Local Organizing Committee

Local Organizing Committee
Chair
Micaela Morelli
Members
Cristina Cadoni
Anna Carta
Marco Diana
Liana Fattore
Miriam Melis
Annalisa Pinna
Nicola Simola
Valentina Valentini
2
XVI CONGRESS of the Italian Society for Neuroscience
PRELIMINARY PROGRAM
Thursday 8 October 2015
16:30-17:50 Symposium 1
THE DRUNKEN SYNAPSE: FROM MOLECULAR AND
FUNCTIONAL ADAPTATIONS TO CLINICAL PRACTICE
Chair: Biggio Giovanni (Cagliari)
GABaergic medication in the treatment of alcohol use disorders: role
of sodium oxybate and baclofen
Addolorato Giovanni (Roma)
Neuroadaptive mechanisms in ethanol withdrawal: from spines to
spikes
Diana Marco (Sassari)
Gaba Mechanisms in alcohol-induced effects and neuroplasticity
Korpi Esa R. (Helsinki - Finland)
Increased alcohol consumption and synaptic plasticity in mouse
models of early-life stress
Sanna Enrico (Cagliari)
Symposium 2
Chair: Pistis Marco (Cagliari)
NEURAL ENCODING FOR AVERSION, STRESS AND
NEGATIVE STATES: ADVANCES IN NEUROPHYSIOLOGY AND
NEUROPHARMACOLOGY
PPAR-ALPHA: a potential new therapeutic target for mood disorders
De Montis Maria Grazielle (Siena)
Cellular mechanisms in the lateral habenula coding aversive states
Mameli Manuel (Paris - France)
The neural circuit for aversion in cannabinoid withdrawal
Muntoni Anna Lisa (Cagliari)
Early life stress and risk for psychopathology: a role for epigenetics
Riva Marco Andrea (Milano)
Cagliari October • 8th - 11th •2015
3
Thursday 8 October 2015
Symposium 3
PARKINSON’S DISEASE: A SPREADING PATHOLOGY?
Chairs: Spano PierFranco (Brescia) & Spillantini Maria Grazia (Cambridge - UK)
Prion-like properties of c-terminally truncated alpha-synuclein
Bellucci Arianna (Brescia)
Lysines, achilles’ heel in alpha-synuclein conversion to a neuronal
oligomeric endotoxin
Bubacco Luigi (Padova)
Putting a brake on aging to counteract parkinson’s disease
Decressac Mikael (Pozzuoli)
C-rel deficient mice, a mouse model of “spreading” pd-like pathology
Parrella Edoardo (Brescia)
Truncated human alpha-synuclein expression results in synaptic
dysfunction and dopaminergic cell death
Spillantini Maria Grazia (Cambridge - UK)
18:00-19:00 Opening of the Congress
Lecture 1 Huntington: the story of an ancient gene in search of a
better future
Elena Cattaneo (Milano)
19:00-20:30 Welcome Cocktail
Friday 9 October 2015
09:00-09:45 Lecture 2
ow we see and hear stuff: visual and auditory routes to
H
understanding the material properties of objects
Melvyn A. Goodale (London - Canada)
4
XVI CONGRESS of the Italian Society for Neuroscience
Friday 9 October 2015
10:00-11:20 Symposium 4
INNOVATIVE STRATEGIES FOR RESCUING TISSUE INJURY
INDUCED BY STROKE (UNDER 40)
Chair: Pignataro Giuseppe (Napoli)
Drug repurposing for immune modulation in ischemic stroke
Amantea Diana (Cosenza)
Epigenetic drugs to reduce post ischemic brain injury, a new
therapeutic approach targeting acetylation of nf-kappab and histones
Lanzillotta Annamaria (Brescia)
Ionic homeostasis and endogenous neuroprotection
Pignataro Giuseppe (Napoli)
Symposium 5
EARLY IN LIFE DRUG EXPOSURE: FUNCTIONAL CONSEQUENCES ON BRAIN DEVELOPMENT
Chair: Frau Roberto (Cagliari)
Shank3 insufficiency uncovers a role of vta in asds
Bellone Camilla (Lausanne - Switzerland)
Short-term abstinence from developmental exposure to cocaine
alters the glutamate synapse following acute stress: implication of
glucocorticoid receptor
Fumagalli Fabio (Milano)
Prenatal exposure to cannabinoids affects postnatal synaptic
properties and plasticity of excitatory transmission on dopamine
neurons of the ventral tegmental area
Melis Miriam (Cagliari)
The impact of adolescent cannabinoid exposure on brain maturation:
focus on epigenetic mechanisms
Rubino Tiziana (Busto Arsizio)
Cagliari October • 8th - 11th •2015
5
Friday 9 October 2015
Symposium 6
ROLE OF GLIAL CELLS IN THE CENTRAL MECHANISM
OF CHRONIC PAIN
Chair: Marinelli Silvia (Roma)
NGF and glial cells: an overlooked story
Capsoni Simona (Pisa)
Neuro-immune interactions in chronic pain
Malcangio Marzia (London - UK)
TRPV1 channels in the brain: modulation of microglia to neuron
communication in naive and neuropathic mice
Marinelli Silvia (Roma)
Transmission on dopamine neurons of the ventral tegmental area
Nykjaer Anders (Aarhus - Denmark)
Free oral communications session 1
11:20-11:40 Break
11:40-13:00 Symposium 7
BOOSTING CELL REPAIR IN NEURODEGENERATIVE
DISEASES: MOLECULAR AND CELLULAR MECHANISMS
AND TARGETING STRATEGIES
Chair: Marchetti Bianca (Catania)
euroinflammatory cytokines and their receptors as innovative targets:
N
restraint of neuronal damage and restoration of function in ad
Cantarella Giuseppina (Catania)
Implications of familial mutations for the pathogenesis and treatment of
neurodegenerative diseases
Harvey Kirsten (London - UK)
Targeting wnt signaling for dopaminergic (da) neurorepair in
parkinson’s disease: tripartite dialogue between da neuroprogenitors,
glial cells and the injured da neurons
Marchetti Bianca (Troina)
Stem cell-based modulation of innate and adaptive immune responses
in cns injury
Peruzzotti Luca (Cambridge - UK)
6
XVI CONGRESS of the Italian Society for Neuroscience
Friday 9 October 2015
Symposium 8
PHYSIOLOGY AND PHYSIOPATHOLOGY OF BDNF:
TOWARDS THE DEVELOPMENT OF NEW THERAPEUTIC
STRATEGIES FOR MAJOR NEURO-PSYCHIATRIC DISEASES
Chair: Baj G. (Trieste)
The “spatial and quantitative code” of bdnf variants: a therapeutic
target for the disorders of the nervous system
Baj Gabriele (Trieste)
Silencing BDNF expression with herpes simplex virus type-1 based
amplicon vectors in an experimental model of temporal lobe epilepsy
Falcicchia Chiara (Ferrara)
Arc expression is modulated post-transcriptionally by splicing of its
3’utr and bdnf signalling
Giorgi Corinna (Roma)
Environment-induced neuroplasticity changes in knock-in mice with the
human bdnf val66met polymorphism
Ieraci Alessandro (Milano)
Essential role of astroglial p75 ntr for ltp maintenance and visual
recognition memory
Vignoli Beatrice (Roma)
Symposium 9
CHANGES IN NEUROACTIVE STEROID LEVELS MAY
INDUCE BENEFICIAL AND DETRIMENTAL EFFECTS IN THE
NERVOUS SYSTEM
Chairs: Melcangi Roberto Cosimo (Milano) & Riva Marco Andrea (Milano)
Targeting neurosteroid pathways for the treatment of tourette
syndrome and impulse control
Bortolato Marco (Lawrence - USA)
Neonatal neuroactive steroid levels alteration: long term-effects on
behaviour in rats
Darbra Sonia (Barcelona - Spain)
Effect of finasteride treatment in the nervous system: clinical and
experimental observations
Melcangi Roberto Cosimo (Milano)
Cagliari October • 8th - 11th •2015
7
Friday 9 October 2015
Neurosteroids during development: implications for gaba-a receptor
function and stress sensitivity in adulthood
Porcu Patrizia (Cagliari)
Free oral communications session 2
13:00-14:00 Lunch
14:00-16:00 Poster Session 1
16:00-16:45 Lecture 3
Dopamine and synaptic plasticity: from motor to cognitive
dysfunctions
Paolo Calabresi (Perugia)
17:00-18:20 Symposium 10
INTRINSIC AND EXTRINSIC REGULATION OF
OLIGODENDROCYTE PROGENITOR CELL SELF-RENEWAL
AND DIFFERENTIATION
Chair: Boda Enrica (Torino)
Regulation of synaptic connectivity between gabaergic interneurons
and ng2 cells during cortical oligodendrogenesis
Angulo Maria Cecila (Paris - France)
Molecular mechanisms in oligodendroglioma infiltration and
malignancy
Appolloni Irene (Genova)
Balancing self-renewal and differentiation of the oligodendrocyte
progenitor pool: insights into cell intrinsic regulatory mechanisms
Boda Enrica (Torino)
New mechanisms regulating oligodendroglial differentiation: focus on
the GPR17 receptor and related micrornas
Lecca Davide (Milano)
8
XVI CONGRESS of the Italian Society for Neuroscience
Friday 9 October 2015
Symposium 11
RECENT ADVANCES IN THE UNDERSTANDING
OF L-DOPA-INDUCED DYSKINESIA: FOCUS ON
SEROTONIN, GLUTAMATE AND DOPAMINERGIC
TRANSMISSIONS IN ANIMAL MODELS OF
PARKINSON’S DISEASE
Chair: Carta Manolo (Cagliari)
The seretonin system in L-DOPA included dystinesia, from rats to
humans
Björklund Anders (Lund - Sweden)
Alteration of nmda receptor subunits as synaptic trait of L-DOPAinduced dyskinesia: molecular mechanisms and effect of
eltoprazine treatment
Gardoni Fabrizio (Milano)
Behavioural and electrophysiological characterization of
serotonergic 5-HT1A/1B agonist, eltoprazine, in experimental
l-dopa-induced dyskinesia
Picconi Barbara (Roma)
MTOR signaling in L-DOPA-induced dyskinesia
Usiello Alessandro (Napoli)
Motor neuron-immune system cross-talk in als: evidence and
consequences on the disease
Bendotti Caterina (Milano)
Symposium 12
THE COMPLEXITY OF MOTOR NEURON DISEASES
Chairs: Poletti Angelo (Milano)
Group i metabotropic glutamate receptors and neurotoxicity in
amyotrophic lateral sclerosis
Milanese Marco (Genova)
The involvement of muscle in sbma and als
Pennuto Maria (Trento)
The protein quality control system in motoneuron diseases
Rusmini Paola (Milano)
Free oral communications session 3
18:20-20:00 Posters session 2 & Wine and cheese
Cagliari October • 8th - 11th •2015
9
Saturday 10 October 2015
09:00-09:45 Lecture 4
Brain connectomics: exploring the connectome and
synaptome
Javier De Felipe (Madrid - Spain)
10:00-11:20 Symposium 13
NEUROTROPHINS IN PHYSIOLOGY AND PATHOLOGY:
NOVEL MOLECULAR AND CELLULAR PERSPECTIVES
(UNDER 40)
Chair: Cesca Fabrizia (Genova)
Kidins220/arms is a functional mediator of neurotrophin signaling
pathways in nervous system development, maturation and
plasticity
Cesca Fabrizia (Genova)
Communication is key: dissecting long-range neurotrophic
signaling
Deinhardt Katrin (Southampton - UK)
Neurotrophic-priming of glucocorticoid actions
Jeanneteau Freddy (Montpellier - France)
Single molecule imaging and tracking of neurotrophins and their
receptors in living neuronal cells
Marchetti Laura (Pisa)
BICD1 and dynein modulate long-range growth factor signalling
Terenzio Marco (Rehovot - Israel)
Symposium 14
PARKINSON’S DISEASE: FROM NEUROPATHOLOGY TO
PHARMACOLOGICAL AND NON PHARMACOLOGICAL
TREATMENT OF MOTOR COMPLICATIONS
Chair: Brambilla Riccarco (Milano)
Dyskinesia and neuroinflammation: evidence from pulsatile versus
continuous L-DOPA delivery
Carta Anna R. (Cagliari)
Approaches to the treatment of L-DOPA induced dyskinesia
based on ras-erk targeting: far from being a simple matter
Fasano Stefania (Milano)
10
XVI CONGRESS of the Italian Society for Neuroscience
Saturday 10 October 2015
Intensive rehabilitation in the treatment of L-DOPA-induced
dyskinesia
Frazzitta Giuseppe (Trescore Balneario)
Nitric oxide synthase inhibition decreases L-DOPA-induced
dyskinesia and the expression of striatal molecular markers in
pitx3−/− aphakia mice
Moratalla Rosario (Madrid - Spain)
Symposium 15
EATING DISORDERS: FROM BENCH TO BEDSIDE AND
RETURN – ISN SPONSORED SYMPOSIUM
Chair: Passani Beatrice (Firenze), Gaetani Silvana (Roma)
First evidence for a role of oleoylethanolamide in the regulation of
appetite in humans
Leweke Markus (Mannheim - Germany)
Animal models of eating disorders and obesity or food addiction
Lutz Thomas (Zurigo - Switzerland)
Role of the central histaminergic system in the hypophagic,
procognitive and antidepressant-like effects of the endogenous
ppar-a ligand oleoylethanolamide
Provensi Gustavo (Firenze)
The BclI receptor gene polymorphism (rs41423247) moderates
the association between childhood overweight, psychopathology,
and clinical outcomes in eating disorders patients: a 7 years follow
up study
Ricca Valdo (Firenze)
Role of oleoylethanolamide in the “gut-to-brain axis”: possible
implications for the treatment of obesity and eating disorders
Romano Adele (Roma)
Free oral communications session 4
11:20-11:40 Break
Cagliari October • 8th - 11th •2015
11
Saturday 10 October 2015
11:40-13:00 Symposium 16 NOSE AND GUT: OPEN DOORS TO THE BRAIN
Chair: Bentivoglio Marina (Verona)
Gut microbiota and brain: a mutual relationship
Fiorucci Stefano (Perugia)
The nasal cavity as railway of pathogens and toxins to the brain
Kristensson Frister (Stockholm - Sweden)
The enteric nervous system and the progression of parkinson’s
disease: facts and perspectives
Pizzi Marina (Brescia)
The olfactory mucosa in the diagnosis of prion and prion-like
neurodegenerative diseases: facts and perspectives
Zanusso Gianluigi (Verona)
Symposium 17
D-AMINO ACIDS, FROM BRAIN PHYSIOLOGY TO
DISORDERS
Chairs: Usiello Alessandro (Napoli) & Pollegioni Loredano (Varese)
Critical role of d-serine in synaptic plasticity relevant to cocaine
addiction
D’Ascenzo Marcello (Roma)
D-aspartate-based modulation of NMDA receptor
neurotransmission: preclinical implication
Errico Francesco (Napoli)
Of the importance of space and time in the functions of the nmda
receptor coagonists in the hippocampus
Mothet Jean Pierre (Marseille - France)
D-serine metabolism in the brain: the role of d-amino acid oxidase
Sacchi Silvia (Varese)
Partial amelioration of hd symptoms in R6/2 mice treated with
CI-994, a class i selective hdac inhibitor
Basso Manuela (Trento)
12
XVI CONGRESS of the Italian Society for Neuroscience
Saturday 10 October 2015
Symposium 18
HDAC INHIBITION IN NEUROPROTECTION: NEW
CHANCE FOR THERAPY
Chair: Formisano Luigi (Napoli)
Dynamic epigenetic regulation of NCX1 expression in brain
ischemia and in ischemic brain preconditioning, by modification
of histone acetylation
Formisano Luigi (Napoli)
Role of parp and HDACS in hippocampal slice models of
ischemic preconditioning in vitro
Pellegrini - Giampietro Domenico Edoardo (Firenze)
Epigenetic and transcriptional dysfunction in ischemic brain
injury and huntington’s disease: from mechanisms to therapeutic
candidates
Yildirim Ferah (Berlin - Germany)
Free oral communications session 5
13:00-14:00 Lunch
14:00-16:00 Poster Session 3
16:00-16:45 Lecture 5
Immune proteins in brain development and synaptic plasticity
Michela Matteoli (Milano)
17:00-18:20 Symposium 19
INNOVATIVE STRATEGIES TO FOSTER BRAIN REPAIR
AFTER DAMAGE
Chairs: Caleo Matteo (Pisa) & De Simoni Maria Grazia (Milano)
Role of perineuronal nets in CNS plasticity and repair
Carulli Daniela (Torino)
Cagliari October • 8th - 11th •2015
13
Saturday 10 October 2015
Ischemic and pharmacological pre-conditioning and postconditoning: molecular mechanisms of neuroprotection and
neuroplasticity
Gerace Elisabetta (Firenze)
Robotic rehabilitation and plasticizing treatments for the recovery
of motor function after focal cortical stroke
Lai Stefano (Pisa)
Mesenchymal stromal cell therapy to foster endogenous
reparative mechanisms in the acute injured brain
Zanier Elisa R. (Milano)
Symposium 20
EMERGING ROLE OF EXTRACELLULAR VESICLES
IN THE BRAIN: IMPLICATIONS FOR INTERCELLULAR
COMMUNICATIONS, BIOMARKER DEVELOPMENT
AND THERAPY
Chairs: Verderio Claudia (Milano) & Benussi Luisa (Brescia)
Role of exosomes released by astrocytes overexpressing mutant
SOD1 in disease spreading and motor neuron pathology in
amyotrophic lateral sclerosis
Basso Manuela (Trento)
Extracellular vesicles isolated from bone marrow mesenchymal
stem cells display an anti-inflammatory effect in experimental
models of alzheimer disease
Coco Silvia (Milano)
Diagnostic role of EVs in neurodegenerative and
neuroinflammatory diseases
Furlan Roberto (Milano)
Shuttling of micrornas from glia-to-neurons: modulation of
neuronal gene expression
Prada Ilaria (Milano)
Possibilities and limitations of current technologies for
quantification of extracellular vesicles
Zarovni Natasa (Siena)
14
XVI CONGRESS of the Italian Society for Neuroscience
Saturday 10 October 2015
Symposium 21
MECHANISMS OF EMBRYONIC AND ADULT
NEUROGENESIS - GEI (GRUPPO EMBRIOLOGICO
ITALIANO) SPONSORED SYMPOSIUM
Chair: Tata Ada Maria (Roma)
Role for ppar transcription factors in the energetic metabolic
switch occurring during neurogenesis
Cimini Anna Maria (L’Aquila)
COUP-TFI functions in adult neurogenesis
De Marchis Silvia (Torino)
Altered serotonin homeostasis affects development and
maintenance of serotonergic neuronal circuitry
Pasqualetti Massimo (Pisa)
Ascidians as a simple model for the study of development and
evolution of vertebrate nervous system
Pennati Roberta (Milano)
Balancing self-renewal, differentiation and lineage-choice of
retinal progenitor cells in vivo
Poggi Lucia (Heidelberg - Germany)
Free oral communications session 6
18:20-20:00 Posters session 4 & Wine and cheese
Sunday 11 October 2015
09:00-09:45 Lecture 6
Dopamine and reward: the never ending story
Gaetano Di Chiara (Cagliari)
Cagliari October • 8th - 11th •2015
15
Saturday 10 October 2015
10:00-11:20 Symposium 22
DOPAMINE FUNCTIONS IN NEURODEGENERATION
AND PLASTICITY (UNDER 40)
Chair: Espinoza Stefano (Genova)
Role of nicotinic and dopamine d3 receptor crosstalk in the
regulation of dopaminergic neurons plasticity
Bontempi Leonardo (Brescia)
Identification and characterization of new regulators of the
dopamine system in the animal model C. Elegans
Di Schiavi Elia (Napoli)
Pronounced dopaminergic dysregulation in dopamine transporter
knockout rats
Leo Damiana (Genova)
Hdac inhibition reduces dopamine-dependent neurodegeneration
in a mouse model of dat-deficiency syndrome
Ronzitti Giuseppe (Evry - France)
Symposium 23
NEW TARGETS, TRANSCRIPTIONAL AND
TRANSDUCTIONAL FACTORS AS AN INNOVATIVE
STROKE RESCUING STRATEGY
Chair: Annunziato Lucio (Napoli)
Remyelination in stroke: new targets and new challenges to
implement repair and functional recovery
Abbracchio Maria Pia (Milano)
Targeting Transcriptional And Transductional Mechanisms
Controlling Na+/Ca2+ Exchanger (NCX) As New Strategy In Stroke
Intervention
Annunziato Lucio (Napoli)
Versatility of the complement system in stroke
De Simoni Maria Grazia (Milano)
Carbonic anhydrase IX and its interactome in hypoxia
Zambrano Nicola (Napoli)
16
XVI CONGRESS of the Italian Society for Neuroscience
Saturday 10 October 2015
Symposium 24
HCN CHANNELS IN THE PHYSIOLOGY AND
PATHOLOGY OF THE NERVOUS SYSTEM
Chair: Mannaioni Guido (Firenze)
Dysfunctional hcn ion channels in idiopathic epilepsy
Di Francesco Jacopo C. (Milano)
The hyperpolarization-activated current as a determinant of
selective nigrostriatal degeneration in parkinson’s desease
Masi Alessio (Firenze)
Contribution of the h-current to autorhythmic activity in
dopaminergic neurones of substantia nigra and olfactory bulb
Pignatelli Angela (Ferrara)
Hyperpolarization-activated cyclic nucleotide gated channels as a
promising new target for pain
Resta Francesco (Firenze)
Free oral communications session 7
11:20-11:40 Break
11:40-13:00 Symposium 25
EPIGENETIC MECHANISM IN BRAIN DISORDERS
Chairs: Battaglioli Elena (Milano) & Pizzorusso Tommaso (Firenze)
Strategies to enhance the cell response to proteotoxicity in
amyotrophic lateral sclerosis (als)
Crippa Valeria (Pavia)
Expression and dendritic trafficking of bdnf-6 splice variant
are impaired in knock-in mice carrying human bdnf val66met
polymorphism
Mallei Alessandra (Milano)
Role of epigenetic mechanisms in experience-dependent
regulation of visual cortical development
Pizzorusso Tommaso (Firenze)
LSD1/KDM1A modulates stress-evoked transcription of
immediate early genes and emotional behavior
Rusconi Francesco (Milano)
Cagliari October • 8th - 11th •2015
17
Sunday 11 October 2015
Symposium 26
PRION AND PRION-LIKE MEACHANIMS IN
NEURODEGENERATIVE DISORDERS. A MOLECULAR
AND CELLULAR VIEW ON NEURODEGENERATION
Chair: Legname Giuseppe (Trieste)
Importance of TDP-43 n-terminal region in aggregation
Buratti Emanuele (Trieste)
Alpha-synuclein amyloid interaction with prion protein: a putative
overlap of two neurodegenerative diseases
Legname Giuseppe (Trieste)
Aß strains and phenotypic heterogeneity of Alzheimer’s disease
Di Fede Giuseppe (Milano)
Role of tunneling nanotubes (tnts) in intercellular spreading of
prions and other protein assemblies involved in neurodegenerative
diseases
Zurzolo Chiara (Parigi - France)
Symposium 27
ACETYLCHOLINE IN THE BASAL GANGLIA
Chair: Mercuri Nicola Biagio (Roma)
Abused drugs regulate dopamine da release in the striatum
throughout presynaptic nicotinic receptors
Mercuri Nicola Biagio (Roma)
Role of muscarinic M1 receptors in DYT1 dystonia
Pisani Antonio (Roma)
The functional cross-talk between nicotinic and glutamatergic
receptors on dopaminergic nerve terminls in the rat nucleus
accumbens
Pittaluga Anna (Genova)
Translational control of muscarinic receptors by an internal
ribosomal entry site (IRES) regulates receptor oligomerization
Scarselli Marco
Free oral communications session 8
18
XVI CONGRESS of the Italian Society for Neuroscience
Sunday 11 October 2015
13:00 Closing remarks
13:30-15:30 Sandwich lunch
14:30-17:00 WORKSHOP on “Professional skills” for under 40
Led by Marina Bentivoglio (University of Verona) and Marina Pizzi (University of Brescia)
Cagliari October • 8th - 11th •2015
19
20
XVI CONGRESS of the Italian Society for Neuroscience