BIDMC Obstetrics and Gynecology 2013 Annual Report
Transcription
BIDMC Obstetrics and Gynecology 2013 Annual Report
BIDMC Obstetrics and Gynecolog y 2013 Annual Report Table of Contents 4 Chair’s Message 48 Female Pelvic Medicine and 6 Who We Are 8 A Medical History of BIDMC 51 Urogynecology at 52 Neonatology 13 Clinical 14 Obstetrics and Gynecology 25 Maternal-Fetal Medicine/High-Risk Obstetrics and Clinical Genetics 31 Gynecologic Oncology 35 Colposcopy and Laser Surgery Unit 36 Family Planning 38 Reproductive Endocrinology and Infertility 43 Minimally Invasive Gynecologic Surgery Mount Auburn Hospital 57 Quality, Safety, and Performance Improvement 65 Nursing 68 Social Work 70 Education 71 Maternal-Fetal Medicine Fellowship 72 Reproductive Endocrinology and Infertility Fellowship BIDMC OB/GYN Annual Report 2013 11 Honors and Awards Reconstructive Surgery 2. Previous Section • Next Section Table of Contents 73 Female Pelvic Medicine and 95 Social Mission 96 Community Health Consortium 74 Obstetrics and Gynecology Residency Program 77 Administrative Chief Resident 79 Medical Student Education 97 Global and Community Health Program 100The Parent Connection 101 Service-Based Learning and BIDMC OB/GYN Annual Report 2013 Reconstructive Surgery Fellowship Research Projects 82 Research 104Living in Boston 83 Research 106Publications 87 Preeclampsia and Hypertensive Disorders of Pregnancy 88 Reproductive Endocrinology Research 90 Optical Diagnosis of Disease 93 Medical Education Research 3. Previous Section • Next Section BIDMC OB/GYN • Chair ’s Message Chair’s Message Beth Israel Deaconess Medical Center (BIDMC), a major teaching hospital of Harvard Medical School, is known for its quality research, and outstanding educational programs. Our distinctive blend of academic rigor, combined with empathic family-centered care, makes us unique. As a flagship teaching hospital of Harvard Medical School, the faculty in the Department of Obstetrics and Gynecology at BIDMC teaches obstetrics and gynecology to a third of all Harvard Medical students. The department offers a residency program in obstetrics and gynecology to 20 residents, with 5 residents per year. Our intimate program gives residents a feeling of individuality that is partnered with an emphasis on evidence-based medicine and research. We offer felHope Ricciotti, MD Acting Chair of Obstetrics and Gynecology –> Table of Contents lowship programs in Maternal–Fetal Medicine and in Reproductive Endocrinology and Infertility. An accredited fellowship in Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 and value in patient care, leading-edge clinical and basic science 4. BIDMC OB/GYN • Chair ’s Message Female Pelvic Medicine and Reconstructive Surgery is offered is a leader in educational research in women’s health. We believe in partnership with the Mount Auburn Hospital in Cambridge, that it takes a team effort to deliver quality health care. Our ex- Massachusetts. An Ob/Gyn Clinical Informatics Fellowship is traordinary group of attending physicians, fellows, residents, and offered in collaboration with the BIDMC Division of Informat- medical students work in partnership with our world-renowned ics. Through close collaborations with other departments at the nurses and staff to care for patients. A tradition of service to com- medical center and at Harvard Medical School, the department munity is at the core of our founding hospitals and remains an im- has a varied research portfolio. Our programs reflect the diversity portant part of our mission. Our diverse patient population hails that is valued in our department, and include clinical, basic sci- from various racial, ethnic, and socioeconomic backgrounds, and ence, public health, health care quality, and educational projects. we are committed to eliminating health disparities. We take great Our collaborations on the pathogenesis of preeclampsia have pride in providing innovative care with a personal touch. led to exciting basic research findings and potential new clinical therapies. The department also places special emphasis on Hope Ricciotti, MD epidemiology and public health policy as it relates to women’s Acting Chair of Obstetrics and Gynecology health both in the United States and globally. The department is a leader in the effort to improve patient safety and in outcomesbased research. Our simulation and team training curricula, which include teambased training exercises, are nationally renowned. Finally, in concert with Harvard Medical School, the department BIDMC OB/GYN Annual Report 2013 Chair’s Message continued 5. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Who We Are Who We Are Beth Israel Deaconess Medical Center rael Deaconess Medical Center is an affiliate of Harvard Medical School, offering patient care as well as teaching and research programs. Three-quarters of a million patients are served each year, with 649 licensed beds, including 440 for medical/surgical patients, 77 for critical care, and 60 for Ob/Gyn. Our Level III Neonatal Care Unit has 47 licensed beds. BIDMC consistently ranks among the top three recipients of biomedical research funding from the National Institutes of Health. Research funding totals $229.8 million annually, and BIDMC researchers run more than 850 active, sponsored projects and 500 funded and nonfunded clinical trials. BIDMC OB/GYN Annual Report 2013 Located in the heart of Boston’s medical community, Beth Is- 6. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Who We Are Who We Are continued Department of Obstetrics and Gynecology Preventative women’s health care and complex, state-of-the-art services to the most critical of patients are all within the realm of the women receive our unique brand of patient- and family-centered care. While we are proud to be one of the most sought-after teaching hospitals in the country, we focus our attention on each and every one of the nearly 5,000 babies we deliver each year. Harvard Medical School Harvard Medical School opened its doors in 1782 to a handful of students and just three faculty members. Today, with over 11,000 faculty on board, more than 5,000 students apply for the 165 openings at the school each year. Under the leadership of Dean Dr. Jeffrey Flier, the Caroline Shields Walker Professor of Medicine at Harvard Medical School and former Chief Academic Officer for BIDMC, Harvard Medical School lives out its mission “to create and nurture a community of the best people committed to leadership in alleviating human suffering caused by disease.” The school attracts some of the best and brightest students from around the country, and every class exhibits its own brand of creativity and interests, making its members the medical leaders of tomorrow. BIDMC OB/GYN Annual Report 2013 compassionate, highly personalized treatment provided in BIDMC’s Department of Obstetrics and Gynecology. A diverse community of 7. –> Table of Contents Previous Section • Next Section A Medical Histor y of BIDMC BIDMC OB/GYN • Medical Histor y 196 0 19 70 1986 BIH delivers first baby conceived through in vitro fertilization in Massachusetts. 198 0 19 90 1995 Deaconess Hospital performs New England’s first minimally invasive coronary bypass surgery and implants first deep brain stimulator for treatment of Parkinson’s. 1998 BIDMC performs first adult live donor liver transplant in New England. –> Table of Contents 19 95 1991 BIH researchers first to discover evidence that abnormalities in visual system of brain help explain dyslexia symptoms. 1983 Deaconess Hospital performs first successful liver transplant in New England. 1998 BIDMC cardiothoracic surgeon William Cohn issued patent for Cohn Cardiac Stabilizer, allowing coronary artery bypass surgery without a heart-lung machine. BIDMC OB/GYN Annual Report 2013 1972 BIH implements nation’s first Rights of Patients statement. 1960 Beth Israel Hospital (BIH) develops first implantable cardiac pacemaker. 8. 20 0 0 Previous Section • Next Section A Medical Histor y of BIDMC BIDMC OB/GYN • Medical Histor y 2003 BIDMC researchers discover probable cause of preeclampsia and publish results in New England Journal of Medicine and Journal of Clinical Investigation. 20 02 20 03 20 0 4 20 0 5 2007 BIDMC’s Department of Ob/Gyn receives Joint Commission award for excellence in patient safety and innovation. –> Table of Contents 2006 US News & World Report places BIDMC among nation’s Best Hospitals in 6 clinical specialties. 20 0 6 20 0 7 2008 BIDMC reports in Nature that COMT gene, known for its role in schizophrenia, also plays a role in preeclampsia. 20 0 8 20 0 9 2005 BIDMC reports the involvement of s-Flt1 factor in preeclampsia in New England Journal of Medicine. 2006 BIDMC reports a team training method for patient safety in obstetrics in JAMA. 2007 BIDMC’s Department of Ob/Gyn first recipient of BCBS of Massachusetts Health Care Excellence Award in patient safety programs. 2009 BIDMC among 3 hospitals recognized for leadership/ innovation in quality, safety, and commitment to patient care as American Hospital Association–McKesson Quest for Quality Prize® finalist. 2009 US News & World Report ranks BIDMC in Top 50 for care and treatment of heart and heart surgery; cancer; digestive disorders; kidney diseases; geriatrics; gynecology; ears, nose, and throat; diabetes (in conjunction with Joslin Clinic). Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 20 0 1 9. A Medical Histor y of BIDMC BIDMC OB/GYN • Medical Histor y 20 10 2011 US News & World Report names BIDMC Top Hospital, plus Honorable Mention for the Gynecology Division. 2011 BIDMC first nationally to meet federal electronic health record requirements with its own software technology supporting ARRA’s quality, safety, and efficiency goals. 20 1 1 2012 US News & World Report ranks BIDMC among top 3% of all hospitals nationally. 20 12 2013 US News & World Report again ranks BIDMC as in the top 3% of hospitals nationally. 2012 Becker’s Hospital Review places BIDMC on its list of year’s 100 Great Hospitals. 2012 International Board of Lactation Consultant Examiners and International Lactation Consultant Association recognize BIDMC for excellence in lactation care. 10. 20 13 –> Table of Contents BIDMC OB/GYN Annual Report 2013 2011 BIDMC named nation’s top-ranked healthcare information company and 12th overall on InformationWeek 500, a list of top US technology innovators. 2010 BIDMC awarded $38.2 million from NIH as part of American Recovery and Reinvestment Act (ARRA). BIDMC scientists receive 69 grants across all departments. Previous Section • Next Section BIDMC OB/GYN • Honors and Awards Honors and Awards The BIDMC family includes a large staff of dedicated employees, working both behind the scenes and upfront with direct patient care. Here’s just a small sampling of special awards and honors •For the 3rd consecutive year, BIDMC distinguished by the •For the 11th time, Truven Health Analytics names BIDMC one Human Rights Campaign’s Healthcare Equality Index as a of the Top 100 US Hospitals—and the only Boston hospital leader in LGBT healthcare equality. The award recognizes cited this year. efforts in delivering equitable care, guaranteeing equal visita- •For the 6th time in 7 years, the national Leapfrog Group ranks tion for same-sex partners/parents, and providing LGBT health BIDMC as a Top Hospital. education for key staff members. •In the Leapfrog Group’s latest update to the Hospital Safety •BIDMC one of 10 medical centers across the country and the Score, BIDMC receives an A rating. only hospital in Massachusetts chosen to pilot a resident •BIDMC one of 11 hospitals nationally included in the chapter of the Gold Humanism Honor Society. Drs. Katherine Hitachi Foundation’s Pioneer Employee Hospitals Initiative Johnson and Zoe McKee represent the Department of Ob/Gyn for its commitment to addressing key personnel shortages by in the inaugural chapter. training existing employees to advance professionally. BIDMC OB/GYN Annual Report 2013 received so far this year: 11. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Honors and Awards Honors and Awards continued •BIDMC honored by the US Environmental Protection Agency with an Environmental Merit Award for making significant contributions toward protecting and preserving the nation’s BIDMC OB/GYN Annual Report 2013 natural resources. •BIDMC honored as Partner for Change, with Distinction at the Practice Greenhealth Environmental Excellence Awards for aggressive goals for recycling, regulating medical waste, and progress in environmentally preferred purchasing. •BIDMC becomes first hospital in the nation to join and be recognized by the EPA’s Food Recovery Challenge. •Dr. Yvonne Gomez-Carrion received Harvard Medical School’s 2013 Dean’s Community Service Faculty Award for her work with Concerned Black Men of Massachusetts, a group that promotes young men’s personal development. 12. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 Clinical 13. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Obstetrics and Gynecology Hope Ricciotti, MD Division Director Sandra Mason, MD Clinical Director Shapiro Practices Renee Goldberg, MD Clinical Director Community Practices Renee Goldberg, MD BIDMC OB/GYN Annual Report 2013 Sandra Mason, MD 14. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Faculty Ambulatory Practices Community Faculty Practices Community Health Centers Shapiro 8 Faculty Practice One Brookline Place Bowdoin Street Health Center (hospital-based practice) Cindy Kobelin, MD Sarah Averbach, MD K. Meredith Atkins, MD Chestnut Hill Celeste Royce, MD Diane Kaufman, MD Dimock Street Health Center Chelsea Anjelica Garza, MD Laura Bookman, MD (Gyn only) Toni Golen, MD Yvonne Gomez-Carrion, MD Ronald Marcus, MD (Gyn only) Monica Mendiola, MD Hope Ricciotti, MD Jennifer Scott, MD, MPH, MBA Sandra Mason, MD Needham Neel Shah, MD, MPP Renee Goldberg, MD Jacqueline Stephen, MD (Gyn only) Susan Lincoln, MD (Gyn only) (Chinatown and Quincy) Isabel Morais, MD Kristin Bixel, MD Lexington Allegra Deucher, MD Marc Kobelin, MD Milton Alice Shin, MD South Cove Community Health Center Ira Chan, MD, MPH Lucy Chie, MD, MPH Janet Chollet, MD Fenway Community Health Center Sandra Mason, MD BIDMC OB/GYN Annual Report 2013 Obstetrics and Gynecology continued 15. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 16. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical BIDMC OB/GYN Annual Report 2013 Obstetrics and Gynecology: Education Patient care is the foundation for resident and medical student training in BIDMC’s Department of Obstetrics and Gynecology. Residents spend all 4 years of their training working with faculty in both ambulatory and in-patient settings. Upon graduation, they are well prepared to work as independent practitioners in general practice. Ambulatory settings include hospital-based practices, suburban settings, and affiliated community health centers, all of which provide diverse patient care experiences, exposure to faculty with a variety of interests and expertise, and a lifetime of options for contributing to the education of patients and service to community. 17. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical different needs at different times Obstetrics and Gynecology: Clinical Care of their lives. The generalists Well-woman care, obstetrical care, and gynecologic and meno- provide gynecologic and prenatal health services offered through the department. Our deep, abid- care throughout all the transitions ethnic, racial, and sexual backgrounds is unyielding. Working in a woman may go through, from a pause management are among the comprehensive women’s ing commitment to provide care for women of all socioeconomic, concert with our maternal-fetal and gynecologic specialists, the obstetrician/gynecologist oversees and coordinates exceptional young adult through menopause care for each patient. Physicians are available at many locations and beyond.” ess Medical Center, Brookline, Chelsea, Chestnut Hill, Lexington, Renee Goldberg, MD in the greater Boston community, including Beth Israel DeaconMilton, and Needham, as well as the community health centers Bowdoin Street Health Center, Dimock Center, South Cove Community Health Center, and Fenway Health. BIDMC OB/GYN Annual Report 2013 “We understand that women have 18. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Nulliparas as a Proportion of Total Deliveries Total Deliveries Nulliparas Nulliparas Percentage Nulliparas Percentage Cases 40% 5000 41% 4823 4670 42% 4763 42% 42% 41% 4601 4571 4507 45% 44% 4000 30% 3864 3000 2000 1986 1848 2018 1879 1913 2010 1594 15% 1000 0% 0 FY2007 FY2008 FY2009 FY2010 FY2011 FY2012 FY2013* *October 2012 to July 2013, 10 Months BIDMC OB/GYN Annual Report 2013 6000 19. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Total Cesareans Total Deliveries Total Cesareans Cesarean Percentage Total Cesareans Percentage Cases 7000 45% 39% 6000 5000 4823 4670 37% 4763 37% 36% 31% 4601 4571 4507 34% 30% 3864 4000 3000 2000 1882 1868 1759 1651 1624 15% 1546 1181 1000 0 0% FY2007 FY2008 FY2009 FY2010 FY2011 FY2012 FY2013* *October 2012 to July 2013, 10 Months BIDMC OB/GYN Annual Report 2013 40% 20. –> Table of Contents Previous Section • Next Section Nulliparous Term Singleton Vertex (NTSV) NTSV Deliveries NTSV Cesareans NTSV Cesarean Percentage NTSV Cesarean Percentage Cases 37% 40% 36% 33% 34% 31% 29% 2000 1986 1958 1824 1889 1853 30% 25% 1913 1601 20% 1000 698 680 651 626 591 10% 559 404 0 0% FY2007 FY2008 FY2009 FY2010 FY2011 FY2012 FY2013* *October 2012 to July 2013, 10 Months BIDMC OB/GYN Annual Report 2013 3000 21. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical VBAC Success Rate All VBACs All VBACs + Failed TOL VBACs Success Rate Linear (All VBACs) VBAC Success Rate Percentage Cases 200 80% 76% 69% 69% 67% 63% 150 60% 100 92 82 78 77 75 40% 86 113 20% 50 71 118 71 112 76 117 78 130 88 134 108 149 80 124 0% 0 FY2007 FY2008 FY2009 FY2010 FY2011 FY2012 FY2013* *October 2012 to July 2013, 10 Months BIDMC OB/GYN Annual Report 2013 69% 64% 22. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical OB Episiotomy Total Vaginal Deliveries Episiotomy Cases Episiotomy Percentage Cases 4823 4670 4763 16% 4601 4571 4507 3864 4000 3000 12% 9% 8% 8% 7% 8% 7% 7% 2000 5% 4% 1000 421 355 364 370 340 323 175 0% 0 FY2007 FY2008 FY2009 FY2010 FY2011 FY2012 FY2013* *October 2012 to July 2013, 10 Months BIDMC OB/GYN Annual Report 2013 5000 Episiotomy 23. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical OB Induction 37—39 Weeks Total Deliveries Induction of Labor Cases Induction of Labor Percentage Induction of Labor Percentage Cases 15% 13% 14% 15% 14% 13% 12% 4000 10% 3000 8% 2825 2684 2660 2669 2515 9% 2597 2000 6% 1736 3% 1000 394 376 374 345 354 219 172 0 FY2007 FY2008 FY2009 FY2010 FY2011 FY2012 0% FY2013* *October 2012 to July 2013, 10 Months BIDMC OB/GYN Annual Report 2013 5000 24. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Maternal-Fetal Medicine/ High-Risk Obstetrics and Clinical Genetics Steven J. Ralston, MD, MPH, Division Director Faculty Achilles Athanassiou, MD BIDMC OB/GYN Annual Report 2013 Karen O’Brien, MD Sarosh Rana, MD Jami Alynn Star, MD Brett C. Young, MD Affiliated Faculty Ananth Karumanchi, MD, PhD, Nephrology Catherine Bearce Nowak, MD, Medical Director Clinical Genetics Clinical Faculty Deborah Platek, MD (Harvard Vanguard) Mary Vadnais, MD, MPH (Harvard Vanguard) Steven J. Ralston, MD, MPH 25. –> Table of Contents Previous Section • Next Section 7,500 Maternal-Fetal Medicine/ High-Risk Obstetrics and Clinical Genetics: Education Fellows, residents, medical students, and attending staff all benefit from the compre- The Division of Maternal-Fetal hensive educational environment found in the Division of Maternal-Fetal Medicine and Medicine provided consulta- Clinical Genetics. Second- and third-year residents team up with the Maternal-Fetal tions to over 7,500 women and Medicine Fellow and High-Risk Obstetrical Chief Resident on all academic and patient families experiencing a high- care matters. Frequent clinical exchanges with anesthesiology, neonatology, genetics, risk pregnancy in the last year. radiology, nephrology, endocrinology, and hematology are all part of the experience. Faculty and fellows staff morning sign-out on Labor and Delivery, and the division sponsors a weekly multidisciplinary Perinatal Conference of faculty to optimally treat women with challenging obstetrical issues. Teaching in the clinical setting is supplemented by bimonthly resident didactic series presentations. BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 26. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Maternal-Fetal Medicine/ High-Risk Obstetrics and Clinical Genetics: Clinical Care Maternal-fetal medicine faculty offer targeted and specialized ultrasound examinations, prenatal diagnosis, and genetic counseling at BIDMC as well as at a variety of healthcare facilities throughout Massachusetts. We foster a close and productive relationship with 177 community-based Ob/Gyns, family practitioners, and midwives, providing outstanding care while enhancing patient convenience and satisfaction. Last year, 177 women were transported by helicopter, plane, or ambulance to BIDMC’s Labor and Delivery unit for acute care. Our maternal transport program supports hospitals Last year, 177 women were transported by helicopter, plane, or throughout New England and has transported patients from as far away as Bermuda. The ambulance to BIDMC’s Labor and majority of cases require Maternal-Fetal Medicine services or Level III neonatal intensive Delivery unit for acute care. care. Faculty also collaborate with programs such as the Advanced Fetal Care Center at Boston Children’s Hospital, an association that allows diverse diagnostic and treatment options, including invasive antenatal and peripartum procedures. These clinical advances help fetuses affected by congenital abnormalities and offer hope and guidance to families. BIDMC OB/GYN Annual Report 2013 Patients from all over New England are referred to BIDMC for high-risk obstetrical care. 27. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical BIDMC OB/GYN Annual Report 2013 Maternal-Fetal Medicine/ High-Risk Obstetrics and Clinical Genetics: Clinical Care The Clinical Genetics faculty works alongside the Maternal-Fetal Medicine faculty to provide counseling and support for women and families at risk for pregnancies complicated by genetic disease, birth defects, or intellectual disability. Counseling is also available for individuals or couples experiencing infertility or recurrent pregnancy loss. Program staff meets with families to discuss individual concerns, provide risk assessments, and aid in decision making regarding additional testing—complex genetic counseling information is summarized in a letter for additional understanding. 28. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical a high level of technical skill and clinical acumen; but we also need a high degree of empathy to compassionately guide pregnant women to healthy outcomes for themselves and their babies.” Steven J. Ralston, MD, MPH BIDMC OB/GYN Annual Report 2013 “Maternal-Fetal Medicine is a subspecialty that demands 29. –> Table of Contents Previous Section • Next Section 28,000 Maternal-Fetal Medicine/ High-Risk Obstetrics and Clinical Genetics: Prenatal Diagnosis The Division of Maternal-Fetal Medicine provides obstetrical ultrasound and consulta- The Division of Maternal-Fetal tive services for pregnancies at risk for fetal abnormalities and adverse pregnancy out- Medicine provided over 16,000 comes. Patients receive state-of-the art diagnostic care with 2D, 3D, and 4D capabilities. ultrasound examinations last year, Diagnostic procedures include chorionic villus sampling and amniocentesis, as well as and examinations a variety of therapeutic procedures such as fetal blood transfusions and shunting. The this year are projected to exceed Center for Maternal-Fetal Medicine at BIDMC also includes an antenatal testing unit for 28,000. all pregnancies. The Division of Maternal-Fetal Medicine provided consultations to over ultrasound 7,500 women and families experiencing a high-risk pregnancy in the last year. We also provided over 16,000 ultrasound examinations last year, and ultrasound examinations this year are projected to exceed 28,000. BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 30. –> Table of Contents Previous Section • Next Section Gynecologic Oncology Christopher Awtrey, MD, Division Director Leslie Garrett, MD Christopher McCann, DO Affiliated Faculty Stephen Cannistra, MD, Director, Gynecologic Medical Oncology Jonathan Hecht, MD, PhD, Christopher Awtrey, MD Pathology, Perinatal, Placental, Gynecology BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 31. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Gynecologic Oncology: Education “Our goal in the Each year, residents rotate in the Division of Gynecologic Oncology, along with third- Division of Gynecologic year medical students and fourth-year subinterns. This unique academic environment includes a weekly Gynecologic Oncology Tumor Board—a multidisciplinary conference attended by division members as well as pathologists, radiologists, medical oncologists, and radiation therapists to discuss each patient’s clinical course and treatment options. A gynecologic oncology journal club and monthly research meetings are also among sponsored activities. Daily rounds, assisting in surgical procedures, and presenting at Tumor Board are among resident responsibilities. Residents experience the full breadth of cancer care and risk reduction by participating in cancer genetic counseling sessions and medical chemotherapy ambulatory management. Clinical education also includes simulated surgical practice and participation in the colposcopy/laser ambulatory clinics, where they are taught the principles of colposcopy and the place of laser surgery in gynecology, and they graduate with certification in laser surgery. Almost every graduating class over the past decade has had one graduate continue training in a Gynecologic Oncology Fellowship—a testament Oncology is to provide compassionate, individualized care of the highest quality, to all patients with a suspected or diagnosed gynecologic cancer.” Christopher Awtrey, MD to the division’s educational program. BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 32. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Gynecologic Oncology: Clinical Care Medical oncologists, radiation oncologists, and pathologists work with the division’s physicians on patient-centered, multidisciplinary teams to provide optimal treatment for women with cancer of the reproductive tract. Therapeutic options include open surgery (encompassing radical and ultra-radical procedures), BIDMC OB/GYN Annual Report 2013 minimally invasive surgery, robotic surgery, radiation, chemotherapy, and biological therapies. Clinical outreach programs are in operation at Mount Auburn Hospital, Lawrence General Hospital, Anna Jacques Hospital, and Brockton Hospital. Clinical trials are open to patient accrual through the Dana-Farber/Harvard Cancer Center. We are also a participating institution of the national Gynecologic Oncology Group clinical trials, whose mission is entwined with our own: to promote excellence in the quality and integrity of clinical and basic scientific research in the field of gynecologic malignancies. We work in close collaboration with Dr. Stephen Cannistra, a nationally recognized medical oncologist with particular expertise in ovarian cancer. 33. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical GYN Cancer Surgical Approach** GYN Cancer Total Open Cases GYN Cancer Total LSC/HSC Cases LSC/HSC Cases Percentage LSC/HSC Cases Percentage Cases 50% 45% 46% 39% 36% 150 100 86 78 50 40% 135 135 127 109 28% 41% 38% 30% 83 20% 35 31 42 48 56 62 10% 23 0% 0 FY2007 FY2008 FY2009 FY2010 FY2011 FY2012 FY2013* *October 2012 to July 2013, 10 Months **BIDMC Cases Only, Coded as Malignancy –> Table of Contents LSC/HSC - Laparoscopy and Hysteroscopy Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 200 34. BIDMC OB/GYN • Clinical Elizabeth Buechler, MD, Director The Colposcopy Clinic is a referral-based clinic for patients with benign and pre-invasive disease involving the vulva, vagina, and cervix. Most patients are referred for the evaluation of abnormal Pap tests, persistent high-risk HPV tests, and DES exposure. Women with abnormal Pap tests during pregnancy are followed for evidence of developing invasive disease. Patients who have condyloma or other vulvar lesions, and have not responded to the usual modes of therapy, are also referred for evaluation and treatment. When indicated, treatment with LEEP (loop electrosurgical excision procedure) or lAser is performed either in the Gyn Minors Clinic or operating room. Second-year residents initiate their training in colposcopy in this unit, and by graduation will have the skills and opportunity to obtain laser certification. BIDMC OB/GYN Annual Report 2013 Colposcopy and Laser Surgery Unit 35. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Family Planning: Education Maureen Paul, MD, MPH Maureen Paul, MD, MPH, Section Head The 5-week Family Planning rotation, which takes place during a BIDMC resident’s sec- Faculty ond year, provides exposure to family planning counseling and skills as part of the Ryan Siripanth Nippita, MD Program. Residents rotate through the Contraceptive Consult Clinic and perform ambu- Phillip Stubblefield, MD latory procedures including manual vacuum aspiration, medical abortion, and D&E cas- Clinical Faculty es. We are committed to training residents in abortion and contraception, as well as cultivating interests in public health, global and community health, research, and healthcare Shiao-Yu Lee, MD Boris Orkin, MD policy as integral components of family planning. All contraceptive options—hormonal, barrier, implant, and intrauterine methods—are provided by residents. A Family Planning– sponsored lecture series covers a wide range of topics, emphasizing the epidemiological evidence underlying current practice and new technologies in fertility regulation. BIDMC OB/GYN Annual Report 2013 36. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Family Planning: Clinical Care and confidential reproductive health care, providing women with pregnancy options counseling, first- and second-trimester abortion services (medical abortion, vacuum aspiration, and D&E), and comprehensive contraception counseling and provision. The BIDMC Contraceptive Consult Clinic caters to women with complex medical conditions or psychosocial situations. In addition, the BIDMC Family Planning Ambulatory Procedure Clinics provide management of early miscarriage, first-trimester surgical abortion, and early medical abortion. Offsite family planning experiences include Women’s Health Services and the Dimock Center, which expose residents to the variety of ways family planning Siripanth Nippita, MD services are delivered to heterogeneous populations. BIDMC OB/GYN Annual Report 2013 Family Planning clinical care focuses on comprehensive, safe, 37. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Reproductive Endocrinology and Infertility: Education Kim Thornton, MD, Division Director Alan Penzias, MD, Fellowship Director Kim Thornton, MD Reproductive Endocrinology and Infertility (REI) offers a robust educational program. Clinical Faculty IVF, the program’s principal clinical site. New patient and follow-up consultations; minor Michael Alper, MD office procedures such as ultrasound, sonohysterography, and hysterosalpingograms; Steven Bayer, MD ambulatory surgery; and advanced reproductive technology procedures are among the Brian Berger, MD experiences provided. Residents are also responsible for REI patient care at BIDMC, in- Merle Berger, MD cluding medical management of inpatients, gynecologic surgery, and ambulatory pa- Alice Domar, PhD tient care for the fellow-led Reproductive Endocrinology Ambulatory Clinic. Monthly Benjamin Lannon, MD conferences at BIDMC, in addition to monthly Boston IVF Grand Rounds, a lecture se- Selwyn Oskowitz, MD ries held at Boston IVF, and a monthly Boston IVF journal club provide ample learn- David Ryley, MD ing opportunities for understanding the latest topics in reproductive endocrinology and Rita Sneeringer, MD infertility. Residents and fellows are encouraged to become involved in clinical and/or Alison Zimon, MD basic research projects, and they may have opportunities to attend national meetings and present their research. BIDMC OB/GYN Annual Report 2013 During a 5-week rotation, second-year residents participate in clinical services at Boston 38. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Age of women ‹ 35 35 — 37 38 — 40 41 — 42 Number of cycles 908 536 572 311 Average number of embryos transferred 1.9 2.1 2.6 3.4 Percentage of transfers resulting in live births 35.6 27.5 19.5 17.6 Percentage of live births with twins 26.6 18.7 20 17.4 Percentage of live births with triplets or more 1.0 0.8 3.2 0 *Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2010 Assisted Reproductive Technology Fertility Clinic Success Rates Report. Atlanta: U.S. Department of Health and Human Services; 2012. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 Boston IVF IVF Success Rate and Live Births—Fresh Embryos from Non-Donor Eggs* 39. BIDMC OB/GYN • Clinical Age of women ‹ 35 35 — 37 38 — 40 41 — 42 Number of transfers 192 112 89 31 Percentage of transfers resulting in live births 22.4 24.1 20.2 12.9 Boston IVF IVF Success Rate and Live Births—Donor Eggs* Fresh Embryos Thawed Embryos Number of transfers 145 86 Percentage of transfers resulting in live births 46.9 21.4 *Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2010 Assisted Reproductive Technology Fertility Clinic Success Rates Report. Atlanta: U.S. Department of Health and Human Services; 2012. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 Boston IVF IVF Success Rate and Live Births—Thawed Embryos from Non-Donor Eggs* 40. BIDMC OB/GYN • Clinical our community for the reproductive rights and options available for all patients impacted by infertility.” Kim Thornton, MD BIDMC OB/GYN Annual Report 2013 “Endocrinology and Infertility works to advocate within 41. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Reproductive Endocrinology and Infertility: Clinical Care Eleven board-certified reproductive endocrinologists staff the full-service, state-of-the-art clinical reproductive endocrine and infertility unit at Boston IVF. The clinic is one of the largest assisted reproductive technology programs in the United States, with faculty having assisted in over 30,000 births. Ovulation induction, intrauterine insemination, in vitro fertilization, intracytoplasmic sperm injection, Boston IVF has a robust third-party reproduction program that, in addition to offering traditional egg donation (fresh), was one of the first centers in the Northeast to offer patients frozen donor eggs. The clinic continues to offer a gestational carrier program, and its fertility preservation (oocyte and sperm cryopreservation) program is designed for patients with malignancies or who are concerned about reproductive aging and desire to preserve their reproductive options. Diagnostic and operative endoscopy (laparoscopy/hysteroscopy) for developmental and acquired abnormalities of the reproductive tract, and procedures to correct developmental uterine anomalies, uterine fibroids, and severe endometriosis, are among the surgical procedures performed. In addition to the main facility in Waltham, Massachusetts, Boston IVF has sites in Boston, Quincy, Maine, Rhode Island, and satellite clinics throughout New England. Recognizing the impact that stress has on fertility, REI offers care complementary to conventional medicine through the Domar Center for Complementary Medicine. Among the center’s offerings are specific mind/body techniques designed to elicit the relaxation response, acupuncture, yoga, and nutritional counseling, as well as a full range of mental health counseling services. BIDMC OB/GYN Annual Report 2013 blastocyst culture and embryo freezing, and preimplantation genetic diagnosis and screening programs are among the services offered. 42. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical BIDMC OB/GYN • Clinical Minimally Invasive Gynecologic Surgery: Education Hye-Chun Hur, MD, Division Director Hye-Chun Hur, MD Third-year BIDMC residents rotate with the Minimally Invasive Gynecologic Surgery settings for comprehensive training. Principles and surgical skills in pelvic/abdominal, vaginal, and minimally invasive procedures are taught progressively, an approach that Faculty allows residents to develop the competencies expected of well-trained gynecologists by Louise P. King, MD, JD the end of the 4-year curriculum. Training is enhanced by outside rotations at Mount Auburn Hospital, Needham, and Milton Hospital, as well as by ambulatory hysteroscopy and surgery in the Shapiro Clinical Center and in private offices. In addition to daily inpatient management and teaching rounds with the Gynecology Attending of the Week, teaching at the bedside and in the operating theater occurs with all cases. Weekly staff and resident conferences enhance evidence-based care, and monthly educational surgical meetings with a gynecologic surgical committee are used to discuss surgical planning for resident patients. BIDMC OB/GYN Annual Report 2013 Division’s physicians in the inpatient operating room as well as in ambulatory surgical 43. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Minimally Invasive Gynecologic Surgery: Education Other learning opportunities include monthly skills sessions in biannual intensive simulation workshops. Residents also participate in a structured Fundamentals of Laparoscopic Surgery Program that includes didactic and skills training in laparoscopic techniques—passing the cognitive and skills examination is a requirement during the third year of the residency program and offers the opportunity to be accredited in this area prior to completing their Ob/Gyn training. Residents interact with a tremendous number of minimally invasive surgical patients, resulting in our graduates consistently ranking in the 80th to 90th percentile of procedure numbers nationally. BIDMC OB/GYN Annual Report 2013 the simulation laboratory, bimonthly resident didactic series, and 44. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Minimally Invasive Gynecologic Surgery: Clinical Care Our priority is to establish a plan of care for patients that is specifically tailored to the individual’s needs—incorporating the mediBIDMC OB/GYN Annual Report 2013 cal issues at hand in the context of the patient’s clinical profile and well-being. Although a variety of treatment options exist for different gynecologic conditions, our role is to guide the patient to the right decision and treatment plan for her specific condition and life stage. Our minimally invasive gynecologic surgery specialists are fellowship-trained to perform advanced gynecologic surgeries using the latest techniques and equipment. We provide evidence-based care for women who require surgical management, including both traditional laparoscopic and robotic approaches, with procedures including hysterectomies, removal of ovaries and ovarian cysts, myomectomies, surgical treatment of endometriosis, and hysteroscopic sterilizations. 45. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical GYN Department Surgical Approach GYN Total Surgical Cases GYN LSC/HSC Surgical Cases GYN LSC/HSC Percentage LSC/HSC Cases Percentage Cases 50% 4000 2750 40% 40% 2894 2689 2711 43% 40% 2384 2397 2312 30% 2000 20% 1000 974 966 924 960 1076 1169 998 10% 0% 0 FY2007 FY2008 *October 2012 to July 2013, 10 Months FY2009 FY2010 FY2011 FY2012 FY2013* LSC/HSC - Laparoscopy and Hysteroscopy BIDMC OB/GYN Annual Report 2013 36% 35% 3000 40% 39% 46. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical GYN Department Hysterectomy Approach Robotic Laparoscopy Abdominal Hysterectomy Laparoscopy Vaginal Hysterectomy LSC/Robotic Percentage LSC/Robotic Cases Percentage Cases 250 82% 80 % 76% 197 64% 166 198 62% 57% 142 150 46% 100 94 115 110 41% 105 103 35 % 104 64 50 65 58 51 94 87 81 63 21% 42 23 39 33 25 12 0 0% FY2007 FY2008 *October 2012 to July 2013, 10 Months FY2009 FY2010 FY2011 FY2012 FY2013* Minimally Invasive Percentage = Laparoscopy + Robotic All Hysterectomies –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 200 74% 202 47. BIDMC OB/GYN • Clinical Female Pelvic Medicine and Reconstructive Surgery: Education Janet Li, MD, Section Chief Affiliated Mount Auburn Faculty Roger Lefevre, MD, Faculty Peter Rosenblatt, MD, Division Chief The Female Pelvic Medicine and Reconstructive Surgery section provides clinical train- Eman Elkadry, MD ing to medical students, residents, and fellows, as well as faculty development. A rela- Katharine Hanaway, MD tionship between BIDMC and Mount Auburn Hospital allows collaboration on research Lekha Hota, MD projects related to urogynecology and pelvic reconstructive surgery. Residents from BIDMC participate in urogynecologic procedures as part of their 4-year gynecology experience, and each third-year resident rotates at Mount Auburn in urogynecology for a 10-week immersive experience. Curricula emphasize minimally invasive and robotic urogynecologic surgery, as well as ambulatory care that includes office evaluations and treatment for pelvic floor disorders. BIDMC OB/GYN Annual Report 2013 Janet Li, MD 48. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical BIDMC OB/GYN • Clinical “Pelvic floor disorders can often Urinary incontinence, overactive bladder, interstitial cystitis, genitourinary fistulae, recurrent urinary tract infections, pelvic organ prolapse, fecal incontinence, and urethral disorders are among the pelvic floor disorders treated in women of all ages. The comprehensive evaluation and management offered includes inoffice testing (urodynamics and cystourethroscopy) and in-office treatments (tibial nerve stimulation, bladder instillations, and periurethral injections). The broad range of surgical treatments for pelvic floor disorders include abdominal, vaginal, laparoscopic, and robotic approaches. Surgeries include minimally invasive mid-urethral sling, hysterectomy, paravaginal cystocele repair, anterior/posterior colporrhaphy, uterosacral/sacrospinous ligament vaginal vault suspension, sacrocolpopexy, graft-augmented be devastating for women who suffer from symptoms. Our sensitive, team-based approach is designed to help patients navigate through the range of treatment options, thereby empowering women to regain active lifestyles on their own terms. We strive to provide exceptional, personalized, high-quality care.” Janet Li, MD repairs, and InterStim. BIDMC OB/GYN Annual Report 2013 Female Pelvic Medicine and Reconstructive Surgery: Clinical Care 49. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical FPMRS Surgical Approach** FPMRS Total Cases FPMRS LSC/HSC/Robotic Cases FPMRS LSC/HSC/Robotic Percentage LSC/HSC/Robotic Cases Percentage Cases 244 250 204 23 % 192 156 150 147 20% 19 % 18 % 15 % 100 10% 73 50 46 5% 4% 10 6 0 3% 2 13 45 26 2 0% FY2007 FY2008 *October 2012 to July 2013, 10 Months FY2009 FY2010 FY2011 FY2012 FY2013* **Coded as Incontinence, Prolapse, and Fistula BIDMC OB/GYN Annual Report 2013 200 30% 50. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Division of Urogynecology at Mount Auburn Hospital Cambridge, Massachusetts The Division of Urogynecology in the Department of Obstetrics and Gynecology at Mount Auburn Hospital in Cambridge, Massachusetts, is a large urogynecology and reconstructive pelvic surgery center that serves all of New England as a referral center for basic and complex evaluation and management of pelvic floor disorders such as uri- Faculty Anthony DiSciullo, MD nary and fecal incontinence, overactive bladder, and pelvic organ prolapse. The division Eman Elkadry, MD consists of four fellowship-trained urogynecologists, a minimally invasive gynecologic Katherine Hanaway, MD surgeon, three fellows in female pelvic medicine and reconstructive surgery, and a nurse Leka Hota, MD practitioner and two nurses who specialize in urodynamic and anorectal testing. The clinical investigation team has a full-time research coordinator. The division’s philosophy emphasizes nonsurgical as well as minimally invasive surgical procedures, including robotic and laparoscopic reconstructive surgery. BIDMC OB/GYN Annual Report 2013 Peter L. Rosenblatt, MD, Division Director 51. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Neonatology: Education DeWayne Pursley, MD, MPH, Chair The neonatal training program at BIDMC is one of four clinical/research training sites program of its kind in the United States. Fellows rotate through BIDMC, providing care to newborns and their families, and honing their patient management and team leadership skills in the Neonatal Intensive Care Unit (NICU), nurseries, delivery room, and for the high-risk antepartum consultation service. Each year, the Department of Neonatology offers an American Academy of Pediatrics– approved training course in neonatal resuscitation to all Ob/Gyn and anesthesia residents—first-year residents receive initial training, while all others receive annual refresher courses. Formal clinical training for Harvard Medical School students is also offered. During the core pediatrics rotation at Boston Children’s Hospital, third-year medical students focus on newborn medicine in a 1-week rotation through the BIDMC newborn nursery, and fourth-year students are offered a month-long subinternship in the NICU. BIDMC OB/GYN Annual Report 2013 for the Harvard Neonatal-Perinatal Medicine Fellowship program, the largest training 52. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Neonatology: Clinical Care The 48-bed NICU at BIDMC provides care to over 1,200 newborns each year—900 require admission, while the remainder are triaged to the newborn nursery. The multidisciplinary team of physicians, nurse practitioners, nurses, neonatal respiratory therapists, social workers, neonatal dieticians, occupational and BIDMC OB/GYN Annual Report 2013 physical therapists, and pharmacists are extensively trained in the care of high-risk newborns and provide a full range of services for neonatal patients and comprehensive support for their families. Through a tightly integrated consultation system with the maternal-fetal medicine staff, genetic counselors, and Boston Children’s Hospital pediatric subspecialists, the NICU team provides clinical input and tracks all maternal admissions likely to result in the delivery of a newborn requiring intensive care. The unit provides cutting-edge therapy, including therapeutic hypothermia and inhaled nitric oxide, as well as makes potentially groundbreaking clinical research protocols available to eligible patients. 53. –> Table of Contents Previous Section • Next Section Neonatology: Clinical Care Together with attending neonatologists and neonatal-perinatal An additional component of our clinical care is the Cochran New- fellows, nurse practitioners and physician assistants provide born Service in the newborn nursery, where we provide compre- around-the-clock coverage in the NICU and participate in the hensive care to those infants whose primary pediatric providers teaching of Harvard Medical School students as well as nurse are not members of the BIDMC staff. The department’s pediatri- practitioner and other preprofessional students. Neonatal-peri- cians, neonatologists, and pediatric nurse practitioners provide natal fellows play an important clinical role in the NICU, provid- care of the highest quality. All nursery babies undergo hearing ing triage, consultative, and admission support, as well as ongoing screening under a program that was among the first universal care. During monthly rotations, they continue to bring new knowl- newborn screening programs developed in the state. Car seat po- edge and clinical innovations to the department that support the sition and fit testing is also performed for indicated infants prior unit’s goal of providing care at the leading edge of medicine. to discharge. BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 54. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 55. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical The mission of the Department of Neonatology research program Recent research themes within the Department: is to advance neonatal health and health care through excellence •Determining the impact of nutrition on health and disease in the and innovation across the spectrum of clinical research. The pro- preterm infant gram is broadly aimed at improving the care provided to new- •Improving NICU patient safety through team training borns and their families through epidemiologic, health services, •Applying cost-effectiveness analysis to optimize NICU and translational research in these areas: improving outcomes of resource utilization NICU patients, graduates, and families; understanding the eco- •Understanding the role of racial and social disparities in nomic implications of neonatal care; improving care delivery; un- infant outcomes derstanding the mechanisms of prematurity complications; and •Determining whether dietary factors and epigenetic optimizing education in newborn care. modifications account for disparities in preterm birth The program has pioneered comparative quality assessment in •Advancing the integration of evolving information technologies neonatology through the development of the Score for Neona- into the delivery and evaluation of newborn care tal Acute Physiology (SNAP), a key illness severity normalization •Identifying barriers to early intervention enrollment for tool, to establish inter-institutional variations in care amenable to NICU graduates quality improvement efforts. Early work has fostered collabora- •Assessing the effectiveness of perinatal and neonatal tion among all Massachusetts NICUs and led to an active, state- health services on the health of very premature infants wide quality improvement collaboration, established and headed • Understanding the emotional burden of families with preterm by a BIDMC neonatologist. infants during and after discharge from the NICU BIDMC OB/GYN Annual Report 2013 Neonatology: Research 56. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Quality, Safety, and Performance Improvement: Clinical Services/Organization Toni Golen, MD, Vice Chair, Quality, Safety, and Performance Improvement Faculty Medical Director, Labor and Delivery and Postpartum Marc Kobelin, MD, Improving the safety of childbirth and women’s health care is the primary goal in the Di- Co-Chairperson, QA Committee vision of Quality, Safety, and Performance Improvement. This area became a formal divi- Susan Mann, MD, sion in 2011 with the naming of Dr. Toni Golen as vice chair, and the work of the division is Director of Team Training achieved through careful analysis of cases, identification of opportunities for systematic Neel Shah, MD, MPP process improvement, compliance with regulatory guidelines, and an environment of just culture. BIDMC’s institutional goal of eliminating preventable harm is embedded in quality improvement projects. Through teamwork, simulation, and transparency surrounding adverse events, we look critically at ourselves and identify opportunities to prevent adverse outcomes and improve patient satisfaction. BIDMC OB/GYN Annual Report 2013 Toni Golen, MD 57. –> Table of Contents Previous Section • Next Section Quality, Safety, and Performance Improvement: Quality Assurance Quality Improvement Traditional case review, project-based quality improvement, While the Quality Assurance Committee assesses individual and sentinel event analysis make up the structure of our patient cases, leadership committees (Quality Improvement) develop safety program. The Ob/Gyn Quality Assurance Committee—in- systems to implement process improvement on a broader scale. cluding attending physicians, residents, and nurses, represent- Many ideas for quality improvement projects are generated by ing all specialties—chooses cases based on indicators defined by the case reviews performed by the Quality Assurance Commit- the Joint Commission, ACOG, and the Harvard Risk Management tee. Gaps in systems-based practice are identified. Examples of Foundation. Additionally, staff members submit specific concerns recent process improvements put into action include postpartum regarding a patient’s care to the committee. Committee members vaccination to prevent the spread of pertussis, standardized pro- serve as volunteers and commit to the goals of monitoring and cesses to prevent retained surgical items, integrating LEAN mo- enhancing quality patient care. dalities for improving patient safety during cesarean delivery, and introducing blunt needles to decrease accidental needle sticks. BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 58. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 59. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical BIDMC’s Department of Obstetrics and Gynecology helps lead The ability to measure quality is an essential element of quality the national movement to systematically improve patient safety improvement and patient safety. Our goal is to identify opportu- and health care quality. In 2007, we received the John M. Eisen- nities for improvement, measure our current state, set goals, and berg Award for Patient Safety and Quality from the Joint Com- then achieve them. mission, an award that recognizes leadership and dedication in To that end, one of our latest advances organizationally is a Joint innovations to improve patient care and safety. Also in 2007, Informatics Fellowship. The use of bioinformatics is essential to Blue Cross Blue Shield of Massachusetts awarded us its very first creating a safer environment for patients. Our first fellow is Dr. Health Care Excellence Award, created to recognize exceptional Neel Shah, MPP, an Ob/Gyn who recently completed his resi- achievement in improving the safety and efficacy of health care dency and has a strong interest in the analysis and measurement in Massachusetts. Today, BIDMC has among the lowest Adverse of value in health care. We see value as part of the definition of Outcome Index ratings of any comparable tertiary hospital re- quality and seek to meld his interests and talents with our rich porting to the National Perinatal Information Center, a national, history and clinical activity. Dr. Shah has already garnered nation- nonprofit organization that collects data. As a direct result of our al attention with the nonprofit organization he founded, Costs work, there are now statewide initiatives in Massachusetts, Mary- of Care, and the textbook Understanding High Value Care. We land, and the District of Columbia to introduce obstetrical team anticipate that his work here will have national and international training. The model is replicable and widely adaptable for other impact. Dr. Shah is also working as part of Atul Gwande’s Ariadne healthcare organizations. Labs Health Systems Innovation. –> Table of Contents BIDMC OB/GYN Annual Report 2013 Quality, Safety, and Performance Improvement: Quality and Volume Growth of Services 60. Previous Section • Next Section BIDMC OB/GYN • Clinical Almost any department will have adverse outcome reviews. What on performance, will make decision making during crisis situa- differentiates us is the complexity of our quality improvement tions easier and more accurate. We also participate in the nation- process and our attention to a just culture—a nonpunitive en- al ACOG Simulation Consortium, where we are able to contribute vironment. When an unexpected outcome occurs, we focus on our knowledge about simulation and learn from others. a thorough analysis of events with an emphasis on uncovering We have also had great success with local improvements. systematic flaws that might make another patient vulnerable to a •We were early adopters of having a hard stop when it comes to similar event in the future. We then set about making sustained elective delivery. Over the last 4 years, we have continually dem- and meaningful systemic changes. onstrated an extremely low rate (reported nationally through As part of our emphasis on systematic improvement, we utilize LeapFrog) of elective deliveries prior to 39 weeks. simulation and drills to teach protocols and guidelines to the •We have seen a steady decrease in the rate of cesarean deliver- frontline worker. We apply what we learn to the next drill in a ies at BIDMC. As a quality metric we measure nulliparous, term, continuous loop of improvement. A recent improvement involved singleton, and vertex (NTSV) cesarean delivery rates. emergency cesarean delivery. Through standardized work, we •We have focused on surgical site infection prevention by creat- have demonstrated the ease of prioritizing the initial count to ing “bundles,” or steps in patient care. Examples include the prevent retained surgical items. timely and appropriate use of perioperative antibiotics, preoper- While drills typically take place on our clinical units, events are ative chlorhexidine soap, and judicious hair removal. We moni- held regularly at the BIDMC state-of-the-art Simulation Center. tor compliance with our bundles and provide feedback to pro- We believe that mimicking high-acuity events in a safe environ- viders who do not complete the required steps. ment, in a structured clinical scenario with immediate feedback –> Table of Contents BIDMC OB/GYN Annual Report 2013 Growth of Services continued 61. Previous Section • Next Section BIDMC OB/GYN • Clinical Simulation training for staff and faculty is a key aspect of our Since 2007, the BIDMC Obstetrics Simulation has grown from culture of safety and participation, and training is mandatory. We a simple exercise involving shoulder dystocia to a comprehen- are a national leader in our simulation programs, which are based sive, multidisciplinary program that includes complex clinical on the belief that teamwork and communication come first, with scenarios; a rich collection of high-acuity, low-frequency events; clinical and technical skills superimposed upon that foundation. immediate standardized feedback; structured debriefing; and a Our programs incorporate feedback and debriefings. Our obste- combination of high- and low-fidelity models. Learners are asked tricians and trainees undergo annual obstetrical simulation train- to demonstrate knowledge, technical skill, and teamwork behav- ing, and our trainees perform semi-annual gynecologic surgical ior appropriate for these obstetrical events. Objectives of the pro- skills simulation. We host other institutions as part of our active gram are: membership in the ACOG Simulation Consortium. Obstetrics staff •To provide a safe environment to demonstrate and improve members must complete simulations once yearly. The Depart- teamwork communication and care with a particular focus on ment of Obstetrics and Gynecology has signed an agreement with high-acuity, low-frequency events. CRICO Harvard Risk Management that participation be linked to •To provide individual feedback in a structured, nonpunitive credentialing. environment by using an objective assessment tool. •To provide related didactic education to physicians and nurses regarding high-risk, low-frequency obstetrical emergencies. BIDMC OB/GYN Annual Report 2013 Quality, Safety, and Performance Improvement: Simulation Training Obstetrics 62. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 63. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical Obstetrics continued •To provide an open forum for exchange among obstetrical attending physicians, residents, nurses, anesthesiologists, and ancillary staff. •To allow learners to demonstrate and exercise knowledge of local guidelines and protocols to bring about safe and expeditious care during obstetrical emergencies (e.g., the massive transfusion protocol). BIDMC OB/GYN Annual Report 2013 Quality, Safety, and Performance Improvement: Gynecology Twice yearly, all residents participate in an intensive 3-hour simulation experience to learn surgical techniques and participate in intensive electrosurgical skills hands-on training. The structured Fundamentals of Laparoscopic Surgery (FLS) Program includes didactic and skills training in laparoscopic techniques. Our residents are mandated to achieve accreditation via the FLS Cognitive and Skills Examination as a graduation requirement, and BIDMC requires FLS certification for advanced laparoscopy and robotic privileging. 64. –> Table of Contents Previous Section • Next Section Phyllis West, RN, MSN Nursing Phyllis West, RN, MSN, Associate Chief Nurse Jane Smallcomb, RN, MS, Clinical Director BIDMC’s Ob/Gyn Nursing staff is committed to caring for the health of women over their full life cycle. Obstetrical nurses provide childbirth education and expert care to patients in the Labor and Delivery Unit, Newborn Nurseries, High-Risk Antepartum and Post-Partum Units, and Neonatal Intensive Care Unit. New mothers receive one-on-one teaching as well as certified lactation support. Our gynecologic nurses provide expert postoperative care, including management of complex gynecologic surgical and oncology patients while addressing patients’ emotional and physical well-being. Jane Smallcomb, RN, MS BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 65. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical family-centered and our goal is to maintain a balance of expertise and innovation with an environment that is welcoming and nurturing for you and your family.” Phyllis West, RN, MSN BIDMC OB/GYN Annual Report 2013 “Our nursing philosophy is anchored in care that is 66. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Clinical 67. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical BIDMC OB/GYN Annual Report 2013 Social Work 68. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Clinical BIDMC OB/GYN • Clinical Social Work Barbara Sarnoff Lee, LICSW, Ob/Gyn social workers have expertise in women’s health issues across the developmen- Director of Social Work and tal life cycle, with specialized knowledge in high-risk pregnancies, perinatal bereave- Patient/Family Engagement ment, pregnancy termination, HIV/AIDS in women, gynecological cancers, child welfare Ob/Gyn Social Workers issues, substance abuse, domestic violence, and menopause. Staff from the Department Betsy Barnet, LICSW of Social Work provide counseling, consultation, and education to BIDMC patients, fami- Nina Douglas, LICSW lies, and staff, as well as assist patients in locating and accessing community programs Susan Remy, LICSW and services. Sheleagh Somers-Alsop, LICSW The department sponsors the Center for Violence Prevention and Recovery, which pro- Gail Wolfsdorf, LICSW vides counseling and advocacy services for those whose lives have been touched by vio- Community Resource Specialist lence. The program includes SafeTransitions, a domestic violence intervention program, Glady Thomas the Rape Crisis Intervention Program, and a community violence intervention program. BIDMC OB/GYN Annual Report 2013 Social Work 69. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 Education 70. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Maternal-Fetal Medicine Fellowship Steven J. Ralston, MD, MPH, Fellowship Director Sarosh Rana, MD, Associate Fellowship Director Current Fellows The Maternal-Fetal Medicine Fellowship is a 3-year American Board of Ob- Academic Year 2013−2014 stetrics Melissa March, MD and Gynecology (ABOG)−approved clinical and research training program. Fellows spend 12 months on clinical rotations, 18 months on research, Kedak Baltajian, MD and 6 months of additional clinical time on electives and subspecialty exploration. Scott Shainker, DO A mentoring team guides each fellow according to individual goals and interests. Excellent basic and clinical research opportunities are offered, as well as extensive Program Graduate 2013 clinical experience in high-risk obstetrics, prenatal genetics, sonography, and ultra- Where Are They Now? sound-guided procedures. Fellows complete all of the ABOG requirements to obtain William Schnettler, MD, subspecialty board certification. Faculty member at TriHealth in Ohio BIDMC OB/GYN Annual Report 2013 Sarosh Rana, MD 71. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Current Fellows Academic Year 2013−2014 Kathryn Humm, MD Werner Neuhausser, MD, PhD Kristi Maas, MD Program Graduate 2013 Where Are They Now? Kara Nguyen, MD, RMA Philadelphia in Mechanicsburg, PA; affiliate of Pinnacle Health System Reproductive Endocrinology and Infertility Fellowship Alan Penzias, MD, Fellowship Director In the Reproductive Endocrinology and Infertility Fellowship, participants learn skills to embark on academic career paths in which they can lead both basic and clinical research programs. In addition, in this 3-year, ABOG-approved training program, fellows use their reproductive endocrinology and infertility skills in a clinical setting. Faculty expertise in reproductive medicine, surgery, and genetics, as well as pediatric and adolescent reproductive medicine, assists fellows in developing a solid foundation of clinical skill while achieving a specific area of expertise. BIDMC OB/GYN Annual Report 2013 Alan Penzias, MD 72. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Female Pelvic Medicine and Reconstructive Surgery Fellowship Training physicians to provide expert care in improving the quality of life for women with pelvic floor dysfunction is the chief educational objective of the Female Pelvic Medicine Current Fellows and Reconstructive Surgery Fellowship. The 3-year program, located at Mount Auburn Academic Year 2013−2014 Hospital/BIDMC, is approved by the Accreditation Council for Graduate Medical Educa- Amos Adelowo, MD, MPH tion (ACGME). The program covers outpatient urogynecologic assessment and treatment, Sybil Dessie, MD office-based procedures, and appropriate surgical candidate selection, with an emphasis Emily Von Bargen, DO on various treatment options and patient counseling. Additionally, a comprehensive ap- Program Graduate 2013 proach to surgical management, including preoperative and postoperative management, is emphasized. Surgical training in both clinical and surgical settings includes laparo- Where Are They Now? Sonia Adams, MD scopic, vaginal, and abdominal procedures, as well as robotic surgery. Research is an St. Elizabeth Medical Center, important and well-integrated portion of the curriculum with the availability of research Brighton, MA mentorship and support. BIDMC OB/GYN Annual Report 2013 Eman Elkadry, MD Eman Elkadry, MD, Fellowship Director 73. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Obstetrics and Gynecology Residency Program Hope Ricciotti, MD, Program Director Monica Mendiola, MD, Assistant Program Director Yvonne Gomez-Carrion, MD, Director of the Resident Surgical Practice Ronald Marcus, MD, Co-Director of the Resident Ambulatory Practice Celeste Royce, MD, Co-Director of the Resident Ambulatory Practice Anastasia Koniaris, MD, Associate Director of the Resident Ambulatory Practice Susan Kilbride, Manager, Graduate Medical Education Yvonne Gomez-Carrion, MD Martina DiNapoli, Program Coordinator BIDMC OB/GYN Annual Report 2013 Monica Mendiola, MD 74. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Residency Program Each year BIDMC’s Residency Program provides world-class training in Ob/Gyn for a select group of 5 residents. The principal training hospital, Beth Israel Deaconess Medical Center, is located adjacent to the Harvard working closely with our dedicated faculty and staff, see patients in ambulatory clinics, learn state-of-the-art surgical techniques including minimally invasive and robotic surgery, and provide obstetric care to just under 5,000 patients every year. In a level of training uniquely focused on the residents, they work one on one with faculty members in all subspecialty areas—maternal-fetal medicine, gynecologic oncology, female pelvic medicine and reconstructive surgery/urogynecology, reproductive endocrinology and infertility, family planning, and minimally invasive gynecologic surgery. Residents also have the opportunity to work in community health centers in Boston neighborhoods, or to explore global health issues through the Global and Community Health track. BIDMC OB/GYN Annual Report 2013 Medical School campus in the Longwood Medical Area. Here residents, 75. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Residency Program continued Teaching innovations such as simulation exercises for team training, obstetrical emergencies and laparoscopic surgery, and the Resident-as-Teacher Program all help to train the next generation of medical educators. The program’s reBIDMC OB/GYN Annual Report 2013 quired academic research component includes faculty consultation and support throughout a research project’s design, institutional review board approval, and statistical analysis. Additionally, residents have 2 months of elective time, with funding for project expenses. We take great pride in training our residents to pursue excellence in their endeavors, always with respect for diversity and empathy for the individual patient and family experience. –> Table of Contents 76. Previous Section • Next Section BIDMC OB/GYN • Education Administrative Chief Resident Lisa Hofler, MD, MPH, Administrative Chief Resident Each year faculty and residents elect one Administrative Chief Resident, an honor given to the resident who demonstrates leadership, professionalism, and clinical excellence, to the faculty, and help develop innovative teaching programs. Dr. Kristin Bixel served in the 2012–2013 academic year, and Dr. Lisa Hofler is serving in the current 2013–2014 academic year. “BIDMC provides excellent clinical and surgical training, with a focus on patient-centered care. The teamwork within the hospital and the supportive learning environment of the department create an exceptional residency experience.” Lisa Hofler, MD, MPH BIDMC OB/GYN Annual Report 2013 as well as the interpersonal skills needed to lead the residency program, serve as liaison 77. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Current Residents PGY 1: Class of 2017 Maria Fradinho, MD Academic Year 2013–2014 Erin Brooks, MD, MPH Faculty Physician at Chief Residents: Class of 2014 Olivia Chang, MD, MPH Harvard Vanguard Katharine Barnes, MD Jessica Kuperstock, MD Medical Associates, Lara Harvey, MD, MPH Kari Plewniak, MD Copley Practice Lisa Hofler, MD, MPH Elizabeth Roberts, MD Boston, MA Kristin Hung, MD Where are They Now? Julia Head, MD Class of 2013 Faculty Physician at Brigham & Women's PGY 3: Class of 2015 Sarah Averbach, MD Margaret Chory, MD Working a year at Bowdoin Hospital/Harvard Emily Holden, MD Street Health Center Vanguard Medical Yetunde Ibrahim, MD Entering Fellowship in Family Planning Associates, Kenmore Practice Annie Liu, MD University of California–San Francisco Boston, MA Nandini Raghuraman, MD Kristin Bixel, MD PGY 2: Class of 2016 Working a year at South Cove Faculty Physician at South Shore Community Health Center Women's Health pursuing Fellowship in Weymouth, MA Katie Armstrong, MD Katie Johnson, MD Zoe McKee, MD Bri Anne McKeon, MD Stephanie-Marie Jones, MD Gynecologic Oncology Boston, MA Sara Won, MD –> Table of Contents BIDMC OB/GYN Annual Report 2013 Lily Wu, MD 78. Previous Section • Next Section BIDMC OB/GYN • Education Medical Student Education Katharyn Meredith Atkins, MD, Clerkship Director Malcolm Mackenzie, MD, Associate Clerkship Director L. Renata Vicari, Clerkship Coordinator BIDMC exposes third-year students to the depth and breadth of experiences that occur in women’s reproductive healthcare delivery. Our goals are to provide wide-ranging opportunities to develop and refine clinical reasoning and procedural skills and to promote awareness and understanding of cultural differences in women’s health and reproductive care. We want students to understand their role within a healthcare team and the value of systems of care, and encourage them to be active, self-directed learners. Reading patient histories before providing care and developing a reflective attitude toward their work are just two of the important skills that help students understand our responsibility Katharyn Meredith Atkins, MD as caregivers through the range of women’s life experiences. BIDMC OB/GYN Annual Report 2013 The Harvard Medical School Ob/Gyn Core Clerkship Program at 79. –> Table of Contents Previous Section • Next Section Martina DiNapoli, Residency Coordinator L. Renata Vicari, Clerkship Coordinator BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Education 80. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Education Medical Student Education continued Students rotate on teams caring for patients in labor and delivery, in the postpartum units, and in gynecology inpatient service. Ob/Gyn generalists volunteer to be the Teaching Attending of the Day and guide students in learning about the care of women during labor and delivery. Each student is paired with an Ob/Gyn generalist core preceptor and attends weekly ambulatory sessions designed to promote both continuity in patient care and in student learning. In addition to grand rounds and resident-run didactic sessions on each service, there are also 2 to 3 hours of weekly didactic sessions, led by faculty and senior residents/fellows, on topics agreed upon by the Clerkship Committee, which comprises the clerkship directors integration of these specialties into student learning. Additional sessions on physical examinations, suturing, teamwork, and knot tying promote skill acquisition. Fourth-year Harvard Medical School students and selected students from outside institutions may take these advanced electives: •Obstetrics Subinternship •Women’s Health in Urban •Female Pelvic Medicine and Toni Golen, MD, Vice Chair, Community Settings Reconstructive Surgery Quality, Safety, and Performance Lucy Chie, MD, Director, Roger Lefevre, MD, Improvement Community Health Consortium Course Director, FPMRS •Gynecology Oncology •Reproductive Endocrinology Chris Awtrey, MD, and Infertility Division Director, Kim Thornton, MD, Gynecologic Oncology Division Director, REI BIDMC OB/GYN Annual Report 2013 at all of the Harvard Medical School teaching sites. Multidisciplinary conferences with Psychiatry and Radiology help to promote the 81. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 Research 82. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Research Michele Hacker, ScD, MSPH, Director, Program in Epidemiologic Research Laura Dodge, MPH, Research Assistant Miriam Haviland, MSPH, Research Assistant Basic science as well as translational, clinical, public health, and medical education research projects that support the interests and expertise so valued by the department are all supported by the Program in Epidemiologic Research. Mentorship and assistance with Michele Hacker, ScD, MSPH study design, protocol development, institutional review board approval, study implementation, data collection and management, data analysis, manuscript preparation, and grant writing are all provided, with an emphasis on the research endeavors of residents, fellows, and junior faculty. Residents and fellows routinely present at national and international meetings and publish in peer-reviewed journals. Projects include prospective and retrospective observational studies, randomized controlled trials, mixed-methods surveys, and experimental animal models. BIDMC OB/GYN Annual Report 2013 Anna Merport Modest, MPH, Research Assistant 83. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Research continued Recent topics have evaluated: the cervix with transvaginal ultrasonography •botulinum toxin injections for chronic pelvic pain •in vitro fertilization outcomes in young women •simulation training for minimally invasive surgery and the pathogenesis of preeclampsia has led to exciting new findings and potential clinical therapies, and an ongoing study of gene expression in pregnancies complicated by intrauterine growth restriction holds similar promise. obstetric complications Epidemiology and public health policy as it relates to women’s •a structured curriculum to teach accurate assessment health among the vulnerable and underserved, locally and of the cervix with transvaginal ultrasound internationally, have special emphasis in the department. Each academic year concludes with the department’s Resident Research Day, where our residents have been honored for their outstanding projects. Resident-initiated projects include: • investigation of patient-collected samples for HPV testing among women with limited access to medical care in Boston • multidisciplinary team approach to reducing the incidence of Collaborative efforts with other departments and institutions cesarean delivery in China have also advanced research and increased our understanding of • evaluation of postpartum IUD placement in Uganda disease and the delivery of health care. For example, a project on BIDMC OB/GYN Annual Report 2013 •the timing of voiding on the ability to accurately assess 84. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Research Faculty Lev Perelman, PhD, Director of The Center for Advanced Biomedical Imaging and Photonics Sarosh Rana, MD, Director of Perinatal Research Research continued Research Coordinator Faculty also collaborate with academic, Research Nurse governmental, and nongovernmental partners to broaden our understanding of women's health needs in humanitarian crises. Understanding sexual violence BIDMC OB/GYN Annual Report 2013 Saira Salahuddin, PhD, MBBS, Dawn McCullough, RN, Affiliated Research Scientists S. Ananth Karumanchi, MD, PhD, Department of Medicine in the eastern Democratic Republic of Yunping Li, MD, Congo, gender inequitable practices in Department of Anesthesia South Sudan, and postelection violence in Jonathan Hecht, MD, PhD, Kenya are among current collaborations. Department of Pathology 85. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Research 86. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Research collaboration between the Departments of Obstetrics going, and although drug-based therapies for preeclampsia may and Gynecology and Medicine at BIDMC has led to discoveries still be a few years away, researchers are optimistic. to help diagnose and eventually treat preeclampsia—a disease Other preeclampsia research includes an evaluation of the patho- that complicates 5% of pregnancies worldwide and is a cause of genesis of the excess cardiovascular disease noted in women maternal and fetal mortality. Researchers first found that sFlt-1, with a history of preeclampsia. Investigators are also working on a molecule that occurs naturally in the placenta, may cause pre- noninvasive techniques to evaluate pregnancy in an animal model eclampsia when it is overabundant. Further research, stemming of preeclampsia. And, a BIDMC Ob/Gyn researcher is co-leading from collaboration with the Hospital for Sick Children in Toronto, a multicenter randomized controlled clinical trial across several discovered that a second protein, soluble endoglin, when com- hospitals in the United States and Canada to evaluate the role of bined with sFlt-1, escalates preeclampsia to a life-threatening optimal blood pressure management for patients with gestational state. The work has led to BIDMC patent filings on methods of hypertension. This research program is directed by renal special- diagnosing and treating preeclampsia. BIDMC researchers are ist Dr. S. Ananth Karumanchi, Howard Hughes Medical Institute testing the hypothesis that these two molecules can be used as Investigator, who collaborates with Maternal-Fetal Medicine biomarkers in various clinical settings to help clinicians make a Specialist Dr. Sarosh Rana. more prompt and accurate diagnosis. Prospective studies are on- BIDMC OB/GYN Annual Report 2013 Preeclampsia and Hypertensive Disorders of Pregnancy 87. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Reproductive Endocrinology Research The Division of Reproductive Endocrinology and Infertility the NIH, are published, and researchers are participating in the conducts a robust array of both basic science and clinical NIH-funded FORTT trial to determine the best course of fertility research projects. Goals in the laboratory at Boston IVF include treatment for women of advanced reproductive age. understanding the fundamental aspects of oocyte maturation Stem Cell Research tion genetic diagnosis techniques holds promise for strategies to improve IVF outcomes and reduce the burden of multiple pregnancies. The division collaborates with the Harvard Stem Cell Institute and the Department of Stem Cell and Regenerative Biology. Dr. Kevin Eggan’s lab focuses on how developmental/environmental cues induce heritable variation in chromatin structure and how Clinical research focuses on outcomes related to assisted repro- variation regulates developmental potency, cell fate, and gene ductive technology. Drs. Michele Hacker and Alan Penzias have expression. The lab uses nuclear transfer and other approaches led efforts to perform rigorous analysis of the Boston IVF patient to develop human embryonic and induced pluripotent stem database, which contains records on 52,000+ in vitro fertilization cell lines that carry the genes responsible for human neurode- cycles. Other recent projects include estimating the cumulative generative disease. Dr. Eggan’s publication in Science, “Induced pregnancy rate of live born multiples following IVF and evaluat- pluripotent stem cells generated from patients with ALS can be ing the influence of endometrial thickness and progesterone level differentiated into motor neurons,” was cited by Time as the Top on outcomes of assisted reproductive technology. Results of the Medical Breakthrough of 2008. FASTT trial, the largest single-center fertility study funded by BIDMC OB/GYN Annual Report 2013 and preservation through vitrification. The study of preimplanta- 88. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Reproductive Endocrinology Research BIDMC OB/GYN Annual Report 2013 Ovarian Aging Division researchers bridge basic science with clinical research through the use of a discarded blood sample bank established in early 2008. The samples, paired with clinical outcomes of the patients, provide a powerful asset for establishing biomarkers of reproductive health. The study dovetails with our basic science research efforts on ovarian aging and the impact of disease states, including polycystic ovary syndrome, on reproductive success. 89. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research The Center for Advanced Biomedical Imaging and Photonics Studying Subcellular Morphology with CLASS Microscopy in the Department of Obstetrics and Gynecology is directed by Confocal light absorption and scattering spectroscopic (CLASS) Professor Lev T. Perelman. Through its three main research pro- microscopy is a novel way to use optical imaging techniques for grams, the center develops and uses a variety of tools and plat- noninvasive monitoring of embryonic cells on the submicron forms for in vivo optical biomedical imaging. scale with no exogenous labels. The human embryo’s develop- In Vivo Optical Detection of Preinvasive Cancer ment and response to environmental factors could be monitored Developing an optical system to perform rapid optical scanning progressively at all critical stages using CLASS microscopy. For and multispectral imaging of the entire epithelial surface of vari- example, when cells are in metaphase, CLASS could provide in- ous organs in the reproductive and gastrointestinal tracts, and formation concerning the number and shape of chromosomes. presenting a diagnosis in near real time, is the purpose of this Since measurement is nondestructive and requires no exogenous program. This approach, vastly superior to the present strategy of chemicals, a given embryo in vitro could be monitored over time performing random biopsies, provides a powerful tool for screen- before implantation. Such progression studies are not possible ing large populations of patients for early precancerous changes. with currently available techniques. The instrument was pilot tested in the esophagus at BIDMC, where for the first time in the world, it successfully guided biopsy—detecting and mapping sites of invisible dysplasia missed by the current standard of care. BIDMC OB/GYN Annual Report 2013 Optical Diagnosis of Disease 90. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Research 91. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Optical Diagnosis of Disease Optical Spectroscopic Technique for Noninvasive Prenatal Diagnosis Noninvasive prenatal diagnosis utilizing fetal cells circulating in maternal peripheral blood has received much attention, since it poses no risk to the fetus. Although several fetal cell types have BIDMC OB/GYN Annual Report 2013 been targeted, the search has focused on fetal nucleated red blood cells (fNRBC). Because of the low concentration of fNRBC in maternal blood, and interference by adult nucleated red blood cells (aNRBC), along with the failure to find broadly applicable identifiers that can differentiate fNRBC from aNRBC, reliable use of viable fNRBC in amounts sufficient for clinical use remains a challenge. We have demonstrated that fNRBC optical properties provide a unique optical biomarker that is based on the lightscattering spectroscopic signatures of fNRBC and may enable isolation of these cells from maternal peripheral blood samples, with the goal of developing a minimally invasive prenatal genetic testing technique. 92. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research The department conducts educational research projects utilizing but critical obstetrical events to determine the optimal training simulation, virtual patients, standardized patients, and innovative frequency and the perceived effect of the program to techniques in medical education. perform clinical care. Improving Handoff of Patients Obstetrical Virtual Patient Project Dr. Mimi Fradinho, then a chief resident, and Dr. Toni Golen de- Dr. Hope Ricciotti developed a normal pregnancy virtual patient, signed and implemented a quality assurance program to improve funded by the Macy Foundation as part of a series produced by communication during resident hand off, resulting in a more ef- the Shapiro Institute for Education and Research. The education- ficient and structured process. al effect of the OB Virtual Patient as a teaching tool was evaluated Communicating Bad News Simulation Training Module in a randomized controlled study of Harvard medical students. Dr. Jo Marie Janco, then a third-year resident, Dr. Hope Ricciotti, Resident as Teacher Program and faculty from the Division of Medical Oncology collaborated Drs. Hope Ricciotti and K. Meredith Atkins lead a program using to implement and evaluate simulated training modules for deliv- videotaped, simulated medical student teaching encounters to ering bad news to patients. train residents, with immediate faculty feedback and self-reflec- Obstetrical Emergencies Simulation Training tion. The project has led to a similar Resident as Teacher in the Dr. Toni Golen, vice chair of Quality, Safety, and Performance Im- O.R. Project, still in its initial phase, under the direction of Dr. Ric- provement, and Dr. Mary Vadnais, then a Maternal-Fetal Medicine ciotti and recent resident graduate Dr. Lauren Cadish. Fellow, evaluated a simulation training program for uncommon BIDMC OB/GYN Annual Report 2013 Medical Education Research 93. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Research Simulated Surgical Skills Training Teaching Scripts in Ob/Gyn Dr. Hye-Chun Hur, division director of Minimally Invasive Gy- Dr. K. Meredith Atkins is leading a project to investigate the use of necologic Surgery, is involved in several educational studies teaching scripts to improve medical student instruction. evaluating the role of simulation teaching and assessment for Robotic Surgery Curriculum gynecologic surgical training. Areas of study include traditional Dr. Janet Li, section head of Female Pelvic Medicine and laparoscopic suturing, electrosurgery, and robotic surgery. Reconstructive Surgery, is developing a curriculum to teach ro- Simulator Development botic surgery to residents. The project will evaluate residents’ Dr. Christopher Awtrey, division director of Gynecologic Oncol- attitudes and opinions regarding robotic surgery before and after ogy, developed and evaluated a novel laparoscopic simulator to the training. train residents in pelvic surgery suturing skills. The Pelv-sim is a modified box trainer that can be used to hone suturing skill before seeing patients in the operating room. Currently, Dr. Awtrey is developing and testing a laparoscopic sacrocolpopexy box trainer that simulates one of the most advanced procedures for the treatment of women with pelvic organ prolapse. BIDMC OB/GYN Annual Report 2013 Medical Education Research 94. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 Social Mission 95. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Social Mission Community Health Consortium Lucy Chie, MD, MPH, Director The Community Health Consortium leads and develops projects in obstetrics and gynecology for the Boston area’s culturally diverse population of urban and suburban women. A network of community health centers staffed by our core teaching faculty and serving women from a wide range of ethnic backgrounds, as well as the LGBT community, function as ambulatory sites for the resident practice and medical student programs. programs, public health research projects, educational endeavors, and public service. A Harvard Medical School student elective entitled “Ob/Gyn and Women’s Health in Urban Community Settings” is also offered as a fourth-year elective option. “Everyone deserves to receive the health care they need to live life to the fullest. We are committed to providing the highest quality of care and access to all women.” Lucy Chie, MD, MPH BIDMC OB/GYN Annual Report 2013 Healthcare leaders from each center come together quarterly at BIDMC to plan clinical 96. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Social Mission Global and Community Health Program Jennifer Scott, MD, MBA, MPH, Director Whether in Roxbury, Massachusetts, or Sub-Saharan Africa, BIDMC OB/GYN Annual Report 2013 much of women's health is shaped by social, economic, and political inequities. The goal of the Global and Community Health Program is to help faculty, staff, and students develop a global understanding of women's health and to foster culturally competent care practices that meet the needs of the communities we serve. We are committed to advancing reproductive health care in an equitable, ethical, and dynamic manner, both locally and globally. To that end, we support innovative approaches and models to global health delivery that engage community partners and build capacity. We encourage faculty, staff, and students to participate in service-based projects and research initiatives in collaboration with local and international partners. Residents may also 97. –> Table of Contents Previous Section • Next Section Global and Community Health Program continued choose to conduct their longitudinal clinics in Boston’s medically underserved communities at health centers such as the Dimock Center and South Cove Community Health Center. We encourage residents to contribute their second- and third-year elective time toward global and community health initiatives. Numerous opportunities exist with the department, the BIDMC Global Health curriculum, and the broader community at Harvard Medical School and Harvard School of Public Health. Mentorship programs for faculty, staff, and students allow meaningful contributions to women’s health as providers, researchers, and advocates. BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Social Mission 98. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 BIDMC OB/GYN • Social Mission 99. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Social Mission The Parent Connection Christine Sweeney, LICSW, Program Manager Since 1999 the Parent Connection, an award-winning, complimentary postpartum service, has helped families anticipate and adjust to life after birth. parents weekly throughout the first 12 weeks postdelivery to offer encouragement and support and to help connect families to appropriate resources. Mentors are sometimes “As the only hospital-based The Parent Connection provides families a continuum of care after their delivery. program of its kind in Boston, Mentoring Moms is a perfect example of a ‘human first’ approach that gives me such a sense of personal and professional pride. That most of our mentor volunteers are program graduates—I couldn’t ask for a better evaluation.” Through personal outreach and support, it exemplifies our values of patient- and family- Christine Sweeney, LICSW the first to help a new mom recognize she is experiencing symptoms consistent with a postpartum mood disorder, and they help new moms to feel they are not alone in their struggles. New Moms groups at several community locations provide moms an opportunity to share experiences, ask questions, and reduce isolation. One group specifically for working moms meets during evening hours. The program offers a monthly workshop called “Becoming Parents” to help expectant couples anticipate and plan for the initial weeks at home with their newborn. centered care. BIDMC OB/GYN Annual Report 2013 In the program’s Mentoring Mom service, trained and supervised volunteers call new 100. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Social Mission Service-Based Learning and Research Projects Recent Global Health Initiatives Ongoing Global Health Initiatives, 2012−2013 •Clinical resident elective in Botswana at Scottish •Clinical resident elective in Nepal with Nyaya Health •BIDMC interdepartmental collaboration and consultation on Livingstone Hospital global women’s health initiatives in India, Zimbabwe, Gabon, •Clinical support of the urogynecologic surgical program at Botswana, and China Panzi Hospital in the Democratic Republic of Congo in collabo- •Collaboration with the Human Resources for Health Program ration with the Harvard Humanitarian Initiative in Rwanda to support Ob/Gyn graduate medical education •Obstetric ultrasound training and research collaboration on a and training Gates Foundation−funded program in Ghana •Obstetric anesthesia clinical and research collaboration in •Family planning research at Mulago Hospital in China Kampala, Uganda •Maternal-fetal medicine research collaboration in Haiti •Collaboration with WHO working groups to inform maternal •Gender-based violence, human rights violations, and gender and child health policies and reproductive endocrine and equality research in the Democratic Republic of Congo, infertility policies Kenya, and South Sudan in collaboration with academic, •Academic medical education collaborations with partners in governmental, and nongovernmental international partners China and Vietnam BIDMC OB/GYN Annual Report 2013 International 101. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Social Mission Service-Based Learning and Research Projects Community Health Initiatives • Mentoring, clinical preceptorships, and research supervision serving immigrants from East Asia; recent projects include health literacy and hepatitis B infection in pregnancy •Mentoring, clinical preceptorships, and research supervision for residents at the Dimock Center, which serves African American and Latina populations in Roxbury; recent projects include HPV vaccination, teen pregnancy, and IUD utilization •HPV detection study and health education curriculum for an urban shelter population •Health education and outreach for women in correctional facilities and transitional programs •Collaboration with community-based organizations to improve access to women’s health care for minority patient populations BIDMC OB/GYN Annual Report 2013 for residents at South Cove Community Health Center, 102. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Social Mission Global Women’s Health Program Areas of Activity Ukraine Geneva, Switzerland Boston China Korea Japan Nicaragua India Haiti Ghana South Sudan Uganda DR Congo Rwanda Gabon Philippines Kenya Zambia Botswana South Africa BIDMC OB/GYN Annual Report 2013 Nepal Mexico 103. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN Annual Report 2013 Living in Boston 104. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Living in Boston Living in Boston BIDMC is located in one of the most vibrant, livable cities in the United States. Boston is institutions but offers so much more in terms of history and culture. Puritan colonists from England founded the town in 1630, and since that time the city has played a central role in the political, commercial, financial, religious, and educational development of the New England region. Today, you’ll see the city’s full history reflected in its diverse neighborhoods, well-preserved architecture, and major historical sites. The city is also modern and stylish, rich in culture, and beautifully situated near mountains and the ocean. Theater, dance, art, music, and sports are all within walking or biking distance—or a quick ride on our public transportation system. An evening at Boston Symphony Hall is just a “T” stop away or you can stroll down the street to catch a game at Fenway Park, home of the world champion Boston Red Sox. Boston is a clean and safe city that mirrors the quality and distinction you’ll find at BIDMC. Whether you are new to Boston or a long-time resident, we think you’ll find living in “the hub” an exciting experience. BIDMC OB/GYN Annual Report 2013 known worldwide for its state-of-the-art medical facilities and world-class educational 105. –> Table of Contents Previous Section • Next Section BIDMC OB/GYN • Publications Publications Adams SR, Durfee S, Katz D, Pettigrew C, Jennings R, Ecker J, House M, Benson C, Wolfberg A. Accuracy of ultrasound to predict estimated weight in fetuses with gastroschisis. Journal of Ultrasound in Medicine. 2012;31(11):1753-8. Berger BM, Phillips JA. Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement. Journal of Assisted Reproduction and Genetics. 2012;29(3):237-42. Adams SR, Hacker MR, Merport Modest A, Rosenblatt PL, Elkadry EA. Informed consent for sacrocolpopexy: is counseling effective in achieving patient comprehension? Female Pelvic Medicine and Reconstructive Surgery. 2012;18(6):352-6. NIHMSID #480644. Bhan I, Powe CE, Berg AH, Ankers E, Wenger JB, Karumanchi SA, Thadhani RI. Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney International. 2012;82(1):84-9. Adelowo AO, Hacker MR, Merport Modest A, Elkadry EA. Do symptoms of voiding dysfunction predict urinary retention? Female Pelvic Medicine and Reconstructive Surgery. 2012;18(6):344-7. PMCID: PMC3512564. Boivin J, Domar AD, Shapiro DB, Wischmann TH, Fauser BC, Verhaak C. Tackling burden in ART: an integrated approach for medical staff. Human Reproduction. 2012;27(4):941-50. Awtrey CS. Nomograms for predicting endometrial cancer recurrence. Gynecologic Oncology. 2012;125(3):513-4. Branch-Elliman W, Golen TH, Gold HS, Yassa DS, Baldini LM, Wright SB. Risk factors for Staphylococcus aureus postpartum breast abscess. Clinical Infectious Diseases. 2012;54(1):71-7. Bartels S, Kelly J, Scott J, Leaning J, Mukwege D, Joyce N, Vanrooyen M. Militarized sexual violence in South Kivu, Democratic Republic of Congo. Journal of Interpersonal Violence. 2013;28(2):340-58. Bartels SA, Scott JA, Leaning J, Kelly JT, Joyce NR, Mukwege D, Vanrooyen MJ. Demographics and careseeking behaviors of sexual violence survivors in South Kivu province, Democratic Republic of Congo. Disaster Medicine and Public Health Preparedness. 2012;6(4):393-401. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis. Critical Care Medicine. 2012;40(11):3034-41. Dodge LE, Haider S, Hacker MR. Knowledge of state-level abortion laws and regulations among front-line staff at facilities providing abortion services. Women’s Health Issues. 2012;22(5):e415-20. BIDMC OB/GYN Annual Report 2013 Peer-Reviewed Manuscripts of Original Research 106. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Peer-Reviewed Manuscripts of Original Research Domar AD, Conboy L, Denardo-Roney J, Rooney KL. Lifestyle behaviors in women undergoing in vitro fertilization: a prospective study. Fertility and Sterility. 2012;97(3):697-701. Fadare O, Parkash V, Dupont WD, Acs G, Atkins KA, Irving JA, Priog EC, Quade BJ, Quddus MR, Rabban JT III,Vang R, Hecht JL. The diagnosis of endometrial carcinomas with clear cells by gynecologic pathologists: an assessment of interobserver variability and associated morphologic features. The American Journal of Surgical Pathology. 2012;36(8):1107-18. Faupel-Badger JM, Wang Y, Staff AC, Karumanchi SA, Stanczyk FZ, Pollak M, Hoover RN, Troisi R. Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African American preeclamptic and uncomplicated pregnancies. Cancer Causes and Control. 2012;23(5):779-84. Haggerty CL, Seifert ME, Tang G, Olsen J, Bass DC, Karumanchi SA, Ness RB. Second trimester antiangiogenic proteins and preeclampsia. Pregnancy Hypertension. 2012;2(2):158-63. Helderman JB, O'Shea TM, Kuban KC, Allred EN, Hecht JL, Dammann O, Paneth N, McElrath TF, Onderdonk A, Leviton A; ELGAN Study Investigators. Antenatal antecedents of cognitive impairment at 24 months in extremely low gestational age newborns. Pediatrics. 2012;129(3):494-502. Hota LS, Hanaway K, Hacker MR, Disciullo A, Elkadry E, Dramitinos P, Shapiro A, Ferzandi T, Rosenblatt PL. TVT-Secur (Hammock) versus TVT-Obturator: a randomized trial of suburethral sling operative procedures. Female Pelvic Medicine and Reconstructive Surgery. 2012;18:41-45. NIHMSID #480627. Hung KJ, Scott J, Ricciotti HA, Johnson TR, Tsai AC. Community-level and individual-level influences of intimate partner violence on birth spacing in Sub-Saharan Africa. Obstetrics and Gynecology. 2012;119(5):975-82. Kane SE, Hecht JL. Endometrial intraepithelial neoplasia terminology in practice: 4-year experience at a single institution. International Journal of Gynecologic Pathology. 2012;31(2):160-5. Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation. 2012;125(22):2728-38. Karipcin FS, Moragianni VA, Milette B, Kinzer DR, Thornton KL, Barrett B, Penzias AS. Effect of steroid and antibiotic treatment during assisted hatching on IVF outcomes. Human Fertility (Camb). 2012;15(4):205-9. BIDMC OB/GYN Annual Report 2013 Dodge LE, Haider S, Hacker MR. Using a simulated patient to assess referral for abortion services in the United States. Journal of Family Planning and Reproductive Health Care. 2012;38(4):246-51. 107. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Peer-Reviewed Manuscripts of Original Research Khankin EV, Mandala M, Colton I, Karumanchi SA, Osol G. Hemodynamic, vascular, and reproductive impact of FMS-like tyrosine kinase 1 (FLT1) blockade on the uteroplacental circulation during normal mouse pregnancy. Biology of Reproduction. 2012;86(2):57. Lannon B*, Choi B*, Hacker MR, Dodge LE, Malizia BA, Barrett CB, Wong WH, Yao MWM, Penzias A. Predicting the risk of multiple birth after in vitro fertilization—double embryo transfer. Fertility and Sterility. 2012;98:69-76. Li F, Hagaman JR, Kim HS, Maeda N, Jennette JC, Faber JE, Karumanchi SA, Smithies O, Takahashi N. eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. Journal of the American Society of Nephrology. 2012;23(4):652-60. Lu J, Lian G, Zhou H, Esposito G, Steardo L, Delli-Bovi LC, Hecht JL, Lu QR, Sheen V. OLIG-2 overexpression impairs proliferation of human Down syndrome neural progenitors. Human Molecular Genetics. 2012;21(10):2330-40. Mijal RS, Holzman CB, Rana S, Karumanchi SA, Wang J, Sikorskii A. Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery. Journal of Maternal-Fetal and Neonatal Medicine. 2012;25(7):1135-41. Moragianni VA, Hacker MR, Craparo FJ. The impact of length of second stage of labor on shoulder dystocia outcomes: a retrospective cohort study. Journal of Perinatal Medicine. 2012;40:97-100. Moragianni VA, Jones SML, Ryley DA. The effect of body mass index on the outcomes of first assisted reproductive technology cycles. Fertility and Sterility. 2012;98(1):102-8. Newman LR, Brodsky DD, Roberts DH, Pelletier SR, Johansson A, Voller CM Jr, Atkins KM, Schwartzstein RM. Developing expert-derived rating standards for the peer assessment of lectures. Academic Medicine. 2012;87(3):356-63. Ogbechie OA, Hacker MR, Dodge LE, Patil MM, Ricciotti HA. Confusion regarding cervical cancer screening and chlamydia screening among sexually active young women. Sexually Transmitted Infections. 2012:88(1):35-37. NIHMSID 480621. Patten IS*, Rana S*, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac angiogenic imbalance leads to peri-partum cardiomyopathy. Nature. 2012;485:333-9. PMCID: PMC3356917. *Contributed equally to the work. BIDMC OB/GYN Annual Report 2013 Khankin EV, Hacker MR, Zelop CM, Karumanchi SA, Rana S. Intravital highfrequency ultrasonography to evaluate cardiovascular and uteroplacental blood flow in mouse pregnancy. Pregnancy Hypertension. 2012;2(2):84-92 PMCID: PMC3337759. 108. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Peer-Reviewed Manuscripts of Original Research Qiu L, Turzhitsky V, Chuttani R, Pleskow DK, Goldsmith JD, Guo LY, Vitkin E, Itzkan I, Hanlon EB, Perelman LT. Spectral imaging with scattered light: from early cancer detection to cell biology. IEEE Journal of Selected Topics in Quantum Electronics. 2012;18:1073-83. Rajakumar A, Cerdeira AS, Rana S, Zsengeller Z, Edmunds L, Jeyabalan A, Hubel CA, Stillman IE, Parikh SM, Karumanchi SA. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension. 2012;59(2):256-64. Rana S, Cerdeira AS, Wenger J, Salahuddin S, Lim KH, Ralston SJ, Thadhani RI, Karumanchi SA. Plasma concentrations of soluble endoglin versus standard evaluation in patients with suspected preeclampsia. PLoS One. 2012;7(10):e48259. Rana S, Hacker MR, Modest AM, Salahuddin S, Lim KH, Verlohren S, Perschel FH, Karumanchi SA. Circulating angiogenic factors and risk of adverse maternal and perinatal outcomes in twin pregnancies with suspected preeclampsia. Hypertension. 2012;60(2):451-8. PMCID: PMC3432569. Rana S, Powe CE, Salahuddin S, Verlohren S, Perschel FH, Levine RJ, Lim KH, Wenger JB, Thadhani R, Karumanchi SA. Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia. Circulation. 2012;125(7):911-9. Ricciotti HA, Dodge LE, Head J, Atkins KM, Hacker MR. A novel resident-asteacher training program to improve and evaluate obstetrics and gynecology resident teaching skills. Medical Teacher. 2012;34(1):e52-7. Rosenblatt PL, Apostolis CA, Hacker MR, Disciullo A. Laparoscopic supracervical hysterectomy with transcervical morcellation and sacrocervicopexy: initial experience with a novel surgical approach to uterovaginal prolapse. Journal of Minimally Invasive Gynecology. 2012;19(6):749-755. NIHMSID #480636. Schnettler WT, Hacker MR, Barber RE, Rana S. Management of abnormal serum markers in the absence of aneuploidy or neural tube defects. Journal of Maternal-Fetal and Neonatal Medicine. 2012;25(10):1895-8. NIHMSID #480635. Scott J, Polak S, Kisielewski M, McGraw-Gross M, Johnson K, Hendrickson M, Lawry L. A mixed-methods assessment of sexual and gender-based violence in eastern Democratic Republic of Congo to inform national and international strategy implementation. International Journal of Health Planning and Management. 2012 May 20 [Epub ahead of print]. BIDMC OB/GYN Annual Report 2013 Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice. Journal of Clinical Investigation. 2012;122(2):759-76. 109. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Peer-Reviewed Manuscripts of Original Research Skiadas CC, Duan S, Correll M, Rubio R, Karaca N, Ginsburg ES, Quackenbush J, Racowsky C. Ovarian reserve status in young women is associated with altered gene expression in membrana granulosa cells. Molecular Human Reproduction. 2012;18(7):362-71. Stern J, Hickman RN, Kinzer D, Penzias A, Ball D, Gibbons WE. Can the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) be used to accurately report clinic total reproductive potential (TRP)? Fertility and Sterility. 2012;97(4):886-9. Tang JR, Karumanchi SA, Seedorf G, Markham N, Abman SH. Excess soluble vascular endothelial growth factor receptor-1 in amniotic fluid impairs lung growth in rats: linking preeclampsia with bronchopulmonary dysplasia. American Journal of Physiology—Lung Cellular and Molecular Physiology. 2012;302(1):L36-46. Vadnais MA, Dodge LE, Awtrey CS, Ricciotti HA, Golen TH, Hacker MR. Assessment of long-term knowledge retention following single-day simulation training for uncommon but critical obstetrical events. Journal of MaternalFetal and Neonatal Medicine. 2012;25(9):1640-5. NIHMSID #480631. Vadnais MA, Rana S, Quant HS, Salahuddin S, Dodge LE, Lim KH, Karumanchi SA, Hacker MR. The impact of magnesium sulfate therapy on angiogenic factors in preeclampsia. Pregnancy Hypertension. 2012;2(1):16-21. PMCID: PMC32541114. Vikse BE, Irgens LM, Karumanchi SA, Thadhani R, Reisæter AV, Skjærven R. Familial factors in the association between preeclampsia and later ESRD. Clinical Journal of the American Society of Nephrology. 2012;7(11):1819-26. Vinokurov VA, Muradov AV, Getmanskiy M, Qiu L, Vitkin E, Itzkan I, Perelman LT. Nonspherical gold nanoparticles as bright light scattering labels with narrow plasmon lines. Advanced Sciences and Technologies. 2012;86:51-58. Wang A, Holston AM, Yu KF, Zhang J, Toporsian M, Karumanchi SA, Levine RJ. Circulating antiangiogenic factors during hypertensive pregnancy and increased risk of respiratory distress syndrome in preterm neonates. Journal of Maternal-Fetal and Neonatal Medicine. 2012;25(8):1447-52. Young BC, Hacker MR, Dodge LE, Golen TH. Timing of antibiotic administration and infectious morbidity following cesarean delivery: incorporating policy change into workflow. Archives of Gynecology and Obstetrics. 2012;285:1219-24. Young B, Hacker MR, Rana S. Physicians' knowledge of future vascular disease in women with preeclampsia. Hypertension in Pregnancy. 2012;31(1):508. PMCID: PMC3227747. BIDMC OB/GYN Annual Report 2013 Shahul S, Rhee J, Hacker MR, Gulati G, Mitchell JD, Hess P, Mahmood F, Arany Z, Rana S, Talmor D. Subclinical left ventricular dysfunction in preeclamptic women with preserved left ventricular ejection fraction: a 2D speckle tracking imaging study. Circulation: Cardiovascular Imaging. 2012;5:734-739. NIHMSID# 480638. 110. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Peer-Reviewed Manuscripts of Original Research Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. Journal of Histochemistry and Cytochemistry. 2012;60(7):521-9. Adelowo A, Hacker MR, Merport A, Elkadry E. Do symptoms of voiding dysfunction predict urinary retention? 2012. Presented at the 38th Annual Scientific Meeting of the Society of Gynecologic Surgeons. Adelowo A, Hacker MR, O’Neal E, Hota L. Underlying factors contributing to the delay in patients seeking care for pelvic floor dysfunction. 2012. Poster Presentation, AUGS 33rd Annual Scientific Meeting. Adams SR, Dodge LE, Dramitinos P, Elkadry E. Do patient goals vary with stage of prolapse? A follow up study of goal achievement. 2012. Presented as a poster at the annual meeting of the American Urogynecologic Society. Averbach S, Lester F, Fortin J, Byamugisha J, Goldberg A, Kakaire O. Acceptability of the IUD among women who opted out of a randomized controlled trial of intracesarean insertion of the Copper-T 380A in Kampala, Uganda. 2012. Presented as a poster at the 20th World Congress of Gynecology and Obstetrics. Adams SR, Hacker MR, Rosenblatt P, Merport A, Elkadry E. Informed consent for sacrocolpopexy: is counseling effective in achieving patient comprehension? 2012. Presented as an oral presentation at the 38th Annual Scientific Meeting of the Society of Gynecologic Surgeons. Bixel K, Hur HC, Merport Modest A, Kiang M, Singer S. Impact of perceptions of patient safety on planning and implementation of surgical safety checklists. 2012. Presented at the 41st AAGL Global Congress on Minimally Invasive Gynecology. Adams SR, McKinney JL, Rosenblatt, PL. Musculoskeletal pain and disorders among gynecologic surgeons. 2012. Presented as an oral presentation at the annual meeting of the American Association of Gynecologic Laparoscopists. Bixel K, Merport Modest A, McCann A. Treatment and outcomes of patients diagnosed with carcinoma confined to the abdomen. 2012. Presented as an oral presentation at the annual meeting of the New England Association of Gynecologic Oncologists. Conference Abstracts BIDMC OB/GYN Annual Report 2013 Yu XD, Branch DW, Karumanchi SA, Zhang J. Preeclampsia and retinopathy of prematurity in preterm births. Pediatrics. 2012;130(1):e101-7. 111. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Conference Abstracts Harvey LF, Barnes K, Hofler L, Hung K, Wu L, Hur HC. Analysis of patient characteristics and subsequent surgical intervention among a cohort of women trialing levonorgestrel intrauterine devices (IUDs) for medical indications. Journal of Minimally Invasive Gynecology. 2012;19(6S):S103-4. Presented as an oral presentation at the 41st AAGL Global Congress on Minimally Invasive Gynecology. Hawkins L, Schnettler W, Hacker M, Merport Modest A, Rodriguez D. Association of third trimester abdominal circumference with timing of delivery. 2012. Presented as an oral presentation at the American Institute of Ultrasound in Medicine, Annual Convention. Hawkins L, Schnettler W, Hacker M, Merport Modest A, Rodriquez D. Association of third trimester abdominal circumference with timing of delivery. 2012. Presented as an oral presentation at the 22nd World Congress on Ultrasound in Obstetrics. Hofler L, Merport Modest A, Dodge LE, Owen L, Hacker MR, Haider S. Patient satisfaction and procedure characteristics of uterine evacuation using a vacuum aspiration with and without sharp curettage. 2012. Presented as a poster at the annual meeting of the Central Association of Obstetricians and Gynecologists. Hofler L, Owen L, Dodge LE, Hacker MR, Haider S. Patient satisfaction and procedure wait times for uterine evacuation with manual and electric vacuum aspiration. 2012. Presented as a poster at the annual meeting of the Society for Family Planning. Lely TA, Salahuddin S, Holwerda KM, Karumanchi SA, Rana S. Circulating lymphangiogenic factors in preeclampsia. 2012. Presented as a poster at the 28th International Society for the Study of Hypertension in Pregnancy World Congress. Malizia BA, Dodge LE, Sisti JS, Penzias AS, Hacker MR. Increased body mass index (BMI) is a risk factor for poor fertilization among women undergoing in vitro fertilization (IVF). 2012. Presented as a poster at the annual meeting of the American Society of Reproductive Medicine. Moragianni VA, Alper MM. Recurrent pregnancy loss in a patient with sex chromosome mosaicism: a case report and review of the literature. 2012. Presented as a poster at the annual meeting of the Society of Gynecologic Investigation. Moragianni VA, Mullen A, Penzias AS, Berger BM. Antral follicle count measurement in oocyte donors is not associated with recipient IVF outcomes. 2012. Presented as a poster at the annual meeting of the Society for Gynecologic Investigation. BIDMC OB/GYN Annual Report 2013 Dessie S, Adams SR, Hacker MR, Merport Modest A, Elkadry EA. Bladder habits and attitudes in an ethnically diverse population. 2012. Presented as a poster at the annual meeting of the American Urogynecologic Society. 112. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Conference Abstracts Rana S, Hacker MR, Salahuddin S, Karumanchi SA. Angiogenic factors and the risk of adverse outcomes in twin gestation. 2012. Presented as a poster at the annual meeting of the Society for Gynecologic Investigation. Shapiro A, Dessie S, Hacker M, Awtrey C. Validation of a novel, camera-based, procedure specific, laparoscopic box-trainer. 2012. Presented as a poster at the annual meeting of the Society of Gynecologic Surgeons. Wu LH, Humm KC, Dodge LE, Sakkas D, Hacker MR, Penzias AS. IVF outcomes are paradoxically poorer under age 25. 2012. Presented as a poster at the annual meeting of the American Society of Reproductive Medicine. Yiu T, Averbach S, Hacker MR, Merport A, Walker H, Dimitrakoff J, Ricciotti H. The association between Mycoplasma genitalium and preterm delivery at an urban community health center. 2012. Presented as a poster at the Women’s Health Congress. Schaarschmidt W, Rana S, Stepan H. The course of sFlt1 and PlGF reflects different progression pattern in early- versus late-onset preeclampsia and HELLP syndrome. 2012. Presented as a poster at the 28th annual meeting of the International Society for the Study of Hypertension in Pregnancy World Congress. Other Publications Scott J, Averbach S, Merport Modest A, Hacker MR, Murphy M, Cornish S, Spencer D, VanRooyen M. An assessment of gender equitable norms in South Sudan. 2012. Presented as a poster at the annual Women’s Health Congress. Awtrey CS. Nomograms for predicting endometrial cancer recurrence. Comment on: Nomograms to predict isolated loco-regional or distant recurrence among women with uterine cancer. Gynecologic Oncology. 2012;125(3):513-4. Shahul S, Rhee JS, Rana S, Hacker MR, Mitchell J, Hess P, Mahmood F, Talmor D. Subclinical left ventricular dysfunction in preeclamptic women with preserved left ventricular ejection fraction: a 2D speckled tracking imaging study. 2012. Presented as a poster at the 28th International Society for the Study of Hypertension in Pregnancy World Congress. Bixel K, Silasi M, Zelop CM, Lim KH, Zsengeller Z, Stillman I, Rana S. Placental origins of angiogenic dysfunction in mirror syndrome. Hypertension Pregnancy. 2012;31(2):211-7. Cerdeira AS, Karumanchi SA. Angiogenic factors in preeclampsia and related disorders. Cold Spring Harbor Perspectives in Medicine. 2012;2(11). BIDMC OB/GYN Annual Report 2013 Rana S, Hacker M, Merport A, Salahuddin S, Verlohren S, Perschel F, Karumanchi A. Angiogenic factors and risk of preeclampsia related adverse outcomes in twin pregnancies. 2012. Presented as a poster at the 28th International Society for the Study of Hypertension in Pregnancy World Congress. 113. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Other Publications Fallat ME, Hertweck P, Ralston SJ. Surgical and ethical challenges in disorders of sexual development. Advanced Pediatrics. 2012;59(1):283-302. Garrett LA, Boruta DM II. Laparoscopic single-site radical hysterectomy: the first report of LESS type III hysterectomy involves a woman with cervical cancer. American Journal of Obstetrics and Gynecology. 2012;207(6)518.e1-2. Hagmann H, Thadhani R, Benzing T, Karumanchi SA, Stepan H. The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia. Clinical Chemistry. 2012;58(5):837-45. Hur HC. Incidence and patient characteristics of vaginal cuff dehiscence complications after hysterectomy. Up To Date. 2009–present (revised annually). Mackenzie M. Laparoscopic intracorporeal cinch knots: changing the square knot paradigm. Journal of Minimally Invasive Gynecology. 2012;19(2):225-35. March MI, Warsof SL, Chauhan SP. Fetal biometry: relevance in obstetrical practice. Clinical Obstetrics and Gynecology. 2012;55(1):281-7. Moragianni VA. Can we finally move away from the surgical diagnosis of endometriosis? Fertility and Sterility. 2012;98(3):609. Moragianni VA, Hamar BD, McArdle C, Ryley DA. Management of a cervical heterotopic pregnancy presenting with first-trimester bleeding: case report and review of the literature. Fertility and Sterility. 2012;98(1):89-94. Penzias AS. Recurrent IVF failure: other factors. Fertility and Sterility. 2012;97(5):1033-8. Quant H, Arden D, Takoudes T, Rana S. Angiogenic factors and pregnant woman with new onset seizures. Hypertension in Pregnancy. 2012;31(2):207-10. Konstantinopoulos PA, Awtrey CS. Management of ovarian cancer: a 75-yearold woman who has completed treatment. Journal of the American Medical Association. 2012;307(13):1420-9. Ralston SJ. Ethics of multifetal pregnancy reduction. Lahey Clinic Journal of Medical Ethics. 2011;18(3). Lowenstein L, Rosenblatt PL, Dietz HP, Bitzer J, Kenton K. New advances in urogynecology. Obstetrics and Gynecology International. 2012;2012:453059. Scott J, Averbach S, Merport Modest A, Hacker M, Cornish S, Spencer D, Murphy M, Parmar P. A gender lens on South Sudan: an assessment of gender inequitable norms and gender-based violence in South Sudan 2009–2011. Harvard Humanitarian Initiative and American Refugee Committee. July 2012. BIDMC OB/GYN Annual Report 2013 Cerdeira AS, Kopcow HD, Karumanchi SA. Regulatory T cells in preeclampsia: some answers, more questions? American Journal of Pathology. 2012;181(6):1900-2. 114. –> Table of Contents Previous Section BIDMC OB/GYN • Publications Other Publications Scott J, Kelly J. Gender-based violence and reproductive health in humanitarian crises and conflict. In: Oxford Handbooks. Oxford University Press. Submitted September 2012. Stillman IE, Karumanchi SA. Vasculitis is an antiangiogenic state. Journal of the American Society of Nephrology. 2012;23(1):8-10. Wang A, Karumanchi SA. Relaxin' with endothelial progenitor cells. Blood. 2012;119(2):326-7. BIDMC OB/GYN Annual Report 2013 Wellons MF, Fujimoto VY, Baker VL, Barrington DS, Broomfield D, Catherino WH, Richard-Davis G, Ryan M, Thornton K, Armstrong AY. Race matters: a systematic review of racial/ethnic disparity in Society for Assisted Reproductive Technology reported outcomes. Fertility and Sterility. 2012;98(2):406-9. 115. –> Table of Contents Previous Section w w w.bidmc.org/obg yn