programme - lodz platelet conference

LODZ PLATELET CONFERENCE
jointly with
11th
Erfurt Conference on Platelets
June 25th – 28th, 2006
Lodz, Poland
Organized on behalf of the
European Platelet Group (EPG)
Technical University of Lodz (TUL)
University of Lodz (UL)
Medical University of Lodz (UMED)
Commission of Haemostasis and Thrombosis, the Committee
of Pathophysiology, Polish Academy of Sciences
www.p.lodz.pl/plateletconference
Scientific Committee
Prof. Włodzimierz Buczko - Medical University of Bialystok
Prof. Czesław Cierniewski - Medical University of Lodz
Prof. Ryszard Gryglewski - Jagiellonian University Medical College
Prof. Stan Heptinstall - Medicine University Hospital Nottingham
Prof. Michał Myśliwiec - Medical University of Bialystok
Prof. Peter Spangenberg - University of Applied Sciences, Jena
Prof. Andrzej Szczeklik - Jagiellonian University Medical College
Prof. Krzysztof Warzocha - Institute of Hematology and Transfusiology, Warsaw
Prof. Marek Wojtukiewicz - Medical University of Bialystok
Organizing Committee
Bogdan Walkowiak - Chairman
Wolfgang Loesche
Urszula Kralisz
Zofia Pawłowska
Barbara Wachowicz
Cezary Watała
Witold Szymański - chief of the secretariat
Marta Kamińska - secretary
Dorota Ciepielewska - secretary
Witold Jakubowski - www page
Piotr Niedzielski - treasurer
Bogdan Kontek
Jan Szemraj
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The organizers thank the following who are among those
sponsoring the Conference:
Dade Behring Diagnostics Sp zoo (Poland)
Dade Behring Marburg (Germany)
Wyeth Pharma Münster (Germany)
Branch of Warsaw
SanLab S.C.
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PROGRAMME
Sunday, June 25th, 2006
9:00 – 17:00
Registration
level 0
18:00 – 18:10
18:10 – 18:55
Welcome Message
Opening lecture
Gustav Born (U.K.)
Current questions from earlier answers
level –1
19:00 – 20:30
Welcome Reception
level –1
Monday, June 26th, 2006
Session I
9:00 – 9:55
Chairmen: Giovanni De Gaetano and Cezary Watala
Invited lecture I
Jan W Akkerman (The Netherlands)
Insulin signalling in Diabetes mellitus type 2 platelets
9:55 – 10:25
Oral presentations 1-2
1. R.A.Claus, C.L.Bockmeyer, U.Budde, R.Schneppenheim,
K.Kentouche, M.Bauer, K.Reinhart, F.M.Brunkhorst, W.Lösche
Decrease of ADAMTS13 activity is a common feature of the
inflammatory response (15 minutes)
2. A.Michno, A.Szutowicz
The modification of blood platelet activity by acetyl-CoA and
ATP/ADP in diabetic platelets (15 minutes)
10:25 – 10:50
Coffee break
Session II
10:50 – 11:50
Chairmen: Maria Zellner and Peter Spangenberg
Oral presentations 3-7
level –1
4. P.Järemo, C.Starkhammar, M.Milovanovic, Å.Lundström,
T.L.Lindahl, N.Ravald, A.Richter
Inverse associations between platelet reactivity and the severity of
gingivitis in stable angina pectoris (15 minutes)
5. S.Jones, G.Graham, T.Sage, J.Gibbins
Peripheral tachykinins stimulate activatory signaling pathways in
platelets (15 minutes)
6. P.Bugert, A.Schedel, P.Schloss, H.Klüter
The dopaminergic system of human platelets (15 minutes)
7. P.Manolopoulos, S.Heptinstall, J.R.Glenn, S.C.Fox, J.A.May,
N.Dovlatova, S-W.Tang, N.Bauer, M.Hesse, N.R.Thomas,
V.Ralevic
Acyl derivatives of coenzyme a inhibit ADP-induced platelet
function via antagonism at P2Y1 and P2Y12 receptors (15
minutes)
11:50 – 14:00
Lunch
4
level –1
Session III
14:00 – 14:55
Chairmen: Jan W. Akkerman and Czeslaw S. Cierniewski
Invited lecture II
level –1
Czeslaw S. Cierniewski (Poland)
Platelet microparticles and angiogenesis
14:55 – 15:50
Invited lecture III
level –1
Elizabeth Kornecki (USA)
Role for the F11 Receptor (F11R; JAM-A) in hemostasis,
inflammatory thrombosis and atherosclerosis
15:50 – 16:15
Coffee break
Session IV
16:15 – 17:00
Chairmen: Patricia Maguire and Wolfgang Lösche
Oral presentations 8-10
level –1
8. R.A.Claus, C.L.Bockmeyer, S.Reiss, R.Schneppenheim,
W.Lösche, V.Oberle
Direct interaction of platelet derived microvesicels with Von
Willebrand factor: a microscopic study (15 minutes)
9. R.Polanowska-Grabowska, R.A.Figler, M.A.Marshall, K.Wallace,
A.R.L.Gear, J.Linden
Blood platelet activation in a transgenic mouse model of sickle cell
disease (15 minutes)
10. M.Boncler, M.Nocuń, P.Gresner, R.Wilk, J.Rysz, C.Watala
Acetylation of platelet proteins by acetylsalicylic acid is decreased
in hypercholesterolemic patients (15 minutes)
18:30 -
Conference dinner
- the Biederman Palace
Tuesday, June 27th, 2006
Session V
9:00 - 9:55
Chairmen: Elizabeth Kornecki and Włodzimierz Buczko
Invited lecture IV
level –1
Giovanni de Gaetano (Italy)
Should we forget about platelets and move to leucocytes?
9:55 – 10:50
Invited lecture V
Stan Heptinstall (U.K.)
Leukocytes influence platelet aggregation more than you think
10:50 – 11:15
Coffee break
Session VI
11:15 – 13:00
Chairmen: Barbara Wachowicz and Peter Presek
Oral presentations 11-17
level –1
11. V.Oberle, R.Rüger, A. Fahr, W.Lösche
Negatively charged liposomes used for drug delivery bind to
platelets and leukocytes and activate them (15 minutes)
12. S.C.Fox, J.A.May, S.Heptinstall
Quantitation of endothelial microparticles in plasma samples is
impaired by chylomicrons following ingestion of a fatty meal
(15 minutes)
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13. M.Milovanovic, L.Kourosh, T.L.Lindahl, C.Hallert, P.Järemo
Platelet density variations in essential thrombocytemia (15
minutes)
14. C.Watala, R.Golanski, W.Kuliczkowski, P.Gresner, J.Golanski
More on aspirin resistance: position paper of the working group on
aspirin resistance. The next opening. Our proposal for a laboratory
test of “aspirin resistance” (15 minutes)
15. W.Kuliczkowski, J.Golanski, R.Golanski, S.Chlopicki,
J.Baraniak, C.Watala
Acetylsalicylic acid non-responsiveness after coronary artery
bypass grafting surgery results in higher TXB2 generation under
shear stressconditions (15 minutes)
16. A.Schaarschmidt, J.Konter, S.Reiss, V.Oberle, R.A.Claus,
E.Glusa, J.Lehmann, W.Lösche
Inhibition of platelet aggregation by 4-methyl piperidine NONOate
is mediated by plasma factors but not by cGMP (15 minutes)
17. A.Juška, I.Jardin, G.M.Salido, J.A.Rosado
Functional characteristics of two types of calcium stores and
SERCAs in human platelets (15 minutes)
13:00 – 15:00
Lunch
Session VII
15:00 – 17:00
Chairmen: Janusz Szemraj and Marek Wojtukiewicz
Poster session
level -1
p 01. J.Saluk-Juszczak, B.Olas, P.Nowak, B.Wachowicz
Antioxidative effects of D-glucaro 1,4-lactone against peroxynitrite induced modifications in blood platelet
p 02. B.Olas, J.Saluk-Juszczak, I.Pawlaczyk, P.Nowak,
J.Kołodziejczyk, R.Gancarz, B.Wachowicz
Response of blood platelets to an extract from Conyza canadensis
in vitro
p 03. T.Domaniewski, A.Karp, A.Mogielnicki, E.Chabielska,
W.Buczko
The effect of ACE-Is on platelet adhesion and aggregation in rats
p 04. C.L.Bockmeyer, W.Lösche, V.Oberle, A.Helbig,
N.Kretschmar, T.Hilberg, R.A.Claus
Physical stress as a model to study variations in ADAMTS13
activity; Von Willebrand factor and platelet activation
p 05. K.Bednarska, A.Olejniczak, B.A.Wojtczak, Z.Sułowska,
Z.Leśnikowski
Adenosine modified with boron cluster pharmacophore as new
potent platelet inhibitors
p 06. K.Bednarska, A.Schromm, T.Cieślikowski, A.St.Świerzko,
W.Kaca, Z.Sułowska
Evidence for direct regulatory interactions between
lipopolysaccharide, thrombin and platelets: differential effects of
LPS from Escherichia coli and Proteus mirabilis on thrombin
activity and platelet activation
p 07. K.Fälker, D.Lange, P. Presek
Signaling pathways mediated by the P2Y12 ADP receptor upon
thrombin stimulation in human platelets
p 08. A.Dietrich-Muszalska, B.Kontek
Generation of superoxide anion in blood platelets of patients with
schizophrenia of paranoid type
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p 09. A.White, J.Glenn, S.Fox, A.Johnson, B.Myers, S.Heptinstall
Reduced platelet aggregation to ADP and ATP in patients with
leucocytosis is due to enhanced rates of adenine nucleotide
metabolism mediated by the NTPDase CD39
p 10. K.Oszajca, B.Walkowiak, E.Chabielska, J.Bartkowiak,
J.Szemraj
A new thrombolytic, antiplatelet agent with higher fibrin affinity
– a staphylokinase variant
p 11. V.Bichan, A.Samal, Z.Zabarovskaya
Ca+ signalling in pregnant women with gestational diabetes mellitus
p 12. E.Nita, L.Konopka, K.Bykowska, K.Maślanka, S.Łopaciuk,
Z.Traczyk, R.Woroniecka, B.Pieńkowska-Grela
Bernard-Solulier syndrome in three siblings with a
supernummerary small marker chromosome
p 13. M.L.Udvardy, J.Kappelmayer, J.Hársfalvi
Glycocalicin coated beada for studyind platelet GPIB function
p 14. B.Nagy Jr, É.Csongrádi, I.Balogh, M.Káplár, G.Paragh,
J.Kappelmayer
Evaluation of increased Platelet activation and the effect of
P-selectin gene (T715P) polymorphism in type 2 diabetes mellitus
and obesity
p 15. M.Rozalski, B.Luzak, J.Rywaniak, S.Rozalska, T.Poplawski,
R.Sychowski, C.Watala
Genotyping the common polymorphisms of platelet
purinoreceptors. Methodological aspects
p 16. M.Zellner, M.Diestinger, E.Rappold, W.Winkler, F.Garo,
R.Oehler
Platelet proteome profiling from dementia patients
p 17. B.Walkowiak, M.Kamińska, W.Okrój, W.Tanski, A.Sobol,
Z.Zbróg, I.Przybyszewska-Doroś
Blood platelet proteome is changed in uremic patients
p 18. L.Michalec, K.Błędzka, J.Szymański, C.S.Cierniewski
The specificity and function of the reconstituted αIIbβ3 and αvβ3
minireceptors
p 19. W.Okrój, B.Pietrzyk, L.Klimek, W.Jakubowski, W.Szymański,
M.Kamińska, Przybyszewska-Doroś, P.Komorowski, B.Walkowiak
Thrombocompatibility of titanium oxide deposited on stainless steel
by sol-gel method
p 20. I.Przybyszewska-Doroś, M.Kamińska, W.Okrój,
W.Jakubowski, W.Szymański, P.Komorowski, B.Walkowiak
Blood platelets activation by artificial surfaces
19:00 –
Pub tour
- pubs on Piotrkowska Street
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Wednesday, June 28th, 2006
Session VIII
9:00 – 9:55
Chairmen: Zofia Pawlowska and Stan Heptinstall
Invited lecture VI
level –1
Patricia B Maguire (Ireland)
Using platelet proteomics to identify potential therapeutictargets
9:55 – 10:40
Invited lecture VII
Maria Zellner (Austria)
Biological variations and age-related changes in the platelet
proteome
10:40 – 11:00
Coffee break
Session IX
11:00 – 12:15
Chairmen: Urszula Kralisz and Gianpiero Pescarmona
Oral presentations 18-22
level –1
18. GP.Pescarmona, E.De Vivo
Platelets as a diagnostic tool for evaluation of hormonal status in
ageing (15 minutes)
19. M.Reinhöfer, C.Macholdt, U.Franke, D.Barz, G.Marx,
K.Reinhart, W.Lösche
Monitoring peri-operative haemostasis by ROTEM
thromboelastometry in patients with cardiac surgery (15 minutes)
20. J.Baranyai, J.Winning, R.A.Claus, I.Eisenhut, J.Hamacher,
K.Reinhart, M.Bauer, W.Lösche
Inhibition of platelet function by aspirin or clopidogrel reduces
organ injury in sepsis: first clinical and experimental data
(15 minutes)
21. T.S.Charnavets, V.M.Mazhul
The role of platelets phospholipids metabolism products in the
mechanisms of protease-induced platelet aggregation (15 minutes)
22. W.Kuliczkowski, I.Pawlaczyk, M.Czuba, B.Karolko, R.Gancarz
The in vitro antiplatelet effect of the extract from Conyza
canadensis - preliminary report (15 minutes)
12:15 – 12:30
Closing remarks
12:30 – 14:00
Lunch
level –1
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Sunday, June 25th, 2006
9:00 – 17:00
Registration
level 0
18:00 – 18:10
18:10 – 18:55
Welcome Message
Opening lecture
Gustav Born (U.K.)
Current questions from earlier answers
level –1
level –1
19:00 – 20:30
Welcome Reception
level –1
9