2014-2015 Dermatology Newsletter

T H E
U N I V E R S I T Y
O F
C H I C AGO
D E R M AT O L O G Y
2 0 1 4 - 2 0 1 5 V o l u m e 9 A T
Inside
T H E
F O R E F R O N T
O F
S K I N
H E A L T H
A N N U A L
A N D
R E P O R T
R E S E A R C H
Dermatology Faculty Researchers Drs. Lang
and He: Setting Benchmarks for Skin Science
• Section Chief Letter | 2
• CDS Partnership | 2
• Drs. He and Lang
Lab Initiatives | 4-5
• Faculty in Focus | 6
• News From Clinic | 6
•Publications | 8-9
• Awards and Honors | 10
• Alumni Updates | 11
• Photo Quiz | 11
• Community Outreach | 11
•Residents | 12
T
he Section of Dermatology is pleased
to announce that Assistant Professor of
Medicine, Yu-Ying He, PhD, was awarded her
second NIH R01 grant for “Autophagy and
GG-NER in UVB-induced skin cancer.” This
award carries $1.125M in direct cost funding and
was also ranked in the top one percentile. The
overall goal of this proposal is to determine the
mechanism by which the catabolic process called
autophagy regulates global genome nucleotide
excision repair (GG-NER), a molecular system
for removal of bulky DNA damage caused by
environmental carcinogens including solar
ultraviolet B (UVB) radiation and air pollutants,
and its impact on UVB-induced skin tumorigenesis
and tumor progression. This edition of the Annual
Report highlights the momentum of the basic
science research faculty laboratories.
A Letter from the Section Chief
was recognized for her excellence
with a top one percentile ranking
on her second NIH R01 grant. The
timeliness of this award allows us
to focus this annual report on our
research endeavors. On page three
we highlight some research staff
presentation activities, following
pages outline some initiatives of
both the Dr. He and Dr. Deborah
Lang labs.
W
elcome to the ninth Annual
Report of The University of
Chicago Section of Dermatology.
This past academic year was filled
with research accomplishments,
residency education enhancements,
and many other newsworthy items.
As is evidenced by the lead
story, we are very proud of the
accomplishments of our basic
research scientists. Dr. Yu-Ying He
has worked tremendously hard and
Our Faculty in Focus column
features Dr. Diana Bolotin.
Dr. Bolotin has done much to
enhance the surgical didactics
for resident education, including
the addition of new teaching
equipment, more comprehensive
chapter reviews, and coordination
of “surgical wrap” sessions to
allow more practice opportunities.
The residents also hosted their
second annual retreat. This event’s
guest speaker, Edward F. X.
Hughes, MD, MPH, Professor of
Strategy and Preventive Medicine,
Feinberg School of Medicine at
Northwestern University, lectured
on the future of healthcare
as it pertains specifically to
dermatology. Several of our
esteemed program alumni also
participated in the group exercises.
We inaugurated a day of combined
lectures in partnership with the
Chicago Dermatological Society.
Hosted by The University of
Chicago Dermatology at the
Gleacher Center in downtown
Chicago, this activity comprised
not only our annual Dr. Allan
Lorincz Memorial Lecture, but
also the Dr. Maria Medenica
Dermatopathology lecture. We
were especially honored to have Dr.
Wayne Grayson of the University
of Witwatersrand, Johannesburg,
South Africa accept our invitation
to be the guest speaker for both
lectures.
Faculty honors are plentiful again
this year. Two of special note from
the Department of Medicine yearend ceremony are the awarding
of the 2015 Leif Sorensen Faculty
Research Award to Dr. Yu-Ying He
and the Postgraduate Education
Teaching Award to Dr. Sarah
Stein. We also welcomed Dr.
Farah Abdulla to our faculty as an
Assistant Professor of Medicine.
Please enjoy and keep in touch.
With all best wishes,
Christopher R. Shea, MD
Chief, Section of Dermatology
Eugene J. Van Scott Professor
in Dermatology
In Partnership with
CDS “Inspired Programming”
O
n Wednesday December 3, 2014 The University of Chicago
Section of Dermatology and the Chicago Dermatologic Society
INSPIRATIONAL
co-hosted the inaugural combined Dr. Allan L. Lorincz Memorial
Lecture and Dr. Maria Medenica Dermatopathology Lecture. This event
was hosted at the University of Chicago Gleacher Center in downtown
Chicago and the Section of Dermatology is pleased to showcase
this venue as the designated spot for many upcoming CDS monthly
meetings. The featured speaker for both lectures was Dr. Wayne
Grayson, Honorary Professor of Pathology in the School of Pathology,
University of Witwatersrand, Johannesburg, South Africa. The topics
Wayne Grayson, MBChB, PhD, FCPath
of Professor Grayson’s talks, respectively, were “Dermatopathology
of HIV/AIDS: Lessons Learned” and “Cutaneous Infections in Nonimmunocompromised Hosts.”
Dr. Wayne Grayson with U of C
Dermatology Residents in front of
the Wall of Nobel Laureates at the
Gleacher Center
2
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Research News
At the 2015 Society for Investigative Dermatology Conference in
LAB MEMBER UPDATES
Atlanta, Dr. Yu-Ying He made a platform presentation on “Epidermal
Takumi Iizuka, MS and her husband
SIRT1 Loss Disrupts Skin Barrier Integrity and Sensitizes Mice to
Joe welcomed their daughter Jane
Epicutaneous Allergen Challenge” (Ming M, Zhao B, Shea CR, Shah
Takako Baptist on August 8th, 2014.
P, Qiang L, White SR, Sims D, He YY) and presented a poster on
Takumi worked in Dr. Deborah Lang’s
“TGF-ß Signaling Links E-cadherin Loss to Suppression of UVB-
lab as a Research Tech and she is
induced DNA Repair”(Qiang L, Shah P, Barcellos-Hoff M, He YY).
missed. Congratulations!
Also at SID, Palak Shah,
Erica Littlejohn was awarded the
MS presented a poster
Thomas V. Getchell Memorial Award
on “p53 Target Gene
at the University of Kentucky. Erica
Sestrin2 Promotes AKT
is currently a doctoral candidate and
Activation and is Up-
graduate student there. Erica worked in
Regulated in Human SCC
L to R: Yu-Ying He, PhD, Keyoumars
Soltani, MD, Gloria Xu, MD (’07), Palak
Shah, MS
Dr. Deborah’s Lang’s lab as a Research
and Melanoma” (Zhao B,
tech. This award recognizes excellence in science and research and
Shah P, Qiang L, Ming M,
provides a travel stipend for a student participating in the Grant
Budanov A, Aplin A, Sims
Writing Workshop. Erica is committed to increasing diversity in health
D, He YY).
sciences through mentorship as she focuses on the areas of traumatic
brain injury and neurogenesis. She is published and presents at
Pritzker Medical Student Sasank Konda, on a summer research
national conferences.
rotation in Dr. Deborah Lang’s lab, presented his summary forum
talk on “Identification of a Novel Splice Variant of CXCR4 in Human
Melanoma,” and was awarded a stipend.
Graduate student Jason Lui, MS was awarded a full fellowship through the
University of Chicago Molecular and Cell Biology Training Grant. He will
continue to work in Dr. Deborah Lang’s lab for the remainder of his training.
Palak Shah, MS and Ashley Sample, BS, both members of the He
lab, presented at the 2014 Biomedical Sciences Cluster Retreat.
Jennifer Kubic, PhD, Elizabeth Little, PhD, Jason Lui, MS and Lei
Qiang, PhD all presented posters at the 2015 Department of Medicine
Research Day.
WELCOME NEW STAFF
ASHLEY SAMPLE, BS: I am a cancer biology
PhD student working in Dr. Yu-Ying He’s lab.
My project involves identifying novel functions
of p62 in squamous cell carcinoma. I grew up in
Pennsylvania and did my undergraduate studies
at Michigan State University. My hobbies include
playing trivia, watching hockey, and baking.
SIXIA XIAO, MS: I come from China and
currently work as a research technician in the Dr.
Deborah Lang lab. I enjoy watching Japanese
anime and playing video games in my free time.
My future vgoals have yet to be determined, but I
am excited to be here!
Ashley Sample, BS
Elizabeth Little, PhD
SEUNGWON YANG, PHD: I am from South
Korea. I earned a Ph.D. degree at Seoul National
University in August 2012. In Nov. 2014, I
joined Dr. He’s group as a postdoctoral scholar.
My projects in Dr. He’s lab have been focused
on understanding & identifying new molecular
Jennifer Kubic, PhD
Palak Shah, MS
mechanisms related to autophagy and cancer progression.
3
Research Summary: Dr. Deborah Lang Laboratory
Our research goals are to discover innovative and effective treatments
The laboratory is currently identifying novel, potential molecular
for melanoma by targeting innate pathways that occur during
targets and drugs for future melanoma treatments. The goals here are
normal melanocyte development and stem cell maintenance. We
to discover molecular pathway components, determine their function in
find that the normal molecular processes that regulate cellular
melanoma as well as their necessity and/or sufficiency to drive tumor
differentiation, homeostasis, growth, and migration of adult and
progression, and identify drugs that specifically target these proteins.
embryonic melanocytes are corrupted during melanoma tumorigenesis,
Using a candidate and unbiased strategy for identifying drugs and drug
progression, and metastasis. The discovery of these molecular pathways
targets, we are currently testing potential molecules targeting kinases
and knowledge on how they function will reveal new targets for future
and transcription factors in a mouse model of melanoma and in human
melanoma therapies.
cancer cells to determine effects on tumor initiation and progression.
(i) Transcriptional
(iii) Discovery of
pathways that
pathways that
drive melanoma
promote melanoma
progression. Many
metastasis.
of the processes
Metastatic spread
that drive cancer
of tumor cells is
progression are
major driver of
not abilities newly
melanoma morbidity
acquired by the
and mortality.
melanoma cell.
Lang Lab Students-Sasank Konda,
Akash Parekh, Benita Glamour
Rather, these
molecular drivers
L to R: Jennifer Kubic, PhD,
Elizabeth Little, PhD, Sixia Xiao, MS,
Deborah Lang, PhD, Jason Lui, MS
Determining
how cells initiate
migration and
involve factors that are active in developing melanocytes and in stem
then survive and thrive in distal locations will identify key molecular
cells. Our laboratory has identified the protein PAX3 as an active
pathways that can be targeted to prevent metastatic spread. Employing
promoter of melanoma progression. PAX3 is essential during normal
normal skin, primary cutaneous melanomas, and metastatic lesions, we
melanocyte development, acting to maintain cellular growth and
are creating mouse models of melanoma metastasis, whereby normal
survival while blocking differentiation. PAX3 also promotes these
melanocytes and tumor cells are tagged, isolated, and analyzed . These
cellular processes in the melanoma cell, and blocking this factor directly
models will provide insight into molecules that are differentially
inhibits tumor cell growth and survival. As a transcription factor, PAX3
expressed among these cell types.
controls the expression of several genes, so that altering the function of
PAX3 has broad molecular consequences. In our laboratory, we focus
(iv) Mechanisms of drug resistance. A major advance in melanoma
on understanding the function of PAX3 in melanoma and targeting the
therapeutics is the use of the small molecule inhibitor, vemurafinib,
PAX3 pathway as a therapeutic target.
which specifically targets cells carrying specific mutations in BRAF.
While treatment with this specific inhibitor drug has resulted in
Jason Lui-PhD Candidate Lang Lab
(ii) Identification
impressive therapeutic responses, the benefit is not durable for most
of small-molecule
patients. The mechanism for this loss of drug responsiveness is not
therapeutics and
fully understood. We have identified a transcriptional feed-forward
molecular targets
mechanism involving the promotion of the MET tyrosine kinase
in melanoma. The
receptor by ETS-family transcription factors. Both MET and its
clinical options for
ligand, HGF, are directly implicated in the development of vemurafinib
metastatic melanoma
resistance. We are currently determining the sufficiency and necessity
are limited, and
of ETS-family protein function and expression on drug resistance and
patient morbidity
melanoma progression.
and mortality are still
significant problems.
4
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Research Summary: Dr. Yu-Ying He Laboratory
Our research addresses the fundamental question of how cells respond
understanding the molecular basis for controlling the DNA damage
to radiation and chemicals from internal or external sources to cause
response.
cancer, with a focus on skin cancer. We use in vitro systems, clinically
relevant animal models, genetically modified mouse models, and
(iii) Molecular control of DNA repair. We focus on investigation
human patient samples to elucidate how intrinsic and extrinsic factors
of the molecular mechanisms controlling the versatile DNA repair
regulate DNA repair, DNA damage response, and cellular homeostasis
pathway nucleotide excision repair (NER). NER eliminates a wide
in order to understand cancer susceptibility. Because skin is an
variety of helix-distorting base lesions induced by ultraviolet B (UVB)
epithelial tissue, our findings are relevant to cancers of other epithelial
radiation, tobacco smoking, cisplatin and oxidative damage. Since key
tissues, and our research has the potential to identify new targets and
NER proteins are difficult to target directly, identification of upstream
strategies to improve prevention and treatment for both skin and other
regulators has the potential to provide valuable targets for enhancing
Palak Shah-PhD Candidate He Lab
epithelial cancers.
NER and therefore
Our long-term goal is
tumor suppression.
to identify previously
However, the
unrecognized,
molecular signaling
therapeutically
pathways regulating
accessible molecular
NER has been poorly
regulatory networks
understood. We focus
that predict
on the molecular
susceptibility to
mechanisms in
skin cancer, and to
regulating NER
improve our ability to
capacity. These
prevent and treat it.
Lei Qiang, PhD
findings have the
potential to yield safe and efficient targets to improve DNA repair
(i) Role of autophagy and p62 in tumor initiation and progression.
capacity and thereby to prevent skin cancer and other epithelial cancers.
Macroautophagy (hereafter autophagy) is a catabolic process by which
cellular proteins, cytoplasm, and organelles are captured and targeted
(iv) Extrinsic control of DNA repair and DNA damage response.
for proteolytic degradation in lysosomes. Autophagy dysfunction is
The mechanisms by which extrinsic factors cause skin cancer can
associated with multiple human diseases, such as neurodegeneration,
define molecular targets for better prevention and therapy. Organ
microbial infection, metabolic diseases, cardiovascular diseases,
transplant recipients (OTRs) have a 65 to 250-fold increased risk
aging, and cancer. The multidomain protein p62/A170/SQSTM1
of developing skin squamous cell carcinoma caused by treatment
(hereafter p62) has been shown to be both a selective autophagy
with immunosuppressants, and immunosuppression has been widely
substrate and an autophagy adaptor protein that acts as a link between
assumed to be the major extrinsic cause for increased skin cancer
ubiquitination and autophagy. Autophagy is a pleiotropic cell survival
susceptibility. However, the molecular mechanism by which this
mechanism with both pro- and anti-tumor effects. We focus on
occurs was unknown. We focus on the cell-autonomous molecular
elucidating the regulatory and functional role of autophagy in skin
mechanism of skin tumorigenesis caused by immunosuppressive
carcinogenesis and cancer progression.
drugs. These findings have the potential to provide new
opportunities and targets for developing better
(ii) Molecular control of DNA damage response.
Two crucial DNA damage response processes
in tumor suppression are apoptosis and
strategies to reduce the burden of this devastating
disease in OTRs, without compromising the lifesaving attributes of immunosuppressive drugs.
senescence, i.e., when the DNA damage burden
is large, cells “commit suicide,” or terminally
differentiate. Dysregulation of apoptosis or
senescence promotes tumor initiation and
progression. Our research is centered on
L to R: Palak Shah, MS, Lei Qiang, PhD,
Yu-Ying He, PhD, Seungwon Yang, PhD,
Ashley Sample, BS
5
Surgical
Wrap Sessions
FACULTY IN FOCUS
D
r. Diana Bolotin is an
Assistant Professor of
Medicine in the Section of
Dermatology at the University
of Chicago. She received her
BA degree with Honors in 1998
in Molecular and Cell Biology,
Biochemistry at The University of
California, Berkeley and completed
both her medical and graduate
training as part of the Medical
Scientist Training Program at
the University of Chicago. Her
PhD training, under Dr. Elaine
Fuchs’s mentorship, focused on
pathways regulating proliferation
and differentiation processes in
the epidermis and hair follicles.
She continued her clinical training
at the University of Chicago with
an internship in Internal Medicine
and residency in Dermatology,
where she served as the Chief
Resident. During her residency,
Dr. Bolotin was a recipient of both
a Chicago Dermatology Society
research award as well as Medical
Dermatology Society (MDS)
mentorship award. As part of her
MDS scholarship, Dr. Bolotin
studied cutaneous oncology
with Dr. Jean Bolognia at Yale
University. She pursued further
surgical training by completing
an American College of Mohs
Surgery and ACGME-certified
fellowship in Procedural
Dermatology and Mohs
Micrographic Surgery at
Northwestern University under
the mentorship of Dr. Murad
Alam. She was trained in complex
cutaneous oncology and cuttingedge cosmetic techniques, and
participated in numerous clinical
trials in procedural dermatology.
6
Dr. Bolotin rejoined the Section
in 2011, where she serves as an
Assistant Professor of Medicine,
Director of Dermatologic Surgery
and Ambulatory Practice Medical
Director for Dermatology. She
is excited to lead the expansion
of our Mohs and procedural
dermatology program. Dr.
Bolotin particularly enjoys the
collaborative relationships she
has forged with our colleagues in
Radiation Oncology, Head and
Neck Surgery and Plastic and
Reconstructive Surgery to provide
patients with complex cutaneous
malignancies the best and most
advanced treatment options as a
team. She is particularly interested
in translational research on
carcinogenesis and novel skin
cancer therapies. Dr. Bolotin has
authored multiple peer reviewed
journal articles and textbook
chapters, and given presentations
at many regional and national
dermatology meetings. She also
serves on the Editorial Board
for the Journal of the American
Academy of Dermatology
(JAAD) as well JAAD Case
Reports Journal. She is an active
reviewer for JAMA Dermatology,
Dermatologic Surgery, and New
England Journal of Medicine and
is an active member of several Task
Forces within the AAD and ASDS.
A
s the primary surgical attending
in the Section, Dr. Diana
Bolotin continues to seek ways
of expanding surgical education
opportunities for house staff. She has
initiated and currently leads quarterly
interactive surgical wrap sessions
to allow for additional practice.
These sessions incorporate the use
of SimSkin training models in lieu
of the former pig’s feet model. These
sessions highlight interesting surgical
closures, complications, or other
learning points encountered while
on a surgical rotation. The resident
who performed the procedure will
present the case with appropriate
photography and discussion. PGY-3
and 4 residents who are completing
their surgical rotations during the
quarter are expected to present at
the Surgical Wrap session for that
quarter. PGY-2 residents involved
in interesting cases, closures, or
complications are also encouraged
to present at the Surgical Wrap
session. The presenting residents
are expected to discuss potential
cases for presentation with their
supervising surgical attending. In
addition, each resident receives
individual surgical instrument kits.
In addition, Dr. Bolotin guides the
Surgical Textbook Review/Surgical
Lecture Series. In preparation
for this activity, selected topics
regarding dermatologic surgery will
be covered throughout the academic
year. This lecture series will be
presented by the surgical attending
faculty, and will include five board
review questions.
News from the Clinic
L to R: Jason Keeler, MPH, MBA –EVP & COO, University of Chicago
Medical Center, Jennifer Tang, RN, Kate Jones-VP, Ambulatory Care Services
O
n May 8, 2015 the University of Chicago Medical Center hosted the
2015 Nurses Awards Week Celebration. Congratulations to Jennifer
Tang, RN on her nomination for the Nursing Excellence in an Outpatient
Area Award. Jennifer currently serves as our Clinic Nursing Manager.
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Dermatology
Resident Retreat
Dr. Maria Medenica Dematopathology
Lecture and Dermatopathology Day
Rossitza Lazova, MD
Associate Professor of
Dermatology and Pathology
Director, Dermatopathology
Fellowship, Yale University
“Melanocytic Lesions:
Application of the Principles
of Mass Spectrometry in Arriving
at the Correct Diagnosis”
T
he University of Chicago
Dermatology Residency
Program held its annual Resident
Retreat in September 2014 at the
Logan Center for the Arts. The
keynote speaker was Dr. Edward
F. X. Hughes, Professor of Strategy,
Kellogg School of Management and
Professor of Preventive Medicine at
the Feinberg School of Medicine,
Northwestern University. Dr. Hughes
founded Northwestern University’s
Center for Health Services and Policy
Research and served as its Director
for seventeen years. He also served
as the Director of Kellogg’s Health
Enterprise Management Program
and is the founder of Kellogg’s
joint MD-MBA Degree Program.
He has played a central role in the
development of the Pharmaceutical/
Biotechnology/Medical Device
curriculum at Kellogg and
served as the Co-Director of the
Biotechnology Program. Dr. Hughes
also has additional areas of research
interests in the efficient utilization
of resources in healthcare; health
policy and economics; managed care
and leadership. His topic discussed
the future of healthcare, particularly
dermatology in the current political
and economic state. The residents
had the opportunity to listen to a
panel of alumni contributors: Shaily
Patel-Kesani, MD (’11), John Fox,
MD (’11), Olga Ulitsky, MD (’08)
and Justin Wasserman, MD (’10,
Fellow ’11). This educational and fun
event included team building games
based on The Price Is Right and
Jeopardy.
Edward F. X. Hughes, MD, MPH
Professor of Strategy
Professor of Preventive Medicine,
Feinberg School of Medicine (Courtesy)
T
he seventh annual
Dermatopathology Day at the
University of Chicago was held
on April 16, 2014. The keynote
speaker was Rossitza Lazova, MD,
Associate Professor of Dermatology
and Pathology and the Director of
Dermatopathology Fellowship at
Yale University.
Dr. Lazova graduated from
Sofia Medical University in Sofia
Bulgaria, trained in Clinical
Pathology and then immigrated to
the United States. In the U.S. she
completed a residency in Anatomic
and Clinical Pathology at the
University of Rochester Medical
Center in Rochester, New York
in 1996. Her dermatopathology
fellowship training was completed at
Thomas Jefferson Medical College
in Philadelphia under Dr. A. Bernard
Ackerman. Dr. Lazova subsequently
began her career at Yale University
School of Medicine at the rank of
Assistant Professor, Department of
Dermatology in 1997.
Dr. Lazova’s main interests are
in melanocytic lesions, particularly
Spitzoid neoplasms. She recently
introduced using imaging mass
spectrometry as a method to be
used in the diagnostic process for
difficult melanocytic lesions. She has
taught many courses and directed
numerous sessions nationally and
internationally. Dr. Lazova has been
Director of the Dermatopathology
Fellowship at Yale University for
more than ten years.
Residents and Fellows also
presented:
Juliana Basko-Plluska, MD: An
Atypical Melanocytic Proliferation
Arising in a Congenital Nevus
Alex Means, MD, MS: Nodular
Basal Cell Carcinoma Arising
Within a Port-Wine Stain of a Patient
with Chemoradiation Exposure in
Adulthood
Kristen Paral, MD: A Peculiar
Neoplasm with a Vasoformative
Appearance
Eduardo K. Moioli, MD,
PhD: Histopathologic Features in
Melanoma Staging and Reporting
“THE HEALING”
She looks through the window
And what does she see
A reflection of self
The shadow of Me
The deep-seated pain
The hollow within
Where to look now
Where to begin
Flaws in the window
Is all she can see
Where am I, she weeps
Why don’t I see Me
A teardrop reflects
The sorrow, the flight
And then she sees distant
A soothing, bright light
As softness spreads out
The healings begin
The crevasses yield
To beauty within
She looks to the window
Where one used to be
A doorway she sees now
And cries t ’is for Me
-by Vesna Petronic-Rosic, MD
7
2014 Publications
Alam M, Nodzenski M, Yoo S, Poon E, Bolotin D. Objective
structured assessment of technical skills in elliptical excision
repair of senior dermatology residents: a multirater, blinded
study of operating room video recordings. JAMA Dermatol
2014; 150: 608-12.
Basko-Plluska J, Kazlouskaya V, Spizuoco A, Elston DM. The
use of fluorescence microscopy to evaluate elastic fiber pattern
in melanocytic neoplasms. Am J Dermatopathol 2014; 36: 443-4.
Bolotin D, and Ortel B. Cancer of the Skin. In: Bope ET,
Kellerman RD, eds. “Conn’s Current Therapy 2014.”
Philadelphia: Elsevier Saunders 2014; 221-4.
Kaminska EC, Nwaneshiudu AI, Ruiz de Luzuriaga A,
Tsoukas M, Bolotin D. Giant cellulitis-like Sweet syndrome
in the setting of autoimmune disease. J Am Acad Dermatol
2014; e94-5.
Kamaria M, Shea CR, Chin RK, Cohen EE, Maggiore R,
Bolotin D. Eruptive cutaneous squamous cell carcinoma
and psoriasis: response to cetuximab. Clin Exp Dermatol
2014; 39: 604-7.
Kim IY, He YY. Ultraviolet radiation-induced nonmelanoma skin cancer: Regulation of DNA damage repair
and inflammation. Genes Dis 2014; 1: 188-98.
Kubic JD, Little EC, Lui JW, Iizuka T, Lang D. PAX3 and
ETS1 synergistically activate MET expression in melanoma
cells. Oncogene 2014; e-1-11.
Maitland ML, Levine MR, Lacouture ME, Wroblewski KE,
Chung CH, Gordon IO, Szeto L, Ratko G, Soltani K, Kozloff
MF, Hoffman PC, Salgia R, Carbone DP, Karrison TG, Vokes
EE. Evaluation of a novel rash scale and a serum proteomic
predictor in a randomized phase II trial of sequential or
concurrent cetuximab and pemetrexed in previously treated
non-small cell lung cancer. BMC Cancer 2014; 14: 5.
Ming M, Han W, Zhao B, Sundaresan NR, Deng CX, Gupta
MP, He YY. SIRT6 promotes COX-2 expression and acts as
an oncogene in skin cancer. Cancer Res 2014; 74: 5925-33.
Ming M, Qiang L, Zhao B, He YY. Mammalian SIRT2
inhibits keratin 19 expression and is a tumor suppressor in
skin. Exp Dermatol 2014; 23: 207-9.
Petronic-Rosic V. Melanoma. In: Bope ET, Kellerman RD,
eds. “Conn’s Current Therapy 2014.” Philadelphia: Elsevier
Saunders 2014: 254-6.
8
Polcari I, Becker L, Stein SL, Smith MS, Paller AS. Filaggrin
gene mutations in African Americans with both ichthyosis
vulgaris and atopic dermatitis. Pediatr Dermatol 2014; 31:
489-92.
Prieto VG, Shea CR. Trichoepithelioma. Medscape Reference.
Updated 2014; available at: http://emedicine.medscape.com/
article/1060049-overview.
Qiang L, He YY. Autophagy deficiency stabilizes TWIST1
to promote epithelial-mesenchymal transition. Autophagy
2014; 10: 1864-5.
Qiang L, Zhao B, Ming M, Wang N, He TC, Hwang S,
Thorburn A, He YY. Regulation of cell proliferation and
migration by p62 through stabilization of Twist1. Proc Natl
Acad Sci USA; 2014; 111: 9241-6.
Selim MA, Hoang M, Smoller B, Shea CR. Vulvar dermatoses
and infections. In: Prat J, Robboy SJ, Mutter GL, Bentley RC,
Russell P, Anderson MC, eds. “Pathology of the Female Genital
Tract,” 3rd edition. London: Churchill Livingstone 2014; 48-78.
Shea CR, Boos MD. Langerhans cell histiocytosis. Medscape
Reference. Updated 2014; available at: http://emedicine.
medscape.com/article/1100579-overview.
Shea CR. Review of “Neoplastic lesions of the skin” by Jose
A. Plaza, Victor G. Prieto. Lab Med 2014; 45: e139.
Shea CR, Boos MD. Dermatologic manifestations of mucous
cyst. Medscape Reference. Updated 2014; available at:
http://emedicine.medscape.com/article/1058145-overview.
Shea CR. Syringoma. Medscape Reference. Updated
2014; available at: http://emedicine.medscape.com/
article/1059871-overview.
Shea CR, Prieto VG. Dermatologic manifestations of Merkel
cell carcinoma. Medscape Reference. Updated 2014; available
at: http://emedicine.medscape.com/article/1100917-overview.
Stein SL. Dermatology. In: Stern S, Cifu AS, Altkorn D, eds.
“Symptom to Diagnosis; An Evidence-based Guide,” 3rd
edition. New York: McGraw-Hill 2014; 471-90.
Teng JM, Cowen EW, Wataya-Kaneda M, Gosnell ES,
Witman PM, Hebert AA, Mlynarczyk G, Soltani K,
Darling TN. Dermatologic and dental aspects of the 2012
International Tuberous Sclerosis Complex Consensus
Statements. JAMA Dermatol 2014; 150: 1095-101.
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Trinh N, Novice K, Lekakh O, Means A, Tung R. Use of a
brief educational video administered by a portable video
device to improve skin cancer knowledge in the outpatient
transplant population. Dermatol Surg 2014; 40: 1233-9.
Wang S, Basko-Plluska J, Tsoukas MM. Generalized,
pruritic skin eruption in an immunocompromised patient.
Dermatol Pract Concept 2014; 4: 37-8.
White LE, Horenstein MG, Shea CR. Xanthomas. In:
Lebwohl MG, Heymann WR, Berth-Jones J, Coulson I, eds.
“Treatment of Skin Disease: Comprehensive Therapeutic
Strategies,” 4th edition. New York: Mosby 2014; 804-7.
Xiong M, Rabkin MS, Piepkorn MW, Barnhill RL, Argenyi
Z, Erikson L, Guitart J, Lowe L, Shea CR, Trotter MJ, Lew
RA, Weinstock MA. Diameter of dysplastic nevi is a more
robust biomarker of increased melanoma risk than degree
of histological dysplasia: a case control study. J Am Acad
Dermatol 2014; 71: 1257-8.
Zhao B, Shah P, Budanov AV, Qiang L, Ming M, Aplin A,
Sims DM, He YY. Sestrin2 protein positively regulates
AKT enzyme signaling and survival in human squamous
cell carcinoma and melanoma cells. J Biol Chem 2014; 289:
35806-14.
PUBLICATION IN FOCUS
Kubic JD, Little EC, Lui JW, Iizuka T, Lang D. PAX3 and ETS1 synergistically activate MET expression in melanoma cells.
Oncogene (2015) 34, 4964-4974; doi 10.1038/onc 2014.420. Published online 22 December 2014.
W
hen melanoma metastasizes, it often leads to lethal
discovery of a regulatory pathway that promoted MET expression in
consequences. One way these cancer cells invade and become
melanoma cells. In this report, two different pathways were shown
metastatic is by overexpressing a number of oncogenes, including
to increase MET protein levels, and inhibition of these pathways led
the receptor MET. While MET is often overexpressed in melanoma,
to a reduction of MET and a decrease of melanoma cell growth and
this is not commonly due to gene mutations or amplifications; what
survival within cell cultures and mice. One of the signaling cascades
is causing this increase is generally unknown. One possibility is that
discovered was a feed-forward system, whereby the ligand for MET,
over expression may be driven by factors that positively activate the
HGF, enhanced the expression of the MET gene. This may have
MET gene directly. A research team lead by Deborah Lang, PhD,
highly impactful implications, since one mechanism for melanoma
Assistant Professor of Medicine in the Section of Dermatology, and
drug resistance is through HGF signaling from the connective tissue
Jennifer Kubic, PhD, with contributions by lab members Elizabeth
surrounding the tumor, and an increase in the MET receptor may be a
Little, PhD, Jason Lui, MS, and Takumi Iizuka, MS, outlined the
gateway for melanoma cells to escape this therapeutic repression.
9
Faculty Awards and Honors
JULIANA BASKO-PLLUSKA, MD
• Appointed to Dermatology Faculty as
a Clinical Associate of Medicine
DIANA BOLOTIN, MD, PhD
• Served as Resident/Fellow Abstract
Session Co-Chair at the 2014 American
Society for Laser Medicine and Surgery
Annual Meeting in Phoenix
• Invited speaker at the 2014 American
Academy of Dermatology Summer
Meeting in Chicago, Topic: Auricular
Reconstruction
• Elected to the Editorial Board of the
Journal of the American Academy of
Dermatology: Case Reports
• Nominated as a member to the
American Society for Dermatologic
Surgey Task Force: Guidelines
on Resource Management in a
Dermatology Practice in an
Academic Setting
YU-YING HE, PhD
•Awarded R01
“Autophagy
and GG-Ner in
UVB-induced
Skin Cancer” with
a total direct cost
of $1.2mil and a
top one percentile
HOUSESTAFF
HONORS
SOGYONG AUH, MD, PhD
• Received the 2014 American
Society for Dermatologic Surgery
Preceptorship Award
MARA BEVERIDGE, MD
• Presented a poster on “Painful
Nodules on the Skin: Thinking Beyond
Erythema Nodosum” (Beveridge MG,
Tsoukas M) at the 2014 Department of
Medicine Resident Scientific Session
• Earned the 2014 American Society
for Dermatologic Surgery Resident
Scholarship
MIN DENG, MD
• Received the 2014 American Society
for Laser Medicine and Surgery
Preceptorship Award (shared with Dr.
Jared Jagdeo)
• Invited oral presenter on the
“Utilization of Mohs Surgery Codes
in California from the 2012 Medicare
Database” (Deng M, Simokat C,
10
ranking. (see cover story)
• Invited lecturer to the NIH/NIEHS
in Research Triangle Park, Topic:
Mechanisms of UVA-Induced
Skin Cancer
• Selected as the recipient for the 2015
Leif Sorensen Faculty Research
Award. This award recognizes
and rewards the performance of
outstanding basic or translational
scientific research by advanced junior
and mid-career faculty members in the
Department of Medicine
DEBORAH LANG, PhD
• Named a scientific reviewer for the
NIH/ National Cancer Institute (NCI)
Omnibus Special Emphasis Panel
ZCA1 SRB-1
• Nominated as an Ad Hoc Member to
the Molecular Oncogenesis (MONC)
Study Section at NIH
• Served as a Melanoma Research
Scholar Review Board Member for
Outrun the Sun Foundation
VESNA PETRONIC-ROSIC, MD
• Received
a Secondary
Faculty
Appointment in
the University
Iyengar V) at the 2014 American
Society for Dermatologic Surgery
Annual Meeting in San Diego
• Contributing author on posters
presented by Dr. Diana Bolotin
at the 2014 American Society for
Dermatologic Surgery meeting in San
Diego: “Meta-analysis of the Effects
of Therapeutic Ionizing Radiation on
Incidence of Basal Cell Carcinoma”
(Deng M, Bolotin D) and 1st Place
Poster Winner “A Multicenter
Retrospective Cohort Study of Basal
Cell Carcinoma: Accuracy of Tumor
Diagnosis at Biopsy” (Whittington
A, Minkis K, Nodsenski M, Deng M,
Moioli E, Krol C, Tayebi B, Bolotin D,
Yoo S, Tung RC, Alam A)
• Contributing author on poster presented
by Dr. Keyoumars Soltani at the 2015
World Congress of Dermatology in
Vancouver on “Cutaneous Diffuse
Large B-cell Lymphoma Arising in the
Settling of Angioimmunoblastic T-cell
Lymphoma” (Deng M, Shea CR,
Soltani K)
• Presented poster on “ A Potential
Pitfall: Intravascular Basal Cell
Carcinoma-Mimicker on Mohs Frozen
Section” (Deng M, Nwaneshiudu A,
Yun D, Bolotin D, Petronic-Rosic
V, Iyengar V) at the 2015 American
of Chicago Department of Pathology
• Named Chairman and Speaker at the
15th World Congress on Cancers of
the Skin in Edinburgh, Scotland
• Invited Keynote Speaker for the
International Academy of Cosmetic
Dermatology (IACD) Session
during the 23rd World Congress
of Dermatology in Vancouver,
Canada
• Received 2015 University of Chicago
Medicine & Biological Sciences
recognition for Outstanding Service
in Patient Care
AISHA SETHI, MD
• Appointed Assistant Director of
Outreach in the University of
Chicago’s Center for Global Health
• Named a Fellow in the Emerging
Leaders Program of the Chicago
Council on Global Affairs
CHRISTOPHER R. SHEA, MD
• Received a Secondary Faculty
Appointment in the University of
Chicago Department of Pathology
SARAH STEIN, MD
•Selected as the
2015 recipient of
the Department
of Medicine’s
Postgraduate
Education
Teaching Award.
This award goes
to a faculty member demonstrating
excellence and/or leadership in
education at the fellowship level in
the Department (Medicine SubSpecialties, Dermatology) or at the
resident level in dermatology (photo)
• Directed the forum, “What’s Hot in
Pediatric Dermatology?” at the 2014
American Academy of Dermatology
Summer Meeting in Chicago
• Invited Speaker at the American
Medical Forum in Chicago
• Named to the University of
Chicago’s BSD Committee on the
Reappointment of Assistant Professors
(COROAP)
KEYOUMARS SOLTANI, MD
• Elected to a three-year term to the
BSD Faculty Advisory Committee on
Clinical/Translational Science
College of Mohs Surgery Annual
Meeting in San Antonio
ALEX MEANS, MD, MS
• Awarded a Women’s Dermatologic
Society Career Development Grant
for “ A Comprehensive Assessment of
Psychosocial Morbidity in Hidradenitis
Suppurativa” with faculty preceptor Dr.
Aisha Sethi and direct costs of $4,800
• Received the 2015 World Congress
of Dermatology Trainee Scholarship
in Vancouver to orally present “
A Comprehensive Assessment of
Psychosocial Morbidity in Hidradenitis
Patients”
• Earned the Residents and Fellows
Scholarship to orally present at the
2014 Cosmetic Surgery Forum in Las
Vegas on “Psychiatric Comorbidities in
Medical and Cosmetic Dermatology”
• Accepted participant for the Society on
Investigative Dermatology Residents
Retreat
EDUARDO MOIOLI, MD, PhD
• Invited and traveled to Brazil with
the Blade and Light Society with the
purpose of performing and teaching
Mohs surgery to local dermatologists
and surgeons
• Contributing author on poster presented
by Dr. Diana Bolotin for 1st Place
Poster Winner at the 2014 American
Society for Dermatologic Surgery
meeting in San Diego “A Multicenter
Retrospective Cohort Study of Basal
Cell Carcinoma: Accuracy of Tumor
Diagnosis at Biopsy” (Whittington
A, Minkis K, Nodsenski M, Deng M,
Moioli E, Krol C, Tayebi B, Bolotin D,
Yoo S, Tung RC, Alam A).
• Presented poster on “Tumor
Status at the Time of Excision of
Squamous Cell Carcinoma In Situ
(SCC-IS) in Immunocompetent and
Immunosuppressed Patients” (Moioli
E, Bolotin D) at the 2015 American
College of Mohs Surgery Annual
Meeting in San Antonio
ADAOBI NWANESHIUDU, MD, PhD
• Received the National Medical
Association first-place award for
Resident Symposium
• Presented posters for both
the American Society on
Dermatopathology Mentor ship and
Fellow-in Training Awards
• Earned the 2014 World Congress of
Dermatology oral presentation and
travel award
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Alumni Updates
MONIQUE KAMARIA-CHHEDA,
MD (’14):
Dr. Kamaria
married Dr.
Samir Chheda,
a radiologist
and native of
Philadelphia
on August
31, 2014
in Bartlett,
Illinois. They will reside in New Jersey.
TUNISIA FINCH-CORNELIUS, MD
(’12): Dr. Cornelius
and her husband,
James, proudly
share the news that
their daughter, Joan
Alivia Cornelius,
was born on
August 23, 2014.
She continues to
practice family
dermatology in the suburbs of Atlanta.
AMY DERICK, MD (’06):
Dr. Derick was
awarded the 2015
Distinguished
Service Award for
Early Achievement
by the Medical
& Biological
Sciences Alumni
Association of
the University of Chicago. This award
is intended for someone who graduated
within the last fifteen years and has
brought honor and distinction to the
University of Chicago’s Division of
Biological Services through research,
clinical care, and professional service.
JAMES ERTLE, MD (’72): Dr. Ertle
was the recipient of the Humanism in
Medicine Award at the 2015 annual
meeting of the American Academy of
Dermatology in San Francisco. This award
given once a year, is sponsored by the
Arnold P. Gold Foundation for “exemplary
compassion, empathy and respect for
patients and for excellence in the art of
medicine.” The award includes a stipend
and expenses for the Academy meeting.
DARRYL OBLE, MD, PhD (FELLOW
’08): Dr. Oble celebrated the birth of
daughter,
Alina Elle
Oble, on
August 19,
2014. Dr. Oble
remains on the
faculty of the
University of
Manitoba.
CARLOS PAZ, MD, PhD (’12): Carlos
and his wife,
Vivian,
celebrated
the first
birthday of
their daughter
Carolina
Amelia in
2014.
BRIAN PUCEVICH, MD (’12): Dr.
Pucevich, wife Juliann, and big sister
Elena welcomed brother Ethan in
2014. Dr. Pucevich continues to work
at expanding his family dermatology
practice in the Pittsburgh area.
T
he Section continues to be active in community events, especially
when the purpose is increasing public awareness of skin cancer.
Section faculty, residents, and nursing staff teamed up with sponsors
Women’s Dermatological Society, Chicago Dermatological Society,
Chicago Park District, and Valeant Pharmaceuticals for the 2014 Skin
Cancer Screening and Educational Outreach at North Avenue Beach on
August 2nd. The mission of this summer outreach event, the education
and awareness for individuals and families about safe sun practices
and the offering of free open-air skin cancer screenings on Chicago’s
busiest beach, was achieved with a record 647 people screened!
PHOTO QUIZ
Q:
What is this piece of honorably
retired lab equipment once
favored by Dr. Soltani?
DAVID WHITNEY, MD, MBA
(’84): Dr. Whitney was featured in two
University of Chicago publications
recently: the Alumnus Profile in the
Pritzker Pulse, Summer 2014 edition and
in Medicine on the Midway, Spring 2015.
His son, Eric, with Dr. Juliana Chyu
(’84), entered his first year in the Pritzker
School of Medicine.
A: AO Fluorome Illuminator: Model 645,
American Optical Co. (c. 1967)
Dr. Francis married Mr. Tarik Alim on
August 30, 2014 in the Rockefeller
Chapel on the Hyde Park Campus. She
continues in her role as Director of the
Hair Disorders Center of Excellence at
the NorthShore University Health System
in the northern suburbs of Chicago.
EDIDIONG KAMINSKA, MD (’13):
Dr. Kaminska and husband Jan celebrated
the birth of twin girls, Evelina Ama
Kaminska and Karolina Idara Kaminska,
on November 25, 2014. The family will
soon be moving to Los Angeles.
It was used in conjunction with a high-intensity mercury
source, and was designed for fluorescence microscopy.
SHANI FRANCIS-ALIM, MD (’12):
NAB Screening
11
PGY-2 Dermatology
Residents
CARLY ROMAN, MD completed
her undergraduate degree in Zoology
at Miami University in Oxford, Ohio.
She finished her medical degree at Case
Western Reserve University. Carly
mentored for the SMART program where
she mentored school-aged girls and taught them about selfconfidence, health and nutrition. She enjoys salsa dancing, cycling
and cooking.
HAIDER BANGASH, MD completed
his medical education at Aga Khan
PGY-2 Dermatology
Fellow
ADAOBI NWANESHIUDU MD, PhD
completed her undergraduate studies in
biology at Haverford College in 2003,
during which she spent a semester
abroad in Melbourne, Australia, studying
Aboriginal culture and health. She went
on to complete her medical training at
Temple University School of Medicine in
Philadelphia where she graduated with a
combined MD, PhD degree, and the Alpha Omega Alpha medical
honors society distinction in 2010. Her PhD dissertation in the
department of Microbiology and Immunology was on the role
of gamma-delta TCR+ T-cells in the pathogenesis of systemic
sclerosis. Subsequently, she completed her internship at Crozer
Chester Medical Center and her dermatology residency at The
University of Chicago Medicine. She has a strong interest in
academic dermatology/dermatopathology and has undertaken
different original research projects in dermatopathology, presented
at regional and national conferences, as well as published articles
in peer-reviewed journals. She enjoys her family, good food and a
good laugh, and loves to travel.
Medical College in Pakistan. He
has an array of clinical and research
experience that has exposed him to the
Welcome New Faculty
field of dermatology. Haider finished
The Section is pleased to welcome DR.
his transitional year in Internal Medicine at the University of
FARAH ABDULLA as an Assistant
Connecticut. He enjoys swimming, water polo, and theater.
Professor of Medicine in 2014. She
is a board-certified dermatologist and
dermatopathologist with specialty
training in the field of cutaneous
lymphomas. Her clinical and research
interests include the areas of cutaneous
T and B cell lymphomas as well as the
OLGA RADKEVICH-BROWN, MD,
provision of healthcare, in particular cancer care, to uninsured
and underserved people. She plans to start clinical trials in
PhD received her undergraduate degree
cutaneous lymphoma and work with her mentor, Dr Sonali Smith
in Biochemistry from the University of
in Oncology on translation research looking for ways to improve
Detroit Mercy. She went on to complete
the care of and development of new treatments for this disease.
her PhD in Cancer Biology from Wayne
State University, and completed her MD
Dr. Abdullah was most recently an American Association for the
Advancement of Science, Science and Technology Policy Fellow
in the Department of Defense. She has completed fellowships in
at the University of Michigan. Olga enjoys playing the piano,
cutaneous lymphoma at Stanford and dermatopathology at the
reading, and canoeing.
University of Cincinnati. Her dermatology residency training and
internship were also at the University of Cincinnati. Farah lives
with her husband in Chicago and enjoys reading and cardio barre
in her free time.
12
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Philanthropy in Focus: The Bernstein Family
Drs. Leslie Bernstein (L), Scott Phillips,
Joel Bernstein, and Keyoumars Soltani
Dr. Joel Bernstein (’79) and Mrs. Carole Bernstein
Dr. Joel Bernstein and his family have long been active in the University
of Chicago community. His father and extended family have all earned
degrees from this institution. His eldest son, Jeffrey, is married to Leslie
Bernstein, MD, an alumna (’07) of our dermatology residency program.
Joel himself graduated Alpha Omega Alpha from the Pritzker School of
Medicine. He completed his dermatology residency here under program
director Dr. Allan L. Lorincz and performed a clinical pharmacology
fellowship with Dr. Leon Goldberg. Dr. Bernstein stayed on our faculty
and later joined Northwestern University before embarking on a highly
successful career establishing a number of pharmaceutical companies.
He has received numerous awards in business and entrepreneurship.
Dr. Joel Bernstein, along with Dr. Eugene J. Van Scott, Dr. David
Whitney, and Dr. Juliana Chyu, co-founded The University of Chicago
Friends of Dermatology fund. He and his wife, Carole, are avid art
collectors and have donated works of art to various museums, including
the Smart Museum of Art at the University of Chicago. Joel also
currently serves as a member of the Visiting Committee to the Division
of the Humanities. The Section is immensely thankful for the continuing
I have been gratified to
see the vastly increased
and important research
contributions made by
the Section under the
guidance of Drs. Shea
and Soltani.
support of the Bernstein family to its academic programs.
Leslie Bernstein, MD (’07)
Dr. Leslie Bernstein completed training in internal medicine prior
to being accepted into our Dermatology Residency Program. She is
married to Jeffrey Bernstein, PhD, the eldest son of Joel. They live in
the northern suburbs of Chicago. Leslie is very busy both in private
practice and in the care of their young children. Leslie and Jeffrey
are also generous donors to the Section’s academic programs and
participate in events as their schedules allow.
13
AAD Denver — March 2014
Graduation Dinner — June, 2014
Summer AAD — August 2014
Winterfest — February 2015
AAD San Francisco — March 2015
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Farewell to Emily Ayala — August 2014
Dr. Shea with residents
Farewell to Baozhong Zhao — August 2014
BIOLOGICAL SCIENCES DIVISION
Dermatology
5841 South Maryland Avenue
MC 5067
Chicago, Illinois 60637
Closing Message
Please share your alumni
news, archival photos, or your
current contact information
with us.
University of Chicago
Section of Dermatology
5841 South Maryland Avenue
MC 5067
Chicago, Illinois 60637
Tel 773.702.6559
A
glance at this issue of our annual report will demonstrate the major
scientific contributions to the field of skin cancer by our investigative
teams, led by Drs. Yu-Ying He and Deborah Lang. These great scientists
and their PhD students, post-doctoral fellows, and technicians are
advancing integumentary science with the goal of discovering novel
approaches to prevent and treat cutaneous tumors. Their efforts are
supported by highly competitive extramural funds from NIH and other
national granting agencies and — just as importantly — by the continued
generosity of our alumni and friends. Your continuing donations to our
several endowed funds are vital not only to advancing laboratory research,
but also to furthering our broader academic mission of training residents,
Fax 773.702.8398
fellows, and medical students, all while providing first-rate dermatologic
Email: [email protected]
support and encouragements. I hope to see many of you in your visits to
care to our patients. I personally thank all of you for your continued
the University of Chicago, and at our AAD reunions.
Keyoumars Soltani, MD