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Local Organizing Committee
Chair
Micaela Morelli
Members
Cristina Cadoni
Anna Carta
Marco Diana
Liana Fattore
Miriam Melis
Annalisa Pinna
Nicola Simola
Valentina Valentini
Scientific Committee
Flavio Moroni
Fiorenzo Conti
Enrico Cherubini
Renato Bernardini
Fabio Blandini
Andrea De Bartolomeis
Yuri Bozzi
Paolo Francesco Fabene
Liana Fattore
Maria Concetta Morrone
Felicita Pedata
Patrizia Popoli
Antonella Scorziello
2
XVI CONGRESS of the Italian Society for Neuroscience
PATRONAGE & SPONSOR
EXHIBITORS
Cagliari October 8 -11 •2015
3
SCIENTIFIC
PROGRAM
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Thursday 8 October 2015
16:30-17:50 Symposium 1
THE DRUNKEN SYNAPSE: FROM MOLECULAR AND
FUNCTIONAL ADAPTATIONS TO CLINICAL PRACTICE
Chairs: Biggio Giovanni (Cagliari), Romualdi Patrizia (Bologna)
Neuroadaptive mechanisms in ethanol withdrawal: from spines to
spikes
Diana Marco (Sassari)
GABA Mechanisms in alcohol-induced effects and neuroplasticity
Korpi Esa R. (Helsinki - Finland)
Increased alcohol consumption and synaptic plasticity in mouse
models of early-life stress
Sanna Enrico (Cagliari)
Role of the opioid system in alcohol addiction: recent evidence
Romualdi Patrizia (Bologna)
GABAergic medication in the treatment of alcohol use disorders: role
of sodium oxybate and baclofen
Addolorato Giovanni (Roma)
Symposium 2
Chairs: De Montis Maria Graziella (Siena), Pistis Marco (Cagliari)
NEURAL ENCODING FOR AVERSION, STRESS AND
NEGATIVE STATES: ADVANCES IN NEUROPHYSIOLOGY AND
NEUROPHARMACOLOGY
PPAR-ALPHA: a potential new therapeutic target for mood disorders
De Montis Maria Graziella (Siena)
Cellular mechanisms in the lateral habenula coding aversive states
Mameli Manuel (Paris - France)
The neural circuit for aversion in cannabinoid withdrawal
Muntoni Anna Lisa (Cagliari)
Early life stress and risk for psychopathology: a role for epigenetics
Riva Marco Andrea (Milano)
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Thursday 8 October 2015
Symposium 3
PARKINSON’S DISEASE: A SPREADING PATHOLOGY?
Chairs: Spano PierFranco (Brescia), Spillantini Maria Grazia (Cambridge - UK)
Prion-like properties of c-terminally truncated alpha-synuclein
Bellucci Arianna (Brescia)
Lysines, Achilles’ heel in alpha-synuclein conversion to a neuronal
oligomeric endotoxin
Bubacco Luigi (Padova)
Putting a brake on aging to counteract Parkinson’s disease
Decressac Mickael (Pozzuoli)
C-rel deficient mice, a mouse model of “spreading” PD-like pathology
Parrella Edoardo (Brescia)
Truncated human alpha-synuclein expression results in synaptic
dysfunction and dopaminergic cell death
Spillantini Maria Grazia (Cambridge - UK)
18:00-19:00 Opening of the Congress
Lecture 1
Huntington:
the story of an ancient gene in search of a
better future
Cattaneo Elena (Milano)
Host: Conti Fiorenzo
19:00-20:30 Welcome Cocktail
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Friday 9 October 2015
09:00-09:45 Lecture 2
How we see and hear stuff: visual and auditory routes to
understanding the material properties of objects
Goodale Melvyn A. (London - Canada)
Host: Morrone Concetta
10:00-11:20 Symposium 4
INNOVATIVE STRATEGIES FOR RESCUING TISSUE INJURY
INDUCED BY STROKE (UNDER 40)
Chairs: Carulli Daniela (Torino), Pignataro Giuseppe (Napoli)
Drug repurposing for immune modulation in ischemic stroke
Amantea Diana (Cosenza)
Role of trail in focal ischemia
Di Benedetto Giulia (Catania)
Epigenetic drugs to reduce post ischemic brain injury, a new
therapeutic approach targeting acetylation of NF-kappaB and histones
Lanzillotta Annamaria (Brescia)
Ionic homeostasis and endogenous neuroprotection
Pignataro Giuseppe (Napoli)
Symposium 5
EARLY IN LIFE DRUG EXPOSURE: FUNCTIONAL CONSEQUENCES ON BRAIN DEVELOPMENT
Chairs: Frau Roberto (Cagliari), Rubino Tiziana (Busto Arsizio)
Shank3 insufficiency uncovers a role of VTA in ASDs
Bellone Camilla (Lausanne - Switzerland)
Short-term abstinence from developmental exposure to cocaine
alters the glutamate synapse following acute stress: implication of
glucocorticoid receptor
Fumagalli Fabio (Milano)
Prenatal exposure to cannabinoids affects postnatal synaptic
properties and plasticity of excitatory transmission on dopamine
neurons of the ventral tegmental area
Melis Miriam (Cagliari)
The impact of adolescent cannabinoid exposure on brain maturation:
focus on epigenetic mechanisms
Rubino Tiziana (Busto Arsizio)
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Symposium 6
ROLE OF GLIAL CELLS IN THE CENTRAL MECHANISM
OF CHRONIC PAIN
FP7 (N. 603191- PAINCAGE PROJECT) SPONSORED SYMPOSIUM Chairs: Marinelli Silvia (Roma), Nykjaer Anders (Aarhus - Denmark)
NGF and glial cells: an overlooked story
Capsoni Simona (Pisa)
TRPV1 channels in the brain: modulation of microglia to neuron
communication in naive and neuropathic mice
Marinelli Silvia (Roma)
Sortilin – A new target for treatment of neuropathic pain?
Nykjaer Anders (Aarhus - Denmark)
Free oral communications session 1
SENSORY SYSTEMS AND SENSORIMOTOR
PROCESSING
Chairs: Caleo Matteo (Pisa), Poggi Lucia (Heidelberg - Germany)
Short-term monocular deprivation alters GABA in the adult human
visual cortex
Lunghi Claudia (Pisa)
Light-induced neurodegeneration, an innovative approach to model
Parkinson’s disease
Maggio Roberto (L’Aquila)
PS-1 protein and free L-Arg enhance the PROP bitter taste
responsiveness by acting as “salivary carriers”
Melis Melania (Cagliari)
A polymeric neural-interface restores light sensitivity and visual acuity
in adult blind Royal College of Surgeons rats
Maya-Vetencourt José Fernando (Genova)
Repeated 6-Hz Corneal Stimulation Progressively Increases
FosB/ΔFosB Levels in the Lateral Amygdala and Induces Seizure
Generalization to the Hippocampus
Giordano Carmela (Modena)
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11:20-11:40 Break
11:40-13:00 Symposium 7
BOOSTING CELL REPAIR IN NEURODEGENERATIVE
DISEASES: MOLECULAR AND CELLULAR
MECHANISMS AND TARGETING STRATEGIES
Chairs: Marchetti Bianca (Catania), Harvey Kirsten (London - UK)
Implications of familial mutations for the pathogenesis and
treatment of neurodegenerative diseases
Harvey Kirsten (London - UK)
Stem cell-based modulation of innate and adaptive immune
responses in CNS plasticity upon injuries
Peruzzotti Luca (Cambridge - UK)
Neuroinflammatory cytokines and their receptors as innovative
targets: restraint of neuronal damage and restoration of function
in AD
Cantarella Giuseppina (Catania)
Targeting Wnt signaling for dopaminergic (DA) neurorepair in PD:
tripartite dialogue between DA neuroprogenitors, glial cells and
the injured DA neurons
Marchetti Bianca (Catania/Troina)
Symposium 8
PHYSIOLOGY AND PHYSIOPATHOLOGY OF
BDNF: TOWARDS THE DEVELOPMENT OF NEW
THERAPEUTIC STRATEGIES FOR MAJOR NEUROPSYCHIATRIC DISEASES
Chairs: Baj Gabriele (Trieste), Popoli Maurizio (Milano)
The “spatial and quantitative code” of BDNF variants: a
therapeutic target for the disorders of the nervous system
Baj Gabriele (Trieste)
Silencing BDNF expression with herpes simplex virus type-1
based amplicon vectors in an experimental model of temporal
lobe epilepsy
Falcicchia Chiara (Ferrara)
Arc expression is modulated post-transcriptionally by splicing of
its 3’utr and BDNF signalling
Giorgi Corinna (Roma)
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Environment-induced neuroplasticity changes in knock-in mice with the
human BDNF val66met polymorphism
Ieraci Alessandro (Milano)
Essential role of astroglial p75 ntr for LTP maintenance and visual
recognition memory
Vignoli Beatrice (Roma)
Symposium 9
CHANGES IN NEUROACTIVE STEROID LEVELS MAY
INDUCE BENEFICIAL AND DETRIMENTAL EFFECTS IN THE
NERVOUS SYSTEM
Chairs: Melcangi Roberto Cosimo (Milano), Riva Marco Andrea (Milano)
Targeting neurosteroid pathways for the treatment of Tourette
syndrome and impulse control disorders: from bench to bedside
Bortolato Marco (Lawrence - USA)
Neonatal neuroactive steroid levels alteration: long term-effects on
behaviour in rats
Darbra Sonia (Barcelona - Spain)
Effect of finasteride treatment in the nervous system: clinical and
experimental observations
Melcangi Roberto Cosimo (Milano)
Neurosteroids during development: implications for GABA-A receptor
function and stress sensitivity in adulthood
Porcu Patrizia (Cagliari)
NEURODEGENERATIVE DISEASES
Chairs: Simola Nicola (Cagliari), Spillantini Maria Grazia (Cambridge - UK)
Drug development strategy for neurodegenerative diseases
Mandel Silvia (Netanya - Israel)
RNA-therapeutics of gene haploinsufficiences
Fimiani Cristina (Trieste)
A longitudinal diffusion kurtosis imaging in transgenic mouse model of
Parkinson’s disease overexpressing alpha synuclein
Khairnar Amit (Brno - Czech Republic)
Silencing of upregulated KV3.4 potassium channels reduces astrocytes
activation, SS-amyloid level in Tg2576 mice
Ciccone Roselia (Napoli)
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Ambroxol-induced rescue of defective glucocerebrosidase is
associated with increased LIMP-2 and saposin C levels in GBA1
mutant Parkinson’s disease cells
Ambrosi Giulia (Pavia)
13:00-14:00 Lunch
14:00-16:00 Poster Session 1
16:00-16:45 Lecture 3
Dopamine and synaptic plasticity: from motor to
cognitive dysfunctions
Calabresi Paolo (Perugia)
Host: Blandini Fabio
17:00-18:20 Symposium 10
INTRINSIC AND EXTRINSIC REGULATION OF
OLIGODENDROCYTE PROGENITOR CELL SELFRENEWAL AND DIFFERENTIATION
Chairs: Angulo Maria Cecilia (Paris - France), Boda Enrica (Torino)
Regulation of synaptic connectivity between GABAergic
interneurons and NG2 cells during cortical oligodendrogenesis
Angulo Maria Cecila (Paris - France)
Molecular mechanisms in oligodendroglioma infiltration and
malignancy
Appolloni Irene (Genova)
Balancing self-renewal and differentiation of the oligodendrocyte
progenitor pool: insights into cell intrinsic regulatory mechanisms
Boda Enrica (Torino)
New mechanisms regulating oligodendroglial differentiation: focus
on the GPR17 receptor and related microRNAs
Lecca Davide (Milano)
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Symposium 11
RECENT ADVANCES IN THE UNDERSTANDING OF
L-DOPA-INDUCED DYSKINESIA: FOCUS ON SEROTONIN,
GLUTAMATE AND DOPAMINERGIC TRANSMISSIONS IN
ANIMAL MODELS OF PARKINSON’S DISEASE
Chairs: Carta Manolo (Cagliari), Tonini Raffaella (Genova)
The serotonin system in L-DOPA induced dyskinesia, from rats to
humans
Björklund Anders (Lund - Sweden)
Alteration of NMDA receptor subunits as synaptic trait of
L-DOPA-induced dyskinesia: molecular mechanisms and effect of
eltoprazine treatment
Gardoni Fabrizio (Milano)
Behavioural and electrophysiological characterization of
serotonergic 5-HT1A/1B agonist, eltoprazine, in experimental
L-DOPA-induced dyskinesia
Picconi Barbara (Roma)
mTOR signaling in L-DOPA-induced dyskinesia
Usiello Alessandro (Napoli)
Symposium 12
THE COMPLEXITY OF MOTOR NEURON DISEASES
Chairs: Poletti Angelo (Milano), Bonanno Giambattista (Genova)
Motor neuron-immune system cross-talk in ALS: evidence and
consequences on the disease
Bendotti Caterina (Milano)
Group I metabotropic glutamate receptors and neurotoxicity in
amyotrophic lateral sclerosis
Milanese Marco (Genova)
The involvement of muscle in SBMA and ALS
Pennuto Maria (Trento)
The protein quality control system in motoneuron diseases
Rusmini Paola (Milano)
12
NEW INSIGHTS ON SYNAPTIC PLASTICITY AND
NEURAL CONNECTIVITY
Chairs: Bozzi Yury (Pisa), Scorziello Antonella (Napoli)
DOI modulates striatal plasticity by inducing ERK phosphorylation
in striatum through 5-HT2A/C receptors in prefrontal cortex
Espinoza Stefano (Genova)
Diurnal oscillation of synaptic wiring of orexinergic neurons in mice
Laperchia Claudia (Verona)
+ +
Quantitative analysis of the co-distribution of GLT-1 and Na , K ATPase alpha isoforms in rat cerebral cortex
Melone Marcello (Ancona)
A molecular code of neural connectivity in the piriform cortex
Diodato Assunta (Paris - France)
Ethanol-induced loss of dendritic spines in accumbens medium
spiny neurons. Insights and hints from a computational model
Enrico Paolo (Sassari)
18:20-20:00 Posters session 2 & Wine and cheese
20:00
General Member Assembly
13
Saturday 10 October 2015
09:00-09:45 Lecture 4
Brain connectomics: exploring the connectome and
synaptome
De Felipe Javier (Madrid - Spain)
Host: Fabene Paolo
10:00-11:20 Symposium 13
NEUROTROPHINS IN PHYSIOLOGY AND PATHOLOGY:
NOVEL MOLECULAR AND CELLULAR PERSPECTIVES
(UNDER 40)
Chairs: Cesca Fabrizia (Genova), Ieraci Alessandro (Milano)
Kidins220/ARMS is a functional mediator of neurotrophin
signaling pathways in nervous system development, maturation
and plasticity
Cesca Fabrizia (Genova)
Neurotrophic-priming of glucocorticoid actions
Jeanneteau Freddy (Montpellier - France)
Single molecule imaging and tracking of neurotrophins and their
receptors in living neuronal cells
Marchetti Laura (Pisa)
BICD1 and dynein modulate long-range growth factor signalling
Terenzio Marco (Rehovot - Israel)
Symposium 14
PARKINSON’S DISEASE: FROM NEUROPATHOLOGY TO
PHARMACOLOGICAL AND NON PHARMACOLOGICAL
TREATMENT OF MOTOR COMPLICATIONS
Chairs: Brambilla Riccardo (Milano), Picconi Barbara (Roma)
Dyskinesia and neuroinflammation: evidence from pulsatile versus
continuous L-DOPA delivery
Carta Anna R. (Cagliari)
Approaches to the treatment of L-DOPA induced dyskinesia
based on ras-erk targeting: far from being a simple matter
Fasano Stefania (Milano)
14
Dopamine D3 receptor modulates L-DOPA-induced dyskinesia by
targeting D1 receptor-mediated striatal signaling
Moratalla Rosario (Madrid - Spain)
Loss of coordinated regulation of synaptic plasticity at striatal
projection neurons in the pathophysiology of motor control.
Tonini Raffaella (Genova)
Intensive rehabilitation in the treatment of L-DOPA-induced
dyskinesia
Frazzitta Giuseppe (Gravedona ed Uniti)
Symposium 15
EATING DISORDERS: FROM BENCH TO BEDSIDE AND
RETURN – ISN SPONSORED SYMPOSIUM
Chairs: Passani Beatrice (Firenze), Gaetani Silvana (Roma)
The BclI receptor gene polymorphism (rs41423247) moderates
the association between childhood overweight, psychopathology,
and clinical outcomes in eating disorders patients: a 7 years follow
up study
Ricca Valdo (Firenze)
First evidence for a role of oleoylethanolamide in the regulation of
appetite in humans
Leweke Markus (Mannheim - Germany)
Animal models of eating disorders and obesity or food addiction
Lutz Thomas (Zurigo - Switzerland)
Role of oleoylethanolamide in the “gut-to-brain axis”: possible
implications for the treatment of obesity and eating disorders
Romano Adele (Roma)
Role of the central histaminergic system in the hypophagic,
procognitive and antidepressant-like effects of the endogenous
PPAR-ALPHA ligand oleoylethanolamide
Provensi Gustavo (Firenze)
15
COGNITION AND DEPRESSIVE-LIKE SYMPTOMS:
THE ROLE OF EXPERIENCE, NEUROTRANSMITTERS
AND DRUGS
Chairs: Fattore Liana (Cagliari), Korpi Esa R. (Helsinki - Finland)
Drugs of abuse change norepinephrine transmission in the bed
nucleus of stria terminalis (BNST): a microdialysis study in freely
moving rats
Jadzic Dragana (Serbia/Cagliari)
Noradrenergic regulation of spatial learning and memory in
the rat: effects of selective lesions and repair by transplanted
noradrenergic neuroblasts
Leanza Giampiero (Trieste)
Esculetin attenuates lipopolysaccharide-induced depressive-like
behavior in mice: inhibition of pro-inflammatory cytokines, and upregulation of BDNF level
Sulakhiya Kunjbihari (Guwahati, India)
The outcome of antidepressant treatment on molecular, cellular
and behavioural endophenotypes of depression is affected by the
quality of the living environment
Poggini Silvia (Roma)
Behavioral characterization of dehydroepiandrosterone effects in
rats
Samardzic Janko (Belgrade - Serbia)
11:20-11:40 Break
11:40-13:00 Symposium 16 NOSE AND GUT: OPEN DOORS TO THE BRAIN
Chairs: Bentivoglio Marina (Verona), Zurzolo Chiara (Paris - France)
Gut microbiota and brain: a mutual relationship
Fiorucci Stefano (Perugia)
The nasal cavity as railway of pathogens and toxins to the brain
Kristensson Krister (Stockholm - Sweden)
16
The enteric nervous system and the progression of Parkinson’s
disease: facts and perspectives
Pizzi Marina (Brescia)
The olfactory mucosa in the diagnosis of prion and prion-like
neurodegenerative diseases: facts and perspectives
Zanusso Gianluigi (Verona)
Symposium 17
D-AMINO ACIDS, FROM BRAIN PHYSIOLOGY TO
DISORDERS
Chairs: Sacchi Silvia (Varese), Usiello Alessandro (Napoli)
Critical role of D-serine in synaptic plasticity relevant to cocaine
addiction
D’Ascenzo Marcello (Roma)
D-aspartate-based modulation of NMDA receptor
neurotransmission: preclinical implication
Errico Francesco (Napoli)
Of the importance of space and time in the functions of the
NMDA receptor coagonists in the hippocampus
Mothet Jean Pierre (Marseille - France)
D-serine metabolism in the brain: the role of d-amino acid oxidase
Sacchi Silvia (Varese)
Symposium 18
HDAC INHIBITION IN NEUROPROTECTION: NEW
CHANCE FOR THERAPY
Chair: Formisano Luigi (Napoli)
Dynamic epigenetic regulation of NCX1 expression in brain
ischemia and in ischemic brain preconditioning, by modification
of histone acetylation
Formisano Luigi (Napoli)
Role of PARP and HDACS in hippocampal slice models of
ischemic preconditioning in vitro
Pellegrini-Giampietro Domenico E. (Firenze)
17
HDAC class I inhibitors and their effect in an in vivo model of
Huntington’s disease
Basso Manuela (Trento)
Epigenetic and transcriptional dysfunction in ischemic brain
injury and Huntington’s disease: from mechanisms to therapeutic
candidates
Yildirim Ferah (Berlin - Germany)
BRAIN INJURY, NEUROINFLAMMATION AND PAIN
Chairs: De Simoni Maria Grazia (Milano), Annunziato Lucio (Napoli)
Neurite contact guidance of ubiquitin ligase E3A (UBE3A)-KO
neurons by nano-grooved substrates
Tonazzini Ilaria (Milano)
Alginate-based hydrogels for central nervous system tissue
regeneration
Casarosa Simona (Trento)
Genetic ablation of Homeodomain Interacting Protein Kinase
(HIPK2) selectively induces apoptosis of cerebellar Purkinje cells
and generates an ataxic-like phenotype
Anzilotti Serenella (Napoli)
Microglial microvesicles as therapeutic vector for
neuroinflammation
Casella Giacomo (Milano)
Non-paralytic botulinum molecules for the control of pain
Mangione Antonina Stefania (London - UK)
13:00-14:00 Lunch
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14:00-16:00 Poster Session 3
16:00-16:45 Lecture 5
Immune proteins in brain development and synaptic plasticity
Matteoli Michela (Milano)
Host: Cherubini Enrico
17:00-18:20 Symposium 19
INNOVATIVE STRATEGIES TO FOSTER BRAIN REPAIR
AFTER DAMAGE
Chairs: Caleo Matteo (Pisa), De Simoni Maria Grazia (Milano)
Role of perineuronal nets in CNS plasticity and repair
Carulli Daniela (Torino)
Ischemic and pharmacological pre-conditioning and postconditoning: molecular mechanisms of neuroprotection and
neuroplasticity
Gerace Elisabetta (Firenze)
Robotic rehabilitation and plasticizing treatments for the recovery
of motor function after focal cortical stroke
Lai Stefano (Pisa)
Mesenchymal stromal cell therapy to foster endogenous
reparative mechanisms in the acute injured brain
Zanier Elisa R. (Milano)
19
Symposium 20
EMERGING ROLE OF EXTRACELLULAR VESICLES IN THE BRAIN:
IMPLICATIONS FOR INTERCELLULAR COMMUNICATIONS,
BIOMARKER DEVELOPMENT AND THERAPY
Chairs: Verderio Claudia (Milano), Benussi Luisa (Brescia)
Role of exosomes released by astrocytes overexpressing mutant
SOD1 in disease spreading and motor neuron pathology in
amyotrophic lateral sclerosis
Basso Manuela (Trento)
Extracellular vesicles isolated from bone marrow mesenchymal
stem cells display an anti-inflammatory effect in experimental
models of Alzheimer’s disease
Coco Silvia (Milano)
Diagnostic role of EVs in neurodegenerative and
neuroinflammatory diseases
Furlan Roberto (Milano)
Shuttling of micrornas from glia-to-neurons: modulation of
neuronal gene expression
Prada Ilaria (Milano)
Symposium 21
MECHANISMS OF EMBRYONIC AND ADULT
NEUROGENESIS - GEI (GRUPPO EMBRIOLOGICO
ITALIANO) SPONSORED SYMPOSIUM
Chairs: Tata Ada Maria (Roma), Casarosa Simona (Trento)
Role for PPAR transcription factors in the energetic metabolic
switch occurring during neurogenesis
Cimini Anna Maria (L’Aquila)
COUP-TFI functions in adult neurogenesis
De Marchis Silvia (Torino)
Altered serotonin homeostasis affects development and
maintenance of serotonergic neuronal circuitry
Pasqualetti Massimo (Pisa)
20
Ascidians as a simple model for the study of development and
evolution of vertebrate nervous system
Pennati Roberta (Milano)
Orchestrating cell fate decisions in progenitor cells of the
embryonic retina
Poggi Lucia (Heidelberg - Germany)
ASTROGENESIS, NEURAL CONNECTIVITY AND
TOXICITY
Chairs: Fabene Paolo (Verona), Angulo Maria Cecilia (Paris - France)
EMX2 role in corticocerebral astrogenesis and glioblastoma
tumors
Falcone Carmen (Trieste)
The cross-talk within Theta rhythms between secondary auditory
cortex and basolateral amygdala is essential during remote fear
memory recall
Cambiaghi Marco (Torino)
In vitro glutamate treatments modify AMPA RNA editing and
ADARs activity
Filippini Alice (Brescia)
Deletion of LRRK2 protects mice from early cognitive
impairments induced by alpha-synuclein fibril inoculation
Volta Mattia (Bolzano)
Long-lasting effects of adolescent MDMA and caffeine exposure
on mesolimbic dopamine transmission, cognitive functions and
dopaminergic neurotoxicity in rats
Cadoni Cristina (Cagliari)
18:20-20:00 Posters session 4 & Wine and cheese
21:00 Congress dinner at Convento San Giuseppe in Cagliari
(reservation is requested)
21
Sunday 11 October 2015
09:00-09:45 Lecture 6
Dopamine and reward: the never ending story
Di Chiara Gaetano (Cagliari)
Host: Moroni Flavio
10:00-11:20 Symposium 22
DOPAMINE FUNCTIONS IN NEURODEGENERATION
AND PLASTICITY (UNDER 40)
Chairs: Espinoza Stefano (Genova), Ronzitti Giuseppe (Evry - France)
Role of nicotinic and dopamine D3 receptor crosstalk in the
regulation of dopaminergic neurons plasticity
Bontempi Leonardo (Brescia)
Identification and characterization of new regulators of the
dopamine system in the animal model C. Elegans
Di Schiavi Elia (Napoli)
Pronounced dopaminergic dysregulation in dopamine transporter
knockout rats
Leo Damiana (Genova)
HDAC inhibition reduces dopamine-dependent neurodegeneration
in a mouse model of DAT-deficiency syndrome
Ronzitti Giuseppe (Evry - France)
Symposium 23
NEW TARGETS, TRANSCRIPTIONAL AND
TRANSDUCTIONAL FACTORS AS AN INNOVATIVE
STROKE RESCUING STRATEGY
Chair: Annunziato Lucio (Napoli)
Remyelination in stroke: new targets and new challenges to
implement repair and functional recovery
Abbracchio Maria Pia (Milano)
Targeting transcriptional and transductional mechanisms
controlling Na+/Ca2+ Exchanger (NCX) as new strategy in stroke
intervention
Annunziato Lucio (Napoli)
22
Versatility of the complement system in stroke
De Simoni Maria Grazia (Milano)
Carbonic anhydrase IX and its interactome in hypoxia
Zambrano Nicola (Napoli)
Symposium 24
HCN CHANNELS IN THE PHYSIOLOGY AND
PATHOLOGY OF THE NERVOUS SYSTEM
Chairs: Di Francesco Jacopo C. (Milano), Mannaioni Guido (Firenze)
HCN ion channels and pain
McNaughton Peter (London - UK)
Hyperpolarization-activated cyclic nucleotide gated channels as a
promising new target for pain treatment
Resta Francesco (Firenze)
Contribution of the h-current to autorhythmic activity in
dopaminergic neurons of substantia nigra and olfactory bulb
Pignatelli Angela (Ferrara)
Dysfunctional HCN ion channels in idiopathic epilepsy
Di Francesco Jacopo C. (Milano)
The hyperpolarization-activated current as a determinant of
selective nigrostriatal degeneration in Parkinson’s desease
Masi Alessio (Firenze)
INVOLVEMENT OF NEURODEGENERATIVE
PROCESSES IN NEUROLOGICAL DISEASES
Chairs: Morelli Micaela (Cagliari), Bernardini Renato (Catania)
Effect of curcumins in RNA regulation and in amyloid beta
aggregation in Alzheimer’s disease patients.
Gagliardi Stella (Pavia)
Identification of 3microRNAs of potentially regulating the
expression of GPR17, a receptor involved in the development of
oligodendroglial precursor cells
Marangon Davide (Milano)
23
Exosomes from mesenchymal stem cells: experimental
assessment on in vitro and in vivo models of ALS
Bonafede Roberta (Verona)
Saffron treatment in rat model of retinal dystrophy
Di Paolo Mattia (L’Aquila)
Intracarotid infusion of mesenchymal stem cells in an animal
model of Parkinson’s disease, focusing on cell distribution,
neuroprotective and behavioral effects
Cerri Silvia (Pavia)
11:20-11:40 Break
11:40-13:00 Symposium 25
EPIGENETIC MECHANISM IN BRAIN DISORDERS
Chairs: Battaglioli Elena (Milano), Pizzorusso Tommaso (Firenze)
Strategies to enhance the cell response to proteotoxicity in
amyotrophic lateral sclerosis (ALS)
Crippa Valeria (Pavia)
Expression and dendritic trafficking of BDNF-6 splice variant
are impaired in knock-in mice carrying human BDNF val66met
polymorphism
Mallei Alessandra (Milano)
Experience-dependent DNA methylation regulates plasticity in the
developing visual cortex
Pizzorusso Tommaso (Firenze)
LSD1/KDM1A modulates stress-evoked transcription of
immediate early genes and emotional behavior
Rusconi Francesco (Milano)
24
Symposium 26
PRION AND PRION-LIKE MEACHANIMS IN
NEURODEGENERATIVE DISORDERS. A MOLECULAR
AND CELLULAR VIEW ON NEURODEGENERATION
Chairs: Legname Giuseppe (Trieste), Zanusso Gianluigi (Verona)
Importance of TDP-43 N-terminal region in aggregation
Buratti Emanuele (Trieste)
Alpha-synuclein amyloid interaction with prion protein: a putative
overlap of two neurodegenerative diseases
Legname Giuseppe (Trieste)
Unraveling the molecular basis of phnotypic heterogeneity of
Alzheimer disease: the model of prion strains
Di Fede Giuseppe (Milano)
Role of tunneling nanotubes (TNTS) in intercellular spreading of
prions and other protein assemblies involved in neurodegenerative
diseases
Zurzolo Chiara (Parigi - France)
Symposium 27
ACETYLCHOLINE IN THE BASAL GANGLIA
Chairs: Mercuri Nicola Biagio (Roma), Fratta Walter (Cagliari)
Abused drugs regulate dopamine da release in the striatum
throughout presynaptic nicotinic receptors
Mercuri Nicola Biagio (Roma)
Role of muscarinic M1 receptors in DYT1 dystonia
Pisani Antonio (Roma)
The functional cross-talk between nicotinic and glutamatergic
receptors on dopaminergic nerve terminls in the rat nucleus
accumbens
Pittaluga Anna (Genova)
G protein-coupled receptors oligomers in the basal ganglia:
from single-molecule fluorescence microscopy to therapeutic
perspectives
Scarselli Marco (Pisa)
13:00 Closing remarks
25
13:30-14:30 Sandwich lunch
14:30-17:00 WORKSHOP on “Professional skills” for under 40
Led by Marina Bentivoglio (University of Verona) and Marina Pizzi (University of Brescia)
26
POSTERS
POSTER SESSION 1 e 2
DEVELOPMENT
1/09 - NF-KAPPAB P50 KNOCK-OUT MICE AS ANIMAL MODEL OF
NEURODEVELOPMENTAL DISORDERS
Sara Anna Bonini
Andrea Mastinu, Giuseppina Maccarinelli, Marika Premoli, Giulia FerrariToninelli, Maurizio Memo
2/09 - FROM NGF SIGNALING TO MIR-219-5P: OLIGODENDROCYTES’
DIFFERENTIATION AND MYELINATION
Sabrina Turturro
Rossella Brandi, Ivan Arisi, Raffaella Scardigli, Corinna Giorgi, Andrea
Ennio Storti, Flavia Ricevuti, Federico La Regina, Mara D’Onofrio, Antonino
Cattaneo
3/09 - MULTIGENERATIONAL EFFECTS OF PRENATAL EXPOSURE TO
VALPROIC ACID ON NEURODEVELOPMENT: A PRECLINICAL STUDY
Anna Maria Tartaglione
Laura Ricceri, Benedetta Perrone, Alessia De Felice, Emanuela Balestrieri,
Paola Sinibaldi-Vallebona, Gemma Calamandrei
4/09 - MATERNAL IMMUNE ACTIVATION AFFECTS DOPAMINE NEURON
SPONTANEOUS ACTIVITY IN THE OFFSPRING
Marta De Felice
Sonia Aroni, Anna Lisa Muntoni, Roberto Frau, Alessandra Pardu, Paola
Devoto, Marco Pistis
5/09 - REPEATED MATERNAL SEPARATION IN C57BL/6J MICE: CHANGES IN
HIPPOCAMPAL GABAERGIC AND GLUERGIC SYNAPTIC FUNCTION
AND INCREASED VOLUNTARY ETHANOL CONSUMPTION
Ashish Avinash Gorule
Giuseppe Talani, Valentina Licheri, Giovanni Biggio, Enrico Sanna
6/09 - DIFFERENTIATION AND MIGRATION OF NEURAL STEM CELLS
(NSCS) DURING PRECONDITIONING IN A MOUSE MODEL OF
NEONATAL HYPOXIA ISCHEMIA
Paola Brancaccio
Serenella Anzilotti, Pierpaolo Cerullo, Ornella Cuomo, Gianfranco Di Renzo,
Lucio Annunziato, Giuseppe Pignataro
7/09 - THE CHRNA7 AND ITS DUPLICATED ISOFORM, CHRFAM7A, GENE
REGULATION AND EXPRESSION IN NEURONAL AND IMMUNE CELL
MODEL
Annalisa Maroli
Diego Fornasari, Roberta Benfante
28
8/09 - NURR1 AND LMX1A TRANSCRIPTION FACTORS COOPERATE TO
PROMOTE DOPAMINERGIC DIFFERENTIATION
Floriana Volpicelli
Salvatore Pulcrano, Claudia De Sanctis, Carla Perrone Capano, Umberto
di Porzio, Gian Carlo Bellenchi
9/09 - THE SEROTONIN RECEPTOR 7 STIMULATES NEURITE ELONGATION
THROUGH CDK5, MTOR AND CDC42 PATHWAYS AND MODULATES
DENDRITIC SPINES MORPHOLOGY
Luisa Speranza
Marta Molinari, Floriana Volpicelli, Maria Egle De Stefano, Loredana
Lombardi, Gian Carlo Bellenchi, Umberto di Porzio, Marianna Crispino,
Carla Perrone-Capano
+
2+
10/09 - INVOLVEMENT OF THE NA /CA EXCHANGER ISOFORM 1 (NCX1)
IN NGF-INDUCED NEURONAL DIFFERENTIATION THROUGH CA2+DEPENDENT AKT PHOSPHORYLATION
Rossana Sirabella
Agnese Secondo, Alba Esposito, Francesca Boscia, Anna Pannaccione,
Pasquale Molinaro, Maria Cantile, Roselia Ciccone, Maria Josè Sisalli,
Antonella Scorziello, Gianfranco Di Renzo, Lucio Annunziato
11/09 - INFLAMMATORY RELATED PATHWAYS AND SGK1 SIGNALING AS
TARGETS OF EARLY LIFE STRESSFUL EVENTS: ROLE OF DNA
METHYLATION AND MIRNAS
Giona Plazzotta
Alessia Luoni, Marco Andrea Riva, Carmine Maria Pariante, Annamaria
Cattaneo
12/09 - INVOLVEMENT OF MUSCLE-SPECIFIC MIRNA-206 IN THE SPINAL
MUSCULAR ATROPHY PATHOGENESIS
Marina Boido
Valeria Valsecchi, Elena De Amicis, Antonio Piras, Alessandro Vercelli
13/09 - ORIGIN AND GENERATION OF DIFFERENT ASTROGLIAL
PHENOTYPES IN THE CEREBELLUM
Valentina Cerrato
Elena Parmigiani, Ketty Leto, Elisa Fucà, María Figueres-Oñate, Laura
López Mascaraque, Annalisa Buffo
29
EXCITABILITY, SYNAPTIC TRANSMISSION, NETWORK
FUNCTIONS
14/09 - ACTION OF MEMANTINE ON STRIATAL SYNAPTIC PLASTICITY
Maria Mancini
Veronica Ghiglieri, Vincenza Bagetta, Valentina Pendolino, Anna Vannelli,
Fabrizio Cacace, Desirée Mineo, Paolo Calabresi, Barbara Picconi
15/09 - A NOVEL CAMP/PKA/APP/ASS PATHWAY MODULATES
HIPPOCAMPAL LTP
Claudia Rebosio
Daniela Rivera, Maria Adelaide Pronzato, Daniela Puzzo, Ottavio Arancio,
Roberta Ricciarelli, Ernesto Fedele
16/09 - DIFFERENT MOUSE GENETIC MODELS OF HUMAN DYT1 DYSTONIA
SHARE CHANGES OF PHOSPHODIESTERASE-10A IN BASAL
GANGLIA CIRCUITS
Ilaria Saverioni
Silvia Cardarelli, Vincenza D’Angelo, Valentina Castelli, Mauro Giorgi,
Stefano Biagioni, Francesca Palumbo, Alessandro Martorana, Paola
Bonsi, Antonio Pisani, Giuseppe Sancesario
17/09 - IH SUPPRESSION INCREASES SYNAPTIC EXCITABILITY OF
MIDBRAIN DOPAMINERGIC NEURONS IN VITRO AND CAUSES
SELECTIVE NIGROSTRIATAL DEGENERATION IN VIVO
Carmen Carbone
Alessio Masi, Roberto Narducci, Francesco Resta, Alessia Costa,
Gustavo Provensi, Guido Mannaioni
18/09 - LOCALLY SYNTHESIZED 17BETA-ESTRADIOL MEDIATES SYNAPTIC
LONG-TERM POTENTIATION VIA D1-LIKE DOPAMINE SIGNALING IN
THE DORSAL STRIATUM
Alessandro Tozzi
Antonio de Iure, Michela Tantucci, Valentina Durante, Ana Quiroga-Varela,
Michela Di Mauro, Petra Mazzocchetti, Silvarosa Grassi, Vito Enrico
Pettorossi, Paolo Calabresi
19/09 - FENOFIBRATE, A CLINICALLY USED PPARA AGONIST, ENHANCES
DOPAMINE AND SEROTONIN NEURONAL ACTIVITY
Sonia Aroni
Marta De Felice, Maria Graziella De Montis, Miriam Melis, Marco Pistis
30
20/09 - ELEVATION OF KYNURENIC ACID LEVELS SUPPRESSES
DELTA9-TETRAHYDROCANNABINOL-INDUCED EXCITATION OF
MESOLIMBIC DOPAMINE AND PREFRONTAL CORTEX PYRAMIDAL
NEURONS
Claudia Sagheddu
Miriam Melis, Anna Lisa Muntoni, Marco Pistis
21/09 - EARLY ALTERATION OF HIPPOCAMPAL NEURONAL FIRING
INDUCED BY ABETA42 OLIGOMERS IN ALZHEIMER’S DISEASE
Daniela Gavello
Arianna Allio, Chiara Calorio, Hélène Marie, Emilio Carbone, Andrea
Marcantoni
22/09 - GABAA- AND BENZODIAZEPINE RECEPTOR-MEDIATED INHIBITION
OF HIPPOCAMPAL NEURONAL FIRING INDUCED BY BUD
EXTRACTS FROM TILIA TOMENTOSA MOENCH
Chiara Calorio
Arianna Allio, Claudio Franchino, Emilio Carbone, Andrea Marcantoni
23/09 - LEVETIRACETAM DOWN-REGULATES THE EXPRESSION OF
SEVERAL SYNAPTIC VESICLES PROTEINS IN RAT BRAIN CORTEX
Daniele Marcotulli
Giorgia Fattorini, Luca Bragina, Fiorenzo Conti
24/09 - TDP43 MODULATION BY THE GLUTAMATERGIC SYSTEM
Michele Nutini
Patrizia Longone
25/09 - CHOLINERGIC MODULATION OF MEDIAL SEPTUM AND
HIPPOCAMPAL CA3 OUTPUTS IN VIVO
Marilena Griguoli
Stefano Zucca, Meryl Malezieux, Christophe Mulle
26/09 - ELECTROPHYSIOLOGICAL CHARACTERIZATION OF CALRETININ
INTERNEURONES IN THE MOUSE OLFACTORY BULB
Angela Pignatelli
Alex Fogli Iseppe, Samah Batran, Faride Pighin, Elena Zucchini, Pietro
Scaduto, Ottorino Belluzzi
27/09 - IDENTIFICATION OF DIFFERENT SPLICING VARIANTS OF KV7.4
POTASSIUM CHANNELS IN THE F11 NEURONAL CELL LINE
Alessandro Medoro
Maria Virginia Soldovieri, Iolanda Vinciguerra, Maurizio Taglialatela
31
28/09 - IMMUNOCHEMICAL DETECTION OF BDNF AND TRKB IN THE BRAIN
OF PSYCHOGENETICALLY SELECTED ROMAN HIGH- AND LOWAVOIDANCE RATS
Maria Pina Serra
Laura Poddighe, Marianna Boi, Maria Antonietta Piludu, Osvaldo Giorgi,
Maria Giuseppa Corda, Marina Quartu
29/09 - STUDY OF THE MECHANISMS REGULATING THE LOCALIZATION
OF NA+/CA2+ EXCHANGER 3 IN MITOCHONDRIA AND ITS
PATHOPHYSIOLOGICAL IMPLICATIONS
Stefania Fiorillo
Antonella Scorziello, Pasquale Molinaro, Maria Josè Sisalli, Lucio
Annunziato
30/09 - BIOCHEMICAL, MORPHOLOGICAL, AND PHARMACOLOGICAL
EVIDENCE FOR KV7.4 CHANNELS EXPRESSION IN NEURONAL
MITOCHONDRIA
Laura Manocchio
Iolanda Vinciguerra, Maria Virgina Soldovieri, Gianluca Paventi, Paolo
Ambrosino, Vincenzo Calderone, Salvatore Passarella, Maurizio
Taglialatela
31/09 - BEHAVIORAL AND ELECTROPHYSIOLOGICAL ASPECTS OF
NEOCORTICAL CB1 SPECIFIC KO MICE REVEAL A MURINE MODEL
OF NEUROPATHIC PAIN
Maria Cristina Marrone
Michela Giustizieri, Giovanni Marsicano, Silvia Marinelli
32/09 - ALPHA-SYNUCLEIN IMPAIRS LONG-TERM POTENTIATION
OF SYNAPTIC TRANSMISSION OF STRIATAL CHOLINERGIC
INTERNEURONS TARGETING THE GLUN2D-EXPRESSING NMDA
RECEPTOR
Antonio de Iure
Alessandro Tozzi, Valentina Durante, Ana Quiroga-Varela, Michela
Tantucci, Petra Mazzocchetti, Massimiliano Di Filippo, Cinzia Costa,
Cristiano Spaccatini, Fabrizio Gardoni, Omar El-Agnaf, Calabresi Paolo
33/09 - TM4SF2 KNOCKOUT MICE DISPLAY SYNAPTIC DYSFUNCTIONS
AND DEFICITS IN ASSOCIATIVE MEMORY
Luca Murru
Alessandra Folci, Elena Vezzoli, Edoardo Moretto, Silvia Bassani, Anna
Longatti, Veronica Bianchi, Patrizia D’adamo, Maura Francolini, Maria
Passafaro
32
34/09 - ALPHA-SYNUCLEIN PRODUCES NMDA-MEDIATED STRIATAL
SYNAPTIC DYSFUNCTION
Valentina Durante
Alessandro Tozzi, Antonio de Iure, Ana Quiroga-Varela, Michela Tantucci,
Petra Mazzocchetti, Cristiano Spaccatini, Massimiliano Di Filippo, Cinzia
Costa, Omar El-Agnaf, Paolo Calabresi
35/09 - TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING
LIGAND (TRAIL) ATTENUATES THE EXPRESSION OF THE NA+/CA2+
EXCHANGER (NCX3) IN DIFFERENTIATED SH-SY5Y NEURONAL CELLS
Oriana Valerio
Giulia Di Benedetto, Vincenzo Lariccia, Renato Bernardini, Salvatore
Amoroso, Giuseppina Cantarella
36/09 - AGOMELATINE TREATMENT INDUCES SPECIFIC AND TIMEDEPENDENT MODULATION OF RAT HIPPOCAMPAL MIRNAS AND
RELATED TARGET GENES
Mara Seguini
Daniela Tardito, Veronica Rota, Ivan Merelli, Dario Corrada, Luciano
Milanesi, Giorgio Racagni, Maurizio Popoli
37/09 - ROLE OF ATP P2Y1 RECEPTOR IN THE RAT DENTATE GYRUS
AFTER A SEVERE ISCHEMIC INSULT
Irene Fusco
Elisabetta Coppi, Giovanna Maraula, Daniele Lana, Maria Grazia
Giovannini, Tommaso Mello, Andrea Galli, Felicita Pedata, Anna Maria
Pugliese
38/09 - ETHANOL MODULATES HYPERPOLARIZATION-ACTIVATED CATION
CURRENTS (IH) IN RAT HIPPOCAMPAL CA3 PYRAMIDAL NEURONS:
INVOLVEMENT OF THE AC/CAMP/PKA INTRACELLULAR PATHWAY
Valentina Licheri
Giuseppe Talani, Giovanni Biggio, Enrico Sanna
39/09 - FOOD RESTRICTION IN RATS IS ASSOCIATED WITH AN ENHANCED
GLUTAMATERGIC SYNAPTIC PLASTICITY IN THE HIPPOCAMPAL
CA1 FIELD: INVOLVEMENT OF CB1 RECEPTORS
Giuseppe Talani
Valentina Licheri, Francesca Biggio, Valentina Locci, Maria Cristina
Mostallino, Laura Cocco, Laura Firino, Giacomo Sitzia, Giovanni Biggio,
Enrico Sanna
40/09 - EFFECT OF PSYCHOSTIMULANT DESIGNER DRUGS ON BRAIN
NEUROTRANSMITTERS
Katarzyna Kaminska
Karolina Noworyta-Sokolowska, Alexandra Jurczak, Anna Górska,
Krystyna Golembiowska
33
41/09 - EFFECT OF SUB-CHRONIC ADMINISTRATION OF MDMA AND
CAFFEINE ON MONOAMINE TRANSMITTERS AND PRODYNORPHIN
GENE IN THE MOUSE BRAIN
Anna Maria Górska
Katarzyna Kaminska, Agnieszka Wawrzczak-Bargiela, Ryszard
Przewlocki, Krystyna Golembiowska
42/09 - SYSTEMIC AND LOCAL EFFECTS OF ANTIDEPRESSANTS AND
KETAMINE ON CATECHOLAMINE TRANSMISSION IN THE BED
NUCLEUS OF STRIA TERMINALIS: A MICRODIALYSIS STUDY IN
FREELY MOVING RATS
Roberto Cadeddu
Dragana Jadzic, Ezio Carboni
43/09 - FUNCTIONALIZED POLYMERIC NANOPARTICLES AS KEY TO OPEN
BRAIN DOORS
Corinne Portioli
Michele Bovi, Marta Donini, Donatella Benati, Massimiliano Perduca,
Stefano Dusi, Hugo Monaco, Marina Bentivoglio
44/09 - GAD67 IMMUNOREACTIVITY IN THE CENTRAL AMYGDALA AS A
MARKER OF LONG-LASTING CHANGES IN NEURONAL ACTIVITY
CAUSED BY ADOLESCENT PRE-EXPOSURE TO DRUGS OF ABUSE
Annesha Sil
Augusta Pisanu, Daniele Lecca, Andrea Scifo, Cristina Cadoni, Gaetano
Di Chiara
45/09 - IMMUNOCHEMICAL LOCALIZATION OF GABAA RECEPTOR
SUBUNITS IN THE FRESHWATER POLYP HYDRA VULGARIS
(CNIDARIA, HYDROZOA)
Andrea Locci
Roberta Imperatore, Francesca Santoru, Patrizia Porcu, Luigia Cristino,
Paola Pierobon, Alessandra Concas
46/09 - SELECTIVE ACTIVATION OF PARVALBUMIN- OR SOMATOSTATINEXPRESSING INTERNEURONS TRIGGERS EPILEPTIC SEIZURELIKE
ACTIVITY IN MOUSE MEDIAL ENTORHINAL CORTEX
Latefa Yekhlef
Gianluca Breschi, Laura Lagostena, Giovanni Russo, Stefano Taverna
47/09 - FOXG1 ANTAGONIZES CORTICO-CEREBRAL ASTROGENESIS
Clara Grudina
Carmen Falcone, Nika Blecich, Manuela Santo, Antonello Mallamaci
34
SLEEP, AUTONOMIC AND NEUROENDOCRINE SYSTEMS
48/09 - METABOLIC FATE AND EFFLUX OF CHOLESTEROL IN THE
HIPPOCAMPUS OF DIABETIC MALE RAT
Simone Romano
Silvia Giatti, Marzia Pesaresi, Nico Mitro, Gaia Cermenati, Donatella
Caruso, Roberto Cosimo Melcangi
49/09 - EFFECTS OF LEPTIN ON MOUSE CHROMAFFIN CELLS FIRING AND
CATHECOLAMINES SECRETION
Daniela Gavello
David Vandael, Sara Gosso, Emilio Carbone, Valentina Carabelli
50/09 - T-TYPE CALCIUM CHANNELS IN MOUSE CHROMAFFIN CELLS:
CHARACTERIZATION AND SENSITIVITY TO STRESSFUL STIMULI
Chiara Calorio
Andrea Marcantoni, Emilio Carbone
51/09 - AN INTEGRATED APPROACH FOR MORPHOFUNCTIONAL ANALYSIS
OF DRGS IN NORMAL AND DIABETIC MICE
Elisa Ciglieri
Francesco Ferrini, Simone Tonti, Santa Di Cataldo, Elisa Ficarra, Chiara
Salio
52/09 - TARGETING SUBSTANTIA NIGRA THROUGH OXYTOCIN
RECEPTORS
Laura Angioni
Cristina Cocco, Antonio Argiolas, Gian Luca Ferri, Maria Rosaria Melis,
Fabrizio Sanna
53/09 - EFFECTS OF PRENATAL STRESS EXPOSURE AND MATERNAL
SEPARATION ON HPA AXIS RESPONSIVENESS AND BEHAVIOR IN
YOUNG ADULT MALE RATS
Francesca Biggio
Valentina Locci, Giorgia Boero, Maria Giuseppina Pisu, Pierluigi Olla,
Mariangela Serra
54/09 - SOCIAL ISOLATION INDUCES A DISREGULATION OF HPA AXIS
ACTIVITY IN MALE RATS
Maria Giuseppina Pisu
Giorgia Boero, Pierluigi Olla, Francesca Biggio, Mariangela Serra
55/09 - ALTERED MATERNAL STYLE IN A MOUSE MODEL OF IDIOPATHIC
AUTISM: A ROLE FOR OXYTOCIN?
Maria Carla Giorgi
Debora Cutuli, Alessia De Felice, Stefano Farioli Vecchioli, Gemma
Calamandrei
35
56/09 - CXCL-10 AND SLEEP CHANGES AS BRAIN DISEASE BIOMARKERS
IN EXPERIMENTAL SLEEPING SICKNESS
Chiara Tesoriero
Claudia Laperchia, Valeria Colavito, Valentina La Verde, Gigliola GrassiZucconi, Jean Rogers, Peter GE Kennedy, Paul Montague, Marina
Bentivoglio
COGNITION AND BEHAVIOUR
57/09 - REPEATED CYCLES OF CHRONIC INTERMITTENT ETHANOL
EXPOSURE ALTER GABAA RECEPTOR GENE EXPRESSION
Paolo Follesa
Gabriele Floris, Gino Paolo Asuni, Beniamina Mercante, Franca Deriu
58/09 - VOLUNTARY ETHANOL DRINKING IN GABAB KNOCK-OUT MICE:
EFFECT OF GAMMA-HYDROXYBUTYRIC ACID
Paolo Follesa
Gabriele Floris, Gino Paolo Asuni, Beniamina Mercante, Franca Deriu
59/09 - EFFECT OF ACUTE AND CHRONIC ADMINISTRATION OF
METHOXETAMINE ON BEHAVIOUR, MOOD AND REWARD
Mary Tresa Zanda
Silvia Antinori, Francesco Ciaccio, Anna Mutti, Laura Mancini, Laura
Padovani, Maria Scherma, Sonia Aroni, Anna Lisa Muntoni, Walter Fratta,
Paola Fadda, Cristiano Chiamulera, Liana Fattore
60/09 - BEHAVIOURAL PHENOTYPING OF CONDITIONAL CEREBELLAR
SPECIFIC CHD7- DEFICIENT MICE
Angela Caruso
Kimberley Riegman, Caterina Michetti, Mara Sabbioni, Albert Basson,
Cathy Fernandes, Maria Luisa Scattoni
61/09 - INTERACTION BETWEEN EARLY PSYCHOSOCIAL STRESS AND
MAO-A ON PATHOLOGICAL AGGRESSION
Alessandra Pardu
Roberto Frau, Romina Pes, Silvia Fanni, Pierluigi Saba, Sean Godar,
Simona Scheggi, Maria Graziella Demontis, Marco Bortolato, Paola
Devoto
36
62/09 - INVOLVEMENT OF GLUTAMATE NMDA RECEPTORS IN THE ACUTE,
LONG-TERM, AND CONDITIONED EFFECTS OF AMPHETAMINE ON
RAT 50-KHZ ULTRASONIC VOCALIZATIONS
Nicola Simola
Giulia Costa, Micaela Morelli
63/09 - ROMAN HIGH- AND LOW-AVOIDANCE RATS DIFFER IN THE
EXPRESSION OF PERK IN THE CEREBRAL CORTEX AND
AMYGDALA DURING AVOIDANCE LEARNING
Maria Antonietta Piludu
Michela Rosas, Marta Sabariego, Valentina Giugliano, Osvaldo Giorgi, Elio
Acquas, Maria Giuseppa Corda
64/09 - POSSIBLE ROLE OF DOPAMINE IN THE DIFFERENCES IN SEXUAL
BEHAVIOUR BETWEEN ROMAN HIGH AND LOW AVOIDANCE
RATS: BEHAVIORAL, PHARMACOLOGICAL AND NEUROCHEMICAL
FINDINGS
Fabrizio Sanna
Maria Antonietta Piludu, Maria Giuseppa Corda, Maria Rosaria Melis,
Osvaldo Giorgi, Antonio Argiolas
65/09 - SPATIAL LEARNING IN INDIVIDUALS UNDERGOING ALCOHOL
DETOXIFICATION
Valentina Carito
Giovanna Coriale, Marco Fiore, Mauro Ceccanti
66/09 - MATERNAL IMMUNE ACTIVATION IN MICE: SHORT AND LONG
TERM NEUROBEHAVIOURAL EFFECTS IN OFFSPRING
Daniele Vigli
Maria Luisa Scattoni, Gianmauro Palombelli, Rossella Canese, Laura
Ricceri
67/09 - ADOLESCENCE VERSUS ADULTHOOD: DIFFERENTIAL EFFECTS OF
DRUGS OF ABUSE ON MESOLIMBIC DOPAMINE TRANSMISSION
Silvia Corongiu
Christian Dessì, Cristina Cadoni
68/09 - CHANGES IN GLUTAMATE RELEASE AND RELATED MOLECULAR
MECHANISMS INDUCED BY CHRONIC MILD STRESS IN
VULNERABLE AND RESILIENT RATS. MODULATION BY KETAMINE
Paolo Tornese
Laura Musazzi, Nathalie Sala, Francesco Brizzi, Giorgio Racagni, Maurizio
Popoli
37
69/09 - TIME-DEPENDENT FUNCTIONAL, STRUCTURAL, AND BEHAVIORAL
CHANGES INDUCED BY ACUTE STRESS IN RATS. LOOKING FOR
NEW TARGETS FOR NEUROPSYCHIATRIC THERAPIES
Nathalie Sala
Laura Musazzi, Paolo Tornese, Nicoletta Nava, Giulia Treccani, Chiara
Bazzini, Francesca Sala, Roberta Luciano, Giorgio Racagni, Jens Randel
Nyengaard, Gregers Wegener, Maurizio Popoli
70/09 - EFFECTS OF 25I-NBOME, A NEW POTENT 5HT2A AGONIST, ON THE
CENTRAL NERVOUS SYSTEM OF RODENTS
Cristina Miliano
Andrea Ossato, Matteo Marti, Barbara Loi, Giovanna Mulas, Anna Carta,
Gaetano Di Chiara, Maria Antonietta De Luca
71/09 - EFFECTS OF WITHANIA SOMNIFERA DUNAL ON ETHANOL- AND
MORPHINE-ELICITED CONDITIONED PLACE PREFERENCE IN MICE
Michela Rosas
Simona Porru, Liliana Spina, Rosanna Longoni, Sanjay Kasture, Stefania
Ruiu, Alessandro Orrù, Alessandra Peana, Elio Acquas
72/09 - EFFECTS OF WITHANIA SOMNIFERA DUNAL ON ETHANOL SELFADMINISTRATION IN RATS
Elio Acquas
Michela Rosas, Simona Porru, Liliana Spina, Sanjay Kasture, Alessandra
Peana
73/09 - ROLE OF PHOSPHORYLATED ERK IN THE MOTIVATIONAL
PROPERTIES OF ETHANOL AS DETERMINED BY CONDITIONED
PLACE PREFERENCE AND CONDITIONED PLACE AVERSION
Liliana Spina
Michela Rosas, Simona Porru, Rosanna Longoni, Alessandra Peana, Elio
Acquas
74/09 - EFFECT OF L-DOPA ON COCAINE-TAKING AND COCAINE-SEEKING
BEHAVIOR IN RATS
Silvia Antinori
Liana Fattore, Pierluigi Saba, Walter Fratta, Gian Luigi Gessa, Paola
Devoto
38
SENSORY AND MOTOR SYSTEM
75/09 - EFFECT OF 5-ALPHA REDUCTASE INHIBITION IN L-DOPA-INDUCED
DYSKINESIA
Silvia Fanni
Roberto Frau, Elisabetta Tronci, Camino Fidalgo, Carlo Lisci, Alessandra
Pardu, Romina Pes, Pierluigi Saba, Paola Devoto, Marco Bortolato,
Manolo Carta
76/09 - NEUROCHEMICAL MECHANISMS INVOLVED IN MDMA-INDUCED
NEUROTOXICITY IN MICE
Giulia Costa
Nicola Simola, Micaela Morelli
77/09 - CHRONIC HYPOXIA UP-REGULATES CAV3.2 T-TYPE CALCIUM
CHANNELS IN RAT SENSORY NEURONS
Chiara Calorio
Andrea Marcantoni, Valentina Comunanza, Federico Bussolino, Emilio
Carbone
78/09 - UMAN RECOMBINANT NGF EYE DROPS IN OPTIC NERVE CRUSH
MODEL: MODULATORY AND REPARATIVE EFFECTS IN THE RETINA
AND VISUAL BRAIN AREAS
Sara De Nicolò
Pamela Rosso, Louise Mesentier-Louro, Alessandro Lambiase, Paolo
Rama, Paola Tirassa
79/09 - VISUAL PROCESSING IN A MOUSE MODEL OF FOCAL
NEOCORTICAL EPILEPSY
Matteo Caleo
Eleonora Vannini, Alessandro Panarese, Alberto Mazzoni, Marta
Pietrasanta, Stefano Lai, Silvestro Micera, Laura Restani
80/09 - L
-DOPA CHRONIC TREATMENT INCREASES REACTIVE MICROGLIA
AND TNF- ALPHA PRODUCTION IN THE 6-OHDA LESIONED
STRIATUM
Giovanna Mulas
Elisabetta Pillai, Elena Espa, Sandro Fenu, Daniela Lecca, Saturnino
Spiga, Anna Rosa Carta
39
81/09 - TRANSACCADIC SPATIAL STABILITY AND PRE-SACCADIC
PERCEPTION
Paola Binda
Guido Marco Cicchini, David Burr, Maria Concetta Morrone
82/09 - VISUAL BOLD RESPONSE IN LATE-BLIND SUBJECTS WITH ARGUS
II RETINAL PROSTHESIS
Elisa Castaldi
Marco Cicchini, Laura Cinelli, Laura Biagi, Michela Tosetti, Stanislao
Rizzo, Concetta Morrone
83/09 - EXPERIENCE-DEPENDENT DNA METHYLATION REGULATES
PLASTICITY IN THE DEVELOPING VISUAL CORTEX
Tommaso Pizzorusso
Debora Napoli, Paola Tognini, Jonida Tola, Davide Silingardi, Della
ragione Floriana, Maurizio D’Esposito
DISORDERS OF THE NERVOUS SYSTEM
1/10 - F
US PROTEIN IS MISLOCALIZED IN THE CYTOPLASM OF
CULTURED SKIN FIBROBLASTS FROM PRECLINICAL FUS P525L
MUTATION CARRIERS
Margherita Lo Bello
Francesca Di Fini, Francesca L Conforti, Vincenzo La Bella, Rossella
Spataro
2/10 - C
ATESTATIN AND MUSCIMOL INTERACTION IN AMYGDALA AND
BRAINSTEM OF SPONTANEOUSLY HYPERTENSIVE RATS EXERT
ANTIHYPERTENSIVE AND NEUROPROTECTIVE EFFECTS
Ennio Avolio
Sushil K Mahata, Maria Mele, Raffaella Alò, Gilda Fazzari, Teresa Pasqua,
Tommaso Angelone, Maria Carmela Cerra, Marcello Canonaco
40
3/10 - DIFFERENTIAL MODULATION OF DOPAMINE-GLUTAMATE
POSTSYNAPTIC INTERACTION BY CAFFEINE AND NICOTINE AND
THEIR COMBINATION WITH ANTIPSYCHOTICS: RELEVANCE TO
PSYCHIATRIC DISEASES
Elisabetta Filomena Buonaguro
Livia Avvisati, Gianmarco Latte, Giovanna Fico, Camilla Avagliano, Federica
Marmo, Felice Iasevoli, Carmine Tomasetti, Andrea de Bartolomeis
4/10 - NICOTINIC ACETYLCHOLINE RECEPTORS CONTAINING ALFA5
SUBUNIT REGULATE DOPAMINE AND SEROTONIN BUT NOT
ACETYLCHOLINE RELEASE IN NUCLEUS ACCUMBENS: AN IN VIVO
MICRODIALYSIS STUDY USING ALFA5 KO MICE
Antonietta Vilella
Giuseppe Cannazza, Natalia Stasiak, Michele Zoli
5/10 - SIGNIFICANT CORRELATION BETWEEN LONG-TERM LITHIUM
TREATMENT AND LEUKOCYTE TELOMERE LENGTH IN PATIENTS
WITH BIPOLAR DISORDER
Claudia Pisanu
Gioia Baggiani, Donatella Congiu, Carla Melis, Paola Niola, Paola Caria,
Giovanni Severino, Roberta Vanni, Alberto Bocchetta, Maria Del Zompo,
Caterina Chillotti, Alessio Squassina
6/10 - DYSREGULATION OF GPR17, A NEW KEY ACTOR INVOLVED IN
OLIGODENDROGENESIS, IN A RODENT MODEL OF MULTIPLE
SCLEROSIS: IMPLICATIONS FOR RE-MYELINATION STRATEGIES
Giusy Tindara Coppolino
Davide Lecca, Davide Marangon, Francesca Viganò, Gianluca Menichetti,
Marta Fumagalli, Elisabetta Bonfanti, Roberto Furlan, Leda Dimou, Maria
Pia Abbracchio
7/10 - INHIBITION OF MONOACYLGLYCEROL LIPASE ACTIVITY
MODULATES THE ACTIVATION OF BRAIN STRUCTURES RELEVANT
FOR MIGRAINE PATHOGENESIS
Rosaria Greco
Tiziano Bandiera, Antonina Stefania Mangione, Chiara Demartini, Giuseppe
Nappi, Giorgio Sandrini, Fabio Blandini, Daniele Piomelli, Cristina Tassorelli
8/10 - NOVEL ANTISENSE AND PROTEIN CODING GENE VARIATIONS
IDENTIFIED BY NGS IN PARKINSON’S DISEASE
Marialuisa Valente
Roberta Zangaglia, Stella Gagliardi, Ivana Ricca, Susanna Zucca, Fabio
Blandini, Claudio Pacchetti, Cristina Cereda
41
9/10 - ALTERATIONS OF SYNAPTIC MECHANISMS AND EXCESSIVE
GLUTAMATE RELEASE IN THE SPINAL CORD OF SOD1G93A MICE
Tiziana Bonifacino
Marco Milanese, Laura Musazzi, Elena Gallia, Luca Cattaneo, Giulia
Treccani, Franco Onofri, Maurizio Popoli, Giambattista Bonanno
10/10 - THE TUMOR SUPPRESSOR NF2/MERLIN INDUCES SCHWANN CELL
CHANGES THROUGH HIPPO-DEPENDENT MECHANISMS
Simona Melfi
Alessandra Colciago, Veronica Bonalume, Giuseppe Giannotti, Lucia
Caffino, Fabio Fumagalli, Valerio Magnaghi
11/10 - A NEW CLINICALLY RELEVANT MURINE MODEL OF SPINAL CORD
INJURY MIMICKING THE PATHOLOGICAL FEATURES OF COMPLETE
PARALYSIS IN HUMANS
Valentina Vacca
Flaminia Pavone, Siro Luvisetto, Sara Marinelli
12/10 - HYDROGEN SULPHIDE: A GLIAL FACTOR ENDOGENOUSLY
OVERPRODUCED IN AMYOTROPHIC LATERAL SCLEROSIS THAT
ENHANCES MOTOR NEURON DEATH
Alida Spalloni
Viviana Greco, Ezia Guatteo, Nicola B. Mercuri, Andrea Urbani, Patrizia
Longone
13/10 - TREATMENT-RESISTANT PSYCHOSIS IN PATIENTS WITH
AUTOIMMUNE THYROIDITIS: A CASE SERIES
Francesco Traccis
Gioia Baggiani, Andrea Loviselli, Alberto Bocchetta
14/10 - A NEW TOOL FOR STORING AND INTERROGATING GENOTYPEPHENOTYPE CORRELATIONS TO STUDY BIPOLAR DISORDER
Carla Melis
Patricia Rodriguez-Tomé, Raffaella Ardau, Caterina Chillotti, Maria Del
Zompo, Alessio Squassina, Giovanni Severino
15/10 - SUMOYLATION OF NCX3 BY SUMO1 TAKES PART IN THE BRAIN
NEUROPROTECTION INDUCED BY ISCHEMIC PRECONDITIONING
Ornella Cuomo
Giuseppe Pignataro, Rossana Sirabella, Serenella Anzilotti, Pasquale
Molinaro, Antonella Scorziello, Claudia Savoia, Maria Josè Sisalli,
Gianfranco Di Renzo, Lucio Annunziato
42
16/10 - FOXG1 OVEREXPRESSION IN NEOCORTICAL NEURONS: A
VALUABLE TOOL TO DISSECT MECHANISMS UNDERLYING WEST
SYNDROME VARIANTS LINKED TO FOXG1 GENE DUPLICATION
Moira Pinzan
Minh Do Duc, Simone Chiola, Giovanni Provenzano, Yuri Bozzi, Antonello
Mallamaci
17/10 - SUPEROXIDE DISMUTASE 1: A NEW FUNCTION IN THE NUCLEAR
COMPARTMENT
Orietta Pansarasa
Stella Gagliardi, Michela Dell’Orco, Matteo Bordoni, Sabrina La Salvia,
Luca Diamanti, Elisa Maffioli, Gabriella Tedeschi, Cristina Cereda
18/10 - SIMILARITIES AND DIFFERENCES BETWEEN ALS AND IBM
Orietta Pansarasa
Andrea Cortese, Matteo Bordoni, Francesca Polveraccio, Lorenzo
Drufuca, Emanuele Buratti, Cristina Cereda
19/10 - SUPRAMODAL MIRROR AGNOSIA IN PATIENTS WITH
PERIVENTICULAR LEUKOMALACIA
Elisa Castaldi
Francesca Tinelli, Guido Marco Cicchini, Laura Biagi, Maria Concetta
Morrone
20/10 -CAN LOSS OF HETEROZYGOSITY EXPLAIN CEREBRAL
CAVERNOUS MALFORMATIONS’ DEVELOPMENT IN PATIENTS WITH
NO CCM GENES GERMLINE MUTATIONS?
Concetta Scimone
Concetta Alafaci, Alessia Ruggeri, Luigi Donato, Carmela Rinaldi, Rosalia
D’Angelo, Antonina Sidoti
21/10 - ROLE OF MELOXICAM ON GLUTAMATE AND GABA CYCLE
MODIFICATIONS IN RAT ORGANOTYPIC HIPPOCAMPAL SLICE
CULTURES EXPOSED TO OXYGEN-GLUCOSE DEPRIVATION
Elisa Landucci
Irene Lorenzo Llorente, Elisabetta Gerace, Arsenio Fernandez-Lopez,
Domenico Pellegrini-Giampietro
22/10 - IMPAIRMENT OF CORTICO-STRIATAL GLUTAMATERGIC SYNAPSES
IN TWO MOUSE MODELS OF HUNTINGTON’S DISEASE (HD)
Gerardo Biella
Francesca Talpo, Chiara Zuccato, Cattaneo Elena, Giulio Sancini, Mauro
Toselli
43
23/10 - PRION PROTEIN INFLUENCES ALPHA-SYNUCLEIN AGGREGATES
SPREADING IN MICE
Lara Masperone
Suzana Aulic, Elisa Isopi, Joanna Narkiewicz, Giuseppe Legname
24/10 - TRAF6 INVOLVEMENT IN PRION DISEASE: A POSSIBLE CROSSTALK
AMONG NEURODEGENERATIVE DISEASES
Lara Masperone
Silvia Zucchelli, Giuseppe Legname
25/10 - FUNCTIONAL CHARACTERIZATION OF A NOVEL MUTATION
AFFECTING THE FIRST ARGININE IN THE S4 SEGMENT OF KV7.2
CHANNEL CAUSING EARLY-ONSET EPILEPTIC ENCEPHALOPATHY
Francesco Miceli
Maria Virginia Soldovieri, Paolo Ambrosino, Edward C. Cooper, Maurizio
Taglialatela
26/10 - KNOCKING OUT THE NA+/CA2+ EXCHANGER NCX3 IMPAIRS
OLIGODENDROCYTE LINEAGE RESPONSES, ANTICIPATES THE
ONSET, AND INCREASES THE SEVERITY OF EXPERIMENTAL
AUTOIMMUNE ENCEPHALOMYELITIS
Antonella Casamassa
Francesca Boscia, Claudia La Rocca, Giuseppe Matarese, Lucio
Annunziato
27/10 - RHES INFLUENCES STRIATAL CAMP/PKA-DEPENDENT SIGNALING
AND SYNAPTIC PLASTICITY IN A GENDER-SENSITIVE FASHION
Veronica Ghiglieri
Francesco Napolitano, Barbara Pelosi, Valentina Pendolino, Carmela
Giampà, Chiara Schepisi, Sara Migliarini, Anna Di Maio, Daniela Vitucci,
Maria Mancini, Giuseppe Sciamanna, Giacomo Maddaloni, Francesco
Errico, Robert Nisticò, Massimo Pasqualetti, Barbara Picconi, Alessandro
Usiello
28/10 - RHES REGULATES DOPAMINE D2 RECEPTOR TRANSMISSION IN
STRIATAL CHOLINERGIC INTERNEURONS
Giuseppe Sciamanna
Francesco Napolitano, Barbara Pelosi, Paola Bonsi, Daniela Vitucci,
Tommaso Nuzzo, Daniela Punzo, Veronica Ghiglieri, Giulia Ponterio,
Massimo Pasqualetti, Antonio Pisani, Alessandro Usiello
29/10 - VGF PEPTIDES IN THE NSC-34 MOTONEURONAL CELL LINE:
SELECTIVE MODULATION UPON OXIDATIVE STRESS AND
POTENTIAL NEUROPROTECTIVE ROLE OF TLQP-21
Roberta Pilleri
Carla Brancia, Barbara Noli, Cristina Cocco, Valeria Sogos, Gian Luca Ferri
44
30/10 - A382T TARDBP GENE MUTATION ALTERS STRESS GRANULE
DYNAMIC IN CULTURED FIBROBLASTS FROM ALS PATIENTS
Paola Coni
Carla Brancia, Andrea Floris, Ilaria Bellini, Sandro Orrù, Valeria Sogos
31/10 - IMPAIRMENT OF SPIKE TIMING DEPENDENT PLASTICITY AT
IMMATURE MOSSY-FIBER–CA3 SYNAPSES OF MICE CARRYING
THE R451 MUTATION OF NL3 IS DUE TO A LOSS OF FUNCTION
Martina Sgritta
Andrzej Jan Bialowas, Grzegorz Wiera, Enrico Cherubini
32/10 - MOLECULAR MECHANISMS INVOLVED IN MITOCHONDRIAL
DYNAMICS IN AN IN VITRO MODELS OF BRAIN ISCHEMIA
Gaetano Ianniello
Maria Josè Sisalli, Lucio Annunziato, Antonella Scorziello
33/10 - CHARACTERIZATION OF THE NEURONAL ALTERATIONS IN THE
SHANK1/SHANK3 DOUBLE KNOCK OUT MOUSE AS ANIMAL
MODEL FOR SHANKOPATHIES
Adele Mossa
Luisa Ponzoni, Lorenza Culotta, Mariaelvina Sala, Carlo Sala, Chiara
Verpelli
34/10 - CHARACTERIZATION OF SELECTIVE MIRNAS EXPRESSION IN
BLOOD AND BRAIN SAMPLES AFTER THE NEUROPROTECTIVE
APPROACH OF REMOTE POSTCONDITIONING
Pasquale Cepparulo
Antonio Vinciguerra, Ornella Cuomo, Paola Brancaccio, Gianfranco Di
Renzo, Lucio Annunziato, Giuseppe Pignataro
35/10 - MICROVESICLES IN NEURODEGENERATIVE DISEASES:A CROSSTALK AMONG DIFFERENT CELL TYPES
Sabrina La Salvia
Daisy Sproviero, Federico Colombo, Orietta Pansarasa, Stella Gagliardi,
Laura Porretti, Cristina Cereda
36/10 - EFFECT OF PURIFIED MURINE NGF ON ISOLATED
PHOTORECEPTORS OF A RODENT DEVELOPING RETINITIS
PIGMENTOSA
Maria Luisa Rocco
Bijorn Omar Balzamino, Pamela Petrocchi Passeri, Alessandra Micera,
Luigi Aloe
45
37/10 - PHARMACOLOGICAL RESCUE OF KCNQ2 CHANNELS CARRYING
EARLY-ONSET EPILETIC ENCEPHALOPATHY MUTATIONS
Michela De Maria
Maria Virginia Soldovieri, Paolo Ambrosino, Ilaria Mosca, Francesco
Miceli, Pasquale Striano, Sarah Weckhuysen, Edward C Cooper, Maurizio
Taglialatela
38/10 - GENETIC VARIATION IN RASD2 MODULATES PSYCHOTOMIMETIC
DRUG EFFECTS IN MICE AND SCHIZOPHRENIA-RELATED
PHENOTYPES IN HUMANS
Francesco Napolitano
Daniela Vitucci, Annabella Di Giorgio, Francesco Errico, Maria Teresa
Attrotto, Barbara Gelao, Leonardo Fazio, Anna Di Maio, Valentina Marsili,
Paolo Taurisano, Giuseppe Blasi, Barbara Pelosi, Massimo Pasqualetti,
Alessandro Bertolino, Alessandro Usiello
39/10 - EFFECT OF RESVERATROL ON PLASMATIC MOLECULAR
INDICATORS OF BRAIN TISSUE RESPONSE TO THE
HYPOPERFUSION/REPERFUSION CHALLENGE
Laura Poddighe
Maria Pina Serra, Marianna Boi, Cristina Picci, Gianfranca Carta,
Elisabetta Murru, Sara Lisai, Annarita Sirigu, Maria Collu, Sebastiano
Banni, Marina Quartu
40/10 - RESVERATROL VIA SIRTUIN-1 DOWNREGULATES RE1-SILENCING
TRANSCRIPTION FACTOR (REST) EXPRESSION PREVENTING PCB95- INDUCED NEURONAL CELL DEATH
Giusy Laudati
Natascia Guida, Serenella Anzilotti, Paolo Montuori, Gianfranco Di Renzo,
Lorella Maria Teresa Canzoniero, Luigi Formisano
41/10 - TRANSPLANTED ADULT STEM/NEUROPROGENITOR CELLS
(ANPCS) IN RODENT MODELS OF PARKINSON’S DISEASE:
CHARACTERIZATION, PROPERTIES AND IN VIVO EVIDENCE OF
NIGROSTRIATAL DOPAMINERGIC NEURORESTORATION
Francesca L’Episcopo
Cataldo Tirolo, Nunzio Testa, Maria Francesca Serapide, Luca Peruzzotti
Jametti, Stefano Pluchino, Bianca Marchetti
42/10 - SHEDDING VESICLES RELEASE FROM A HUMAN MICROGLIAL
CELL LINE: A TOOL FOR STUDYING MICROVESICLES BIOLOGY
Federico Colombo
Giacomo Casella, Annamaria Finardi, Roberto Furlan
46
43/10 - NITRATED P53 AS AN EARLY BIOMARKER OF UNBALANCE REDOX
STATUS IN ALZHEIMER’S DISEASE (AD)
Daniela Uberti
Mariagrazia Marziano, Abate Giulia, Maurizio Memo
44/10 - INVOLVEMENT OF CENTRAL HISTAMINERGIC SYSTEM IN
THE PPAR-ALPHA LIGANDS INDUCED ANALGESIC AND
ANTIDEPRESSANT-LIKE EFFECTS IN MICE
Alessia Costa
Patrizio Blandina, Carla Ghelardini, Maria Beatrice Passani, Gustavo
Provensi
45/10 - CONFORMATIONALLY ALTERED P53 AFFECTS NEURON
BIOLOGICAL FUNCTIONALITY GIULIA ABATE
Marigrazia Marziano
Daniela Uberti, Maurizio Memo
46/10 - THE PROTECTION INDUCED BY L-BMAA-INDUCED
PRECONDITIONING IN AMYOTROPHIC LATERAL SCLEROSIS MICE
BEARING G93A MUTATION IS MEDIATED BY MODULATION OF
PROTEINS CONTROLLING IONIC HOMEOSTASIS
Giuseppe Simeone
Serenella Anzilotti, Antonio Vinciguerra, Ornella Cuomo, Paola
Brancaccio, Pasquale Cepparulo, Pierpaolo Cerullo, Lucio Annunziato,
Giuseppe Pignataro
47/10 - A ROLE FOR ENVIRONMENTAL CHEMICALS IN AUTISM
ETIOLOGY: GESTATIONAL EXPOSURE TO LOW DOSES OF THE
ORGANOPHOSPHATE INSECTICIDE CHLORPYRIFOS ENHANCES
OXIDATIVE STRESS IN A MOUSE MODEL OF AUTISM
Alessia De Felice
Luisa Minghetti, Anita Greco, Gemma Calamandrei
48/10 - CHF5074 (CSP-1103) INDUCES MICROGLIA ALTERNATIVE
ACTIVATION IN PRIMARY GLIAL CULTURES EXPOSED TO BETAAMYLOID AND IN PLAQUE-FREE TG2576 MICE
Vanessa Porrini
Annamaria Lanzillotta, Caterina Branca, Marina Benarese, Edoardo Parrella,
Luca Lorenzini, Laura Calzà, Raffaella Flaibani, PierFranco Spano, Bruno
Pietro Imbimbo, Marina Pizzi
47
49/10 - NEUTRALIZATION OF THE APOPTOTIC EFFECTS OF THE
NEUROTOXIC CYTOKINE TRAIL BY A NAN0PARTICLECONJUGATED SPECIFIC MONOCLONAL ANTIBODY
Nicole Ronsisvalle
Giulia Di Benedetto, Teresa Musumeci, Giovanni Puglisi, Renato
Bernardini, Giuseppina Cantarella
50/10 - THE TRAIL/GITRL INTERPLAY IN NEURODEGENERATIVE
PROCESSES IN THE HCN-2 HUMAN CORTICAL CELL LINE IN VITRO
Giulia Di Benedetto
Nicole Ronsisvalle, Renato Bernardini, Giuseppina Cantarella
51/10 - FUNCTIONAL READOUTS OF NEURONS DIFFERENTIATED FROM
HIPS DERIVED FROM PATIENTS AFFECTED BY HUNTINGTON’S
DISEASE
Elisabetta Cesana
Paola Conforti, Elena Cattaneo, Mauro Toselli, Gerardo Biella
52/10 - IN VIVO DOPAMINE AGONIST PROPERTIES OF ROTIGOTINE: ROLE
OF D1 AND D2 RECEPTORS
Sandro Fenu
Elena Espa, Augusta Pisanu, Gaetano Di Chiara
53/10 - WHITE MATTER DIFFUSION PARAMETERS IN MIGRAINE WITH AND
WITHOUT AURA
Nikoletta Szabo
Andras Kiraly, Peter Farago, Gergo Csete, Eszter Toth, Krisztian Kocsis,
Arpad Pardutz, Delia Szok, Janos Tajti, Laszlo Vecsei, Z Tamas Kincses
54/10 - NCX1 EXCHANGER COOPERATES WITH CALRETININ TO CONFER
PRECONDITIONING-INDUCED TOLERANCE AGAINST CEREBRAL
ISCHEMIA IN THE STRIATUM
Valeria de Rosa
Francesca Boscia, Antonella Casamassa, Agnese Secondo, Alba
Esposito, Anna Pannaccione, Rossana Sirabella, Giuseppe Pignataro,
Ornella Cuomo, Antonio Vinciguerra, Lucio Annunziato
55/10 - EARLY STAGE DETECTION OF ALPHA SYNUCLEIN ACCUMULATION
INDUCED CHANGES IN TRANSGENIC MOUSE MODEL OF
PARKINSON DISEASE: A DIFFUSION KURTOSIS IMAGING STUDY
Anas Arab
Amit Khairnar, Jana Kucerova, Peter Latta, Nikoletta Szabo
48
56/10 - ON THE USE OF THE POSITIVE AND NEGATIVE SYNDROME SCALE
IN RANDOMIZED CLINICAL TRIALS
Giorgio Marchese
Eraldo Nicotra, Gianluca Casu, Sara Piras, Mario Palomba
57/10 - EFFECTS PRODUCED BY M2 MUSCARINIC RECEPTOR ACTIVATION
IN BRAIN TUMORS: POSSIBLE THERAPEUTIC IMPLICATIONS
Ilaria Cristofaro
Francesca Mattei, Francesco Alessandrini, Zaira Spinello, Maria Di Bari,
Viviana Orlando, Luciano Conti, Ada Maria Tata
58/10 - NEUROPROTECTIVE AND ANTI-INFLAMMATORY PROPERTIES OF
MDG548, A NOVEL PPARG AGONIST, IN CHRONIC MPTP MODEL OF
PARKINSON DISEASE
Anna R. Carta
Daniela Lecca, Giovanna Mulas, Andrea Diana
59/10 - METFORMIN REVERSES THE DOPAMINERGIC
NEUROTOXICITY INDUCED BY REPEATED
3,4-METHYLENEDIOXYMETHAMPHETAMINE ADMINISTRATIONS
Pier Francesca Porceddu
Ismail Ishola, Micaela Morelli
60/10 - THE PHARMACOLOGICAL PROFILE OF THE DUAL RECEPTOR
GPR17
Gabriella Marucci
Michela Buccioni, Diego Dal Ben, Catia Lambertucci, Claudia Santinelli,
Andrea Spinaci, Ajiroghene Thomas, Maria Pia Abbracchio, Rosaria
Volpini
61/10 - A COMPREHENSIVE STUDY ON OLEUROPEIN AGLYCONE
BENEFICIAL EFFECTS IN THE TGCRND8 MOUSE MODEL OF ASS
DEPOSITION: A MECHANISTIC INSIGHT
Daniela Pantano
Pamela Nardiello, Leonardo Cavone, Andrea Lapucci, Ilaria Luccarini,
Massimo Stefani, Fiorella Casamenti
62/10 - TIME-COURSE OF THE PROTECTIVE EFFECT OF SELECTIVE
ADENOSINE A2A RECEPTOR AGONISTS AND ANTAGONISTS AFTER
BRAIN FOCAL ISCHEMIA IN THE RAT
Ilaria Dettori
Alessia Melani, Lucrezia Cellai, Felicita Pedata
49
63/10 - ALTERED ADULT NEUROGENESIS AND ENHANCED SEIZURE
PROPENSITY IN OLIGOPHRENIN-1 KNOCK-OUT MICE, A MURINE
MODEL OF X-LINKED INTELLECTUAL DISABILITY
Matteo Caleo
Manuela Allegra, Cristina Spalletti, Beatrice Vignoli, Stefano Azzimondi,
Irene Busti, Marco Canossa
64/10 - OREXINERGIC NEURONS IN MURINE MODELS OF ALZHEIMER’S
DISEASE
Anna Andrioli
Amenu Tolera Wirtu, Idris Azeez, Sophie Dix, Jill C. Richardson, Marina
Bentivoglio
65/10 - NEW THERAPEUTIC APPROACH FOR NEUROPATHIC PAIN: CELL
AUTOPHAGY MODULATION VIA ENERGY BALANCE REGULATION
Federica De Angelis
Valentina Vacca, Francesca Nazio, Sara Marinelli
66/10 - CHOLINERGIC SYSTEM ALTERATIONS IN MULTIPLE SCLEROSIS:
STUDIES IN RR-MS PATIENTS AND IN EAE MODEL
Ada Maria Tata
Maria Di Bari, Giovanni Di Pinto, Samanta Sperduti, Sabrina Galizia, Rocio
Alvarez, Marta Di Nicola, Chiara D’Angelo, Viviana Orlando, Guadalupe
Mengod, Valentina Gatta, Marcella Reale
67/10 - ROLE OF N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE
IN (NEURO) INFLAMMATION
Silvia Pontis
Valeria Capurro, Maria Summa, Natalia Realini, Alison Ribeiro, Ana Gujarro,
Andrea Armirotti, Angelo Reggiani, Daniele Piomelli
68/10 - THE SMALL GTP-BINDING PROTEIN RHES INFLUENCES MIDBRAIN
DOPAMINERGIC NEURONS: BEHAVIORAL AND BIOCHEMICAL
STUDIES
Annalisa Pinna
Francesco Napolitano, Giulia Costa, Jadwiga Wardas, Pier Francesca
Porceddu, Maria Antonietta Casu, Liliana Contu, Alessandro Usiello,
Micaela Morelli
69/10 - MOTOR AND COGNITIVE CHARACTERIZATION OF RHES KO
FEMALE MICE
Liliana Contu
Francesco Napolitano, Giulia Costa, Pier Francesca Porceddu, Jadwiga
Wardas, Annalisa Pinna, Alessandro Usiello, Micaela Morelli
50
70/10 - THE MONOMERIC GTP-BINDING PROTEIN RHES INFLUENCES
THE NUMBER OF MIDBRAIN DOPAMINERGIC NEURON AND THE
MOTOR DISTURBANCES ASSOCIATED TO L-DOPA IN 6-OHDALESIONED MICE
Alessandro Usiello
Francesco Napolitano
71/10 - ENDOCANNABINOIDS LEVELS IN SPECIFIC CEREBRAL AREAS OF
RAT FOLLOWING NITROGLYCERIN ADMINISTRATION: A POSSIBLE
ROLE IN MIGRAINE PAIN
Chiara Demartini
Rosaria Greco, Tiziano Bandiera, Ana Guijarro, Antonina Stefania
Mangione, Andrea Armirotti, Giuseppe Nappi, Fabio Blandini, Giorgio
Sandrini, Daniele Piomelli, Cristina Tassorelli
72/10 - HEART RATE VARIABILITY (HRV) AND CARDIOVASCULAR
MODULATION IN PARKINSON’S DISEASE PATIENTS WITH TREMOR
DOMINANT AND AKINETIC RIGID DOMINANT SUBTYPES
Paolo Solla
Christian Cadeddu, Antonino Cannas, Martino Deidda, Nicola Mura,
Giuseppe Mercuro, Francesco Marrosu
73/10 - ENDOCANNABINOID SYSTEM: POSSIBLE NEW TARGET IN THE
TREATMENT OF ANOREXIA NERVOSA
Roberto Collu
Maria Scherma, Valentina Satta, Jessica Bratzu, Maria Paola Castelli,
Maria Francesca Boi, Paolo Usai, Liana Fattore, Paola Fadda, Walter Fratta
74/10 - ALS MODELS, A CONTRIBUTE FROM PATIENT’S LYMPHOBLASTOID
CELL CULTURE
Orietta Pansarasa
Matteo Bordoni, Sabrina La Salvia, Marialuisa Valente, Lorenzo Drufuca,
Luca Diamanti, Stella Gagliardi, Cristina Cereda
75/10 - CHARACTERIZATION OF THE INTERACTION BETWEEN ALPHASYNUCLEIN AND PRION PROTEIN: A PUTATIVE OVERLAP OF TWO
NEURODEGENERATIVE DISEASES
Giuseppe Legname
76/10 - TRACTOGRAPHY OF WHITE MATTER CONNECTIONS PREDICTS
FOR VASCULAR COGNITIVE IMPAIRMENT IN HYPERTENSIVE
PATIENTS
Daniela Carnevale
Lorenzo Carnevale, Giulio Selvetella, Daniela Cugino, GIovanni Grillea,
Giuseppe Lembo
51
77/10 - EFFECT OF SIGMA-1 RECEPTOR (S1R) AGONISTS ON THE DISEASE
PROGRESSION OF SOD1.G93A MICE. LIGHTS AND SHADOWS
Daniela Curti
Nicola Secomandi, Antonio Vallarola, Marco Peviani, Nicole Sarno,
Alessandro Petese, AnnaMaria Marra, Daniela Rossi, Simona Collina
78/10 - INTENSIVE REHABILITATION ENHANCES LYMPHOCYTE BDNFTRKB SIGNALING IN PATIENTS WITH PARKINSON’S DISEASE
Giuseppe Frazzitta
Cecilia Fontanesi, Svetlana Kvint, Davide Ferrazzoli, Rossana Bera,
Alessandro Di Rocco, Gianni Pezzoli, Angelo Quartarone, Hoau Yan
Wang, Maria Felice Ghilardi
79/10 - PHARMACOLOGICAL CHARACTERIZATION OF THE SYNTHETIC
CANNABIMIMETIC COMPONENTS OF “SPICE” DRUGS: FOCUS ON
ABUSE LIABILITY
Barbara Loi
Maria Antonietta De Luca, Cristina Miliano, Alessandra Porcu, Mariella
Martorelli, Colin Davidson, Maria Paola Castelli, Fabrizio Schifano,
Gaetano Di Chiara
80/10 - EPIGENETIC AND TRANSCRIPTIONAL DYSFUNCTION IN ISCHEMIC
BRAIN INJURY AND HUNTINGTON’S DISEASE: FROM MECHANISMS
TO THERAPEUTIC CANDIDATES
Ferah Yildirim
Christopher W. Ng, Theresa A. Gipson, Malini Vashishtha, Christoph
Harms, Andreas Meisel, Leslie M. Thompson, David E. Housman, Ernest
Fraenkel
52
SCIENTIFIC INFORMATION
Posters
Researchers have been kindly invited to submit scientific abstracts that have been
reviewed by the examining Scientific Committee. All accepted posters will be
presented in a dedicated area of the Congress Center.
All poster will have to be on the display for the whole day the poster session refers
to, October 9 and 10.
Poster presenters are asked to remove their work at the end of each day.
The Organizing Secretariat takes no responsibility for the posters that will not be
removed.
SINS Secretary
Secretary of SINS will be available during the Congress.
Thursday, October 8 Friday, October 9
Saturday, October 10 Sunday, October 11
from 15.00 to 19.00
from 08.30 to 19.30
from 08.30 to 19.30
from 08.30 to 13.00
GENERAL INFORMATION
Congress Venue
Palazzo dei Congressi - Fiera Internazionale della Sardegna
Ingresso lato C.O.N.I. (Piazza Efisio Puddu)
Cagliari
Registration Desk
During the Congress the Organizing Secretariat will respect the following timetable:
Thursday, October 8
Friday, October 9
Saturday, October 10
Sunday, October 11
from 14.30 to 19.30
from 08.00 to 19.30
from 08.00 to 19.30
from 08.00 to 17.00
Cagliari October • 8th - 11th •2015
53
On site registration fees
SINS Members € 500
Non Members € 550
Under 35 Members SINS € 200
Under 35 Non Members € 250
Official language
The Official Language is English. No translation is provided.
Social event
Molentargius Parc Saline
Friday & Saturday, October 9 & 10, h 14.00-16.00.
Guided visit to the Molentargius Parc Saline. € 10
Molentargius is a Regional Parc located in Cagliari, regarded as one of the most
important humid areas in Europe, being a unique example of ecosystem within a
highly anthropic context, still an ideal habitat for several animals, included pink
flamingos. The visit offers a guided sightseeing around the park in an open-bus,
with several stops to watch flamingos in their natural environment, as well to visit
the salt basins and the old saltworks. Visits are programmed on October 9 and 10,
from 2:00 to 4:00 p.m.
Only on site registration are admitted, before Friday, October 9 at 12:00.
Congress dinner
Saturday, October 10 - Convento San Giuseppe in Cagliari.
In the unique frame of Convento San Giuseppe, at only 10 minutes driving from the
city centre, we welcome you to experience the ancient tastes of Sardinian tradition,
immersed in an intimate and joyful atmosphere of the central court of this historical
house, where the old tools of the traditional crafts witness the everyday life of
ancient knowledge.
Surrounded by Mediterranean essences aromas and the suggestive gardens,
you will taste, in an informal environment, the culinary specialties of Sardinia. The
roasters, intriguing fire masters, will offer you the ancient flavours. The square
will then become the dinner place, but with the freedom to take a seat in one
of the many suggestive corners of the Convento and to enjoy the unforgettable
atmosphere.
Registration are admitted on site, before Friday, October 9 at 12.00
54
Badges
All registered participants, speakers and exhibitors are requested to display their
personal badge received during the registration, in order to be admitted to the
Scientific Congress sessions and to each area of the Congress venue.
Lunches
Lunches on October 9 and 10 are included.
Only registered participants wearing badges are allowed to access to the catering
area.
Certificate of Attendance
Certificates of attendance will be available for all participants at the end of the
Scientific Congress.
Slide Centre – Speaker’s Ready Room
A slide centre will be available near Aula Magna.
All congress rooms will be equipped with personal computer and projector. It will
not be allowed to hook up personal laptops.
All speakers are kindly requested to go to the Speaker’s Ready Room for uploading
and preview their presentation at least 2 hours before the start of their session.
Exhibition Area
A permanent technical exhibition area will be set up respecting the Congress
Schedule.
55
Organizing Secretariat
PLS Educational
Via della Mattonaia, 17 - 50121 Firenze (FI)
Tel +39 055 24621 - Fax +39 055 2462270
[email protected]

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