl Llt, flSJU3LaUlct npCCUACt.t. * * Superior accuracy and ease of Programmed exercise schedule with automatic measurements of animal operation. behavior. Please contact us for more information: "";.h linexr;e alluiaul avaulauln. CCOLUMBUS INSTRUMENTS P.O. BOX 44049 COLUMBUS, OH 43204 PH: (614) 488-6176 TOLL FREE:1-800-669-5011 FAX: (614)276-0529 TLX:246514 j