supplementary figures - QIMR Genetic Epidemiology

Transcription

SUPPLEMENTARY FIGURES
Supplementary Figure 1. Age-associated genes in discovery and replication samples.
(1A) Manhattan mirror plot of the whole blood expression-age discovery meta-analysis. Each dot represents a
gene; the x-axis gives the position of the gene on the genome (chr 1 – chrY), and the y-axis represents the
direction of the effect (-/+) and the p-value of the association (-logP). (1B) The scatterplot illustrating the
correlation between the discovery z-scores and the replication z-scores of the 1,497 age-associated genes.
1
Supplementary Figure 2. Venn diagram for overlapping genes between whole blood and brain tissue.
Venn diagram for the age-associated genes identified in the analyses for whole blood, cerebellum, and frontal
cortex. 88 genes were differentially expressed with age across all three tissues.
2
Supplementary Figure 3. Match quality of random genes selected for methylation-expression enrichment
analysis.
(3A) Distribution of gene length of 1,497 age-associated genes and 1,497 random genes (matched on gene length
and the log of mean expression as described in Methods). (3B) Distribution of log mean expression of 1,497 ageassociated genes and 1,497 random genes. (3C) Distribution of mean expression of 1,497 age-associated genes
and 1,497 random genes. (3D) Distribution of number of proximal CpG sites (within 250kb) of 1,497 ageassociated genes and 1,497 random genes.
3
Supplementary Figure 4. Quantile-Quantile (QQ) plots of the 1,497 age-associated genes versus 1,497
random genes, separately by cohort.
A.
B.
C.
4
D.
E.
F.
5
G.
Q-Q plots of the observed P values (-log10P) for the methylation~age associations (left panels) and the
methylation~expression associations (right panels). The plots in black show P values from the 1,497 significant
age-associated genes, whereas the plots in red and blue show P values for 1,497 random genes. Plots A-G
represent the results for the separate cohorts with methylation data: (4A) EGCUT, (4B) INCHIANTI, (4C)
BSGS, (4D) GTP, (4E) KORA, (4F) RS, and (4G) GARP. These plots were the basis for Figure 2, which shows
the results of the meta-analysis across all cohorts.
6
Supplementary Figure 5. Quantile-Quantile (QQ) plots of the 1,497 age-associated genes versus 1,497
random genes, separately by genomic region.
A.
B.
C.
7
D.
E.
F.
8
G.
H.
I.
9
J.
Q-Q plots of the observed P values (-log10P) for the methylation~age associations (left panels) and the
methylation~expression associations (right panels). The plots in black show P values from the 1,497 significant
age-associated genes, whereas the plots in red and blue show P values for 1,497 random genes. Plots A-G
represent the results for different genomic regions: (5A) CpG-islands, (5B) Off-island, (5C) Shores, (5D)
Shelves, (5E) Promoters, (5F) Non-promoters, (5G) Enhancers, (5H) Non-enhancers, (5I) Insulators, and (5J)
Non-insulators.
10
Supplementary Figure 6. Odds ratios for enrichment of CpG sites with significant Sobel test p-values for the different genomic regions.
Each odds ratio is based on comparison of CpG sites within 250kb of the 1,497 age-associated genes with significant Sobel test p-values (N=8,234) vs. other CpG sites within 250kb
of the 1,497 age-associated genes (N=191,832). Vertical bars represent the 95% confidence interval for each odds ratio. Strong enhancers, weak enhancers, insulators, and off island
regions were enriched for CpG sites with significant Sobel test p-values.
11
Supplementary Figure 7. Comparison of the transcriptomic and epigenetic age prediction methods.
A.
(7A) The top figure represents the correlation between transcriptomic age (y-axis) and chronological age (xaxis). The figures in the middle show the correlation between epigenetic age (y-axis: left = Horvath, right =
Hannum) and chronological age (x-axis). The figures at the bottom explain the correlation between the
transcriptomic predictor (x-axis) and the epigenetic age (y-axis: left = Horvath, right = Hannum) – results based
on a selection of 671 Rotterdam Study samples having both gene expression & DNA methylation data available.
12
B.
(7B) The top figure represents the correlation between transcriptomic age (y-axis) and chronological age (xaxis). The figures in the middle show the correlation between epigenetic age (y-axis: left = Horvath, right =
Hannum) and chronological age (x-axis). The figures at the bottom explain the correlation between the
transcriptomic predictor (x-axis) and the epigenetic age (y-axis: left = Horvath, right = Hannum) – results based
on a selection of 725 KORA samples having both gene expression & DNA methylation data available.
13
Supplementary Figure 8. Overview of the study design.
Affymetrix probe IDs and Illumina probe IDs have been combined to be able to run one meta-analysis on 11,908
overlapping genes. 2,228 genes were significantly associated with age in the discovery meta-analysis (p<4.2E-6),
and 1,497 genes have been replicated in the replication meta-analysis (p<2.2E-5). The 1,497 replicated ageassociated genes have been checked in other tissues and ethnicities (p<0.05).
14
Supplementary Figure 9. Age distributions of the discovery (A-F), replication (G-N), and generalization
cohorts (O-V).
15
(9A) KORA, (9B) INCHIANTI, (9C) SHIP-TREND, (9D) EGCUT, (9E) RS, (9F) FHS-OFFSPRING(GEN2:
EXAM 8), (9G) BSGS, (9H) DILGOM, (9I) FEHRMANN, (9J) FHS-GEN3 (GEN3: EXAM 2), (9K) GTP,
(9L) HVH (v3), (9M) HVH (v4), (9N) NIDDK/PHOENIX, (9O) EGCUT (CD4+ and CD8+ cells), (9P) GARP
(PBMCs), (9Q) GENOA (LCLs), (9R) BOSTON COHORT (CD4+ and CD14+ cells), (9S) PBMC-MS
(PBMCs), (9T) MESA (monocytes), (9U) NABEC-UKBEC (brain cells), (9V) SAFS (lymphocytes).
16
Supplementary Figure 10. Calibration of the parameter lambda (λ) for the approximate ridge regression
analysis in the BSGS cohort.
Lambda (λ) is the shrinkage parameter that is used to estimate effect sizes in the ridge regression (see methods).
We re-ran the meta-analysis excluding the BSGS cohort. We performed the approximate ridge regression
analysis with a range of lambda values, and calculated the correlation between the predictor and the actual age in
BSGS (shown on y-axis). Shown on x-axis is lambda / n with n being the sample size of the meta-analysis
(excluding BSGS). The maximum prediction accuracy is achieved at lambda = 6.07 * n with n being the sample
size.
17
SUPPLEMENTARY TABLES
Supplementary Table 1. The number of age-associated genes across different ancestries.
Caucasian
(meta-analysis)
15,266
Native American
(NIDDK/Phoenix)
1,457
Hispanic
(SAFHS)
1,244
African American
(GTP)
359
1,497
1,424
595
1,481
100.0%
95.1%
39.7%
98.9%
# expressed genes - same direction
1,326
562
1,219
% SAME DIRECTION
93.1%
94.5%
82.3%
# expressed genes - same direction & p<0.05
1,005
440
392
% GENERALIZED
70.6%
73.9%
26.5%
# samples
# expressed genes
% EXPRESSED
Supplementary Table 2: The number of age-associated genes across different tissue types.
Whole blood Cerebellum Frontal cortex
CD4+
CD8+
CD14+
LCLs
Lymphocytes
PBMCs
# samples
15,266
394
394
515
299
567
869
1244
362
# expressed genes
1,497
860
882
1,470
1,203
1,473
1,315
595
1,497
100.0%
57.4%
58.9%
98.2% 80.4%
98.4%
87.8%
39.7%
100.0%
414
438
1168
1100
1020
596
562
1126
48.1%
49.7%
79.5% 91.4%
69.2%
45.3%
94.5%
75.2%
163
229
400
220
440
328
19.0%
26.0%
27.2%
16.7%
73.9%
21.9%
% EXPRESSED
# expressed genes - same direction
% SAME DIRECTION
# expressed genes - same direction & p<0.05
% GENERALIZED
440
663
29.9% 55.1%
18
Supplementary Table 3: A matrix of shared age-associated genes across different tissues.
Tissue
(# age-associated genes)
Whole blood
(1,497 genes)
Cerebellum
(860 genes)
Frontal cortex
(882 genes)
CD4+
(1,470 genes)
CD8+
(1,203 genes)
CD14+
(1,473 genes)
LCLs
(1,315 genes)
Lymphocytes
(595 genes)
PBMCs
(1,497 genes)
Whole blood
(1,497 genes)
1,497
163
229
440
663
400
220
440
328
Cerebellum
(860 genes)
163
163
88
53
79
63
18
43
26
Frontal cortex
(882 genes)
229
88
229
76
107
82
35
69
40
CD4+
(1,470 genes)
440
53
76
440
283
132
63
165
131
CD8+
(1,203 genes)
663
79
107
283
663
180
111
238
169
CD14+
(1,473 genes)
400
63
82
132
180
400
55
137
73
LCLs
(1,315 genes)
220
18
35
63
111
55
220
64
52
Lymphocytes
(595 genes)
440
43
69
165
238
137
64
440
111
PBMCs
(1,497 genes)
328
26
40
131
169
73
52
111
328
19
Supplementary Table 4. 34 genes encoding ribosomal subunits were significantly associated with age: 33 were negatively associated with age.
UNIQUEID
48072
13742
9389
40921
60831
45616
17817
67967
45323
42546
62881
19552
32696
55317
46193
34217
48839
17484
66008
52719
4260
45816
57181
45497
14935
18988
68466
48699
11427
58212
65095
63762
62334
49929
RANK
38
317
356
374
387
414
432
451
453
478
596
610
615
704
711
730
791
887
910
973
1071
1098
1159
1167
1255
1257
1275
1303
1338
1404
1413
1458
1460
1472
GENID
RPL22
RPS6
RPS4X
RPL18
RPL13
RPS23
RPL8
RPS13
RPL5
RPLP0
RPSAP58
RPS2
RPL13P5
RPL19
RPP40
RPS16
RPL4
RPL36
RPS20
RPS14
RPL13AP3
RPL28
RPS29
RPL17
RPSA
RPS6KB1
RPP21
RPL11
RPL27A
RPL30
RPL35
RPS6KA1
RPL23AP64
RPS18
WEIGHT
15266
15266
15266
15266
15266
14385
14385
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
12620
15266
15266
15266
15266
15266
15266
15266
15266
15266
ZSCORE
-20.987
-12.692
-12.083
-11.924
-11.827
-11.561
-11.474
-11.319
-11.302
-11.116
-10.241
-10.167
-10.136
-9.742
-9.709
-9.618
-9.392
-9.014
-8.921
-8.643
-8.28
-8.187
-8.001
-7.955
-7.666
-7.647
-7.558
-7.47
-7.34
-7.113
-7.053
6.798
-6.773
-6.628
DIRECTION
+
-
P-VALUE
8.61E-98
6.57E-37
1.29E-33
8.87E-33
2.85E-32
6.49E-31
1.78E-30
1.06E-29
1.28E-29
1.04E-28
1.30E-24
2.77E-24
3.81E-24
2.00E-22
2.77E-22
6.72E-22
5.87E-21
1.99E-19
4.60E-19
5.49E-18
1.23E-16
2.67E-16
1.24E-15
1.79E-15
1.77E-14
2.06E-14
4.08E-14
8.03E-14
2.14E-13
1.14E-12
1.75E-12
1.06E-11
1.26E-11
3.41E-11
20
Supplementary Table 5. 10 genes encoding mitochondrial ribosomal genes were significantly associated with age: all were negatively associated with age.
UNIQUEID
54318
34287
44427
36113
13521
6683
35886
14726
22151
36300
RANK
480
641
794
820
840
866
894
1025
1128
1492
GENID
MRPL45
MRPS27
MRPL3
MRPL24
MRPS26
MRPS31
MRPS18B
MRPS33
MRPS9
MRPL35
WEIGHT
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
ZSCORE
-11.083
-9.994
-9.38
-9.285
-9.196
-9.057
-8.984
-8.447
-8.098
-6.419
DIRECTION
-
P-VALUE
1.52E-28
1.62E-23
6.61E-21
1.62E-20
3.71E-20
1.34E-19
2.61E-19
2.99E-17
5.58E-16
1.37E-10
21
Supplementary Table 6. The number of whole blood functional cluster genes significantly associated with age across the different tissues.
Functional cluster
(# genes expressed)
+1
Whole blood
(278 genes)
77
Cerebellum
(131 genes)
4
Frontal cortex
(136 genes)
6
CD4+
(275 genes)
40
CD8+
(228 genes)
42
CD14+
(277 genes)
21
LCLs
(252 genes)
10
Lymphocytes
(129 genes)
32
PBMCs
(278 genes)
10
+2
9
2
6
4
4
5
5
4
1
+3
8
0
1
1
2
2
2
2
0
+4
6
2
3
2
4
2
0
1
0
-1.1
50
5
9
6
19
28
1
23
19
-1.2
37
7
5
8
18
23
1
14
11
-1.3
22
3
2
6
14
3
1
6
7
-2
57
1
1
11
23
10
17
17
17
-3
12
0
0
1
8
9
4
1
0
AVG # of SIGN functional clusters genes
278
24
33
79
134
103
41
100
65
Supplementary Table 7. The percentage of whole blood functional cluster genes significantly associated with age across the different tissues.
Functional cluster
(# genes expressed)
+1
Whole blood
(278 genes)
100.0%
Cerebellum
(131 genes)
5.2%
Frontal cortex
(136 genes)
7.8%
CD4+
(275 genes)
51.9%
CD8+
(228 genes)
54.5%
CD14+
(277 genes)
27.3%
LCLs
(252 genes)
13.0%
Lymphocytes
(129 genes)
41.6%
PBMCs
(278 genes)
13.0%
+2
100.0%
22.2%
66.7%
44.4%
44.4%
55.6%
55.6%
44.4%
11.1%
+3
100.0%
0.0%
12.5%
12.5%
25.0%
25.0%
25.0%
25.0%
0.0%
+4
100.0%
33.3%
50.0%
33.3%
66.7%
33.3%
0.0%
16.7%
0.0%
-1.1
100.0%
10.0%
18.0%
12.0%
38.0%
56.0%
2.0%
46.0%
38.0%
-1.2
100.0%
18.9%
13.5%
21.6%
48.6%
62.2%
2.7%
37.8%
29.7%
-1.3
100.0%
13.6%
9.1%
27.3%
63.6%
13.6%
4.5%
27.3%
31.8%
-2
100.0%
1.8%
1.8%
19.3%
40.4%
17.5%
29.8%
29.8%
29.8%
-3
100.0%
0.0%
0.0%
8.3%
66.7%
75.0%
33.3%
8.3%
0.0%
AVG % of SIGN functional clusters genes
100.0%
11.7%
19.9%
25.6%
49.8%
40.6%
18.4%
30.8%
17.1%
22
Supplementary Table 8. The candidate genes carried forward to replication.
GENEID
Lookup
GENEID
LRRN3
CCR7
CD27
IGJ
LRRN3
CCR7
CD27
IGJ
LDH2
LDHB
VEGFB
ATM
FOXO1
VEGFB
ATM
FOXO1
IL7R
CAMK4
SREBF1
CD28
IL7R
CAMK4
SREBF1
CD28
LMNA
LMNA
ICSBP1
IRF8
CD70
MRPS26
MRPL45
CD70
MRPS26
MRPL45
FCGR1
FCGR1A
EIF4G3
MRPS18B
WRN
MRPS27
MRPL24
MRPS9
MRPL3
MRPS31
STAT3
MRPS33
ANXA5
NFKB1
RPS6KB1
S6K
MRPL35
FOXO3A
MRPS6
LYZ
CTSZ
MRPL46
ADARB1
GRN
MRPL36
CETP
EIF4G3
MRPS18B
WRN
MRPS27
MRPL24
MRPS9
MRPL3
MRPS31
STAT3
MRPS33
ANXA5
NFKB1
RPS6KB1
RPS6KB1
MRPL35
FOXO3
MRPS6
LYZ
CTSZ
MRPL46
ADARB1
GRN
MRPL36
CETP
SLC25A17
SLC25A17
CDKN2B
CDKN2B
Reason
Markers of naïve/differentiated cells
Multi-tissue, multi-species candidate
Downregulated in mice and humans
w/ageing in multi-tissue analyses
MTOR/FOXO pathways
Key DNA repair gene
MTOR/FOXO pathways
Age and longevity expression
association
Longevity genetics candidate
MTOR/FOXO pathways
Hutchinson-Gilford Progeria
syndrome
Upregulated in mice and humans
Mitochondrial ageing results
Upregulated in mice and humans
MTOR/FOXO pathways
Werner syndrome
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
Downregulated in mice and humans
Longevity candidate gene
exp.
dir
Citation(s)
RANK
Dir
disc-p
repl-p
+
Chou et al. 2013
Chou et al. 2013
Chou et al. 2013
de Magalhaes/Church 2009
2
5
9
68
-
2.03E-186
3.59E-99
1.07E-69
6.52E-19
7.81E-247
1.48E-111
5.13E-95
1.08E-65
-
Zahn et al. AGEMAP
28
-
4.33E-55
2.42E-57
-
Harries et al. 2012
Park et al. 2013
Harries et al. 2012
218
86
108
-
8.85E-18
1.25E-42
3.06E-36
6.51E-29
1.41E-28
3.43E-28
-
Passtoors et al. 2012
60
-
7.07E-63
2.85E-24
-
Newman & Murabito 2013
Harries et al. 2012
Chou et al. 2013
96
573
127
-
1.98E-47
2.80E-07
1.69E-45
2.15E-22
2.45E-21
6.84E-19
+
Luo et al. 2013
382
+
8.88E-16
2.40E-18
+
Zahn et al. AGEMAP
319
-
2.15E-20
4.87E-18
-
Chou et al. 2013
Houtkooper et al. 2013
297
840
480
+
-
3.63E-23
8.64E-07
7.13E-15
3.37E-17
1.12E-15
2.94E-15
+
Zahn et al. AGEMAP
383
+
2.47E-19
6.19E-15
+
+
+
?
+
+
Harries et al. 2012
Yu et al. 1996
Harries et al. 2012
de Magalhaes/Church
Harries et al. 2012
Harries et al. 2012
Harries et al. 2012
Harries et al. 2012
485
894
544
641
820
1128
794
866
1219
1025
987
940
1257
1257
1492
na
na
na
na
na
na
na
na
na
+
+
+
+
+
+
+
+
6.59E-16
9.41E-08
2.32E-16
2.38E-13
6.65E-11
1.26E-07
1.41E-13
1.57E-12
2.95E-08
1.93E-12
5.88E-14
4.66E-16
2.60E-10
2.60E-10
1.44E-06
4.41E-09
1.12E-06
1.88E-08
1.36E-06
2.70E-06
4.67E-08
3.48E-11
1.72E-06
1.84E-11
3.60E-14
2.43E-13
4.66E-12
8.81E-12
3.98E-11
7.75E-10
2.34E-09
7.63E-09
4.28E-08
7.00E-07
2.38E-06
4.82E-06
5.62E-06
5.62E-06
1.91E-05
9.99E-05
1.33E-04
5.54E-04
2.18E-03
2.26E-03
2.83E-02
3.10E-02
4.06E-02
1.06E-01
-
Zahn et al. AGEMAP
na
-
9.69E-07
3.42E-01
+
Baker et al. 2008
na
+
7.89E-07
7.45E-01
23
Supplementary Table 9: The candidate genes not carried forward to replication.
GENEID
Lookup
GENEID
ADARB2
ADIPOQ
AKT1
ANXA3
ADARB2
ADIPOQ
AKT1
ANXA3
ARPP19
ARPP19
ASF1A
ATP5G3
ASF1A
ATP5G3
ATP5J
ATP5J
BANF1
BLM
BRCA1
C1QA
C3
CAT
CETP
BANF1
BLM
BRCA1
C1QA
C3
CAT
CETP
CPSF5
NUDT21
CTSH
CTSS
CTSH
CTSS
CXCR4
CXCR4
EIF4E
EIF4EBP1
ERCC8
FOXO4
GIP
HIF1A
IGF1R
INSR
LKB1
EIF4E
EIF4EBP1
ERCC8
FOXO4
C1QTNF1
HIF1A
IGF1R
INSR
STK11
MDH1
MDH1
MGST1
MRE11
MGST1
MRE11A
MRE11A
MRE11A
MRP63
MRPL1
MRPL10
MRPL11
MRPL12
MRPL13
MRPL14
MRPL15
MRPL16
MRPL17
MRPL18
MRPL19
MRPL2
MRPL20
MRP63
MRPL1
MRPL10
MRPL11
MRPL12
MRPL13
MRPL14
MRPL15
MRPL16
MRPL17
MRPL18
MRPL19
MRPL2
MRPL20
Reason
Citation(s)
RANK
Longevity genetics or biology candidate
Downregulated in mice and humans w/ageing in multitissue analyses
Age and longevity expression association
Nestor-Guillermo Progeria syndrome
DNA repair genes
DNA repair genes
Upregulated in mice and humans w/ageing in multi-tissue
analyses
MTOR/FOXO pathways
MTOR/FOXO pathways
Cockayne syndrome
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
DNA repair genes
Barzilai & Gabriely 2010
3984
9016
5162
4022
Zahn et al. AGEMAP
10836
Passtoors et al. 2012
2844
9622
Zahn et al. AGEMAP
6638
Mendelian ageing disorder
Key DNA repair gene
Key DNA repair gene
4363
5492
6096
11600
2901
10608
1591
Zahn et al. AGEMAP
3232
2380
2308
Zahn et al. AGEMAP
6812
Harries et al. 2012
Harries et al. 2012
Mendelian ageing disorder
Harries et al. 2012
Sebastiani
Harries et al. 2012
Kenyon 2011
Harries et al. 2012
Harries et al. 2012
2644
4534
6625
5304
10428
8798
2770
6856
10505
Zahn et al. AGEMAP
4275
Key DNA repair gene
2724
3888
Zahn et al. AGEMAP
3888
8838
3705
5773
10556
4716
6335
10108
7351
7019
9959
4032
8375
4326
NA
24
MRPL21
MRPL22
MRPL23
MRPL27
MRPL28
MRPL30
MRPL32
MRPL33
MRPL34
MRPL37
MRPL38
MRPL39
MRPL4
MRPL40
MRPL41
MRPL42
MRPL42P5
MRPL43
MRPL44
MRPL47
MRPL48
MRPL49
MRPL50
MRPL51
MRPL52
MRPL53
MRPL54
MRPL55
MRPL9
MRPS10
MRPS11
MRPS12
MRPS14
MRPS15
MRPS16
MRPS17
MRPS18A
MRPS18C
MRPS2
MRPS21
MRPS22
MRPS23
MRPS24
MRPS25
MRPS28
MRPS30
MRPS34
MRPS35
MRPS36
MRPS5
MRPS7
MTOR
NBS
MRPL21
MRPL22
MRPL23
MRPL27
MRPL28
MRPL30
MRPL32
MRPL33
MRPL34
MRPL37
MRPL38
MRPL39
MRPL4
MRPL40
MRPL41
MRPL42
MRPL42P5
MRPL43
MRPL44
MRPL47
MRPL48
MRPL49
MRPL50
MRPL51
MRPL52
MRPL53
MRPL54
MRPL55
MRPL9
MRPS10
MRPS11
MRPS12
MRPS14
MRPS15
MRPS16
MRPS17
MRPS18A
MRPS18C
MRPS2
MRPS21
MRPS22
MRPS23
MRPS24
MRPS25
MRPS28
MRPS30
MRPS34
MRPS35
MRPS36
MRPS5
MRPS7
FRAP1
NBN
DNA repair genes
Kenyon
Key DNA repair gene
5971
9371
7774
10148
6173
10371
4652
9970
6884
5757
5668
2928
4356
9138
9523
4092
NA
4233
7459
7448
7343
6545
3825
7197
5007
11385
10444
3480
5619
5784
8418
9451
10388
11684
11549
2958
8305
10829
2409
3928
10766
8491
5522
2774
3085
6375
7406
2413
11533
8330
8289
7925
4173
25
NDRG1
NDUFB11
NDRG1
NDUFB11
OAT
OAT
PDK1
PI3K
PDK1
PIK3CA
PRDX6
PRDX6
PTEN
RHEB
PTEN
RHEB
RPL10
NOV
RPL37
RPL37
S100A4
S100A6
SESN3
SGK1
SIRT1
SIRT2
S100A4
S100A6
SESN3
SGK
SIRT1
SIRT2
SLC25A5
SLC25A5
SNX3
SNX3
SOD1
SOD2
TEK
TFRC
TSC1
TSC2
ULK1
UQCRFS1
UQCRQ
SOD1
SOD2
TEK
TFRC
TSC1
TSC2
ULK1
UQCRFS1
UQCRQ
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
analyses
MTOR/FOXO pathways
MTOR/FOXO pathways
analyses
analyses
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
MTOR/FOXO pathways
Harries et al. 2012
2646
4732
Zahn et al. AGEMAP
9865
Harries et al. 2012
Harries et al. 2012
4215
7589
Zahn et al. AGEMAP
5361
Harries et al. 2012
Harries et al. 2012
7324
10143
Zahn et al. AGEMAP
2064
Zahn et al. AGEMAP
NA
Harries et al. 2012
Harries et al. 2012
NA
3393
5719
3855
3309
2478
Zahn et al. AGEMAP
NA
Zahn et al. AGEMAP
10058
Sebastiani
Harries et al. 2012
Harries et al. 2012
Harries et al. 2012
4099
2262
5648
6258
5045
11259
4350
11681
5502
26
Supplementary Table 10. The mean (absolute) transcriptomic Δage per cohort, plus the number of samples, females, and smokers.
# samples
# females (%)
# smokers (%)
Mean Δage
(years)
RS
829
446 (53.8)
226 (27.3)
0.00
6.06
InCHIANTI
681
370 (54.3)
73 (10.7)
0.00
11.21
NIDDK/PHOENIX
1,457
717 (49.2)
NA
0.00
9.05
FHS-GEN2 (OFFSPRING)
2,446
1,343 (54.9)
205 (8.4)
0.00
7.31
SHIP-TREND
970
546 (56.3)
214 (22.1)
0.00
8.63
KORA
989
493 (49.9)
66 (6.7)
0.00
4.84
EGCUT
962
482 (50.1)
243 (25.3)
0.00
9.12
DILGOM
513
276 (53.8)
100 (19.5)
0.00
7.15
8,847
4,673 (52.8)
1,127 (12.7)
0.00
7.84
COHORT
SUM
Mean abs
Δage (years)
27
Supplementary Table 11 – part 1. Associations of transcriptomic Δage with 12 ageing phenotypes in the cohorts RS, INCHIANTI, NIDDK?PHOENIX, and FHS-GEN2 adjusted for chronological age.
Phenotype of Interest
Sex: 0 = male, 1 = female
Systolic blood pressure: mmHg
Diastolic blood pressure: mmHg
Total cholesterol levels: mmol/L
HDL cholesterol levels: mmol/L
Fasting glucose levels: mmol/L
Body Mass Index: kg/m2
Waist Hip Ratio
Hand grip strength: kg
Renal function
Mini Mental State Exam Score
Current smoking: 0 = no, 1 = yes
Effect
-0.0020
0.5424
0.3526
0.0017
0.0012
0.0165
0.0706
0.0008
0.0135
0.0377
-0.0064
0.0057
RS
SE
0.0026
0.1221
0.0706
0.0058
0.0024
0.0057
0.0243
0.0004
0.0569
0.0842
0.0099
0.0023
P
4.32E-01
1.06E-05
7.77E-07
7.68E-01
6.02E-01
3.96E-03
3.72E-03
5.48E-02
8.12E-01
6.55E-01
5.23E-01
1.37E-02
n
829
572
572
691
691
826
829
819
556
827
817
829
Effect
-0.0019
0.1064
0.0338
0.4370
0.1021
0.0058
0.0104
0.0001
0.0295
0.0925
-0.0183
-0.0008
INCHIANTI
SE
P
0.0015
2.12E-01
0.0585
6.96E-02
0.0329
3.05E-01
0.1208
3.20E-04
0.0465
2.85E-02
0.0041
1.52E-01
0.0132
4.31E-01
0.0002
7.57E-01
0.0312
3.44E-01
0.0614
1.32E-01
0.0147
2.12E-01
0.0009
4.13E-01
n
681
679
679
681
681
681
681
591
673
674
675
681
Effect
0.0007
0.2110
0.1330
0.0065
0.0050
0.0314
0.0081
na
na
0.0751
na
na
NIDDK/PHOENIX
SE
P
0.0013
6.07E-01
0.0377
2.59E-08
0.0259
3.19E-07
0.0030
2.71E-02
0.0010
1.73E-06
0.0081
1.05E-04
0.0190
6.72E-01
na
na
na
na
0.0453
9.80E-02
na
na
na
na
n
1,457
1,457
1,457
1,447
1,447
1,430
1,450
na
na
1,445
na
na
FHS-GEN2 (OFFSPRING)
Effect
SE
P
-0.0049
0.0013
1.14E-04
0.2267
0.042
8.48E-08
0.0706
0.025
4.84E-03
0.3251
0.095
6.21E-04
0.1336
0.046
3.58E-03
0.1941
0.061
1.51E-03
0.0462
0.014
8.05E-04
na
na
na
-0.0701
0.028
1.36E-02
-0.0424
0.045
3.47E-01
na
na
na
0.0033
0.0007
3.19E-06
n
2,440
2,438
2,435
2,440
2,439
2,439
2,440
na
2,422
2,439
na
2,440
Supplementary Table 11 – part 2. Associations of transcriptomic Δage with 12 ageing phenotypes in the cohorts SHIP-TREND, KORA, EGCUT, and DILGOM - adjusted
for chronological age.
Systolic bloodpressure: mmHg
Diastolic bloodpressure: mmHg
Waist Hip Ratio
Renal function
Effect
-0.0001
0.2131
0.1316
0.0101
0.0016
0.0043
0.0335
0.0003
na
0.0573
na
0.0117
SHIP-TREND
SE
P
0.0016
9.63E-01
0.0514
3.62E-05
0.0313
2.90E-05
0.0033
2.23E-03
0.0012
1.73E-01
0.0019
2.30E-02
0.0143
1.89E-02
0.0003
2.44E-01
na
na
0.0616
3.52E-01
na
na
0.0012
2.14E-20
n
970
969
969
970
970
970
970
970
na
970
na
970
Effect
0.0007
0.2752
0.0187
-0.0031
-0.0018
0.4725
0.0804
0.0011
na
na
na
0.0025
KORA
SE
P
0.003
8.33E-01
0.127
3.03E-02
0.062
7.64E-01
0.007
6.38E-01
0.002
4.28E-01
0.149
1.56E-03
0.029
5.18E-03
0.001
2.52E-02
na
na
na
na
na
na
0.002
1.07E-01
n
984
983
983
984
984
984
984
984
na
na
na
984
Effect
-0.0021
0.0450
0.0404
0.0058
0.0006
Na
0.0031
0.0003
Na
-0.0382
Na
-0.0058
EGCUT
SE
P
0.001
1.55E-01
0.048
3.47E-01
0.031
1.89E-01
0.003
6.77E-02
0.001
6.77E-01
na
na
0.013
8.19E-01
0.000
2.65E-01
na
na
0.052
4.65E-01
na
na
0.001
7.33E-06
n
962
962
962
962
962
na
962
962
na
962
na
962
Effect
0.0006
0.2227
0.1236
0.0028
-0.0009
na
0.0530
0.0006
na
na
na
-0.0005
DILGOM
SE
P
0.0025
8.05E-01
0.0884
1.21E-02
0.0504
1.46E-02
0.0048
5.60E-01
0.0019
6.22E-01
na
na
0.0228
2.06E-02
0.0004
1.63E-01
na
na
na
na
na
na
0.0020
7.86E-01
n
513
511
511
513
513
na
513
511
na
na
na
513
We tested whether the transcriptomic delta age was associated with twelve different phenotypes known to be associated with chronological age. Gene expression levels were
adjusted for plate ID, RNA quality score, fasting state, sex, smoking status, and cell counts. Results are presented per cohort, and these results were the basis for Table 2,
which shows the results of the meta-analysis across all cohorts.
28
Supplementary Table 12 – part 1. Associations of transcriptomic Δage with 12 ageing phenotypes in the cohorts RS, INCHIANTI, NIDDK/PHOENIX, and FHS-GEN2 adjusted for chronological age and BMI.
Waist Hip Ratio
Renal function
Effect
-0.0019
0.5120
0.3230
0.0020
0.0030
0.0107
na
0.0003
0.0134
0.0418
-0.0064
0.0063
RS
SE
0.0026
0.1219
0.0697
0.0058
0.0023
0.0054
na
0.0004
0.0571
0.0847
0.0100
0.0023
P
4.60E-01
3.11E-05
4.41E-06
7.28E-01
1.89E-01
4.75E-02
na
4.30E-01
8.14E-01
6.22E-01
5.21E-01
6.40E-03
n
829
572
572
691
691
826
na
819
556
827
817
829
Effect
-0.0018
0.1007
0.0276
0.4334
0.1129
0.0052
na
0.0001
0.0253
0.0720
-0.0197
-0.0007
INCHIANTI
SE
P
0.0015
2.33E-01
0.0582
8.37E-02
0.0320
3.90E-01
0.1209
3.61E-04
0.0445
1.15E-02
0.0040
1.91E-01
na
na
0.0002
7.26E-01
0.0308
4.12E-01
0.0494
1.45E-01
0.0146
1.78E-01
0.0009
4.34E-01
n
681
679
679
681
681
681
na
591
673
674
675
681
Effect
0.0006
0.2100
0.1310
0.0067
0.0051
0.0311
na
na
na
0.0757
na
na
NIDDK/PHOENIX
SE
P
0.001
6.30E-01
0.038
2.38E-08
0.026
4.13E-07
0.003
2.42E-02
0.001
4.03E-07
0.008
1.06E-04
na
na
na
na
na
na
0.045
9.53E-02
na
na
na
na
n
1,450
1,450
1,450
1,440
1,440
1,423
na
na
na
1,438
na
na
FHIS-GEN2 (OFFSPRING)
Effect
SE
P
-0.0054
0.0013
2.18E-05
0.2120
0.042
5.03E-07
0.0645
0.025
9.94E-03
0.3699
0.094
8.79E-05
0.1872
0.043
1.42E-05
0.1453
0.059
1.46E-02
na
na
na
na
na
na
-0.0769
0.028
6.77E-03
-0.0430
0.045
3.42E-01
na
na
na
0.0034
0.0007
1.19E-06
n
2,440
2,438
2,435
2,440
2,439
2,439
na
na
2,422
2,439
na
2,440
Supplementary Table 12 – part 2. Associations of transcriptomic Δage with 12 ageing phenotypes in the cohorts SHIP-TREND, KORA, EGCUT, and DILGOM - adjusted
for chronological age and BMI.
Waist Hip Ratio
Renal function
Effect
0.0003
0.1834
0.1068
0.0096
0.0027
0.0031
na
0.0001
na
0.0710
na
0.0117
SHIP-TREND
SE
P
0.0016
8.58E-01
0.0498
2.45E-04
0.0295
3.04E-04
0.0033
3.77E-03
0.0011
1.62E-02
0.0018
9.10E-02
na
na
0.0003
8.04E-01
na
na
0.0615
2.49E-01
na
na
0.0012
2.75E-20
n
970
969
969
970
970
970
na
970
na
970
na
970
Effect
0.0000
0.2732
0.0173
-0.0018
-0.0001
0.3707
na
0.0008
na
na
na
0.0029
KORA
SE
P
0.003
9.99E-01
0.127
3.23E-02
0.063
7.83E-01
0.007
7.79E-01
0.002
9.78E-01
0.145
1.08E-02
na
na
0.000
1.23E-01
na
na
na
na
na
na
0.002
6.57E-02
n
984
983
983
984
984
984
na
984
na
na
na
984
Effect
-0.0021
0.0412
0.0378
0.0057
0.0007
na
na
0.0003
na
-0.0375
na
-0.0058
EGCUT
SE
P
0.001
1.60E-01
0.045
3.58E-01
0.029
1.86E-01
0.003
7.00E-02
0.001
5.97E-01
na
na
na
na
0.000
2.52E-01
na
na
0.052
4.73E-01
na
na
0.001
7.45E-06
n
962
962
962
962
962
na
na
962
na
962
na
962
Effect
0.0007
0.1934
0.1030
0.0019
0.0003
na
na
0.0002
na
na
na
-0.0005
DILGOM
SE
P
0.0026
7.72E-01
0.0880
2.85E-02
0.0500
3.97E-02
0.0048
7.01E-01
0.0018
8.58E-01
na
na
na
na
0.0004
5.96E-01
na
na
na
na
na
na
0.0020
8.23E-01
n
513
511
511
513
513
na
na
511
na
na
na
513
We tested whether the transcriptomic delta age was associated with twelve different phenotypes known to be associated with chronological age. Gene expression levels were
adjusted for plate ID, RNA quality score, fasting state, sex, smoking status, and cell counts. Results are presented per cohort, and these results were the basis for Table 2,
which shows the results of the meta-analysis across all cohorts.
29
Supplementary Table 13. Association of transcriptomic Δage (green), Horvath’s epigenetic Δage (red), and Hannum’s epigenetic Δage (blue) with ageing phenotypes –
adjusted for chronological age, sex, and BMI.
n
TC-Effect
TC-SE
TC-P
Dir
HO-Effect
HO-SE
HO-P
Dir
HA-Effect
HA-SE
HA-P
Dir
Systolic bloodpressure: SBP (mmHg)
1,197
0.306
0.095
1.30E-03
++
-0.012
0.080
8.80E-01
-+
0.087
0.103
4.02E-01
++
Diastolic bloodpressure: DBP (mmHg)
1,197
0.104
0.051
4.32E-02
+-
-0.059
0.042
1.61E-01
--
-0.028
0.055
6.15E-01
+-
Total cholesterol levels: TC (mmol/L)
1,286
-0.001
0.005
8.71E-01
+-
-0.002
0.004
6.19E-01
--
-0.010
0.005
6.26E-02
--
HDL cholesterol levels: HDL (mmol/L)
1,286
0.003
0.002
1.25E-01
++
-0.002
0.001
1.04E-01
--
-0.003
0.002
1.15E-01
+-
Fasting glucose levels: FG (mmol/L)
1,394
0.011
0.006
5.30E-02
++
-0.003
0.005
5.42E-01
-+
0.013
0.006
3.49E-02
++
WHR
1,388
0.001
0.000
2.13E-02
++
0.001
<0.001
1.33E-02
++
0.001
<0.001
2.51E-03
++
1,396
0.005
0.002
7.92E-04
++
0.001
0.001
3.71E-01
++
0.004
0.002
5.87E-03
++
Gene expression levels were adjusted for plate ID, RNA quality score, fasting state, sex, smoking status, and cell counts. TC = transcriptomic predictor, HO = Horvath
predictor, HA = Hannum predictor, Dir = direction of the effect, n = sample size of the meta-analysis, EV = explained variance, RS = Rotterdam Study, KORA = The KORA
Study, BMI = Body mass index, WHR = Waist-hip-ratio.
Supplementary Table 14. The explained variance using the transcriptomic predictor (green), the Horvath’s epigenetic predictor (red), and the Hannum’s epigenetic predictor
(blue) of the ageing phenotypes – adjusted for chronological age, sex, and BMI
n
TC-EV-RS
TC-EV-KORA
HO-EV-RS
HO-EV-KORA
HA-EV-RS
HA-EV-KORA
1,197
0.022
0.001
0.000
0.000
0.000
0.000
1,197
0.033
0.000
0.000
0.000
0.000
0.000
1,286
0.000
0.001
0.000
0.000
0.002
0.001
1,286
0.000
0.000
0.000
0.005
0.000
0.012
1,394
0.007
0.007
0.000
0.007
0.007
0.003
WHR
1,388
0.004
0.015
0.002
0.005
0.012
0.006
1,396
0.010
0.003
0.002
0.000
0.009
0.001
predictor, HA = Hannum predictor, n = sample size of the meta-analysis, EV = explained variance, RS = Rotterdam Study, KORA = The KORA Study, BMI = Body mass
index, WHR = Waist-hip-ratio.
30
Supplementary Table 15. Combining the transcriptomic Δage and Horvath’s epigenetic Δage in one model – associations of both predictors with the ageing phenotypes adjusted for chronological age, sex, and BMI
n
TC-Effect
TC-SE
TC-P
Dir
HO-Effect
HO-SE
HO-P
Dir
EV-RS
EV-KORA
1,197
0.320
0.097
9.31E-04
++
-0.059
0.080
4.66E-01
-+
0.023
0.000
1,197
0.121
0.052
2.01E-02
+-
-0.076
0.043
7.48E-02
--
0.038
0.000
1,286
<0.001
0.005
9.54E-01
+-
-0.002
0.004
6.27E-01
-+
0.000
0.000
1,286
0.003
0.002
6.87E-02
++
-0.003
0.001
5.02E-02
--
0.000
0.004
1,394
0.012
0.006
3.24E-02
++
-0.006
0.005
2.81E-01
-+
0.008
0.012
WHR
1,388
<0.001
<0.001
5.91E-02
++
<0.001
<0.001
3.68E-02
++
0.004
0.017
1,396
0.005
0.002
1.45E-03
++
0.000
0.001
7.80E-01
+-
0.010
0.001
predictor, n = sample size of the meta-analysis, EV = explained variance, RS = Rotterdam Study, KORA = The KORA Study, BMI = Body mass index, WHR = Waist-hipratio.
Supplementary Table 16. Combining the transcriptomic Δage and Hannum’s epigenetic Δage in one model – associations of both predictors with the ageing phenotypes adjusted for chronological age, sex, and BMI
n
TC-Effect
TC-SE
TC-P
Dir
HA-Effect
HA-SE
HA-P
Dir
EV-RS
EV-KORA
1,197
0.309
0.100
1.89E-03
++
-0.003
0.107
9.76E-01
-+
0.020
0.000
1,197
0.123
0.054
2.17E-02
+-
-0.056
0.058
3.29E-01
--
0.032
0.000
1,286
0.002
0.005
6.74E-01
+-
-0.010
0.005
6.36E-02
--
0.003
0.001
1,286
0.004
0.002
3.23E-02
++
-0.004
0.002
3.54E-02
--
0.000
0.011
1,394
0.008
0.006
1.50E-01
++
0.011
0.006
9.63E-02
++
0.011
0.007
WHR
1,388
<0.001
<0.001
1.34E-01
++
0.001
<0.001
1.62E-02
++
0.012
0.016
1,396
0.004
0.002
7.34E-03
++
0.003
0.002
6.00E-02
++
0.015
0.002
Gene expression levels were adjusted for plate ID, RNA quality score, fasting state, sex, smoking status, and cell counts. TC = transcriptomic predictor, HA = Hannum
predictor, n = sample size of the meta-analysis, EV = explained variance, RS = Rotterdam Study, KORA = The KORA Study, BMI = Body mass index, WHR = Waist-hipratio.
31
Supplementary Table 17. Description of the discovery cohorts.
Discovery Cohort
Sample size
Primary ancestry
Cell type
Age (mean)
Fasting
Type of Cohort
Covariates Included
EGCUT
1,086
European
Whole blood
38.2
Y
Population-Based
cell counts, plateID, RQS, sex, smoking status, fasting status
FHS - OFFSPRING
(GEN 2: EXAM 8)
2,608
European-American
Whole blood
66.4
Y
Family-Based
plateID, RQS, sex, smoking status, fasting status, family design
INCHIANTI
698
European
Whole blood
72.2
N
Population-Based
cell counts, plateID, sex, smoking status
KORA
993
European
Whole blood
70.4
Y
Population-Based
#platelets, plateID, RQS, sex, smoking status, fasting status
RS-III
881
European
Whole blood
59.8
Y
Population-Based
SHIP-TREND
991
European
Whole blood
50.2
Y
Population-Based
The sample size, the primary ancestry, the cell type, the mean age, the fasting status, the type of cohort, and the covariates used in the linear regression analysis.
Supplementary Table 18. Description of the replication cohorts.
Replication Cohort
Sample size
Primary ancestry
Cell type
Age (mean)
Fasting
BSGS
962
European-Australian
Whole blood
20.1 (bi-model distribution)
DILGOM
512
European
Whole blood
51.5
FEHRMANN
1,191
European
Whole blood
62.8
N
FHS - GEN 3
(GEN 3: EXAM 2)
3,180
European-American
Whole blood
46.4
Y
Family-Based
cellcounts, plateID, RQS, sex, smoking status,
fasting status, family design
GTP
359
African-American
Whole blood
42.5
Y
Population-Based
plateID, array version, sex, RQS
HVHv3
121
European-American
Whole blood
68.4
N
MI/STROKE/AF cases & controls
cellcounts, plateID, RQS, sex
227
European-American
Whole blood
68.7
N
MI/STROKE/AF cases & controls
cellcounts, plateID, RQS, sex
1,457
Native American
Whole blood
35.9
Y
Population-Based
plateID, sex
HVHv4
NIDDK/PHOENIX
Type of Cohort
Covariates Included
Y
Family-Based
cellcounts, plateID, RQS, sex, fasting status
Y
Population-Based
COPD/ALS
cases & controls
sex, fasting status
Sex
32
Supplementary Table 19. Description of the generalization cohorts.
Generalization Cohort
BOSTON COHORT-CD4+
Sample size
Primary ancestry
Cell type
Age (mean)
Fasting
Type of Cohort
213
Multi-ethnic
CD4+ cells
28.4
na
Population-Based
EGCUT-CD4+
302
European
CD4+ cells
53.1
na
Population-Based
EGCUT-CD8+
299
European
CD8+ cells
52.6
na
Population-Based
BOSTON COHORT-CD14+
213
Multi-ethnic
CD14+ cells
28.4
na
Population-Based
MESA-MONOCYTES
354
Multi-ethnic
Monocytes
70.2
na
NABEC-UKBEC-CB
394
European
Cerebellum
51.3
na
NABEC-UKBEC-FC
394
European
Frontal cortex
51.3
na
GENOA-LCLs
869
Multi-ethnic
LCLs
59.0
na
SAFS-LYMPHOCYTES
Covariates Included
sex
plateID, sex, smoking status, amount of RNA per
sample
plateID, sex, smoking status, amount of RNA per
sample
sex
Autopsy brain samples: no
recognisable neurological disease
Autopsy brain samples: no
recognisable neurological disease
cellcounts, plateID, RQS, smoking status, fasting
status
batch, sex, postmortem interval, 2 Principal
Components
batch, sex, postmortem interval, 2 Principal
Components
Hypertension Siblings
plateID, RQS, sex, smoking status
Atherosclerosis cases & controls
1,244
Hispanic
Lymphocytes
39.3
Y
Family-Based
sex, family design
GARP-PBMCs
134
European
PBMC
60.1
N
Osteoarthritis cases & controls
plateID, sex, smoking status, fasting status
PBMC-MS
228
Multi-ethnic
PBMC
40.9
N
MS cases & controls: treated with
IFN-b, glatiramer acetate or
untreated
sex
33
Supplementary Table 20. Direct associations between chronological age and the ageing phenotypes.
META-ANALYIS
Zscore
P
Direction
n
0.585
5.59E-01
++-++-+-
8,836
27.317
2.66E-164
++++++++
8,571
-1.605
1.08E-01
+-+-+-++
8,568
5.491
3.99E-08
+-+-+-++
8,688
-1.247
2.12E-01
+-+-----
8,687
13.292
2.58E-40
++++++??
7,330
8.238
1.75E-16
+++-++++
8,829
Waist Hip Ratio
15.490
4.05E-54
++??++++
4,837
-23.141
1.79E-118
--?-????
3,651
Renal function
-42.159
2.14e-388
-----?-?
7,317
-13.397
6.32E-41
--??????
1,492
-11.587
4.81E-31
--?---+-
7,379
We tested whether chronological age was associated with the twelve phenotypes known to be associated with chronological age. Gene expression levels were adjusted for
plate ID, RNA quality score, fasting state, sex, smoking status, and cell counts. Results were meta-analyzed over all cohorts.
34
Supplementary Table 21. Calculation of mean age and the pooled variance over all samples in the meta-analysis.
COHORT
MEAN AGE
SD AGE
s2 (variance)
n
n-1
(n-1)*s2
DILGOM
51.90
13.70
187.69
512
511
95909.59
EGCUT
38.22
15.76
248.38
1,086
1,085
269489.70
FHS-OFFSPRING
66.40
8.95
80.10
2,446
2,445
195850.61
INCHIANTI
72.23
15.27
233.17
695
694
161821.99
KORA
70.38
5.37
28.79
993
992
28563.60
NIDDK/PHOENIX
35.90
12.30
151.29
1,457
1,456
220278.24
RS
59.80
8.10
65.61
875
874
57343.14
SHIP-TREND
50.59
13.72
188.35
991
990
186464.69
MEAN AGE
55.81
POOLED s2(VARIANCE)
134.38
POOLED SD
11.59
We calculated the pooled variance using the mean age, the standard deviation, and the sample size, as described on http://en.wikipedia.org/wiki/Pooled_variance
35
SUPPLEMENTARY NOTE 1
Descriptions of the participating study populations
Brisbane Systems Genetics Study (BSGS)
Individuals present in this study were recruited as part of the Brisbane Twin Nevus and cognition
studies (known as BTN and MAPS respectively). As described in detail elsewhere1, adolescent MZ and DZ
twins, their siblings, and their parents have been recruited over a 16 year period into an ongoing study of the
genetic and environmental factors influencing pigmented nevi and the associated risk of developing skin
cancer and cognition. The sample is of northern European origin (mainly Anglo-Celtic). A Principal
Component Analysis (PCA) comparing individuals in this study to HapMap3 (International HapMap3
Consortium) and GenomEUtwin2 populations shows the close similarity of ancestry to northern European
populations. All participants gave informed consent, and the appropriate institutional review boards approved
the study protocol. Whole blood for expression profiling was collected directly into PAXGene ™ tube
(QIAGEN, Valencia, CA). Total RNA was extracted from PAXGene™ tubes using the WB gene RNA
purification kit (QIAGEN, Valencia, CA). RNA from all samples was run on an Agilent Bioanalyzer to assess
quality and to estimate RNA concentrations RNA was converted to cDNA, amplified and purified using the
Ambion Illumina TotalPrep RNA Amplification Kit (Ambion).
Expression profiles were generated by hybridising 750 ng of cRNA to Illumina HumanHT-12 v4.0
Beadchip according to Illumina whole-genome gene expression direct hybridization assay guide (Illumina Inc,
San Diego, USA). Briefly, 500 ng of total RNA were used to generate biotinylated cRNA, which was
fragmented and hybridised to an Illumina whole genome expression chip, HumanHT-12 v4.0 for 18 h at 58°C.
Beadchips were then washed and stained and subsequently scanned to obtain fluorescence intensities. Samples
were scanned using an Illumina Bead Array Reader. Samples were randomized across chips and chip
positions, with checks for balance across families, sex and generation. Full details of the BSGS cohort and
sample preparation are given elsewhere3,4. The expression data is available at GEO (Gene Expression
Omnibus) public repository under the accession GSE33321.
DNA methylation was measured on 614 individuals from 117 families of European descent
recruited as part of BSGS5. Bisulfite conversions were performed in 96 well plates using the EZ-96 DNA
Methylation Kit (Zymo Research, Irvine, CA, USA). Prior to conversion, DNA concentrations were
determined by NanoDrop quantification (NanoDrop Technologies, Inc., Wilmington, DE, USA) and
standardised to include 500ng. Three technical replicates were included in each conversion to assess
repeatability. A commercial female human genomic DNA sample (Promega Corporation, Madison, WI, USA)
was used on all plates, one sample from each run was duplicated on the plate and one sample duplicated from
a different plate. DNA recovery after conversion was quantified using Nanodrop (Thermo Scientific,
Wilmington, DE, USA).
Bisulfite converted DNA samples were hybridised to the 12 sample, Illumina
HumanMethylation450 BeadChips using the Infinium HD Methylation protocol and Tecan robotics (Illumina,
San Diego, CA, USA). The HM 450 BeadChip-assessed methylation status was interrogated at 485,577 CpG
sites across the genome. It provides coverage of 99% of RefSeq genes. Methylation scores for each CpG site
are obtained as a ratio of the intensities of fluorescent signals and are represented as β-values. Samples were
randomly placed with respect to the chip they were measured on and to the position on that chip in order to
avoid any confounding with family. Box-plots of the red and green intensity levels and their ratio were used to
ensure that no chip position was under- or over-exposed, with any outlying samples repeated. Similarly, the
proportion of probes with detection p-value less than 0.01 was examined to confirm strong binding of the
sample to the array.
Methylation probes on the sex chromosomes or having been annotated as binding to multiple
chromosomes were removed from the analysis, as were those with zero CpG sites. The probability of a probe
within a sample either being called as missing or with a detection p-value less than 0.001 were estimated from
the average rate across all probes and samples. A threshold for probes showing significant deviation from
random missingness (or excess poor binding) was determined by testing against a binomial distribution for the
number of samples at the 0.05 significance level with a Bonferroni correction for the number of probes. Any
probe with more than 11 individuals with missing data or more than five individuals with detection p-values >
36
0.001 were removed. After cleaning a total of 417,069 probes remained.
Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome study (DILGOM)
The Finnish study samples included a total of 513 unrelated individuals aged 25–74 years from the
Helsinki area, recruited during 2007 as part of the DILGOM study, an extension of the FINRISK 2007 study
described earlier6. Study participants were asked to fast overnight (at least 10 hours) prior to giving a blood
sample.
To obtain stabilized total RNA, we used the PAXGene Blood RNA System (PreAnalytiX GMbH,
Hombrechtikon, Switzerland). It included collection of 2.5 ml peripheral blood into PAXGene Blood RNA
Tubes (Becton Dickinson and Co., Franklin Lakes, NJ, USA) and total RNA extraction with PAXGene Blood
RNA Kit (Qiagen GmbH, Hilden, Germany). Protocol recommended by the manufacturer was used. The
integrity and quantity of the RNA samples were evaluated with the 2100 Bioanalyzer (Agilent Technologies,
Santa Clara, CA, USA). Biotinylated cRNA was produced from 200 ng of total RNA with Ambion Illumina
TotalPrep RNA Amplification Kit (Applied Biosystems, Foster City, CA, USA), using the protocol specified
by the manufacturer. 750 ng of biotinylated cRNA were hybridized onto Illumina HumanHT-12v3 Expression
BeadChips (Illumina Inc., San Diego, CA, USA), using standard protocol. After sample mix-up correction,
509 samples were included for further analysis in this cohort. The expression data is available at ArrayExpress
public repository under the accession E-TABM-1036.
Estonian Gene Expression Cohort (EGCUT)
The Estonian Gene Expression Cohort is composed of 1,124 randomly selected samples (mean age
37.8 years) from the Estonian Genome Center, University of Tartu (EGCUT, www.biobank.ee). The EGCUT
is the population based database which comprises currently the health, genealogical and genome data of more
than 51,530 individuals 18 years of age and up reflecting closely the age distribution in the adult Estonian
population. Participants of EGCUT recruited by the general practitioners (GP) from GP offices, physicians
from the hospitals or data collectors from EGCUT’s patient recruitment offices. Each participant filled out a
Computer Assisted Personal interview during 1-2 hours at a doctor’s or data collector’s office, including
personal data (place of birth, place(s) of living, nationality etc.), genealogical data (family history, three
generations), educational and occupational history and lifestyle data (physical activity, dietary habits,
smoking, alcohol consumption, quality of life). Anthropometric and physiological measurements were also
taken. All diseases are defined according to the ICD10 coding. Women filled out additional questionnaire
relating to the woman’s health.
The collection of blood samples and the data is conducted according to the Estonian Gene Research
Act and all participants have signed the broad informed consent. For gene expression profiling, whole blood
samples were collected in Tempus Blood RNA Tubes (Life Technologies, NY, USA). RNA was extracted
using Tempus Spin RNA Isolation Kit (Life Technologies, NY, USA) and quantified by NanoDrop 1000
Spectrophotometer (Thermo Fisher Scientific, DE, USA). RNA integrity was assessed by Agilent 2100
Bioanalyzer (Agilent Technologies, CA, USA). Samples with RIN<7.0 were excluded. Following
amplification and labelling of RNA by Ambion TotalPrep RNA Amplification Kit (Life Technologies, NY,
US), the whole genome gene expression levels were obtained by Illumina HT12v3 arrays (Illumina Inc, San
Diego, US) according manufactures protocols. 1,086 samples passed the general quality control and were
included in the subsequent analyses. The expression data is available at GEO (Gene Expression Omnibus)
public repository under the accession GSE48348.
Methylation data pre-processing and quality control analyses were performed in R using the
Bioconductor package minfi7 . ‘Raw’ pre-processing was used to convert the intensities from the red and the
green channels into methylated and unmethylated signals. Beta values were computed using Illumina’s
formula [beta = M/(M+U+100)]. The difference in the distribution of beta values for type I and type II probes
was corrected for using the SWAN normalization method8. Detection p-values were obtained for every CpG
probe in every sample. Failed positions were defined as signal levels lower than background from both the
methylated and unmethylated channels. Samples with high proportion of failed position were discarded from
further analyses.
For the purification of CD4+ and CD8+ T-cells, we obtained peripheral blood from healthy donors
of the Estonian Genome Center of the University of Tartu (Tserel et al., in press). Peripheral blood
37
mononuclear cells (PBMC) were extracted using Ficoll-Paque (GE Healthcare) gradient centrifugation. CD4+
T cells and CD8+ T cells were extracted from the PBMCs by consecutive positive separation using microbeads
(CD4+ #130-045-101; CD8+ #130-045-201) and AutoMACS technology (Miltenyi Biotec) according to the
manufacturer's protocol. RNA was extracted using the miRNeasy Mini Kit combined with a recommended
RNase-free DNase I treatment (both from Qiagen) according to the manufacturer’s protocol. The RNA was
labeled and amplified using the TargetAmp Nano Labeling Kit for Illumina Expression BeadChip (Epicentre
Biotechnologies) with SuperScript III Reverse Transcriptase (Life Technologies) according to the
manufacturer's protocol, followed by purification with the RNeasy MinElute Cleanup Kit (Qiagen). The
labelled RNA samples were hybridized to HumanHT-12 v4 Expression BeadChips (Illumina) according to the
manufacturer's instructions.
Fehrmann et al. dataset (FEHRMANN)
The Fehrmann dataset consists of whole peripheral blood samples of 1,469 unrelated individuals
from the United Kingdom and the Netherlands9,10. Some of these individuals are patients, while others are
healthy controls. RNA levels were quantified using both the Illumina H8v2 platform (229 samples) and the
HT12v3 platform (1,240 samples), as has been described before. The total number of samples having geneexpression data and age equals 1,191. The expression data is available at GEO (Gene Expression Omnibus)
public repository under the accessions GSE20332 and GSE20142.
Framingham Heart Study (FHS)
The Framingham Heart Study (FHS) is a community-based, prospective, longitudinal study of three
generations of participants. The original cohort enrolled 5,209 participants starting in 1948 and the Offspring
(Second Generation) cohort enrolled 5,124 children and spouses of children of the original cohort starting in
197111. From 2002 to 2005 the grandchildren of the original cohort were enrolled in the Third Generation
cohort. Participants gave informed consent for research and the study is approved by the Boston University
IRB. Participants received clinic visits examinations over time including detailed medical histories, standard
exam measurements and had fasting blood samples collected.
Fasting whole blood samples (PAXGene Tubes-Becton Dickinson) were collected from the FHS
OFFSPRING (at their 8th examination cycle), and the FHS 3rd GENERATION (at their 2nd examination cycle).
Details of the cohort designs and ascertainments have previously been described39. RNA was extracted from
whole blood samples following the manufacturers' protocol (PAXGene Blood RNA kit - Assuragen). 50 ng of
total RNA were amplified following the NuGen WG-Ovation Pico RNA amplification system and labeling
conducted with the FL-Ovation cDNA Biotin Module V2 (NuGen, San Carlos, CA). Fragmented, biotinylated
cDNA (5.5ug) was prepared for each sample and added to a hybridization cocktail and loaded onto an
Affymetrix Human Exon 1.0 ST GeneChip (1.4 million probesets), and hybridized at 450C and 60 rpm for
16h. The manufacturer's protocol was followed for washing and staining, and stained arrays were scanned at
532 nm in an Affymetrix GeneChip Scanner 3000 to generate CEL files for each array. The expression data is
available at dbGAP public repository under the accession phs000363.v7.p8.
Genetics, osteoARthritis and Progression (GARP)
The GARP study is a study among Dutch Caucasian sib pairs with symptomatic osteoarthritis at
multiple joint locations: the GARP study consists of 191 sib pairs (N=382) of white, Dutch, ancestry. All
participants (age-range: 40-70 years; mean age: 60 years) are clinically and radiographically diagnosed with
primary, symptomatic osteoarthritis at multiple joint sites in the hand, or in at least two joints of the following
locations: hand, spine, knee, or hip12.
For the current study, whole genome expression profiles were analyzed from 108 participants (68
unrelated families) of the GARP study and 26 age-matched healthy controls was used. Details on the
generation of expression profiles and analysis are described earlier13. In short, blood of participants was
collected and mononuclear blood cells were separated with Histopaque® gradient prior to RNA isolation.
After RNA isolation the quality of 36 random samples was analyzed. Samples had an RNA integrity number
(RIN) of 8.3 or higher, and an average 28S/18S ratio of 2.2 (range: 1.8-2.7). For cDNA synthesis,
amplification, biotin labeling, and hybridization with 500ng of total RNA the Ambion® TotalPrep™-96 RNA
amplification kit (Life Technologies) was used according to the manufacturer’s protocol. Samples were
38
hybridized onto the microarrays (Illumina Human HT-12_v3_BeadChip’s; Illumina). Quality control was
performed in the R statistical programming language using the lumi-package. Total number of samples
included in the current work is 134.
For the methylation analysis, genomic DNA was extracted with phenol-chloroform, and isolated
DNA was treated with sodium bisulphite using the ZymoResearch EZ DNA Methylation kit. DNA
methylation was assayed at over 450,000 sites on the Illumina Infinium HumanMethylation 450K BeadChips.
Quality control was performed in the R statistical programming language using the minfi- and methylumipackage. Total number of samples with data on expression and methylation included in the current work is
120. The expression data is available at GEO (Gene Expression Omnibus) public repository under the
accession GSE48556.
Genetic Epidemiology Network of Arteriopathy (GENOA)
The Genetic Epidemiology Network of Arteriopathy (GENOA) study consists of hypertensive
sibships that were recruited for linkage and association studies in order to identify genes that influence blood
pressure and its target organ damage14. In the initial phase of the GENOA study (Phase I: 1996-2001), all
members of sibships containing ≥ 2 individuals with essential hypertension clinically diagnosed before age 60
were invited to participate, including both hypertensive and normotensive siblings.
The GENOA gene expression cohort is composed of 883 European-American individuals
participating in the “Genetics of Microangiopathic Brain Injury” substudy, which investigates the genetic
basis of alteration in brain structure detectable by magnetic resonance imaging15.
RNA samples from cell lines established from peripheral blood samples by Epstein-Barr virus
transformation were extracted using standard protocols. RNA quality was assessed using the Agilent 2100
Bioanalyzer (Agilent Technologies Inc., Foster City, CA) and quantified by spectrophotometry using the
Nanodrop ND-1000 (Nanodrop Inc., Wilmington, DE). All RNA samples used in the present study yielded
both an A260/A280 absorbance ratio greater than 2.0 and a RNA Integrity Number (RIN) ≥ 8. One μg of
RNA was labeled using the WT Expression labeling assay (Applied Biosystems/ Ambion, Foster City, CA)
including the labeling controls from the GeneChip Eukaryotic Poly-A RNA Control Kit (Affymetrix, Santa
Clara, CA). Each step of the labeling protocol was monitored using the Agilent 2100 Bioanalyzer or the
Nanodrop spectrophotometer, as recommended by the manufacturer. Labeled cRNAs were hybridized onto
the Affymetrix Human Exon 1.0 ST Array.
Array quality control was performed using Affymetrix Expression Console™ (v 1.1) at the
transcript level using core-level probe sets. All array images passed visual inspection. Hybridization controls
were all present with signal increases following concentration. Labeling control signal strengths followed the
order Lys < Phe < Thr < Dap. Signal intensity plots were examined for raw and processed data to identify
outliers. Only core probesets were used to assess exon-level expression. Probe sets, which are known to crosshybridize and those with undetectable expression were also excluded. Transcript-level expression was
assessed by averaging all the core probe sets for that gene. QC metrics were again examined to identify
possible outliers or non-performing samples using the Partek Genomic Suite software (V.6.6). These included
the mean raw intensity for all probes, the distribution of RMA normalized intensities, and principal
component analysis. We also verified sex assignment of the samples by examining expression levels of genes
on the Y chromosome.
RNA quality control and microarray expression profiling experiments were conducted at the
laboratory of Dr. Myriam Fornage at the University of Texas Health Science Center at Houston. The
expression data is available at GEO (Gene Expression Omnibus) public repository under the accession
GSE49531.
Grady Trauma Project (GTP)
The Grady Trauma Project (GTP) is a population-based, prospective study of demographic
characteristics, trauma exposure, and prevalence of post-traumatic stress disorder and major depressive
disorder in an urban, predominantly African-American population16. Subjects were recruited prospectively
from the waiting rooms of primary care and obstetrics-gynecology clinics of Grady Memorial Hospital in
Atlanta, GA. Exclusion criteria included mental retardation, active psychosis, or the inability to give informed
consent. Written and verbal informed consent was obtained for all participating subjects. All procedures in
39
this study were approved by the Institutional Review Boards of Emory University School of Medicine and
Grady Memorial Hospital. Since its inception in 2005, over 5000 subjects have been interviewed for the study.
For the expression analysis, whole blood was collected between 8 - 9 a.m. in Tempus RNA tubes
for 398 subjects. All subjects were instructed to fast before blood collection. Whole genome expression
profiles were generated for 398 subjects at the Max-Planck Institute as follows: RNA was isolated using the
Versagene kit (Gentra Systems, Minneapolis, U.S.A.), quantified using the Nanophotometer and quality
checks were performed on the Agilent Bioanalyzer. 250 nanograms of total RNA were reverse transcribed to
cDNA, converted to cRNA and biotin-labeled using the Ambion kit (AMIL1791, Applied Biosystems), 750
nanograms of cRNA were hybridized to Illumina HT-12 v3.0 or v4.0 arrays (Illumina, San Diego, California,
U.S.A) and incubated overnight for 16 hours at 55ºC. Arrays were washed, stained with Cy3 labeled
streptavidin, dried and scanned on the Illumina BeadScan confocal laser scanner. 21,394 transcripts were on
both the v3.0 and v4.0 arrays and were significantly expressed above background levels (detection P<.05) in
at least 10% of subjects, and were thus eligible for further analysis. Of the initial 398 subjects, 359 subjects
with self-reported African-American ancestry were selected for this analysis. Age of subjects at blood draw
ranged from 16-78 years. The expression data is available at GEO (Gene Expression Omnibus) public
repository under the accession GSE58137.
For the methylation analysis, we extracted DNA from whole blood at the Max Planck Institute in
Munich using the Gentra Puregene Kit (Qiagen). Genomic DNA was then bisulfite converted using the Zymo
EZ-96 DNA Methylation Kit (Zymo Research). We assessed DNA methylation at >480,000 CpG sites using
Illumina HumanMethylation450 BeadChip arrays, with hybridization and processing performed according to
the instructions of the manufacturer. For each CpG site and individual, we collected two data points: M (the
total methylated signal), and U (the total unmethylated signal). We set to missing data points with 1) a
detection p-value greater than 0.001 or 2) a combined signal less than 25% of the total median signal and less
than both the median unmethylated and median methylated signal. We removed individual samples from
analysis if they were outliers in a hierarchical clustering analysis or had 1) a mean total signal less than half of
the median of the overall mean signal or 2000 arbitrary units, or 2) a missingness rate above 5%. Similarly,
we removed from analysis CpG sites with a missingness rate above 10%. We then computed β-values for each
individual at each CpG site as the total methylated signal divided by the total signal.
Heart and Vascular Health Study (HVH)
The Heart and Vascular Health (HVH) study17-19 constitutes a group of population based case
control studies of myocardial infarction (MI), stroke, venous thromboembolism (VTE), and atrial fibrillation7.
Study participants were 30-79 year old members of Group Health, a large integrated health care organization
in Washington State. Cases were identified from hospital discharge diagnosis codes and subsequently
validated by medical record review. Cases shared a common control group that was a random sample of
Group Health members, frequency-matched to MI cases on age (within decade), sex, treated hypertension, and
calendar year of identification. The HVH study started in 1987 and blood specimen has been collected since
1995. Study eligibility, participant characteristics, and risk factor information were collected by medical
record review and telephone interview. In addition, surviving cases and controls who agreed to participate had
a blood draw.
Since 2003, whole blood has been collected in PAXGene tubes for mRNA expression studies.
Participants of the current study (N=348) are those for whom expression profiling was done as part of several
gene expression pilot studies conducted among HVH controls to investigate incident cardiovascular disease,
hormone therapy, medications, diabetes, and atrial fibrillation. The Group Health human subjects review
committee approved the study and all participants provided written informed consent.
Total RNA was extracted using PAXGene Blood RNA Kit and RNase-Free DNase Set (QIAGEN
Inc., Valencia, CA) at the Fred Hutchinson Cancer Research Center, Seattle, WA. RNA integrity and quality
was assessed using Agilent 2100 Bioanalyzer (Agilent Technologies Inc., Santa Clara, CA). Illumina®
TotalPrep™-96 RNA Amplification Kit (Life Technologies Corp., Carlsbad, CA) was used for RNA
amplification and labeling using manufacturer’s instructions. Labeled cRNAs were hybridized onto Illumina
HumanHT-12v3 and Illumina HumanHT-12v4 Expression Beadchip (Illumina, San Diego, CA) arrays,
according to manufacturer’s protocols. The images of the array chips were captured using an Illumina
Beadarray scanner and scanned array images were imported into Illumina’s GenomeStudio Gene Expression
40
Module. RNA quality control and microarray expression profiling experiments were conducted at the
laboratory of Dr. Jerome Rotter at the Medical Genetics Institute at Cedars-Sinai Medical Center, Los
Angeles, CA. The expression data is available at GEO (Gene Expression Omnibus) public repository under
the accession GSE47729.
Boston Cohort (CD4+ T cells and CD14+ monocytes)
Healthy European-American individuals were sampled from the population of Boston,
Massachusetts (n=211). Blood samples from each individual underwent flow cytometric purification to
independently isolate CD4+CD8-CD3+ T cells and CD14+CD16- monocytes. Resulting cDNA was profiled
using Affymetrix ST1.0 HuGene arrays. The sampled individuals ranged in age from 18 to 54 years of age.
The expression data is available at GEO (Gene Expression Omnibus) public repository under the accession
GSE56035.
Invecchiare in Chianti, ageing in the Chianti area (InCHIANTI)
The InCHIANTI study (http://www.inchiantistudy.net)20 is a population-based, prospective study of
human ageing in the Tuscany area of Italy. 1,455 participants were enrolled at baseline (1998-2000), with
follow-up waves every 3 years. Extensive interviews, questionnaires, medical examinations, physical tests and
blood samples were taken at every wave. Ethical approval was granted by the Instituto Nazionale Riposo e
Cura Anziani institutional review board in Italy, and participants gave informed consent to participate.
Peripheral blood specimens were collected at wave 4 (year 9, 2008⁄9) from 712 individuals, using
the PAXGene technology to preserve levels of mRNA transcripts as they were at the point of collection 21.
RNA was extracted from peripheral blood samples using the PAXGene Blood mRNA kit (Qiagen, Crawley,
UK) according to the manufacturer’s instructions. RNA was biotinylated and amplified using the Illumina®
TotalPrep22 -96 RNA Amplification Kit and directly hybridized with HumanHT-12_v3 Expression BeadChips
that include 48,803 probes. Image data was collected on an Illumina iScan and analyzed using the Illumina
and Beadstudio software (Illumina, San Diego, California, USA) as previously described23. All microarray
experiments and analyses complied with MIAME guidelines. The total number of InCHIANTI samples with
good quality whole-genome expression data equals 698, 695 of which also have cell-count data.
CpG methylation data was generated for a subset of the samples seen during follow-up wave 3 (the
‘gene expression’ wave) using the Illumina Infinium HumanMethylation450 BeadChip. Briefly, genomic
DNA was bisulfite converted using Zymo EZ-96 DNA Methylation Kit, followed by CpG analysis using the
aforementioned Illumina 450k array. Quality control of the samples included exclusion based on sexdiscrepancy and call-rate thresholds. Normalization of the arrays was performed using the ‘wateRmelon’ 24 R
package (specifically the DASEN method), which includes quantile normalization between probe-types and
arrays. Samples having 5% of sites with a detection P-value>0.01 were removed. After exclusions, 506
samples had robust data available for analysis 25. The expression data is available at GEO (Gene Expression
KOoperative gesundheitsforschung in der Region Augsburg (KORA)
KORA F4 (Cooperative Heath Research in the Region of Augsburg) is a population-based survey in
the region of Augsburg in Southern Germany. KORA exists since 1996 in the region of Augsburg in the
southwest of Germany, and it is a regional research platform for population-based surveys and follow-up
studies. Four cross-sectional health surveys have been performed in five-year intervals, each containing
independent random samples of individuals with German nationality resident in Augsburg city or one of
sixteen communities from the adjacent counties. 3,080 samples were collected for KORA F4 between 2006
and 200826. The study followed the recommendations of the Declaration of Helsinki and was approved by the
local ethical committees.
For the expression analysis, the subset from the survey F4 (2004-2006) of 1002 elderly individuals
aged 61 to 82 years was used27. Gene expression profiling was performed using the Illumina HumanHT12v3
BeadChip as described elsewhere28. RNA was isolated from whole blood under fasting conditions using
PAXGene Blood miRNA Kit (Qiagen, Hilden, Germany). Purity and integrity of the RNA was analysed using
the Agilent Bioanalyzer with the 6000 Nano LabChip reagent set (Agilent Technologies, Germany). Samples
with low quality were excluded after manually inspection. Using the Illumina TotalPrep-96 RNA Amp Kit
41
(Ambion), 500ng of RNA was reverse transcribed into cRNA, and biotin-UTP-labelled. 3000ng of cRNA was
hybridized to the Illumina HumanHT12v3 Expression BeadChips, followed by washing steps as described in
the Illumina protocol. After quality control, 993 samples were available for analysis. The expression data is
available at ArrayExpress public repository under the accession E-MTAB-1708.
Genome-wide DNA methylation patterns were analyzed using the Infinium HumanMethylation450
BeadChip array (Illumina) as described elsewhere29. The percentage of methylation at a given cytosine is
reported as a β-value, which is a continuous variable between 0 and 1, corresponding to the ratio of the
methylated signal over the sum of the methylated and unmethylated signals. The M-value is calculated as the
log2 ratio of the intensities of methylated probe vs. unmethylated probe30.
Raw methylation data were extracted with Illumina Genome Studio (version 2010.3) with
methylation module (version 1.8.5) and preprocessed using R (version 3.0.1). For data pre-processing of the
Infinium Human Methylation 450K BeadChip we used the pipeline described earlier with default parameter
settings to avoid bias in the analysis since the assay combines two different chemistries 31. In brief, CpG sites
in close proximity (50bp) to common SNPs and on allosomal positions were removed and color bias
adjustment based on a smooth quantile normalization method as well as background level correction based on
negative-control probes was performed for each chip using the R lumi package32. Finally, the pipeline
performs subset quantile normalization, including only probes with detection p-values < 0.01, in order to
correct for the InfI/InfII shift and normalize between samples. Therefore, the target CpGs were separated into
different categories using CpG island annotation. For analysis we considered only beta-values associated with
detection p-value < 0.01. Three samples were excluded due to chip wise detection rate < 80%.
Multi-Ethnic Study of Atherosclerosis (MESA)
The MESA study was designed to investigate the prevalence, correlates, and progression of
subclinical cardiovascular disease in a population cohort of 6,814 participants. Since its inception in 2000
there have been five clinic visits during which extensive clinical, socio-demographic, lifestyle and behavior,
laboratory, nutrition, and medication data were collected33. The present analysis is primarily based on analyses
of purified monocyte samples from the most recent examination (April 2010-February 2012) from 734
randomly selected MESA participants, 55-94 years old, from four MESA field centers (Baltimore, MD;
Forsyth County, NC; New York, NY; and St. Paul, MN).
Centralized training of technicians, standardized protocols, and numerous quality control (QC)
measures were implemented for collection, on-site processing, and shipment of MESA specimens and routine
calibration of equipment. Blood was initially collected in sodium heparin-containing Vacutainer CPTTM cell
separation tubes (Becton Dickinson, Rutherford, NJ) to separate peripheral blood mononuclear cells from
other elements within 2 hours from blood draw. Subsequently, monocytes were isolated with the anti-CD14
coated magnetic beads, respectively, using AutoMACs automated magnetic separation unit (Miltenyi Biotec,
Bergisch Gladbach, Germany). Based on flow cytometry analysis of 18 specimens, monocyte samples were
consistently greater than 90% pure.
DNA and RNA were isolated from samples simultaneously using the AllPrep DNA/RNA Mini Kit
(Qiagen, Inc., Hilden, Germany). QC metrics were examined on the DNA and RNA samples, including
optical density22 measurements, using a NanoDrop spectrophotometer and evaluation of the integrity of the
18s and 28s ribosomal RNA. RNA QC testing was performed using the Agilent 2100 Bioanalyzer with RNA
6000 Nano chips (Agilent Techonology, Inc., Santa Clara, CA) according to the manufacturer’s instructions.
RNA with RIN (RNA Integrity) scores > 9.0 was used for global gene expression microarrays.
The Illumina HumanHT-12 v4 Expression BeadChip and the Illumina Bead Array Reader were
used to perform the genome-wide expression analysis, following the Illumina expression protocol. The
Illumina TotalPrep-96 RNA Amplification Kit (Ambion/Applied Biosystems, Darmstadt, Germany) was used
for reverse transcription, and amplification with 500 ng of input total RNA (at 11ul). 700 ng of biotinylated
cRNA was hybridized to a BeadChip at 58°C for 16–17 hours. The expression data is available at GEO (Gene
Expression Omnibus) public repository under the accession GSE56045.
North American Brain Expression Consortium (NABEC) and United Kingdom Brain Expression Consortium
(UKBEC)
42
Frozen frontal cortex (FCTX) and cerebellum (CRBL) samples were obtained from > 399 selfreported European ancestry samples without determinable neuropathological evidence of disease 23,34-36.
mRNA expression levels were assayed using Illumina HumanHT-12 v3 Expression Beadchips. In brief,
individual probes were excluded from analyses if the p-value for detection was > 0.01 or there was less than
95% completeness of data per probe, and samples were excluded if <95% of probes were detected. Probes
were also removed if an analyzed SNP was within the probe or the probe mapped ambiguously to multiple
locations in the genome.
Expression data was quantile normalized and log2-transformed prior to analyses. Analyses were
carried out separately for each brain region. The total number of NABEC and UKBEC samples with good
quality whole-genome expression data was 394. The expression data is available at GEO (Gene Expression
For the methylation analysis, genomic DNA was extracted with phenol-chloroform. Bisulfite
converted DNA and assayed at > 27,000 sites on the Illumina Infinium HumanMethylation 27K BeadChips.
NIDDK-Phoenix Study (NIDDK/PHOENIX)
Subjects for the NIDDK-Phoenix study were selected from among participants in the Phoenix
extension of the Family Investigation of Nephropathy and Diabetes37. In this study, American Indians from
urban Phoenix, Arizona, are invited to have a screening examination for diabetes and nephropathy; beginning
in 2008 a PAXGene RNA tube (BD) was collected at each examination. Individuals for the present study were
selected among 1961 participants who had been fasting for ≥8 hours, who had been examined between 06:30
and 12:30 hours, and who did not have end-stage renal disease. The self-reported heritage of each individual
was ≥½ American Indian, and all participants were ≥ 18 years old. Information on family membership was
collected, and participants with diabetes or kidney disease were encouraged to refer family members. A total
of 1461 individuals were selected for expression studies: 768 from pedigrees with ≥2 individuals available,
and an additional 693, selected at random from the remaining potentially eligible individuals. Informed
consent was obtained from each participant, and the Institutional Review Board of the NIDDK approved the
study.
Total RNA was isolated using PAXGene Blood miRNA kits (Qiagen) according to the
manufacturer’s instructions. Samples were amplified and labelled (Ambion Message Ii Biotin-Enhanced
aRNA amplification kit), and hybridized to the Illumina HumanHT-12 v4 Expression Beadchips as described
by the manufacturer’s protocol. Samples were scanned on the Illumina BeadArray 500GX Reader and the
Illumina GenomeStudio software was used to perform a standard background normalization prior to exporting
the data for statistical analysis. Four samples (2 from the family sample and 2 from the random sample)
showed little evidence of overall expression above background levels and were excluded from analyses.
Expression studies for the NIDDK-Phoenix samples were performed at the Department of Genetics
Laboratories at Texas Biomedical Research Institute (San Antonio, Texas). The total number of NIDDKPhoenix samples with good quality whole-genome expression data was 1457. Data are not deposited in public
databases, but may be made available to potential collaborators, subject to IRB approval.
PBMC-MS
The PBMC-MS subjects were selected from the Comprehensive Longitudinal Investigation of
Multiple Sclerosis at the Brigham and Women's Hospital (CLMB), which has been described earlier 38.
PBMCs were collected between 2002 and 2007, and they were frozen and stored in liquid nitrogen. Total
RNA was isolated from RLT lysate using the RNeasy Mini kit (Qiagen) according to the manufacturer’s
instructions. After quality control (RIN >7), total RNA was amplified and labelled using the IVT RNA
Amplification and Labeling system (Affymetrix, Santa Clara, CA). The dataset was preprocessed with
SimpleAffy and quantile normalized following the GeneChip robust multiarray average (GCRMA) procedure
in Bioconductor 2.8 (www.bioconductor.org). The limma R package was used for differential expression
analysis39. Normalized data files and the .gct gene pattern compatible files were used in subsequent analyses.
The expression data is available at GEO (Gene Expression Omnibus) public repository under the accession
GSE16214.
Rotterdam Study (RS)
43
The Rotterdam Study (RS) (www.epib.nl/rotterdamstudy) is a prospective, population-based cohort
study in the district of Rotterdam, the Netherlands, and has been described in detail40. The initial design of the
study is straight-forward: a prospective cohort study among 7,983 persons living in the well-defined
Ommoord district in the city of Rotterdam (78% of 10,215 invitees), called Rotterdam Study I (or RS-I). They
were all 55 years of age or older and the oldest participant at the start was 106 years. The study started in the
second half of 1989. In 1999, 3,011 participants (out of 4,472 invitees) who had become 55 years of age or
moved into the study district since the start of the study were added to the cohort, called Rotterdam Study II
(or RS-II). In 2006, a further extension of the cohort was initiated in which 3,932 subjects were included, aged
45 years and older (out of 6,057 invited), called Rotterdam Study III (RS-III).
The participants were all examined in some detail at baseline. They were interviewed at home and
then had an extensive set of examinations in a specially built research facility in the centre of their district.
These examinations were repeated every 3–4 years in characteristics that could change over time. The
participants in the Rotterdam Study are followed for a variety of diseases that are frequent in the elderly.
Informed consent was obtained from each participant, and the medical ethics committee of the Erasmus
Medical Center Rotterdam approved the study.
For the expression analyses, the RS-III cohort was used: whole-blood was collected (PAXGene
Tubes – Becton Dickinson) and total RNA was isolated (PAXGene Blood RNA kits - Qiagen). To ensure a
constant high quality of the RNA preparations, all RNA samples were analysed using the Labchip GX
(Calliper) according to the manufacturer’s instructions. Samples with an RNA Quality Score > 7 were
amplified and labelled (Ambion TotalPrep RNA), and hybridized to the Illumina HumanHT12v4 Expression
Beadchips as described by the manufacturer’s protocol. Processing of the Rotterdam Study RNA samples was
performed at the Genetic Laboratory of Internal Medicine, Erasmus University Medical Center Rotterdam.
The RS-III expression dataset is available at GEO (Gene Expression Omnibus) public repository under the
accession GSE33828: 881 samples are available for analysis.
For the methylation analysis, genomic DNA was extracted from peripheral venous blood using the
salting-out method41. DNA methylation was assayed at over 450,000 sites on the Illumina Infinium
HumanMethylation 450K BeadChips. Quality control was performed in the R statistical programming
language using the minfi- and methylumi-package7,42. Total number of samples having both gene expression
and methylation data is 726.
San Antonio Family Heart Study (SAFHS)
The longitudinal San Antonio Family Heart Study (SAFHS, funded by the long-running NHLBI
program project 5P01HL04552, PI Blangero) started in 1991 and was designed to primarily investigate the
genetics of cardiovascular disease and its risk factors in Mexican Americans. The SAFHS included 1,431
individuals in 42 extended families at baseline. Ascertainment occurred by way of random selection of an
adult Mexican American proband, without regard to presence or absence of disease and almost exclusively
from Mexican American census tracts in San Antonio. These individuals have been followed in a mixed
longitudinal fashion, with the average participant having been seen ~2.5 times (ranging from 1 to 4 times). A
wide range of phenotypic information is available. Blood samples were obtained in the morning after an
overnight fast, and mRNA was isolated in lymphocytes only.
Expression profiles were generated for 1,371 lymphocyte samples (from the first clinic visit of
study participants, and subsequently stored at -80C w/o interruption before processing) in total, including
various controls and duplicates, using Illumina's WG6v1 microarrays (47,293 probes in total). This is an early
generation Illumina platform, which did not include all 2,238 age-associated genes for replication. We
identified "good" expression data samples based on the number of detected probes (at detection p-values <=
0.05), mean average raw signal across all transcripts, and mean correlation against all other samples across all
probes. Samples falling within the bottom 5% in each of these 3 quality measures were deleted, as were
controls. Among duplicate samples, we kept the one giving the "best" quality results based on these measures.
At the end of the day, this resulted in 1,244 samples with high quality expression data43. The gene expression
data was then processed by background noise subtraction, log2 transformation, and quantile normalization.
We used SOLAR44 to analyze what transcripts were associated with age. A random effects
"polygenic" model, based on the kinship matrix of study participants, was used to model the genetic nonindependence of family members based on their expected average autosomal sharing based on stated (and also
44
statistically verified) pedigree relationships, and age (at time of blood draw) was included as an additional
covariate in the analysis. The expression data is available at the ArrayExpress public repository under the
accession E-TABM-305.
Study of Health In Pomerania (SHIP-TREND)
SHIP (Study of Health in Pomerania) is a longitudinal population-based project consisting of two
independent cohorts, SHIP and SHIP-TREND, assessing the prevalence and incidence of common, population
relevant diseases and their risk factors. Baseline examinations for SHIP-TREND were conducted between
2008 and 2012. The study region of SHIP is West Pomerania, a region in the north-east of Germany.
Stratification variables for sampling from population registries were age and sex. Study design and sampling
methods were previously described45,46. A total number of 4420 Caucasian adults aged 20 to 79 years
(response 50.1%) participated in the baseline SHIP-TREND. The medical ethics committee of the University
of Greifswald approved the study protocol, and oral and written informed consents were obtained from all
study participants.
For this analysis, a subset of the SHIP-TREND cohort with available phenotype and gene
expression data (n=991) was used: RNA was prepared from whole blood under fasting conditions in
PAXGene tubes (BD) using the PAXGene Blood miRNA Kit (Qiagen, Hilden, Germany): this was done on a
QIAcube according to protocols provided by the manufacturer (Qiagen). To ensure a constant high quality of
the RNA preparations, all RNA samples were analysed using RNA 6000 Nano LabChips (Agilent
Technologies) on a 2100 Bioanalyzer (Agilent Technologies) according to the manufacturer’s instructions.
Using the Illumina TotalPrep-96 RNA Amp Kit (Ambion), 500ng of RNA was reverse transcribed into cRNA,
and biotin-UTP-labelled. 3000ng of cRNA were hybridized to the Illumina Whole-Genome Human HT12v3
Expression BeadChips, followed by washing steps as described in the Illumina protocol. Processing of the
SHIP-TREND RNA samples was performed at the Helmholtz Zentrum München. The expression data is
available at GEO (Gene Expression Omnibus) public repository under the accession GSE36382.
45
SUPPLEMENTARY NOTE 2
Additional acknowledgements
The infrastructure for the CHARGE Consortium is supported in part by the National Heart, Lung, and Blood
Institute grant R01HL105756. This study was funded by the European Commission (HEALTH-F2-2008201865, GEFOS; HEALTH-F2-2008 35627, TREAT-OA), the Netherlands Organization for Scientific
Research (NWO) Investments (nr. 175.010.2005.011, 911-03-012), the Netherlands Consortium for Healthy
Ageing9, the Netherlands Genomics Initiative (NGI) / Netherlands Organization for Scientific Research
(NWO) project nr. 050-060-810 and VIDI grant 917103521. Additionally, this work was supported by the
German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research
and funding concept (grant 01ZX1313A-2014).
BSGS
The Brisbane Systems Genetics Study (BSGS) is supported by the Australian National Health and
Medical Research Council (NHMRC) grants 389892, 496667, 613601, 1010374 and 1046880, the Australian
Research Council (ARC) grant (DE130100691), and by National Institutes of Health (NIH) grants GM057091
and GM099568. We also acknowledge Anthony Caracella and Lisa Bowdler for sample collection and
processing.
DILGOM
Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome study (DILGOM).
We thank the participants of the DILGOM study. Study was supported by Academy of Finland (DILGOM
grant # 118065, 140747 to I.H. 251217 to S.R., 139635 to V.S. and 283045, 266199 to J.K.), the
Finnish foundation for Cardiovascular Research to S.R., V.S. and M.P., the Sigrid Juselius Foundation to S.R.
and I.H. and Biocentrum Helsinki to S.R.
EGCUT
EGCUT received financing from FP7 programs (ENGAGE, OPENGENE), targeted financing from
Estonian Government SF0180142s08, Estonian Research Roadmap through Estonian Ministry of Education
and Research, Center of Excellence in Genomics (EXCEGEN) and University of Tartu (SP1GVARENG), and
from Estonian Research Council IUT2-2 grant and European Regional Development Fund. Also we
acknowledge EGCUT technical personnel, especially Mr V. Soo and S. Smit. Data analyses were carried out
in part in the High Performance Computing Center of University of Tartu.
FEHRMANN
This work is supported by the Netherlands Organization for Scientific Research [NWO-VENI grant
916.10.135 to LF], and a Horizon Breakthrough grant from the Netherlands Genomics Initiative [grant
92519031 to LF]. The research leading to these results has received funding from the European Community's
Health Seventh Framework Programme (FP7/2007–2013) under grant agreement n° 259867. This study was
financed in part by the SIA-raakPRO subsidy for project BioCOMP.
FHS
The National Heart, Lung, and Blood Institute's Framingham Heart Study is supported by NIH
grant NO1-HC-25195. The Systems Approach to Biomarker Research in Cardiovascular Disease (SABRe
CVD) Initiative is funded by the Division of Intramural Research, National Heart, Lung, and Blood Institute,
Bethesda, MD. Dr. J. M. Murabito is supported by R01 AG29451. Dr. R. Joehanes, D. Levy, P. Munson and
A.D. Johnson were supported by NHLBI Intramural Funds.
GARP
This study was supported by the Leiden University Medical Centre and the Dutch Arthritis
Association. Pfizer Inc., Groton, CT, USA supported the inclusion of the GARP study. The research leading
to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-
46
2011) under grant agreement n° 259679 and from BBMRI-NL, a research infrastructure financed by the Dutch
government: NWO 184.021.007.
GENOA
Support for the Genetic Epidemiology Network of Arteriopathy (GENOA) was provided by the
National Heart, Lung and Blood Institute of the National Institutes of Health (HL054464, HL054457,
HL054481, HL087660, and NS041558). We would also like to thank the families that participated in the
GENOA study.
GTP
This work was primarily supported by the National Institute of Mental Health (MH096764 and
MH071537 to K.J.R.). Support was also received from Emory and Grady Memorial Hospital General Clinical
Research Center, the Max Planck Society, the Behrens-Weise Foundation, NIH National Centers for Research
Resources (M01RR00039), and the National Center for Advancing Translational Sciences of the NIH
(UL1TR000454).
HVH
HVH was supported in part by grants R01 HL085251 and R01 HL073410 from the National Heart,
Lung, and Blood Institute (NHLBI). The provision of genomic data was supported in part by the National
Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and National Institute of Diabetes
and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern
California Diabetes Research Center. The content is solely the responsibility of the authors and does not
necessarily represent the official views of the NHLBI or the National Institutes of Health, USA. Dr. Psaty
serves on a DSMB for a clinical trial of a device funded by Zoll LifeCor and on the Steering Committee for
the Yale Open Data Access Project funded by Johnson & Johnson. Both activities are unrelated to this work.
InCHIANTI
This study was supported in part by the Intramural Research Program, National Institute on Ageing.
UK based work was generously supported by a Wellcome Trust Institutional Strategic Support Award
(WT097835MF), plus internal University of Exeter Medical School funding. This work has made use of the
resources provided by the University of Exeter Science Strategy and resulting Systems Biology initiative.
The Jackson Laboratory
This work was supported by a Nathan Shock Center grant AG 25707 from the National Institute of
Ageing, NIH, USA and by an Ellison Medical Foundation Senior Investigator Award to Beverly Paigen. We
thank Scott Leiser and Matt Kaeberlein (University of Washington, Seattle, WA, USA) as well as Jarod
Rollins, Aric Rogers, and Dustin Updike (Mount Desert Island Biological Laboratory, Bar Harbor, ME, USA)
for useful discussion in resolving technical problems. C. elegans reagents and experiments were also
supported by NHLBI intramural funds from A.D.J.
KORA
The KORA research platform and the KORA Augsburg studies are financed by the Helmholtz
Zentrum München, German Research Center for Environmental Health, which is funded by the BMBF and by
the State of Bavaria. Furthermore, KORA research was supported within the Munich Center of Health
Sciences (MC Health), Ludwig Maximilians-Universität, as part of the LMUinnovative and by a grant from
the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research
(DZD e. V.).This work was supported by the Ministry of Science and Research of the State of North RhineWestphalia (MIWF NRW) and the German Federal Ministry of Health (BMG).. Additional support was
obtained from the BMBF (National Genome Research Network NGFNplus Atherogenomics, 01GS0834), by
the DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung – German Centre for Cardiovascular Research)
and from the European Commission’s Seventh Framework Programme (FP7/2007-2013, HEALTH-F2-2011,
grant agreement No. 277984, TIRCON and HEALTH-F2-2013, grant agreement No. 603288, SysVasc). We
47
thank the field staff in Augsburg who was involved in the conduct of the studies. We thank Katja Junghans
and Anne Löschner (Helmholtz Zentrum München) for excellent technical assistance.
MESA
This research was supported by contracts N01-HC-from the National Heart, Lung and Blood
Institute and by grants UL1-RR-024156 and UL1-RR-025005 from the National Center for Research
Resources. The MESA Epigenomics & Transcriptomics Study was funded by NHLBI grant R01HL101250 to
Wake Forest University Health Sciences. The authors thank the other investigators, the staff, and the
participants of the MESA study for their valuable contributions. A full list of participating MESA
investigators and institutions can be found at http://www.mesa-nhlbi.org.
NABEC and UKBEC
The work performed by the North American Brain Expression Consortium (NABEC) was
supported in part by the Intramural Research Program of the National Institute on Ageing, National Institutes
of Health, part of the US Department of Health and Human Services; project number ZIA AG000932-04. In
addition this work was supported by a Research Grant from the Department of Defense, W81XWH-09-20128. This study utilized the high-performance computational capabilities of the Biowulf Linux cluster at the
National Institutes of Health, Bethesda, Md. (http://biowulf.nih.gov).
The work performed by the UK Brain Expression Consortium (UKBEC) was supported by the
MRC through the MRC Sudden Death Brain Bank (C.S.), by a Project Grant (G0901254 to J.H. and M.W.)
and by a Fellowship award (G0802462 to M.R.). D.T. was supported by the King Faisal Specialist Hospital
and Research Centre, Saudi Arabia. Computing facilities used at King's College London were supported by
the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas'
NHS Foundation Trust and King's College London. We would like to thank AROS Applied Biotechnology
AS company laboratories and Affymetrix for their valuable input.
NIDDK/PHOENIX
This work was supported by the intramural research program of the National Institute of Diabetes
and Digestive and Kidney Diseases, Bethesda, MD.
PBMC-MC and the Boston Cohort (CD4+ and CD14+ cells)
T.R. is supported by the NIH F32 Fellowship (F32 AG043267). We thank all study participants in the
Phenogenetic project for their contributions.
RS
The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam,
Netherlands Organization for the Health Research and Development (ZonMw), the Netherlands Organisation
of Scientific Research NWO Investments (nr. 175.010.2005.011, 911-03-012), the Research Institute for
Diseases in the Elderly (014-93-015; RIDE2), the Ministry of Education, Culture and Science, the Ministry
for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. The
authors are grateful to the study participants, the staff from the Rotterdam Study and the participating general
practitioners and pharmacists.
The generation and management of RNA-expression array data for the Rotterdam Study was
executed and funded by the Human Genotyping Facility of the Genetic Laboratory of the Department of
Internal Medicine, Erasmus MC, the Netherlands. We thank Ms. Mila Jhamai, Ms. Jeannette M. VergeerDrop, Ms. Bernadette van Ast-Copier, and Mr. Marijn Verkerk for their help in creating the RNA array
expression database.
SAFHS
SAFHS was supported in this effort by funding from R01AG031277 (SWB), P01HL045522 (JB),
R37MH059490 (JB) and the Azar Foundation (JB).
SHIP-TREND
48
SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany,
which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and
01ZZ0403), the Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of
Mecklenburg-West Pomerania, and the network ‘Greifswald Approach to Individualized Medicine
(GANI_MED)’ funded by the Federal Ministry of Education and Research (grant 03IS2061A). Genome-wide
data have been supported by the Federal Ministry of Education and Research (grant no. 03ZIK012) and a joint
grant from Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg, West Pomerania.
The University of Greifswald is a member of the 'Center of Knowledge Interchange' program of the Siemens
AG and the Caché Campus program of the InterSystems GmbH.
Individuals not attached to cohorts
AZ is supported by “IN-CONTROL” grant by Cardiovascular Research Netherlands (CVON), and
from Rosalind Franklin Fellowship, University of Groningen, the Netherlands.
The authors are very grateful to the participants, the staff, the general practitioners, and the pharmacist from
all participating studies.
49
SUPPLEMENTARY REFERENCES
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
Falchi, M. et al. Genome-wide association study identifies variants at 9p21 and 22q13 associated with
development of cutaneous nevi. Nature Genetics 41, 915-919 (2009).
Perola, M. et al. Combined genome scans for body stature in 6,602 European twins: evidence for
common Caucasian loci. PLoS Genet 3, e97 (2007).
Powell, J. E. et al. The Brisbane Systems Genetics Study: genetical genomics meets complex trait
genetics. PLoS One 7, e35430 (2012).
Powell, J. E. et al. Congruence of additive and non-additive effects on gene expression estimated from
pedigree and SNP data. PLoS Genet 9, e1003502 (2013).
McRae, A. F. et al. Contribution of genetic variation to transgenerational inheritance of DNA
methylation. Genome Biol 15, R73 (2014).
Inouye, M. et al. An immune response network associated with blood lipid levels. PLoS Genet 6,
e1001113 (2010).
Aryee, M. J. et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of
Infinium DNA methylation microarrays. Bioinformatics 30, 1363-1369 (2014).
Maksimovic, J., Gordon, L. & Oshlack, A. SWAN: Subset-quantile within array normalization for
illumina infinium HumanMethylation450 BeadChips. Genome Biol 13, R44 (2012).
Dubois, P. C. et al. Multiple common variants for celiac disease influencing immune gene expression.
Nature Genetics 42, 295-302 (2010).
Fehrmann, R. S. et al. Trans-eQTLs reveal that independent genetic variants associated with a
complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet 7,
e1002197 (2011).
Feinleib, M., Kannel, W. B., Garrison, R. J., McNamara, P. M. & Castelli, W. P. The Framingham
Offspring Study. Design and preliminary data. Prev Med 4, 518-525 (1975).
Riyazi, N. et al. Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis
in siblings with multiple joint involvement: the GARP study. Annals of the rheumatic diseases 64,
438-443 (2005).
Ramos, Y. F. et al. Genes expressed in blood link osteoarthritis with apoptotic pathways. Annals of
the rheumatic diseases 73, 1844-1853 (2014).
Daniels, P. R. et al. Familial aggregation of hypertension treatment and control in the Genetic
Epidemiology Network of Arteriopathy (GENOA) study. Am J Med 116, 676-681 (2004).
Turner, S. T. et al. Genomic susceptibility Loci for brain atrophy, ventricular volume, and
leukoaraiosis in hypertensive sibships. Arch Neurol 66, 847-857 (2009).
Gillespie, C. F. et al. Trauma exposure and stress-related disorders in inner city primary care patients.
Gen Hosp Psychiatry 31, 505-514 (2009).
Heckbert, S. R. et al. Antihypertensive treatment with ACE inhibitors or beta-blockers and risk of
incident atrial fibrillation in a general hypertensive population. Am J Hypertens 22, 538-544 (2009).
Psaty, B. M. et al. The risk of myocardial infarction associated with antihypertensive drug therapies.
JAMA 274, 620-625 (1995).
Smith, N. L. et al. Esterified estrogens and conjugated equine estrogens and the risk of venous
thrombosis. JAMA 292, 1581-1587 (2004).
Ferrucci, L. et al. Subsystems contributing to the decline in ability to walk: bridging the gap between
epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc 48, 1618-1625 (2000).
Debey-Pascher, S., Eggle, D. & Schultze, J. L. RNA stabilization of peripheral blood and profiling by
bead chip analysis. Methods Mol Biol 496, 175-210 (2009).
Broer, L. et al. GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3
Candidacy. J Gerontol A Biol Sci Med Sci (2014).
Gibbs, J. R. et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in
human brain. PLoS Genet 6, e1000952 (2010).
Pidsley, R. et al. A data-driven approach to preprocessing Illumina 450K methylation array data.
BMC Genomics 14, 293 (2013).
50
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
Holly, A. C. et al. Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript
expression in older humans. Mech Ageing Dev 135, 50-56 (2014).
Holle, R., Happich, M., Lowel, H. & Wichmann, H. E. KORA--a research platform for population
based health research. Gesundheitswesen 67 Suppl 1, S19-25 (2005).
Rathmann, W. et al. Incidence of Type 2 diabetes in the elderly German population and the effect of
clinical and lifestyle risk factors: KORA S4/F4 cohort study. Diabet Med 26, 1212-1219 (2009).
Mehta, D. et al. Impact of common regulatory single-nucleotide variants on gene expression profiles
in whole blood. Eur J Hum Genet 21, 48-54 (2013).
Zeilinger, S. et al. Tobacco smoking leads to extensive genome-wide changes in DNA methylation.
PLoS One 8, e63812 (2013).
Du, P. et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by
microarray analysis. BMC Bioinformatics 11, 587 (2010).
Touleimat, N. & Tost, J. Complete pipeline for Infinium((R)) Human Methylation 450K BeadChip
data processing using subset quantile normalization for accurate DNA methylation estimation.
Epigenomics 4, 325-341 (2012).
Du, P., Kibbe, W. A. & Lin, S. M. lumi: a pipeline for processing Illumina microarray. Bioinformatics
24, 1547-1548 (2008).
Bild, D. E. et al. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 156,
871-881 (2002).
Hernandez, D. G. et al. Integration of GWAS SNPs and tissue specific expression profiling reveal
discrete eQTLs for human traits in blood and brain. Neurobiol Dis 47, 20-28 (2012).
Trabzuni, D. et al. Quality control parameters on a large dataset of regionally dissected human control
brains for whole genome expression studies. J Neurochem 119, 275-282 (2011).
Trabzuni, D. et al. MAPT expression and splicing is differentially regulated by brain region: relation
to genotype and implication for tauopathies. Human molecular genetics 21, 4094-4103 (2012).
Knowler, W. C. et al. The Family Investigation of Nephropathy and Diabetes (FIND): design and
methods. J Diabetes Complications 19, 1-9 (2005).
Ottoboni, L. et al. An RNA profile identifies two subsets of multiple sclerosis patients differing in
disease activity. Sci Transl Med 4, 153ra131 (2012).
Smyth, G. K. Bioinformatics and Computational Biology Solutions Using R and Bioconductor.
Chapter 23: Limma. . (Springer New York, 2005).
Hofman, A. et al. The Rotterdam Study: 2014 objectives and design update. European journal of
epidemiology 28, 889-926 (2013).
Miller, S. A., Dykes, D. D. & Polesky, H. F. A simple salting out procedure for extracting DNA from
human nucleated cells. Nucleic Acids Res 16, 1215 (1988).
Davis S, D. P., Bilke S, Triche T, Jr. , Bootwalla M, Methylumi: Handle Illumina methylation data. ,
R package version 2.12.0. (2014).
Goring, H. H. et al. Discovery of expression QTLs using large-scale transcriptional profiling in
human lymphocytes. Nature Genetics 39, 1208-1216 (2007).
Almasy, L. & Blangero, J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J
Hum Genet 62, 1198-1211 (1998).
John, U. et al. Study of Health In Pomerania (SHIP): a health examination survey in an east German
region: objectives and design. Soz Praventivmed 46, 186-194 (2001).
Volzke, H. et al. Cohort profile: the study of health in Pomerania. Int J Epidemiol 40, 294-307 (2011).
51
Supplementary.Data.1.Peters
UniqueID
25716
53561
40285
25872
4817
46463
42813
26516
10875
53320
24556
19209
870
36165
19968
10095
17155
42901
42391
1683
63678
22336
66070
37087
34551
48770
45536
21050
60140
61240
62618
26051
7874
43329
53918
27356
31436
48072
6504
17478
17811
61667
38458
57114
39063
56533
9507
35729
26614
20610
46307
62221
32334
23999
29562
19751
61718
45713
68080
62353
30997
61231
44530
14179
27375
25961
19586
22579
25893
32844
13915
26501
61503
8657
25675
34119
21384
44129
39754
23293
26107
24813
48024
15878
18783
47389
66851
52164
33805
25301
19866
30850
48804
48422
45185
14527
22104
48606
53254
48520
21452
15322
23159
30329
29980
59712
56920
37995
28943
21923
32267
45653
27379
53443
36396
55098
10508
25946
7780
38647
32044
3532
60174
53948
59333
31280
32472
33350
56687
56289
30212
21419
59345
4068
39756
67665
23131
66899
28340
7980
65873
41280
34218
8935
62617
63521
38259
RANK
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
sign-DISC
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
sign-REPL
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
NEW-Entrez-ID
57124
54674
4753
51176
1236
3983
2999
4609
939
399665
5270
117247
8857
9289
60468
23208
5152
9241
2317
4907
83888
7049
81618
80063
1380
9214
26227
3945
55423
343413
5150
51070
10606
28969
92106
1524
6322
6146
26119
389
4050
54463
81606
11098
203328
113791
4240
79814
4818
5521
3002
9057
55020
3615
10750
4925
2091
79899
6304
3575
65982
154
3820
3326
29802
6932
114879
3512
81563
64919
9397
8718
5796
121551
10913
6785
3956
26249
926
26960
9891
220158
80310
301
164668
472
3399
91523
22837
51237
2841
95681
2113
150864
2053
814
255231
1235
7294
23484
8942
2149
5551
1736
9254
10252
493
2308
79148
5641
8832
79961
23059
132299
3001
973
5159
11123
27075
51361
57189
79896
471
79612
3486
64420
940
6097
25788
57134
55342
6894
55024
1316
3824
6955
348378
10360
9839
10791
7710
1606
2648
5450
2041
7169
708
NEW-Gene-ID
CD248
LRRN3
NELL2
LEF1
CCR7
ABLIM1
GZMH
MYC
CD27
FAM102A
SERPINE2
SLC16A10
FCGBP
GPR56
BACH2
SYT11
PDE9A
NOG
FLNB
NT5E
FGFBP2
TGFBR3
ITM2C
ATF7IP2
CR2
FAIM3
PHGDH
LDHB
SIRPG
FCRL6
PDE7A
NOSIP
PAICS
BZW2
OXNAD1
CX3CR1
SCML1
RPL22
LDLRAP1
RHOC
LTB
FAM134B
LBH
PRSS23
SUSD3
PIK3IP1
MFGE8
AGMAT
NKG7
PPP2R2B
GZMB
SLC7A6
TTC38
IMPDH2
GRAP
NUCB2
FBL
PRR5L
SATB1
IL7R
ZSCAN18
ADRB2
KLRB1
HSP90AB1
VPREB3
TCF7
OSBPL5
IGJ
C1orf21
BCL11B
NMT2
TNFRSF25
PTPRK
BTBD11
EDAR
ELOVL4
LGALS1
KLHL3
CD8B
NBEA
NUAK1
GTSCR1
PDGFD
ANXA1
APOBEC3H
ATM
ID3
PCED1B
COBLL1
MZB1
GPR18
CEP41
ETS1
FAM117B
EPHX2
CAMK4
MCOLN2
CCR6
TXK
LEPROTL1
KYNU
F2R
PRF1
DKC1
CACNA2D2
SPRY1
ATP2B4
FOXO1
MMP28
LGMN
CD84
DENND2D
CLUAP1
OCIAD2
GZMA
CD79A
PDGFRB
RCAN3
TSPAN13
HOOK1
KIAA1147
THNSL1
ATIC
NAA16
IGFBP3
SUSD1
CD28
RORC
RAD54B
MAN1C1
STRBP
TARBP1
BANK1
KLF6
KLRD1
TRA@
FAM159A
NPM3
ZEB2
VAMP5
ZNF154
DGKA
KAT2A
POU2AF1
EPHA1
TPM2
C1QBP
DISC: WB
------------------------------++-+++
------------------?-----------++-+++
-----++-+++
--------------------++++++
++++++
-----------------------------------++++++
-------------------------+++?++
---------------++++++
---------------++++++
---?----------------++-+++
++-+++
++++++
-----++++++
------------+-------++++++
---------------++++++
--------------------++++++
-----++++++
---?-------------------------------++++++
---------------++++++
++++++
++++++
++++++
++-+++
-----------------------?-------------------------------++-+++
---?-----------++++++
++++++
++-+++
-----++++++
-----++-+++
---------------++-+++
---------------++-+++
---?-++++++
--------------------------------+--++-+++
++++++
-----------------------------------++++++
++++++
---?-----------+
++++++
++++++
------------------------------------
Weight
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
Zscore
-32.476
-29.119
-23.650
-22.178
-21.138
-22.321
18.681
-18.964
-17.647
-19.464
-16.077
-20.385
-15.764
17.524
-17.824
17.225
-17.210
-17.006
-15.780
-17.453
17.449
14.997
-14.414
-15.515
-16.293
-17.917
-13.249
-15.633
-15.636
13.285
-15.584
-14.435
-16.001
-14.927
-15.586
14.094
-13.999
-14.906
-14.573
12.894
-14.895
-15.167
-14.176
14.071
-14.258
-14.933
-12.460
-13.765
14.434
13.489
14.190
-15.235
13.878
-14.089
-14.824
-12.039
-13.815
13.690
-13.046
-16.737
-13.576
13.205
-13.010
-14.161
-12.905
-13.330
13.939
-8.883
11.889
-13.517
-14.499
-13.869
-12.737
-12.171
-13.062
-14.909
13.568
-13.185
-11.084
-10.843
15.281
10.450
12.147
11.425
11.567
-13.685
-11.836
-13.304
-12.922
-9.708
-13.679
-13.480
-13.493
-12.098
-12.692
-14.466
10.173
-13.806
-11.805
-12.769
12.767
12.787
11.509
-13.417
11.259
-13.530
11.622
-12.571
-14.522
-11.544
10.260
-14.258
-13.254
-13.317
11.425
-10.010
13.868
-11.930
-12.035
-13.054
-14.162
-12.087
-11.665
-10.012
8.426
12.088
-14.157
-12.012
-10.353
-10.499
-11.768
-10.079
-12.184
10.661
12.142
-13.632
-12.508
-9.514
12.459
12.649
-12.344
-13.564
-9.395
-9.201
-12.169
-11.842
-11.398
Direction
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
P
2.32E-231
2.03E-186
1.18E-123
5.57E-109
3.59E-99
2.34E-110
7.03E-78
3.36E-80
1.07E-69
2.24E-84
3.71E-58
2.29E-92
5.50E-56
9.47E-69
4.64E-71
1.72E-66
2.22E-66
7.41E-65
4.26E-56
3.29E-68
3.51E-68
7.73E-51
4.24E-47
2.73E-54
1.10E-59
8.65E-72
4.56E-40
4.33E-55
4.16E-55
2.83E-40
9.40E-55
3.12E-47
1.26E-57
2.19E-50
9.09E-55
4.14E-45
1.58E-44
3.03E-50
4.19E-48
4.89E-38
3.55E-50
5.88E-52
1.29E-45
5.76E-45
4.01E-46
2.02E-50
1.23E-35
4.14E-43
3.17E-47
1.81E-41
1.06E-45
2.07E-52
8.64E-44
4.44E-45
1.02E-49
2.22E-33
2.07E-43
1.16E-42
6.66E-39
7.07E-63
5.56E-42
8.18E-40
1.08E-38
1.59E-45
4.22E-38
1.55E-40
3.69E-44
6.52E-19
1.35E-32
1.24E-41
1.24E-47
9.70E-44
3.69E-37
4.44E-34
5.44E-39
2.90E-50
6.17E-42
1.07E-39
1.50E-28
2.15E-27
1.02E-52
1.46E-25
5.99E-34
3.13E-30
6.04E-31
1.25E-42
2.55E-32
2.18E-40
3.40E-38
2.77E-22
1.35E-42
2.04E-41
1.73E-41
1.08E-33
6.52E-37
1.98E-47
2.63E-24
2.34E-43
3.67E-32
2.44E-37
2.50E-37
1.93E-37
1.19E-30
4.81E-41
2.08E-29
1.05E-41
3.19E-31
3.06E-36
8.79E-48
7.94E-31
1.06E-24
3.98E-46
4.27E-40
1.84E-40
3.14E-30
1.38E-23
9.90E-44
8.23E-33
2.32E-33
6.06E-39
1.58E-45
1.24E-33
1.92E-31
1.36E-23
3.58E-17
1.23E-33
1.69E-45
3.07E-33
4.04E-25
8.69E-26
5.70E-32
6.87E-24
3.78E-34
1.55E-26
6.33E-34
2.57E-42
6.71E-36
1.84E-21
1.25E-35
1.13E-36
5.26E-35
6.53E-42
5.70E-21
3.54E-20
4.54E-34
2.36E-32
4.30E-30
Correlation-with-DISCOVERY:
REPL: WB
Weight
-------8009
-------8009
-------8009
-------8009
-------8009
-------8009
+++-++++
8009
-------8009
-------8009
-------8009
-------8009
------?6552
-------8009
++++++++
8009
-------8009
++++++++
8009
-------8009
-------8009
-------8009
-----?-7782
+++-++++
8009
++++++++
8009
-------8009
-------8009
-------8009
-------8009
-------8009
-------8009
-------8009
+++-++++
8009
-------8009
-------8009
-------8009
-------8009
-------8009
++++++++
8009
-------8009
-------8009
-------8009
++++++++
8009
-------8009
-------8009
-------8009
+++-++++
8009
-------8009
-------8009
-------8009
-------8009
++++++++
8009
++++++++
8009
++++++++
8009
-------8009
+++-++++
8009
-------8009
-------8009
-------8009
-------8009
++++++++
8009
-------8009
-------8009
-------8009
++++++++
8009
-------8009
-------8009
---+---8009
-------8009
++++++++
8009
-------8009
++++++?+
6552
-------8009
-------8009
-------8009
-----??6325
-------8009
-------8009
-------8009
++++++++
8009
-------8009
----+--8009
+---???6204
++++++++
8009
++++++++
8009
8009
+++-++++
++++--++
8009
++++++++
8009
-------8009
-------8009
-------8009
-------8009
----+--8009
-------8009
-------8009
-------8009
-------8009
-----+-8009
+----+-8009
++++++++
8009
---+--+8009
-----+-8009
-------8009
++++++++
8009
++++++++
8009
++++++++
8009
-------8009
++++++++
8009
-------8009
++++++++
8009
-------8009
-----??6325
-------8009
++++++++
8009
-?-----7497
-------8009
-------8009
++++++++
8009
---+---8009
-+++++++
8009
-------8009
-------8009
-------8009
-------8009
-----+-8009
-------8009
----+--8009
++++--++
8009
++++++++
8009
-------8009
-------8009
-------8009
-------8009
---+---8009
-------8009
-------8009
++++++++
8009
+++-++++
8009
-------8009
-------8009
-------8009
++++--++
8009
++++++++
8009
-------8009
-------8009
-------8009
-------8009
-------8009
-------8009
-------8009
0.972
Zscore
-40.13
-33.55
-23.48
-22.46
-22.44
-20.73
20.97
-19.51
-20.68
-18.68
-20.95
-16.51
-20.83
19.02
-17.75
18.23
-18.20
-17.52
-18.61
-16.59
15.79
17.66
-17.73
-16.61
-15.85
-14.22
-18.30
-15.96
-15.45
17.65
-15.37
-16.19
-14.34
-15.18
-14.32
15.66
-15.69
-14.79
-14.82
15.93
-14.02
-13.43
-14.22
14.07
-13.91
-13.13
-15.34
-14.09
13.42
14.26
13.56
-12.50
13.62
-13.34
-12.56
-15.18
-13.15
13.13
-13.72
-10.17
-12.96
13.28
-13.46
-12.36
-13.55
-13.04
12.37
-17.12
14.24
-12.61
-11.59
-12.12
-13.18
-13.29
-12.40
-10.55
11.66
-12.02
-13.91
-14.22
9.75
14.31
12.66
13.33
13.13
-11.09
-12.74
-11.33
-11.67
-14.53
-10.82
-10.84
-10.74
-12.01
-11.44
-9.74
13.77
-10.45
-12.17
-11.22
11.19
11.17
12.37
-10.44
12.45
-10.26
11.92
-11.01
-8.80
-11.96
13.17
-9.21
-10.23
-10.15
11.90
-13.12
9.52
-11.24
-11.13
-10.15
-9.09
-11.03
-11.41
-12.93
14.43
10.93
-8.88
-10.83
-12.31
-12.14
-10.93
-12.53
-10.51
11.94
10.48
-9.17
-10.04
-12.89
10.03
9.82
-10.09
-8.92
-12.81
-12.98
-10.11
-10.38
-10.70
Direction
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
META
P
META: Weight
4.07e-352
15266
7.81E-247
15266
6.93E-122
15266
9.38E-112
15266
1.48E-111
15266
1.71E-95
15266
1.26E-97
15266
9.94E-85
15266
5.13E-95
15266
7.11E-78
15266
1.91E-97
14385
3.15E-61
13809
2.49E-96
15266
1.21E-80
15266
1.85E-70
15266
3.24E-74
15266
5.44E-74
15266
9.87E-69
15266
2.87E-77
15266
8.23E-62
15039
3.51E-56
15266
9.15E-70
15266
2.45E-70
15266
5.85E-62
15266
1.51E-56
15266
7.40E-46
15266
8.10E-75
15266
2.42E-57
15266
7.71E-54
15266
9.90E-70
15266
2.68E-53
15266
5.74E-59
15266
1.29E-46
15266
4.55E-52
15266
1.71E-46
15266
3.04E-55
14385
1.92E-55
15266
1.79E-49
15266
1.15E-49
15266
3.71E-57
15266
1.11E-44
15266
3.96E-41
15266
7.04E-46
15266
6.25E-45
15266
5.30E-44
14385
2.16E-39
15266
4.09E-53
15266
4.34E-45
15266
4.53E-41
15266
4.19E-46
15266
6.69E-42
15266
7.42E-36
15266
3.21E-42
15266
1.34E-40
15266
3.40E-36
15266
4.94E-52
15266
1.68E-39
15266
2.23E-39
15266
7.38E-43
15266
2.85E-24
15266
2.11E-38
15266
3.02E-40
15266
2.55E-41
15266
4.30E-35
15266
8.47E-42
15266
7.46E-39
15266
3.98E-35
15266
1.08E-65
15266
5.42E-46
13809
1.86E-36
14385
4.47E-31
15266
8.39E-34
15266
1.23E-39
13582
2.82E-40
15266
2.54E-35
15266
5.24E-26
15266
2.09E-31
15266
2.96E-33
15266
5.20E-44
15266
7.19E-46
13461
1.86E-22
15266
1.97E-46
15266
1.05E-36
15266
1.53E-40
15266
2.10E-39
15266
1.41E-28
15266
3.50E-37
15266
9.21E-30
15266
1.92E-31
15266
7.66E-48
14385
2.71E-27
15266
2.24E-27
15266
6.64E-27
15266
3.27E-33
15266
2.63E-30
15266
2.15E-22
15266
3.79E-43
15266
1.49E-25
14385
4.50E-34
15266
3.29E-29
15266
4.35E-29
15266
5.57E-29
15266
3.63E-35
15266
1.65E-25
15266
1.48E-35
15266
1.04E-24
15266
9.77E-33
15266
3.43E-28
15266
1.33E-18
13582
5.89E-33
15266
1.26E-39
15266
3.43E-20
14754
1.48E-24
15266
3.40E-24
15266
1.23E-32
15266
2.39E-39
14385
1.81E-21
15266
2.59E-29
15266
8.75E-29
15266
3.18E-24
15266
1.03E-19
15266
2.86E-28
15266
3.82E-30
15266
3.18E-38
15266
3.63E-47
15266
8.32E-28
15266
6.84E-19
15266
2.49E-27
15266
8.51E-35
15266
6.70E-34
15266
8.64E-28
15266
4.86E-36
15266
7.50E-26
15266
7.30E-33
15266
1.10E-25
15266
4.63E-20
14385
9.91E-24
15266
4.93E-38
15266
1.14E-23
15266
9.64E-23
15266
6.08E-24
15266
4.81E-19
15266
1.38E-37
15266
1.64E-38
15266
4.96E-24
15266
3.03E-25
15266
9.75E-27
15266
META: Zscore
-51.458
-44.381
-33.311
-31.562
-30.83
-30.407
28.068
-27.203
-27.147
-26.95
-26.335
-26.149
-25.954
25.857
-25.142
25.077
-25.046
-24.416
-24.357
-24.057
23.469
23.128
-22.78
-22.729
-22.711
-22.65
-22.391
-22.339
-21.97
21.945
-21.876
-21.681
-21.416
-21.29
-21.116
21.065
-21.013
-20.987
-20.779
20.431
-20.428
-20.185
-20.073
19.889
-19.873
-19.807
-19.702
-19.697
19.673
19.625
19.607
-19.558
19.431
-19.377
-19.32
-19.294
-19.05
18.949
-18.935
-18.902
-18.746
18.724
-18.722
-18.716
-18.708
-18.634
18.567
-18.524
18.425
-18.408
-18.393
-18.34
-18.301
-18.014
-17.989
-17.918
17.799
-17.793
-17.72
-17.613
17.597
17.568
17.541
17.533
17.488
-17.468
-17.389
-17.38
-17.358
-17.306
-17.27
-17.145
-17.081
-17.038
-17.037
-17.025
16.988
-16.988
-16.954
-16.93
16.911
16.909
16.897
-16.812
16.778
-16.761
16.644
-16.642
-16.622
-16.62
16.616
-16.561
-16.547
-16.532
16.494
-16.457
16.454
-16.367
-16.361
-16.355
-16.345
-16.32
-16.306
-16.265
16.257
16.25
-16.191
-16.126
-16.051
-16.03
-16.028
-16.027
-16.015
15.999
15.96
-15.92
-15.898
-15.898
15.854
15.831
-15.819
-15.81
-15.759
-15.744
-15.713
-15.684
-15.611
META:Direction
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
META: P
1.62e-577
3.53e-430
2.67E-243
1.22E-218
1.04E-208
4.41E-203
2.39E-173
5.96E-163
2.76E-162
5.68E-160
7.66E-153
1.00E-150
1.65E-148
2.03E-147
1.71E-139
8.82E-139
1.91E-138
1.16E-131
4.94E-131
6.98E-128
8.43E-122
2.41E-118
7.22E-115
2.34E-114
3.49E-114
1.41E-113
4.85E-111
1.55E-110
5.58E-107
9.70E-107
4.42E-106
3.13E-104
9.39E-102
1.42E-100
5.66E-99
1.67E-98
5.02E-98
8.61E-98
6.69E-96
8.94E-93
9.52E-93
1.31E-90
1.28E-89
5.11E-88
6.90E-88
2.58E-87
2.06E-86
2.31E-86
3.67E-86
9.40E-86
1.35E-85
3.50E-85
4.25E-84
1.21E-83
3.64E-83
6.02E-83
6.51E-81
4.50E-80
5.87E-80
1.10E-79
2.08E-78
3.18E-78
3.29E-78
3.64E-78
4.22E-78
1.70E-77
5.91E-77
1.33E-76
8.24E-76
1.13E-75
1.49E-75
3.94E-75
8.17E-75
1.51E-72
2.38E-72
8.47E-72
7.20E-71
7.95E-71
2.92E-70
1.95E-69
2.58E-69
4.32E-69
6.99E-69
8.01E-69
1.75E-68
2.53E-68
1.00E-67
1.16E-67
1.71E-67
4.20E-67
7.92E-67
6.80E-66
2.04E-65
4.29E-65
4.34E-65
5.37E-65
1.00E-64
1.01E-64
1.80E-64
2.71E-64
3.75E-64
3.88E-64
4.70E-64
2.01E-63
3.57E-63
4.68E-63
3.35E-62
3.48E-62
4.79E-62
4.95E-62
5.38E-62
1.33E-61
1.69E-61
2.17E-61
4.04E-61
7.47E-61
7.89E-61
3.29E-60
3.63E-60
4.02E-60
4.72E-60
7.13E-60
9.00E-60
1.74E-59
1.98E-59
2.22E-59
5.84E-59
1.67E-58
5.62E-58
7.86E-58
8.18E-58
8.21E-58
9.96E-58
1.30E-57
2.42E-57
4.61E-57
6.53E-57
6.54E-57
1.32E-56
1.91E-56
2.29E-56
2.63E-56
5.98E-56
7.58E-56
1.22E-55
1.95E-55
6.10E-55
Correlation-with-META:
-0.010
REPL-cerebellum Weight Effect
?
0
ns
+
394
0.005
394
-0.006
?
0
ns
?
0
ns
+
394
0.004
?
0
ns
?
0
ns
?
0
ns
+
394
0.003
394
-0.007
+
394
0.008
?
0
ns
?
0
ns
394
-0.002
394
-0.007
-0.002
394
?
0
ns
394
-0.005
?
0
ns
?
0
ns
+
394
0.001
+
394
0.001
?
0
ns
?
0
ns
?
0
ns
394
-0.003
394
-0.007
?
0
ns
?
0
ns
?
0
ns
394
0.000
+
394
0.001
394
-0.014
?
0
ns
?
0
ns
?
0
ns
394
-0.002
+
394
0.004
+
394
0.001
?
0
ns
394
-0.004
?
0
ns
?
0
ns
?
0
ns
+
394
0.009
394
-0.002
?
0
ns
?
0
ns
394
-0.008
?
0
ns
+
394
0.009
+
394
0.003
394
-0.004
?
0
ns
394
-0.010
+
394
0.007
?
0
ns
?
0
ns
?
0
ns
?
0
ns
?
0
ns
?
0
ns
+
394
0.000
?
0
ns
?
0
ns
+
394
0.009
?
0
ns
+
394
0.015
?
0
ns
+
394
0.005
+
394
0.014
394
-0.016
394
-0.003
?
0
ns
394
-0.002
+
394
0.003
+
394
0.005
?
0
ns
394
-0.008
394
-0.004
?
0
ns
?
0
ns
394
-0.002
?
0
ns
?
0
ns
394
-0.001
?
0
ns
+
394
0.000
?
0
ns
?
0
ns
394
-0.016
394
-0.005
+
394
0.006
+
394
0.005
?
0
ns
?
0
ns
?
0
ns
?
0
ns
394
-0.005
?
0
ns
?
0
ns
?
0
ns
?
0
ns
+
394
0.006
394
-0.011
+
394
0.002
+
394
0.001
?
0
ns
394
-0.010
?
0
ns
?
0
ns
394
-0.004
394
0.000
?
0
ns
?
0
ns
+
394
0.001
?
0
ns
394
-0.008
+
394
0.008
394
-0.015
+
394
0.000
394
0.000
+
394
0.000
?
0
ns
?
0
ns
?
0
ns
?
0
ns
?
0
ns
+
394
0.004
394
-0.016
394
-0.001
?
0
ns
394
-0.008
?
0
ns
?
0
ns
?
0
ns
+
394
0.002
394
-0.010
394
-0.003
?
0
ns
?
0
ns
+
394
0.007
?
0
ns
?
0
ns
+
394
0.009
394
-0.010
SE
ns
0.004
0.003
ns
ns
0.003
ns
ns
ns
0.004
0.003
0.004
ns
ns
0.004
0.003
0.003
ns
0.003
ns
ns
0.003
0.003
ns
ns
ns
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
0.003
ns
ns
ns
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
ns
ns
ns
ns
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.004
ns
ns
0.003
ns
0.004
ns
ns
0.003
0.003
0.003
0.003
ns
ns
ns
ns
0.003
ns
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.004
ns
ns
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
ns
ns
ns
0.003
0.003
0.003
ns
0.003
ns
ns
ns
0.003
0.003
0.004
ns
ns
0.003
ns
ns
0.003
0.003
P
ns
1.29E-01
6.23E-02
ns
ns
1.96E-01
ns
ns
ns
4.65E-01
2.31E-02
1.66E-02
ns
ns
6.08E-01
2.94E-02
5.55E-01
ns
9.10E-02
ns
ns
6.67E-01
8.18E-01
ns
ns
ns
3.91E-01
6.91E-03
ns
ns
ns
9.23E-01
8.20E-01
3.49E-06
ns
ns
ns
5.90E-01
2.45E-01
6.88E-01
ns
2.71E-01
ns
ns
ns
1.57E-03
6.21E-01
ns
ns
5.39E-03
ns
1.03E-02
2.80E-01
1.51E-01
ns
1.04E-04
2.99E-02
ns
ns
ns
ns
ns
ns
8.94E-01
ns
ns
5.64E-03
ns
1.47E-06
ns
9.09E-02
4.61E-07
1.16E-06
3.60E-01
ns
5.28E-01
4.12E-01
1.20E-01
ns
1.42E-02
1.99E-01
ns
ns
5.53E-01
ns
ns
7.12E-01
ns
9.04E-01
ns
ns
2.50E-06
1.31E-01
8.25E-02
1.25E-01
ns
ns
ns
ns
8.01E-02
ns
ns
ns
ns
7.77E-02
1.03E-03
5.33E-01
8.18E-01
ns
4.22E-03
ns
ns
2.05E-01
9.95E-01
ns
ns
7.44E-01
ns
1.59E-02
1.33E-02
5.73E-07
9.26E-01
9.35E-01
9.67E-01
ns
ns
ns
ns
ns
2.03E-01
6.99E-08
7.30E-01
ns
2.02E-02
ns
ns
ns
6.15E-01
4.03E-03
3.82E-01
ns
ns
3.97E-02
ns
ns
6.40E-03
6.33E-04
REPL-frontalcortex
Weight
?
0
394
394
?
0
?
0
+
394
?
0
?
0
?
0
+
394
394
394
+
394
?
0
?
0
394
394
?
0
+
394
?
0
?
0
+
394
394
394
?
0
?
0
+
394
394
?
0
?
0
?
0
+
394
+
394
394
?
0
?
0
?
0
394
?
0
+
394
?
0
+
394
394
?
0
?
0
+
394
+
394
?
0
?
0
394
?
0
+
394
?
0
+
394
?
0
394
+
394
+
394
?
0
?
0
?
0
?
0
?
0
394
?
0
?
0
+
394
?
0
394
394
394
+
+
394
+
394
394
?
0
394
+
394
+
394
?
0
394
394
?
0
?
0
+
394
?
0
?
0
+
394
?
0
+
394
?
0
?
0
394
394
+
394
?
0
?
0
?
0
?
0
?
0
394
?
0
?
0
?
0
?
0
+
394
394
+
394
+
394
394
394
?
0
?
0
394
394
?
0
?
0
+
394
?
0
394
+
394
+
394
+
394
+
394
?
0
+
394
394
?
0
?
0
?
0
+
394
394
+
394
?
0
394
?
0
?
0
?
0
394
+
394
+
394
?
0
?
0
+
394
?
0
?
0
+
394
394
0.080
Effect
ns
-0.008
-0.008
ns
ns
0.007
ns
ns
ns
0.012
-0.017
-0.009
0.008
ns
ns
-0.007
-0.002
ns
0.014
ns
ns
0.009
0.000
-0.011
ns
ns
0.013
-0.012
ns
ns
ns
0.006
0.014
-0.018
ns
ns
ns
-0.013
ns
0.006
ns
0.003
-0.014
ns
ns
0.015
0.004
ns
ns
-0.008
ns
0.004
ns
0.006
ns
-0.003
0.011
0.006
ns
ns
ns
ns
ns
0.000
ns
ns
0.002
ns
-0.009
-0.006
0.006
0.015
0.007
0.000
ns
-0.007
0.001
0.006
ns
-0.014
-0.002
ns
ns
0.004
ns
ns
0.006
ns
0.005
ns
ns
-0.007
-0.005
0.007
ns
ns
ns
ns
ns
-0.001
ns
ns
ns
ns
0.004
-0.007
0.004
0.005
-0.006
-0.016
ns
ns
-0.002
-0.005
ns
ns
0.007
ns
-0.007
0.003
0.002
0.001
0.007
ns
0.005
-0.011
ns
ns
ns
0.003
-0.014
0.001
ns
-0.007
ns
ns
ns
-0.018
0.005
0.009
ns
ns
0.010
ns
ns
0.003
-0.007
SE
ns
0.003
0.003
ns
ns
0.003
ns
ns
ns
0.004
0.003
0.004
0.003
ns
ns
0.003
0.004
ns
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
ns
ns
0.003
ns
0.003
ns
0.003
0.003
ns
ns
0.003
0.004
ns
ns
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
0.004
ns
ns
ns
ns
ns
0.003
ns
ns
0.003
ns
0.004
0.003
0.003
0.003
0.003
0.003
ns
0.004
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
ns
ns
0.003
ns
0.003
ns
ns
0.003
0.003
0.003
ns
ns
ns
ns
ns
0.003
ns
ns
ns
ns
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
0.003
ns
ns
ns
0.003
0.003
0.003
ns
ns
0.003
ns
ns
0.003
0.003
P
ns
1.89E-02
2.46E-02
ns
ns
3.67E-02
ns
ns
ns
9.15E-04
1.72E-06
1.52E-02
2.41E-03
ns
ns
2.48E-02
5.93E-01
ns
1.83E-05
ns
ns
2.22E-03
9.68E-01
1.31E-03
ns
ns
2.23E-04
1.56E-06
ns
ns
ns
1.03E-01
4.02E-06
4.37E-09
ns
ns
ns
7.26E-05
ns
4.10E-02
ns
3.72E-01
1.70E-06
ns
ns
2.65E-07
3.11E-01
ns
ns
1.13E-02
ns
1.82E-01
ns
6.50E-02
ns
1.90E-01
1.38E-03
7.84E-02
ns
ns
ns
ns
ns
9.86E-01
ns
ns
4.61E-01
ns
1.26E-02
6.75E-02
4.64E-02
6.01E-07
4.45E-02
8.92E-01
ns
5.90E-02
6.82E-01
8.54E-02
ns
1.20E-05
5.76E-01
ns
ns
2.59E-01
ns
ns
3.37E-02
ns
1.53E-01
ns
ns
4.12E-02
1.38E-01
1.97E-02
ns
ns
ns
ns
ns
7.96E-01
ns
ns
ns
ns
2.65E-01
5.31E-02
2.29E-01
9.84E-02
6.55E-02
3.55E-07
ns
ns
6.15E-01
1.01E-01
ns
ns
1.33E-02
ns
3.35E-02
3.28E-01
6.04E-01
7.55E-01
1.57E-02
ns
1.02E-01
6.90E-04
ns
ns
ns
4.13E-01
5.61E-05
6.34E-01
ns
2.28E-02
ns
ns
ns
3.43E-09
9.23E-02
9.98E-03
ns
ns
2.33E-03
ns
ns
2.63E-01
3.62E-02
REPL-CD4+
Weight
-515
?213
?213
?213
-515
-515
++
515
?213
-515
-515
-515
-515
-+
515
?+
213
?213
++
515
-515
-515
-515
-515
++
515
?+
213
-515
-515
-515
-515
-515
-515
+515
?+
213
-515
-515
-515
-515
?
0
++
515
-?
302
-515
-515
++
515
-515
-515
-515
++
515
-515
-515
-515
?213
++
515
++
515
++
515
-515
+?
302
+515
-515
-515
-515
+?
302
-515
-515
?213
++
515
-515
?213
?+
213
-+
515
+515
-515
?+
213
-+
515
-515
-+
515
?213
-515
-515
-515
++
515
-515
+515
?213
?+
213
++
515
++
515
++
515
++
515
-515
-+
515
++
515
-515
-+
515
++
515
-515
?213
-515
-515
?213
++
515
?+
213
-515
-515
+515
++
515
++
515
?
0
++
515
?213
?+
213
++
515
-515
-515
++
515
-515
+515
-515
++
515
-515
?213
-515
-515
-515
-515
+515
+515
-?
302
++
515
+515
+515
-+
515
-515
+515
-515
-515
-515
++
515
++
515
-?
302
-515
-+
515
++
515
++
515
-515
+515
-515
?+
213
++
515
-515
-515
0.671
Zscore
-3.445
-3.670
-0.219
-2.050
-5.730
-4.260
5.407
-1.314
-2.038
-3.835
-8.556
-5.047
-3.288
2.954
-2.231
5.127
-6.337
-3.835
-10.805
-2.629
4.147
4.089
-3.162
-3.169
-6.384
-1.392
-6.999
-1.967
0.496
3.681
-2.387
-2.215
-3.315
-3.756
ns
3.764
-2.646
-0.952
-1.535
4.002
-0.675
-2.619
-1.954
3.747
-3.414
-3.803
-1.011
-2.364
5.414
6.609
4.007
-3.210
2.605
-0.784
-3.215
-6.077
-3.146
2.881
-4.362
-0.868
-0.430
4.108
-2.137
-1.717
0.341
-0.814
1.060
-3.212
2.430
-0.404
-2.006
0.190
-4.970
-3.709
-4.582
-1.671
7.686
-2.745
-1.075
-4.086
0.421
8.156
2.024
4.323
8.438
-1.876
-0.242
0.926
-3.201
-0.902
0.499
-2.796
-2.143
-5.129
-3.112
-3.494
5.067
2.063
-3.148
-3.220
0.514
4.658
4.232
ns
2.691
-0.150
2.847
0.747
-5.059
-4.711
3.811
-1.459
-0.252
-3.164
5.096
-4.513
-0.695
-2.081
-1.324
-2.511
-1.012
-0.488
-0.779
-3.070
7.836
1.220
0.322
-0.242
-2.435
0.088
-2.136
-3.464
-2.575
5.346
2.574
-0.622
-1.106
-2.063
3.166
1.259
-2.549
-0.803
-1.601
0.919
1.423
-1.011
-1.178
P
5.70E-04
2.43E-04
8.27E-01
4.04E-02
1.01E-08
2.05E-05
6.41E-08
1.89E-01
4.16E-02
1.26E-04
1.17E-17
4.48E-07
1.01E-03
3.14E-03
2.57E-02
2.95E-07
2.34E-10
1.26E-04
3.27E-27
8.57E-03
3.37E-05
4.33E-05
1.57E-03
1.53E-03
1.73E-10
1.64E-01
2.58E-12
4.92E-02
6.20E-01
2.32E-04
1.70E-02
2.68E-02
9.16E-04
1.72E-04
ns
1.67E-04
8.14E-03
3.41E-01
1.25E-01
6.28E-05
5.00E-01
8.82E-03
5.08E-02
1.79E-04
6.40E-04
1.43E-04
3.12E-01
1.81E-02
6.15E-08
3.87E-11
6.16E-05
1.33E-03
9.19E-03
4.33E-01
1.30E-03
1.22E-09
1.66E-03
3.96E-03
1.29E-05
3.85E-01
6.67E-01
4.00E-05
3.26E-02
8.60E-02
7.33E-01
4.16E-01
2.89E-01
1.32E-03
1.51E-02
6.86E-01
4.48E-02
8.50E-01
6.69E-07
2.08E-04
4.62E-06
9.47E-02
1.52E-14
6.05E-03
2.82E-01
4.39E-05
6.74E-01
3.46E-16
4.29E-02
1.54E-05
3.22E-17
6.06E-02
8.09E-01
3.55E-01
1.37E-03
3.67E-01
6.18E-01
5.17E-03
3.21E-02
2.92E-07
1.86E-03
4.75E-04
4.05E-07
3.91E-02
1.65E-03
1.28E-03
6.07E-01
3.20E-06
2.31E-05
ns
7.13E-03
8.81E-01
4.42E-03
4.55E-01
4.21E-07
2.46E-06
1.38E-04
1.45E-01
8.01E-01
1.56E-03
3.47E-07
6.38E-06
4.87E-01
3.74E-02
1.86E-01
1.20E-02
3.11E-01
6.26E-01
4.36E-01
2.14E-03
4.65E-15
2.23E-01
7.47E-01
8.09E-01
1.49E-02
9.30E-01
3.27E-02
5.32E-04
1.00E-02
8.98E-08
1.01E-02
5.34E-01
2.69E-01
3.91E-02
1.54E-03
2.08E-01
1.08E-02
4.22E-01
1.09E-01
3.58E-01
1.55E-01
3.12E-01
2.39E-01
Correlation-with-META: 0.782
REPL-CD8+
Weight
Effect
299
-0.044
?
0
ns
?
0
ns
?
0
ns
299
-0.088
299
-0.063
+
299
0.076
?
0
ns
299
-0.051
299
-0.053
299
-0.028
299
-0.016
299
-0.084
?
0
ns
?
0
ns
+
299
0.038
299
-0.051
299
-0.005
299
-0.049
299
-0.024
+
299
0.052
?
0
ns
299
-0.023
299
-0.020
299
-0.007
299
-0.044
299
-0.058
299
-0.036
299
-0.017
?
0
ns
299
-0.034
299
-0.034
299
-0.028
299
-0.039
?
0
ns
+
299
0.013
299
-0.053
299
-0.036
299
-0.028
+
299
0.025
299
-0.030
299
-0.046
299
-0.017
+
299
0.036
299
-0.035
299
-0.033
299
-0.036
?
0
ns
+
299
0.042
+
299
0.039
+
299
0.064
299
-0.051
+
299
0.041
299
-0.032
299
-0.035
299
-0.039
299
-0.023
+
299
0.017
299
-0.044
299
-0.026
?
0
ns
+
299
0.032
299
-0.054
?
0
ns
?
0
ns
299
-0.018
+
299
0.028
299
-0.014
+
299
0.011
299
-0.035
299
-0.009
299
-0.044
299
-0.005
299
-0.056
299
-0.017
299
-0.013
+
299
0.060
299
-0.045
299
-0.005
?
0
ns
?
0
ns
299
-0.001
+
299
0.010
+
299
0.033
+
299
0.030
299
-0.037
299
-0.029
299
-0.032
299
-0.004
299
-0.003
299
-0.012
299
-0.009
?
0
ns
299
-0.054
299
-0.049
?
0
ns
+
299
0.046
?
0
ns
299
-0.048
299
-0.031
+
299
0.014
+
299
0.014
+
299
0.027
?
0
ns
+
299
0.023
?
0
ns
?
0
ns
299
-0.013
299
-0.027
299
-0.011
+
299
0.014
299
-0.018
299
-0.001
299
-0.022
+
299
0.038
299
-0.034
+
299
0.022
299
-0.019
299
0.000
299
-0.014
299
-0.022
299
-0.002
299
-0.012
299
-0.047
+
299
0.019
+
299
0.027
299
-0.005
299
-0.008
299
-0.002
299
-0.024
299
-0.012
299
-0.028
+
299
0.000
+
299
0.026
+
299
0.042
299
-0.003
299
-0.020
299
-0.035
+
299
0.028
299
-0.004
299
-0.018
299
-0.033
299
-0.028
?
0
ns
299
-0.015
299
-0.007
299
-0.027
SE
0.005
ns
ns
ns
0.010
0.007
0.015
ns
0.008
0.008
0.005
0.003
0.012
ns
ns
0.007
0.008
0.002
0.006
0.005
0.019
ns
0.005
0.005
0.003
0.007
0.007
0.007
0.004
ns
0.007
0.008
0.005
0.006
ns
0.005
0.008
0.010
0.006
0.007
0.009
0.007
0.007
0.011
0.006
0.007
0.009
ns
0.012
0.009
0.016
0.007
0.009
0.005
0.007
0.005
0.004
0.007
0.007
0.012
ns
0.008
0.013
ns
ns
0.003
0.008
0.007
0.005
0.009
0.006
0.009
0.002
0.008
0.003
0.004
0.008
0.007
0.007
ns
ns
0.005
0.003
0.011
0.006
0.009
0.006
0.006
0.003
0.006
0.006
0.002
ns
0.007
0.007
ns
0.009
ns
0.007
0.009
0.006
0.004
0.010
ns
0.005
ns
ns
0.005
0.004
0.002
0.004
0.007
0.003
0.005
0.013
0.009
0.006
0.004
0.002
0.004
0.006
0.003
0.004
0.007
0.004
0.006
0.005
0.003
0.002
0.005
0.003
0.005
0.002
0.007
0.011
0.002
0.004
0.005
0.010
0.004
0.005
0.009
0.006
ns
0.003
0.012
0.005
P
2.44E-16
ns
ns
ns
2.97E-15
2.59E-16
1.39E-06
ns
1.34E-10
1.04E-10
3.04E-09
4.29E-09
6.39E-12
ns
ns
1.93E-08
1.74E-10
5.89E-03
2.29E-14
1.95E-06
5.50E-03
ns
3.20E-05
5.04E-05
2.37E-02
7.74E-10
1.81E-15
4.94E-07
5.22E-05
ns
6.56E-06
2.05E-05
2.85E-08
1.77E-10
ns
6.07E-03
4.62E-10
5.59E-04
9.82E-07
1.57E-04
7.56E-04
5.46E-10
2.30E-02
9.12E-04
3.64E-09
3.33E-06
4.91E-05
ns
5.52E-04
3.44E-05
5.70E-05
4.12E-12
1.13E-05
7.19E-09
1.74E-06
3.18E-13
1.35E-07
1.30E-02
2.70E-10
3.19E-02
ns
3.81E-05
7.41E-05
ns
ns
1.14E-07
1.11E-03
6.54E-02
3.05E-02
1.62E-04
1.32E-01
1.92E-06
1.58E-02
1.64E-10
6.07E-07
2.26E-03
2.87E-12
3.71E-10
4.71E-01
ns
ns
8.65E-01
1.07E-04
2.11E-03
6.87E-07
3.79E-05
6.40E-06
6.06E-07
2.20E-01
5.93E-01
3.90E-02
1.25E-04
ns
4.12E-12
3.35E-12
ns
1.13E-06
ns
1.47E-10
6.38E-04
2.02E-02
6.54E-04
8.80E-03
ns
5.43E-06
ns
ns
1.16E-02
7.31E-12
4.30E-07
7.18E-04
7.72E-03
6.20E-01
4.80E-06
3.89E-03
3.44E-04
1.52E-04
3.16E-05
8.63E-01
6.08E-04
1.99E-04
5.34E-01
1.53E-03
1.16E-09
6.22E-07
7.23E-06
3.70E-01
1.03E-02
3.36E-01
3.49E-06
5.90E-05
1.92E-07
8.05E-01
4.61E-04
2.60E-04
2.70E-01
3.85E-06
1.26E-11
5.13E-03
4.02E-01
1.83E-04
1.59E-04
1.30E-05
ns
1.48E-05
5.48E-01
1.54E-07
REPL-CD14+/monocytes
+?
----+++
-+
-+++?
++
++
+-+
+?
+?
++
+++
++-+
+-+-++-+-+
-?-?+
-+
-++
+-+
++++
-++
+?
++++
-+
?-+
-+
--?+
--+++-++++
++?
+-++++
+++++
+?
-+?
-+
+?
-+
++
-+
-+++--+-+
+-?
++---+
++
++
?++
++
++
++
+?
++
-+
--+++
+++
-+-?
-+
--+
?+-++?
+-+
--+
-++
+?
+?
+-+
++
++
-+
++
++++
--
Weight
213
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
213
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
354
567
354
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
354
567
567
567
567
354
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
213
567
213
567
213
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
354
567
567
567
567
213
567
567
567
567
567
567
567
567
567
567
213
567
567
567
354
567
567
567
213
567
567
567
567
567
567
567
0
213
567
567
567
567
567
567
567
567
567
567
0.426
Zscore
2.801
-3.745
-1.806
-1.727
-2.632
-1.900
2.202
-1.164
-1.596
-0.207
0.462
0.895
1.495
3.427
-1.020
2.896
0.640
0.388
2.727
-0.416
2.451
1.513
-1.945
-0.203
-1.029
-2.211
0.498
-2.784
0.188
1.148
-1.615
-1.045
-1.750
-5.551
-2.108
-2.337
0.071
-1.084
-0.649
0.870
-1.023
0.003
-1.252
1.588
0.837
-1.421
2.447
1.684
1.629
0.596
1.958
0.911
-1.433
1.062
0.060
-2.999
-3.275
0.813
-2.671
-2.514
0.250
0.030
-0.703
-2.093
-0.355
-0.680
0.886
-1.396
3.050
-0.361
-2.375
0.991
-1.426
1.346
0.337
-0.562
-1.559
1.032
3.070
-2.749
2.432
-0.379
1.129
1.517
3.843
1.863
-1.169
-0.208
-0.326
0.855
-0.823
-1.536
-1.185
1.569
-0.184
-0.478
-0.058
-2.228
-1.437
-4.551
2.155
2.040
1.943
-0.948
2.126
1.593
1.552
3.060
1.920
0.317
-1.362
-2.527
-2.156
-1.207
1.808
-2.068
1.440
-2.228
-0.933
-0.507
-1.230
-1.037
-1.192
-0.189
0.222
-0.957
-1.545
1.663
-0.138
0.210
-0.602
-1.282
-0.865
3.098
1.288
ns
0.537
-0.896
0.829
2.649
0.977
0.898
1.321
0.295
-1.109
1.788
-3.540
P
5.09E-03
1.80E-04
7.09E-02
8.42E-02
8.48E-03
5.74E-02
2.77E-02
2.45E-01
1.11E-01
8.36E-01
6.44E-01
3.71E-01
1.35E-01
6.11E-04
3.08E-01
3.78E-03
5.22E-01
6.98E-01
6.39E-03
6.78E-01
1.43E-02
1.30E-01
5.18E-02
8.39E-01
3.04E-01
2.71E-02
6.18E-01
5.37E-03
8.51E-01
2.51E-01
1.06E-01
2.96E-01
8.01E-02
2.84E-08
3.50E-02
1.94E-02
9.43E-01
2.78E-01
5.16E-01
3.84E-01
3.06E-01
9.97E-01
2.11E-01
1.12E-01
4.03E-01
1.55E-01
1.44E-02
9.21E-02
1.03E-01
5.51E-01
5.02E-02
3.62E-01
1.52E-01
2.88E-01
9.52E-01
2.71E-03
1.06E-03
4.16E-01
7.57E-03
1.19E-02
8.03E-01
9.76E-01
4.82E-01
3.64E-02
7.23E-01
4.97E-01
3.75E-01
1.63E-01
2.29E-03
7.18E-01
1.76E-02
3.22E-01
1.54E-01
1.78E-01
7.37E-01
5.74E-01
1.19E-01
3.02E-01
2.14E-03
5.98E-03
1.50E-02
7.05E-01
2.59E-01
1.29E-01
1.21E-04
6.25E-02
2.42E-01
8.35E-01
7.45E-01
3.92E-01
4.11E-01
1.24E-01
2.36E-01
1.17E-01
8.54E-01
6.33E-01
9.54E-01
2.59E-02
1.51E-01
5.33E-06
3.11E-02
4.14E-02
5.20E-02
3.43E-01
3.35E-02
1.11E-01
1.21E-01
2.21E-03
5.48E-02
7.51E-01
1.73E-01
1.15E-02
3.11E-02
2.27E-01
7.06E-02
3.87E-02
1.50E-01
2.59E-02
3.51E-01
6.12E-01
2.19E-01
3.00E-01
2.33E-01
8.50E-01
8.25E-01
3.39E-01
1.22E-01
9.64E-02
8.91E-01
8.34E-01
5.47E-01
2.00E-01
3.87E-01
1.95E-03
1.98E-01
ns
5.91E-01
3.70E-01
4.07E-01
8.08E-03
3.29E-01
3.69E-01
1.87E-01
7.68E-01
2.67E-01
7.38E-02
4.01E-04
Correlation-with-META -0.006
REPL-LCLs
Weight
Effect
869
0.000
869
-0.001
?
0
ns
+
869
0.003
869
-0.004
869
-0.003
?
0
ns
869
-0.005
+
869
0.001
869
-0.003
869
-0.001
+
869
0.011
869
0.000
869
-0.001
869
-0.001
869
-0.001
869
-0.005
+
869
0.002
869
-0.003
869
-0.001
?
0
ns
+
869
0.002
+
869
0.001
+
869
0.003
869
-0.012
0.000
869
869
0.000
+
869
0.003
869
-0.004
+
869
0.000
+
869
0.001
869
0.000
+
869
0.003
+
869
0.006
?
0
ns
+
869
0.000
869
-0.006
869
-0.001
+
869
0.006
869
-0.001
869
-0.001
869
-0.001
869
-0.007
?
0
ns
869
-0.002
869
-0.002
+
869
0.001
+
869
0.001
+
869
0.001
869
0.000
?
0
ns
+
869
0.002
?
0
ns
869
0.000
869
-0.001
869
-0.002
+
869
0.001
?
0
ns
?
0
ns
869
0.000
869
-0.003
869
0.000
+
869
0.000
869
-0.001
+
869
0.001
869
-0.008
?
0
ns
869
-0.004
869
-0.002
?
0
ns
869
-0.009
869
-0.001
+
869
0.005
?
0
ns
?
0
ns
?
0
ns
869
-0.003
+
869
0.001
?
0
ns
+
869
0.006
?
0
ns
+
869
0.000
?
0
ns
+
869
0.010
869
-0.001
869
-0.003
+
869
0.002
+
869
0.005
?
0
ns
+
869
0.002
869
-0.005
+
869
0.002
+
869
0.000
+
869
0.001
+
869
0.002
869
-0.001
869
-0.004
869
-0.001
+
869
0.004
+
869
0.002
+
869
0.003
+
869
0.002
869
0.000
+
869
0.002
869
0.000
869
-0.004
869
-0.001
+
869
0.001
+
869
0.000
869
-0.006
869
-0.001
869
-0.003
869
-0.001
+
869
0.002
?
0
ns
869
-0.001
869
0.000
869
-0.002
869
0.000
869
-0.001
869
-0.003
+
869
0.005
+
869
0.003
?
0
ns
?
0
ns
869
0.000
869
-0.007
869
0.000
+
869
0.000
?
0
ns
+
869
0.000
869
-0.003
869
-0.008
869
-0.004
?
0
ns
?
0
ns
+
869
0.000
+
869
0.001
869
-0.005
869
-0.003
869
-0.003
+
869
0.001
869
-0.001
+
869
0.001
869
-0.001
869
-0.002
+
869
0.001
SE
0.001
0.001
ns
0.003
0.003
0.002
ns
0.001
0.002
0.002
0.001
0.003
0.000
0.001
0.001
0.001
0.001
0.001
0.002
0.003
ns
0.003
0.001
0.001
0.003
0.002
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.002
ns
0.001
0.003
0.001
0.001
0.001
0.001
0.001
0.002
ns
0.001
0.001
0.002
0.001
0.001
0.000
ns
0.001
ns
0.001
0.002
0.002
0.001
ns
ns
0.001
0.001
0.001
0.001
0.001
0.002
0.002
ns
0.003
0.001
ns
0.002
0.001
0.003
ns
ns
ns
0.002
0.001
ns
0.002
ns
0.001
ns
0.005
0.002
0.001
0.002
0.001
ns
0.001
0.003
0.001
0.001
0.001
0.001
0.002
0.001
0.002
0.001
0.001
0.002
0.003
0.001
0.001
0.000
0.002
0.002
0.001
0.000
0.002
0.002
0.002
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.003
0.002
0.002
0.001
ns
ns
0.001
0.002
0.001
0.001
ns
0.001
0.001
0.004
0.001
ns
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
P
9.87E-01
1.52E-01
ns
3.10E-01
1.43E-01
6.60E-02
ns
4.87E-04
7.61E-01
5.62E-02
5.78E-01
5.13E-05
8.47E-01
2.68E-01
5.33E-02
3.55E-01
8.23E-07
8.03E-02
1.63E-01
7.76E-01
ns
4.32E-01
2.50E-01
1.43E-02
2.19E-04
8.93E-01
9.14E-01
6.73E-03
4.84E-03
8.67E-01
6.25E-01
8.09E-01
3.58E-04
6.52E-03
ns
7.58E-01
4.99E-02
3.00E-01
7.59E-07
4.36E-01
5.02E-01
6.33E-01
1.69E-05
ns
1.80E-01
3.49E-02
4.57E-01
3.74E-01
2.59E-01
4.14E-01
ns
1.63E-02
ns
7.92E-01
5.19E-01
4.37E-01
3.14E-01
ns
ns
8.72E-01
3.07E-05
9.59E-01
9.29E-01
4.80E-01
5.95E-01
6.14E-04
ns
1.85E-01
1.17E-01
ns
6.71E-06
2.25E-01
9.47E-02
ns
ns
ns
1.21E-01
4.67E-01
ns
9.89E-03
ns
9.54E-01
ns
4.51E-02
4.13E-01
4.80E-02
2.93E-01
1.62E-03
ns
2.92E-01
8.21E-02
2.56E-03
7.90E-01
3.95E-01
2.39E-01
6.46E-01
1.39E-03
7.02E-01
7.93E-03
2.03E-02
8.55E-02
5.09E-01
5.48E-01
6.33E-02
5.52E-01
5.04E-02
5.15E-01
1.87E-02
5.20E-01
7.85E-03
5.10E-01
8.85E-02
2.01E-01
1.79E-02
ns
2.32E-01
9.91E-01
1.96E-01
9.09E-01
6.37E-01
1.46E-01
1.26E-03
3.75E-04
ns
ns
9.27E-01
1.97E-03
5.40E-01
7.14E-01
ns
7.79E-01
6.02E-03
3.34E-02
4.77E-03
ns
ns
8.17E-01
3.58E-01
7.62E-04
1.66E-02
1.28E-02
3.20E-01
2.03E-01
3.50E-01
2.47E-01
4.66E-02
1.73E-01
REPL-LYMPHOCYTES
Weight
?
0
?
0
1244
1244
1244
?
0
?
0
?
0
?
0
?
0
?
0
1244
?
0
?
0
1244
+
1244
?
0
1244
1244
1244
+
1244
?
0
?
0
1244
?
0
1244
1244
?
0
?
0
?
0
1244
1244
?
0
1244
1244
?
0
?
0
?
0
?
0
?
0
?
0
?
0
?
0
?
0
1244
?
0
1244
1244
?
0
?
0
+
1244
?
0
+
1244
?
0
?
0
?
0
1244
?
0
1244
?
0
1244
?
0
?
0
1244
1244
?
0
?
0
1244
?
0
?
0
1244
?
0
1244
?
0
?
0
1244
?
0
1244
?
0
?
0
?
0
?
0
?
0
+
1244
+
1244
?
0
1244
1244
?
0
?
0
?
0
1244
?
0
?
0
?
0
1244
?
0
?
0
?
0
1244
?
0
?
0
?
0
1244
?
0
?
0
?
0
?
0
?
0
?
0
+
1244
1244
?
0
?
0
+
1244
?
0
?
0
1244
?
0
?
0
?
0
?
0
1244
1244
?
0
?
0
1244
?
0
?
0
?
0
1244
?
0
?
0
?
0
?
0
?
0
?
0
1244
+
1244
+
1244
1244
?
0
?
0
1244
?
0
?
0
1244
0.784
Effect
ns
ns
-0.009
-0.012
-0.013
ns
ns
ns
ns
ns
ns
0.000
ns
ns
-0.003
0.007
ns
-0.001
-0.004
-0.004
0.010
ns
ns
-0.005
ns
-0.006
-0.005
ns
ns
ns
-0.001
-0.007
ns
-0.003
-0.006
ns
ns
ns
ns
ns
ns
ns
ns
ns
-0.004
ns
-0.005
-0.003
ns
ns
0.006
ns
0.005
ns
ns
ns
-0.003
ns
-0.010
ns
-0.005
ns
ns
-0.002
-0.002
ns
ns
-0.012
ns
ns
-0.003
ns
-0.001
ns
ns
-0.002
ns
-0.003
ns
ns
ns
ns
ns
0.005
0.003
ns
-0.001
-0.006
ns
ns
ns
-0.002
ns
ns
ns
-0.002
ns
ns
ns
-0.005
ns
ns
ns
-0.002
ns
ns
ns
ns
ns
ns
0.002
-0.003
ns
ns
0.006
ns
ns
-0.001
ns
ns
ns
ns
-0.003
-0.004
ns
ns
-0.002
ns
ns
ns
-0.003
ns
ns
ns
ns
ns
ns
-0.004
0.002
0.004
-0.003
ns
ns
-0.003
ns
ns
-0.002
SE
ns
ns
0.001
0.001
0.001
ns
ns
ns
ns
ns
ns
0.000
ns
ns
0.000
0.000
ns
0.000
0.000
0.000
0.001
ns
ns
0.001
ns
0.001
0.000
ns
ns
ns
0.000
0.001
ns
0.000
0.000
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.000
ns
0.001
0.000
ns
ns
0.001
ns
0.001
ns
ns
ns
0.001
ns
0.001
ns
0.000
ns
ns
0.000
0.001
ns
ns
0.002
ns
ns
0.000
ns
0.000
ns
ns
0.000
ns
0.000
ns
ns
ns
ns
ns
0.001
0.000
ns
0.000
0.001
ns
ns
ns
0.000
ns
ns
ns
0.000
ns
ns
ns
0.001
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
0.000
0.001
ns
ns
0.001
ns
ns
0.000
ns
ns
ns
ns
0.000
0.000
ns
ns
0.000
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
0.000
0.001
0.001
0.000
ns
ns
0.001
ns
ns
0.001
P
ns
ns
1.58E-24
5.84E-32
1.47E-40
ns
ns
ns
ns
ns
ns
2.96E-01
ns
ns
4.89E-17
3.02E-69
ns
3.86E-15
4.25E-40
1.92E-22
2.53E-17
ns
ns
9.87E-22
ns
2.42E-13
8.10E-32
ns
ns
ns
9.83E-08
1.68E-27
ns
2.12E-16
1.17E-31
ns
ns
ns
ns
ns
ns
ns
ns
ns
7.06E-20
ns
1.13E-19
1.64E-22
ns
ns
8.46E-11
ns
5.82E-16
ns
ns
ns
2.57E-06
ns
3.00E-35
ns
4.41E-33
ns
ns
3.67E-04
3.04E-05
ns
ns
5.39E-14
ns
ns
3.44E-11
ns
3.08E-04
ns
ns
1.32E-10
ns
1.52E-15
ns
ns
ns
ns
ns
9.72E-08
5.87E-31
ns
2.19E-03
1.29E-16
ns
ns
ns
5.27E-18
ns
ns
ns
3.80E-12
ns
ns
ns
1.95E-12
ns
ns
ns
5.62E-07
ns
ns
ns
ns
ns
ns
4.24E-13
1.07E-07
ns
ns
5.35E-08
ns
ns
8.02E-06
ns
ns
ns
ns
2.35E-11
2.82E-17
ns
ns
7.43E-05
ns
ns
ns
4.61E-11
ns
ns
ns
ns
ns
ns
8.06E-29
8.18E-03
4.60E-17
1.30E-45
ns
ns
3.66E-07
ns
ns
1.44E-03
REPL-PBMCs
Weight
-?
134
-362
-362
-362
-362
-362
++
362
-362
-362
-362
-?
134
-?
134
-362
++
362
-362
++
362
-?
134
-362
-362
-362
++
362
++
362
-362
-362
-362
-362
-?
134
-+
362
-362
+?
134
-362
-362
-362
-362
-?
134
++
362
-362
-362
-362
++
362
-+
362
-362
-362
++
362
-362
-362
134
-?
-?
134
++
362
++
362
++
362
-362
+?
134
-362
-362
-362
-+
362
+?
134
-362
-+
362
-+
362
++
362
++
362
-362
+362
-362
++
362
-362
++
362
-+
362
-362
-362
-?
134
-+
362
-362
-?
134
++
362
-362
-362
-362
+?
134
+?
134
++
362
-+
362
+?
134
-362
-+
362
-362
-362
-?
134
++
362
-362
-362
-+
362
-362
-362
-+
362
+362
-362
-+
362
+362
++
362
++
362
-362
++
362
-?
134
++
362
-+
362
-?
134
-?
134
-+
362
-362
-362
-+
362
++
362
-362
+?
134
-+
362
-362
-362
-+
362
-?
134
++
362
-?
134
+?
134
++
362
-+
362
-?
134
-?
134
-362
-362
-362
-362
++
362
++
362
-?
134
-?
134
-+
362
++
362
0+
362
-?
134
-362
-362
-362
-?
134
-362
-+
362
0.595
Zscore
-5.295
-5.080
-3.175
-3.216
-2.964
-3.205
1.598
-2.543
-1.393
-3.238
-1.369
-3.494
-3.102
1.701
-2.616
3.070
-3.295
-2.648
-2.667
-2.822
2.014
3.276
-3.707
-5.918
-3.800
-2.214
-2.059
-1.503
-1.365
0.155
-2.776
-2.515
-2.697
-2.554
-3.076
0.023
-2.455
-2.038
-2.466
3.000
-0.290
-2.347
-1.310
3.085
-1.052
-3.148
-2.644
-1.567
1.882
2.957
2.434
-3.938
0.011
-1.094
-2.220
-3.672
-0.991
0.004
-3.372
-0.982
-1.514
1.262
1.518
-1.895
-1.145
-1.297
0.046
-5.088
2.523
-0.863
-2.933
-3.628
-1.893
-0.085
-1.612
-3.470
1.289
-2.944
-2.093
-2.411
0.038
0.548
2.176
0.866
0.014
-1.674
-0.458
-2.818
-2.834
-1.906
0.782
-2.380
-2.530
-1.394
-2.103
-1.969
0.212
0.098
-1.268
-0.231
-0.385
2.095
1.551
-2.365
2.930
-1.227
0.892
0.177
-2.974
-1.443
0.280
-2.254
-1.526
-0.804
1.849
-1.746
0.316
0.160
-1.197
-2.807
-0.679
-3.171
0.618
-1.937
0.097
0.739
0.661
-1.262
-3.169
-1.755
-3.909
-3.090
-3.179
1.957
1.474
-0.872
-1.708
-0.176
1.048
0.665
-2.722
-3.917
-4.049
-3.333
-1.635
-2.658
-0.860
P
1.19E-07
3.77E-07
1.50E-03
1.30E-03
3.04E-03
1.35E-03
1.10E-01
1.10E-02
1.64E-01
1.21E-03
1.71E-01
4.75E-04
1.92E-03
8.89E-02
8.90E-03
2.14E-03
9.83E-04
8.10E-03
7.64E-03
4.77E-03
4.40E-02
1.05E-03
2.10E-04
3.27E-09
1.45E-04
2.69E-02
3.95E-02
1.33E-01
1.72E-01
8.77E-01
5.51E-03
1.19E-02
6.99E-03
1.07E-02
2.10E-03
9.82E-01
1.41E-02
4.15E-02
1.37E-02
2.70E-03
7.72E-01
1.90E-02
1.90E-01
2.04E-03
2.93E-01
1.65E-03
8.20E-03
1.17E-01
5.99E-02
3.10E-03
1.49E-02
8.22E-05
9.91E-01
2.74E-01
2.64E-02
2.40E-04
3.22E-01
9.97E-01
7.45E-04
3.26E-01
1.30E-01
2.07E-01
1.29E-01
5.81E-02
2.52E-01
1.95E-01
9.63E-01
3.61E-07
1.16E-02
3.88E-01
3.36E-03
2.85E-04
5.83E-02
9.32E-01
1.07E-01
5.20E-04
1.97E-01
3.24E-03
3.63E-02
1.59E-02
9.70E-01
5.84E-01
2.96E-02
3.86E-01
9.89E-01
9.41E-02
6.47E-01
4.83E-03
4.60E-03
5.66E-02
4.34E-01
1.73E-02
1.14E-02
1.63E-01
3.55E-02
4.90E-02
8.32E-01
9.22E-01
2.05E-01
8.17E-01
7.00E-01
3.62E-02
1.21E-01
1.80E-02
3.39E-03
2.20E-01
3.73E-01
8.59E-01
2.94E-03
1.49E-01
7.79E-01
2.42E-02
1.27E-01
4.22E-01
6.45E-02
8.08E-02
7.52E-01
8.73E-01
2.31E-01
5.00E-03
4.97E-01
1.52E-03
5.37E-01
5.28E-02
9.23E-01
4.60E-01
5.09E-01
2.07E-01
1.53E-03
7.92E-02
9.27E-05
2.00E-03
1.48E-03
5.04E-02
1.41E-01
3.83E-01
8.77E-02
8.60E-01
2.95E-01
5.06E-01
6.48E-03
8.98E-05
5.15E-05
8.59E-04
1.02E-01
7.86E-03
3.90E-01
47999
45466
27057
13799
32865
11524
27661
63731
50693
40233
19773
50205
9609
254
2821
21203
22833
7399
61382
62711
24257
48610
14243
28979
34299
27404
8838
49640
2593
26063
28469
51527
10566
58592
5165
23124
26019
13352
23353
64858
59914
33986
22538
32859
7116
38506
2031
66460
43213
363
51598
31028
5427
19269
64319
29173
42095
29309
17255
2348
64385
26511
20216
5669
34237
36657
7670
26585
60212
39553
67858
16745
33100
41747
21366
51172
221
15527
10869
39404
48989
58213
37032
37329
18502
58674
7195
13143
31335
21941
19004
13064
20421
17114
26715
4198
17572
21689
5533
12708
30643
42098
9250
52690
54502
5148
2286
24145
66141
42689
1764
62641
52261
51427
59888
40664
3779
51956
38334
34224
60478
63583
34018
63830
37076
30484
18628
6280
39659
27806
11246
8378
3104
25914
61285
28295
61015
9449
23345
10341
25753
37702
51772
28312
24533
34294
65533
63561
369
7178
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
4054
5335
3490
3655
2153
27087
79652
10225
1462
23212
10808
27244
1396
9882
389289
84868
924
3925
10578
328
29851
256356
10055
2323
2064
149628
51314
10144
56937
51735
54680
23178
56895
2040
28951
79026
51202
55536
6281
2788
50628
7188
916
125875
643
2199
9060
9781
8462
353345
933
81030
1123
91607
51744
3611
8530
26289
5730
1968
3329
9093
81567
51348
5166
10316
55653
3376
50854
26156
7423
5729
55272
23157
59352
9533
5324
8313
7267
7694
199786
9806
1266
90594
57504
84417
115362
114915
1942
8553
60489
10172
4026
128346
57185
5027
56915
788
139716
85315
55556
3646
3543
8320
54881
9500
7071
53347
6711
9788
3298
5778
23370
10131
128553
8667
6645
162972
53335
1495
3111
3587
7184
6319
64425
6638
6272
158
51520
6856
5732
81539
84916
23708
83464
1875
256987
51386
91782
64757
1662
8270
3688
84128
55013
5198
84293
91151
5569
970
LTBP3
PLCG1
IGFBP7
ITGA6
F5
B3GAT1
TMEM204
CD96
VCAN
RRS1
HSPH1
SESN1
CRIP1
TBC1D4
ANXA2R
HAVCR2
CD7
STMN1
GNLY
APEX1
ICOS
GK5
SAE1
FLT3LG
ERBB2
PYHIN1
NME8
FAM13A
PMEPA1
RAPGEF6
ZNHIT6
PASK
AGPAT4
STOM
TRIB2
AHNAK
DDX47
CDCA7L
S100A10
GNG7
GEMIN4
TRAF5
CD3E
CLDND2
CXCR5
FBLN2
PAPSS2
RNF144A
KLF11
GPR141
CD22
ZBP1
CHN1
SLFN11
CD244
ILK
CST7
AK5
PTGDS
EIF2S3
HSPD1
DNAJA3
TXNDC5
KLRF1
PDK4
NMUR1
BCAS4
IARS
C6orf48
RSL1D1
VEGFB
PTGDR
IMP3
SEPT6
LGR6
POLR1C
PLAG1
AXIN2
TTC3
ZNF135
FAM129C
SPOCK2
CNN3
ZNF439
MTA3
C2orf40
GBP5
EPB41L4A-AS1
EFNA1
BHLHE40
APOBEC3G
ZNF256
LPP
C1orf162
NIPAL3
P2RX7
EXOSC5
SLC25A20
GAB3
PAQR8
ENOSF1
EIF3E
IGLL1
EOMES
TEX10
MAGED1
KLF10
UBASH3A
SPTBN1
MTSS1
HSF2
PTPN7
ARHGEF18
TRAP1
TSHZ2
EIF3H
SNTB2
ZNF550
BCL11A
CTNNA1
HLA-DOA
IL10RA
HSP90B1
SCD
POLR1E
SNRPN
SORT1
ADSL
LARS
SYPL1
PTGER2
SLC38A1
CIRH1A
GSPT2
APH1B
E2F5
SERINC5
EIF3L
CHMP7
MARCH1
DDX10
LAGE3
ITGB1
WDR75
CCDC109B
PFAS
FAM213A
TIGD7
PKIA
CD70
----------++++++
-----++++++
++++++
---?------++++++
---------------++++++
----------++++++
-----+
-----++++++
----------++++++
----------++++++
++-+++
++++++
++++++
--------------------++++++
++++++
-----+++?++
--------+-++++++
--------------------++++++
----------+++?++
-----++++++
++++++
-----++++++
++++++
++++++
++-+++
++++++
++++++
-----++++++
----------+
----------++++++
++++++
++++++
-------------------------+
++++++
----------++-+++
-------------------------------------------------------++++++
----------++++++
++++++
-----++++++
++++++
-----++++++
-----++++++
++++++
--------------------+
++-+++
----------++++++
----------++-+++
-----++-+++
----------+--+++
-----++-+++
--+-------++++++
-----++-+++
--------------------++++++
---------------++++++
--------+------++++++
--------------------+++?++
----------++-?++
----------------------------?-++++++
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
-9.714
-12.335
10.413
-12.306
10.786
13.818
-12.162
-12.542
11.482
-12.237
-12.054
-12.879
11.165
-11.822
-11.242
11.273
-7.863
-11.178
11.190
-12.078
-13.193
9.334
-10.785
-10.795
13.058
10.191
9.630
9.624
-9.558
-11.177
-12.790
-10.679
13.436
9.132
-11.930
10.872
-11.061
-9.548
11.125
-10.269
-11.383
-12.492
-11.392
9.991
-10.913
-9.895
10.388
-9.547
9.833
11.535
-10.139
10.224
10.159
8.437
9.282
10.322
11.331
-11.851
9.913
-10.015
-9.719
-11.263
-6.899
8.885
10.557
10.655
-8.601
-11.773
-11.093
-11.410
-8.588
8.352
-9.315
-12.080
9.860
-9.471
-10.741
-10.783
-10.461
-10.474
-8.756
-11.590
-11.546
-10.657
-8.902
-9.381
9.115
-10.271
-13.187
9.512
9.547
-11.172
9.421
11.010
-10.000
10.197
-9.408
11.621
8.630
-11.875
-9.890
-9.556
-8.157
9.242
-9.604
-9.253
9.250
-10.841
-11.574
7.898
-9.777
7.835
-9.188
-9.275
6.329
-10.904
8.321
-9.841
-9.285
9.504
-8.359
7.809
-9.347
-8.186
-10.564
-9.249
10.127
-9.306
-9.079
-9.875
9.062
-10.049
-10.139
-11.113
8.160
-9.667
-10.100
-10.134
-9.888
9.914
-9.769
-8.291
7.509
-10.364
-9.561
-8.318
-9.311
-9.438
-8.944
9.914
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2.64E-22
5.86E-35
2.15E-25
8.38E-35
4.01E-27
1.98E-43
4.97E-34
4.40E-36
1.63E-30
1.96E-34
1.86E-33
5.94E-38
6.06E-29
3.02E-32
2.53E-29
1.79E-29
3.75E-15
5.22E-29
4.55E-29
1.38E-33
9.63E-40
1.02E-20
4.07E-27
3.64E-27
5.69E-39
2.18E-24
5.97E-22
6.31E-22
1.20E-21
5.26E-29
1.86E-37
1.28E-26
3.73E-41
6.70E-20
8.21E-33
1.57E-27
1.94E-28
1.32E-21
9.49E-29
9.74E-25
5.09E-30
8.22E-36
4.56E-30
1.67E-23
9.98E-28
4.36E-23
2.81E-25
1.33E-21
8.11E-23
8.76E-31
3.70E-24
1.55E-24
3.02E-24
3.25E-17
1.66E-20
5.59E-25
9.26E-30
2.13E-32
3.64E-23
1.31E-23
2.50E-22
2.01E-29
5.25E-12
6.41E-19
4.71E-26
1.66E-26
7.93E-18
5.36E-32
1.35E-28
3.71E-30
8.85E-18
6.72E-17
1.22E-20
1.34E-33
6.19E-23
2.77E-21
6.51E-27
4.13E-27
1.30E-25
1.14E-25
2.02E-18
4.62E-31
7.78E-31
1.62E-26
5.46E-19
6.52E-21
7.88E-20
9.49E-25
1.04E-39
1.88E-21
1.34E-21
5.59E-29
4.46E-21
3.43E-28
1.52E-23
2.05E-24
5.05E-21
3.21E-31
6.13E-18
1.59E-32
4.62E-23
1.22E-21
3.42E-16
2.42E-20
7.67E-22
2.19E-20
2.25E-20
2.21E-27
5.60E-31
2.83E-15
1.41E-22
4.67E-15
4.01E-20
1.78E-20
2.47E-10
1.11E-27
8.70E-17
7.46E-23
1.62E-20
2.02E-21
6.34E-17
5.75E-15
9.01E-21
2.71E-16
4.40E-26
2.27E-20
4.21E-24
1.32E-20
1.10E-19
5.35E-23
1.29E-19
9.24E-24
3.69E-24
1.08E-28
3.35E-16
4.17E-22
5.51E-24
3.89E-24
4.69E-23
3.60E-23
1.53E-22
1.12E-16
5.98E-14
3.62E-25
1.16E-21
8.97E-17
1.26E-20
3.79E-21
3.74E-19
3.63E-23
------------+-++++++++
------?++++++++
+++-++++
--------------+-++++++
---------------------++++++++
------------+--+++++++
------------+-++++++++
--------------+++-++?+
----------+---++++++++
+++-++++
+++-++++
++++-+++
------------+---------------++++++++
++++++++
-------++++++++
--------------++++++++
--------------+
------------+-+++-++++
---+----------++++++++
-------++++++++
+++++-++
---+---++++++++
++++--++
+++++-++
+++-++++
++++++++
+++-++++
-----+-++++++++
-------------------------+--++++++++
++++--++
+++-++++
------------+----------------------++++++++
---+--------+-?
++++++++
-----------------+---------------??---+------+---------?-----------------?-?-++++++++
------------??++++-+++
+++-++++
-------+++?++++
++++++++
---+---?
++++++++
-------+++---++
+++-++++
----------------------------+
++++++++
--------------?+++-??+
---+--------+-++++++++
-------++++++++
------------+-++++-+++
-------++++++++
----------++--++++++++
-------++-+++++
----------------------------++++++++
-----------------+---++++--++
---------------------++++++++
-+--------------------------++++++-+
--------------++++-+++
-------------------+----+---+-------------++++++++
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
4829
8009
8009
8009
8009
8009
6325
8009
8009
6552
8009
8009
7423
8009
8009
6325
8009
8009
8009
7650
8009
4829
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
-12.26
-9.75
11.54
-9.58
11.06
8.16
-9.82
-9.32
10.31
-9.58
-9.68
-8.86
10.48
-9.85
-10.35
10.32
-13.56
-10.37
10.34
-9.45
-8.32
12.09
-10.54
-10.52
8.33
11.04
11.48
11.48
-11.52
-9.94
-8.38
-10.38
7.74
11.83
-9.11
10.14
-9.90
-11.34
9.82
-10.62
-9.52
-8.43
-9.45
10.69
-9.72
-10.66
10.21
-10.94
10.65
9.03
-10.28
10.20
10.23
11.84
11.01
10.00
9.04
-8.49
10.30
-10.14
-10.37
-8.90
-13.04
11.09
9.46
9.35
-11.31
-8.26
-8.89
-8.58
-11.16
11.36
-10.41
-7.22
9.84
-10.19
-8.96
-8.90
-9.20
-9.11
-10.79
-8.07
-7.94
-8.95
-10.60
-10.13
10.37
-9.25
-6.05
9.95
9.90
-8.34
9.98
8.44
-9.41
9.17
-9.90
7.72
10.57
-7.39
-9.28
-9.58
-10.91
9.87
-9.52
-9.84
9.95
-8.27
-7.55
11.04
-9.23
11.03
-9.74
-9.65
12.45
-8.09
10.55
-9.05
-9.58
9.37
-10.45
10.92
-9.44
-10.52
-8.21
-9.43
8.56
-9.33
-9.54
-8.78
9.52
-8.56
-8.46
-7.52
10.31
-8.88
-8.46
-8.42
-8.62
8.65
-8.71
-10.11
10.77
-8.09
-8.82
-9.97
-9.02
-8.90
-9.37
8.43
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.49E-34
1.83E-22
8.11E-31
9.39E-22
1.94E-28
3.39E-16
9.23E-23
1.14E-20
6.25E-25
9.78E-22
3.57E-22
8.03E-19
1.11E-25
6.81E-23
4.18E-25
5.70E-25
7.06E-42
3.57E-25
4.77E-25
3.26E-21
8.80E-17
1.23E-33
5.64E-26
7.25E-26
7.79E-17
2.45E-28
1.73E-30
1.70E-30
1.00E-30
2.70E-23
5.49E-17
2.98E-25
1.02E-14
2.69E-32
8.14E-20
3.77E-24
4.00E-23
8.25E-30
9.46E-23
2.43E-26
1.68E-21
3.51E-17
3.32E-21
1.18E-26
2.49E-22
1.56E-26
1.77E-24
7.63E-28
1.68E-26
1.79E-19
8.31E-25
2.03E-24
1.47E-24
2.35E-32
3.59E-28
1.56E-23
1.62E-19
2.14E-17
7.18E-25
3.66E-24
3.36E-25
5.80E-19
7.19E-39
1.38E-28
3.10E-21
8.44E-21
1.23E-29
1.52E-16
6.25E-19
9.53E-18
6.51E-29
7.00E-30
2.28E-25
5.18E-13
7.89E-23
2.13E-24
3.36E-19
5.72E-19
3.69E-20
8.23E-20
3.89E-27
6.98E-16
2.09E-15
3.56E-19
3.13E-26
4.23E-24
3.55E-25
2.18E-20
1.42E-09
2.65E-23
4.03E-23
7.27E-17
1.83E-23
3.23E-17
4.80E-21
4.60E-20
4.27E-23
1.14E-14
4.20E-26
1.51E-13
1.77E-20
9.34E-22
9.88E-28
5.59E-23
1.66E-21
7.91E-23
2.64E-23
1.34E-16
4.22E-14
2.46E-28
2.64E-20
2.82E-28
2.11E-22
4.96E-22
1.36E-35
5.85E-16
5.08E-26
1.45E-19
9.98E-22
7.56E-21
1.55E-25
9.62E-28
3.58E-21
6.81E-26
2.30E-16
4.11E-21
1.11E-17
1.08E-20
1.46E-21
1.71E-18
1.76E-21
1.10E-17
2.67E-17
5.61E-14
6.09E-25
6.74E-19
2.63E-17
3.69E-17
6.83E-18
5.15E-18
3.09E-18
5.20E-24
4.69E-27
5.84E-16
1.19E-18
2.08E-23
1.90E-19
5.72E-19
7.13E-21
3.37E-17
15266
15266
15266
13809
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13809
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12086
15266
15266
15266
15266
15266
13582
15266
15266
13809
15266
15266
14680
15266
15266
13582
15266
15266
15266
14907
15266
12086
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12620
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
14385
15266
15266
15266
15266
15266
14385
15266
-15.577
-15.567
15.54
-15.522
15.448
15.437
-15.424
-15.399
15.385
-15.376
-15.324
-15.297
15.286
-15.286
-15.248
15.247
-15.242
-15.215
15.203
-15.175
-15.122
15.093
-15.07
-15.06
15.04
15.023
14.952
14.949
-14.937
-14.908
-14.885
-14.883
14.867
14.866
-14.825
14.802
-14.8
-14.797
14.781
-14.772
-14.746
-14.718
-14.701
14.629
-14.564
-14.544
14.535
-14.505
14.496
14.49
-14.44
14.435
14.413
14.395
14.371
14.358
14.357
-14.317
14.294
-14.25
-14.213
-14.209
-14.202
14.159
14.13
14.121
-14.119
-14.096
-14.086
-14.081
-14.003
13.983
-13.961
-13.925
13.923
-13.913
-13.893
-13.879
-13.874
-13.873
-13.852
-13.837
-13.836
-13.83
-13.812
-13.797
13.792
-13.784
-13.77
13.761
13.755
-13.745
13.724
13.703
-13.699
13.675
-13.655
13.606
13.605
-13.538
-13.537
-13.531
-13.53
13.521
-13.521
-13.503
13.498
-13.464
-13.451
13.442
-13.428
13.39
-13.387
-13.384
13.383
-13.379
13.379
-13.339
-13.338
13.336
-13.328
13.291
-13.285
-13.265
-13.226
-13.207
13.184
-13.173
-13.168
-13.164
13.142
-13.131
-13.119
-13.107
13.097
-13.096
-13.093
-13.088
-13.059
13.055
-13.043
-13.036
13.036
-13.007
-12.978
-12.956
-12.953
-12.952
-12.948
12.943
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.04E-54
1.21E-54
1.87E-54
2.45E-54
7.76E-54
9.29E-54
1.13E-53
1.65E-53
2.06E-53
2.38E-53
5.30E-53
8.06E-53
9.49E-53
9.54E-53
1.70E-52
1.71E-52
1.86E-52
2.83E-52
3.38E-52
5.17E-52
1.15E-51
1.81E-51
2.55E-51
2.97E-51
4.01E-51
5.22E-51
1.51E-50
1.57E-50
1.90E-50
2.90E-50
4.12E-50
4.26E-50
5.36E-50
5.47E-50
1.01E-49
1.42E-49
1.47E-49
1.52E-49
1.93E-49
2.23E-49
3.27E-49
4.96E-49
6.35E-49
1.84E-48
4.74E-48
6.38E-48
7.26E-48
1.13E-47
1.28E-47
1.39E-47
2.91E-47
3.10E-47
4.26E-47
5.56E-47
7.83E-47
9.45E-47
9.60E-47
1.71E-46
2.38E-46
4.50E-46
7.62E-46
8.11E-46
8.92E-46
1.63E-45
2.47E-45
2.81E-45
2.91E-45
3.99E-45
4.64E-45
4.94E-45
1.49E-44
1.98E-44
2.70E-44
4.46E-44
4.62E-44
5.28E-44
6.99E-44
8.47E-44
9.09E-44
9.25E-44
1.25E-43
1.53E-43
1.54E-43
1.68E-43
2.15E-43
2.67E-43
2.83E-43
3.18E-43
3.85E-43
4.36E-43
4.74E-43
5.43E-43
7.29E-43
9.80E-43
1.03E-42
1.44E-42
1.87E-42
3.68E-42
3.76E-42
9.37E-42
9.48E-42
1.03E-41
1.05E-41
1.17E-41
1.18E-41
1.49E-41
1.62E-41
2.54E-41
3.03E-41
3.44E-41
4.12E-41
6.95E-41
7.22E-41
7.54E-41
7.62E-41
8.02E-41
8.04E-41
1.37E-40
1.38E-40
1.42E-40
1.58E-40
2.60E-40
2.82E-40
3.68E-40
6.18E-40
8.01E-40
1.09E-39
1.26E-39
1.35E-39
1.41E-39
1.90E-39
2.19E-39
2.57E-39
3.01E-39
3.44E-39
3.46E-39
3.62E-39
3.87E-39
5.61E-39
5.95E-39
6.98E-39
7.59E-39
7.61E-39
1.11E-38
1.64E-38
2.19E-38
2.27E-38
2.29E-38
2.42E-38
2.56E-38
+
+
+
?
?
?
?
?
+
?
+
?
?
?
?
?
+
+
?
+
?
?
+
+
+
?
?
+
?
+
?
+
+
+
?
?
+
?
?
?
+
?
?
?
?
?
+
?
?
+
+
?
?
?
+
?
+
?
?
+
?
+
?
+
+
?
?
+
+
+
?
+
+
+
+
?
?
?
?
?
+
?
+
?
?
?
+
?
+
?
+
?
?
?
?
?
+
?
+
+
?
+
?
?
?
?
+
?
+
+
?
+
?
+
+
?
394
394
394
0
0
0
0
0
394
394
394
394
0
394
0
0
0
394
0
394
0
394
394
0
394
0
0
394
394
394
394
0
0
394
394
0
394
0
394
394
394
0
0
394
0
0
0
394
394
0
0
0
394
0
0
394
0
394
394
0
394
394
394
0
0
0
394
394
394
394
394
0
394
0
0
394
0
394
394
394
0
394
394
394
0
394
0
394
394
394
0
394
394
394
394
0
394
0
0
0
0
394
0
394
394
0
0
0
394
394
394
0
394
394
0
394
394
0
0
0
0
0
394
394
394
0
394
394
394
394
0
394
394
0
0
0
0
394
0
394
394
0
394
394
0
394
394
394
394
0
0.010
0.017
0.001
ns
ns
ns
ns
ns
-0.013
0.002
-0.008
-0.001
ns
0.011
ns
ns
ns
-0.009
ns
-0.009
ns
0.003
0.000
ns
0.004
ns
ns
0.017
-0.003
0.013
0.001
ns
ns
0.005
-0.006
ns
0.000
ns
0.005
0.000
0.012
ns
ns
0.008
ns
ns
ns
0.008
0.000
ns
ns
ns
-0.003
ns
ns
0.002
ns
-0.008
-0.002
ns
0.000
0.000
0.001
ns
ns
ns
0.005
-0.005
-0.004
-0.004
-0.006
ns
0.001
ns
ns
0.018
ns
0.003
-0.002
-0.009
ns
0.001
-0.004
0.003
ns
-0.023
ns
0.006
0.005
0.015
ns
0.009
0.013
0.017
0.012
ns
-0.004
ns
ns
ns
ns
0.011
ns
-0.014
0.009
ns
ns
ns
0.007
-0.006
-0.001
ns
-0.003
0.004
ns
-0.003
0.010
ns
ns
ns
ns
ns
-0.007
-0.012
0.007
ns
-0.003
0.002
0.008
-0.009
ns
-0.007
0.007
ns
ns
ns
ns
0.002
ns
0.006
0.001
ns
-0.005
0.006
ns
0.004
-0.002
-0.002
0.000
ns
0.003
0.003
0.003
ns
ns
ns
ns
ns
0.003
0.003
0.003
0.004
ns
0.003
ns
ns
ns
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
ns
ns
0.003
0.004
0.003
0.003
ns
ns
0.003
0.003
ns
0.004
ns
0.004
0.003
0.003
ns
ns
0.003
ns
ns
ns
0.003
0.003
ns
ns
ns
0.003
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.004
ns
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.004
0.003
0.003
ns
0.004
0.003
0.003
0.003
ns
0.003
ns
ns
ns
ns
0.004
ns
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
0.004
0.003
ns
0.003
0.003
ns
ns
ns
ns
ns
0.003
0.004
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
0.004
ns
3.38E-04
3.18E-08
7.84E-01
ns
ns
ns
ns
ns
1.42E-05
4.76E-01
1.76E-02
7.59E-01
ns
1.25E-03
ns
ns
ns
4.43E-03
ns
6.20E-03
ns
3.52E-01
8.89E-01
ns
2.55E-01
ns
ns
1.83E-07
3.50E-01
7.86E-06
7.17E-01
ns
ns
9.78E-02
4.95E-02
ns
9.17E-01
ns
1.75E-01
9.60E-01
7.30E-05
ns
ns
5.43E-03
ns
ns
ns
1.77E-02
9.01E-01
ns
ns
ns
3.76E-01
ns
ns
5.89E-01
ns
1.49E-02
5.33E-01
ns
9.02E-01
9.18E-01
8.76E-01
ns
ns
ns
1.38E-01
1.07E-01
2.34E-01
1.94E-01
8.15E-02
ns
7.00E-01
ns
ns
1.02E-08
ns
2.78E-01
4.60E-01
8.81E-03
ns
6.96E-01
2.21E-01
4.27E-01
ns
1.61E-10
ns
8.86E-02
1.51E-01
1.19E-06
ns
1.01E-02
6.64E-06
1.86E-10
1.50E-04
ns
1.90E-01
ns
ns
ns
ns
1.92E-03
ns
1.23E-05
2.08E-03
ns
ns
ns
6.91E-03
4.61E-02
7.86E-01
ns
3.38E-01
2.28E-01
ns
2.89E-01
1.23E-04
ns
ns
ns
ns
ns
3.64E-02
6.04E-04
3.68E-02
ns
3.52E-01
5.81E-01
1.69E-02
7.05E-03
ns
3.07E-02
3.69E-02
ns
ns
ns
ns
5.14E-01
ns
5.78E-02
7.65E-01
ns
1.16E-01
7.38E-02
ns
1.91E-01
5.88E-01
5.91E-01
9.34E-01
ns
+
+
+
?
?
?
?
?
+
+
+
?
+
?
?
?
?
?
+
?
+
?
?
+
+
+
?
?
+
?
?
+
+
?
+
?
?
?
+
+
?
?
?
?
?
+
?
+
+
?
+
+
?
+
?
+
+
+
?
+
?
?
+
?
+
?
+
+
?
?
?
+
+
?
?
+
+
+
?
+
?
?
?
+
?
?
+
?
?
?
?
+
+
+
?
?
?
?
+
+
+
?
+
?
+
?
?
?
?
+
?
+
?
+
+
+
+
+
+
?
394
394
394
0
0
0
0
0
394
394
394
394
0
394
0
0
0
394
0
394
0
394
394
0
394
0
0
394
394
394
394
0
0
394
394
0
394
0
394
394
394
394
0
394
0
0
0
394
394
0
0
0
394
0
0
394
0
394
394
0
394
394
394
0
394
0
394
394
394
394
394
0
394
0
0
394
0
394
394
394
0
394
394
394
0
0
0
394
394
394
0
0
394
394
394
0
394
394
0
0
0
394
0
0
394
0
0
0
394
394
394
0
394
394
394
394
394
0
394
0
0
0
394
394
394
0
394
394
394
394
0
394
394
0
0
0
0
394
0
394
394
0
394
394
394
394
394
394
394
0
0.016
0.007
0.000
ns
ns
ns
ns
ns
0.003
0.009
-0.009
0.018
ns
0.005
ns
ns
ns
-0.003
ns
-0.011
ns
0.003
-0.006
ns
0.014
ns
ns
0.008
-0.012
0.013
0.014
ns
ns
0.008
-0.016
ns
-0.001
ns
0.007
-0.006
0.003
-0.012
ns
0.011
ns
ns
ns
0.011
0.013
ns
ns
ns
-0.002
ns
ns
0.013
ns
0.004
0.012
ns
-0.002
0.002
0.010
ns
0.010
ns
0.007
-0.011
0.006
-0.007
0.008
ns
0.000
ns
ns
0.011
ns
-0.001
-0.010
0.006
ns
0.006
0.008
0.000
ns
ns
ns
-0.014
0.010
0.006
ns
ns
0.007
0.011
0.006
ns
-0.006
0.005
ns
ns
ns
0.012
ns
ns
0.002
ns
ns
ns
-0.001
-0.005
-0.001
ns
0.008
-0.005
0.006
-0.005
0.004
ns
-0.007
ns
ns
ns
0.003
0.002
0.011
ns
0.017
-0.003
-0.003
-0.001
ns
-0.004
0.012
ns
ns
ns
ns
0.003
ns
0.001
-0.009
ns
0.003
0.016
-0.010
0.006
0.001
0.004
0.002
ns
0.003
0.003
0.003
ns
ns
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.004
ns
ns
ns
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
ns
ns
0.003
0.003
0.002
0.003
ns
ns
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
ns
0.003
0.003
ns
ns
ns
0.004
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.004
0.003
0.003
ns
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.004
0.003
0.003
ns
ns
ns
0.003
0.003
0.004
ns
ns
0.003
0.002
0.003
ns
0.003
0.003
ns
ns
ns
0.003
ns
ns
0.003
ns
ns
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
0.004
ns
ns
ns
0.003
0.004
0.003
ns
0.003
0.003
0.003
0.004
ns
0.003
0.003
ns
ns
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.004
0.003
0.004
0.003
0.003
ns
5.98E-08
3.57E-02
9.21E-01
ns
ns
ns
ns
ns
3.43E-01
6.22E-03
1.36E-02
5.30E-10
ns
1.39E-01
ns
ns
ns
2.92E-01
ns
6.78E-04
ns
3.17E-01
9.71E-02
ns
4.26E-06
ns
ns
1.79E-02
4.26E-04
2.56E-07
1.55E-05
ns
ns
9.10E-03
4.15E-06
ns
7.49E-01
ns
3.18E-02
6.80E-02
3.99E-01
7.50E-04
ns
3.99E-04
ns
ns
ns
1.26E-03
6.19E-05
ns
ns
ns
6.16E-01
ns
ns
6.66E-05
ns
2.92E-01
3.40E-04
ns
4.90E-01
5.96E-01
3.39E-03
ns
1.75E-03
ns
2.92E-02
3.22E-04
7.11E-02
1.63E-02
1.45E-02
ns
9.08E-01
ns
ns
1.40E-03
ns
7.03E-01
1.92E-03
4.81E-02
ns
9.27E-02
1.65E-02
8.98E-01
ns
ns
ns
1.46E-05
1.66E-03
1.14E-01
ns
ns
1.69E-02
5.18E-06
7.68E-02
ns
6.29E-02
1.30E-01
ns
ns
ns
3.60E-04
ns
ns
6.12E-01
ns
ns
ns
7.11E-01
1.46E-01
8.24E-01
ns
1.10E-02
1.03E-01
3.65E-02
1.08E-01
1.88E-01
ns
4.57E-02
ns
ns
ns
3.52E-01
5.19E-01
6.37E-04
ns
3.72E-08
3.35E-01
3.81E-01
8.16E-01
ns
3.08E-01
3.05E-04
ns
ns
ns
ns
3.98E-01
ns
6.99E-01
9.07E-03
ns
3.36E-01
1.14E-06
7.40E-03
7.15E-02
7.71E-01
2.55E-01
6.12E-01
ns
-+
?-+
-++
++
-+++
++-++
--+--++
+++
++-+
?+
?+
+++
?+
---++
++
+++
+?+?-?++
++
-+
-+
-+
-?
++
?+
-++
++
++
?++
++
-++
-?
++-?
++
++
?+
-?---+
++
-?
?+
??--??+
+-+
-?-+
?+
-?
-?
?+
-++
++
-?
?+
+++
?
+---+
?+
?-?
++
+-++
-++
--++
?++
--++
-++
+--?++
-+-++
---?
+?-?-++
--?
++
+----+
+++
515
213
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
213
213
515
515
213
515
515
515
515
515
515
515
515
213
515
213
515
213
515
515
515
515
515
302
515
213
515
515
515
515
213
515
515
515
515
302
515
515
302
515
515
213
515
213
515
515
515
515
515
0
213
213
213
515
515
213
213
515
515
515
213
515
213
302
515
0
213
515
515
515
302
213
515
515
0
515
515
515
515
213
213
302
515
515
515
515
515
515
515
515
515
213
515
515
515
515
515
515
515
515
515
213
515
515
515
515
515
515
515
302
515
213
515
213
515
515
515
302
515
515
515
515
515
515
515
515
0.420
-2.160
0.796
-2.863
1.611
2.576
-1.735
0.765
1.996
0.939
-0.304
-3.748
4.321
-2.008
-3.165
-0.298
-1.725
-4.224
3.520
-2.019
0.682
-0.984
-1.569
0.443
0.986
2.081
1.328
2.492
0.744
-1.821
-0.793
-0.598
2.545
4.328
-0.264
4.182
-0.729
-5.412
1.390
-1.126
-1.476
-0.654
1.176
3.825
0.085
-0.930
-0.042
-2.068
4.034
1.007
-2.146
6.579
8.579
4.811
-1.826
1.940
6.178
-2.111
2.395
-0.721
2.999
-0.290
-2.825
2.429
1.372
0.919
-2.322
-1.660
-1.189
-1.121
-0.180
4.966
-3.052
ns
2.734
-1.408
-0.919
-1.785
-1.223
-1.193
1.034
0.720
-1.609
-3.033
-5.745
-0.080
2.432
-0.543
-5.125
ns
4.878
-3.294
0.747
3.478
-0.532
0.645
0.208
2.620
ns
-0.131
-2.619
-1.794
-0.527
4.915
-2.695
-1.359
4.005
-0.938
-3.156
1.076
-2.796
1.816
-1.535
-1.233
3.533
-0.872
2.546
-1.656
-3.909
3.924
-1.936
6.455
0.153
-2.547
-1.173
-3.223
0.007
-2.133
-0.034
-0.962
6.500
-0.884
-1.893
-4.559
0.310
-3.149
-2.799
-1.279
-5.051
2.420
-1.387
-0.348
3.366
-0.311
-1.726
-2.694
-2.208
-0.677
-0.712
5.014
6.75E-01
3.08E-02
4.26E-01
4.19E-03
1.07E-01
1.00E-02
8.27E-02
4.44E-01
4.59E-02
3.48E-01
7.61E-01
1.79E-04
1.55E-05
4.47E-02
1.55E-03
7.66E-01
8.45E-02
2.40E-05
4.31E-04
4.35E-02
4.95E-01
3.25E-01
1.17E-01
6.57E-01
3.24E-01
3.74E-02
1.84E-01
1.27E-02
4.57E-01
6.86E-02
4.28E-01
5.50E-01
1.09E-02
1.50E-05
7.92E-01
2.89E-05
4.66E-01
6.24E-08
1.65E-01
2.60E-01
1.40E-01
5.13E-01
2.40E-01
1.31E-04
9.32E-01
3.52E-01
9.66E-01
3.86E-02
5.48E-05
3.14E-01
3.19E-02
4.73E-11
9.55E-18
1.50E-06
6.79E-02
5.24E-02
6.50E-10
3.48E-02
1.66E-02
4.71E-01
2.71E-03
7.72E-01
4.73E-03
1.52E-02
1.70E-01
3.58E-01
2.02E-02
9.69E-02
2.35E-01
2.62E-01
8.57E-01
6.85E-07
2.27E-03
ns
6.25E-03
1.59E-01
3.58E-01
7.42E-02
2.21E-01
2.33E-01
3.01E-01
4.71E-01
1.08E-01
2.42E-03
9.20E-09
9.37E-01
1.50E-02
5.87E-01
2.98E-07
ns
1.07E-06
9.86E-04
4.55E-01
5.06E-04
5.95E-01
5.19E-01
8.36E-01
8.78E-03
ns
8.96E-01
8.82E-03
7.29E-02
5.98E-01
8.87E-07
7.04E-03
1.74E-01
6.19E-05
3.48E-01
1.60E-03
2.82E-01
5.17E-03
6.94E-02
1.25E-01
2.17E-01
4.11E-04
3.83E-01
1.09E-02
9.78E-02
9.26E-05
8.71E-05
5.29E-02
1.09E-10
8.79E-01
1.09E-02
2.41E-01
1.27E-03
9.94E-01
3.29E-02
9.73E-01
3.36E-01
8.03E-11
3.77E-01
5.83E-02
5.15E-06
7.56E-01
1.64E-03
5.13E-03
2.01E-01
4.40E-07
1.55E-02
1.65E-01
7.28E-01
7.63E-04
7.56E-01
8.44E-02
7.06E-03
2.72E-02
4.99E-01
4.77E-01
5.34E-07
?
+
+
+
+
+
+
+
+
+
?
?
+
+
?
+
+
+
?
+
?
?
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
?
+
?
?
?
?
?
?
?
?
?
?
+
+
?
+
?
?
?
+
+
+
+
?
+
+
+
?
+
+
?
?
+
+
+
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
0
299
299
0
299
299
299
299
299
299
299
299
0
299
0
299
0
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
0
0
0
0
299
299
0
0
299
299
299
0
299
0
299
299
0
0
299
299
299
299
0
299
299
0
299
299
299
299
0
0
299
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
0
299
0
299
299
299
299
299
299
299
299
299
299
299
299
-0.039
ns
0.002
-0.032
0.007
0.008
-0.025
-0.010
0.020
-0.005
-0.015
-0.010
0.035
-0.034
-0.022
0.008
-0.013
-0.012
0.045
-0.020
0.008
0.003
-0.018
-0.029
ns
ns
0.027
0.007
ns
-0.038
-0.011
-0.025
0.017
0.041
-0.006
0.006
-0.009
ns
0.024
ns
-0.021
ns
-0.014
0.049
-0.008
-0.044
0.003
-0.024
0.014
ns
-0.003
0.023
0.016
0.028
0.009
0.017
0.039
-0.002
0.067
-0.035
0.002
-0.022
-0.008
0.050
0.004
0.009
-0.021
ns
-0.035
-0.025
-0.007
0.017
-0.020
ns
ns
ns
ns
-0.011
-0.018
ns
ns
-0.006
-0.009
-0.024
ns
-0.006
ns
-0.021
-0.024
ns
ns
-0.034
0.007
0.018
-0.013
ns
-0.003
0.009
ns
-0.015
-0.026
-0.024
-0.024
ns
ns
-0.023
0.008
-0.018
-0.006
0.006
-0.026
0.023
-0.010
-0.014
0.006
ns
0.016
-0.019
0.000
0.014
-0.029
0.023
-0.002
-0.016
-0.023
ns
0.007
-0.019
-0.005
-0.009
0.024
-0.012
-0.007
-0.011
0.000
ns
-0.032
ns
-0.037
0.005
-0.009
-0.015
0.048
-0.011
-0.023
-0.018
-0.007
-0.004
-0.018
0.007
0.007
ns
0.002
0.006
0.003
0.003
0.005
0.006
0.013
0.005
0.007
0.006
0.006
0.006
0.005
0.006
0.007
0.004
0.014
0.005
0.006
0.004
0.005
0.007
ns
ns
0.006
0.003
ns
0.006
0.007
0.008
0.006
0.007
0.005
0.004
0.006
ns
0.007
ns
0.004
ns
0.006
0.010
0.005
0.004
0.003
0.005
0.008
ns
0.002
0.005
0.005
0.007
0.004
0.005
0.010
0.003
0.011
0.008
0.004
0.006
0.005
0.013
0.002
0.003
0.007
ns
0.007
0.005
0.004
0.006
0.006
ns
ns
ns
ns
0.007
0.005
ns
ns
0.005
0.002
0.004
ns
0.002
ns
0.005
0.003
ns
ns
0.006
0.006
0.006
0.005
ns
0.002
0.004
ns
0.004
0.006
0.004
0.012
ns
ns
0.005
0.003
0.005
0.013
0.003
0.007
0.006
0.005
0.005
0.005
ns
0.006
0.004
0.004
0.005
0.004
0.006
0.005
0.005
0.004
ns
0.003
0.004
0.005
0.005
0.009
0.010
0.005
0.004
0.004
ns
0.006
ns
0.006
0.003
0.004
0.005
0.012
0.005
0.007
0.004
0.003
0.002
0.006
0.003
4.92E-08
ns
4.16E-01
1.62E-07
8.25E-03
1.05E-02
5.37E-07
9.75E-02
1.18E-01
2.79E-01
3.77E-02
1.04E-01
6.29E-08
1.06E-07
2.06E-06
1.75E-01
7.11E-02
1.03E-03
1.73E-03
2.32E-04
1.58E-01
4.40E-01
7.80E-04
1.24E-05
ns
ns
3.07E-06
2.42E-02
ns
1.09E-09
1.41E-01
2.22E-03
8.62E-03
2.96E-09
2.43E-01
1.05E-01
1.51E-01
ns
3.84E-04
ns
2.24E-06
ns
1.11E-02
5.94E-07
1.09E-01
1.15E-19
2.75E-01
2.03E-05
7.62E-02
ns
2.23E-01
3.77E-06
2.61E-03
6.55E-05
1.26E-02
2.99E-04
1.67E-04
4.58E-01
3.55E-09
1.25E-05
6.28E-01
1.49E-04
9.49E-02
2.42E-04
1.51E-01
7.41E-04
6.29E-03
ns
2.31E-07
9.63E-06
1.13E-01
8.05E-03
5.61E-04
ns
ns
ns
ns
1.17E-01
1.48E-04
ns
ns
2.00E-01
5.44E-06
1.27E-09
ns
1.36E-03
ns
5.12E-05
5.71E-12
ns
ns
1.11E-08
2.42E-01
3.44E-03
5.66E-03
ns
8.66E-02
3.55E-02
ns
6.72E-04
7.49E-05
8.04E-09
4.66E-02
ns
ns
1.60E-05
2.20E-02
1.29E-03
6.66E-01
3.19E-02
1.37E-04
3.63E-04
4.58E-02
3.99E-03
2.22E-01
ns
8.90E-03
1.14E-05
9.49E-01
3.06E-03
1.32E-11
4.55E-05
6.76E-01
1.25E-03
2.03E-07
ns
1.21E-02
2.08E-06
3.60E-01
7.42E-02
9.40E-03
2.56E-01
1.64E-01
2.15E-03
9.18E-01
ns
3.06E-08
ns
1.84E-08
6.62E-02
1.90E-02
4.50E-03
6.61E-05
2.88E-02
5.31E-04
8.80E-06
1.08E-02
1.01E-01
4.36E-03
2.95E-02
++--?
++
+?
-?
--+
-+
-+
-+
++
-+
-?
-+
++++
---+
-+
++
+?
+--+
++
--+
-++
-+
+----+
++-+
+++
-+++
?-+
-+
+-+
-?
-+
--++
+?
+?--?--+
+?
+--?
-++-?
++
--?
+-+
+?
+-+--+
+?
-+
?++
?+
-+-+
+?
?+
-+
--+
?+
++
-+
-+
+++
-?+
-+
+-+
++
-+
++
-+
-+--+
++
-+
-+
-+
-+
-+
-------+
++
--?-+-?
--+
+-?-+
--++?
-+
-++
567
567
567
213
567
213
213
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
354
567
567
567
567
213
567
567
567
567
213
567
354
567
567
354
567
567
213
567
567
213
567
567
567
567
0
567
567
213
567
567
213
567
567
567
567
567
213
567
354
567
354
567
567
567
213
354
567
567
567
354
567
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
354
567
567
213
567
567
567
567
354
567
567
567
567
213
567
567
567
0.544
-0.130
-1.882
-0.406
1.766
1.840
-1.119
-0.743
2.502
-0.387
-0.007
0.891
2.178
0.379
-0.472
-0.090
-0.563
0.021
2.592
-5.534
-0.783
0.997
-0.246
3.270
2.512
0.459
-0.853
1.496
1.362
-1.836
-0.925
-0.471
3.438
0.742
0.749
-2.669
-5.575
-1.615
0.844
-0.291
-1.068
-0.267
-0.955
3.189
-2.013
0.228
3.393
-0.040
3.395
-1.265
-0.637
1.547
-0.085
0.917
-1.742
-1.331
3.401
0.616
0.269
-2.078
-1.656
-3.272
-1.730
-1.255
3.327
1.981
-0.908
-3.934
-2.228
-1.823
0.263
1.027
-4.257
ns
1.682
-3.223
-0.068
0.840
-0.061
2.802
0.232
-1.100
0.627
-1.264
-0.788
1.646
2.205
-1.457
2.352
0.727
-1.098
-0.432
3.817
0.207
2.091
-0.052
-3.220
1.568
2.741
1.498
-0.097
-1.684
-1.699
1.083
-3.318
0.902
0.015
-0.238
-1.233
0.415
-0.559
1.574
1.622
-2.274
-0.248
-3.533
4.186
0.618
0.187
0.102
0.701
3.162
0.036
-3.070
-3.160
-2.818
-1.878
-2.940
-1.722
-0.591
3.699
-2.134
-2.757
-0.451
-1.840
-0.847
-1.685
-0.796
0.456
-1.085
-2.565
-0.842
-0.643
-1.546
-1.525
-0.103
0.403
-0.097
-1.800
1.494
5.86E-01
8.97E-01
5.99E-02
6.85E-01
7.74E-02
6.57E-02
2.63E-01
4.57E-01
1.23E-02
6.99E-01
9.95E-01
3.73E-01
2.94E-02
7.05E-01
6.37E-01
9.28E-01
5.73E-01
9.83E-01
9.55E-03
3.13E-08
4.34E-01
3.19E-01
8.06E-01
1.08E-03
1.20E-02
6.47E-01
3.94E-01
1.35E-01
1.73E-01
6.64E-02
3.55E-01
6.38E-01
5.87E-04
4.58E-01
4.54E-01
7.60E-03
2.47E-08
1.06E-01
3.99E-01
7.71E-01
2.86E-01
7.90E-01
3.40E-01
1.43E-03
4.42E-02
8.20E-01
6.91E-04
9.68E-01
6.86E-04
2.06E-01
5.24E-01
1.22E-01
9.32E-01
3.59E-01
8.15E-02
1.83E-01
6.71E-04
5.38E-01
7.88E-01
3.77E-02
9.77E-02
1.07E-03
8.37E-02
2.10E-01
8.79E-04
4.76E-02
3.64E-01
8.36E-05
2.59E-02
6.83E-02
7.93E-01
3.04E-01
2.08E-05
ns
9.26E-02
1.27E-03
9.46E-01
4.01E-01
9.51E-01
5.08E-03
8.17E-01
2.72E-01
5.30E-01
2.06E-01
4.31E-01
9.98E-02
2.75E-02
1.45E-01
1.87E-02
4.67E-01
2.72E-01
6.65E-01
1.35E-04
8.36E-01
3.65E-02
9.58E-01
1.28E-03
1.17E-01
6.12E-03
1.34E-01
9.23E-01
9.22E-02
8.93E-02
2.79E-01
9.08E-04
3.67E-01
9.88E-01
8.12E-01
2.18E-01
6.79E-01
5.76E-01
1.15E-01
1.05E-01
2.29E-02
8.04E-01
4.11E-04
2.84E-05
5.37E-01
8.51E-01
9.19E-01
4.84E-01
1.57E-03
9.72E-01
2.14E-03
1.58E-03
4.83E-03
6.05E-02
3.28E-03
8.50E-02
5.55E-01
2.16E-04
3.29E-02
5.83E-03
6.52E-01
6.58E-02
3.97E-01
9.19E-02
4.26E-01
6.48E-01
2.78E-01
1.03E-02
4.00E-01
5.20E-01
1.22E-01
1.27E-01
9.18E-01
6.87E-01
9.23E-01
7.19E-02
1.35E-01
?
+
+
?
?
+
+
+
+
+
?
+
+
+
+
+
+
+
+
+
?
?
?
+
?
+
+
+
?
?
+
?
+
+
?
+
+
?
+
?
?
+
+
+
+
?
?
?
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
+
+
+
?
+
+
+
+
+
+
-
869
869
0
869
869
0
0
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
0
0
869
0
869
869
869
869
869
869
869
869
869
0
0
869
0
869
869
0
869
869
869
869
869
869
869
0
869
0
0
869
869
869
869
869
869
869
869
869
869
869
869
0
869
0
869
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
0.000
-0.001
ns
0.000
0.012
ns
ns
-0.005
-0.003
0.002
0.003
-0.001
-0.004
0.003
0.001
-0.007
-0.001
0.001
ns
0.002
-0.003
0.000
0.007
0.004
-0.001
0.003
-0.001
-0.009
-0.002
-0.001
0.001
-0.001
-0.002
-0.002
0.000
-0.002
-0.001
0.003
0.001
-0.005
0.002
-0.003
ns
0.000
ns
ns
0.002
ns
-0.001
-0.002
-0.007
0.004
0.001
0.000
-0.004
0.001
-0.002
ns
ns
0.000
ns
0.001
0.004
ns
0.001
0.000
0.000
0.000
-0.006
0.000
-0.001
ns
0.002
ns
ns
0.001
0.001
0.001
-0.002
-0.003
-0.004
-0.001
-0.012
-0.004
-0.001
0.000
-0.001
ns
-0.002
ns
-0.001
-0.001
-0.002
-0.005
ns
0.000
0.001
0.000
-0.002
-0.001
-0.005
-0.002
-0.002
ns
0.001
0.002
0.002
-0.003
-0.004
-0.003
0.001
0.001
-0.001
0.002
0.002
-0.002
0.002
-0.003
0.000
-0.001
-0.003
-0.002
0.004
-0.005
0.000
-0.001
-0.004
0.004
-0.003
0.003
ns
0.000
0.005
0.001
0.000
0.000
-0.004
-0.001
0.001
ns
0.001
0.000
-0.001
0.001
0.005
0.003
-0.004
-0.003
0.001
-0.001
0.000
0.001
ns
0.001
0.003
ns
ns
0.003
0.003
0.001
0.001
0.001
0.002
0.003
0.001
0.003
0.001
0.001
ns
0.001
0.004
0.001
0.001
0.001
0.000
0.003
0.002
0.003
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.003
0.002
0.001
0.001
ns
0.001
ns
ns
0.002
ns
0.001
0.002
0.002
0.001
0.001
0.003
0.002
0.001
0.001
ns
ns
0.001
ns
0.001
0.002
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
ns
ns
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.003
ns
0.001
ns
0.001
0.001
0.001
0.003
ns
0.002
0.001
0.001
0.001
0.001
0.002
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.003
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.002
0.001
0.002
0.001
0.001
0.001
2.94E-01
5.06E-01
ns
7.21E-01
2.75E-05
ns
ns
1.10E-01
3.56E-01
1.02E-01
3.15E-02
6.98E-01
6.18E-02
2.25E-01
5.46E-01
5.95E-03
1.33E-01
3.99E-02
ns
2.08E-04
3.73E-01
7.94E-01
3.84E-08
2.07E-06
1.76E-03
3.53E-01
6.39E-01
6.76E-03
1.71E-02
5.14E-01
6.00E-01
4.57E-01
4.17E-02
1.46E-01
9.57E-01
1.34E-01
2.23E-01
6.74E-02
7.62E-01
1.80E-03
3.97E-02
5.23E-03
ns
5.08E-01
ns
ns
3.90E-01
ns
4.13E-01
3.37E-01
1.46E-04
4.30E-03
6.30E-02
9.43E-01
1.14E-01
1.81E-01
1.93E-01
ns
ns
9.21E-01
ns
1.38E-01
3.32E-02
ns
4.79E-01
7.91E-01
7.79E-01
9.23E-01
6.77E-06
7.19E-01
2.74E-01
ns
1.88E-01
ns
ns
5.70E-01
6.45E-01
1.37E-01
4.38E-03
9.22E-04
9.76E-05
3.59E-01
2.49E-04
3.09E-03
6.16E-01
9.78E-01
5.59E-01
ns
4.15E-03
ns
5.77E-01
3.27E-01
1.92E-01
4.10E-02
ns
9.24E-01
2.35E-01
7.59E-01
4.56E-02
4.23E-01
8.89E-04
7.45E-02
2.58E-02
ns
4.71E-01
1.37E-01
1.42E-01
1.20E-04
1.66E-04
8.25E-02
5.34E-01
2.39E-01
8.66E-02
2.27E-02
6.33E-02
1.19E-03
1.88E-02
4.85E-03
8.50E-01
3.42E-01
7.01E-02
2.78E-02
1.29E-03
6.67E-03
9.54E-01
2.11E-01
1.84E-01
2.96E-05
8.50E-03
2.33E-02
ns
7.65E-01
2.38E-06
7.60E-02
6.95E-01
9.23E-01
8.94E-03
1.85E-01
1.29E-01
ns
2.31E-01
8.25E-01
3.20E-01
2.40E-01
4.85E-03
2.80E-04
1.21E-02
6.75E-05
1.70E-01
2.94E-01
?
?
+
?
?
?
?
?
?
+
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
+
?
+
?
?
+
?
+
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
+
?
+
+
?
+
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
?
0
0
1244
0
0
0
0
0
1244
0
1244
1244
1244
0
0
0
0
0
1244
0
1244
0
1244
1244
0
0
0
0
0
0
1244
0
0
0
1244
0
0
1244
0
0
0
0
0
1244
0
0
0
1244
0
0
1244
1244
0
1244
0
0
1244
0
1244
0
1244
1244
1244
1244
0
0
0
0
0
0
0
0
0
1244
0
1244
0
0
0
0
1244
1244
0
0
0
1244
1244
1244
0
1244
1244
1244
0
1244
0
0
0
0
0
0
0
0
0
1244
0
0
0
0
0
0
1244
0
1244
1244
0
0
0
1244
0
0
0
1244
1244
0
1244
0
0
1244
0
0
1244
0
1244
0
0
0
1244
0
0
1244
1244
0
0
1244
1244
1244
0
1244
1244
0
ns
ns
0.001
ns
ns
ns
ns
ns
0.000
ns
-0.001
-0.002
0.009
ns
ns
ns
ns
ns
0.007
ns
-0.001
ns
-0.002
-0.002
ns
ns
ns
ns
ns
ns
-0.002
ns
ns
ns
-0.003
ns
ns
-0.006
ns
ns
ns
ns
ns
0.001
ns
ns
ns
-0.002
ns
ns
-0.005
0.002
ns
0.001
ns
ns
0.009
ns
0.005
ns
-0.002
-0.002
-0.007
0.003
ns
ns
ns
ns
ns
ns
ns
ns
ns
-0.002
ns
-0.001
ns
ns
ns
ns
-0.001
-0.002
ns
ns
ns
-0.001
0.006
-0.003
ns
0.005
0.003
-0.002
ns
0.001
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.009
ns
ns
ns
ns
ns
ns
-0.003
ns
-0.001
-0.002
ns
ns
ns
-0.002
ns
ns
ns
0.003
-0.002
ns
-0.002
ns
ns
-0.002
ns
ns
0.003
ns
-0.002
ns
ns
ns
-0.001
ns
ns
-0.001
-0.001
ns
ns
-0.002
-0.002
-0.002
ns
-0.002
-0.002
ns
ns
ns
0.000
ns
ns
ns
ns
ns
0.001
ns
0.000
0.000
0.001
ns
ns
ns
ns
ns
0.001
ns
0.001
ns
0.000
0.001
ns
ns
ns
ns
ns
ns
0.000
ns
ns
ns
0.001
ns
ns
0.001
ns
ns
ns
ns
ns
0.000
ns
ns
ns
0.000
ns
ns
0.001
0.000
ns
0.000
ns
ns
0.001
ns
0.001
ns
0.001
0.000
0.001
0.001
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.000
ns
0.000
ns
ns
ns
ns
0.000
0.001
ns
ns
ns
0.000
0.001
0.000
ns
0.001
0.000
0.000
ns
0.001
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.001
ns
ns
ns
ns
ns
ns
0.000
ns
0.000
0.000
ns
ns
ns
0.000
ns
ns
ns
0.000
0.001
ns
0.000
ns
ns
0.000
ns
ns
0.000
ns
0.000
ns
ns
ns
0.000
ns
ns
0.000
0.000
ns
ns
0.000
0.001
0.000
ns
0.000
0.000
ns
ns
ns
3.26E-03
ns
ns
ns
ns
ns
8.07E-01
ns
7.59E-02
8.26E-07
3.94E-36
ns
ns
ns
ns
ns
1.02E-08
ns
1.88E-01
ns
9.47E-12
1.34E-03
ns
ns
ns
ns
ns
ns
6.80E-08
ns
ns
ns
3.10E-05
ns
ns
1.38E-20
ns
ns
ns
ns
ns
4.11E-10
ns
ns
ns
2.01E-07
ns
ns
1.97E-07
1.02E-06
ns
6.02E-03
ns
ns
2.71E-21
ns
5.24E-15
ns
4.72E-05
4.85E-11
4.83E-13
1.37E-03
ns
ns
ns
ns
ns
ns
ns
ns
ns
4.92E-08
ns
1.21E-05
ns
ns
ns
ns
1.55E-04
4.84E-02
ns
ns
ns
2.78E-14
5.94E-17
2.68E-09
ns
3.45E-08
2.23E-10
3.84E-13
ns
4.05E-01
ns
ns
ns
ns
ns
ns
ns
ns
ns
1.62E-26
ns
ns
ns
ns
ns
ns
7.80E-13
ns
2.01E-03
2.67E-09
ns
ns
ns
6.65E-16
ns
ns
ns
7.42E-13
5.13E-04
ns
1.47E-08
ns
ns
1.42E-13
ns
ns
1.03E-15
ns
1.84E-10
ns
ns
ns
7.00E-06
ns
ns
1.39E-01
6.44E-06
ns
ns
2.26E-07
1.53E-04
1.15E-13
ns
1.41E-09
2.89E-06
ns
--++
-++?
-+
-+
+---+
++
--+
++
-+
-++
---+
-+
-+
++
++
++
++
-?
--+
-++
++
-++
-+
-++
----+
+?
+-?
++
-?
++
??
-++?
+-+
++
++
-+
++
-----+
++
+?
-?
--+
-+
-?
++
++
-?
++
---+
-+
-?
--+
-?
--?
-?
++
-?
-?
+?
++
+?
-+
+-?
-+
-+++
++
--+
-?
++
--+
+--++
-++
---?
-+
++
--+-++
---+
-+---+
-+
-+
-+
++
++
--?
++
-+-++
-+
--+
+--?
-+
+?
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
134
362
134
362
134
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
134
134
362
362
362
134
362
362
134
362
362
362
362
362
134
362
362
134
362
134
134
362
134
134
134
362
134
362
362
134
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
134
-2.337
-3.046
2.074
-2.657
-0.315
0.098
-0.281
-0.706
-1.156
-0.987
-2.410
0.133
2.810
-3.459
-1.339
0.814
-0.631
-2.255
0.543
-2.647
-2.539
0.061
-0.793
-0.192
1.754
2.199
1.499
1.050
-0.695
-2.042
-1.131
-2.575
0.532
2.044
-4.136
0.636
-1.557
-3.389
0.934
-2.207
-1.958
-3.049
0.584
0.031
-0.536
-1.320
1.096
-2.228
0.622
0.000
-3.449
-0.174
0.519
-0.281
0.275
0.838
2.513
-1.187
3.494
-3.164
-3.154
-2.571
-4.723
1.406
1.491
0.371
-1.148
-2.020
0.017
-1.022
-1.954
1.392
0.153
-3.083
3.180
-1.578
-2.087
-1.542
0.132
-1.026
-2.337
-0.012
-2.536
-2.907
-0.706
-1.598
0.778
-2.647
-2.214
0.090
0.882
0.478
2.264
0.020
-2.256
-0.556
-0.687
-0.573
0.345
0.576
-2.926
-0.465
-2.063
1.631
-3.555
0.046
-0.133
-1.656
-4.158
1.835
-1.814
1.704
-3.249
-2.379
-1.366
-1.594
2.113
-1.824
-2.193
-0.556
-0.725
2.406
-3.233
-2.269
0.399
-2.536
-0.947
-2.359
-3.456
-0.541
2.137
-0.701
-0.532
1.385
0.657
-2.385
-3.092
0.779
-2.268
-2.653
-1.718
0.889
0.570
-2.143
-0.552
-0.784
-2.511
-2.492
-0.397
0.246
1.95E-02
2.32E-03
3.81E-02
7.89E-03
7.53E-01
9.22E-01
7.79E-01
4.80E-01
2.48E-01
3.24E-01
1.59E-02
8.95E-01
4.96E-03
5.42E-04
1.81E-01
4.16E-01
5.28E-01
2.42E-02
5.87E-01
8.13E-03
1.11E-02
9.51E-01
4.28E-01
8.48E-01
7.94E-02
2.79E-02
1.34E-01
2.94E-01
4.87E-01
4.12E-02
2.58E-01
1.00E-02
5.95E-01
4.10E-02
3.54E-05
5.25E-01
1.20E-01
7.02E-04
3.50E-01
2.73E-02
5.03E-02
2.30E-03
5.59E-01
9.75E-01
5.92E-01
1.87E-01
2.73E-01
2.59E-02
5.34E-01
1.00E+00
5.62E-04
8.62E-01
6.04E-01
7.79E-01
7.83E-01
4.02E-01
1.20E-02
2.35E-01
4.75E-04
1.55E-03
1.61E-03
1.02E-02
2.33E-06
1.60E-01
1.36E-01
7.11E-01
2.51E-01
4.34E-02
9.87E-01
3.07E-01
5.07E-02
1.64E-01
8.78E-01
2.05E-03
1.47E-03
1.15E-01
3.69E-02
1.23E-01
8.95E-01
3.05E-01
1.94E-02
9.90E-01
1.12E-02
3.64E-03
4.80E-01
1.10E-01
4.36E-01
8.12E-03
2.68E-02
9.28E-01
3.78E-01
6.33E-01
2.36E-02
9.84E-01
2.41E-02
5.78E-01
4.92E-01
5.67E-01
7.30E-01
5.65E-01
3.43E-03
6.42E-01
3.91E-02
1.03E-01
3.78E-04
9.63E-01
8.95E-01
9.76E-02
3.21E-05
6.65E-02
6.97E-02
8.84E-02
1.16E-03
1.73E-02
1.72E-01
1.11E-01
3.46E-02
6.81E-02
2.83E-02
5.78E-01
4.69E-01
1.61E-02
1.23E-03
2.33E-02
6.90E-01
1.12E-02
3.43E-01
1.83E-02
5.49E-04
5.88E-01
3.26E-02
4.84E-01
5.95E-01
1.66E-01
5.11E-01
1.71E-02
1.99E-03
4.36E-01
2.34E-02
7.98E-03
8.57E-02
3.74E-01
5.69E-01
3.22E-02
5.81E-01
4.33E-01
1.21E-02
1.27E-02
6.92E-01
8.06E-01
23863
55167
7765
22702
2368
52419
64477
27426
59417
60326
16025
8417
59592
50214
100
39231
27635
66929
37226
13742
45460
16221
41081
64865
34877
41740
49796
32538
31937
12810
60098
37742
8292
4766
36478
64740
5527
33972
9697
10941
14588
35276
41354
20951
41291
51782
50957
43610
63897
24000
38303
31705
52432
13560
40910
34608
2144
34596
9389
12193
42154
15399
44782
18127
31692
50194
8234
47216
37419
53996
10449
59671
24175
25116
47533
21304
40921
32237
50330
38619
56635
49266
57370
52989
23000
49602
42474
51213
48712
60831
65554
47304
14843
29366
28877
38787
20916
734
42458
26143
47844
6703
44904
26858
47652
54361
23239
43905
17942
34844
24272
8403
52371
26058
32936
62799
45616
1432
16012
8064
5894
33681
35643
65629
13146
21678
30116
1823
7834
49249
7303
50976
25745
12769
17817
22395
18463
35736
42113
34394
61263
10447
16004
47328
28153
61403
25385
5929
9370
50744
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
9743
22891
1938
4489
57595
51611
84033
55619
55226
10970
27300
123036
151888
7089
10576
56652
51466
356
26354
6194
10538
3394
974
58477
10223
25926
9840
7107
11213
80324
6418
430
84365
79888
126410
9935
3702
8204
80256
5140
112597
134266
90871
1240
117157
302
81929
608
6059
22880
10758
79891
1628
56255
121642
155066
51275
4493
6191
79887
5471
23095
9834
221188
4684
23495
1317
4063
10785
29104
1021
4217
4118
7311
10196
8409
6141
6689
664
84707
383
26140
640
1374
4000
2209
55622
55340
7850
6137
55759
10480
3800
10694
1823
10039
433
824
6772
22849
27346
6237
9209
89857
83853
29993
9933
1803
2672
5341
6352
57509
9341
152007
8445
26270
6228
3423
54865
1955
10100
55163
1802
29799
8725
154141
10128
10231
54482
23082
84306
594
3899
142
6132
257019
930
1879
4839
1117
9334
1939
116369
7453
55356
92935
4830
79872
93979
7923
ARHGAP32
ZNF365
EEF2
MT1A
PDZD4
DPH5
OBSCN
DOCK10
NAT10
CKAP4
ZNF544
TC2N
BTLA
TLE2
CCT2
C10orf2
EVL
FASLG
GNL3
RPS6
BATF
IRF8
CD79B
SRPRB
GPA33
NOL11
TESPA1
GPR137B
IRAK3
PUS1
SET
ASCL2
MKI67IP
LPCAT1
CYP4F22
MAFB
ITK
NRIP1
FAM214B
PDE3B
LINC00152
GRPEL2
C9orf123
CMKLR1
SH2D1B
ANXA2
SEH1L
TNFRSF17
ABCE1
MORC2
TRAF3IP2
ZNF671
DBP
TMX4
ALKBH2
ATP6V0E2
MAPKAPK5-AS1
MT1E
RPS4X
PLBD1
PPAT
KIF1B
KIAA0125
GPR114
NCAM1
TNFRSF13B
SLC31A1
LY9
WDR4
N6AMT1
CDK6
MAP3K5
MAL
UBA52
PRMT3
UXT
RPL18
SPIB
BNIP3
BEX2
ARG1
TTLL3
BLK
CPT1A
LMNA
FCGR1A
TTC27
GIMAP5
IL1R2
RPL13
WDR12
EIF3M
KIF5C
CCT8
DSC1
PARP3
ASGR2
CAPN2
STAT1
CPEB3
TMEM97
RRAS
LRRFIP2
KLHL6
ROPN1L
PACSIN1
KIAA0020
DPP4
GFI1
PLEK
CCL5
MTUS1
VAMP3
GLIPR2
DYRK2
FBXO6
RPS23
IDS
GPATCH4
MEGF9
TSPAN2
PNPO
DPH2
YPEL1
URI1
MBOAT1
LRPPRC
RCAN2
TRMT13
PPRC1
PDCD2L
BCKDHB
AFF3
PARP1
RPL8
FRMD3
CD19
EBF1
NOP2
CHI3L2
B4GALT5
EIF2D
SLC26A8
WARS
SLC22A15
MARS2
NME1
CBLL1
CPA5
HSD17B8
-----++-+++
-----++++++
++-+++
--------------------++++++
-----------------------+-----------++-+++
----------++-+++
------------------------------++-+++
++++++
----------++++++
--+--++--++
++++++
++++++
----------++++++
-----++-+++
----------++-+++
++++++
++++++
-------+---------------------------++++++
---------------++++++
-----+
++++++
-----+-+-++
-----++-+++
++++++
-----++++++
----------+
----------++++++
----------------------------------------++++++
+++?++
-----+-++++
++++++
++++++
----------++++++
------------------------------++-+++
++++++
++-+-+
++++++
++++++
-----++++++
++++++
-----++++++
-----+
----------++-+++
++++++
++-+++
---+-++++-+
++++++
-----++++++
---?-++++++
-----++++++
++++++
---+------+
++++++
-----++++-+
-----++++++
---------------------------------?-++++++
----------------+-?-++++++
-----++++++
++++++
++++++
--------------------------
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-8.356
9.664
-10.416
9.646
8.255
-10.600
-8.249
-10.659
-10.799
9.966
-10.202
-9.248
-9.919
-7.861
-9.816
-8.994
-10.099
8.926
-9.720
-9.996
9.018
-9.254
-8.299
-10.121
-10.560
-9.217
-11.236
8.630
9.088
-8.866
-8.423
10.542
-9.288
9.620
7.785
8.032
-11.487
-8.223
6.945
-9.914
6.989
-10.395
-8.606
8.410
7.196
9.998
-9.922
-7.335
-9.484
-9.916
-8.258
-9.442
-7.515
8.482
-9.317
-8.504
-9.104
8.775
-8.860
9.601
-11.028
8.163
-9.236
10.117
7.638
-7.783
10.101
-10.365
-7.786
-8.220
-9.790
8.793
-9.972
-8.559
-8.707
-8.934
-9.643
-6.838
-9.189
-9.519
9.782
8.344
-6.504
9.351
8.041
8.990
-9.298
-10.453
8.538
-7.880
-8.547
-7.541
-11.700
-9.168
-8.647
9.000
10.715
6.913
8.737
8.266
-8.142
8.783
9.704
-8.642
10.182
-8.399
-9.815
-10.740
8.668
8.391
8.674
-7.269
9.290
9.322
-8.856
8.975
-7.492
8.051
-9.745
8.560
7.401
-7.203
-6.936
9.572
-9.121
7.891
-9.398
10.595
-8.255
-8.580
-8.020
-8.655
-8.986
-9.330
-7.835
8.501
-6.369
-8.696
-9.373
-6.651
8.098
-8.665
8.705
8.844
8.537
-9.638
-7.748
-9.175
-7.640
-8.093
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
6.49E-17
4.29E-22
2.10E-25
5.11E-22
1.52E-16
2.97E-26
1.59E-16
1.59E-26
3.47E-27
2.15E-23
1.95E-24
2.28E-20
3.44E-23
3.82E-15
9.60E-23
2.38E-19
5.57E-24
4.43E-19
2.48E-22
1.59E-23
1.92E-19
2.15E-20
1.05E-16
4.45E-24
4.57E-26
3.07E-20
2.73E-29
6.14E-18
1.01E-19
7.60E-19
3.66E-17
5.52E-26
1.57E-20
6.56E-22
6.96E-15
9.58E-16
1.54E-30
1.99E-16
3.79E-12
3.61E-23
2.76E-12
2.62E-25
7.57E-18
4.11E-17
6.19E-13
1.55E-23
3.35E-23
2.22E-13
2.44E-21
3.54E-23
1.48E-16
3.65E-21
5.69E-14
2.20E-17
1.20E-20
1.84E-17
8.69E-20
1.71E-18
8.00E-19
7.92E-22
2.80E-28
3.27E-16
2.56E-20
4.66E-24
2.20E-14
7.09E-15
5.45E-24
3.56E-25
6.89E-15
2.03E-16
1.24E-22
1.46E-18
2.01E-23
1.14E-17
3.11E-18
4.12E-19
5.25E-22
8.06E-12
3.96E-20
1.75E-21
1.34E-22
7.21E-17
7.82E-11
8.70E-21
8.88E-16
2.47E-19
1.43E-20
1.41E-25
1.37E-17
3.26E-15
1.26E-17
4.65E-14
1.27E-31
4.83E-20
5.30E-18
2.25E-19
8.68E-27
4.74E-12
2.39E-18
1.38E-16
3.90E-16
1.59E-18
2.91E-22
5.53E-18
2.39E-24
4.52E-17
9.66E-23
6.60E-27
4.41E-18
4.81E-17
4.18E-18
3.62E-13
1.55E-20
1.14E-20
8.31E-19
2.83E-19
6.78E-14
8.19E-16
1.93E-22
1.13E-17
1.35E-13
5.89E-13
4.02E-12
1.05E-21
7.44E-20
3.00E-15
5.54E-21
3.16E-26
1.51E-16
9.49E-18
1.06E-15
4.92E-18
2.56E-19
1.06E-20
4.70E-15
1.88E-17
1.90E-10
3.45E-18
7.05E-21
2.91E-11
5.57E-16
4.52E-18
3.19E-18
9.25E-19
1.37E-17
5.52E-22
9.37E-15
4.51E-20
2.17E-14
5.83E-16
-----+-?+++++?+
--------+++++++
++++++++
------------+---------------++++++++
-----------------+-------------------------------++++++++
--------------++++++++
----+-----+----------------+---------------+++++++
+++-++++
--------------+++-++++
-------++++++-+
++++++++
++++-+++
-------+
--+----++++++++
-------++++++++
---+----------?++++??+
++++++++
++++--++
-----------+---------------------------------+---++++++-+
---+-----------------++++++++
-------++++++-+
-------++++++++
----+---+++++++
++++-+++
-------++++++++
-----+----------------------++++++++
---+---+
---------+---------------------+-----------------++++++-+
+++-++++
--------++-+-?+
++++--++
++++++++
--------------++++++-+
---------------------+--+--+-------------?++++++++
+-+++-++
+++++-++
+++-++++
++++++++
----+--+++++-++
++++++++
-------+++-++++
-----+--------------+++++++++
+++-++++
++++++++
?----??++++++++
++++++++
-------++++++++
-------++++++++
-------+++-++-+
+++++-++
-----------+---+++++++
-------+-++++++
-------?++++??+
-------------------------------+------+---+
-------+++++-++
---+------+---------------+-++++++++
----+--+++-++++
++++++++
+++-++-+
---------+-----------------?--------
8009
5590
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
-9.91
8.60
-7.92
8.63
9.94
-7.71
-9.94
-7.62
-7.47
8.24
-7.99
-8.89
-8.21
-10.16
-8.28
-9.05
-7.98
9.10
-8.30
-8.01
8.93
-8.66
-9.56
-7.78
-7.30
-8.57
-6.64
9.10
8.66
-8.87
-9.28
7.18
-8.35
8.01
9.74
9.47
-6.18
-9.21
10.40
-7.57
10.35
-7.09
-8.78
9.05
10.06
7.39
-7.43
-9.88
-7.83
-7.40
-8.97
-7.82
-9.63
8.68
-7.87
-8.64
-8.06
8.35
-8.25
7.54
-6.16
8.88
-7.85
7.01
9.36
-9.22
7.00
-6.74
-9.18
-8.75
-7.25
8.19
-7.05
-8.36
-8.21
-7.98
-7.28
-9.94
-7.70
-7.38
7.12
8.50
-10.22
7.41
8.74
7.80
-7.51
-6.40
8.21
-8.83
-8.19
-9.15
-5.17
-7.55
-8.01
7.68
6.01
9.62
7.87
8.31
-8.41
7.78
6.90
-7.91
6.44
-8.12
-6.76
-5.87
7.83
8.09
7.82
-9.39
7.18
7.14
-7.57
7.45
-8.81
8.29
-6.67
7.77
8.87
-9.06
-9.31
6.79
-7.21
8.38
-6.94
5.32
-8.01
-7.69
-8.22
-7.61
-7.29
-6.96
-8.39
7.75
-9.76
-7.55
-6.90
-9.42
8.09
-7.55
7.51
7.34
7.61
-6.55
-8.34
-6.96
-8.44
-7.96
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
3.90E-23
8.26E-18
2.47E-15
5.93E-18
2.76E-23
1.31E-14
2.88E-23
2.62E-14
8.36E-14
1.73E-16
1.40E-15
6.01E-19
2.15E-16
3.07E-24
1.26E-16
1.41E-19
1.44E-15
9.49E-20
1.02E-16
1.17E-15
4.35E-19
4.87E-18
1.21E-21
7.40E-15
2.89E-13
1.06E-17
3.17E-11
8.85E-20
4.68E-18
7.19E-19
1.77E-20
6.85E-13
7.03E-17
1.18E-15
2.01E-22
2.78E-21
6.52E-10
3.26E-20
2.50E-25
3.70E-14
4.07E-25
1.30E-12
1.59E-18
1.44E-19
8.29E-24
1.51E-13
1.12E-13
4.86E-23
4.81E-15
1.32E-13
3.04E-19
5.46E-15
5.97E-22
4.13E-18
3.68E-15
5.81E-18
7.83E-16
7.15E-17
1.60E-16
4.58E-14
7.47E-10
6.83E-19
4.14E-15
2.40E-12
8.04E-21
2.93E-20
2.53E-12
1.63E-11
4.28E-20
2.13E-18
4.32E-13
2.66E-16
1.78E-12
6.40E-17
2.18E-16
1.52E-15
3.26E-13
2.73E-23
1.39E-14
1.59E-13
1.06E-12
1.90E-17
1.63E-24
1.23E-13
2.40E-18
6.19E-15
6.08E-14
1.56E-10
2.15E-16
1.08E-18
2.58E-16
5.78E-20
2.30E-07
4.22E-14
1.15E-15
1.62E-14
1.87E-09
6.53E-22
3.57E-15
9.31E-17
4.07E-17
7.20E-15
5.09E-12
2.58E-15
1.20E-10
4.53E-16
1.35E-11
4.26E-09
4.90E-15
6.10E-16
5.38E-15
5.76E-21
6.91E-13
9.50E-13
3.84E-14
9.46E-14
1.26E-18
1.11E-16
2.50E-11
7.96E-15
7.34E-19
1.36E-19
1.30E-20
1.15E-11
5.57E-13
5.34E-17
3.86E-12
1.06E-07
1.15E-15
1.44E-14
2.11E-16
2.74E-14
3.06E-13
3.30E-12
4.98E-17
9.27E-15
1.67E-22
4.54E-14
5.26E-12
4.62E-21
5.82E-16
4.25E-14
5.94E-14
2.20E-13
2.79E-14
5.87E-11
7.56E-17
3.31E-12
3.23E-17
1.73E-15
15266
12847
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12620
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
13809
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13809
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12620
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12620
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
13809
15266
-12.937
12.933
-12.914
12.904
12.892
-12.889
-12.885
-12.865
-12.852
12.839
-12.818
-12.817
-12.788
-12.777
-12.763
-12.757
-12.745
12.741
-12.715
-12.692
12.684
-12.651
-12.644
-12.612
-12.568
-12.56
-12.555
12.543
12.539
-12.539
-12.526
12.471
-12.449
12.432
12.423
12.398
-12.394
-12.34
12.321
-12.319
12.318
-12.305
-12.295
12.276
12.248
12.244
-12.219
-12.217
-12.212
-12.2
-12.189
-12.171
-12.157
12.132
-12.121
-12.118
-12.113
12.094
-12.083
12.083
-12.062
12.058
-12.054
12.052
12.045
-12.045
12.036
-12.026
-12.018
-12.006
-11.998
11.993
-11.983
-11.955
-11.951
-11.936
-11.924
-11.915
-11.911
-11.908
11.904
11.897
-11.886
11.885
11.872
11.848
-11.848
-11.843
11.836
-11.827
-11.826
-11.826
-11.814
-11.792
-11.786
11.767
11.74
11.735
11.724
11.721
-11.706
11.692
11.69
-11.687
11.684
-11.675
-11.666
-11.659
11.647
11.643
11.643
-11.636
11.606
11.597
-11.586
11.583
-11.561
11.557
-11.553
11.528
11.527
-11.525
-11.525
11.515
-11.511
11.51
-11.508
11.499
-11.494
-11.488
-11.48
-11.48
-11.477
-11.477
-11.474
11.474
-11.461
-11.46
-11.459
-11.455
11.445
-11.445
11.441
11.411
11.397
-11.387
-11.381
-11.37
-11.351
-11.345
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.80E-38
2.91E-38
3.73E-38
4.26E-38
5.00E-38
5.17E-38
5.46E-38
7.08E-38
8.34E-38
9.90E-38
1.31E-37
1.32E-37
1.91E-37
2.21E-37
2.63E-37
2.84E-37
3.34E-37
3.48E-37
4.87E-37
6.57E-37
7.26E-37
1.11E-36
1.20E-36
1.82E-36
3.17E-36
3.51E-36
3.74E-36
4.35E-36
4.57E-36
4.58E-36
5.39E-36
1.08E-35
1.41E-35
1.75E-35
1.95E-35
2.69E-35
2.82E-35
5.50E-35
7.02E-35
7.12E-35
7.28E-35
8.47E-35
9.60E-35
1.21E-34
1.72E-34
1.82E-34
2.45E-34
2.53E-34
2.69E-34
3.11E-34
3.57E-34
4.42E-34
5.29E-34
7.14E-34
8.22E-34
8.46E-34
9.04E-34
1.14E-33
1.29E-33
1.29E-33
1.67E-33
1.75E-33
1.84E-33
1.90E-33
2.05E-33
2.05E-33
2.30E-33
2.61E-33
2.85E-33
3.32E-33
3.65E-33
3.87E-33
4.38E-33
6.14E-33
6.39E-33
7.67E-33
8.87E-33
9.84E-33
1.04E-32
1.08E-32
1.13E-32
1.23E-32
1.40E-32
1.41E-32
1.65E-32
2.20E-32
2.21E-32
2.35E-32
2.56E-32
2.85E-32
2.85E-32
2.87E-32
3.30E-32
4.27E-32
4.64E-32
5.81E-32
7.98E-32
8.44E-32
9.63E-32
9.96E-32
1.19E-31
1.41E-31
1.43E-31
1.48E-31
1.54E-31
1.72E-31
1.90E-31
2.06E-31
2.37E-31
2.48E-31
2.50E-31
2.70E-31
3.83E-31
4.26E-31
4.84E-31
5.03E-31
6.49E-31
6.77E-31
7.15E-31
9.49E-31
9.62E-31
9.84E-31
9.92E-31
1.11E-30
1.16E-30
1.18E-30
1.20E-30
1.33E-30
1.42E-30
1.52E-30
1.66E-30
1.67E-30
1.72E-30
1.72E-30
1.78E-30
1.79E-30
2.08E-30
2.10E-30
2.12E-30
2.22E-30
2.48E-30
2.49E-30
2.62E-30
3.68E-30
4.34E-30
4.84E-30
5.20E-30
5.90E-30
7.35E-30
7.87E-30
+
+
+
?
?
?
+
?
?
?
+
?
+
?
?
?
?
+
?
?
+
?
+
?
?
?
+
?
?
+
?
?
?
+
+
?
+
+
?
+
+
+
?
+
?
?
+
+
?
?
?
?
?
?
?
?
?
+
?
?
?
+
?
?
+
?
?
?
?
+
?
+
+
?
?
?
?
+
+
+
+
?
?
+
+
?
?
?
?
?
?
?
?
?
?
?
+
?
+
?
+
?
+
+
?
?
+
+
?
+
+
+
?
?
?
?
394
394
394
394
0
0
0
394
394
394
0
0
0
394
394
0
394
0
394
394
0
394
0
394
0
394
0
394
0
394
394
0
394
394
0
0
0
394
394
0
0
394
0
0
0
394
394
0
394
394
394
0
394
394
394
394
0
394
0
0
394
394
0
0
394
0
394
0
0
0
394
0
394
0
394
0
394
0
394
0
0
394
0
0
394
0
0
0
0
394
0
394
394
394
0
0
0
0
394
394
394
394
394
0
0
394
394
0
0
0
0
394
394
394
0
0
0
0
0
0
0
394
0
394
394
0
394
394
0
394
394
394
394
0
394
394
0
394
394
0
394
394
394
394
0
0
394
394
0
0
0.003
0.008
-0.008
0.010
ns
ns
ns
-0.013
0.018
-0.010
ns
ns
ns
0.013
-0.007
ns
0.005
ns
0.000
-0.002
ns
-0.003
ns
-0.003
ns
0.009
ns
-0.024
ns
0.012
-0.006
ns
-0.005
0.007
ns
ns
ns
-0.005
0.005
ns
ns
0.000
ns
ns
ns
0.008
0.002
ns
-0.004
0.008
0.005
ns
0.002
0.000
0.008
-0.006
ns
0.008
ns
ns
0.012
0.004
ns
ns
-0.003
ns
-0.004
ns
ns
ns
-0.014
ns
-0.010
ns
-0.001
ns
0.003
ns
-0.008
ns
ns
0.008
ns
ns
0.002
ns
ns
ns
ns
0.001
ns
-0.009
0.001
0.000
ns
ns
ns
ns
0.002
0.010
-0.004
0.008
0.003
ns
ns
0.008
0.003
ns
ns
ns
ns
-0.014
-0.004
-0.001
ns
ns
ns
ns
ns
ns
ns
0.008
ns
0.014
-0.007
ns
0.002
-0.005
ns
0.008
0.001
-0.011
-0.009
ns
-0.003
-0.010
ns
0.003
0.013
ns
-0.003
0.001
0.011
0.005
ns
ns
-0.010
-0.003
ns
ns
0.003
0.003
0.003
0.003
ns
ns
ns
0.004
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
ns
0.003
0.003
ns
0.004
ns
0.003
ns
0.004
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
ns
ns
0.004
0.003
ns
ns
0.003
ns
ns
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
0.003
0.004
ns
ns
0.003
ns
0.003
ns
ns
ns
0.003
ns
0.004
ns
0.003
ns
0.003
ns
0.003
ns
ns
0.003
ns
ns
0.003
ns
ns
ns
ns
0.003
ns
0.003
0.003
0.004
ns
ns
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
ns
ns
0.003
0.003
0.004
ns
ns
ns
ns
ns
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.004
ns
0.003
0.003
ns
0.004
0.003
0.003
0.004
ns
ns
0.003
0.003
ns
ns
3.59E-01
8.13E-03
2.57E-03
3.57E-04
ns
ns
ns
2.54E-04
1.92E-09
2.48E-03
ns
ns
ns
3.37E-06
4.05E-02
ns
1.25E-01
ns
9.40E-01
4.72E-01
ns
3.78E-01
ns
3.53E-01
ns
1.60E-02
ns
2.45E-12
ns
5.96E-05
3.62E-02
ns
1.70E-01
1.33E-02
ns
ns
ns
1.28E-01
1.53E-01
ns
ns
9.97E-01
ns
ns
ns
2.09E-02
6.21E-01
ns
2.40E-01
1.29E-02
6.22E-02
ns
5.32E-01
9.81E-01
1.57E-02
5.87E-02
ns
6.55E-03
ns
ns
5.18E-04
3.13E-01
ns
ns
3.14E-01
ns
1.95E-01
ns
ns
ns
2.81E-05
ns
6.64E-03
ns
7.40E-01
ns
3.29E-01
ns
1.94E-02
ns
ns
1.61E-02
ns
ns
4.86E-01
ns
ns
ns
ns
8.11E-01
ns
1.91E-03
8.33E-01
9.82E-01
ns
ns
ns
ns
4.55E-01
3.99E-03
2.22E-01
2.25E-02
3.04E-01
ns
ns
1.76E-02
3.55E-01
ns
ns
ns
ns
6.27E-07
2.30E-01
8.05E-01
ns
ns
ns
ns
ns
ns
ns
1.55E-02
ns
6.43E-06
3.05E-02
ns
5.38E-01
1.35E-01
ns
1.50E-02
8.20E-01
5.84E-04
2.52E-03
ns
4.08E-01
5.95E-03
ns
3.22E-01
3.28E-06
ns
3.67E-01
6.32E-01
3.89E-04
1.75E-01
ns
ns
4.11E-04
3.80E-01
ns
ns
+
+
?
?
?
+
+
?
?
?
+
?
?
+
?
+
+
?
+
?
+
?
+
?
?
+
?
+
?
?
?
+
?
+
+
?
+
?
+
?
?
+
+
?
?
?
?
?
?
+
?
+
?
+
?
+
?
?
?
+
?
?
+
?
?
?
?
+
?
?
?
?
?
+
+
+
+
+
?
?
?
?
?
?
+
+
+
?
+
?
?
?
?
?
?
?
+
?
+
+
?
+
?
?
+
?
+
+
?
?
?
-
394
394
394
394
0
0
0
394
394
394
0
0
0
394
394
0
394
0
394
394
0
394
394
394
0
394
394
394
0
394
394
0
394
394
0
394
0
394
394
0
394
394
0
0
0
394
394
0
394
394
394
0
394
394
394
394
0
394
0
0
394
394
0
0
394
0
394
0
0
0
394
0
394
0
394
0
394
0
394
0
0
394
0
0
394
0
0
0
0
394
0
394
394
394
0
0
0
0
394
394
394
394
394
0
0
394
394
0
0
0
0
394
394
394
0
394
0
0
0
0
0
394
0
394
394
0
394
394
0
394
394
394
394
0
394
394
0
0
394
0
394
394
394
394
0
0
394
394
0
394
-0.010
0.005
-0.003
0.012
ns
ns
ns
0.002
0.020
-0.018
ns
ns
ns
0.017
-0.011
ns
-0.006
ns
-0.013
0.003
ns
-0.014
0.000
0.002
ns
0.002
-0.006
-0.003
ns
0.018
-0.012
ns
-0.007
0.000
ns
-0.013
ns
-0.013
0.015
ns
0.002
-0.001
ns
ns
ns
0.008
-0.005
ns
-0.005
0.009
0.008
ns
-0.005
-0.006
0.012
-0.010
ns
0.012
ns
ns
0.002
0.010
ns
ns
-0.012
ns
-0.006
ns
ns
ns
0.006
ns
0.008
ns
0.004
ns
0.010
ns
-0.005
ns
ns
0.016
ns
ns
0.011
ns
ns
ns
ns
0.003
ns
-0.013
-0.007
-0.006
ns
ns
ns
ns
0.011
0.007
0.002
0.012
0.014
ns
ns
-0.008
-0.006
ns
ns
ns
ns
0.003
0.009
0.011
ns
0.007
ns
ns
ns
ns
ns
-0.003
ns
-0.014
-0.002
ns
-0.003
0.004
ns
0.015
0.001
-0.004
-0.004
ns
0.007
-0.002
ns
ns
0.017
ns
-0.009
0.013
0.002
-0.003
ns
ns
-0.007
-0.003
ns
-0.002
0.003
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
0.002
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
0.004
0.003
ns
ns
0.003
ns
0.003
ns
ns
ns
0.004
ns
0.003
ns
0.003
ns
0.003
ns
0.003
ns
ns
0.003
ns
ns
0.004
ns
ns
ns
ns
0.003
ns
0.003
0.003
0.003
ns
ns
ns
ns
0.003
0.003
0.004
0.003
0.003
ns
ns
0.003
0.003
ns
ns
ns
ns
0.004
0.003
0.003
ns
0.003
ns
ns
ns
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
0.004
ns
ns
0.003
0.003
ns
0.004
3.05E-03
1.63E-01
3.45E-01
5.06E-05
ns
ns
ns
4.96E-01
1.32E-11
1.68E-07
ns
ns
ns
9.07E-08
8.17E-04
ns
6.22E-02
ns
3.71E-05
2.55E-01
ns
3.61E-05
8.89E-01
4.75E-01
ns
5.87E-01
7.67E-02
3.34E-01
ns
4.07E-10
2.47E-06
ns
3.55E-02
9.87E-01
ns
7.46E-05
ns
3.02E-04
1.19E-05
ns
5.27E-01
7.86E-01
ns
ns
ns
9.23E-03
1.05E-01
ns
9.14E-02
1.14E-02
5.69E-03
ns
1.46E-01
5.88E-02
1.95E-04
1.24E-03
ns
7.50E-05
ns
ns
5.43E-01
2.01E-03
ns
ns
8.28E-06
ns
6.13E-02
ns
ns
ns
8.18E-02
ns
1.69E-02
ns
2.43E-01
ns
1.99E-03
ns
1.43E-01
ns
ns
7.69E-08
ns
ns
1.46E-03
ns
ns
ns
ns
2.36E-01
ns
2.49E-05
2.97E-02
1.04E-01
ns
ns
ns
ns
1.32E-04
2.75E-02
6.69E-01
2.35E-04
1.02E-07
ns
ns
2.39E-02
5.80E-02
ns
ns
ns
ns
4.42E-01
1.12E-02
1.72E-03
ns
2.91E-02
ns
ns
ns
ns
ns
4.15E-01
ns
7.99E-06
5.49E-01
ns
3.10E-01
2.32E-01
ns
1.21E-05
7.58E-01
2.11E-01
2.27E-01
ns
3.07E-02
4.68E-01
ns
ns
1.60E-09
ns
9.03E-03
2.66E-05
4.19E-01
3.66E-01
ns
ns
3.25E-02
3.12E-01
ns
6.72E-01
?
++
-++
+?
??-??+
----+++?+
++++
-++
?-+?++
?+
++
-++
-++
?+
++
+-++
++?
--?+
-++
??++-+
--++
--?++
+?
-?
-?+
?+
++
++
?+
-?-?-++
+---?
+?+
--?
-+
++
-+
++
++
?+
++++
-??++
+++
++
?+
++
---++
++--+
+++
-+
++
++
?
+++
-+
?+
-?
++
?+
?+
++?+
+++
+?+
?++
---+?--+
?--++
--+
??+
?+
--+
-?-
0
515
515
515
302
213
213
515
213
213
515
515
515
515
515
515
515
213
515
515
515
515
515
213
515
515
213
515
213
515
515
515
515
515
213
515
515
515
515
515
302
515
515
213
515
515
213
213
515
515
515
515
515
515
515
515
213
515
302
302
515
213
213
515
515
213
515
213
515
213
515
515
515
515
515
302
515
213
515
302
515
515
515
515
515
213
515
515
515
515
213
213
515
515
515
515
213
515
515
515
515
515
515
515
515
515
515
515
515
515
515
0
515
515
515
213
515
0
515
213
213
515
515
213
515
515
515
213
213
515
515
515
515
515
213
515
515
213
515
515
515
515
515
213
213
213
515
515
515
213
ns
5.649
-1.021
1.770
3.427
-2.306
-1.876
-0.869
-2.347
1.836
-0.560
-1.169
-1.109
-2.111
-0.859
-0.578
-0.034
4.227
-0.760
-0.750
5.101
-3.858
0.339
-1.918
-5.689
-0.633
-1.001
1.684
0.697
1.750
-1.077
2.752
-1.221
2.215
2.306
1.486
0.621
-5.121
2.193
-0.084
2.863
-2.038
-0.813
1.711
-1.356
5.131
-1.163
-2.088
-0.639
-0.826
-0.004
-3.611
-2.658
1.474
-1.583
-1.156
-2.527
2.605
0.988
-0.365
-2.826
1.946
0.472
3.853
2.132
1.612
-2.837
-2.478
-1.548
-2.389
-0.623
3.168
-0.275
-4.381
-2.442
-1.751
0.108
0.793
-3.809
-1.221
0.555
3.047
-0.972
3.939
3.080
0.478
-0.399
0.090
1.188
-0.951
-1.990
-2.137
2.027
0.236
0.539
4.550
1.687
4.880
-1.010
-1.103
-1.607
1.726
0.902
-0.967
-0.096
-1.370
-0.478
1.281
0.612
2.920
4.423
ns
0.741
3.537
-2.244
1.203
-1.381
ns
1.139
2.126
3.662
-0.554
0.848
2.562
0.265
1.574
-0.152
0.878
-1.248
1.947
-1.713
-2.102
-9.575
0.979
-0.546
-0.641
-0.613
-0.840
-1.905
-5.543
2.390
-2.646
-0.706
-0.581
2.364
0.913
-2.191
-0.399
-0.948
-1.585
ns
1.62E-08
3.07E-01
7.67E-02
6.10E-04
2.11E-02
6.07E-02
3.85E-01
1.89E-02
6.64E-02
5.75E-01
2.43E-01
2.68E-01
3.48E-02
3.90E-01
5.63E-01
9.73E-01
2.37E-05
4.47E-01
4.53E-01
3.39E-07
1.15E-04
7.34E-01
5.51E-02
1.28E-08
5.27E-01
3.17E-01
9.21E-02
4.86E-01
8.01E-02
2.82E-01
5.92E-03
2.22E-01
2.67E-02
2.11E-02
1.37E-01
5.34E-01
3.04E-07
2.83E-02
9.33E-01
4.20E-03
4.15E-02
4.17E-01
8.71E-02
1.75E-01
2.88E-07
2.45E-01
3.68E-02
5.23E-01
4.09E-01
9.97E-01
3.05E-04
7.87E-03
1.41E-01
1.14E-01
2.48E-01
1.15E-02
9.18E-03
3.23E-01
7.15E-01
4.72E-03
5.16E-02
6.37E-01
1.17E-04
3.30E-02
1.07E-01
4.55E-03
1.32E-02
1.22E-01
1.69E-02
5.33E-01
1.54E-03
7.83E-01
1.18E-05
1.46E-02
8.00E-02
9.14E-01
4.28E-01
1.40E-04
2.22E-01
5.79E-01
2.31E-03
3.31E-01
8.17E-05
2.07E-03
6.33E-01
6.90E-01
9.29E-01
2.35E-01
3.41E-01
4.66E-02
3.26E-02
4.27E-02
8.13E-01
5.90E-01
5.37E-06
9.16E-02
1.06E-06
3.12E-01
2.70E-01
1.08E-01
8.44E-02
3.67E-01
3.34E-01
9.24E-01
1.71E-01
6.32E-01
2.00E-01
5.40E-01
3.50E-03
9.73E-06
ns
4.59E-01
4.04E-04
2.48E-02
2.29E-01
1.67E-01
ns
2.55E-01
3.35E-02
2.50E-04
5.79E-01
3.96E-01
1.04E-02
7.91E-01
1.16E-01
8.79E-01
3.80E-01
2.12E-01
5.15E-02
8.67E-02
3.56E-02
1.02E-21
3.28E-01
5.85E-01
5.21E-01
5.40E-01
4.01E-01
5.68E-02
2.97E-08
1.68E-02
8.15E-03
4.80E-01
5.61E-01
1.81E-02
3.61E-01
2.84E-02
6.90E-01
3.43E-01
1.13E-01
?
+
+
?
?
?
?
+
+
+
+
?
+
?
+
?
+
+
+
+
+
+
?
+
+
?
?
+
?
+
+
?
?
+
+
?
?
?
+
?
+
+
+
?
+
?
?
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
?
?
?
?
?
+
+
?
?
+
?
+
+
+
?
+
?
?
0
299
299
299
299
0
0
299
0
0
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
0
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
0
0
299
299
299
299
299
299
299
299
0
299
299
299
299
0
0
299
299
0
299
0
299
0
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
0
299
299
299
299
0
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
0
299
0
299
0
0
299
299
0
299
299
299
299
0
299
299
299
299
299
0
299
299
0
299
299
299
299
299
0
299
0
299
299
299
0
ns
0.020
-0.014
-0.007
0.038
ns
ns
-0.021
ns
ns
-0.014
-0.012
-0.008
-0.010
-0.009
-0.004
-0.001
0.004
-0.012
-0.010
0.016
0.003
0.003
ns
0.002
-0.012
ns
0.010
ns
-0.015
-0.015
0.018
-0.018
0.017
0.006
0.022
-0.001
-0.031
0.018
-0.032
0.047
-0.008
-0.022
ns
0.001
0.040
ns
ns
-0.017
-0.006
-0.028
-0.023
-0.010
0.009
-0.010
-0.016
ns
0.005
-0.022
0.025
-0.006
ns
ns
0.022
0.010
ns
-0.001
ns
-0.011
ns
-0.007
0.022
-0.052
-0.025
-0.020
-0.025
-0.012
ns
-0.019
-0.031
0.010
0.016
-0.020
0.007
-0.004
ns
-0.017
-0.016
0.034
-0.025
ns
ns
-0.004
-0.012
-0.009
0.003
0.007
0.010
0.003
0.001
-0.014
0.006
0.014
-0.008
0.006
0.005
-0.006
-0.011
0.021
0.044
0.038
ns
0.009
0.030
-0.022
ns
-0.029
ns
-0.008
ns
ns
-0.006
-0.011
ns
-0.006
0.005
-0.004
0.012
ns
-0.004
-0.007
-0.003
-0.006
-0.006
ns
0.004
-0.002
ns
0.001
-0.005
0.022
-0.026
0.005
ns
0.006
ns
-0.021
-0.007
-0.004
ns
ns
0.004
0.004
0.007
0.008
ns
ns
0.008
ns
ns
0.004
0.008
0.003
0.003
0.004
0.002
0.005
0.002
0.005
0.004
0.005
0.007
0.009
ns
0.003
0.005
ns
0.004
ns
0.005
0.008
0.008
0.007
0.004
0.003
0.010
0.006
0.005
0.006
0.008
0.007
0.005
0.006
ns
0.003
0.007
ns
ns
0.007
0.002
0.005
0.004
0.002
0.004
0.003
0.006
ns
0.006
0.010
0.009
0.003
ns
ns
0.006
0.003
ns
0.002
ns
0.004
ns
0.005
0.005
0.010
0.005
0.007
0.005
0.004
ns
0.004
0.007
0.004
0.006
0.005
0.002
0.009
ns
0.006
0.007
0.011
0.005
ns
ns
0.005
0.006
0.003
0.004
0.003
0.004
0.007
0.003
0.003
0.005
0.004
0.003
0.004
0.004
0.004
0.005
0.006
0.013
0.009
ns
0.004
0.007
0.006
ns
0.011
ns
0.003
ns
ns
0.004
0.004
ns
0.006
0.004
0.004
0.003
ns
0.004
0.003
0.002
0.002
0.005
ns
0.002
0.004
ns
0.005
0.004
0.007
0.005
0.003
ns
0.002
ns
0.005
0.007
0.003
ns
ns
5.64E-06
1.02E-03
3.21E-01
8.91E-06
ns
ns
1.24E-02
ns
ns
1.34E-03
1.16E-01
9.85E-03
1.49E-03
1.86E-02
4.86E-02
8.77E-01
3.38E-02
3.21E-02
2.35E-02
4.67E-04
5.98E-01
7.14E-01
ns
5.53E-01
2.19E-02
ns
1.49E-02
ns
3.55E-03
7.97E-02
2.99E-02
6.45E-03
6.22E-05
9.22E-02
2.01E-02
8.60E-01
4.69E-09
4.49E-03
3.88E-05
5.13E-10
8.61E-02
3.93E-04
ns
7.28E-01
1.30E-07
ns
ns
1.38E-02
1.25E-02
8.09E-08
3.58E-08
5.24E-05
3.47E-02
4.92E-04
4.18E-03
ns
3.46E-01
2.34E-02
5.12E-03
6.81E-02
ns
ns
3.92E-04
7.33E-04
ns
7.63E-01
ns
4.06E-03
ns
1.75E-01
1.14E-05
6.04E-07
1.33E-07
3.05E-03
1.55E-06
3.62E-03
ns
3.49E-05
1.38E-05
1.13E-02
7.24E-03
4.53E-05
5.49E-03
6.86E-01
ns
3.04E-03
2.79E-02
1.67E-03
6.49E-07
ns
ns
3.85E-01
5.95E-02
8.21E-04
5.25E-01
9.54E-03
6.28E-03
7.08E-01
6.60E-01
4.07E-05
2.22E-01
6.03E-04
7.14E-03
6.60E-02
2.64E-01
1.40E-01
3.65E-02
2.69E-04
8.17E-04
5.12E-05
ns
4.71E-02
2.29E-05
8.73E-05
ns
9.09E-03
ns
4.28E-03
ns
ns
1.50E-01
7.35E-03
ns
3.48E-01
2.47E-01
2.51E-01
1.34E-04
ns
3.17E-01
9.79E-03
2.34E-01
4.71E-03
2.43E-01
ns
8.57E-02
6.22E-01
ns
8.82E-01
2.04E-01
2.60E-03
6.32E-08
5.77E-02
ns
1.19E-02
ns
1.63E-05
3.33E-01
9.17E-02
ns
?+?
++
++
?-+?
-+
-+
+---+?
--?
-+
++
--+-+-++
----+
++
-+
++
-+++
++
+-+
++
-+
?--?
++-----+
-+
--+
-+
-++
-?
++
??+
--+
++++
+---+
+?
-+
-+
---?-+-?+?
-+
+-+
++
++
--+
++
+--+-+
+?
++
+-+
-+
-+
--+
-+
-+
++
+-+
-+
+?
-++
?
-+
-+
-+
+-?+++
++
-+++
-?
-+
-+?
--+
+---+
+++
++-+
+++
-++
++
-+
+--+
+?
--
354
213
567
567
354
567
213
567
567
567
567
567
567
213
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
354
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
354
354
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
354
567
567
567
354
213
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
0
567
567
567
567
567
354
567
567
567
567
567
567
213
567
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
-0.196
1.820
1.386
3.793
-0.043
-3.637
2.118
0.138
-0.927
-0.431
-0.554
-0.821
-1.445
1.761
-4.842
-0.626
1.451
1.968
-4.212
-5.789
0.010
-1.337
-1.684
-3.958
0.409
-3.703
-0.855
-0.618
0.830
2.151
-1.206
1.092
-4.723
1.298
2.181
4.600
-0.804
2.293
2.441
0.879
-2.867
-1.187
-0.187
1.087
0.104
-0.897
-1.911
-1.291
-5.544
-0.434
2.569
-0.500
-0.077
0.711
-0.883
1.330
-1.078
2.448
-3.577
1.422
-3.744
1.985
0.722
1.650
4.346
0.462
-0.950
-0.876
1.688
0.202
-1.825
-0.359
-1.264
-0.515
-3.829
-4.172
-2.342
0.924
-2.600
-1.762
2.073
2.141
1.004
1.833
2.828
0.321
-2.959
-0.991
3.298
-1.064
-4.967
-3.516
0.748
0.397
0.660
5.019
1.192
0.248
2.031
0.693
-1.358
0.724
1.590
0.940
1.273
0.538
-0.736
0.251
1.314
-1.765
0.881
ns
0.165
-0.035
1.202
-0.179
-1.772
-0.697
0.228
1.312
1.073
-1.686
0.238
2.051
-2.518
0.040
-2.491
0.876
-2.584
0.444
-2.851
-3.276
-2.387
0.117
-2.562
1.527
1.213
-0.154
0.216
-0.303
2.459
-2.917
1.653
2.103
0.790
-1.561
-3.248
0.721
1.607
-1.889
8.45E-01
6.87E-02
1.66E-01
1.49E-04
9.66E-01
2.76E-04
3.42E-02
8.90E-01
3.54E-01
6.66E-01
5.80E-01
4.12E-01
1.48E-01
7.83E-02
1.28E-06
5.31E-01
1.47E-01
4.90E-02
2.54E-05
7.08E-09
9.92E-01
1.81E-01
9.23E-02
7.57E-05
6.83E-01
2.13E-04
3.92E-01
5.36E-01
4.07E-01
3.15E-02
2.28E-01
2.75E-01
2.33E-06
1.94E-01
2.92E-02
4.22E-06
4.22E-01
2.18E-02
1.46E-02
3.80E-01
4.15E-03
2.35E-01
8.52E-01
2.77E-01
9.17E-01
3.70E-01
5.60E-02
1.97E-01
2.96E-08
6.65E-01
1.02E-02
6.17E-01
9.39E-01
4.77E-01
3.77E-01
1.84E-01
2.81E-01
1.44E-02
3.48E-04
1.55E-01
1.81E-04
4.71E-02
4.70E-01
9.90E-02
1.39E-05
6.44E-01
3.42E-01
3.81E-01
9.13E-02
8.40E-01
6.80E-02
7.20E-01
2.06E-01
6.07E-01
1.29E-04
3.02E-05
1.92E-02
3.55E-01
9.33E-03
7.81E-02
3.82E-02
3.23E-02
3.15E-01
6.69E-02
4.68E-03
7.49E-01
3.08E-03
3.22E-01
9.72E-04
2.88E-01
6.80E-07
4.38E-04
4.54E-01
6.92E-01
5.09E-01
5.19E-07
2.33E-01
8.04E-01
4.23E-02
4.89E-01
1.75E-01
4.69E-01
1.12E-01
3.47E-01
2.03E-01
5.91E-01
4.62E-01
8.02E-01
1.89E-01
7.75E-02
3.78E-01
ns
8.69E-01
9.72E-01
2.29E-01
8.58E-01
7.64E-02
4.86E-01
8.20E-01
1.90E-01
2.83E-01
9.18E-02
8.12E-01
4.03E-02
1.18E-02
9.68E-01
1.28E-02
3.81E-01
9.78E-03
6.57E-01
4.35E-03
1.05E-03
1.70E-02
9.07E-01
1.04E-02
1.27E-01
2.25E-01
8.77E-01
8.29E-01
7.62E-01
1.39E-02
3.54E-03
9.83E-02
3.55E-02
4.30E-01
1.19E-01
1.16E-03
4.71E-01
1.08E-01
5.89E-02
?
?
+
+
+
+
+
+
+
+
+
+
?
+
?
+
?
+
?
+
?
+
+
+
+
+
+
+
+
+
?
+
?
+
+
+
+
+
+
+
?
+
?
+
+
+
+
+
+
+
+
+
+
+
?
?
+
+
+
?
+
+
+
+
+
?
+
+
+
?
+
+
+
+
+
+
+
+
?
+
+
+
?
-
0
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
0
869
0
869
869
869
869
869
869
869
869
0
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
0
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
0
869
869
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
0
869
ns
ns
0.000
0.001
0.000
0.001
-0.001
0.000
0.002
0.001
0.000
-0.013
-0.009
0.000
0.004
0.001
-0.005
0.000
0.001
-0.001
-0.004
-0.003
-0.003
0.005
ns
0.002
-0.003
-0.004
-0.004
ns
0.001
ns
0.000
-0.001
0.000
0.000
0.000
-0.008
0.001
-0.006
ns
0.002
-0.001
-0.001
ns
0.004
0.001
0.005
0.001
0.003
0.001
0.000
0.000
0.002
0.000
0.002
-0.001
ns
0.003
ns
0.001
-0.001
-0.012
0.004
-0.001
-0.001
0.002
-0.012
0.001
-0.001
0.006
-0.002
-0.006
-0.002
0.003
-0.005
-0.002
-0.004
-0.004
0.000
ns
-0.001
-0.008
0.004
-0.002
ns
0.001
-0.001
-0.005
0.000
0.003
-0.001
0.000
0.001
0.000
0.003
0.000
0.007
0.000
0.001
0.001
-0.004
0.003
-0.008
ns
ns
0.001
0.000
0.000
-0.001
-0.001
ns
0.000
0.000
0.002
0.002
0.000
0.002
0.005
0.002
ns
0.008
0.003
-0.004
-0.001
0.002
-0.001
ns
0.000
0.004
0.002
0.003
-0.002
0.002
-0.004
0.000
0.001
-0.003
0.005
-0.006
-0.002
-0.003
-0.001
0.002
ns
0.005
0.006
0.002
ns
-0.003
ns
ns
0.001
0.001
0.001
0.001
0.000
0.001
0.001
0.001
0.001
0.003
0.002
0.000
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.002
0.001
ns
0.001
0.001
0.002
0.004
ns
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.003
0.001
0.003
ns
0.001
0.001
0.003
ns
0.001
0.001
0.003
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
ns
0.001
0.001
0.003
0.002
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.000
0.002
0.002
0.001
ns
0.001
0.002
0.001
0.001
ns
0.001
0.003
0.003
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.000
0.003
0.001
0.001
0.001
0.001
0.001
0.003
ns
ns
0.001
0.004
0.001
0.001
0.002
ns
0.001
0.002
0.002
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.002
0.001
0.005
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
ns
0.001
ns
ns
5.36E-01
3.74E-01
8.84E-01
2.92E-01
1.88E-01
9.63E-01
6.17E-02
4.74E-01
7.53E-01
1.76E-04
1.67E-04
9.75E-01
3.55E-03
2.73E-01
1.72E-05
6.04E-01
1.19E-01
6.37E-03
1.49E-03
7.04E-02
3.23E-02
5.49E-04
ns
5.36E-02
9.87E-03
3.21E-02
2.80E-01
ns
2.99E-01
ns
9.17E-01
5.17E-01
6.08E-01
5.64E-01
7.75E-01
9.64E-03
1.05E-01
2.88E-02
ns
1.03E-01
3.53E-01
7.04E-01
ns
4.36E-04
1.81E-01
3.58E-02
2.52E-01
2.13E-04
4.61E-01
7.87E-01
7.15E-01
2.01E-01
9.75E-01
1.09E-03
4.57E-01
ns
3.26E-02
ns
5.64E-01
3.40E-01
5.35E-04
2.46E-02
5.66E-02
2.55E-01
2.76E-03
5.53E-05
1.41E-01
3.36E-01
4.09E-07
1.58E-01
4.82E-02
4.43E-03
1.64E-02
6.69E-05
2.05E-04
7.78E-03
9.21E-02
8.35E-01
ns
4.69E-01
5.74E-07
2.64E-04
1.33E-01
ns
2.75E-01
5.56E-01
6.88E-02
9.15E-01
4.77E-03
3.68E-01
8.94E-01
4.23E-01
8.86E-01
7.97E-03
4.14E-01
1.02E-02
9.32E-01
4.75E-01
4.25E-01
9.16E-03
1.43E-02
6.13E-03
ns
ns
3.80E-01
9.38E-01
8.35E-01
3.53E-01
5.55E-01
ns
6.29E-01
8.82E-01
1.72E-01
8.30E-03
8.86E-01
6.31E-02
3.29E-06
6.32E-02
ns
8.53E-10
5.49E-04
1.47E-05
4.15E-01
1.12E-01
5.98E-01
ns
9.14E-01
3.45E-05
1.75E-02
1.60E-03
2.62E-01
1.31E-02
2.81E-03
9.47E-01
5.22E-01
8.25E-02
9.88E-06
2.66E-01
2.01E-01
1.60E-03
3.21E-01
5.23E-02
ns
1.56E-04
1.99E-05
3.65E-02
ns
9.04E-05
?
?
?
?
?
?
?
?
?
?
?
?
+
?
+
?
?
?
?
?
+
+
?
?
+
+
?
+
?
+
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
+
?
+
?
?
?
+
?
?
?
?
+
?
?
?
+
?
+
?
?
?
?
?
?
?
?
+
+
?
?
?
+
+
?
?
?
?
+
+
?
+
+
?
?
?
?
?
?
?
?
+
?
?
?
?
+
?
?
?
+
?
?
?
?
?
?
?
-
1244
0
0
0
0
0
0
0
1244
1244
0
0
0
1244
0
1244
0
1244
0
1244
1244
0
0
1244
0
0
0
1244
1244
0
0
1244
1244
1244
0
1244
1244
0
1244
1244
0
0
0
1244
0
0
0
1244
0
1244
0
1244
1244
0
0
0
0
0
1244
0
1244
0
1244
1244
0
1244
1244
0
1244
0
0
1244
0
0
1244
1244
1244
0
1244
0
1244
0
1244
0
0
1244
1244
0
1244
0
0
0
0
0
0
0
0
1244
1244
0
0
0
1244
1244
1244
0
0
0
0
1244
1244
0
1244
1244
1244
0
0
0
0
0
0
0
0
1244
1244
0
1244
0
1244
1244
1244
1244
0
1244
0
1244
0
1244
0
0
1244
0
0
0
1244
0
0
0
0
1244
-0.001
ns
ns
ns
ns
ns
ns
ns
-0.001
-0.001
ns
ns
ns
-0.002
ns
-0.002
ns
0.001
ns
-0.001
0.003
ns
ns
-0.001
ns
ns
ns
0.004
0.000
ns
ns
0.001
-0.002
0.005
ns
0.005
-0.002
ns
0.002
-0.002
ns
ns
ns
0.001
ns
ns
ns
-0.007
ns
-0.002
ns
-0.004
-0.002
ns
ns
ns
ns
ns
-0.001
ns
-0.002
ns
-0.002
0.003
ns
-0.001
0.000
ns
-0.002
ns
ns
0.002
ns
ns
0.000
-0.002
-0.001
ns
-0.003
ns
0.000
ns
-0.002
ns
ns
0.001
-0.001
ns
0.001
ns
ns
ns
ns
ns
ns
ns
ns
0.002
0.001
ns
ns
ns
0.002
-0.003
0.001
ns
ns
ns
ns
0.003
0.010
ns
0.001
0.002
-0.002
ns
ns
ns
ns
ns
ns
ns
ns
0.001
-0.001
ns
-0.001
ns
-0.002
0.000
-0.001
-0.001
ns
-0.001
ns
0.002
ns
-0.001
ns
ns
0.003
ns
ns
ns
0.000
ns
ns
ns
ns
-0.002
0.000
ns
ns
ns
ns
ns
ns
ns
0.000
0.001
ns
ns
ns
0.000
ns
0.000
ns
0.000
ns
0.001
0.000
ns
ns
0.000
ns
ns
ns
0.000
0.001
ns
ns
0.000
0.000
0.001
ns
0.001
0.001
ns
0.000
0.000
ns
ns
ns
0.000
ns
ns
ns
0.001
ns
0.000
ns
0.000
0.000
ns
ns
ns
ns
ns
0.000
ns
0.000
ns
0.000
0.000
ns
0.000
0.000
ns
0.000
ns
ns
0.000
ns
ns
0.000
0.001
0.001
ns
0.000
ns
0.000
ns
0.001
ns
ns
0.000
0.000
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
0.001
0.001
ns
ns
ns
0.000
0.000
0.000
ns
ns
ns
ns
0.001
0.001
ns
0.000
0.001
0.001
ns
ns
ns
ns
ns
ns
ns
ns
0.000
0.000
ns
0.000
ns
0.000
0.000
0.000
0.000
ns
0.000
ns
0.001
ns
0.000
ns
ns
0.000
ns
ns
ns
0.000
ns
ns
ns
ns
0.000
5.67E-07
ns
ns
ns
ns
ns
ns
ns
1.49E-04
6.42E-02
ns
ns
ns
2.80E-08
ns
1.87E-13
ns
4.66E-04
ns
1.86E-02
4.01E-17
ns
ns
2.12E-05
ns
ns
ns
2.91E-24
6.44E-01
ns
ns
1.26E-03
1.31E-06
8.33E-19
ns
3.01E-09
4.64E-02
ns
1.90E-07
7.00E-12
ns
ns
ns
9.18E-11
ns
ns
ns
2.68E-14
ns
5.48E-09
ns
7.71E-18
1.46E-08
ns
ns
ns
ns
ns
2.73E-05
ns
2.21E-11
ns
4.97E-05
1.19E-15
ns
4.44E-04
1.79E-01
ns
2.49E-08
ns
ns
8.19E-07
ns
ns
4.31E-02
2.44E-03
4.50E-01
ns
1.74E-08
ns
4.85E-01
ns
2.88E-04
ns
ns
3.49E-03
7.49E-04
ns
2.06E-02
ns
ns
ns
ns
ns
ns
ns
ns
2.33E-06
1.98E-01
ns
ns
ns
6.21E-07
4.43E-10
3.76E-05
ns
ns
ns
ns
1.28E-06
2.19E-24
ns
1.15E-01
9.24E-06
1.59E-02
ns
ns
ns
ns
ns
ns
ns
ns
2.42E-06
1.10E-01
ns
1.36E-05
ns
2.09E-07
1.67E-01
2.24E-08
2.34E-06
ns
1.02E-02
ns
4.75E-03
ns
5.59E-02
ns
ns
6.72E-25
ns
ns
ns
2.24E-01
ns
ns
ns
ns
9.45E-14
-?
+?
++
??
++
-+
---+
+-+
-+
----?
-++
-++
++
-+--?
-+
-++
+--+
++
-+
++
+?
++
--+
+-+
-?
-+
-+
+?
++
+-----+
-+
-+
++
--+
-+
++
-+
+?
-0+
-++
++
-?
++
-+
+-?
-+
++
-+
++
--+
-+
+-+
-+
-?
-+
+++
++
+-+
-++
-+
---+
--?
++
+++
++-++
+--?
---+
++
++
++
-?
++
+-+
++
-+
++
-+
--+
+-++
-+
+-+?
-++
--+
---+
-+
---+++
-+
+?
++
+-?
-+
-+
-?
-+
134
134
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
134
362
362
134
362
-1.080
0.458
1.336
0.000
2.479
-0.295
-3.159
-2.371
-0.576
-1.221
-0.668
-0.516
-1.708
-2.050
-1.754
-0.681
-4.124
1.793
-4.022
1.147
1.333
-1.984
-0.338
-2.132
-1.392
-1.599
-1.357
2.638
-0.639
-2.101
0.609
0.805
-0.498
0.914
0.064
0.937
-1.462
0.012
-0.177
-0.069
-1.440
-0.198
-0.717
0.178
1.980
-0.084
-2.110
-4.743
-2.301
-1.051
-0.746
-0.299
-0.553
2.760
-1.373
-0.537
-0.662
1.573
-0.358
0.094
-2.420
0.562
-2.628
0.932
1.462
-1.834
0.873
0.057
-0.412
-1.992
-1.000
1.820
-0.376
0.888
-0.660
-0.562
0.332
-1.338
-1.331
0.444
-0.893
0.257
-1.809
0.230
3.098
-0.717
0.208
-2.074
0.836
0.997
-3.858
-2.636
-0.585
-1.015
-0.910
0.953
-1.096
1.573
-0.458
-1.068
-1.296
1.132
-0.528
-2.344
-0.824
-2.175
-1.865
0.791
1.543
0.724
2.105
-1.542
0.489
-0.854
0.510
0.594
-0.098
3.394
-2.436
-2.576
1.729
-0.412
-2.187
2.542
-0.048
-0.055
-1.886
0.045
-2.773
1.068
-1.147
-1.088
-2.041
-1.050
0.337
0.694
-2.776
-2.325
-3.892
-2.800
0.642
-0.295
0.068
0.238
-0.173
-2.125
-0.594
1.026
-0.767
-0.469
2.80E-01
6.47E-01
1.81E-01
1.00E+00
1.32E-02
7.68E-01
1.58E-03
1.77E-02
5.65E-01
2.22E-01
5.04E-01
6.06E-01
8.77E-02
4.04E-02
7.94E-02
4.96E-01
3.73E-05
7.30E-02
5.76E-05
2.51E-01
1.82E-01
4.73E-02
7.36E-01
3.30E-02
1.64E-01
1.10E-01
1.75E-01
8.33E-03
5.23E-01
3.56E-02
5.42E-01
4.21E-01
6.18E-01
3.61E-01
9.49E-01
3.49E-01
1.44E-01
9.90E-01
8.59E-01
9.45E-01
1.50E-01
8.43E-01
4.73E-01
8.59E-01
4.78E-02
9.33E-01
3.49E-02
2.11E-06
2.14E-02
2.93E-01
4.55E-01
7.65E-01
5.80E-01
5.77E-03
1.70E-01
5.92E-01
5.08E-01
1.16E-01
7.20E-01
9.25E-01
1.55E-02
5.74E-01
8.59E-03
3.52E-01
1.44E-01
6.67E-02
3.83E-01
9.54E-01
6.80E-01
4.64E-02
3.17E-01
6.87E-02
7.07E-01
3.74E-01
5.09E-01
5.74E-01
7.40E-01
1.81E-01
1.83E-01
6.57E-01
3.72E-01
7.97E-01
7.05E-02
8.18E-01
1.95E-03
4.73E-01
8.35E-01
3.81E-02
4.03E-01
3.19E-01
1.14E-04
8.38E-03
5.59E-01
3.10E-01
3.63E-01
3.41E-01
2.73E-01
1.16E-01
6.47E-01
2.86E-01
1.95E-01
2.58E-01
5.98E-01
1.91E-02
4.10E-01
2.97E-02
6.22E-02
4.29E-01
1.23E-01
4.69E-01
3.53E-02
1.23E-01
6.25E-01
3.93E-01
6.10E-01
5.52E-01
9.22E-01
6.88E-04
1.49E-02
1.00E-02
8.39E-02
6.80E-01
2.87E-02
1.10E-02
9.62E-01
9.57E-01
5.93E-02
9.64E-01
5.55E-03
2.85E-01
2.52E-01
2.77E-01
4.13E-02
2.94E-01
7.36E-01
4.87E-01
5.51E-03
2.01E-02
9.94E-05
5.11E-03
5.21E-01
7.68E-01
9.46E-01
8.12E-01
8.62E-01
3.36E-02
5.53E-01
3.05E-01
4.43E-01
6.39E-01
45421
23725
37214
67967
38294
45323
45266
4109
45244
20246
52246
55629
4816
62886
63666
49446
66984
41653
53348
29996
29160
1108
38171
50267
58624
43819
51745
60136
7455
20448
42546
8445
54318
59274
48961
42667
24349
56590
9716
33786
32149
50125
455
47756
67716
27484
55464
9378
42852
16567
15900
28196
9997
1644
63235
47925
41340
19410
46418
50612
10901
52394
41712
58392
21714
25737
31827
42970
5695
49765
23281
58118
63689
1897
26978
47904
1922
10534
27775
42202
32036
61335
426
67791
64509
5852
39064
49562
58921
66838
10638
42673
4853
62670
61065
16054
31661
11560
58631
64778
1950
64139
5653
32866
20682
20744
62631
50269
53171
65149
18756
63039
9621
30132
47890
62447
25296
63269
32065
3467
64885
2282
3055
47855
1677
43041
6728
50905
35693
61696
11007
23973
46301
15195
42265
43425
10509
17745
30113
23133
53045
10594
28342
62229
15111
18693
22070
56210
62881
57182
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
113246
5464
51225
6207
118932
6125
84991
26751
965
10235
6723
26240
152137
6920
79992
1573
202134
6036
64400
79053
9315
4691
27079
3112
8460
201633
253782
23560
4863
23108
6175
9332
84311
3033
719
6732
10184
8672
3150
1479
1028
114836
64231
5898
57711
92
55062
23218
7570
5900
7378
54433
56985
57696
9790
51669
57136
241
5271
4234
118429
81544
90075
84946
137797
1318
2593
11326
23710
57122
7203
1019
147184
84824
6919
967
9678
158295
16
79731
11186
55900
1776
1975
116447
10591
64062
353189
6431
5269
953
639
1824
22887
55506
1870
7486
54517
90488
10418
5934
79180
55846
9710
55701
29997
9540
25923
400916
5911
57819
9166
1521
283
8644
11000
23318
132
80746
2882
10575
84273
6310
51602
23304
6720
1974
83939
23022
4242
10577
7124
146857
4967
80008
321
8676
26056
1514
26135
7597
84441
191
4259
28984
199675
51018
88455
388524
2581
C12orf57
PPA1
ABI3
RPS13
ANKRD22
RPL5
RBM17
SH3YL1
CD58
RASGRP2
SRM
FAM50B
CCDC50
TCEA3
AGPAT4-IT1
CYP2J2
FAM153B
RNASE2
AKTIP
ALG8
NREP
NCL
RPUSD2
HLA-DOB
TPST1
TIGIT
CERS6
GTPBP4
NPAT
RAP1GAP2
RPLP0
CD163
MRPL45
HADH
C3AR1
SRPK1
LHFPL2
EIF4G3
HMGN1
CSTF3
CDKN1C
SLAMF6
MS4A6A
RALA
ZNF529
ACVR2A
WIPI1
NBEAL2
ZNF22
RALGDS
UPP1
GAR1
ADPRM
DDX55
BMS1
TMEM66
APMAP
ALOX5AP
SERPINB8
METTL1
ANTXR2
GDPD5
ZNF30
LTV1
LYPD2
SLC31A2
GAMT
VSIG4
GABARAPL1
NUP107
CCT3
CDK4
TMEM99
FCRLA
TCEA2
CD63
PHF14
MGC24103
AARS
NARS2
RASSF1
ZNF302
DNASE1L3
EIF4B
TOP1MT
C6orf108
RBM26
SLCO4C1
SRSF6
SERPINB6
ENTPD1
PRDM1
DSC2
FOXJ3
H2AFY2
E2F2
WRN
PUS7
C12orf23
SPON1
RBL2
EFHD2
ITFG2
KIAA0355
ARHGEF40
GLTSCR2
TP53I3
ATL3
CHCHD10
RAP2A
LSM2
EBAG9
CTSW
ANG
AKR1C3
SLC27A3
ZCCHC11
ADK
TSEN2
GPX7
CCT4
NOA1
ATXN1
NOP58
UBR2
SREBF1
EIF4A2
EIF2A
PALLD
MFNG
NPC2
TNF
SLFN13
OGDH
TMEM156
APBA2
STX11
RAB11FIP5
CTSL1
SERBP1
ZBTB25
MAML2
AHCY
MGST3
RGCC
C19orf59
RRP15
ANKRD13A
RPSAP58
GALC
----------++++++
-----++++++
---------------++++++
----------+
---------------++++++
----------++++++
------------+------------------+++++
++++++
---?-------+-+-++++++
------+++++
---+------++++++
+++-++
++++++
++-+++
--------?-++-+++
++-+++
++++++
---+------+++?++
++++++
++++++
-----++-+++
++++++
----------------------+--++++++
++++++
++++++
-----++++++
++-+++
----------++-+++
++++++
-----++++++
++++++
------------------------------++++++
----+++++++
----------++-+++
------------------------------++++-+
-----++-+++
++++++
++++++
++++++
----------++-++-------------------------++++++
----------++++++
-----++++++
+-++++
-----++++++
----------++-+++
++++++
++-+++
++++++
-------------?----------------+
+-+-++
-----++++++
--+--+
----------++++++
-----++++++
++-+++
++++++
++-+++
----------++++++
++-+++
++-+++
---?--------------+-+
++++++
-----++++++
-----++++++
-----++++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-8.090
-8.126
9.047
-8.268
9.027
-8.425
-9.347
-8.183
7.646
-7.579
-6.730
-8.660
-6.742
-9.059
7.811
-9.597
-9.844
10.068
-8.915
-9.204
-5.383
-8.051
-7.728
-7.920
8.293
7.926
-6.352
-8.535
-7.338
7.648
-7.938
8.649
-7.782
-8.224
9.917
6.577
10.162
8.078
-7.478
-6.665
7.527
7.581
10.094
-8.749
-8.774
5.437
9.911
7.626
-8.274
7.733
7.531
-7.761
-9.344
-8.892
-8.645
-8.544
8.466
9.430
8.192
-6.573
6.649
7.629
-9.575
-7.283
6.259
8.343
-8.046
8.887
7.763
-7.703
-7.646
-6.470
-8.203
-7.099
-6.203
9.247
-6.920
7.693
-8.002
-8.208
8.596
-8.365
-8.102
-8.539
-7.552
-7.980
-7.986
9.776
-8.212
7.029
7.772
7.200
7.526
-8.548
-7.654
5.197
-8.204
-9.375
-8.251
-9.021
-8.266
8.422
-7.303
-9.817
7.736
-8.626
8.996
6.477
-7.693
7.637
-6.333
-8.321
8.435
9.575
7.032
8.379
-7.152
-8.634
-9.203
-8.100
-7.897
-7.625
7.180
-7.055
5.373
-5.137
-8.599
-7.890
8.495
-7.435
9.297
4.987
6.358
6.712
-7.328
-8.634
8.843
8.530
6.128
-8.272
-9.157
-9.080
-5.862
8.851
-9.199
8.406
-8.141
7.824
-7.797
6.130
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
5.96E-16
4.42E-16
1.47E-19
1.36E-16
1.76E-19
3.61E-17
9.05E-21
2.77E-16
2.07E-14
3.49E-14
1.70E-11
4.72E-18
1.56E-11
1.31E-19
5.66E-15
8.24E-22
7.24E-23
7.62E-24
4.89E-19
3.46E-20
7.33E-08
8.19E-16
1.09E-14
2.38E-15
1.11E-16
2.27E-15
2.12E-10
1.40E-17
2.17E-13
2.04E-14
2.06E-15
5.22E-18
7.13E-15
1.96E-16
3.52E-23
4.79E-11
2.94E-24
6.59E-16
7.57E-14
2.64E-11
5.21E-14
3.43E-14
5.89E-24
2.15E-18
1.72E-18
5.43E-08
3.72E-23
2.42E-14
1.29E-16
1.05E-14
5.02E-14
8.45E-15
9.23E-21
5.98E-19
5.38E-18
1.30E-17
2.55E-17
4.09E-21
2.56E-16
4.93E-11
2.96E-11
2.37E-14
1.02E-21
3.25E-13
3.88E-10
7.25E-17
8.55E-16
6.28E-19
8.31E-15
1.33E-14
2.08E-14
9.77E-11
2.34E-16
1.25E-12
5.54E-10
2.31E-20
4.51E-12
1.43E-14
1.22E-15
2.25E-16
8.24E-18
5.99E-17
5.39E-16
1.35E-17
4.30E-14
1.46E-15
1.40E-15
1.43E-22
2.18E-16
2.08E-12
7.75E-15
6.03E-13
5.23E-14
1.25E-17
1.96E-14
2.02E-07
2.32E-16
6.90E-21
1.57E-16
1.86E-19
1.39E-16
3.70E-17
2.81E-13
9.49E-23
1.03E-14
6.38E-18
2.34E-19
9.35E-11
1.44E-14
2.22E-14
2.41E-10
8.73E-17
3.32E-17
1.02E-21
2.04E-12
5.34E-17
8.53E-13
5.91E-18
3.49E-20
5.51E-16
2.87E-15
2.45E-14
6.99E-13
1.73E-12
7.73E-08
2.80E-07
8.05E-18
3.02E-15
1.98E-17
1.05E-13
1.45E-20
6.14E-07
2.04E-10
1.92E-11
2.33E-13
5.94E-18
9.33E-19
1.46E-17
8.91E-10
1.31E-16
5.33E-20
1.08E-19
4.58E-09
8.66E-19
3.60E-20
4.24E-17
3.92E-16
5.11E-15
6.34E-15
8.81E-10
--------------++++++++
-------+++-++++
---------------------+++-+-++
-----+---------------------------+-++++++++
-----??+----+-+++++-++
-----+----++----+---------+-----------+---++++++-+
++-+--++
-----+---------+---+-++++++++
-+-----++++++++
--------------+++++-++
+++-++++
++++++++
-++-++++
--------------++++++++
-+-+++++
+++-+-++
--------------+++++-?+
-++-++-+
+-++++++
--+----++-+++++
++++++++
-----------------------------------+++-++-+
++++++++
++++++++
-------++++-+++
++++++++
--------------++++++++
++++++-+
---+--++++++-++
++++++++
-------------------------------+------+---++++++++
-+-----+++-++++
----------+---++++++++
--------+---??------------+----------------++--+-+
-------+++++-++
+++-++-+
++++++++
+++++-++
--------------++++-+++
------------+----+-??---+--+-------+++-++++
--------------+
++++++++
-------++++++++
++++++++
----++-+++-++++
----+---------++++++++
+-++++++
++++++++
++++++++
-----+----++--------------+---------------+--+++++
-------++++++++
-----+---------------++++++++
-------++++++++
++++++++
++++++++
+-++++++
-+---?-------?++++++++
+++++++++++-+++
------------+-------+----+--++++++++
---+---+
++++++++
-------+-++++++
-------+++++-++
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
7782
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
-7.96
-7.92
7.04
-7.76
7.01
-7.58
-6.71
-7.81
8.32
-8.38
-9.15
-7.31
-9.12
-6.92
8.10
-6.19
-6.14
5.90
-7.00
-6.72
-10.34
-7.80
-8.11
-7.92
7.55
7.89
-9.29
-7.28
-8.39
8.09
-7.79
7.08
-7.89
-7.47
5.84
9.02
5.59
7.58
-8.12
-8.84
8.06
8.01
5.62
-6.89
-6.87
10.11
5.76
7.93
-7.31
7.82
8.01
-7.77
-6.27
-6.68
-6.91
-7.00
7.07
6.15
7.32
-8.85
8.78
7.81
-5.95
-8.12
9.08
7.09
-7.34
6.54
7.60
-7.64
-7.69
-8.81
-7.14
-8.18
-9.02
6.12
-8.33
7.59
-7.26
-7.05
6.68
-6.89
-7.09
-6.71
-7.65
-7.22
-7.21
5.50
-6.99
8.11
7.40
7.92
7.61
-6.63
-7.47
9.78
-6.92
-5.79
-6.77
-6.12
-6.83
6.68
-7.74
-5.32
7.29
-6.43
6.07
8.45
-7.28
7.32
-8.55
-6.64
6.51
5.42
7.84
6.55
-7.71
-6.29
-5.87
-6.79
-6.98
-7.20
7.60
-7.69
9.27
-9.48
-6.18
-6.84
6.25
-7.25
5.42
9.51
8.20
7.86
-7.25
-5.86
5.78
6.08
8.37
-6.39
-5.47
-5.53
-8.59
5.74
-5.40
6.15
-6.39
6.69
-6.72
8.30
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.75E-15
2.48E-15
1.96E-12
8.75E-15
2.32E-12
3.34E-14
1.99E-11
5.76E-15
9.01E-17
5.51E-17
5.72E-20
2.76E-13
7.30E-20
4.69E-12
5.75E-16
6.09E-10
8.18E-10
3.54E-09
2.56E-12
1.82E-11
4.58E-25
6.18E-15
5.21E-16
2.37E-15
4.40E-14
3.15E-15
1.53E-20
3.41E-13
4.79E-17
5.93E-16
6.61E-15
1.45E-12
2.94E-15
7.90E-14
5.18E-09
1.95E-19
2.23E-08
3.60E-14
4.67E-16
9.60E-19
7.65E-16
1.17E-15
1.96E-08
5.42E-12
6.62E-12
5.13E-24
8.44E-09
2.21E-15
2.75E-13
5.46E-15
1.19E-15
7.58E-15
3.72E-10
2.41E-11
4.92E-12
2.56E-12
1.55E-12
7.97E-10
2.58E-13
8.66E-19
1.70E-18
5.93E-15
2.67E-09
4.53E-16
1.12E-19
1.32E-12
2.14E-13
6.38E-11
2.95E-14
2.15E-14
1.46E-14
1.28E-18
9.59E-13
2.74E-16
1.86E-19
9.25E-10
7.95E-17
3.33E-14
3.95E-13
1.81E-12
2.44E-11
5.53E-12
1.39E-12
1.93E-11
2.00E-14
5.12E-13
5.61E-13
3.78E-08
2.84E-12
5.18E-16
1.36E-13
2.30E-15
2.76E-14
3.47E-11
7.76E-14
1.36E-22
4.66E-12
7.07E-09
1.25E-11
9.41E-10
8.43E-12
2.48E-11
1.01E-14
1.04E-07
3.01E-13
1.30E-10
1.32E-09
2.84E-17
3.47E-13
2.51E-13
1.29E-17
3.25E-11
7.32E-11
5.98E-08
4.53E-15
5.82E-11
1.25E-14
3.09E-10
4.47E-09
1.16E-11
3.05E-12
5.83E-13
2.89E-14
1.51E-14
1.82E-20
2.45E-21
6.59E-10
8.08E-12
4.06E-10
4.19E-13
6.01E-08
1.84E-21
2.37E-16
3.77E-15
4.23E-13
4.62E-09
7.38E-09
1.21E-09
5.99E-17
1.63E-10
4.45E-08
3.21E-08
8.84E-18
9.60E-09
6.84E-08
7.88E-10
1.63E-10
2.17E-11
1.85E-11
1.03E-16
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13582
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
12928
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13582
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13582
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15039
13809
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
-11.342
-11.336
11.335
-11.319
11.304
-11.302
-11.302
-11.298
11.296
-11.292
-11.267
-11.262
-11.257
-11.255
11.249
-11.238
-11.236
11.218
-11.217
-11.213
-11.202
-11.201
-11.2
-11.197
11.185
11.176
-11.162
-11.156
-11.138
11.133
-11.116
11.09
-11.083
-11.083
11.068
11.065
11.057
11.056
-11.037
-11.033
11.027
11.027
11.027
-11.026
-11.022
11.013
11.005
11.001
-10.997
10.993
10.991
-10.982
-10.981
-10.969
-10.964
-10.961
10.958
10.953
10.947
-10.943
10.94
10.913
-10.912
-10.906
10.89
10.889
-10.864
10.86
10.857
-10.846
-10.842
-10.841
-10.825
-10.823
-10.811
10.81
-10.806
10.798
-10.774
-10.764
10.763
-10.759
-10.757
-10.749
-10.748
-10.733
-10.728
10.724
-10.721
10.718
10.718
10.704
10.7
-10.692
-10.69
10.668
-10.666
-10.657
-10.654
-10.652
-10.647
10.641
-10.64
-10.622
10.617
-10.602
10.595
10.588
-10.573
10.566
-10.555
-10.543
10.534
10.527
10.526
10.52
-10.516
-10.512
-10.504
-10.499
-10.497
-10.475
10.457
-10.432
10.421
-10.411
-10.402
-10.392
10.385
-10.377
10.334
10.329
10.324
10.323
-10.304
-10.296
10.285
10.284
10.284
-10.278
-10.277
-10.266
-10.262
10.258
-10.251
10.248
-10.243
10.243
-10.241
10.239
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
8.13E-30
8.74E-30
8.82E-30
1.06E-29
1.25E-29
1.28E-29
1.28E-29
1.34E-29
1.37E-29
1.44E-29
1.91E-29
2.01E-29
2.15E-29
2.20E-29
2.35E-29
2.66E-29
2.72E-29
3.31E-29
3.38E-29
3.53E-29
4.00E-29
4.03E-29
4.07E-29
4.21E-29
4.83E-29
5.37E-29
6.28E-29
6.72E-29
8.24E-29
8.63E-29
1.04E-28
1.40E-28
1.52E-28
1.52E-28
1.79E-28
1.85E-28
2.02E-28
2.05E-28
2.54E-28
2.64E-28
2.83E-28
2.84E-28
2.84E-28
2.87E-28
2.98E-28
3.29E-28
3.61E-28
3.78E-28
3.95E-28
4.14E-28
4.22E-28
4.67E-28
4.72E-28
5.41E-28
5.70E-28
5.90E-28
6.11E-28
6.42E-28
6.90E-28
7.18E-28
7.40E-28
9.95E-28
1.01E-27
1.08E-27
1.29E-27
1.30E-27
1.72E-27
1.78E-27
1.84E-27
2.09E-27
2.17E-27
2.21E-27
2.63E-27
2.68E-27
3.05E-27
3.10E-27
3.22E-27
3.51E-27
4.57E-27
5.07E-27
5.15E-27
5.37E-27
5.46E-27
6.01E-27
6.05E-27
7.11E-27
7.54E-27
7.81E-27
8.08E-27
8.34E-27
8.35E-27
9.80E-27
1.01E-26
1.11E-26
1.13E-26
1.44E-26
1.47E-26
1.61E-26
1.67E-26
1.71E-26
1.81E-26
1.92E-26
1.94E-26
2.36E-26
2.50E-26
2.91E-26
3.13E-26
3.37E-26
3.97E-26
4.27E-26
4.81E-26
5.49E-26
6.05E-26
6.49E-26
6.54E-26
6.98E-26
7.26E-26
7.60E-26
8.31E-26
8.73E-26
8.94E-26
1.12E-25
1.36E-25
1.78E-25
1.99E-25
2.22E-25
2.43E-25
2.69E-25
2.90E-25
3.17E-25
4.92E-25
5.20E-25
5.46E-25
5.57E-25
6.73E-25
7.38E-25
8.24E-25
8.28E-25
8.31E-25
8.89E-25
8.95E-25
1.00E-24
1.05E-24
1.08E-24
1.18E-24
1.20E-24
1.27E-24
1.27E-24
1.30E-24
1.33E-24
?
?
+
+
+
?
?
+
+
?
+
+
?
+
+
?
?
?
+
?
?
+
?
?
?
?
?
+
+
?
+
+
?
?
?
+
+
?
?
?
?
+
?
?
+
+
+
?
+
?
+
+
+
?
+
?
?
+
+
?
?
?
+
?
+
?
+
+
+
?
+
?
?
+
?
?
+
+
+
+
?
?
+
+
+
+
+
?
+
?
?
+
?
+
?
+
+
+
?
?
+
?
?
+
?
394
394
0
394
0
394
394
394
0
0
394
394
394
394
0
394
394
0
394
394
394
394
394
0
394
0
394
0
394
0
394
0
394
394
0
394
394
394
0
394
0
0
0
394
394
394
394
0
394
394
394
0
0
0
394
394
394
0
0
0
0
394
394
394
0
394
394
0
394
394
394
394
394
0
394
394
394
0
394
394
394
394
0
394
0
394
394
0
394
394
0
0
0
394
394
0
394
394
0
394
394
394
394
394
0
394
0
0
394
394
394
394
0
0
394
394
394
394
394
0
0
394
394
394
394
394
394
394
394
0
394
0
0
394
0
394
0
394
394
394
0
0
394
394
394
0
0
394
394
0
-0.005
-0.008
ns
-0.005
ns
0.003
0.005
0.001
ns
ns
0.001
-0.002
-0.015
0.004
ns
0.007
0.002
ns
-0.002
0.008
-0.010
-0.002
0.011
ns
-0.007
ns
-0.006
ns
0.015
ns
-0.008
ns
-0.006
0.004
ns
-0.006
0.000
-0.001
ns
-0.002
ns
ns
ns
-0.003
0.009
0.007
0.000
ns
-0.001
0.004
0.019
ns
ns
ns
0.010
-0.007
0.000
ns
ns
ns
ns
-0.009
0.003
-0.001
ns
-0.011
-0.003
ns
0.001
0.008
-0.002
0.001
-0.002
ns
0.010
-0.005
-0.007
ns
0.007
0.007
0.003
-0.002
ns
0.012
ns
-0.002
-0.001
ns
0.013
0.011
ns
ns
ns
0.006
-0.001
ns
0.002
-0.001
ns
-0.009
0.002
-0.008
0.010
0.006
ns
0.013
ns
ns
-0.001
-0.010
-0.003
0.002
ns
ns
0.007
0.015
0.004
-0.007
0.012
ns
ns
-0.005
-0.005
0.004
0.010
0.002
0.001
0.003
-0.003
ns
0.000
ns
ns
0.009
ns
0.005
ns
0.012
0.004
0.003
ns
ns
-0.015
-0.008
0.000
ns
ns
-0.006
0.004
ns
0.003
0.003
ns
0.003
ns
0.003
0.003
0.002
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
0.004
ns
0.003
0.003
0.003
0.003
0.003
ns
0.004
ns
0.004
ns
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.004
0.003
0.003
ns
ns
ns
0.003
0.003
0.004
ns
ns
ns
ns
0.003
0.003
0.004
ns
0.004
0.003
ns
0.003
0.003
0.003
0.004
0.003
ns
0.003
0.004
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
0.004
0.003
ns
0.003
0.003
ns
ns
ns
0.003
0.004
ns
0.003
0.004
ns
0.003
0.003
0.004
0.003
0.003
ns
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.002
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
1.70E-01
1.60E-02
ns
1.09E-01
ns
2.42E-01
1.06E-01
6.88E-01
ns
ns
7.57E-01
6.08E-01
6.61E-06
2.33E-01
ns
1.95E-02
6.05E-01
ns
6.48E-01
1.13E-02
1.51E-03
4.51E-01
4.36E-05
ns
4.45E-02
ns
7.31E-02
ns
2.40E-06
ns
8.10E-03
ns
7.10E-02
2.00E-01
ns
4.48E-02
8.86E-01
8.62E-01
ns
5.64E-01
ns
ns
ns
3.05E-01
8.42E-03
1.64E-02
9.49E-01
ns
7.66E-01
2.29E-01
1.14E-07
ns
ns
ns
8.56E-04
2.49E-02
8.97E-01
ns
ns
ns
ns
6.34E-03
3.25E-01
7.58E-01
ns
1.61E-03
4.12E-01
ns
7.98E-01
2.02E-02
4.56E-01
7.07E-01
4.83E-01
ns
7.39E-04
1.30E-01
4.32E-02
ns
3.66E-02
3.02E-02
3.27E-01
4.93E-01
ns
4.68E-04
ns
5.16E-01
6.35E-01
ns
1.07E-06
7.82E-04
ns
ns
ns
7.79E-02
7.58E-01
ns
4.83E-01
6.98E-01
ns
3.50E-03
6.06E-01
3.11E-02
1.74E-03
6.47E-02
ns
1.62E-04
ns
ns
6.66E-01
1.89E-03
3.82E-01
6.24E-01
ns
ns
3.02E-02
1.49E-05
2.48E-01
1.94E-02
2.68E-04
ns
ns
1.50E-01
4.38E-02
1.70E-01
2.05E-03
5.20E-01
7.27E-01
4.30E-01
3.01E-01
ns
8.90E-01
ns
ns
9.42E-03
ns
1.15E-01
ns
2.25E-04
2.24E-01
4.17E-01
ns
ns
7.98E-07
1.27E-02
9.17E-01
ns
ns
7.96E-02
1.86E-01
ns
?
+
?
+
+
+
?
?
+
?
+
?
+
+
?
+
?
?
?
?
?
?
+
?
+
?
?
?
+
+
?
+
+
+
?
?
?
+
?
?
?
+
+
?
+
+
?
+
+
+
+
?
+
+
?
+
+
+
?
+
+
+
?
?
+
+
?
?
?
+
?
+
+
?
+
+
+
+
+
?
+
?
?
+
+
?
?
+
+
+
+
?
?
+
+
+
+
?
+
?
?
+
?
+
?
+
+
?
?
+
?
?
+
+
?
394
394
0
394
0
394
394
394
0
0
394
394
394
394
0
394
394
0
394
394
394
394
394
0
394
0
394
0
0
0
394
0
394
394
0
394
394
394
0
394
0
0
0
394
394
394
394
0
394
394
394
0
0
0
394
394
394
394
0
0
0
394
394
394
0
394
394
0
394
394
394
394
394
0
394
394
394
0
394
394
394
394
0
394
394
394
0
0
394
394
0
0
0
394
394
0
394
394
0
394
394
394
394
394
0
394
0
0
394
394
394
394
0
0
394
394
394
394
394
0
0
394
394
394
394
394
394
394
394
0
394
0
0
394
0
394
0
394
394
394
0
0
394
394
394
0
0
394
394
0
-0.008
-0.011
ns
0.002
ns
0.004
0.007
0.000
ns
ns
-0.001
-0.008
-0.010
0.010
ns
0.006
-0.001
ns
-0.003
0.008
-0.018
-0.004
0.013
ns
0.009
ns
-0.011
ns
ns
ns
-0.011
ns
-0.010
-0.001
ns
-0.007
-0.005
0.004
ns
0.004
ns
ns
ns
-0.010
0.014
-0.011
0.007
ns
0.001
0.010
0.020
ns
ns
ns
0.022
-0.014
-0.002
-0.010
ns
ns
ns
0.001
0.002
-0.007
ns
0.009
0.002
ns
-0.003
0.008
0.003
0.009
0.007
ns
0.010
0.005
-0.015
ns
0.023
-0.005
0.004
0.004
ns
0.017
0.011
0.007
ns
ns
0.012
0.013
ns
ns
ns
-0.002
0.002
ns
0.002
0.008
ns
0.002
0.003
0.011
0.016
0.010
ns
0.017
ns
ns
0.003
-0.003
0.008
-0.004
ns
ns
0.008
0.020
0.006
-0.009
0.004
ns
ns
-0.009
-0.007
-0.002
0.011
0.010
0.001
-0.002
0.008
ns
0.012
ns
ns
0.016
ns
0.003
ns
0.003
-0.003
0.002
ns
ns
-0.011
-0.008
0.005
ns
ns
0.010
0.009
ns
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
0.004
ns
ns
ns
0.003
ns
0.003
0.004
ns
0.003
0.003
0.003
ns
0.003
ns
ns
ns
0.003
0.003
0.003
0.004
ns
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
0.004
0.003
ns
0.003
0.004
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.004
0.003
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.002
0.003
0.003
0.003
0.004
0.003
0.003
ns
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
2.87E-02
1.12E-03
ns
4.40E-01
ns
9.69E-02
1.06E-02
9.61E-01
ns
ns
7.88E-01
9.52E-03
2.62E-03
2.60E-03
ns
6.74E-02
6.95E-01
ns
3.54E-01
4.29E-03
2.79E-08
2.27E-01
5.34E-06
ns
8.53E-03
ns
1.38E-03
ns
ns
ns
4.27E-04
ns
1.91E-03
7.93E-01
ns
5.56E-02
1.39E-01
2.14E-01
ns
2.43E-01
ns
ns
ns
1.10E-03
1.10E-04
7.40E-04
3.78E-02
ns
6.79E-01
3.62E-03
9.20E-11
ns
ns
ns
1.12E-12
1.17E-05
5.49E-01
2.13E-03
ns
ns
ns
8.53E-01
4.67E-01
2.87E-02
ns
9.32E-03
4.60E-01
ns
3.80E-01
2.31E-02
2.76E-01
5.31E-03
2.99E-02
ns
1.07E-03
1.50E-01
1.74E-06
ns
8.16E-14
1.63E-01
2.13E-01
1.67E-01
ns
3.81E-07
3.80E-04
3.27E-02
ns
ns
1.67E-05
8.28E-05
ns
ns
ns
4.94E-01
6.28E-01
ns
5.08E-01
1.90E-02
ns
4.67E-01
3.81E-01
7.89E-04
3.46E-09
1.15E-03
ns
3.94E-08
ns
ns
4.01E-01
4.13E-01
1.51E-02
1.87E-01
ns
ns
2.12E-02
4.71E-10
6.31E-02
2.84E-03
2.65E-01
ns
ns
6.97E-03
2.24E-03
6.07E-01
9.84E-04
3.81E-03
8.49E-01
5.32E-01
1.03E-02
ns
6.04E-05
ns
ns
8.15E-07
ns
3.98E-01
ns
4.56E-01
2.65E-01
5.02E-01
ns
ns
3.12E-04
9.35E-03
1.91E-01
ns
ns
1.02E-03
7.02E-03
ns
-+?+
-?+
?-?++
--+
-?-+?
+-?
-+
-+??-+
-?++
-+-+?
??+
--++
+-+
++-?+
+--?++
++
++
-++
+++
-?++?+
++
++
+++
++
--?+
-+
-+
-?
++
?++-?-?+
+++?++
-?+
+--+
-?+
+?
++
-+
?+
-+
?+
-+
++
-??+-++
-+-?
-?+
+?+
++
-+
?++
?+
?+
++
-----+?+
++-+
++?-++
?+
++
++
+-++
++
?+
----+
++-+
-++
+?
?+
515
515
213
515
213
213
515
213
515
515
515
515
213
515
302
515
302
515
515
515
213
213
515
515
213
515
515
515
515
302
213
213
515
515
515
515
515
515
515
515
213
515
515
515
213
515
515
515
515
515
515
515
515
213
515
515
213
515
515
515
515
515
515
515
213
515
515
302
515
213
515
515
515
213
515
213
515
515
515
213
515
515
213
515
515
515
515
213
302
515
515
213
515
213
515
515
515
213
213
515
515
515
515
515
302
515
213
515
213
515
515
213
515
213
213
515
515
515
515
515
515
515
213
515
515
515
515
515
213
515
515
213
515
515
515
515
515
515
213
515
515
515
515
515
515
515
515
515
302
213
-1.824
-0.646
1.221
-2.025
0.942
-1.461
-1.789
-0.878
3.107
-1.559
-0.353
-0.612
-0.938
-0.881
2.432
-0.279
-0.210
-0.422
-1.890
-0.347
-8.276
-0.940
-1.815
-1.569
-1.705
2.745
-4.570
0.294
-1.608
3.171
-2.372
2.240
-1.891
-2.106
3.463
-0.276
-0.625
0.129
-0.331
-1.247
1.305
1.398
-0.373
-1.106
-2.010
2.950
3.717
3.816
-3.412
2.223
-0.586
1.044
-1.343
-2.700
-0.806
-1.246
0.357
4.174
1.201
0.106
2.625
3.092
-1.852
-1.065
1.616
-0.801
-0.132
-0.486
2.287
-2.146
-1.315
0.332
-1.213
-1.007
-0.839
3.099
-0.576
-0.898
-0.038
-2.148
3.649
-1.980
1.293
-0.382
-1.897
-0.107
-0.599
1.526
1.302
2.422
1.415
3.256
0.566
0.224
-0.746
4.154
-1.713
-1.419
-2.681
0.372
-1.773
3.779
-2.574
0.243
-1.359
-1.514
1.863
1.759
1.576
0.971
0.086
-0.684
2.608
1.372
0.358
3.866
-1.406
-1.983
-2.231
-0.902
-1.036
-0.636
3.460
1.120
0.726
-1.457
0.762
-0.550
-0.483
-1.645
0.869
5.157
0.947
2.252
0.135
-3.971
1.978
3.708
0.224
-2.246
-0.562
-1.704
-0.652
0.841
0.057
0.691
-1.109
2.327
1.630
0.714
6.81E-02
5.19E-01
2.22E-01
4.29E-02
3.46E-01
1.44E-01
7.37E-02
3.80E-01
1.89E-03
1.19E-01
7.24E-01
5.40E-01
3.48E-01
3.78E-01
1.50E-02
7.80E-01
8.34E-01
6.73E-01
5.88E-02
7.29E-01
1.27E-16
3.47E-01
6.95E-02
1.17E-01
8.82E-02
6.06E-03
4.88E-06
7.69E-01
1.08E-01
1.52E-03
1.77E-02
2.51E-02
5.86E-02
3.52E-02
5.34E-04
7.83E-01
5.32E-01
8.97E-01
7.40E-01
2.12E-01
1.92E-01
1.62E-01
7.09E-01
2.69E-01
4.44E-02
3.17E-03
2.02E-04
1.36E-04
6.45E-04
2.62E-02
5.58E-01
2.97E-01
1.79E-01
6.94E-03
4.20E-01
2.13E-01
7.21E-01
2.99E-05
2.30E-01
9.16E-01
8.68E-03
1.99E-03
6.41E-02
2.87E-01
1.06E-01
4.23E-01
8.95E-01
6.27E-01
2.22E-02
3.19E-02
1.89E-01
7.40E-01
2.25E-01
3.14E-01
4.02E-01
1.94E-03
5.65E-01
3.69E-01
9.69E-01
3.17E-02
2.64E-04
4.77E-02
1.96E-01
7.02E-01
5.79E-02
9.15E-01
5.49E-01
1.27E-01
1.93E-01
1.54E-02
1.57E-01
1.13E-03
5.72E-01
8.23E-01
4.56E-01
3.27E-05
8.67E-02
1.56E-01
7.34E-03
7.10E-01
7.62E-02
1.58E-04
1.01E-02
8.08E-01
1.74E-01
1.30E-01
6.25E-02
7.86E-02
1.15E-01
3.31E-01
9.31E-01
4.94E-01
9.11E-03
1.70E-01
7.20E-01
1.11E-04
1.60E-01
4.74E-02
2.57E-02
3.67E-01
3.00E-01
5.25E-01
5.41E-04
2.63E-01
4.68E-01
1.45E-01
4.46E-01
5.82E-01
6.29E-01
9.99E-02
3.85E-01
2.51E-07
3.44E-01
2.43E-02
8.93E-01
7.17E-05
4.79E-02
2.09E-04
8.23E-01
2.47E-02
5.74E-01
8.83E-02
5.15E-01
4.00E-01
9.55E-01
4.90E-01
2.67E-01
2.00E-02
1.03E-01
4.75E-01
?
?
?
?
+
?
?
+
+
?
?
?
+
+
?
?
+
+
+
+
?
+
+
?
+
+
+
+
+
?
?
+
+
+
+
?
+
+
+
?
?
?
+
?
+
?
+
+
+
?
+
?
+
?
?
+
+
?
+
?
+
?
+
?
?
+
?
+
+
+
+
+
?
+
+
+
+
?
+
+
+
?
299
299
0
299
0
0
299
0
299
299
299
0
0
299
299
299
299
299
299
299
0
0
299
299
0
299
299
299
299
299
0
0
299
299
299
299
299
299
299
299
0
299
299
299
0
299
299
299
299
299
299
299
299
0
299
299
0
299
299
299
299
299
299
299
0
299
299
299
299
0
299
299
299
0
299
0
299
299
299
0
299
299
0
299
299
299
299
299
299
299
299
0
299
0
299
299
299
0
0
299
299
299
299
299
299
299
0
299
0
299
299
0
299
0
0
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
0
-0.028
-0.027
ns
-0.030
ns
ns
-0.027
ns
0.018
-0.024
-0.011
ns
ns
-0.055
0.007
-0.011
-0.055
0.009
-0.030
-0.007
ns
ns
-0.008
-0.008
ns
0.005
-0.063
-0.002
-0.008
0.033
ns
ns
-0.025
-0.019
0.005
0.005
0.003
0.023
-0.004
-0.013
ns
0.013
0.005
-0.013
ns
0.009
0.009
0.041
-0.034
0.000
0.017
-0.005
-0.034
ns
-0.008
-0.006
ns
0.032
0.004
-0.012
0.020
0.045
-0.014
-0.008
ns
0.007
0.000
-0.002
0.036
ns
-0.015
-0.008
-0.005
ns
-0.010
ns
-0.008
0.002
-0.010
ns
0.028
-0.032
ns
-0.015
-0.036
-0.025
-0.012
0.005
-0.010
0.020
0.003
ns
0.000
ns
-0.026
0.019
-0.012
ns
ns
-0.006
-0.018
0.027
-0.013
-0.017
0.001
-0.003
ns
0.004
ns
0.009
-0.013
ns
0.013
ns
ns
0.032
-0.014
-0.010
-0.009
-0.012
-0.003
-0.018
ns
0.002
0.006
-0.038
0.004
-0.010
0.006
-0.022
0.017
ns
0.005
0.012
0.000
-0.037
0.023
0.007
ns
-0.018
-0.019
-0.006
-0.021
0.007
-0.024
0.017
-0.007
0.006
-0.009
ns
0.006
0.009
ns
0.007
ns
ns
0.007
ns
0.004
0.008
0.005
ns
ns
0.008
0.003
0.002
0.010
0.004
0.006
0.003
ns
ns
0.005
0.005
ns
0.003
0.008
0.005
0.003
0.007
ns
ns
0.005
0.005
0.002
0.005
0.003
0.005
0.008
0.004
ns
0.005
0.006
0.004
ns
0.004
0.003
0.008
0.007
0.005
0.006
0.005
0.006
ns
0.006
0.006
ns
0.009
0.003
0.004
0.006
0.010
0.003
0.005
ns
0.004
0.003
0.003
0.008
ns
0.006
0.004
0.003
ns
0.006
ns
0.003
0.004
0.005
ns
0.006
0.006
ns
0.008
0.006
0.005
0.005
0.002
0.004
0.009
0.003
ns
0.002
ns
0.004
0.006
0.006
ns
ns
0.003
0.008
0.008
0.005
0.005
0.002
0.002
ns
0.004
ns
0.009
0.005
ns
0.009
ns
ns
0.007
0.006
0.004
0.003
0.004
0.002
0.006
ns
0.006
0.004
0.007
0.006
0.006
0.003
0.006
0.006
ns
0.007
0.004
0.002
0.006
0.011
0.005
ns
0.004
0.007
0.002
0.005
0.007
0.009
0.009
0.005
0.005
0.004
ns
6.98E-06
2.80E-03
ns
6.69E-05
ns
ns
6.69E-05
ns
3.24E-05
2.78E-03
1.74E-02
ns
ns
6.83E-12
1.50E-02
9.55E-09
3.66E-07
1.54E-02
3.41E-07
1.94E-02
ns
ns
9.88E-02
1.11E-01
ns
9.99E-02
8.95E-13
6.31E-01
6.02E-03
1.35E-05
ns
ns
4.09E-07
6.40E-04
2.28E-02
2.77E-01
2.00E-01
5.42E-05
5.79E-01
1.28E-03
ns
9.01E-03
3.93E-01
2.60E-03
ns
2.61E-02
3.41E-04
2.55E-06
2.93E-06
9.61E-01
3.08E-03
3.75E-01
9.92E-08
ns
1.96E-01
3.05E-01
ns
4.35E-04
2.01E-01
8.15E-04
6.08E-04
1.46E-05
1.46E-07
8.90E-02
ns
1.10E-01
9.19E-01
5.50E-01
2.71E-05
ns
8.23E-03
2.47E-02
1.08E-01
ns
8.95E-02
ns
1.22E-03
6.33E-01
6.86E-02
ns
1.04E-05
1.21E-07
ns
6.73E-02
8.19E-09
1.10E-07
2.81E-02
1.81E-02
2.31E-02
2.37E-02
2.93E-01
ns
9.86E-01
ns
8.67E-09
2.68E-03
5.66E-02
ns
ns
3.41E-02
2.74E-02
7.35E-04
9.86E-03
1.14E-03
5.63E-01
1.97E-01
ns
2.56E-01
ns
3.31E-01
1.50E-02
ns
1.73E-01
ns
ns
1.81E-05
2.75E-02
1.43E-02
3.63E-03
3.00E-03
1.90E-01
4.19E-03
ns
7.23E-01
1.46E-01
1.02E-07
4.79E-01
8.63E-02
7.23E-02
2.98E-04
5.65E-03
ns
4.26E-01
1.60E-03
8.51E-01
2.55E-10
4.51E-02
1.05E-01
ns
5.44E-05
5.67E-03
3.87E-03
8.76E-05
2.70E-01
1.16E-02
7.59E-02
1.67E-01
2.27E-01
2.79E-02
ns
-?
-++
--+
--+
--++
++
+-+?
+?
?
-+
---?
-+
+--+
++
-+
--+
?+
--+
---+
--+
-+
+-++
+-+
--+
-++
++
-++
-+
-+
-?
-+
-+
--?
++
---++
+?
-++
-+
++
?+
-+
-+
--++----?
-+
-++
--?
-++
-?
-+
-+
?+
--+
-?
++
-+
-++
--+
-?
+-++
--+
?-+
-+
-+
++
---+-+
+-+
-+
--+--?
++
--+
+--++
-+
++
++
-?
++
-+
+?
++
++
++
-+
--+
--+?
+?
--+
?-+
213
567
567
567
567
567
567
567
567
567
567
567
567
567
0
213
0
567
567
567
213
567
567
567
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
567
213
567
567
567
567
567
213
567
567
567
567
354
567
567
567
567
567
567
567
567
567
213
567
567
567
567
213
567
567
213
567
567
354
567
567
213
567
567
567
567
567
567
213
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
567
213
567
567
213
567
567
567
567
567
567
567
567
213
213
567
567
354
567
-0.260
-1.614
0.897
-3.290
0.397
-3.748
-0.249
-2.480
-2.773
2.802
1.263
-0.651
-3.135
0.176
ns
1.216
ns
0.256
-0.147
-1.657
-1.943
-0.091
-0.307
-1.569
1.266
1.151
0.535
-2.413
-0.864
1.726
-2.693
1.109
-2.623
-3.913
1.582
-1.452
0.850
1.023
-0.427
-1.322
2.191
-0.771
1.372
-1.485
-0.825
-1.519
3.080
3.365
-4.579
2.745
-0.344
0.566
-0.294
0.293
0.580
-2.262
-0.117
0.296
-1.927
-0.948
-0.327
2.666
0.404
-1.882
2.175
1.552
1.363
4.995
1.830
-0.116
-2.869
-0.591
-0.923
-0.980
-2.461
-1.627
-1.263
-1.665
-0.365
-2.056
1.073
-2.325
-0.189
-1.358
1.638
-0.148
-0.315
0.297
1.134
-1.927
-0.446
-0.098
2.885
1.824
-0.622
3.062
-2.139
-0.945
-0.428
-0.286
-2.666
2.206
-1.629
0.869
-0.880
0.695
0.023
-0.130
0.931
-1.194
-3.251
-1.313
1.727
0.254
0.162
1.533
-0.520
-2.429
-2.696
-1.933
-3.189
-1.063
1.472
-3.745
1.371
0.743
-2.436
-2.757
3.543
-0.127
3.141
2.156
-0.530
1.063
-0.392
0.824
2.413
1.634
2.255
-0.866
-2.301
-1.341
-1.791
-3.245
0.068
1.815
-3.492
0.874
-2.374
0.474
7.95E-01
1.07E-01
3.70E-01
1.00E-03
6.92E-01
1.78E-04
8.04E-01
1.31E-02
5.56E-03
5.08E-03
2.06E-01
5.15E-01
1.72E-03
8.61E-01
ns
2.24E-01
ns
7.98E-01
8.83E-01
9.76E-02
5.20E-02
9.27E-01
7.59E-01
1.17E-01
2.06E-01
2.50E-01
5.93E-01
1.58E-02
3.88E-01
8.43E-02
7.08E-03
2.68E-01
8.71E-03
9.11E-05
1.14E-01
1.47E-01
3.95E-01
3.06E-01
6.69E-01
1.86E-01
2.85E-02
4.41E-01
1.70E-01
1.38E-01
4.10E-01
1.29E-01
2.07E-03
7.66E-04
4.67E-06
6.05E-03
7.31E-01
5.72E-01
7.69E-01
7.70E-01
5.62E-01
2.37E-02
9.07E-01
7.67E-01
5.40E-02
3.43E-01
7.44E-01
7.67E-03
6.86E-01
5.98E-02
2.97E-02
1.21E-01
1.73E-01
5.89E-07
6.73E-02
9.08E-01
4.11E-03
5.55E-01
3.56E-01
3.27E-01
1.39E-02
1.04E-01
2.07E-01
9.59E-02
7.15E-01
3.98E-02
2.83E-01
2.01E-02
8.50E-01
1.75E-01
1.01E-01
8.82E-01
7.53E-01
7.67E-01
2.57E-01
5.40E-02
6.55E-01
9.22E-01
3.91E-03
6.82E-02
5.34E-01
2.20E-03
3.25E-02
3.45E-01
6.69E-01
7.75E-01
7.67E-03
2.74E-02
1.03E-01
3.85E-01
3.79E-01
4.87E-01
9.82E-01
8.97E-01
3.52E-01
2.32E-01
1.15E-03
1.89E-01
8.42E-02
7.99E-01
8.71E-01
1.25E-01
6.03E-01
1.51E-02
7.01E-03
5.33E-02
1.43E-03
2.88E-01
1.41E-01
1.81E-04
1.70E-01
4.57E-01
1.49E-02
5.83E-03
3.95E-04
8.99E-01
1.68E-03
3.11E-02
5.96E-01
2.88E-01
6.95E-01
4.10E-01
1.58E-02
1.02E-01
2.41E-02
3.87E-01
2.14E-02
1.80E-01
7.34E-02
1.18E-03
9.46E-01
6.96E-02
4.79E-04
3.82E-01
1.76E-02
6.36E-01
+
+
+
?
+
+
?
+
+
?
?
+
+
+
+
+
+
+
?
+
?
+
?
+
+
+
+
?
?
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
?
+
+
+
+
?
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
?
+
?
+
+
+
?
-
869
869
869
869
0
869
869
869
869
0
869
869
869
869
869
869
0
0
869
869
869
869
869
869
869
869
869
869
869
0
869
0
869
869
0
869
869
869
869
869
0
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
0
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
0
869
869
869
869
869
869
869
869
869
0
869
0.001
0.003
0.001
-0.002
ns
0.006
0.001
-0.003
-0.001
ns
0.006
-0.001
-0.002
-0.001
-0.003
0.002
ns
ns
0.003
0.006
0.001
0.002
0.001
-0.001
0.000
-0.005
0.003
0.000
-0.002
ns
0.001
ns
-0.002
0.001
ns
0.003
-0.003
0.002
0.000
0.004
ns
-0.002
ns
-0.003
-0.006
0.001
0.000
0.002
0.002
-0.001
0.000
0.002
-0.003
0.002
0.002
-0.001
0.002
-0.003
0.002
0.002
0.001
0.000
0.001
0.004
ns
0.001
0.000
0.000
-0.004
0.005
0.003
0.003
0.001
0.008
-0.002
0.001
0.002
ns
-0.001
0.001
-0.001
-0.003
-0.008
-0.004
-0.001
-0.001
0.003
0.003
0.003
-0.001
0.001
0.011
-0.006
0.002
ns
0.004
0.000
0.002
0.002
ns
-0.002
0.004
0.002
-0.001
ns
-0.006
0.002
-0.004
-0.001
0.000
0.001
0.001
0.000
0.001
0.001
0.001
-0.003
0.005
0.001
0.001
0.001
0.000
-0.003
0.002
-0.002
0.000
-0.004
-0.002
0.001
0.003
-0.005
0.001
0.003
0.004
-0.001
ns
0.001
0.000
ns
0.000
-0.004
-0.003
0.002
-0.001
0.000
-0.001
0.003
-0.002
ns
-0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
ns
ns
0.001
0.001
0.002
0.001
0.001
0.001
0.002
0.002
0.002
0.001
0.001
ns
0.001
ns
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
ns
0.002
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.003
0.002
0.001
0.002
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.003
0.002
0.001
0.001
0.001
0.004
0.001
0.001
0.001
0.002
0.003
0.001
ns
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.002
0.001
0.001
0.003
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.002
0.001
0.002
ns
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.002
0.002
0.001
0.001
0.001
ns
0.001
4.85E-01
4.52E-03
5.44E-01
1.74E-02
ns
1.38E-05
5.28E-01
3.93E-03
1.75E-01
ns
3.86E-09
3.05E-01
8.37E-02
1.46E-01
4.92E-03
1.86E-01
ns
ns
4.21E-02
2.13E-06
5.52E-01
8.59E-02
9.44E-02
3.88E-01
8.16E-01
1.10E-03
1.12E-01
9.80E-01
3.40E-02
ns
3.78E-01
ns
1.81E-02
4.71E-01
ns
3.17E-03
4.29E-02
1.99E-03
8.36E-01
2.80E-03
ns
1.81E-01
ns
2.69E-03
3.30E-05
1.09E-01
8.00E-01
2.84E-02
8.89E-02
4.66E-01
6.84E-01
1.88E-02
1.58E-02
9.34E-02
1.96E-02
3.17E-01
5.84E-02
2.87E-01
3.00E-01
3.34E-02
5.67E-01
7.44E-01
1.72E-01
3.23E-03
ns
2.73E-01
7.75E-01
8.34E-01
4.06E-02
2.01E-04
5.60E-03
1.29E-02
4.41E-01
5.76E-05
3.68E-03
2.50E-01
5.79E-02
ns
1.99E-01
1.78E-01
1.48E-02
2.23E-02
1.86E-03
6.36E-02
9.59E-02
9.93E-02
1.29E-03
3.95E-01
6.51E-03
3.89E-01
1.89E-01
7.48E-06
7.18E-02
1.60E-02
ns
1.60E-06
6.96E-01
1.25E-01
1.86E-01
ns
3.66E-02
2.07E-07
3.98E-02
2.58E-01
ns
6.23E-08
9.69E-03
8.23E-04
1.87E-01
9.79E-01
4.85E-01
3.45E-01
7.66E-01
1.78E-01
1.04E-01
4.08E-02
7.15E-02
2.73E-04
4.89E-01
6.64E-01
4.89E-01
4.69E-01
8.74E-02
1.07E-01
1.02E-01
9.26E-01
4.82E-04
2.69E-02
3.40E-01
6.00E-03
1.56E-04
6.10E-01
1.94E-01
8.14E-08
5.52E-01
ns
6.79E-01
9.50E-01
ns
9.46E-01
5.34E-03
1.08E-02
9.73E-02
7.57E-01
9.04E-01
5.72E-01
1.68E-02
9.30E-02
ns
6.04E-01
?
+
?
?
?
?
?
?
?
?
+
?
?
?
?
+
?
?
?
?
?
?
+
?
+
?
?
?
+
?
?
?
?
?
?
?
?
+
?
?
+
+
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
?
+
?
+
?
?
?
+
?
?
?
+
?
?
?
+
?
?
?
?
?
+
?
?
?
?
+
?
?
?
?
+
+
?
?
?
+
?
?
?
?
+
?
?
?
+
?
?
1244
0
1244
1244
0
0
1244
1244
0
0
0
1244
1244
0
0
1244
0
1244
0
0
1244
0
1244
0
1244
1244
1244
0
1244
0
0
0
0
0
1244
0
1244
0
0
0
1244
0
0
1244
0
0
0
0
0
0
1244
0
0
1244
1244
1244
1244
1244
0
0
0
0
0
1244
1244
0
0
0
0
0
0
0
0
1244
0
0
0
0
0
1244
1244
0
0
0
0
0
1244
0
1244
1244
0
1244
0
0
0
1244
0
0
1244
0
1244
1244
1244
0
0
0
1244
0
0
0
1244
1244
0
0
1244
1244
0
0
1244
0
1244
1244
0
1244
1244
0
0
0
0
1244
1244
1244
0
0
0
1244
1244
0
0
0
0
1244
1244
1244
0
0
0
1244
0
0
-0.003
ns
0.002
-0.002
ns
ns
-0.001
-0.004
ns
ns
ns
-0.001
-0.001
ns
ns
-0.001
ns
0.001
ns
ns
-0.003
ns
0.000
ns
-0.001
0.001
-0.004
ns
-0.003
ns
ns
ns
ns
ns
0.002
ns
0.000
ns
ns
ns
0.007
ns
ns
-0.002
ns
ns
ns
ns
ns
ns
0.002
ns
ns
-0.001
-0.001
-0.003
0.004
0.000
ns
ns
ns
ns
ns
-0.001
0.004
ns
ns
ns
ns
ns
ns
ns
ns
-0.003
ns
ns
ns
ns
ns
-0.001
0.004
ns
ns
ns
ns
ns
-0.001
ns
-0.002
0.002
ns
0.001
ns
ns
ns
0.002
ns
ns
-0.003
ns
-0.003
0.004
-0.001
ns
ns
ns
0.000
ns
ns
ns
-0.001
-0.002
ns
ns
-0.001
0.002
ns
ns
-0.001
ns
-0.002
-0.001
ns
-0.002
0.001
ns
ns
ns
ns
-0.001
0.001
0.007
ns
ns
ns
-0.001
0.004
ns
ns
ns
ns
-0.001
-0.001
0.002
ns
ns
ns
0.001
ns
ns
0.001
ns
0.001
0.001
ns
ns
0.000
0.001
ns
ns
ns
0.000
0.000
ns
ns
0.000
ns
0.001
ns
ns
0.000
ns
0.000
ns
0.000
0.000
0.000
ns
0.000
ns
ns
ns
ns
ns
0.001
ns
0.000
ns
ns
ns
0.001
ns
ns
0.000
ns
ns
ns
ns
ns
ns
0.001
ns
ns
0.000
0.000
0.001
0.000
0.001
ns
ns
ns
ns
ns
0.000
0.000
ns
ns
ns
ns
ns
ns
ns
ns
0.001
ns
ns
ns
ns
ns
0.000
0.000
ns
ns
ns
ns
ns
0.000
ns
0.000
0.001
ns
0.000
ns
ns
ns
0.000
ns
ns
0.000
ns
0.001
0.001
0.000
ns
ns
ns
0.000
ns
ns
ns
0.000
0.000
ns
ns
0.001
0.001
ns
ns
0.000
ns
0.000
0.000
ns
0.001
0.000
ns
ns
ns
ns
0.000
0.001
0.002
ns
ns
ns
0.000
0.001
ns
ns
ns
ns
0.000
0.000
0.000
ns
ns
ns
0.000
ns
ns
1.52E-03
ns
2.57E-05
5.59E-04
ns
ns
1.04E-01
4.29E-14
ns
ns
ns
1.70E-04
7.14E-04
ns
ns
6.66E-06
ns
1.01E-01
ns
ns
3.45E-27
ns
6.24E-01
ns
2.42E-04
3.39E-09
4.60E-13
ns
1.61E-08
ns
ns
ns
ns
ns
2.59E-05
ns
9.05E-01
ns
ns
ns
5.62E-15
ns
ns
4.08E-07
ns
ns
ns
ns
ns
ns
4.36E-04
ns
ns
9.21E-08
3.34E-02
3.87E-10
1.92E-15
5.25E-01
ns
ns
ns
ns
ns
1.96E-03
4.47E-14
ns
ns
ns
ns
ns
ns
ns
ns
5.21E-04
ns
ns
ns
ns
ns
1.64E-05
4.35E-14
ns
ns
ns
ns
ns
1.90E-02
ns
5.10E-06
7.94E-04
ns
7.64E-10
ns
ns
ns
1.27E-07
ns
ns
9.54E-13
ns
1.78E-04
1.65E-15
1.01E-03
ns
ns
ns
4.27E-01
ns
ns
ns
1.37E-04
1.05E-05
ns
ns
2.95E-01
9.12E-06
ns
ns
3.75E-04
ns
1.83E-07
2.10E-04
ns
1.23E-04
1.39E-04
ns
ns
ns
ns
1.19E-02
2.73E-01
2.33E-04
ns
ns
ns
2.64E-06
4.91E-05
ns
ns
ns
ns
7.99E-10
1.71E-04
3.02E-06
ns
ns
ns
1.07E-01
ns
ns
-+
-+
++
-+
+?
-+
--++
--++
+-+
+?
-?
-?
+-++
---+
--?
++
--+
-+
+?
-+
++-+
++
-+
++
-+
-+
-++
++
+-+
--+
++
++
-+
++
++
++
-+
---+
++
++
+-?
++
-+
--+?
++
-+?
0+
--++
-?
+-+
-+
-+?
--++
---+
-+
-+
-++
-++
+++
+--++
----?
-++
+-+
+?
-+
++
++
-+
-+
+-+
++
+?
++
+--+
-+
-+
++
-+
++
----+
-++
-+
++-+
++
--++
++
++
--+
-+++
-+
+-+
++
-?
++
362
362
362
362
134
362
362
362
362
362
362
362
362
362
134
134
134
362
362
362
362
362
362
362
134
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
134
362
362
134
362
362
362
362
134
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
134
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
-0.021
-0.059
0.830
-0.181
0.404
-0.251
-3.513
-0.622
2.139
-3.172
-1.200
1.024
-0.739
-0.034
0.507
-2.346
-2.763
-0.671
-2.798
0.605
-1.791
-1.783
0.874
-1.837
-0.808
2.365
-3.032
-0.553
-0.783
0.030
-0.313
-1.234
-0.192
0.070
1.111
-0.935
0.424
0.297
-0.047
-3.066
2.136
0.080
-1.209
-1.113
-1.293
1.315
1.673
0.223
-0.111
2.131
1.651
0.691
-0.726
-2.916
-2.250
0.152
1.392
1.842
-0.432
-0.721
1.579
0.127
-2.220
-2.500
0.015
0.035
-1.629
0.116
1.691
-1.312
-1.528
0.500
-1.092
-0.891
0.970
0.005
-0.992
0.364
-2.307
-1.361
0.366
-1.900
-1.174
-1.323
-0.522
-0.731
-1.645
1.309
-2.048
0.705
-0.947
3.832
0.257
-2.402
-1.667
0.174
-2.061
-2.062
-1.627
-2.020
-3.130
1.228
-1.720
-1.049
0.029
0.472
0.075
1.250
-0.034
0.776
-0.701
-1.006
1.694
0.004
2.563
-0.166
-2.379
-0.041
-1.121
-0.435
0.679
-0.159
1.438
-1.589
-1.420
-1.165
-0.829
-3.298
1.550
-1.147
-0.532
0.032
-0.176
0.719
-3.806
-2.683
0.447
0.870
1.049
-2.693
-0.207
-1.784
-0.260
1.048
0.635
-1.623
0.257
1.771
-1.363
1.696
9.84E-01
9.53E-01
4.07E-01
8.57E-01
6.86E-01
8.02E-01
4.43E-04
5.34E-01
3.25E-02
1.52E-03
2.30E-01
3.06E-01
4.60E-01
9.73E-01
6.12E-01
1.90E-02
5.72E-03
5.03E-01
5.15E-03
5.45E-01
7.32E-02
7.45E-02
3.82E-01
6.62E-02
4.19E-01
1.81E-02
2.43E-03
5.81E-01
4.34E-01
9.76E-01
7.55E-01
2.17E-01
8.48E-01
9.44E-01
2.66E-01
3.50E-01
6.72E-01
7.67E-01
9.63E-01
2.17E-03
3.27E-02
9.36E-01
2.27E-01
2.66E-01
1.96E-01
1.88E-01
9.44E-02
8.23E-01
9.11E-01
3.31E-02
9.88E-02
4.90E-01
4.68E-01
3.55E-03
2.45E-02
8.79E-01
1.64E-01
6.54E-02
6.66E-01
4.71E-01
1.14E-01
8.99E-01
2.65E-02
1.24E-02
9.88E-01
9.72E-01
1.03E-01
9.08E-01
9.08E-02
1.90E-01
1.27E-01
6.17E-01
2.75E-01
3.73E-01
3.32E-01
9.96E-01
3.21E-01
7.16E-01
2.11E-02
1.74E-01
7.15E-01
5.74E-02
2.40E-01
1.86E-01
6.02E-01
4.65E-01
9.99E-02
1.91E-01
4.05E-02
4.81E-01
3.44E-01
1.27E-04
7.97E-01
1.63E-02
9.55E-02
8.62E-01
3.93E-02
3.92E-02
1.04E-01
4.34E-02
1.75E-03
2.19E-01
8.54E-02
2.94E-01
9.77E-01
6.37E-01
9.40E-01
2.11E-01
9.73E-01
4.38E-01
4.83E-01
3.14E-01
9.02E-02
9.97E-01
1.04E-02
8.68E-01
1.74E-02
9.68E-01
2.62E-01
6.63E-01
4.97E-01
8.74E-01
1.51E-01
1.12E-01
1.56E-01
2.44E-01
4.07E-01
9.74E-04
1.21E-01
2.51E-01
5.95E-01
9.74E-01
8.60E-01
4.72E-01
1.41E-04
7.31E-03
6.55E-01
3.85E-01
2.94E-01
7.08E-03
8.36E-01
7.44E-02
7.95E-01
2.95E-01
5.25E-01
1.05E-01
7.97E-01
7.66E-02
1.73E-01
8.98E-02
67717
1670
56658
20844
55298
41942
55194
34130
68115
64743
43301
40373
19552
56003
48908
45909
23198
32696
55301
33055
53780
43292
61890
47603
25166
5878
53063
28615
38878
49663
55622
14891
52888
42247
14696
61807
65926
19149
68307
3345
2072
8050
49930
34287
4576
35327
28311
53538
58154
2474
67352
42780
1206
53825
32700
66441
49554
18970
8647
49500
38645
32826
12448
13455
17364
51448
24918
37749
38978
1521
54114
3839
57739
18435
11238
11822
10499
66533
21501
56566
21931
64977
15588
12570
50623
58135
20700
30028
60036
3017
9412
46627
7856
37377
26846
65026
3843
33853
13162
16198
21509
54226
63986
28734
37284
50483
55317
56295
39327
12209
37891
14077
53753
46193
45166
55076
33975
7658
2279
4798
61456
7762
40439
38897
66147
24315
39364
30996
14227
41018
54493
28612
34217
48798
39910
13
51744
36381
25048
60032
25918
47086
50495
39981
47092
62502
3760
5566
3372
30522
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
23279
10099
3340
1786
114884
83857
23580
64755
6594
51338
151258
79668
6187
23028
55803
10906
4864
283345
9242
3101
83716
6472
5176
10859
9987
64318
79726
219738
25976
152189
55035
158038
29090
285636
220002
51114
6929
9792
915
168537
9221
79680
8666
23107
2633
27292
219743
6441
26207
27242
94039
64682
147657
3458
55299
23224
55603
10171
122060
5876
55711
59
51754
93594
5578
23344
79673
6604
222161
3162
26009
9823
22990
51504
8886
3084
91746
10807
1534
3959
738
80129
9056
257101
7130
23312
942
10533
23303
7431
826
114908
79690
157567
10954
3140
3066
56978
6480
11145
9644
2799
84186
3755
10155
55350
6143
84705
4318
84329
3516
4216
28232
10799
5627
27250
23092
4049
2058
55824
284207
1432
158219
84245
5351
64776
29094
51280
23076
2629
3674
7705
6217
57019
3184
64224
7155
4809
1511
150290
51181
3148
81571
4353
11168
64127
79158
5287
6948
56941
NUP160
TSPAN3
NDST1
DNMT1
OSBPL10
TMTC1
CDC42EP4
C16orf58
SMARCA1
MS4A4A
SLC38A11
PARP8
RPS2
KDM1A
ADAP2
TRAFD1
NPC1
RPL13P5
MSC
HK3
CRISPLD2
SHMT2
SERPINF1
LILRB1
HNRPDL
NOC3L
WDR59
C10orf35
TIPARP
CMTM8
NOL8
LINGO2
TIMM21
C5orf51
CYBASC3
ZDHHC9
TCF3
SERTAD2
CD3D
GIMAP7
NOLC1
C22orf29
EIF3G
MRPS27
GBP1
DIMT1
TYSND1
SFTPD
PITPNC1
TNFRSF21
ZNF101
ANAPC1
ZNF480
IFNG
BRIX1
SYNE2
FAM46A
RCL1
SLAIN1
RABGGTB
FAR2
ACTA2
TMEM8B
WDR67
PRKCA
ESYT1
ZNF329
SMARCD3
DKFZP586I1420
HMOX1
ZZZ3
ARMCX2
PCNX
TRMT112
DDX18
NRG1
YTHDC1
SDCCAG3
CYB561
LGALS3BP
VPS51
CCDC170
SLC7A7
ZNF683
TNFAIP6
DMXL2
CD86
ATG7
KIF13B
VIM
CAPNS1
TMEM123
GAL3ST4
ANKRD46
PDIA5
MR1
HDAC2
PRDM8
ST6GAL1
PLA2G16
SH3PXD2A
GNS
ZCCHC7
KCNG1
TRIM28
VNN3
RPL19
GTPBP3
MMP9
HVCN1
RBPJ
MAP3K4
SLCO3A1
RPP40
PROS1
PDCD4
ARHGAP26
LTA
EPRS
PAG1
METRNL
MAPK14
TTC39B
MRI1
PLOD1
C11orf1
LGALSL
GOLM1
RRP1B
GBA
ITGA2B
ZNF146
RPS16
CIAPIN1
HNRNPD
HERPUD2
TOP2B
NHP2L1
CTSG
DUSP18
DCXR
HMGB2
MIR600HG
MPO
PSIP1
NOD2
GNPTAB
PIK3C2B
TCN2
C3orf37
----------++++++
----------++++++
++++++
---------++-++++
-----++++++
--------+-++++++
++++++
++-+++
-----++++++
++++++
++++++
-------+--++++++
--------------------++++++
---?------++-+++
---------------+
------------------?--------------------------++++++
----------+
++-+++
-------+---------------?-++++++
-----++-+++
++++++
--------?------+++?++
++++++
---?---------------------++++++
++++++
++++++
--------?-+++-++
----------++++++
----------++-+++
-----------++-++
-+++++
++-+++
++++++
+-++++
++++++
++++++
++-+++
++++++
++-+++
-------+-+----------++++++
--+--+-+-++
-----++-+++
-----++++++
---------------+
++++++
-----+
-----+
++++++
---?-++++++
-----++++++
---+-+++++-----++++++
---------------++++++
++++++
+---------++++++
-----++++++
++++++
-----++++++
++++++
--------?----+------++++++
----------++++++
++++++
---?-+++?++
-----++++++
--+--++++++
++-+++
-----++++++
------
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
-9.029
-8.369
7.752
-8.654
-7.185
6.425
7.161
-6.999
-6.165
9.032
-7.329
6.948
-6.475
-6.880
8.149
6.755
8.274
-5.402
8.901
9.226
7.907
-6.029
-5.652
6.743
-7.103
-7.444
-8.309
-8.664
6.471
-7.113
-7.899
6.554
-7.245
-7.190
-6.234
-7.582
-5.847
-7.705
-7.574
-8.769
-8.078
-6.041
-7.055
-7.326
7.651
-8.395
-5.096
5.644
-6.571
-5.995
-8.139
-8.227
-7.051
7.162
-7.588
4.628
6.904
-8.594
-7.344
-7.069
6.739
6.200
-5.920
-7.159
-9.570
-7.550
-7.873
7.922
5.886
6.492
-7.904
-7.506
4.803
-5.820
-7.008
7.561
-7.205
-6.882
6.222
-6.680
-6.693
6.586
8.232
8.641
7.412
7.133
7.801
8.406
7.024
7.919
7.657
-7.111
-4.673
-8.011
-5.702
7.800
-5.869
5.257
-6.767
5.842
-6.640
7.656
-7.342
-6.899
-7.012
5.579
-7.975
-6.042
7.903
-5.502
8.218
-9.101
7.528
-6.388
6.603
-7.827
6.367
-7.762
-8.045
-9.420
8.973
7.273
-6.527
-6.818
8.048
-7.246
5.997
8.614
-7.543
7.015
7.350
-7.026
-5.305
-6.051
-7.027
8.104
-7.865
-6.919
7.385
7.392
-5.436
7.883
-6.825
8.274
-7.208
6.063
6.062
-8.696
6.914
-7.074
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.73E-19
5.80E-17
9.02E-15
4.98E-18
6.73E-13
1.32E-10
7.99E-13
2.58E-12
7.03E-10
1.69E-19
2.31E-13
3.70E-12
9.51E-11
5.99E-12
3.66E-16
1.43E-11
1.29E-16
6.59E-08
5.55E-19
2.81E-20
2.63E-15
1.65E-09
1.58E-08
1.55E-11
1.22E-12
9.78E-14
9.63E-17
4.54E-18
9.73E-11
1.14E-12
2.81E-15
5.59E-11
4.33E-13
6.46E-13
4.53E-10
3.40E-14
5.01E-09
1.31E-14
3.61E-14
1.81E-18
6.56E-16
1.53E-09
1.73E-12
2.38E-13
1.99E-14
4.65E-17
3.46E-07
1.66E-08
5.01E-11
2.04E-09
3.99E-16
1.91E-16
1.78E-12
7.94E-13
3.24E-14
3.70E-06
5.07E-12
8.41E-18
2.07E-13
1.57E-12
1.59E-11
5.65E-10
3.22E-09
8.14E-13
1.07E-21
4.34E-14
3.45E-15
2.34E-15
3.95E-09
8.47E-11
2.69E-15
6.10E-14
1.56E-06
5.90E-09
2.43E-12
4.01E-14
5.82E-13
5.89E-12
4.92E-10
2.39E-11
2.19E-11
4.53E-11
1.84E-16
5.59E-18
1.25E-13
9.84E-13
6.14E-15
4.25E-17
2.16E-12
2.39E-15
1.90E-14
1.16E-12
2.97E-06
1.14E-15
1.19E-08
6.18E-15
4.38E-09
1.47E-07
1.32E-11
5.17E-09
3.15E-11
1.91E-14
2.11E-13
5.25E-12
2.35E-12
2.42E-08
1.53E-15
1.52E-09
2.72E-15
3.76E-08
2.07E-16
8.98E-20
5.17E-14
1.68E-10
4.02E-11
5.00E-15
1.93E-10
8.39E-15
8.62E-16
4.51E-21
2.88E-19
3.51E-13
6.69E-11
9.24E-12
8.44E-16
4.31E-13
2.01E-09
7.05E-18
4.58E-14
2.31E-12
1.98E-13
2.12E-12
1.13E-07
1.44E-09
2.11E-12
5.33E-16
3.70E-15
4.56E-12
1.52E-13
1.45E-13
5.46E-08
3.21E-15
8.78E-12
1.30E-16
5.68E-13
1.34E-09
1.34E-09
3.45E-18
4.72E-12
1.51E-12
-----+-+
---+---+
++++++-+
-------+
---+---+
++++++++
++++++++
--------+-???+--+++??+
+--+--?+++-++++
--------------+++++-++
++++++++
+++-++++
--------+++++?+
++++++++
++++++++
----------?-??++++++++
---------------------+--+---+++++-++
------------+-+++?+??+
----------+----------+--+--------+-----------------------+------------------------+-++++++++
--------------++++++++
-----+------+-+-----------+----+---++++++++
-------+-++++++
++++++++
----------+--------+-+++++-++
++++--++
-----+-----------+---+
----------+---+-++++++
++++++++
++++++++
-------------?++++++++
---+----------+++++-?+
--------------++++--+---------------++++??+
+-++++++
-++-++++
++++++++
+++--+++
+++++-++
+++-+-++
++++++++
++++++++
++++++++
-----------++------------+--+++-++++
-------+++++-++
-------+
+++-++++
-----+-++++++++
--------+-+--------+-++++++++
-------+
-------+++-++-+
---+---++++++++
-------++++-+++
-------++++-+++
--+--+-++++++++
---+-----------------++++++++++-+0++
------------+-+++-++-+
-------++++++++
+++++-++
-------+++-++++
-+++++++
-------------------+---------+-+-+++
-----------+--++++++++
++++++++
---+---+-++-+-+
---+---+
++++++++
-------++++++++
+++-++++
---+--+++++++++
-------+
8009
8009
8009
8009
8009
8009
8009
8009
7302
6325
6552
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
6552
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
-5.54
-6.16
6.75
-5.89
-7.26
7.96
7.25
-7.40
-8.24
5.24
-7.06
7.42
-7.87
-7.48
6.27
7.57
6.12
-8.85
5.34
5.20
6.43
-8.22
-8.78
7.49
-7.14
-6.81
-5.98
-5.64
7.73
-7.13
-6.37
7.74
-6.98
-7.01
-7.91
-6.61
-8.26
-6.49
-6.66
-5.47
-6.12
-8.06
-7.08
-6.83
6.51
-5.80
-8.94
8.41
-7.52
-8.06
-6.01
-5.91
-7.05
6.92
-6.51
9.32
7.15
-5.53
-6.76
-6.98
7.30
7.81
-8.02
-6.89
-4.59
-6.52
-6.20
6.16
8.09
7.51
-6.16
-6.50
9.10
-8.12
-6.98
6.39
-6.77
-7.08
7.71
-7.27
-7.25
7.40
5.77
5.37
6.54
6.79
6.15
5.58
6.88
6.01
6.26
-6.77
-9.08
-5.91
-8.10
6.09
-7.92
8.50
-7.06
7.94
-7.18
6.21
-6.50
-6.92
-6.79
8.15
-5.86
-7.69
5.92
-8.14
5.62
-4.77
6.25
-7.32
7.10
-5.93
7.32
-5.98
-5.70
-4.38
4.81
6.41
-7.11
-6.83
5.66
-6.42
7.61
5.11
-6.12
6.62
6.29
-6.59
-8.16
-7.52
-6.59
5.56
-5.78
-6.68
6.23
6.22
-8.01
5.83
-6.75
5.35
-6.36
7.45
7.43
-4.92
6.62
-6.46
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
3.10E-08
7.11E-10
1.48E-11
3.89E-09
3.98E-13
1.67E-15
4.07E-13
1.32E-13
1.80E-16
1.62E-07
1.71E-12
1.14E-13
3.43E-15
7.26E-14
3.60E-10
3.84E-14
9.45E-10
8.57E-19
9.52E-08
2.03E-07
1.25E-10
2.03E-16
1.59E-18
7.18E-14
9.31E-13
9.90E-12
2.19E-09
1.68E-08
1.08E-14
9.76E-13
1.93E-10
1.03E-14
2.99E-12
2.38E-12
2.55E-15
3.74E-11
1.42E-16
8.37E-11
2.73E-11
4.46E-08
9.16E-10
7.82E-16
1.40E-12
8.81E-12
7.38E-11
6.56E-09
3.83E-19
4.05E-17
5.39E-14
7.53E-16
1.83E-09
3.36E-09
1.82E-12
4.57E-12
7.52E-11
1.13E-20
8.90E-13
3.14E-08
1.39E-11
2.87E-12
2.96E-13
5.78E-15
1.04E-15
5.56E-12
4.34E-06
7.28E-11
5.51E-10
7.48E-10
6.19E-16
5.99E-14
7.42E-10
7.83E-11
9.43E-20
4.59E-16
3.05E-12
1.65E-10
1.27E-11
1.47E-12
1.30E-14
3.64E-13
4.13E-13
1.32E-13
7.87E-09
7.99E-08
6.27E-11
1.09E-11
7.56E-10
2.48E-08
6.21E-12
1.81E-09
3.81E-10
1.30E-11
1.05E-19
3.51E-09
5.47E-16
1.16E-09
2.39E-15
1.90E-17
1.71E-12
2.09E-15
7.20E-13
5.46E-10
8.16E-11
4.54E-12
1.11E-11
3.64E-16
4.67E-09
1.44E-14
3.28E-09
4.10E-16
1.97E-08
1.81E-06
4.06E-10
2.42E-13
1.24E-12
3.08E-09
2.58E-13
2.20E-09
1.17E-08
1.16E-05
1.51E-06
1.45E-10
1.16E-12
8.31E-12
1.55E-08
1.37E-10
2.84E-14
3.24E-07
9.24E-10
3.58E-11
3.25E-10
4.30E-11
3.44E-16
5.64E-14
4.55E-11
2.72E-08
7.44E-09
2.43E-11
4.73E-10
4.97E-10
1.11E-15
5.72E-09
1.53E-11
8.68E-08
2.00E-10
9.26E-14
1.08E-13
8.57E-07
3.72E-11
1.03E-10
15266
15266
15266
15266
15266
15266
15266
15266
14559
13582
13809
15266
15266
15266
15266
15266
15266
15266
13809
15266
15266
15266
13223
15266
15266
15266
15266
15266
15266
14385
15266
13223
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
14385
15266
14385
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
12928
15266
15266
15266
13809
15266
15266
15266
15266
15266
13582
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
14385
14385
15266
15266
15266
15266
15266
15266
15266
15266
-10.235
-10.235
10.234
-10.232
-10.21
10.198
10.191
-10.188
-10.185
10.177
-10.174
10.168
-10.167
-10.164
10.16
10.138
10.137
-10.136
10.128
10.125
10.111
-10.111
-10.087
10.07
-10.069
-10.063
-10.063
-10.06
10.06
-10.058
-10.058
10.052
-10.049
-10.035
-10.029
-10.018
-10.016
-10.016
-10.012
-10.009
-10.005
-10.001
-9.995
-9.994
9.993
-9.991
-9.991
9.984
-9.979
-9.972
-9.966
-9.956
-9.953
9.949
-9.947
9.943
9.936
-9.933
-9.933
-9.932
9.931
9.931
-9.927
-9.927
-9.926
-9.925
-9.922
9.92
9.915
9.914
-9.909
-9.901
9.9
-9.895
-9.884
9.883
-9.872
-9.871
9.871
-9.87
-9.867
9.867
9.856
9.845
9.845
9.839
9.836
9.833
9.822
9.816
9.815
-9.805
-9.801
-9.801
-9.798
9.786
-9.783
9.781
-9.776
9.776
-9.775
9.774
-9.768
-9.768
-9.754
9.75
-9.742
-9.738
9.735
-9.733
9.733
-9.732
9.718
-9.709
9.696
-9.69
9.688
-9.684
-9.678
-9.671
9.671
9.658
-9.65
-9.65
9.645
-9.645
9.643
9.64
-9.635
9.632
9.621
-9.62
-9.618
-9.616
-9.614
9.613
-9.61
-9.607
9.603
9.602
-9.599
9.594
-9.591
9.581
-9.577
9.577
9.562
-9.56
9.558
-9.558
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.38E-24
1.39E-24
1.40E-24
1.43E-24
1.80E-24
2.03E-24
2.17E-24
2.23E-24
2.32E-24
2.52E-24
2.59E-24
2.77E-24
2.77E-24
2.88E-24
2.98E-24
3.76E-24
3.80E-24
3.81E-24
4.16E-24
4.28E-24
4.91E-24
4.94E-24
6.29E-24
7.47E-24
7.56E-24
8.02E-24
8.08E-24
8.26E-24
8.29E-24
8.45E-24
8.49E-24
9.05E-24
9.23E-24
1.07E-23
1.14E-23
1.27E-23
1.29E-23
1.30E-23
1.34E-23
1.39E-23
1.45E-23
1.51E-23
1.60E-23
1.62E-23
1.64E-23
1.68E-23
1.68E-23
1.79E-23
1.89E-23
2.02E-23
2.14E-23
2.39E-23
2.45E-23
2.54E-23
2.60E-23
2.70E-23
2.90E-23
2.99E-23
3.00E-23
3.03E-23
3.05E-23
3.07E-23
3.18E-23
3.19E-23
3.21E-23
3.26E-23
3.34E-23
3.39E-23
3.59E-23
3.60E-23
3.79E-23
4.11E-23
4.18E-23
4.37E-23
4.90E-23
4.93E-23
5.48E-23
5.54E-23
5.56E-23
5.61E-23
5.81E-23
5.81E-23
6.46E-23
7.20E-23
7.21E-23
7.66E-23
7.88E-23
8.09E-23
9.04E-23
9.60E-23
9.72E-23
1.07E-22
1.11E-22
1.12E-22
1.15E-22
1.29E-22
1.34E-22
1.37E-22
1.42E-22
1.43E-22
1.44E-22
1.46E-22
1.54E-22
1.54E-22
1.78E-22
1.85E-22
2.00E-22
2.08E-22
2.15E-22
2.17E-22
2.19E-22
2.20E-22
2.52E-22
2.77E-22
3.13E-22
3.34E-22
3.40E-22
3.51E-22
3.73E-22
4.01E-22
4.02E-22
4.55E-22
4.90E-22
4.91E-22
5.15E-22
5.16E-22
5.24E-22
5.44E-22
5.68E-22
5.89E-22
6.52E-22
6.58E-22
6.72E-22
6.84E-22
6.95E-22
7.02E-22
7.29E-22
7.48E-22
7.77E-22
7.87E-22
8.10E-22
8.47E-22
8.70E-22
9.59E-22
9.96E-22
1.00E-21
1.15E-21
1.17E-21
1.20E-21
1.20E-21
+
?
+
?
?
+
?
?
?
+
?
+
+
?
?
?
?
?
+
?
?
+
?
+
?
?
+
?
+
?
+
+
?
+
?
+
?
+
?
?
?
+
?
?
+
+
+
+
?
+
?
+
+
?
+
+
+
?
?
?
?
?
?
+
?
?
?
?
+
+
+
?
+
?
+
?
?
+
?
?
+
?
+
?
?
?
?
+
?
?
+
?
+
+
+
+
?
?
+
?
+
?
?
?
?
+
394
394
0
394
0
0
394
394
0
0
0
394
394
394
0
394
394
394
0
0
0
394
0
0
394
394
394
0
394
0
394
0
394
394
394
0
0
394
0
394
0
394
394
394
0
394
394
0
394
394
0
394
0
0
394
0
394
0
394
394
0
394
394
394
394
394
394
394
394
0
394
0
394
394
394
0
394
394
394
394
394
0
0
0
0
0
0
394
394
0
394
394
0
394
0
0
394
394
394
394
394
394
394
0
394
0
394
394
0
0
394
394
394
394
0
0
394
0
394
394
0
0
0
0
394
394
0
0
394
394
0
394
394
394
394
394
394
394
0
0
394
0
394
0
394
0
0
394
0
394
0.003
-0.013
ns
0.001
ns
ns
-0.002
0.008
ns
ns
ns
-0.004
-0.011
0.009
ns
0.002
-0.009
0.003
ns
ns
ns
-0.004
ns
ns
0.000
-0.004
0.011
ns
0.000
ns
0.009
ns
-0.003
0.006
-0.004
ns
ns
0.006
ns
0.005
ns
0.008
-0.007
0.002
ns
-0.003
0.000
ns
0.002
-0.007
ns
0.012
ns
ns
-0.004
ns
0.002
ns
-0.008
-0.006
ns
0.002
-0.013
0.013
-0.004
0.006
-0.006
0.015
0.000
ns
0.000
ns
0.001
-0.003
0.012
ns
0.006
0.009
0.000
-0.012
0.006
ns
ns
ns
ns
ns
ns
0.002
-0.005
ns
-0.004
-0.004
ns
-0.002
ns
ns
-0.003
-0.013
-0.006
-0.007
0.007
0.008
0.010
ns
0.006
ns
-0.005
0.011
ns
ns
-0.004
0.014
-0.001
-0.006
ns
ns
0.006
ns
-0.003
0.003
ns
ns
ns
ns
0.002
-0.005
ns
ns
0.009
-0.002
ns
0.003
0.003
-0.008
0.007
-0.006
-0.009
0.003
ns
ns
0.005
ns
0.003
ns
-0.006
ns
ns
-0.007
ns
0.003
0.003
0.003
ns
0.004
ns
ns
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
ns
ns
0.004
ns
ns
0.003
0.003
0.002
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.004
0.003
0.004
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.004
0.003
ns
ns
ns
ns
ns
ns
0.003
0.003
ns
0.004
0.003
ns
0.003
ns
ns
0.003
0.003
0.004
0.004
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
0.004
ns
ns
ns
ns
0.003
0.003
ns
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
ns
0.003
ns
ns
0.003
ns
0.003
3.68E-01
5.84E-05
ns
6.77E-01
ns
ns
4.75E-01
1.02E-02
ns
ns
ns
1.93E-01
3.94E-05
1.31E-03
ns
6.23E-01
7.02E-03
2.34E-01
ns
ns
ns
2.51E-01
ns
ns
9.14E-01
1.30E-01
3.18E-06
ns
9.48E-01
ns
3.83E-03
ns
3.08E-01
5.19E-02
1.62E-01
ns
ns
5.63E-02
ns
1.54E-01
ns
2.03E-02
2.57E-02
5.41E-01
ns
3.95E-01
9.94E-01
ns
5.06E-01
2.92E-02
ns
5.09E-05
ns
ns
2.75E-01
ns
6.30E-01
ns
3.40E-03
5.11E-02
ns
5.82E-01
1.77E-04
3.31E-04
2.84E-01
7.55E-02
6.62E-02
6.17E-07
9.64E-01
ns
9.46E-01
ns
6.66E-01
2.35E-01
1.00E-04
ns
6.03E-02
6.02E-03
9.20E-01
1.66E-03
4.96E-02
ns
ns
ns
ns
ns
ns
5.65E-01
1.33E-01
ns
2.46E-01
2.62E-01
ns
4.68E-01
ns
ns
3.50E-01
1.59E-04
7.05E-02
5.85E-02
2.81E-02
1.09E-02
4.70E-03
ns
3.38E-02
ns
1.26E-01
3.54E-04
ns
ns
2.31E-01
7.81E-08
8.18E-01
4.14E-02
ns
ns
6.43E-02
ns
3.84E-01
4.23E-01
ns
ns
ns
ns
5.56E-01
9.23E-02
ns
ns
9.30E-03
5.98E-01
ns
3.19E-01
4.09E-01
9.99E-03
4.62E-02
5.97E-02
5.72E-03
2.89E-01
ns
ns
1.48E-01
ns
4.01E-01
ns
3.45E-02
ns
ns
4.11E-02
ns
2.77E-01
+
+
?
?
+
+
?
?
+
+
+
+
+
+
?
?
+
+
?
?
+
+
+
?
+
+
+
+
?
?
+
?
+
?
+
?
+
+
?
+
+
?
+
?
?
?
+
+
+
+
+
+
+
+
?
+
?
+
+
+
?
+
+
+
+
?
?
?
?
?
?
+
?
+
+
?
?
?
+
+
+
+
+
?
+
+
?
?
+
+
+
+
?
+
?
+
?
?
?
?
+
?
?
?
+
?
+
+
+
+
?
?
+
?
+
?
?
?
+
?
+
394
394
394
394
0
0
394
394
0
0
394
394
394
394
394
394
394
394
0
0
394
394
0
0
394
394
394
0
394
394
394
394
394
394
394
0
0
394
0
394
0
394
394
394
0
394
394
0
394
394
0
394
0
0
394
0
394
394
394
394
394
394
394
394
394
394
394
394
394
0
394
0
394
394
394
0
394
394
394
394
394
0
0
0
0
0
0
394
394
0
394
394
0
394
0
0
394
394
394
394
394
394
394
394
394
0
394
394
0
0
394
394
394
394
394
0
394
0
394
394
0
0
0
0
394
394
0
0
0
394
0
394
394
394
394
394
394
394
0
0
394
0
394
0
394
0
0
394
0
394
0.008
-0.002
0.005
-0.001
ns
ns
0.003
0.007
ns
ns
0.011
0.006
-0.010
0.008
-0.012
0.008
0.009
0.001
ns
ns
0.010
0.008
ns
ns
0.004
0.003
0.009
ns
0.008
-0.007
0.015
-0.005
-0.010
0.015
0.005
ns
ns
0.007
ns
0.003
ns
0.005
-0.002
-0.004
ns
0.010
0.003
ns
0.006
0.001
ns
0.003
ns
ns
-0.002
ns
-0.003
0.011
0.006
0.000
-0.007
0.002
-0.016
0.000
0.003
0.024
-0.012
0.000
0.003
ns
0.007
ns
0.010
0.001
0.012
ns
0.009
0.016
-0.007
0.008
0.007
ns
ns
ns
ns
ns
ns
-0.002
0.011
ns
0.009
0.005
ns
-0.006
ns
ns
-0.003
-0.005
-0.018
0.014
0.013
0.013
0.001
-0.027
0.006
ns
0.006
0.019
ns
ns
0.008
0.012
0.011
-0.008
0.004
ns
0.012
ns
0.003
-0.007
ns
ns
ns
ns
0.014
-0.012
ns
ns
ns
0.001
ns
0.007
0.007
-0.016
0.012
-0.011
-0.006
0.001
ns
ns
0.011
ns
0.000
ns
-0.001
ns
ns
0.004
ns
0.011
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.002
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.004
0.003
ns
ns
ns
ns
ns
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
ns
0.003
0.004
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
0.002
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
ns
ns
ns
ns
0.003
0.003
ns
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
ns
0.002
ns
ns
0.003
ns
0.003
1.12E-02
5.14E-01
1.40E-01
7.86E-01
ns
ns
3.48E-01
4.31E-02
ns
ns
1.98E-03
6.28E-02
9.77E-04
8.29E-03
2.94E-04
2.17E-02
6.48E-03
7.01E-01
ns
ns
3.04E-03
2.67E-02
ns
ns
8.17E-02
2.67E-01
1.91E-03
ns
2.06E-02
2.49E-02
7.30E-06
1.47E-01
4.30E-03
4.51E-10
1.30E-01
ns
ns
2.47E-02
ns
3.05E-01
ns
1.13E-01
5.78E-01
2.11E-01
ns
1.85E-03
3.24E-01
ns
4.10E-02
6.70E-01
ns
3.94E-01
ns
ns
5.26E-01
ns
4.23E-01
9.29E-04
9.24E-02
9.69E-01
3.86E-02
5.71E-01
3.19E-07
9.44E-01
2.79E-01
3.85E-16
3.26E-04
9.97E-01
3.43E-01
ns
3.45E-02
ns
2.26E-03
7.22E-01
9.72E-05
ns
2.78E-03
5.22E-08
5.48E-02
1.72E-02
2.07E-02
ns
ns
ns
ns
ns
ns
4.56E-01
5.40E-04
ns
7.48E-03
1.58E-01
ns
1.03E-01
ns
ns
2.53E-01
2.14E-01
4.69E-08
6.11E-05
1.62E-04
3.82E-06
8.62E-01
4.28E-19
3.21E-02
ns
8.84E-02
5.71E-10
ns
ns
1.52E-02
9.73E-07
5.38E-04
1.44E-02
1.80E-01
ns
5.14E-05
ns
4.27E-01
5.10E-02
ns
ns
ns
ns
3.11E-05
3.87E-04
ns
ns
ns
7.98E-01
ns
1.25E-02
4.37E-02
1.91E-06
1.28E-04
1.31E-03
4.42E-02
7.13E-01
ns
ns
4.54E-04
ns
9.20E-01
ns
5.46E-01
ns
ns
2.31E-01
ns
2.25E-04
+-?+??-+
-+
-?
?-++
+-?
++
+++
-?
?+
++
++
--?+
-++-+
++-?-?--?
-+
?+-+-?
-+++
?-++
--+
-+-++
+++
---+-+
?+
-?
-++
+--+
?
-+
--?
++
++
+?+
++++
-??+
+++
?+
++
-?++
?+
++?--?+
-++
++?
-+
+??+
-?+
++
?+
-+
--++
++
-+-?-+
+-++
+++++
-?+
++
+++
?+
?++-++
-+++
+-+
?-?
?+
-?+
?++
++
+-
515
515
213
515
213
213
515
515
302
213
515
515
515
302
515
515
515
302
213
515
515
515
515
213
515
515
515
515
515
515
515
213
515
213
515
302
515
213
515
515
515
302
515
515
515
213
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
213
302
515
515
515
515
515
0
515
515
302
515
515
515
213
515
515
515
515
213
213
515
515
213
515
515
213
515
213
515
515
213
515
515
213
515
515
515
302
515
515
213
213
515
213
515
213
515
515
515
515
515
515
515
515
213
515
515
515
515
515
515
515
515
515
213
515
515
515
213
213
515
515
515
515
515
515
515
515
515
213
302
213
515
213
213
515
515
515
-0.261
-5.117
-1.684
1.507
-0.444
-0.580
-0.569
0.546
-1.815
-0.411
-0.539
1.878
-1.043
-1.865
1.749
0.234
2.793
-1.146
2.393
1.282
0.575
-1.090
-3.079
1.955
-2.377
-0.230
-0.638
0.455
0.264
-0.163
-0.665
-2.052
-2.056
-0.450
-1.033
-0.633
0.021
-1.344
-1.041
-1.469
0.118
-2.391
-1.746
-0.780
1.908
-0.851
-0.504
0.716
-3.285
-0.210
-1.355
-1.069
-1.425
5.323
-0.461
3.496
-1.744
-2.079
-1.418
-0.543
1.243
4.295
-0.268
-2.129
0.495
0.582
-2.345
1.425
ns
1.146
-0.960
-1.892
2.873
1.966
-0.029
0.842
-0.389
0.831
4.991
-2.075
-0.185
0.455
0.646
3.548
0.739
1.748
-0.612
-1.480
0.886
3.038
1.199
-0.123
-0.954
-1.776
-1.261
0.111
-1.568
4.879
-0.475
2.395
-0.769
0.063
-2.072
2.037
-0.417
1.183
1.393
0.787
0.855
-5.524
-1.262
1.437
4.336
-1.790
-0.081
-0.869
-1.943
0.350
-0.066
-1.417
2.394
-1.201
0.723
0.003
0.660
-0.259
0.510
0.630
-0.030
1.541
0.986
-1.175
-0.700
-0.485
-1.276
0.889
-1.624
0.425
0.930
0.370
0.319
-0.716
-1.546
0.719
-0.698
3.954
-1.713
0.921
0.784
-0.700
7.94E-01
3.11E-07
9.22E-02
1.32E-01
6.57E-01
5.62E-01
5.70E-01
5.85E-01
6.95E-02
6.81E-01
5.90E-01
6.04E-02
2.97E-01
6.22E-02
8.02E-02
8.15E-01
5.22E-03
2.52E-01
1.67E-02
2.00E-01
5.65E-01
2.76E-01
2.08E-03
5.06E-02
1.75E-02
8.18E-01
5.23E-01
6.49E-01
7.92E-01
8.70E-01
5.06E-01
4.02E-02
3.98E-02
6.53E-01
3.02E-01
5.27E-01
9.83E-01
1.79E-01
2.98E-01
1.42E-01
9.06E-01
1.68E-02
8.08E-02
4.35E-01
5.64E-02
3.95E-01
6.14E-01
4.74E-01
1.02E-03
8.34E-01
1.75E-01
2.85E-01
1.54E-01
1.02E-07
6.45E-01
4.73E-04
8.11E-02
3.76E-02
1.56E-01
5.88E-01
2.14E-01
1.75E-05
7.89E-01
3.33E-02
6.21E-01
5.61E-01
1.90E-02
1.54E-01
ns
2.52E-01
3.37E-01
5.85E-02
4.07E-03
4.93E-02
9.77E-01
4.00E-01
6.98E-01
4.06E-01
6.00E-07
3.80E-02
8.53E-01
6.49E-01
5.18E-01
3.88E-04
4.60E-01
8.05E-02
5.40E-01
1.39E-01
3.76E-01
2.38E-03
2.31E-01
9.03E-01
3.40E-01
7.58E-02
2.07E-01
9.12E-01
1.17E-01
1.06E-06
6.35E-01
1.66E-02
4.42E-01
9.50E-01
3.83E-02
4.16E-02
6.77E-01
2.37E-01
1.64E-01
4.31E-01
3.93E-01
3.32E-08
2.07E-01
1.51E-01
1.45E-05
7.34E-02
9.36E-01
3.85E-01
5.20E-02
7.27E-01
9.47E-01
1.57E-01
1.67E-02
2.30E-01
4.70E-01
9.98E-01
5.09E-01
7.96E-01
6.10E-01
5.29E-01
9.76E-01
1.23E-01
3.24E-01
2.40E-01
4.84E-01
6.28E-01
2.02E-01
3.74E-01
1.04E-01
6.71E-01
3.52E-01
7.11E-01
7.50E-01
4.74E-01
1.22E-01
4.72E-01
4.85E-01
7.70E-05
8.68E-02
3.57E-01
4.33E-01
4.84E-01
?
?
+
+
?
?
+
+
+
+
?
+
+
+
+
?
?
?
?
+
+
+
+
?
?
+
+
?
+
?
?
+
+
?
+
+
?
+
?
+
?
?
+
+
+
+
?
?
?
?
+
+
+
+
+
+
?
+
+
+
+
?
+
+
+
+
?
+
+
+
?
+
?
?
+
+
-
299
299
0
299
0
299
299
299
299
0
0
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
0
299
0
299
299
299
0
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
0
299
299
299
299
299
299
0
299
299
299
299
0
0
299
299
0
299
299
0
299
0
299
299
0
299
299
0
299
299
299
299
299
299
0
0
299
0
299
0
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
0
299
299
299
299
0
299
299
299
299
299
299
299
299
299
0
299
299
299
0
0
299
299
299
-0.012
-0.026
ns
-0.005
ns
0.003
-0.001
-0.017
0.001
ns
ns
0.029
-0.017
-0.011
0.009
0.005
0.025
-0.029
ns
0.022
0.007
-0.003
-0.011
0.009
-0.031
-0.008
-0.007
-0.008
0.006
-0.006
-0.001
ns
-0.016
ns
-0.003
-0.003
-0.020
ns
-0.008
-0.022
-0.003
-0.014
-0.013
-0.007
0.000
ns
-0.011
0.009
-0.015
0.002
-0.037
-0.014
-0.005
0.073
-0.005
0.021
-0.008
-0.010
-0.004
-0.004
-0.001
ns
-0.006
-0.007
-0.025
-0.004
-0.019
-0.011
ns
0.013
-0.012
-0.018
0.024
-0.006
-0.018
ns
-0.003
-0.013
0.019
-0.012
ns
ns
0.020
0.039
ns
0.003
0.014
ns
0.004
ns
0.014
-0.027
ns
-0.007
-0.005
ns
-0.013
0.012
0.001
0.019
-0.023
0.023
ns
ns
-0.014
ns
-0.011
ns
0.017
0.003
0.002
-0.009
0.014
-0.012
0.003
0.007
ns
-0.015
-0.004
-0.035
0.012
0.003
0.002
-0.017
0.020
-0.027
ns
0.004
0.001
0.012
0.000
ns
-0.009
-0.009
-0.003
0.012
-0.010
-0.005
0.014
0.003
-0.008
ns
-0.017
0.004
-0.022
ns
ns
0.007
0.004
-0.008
0.007
0.004
ns
0.006
ns
0.002
0.004
0.006
0.002
ns
ns
0.005
0.009
0.006
0.003
0.003
0.008
0.006
ns
0.007
0.006
0.004
0.003
0.002
0.006
0.005
0.005
0.003
0.011
0.006
0.006
ns
0.004
ns
0.004
0.002
0.005
ns
0.005
0.009
0.003
0.003
0.004
0.004
0.006
ns
0.005
0.003
0.007
0.002
0.006
0.004
0.002
0.014
0.006
0.008
0.007
0.003
0.006
0.005
0.002
ns
0.004
0.005
0.007
0.006
0.004
0.006
ns
0.005
0.005
0.003
0.006
0.006
0.007
ns
0.005
0.005
0.005
0.003
ns
ns
0.008
0.014
ns
0.003
0.005
ns
0.004
ns
0.005
0.010
ns
0.003
0.002
ns
0.005
0.005
0.009
0.007
0.005
0.007
ns
ns
0.005
ns
0.006
ns
0.012
0.003
0.004
0.006
0.005
0.004
0.003
0.010
ns
0.007
0.005
0.008
0.006
0.002
0.005
0.006
0.009
0.006
ns
0.002
0.003
0.004
0.002
ns
0.004
0.003
0.006
0.005
0.006
0.003
0.007
0.004
0.007
ns
0.004
0.004
0.007
ns
ns
0.004
0.002
0.004
6.20E-02
1.39E-08
ns
4.03E-01
ns
1.19E-01
8.46E-01
2.45E-03
5.33E-01
ns
ns
6.80E-09
6.78E-02
6.27E-02
6.66E-03
1.36E-01
1.22E-03
4.37E-07
ns
1.17E-03
2.56E-01
5.46E-01
1.63E-04
1.88E-04
6.79E-07
8.50E-02
1.39E-01
1.41E-02
5.80E-01
3.01E-01
9.21E-01
ns
4.05E-04
ns
4.52E-01
2.01E-01
2.75E-05
ns
1.00E-01
1.33E-02
2.79E-01
2.17E-07
4.57E-03
1.03E-01
9.95E-01
ns
3.61E-02
1.33E-03
2.82E-02
5.18E-01
2.58E-09
3.34E-04
3.16E-02
2.08E-07
3.72E-01
1.17E-02
2.47E-01
2.12E-03
4.21E-01
4.15E-01
8.29E-01
ns
1.24E-01
2.14E-01
5.02E-04
5.15E-01
1.99E-05
4.51E-02
ns
4.17E-03
1.65E-02
8.66E-09
2.73E-05
2.95E-01
1.28E-02
ns
5.44E-01
9.08E-03
1.06E-04
4.82E-06
ns
ns
1.13E-02
4.99E-03
ns
2.27E-01
2.88E-03
ns
3.04E-01
ns
9.75E-03
8.79E-03
ns
4.88E-03
1.32E-02
ns
1.93E-02
8.55E-03
9.19E-01
3.85E-03
8.43E-06
1.08E-03
ns
ns
1.65E-03
ns
8.10E-02
ns
1.32E-01
2.99E-01
5.38E-01
1.56E-01
5.36E-03
1.21E-03
1.89E-01
5.15E-01
ns
2.99E-02
4.38E-01
3.66E-05
6.84E-02
1.47E-01
7.29E-01
6.85E-03
2.65E-02
3.68E-05
ns
9.65E-02
7.87E-01
7.77E-04
8.38E-01
ns
2.66E-02
3.93E-03
6.05E-01
7.14E-03
9.31E-02
1.19E-01
4.14E-02
5.13E-01
2.67E-01
ns
1.65E-05
2.68E-01
3.66E-03
ns
ns
8.19E-02
7.71E-02
4.72E-02
--+-+
+++
++
+?
?+
++
+?
-+
-?+
-+
-+
-+
?+-+
++
--?
++
---+
+?
-+
++
-+
+?
-?
-?
+?+
++
++
+-+
-+
?
---+
-+++
-+
++
++
--+-++
-+
---+
++
++
?
-+
++
--++
?+
++
-?+
-+
+-+-+
++
++
-+
+?
-?
-+
++
-+
-+
-+
--+
++
-+
-+
+---+
-+-?++
-+
-++-+
+++
++
--+
-++
-++
-+
++
+-+
-+
++
--+
-+
++
-?
+?
-+
-+
-+-+
---+
+-+
-+-+
+-+
?
-+
-+
-+
-+
++
++
-?
567
567
567
567
567
567
567
213
354
567
213
567
567
354
567
567
567
354
567
567
567
567
213
567
567
567
567
213
567
567
567
213
213
213
567
354
567
567
567
567
567
0
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
0
567
567
567
567
567
354
567
567
354
567
567
567
567
567
567
567
567
213
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
0
567
567
567
567
567
567
213
-3.519
-2.204
1.084
0.226
0.603
1.445
4.736
0.580
0.145
1.976
2.076
1.309
-0.642
1.811
-0.508
-0.542
0.167
-4.345
1.086
0.272
3.054
-1.737
-0.278
2.728
-2.177
-2.639
0.886
1.163
2.564
1.234
1.252
0.925
-2.080
-1.680
-1.281
1.794
1.292
3.405
-1.920
-1.333
-0.115
ns
-2.365
-3.404
1.325
-4.202
-1.385
1.336
0.707
2.737
0.455
-2.634
-1.279
0.171
-5.462
0.895
-0.308
-2.081
-3.273
-1.348
0.620
1.464
ns
-0.678
1.563
-1.858
-1.980
1.820
3.470
2.810
-1.988
2.099
1.476
-2.474
-2.595
0.119
-0.103
2.141
1.920
0.133
0.630
-1.229
-0.237
2.064
-0.331
2.714
-0.128
-3.843
0.195
2.899
2.029
-1.065
-0.651
-4.345
-3.595
-0.942
-1.232
0.966
-2.150
-0.415
1.207
0.892
-3.064
1.153
-1.019
0.595
-2.250
2.512
0.945
-3.585
0.931
-1.204
0.389
-3.025
0.883
0.844
1.749
0.453
-0.224
0.414
3.328
-1.474
0.304
-0.525
0.801
-1.841
1.447
1.642
-0.390
-0.580
1.844
-0.707
-3.875
-2.698
1.029
-0.655
0.414
-1.813
0.067
2.177
-2.081
-0.722
ns
0.524
-0.235
-0.156
-0.682
1.015
3.052
-1.080
4.33E-04
2.75E-02
2.79E-01
8.22E-01
5.47E-01
1.49E-01
2.18E-06
5.62E-01
8.85E-01
4.81E-02
3.79E-02
1.91E-01
5.21E-01
7.01E-02
6.11E-01
5.88E-01
8.67E-01
1.39E-05
2.78E-01
7.86E-01
2.26E-03
8.25E-02
7.81E-01
6.37E-03
2.95E-02
8.31E-03
3.76E-01
2.45E-01
1.03E-02
2.17E-01
2.11E-01
3.55E-01
3.75E-02
9.29E-02
2.00E-01
7.28E-02
1.96E-01
6.61E-04
5.49E-02
1.82E-01
9.09E-01
ns
1.80E-02
6.64E-04
1.85E-01
2.64E-05
1.66E-01
1.81E-01
4.79E-01
6.20E-03
6.49E-01
8.43E-03
2.01E-01
8.64E-01
4.72E-08
3.71E-01
7.58E-01
3.74E-02
1.07E-03
1.78E-01
5.36E-01
1.43E-01
ns
4.98E-01
1.18E-01
6.31E-02
4.77E-02
6.88E-02
5.21E-04
4.95E-03
4.68E-02
3.58E-02
1.40E-01
1.34E-02
9.45E-03
9.06E-01
9.18E-01
3.23E-02
5.49E-02
8.94E-01
5.29E-01
2.19E-01
8.13E-01
3.90E-02
7.41E-01
6.65E-03
8.98E-01
1.22E-04
8.46E-01
3.74E-03
4.25E-02
2.87E-01
5.15E-01
1.39E-05
3.25E-04
3.46E-01
2.18E-01
3.34E-01
3.16E-02
6.78E-01
2.27E-01
3.73E-01
2.18E-03
2.49E-01
3.08E-01
5.52E-01
2.45E-02
1.20E-02
3.45E-01
3.37E-04
3.52E-01
2.29E-01
6.97E-01
2.49E-03
3.77E-01
3.99E-01
8.03E-02
6.50E-01
8.23E-01
6.79E-01
8.75E-04
1.40E-01
7.61E-01
6.00E-01
4.23E-01
6.56E-02
1.48E-01
1.01E-01
6.96E-01
5.62E-01
6.52E-02
4.79E-01
1.07E-04
6.98E-03
3.04E-01
5.13E-01
6.79E-01
6.98E-02
9.47E-01
2.95E-02
3.74E-02
4.70E-01
ns
6.00E-01
8.15E-01
8.76E-01
4.95E-01
3.10E-01
2.27E-03
2.80E-01
+
+
+
+
+
+
+
?
+
?
?
+
?
+
?
?
+
+
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
?
?
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
+
+
+
+
-
869
869
869
869
869
869
869
869
869
869
0
869
869
0
869
869
869
0
869
869
0
869
869
869
869
869
869
0
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
0.004
0.000
0.002
0.004
0.001
0.004
0.000
0.002
-0.006
-0.002
ns
-0.002
0.000
ns
-0.001
-0.001
-0.001
ns
0.004
0.000
ns
-0.001
-0.002
-0.002
0.002
0.000
-0.001
ns
-0.004
ns
-0.001
-0.001
0.004
0.001
0.006
-0.001
0.002
0.000
ns
-0.005
0.003
0.001
0.000
0.004
0.005
0.000
0.000
-0.001
-0.001
0.002
-0.001
0.003
0.005
0.008
0.001
-0.001
0.004
0.003
-0.001
0.002
0.000
0.001
ns
0.003
-0.004
0.006
-0.002
-0.001
-0.001
0.003
0.000
-0.007
0.001
0.000
0.001
0.000
0.000
0.000
0.000
-0.002
-0.001
ns
-0.001
ns
-0.006
-0.005
-0.007
0.002
0.002
0.004
0.004
-0.003
0.000
0.000
0.002
-0.002
0.002
0.000
0.000
ns
0.005
-0.002
-0.002
-0.001
0.005
0.000
-0.003
0.002
0.000
-0.002
-0.002
0.000
0.001
0.004
ns
-0.005
-0.001
-0.002
0.002
0.009
-0.001
0.002
0.000
0.002
0.002
-0.001
0.001
0.001
0.005
0.003
0.000
-0.002
0.001
0.003
0.003
-0.001
-0.002
0.002
ns
0.001
0.003
0.004
-0.001
0.000
-0.003
-0.001
0.001
0.002
0.002
-0.002
0.001
0.001
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.002
ns
0.001
0.002
ns
0.001
0.001
0.001
ns
0.001
0.000
ns
0.001
0.001
0.002
0.001
0.001
0.001
ns
0.001
ns
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
ns
0.002
0.001
0.000
0.001
0.001
0.002
0.001
0.000
0.001
0.004
0.002
0.001
0.001
0.002
0.003
0.001
0.002
0.002
0.001
0.001
0.001
0.003
0.002
ns
0.001
0.002
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.000
0.001
0.001
0.001
0.002
0.001
ns
0.002
ns
0.002
0.002
0.002
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
ns
0.002
0.002
0.002
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.003
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
4.28E-04
7.91E-01
2.60E-02
2.28E-05
3.85E-01
2.36E-01
5.79E-01
1.13E-03
6.00E-06
3.12E-01
ns
1.72E-01
9.38E-01
ns
3.27E-01
5.93E-01
6.04E-01
ns
1.54E-04
5.87E-01
ns
5.20E-01
2.04E-01
2.09E-01
4.14E-02
6.83E-01
2.57E-01
ns
9.95E-04
ns
5.00E-01
7.07E-02
7.85E-03
2.92E-01
2.69E-04
5.97E-01
9.20E-04
8.92E-01
ns
3.43E-02
3.32E-03
4.31E-03
5.76E-01
1.60E-03
1.17E-02
6.93E-01
9.25E-01
5.73E-02
7.44E-01
4.71E-01
3.82E-01
5.00E-03
5.47E-03
1.09E-02
3.71E-01
6.73E-01
1.81E-02
1.96E-03
6.42E-01
1.59E-01
9.09E-01
5.79E-01
ns
7.19E-03
1.07E-01
3.24E-07
1.53E-02
2.91E-01
3.82E-01
1.25E-01
6.82E-01
9.80E-07
1.63E-01
6.40E-01
6.51E-01
5.38E-01
7.93E-01
8.65E-01
5.28E-01
2.69E-01
2.12E-01
ns
7.92E-01
ns
7.46E-03
7.57E-03
2.02E-04
1.47E-02
4.50E-02
1.05E-01
6.05E-10
2.94E-02
7.11E-01
8.00E-01
2.24E-01
1.67E-02
9.93E-02
6.17E-01
6.62E-01
ns
6.15E-03
1.30E-01
1.62E-02
8.19E-02
1.49E-06
6.82E-01
8.13E-04
2.90E-03
8.76E-01
1.26E-01
2.09E-02
7.73E-01
7.72E-02
6.49E-03
ns
9.79E-03
7.16E-01
2.43E-01
8.76E-02
1.32E-05
3.64E-01
6.71E-02
8.40E-01
6.28E-02
3.57E-02
2.55E-01
6.43E-01
4.40E-01
7.42E-05
7.71E-04
3.94E-01
6.28E-02
2.55E-01
3.88E-04
4.43E-04
3.65E-01
6.50E-02
9.88E-03
ns
1.28E-01
1.96E-04
2.99E-03
4.74E-01
4.98E-01
2.48E-03
3.36E-01
4.64E-01
2.16E-01
5.02E-01
1.94E-01
?
?
?
?
?
?
+
+
?
?
?
?
+
?
?
?
+
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
+
+
?
?
?
?
?
+
?
?
?
?
?
?
?
+
?
?
?
?
+
?
?
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
?
?
+
?
+
+
?
?
+
?
?
?
?
?
+
?
+
?
+
?
?
+
?
0
0
0
1244
1244
0
0
1244
0
1244
1244
0
0
0
0
1244
0
0
0
1244
0
0
0
1244
1244
1244
0
0
0
1244
0
0
1244
0
0
0
1244
1244
0
0
1244
0
0
0
0
0
0
0
1244
1244
1244
0
1244
0
0
0
0
1244
0
1244
1244
1244
1244
0
0
1244
0
0
0
1244
1244
0
0
1244
1244
0
0
0
0
1244
1244
0
1244
0
0
0
0
1244
0
0
0
0
0
0
0
1244
0
0
0
0
0
1244
0
0
1244
0
0
0
0
0
0
0
0
0
1244
0
0
1244
0
0
0
0
1244
0
1244
0
1244
1244
0
0
1244
1244
0
0
0
0
1244
0
1244
0
1244
1244
0
1244
1244
1244
0
0
1244
0
ns
ns
ns
-0.001
-0.001
ns
ns
-0.003
ns
0.001
0.000
ns
ns
ns
ns
0.001
ns
ns
ns
0.001
ns
ns
ns
0.001
-0.003
-0.002
ns
ns
ns
-0.001
ns
ns
-0.001
ns
ns
ns
-0.001
-0.001
ns
ns
-0.001
ns
ns
ns
ns
ns
ns
ns
0.000
-0.003
-0.002
ns
-0.001
ns
ns
ns
ns
-0.001
ns
0.000
0.001
0.003
-0.002
ns
ns
-0.002
ns
ns
ns
0.003
-0.001
ns
ns
0.000
-0.001
ns
ns
ns
ns
-0.002
-0.001
ns
0.000
ns
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
0.000
ns
ns
ns
ns
ns
0.000
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.002
ns
ns
0.000
ns
ns
ns
ns
-0.001
ns
0.003
ns
0.001
0.000
ns
ns
0.006
0.000
ns
ns
ns
ns
-0.002
ns
0.001
ns
-0.001
0.001
ns
0.000
-0.002
0.001
ns
ns
0.002
ns
ns
ns
ns
0.000
0.000
ns
ns
0.000
ns
0.000
0.000
ns
ns
ns
ns
0.000
ns
ns
ns
0.001
ns
ns
ns
0.000
0.001
0.000
ns
ns
ns
0.000
ns
ns
0.000
ns
ns
ns
0.000
0.000
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
0.000
0.000
0.001
ns
0.000
ns
ns
ns
ns
0.000
ns
0.000
0.000
0.000
0.000
ns
ns
0.000
ns
ns
ns
0.001
0.000
ns
ns
0.001
0.000
ns
ns
ns
ns
0.000
0.000
ns
0.001
ns
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
0.000
ns
ns
ns
ns
ns
0.000
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.001
ns
ns
0.000
ns
ns
ns
ns
0.000
ns
0.001
ns
0.000
0.000
ns
ns
0.002
0.000
ns
ns
ns
ns
0.001
ns
0.000
ns
0.000
0.001
ns
0.000
0.001
0.000
ns
ns
0.000
ns
ns
ns
ns
2.89E-02
7.17E-03
ns
ns
1.31E-12
ns
1.66E-03
6.70E-01
ns
ns
ns
ns
1.21E-04
ns
ns
ns
4.34E-02
ns
ns
ns
6.45E-06
2.40E-07
1.97E-07
ns
ns
ns
6.00E-02
ns
ns
1.15E-05
ns
ns
ns
3.58E-03
4.60E-03
ns
ns
2.23E-03
ns
ns
ns
ns
ns
ns
ns
8.33E-01
1.07E-20
6.69E-06
ns
4.46E-06
ns
ns
ns
ns
2.60E-05
ns
6.07E-01
1.49E-02
7.11E-14
2.60E-17
ns
ns
2.10E-04
ns
ns
ns
1.87E-07
1.08E-02
ns
ns
4.01E-01
1.16E-03
ns
ns
ns
ns
1.65E-08
2.28E-02
ns
7.26E-01
ns
ns
ns
ns
9.44E-01
ns
ns
ns
ns
ns
ns
ns
3.78E-01
ns
ns
ns
ns
ns
8.92E-01
ns
ns
3.68E-01
ns
ns
ns
ns
ns
ns
ns
ns
ns
6.03E-04
ns
ns
3.04E-01
ns
ns
ns
ns
6.59E-02
ns
7.84E-09
ns
4.17E-03
1.07E-02
ns
ns
1.20E-04
5.30E-02
ns
ns
ns
ns
3.49E-03
ns
2.91E-03
ns
3.25E-03
2.75E-01
ns
1.64E-01
1.18E-03
1.49E-01
ns
ns
2.27E-05
ns
-+
-+-+
--?
++
-+?
++
-?
++
-+
-?
++
+++
-?
+?
++-++-+
---?
++
-+
-+?
--+-?
+-+
-+
-+
---+
-+-+
-??
+-?
-+
-+
-?
+?
-?
++
++
-+
++
-+
++-?
-+
-+
--+
+-?
++
-+
--+
-+
-+-+
-++
++
-+
-?
+++?
-+++++
++
-+
-+-++
--?
-+?
+?
+--?
-+?
-+
-+?
+++
--+
-+?
--+
-?
-+
-+
0+
+--+-+
+?
-+
-+++
-+
-+
+-+
++
-+
++
+?
++
++
+-+?
-+-+
++?
-+
362
362
362
362
362
134
362
362
134
362
134
362
362
134
362
362
362
134
134
362
362
362
362
362
362
362
362
134
362
362
362
134
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
134
362
362
134
134
134
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
134
362
134
134
362
362
134
362
134
362
362
134
362
362
362
362
362
134
362
362
134
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
134
362
362
362
362
134
362
0.244
-1.014
-0.487
-0.763
-1.981
-0.787
1.798
-3.370
0.187
0.493
-0.999
0.428
0.396
-1.052
0.321
-0.696
0.809
-0.750
0.097
-0.823
-1.135
-0.919
0.281
-0.842
-0.938
-2.048
-3.153
-2.382
1.763
0.466
-3.545
0.157
-1.249
-2.041
-0.289
-1.499
-2.516
-0.516
0.495
-0.144
-1.398
-1.991
-0.528
-1.689
0.103
0.076
-2.679
0.000
-0.704
-1.168
-0.353
-0.553
-1.882
0.229
-2.186
2.744
0.840
-1.069
1.862
-0.438
-0.752
-0.201
-1.542
-1.042
-0.450
-1.225
0.847
-1.169
-2.457
0.308
-0.008
-2.898
1.662
-0.457
-2.322
-1.309
0.778
-3.243
2.264
0.254
-0.036
-1.177
-0.745
0.020
0.123
-0.941
-0.279
-1.046
-0.588
0.867
1.289
-1.005
-2.556
-0.023
-2.644
1.404
-1.880
-1.039
-2.248
0.044
0.309
-0.623
-2.864
-0.919
-0.788
0.044
0.056
-2.626
0.054
-0.712
0.734
-1.155
1.032
-2.729
0.066
-2.099
0.009
-1.041
-0.688
0.026
1.022
-0.518
-1.618
-3.815
-0.440
0.281
0.464
0.191
-1.209
-0.297
1.408
0.018
0.838
0.006
1.075
1.770
-0.595
2.168
0.004
0.670
0.380
-0.362
-1.493
0.078
-2.880
-0.172
0.042
-0.172
0.014
0.548
8.07E-01
3.10E-01
6.26E-01
4.46E-01
4.76E-02
4.31E-01
7.22E-02
7.52E-04
8.52E-01
6.22E-01
3.18E-01
6.69E-01
6.92E-01
2.93E-01
7.48E-01
4.87E-01
4.19E-01
4.53E-01
9.23E-01
4.10E-01
2.57E-01
3.58E-01
7.79E-01
4.00E-01
3.48E-01
4.06E-02
1.62E-03
1.72E-02
7.79E-02
6.41E-01
3.92E-04
8.75E-01
2.12E-01
4.13E-02
7.73E-01
1.34E-01
1.19E-02
6.06E-01
6.20E-01
8.85E-01
1.62E-01
4.65E-02
5.97E-01
9.13E-02
9.18E-01
9.40E-01
7.40E-03
1.00E+00
4.81E-01
2.43E-01
7.24E-01
5.80E-01
5.99E-02
8.19E-01
2.88E-02
6.08E-03
4.01E-01
2.85E-01
6.26E-02
6.62E-01
4.52E-01
8.41E-01
1.23E-01
2.97E-01
6.53E-01
2.21E-01
3.97E-01
2.43E-01
1.40E-02
7.58E-01
9.94E-01
3.75E-03
9.66E-02
6.48E-01
2.02E-02
1.91E-01
4.37E-01
1.18E-03
2.36E-02
8.00E-01
9.72E-01
2.39E-01
4.57E-01
9.84E-01
9.02E-01
3.47E-01
7.80E-01
2.96E-01
5.57E-01
3.86E-01
1.98E-01
3.15E-01
1.06E-02
9.82E-01
8.21E-03
1.60E-01
6.01E-02
2.99E-01
2.46E-02
9.65E-01
7.57E-01
5.34E-01
4.18E-03
3.58E-01
4.31E-01
9.65E-01
9.56E-01
8.63E-03
9.57E-01
4.77E-01
4.63E-01
2.48E-01
3.02E-01
6.35E-03
9.47E-01
3.58E-02
9.93E-01
2.98E-01
4.91E-01
9.80E-01
3.07E-01
6.04E-01
1.06E-01
1.36E-04
6.60E-01
7.79E-01
6.43E-01
8.49E-01
2.27E-01
7.67E-01
1.59E-01
9.86E-01
4.02E-01
9.95E-01
2.83E-01
7.68E-02
5.52E-01
3.02E-02
9.97E-01
5.03E-01
7.04E-01
7.17E-01
1.36E-01
9.38E-01
3.97E-03
8.63E-01
9.67E-01
8.64E-01
9.89E-01
5.84E-01
39957
30474
37947
26694
13912
59911
54471
37270
48180
61156
57488
44621
45386
48698
27340
67416
13306
26087
46903
14589
46089
45609
19603
52521
22540
7043
34722
8881
64427
7104
20613
31227
3620
22120
5015
17818
36592
316
32157
33239
2899
5195
13231
48839
5426
36098
44427
48791
23624
14294
35139
17226
17055
57771
11610
20217
15462
7476
11886
41939
22588
28986
23811
48013
15325
39444
24604
20721
61814
10485
14343
32940
36113
60474
54141
31706
32401
21023
60717
7166
89
38642
33737
20746
35333
26712
67920
21505
67511
20436
34083
52271
13521
42381
27749
19718
30550
31886
53317
34255
16381
52340
1297
42372
60804
17417
45634
62985
35238
36538
24611
35007
59124
16485
47882
63490
1355
47088
6683
3437
5599
58853
33973
29964
53465
51666
23129
17631
50859
52381
62049
34481
42260
58636
48641
24452
25113
23264
34914
17484
13574
39281
31495
64849
35254
62279
35886
393
67597
1389
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
4282
1912
9960
9446
2268
23658
6925
55250
5050
10161
4841
2802
27040
2306
57820
8237
79931
30844
197370
124221
51379
8671
84154
29914
7414
5527
54940
147694
3594
4092
51134
26262
231
1465
307
9961
1050
9836
25902
10227
80727
5208
9046
6124
9746
57823
11222
6947
10449
5026
25780
5636
145864
1845
4670
8664
152789
11031
50852
84319
55692
9188
1788
79752
84230
51316
977
5243
6512
831
8879
326624
79590
3398
91937
10875
79037
23127
23569
29107
79161
26509
8837
1847
51337
53637
976
2162
54955
124222
138151
58473
64949
1933
55133
57007
3932
22929
29121
7174
353
1992
169714
91404
1729
5873
55031
9984
79871
439921
79090
27436
126231
6596
152485
64764
5329
24141
10240
25816
3683
353514
2288
6916
84986
57128
23191
84925
8714
28387
274
27350
26053
10632
80762
3684
2992
1731
1808
25873
6297
921
128178
6868
8187
5001
28973
10574
91574
2956
MIF
PHC2
USP3
GSTO1
FGR
LSM5
TCF4
ELP2
PAFAH1B3
LPAR6
NONO
GOLGA3
LAT
FOXD2
CCNB1IP1
USP11
TNIP3
EHD4
NSMCE1
PRSS30P
CRLF3
SLC4A4
RPF2
UBIAD1
VCL
PPP2R5C
OCIAD1
ZNF548
IL12RB1
SMAD7
CCDC41
TSPAN17
AKR1B1
CSRP1
ANXA4
MVP
CEBPA
LCMT2
MTHFD1L
MFSD10
TTYH3
PFKFB2
DOK2
RPL4
CLSTN3
SLAMF7
MRPL3
TCN1
ACAA2
P2RX5
RASGRP3
PRPSAP2
HAPLN3
DUSP3
HNRNPM
EIF3D
JAKMIP1
RAB31
TRAT1
CMSS1
LUC7L
DDX21
DNMT3A
ZFAND1
LRRC8C
PLAC8
CD151
ABCB1
SLC1A7
CAST
SGPL1
RAB37
MRPL24
ID2
TIMD4
FGL2
PVRIG
GLT25D2
PADI4
NXT1
C7orf23
MYOF
CFLAR
DUSP5
THEM6
S1PR5
CD97
F13A1
C1orf109
PAQR4
NACC2
PLEKHB1
MRPS26
EEF1B2
SRBD1
CXCR7
LCK
SEPHS1
CLEC2D
TPP2
APRT
SERPINB1
QSOX2
SESTD1
DIAPH1
RAB27A
USP47
THOC1
RPAP2
MXRA7
TRAPPC6A
EML4
ZNF573
HLTF
ZNF827
CREB3L2
PLAUR
LAMP5
MRPS31
TNFAIP8
ITGAL
LILRA5
FKBP4
TBXAS1
ARHGAP19
LYRM4
CYFIP1
DIRC2
ABCC3
IGHV5-78
BIN1
APOBEC3C
AUTS2
ATP5L
NDFIP1
ITGAM
GYG1
SEPT1
DPYSL2
RPL36
SALL2
CD5
EDARADD
ADAM17
ZNF239
ORC5
MRPS18B
CCT7
C12orf65
MSH6
-----++++++
++++++
++++++
++++++
------+-------------+
+++++---------------++++++
----------+++-++
++-+++
-----++++++
--+--++++++
----------++-+++
++++++
--+-------++-+++
++-+++
-----++-+++
-----+
++-+++
+++?++
++++++
++++++
----------++-+++
++++++
++++++
++++++
-----++-+++
++-+-+
---?-++++++
++++-+
----+-+-------------++++++
----------+
+-++++
++++++
----+---+-----------------------------+-++++++
-----++++++
++++++
++++++
++++++
-----++-+++
-----++++++
-----++++++
-+++-+
-----+
-----++-+++
++++++
++-+++
-----+
++-++++++++
++++++
-----++++++
++++++
---------------++++++
--------?---------------------+-++++
-----+++?++
++-+++
++++++
---------------++++++
-----+---------------+---++-+++
++++++
--+------------++-+++
++++++
-----++++++
++++++
-----++++++
+-++++
++--++
----------++-+++
-------+----+--++++-+
++++++
-----+-++++
-----+
-----+
-----++--++
+++--+
---+----------------+
-----------
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-6.097
6.867
6.190
8.361
7.112
-7.772
-5.100
-8.818
-5.321
4.993
-5.811
-7.342
-7.167
8.042
-7.934
-6.645
6.977
7.063
-5.151
7.820
-7.622
5.498
-6.879
-5.049
7.320
7.259
-6.419
-7.926
6.798
9.165
-7.778
7.816
-5.879
6.838
7.764
6.022
5.925
-7.127
-5.977
8.255
7.064
6.758
7.256
-8.060
5.359
6.371
-7.395
8.567
7.294
-8.195
-6.880
-7.482
-7.003
8.734
-6.736
-6.714
5.442
6.723
-7.556
-8.436
-7.133
-6.972
-6.910
-7.815
-6.712
-5.914
7.361
-6.485
8.353
7.623
6.962
8.448
-6.528
8.866
-6.563
8.052
-7.282
6.026
8.128
-6.172
-8.212
6.392
6.318
8.078
-5.324
7.961
6.842
8.169
-5.212
7.466
7.728
-6.307
-4.920
-7.726
6.849
-6.601
-8.404
-6.746
-8.079
-6.946
-6.179
6.931
-6.090
6.215
5.933
7.669
-6.849
-5.829
-7.505
7.275
-5.705
-8.660
-7.909
-6.525
-5.204
5.642
7.335
-5.535
-7.068
-7.133
5.652
8.642
-5.966
5.577
6.884
-6.565
8.500
8.120
7.146
-6.832
-7.083
5.153
-5.971
-5.849
-6.496
7.881
8.082
-7.481
7.462
-6.622
-6.278
-7.764
6.241
6.997
-6.638
-7.179
-5.338
-6.240
-7.001
-6.642
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.08E-09
6.53E-12
6.03E-10
6.20E-17
1.15E-12
7.72E-15
3.39E-07
1.16E-18
1.04E-07
5.94E-07
6.22E-09
2.11E-13
7.69E-13
8.85E-16
2.12E-15
3.04E-11
3.01E-12
1.62E-12
2.58E-07
5.28E-15
2.51E-14
3.83E-08
6.01E-12
4.44E-07
2.48E-13
3.90E-13
1.38E-10
2.27E-15
1.06E-11
4.94E-20
7.35E-15
5.46E-15
4.13E-09
8.04E-12
8.21E-15
1.72E-09
3.11E-09
1.02E-12
2.27E-09
1.52E-16
1.61E-12
1.40E-11
3.98E-13
7.63E-16
8.36E-08
1.88E-10
1.41E-13
1.07E-17
3.00E-13
2.51E-16
5.97E-12
7.30E-14
2.51E-12
2.45E-18
1.63E-11
1.89E-11
5.26E-08
1.79E-11
4.17E-14
3.30E-17
9.80E-13
3.13E-12
4.84E-12
5.52E-15
1.92E-11
3.34E-09
1.83E-13
8.87E-11
6.68E-17
2.47E-14
3.35E-12
2.96E-17
6.65E-11
7.58E-19
5.29E-11
8.12E-16
3.28E-13
1.68E-09
4.38E-16
6.72E-10
2.17E-16
1.63E-10
2.64E-10
6.60E-16
1.02E-07
1.70E-15
7.83E-12
3.11E-16
1.87E-07
8.26E-14
1.09E-14
2.85E-10
8.64E-07
1.11E-14
7.44E-12
4.07E-11
4.32E-17
1.52E-11
6.52E-16
3.75E-12
6.45E-10
4.18E-12
1.13E-09
5.13E-10
2.98E-09
1.74E-14
7.43E-12
5.57E-09
6.14E-14
3.48E-13
1.16E-08
4.74E-18
2.60E-15
6.82E-11
1.95E-07
1.68E-08
2.21E-13
3.12E-08
1.57E-12
9.81E-13
1.59E-08
5.53E-18
2.43E-09
2.44E-08
5.80E-12
5.20E-11
1.90E-17
4.67E-16
8.96E-13
8.40E-12
1.41E-12
2.56E-07
2.36E-09
4.95E-09
8.26E-11
3.25E-15
6.39E-16
7.37E-14
8.54E-14
3.55E-11
3.42E-10
8.20E-15
4.34E-10
2.62E-12
3.17E-11
7.03E-13
9.41E-08
4.37E-10
2.53E-12
3.09E-11
-------++++++-+
++++++++
-++++-++
++++++++
------------+---------------++++--++
--------------------+++++++++
--+-+-------+--++++?-+
+++++-++
-------++++++++
-------++++++++
--+-------+----+-+++++
++++-+++
--------------+++-++++
++++++++
+-+--+-++++++++
-------++++++++
++-?-??+
++++-+++
++++++++
----------+---++-+++++
--++++++
+++-?-++
+-++++++
--------+++++++
+++-++++
--+----++++++++
+-+++-++
-+---?--+-------------------+++-++++
---------------+++--++
++++++++
-+--------+--------+------------++-----------------+----+++++-++
-+-----+++-++++
+-+++-++
++++++++
-+++++++
--------++-++++
?--????+++++-++
----+--+++-+-++
+++-++-+
--------------++++++++
+++-++++
-+++++++
-------+++-+++++++-+++
++++++-+
-+-----++++++++
++++++++
-----+----------------+++++-+
-------?---???--------------+
-++-----------++++++++
-+------++--+++
++-+++++
-++--+++
-----+---------------++++++++
---++-------------++--+---------++--+++++++
++++++-+
-----+---+-----+-----++++++++
++++++++
---+---++++++++
++++++-+
---+---+++++--+
+++-++-+
++++++++
-+-+----------++++++++
---------------------++++++++
++++++++
---+-+-?
+++++-++
---+--------++---+---+
+++++-++
--++++-+
-----------+-----+----+--------+------+----
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
7782
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
7888
8009
8009
8009
8009
8009
8009
8009
7782
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
4883
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5242
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
4829
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
-7.39
6.64
7.28
5.21
6.40
-5.77
-8.31
-4.77
-8.10
8.41
-7.63
-6.17
-6.33
5.49
-5.59
-6.81
6.48
6.39
-8.21
5.66
-5.84
7.86
-6.54
-8.28
6.11
6.17
-6.95
-5.52
6.59
4.33
-5.65
5.61
-7.45
6.53
5.56
7.29
7.38
-6.22
-7.31
5.13
6.26
6.54
6.06
-5.30
7.85
6.89
-5.97
4.79
5.99
-5.10
-6.37
-5.80
-6.24
4.59
-6.48
-6.50
7.71
6.48
-5.68
-4.84
-6.08
-6.22
-6.28
-5.42
-6.46
-7.22
5.84
-6.67
4.89
5.58
6.21
4.78
-6.61
4.37
-6.63
5.15
-5.87
7.06
5.06
-6.92
-4.97
6.69
6.76
5.06
-7.68
5.17
6.23
4.96
-7.77
5.62
5.36
-6.70
-8.01
-5.34
6.18
-6.41
-4.40
-6.25
-4.98
-6.05
-6.77
6.05
-6.84
6.72
6.97
5.29
-6.06
-7.03
-5.43
5.64
-7.12
-4.30
-5.00
-6.31
-7.56
7.14
5.53
-7.24
-5.78
-5.71
7.12
4.27
-6.82
7.19
5.94
-6.24
4.40
4.76
5.68
-5.98
-5.74
7.57
-6.78
-6.90
-6.28
4.96
4.77
-5.10
5.35
-6.14
-6.47
-5.04
6.49
5.76
-6.10
-5.58
-7.32
-6.46
-5.73
-6.06
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.47E-13
3.17E-11
3.38E-13
1.89E-07
1.56E-10
7.95E-09
9.50E-17
1.84E-06
5.50E-16
4.21E-17
2.40E-14
6.95E-10
2.51E-10
4.04E-08
2.33E-08
9.68E-12
9.29E-11
1.64E-10
2.27E-16
1.50E-08
5.13E-09
3.83E-15
5.99E-11
1.20E-16
1.01E-09
7.07E-10
3.54E-12
3.43E-08
4.40E-11
1.49E-05
1.62E-08
2.02E-08
9.53E-14
6.42E-11
2.72E-08
3.01E-13
1.54E-13
5.13E-10
2.76E-13
2.86E-07
3.95E-10
6.16E-11
1.32E-09
1.19E-07
4.05E-15
5.59E-12
2.34E-09
1.63E-06
2.07E-09
3.36E-07
1.84E-10
6.61E-09
4.30E-10
4.52E-06
9.10E-11
8.08E-11
1.26E-14
9.02E-11
1.34E-08
1.30E-06
1.21E-09
4.88E-10
3.39E-10
6.05E-08
1.04E-10
5.24E-13
5.30E-09
2.61E-11
1.03E-06
2.43E-08
5.39E-10
1.73E-06
3.98E-11
1.22E-05
3.28E-11
2.64E-07
4.27E-09
1.61E-12
4.12E-07
4.40E-12
6.63E-07
2.27E-11
1.41E-11
4.18E-07
1.58E-14
2.40E-07
4.73E-10
7.17E-07
7.84E-15
1.88E-08
8.56E-08
2.08E-11
1.12E-15
9.28E-08
6.63E-10
1.49E-10
1.07E-05
4.01E-10
6.23E-07
1.42E-09
1.31E-11
1.45E-09
8.20E-12
1.88E-11
3.18E-12
1.21E-07
1.38E-09
2.10E-12
5.80E-08
1.75E-08
1.06E-12
1.69E-05
5.79E-07
2.82E-10
3.98E-14
9.29E-13
3.25E-08
4.58E-13
7.63E-09
1.12E-08
1.09E-12
1.94E-05
9.21E-12
6.70E-13
2.84E-09
4.37E-10
1.09E-05
1.94E-06
1.31E-08
2.19E-09
9.41E-09
3.76E-14
1.17E-11
5.24E-12
3.33E-10
7.04E-07
1.89E-06
3.40E-07
9.00E-08
8.16E-10
1.01E-10
4.63E-07
8.58E-11
8.33E-09
1.09E-09
2.45E-08
2.43E-13
1.05E-10
9.92E-09
1.33E-09
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15039
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12342
15266
15266
15266
15266
15266
15266
15145
15266
15266
15266
15266
14385
15266
15266
15039
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12140
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
11618
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12086
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
-9.556
9.543
9.539
9.538
9.538
-9.538
-9.536
-9.535
-9.535
9.532
-9.531
-9.529
-9.523
9.52
-9.516
-9.515
9.507
9.5
-9.496
9.492
-9.487
9.484
-9.483
-9.481
9.471
9.47
-9.462
-9.461
9.46
9.456
-9.454
9.452
-9.447
9.447
9.445
9.435
9.434
-9.416
-9.413
9.409
9.402
9.398
9.396
-9.392
9.383
9.383
-9.38
9.379
9.37
-9.363
-9.361
-9.36
-9.35
9.344
-9.339
-9.337
9.337
9.33
-9.324
-9.321
-9.321
-9.314
-9.313
-9.312
-9.308
-9.306
9.303
-9.3
9.298
9.297
9.296
9.289
-9.285
9.281
-9.281
9.28
-9.275
9.272
9.271
-9.271
-9.263
9.251
9.251
9.235
-9.234
9.231
9.228
9.222
-9.221
9.22
9.207
-9.201
-9.196
-9.195
9.195
-9.192
-9.183
-9.181
-9.18
-9.174
-9.162
9.161
-9.149
9.148
9.139
9.12
-9.11
-9.109
-9.104
9.097
-9.093
-9.087
-9.073
-9.068
-9.065
9.062
9.061
-9.058
-9.057
-9.055
9.053
9.052
-9.052
9.05
9.049
-9.046
9.046
9.046
9.044
-9.044
-9.042
9.035
-9.03
-9.03
-9.029
9.026
9.023
-9.021
9.017
-9.014
-9.012
-9.005
9.004
8.997
-8.992
-8.989
-8.984
-8.981
-8.979
-8.972
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.22E-21
1.38E-21
1.44E-21
1.45E-21
1.45E-21
1.46E-21
1.48E-21
1.50E-21
1.51E-21
1.55E-21
1.56E-21
1.59E-21
1.68E-21
1.72E-21
1.80E-21
1.82E-21
1.97E-21
2.10E-21
2.17E-21
2.26E-21
2.38E-21
2.44E-21
2.47E-21
2.53E-21
2.78E-21
2.80E-21
3.01E-21
3.04E-21
3.07E-21
3.21E-21
3.26E-21
3.31E-21
3.47E-21
3.49E-21
3.54E-21
3.90E-21
3.96E-21
4.68E-21
4.84E-21
5.01E-21
5.34E-21
5.58E-21
5.67E-21
5.87E-21
6.39E-21
6.42E-21
6.61E-21
6.67E-21
7.29E-21
7.77E-21
7.92E-21
7.95E-21
8.78E-21
9.30E-21
9.76E-21
9.94E-21
9.95E-21
1.06E-20
1.12E-20
1.15E-20
1.15E-20
1.23E-20
1.24E-20
1.26E-20
1.31E-20
1.32E-20
1.36E-20
1.40E-20
1.44E-20
1.45E-20
1.46E-20
1.56E-20
1.62E-20
1.68E-20
1.68E-20
1.69E-20
1.77E-20
1.83E-20
1.84E-20
1.85E-20
1.98E-20
2.22E-20
2.23E-20
2.59E-20
2.62E-20
2.69E-20
2.76E-20
2.90E-20
2.93E-20
2.96E-20
3.35E-20
3.53E-20
3.71E-20
3.75E-20
3.77E-20
3.86E-20
4.20E-20
4.28E-20
4.30E-20
4.57E-20
5.09E-20
5.16E-20
5.72E-20
5.78E-20
6.33E-20
7.49E-20
8.24E-20
8.29E-20
8.72E-20
9.28E-20
9.66E-20
1.02E-19
1.16E-19
1.22E-19
1.25E-19
1.28E-19
1.29E-19
1.33E-19
1.34E-19
1.37E-19
1.40E-19
1.40E-19
1.40E-19
1.43E-19
1.44E-19
1.48E-19
1.48E-19
1.49E-19
1.51E-19
1.51E-19
1.54E-19
1.63E-19
1.71E-19
1.72E-19
1.73E-19
1.77E-19
1.83E-19
1.87E-19
1.94E-19
1.99E-19
2.03E-19
2.16E-19
2.18E-19
2.31E-19
2.42E-19
2.50E-19
2.61E-19
2.68E-19
2.73E-19
2.92E-19
?
?
?
+
+
+
?
?
+
?
?
?
?
?
?
+
?
?
?
?
?
?
+
+
?
+
?
?
+
?
?
?
?
?
?
+
+
+
?
?
+
?
?
?
?
?
+
?
?
?
?
?
?
+
+
?
?
+
?
?
?
?
+
+
?
?
?
?
+
+
?
+
+
+
+
?
+
+
+
+
?
+
?
?
?
?
?
?
?
?
+
?
?
?
?
?
?
?
+
?
+
394
394
0
394
0
0
394
394
394
0
0
394
0
0
0
0
0
394
394
0
394
394
394
0
0
0
394
0
0
394
394
394
394
394
0
394
394
394
0
394
394
0
0
394
394
0
394
0
0
0
0
394
0
394
394
394
0
394
0
394
394
394
0
0
0
0
0
394
0
0
0
394
394
394
0
394
0
394
0
394
394
0
0
394
394
0
0
0
394
394
0
394
394
394
394
0
0
394
0
394
394
0
394
394
394
0
394
394
394
394
0
394
394
394
394
394
0
394
394
0
0
0
394
0
0
0
394
394
0
0
394
0
394
394
0
0
394
0
394
394
394
0
0
0
394
394
394
394
0
394
-0.011
-0.010
ns
-0.001
ns
ns
0.009
0.014
0.007
ns
ns
0.014
ns
ns
ns
ns
ns
-0.006
-0.007
ns
-0.007
-0.012
0.008
ns
ns
ns
-0.005
ns
ns
-0.008
0.000
-0.001
0.000
-0.001
ns
0.005
0.004
-0.005
ns
0.010
-0.006
ns
ns
0.002
-0.001
ns
-0.010
ns
ns
ns
ns
-0.004
ns
0.005
0.002
0.011
ns
0.000
ns
-0.006
0.011
-0.006
ns
ns
ns
ns
ns
0.002
ns
ns
ns
-0.004
-0.008
-0.014
ns
-0.004
ns
-0.011
ns
0.002
0.001
ns
ns
-0.012
0.008
ns
ns
ns
-0.002
-0.017
ns
0.000
0.002
-0.006
-0.009
ns
ns
-0.006
ns
-0.001
-0.006
ns
0.009
-0.005
0.015
ns
0.010
0.009
0.012
0.005
ns
0.009
0.011
0.001
0.008
-0.004
ns
-0.018
0.003
ns
ns
ns
-0.001
ns
ns
ns
-0.016
-0.021
ns
ns
0.001
ns
-0.005
-0.003
ns
ns
-0.014
ns
-0.009
-0.005
-0.003
ns
ns
ns
-0.008
0.006
-0.008
-0.010
ns
0.001
0.003
0.003
ns
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
ns
ns
ns
ns
ns
0.004
0.003
ns
0.003
0.003
0.003
ns
ns
ns
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
0.003
ns
0.003
ns
ns
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
ns
ns
ns
0.003
ns
ns
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
ns
ns
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
ns
0.003
ns
0.004
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.004
0.003
0.004
ns
0.003
0.003
ns
ns
ns
0.004
ns
ns
ns
0.003
0.003
ns
ns
0.003
ns
0.004
0.003
ns
ns
0.004
ns
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
3.22E-04
1.03E-03
ns
8.58E-01
ns
ns
3.22E-03
9.35E-06
3.90E-02
ns
ns
5.38E-07
ns
ns
ns
ns
ns
8.85E-02
4.08E-02
ns
3.88E-02
8.00E-04
2.40E-03
ns
ns
ns
1.23E-01
ns
ns
9.83E-03
9.69E-01
8.77E-01
9.98E-01
6.68E-01
ns
1.12E-01
1.64E-01
1.91E-01
ns
1.21E-03
5.46E-02
ns
ns
5.36E-01
6.96E-01
ns
1.38E-03
ns
ns
ns
ns
2.21E-01
ns
1.27E-01
5.28E-01
2.09E-04
ns
9.03E-01
ns
5.75E-02
1.46E-04
8.10E-02
ns
ns
ns
ns
ns
5.65E-01
ns
ns
ns
2.21E-01
2.07E-02
2.59E-05
ns
2.35E-01
ns
4.41E-04
ns
5.76E-01
7.54E-01
ns
ns
7.48E-05
1.66E-02
ns
ns
ns
6.46E-01
4.81E-07
ns
9.04E-01
4.86E-01
4.82E-02
8.57E-03
ns
ns
5.16E-02
ns
8.45E-01
6.49E-02
ns
7.62E-03
9.83E-02
1.25E-07
ns
1.06E-03
5.00E-03
1.51E-04
1.01E-01
ns
4.50E-03
6.08E-04
7.06E-01
2.64E-03
2.46E-01
ns
4.75E-08
4.00E-01
ns
ns
ns
6.96E-01
ns
ns
ns
6.14E-07
1.93E-09
ns
ns
7.68E-01
ns
1.70E-01
3.38E-01
ns
ns
1.12E-04
ns
1.02E-02
1.66E-01
4.01E-01
ns
ns
ns
2.07E-02
4.20E-02
9.90E-03
1.16E-03
ns
7.85E-01
?
?
?
+
+
+
?
+
?
?
?
?
?
+
+
?
?
?
?
?
+
+
?
+
?
?
?
+
?
?
?
+
?
?
+
?
+
+
?
+
?
+
?
?
?
?
?
?
?
?
?
+
?
?
?
+
?
+
+
?
?
+
+
?
?
?
+
?
+
+
+
+
?
+
?
?
?
+
+
?
+
+
+
+
?
+
+
+
+
?
+
+
?
?
?
+
?
?
?
?
?
+
?
+
?
?
+
?
+
+
?
?
?
+
?
+
394
394
0
394
0
0
394
394
394
394
0
394
0
0
0
0
0
394
394
0
394
394
394
0
0
394
394
0
0
394
394
394
394
394
0
394
394
394
0
394
394
0
0
394
0
0
394
0
394
0
0
394
0
394
394
394
0
394
0
394
394
394
0
0
0
0
0
394
0
0
0
0
394
394
0
0
0
394
0
394
394
0
0
394
394
0
0
0
394
394
0
394
394
394
394
394
0
394
0
0
394
0
394
394
394
0
394
394
394
394
0
394
394
394
394
394
0
394
394
0
0
0
394
0
0
0
394
394
0
0
394
0
394
394
0
0
394
0
394
394
394
0
0
0
394
394
394
394
0
394
-0.006
0.000
ns
-0.001
ns
ns
0.002
0.012
0.011
-0.017
ns
0.008
ns
ns
ns
ns
ns
0.003
0.001
ns
-0.002
-0.005
-0.001
ns
ns
-0.011
-0.010
ns
ns
0.000
-0.013
-0.016
-0.015
0.014
ns
0.012
-0.005
0.000
ns
-0.001
-0.007
ns
ns
0.014
ns
ns
-0.013
ns
0.006
ns
ns
0.000
ns
-0.010
0.010
0.013
ns
0.006
ns
-0.008
0.010
-0.009
ns
ns
ns
ns
ns
-0.002
ns
ns
ns
ns
0.004
-0.009
ns
ns
ns
0.002
ns
0.005
0.007
ns
ns
0.001
0.008
ns
ns
ns
-0.005
0.004
ns
0.013
0.012
-0.007
0.004
0.003
ns
0.007
ns
ns
-0.013
ns
0.012
0.000
0.015
ns
0.013
0.010
0.004
0.001
ns
0.001
0.010
-0.003
0.003
0.009
ns
0.004
0.012
ns
ns
ns
0.010
ns
ns
ns
-0.015
-0.008
ns
ns
0.010
ns
0.002
-0.005
ns
ns
0.007
ns
0.003
-0.001
0.007
ns
ns
ns
-0.016
0.007
-0.005
-0.003
ns
0.007
0.003
0.003
ns
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
ns
ns
ns
0.003
0.003
ns
0.004
0.004
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.004
ns
ns
0.003
ns
ns
0.003
ns
0.003
ns
ns
0.003
ns
0.004
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
ns
ns
ns
0.003
ns
ns
ns
ns
0.003
0.003
ns
ns
ns
0.003
ns
0.003
0.003
ns
ns
0.004
0.003
ns
ns
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
0.004
0.003
ns
ns
ns
0.003
ns
ns
ns
0.003
0.004
ns
ns
0.003
ns
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
3.38E-02
9.38E-01
ns
8.10E-01
ns
ns
5.72E-01
1.35E-04
2.54E-04
1.21E-06
ns
4.16E-03
ns
ns
ns
ns
ns
3.46E-01
8.43E-01
ns
5.60E-01
1.50E-01
6.74E-01
ns
ns
2.55E-04
2.34E-03
ns
ns
9.84E-01
8.06E-06
1.27E-06
5.69E-06
7.21E-06
ns
1.58E-04
1.08E-01
9.65E-01
ns
6.01E-01
5.22E-02
ns
ns
4.88E-06
ns
ns
5.73E-05
ns
9.70E-02
ns
ns
9.89E-01
ns
3.87E-03
2.18E-03
6.74E-06
ns
7.06E-02
ns
1.07E-02
3.24E-04
7.77E-03
ns
ns
ns
ns
ns
5.47E-01
ns
ns
ns
ns
1.94E-01
8.42E-03
ns
ns
ns
4.48E-01
ns
1.24E-01
3.91E-02
ns
ns
7.08E-01
6.84E-03
ns
ns
ns
1.07E-01
2.72E-01
ns
9.95E-05
1.02E-04
2.99E-02
1.88E-01
3.36E-01
ns
1.32E-02
ns
ns
1.12E-04
ns
1.05E-04
9.60E-01
1.18E-06
ns
1.45E-05
4.08E-04
1.80E-01
8.16E-01
ns
7.29E-01
2.13E-04
3.44E-01
2.20E-01
1.11E-02
ns
2.96E-01
2.23E-04
ns
ns
ns
3.16E-03
ns
ns
ns
2.25E-06
2.91E-02
ns
ns
1.30E-03
ns
4.78E-01
1.12E-01
ns
ns
5.35E-02
ns
3.33E-01
8.46E-01
2.59E-02
ns
ns
ns
4.44E-07
4.53E-02
1.12E-01
3.06E-01
ns
3.82E-02
+?+
?+++
--+-+?
+?
+-++
+-?
++
++
-?
-++
+?+
++
+-+++
-+
-++
-?+
++
++
++
--++
--++
++
?+
?+
??+?+
+-?-+
+?
?-?
-+?+++-+-++
-++
++
+++
++?++
++
++
-++
-+?
-++
+++
++
++
-++
++
++
--+
+-?-+-??-+++
++
-+-++
-+
+-?-++
-+
?+
++?+
-+
+?+
+-++
-+?
+++
-+
-+++
++
-?
++-?++
-++?
++?--
515
213
213
515
515
515
515
515
515
302
302
515
515
515
515
302
515
515
515
0
515
515
515
213
515
515
515
515
515
515
515
515
515
213
515
515
515
515
515
515
515
515
515
515
213
213
213
213
515
213
515
515
213
515
302
213
302
515
515
213
515
515
515
515
515
515
515
515
515
515
515
515
515
515
213
515
515
515
515
515
515
302
515
515
515
515
515
515
515
515
515
515
515
515
515
515
213
515
515
515
213
213
515
515
515
515
515
515
515
515
515
515
515
213
515
515
515
213
515
515
213
515
515
213
515
515
515
515
515
0
515
515
515
515
515
515
515
302
515
515
515
213
515
515
515
302
515
515
213
515
0.612
1.598
-1.450
0.661
2.739
-1.254
-4.866
-0.771
-1.129
5.785
0.240
-0.456
-0.664
2.117
-0.410
-0.543
2.824
3.140
-1.016
ns
-4.077
2.609
0.076
0.054
0.921
1.751
-1.013
-0.628
1.038
1.684
-0.950
1.560
-1.405
0.908
4.007
2.349
1.280
-1.512
-2.323
3.111
-0.440
-2.191
2.684
1.838
3.041
4.509
-0.397
-1.363
1.625
0.063
1.622
-2.334
-1.472
-0.333
0.964
-1.889
-1.563
-1.022
0.647
-0.273
0.028
0.284
-1.695
-1.465
0.671
-2.125
1.386
-2.426
2.630
1.542
1.195
1.948
0.226
-1.682
-1.039
2.820
1.393
0.809
-1.063
1.206
-1.776
2.014
-1.162
1.781
-0.034
3.865
2.421
0.233
-1.206
2.018
3.509
1.693
-2.167
0.232
-0.299
-0.469
-1.844
-2.819
-0.650
-1.438
-0.876
-1.538
-1.237
-0.401
2.990
0.739
-2.605
0.527
-2.058
3.022
-0.588
0.078
-1.943
-0.937
-2.393
3.831
1.661
0.256
0.349
-0.224
1.117
0.507
-0.428
2.248
1.281
-2.449
3.166
-2.743
0.152
ns
0.760
3.781
-2.978
-1.473
-1.749
2.758
2.024
-0.584
-0.353
1.092
-1.580
-0.345
4.065
-1.594
-0.303
0.847
1.127
-0.052
-0.782
-2.084
5.40E-01
1.10E-01
1.47E-01
5.09E-01
6.16E-03
2.10E-01
1.14E-06
4.41E-01
2.59E-01
7.23E-09
8.10E-01
6.49E-01
5.07E-01
3.43E-02
6.82E-01
5.87E-01
4.75E-03
1.69E-03
3.10E-01
ns
4.56E-05
9.07E-03
9.40E-01
9.57E-01
3.57E-01
7.99E-02
3.11E-01
5.30E-01
3.00E-01
9.21E-02
3.42E-01
1.19E-01
1.60E-01
3.64E-01
6.15E-05
1.88E-02
2.01E-01
1.30E-01
2.02E-02
1.87E-03
6.60E-01
2.85E-02
7.28E-03
6.61E-02
2.36E-03
6.52E-06
6.91E-01
1.73E-01
1.04E-01
9.50E-01
1.05E-01
1.96E-02
1.41E-01
7.39E-01
3.35E-01
5.89E-02
1.18E-01
3.07E-01
5.18E-01
7.85E-01
9.78E-01
7.77E-01
9.02E-02
1.43E-01
5.02E-01
3.36E-02
1.66E-01
1.53E-02
8.54E-03
1.23E-01
2.32E-01
5.14E-02
8.21E-01
9.25E-02
2.99E-01
4.81E-03
1.64E-01
4.18E-01
2.88E-01
2.28E-01
7.57E-02
4.40E-02
2.45E-01
7.50E-02
9.73E-01
1.11E-04
1.55E-02
8.16E-01
2.28E-01
4.36E-02
4.50E-04
9.05E-02
3.02E-02
8.16E-01
7.65E-01
6.39E-01
6.52E-02
4.82E-03
5.16E-01
1.51E-01
3.81E-01
1.24E-01
2.16E-01
6.89E-01
2.79E-03
4.60E-01
9.20E-03
5.98E-01
3.96E-02
2.51E-03
5.56E-01
9.38E-01
5.20E-02
3.49E-01
1.67E-02
1.27E-04
9.67E-02
7.98E-01
7.27E-01
8.23E-01
2.64E-01
6.12E-01
6.69E-01
2.46E-02
2.00E-01
1.43E-02
1.54E-03
6.10E-03
8.80E-01
ns
4.48E-01
1.56E-04
2.91E-03
1.41E-01
8.03E-02
5.82E-03
4.29E-02
5.59E-01
7.24E-01
2.75E-01
1.14E-01
7.30E-01
4.80E-05
1.11E-01
7.62E-01
3.97E-01
2.60E-01
9.58E-01
4.34E-01
3.72E-02
?
?
+
+
+
+
+
?
+
?
+
+
+
+
?
+
+
+
+
+
+
?
?
?
?
+
?
+
?
+
?
+
+
+
?
+
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
?
?
?
+
+
+
+
+
?
+
+
?
?
+
?
+
+
+
+
?
+
+
+
+
+
?
+
+
?
-
299
0
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
0
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
0
0
0
0
299
0
299
299
0
299
299
0
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
0
0
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
0
299
299
0
299
299
0
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
0
299
-0.008
ns
ns
0.002
0.056
-0.019
-0.003
-0.009
-0.013
0.024
-0.011
-0.020
-0.001
0.006
-0.001
-0.010
0.018
-0.002
-0.011
ns
-0.032
0.009
-0.005
ns
0.006
0.023
-0.004
-0.015
0.004
0.000
-0.006
0.015
-0.008
ns
0.008
0.004
0.016
-0.001
-0.009
0.024
0.004
-0.001
0.034
-0.018
ns
ns
ns
ns
0.008
ns
0.002
-0.008
ns
0.007
0.000
ns
0.002
0.014
0.016
ns
-0.004
0.003
-0.009
-0.018
0.003
-0.019
0.015
-0.021
0.023
0.013
0.003
0.001
-0.008
0.007
ns
0.025
-0.002
0.009
0.004
-0.007
-0.023
0.007
0.016
0.009
-0.009
0.018
0.017
0.007
-0.002
0.005
0.015
-0.014
-0.012
-0.026
-0.003
-0.001
ns
-0.015
-0.011
-0.010
ns
ns
-0.017
0.006
0.014
0.009
-0.004
-0.007
-0.007
0.012
-0.015
0.002
-0.016
ns
-0.011
0.014
0.009
ns
-0.012
-0.005
ns
0.008
-0.002
ns
0.004
-0.019
0.003
0.003
0.009
ns
-0.001
0.015
0.012
-0.016
-0.016
0.038
0.014
-0.007
0.018
-0.013
-0.004
ns
0.030
0.010
-0.002
-0.010
-0.002
-0.007
ns
-0.019
0.005
ns
ns
0.004
0.011
0.004
0.002
0.006
0.006
0.005
0.006
0.005
0.007
0.002
0.004
0.006
0.006
0.005
0.005
ns
0.009
0.003
0.004
ns
0.002
0.006
0.004
0.005
0.004
0.007
0.003
0.008
0.003
ns
0.004
0.006
0.004
0.002
0.003
0.005
0.005
0.003
0.007
0.005
ns
ns
ns
ns
0.005
ns
0.002
0.005
ns
0.009
0.004
ns
0.002
0.008
0.007
ns
0.006
0.010
0.003
0.005
0.009
0.008
0.005
0.007
0.006
0.006
0.002
0.003
0.004
0.007
ns
0.008
0.006
0.003
0.012
0.006
0.006
0.002
0.010
0.007
0.005
0.012
0.008
0.004
0.003
0.002
0.004
0.004
0.004
0.008
0.006
0.002
ns
0.005
0.006
0.007
ns
ns
0.004
0.003
0.005
0.004
0.003
0.007
0.003
0.004
0.005
0.007
0.004
ns
0.007
0.005
0.004
ns
0.006
0.006
ns
0.004
0.003
ns
0.004
0.004
0.002
0.003
0.004
ns
0.005
0.004
0.007
0.004
0.006
0.011
0.008
0.005
0.010
0.004
0.003
ns
0.006
0.011
0.002
0.005
0.004
0.005
ns
0.004
9.47E-02
ns
ns
6.76E-01
1.52E-06
8.75E-06
1.37E-01
9.50E-02
2.16E-02
2.37E-06
5.63E-02
1.52E-04
8.69E-01
6.29E-03
8.31E-01
9.16E-02
4.70E-03
6.23E-01
4.38E-02
ns
2.28E-04
8.01E-04
2.11E-01
ns
1.11E-02
1.19E-04
2.66E-01
4.03E-03
3.39E-01
9.78E-01
3.53E-02
6.87E-02
8.52E-03
ns
4.90E-02
5.14E-01
9.81E-05
5.77E-01
2.58E-04
1.10E-05
3.96E-01
6.26E-01
4.41E-06
5.42E-04
ns
ns
ns
ns
9.80E-02
ns
3.35E-01
1.07E-01
ns
4.07E-01
9.53E-01
ns
3.32E-01
7.40E-02
2.06E-02
ns
5.13E-01
7.91E-01
2.27E-03
7.40E-04
7.21E-01
2.25E-02
5.23E-03
2.74E-03
2.37E-04
3.15E-02
1.95E-01
7.84E-01
8.22E-02
3.33E-01
ns
2.19E-03
7.99E-01
4.86E-04
7.71E-01
2.22E-01
3.65E-04
6.43E-03
1.04E-01
2.07E-01
6.33E-02
1.15E-01
2.47E-02
8.35E-02
4.38E-01
3.96E-02
2.54E-04
8.67E-04
3.83E-03
1.08E-03
5.69E-01
6.94E-01
ns
5.36E-03
5.96E-02
1.40E-01
ns
ns
1.24E-05
9.62E-02
2.92E-03
1.87E-02
1.50E-01
2.79E-01
2.34E-02
1.53E-03
3.02E-03
7.72E-01
4.81E-04
ns
1.09E-01
1.80E-03
4.71E-02
ns
4.15E-02
3.56E-01
ns
4.19E-02
5.45E-01
ns
3.65E-01
2.23E-06
1.61E-01
3.93E-01
2.21E-02
ns
9.03E-01
3.27E-04
8.68E-02
2.44E-04
4.28E-03
6.22E-04
8.84E-02
1.39E-01
6.35E-02
3.25E-03
2.34E-01
ns
5.44E-07
3.61E-01
3.16E-01
2.52E-02
5.86E-01
1.24E-01
ns
1.31E-05
--+
-+
-++
--+
-+??+
-+
+++
-?+
+?
-+
-?+
--?
-+----+
++
++
-+
++
-+
+-++
+-++
++
++
-?
-+
++?
++
-+?
-+
+++
-++
++
?+
-?+
-+
--?
-+
-+
++
---+
-+?
+?
-+
-+--+
-?
-+
++?
-+
+-?
?+
-+
++
+?
++
++
+-?
++
++
++
++-+
++
+?
+--+
---+
-+
-+
-+
-+
-+
-++-+
-+
-+
+?
++
+-?
---+
++
-+
++
-+
--+
++
-+
?+++
++
---+
-+
?
-+
++++-+
+?-+
--?
-+
567
567
567
567
567
567
567
567
567
354
354
567
567
567
567
354
213
567
567
354
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
213
567
567
213
567
567
567
567
567
567
354
567
354
567
567
213
567
567
567
567
567
567
567
213
213
567
567
567
567
567
213
567
567
213
567
567
213
354
567
567
213
567
567
567
213
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
213
567
567
567
567
567
567
567
567
567
567
567
354
567
567
567
567
567
567
567
0
567
567
567
567
567
567
567
354
567
567
213
567
-2.871
1.528
0.681
-3.652
2.478
-2.583
-1.960
-4.342
-0.744
-0.473
0.966
1.326
0.610
4.007
-2.990
2.402
1.694
2.087
-1.750
0.187
-3.032
-0.745
-3.714
0.023
-1.439
-1.451
-3.217
1.108
2.178
0.982
0.295
3.370
0.383
-1.213
-4.090
3.330
-1.915
-2.091
1.616
4.373
3.866
-1.826
-0.493
1.306
1.956
0.198
-3.919
1.119
-0.197
-0.955
0.392
-2.303
0.681
1.107
2.067
-2.068
0.871
2.181
-2.336
-1.112
0.358
-1.206
1.858
-3.721
-0.364
0.270
-1.156
2.265
1.890
-0.041
-1.837
0.951
-3.051
-0.343
-0.399
0.323
-0.484
1.706
0.230
-2.985
-1.405
1.928
1.337
2.768
0.925
1.942
3.741
0.414
-2.075
3.320
3.124
1.180
-1.074
-2.957
1.748
0.657
0.277
-0.232
-2.671
0.230
-2.123
-2.138
0.938
0.775
0.796
2.284
0.193
-0.373
-2.703
-0.582
-2.247
1.011
0.361
-0.655
0.942
3.058
-0.649
-0.211
-1.657
-2.616
-1.568
2.483
0.344
0.945
-0.130
-2.455
-0.461
2.422
1.723
-2.442
-0.875
0.316
1.212
-1.809
-2.304
1.929
-0.608
ns
-0.184
-2.484
-0.380
-0.256
0.874
0.824
1.177
-2.578
-0.271
-3.008
-0.982
-1.097
4.10E-03
1.27E-01
4.96E-01
2.61E-04
1.32E-02
9.79E-03
5.00E-02
1.41E-05
4.57E-01
6.36E-01
3.34E-01
1.85E-01
5.42E-01
6.15E-05
2.79E-03
1.63E-02
9.03E-02
3.69E-02
8.01E-02
8.52E-01
2.43E-03
4.56E-01
2.04E-04
9.82E-01
1.50E-01
1.47E-01
1.30E-03
2.68E-01
2.94E-02
3.26E-01
7.68E-01
7.52E-04
7.02E-01
2.25E-01
4.31E-05
8.67E-04
5.55E-02
3.65E-02
1.06E-01
1.22E-05
1.11E-04
6.78E-02
6.22E-01
1.92E-01
5.05E-02
8.43E-01
8.91E-05
2.63E-01
8.44E-01
3.40E-01
6.95E-01
2.13E-02
4.96E-01
2.68E-01
3.87E-02
3.86E-02
3.84E-01
2.92E-02
1.95E-02
2.66E-01
7.20E-01
2.28E-01
6.31E-02
1.99E-04
7.16E-01
7.87E-01
2.48E-01
2.35E-02
5.88E-02
9.68E-01
6.62E-02
3.42E-01
2.28E-03
7.31E-01
6.90E-01
7.47E-01
6.28E-01
8.81E-02
8.18E-01
2.83E-03
1.60E-01
5.38E-02
1.81E-01
5.64E-03
3.55E-01
5.21E-02
1.84E-04
6.79E-01
3.80E-02
9.02E-04
1.79E-03
2.38E-01
2.83E-01
3.11E-03
8.05E-02
5.11E-01
7.82E-01
8.16E-01
7.56E-03
8.18E-01
3.38E-02
3.25E-02
3.48E-01
4.38E-01
4.26E-01
2.24E-02
8.47E-01
7.09E-01
6.87E-03
5.61E-01
2.47E-02
3.12E-01
7.18E-01
5.12E-01
3.46E-01
2.23E-03
5.17E-01
8.33E-01
9.75E-02
8.90E-03
1.17E-01
1.30E-02
7.31E-01
3.45E-01
8.96E-01
1.41E-02
6.45E-01
1.55E-02
8.49E-02
1.46E-02
3.82E-01
7.52E-01
2.26E-01
7.04E-02
2.12E-02
5.37E-02
5.43E-01
ns
8.54E-01
1.30E-02
7.04E-01
7.98E-01
3.82E-01
4.10E-01
2.39E-01
9.94E-03
7.87E-01
2.63E-03
3.26E-01
2.73E-01
+
+
+
?
+
+
+
?
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
+
?
?
+
+
+
+
+
+
?
+
+
?
+
+
+
?
+
+
+
?
+
?
?
?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
?
?
+
+
+
869
869
869
869
869
869
869
869
869
0
869
869
869
0
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
0
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
0
869
869
869
0
869
869
869
869
869
869
0
869
0
0
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
0
869
869
0
869
869
869
869
869
-0.004
0.000
0.000
0.000
-0.004
0.007
-0.001
-0.002
0.002
ns
0.001
0.000
0.001
ns
-0.001
0.000
0.006
-0.003
-0.003
ns
0.002
0.003
-0.002
0.004
0.005
-0.002
0.001
-0.002
0.005
0.000
0.000
0.002
0.004
0.009
0.000
-0.002
0.000
0.004
0.001
-0.002
0.001
-0.003
-0.002
-0.002
0.003
-0.005
0.002
ns
0.005
-0.005
0.000
0.003
0.002
-0.004
ns
-0.002
ns
-0.002
0.008
0.001
0.000
0.001
-0.003
-0.001
0.003
-0.001
-0.003
-0.001
0.000
-0.002
0.004
-0.001
0.001
-0.003
ns
0.003
0.006
ns
0.001
0.000
0.002
ns
-0.002
-0.002
0.000
0.000
0.001
0.000
ns
0.005
ns
ns
-0.001
ns
0.003
-0.010
-0.001
0.004
-0.003
0.001
-0.002
-0.001
0.000
-0.002
0.005
-0.002
-0.001
0.002
0.000
-0.001
-0.005
0.002
-0.001
-0.001
0.000
0.004
0.000
-0.001
0.002
0.000
0.006
0.000
0.002
0.003
0.004
0.001
-0.003
0.001
0.000
-0.003
0.000
0.005
-0.002
0.002
0.005
-0.002
0.004
ns
0.003
0.001
-0.001
ns
0.000
0.000
ns
0.003
0.000
0.001
-0.001
0.002
0.001
0.000
0.001
0.001
0.002
0.001
0.002
0.001
0.001
ns
0.001
0.001
0.001
ns
0.001
0.001
0.002
0.001
0.002
ns
0.001
0.002
0.002
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.003
0.001
0.001
0.001
0.001
ns
0.001
ns
0.003
0.003
0.001
0.001
0.001
0.001
0.001
0.002
0.002
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.002
ns
0.002
0.002
ns
0.001
0.001
0.001
ns
0.001
0.002
0.001
0.001
0.001
0.004
ns
0.001
ns
ns
0.001
ns
0.001
0.003
0.002
0.001
0.003
0.001
0.001
0.003
0.001
0.002
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.002
0.005
0.001
0.001
0.002
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.002
0.002
0.001
0.002
0.001
ns
0.002
0.001
0.001
ns
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
1.48E-03
9.59E-01
7.22E-01
7.79E-01
9.96E-02
1.97E-06
5.35E-01
1.50E-01
1.60E-02
ns
1.34E-01
5.38E-01
9.79E-02
ns
3.06E-01
6.04E-01
9.08E-04
6.13E-03
8.33E-02
ns
9.23E-02
1.16E-01
1.50E-01
2.09E-06
5.23E-03
8.98E-03
4.92E-01
4.04E-03
6.99E-10
8.14E-01
8.81E-01
1.10E-03
2.32E-04
5.02E-13
8.78E-01
3.56E-02
8.43E-01
1.71E-04
2.03E-01
3.11E-02
2.63E-01
6.04E-03
1.64E-02
7.16E-02
1.17E-05
5.11E-04
1.25E-01
ns
5.52E-05
7.59E-02
7.31E-01
4.70E-03
1.62E-01
5.01E-03
ns
1.53E-02
ns
5.82E-01
1.91E-02
3.60E-01
7.40E-01
3.73E-01
2.32E-05
4.54E-01
1.29E-01
6.66E-01
5.64E-02
2.95E-01
9.41E-01
5.05E-02
3.95E-05
3.44E-01
5.87E-01
7.97E-02
ns
1.40E-01
5.67E-03
ns
2.88E-01
5.60E-01
4.98E-02
ns
5.95E-02
1.67E-01
6.51E-01
8.08E-01
2.04E-01
9.56E-01
ns
9.20E-08
ns
ns
3.03E-01
ns
1.26E-02
1.41E-03
3.65E-01
1.95E-03
2.29E-01
1.39E-01
2.33E-02
7.29E-01
9.86E-01
1.77E-01
1.52E-07
1.78E-01
4.90E-01
1.81E-01
7.20E-01
1.40E-01
1.32E-05
2.92E-01
3.59E-01
6.13E-01
6.66E-01
1.14E-02
9.10E-01
8.33E-01
7.31E-02
9.98E-01
7.23E-03
9.26E-01
1.12E-01
1.09E-01
1.70E-03
2.88E-01
6.11E-03
4.80E-01
4.97E-01
2.08E-01
9.86E-01
1.33E-06
4.09E-01
1.72E-01
7.63E-04
4.13E-01
2.07E-03
ns
1.43E-01
1.01E-01
3.07E-02
ns
9.46E-01
7.26E-01
ns
1.44E-02
7.52E-01
2.81E-01
3.96E-01
1.42E-01
?
?
+
?
?
?
?
?
?
?
?
?
?
?
+
?
+
?
?
?
+
+
?
?
?
+
+
+
+
?
?
?
?
?
?
+
?
?
+
?
?
?
?
+
?
?
?
+
?
?
?
+
?
?
+
?
+
?
?
+
+
?
?
+
+
+
?
?
?
?
?
+
+
?
?
?
?
?
?
?
+
?
?
?
+
?
?
?
?
?
?
?
?
+
?
+
?
?
+
+
?
+
+
?
?
+
?
?
?
?
?
?
?
?
?
?
-
1244
0
0
1244
0
0
0
1244
1244
0
0
0
0
0
0
0
0
1244
0
1244
0
0
1244
1244
0
1244
1244
1244
1244
0
0
0
1244
1244
1244
1244
1244
1244
0
0
0
0
0
1244
0
1244
0
0
1244
0
0
0
0
1244
0
0
0
1244
0
1244
0
0
1244
1244
1244
1244
0
0
1244
0
1244
0
0
1244
1244
1244
0
0
1244
1244
1244
1244
1244
0
0
0
0
0
1244
1244
1244
1244
1244
0
1244
0
0
0
0
0
0
1244
0
0
0
1244
0
0
1244
0
1244
1244
1244
0
0
0
0
1244
1244
0
1244
0
1244
1244
0
1244
0
1244
1244
1244
0
1244
1244
0
1244
0
1244
0
0
0
0
1244
0
0
0
1244
0
0
0
1244
0.000
ns
ns
0.001
ns
ns
ns
-0.001
-0.001
ns
ns
ns
ns
ns
ns
ns
ns
0.001
ns
0.002
ns
ns
-0.002
-0.001
ns
0.002
0.000
-0.001
0.001
ns
ns
ns
-0.001
0.001
0.002
0.003
0.002
-0.001
ns
ns
ns
ns
ns
-0.002
ns
0.004
ns
ns
0.002
ns
ns
ns
ns
0.000
ns
ns
ns
0.001
ns
-0.001
ns
ns
0.000
-0.002
0.000
-0.003
ns
ns
0.004
ns
0.001
ns
ns
0.003
0.000
0.002
ns
ns
-0.003
0.001
-0.002
0.002
0.001
ns
ns
ns
ns
ns
-0.001
0.001
0.001
-0.001
0.000
ns
0.000
ns
ns
ns
ns
ns
ns
0.001
ns
ns
ns
0.002
ns
ns
-0.001
ns
-0.001
-0.001
-0.002
ns
ns
ns
ns
-0.003
-0.002
ns
0.004
ns
0.000
0.001
ns
-0.001
ns
0.001
0.003
-0.001
ns
0.002
0.000
ns
-0.001
ns
0.001
ns
ns
ns
ns
0.000
ns
ns
ns
-0.002
ns
ns
ns
-0.001
0.001
ns
ns
0.001
ns
ns
ns
0.000
0.000
ns
ns
ns
ns
ns
ns
ns
ns
0.000
ns
0.000
ns
ns
0.001
0.000
ns
0.000
0.000
0.000
0.000
ns
ns
ns
0.000
0.000
0.000
0.000
0.001
0.000
ns
ns
ns
ns
ns
0.001
ns
0.001
ns
ns
0.000
ns
ns
ns
ns
0.001
ns
ns
ns
0.001
ns
0.000
ns
ns
0.000
0.000
0.000
0.001
ns
ns
0.000
ns
0.000
ns
ns
0.001
0.000
0.001
ns
ns
0.001
0.000
0.000
0.001
0.000
ns
ns
ns
ns
ns
0.000
0.000
0.000
0.000
0.000
ns
0.000
ns
ns
ns
ns
ns
ns
0.001
ns
ns
ns
0.001
ns
ns
0.000
ns
0.000
0.001
0.000
ns
ns
ns
ns
0.000
0.000
ns
0.001
ns
0.000
0.001
ns
0.000
ns
0.000
0.001
0.000
ns
0.000
0.001
ns
0.000
ns
0.000
ns
ns
ns
ns
0.001
ns
ns
ns
0.000
ns
ns
ns
0.000
5.88E-01
ns
ns
7.12E-02
ns
ns
ns
2.28E-05
6.55E-02
ns
ns
ns
ns
ns
ns
ns
ns
9.49E-05
ns
9.77E-08
ns
ns
3.71E-05
1.43E-02
ns
8.75E-04
6.06E-01
1.78E-04
1.46E-10
ns
ns
ns
1.05E-05
1.88E-03
5.21E-06
3.13E-08
2.80E-05
6.45E-03
ns
ns
ns
ns
ns
1.29E-02
ns
2.50E-10
ns
ns
6.53E-10
ns
ns
ns
ns
5.80E-01
ns
ns
ns
2.73E-01
ns
1.61E-04
ns
ns
1.45E-02
4.74E-07
4.13E-01
4.64E-04
ns
ns
2.84E-33
ns
2.46E-07
ns
ns
9.78E-04
1.74E-01
2.29E-03
ns
ns
2.65E-06
2.17E-02
3.96E-06
4.19E-06
4.65E-03
ns
ns
ns
ns
ns
3.92E-03
1.53E-04
3.06E-03
6.95E-04
9.39E-01
ns
1.27E-01
ns
ns
ns
ns
ns
ns
1.63E-01
ns
ns
ns
4.30E-03
ns
ns
4.00E-04
ns
1.45E-02
1.07E-01
2.01E-06
ns
ns
ns
ns
2.82E-15
2.29E-05
ns
1.94E-12
ns
2.39E-01
8.48E-03
ns
1.26E-06
ns
6.48E-03
9.67E-07
3.80E-02
ns
4.38E-10
7.70E-01
ns
1.07E-07
ns
2.21E-03
ns
ns
ns
ns
9.93E-01
ns
ns
ns
1.90E-05
ns
ns
ns
4.04E-04
++
++
-++
+-+
---+
-?
---+
+?
-+
--?
++
-+
-?
--?
-?
++
++
++
--++
++
++-+
++
++
++-+
-?
++
++
-++
-+
+?
++
-+
+?
++
+--+
-+-?
-+
+?
+-+
-+
--+
--+
-+
+++
-+
+?
-+
++
++
-+
++
-?
+++
+?
+-+
-+
+?
++
++
-?
++
++
-+
-+
+++
-+
-+
-+
-+?
-----+
+-+++
+-+
--+
++
-+
--+
---+
++
-?
--+
++
++
+++
++
++
+++
++
+?
-+
++
++
-+
-+
+++
+?
+-+
-?
-+
+?
+-?
-+
++
++
-+
-+
362
362
362
362
362
362
362
362
362
134
362
362
362
134
362
362
134
362
362
134
362
134
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
134
362
362
362
362
362
362
134
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
134
362
362
362
134
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
134
362
362
134
362
134
362
134
362
362
362
362
362
1.589
0.573
-1.393
0.251
-0.466
1.165
-2.560
-2.579
0.215
-1.705
-1.519
-1.777
-0.569
0.001
1.050
-1.752
-0.921
1.291
-1.310
-0.858
-1.787
-1.730
-2.569
1.072
1.646
2.366
-1.788
-2.371
2.273
1.854
-0.346
-0.605
0.303
1.101
0.923
-0.334
-0.657
0.886
-0.882
0.618
0.144
-1.044
0.962
-1.194
0.421
0.788
-0.734
0.088
0.994
-1.961
-2.841
-0.263
-3.164
-0.696
-0.806
-0.060
0.526
-0.440
-1.158
0.124
-3.571
-0.659
-3.955
0.419
-0.131
-0.641
0.254
0.376
0.005
1.232
2.529
0.633
-0.169
1.766
-2.936
-0.464
0.530
0.056
-1.364
0.736
-0.771
0.157
1.538
0.562
-2.378
2.664
1.837
0.219
-0.344
-0.296
0.130
0.881
-0.809
-0.462
-1.055
0.360
-1.673
-2.152
-2.182
-3.946
0.071
-0.770
-2.020
-0.898
1.616
0.134
-0.771
-2.760
-1.146
1.533
0.302
-2.275
-1.573
-1.882
-2.513
0.619
0.421
-1.751
-2.912
-1.016
0.139
0.848
-1.251
0.560
0.849
2.165
-0.724
0.015
1.105
0.145
0.520
1.067
1.125
0.599
-0.425
-1.070
0.465
0.625
-0.476
0.871
-1.664
0.706
0.020
-0.017
-1.882
0.454
0.811
0.850
1.120
-0.541
1.12E-01
5.66E-01
1.64E-01
8.02E-01
6.42E-01
2.44E-01
1.05E-02
9.92E-03
8.30E-01
8.82E-02
1.29E-01
7.55E-02
5.69E-01
9.99E-01
2.94E-01
7.99E-02
3.57E-01
1.97E-01
1.90E-01
3.91E-01
7.40E-02
8.37E-02
1.02E-02
2.84E-01
9.97E-02
1.80E-02
7.37E-02
1.78E-02
2.30E-02
6.38E-02
7.29E-01
5.45E-01
7.62E-01
2.71E-01
3.56E-01
7.39E-01
5.11E-01
3.76E-01
3.78E-01
5.37E-01
8.86E-01
2.96E-01
3.36E-01
2.32E-01
6.74E-01
4.31E-01
4.63E-01
9.30E-01
3.20E-01
4.99E-02
4.50E-03
7.92E-01
1.56E-03
4.86E-01
4.20E-01
9.52E-01
5.99E-01
6.60E-01
2.47E-01
9.01E-01
3.55E-04
5.10E-01
7.66E-05
6.75E-01
8.96E-01
5.21E-01
8.00E-01
7.07E-01
9.96E-01
2.18E-01
1.15E-02
5.27E-01
8.66E-01
7.74E-02
3.32E-03
6.43E-01
5.96E-01
9.55E-01
1.73E-01
4.62E-01
4.41E-01
8.75E-01
1.24E-01
5.74E-01
1.74E-02
7.71E-03
6.63E-02
8.27E-01
7.31E-01
7.67E-01
8.97E-01
3.78E-01
4.18E-01
6.44E-01
2.91E-01
7.19E-01
9.42E-02
3.14E-02
2.91E-02
7.94E-05
9.43E-01
4.41E-01
4.34E-02
3.69E-01
1.06E-01
8.94E-01
4.40E-01
5.78E-03
2.52E-01
1.25E-01
7.63E-01
2.29E-02
1.16E-01
5.98E-02
1.20E-02
5.36E-01
6.74E-01
8.00E-02
3.59E-03
3.09E-01
8.90E-01
3.96E-01
2.11E-01
5.75E-01
3.96E-01
3.04E-02
4.69E-01
9.88E-01
2.69E-01
8.85E-01
6.03E-01
2.86E-01
2.61E-01
5.49E-01
6.71E-01
2.85E-01
6.42E-01
5.32E-01
6.34E-01
3.84E-01
9.61E-02
4.80E-01
9.84E-01
9.86E-01
5.99E-02
6.50E-01
4.17E-01
3.95E-01
2.63E-01
5.89E-01
14914
63497
37733
21330
3805
56251
11696
57596
9125
50399
49133
35366
66008
2006
26766
14172
25180
2308
62688
61042
68156
58584
437
18477
54341
14582
55243
44276
53256
64802
28861
64381
8192
61614
38489
33741
16957
15691
15385
48585
67434
68229
28586
49659
3466
13388
60365
40835
3975
39477
54292
60613
8977
61365
63491
59773
21469
44306
16624
25560
31859
16069
19709
17150
60519
59569
199
59738
331
55381
2177
31155
23768
9539
34879
52719
66966
43682
51191
38525
57138
1686
59937
55113
47324
64850
53819
36659
49204
10098
25370
44196
48938
46998
15116
67238
58568
34647
45475
8761
39373
13424
4122
44200
34229
41058
18452
56379
33764
37125
10629
11236
46819
14945
23416
55739
6942
34921
5106
21201
9996
29684
38282
23566
297
66668
68460
14726
40691
39673
18429
23834
6196
52421
67269
12442
63245
49965
14570
34213
64337
25164
48785
49700
4209
5098
9714
7148
4792
20977
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
1001
1002
1003
1004
1005
1006
1007
1008
1009
1010
1011
1012
1013
1014
1015
1016
1017
1018
1019
1020
1021
1022
1023
1024
1025
1026
1027
1028
1029
1030
1031
1032
1033
1034
1035
1036
1037
1038
1039
1040
1041
1042
1043
1044
1045
1046
1047
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
8731
9452
90673
64061
10276
492311
58191
56342
79156
9804
5955
140739
6224
5411
387882
115
4927
285172
3978
8876
1368
54507
137872
115825
91689
3267
57570
65983
51747
9314
6636
84695
25849
55833
84898
1669
1545
5092
5226
54663
3189
84513
4790
54432
221078
10871
57552
10663
6279
56911
79664
5037
115123
55922
755
6767
84719
4673
81793
10949
8707
84881
27440
64794
51765
705
117289
26520
55170
2043
4215
2012
57665
29883
706
6208
6988
9638
284029
64852
54838
9451
2531
118980
10056
55568
23556
517
4094
308
388566
8115
7019
10451
116225
3904
7433
9580
285195
112840
25983
56474
171568
58486
7322
57171
55720
10228
56922
23231
131616
26253
30815
83666
7076
257240
158248
6452
1192
7443
6283
54331
9679
25797
7818
642
8357
51650
83442
79932
27065
54796
91662
5294
375341
7057
55178
2530
1608
80018
6583
163486
607
334
55640
81552
51495
8291
8192
83937
RNMT
ITM2A
PPP1R3E
TSPYL2
NET1
IGIP
CXCL16
PPAN
PLEKHF1
TOMM20
RCN2
UBE2F
RPS20
PNN
C12orf75
ADCY9
NUP88
FAM126B
LIG1
VNN1
CPM
ADAMTSL4
ADHFE1
WDFY2
C22orf32
AGFG1
TRMT5
GRAMD3
LUC7L3
KLF4
SNRPF
LOXL3
PARM1
UBAP2
PLXDC2
DEFA4
CYP1B1
PCBD1
PGD
WDR74
HNRNPH3
PPAPDC1B
NFKB1
YIPF1
NSUN6
CD300C
NCEH1
CXCR6
S100A8
C21orf7
NARG2
PEBP1
MARCH3
NKRF
C21orf2
ST13
LINC00260
NAP1L1
TLR10
HNRNPA0
B3GALT2
RPUSD4
CECR5
DDX31
MST4
BYSL
TAGAP
TIMM9
PRMT6
EPHA4
MAP3K3
EMP1
RDH14
CNOT7
TSPO
RPS14
TCTA
FEZ1
LINC00324
TUT1
WBP1L
EIF2AK3
KDSR
SFXN2
FARSB
GALNT10
PIGN
ATP5G2
MAF
ANXA5
ZNF470
TCL1A
TFAM
VAV3
ZMYND19
LAIR2
VIPR1
SOX13
SLC9A9
WDR89
NGDN
CTPS2
POLR3H
ZBED5
UBE2D2
DOLPP1
TSR1
STX6
MCCC1
SEL1L3
TMEM42
CLEC4E
ST6GALNAC6
PARP9
TIMP1
KLHL34
TTC16
SH3BP2
CLIC1
VRK1
S100A12
GNG2
FAM53B
QPCT
DAP3
BLMH
HIST1H3H
MRPS33
SH3BGRL3
KIAA0319L
NSG1
BNC2
NLRP12
PIK3CG
C3orf62
THBS1
RNMTL1
FUT8
DGKG
NAA25
SLC22A4
DENND1B BCL9
APLP2
FLVCR2
VOPP1
PTPLAD1
DYSF
CLPP
RASSF4
---------------+
---------------++++++
-----++-+++
----------+++++----------++-+++
++-+-+
-----++++++
-----++++++
+++-++
++++++
++-+++
+++-++
------+++++
--++----+---+--+-++++
-----++++++
--------?-+-++-+
++++++
+-++++
++++++
++++++
-------+----------?-+++-++
--+-+++++++
+-++++
-----++++++
--+?+--------?------------------+--++++++
-------------------------+
-----+
-------+-------+
++++++
---------------++++-+
++++++
-------+--++++++
-----++++++
++++++
++++++
-----++++++
--+----------------+++++++
----------++-++++++++
--------?------+++-++
-----++-+++
-----+++?-+
++++++
--+---------------?----?-----------+
---+--+++++
----------------+++++
++-+++
++++++
++-+++
---+-++++++
++++++
++++++
--+--++++++
++++++
++-+++
++++++
-----+
---?--+--------++-+++
-+++++
-----+-++++
++++-+
++++++
++++++
+++++---+------++++-+
-----++++++
+++++-----++++++
++++++
++++++
-----++++++
-----++++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-6.743
-6.903
-6.628
-7.764
-5.491
-7.441
7.114
-5.177
6.040
-6.476
-6.132
5.787
-6.763
-6.648
5.684
5.287
-7.789
5.959
-6.340
6.594
6.028
6.275
5.251
5.890
-7.499
5.550
-5.784
-5.708
-6.367
8.013
-6.134
6.740
-5.594
-6.383
7.161
8.090
6.571
5.951
7.073
-5.934
-5.555
-5.879
-8.120
5.496
-5.471
5.922
5.918
-6.183
6.857
-5.474
-6.451
-4.706
-5.848
-7.186
-5.722
-7.503
5.450
-7.298
-6.695
-6.606
-5.655
-5.809
-6.300
-7.160
-6.872
-4.707
6.637
-4.984
-6.269
-7.993
5.532
6.380
-6.683
-6.538
7.856
-7.257
6.188
7.247
5.275
-5.838
7.095
-6.189
-7.228
-6.375
-6.354
7.121
-6.654
-5.707
5.482
7.511
-6.487
-6.797
-6.354
4.958
-6.510
5.228
-5.554
5.174
7.604
-5.634
-6.177
-6.085
-5.727
-7.425
-6.551
-5.018
-6.958
6.506
-7.759
-7.495
-6.867
6.827
5.049
6.907
5.626
-5.739
5.983
6.605
6.916
-5.169
7.187
6.658
6.873
7.521
-5.923
-5.591
-5.663
-7.040
6.540
7.248
-7.218
6.484
5.858
6.956
5.656
6.628
-4.901
-6.680
5.162
-7.566
5.500
5.206
-6.361
6.366
6.874
7.492
-6.426
6.383
-4.784
6.241
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.56E-11
5.08E-12
3.41E-11
8.23E-15
3.99E-08
9.96E-14
1.13E-12
2.26E-07
1.54E-09
9.45E-11
8.69E-10
7.15E-09
1.35E-11
2.96E-11
1.32E-08
1.24E-07
6.75E-15
2.54E-09
2.29E-10
4.27E-11
1.66E-09
3.49E-10
1.52E-07
3.86E-09
6.44E-14
2.86E-08
7.30E-09
1.15E-08
1.93E-10
1.12E-15
8.57E-10
1.58E-11
2.22E-08
1.74E-10
7.98E-13
5.96E-16
5.00E-11
2.66E-09
1.52E-12
2.96E-09
2.78E-08
4.13E-09
4.66E-16
3.88E-08
4.49E-08
3.19E-09
3.27E-09
6.29E-10
7.04E-12
4.39E-08
1.11E-10
2.52E-06
4.98E-09
6.66E-13
1.05E-08
6.23E-14
5.04E-08
2.91E-13
2.16E-11
3.94E-11
1.56E-08
6.30E-09
2.98E-10
8.06E-13
6.35E-12
2.52E-06
3.21E-11
6.24E-07
3.64E-10
1.32E-15
3.17E-08
1.77E-10
2.34E-11
6.24E-11
3.97E-15
3.95E-13
6.08E-10
4.27E-13
1.33E-07
5.29E-09
1.29E-12
6.04E-10
4.89E-13
1.83E-10
2.10E-10
1.07E-12
2.86E-11
1.15E-08
4.20E-08
5.88E-14
8.76E-11
1.07E-11
2.10E-10
7.14E-07
7.52E-11
1.71E-07
2.79E-08
2.29E-07
2.88E-14
1.76E-08
6.55E-10
1.17E-09
1.02E-08
1.13E-13
5.72E-11
5.23E-07
3.46E-12
7.71E-11
8.59E-15
6.62E-14
6.54E-12
8.69E-12
4.44E-07
4.95E-12
1.84E-08
9.52E-09
2.19E-09
3.98E-11
4.65E-12
2.35E-07
6.64E-13
2.77E-11
6.29E-12
5.45E-14
3.16E-09
2.26E-08
1.49E-08
1.93E-12
6.16E-11
4.22E-13
5.27E-13
8.93E-11
4.69E-09
3.50E-12
1.55E-08
3.40E-11
9.54E-07
2.39E-11
2.45E-07
3.84E-14
3.81E-08
1.93E-07
2.01E-10
1.94E-10
6.24E-12
6.76E-14
1.31E-10
1.73E-10
1.72E-06
4.35E-10
-------------------+-+
---+-+---------------++++++++
-------++++++++
--------------++++--++
---+--------+--++-++++
+++++??+
---+---+++--+++
-----+-+++-++++
++++-+++
++++++++
++++-+++
++++++++
--------++-++++
------------+---+----++++--++
--+----++++++++
---++---+---+-+++-++-+
++++++-+
+++++-++
++++++++
++++++++
-----------------++-+-------+
+++-++++
--+----+++++-++
+++++-++
+------++++--++
-------?--?+??---+----+-+-+-?
------------------+--++-+++++
---+----+------------+
+--+--?-------------------+?---+----------++++-+-+
------------+--+-----++++++++
++++--++
--------------+++++-++
-------++++++++
++++++++
+++++-++
-------++++++++
----------+---+---+???+--???++-+-+++
----+-------+-++++++++
++++++++
+---------+--+--+-----++++-++
-------++++++++
-----+-++++++++
-+++-+++
?++?+??-----------+-----+----+--------+-----------+-----+++-+-++
--------+-+---+
-------+++-++++
++++++++
++++-+++
++-++-++
---?-??+++-++++
++++++++
++++++++
-------+-+++-++
-++--+-+
-+++++++
+++-++-+
-----------------------+----++++++++
-++++--+
---+---?--?+??+
+++-++++
+-++++++
++++++++
++-++--+
----+-------+?+-+++??+
-------++++++++
++++++++
-------+-++++++
++++++++
-+---+-+
-------+++-++++
----+--++++++++
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5004
8009
4829
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
5242
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5004
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5004
8009
8009
8009
8009
8009
6552
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
-5.96
-5.81
-6.07
-4.99
-7.15
-5.29
5.59
-7.42
6.60
-6.17
-6.49
6.82
-5.88
-5.98
6.89
7.38
-4.88
6.62
-6.25
6.01
6.55
6.29
7.26
6.65
-5.11
6.96
-6.73
-6.79
-6.16
4.58
-6.37
5.79
-6.88
-6.15
5.38
4.49
5.93
6.52
5.45
-6.53
-6.89
-6.58
-4.57
6.92
-6.93
6.50
6.48
-6.22
5.57
-6.85
-5.93
-7.53
-6.67
-5.23
-6.62
-4.92
6.86
-5.09
-5.66
-5.73
-6.68
-6.48
-6.00
-5.08
-5.46
-7.52
5.68
-7.25
-6.02
-4.36
6.70
5.89
-5.59
-5.73
4.46
-5.02
6.04
5.03
6.89
-6.35
5.15
-6.01
-5.02
-5.79
-5.82
5.10
-5.55
-6.44
6.66
4.72
-5.69
-5.45
-5.81
7.14
-5.65
6.86
-6.55
6.87
4.59
-6.62
-5.93
-6.02
-6.34
-4.83
-5.55
-7.00
-5.15
5.58
-4.37
-4.62
-5.21
5.25
6.94
5.17
6.38
-6.31
6.02
5.43
5.13
-6.79
4.86
5.35
5.15
4.53
-6.04
-6.34
-6.28
-4.96
5.43
4.75
-4.78
5.40
6.07
5.02
6.25
5.32
-6.96
-5.18
6.80
-4.41
6.37
6.65
-5.54
5.51
5.03
4.43
-5.44
5.48
-7.00
5.61
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2.50E-09
6.36E-09
1.29E-09
6.15E-07
8.77E-13
1.22E-07
2.26E-08
1.15E-13
4.19E-11
6.85E-10
8.45E-11
9.40E-12
4.12E-09
2.27E-09
5.43E-12
1.54E-13
1.09E-06
3.70E-11
4.07E-10
1.86E-09
5.97E-11
3.19E-10
3.88E-13
3.03E-11
3.27E-07
3.46E-12
1.72E-11
1.16E-11
7.45E-10
4.56E-06
1.90E-10
7.04E-09
6.10E-12
7.94E-10
7.44E-08
6.99E-06
2.96E-09
6.89E-11
5.02E-08
6.50E-11
5.63E-12
4.76E-11
4.82E-06
4.55E-12
4.28E-12
8.13E-11
9.10E-11
5.08E-10
2.59E-08
7.19E-12
2.95E-09
5.14E-14
2.55E-11
1.66E-07
3.56E-11
8.51E-07
6.88E-12
3.52E-07
1.54E-08
1.01E-08
2.41E-11
9.28E-11
1.94E-09
3.74E-07
4.85E-08
5.61E-14
1.35E-08
4.17E-13
1.71E-09
1.29E-05
2.07E-11
3.99E-09
2.22E-08
1.02E-08
8.17E-06
5.06E-07
1.53E-09
5.00E-07
5.51E-12
2.17E-10
2.62E-07
1.85E-09
5.16E-07
6.97E-09
5.91E-09
3.37E-07
2.95E-08
1.16E-10
2.83E-11
2.38E-06
1.27E-08
4.99E-08
6.16E-09
9.53E-13
1.58E-08
6.94E-12
5.89E-11
6.41E-12
4.48E-06
3.69E-11
3.04E-09
1.79E-09
2.28E-10
1.39E-06
2.79E-08
2.53E-12
2.55E-07
2.41E-08
1.24E-05
3.87E-06
1.85E-07
1.55E-07
3.99E-12
2.39E-07
1.76E-10
2.81E-10
1.71E-09
5.72E-08
2.95E-07
1.14E-11
1.19E-06
8.73E-08
2.65E-07
5.95E-06
1.58E-09
2.32E-10
3.48E-10
7.00E-07
5.70E-08
2.00E-06
1.75E-06
6.76E-08
1.30E-09
5.14E-07
4.13E-10
1.04E-07
3.47E-12
2.17E-07
1.08E-11
1.06E-05
1.88E-10
3.01E-11
3.10E-08
3.55E-08
5.02E-07
9.61E-06
5.32E-08
4.25E-08
2.59E-12
2.03E-08
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13582
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
14385
12261
14385
12086
15266
15266
15266
15266
15266
15266
15266
13809
15266
15266
13809
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13582
12499
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
14385
15266
12261
15266
15266
14385
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13223
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
12261
15266
15266
15266
15266
15266
13809
13582
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
-8.967
-8.966
-8.965
-8.965
-8.964
-8.963
8.954
-8.945
8.943
-8.933
-8.93
8.927
-8.921
-8.913
8.912
8.904
-8.901
8.9
-8.9
8.899
8.896
8.882
8.878
8.874
-8.869
8.866
-8.861
-8.849
-8.849
8.845
-8.843
8.841
-8.838
-8.835
8.835
8.833
8.828
8.828
8.824
-8.822
-8.819
-8.818
-8.818
8.801
-8.789
8.789
8.774
-8.766
8.76
-8.759
-8.754
-8.751
-8.748
-8.746
-8.741
-8.739
8.726
-8.721
-8.713
-8.704
-8.7
-8.697
-8.691
-8.691
-8.69
-8.69
8.69
-8.687
-8.685
-8.67
8.668
8.661
-8.66
-8.656
8.647
-8.643
8.642
8.637
8.629
-8.624
8.621
-8.621
-8.62
-8.612
-8.61
8.605
-8.603
-8.603
8.6
8.596
-8.594
-8.593
-8.591
8.588
-8.583
8.573
-8.571
8.571
8.565
-8.561
-8.553
-8.552
-8.545
-8.544
-8.54
-8.531
-8.53
8.527
-8.515
-8.513
-8.511
8.507
8.506
8.504
8.501
-8.489
8.488
8.485
8.482
-8.48
8.473
8.467
8.467
8.465
-8.456
-8.452
-8.45
-8.447
8.441
8.44
-8.439
8.437
8.433
8.433
8.426
8.423
-8.418
-8.413
8.41
-8.407
8.406
8.403
-8.395
8.382
8.38
8.371
-8.371
8.371
-8.367
8.366
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3.06E-19
3.08E-19
3.10E-19
3.11E-19
3.14E-19
3.17E-19
3.42E-19
3.71E-19
3.79E-19
4.13E-19
4.25E-19
4.39E-19
4.60E-19
4.95E-19
5.02E-19
5.40E-19
5.53E-19
5.57E-19
5.61E-19
5.61E-19
5.77E-19
6.57E-19
6.80E-19
7.05E-19
7.35E-19
7.59E-19
7.93E-19
8.80E-19
8.85E-19
9.15E-19
9.36E-19
9.48E-19
9.73E-19
9.98E-19
1.01E-18
1.02E-18
1.06E-18
1.07E-18
1.10E-18
1.12E-18
1.15E-18
1.17E-18
1.17E-18
1.36E-18
1.50E-18
1.50E-18
1.72E-18
1.86E-18
1.95E-18
1.98E-18
2.06E-18
2.12E-18
2.18E-18
2.22E-18
2.30E-18
2.35E-18
2.63E-18
2.75E-18
2.95E-18
3.19E-18
3.32E-18
3.40E-18
3.58E-18
3.59E-18
3.62E-18
3.64E-18
3.64E-18
3.71E-18
3.79E-18
4.32E-18
4.41E-18
4.67E-18
4.74E-18
4.88E-18
5.27E-18
5.49E-18
5.51E-18
5.77E-18
6.21E-18
6.49E-18
6.61E-18
6.65E-18
6.70E-18
7.17E-18
7.30E-18
7.64E-18
7.74E-18
7.79E-18
7.95E-18
8.27E-18
8.40E-18
8.48E-18
8.64E-18
8.88E-18
9.27E-18
1.01E-17
1.03E-17
1.03E-17
1.08E-17
1.12E-17
1.20E-17
1.21E-17
1.29E-17
1.29E-17
1.35E-17
1.45E-17
1.46E-17
1.50E-17
1.67E-17
1.70E-17
1.72E-17
1.79E-17
1.80E-17
1.83E-17
1.88E-17
2.08E-17
2.11E-17
2.16E-17
2.22E-17
2.24E-17
2.39E-17
2.52E-17
2.53E-17
2.56E-17
2.77E-17
2.87E-17
2.92E-17
2.99E-17
3.16E-17
3.16E-17
3.20E-17
3.27E-17
3.36E-17
3.38E-17
3.58E-17
3.67E-17
3.82E-17
3.98E-17
4.10E-17
4.21E-17
4.24E-17
4.35E-17
4.66E-17
5.23E-17
5.31E-17
5.69E-17
5.71E-17
5.73E-17
5.90E-17
5.97E-17
?
?
+
?
+
+
+
?
?
?
+
+
?
+
?
+
?
?
?
+
?
?
?
?
?
?
+
+
?
+
?
?
+
?
?
?
?
+
?
+
?
?
?
+
+
+
?
?
+
+
?
+
?
+
?
?
?
?
?
+
+
?
?
?
?
+
?
+
?
?
?
?
+
?
+
+
+
+
?
+
+
?
?
+
?
?
?
?
?
+
?
+
?
+
?
?
?
?
?
+
+
+
?
+
+
+
?
?
+
+
0
0
394
0
394
394
394
394
0
394
394
394
0
394
0
394
394
394
394
0
394
0
394
394
0
0
0
394
394
0
394
0
394
0
0
0
0
394
394
394
394
0
394
394
0
0
394
0
0
0
0
394
394
0
394
394
0
394
0
394
0
394
394
394
0
394
0
394
394
394
394
0
394
394
394
394
394
394
0
394
394
0
0
0
0
0
394
394
0
394
0
0
0
394
394
0
394
0
0
0
394
0
394
0
394
394
394
394
394
394
394
0
394
394
0
0
394
0
0
0
0
0
394
0
394
394
0
394
394
394
394
0
0
0
0
0
394
394
394
394
0
394
394
394
0
0
394
394
394
394
ns
ns
0.017
ns
0.003
0.004
-0.003
0.003
ns
-0.004
-0.009
-0.006
ns
-0.005
ns
0.014
-0.004
-0.001
0.014
ns
0.004
ns
0.007
-0.003
ns
ns
ns
0.004
-0.005
ns
-0.003
ns
-0.008
ns
ns
ns
ns
0.003
-0.011
0.014
-0.005
ns
0.012
-0.002
ns
ns
0.008
ns
ns
ns
ns
-0.001
0.003
ns
0.010
-0.004
ns
-0.001
ns
-0.003
ns
0.012
0.000
0.004
ns
-0.005
ns
-0.004
-0.016
0.005
0.011
ns
0.000
-0.005
-0.003
-0.001
-0.001
-0.016
ns
0.009
-0.002
ns
ns
ns
ns
ns
0.003
0.001
ns
-0.008
ns
ns
ns
-0.005
0.005
ns
0.013
ns
ns
ns
0.000
ns
0.003
ns
-0.001
0.000
0.003
0.006
0.012
-0.006
-0.005
ns
0.006
0.001
ns
ns
0.002
ns
ns
ns
ns
ns
0.005
ns
-0.001
0.002
ns
-0.011
-0.007
0.000
0.008
ns
ns
ns
ns
ns
0.004
-0.011
0.012
0.015
ns
0.016
0.013
0.004
ns
ns
-0.006
0.004
-0.007
0.001
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
0.002
ns
0.003
ns
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
ns
0.003
ns
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
ns
ns
ns
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
0.004
ns
0.003
0.003
0.004
0.003
ns
0.003
0.003
0.003
0.003
0.004
0.003
ns
0.003
0.003
ns
ns
ns
ns
ns
0.003
0.003
ns
0.003
ns
ns
ns
0.003
0.003
ns
0.003
ns
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.004
ns
ns
ns
ns
ns
0.003
ns
0.003
0.002
ns
0.003
0.003
0.003
0.003
ns
ns
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.004
ns
ns
0.003
0.004
0.003
0.003
ns
ns
7.75E-08
ns
4.39E-01
1.90E-01
2.89E-01
3.58E-01
ns
1.63E-01
2.26E-03
6.38E-02
ns
8.19E-02
ns
1.04E-05
2.25E-01
8.01E-01
2.24E-08
ns
2.11E-01
ns
2.82E-02
3.93E-01
ns
ns
ns
2.00E-01
1.43E-01
ns
3.31E-01
ns
2.08E-02
ns
ns
ns
ns
2.95E-01
3.22E-04
1.04E-05
9.70E-02
ns
4.56E-05
5.05E-01
ns
ns
1.51E-02
ns
ns
ns
ns
7.48E-01
2.17E-01
ns
2.38E-03
2.34E-01
ns
7.43E-01
ns
3.42E-01
ns
2.64E-04
9.30E-01
2.40E-01
ns
1.27E-01
ns
3.01E-01
2.22E-08
1.50E-01
1.30E-04
ns
9.23E-01
1.06E-01
3.87E-01
8.04E-01
8.06E-01
8.80E-07
ns
2.08E-03
5.96E-01
ns
ns
ns
ns
ns
3.51E-01
7.48E-01
ns
1.13E-02
ns
ns
ns
1.06E-01
8.57E-02
ns
2.92E-05
ns
ns
ns
9.30E-01
ns
3.56E-01
ns
6.65E-01
9.62E-01
3.64E-01
9.54E-02
4.12E-04
6.34E-02
1.18E-01
ns
8.53E-02
8.71E-01
ns
ns
4.92E-01
ns
ns
ns
ns
ns
7.94E-02
ns
7.38E-01
5.14E-01
ns
4.65E-04
3.44E-02
9.14E-01
1.29E-02
ns
ns
ns
ns
ns
1.76E-01
5.22E-05
1.72E-04
1.04E-05
ns
3.42E-07
4.12E-05
2.27E-01
ns
ns
7.30E-02
3.10E-01
4.16E-02
8.42E-01
?
?
+
?
+
+
+
?
?
?
+
+
+
?
?
?
+
?
?
?
?
+
+
?
?
?
?
?
?
+
+
+
?
+
?
?
?
?
?
?
+
+
?
+
+
?
+
?
?
+
+
?
?
?
?
+
+
+
+
?
+
?
?
?
?
?
+
+
?
+
?
?
?
?
+
?
+
+
?
?
+
?
+
+
?
+
?
?
+
?
+
?
?
?
+
+
?
+
?
?
?
?
?
+
+
?
+
+
+
?
?
+
+
0
0
394
0
394
394
394
394
0
394
394
394
0
394
0
394
394
394
394
0
0
0
394
0
0
0
0
394
394
0
394
0
394
0
0
0
0
394
394
394
394
0
394
394
0
0
394
0
0
0
0
394
394
0
394
394
0
394
0
394
0
394
394
394
0
394
0
394
394
394
0
0
394
394
394
394
394
394
0
394
394
0
0
0
0
0
394
394
0
394
0
0
0
0
394
0
394
394
394
0
394
0
394
0
394
394
394
394
394
394
394
0
394
394
0
0
394
0
394
0
0
0
394
394
394
394
0
394
394
394
394
0
0
0
0
0
394
394
394
394
0
394
394
394
0
0
394
394
394
394
ns
ns
0.020
ns
0.001
0.007
-0.001
0.009
ns
-0.009
-0.015
-0.006
ns
-0.002
ns
0.010
0.004
-0.009
0.010
ns
ns
ns
0.011
ns
ns
ns
ns
0.012
0.000
ns
-0.005
ns
-0.004
ns
ns
ns
ns
0.004
0.001
0.015
-0.001
ns
0.012
-0.009
ns
ns
-0.004
ns
ns
ns
ns
0.005
0.003
ns
0.010
0.010
ns
0.005
ns
-0.016
ns
0.011
-0.011
0.004
ns
-0.008
ns
-0.006
-0.017
-0.011
ns
ns
-0.013
-0.012
0.011
0.004
0.006
0.001
ns
0.013
-0.003
ns
ns
ns
ns
ns
0.011
0.004
ns
0.007
ns
ns
ns
ns
0.002
ns
-0.006
0.007
0.007
ns
-0.003
ns
0.008
ns
-0.009
-0.001
0.000
-0.009
0.005
-0.017
-0.001
ns
-0.001
0.009
ns
ns
0.001
ns
0.002
ns
ns
ns
0.014
-0.007
-0.003
0.005
ns
-0.013
-0.006
-0.001
0.004
ns
ns
ns
ns
ns
-0.004
-0.007
0.015
0.003
ns
0.006
0.017
0.007
ns
ns
-0.006
0.017
-0.008
0.009
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
ns
ns
0.003
ns
ns
ns
ns
0.003
0.003
ns
0.003
ns
0.004
ns
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.004
ns
ns
ns
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.004
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.004
ns
ns
ns
ns
ns
0.003
0.003
ns
0.003
ns
ns
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
ns
0.003
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.004
ns
ns
ns
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
ns
1.84E-12
ns
7.14E-01
1.59E-02
8.71E-01
7.15E-03
ns
4.16E-03
9.33E-07
8.07E-02
ns
5.30E-01
ns
3.29E-03
2.37E-01
1.05E-02
6.62E-04
ns
ns
ns
1.21E-03
ns
ns
ns
ns
1.09E-04
8.87E-01
ns
1.00E-01
ns
3.06E-01
ns
ns
ns
ns
2.35E-01
7.70E-01
4.55E-06
6.02E-01
ns
2.10E-04
4.04E-03
ns
ns
2.26E-01
ns
ns
ns
ns
1.27E-01
3.54E-01
ns
2.76E-03
2.42E-03
ns
1.49E-01
ns
4.35E-07
ns
1.12E-03
1.20E-03
3.03E-01
ns
2.02E-02
ns
8.23E-02
7.15E-10
1.76E-03
ns
ns
6.40E-05
5.51E-05
5.77E-04
2.13E-01
7.48E-02
8.29E-01
ns
2.59E-05
3.87E-01
ns
ns
ns
ns
ns
7.86E-04
3.12E-01
ns
2.84E-02
ns
ns
ns
ns
5.63E-01
ns
7.47E-02
2.36E-02
2.21E-02
ns
4.27E-01
ns
2.43E-02
ns
2.92E-03
7.71E-01
8.92E-01
5.73E-03
1.26E-01
1.13E-06
7.49E-01
ns
6.69E-01
2.66E-03
ns
ns
7.22E-01
ns
6.29E-01
ns
ns
ns
9.69E-06
4.78E-02
4.00E-01
6.79E-02
ns
2.12E-05
5.25E-02
7.16E-01
2.20E-01
ns
ns
ns
ns
ns
1.67E-01
2.74E-02
4.18E-07
3.19E-01
ns
4.81E-02
3.07E-08
4.06E-02
ns
ns
7.74E-02
9.93E-09
2.17E-02
8.20E-03
--?
-?
+-+
-+
+?
?+
---+++?
?+
+--?+
+-+
++
---?
-?-?
-+
-?+
?
+-+
?+
?+
++
?++?
++
-+
???+
-?
?+
++
--+?
-?
?+
??
-?++
++
----?
++?--+++
-+++
+-?+
++
?+
--?
?
?++
?-++
?+
-+-+++
-+
-+
++
+-+-?
--+-+--?+
-+
-+
++
+?
-?
++
?+
++
+++
++
++
-+
--?-++
+-+
?+
?+
--?+
-??+
-?
++
?
-+
++
++
++
+++
-?+
515
302
515
0
515
515
515
302
213
515
515
515
515
515
302
213
515
515
515
213
515
515
515
515
515
302
515
213
302
515
515
213
0
515
515
213
213
515
213
515
302
515
515
213
213
213
302
213
515
515
515
515
0
302
213
213
0
515
213
515
515
515
515
515
302
515
515
213
515
515
515
515
515
515
515
515
515
213
515
213
515
515
0
0
213
515
213
515
515
213
515
515
515
515
515
515
515
515
515
515
515
302
515
515
515
515
515
515
515
213
515
515
515
515
0
302
515
213
515
515
515
515
515
515
515
515
213
515
515
515
515
213
213
515
515
213
515
213
213
302
515
0
515
515
515
515
515
515
515
213
-1.329
-0.803
-0.810
ns
-1.004
-0.613
-0.885
0.966
0.882
-1.642
-0.715
-1.727
0.260
-0.604
1.699
2.080
-0.529
-1.743
-1.120
0.915
-0.541
-0.133
2.651
-2.344
-1.645
-1.457
-0.569
-2.121
-1.136
0.816
-0.855
2.061
ns
-1.480
0.207
0.417
3.400
2.203
-2.428
-1.245
0.180
2.935
-0.894
-1.245
-1.809
2.501
-1.559
1.576
1.530
-0.935
-1.127
-0.058
ns
-0.510
1.320
-1.884
ns
-0.534
-1.074
1.386
1.303
-1.433
-0.754
-2.424
-3.713
-0.296
0.780
-1.491
-2.622
-1.168
-0.135
2.240
-2.837
-0.086
2.861
-1.395
-2.315
1.506
0.891
0.242
-0.397
-2.032
ns
ns
-1.865
1.665
-2.287
-1.018
3.939
3.936
-0.424
-0.021
-2.572
0.111
0.676
0.315
0.237
3.374
1.675
-0.906
-1.168
-2.151
-1.568
-1.293
-2.221
-1.202
-0.290
-2.671
-2.104
2.556
-0.133
0.388
2.443
1.029
ns
-1.369
3.481
3.031
5.138
-0.525
1.422
0.756
2.777
0.605
-1.850
-2.160
-0.388
-0.712
2.727
-1.604
1.643
0.497
1.440
-1.252
-0.649
0.542
-1.863
-1.071
0.282
-2.772
1.294
ns
-0.578
1.250
2.703
1.232
-0.792
0.714
-0.862
2.336
1.84E-01
4.22E-01
4.18E-01
ns
3.16E-01
5.40E-01
3.76E-01
3.34E-01
3.78E-01
1.01E-01
4.75E-01
8.42E-02
7.95E-01
5.46E-01
8.93E-02
3.75E-02
5.97E-01
8.14E-02
2.63E-01
3.60E-01
5.89E-01
8.95E-01
8.02E-03
1.91E-02
1.00E-01
1.45E-01
5.70E-01
3.39E-02
2.56E-01
4.14E-01
3.92E-01
3.93E-02
ns
1.39E-01
8.36E-01
6.77E-01
6.75E-04
2.76E-02
1.52E-02
2.13E-01
8.57E-01
3.33E-03
3.71E-01
2.13E-01
7.04E-02
1.24E-02
1.19E-01
1.15E-01
1.26E-01
3.50E-01
2.60E-01
9.54E-01
ns
6.10E-01
1.87E-01
5.96E-02
ns
5.94E-01
2.83E-01
1.66E-01
1.93E-01
1.52E-01
4.51E-01
1.53E-02
2.05E-04
7.67E-01
4.35E-01
1.36E-01
8.73E-03
2.43E-01
8.93E-01
2.51E-02
4.56E-03
9.32E-01
4.23E-03
1.63E-01
2.06E-02
1.32E-01
3.73E-01
8.09E-01
6.91E-01
4.22E-02
ns
ns
6.22E-02
9.59E-02
2.22E-02
3.09E-01
8.19E-05
8.29E-05
6.72E-01
9.83E-01
1.01E-02
9.12E-01
4.99E-01
7.52E-01
8.13E-01
7.41E-04
9.40E-02
3.65E-01
2.43E-01
3.15E-02
1.17E-01
1.96E-01
2.64E-02
2.30E-01
7.72E-01
7.57E-03
3.54E-02
1.06E-02
8.95E-01
6.98E-01
1.46E-02
3.03E-01
ns
1.71E-01
5.01E-04
2.44E-03
2.77E-07
6.00E-01
1.55E-01
4.50E-01
5.49E-03
5.45E-01
6.43E-02
3.07E-02
6.98E-01
4.76E-01
6.38E-03
1.09E-01
1.00E-01
6.19E-01
1.50E-01
2.11E-01
5.16E-01
5.88E-01
6.25E-02
2.84E-01
7.78E-01
5.57E-03
1.96E-01
ns
5.63E-01
2.11E-01
6.88E-03
2.18E-01
4.29E-01
4.75E-01
3.89E-01
1.95E-02
+
?
+
?
+
+
+
+
?
+
+
+
+
?
+
?
?
+
+
+
?
?
?
?
?
+
?
?
?
?
?
+
?
+
+
+
+
+
+
+
?
?
?
?
+
?
+
?
+
+
+
+
+
?
?
+
+
+
?
?
+
?
+
+
+
+
+
?
+
+
?
+
+
+
?
?
?
+
?
+
+
+
+
+
299
299
299
0
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
0
299
299
299
0
0
299
299
299
299
299
0
299
299
299
299
0
0
0
299
0
299
299
299
299
0
299
0
0
0
299
0
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
0
299
299
0
0
0
299
0
299
299
0
299
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
0
299
299
299
299
0
0
299
0
299
299
299
299
299
299
299
299
0
299
299
299
299
0
299
299
299
0
299
0
0
299
299
0
299
299
299
299
299
299
299
299
-0.010
0.001
-0.031
ns
-0.003
-0.006
0.015
-0.003
ns
-0.024
-0.010
0.012
-0.005
-0.008
0.019
0.001
-0.003
0.004
-0.009
ns
0.013
0.003
0.006
-0.010
-0.019
0.002
-0.014
ns
-0.026
0.022
-0.022
ns
ns
-0.001
0.005
0.006
0.001
-0.001
ns
-0.001
-0.011
-0.001
-0.025
ns
ns
ns
-0.001
ns
0.050
-0.003
-0.004
-0.008
ns
-0.014
ns
ns
ns
-0.022
ns
-0.009
-0.002
-0.010
-0.024
-0.012
-0.016
-0.004
0.008
ns
-0.007
0.003
0.007
0.005
-0.023
-0.010
0.025
-0.018
0.000
0.005
0.000
ns
-0.001
-0.007
ns
ns
ns
0.008
ns
-0.023
0.006
ns
-0.004
0.000
-0.020
0.020
-0.002
0.008
-0.024
0.019
0.003
ns
-0.002
-0.017
-0.005
-0.023
-0.002
-0.004
-0.001
-0.008
-0.010
ns
-0.009
0.005
0.008
0.008
ns
ns
0.019
ns
0.030
-0.006
0.032
0.008
0.018
0.008
-0.021
-0.004
ns
-0.016
0.011
0.001
-0.015
ns
0.001
0.003
0.002
ns
-0.008
ns
ns
-0.007
0.003
ns
-0.003
0.007
0.000
0.001
-0.009
0.007
-0.003
0.015
0.005
0.010
0.005
ns
0.004
0.003
0.010
0.003
ns
0.009
0.008
0.004
0.005
0.005
0.010
0.002
0.004
0.004
0.004
ns
0.005
0.002
0.005
0.004
0.005
0.008
0.007
ns
0.009
0.012
0.007
ns
ns
0.003
0.003
0.006
0.002
0.002
ns
0.009
0.007
0.003
0.006
ns
ns
ns
0.002
ns
0.020
0.005
0.002
0.004
ns
0.003
ns
ns
ns
0.008
ns
0.005
0.002
0.004
0.005
0.004
0.005
0.002
0.009
ns
0.003
0.004
0.003
0.002
0.005
0.007
0.006
0.005
0.004
0.004
0.003
ns
0.002
0.006
ns
ns
ns
0.005
ns
0.006
0.008
ns
0.002
0.002
0.006
0.005
0.004
0.010
0.009
0.005
0.004
ns
0.006
0.004
0.003
0.007
0.002
0.002
0.003
0.003
0.003
ns
0.004
0.003
0.005
0.005
ns
ns
0.006
ns
0.007
0.004
0.014
0.010
0.006
0.007
0.004
0.004
ns
0.004
0.006
0.002
0.009
ns
0.002
0.005
0.003
ns
0.005
ns
ns
0.003
0.002
ns
0.003
0.004
0.003
0.002
0.005
0.008
0.004
0.004
6.58E-02
9.00E-01
4.91E-09
ns
4.95E-01
2.69E-02
1.25E-01
3.01E-01
ns
1.11E-02
2.26E-01
1.06E-02
2.88E-01
1.58E-01
6.24E-02
7.64E-01
4.69E-01
3.65E-01
3.45E-02
ns
1.68E-02
1.22E-01
2.53E-01
4.37E-03
1.44E-04
7.71E-01
4.08E-02
ns
3.66E-03
7.62E-02
4.04E-03
ns
ns
7.84E-01
1.37E-01
2.88E-01
7.99E-01
6.71E-01
ns
9.10E-01
9.18E-02
7.16E-01
2.74E-05
ns
ns
ns
6.12E-01
ns
1.21E-02
5.48E-01
7.83E-02
4.04E-02
ns
1.95E-05
ns
ns
ns
6.75E-03
ns
3.86E-02
3.08E-01
1.01E-02
1.14E-05
2.81E-03
1.19E-03
1.93E-02
4.08E-01
ns
1.17E-02
4.55E-01
2.79E-02
4.81E-02
1.64E-06
1.58E-01
4.11E-05
8.96E-04
9.72E-01
1.82E-01
9.50E-01
ns
4.67E-01
2.65E-01
ns
ns
ns
9.49E-02
ns
7.03E-05
4.24E-01
ns
7.78E-02
9.86E-01
1.70E-03
3.81E-05
6.71E-01
4.35E-01
7.55E-03
3.90E-05
4.86E-01
ns
6.69E-01
1.76E-05
1.21E-01
1.61E-03
4.14E-01
8.84E-02
6.97E-01
1.40E-02
3.30E-03
ns
1.63E-02
1.11E-01
7.85E-02
1.06E-01
ns
ns
1.07E-03
ns
1.76E-05
1.93E-01
2.74E-02
3.82E-01
3.88E-03
2.60E-01
3.35E-06
3.16E-01
ns
5.19E-05
5.11E-02
5.01E-01
1.22E-01
ns
6.97E-01
4.62E-01
5.71E-01
ns
1.06E-01
ns
ns
4.40E-02
1.92E-01
ns
3.62E-01
8.72E-02
8.76E-01
8.28E-01
8.35E-02
3.92E-01
4.52E-01
3.72E-05
-+
?-+
?+
-+
+?
++
?+-----+
?-+
--+
-+
-+
-+
++
-+
-+
-?
?+
--?+
-+
--+
?
-+
-+
+++
--+
-+
?+
+-+
--+
-?+
+?
--?
--?
?+?
-?+
--++
+?
---?--+
--+-+
++-++
-++
++
-?
++
-?
-??
-?
-+
--++
-+
----+
++
+++
+-+
-+
-?-+
-+
-+-+
-+
-++
+-+
+-+
?+
?
+++
+--++
++
---+
+-++
-+
++?
-+
-+
-?
++
+--?
-?
-+
-+
++
++
-++
+-+
567
354
567
354
567
213
567
354
567
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
213
354
567
567
354
567
567
567
0
567
567
567
567
567
567
567
354
567
567
567
567
567
354
213
567
213
567
567
0
354
213
567
354
567
567
567
213
567
567
567
354
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
213
567
354
0
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
567
567
567
354
0
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
213
567
567
567
567
0
567
0
567
567
567
567
567
567
567
567
1.055
-1.931
-0.884
0.434
2.100
0.029
4.882
-0.122
1.014
-3.851
-3.215
-2.785
-1.783
0.667
-1.499
0.842
-4.856
-0.217
0.262
0.564
-0.055
4.484
0.154
1.151
-0.843
2.387
-3.032
-0.814
3.424
0.979
-4.182
1.368
ns
-0.364
0.282
-0.052
1.169
-1.116
-0.392
-1.543
0.827
0.353
0.527
-2.099
-0.880
-0.598
0.731
1.208
-0.743
-2.151
-1.979
-3.523
ns
-3.000
1.491
-4.038
0.465
-3.257
-2.791
1.744
0.335
-1.799
-1.763
-1.547
-2.136
-4.179
0.588
-3.753
-0.775
-0.197
1.231
0.741
-0.379
-3.120
0.941
-4.750
0.703
1.894
-0.933
0.989
-0.210
-1.400
-0.035
ns
-2.729
2.378
-3.522
-2.073
1.329
1.106
-1.149
-2.302
-2.860
1.989
0.920
0.565
2.095
0.522
-0.765
0.577
-1.631
-0.829
1.210
0.722
-1.500
-1.047
-1.492
1.046
-3.741
1.421
-0.877
1.105
-0.852
0.233
4.339
ns
1.046
1.132
-0.238
-2.918
-1.915
1.557
2.009
-1.938
-2.377
-0.895
-1.326
-4.828
2.215
-0.080
0.318
2.503
2.091
2.332
-0.898
3.055
-2.482
-2.379
-2.450
ns
-2.015
ns
0.221
-0.135
1.322
0.740
-2.025
3.433
-2.344
-0.538
2.91E-01
5.35E-02
3.77E-01
6.64E-01
3.57E-02
9.77E-01
1.05E-06
9.03E-01
3.11E-01
1.18E-04
1.31E-03
5.36E-03
7.46E-02
5.05E-01
1.34E-01
4.00E-01
1.20E-06
8.28E-01
7.93E-01
5.73E-01
9.56E-01
7.34E-06
8.77E-01
2.50E-01
3.99E-01
1.70E-02
2.43E-03
4.16E-01
6.18E-04
3.28E-01
2.89E-05
1.71E-01
ns
7.16E-01
7.78E-01
9.59E-01
2.42E-01
2.65E-01
6.95E-01
1.23E-01
4.08E-01
7.24E-01
5.98E-01
3.58E-02
3.79E-01
5.50E-01
4.65E-01
2.27E-01
4.57E-01
3.15E-02
4.78E-02
4.26E-04
ns
2.70E-03
1.36E-01
5.40E-05
6.42E-01
1.13E-03
5.26E-03
8.12E-02
7.38E-01
7.20E-02
7.79E-02
1.22E-01
3.27E-02
2.93E-05
5.57E-01
1.74E-04
4.39E-01
8.44E-01
2.18E-01
4.59E-01
7.05E-01
1.81E-03
3.47E-01
2.03E-06
4.82E-01
5.83E-02
3.51E-01
3.23E-01
8.34E-01
1.61E-01
9.72E-01
ns
6.35E-03
1.74E-02
4.29E-04
3.81E-02
1.84E-01
2.69E-01
2.51E-01
2.14E-02
4.24E-03
4.67E-02
3.58E-01
5.72E-01
3.62E-02
6.02E-01
4.44E-01
5.64E-01
1.03E-01
4.07E-01
2.26E-01
4.71E-01
1.34E-01
2.95E-01
1.36E-01
2.95E-01
1.83E-04
1.55E-01
3.81E-01
2.69E-01
3.94E-01
8.16E-01
1.43E-05
ns
2.96E-01
2.58E-01
8.12E-01
3.52E-03
5.55E-02
1.19E-01
4.45E-02
5.26E-02
1.75E-02
3.71E-01
1.85E-01
1.38E-06
2.68E-02
9.36E-01
7.51E-01
1.23E-02
3.65E-02
1.97E-02
3.69E-01
2.25E-03
1.31E-02
1.74E-02
1.43E-02
ns
4.40E-02
ns
8.25E-01
8.93E-01
1.86E-01
4.59E-01
4.29E-02
5.96E-04
1.91E-02
5.90E-01
+
+
?
+
+
+
+
?
+
+
+
+
+
?
+
+
?
+
+
?
+
+
?
+
+
+
?
+
+
+
?
+
+
+
?
+
+
?
+
+
+
?
+
+
+
?
+
+
+
+
?
?
+
+
+
?
+
+
+
+
?
+
+
+
+
+
+
+
?
+
+
?
+
+
+
+
+
+
+
?
+
+
+
+
+
+
?
?
?
+
+
?
?
-
869
869
869
869
0
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
0
869
869
0
869
869
869
0
869
869
0
869
869
869
869
0
869
869
869
869
869
0
869
869
869
869
869
0
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
0
0
869
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
0
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
0
0
0
869
869
869
869
0
0
869
869
-0.002
-0.003
0.002
0.001
ns
-0.002
-0.001
0.002
-0.001
-0.001
0.003
0.001
-0.005
0.001
ns
0.000
0.002
0.002
0.003
-0.001
-0.005
0.000
-0.007
0.001
-0.001
ns
0.000
0.002
ns
0.000
0.003
0.001
ns
0.003
0.002
ns
-0.005
0.001
0.002
0.002
ns
-0.002
-0.002
0.001
0.001
0.000
ns
-0.001
0.000
-0.001
0.001
0.001
ns
0.001
0.000
0.001
ns
-0.001
-0.005
0.003
-0.001
0.000
0.001
0.001
-0.001
ns
-0.002
0.001
0.002
-0.001
0.002
ns
0.000
0.002
-0.004
0.003
0.002
-0.007
-0.001
0.002
0.000
-0.002
ns
ns
0.003
-0.001
0.003
0.003
ns
-0.001
-0.004
0.002
0.003
-0.002
0.001
-0.005
0.000
ns
0.002
0.000
-0.002
-0.002
0.006
-0.001
0.003
0.003
0.001
-0.003
0.001
-0.005
-0.002
0.001
-0.003
0.000
0.000
0.000
ns
-0.003
0.002
0.002
ns
-0.001
0.002
0.001
0.000
0.002
0.004
0.001
0.003
-0.002
-0.003
ns
-0.001
0.006
0.005
0.005
0.001
0.003
0.000
ns
ns
ns
0.004
-0.002
-0.005
0.001
ns
ns
0.000
-0.004
0.001
0.002
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.002
0.002
0.002
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.003
0.001
0.002
0.001
0.001
ns
0.001
0.002
ns
0.000
0.001
0.002
ns
0.001
0.005
ns
0.004
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.002
0.001
0.001
ns
0.001
0.000
0.001
ns
0.002
0.002
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.001
ns
ns
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.003
0.001
0.001
0.001
0.002
0.000
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.002
0.002
0.001
ns
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.003
ns
0.001
0.002
0.001
0.002
0.001
0.002
0.001
ns
ns
ns
0.001
0.001
0.002
0.001
ns
ns
0.001
0.003
9.81E-02
2.26E-01
4.89E-02
4.28E-01
ns
1.30E-01
1.39E-01
1.27E-02
1.79E-01
4.50E-01
8.37E-02
3.39E-01
4.29E-06
1.48E-01
ns
8.53E-01
4.43E-02
8.30E-02
3.19E-04
4.44E-01
1.29E-01
9.18E-01
2.66E-05
4.27E-01
1.61E-01
ns
7.03E-01
3.88E-01
ns
8.26E-01
2.10E-02
6.49E-01
ns
9.10E-05
6.74E-01
ns
2.02E-01
4.22E-01
6.73E-02
4.06E-02
ns
8.36E-02
3.48E-02
1.41E-01
1.83E-01
9.70E-01
ns
1.44E-01
8.28E-01
6.00E-01
3.40E-01
4.98E-01
ns
4.78E-01
1.99E-01
1.61E-01
ns
6.18E-01
5.55E-04
4.50E-03
1.03E-01
8.23E-01
1.89E-01
8.97E-02
1.23E-01
ns
1.06E-01
3.81E-01
1.88E-01
7.21E-01
1.75E-02
ns
7.91E-01
5.06E-02
1.01E-02
5.29E-02
2.72E-02
1.49E-02
2.06E-01
7.94E-05
8.59E-01
1.61E-01
ns
ns
1.51E-03
3.56E-01
2.69E-02
2.79E-04
ns
2.85E-01
8.14E-04
3.66E-01
3.94E-03
1.32E-01
1.13E-01
2.34E-02
6.93E-01
ns
9.64E-02
8.15E-01
2.14E-01
1.52E-01
4.55E-05
2.99E-01
6.61E-03
3.48E-05
2.56E-01
1.11E-02
6.39E-01
1.12E-01
2.77E-02
2.79E-01
4.84E-04
8.61E-01
8.11E-01
4.61E-01
ns
1.68E-03
6.74E-03
1.49E-01
ns
5.13E-01
6.00E-02
1.29E-01
9.86E-01
8.21E-02
8.26E-04
6.06E-01
6.04E-05
4.85E-02
2.57E-01
ns
6.84E-02
9.81E-03
4.45E-04
1.03E-02
2.09E-01
7.69E-02
6.99E-01
ns
ns
ns
4.35E-05
1.31E-01
2.53E-03
3.29E-01
ns
ns
9.26E-01
1.39E-01
?
?
?
?
?
?
?
?
+
?
?
?
?
?
?
?
+
?
?
?
?
+
?
?
+
?
+
?
+
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
?
+
?
+
?
?
?
?
+
+
?
?
?
?
+
?
?
?
+
?
?
?
?
?
+
+
?
?
?
?
?
?
?
?
?
?
?
?
+
+
?
?
+
?
?
?
?
?
?
?
?
?
?
?
+
+
+
?
?
?
+
?
?
+
?
?
+
?
?
1244
0
0
0
0
0
0
0
0
1244
1244
1244
1244
0
0
0
1244
0
1244
1244
0
0
0
1244
1244
1244
0
1244
0
0
0
1244
0
0
1244
0
1244
0
1244
0
0
1244
1244
0
1244
0
0
1244
1244
1244
0
1244
0
0
1244
1244
0
0
0
0
1244
1244
0
1244
0
0
1244
1244
1244
1244
0
1244
1244
0
0
0
0
1244
1244
1244
0
0
0
1244
0
1244
0
0
0
1244
0
0
0
0
1244
0
1244
1244
1244
0
0
0
0
0
0
0
0
0
0
0
1244
0
1244
1244
0
0
1244
0
0
0
1244
0
0
0
0
1244
1244
0
0
1244
0
0
1244
1244
1244
1244
1244
0
0
1244
0
1244
0
0
1244
0
0
1244
0
0
-0.001
ns
ns
ns
ns
ns
ns
ns
ns
-0.001
-0.001
0.002
-0.002
ns
ns
ns
-0.002
ns
-0.001
0.000
ns
ns
ns
0.000
-0.001
0.000
ns
-0.002
ns
ns
ns
0.000
ns
ns
0.000
ns
0.001
ns
0.000
ns
ns
0.000
-0.002
ns
-0.002
ns
ns
-0.001
0.000
-0.002
ns
-0.003
ns
ns
-0.001
-0.002
ns
ns
ns
ns
0.000
-0.001
ns
-0.001
ns
ns
0.002
-0.002
-0.001
0.000
ns
0.001
-0.001
ns
ns
ns
ns
0.001
0.001
-0.002
ns
ns
ns
-0.002
ns
0.000
ns
ns
ns
0.002
ns
ns
ns
ns
0.000
ns
-0.003
0.002
0.001
ns
ns
ns
ns
ns
ns
ns
ns
ns
ns
ns
-0.001
ns
0.002
0.001
ns
ns
0.004
ns
ns
ns
0.000
ns
ns
ns
ns
-0.002
-0.001
ns
ns
0.000
ns
ns
0.000
0.002
0.000
0.003
0.000
ns
ns
0.000
ns
0.001
ns
ns
0.001
ns
ns
0.001
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
0.000
0.000
0.000
0.001
ns
ns
ns
0.000
ns
0.000
0.001
ns
ns
ns
0.000
0.000
0.000
ns
0.000
ns
ns
ns
0.000
ns
ns
0.000
ns
0.001
ns
0.001
ns
ns
0.000
0.000
ns
0.000
ns
ns
0.000
0.001
0.001
ns
0.001
ns
ns
0.000
0.000
ns
ns
ns
ns
0.000
0.000
ns
0.000
ns
ns
0.001
0.000
0.000
0.000
ns
0.000
0.000
ns
ns
ns
ns
0.000
0.000
0.000
ns
ns
ns
0.000
ns
0.000
ns
ns
ns
0.001
ns
ns
ns
ns
0.000
ns
0.000
0.000
0.000
ns
ns
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.000
ns
0.001
0.001
ns
ns
0.000
ns
ns
ns
0.001
ns
ns
ns
ns
0.000
0.001
ns
ns
0.000
ns
ns
0.000
0.001
0.000
0.001
0.000
ns
ns
0.000
ns
0.000
ns
ns
0.000
ns
ns
0.001
ns
ns
1.19E-02
ns
ns
ns
ns
ns
ns
ns
ns
2.73E-02
2.94E-02
1.06E-08
1.57E-02
ns
ns
ns
1.34E-04
ns
5.52E-02
6.67E-01
ns
ns
ns
7.65E-01
4.35E-03
4.46E-01
ns
5.17E-14
ns
ns
ns
5.15E-01
ns
ns
9.24E-01
ns
4.11E-01
ns
9.85E-01
ns
ns
2.18E-01
3.20E-07
ns
1.31E-08
ns
ns
3.26E-07
7.88E-01
1.50E-01
ns
4.89E-05
ns
ns
6.11E-03
3.95E-06
ns
ns
ns
ns
1.50E-03
1.52E-02
ns
2.43E-04
ns
ns
1.23E-02
1.32E-08
6.96E-03
4.88E-01
ns
4.88E-03
1.62E-03
ns
ns
ns
ns
1.01E-02
6.37E-02
1.98E-08
ns
ns
ns
7.24E-19
ns
9.73E-01
ns
ns
ns
8.43E-05
ns
ns
ns
ns
1.62E-01
ns
2.73E-10
2.92E-15
1.49E-03
ns
ns
ns
ns
ns
ns
ns
ns
ns
ns
ns
3.27E-04
ns
1.73E-06
3.65E-01
ns
ns
2.08E-30
ns
ns
ns
8.01E-01
ns
ns
ns
ns
1.07E-06
1.31E-01
ns
ns
5.06E-01
ns
ns
7.10E-01
2.89E-03
1.73E-01
3.54E-03
3.15E-01
ns
ns
1.05E-01
ns
1.28E-02
ns
ns
2.01E-02
ns
ns
1.37E-02
ns
ns
-+
-+
--+
-+
-0+
+++
-+
-+
++
-+
-+?
-+
-+
-+
-+-+
+---+
+?
-+
-+
-?
+-+
+-?
-++?
-+?
+--?
--+
++++
+?
+?
+-+
+++
-?
-+
--+
-?
-+
--+
-?
----?
+?
++
++
--+
++
++
-+
-++
-+
-+
+?
+-0--?
-?
+++
-?
++
-+
++
-?
--+
++
-++
-+?
++
-+
--?
-?
-++
--+--?
-+
+++
+0+
-?
++
+++
-+
+++
++
+-+
-+
-?
-+
++
+-?
-?
+++
++
++
++
++?
-?
+?
-?
-?
+++
++
-+
+-+
++
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
134
362
362
362
134
362
362
134
362
134
362
362
134
362
362
362
362
362
134
134
362
362
362
362
134
362
362
362
134
362
362
362
134
362
362
362
134
134
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
134
134
362
362
134
362
362
362
134
362
362
362
362
362
362
134
362
362
362
134
134
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
362
134
134
362
362
362
362
362
362
134
134
134
134
134
362
362
362
362
362
362
362
-0.889
-0.836
-3.800
-0.773
0.476
-2.105
1.244
0.073
2.120
0.206
0.025
1.952
-0.138
-2.847
0.364
1.078
-0.077
-0.266
-3.846
-0.482
-0.673
-0.164
-0.930
-1.593
-0.080
0.262
-0.175
0.069
-2.330
0.118
-0.795
-0.355
-1.112
-1.184
-0.450
0.034
-0.942
0.010
-1.645
-1.391
-1.514
-2.639
-1.286
-0.465
-0.820
0.148
0.429
0.287
-1.807
-0.721
-0.288
1.318
-1.472
-0.670
-2.341
-0.728
-1.276
1.723
-1.761
-0.443
-0.889
-2.093
-3.177
-1.773
-1.518
0.145
1.531
1.251
-1.135
-0.173
0.993
1.620
-0.018
-2.143
0.219
1.156
1.051
0.317
-0.121
-1.154
-0.254
-0.820
-2.380
-4.115
-0.783
2.303
-1.691
1.593
2.263
0.079
-2.055
-1.714
-0.531
1.232
-2.589
2.324
-2.551
0.082
0.668
0.541
-0.888
-2.847
-1.148
-2.337
1.122
-2.659
-2.427
-0.250
-2.423
-3.274
-0.843
-0.881
2.018
-0.430
1.991
-2.958
0.401
-1.509
0.597
-0.184
-2.314
2.394
1.558
-1.657
-0.996
-0.420
-1.958
0.310
1.409
-1.625
-2.437
-1.071
-1.123
1.283
1.108
1.747
1.446
-0.950
0.008
-1.440
0.135
-1.495
-1.827
-1.620
0.014
1.622
0.117
-1.450
-0.433
0.532
3.74E-01
4.03E-01
1.45E-04
4.39E-01
6.34E-01
3.53E-02
2.14E-01
9.42E-01
3.40E-02
8.37E-01
9.80E-01
5.09E-02
8.90E-01
4.41E-03
7.16E-01
2.81E-01
9.38E-01
7.91E-01
1.20E-04
6.30E-01
5.01E-01
8.70E-01
3.52E-01
1.11E-01
9.36E-01
7.93E-01
8.61E-01
9.45E-01
1.98E-02
9.06E-01
4.26E-01
7.23E-01
2.66E-01
2.36E-01
6.53E-01
9.73E-01
3.46E-01
9.92E-01
1.00E-01
1.64E-01
1.30E-01
8.31E-03
1.98E-01
6.42E-01
4.12E-01
8.82E-01
6.68E-01
7.74E-01
7.07E-02
4.71E-01
7.73E-01
1.88E-01
1.41E-01
5.03E-01
1.92E-02
4.67E-01
2.02E-01
8.49E-02
7.82E-02
6.58E-01
3.74E-01
3.63E-02
1.49E-03
7.63E-02
1.29E-01
8.85E-01
1.26E-01
2.11E-01
2.57E-01
8.63E-01
3.21E-01
1.05E-01
9.86E-01
3.21E-02
8.27E-01
2.48E-01
2.93E-01
7.51E-01
9.03E-01
2.49E-01
8.00E-01
4.12E-01
1.73E-02
3.88E-05
4.34E-01
2.13E-02
9.09E-02
1.11E-01
2.37E-02
9.37E-01
3.99E-02
8.66E-02
5.96E-01
2.18E-01
9.64E-03
2.01E-02
1.07E-02
9.35E-01
5.04E-01
5.89E-01
3.75E-01
4.42E-03
2.51E-01
1.95E-02
2.62E-01
7.85E-03
1.52E-02
8.03E-01
1.54E-02
1.06E-03
3.99E-01
3.78E-01
4.36E-02
6.67E-01
4.64E-02
3.10E-03
6.89E-01
1.31E-01
5.51E-01
8.54E-01
2.06E-02
1.67E-02
1.19E-01
9.76E-02
3.19E-01
6.74E-01
5.02E-02
7.57E-01
1.59E-01
1.04E-01
1.48E-02
2.84E-01
2.62E-01
2.00E-01
2.68E-01
8.07E-02
1.48E-01
3.42E-01
9.94E-01
1.50E-01
8.93E-01
1.35E-01
6.77E-02
1.05E-01
9.89E-01
1.05E-01
9.07E-01
1.47E-01
6.65E-01
5.95E-01
26689
24154
52027
56843
40494
2502
50284
19192
45769
547
52193
1867
57199
7022
63977
60152
46995
42735
5699
9908
36913
27994
32613
4260
23536
34131
4838
27716
39025
15176
3844
22388
29161
15356
42204
60002
40354
14758
6105
68202
61881
32261
42751
23823
5820
11748
45292
28832
18950
61938
45816
63322
21755
32219
7240
40607
30048
61343
63873
37473
11441
18316
37659
39500
39818
39614
29970
62996
2033
52007
17530
11949
51294
14290
42278
55456
54540
27419
59778
2937
22151
2105
66623
3999
34136
5582
63841
64988
32326
24559
9123
7519
4856
22527
49276
39036
49624
37223
7563
53548
15057
26502
6209
15637
55459
148
47838
63902
15776
45903
12041
57181
35124
39997
37102
42597
10464
55257
12066
45497
58376
17138
59398
9320
6155
7351
32058
22361
55865
55643
49202
19917
31818
27234
53742
67015
37701
43841
56390
57060
56603
60097
15896
55973
1685
45378
14263
36162
65486
30709
1048
1049
1050
1051
1052
1053
1054
1055
1056
1057
1058
1059
1060
1061
1062
1063
1064
1065
1066
1067
1068
1069
1070
1071
1072
1073
1074
1075
1076
1077
1078
1079
1080
1081
1082
1083
1084
1085
1086
1087
1088
1089
1090
1091
1092
1093
1094
1095
1096
1097
1098
1099
1100
1101
1102
1103
1104
1105
1106
1107
1108
1109
1110
1111
1112
1113
1114
1115
1116
1117
1118
1119
1120
1121
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131
1132
1133
1134
1135
1136
1137
1138
1139
1140
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150
1151
1152
1153
1154
1155
1156
1157
1158
1159
1160
1161
1162
1163
1164
1165
1166
1167
1168
1169
1170
1171
1172
1173
1174
1175
1176
1177
1178
1179
1180
1181
1182
1183
1184
1185
1186
1187
1188
1189
1190
1191
1192
1193
1194
1195
1196
1197
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
8555
25946
375748
388335
51596
8685
22839
10813
55122
10528
140691
23404
11214
1436
6935
10745
10068
11119
931
10199
65083
253018
26234
645683
9537
135
29
55211
126299
6430
10673
2650
374946
83732
23500
91603
604
80024
8087
10939
51154
27334
23240
1509
11278
10541
5368
10555
84549
55617
6158
29968
3600
54915
79003
23460
80303
8522
53917
5594
5023
79031
9926
53343
55245
9466
4637
55003
6993
3636
7867
9775
2254
54841
516
54065
199746
483
55132
8562
64965
280636
1571
26034
9437
730092
1633
6426
23483
3336
4666
51523
2887
51645
9662
51227
3240
23398
54888
51573
22916
65095
84101
51199
7728
127703
6737
83743
338799
57215
113251
6235
10312
55775
7407
54205
80173
22986
3187
6139
9531
375387
6478
79137
57222
9868
37
9927
23384
79056
3313
84067
10379
51614
78987
9238
10801
123169
2519
11112
51001
10170
119504
6876
10598
10908
7593
10166
10437
2876
CDC14B
ZNF385A
ERCC6L2
TMEM220
CUTA
MARCO
DLGAP4
UTP14A
AKIRIN2
NOP56
TRIM69
EXOSC2
AKAP13
CSF1R
ZEB1
PHTF1
IL18BP
BTN3A1
MS4A1
MPHOSPH10
NOL6
HCG27
FBXL5
RPL13AP3
TP53I11
ADORA2A
ABR
DPPA4
ZNF428
SRSF5
TNFSF13B
GCNT1
DRAXIN
RIOK1
DAAM2
ZNF830
BCL6
SLC24A6
FXR1
AFG3L2
MRTO4
P2RY10
KIAA0922
CTSD
KLF12
ANP32B
PNOC
AGPAT2
MAK16
TASP1
RPL28
PSAT1
IL15
YTHDF1
MIS12
ABCA6
EFHD1
GAS7
RAB24
MAPK1
P2RX1
PDCL3
LPGAT1
NUDT9
UQCC
IL27RA
MYL6
PAK1IP1
DYNLT1
INPPL1
MAPKAPK3
EIF4A3
FGF9
BIVM
ATP5G1
FAM165B
U2AF1L4
ATP1B3
LARP1B
DENR
MRPS9
C11orf31
CYP2E1
IPCEF1
NCR1
RRN3P1
DCK
SRSF1
TGDS
HSPE1
NACA
CXXC5
GRB10
PPIL1
CEP135
PIGP
HP
PPWD1
NSUN2
GDE1
NCBP2
KRI1
USP44
NIN
ZNF175
C1orf216
TRIM21
GRWD1
LOC338799
THAP11
LARP4
RPS29
TCIRG1
TDP1
VARS
CYCS
IFT74
SORCS3
HNRNPH1
RPL17
BAG3
LRRC33
SIAH2
FAM134A
ERGIC1
TOMM70A
ACADVL
MFN2
SPECC1L
PRRG4
HSPA9
FAM160A2
IRF9
ERGIC3
CRELD1
TBRG4
SEPT9
LEO1
FUCA2
HIBADH
MTERFD1
DHRS9
ANAPC16
TAGLN
AHSA1
PNPLA6
MZF1
SLC25A15
IFI30
GPX1
++-++++++++
---------------+
++++++
++++++
---?-++++++
-----+
++++++
-----++++++
++-+++
--+?-+-++-+
++-+++
++++++
---------------+
++++-+
++++++
-----++++++
-----++-+++
---+----+-+----++++++
++++++
++++++
---?--+++++
--+--+++-++
------------------------------++++++
---------------++++++
---------------+
-----++++++
----------++++++
-----++++++
++++++
++++++
++++++
-----+-++-+
---------------+++++-----++++++
++-+++
++++++
-----+
+------------+-----------++-+++
---------------------------+?-+-++++
--------?--------+-----------------+
++++-+
-------+-----?-++++++
--+-------+++++--------------+--+-----+-++-+++
++++++
-----+
------------+-----+-+++?++
----------+
-----+
--+--+-++++
---------------++-+++
++++++
++-+++
++++++
-----++-+++
+++-++
-----++++-+
-----++-+++
++++-+
----------+
-----+
----------++++++
--------?-++++++
--+--++-+++
-----++-+++
----------++++++
++-+++
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6.733
7.488
-6.397
-6.815
-6.272
6.646
5.520
-7.186
6.750
-7.224
5.446
-6.670
5.579
5.655
-5.338
5.742
5.679
5.908
-5.332
-6.808
-6.472
5.261
6.442
-6.491
7.006
-6.457
6.194
-6.247
-5.179
-5.630
7.497
5.891
6.706
-6.360
5.906
-5.745
4.869
-5.095
-5.219
-6.278
-7.425
-6.256
-6.413
7.381
-7.001
-6.874
-5.353
6.696
-5.218
-6.618
-4.976
-4.958
5.778
-6.387
-6.327
6.198
-6.571
6.571
7.163
5.838
5.368
-5.310
6.323
-6.409
-5.525
-6.224
5.760
-6.519
6.751
6.100
5.932
-5.613
-6.027
-6.538
-5.398
-7.284
-6.460
6.156
-6.239
-6.491
-5.285
-5.571
-6.539
-5.131
5.905
-6.623
-6.870
-5.905
-5.357
-6.097
-5.916
-5.174
5.324
-5.476
-5.269
-5.686
6.771
-5.701
-6.703
4.980
-6.157
-5.809
-5.034
-4.738
-5.981
5.182
6.079
-6.137
-4.897
-6.650
-5.077
-6.508
5.912
-6.697
-4.803
-5.150
-6.891
5.018
-5.609
-6.654
-6.927
5.041
5.335
5.059
5.856
-6.965
5.156
5.311
-5.661
5.202
-6.544
6.114
6.867
-5.082
-5.999
-5.345
-6.010
-6.126
6.107
-6.267
-5.874
6.234
-6.078
5.830
-6.122
6.690
-4.856
-5.483
5.701
4.951
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.67E-11
7.01E-14
1.59E-10
9.42E-12
3.57E-10
3.02E-11
3.39E-08
6.66E-13
1.48E-11
5.04E-13
5.15E-08
2.56E-11
2.43E-08
1.55E-08
9.42E-08
9.35E-09
1.36E-08
3.46E-09
9.69E-08
9.88E-12
9.68E-11
1.43E-07
1.18E-10
8.50E-11
2.46E-12
1.07E-10
5.86E-10
4.18E-10
2.24E-07
1.81E-08
6.51E-14
3.84E-09
2.00E-11
2.01E-10
3.51E-09
9.22E-09
1.12E-06
3.49E-07
1.80E-07
3.42E-10
1.13E-13
3.96E-10
1.43E-10
1.58E-13
2.54E-12
6.23E-12
8.65E-08
2.15E-11
1.81E-07
3.64E-11
6.48E-07
7.12E-07
7.56E-09
1.69E-10
2.51E-10
5.73E-10
4.99E-11
4.98E-11
7.89E-13
5.30E-09
7.96E-08
1.10E-07
2.56E-10
1.47E-10
3.30E-08
4.86E-10
8.40E-09
7.07E-11
1.47E-11
1.06E-09
2.98E-09
1.99E-08
1.67E-09
6.23E-11
6.75E-08
3.24E-13
1.05E-10
7.45E-10
4.41E-10
8.51E-11
1.26E-07
2.53E-08
6.20E-11
2.88E-07
3.54E-09
3.51E-11
6.41E-12
3.52E-09
8.48E-08
1.08E-09
3.30E-09
2.29E-07
1.02E-07
4.35E-08
1.37E-07
1.30E-08
1.28E-11
1.19E-08
2.04E-11
6.35E-07
7.39E-10
6.29E-09
4.80E-07
2.16E-06
2.21E-09
2.20E-07
1.21E-09
8.39E-10
9.75E-07
2.93E-11
3.84E-07
7.60E-11
3.38E-09
2.13E-11
1.57E-06
2.61E-07
5.56E-12
5.23E-07
2.03E-08
2.85E-11
4.31E-12
4.62E-07
9.56E-08
4.23E-07
4.73E-09
3.29E-12
2.52E-07
1.09E-07
1.51E-08
1.97E-07
6.00E-11
9.74E-10
6.55E-12
3.73E-07
1.98E-09
9.07E-08
1.86E-09
8.98E-10
1.01E-09
3.69E-10
4.25E-09
4.54E-10
1.22E-09
5.53E-09
9.22E-10
2.22E-11
1.20E-06
4.19E-08
1.19E-08
7.39E-07
++-+++++
+-++++++
--+-+--+---++?-------+++++-++
++++++++
-+----+-+++++-+
------+++-+--++
-------++++++++
++++++++
?--+???+-+-++++
++-+++++
-++-++++
------+-+----------+-++++++++
+++-++++
---+---+++-++++
---+---++-+++++
?-+-???------+-----+-+++++++-++++-++
?++++??+
----+--+-++++++
--+----+++--+++
-----------------------------+-+--------+-++++++++
---------------------+
++++++++
----+-------?------+-+------+++++-++
--------------?++-++?+
---?-??+-+-++++
+++-+++++++++-+
++++++++
-----+-+-+-++-+
-+---------+-----+---+++++-++
-------++++++++
+++--+++
++++++++
----------+--+---------+-+-----+-+------+--++++-++
--+-----------------------??------?----+--?-+?+??+
--------------+
--------------------------------++-+
++++++++
-----------------+---+?+---++
--------------++++++0+
--------------+---?-+----------++--++++++++
++++++++
---+--------+------------+---------++++++++
----+------------------++-??+++---?+
------+-+-----+--+-+--+++++++
++++++++
++++++++
+-++++-+
-------++-+-+++
++++-+-+
-----+--+++++++
-------+++-++-+
+++-++++
--------------+
-----+----+-+-?
-------+++++-++
---------------+++++++
---+++--+++++++
---+----+-++-++
--------------+
++++++++
++++++++
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5242
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5242
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
7782
8009
8009
8009
8009
8009
5590
5966
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
6552
8009
5004
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
7497
8009
8009
8009
8009
8009
7888
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
4829
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5.14
4.42
-5.45
-4.96
-5.56
5.19
6.25
-4.75
5.07
-4.62
6.31
-5.13
6.17
6.09
-6.48
6.00
6.06
5.83
-6.37
-4.96
-5.28
6.43
5.30
-5.25
4.76
-5.28
5.52
-5.42
-6.48
-6.04
4.26
5.78
4.85
-5.37
5.76
-5.91
6.74
-6.52
-6.40
-5.39
-4.29
-5.40
-5.24
4.32
-4.68
-4.79
-6.23
4.94
-6.34
-5.00
-6.57
-6.58
5.80
-5.22
-5.28
5.33
-4.92
5.03
4.46
5.72
6.16
-6.21
5.24
-5.15
-5.99
-5.32
5.76
-5.03
4.81
5.43
5.58
-5.87
-5.47
-4.98
-6.07
-4.27
-5.05
5.34
-5.25
-5.01
-6.15
-5.90
-4.87
-6.27
5.55
-4.86
-4.71
-5.53
-6.05
-5.34
-5.50
-6.20
6.05
-5.91
-6.10
-5.71
4.63
-5.68
-4.71
6.34
-5.22
-5.55
-6.28
-6.56
-5.37
6.12
5.27
-5.21
-6.39
-4.72
-6.22
-4.85
5.43
-4.65
-6.45
-6.11
-4.30
6.28
-5.64
-4.65
-4.39
6.18
5.90
6.16
5.40
-4.34
6.06
5.91
-5.57
6.00
-4.71
5.12
4.40
-6.09
-5.22
-5.84
-5.16
-5.10
5.11
-4.96
-5.35
4.97
-5.11
5.34
-5.06
4.51
-6.26
-5.66
5.45
6.17
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2.76E-07
1.00E-05
5.00E-08
7.25E-07
2.77E-08
2.14E-07
4.09E-10
2.00E-06
3.96E-07
3.92E-06
2.83E-10
2.83E-07
6.78E-10
1.13E-09
8.99E-11
2.02E-09
1.41E-09
5.66E-09
1.94E-10
7.09E-07
1.30E-07
1.29E-10
1.15E-07
1.50E-07
1.91E-06
1.33E-07
3.37E-08
6.04E-08
9.13E-11
1.55E-09
2.07E-05
7.30E-09
1.24E-06
7.73E-08
8.46E-09
3.41E-09
1.55E-11
7.09E-11
1.59E-10
7.22E-08
1.76E-05
6.53E-08
1.57E-07
1.56E-05
2.87E-06
1.70E-06
4.58E-10
7.80E-07
2.26E-10
5.85E-07
5.15E-11
4.60E-11
6.53E-09
1.81E-07
1.33E-07
9.67E-08
8.77E-07
5.03E-07
8.14E-06
1.08E-08
7.16E-10
5.23E-10
1.64E-07
2.66E-07
2.15E-09
1.04E-07
8.45E-09
4.80E-07
1.50E-06
5.81E-08
2.43E-08
4.40E-09
4.49E-08
6.24E-07
1.30E-09
1.95E-05
4.48E-07
9.57E-08
1.50E-07
5.40E-07
7.75E-10
3.66E-09
1.12E-06
3.69E-10
2.80E-08
1.19E-06
2.54E-06
3.12E-08
1.46E-09
9.17E-08
3.87E-08
5.63E-10
1.41E-09
3.52E-09
1.07E-09
1.10E-08
3.74E-06
1.35E-08
2.50E-06
2.27E-10
1.80E-07
2.85E-08
3.30E-10
5.48E-11
7.91E-08
9.20E-10
1.38E-07
1.89E-07
1.68E-10
2.38E-06
5.12E-10
1.23E-06
5.65E-08
3.32E-06
1.14E-10
9.97E-10
1.71E-05
3.40E-10
1.66E-08
3.34E-06
1.14E-05
6.50E-10
3.70E-09
7.40E-10
6.77E-08
1.42E-05
1.39E-09
3.46E-09
2.51E-08
1.95E-09
2.45E-06
3.03E-07
1.08E-05
1.11E-09
1.81E-07
5.18E-09
2.53E-07
3.46E-07
3.20E-07
7.25E-07
8.60E-08
6.56E-07
3.23E-07
9.24E-08
4.26E-07
6.36E-06
3.83E-10
1.48E-08
4.95E-08
7.05E-10
15266
15266
15266
13809
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
11618
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12499
15266
15266
15266
15266
12620
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15039
15266
15266
15266
15266
15266
12847
13223
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13582
13809
14385
12261
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
14385
14754
15266
15266
15266
15266
15266
15145
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
13582
13809
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12086
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
8.364
8.362
-8.359
-8.353
-8.348
8.339
8.333
-8.331
8.327
-8.324
8.324
-8.318
8.316
8.311
-8.309
8.302
8.3
8.294
-8.288
-8.286
-8.286
8.284
8.281
-8.28
8.28
-8.272
8.27
-8.269
-8.264
-8.255
8.253
8.251
8.246
-8.244
8.243
-8.242
8.241
-8.234
-8.231
-8.23
-8.229
-8.227
-8.22
8.218
-8.217
-8.206
-8.205
8.195
-8.192
-8.191
-8.187
-8.187
8.187
-8.183
-8.182
8.176
-8.171
8.171
8.17
8.166
8.165
-8.16
8.152
-8.146
-8.145
-8.144
8.143
-8.141
8.139
8.135
8.131
-8.12
-8.118
-8.118
-8.116
-8.115
-8.11
8.109
-8.106
-8.105
-8.098
-8.098
-8.094
-8.092
8.09
-8.085
-8.085
-8.08
-8.074
-8.073
-8.06
-8.058
8.055
-8.053
-8.05
-8.05
8.046
-8.045
-8.032
8.027
-8.026
-8.025
-8.02
-8.016
-8.013
8.007
8.007
-8.005
-8.003
-8.002
-8.002
-8.001
7.987
-7.985
-7.981
-7.976
-7.971
7.963
-7.956
-7.955
-7.955
7.951
7.95
7.947
7.947
-7.946
7.942
7.941
-7.939
7.934
-7.925
7.925
7.922
-7.917
-7.916
-7.916
-7.916
-7.916
7.913
-7.909
-7.906
7.901
-7.891
7.888
-7.884
7.883
-7.883
-7.883
7.881
7.879
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
6.06E-17
6.17E-17
6.34E-17
6.64E-17
6.94E-17
7.51E-17
7.87E-17
8.01E-17
8.31E-17
8.50E-17
8.52E-17
8.97E-17
9.11E-17
9.52E-17
9.66E-17
1.02E-16
1.04E-16
1.10E-16
1.16E-16
1.17E-16
1.17E-16
1.19E-16
1.22E-16
1.23E-16
1.23E-16
1.32E-16
1.34E-16
1.36E-16
1.41E-16
1.51E-16
1.55E-16
1.57E-16
1.63E-16
1.67E-16
1.68E-16
1.70E-16
1.70E-16
1.81E-16
1.85E-16
1.88E-16
1.89E-16
1.92E-16
2.04E-16
2.08E-16
2.09E-16
2.28E-16
2.30E-16
2.51E-16
2.58E-16
2.59E-16
2.67E-16
2.68E-16
2.69E-16
2.77E-16
2.78E-16
2.94E-16
3.06E-16
3.07E-16
3.08E-16
3.18E-16
3.22E-16
3.35E-16
3.57E-16
3.77E-16
3.80E-16
3.82E-16
3.86E-16
3.92E-16
3.97E-16
4.12E-16
4.27E-16
4.64E-16
4.75E-16
4.76E-16
4.81E-16
4.85E-16
5.08E-16
5.12E-16
5.23E-16
5.25E-16
5.58E-16
5.60E-16
5.76E-16
5.87E-16
5.95E-16
6.22E-16
6.24E-16
6.46E-16
6.78E-16
6.84E-16
7.62E-16
7.73E-16
7.92E-16
8.09E-16
8.26E-16
8.31E-16
8.57E-16
8.65E-16
9.61E-16
9.97E-16
1.01E-15
1.01E-15
1.06E-15
1.09E-15
1.12E-15
1.17E-15
1.18E-15
1.19E-15
1.21E-15
1.22E-15
1.22E-15
1.24E-15
1.38E-15
1.40E-15
1.46E-15
1.51E-15
1.58E-15
1.68E-15
1.78E-15
1.79E-15
1.80E-15
1.86E-15
1.87E-15
1.91E-15
1.91E-15
1.93E-15
1.99E-15
2.00E-15
2.04E-15
2.12E-15
2.28E-15
2.29E-15
2.34E-15
2.43E-15
2.46E-15
2.46E-15
2.46E-15
2.46E-15
2.51E-15
2.59E-15
2.66E-15
2.77E-15
2.99E-15
3.06E-15
3.17E-15
3.20E-15
3.21E-15
3.21E-15
3.26E-15
3.31E-15
?
?
?
?
+
?
+
?
?
+
+
?
+
?
?
?
+
+
?
+
?
?
?
+
+
+
+
?
?
?
+
?
?
?
?
+
?
+
?
+
+
?
?
?
+
?
+
?
+
?
+
?
+
+
?
?
+
+
+
+
?
?
+
+
?
?
?
?
?
?
+
+
?
+
?
+
+
+
?
?
+
?
+
+
?
+
+
+
+
+
+
?
+
+
?
+
+
+
?
?
?
+
394
0
394
0
394
0
394
0
394
394
0
394
0
394
0
394
394
394
0
394
0
0
394
394
0
394
394
0
394
394
0
0
0
394
394
394
394
394
394
394
394
0
0
0
394
394
0
0
0
0
394
394
0
394
394
0
394
394
394
0
0
394
0
394
394
0
394
394
394
0
394
394
394
394
394
394
394
0
394
394
394
0
394
394
0
0
394
394
394
394
394
394
394
394
394
0
0
394
394
394
394
0
0
0
0
0
0
394
394
394
0
394
0
394
394
394
394
0
0
394
394
0
394
394
394
394
394
394
394
0
394
394
394
394
394
394
394
394
0
394
394
0
394
394
394
394
0
0
0
394
-0.005
ns
-0.003
ns
-0.006
ns
-0.009
ns
-0.011
0.005
ns
0.011
ns
-0.011
ns
-0.003
0.008
0.010
ns
0.010
ns
ns
-0.004
0.000
ns
0.009
0.004
ns
-0.010
0.009
ns
ns
ns
-0.001
-0.001
-0.001
0.013
0.014
-0.001
0.003
0.001
ns
ns
ns
0.001
-0.006
ns
ns
ns
ns
0.005
-0.003
ns
0.014
-0.006
ns
-0.005
0.007
0.014
ns
ns
-0.008
ns
-0.004
0.007
ns
-0.014
0.006
-0.013
ns
0.000
-0.003
0.000
-0.001
-0.002
-0.007
-0.001
ns
-0.009
-0.006
0.003
ns
0.023
0.005
ns
ns
-0.007
0.006
-0.001
-0.010
-0.004
0.002
0.017
-0.008
0.012
ns
ns
0.004
0.011
-0.005
-0.007
ns
ns
ns
ns
ns
ns
0.009
0.004
-0.007
ns
0.003
ns
0.009
0.004
-0.014
0.009
ns
ns
-0.003
0.009
ns
-0.003
-0.003
-0.004
-0.002
0.000
0.005
0.012
ns
-0.003
0.004
0.002
0.000
0.007
0.008
0.002
-0.004
ns
0.007
0.000
ns
0.006
0.009
-0.003
0.005
ns
ns
ns
0.001
0.003
ns
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
ns
0.003
ns
0.004
0.003
0.003
ns
0.003
ns
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
ns
ns
0.003
0.004
0.004
0.003
0.003
0.003
0.003
0.003
ns
ns
ns
0.004
0.004
ns
ns
ns
ns
0.003
0.003
ns
0.003
0.003
ns
0.004
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
0.003
0.004
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
ns
ns
ns
ns
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
0.004
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.004
ns
0.003
0.003
0.003
0.003
ns
ns
ns
0.003
1.21E-01
ns
3.25E-01
ns
6.30E-02
ns
8.95E-03
ns
8.64E-04
1.66E-01
ns
7.02E-04
ns
7.97E-04
ns
4.62E-01
1.98E-02
1.88E-03
ns
6.27E-04
ns
ns
2.23E-01
9.69E-01
ns
1.17E-03
1.86E-01
ns
8.23E-04
1.09E-03
ns
ns
ns
8.56E-01
7.04E-01
7.62E-01
1.34E-05
2.80E-06
7.42E-01
3.63E-01
6.56E-01
ns
ns
ns
7.92E-01
1.03E-01
ns
ns
ns
ns
1.08E-01
2.62E-01
ns
8.19E-07
4.14E-02
ns
1.36E-01
3.63E-02
8.04E-06
ns
ns
5.31E-03
ns
2.72E-01
2.91E-02
ns
9.26E-06
8.54E-02
5.95E-05
ns
9.29E-01
3.78E-01
9.97E-01
8.39E-01
4.58E-01
3.69E-02
7.01E-01
ns
2.26E-03
5.52E-02
2.60E-01
ns
9.57E-12
1.76E-01
ns
ns
1.80E-02
6.78E-02
7.92E-01
3.68E-03
2.14E-01
6.18E-01
1.31E-07
1.43E-02
4.40E-05
ns
ns
2.62E-01
1.63E-03
1.59E-01
1.59E-02
ns
ns
ns
ns
ns
ns
8.92E-03
1.33E-01
3.55E-02
ns
3.35E-01
ns
7.34E-03
2.01E-01
4.91E-07
8.49E-04
ns
ns
4.18E-01
5.95E-03
ns
3.34E-01
3.21E-01
2.13E-01
5.57E-01
8.69E-01
1.21E-01
2.30E-05
ns
4.33E-01
2.29E-01
5.31E-01
9.25E-01
2.43E-02
1.58E-02
4.98E-01
2.48E-01
ns
1.68E-02
9.37E-01
ns
6.52E-02
1.34E-02
3.22E-01
1.08E-01
ns
ns
ns
6.68E-01
+
?
?
?
?
+
+
?
?
?
?
?
+
?
?
+
+
?
?
?
+
?
?
?
+
+
+
+
?
?
?
+
?
?
?
?
+
+
?
+
+
?
+
+
+
?
?
+
?
+
?
+
+
?
+
?
+
+
+
+
+
?
?
+
+
+
+
+
?
?
+
+
+
?
?
?
?
?
?
+
?
?
+
?
+
+
?
?
?
+
?
+
+
+
?
+
+
+
+
+
+
+
?
+
+
+
+
?
?
-
394
0
394
0
394
0
394
0
394
394
394
394
0
394
0
394
0
0
0
394
0
0
394
394
0
0
394
0
394
394
0
0
0
394
394
394
394
394
394
394
394
0
0
0
394
394
0
0
0
0
394
394
0
394
394
0
394
394
394
0
0
394
0
394
394
0
394
394
394
0
394
394
394
394
394
394
394
0
394
394
394
394
394
394
0
0
394
394
394
394
394
394
394
394
394
0
0
394
394
394
394
0
0
0
0
0
0
394
0
394
0
394
0
394
394
394
0
0
0
394
394
0
394
394
394
394
394
394
394
0
394
394
394
394
394
394
394
394
394
394
394
0
394
394
394
394
0
394
0
394
0.003
ns
-0.006
ns
-0.003
ns
-0.009
ns
-0.017
0.012
-0.004
0.009
ns
-0.021
ns
-0.004
ns
ns
ns
0.009
ns
ns
0.000
0.007
ns
ns
-0.007
ns
-0.002
0.010
ns
ns
ns
-0.004
0.012
-0.006
0.007
0.011
0.008
-0.001
0.000
ns
ns
ns
-0.003
0.011
ns
ns
ns
ns
0.007
0.008
ns
0.009
0.005
ns
0.012
0.011
0.006
ns
ns
0.004
ns
-0.002
0.003
ns
-0.009
0.003
0.002
ns
0.006
-0.003
-0.001
-0.004
0.000
-0.010
-0.004
ns
0.012
0.003
0.002
-0.013
0.000
0.003
ns
ns
-0.017
0.007
0.009
-0.005
-0.002
0.009
0.002
-0.010
0.010
ns
ns
0.005
0.006
0.003
-0.005
ns
ns
ns
ns
ns
ns
0.012
ns
-0.015
ns
0.015
ns
0.009
0.019
-0.018
ns
ns
ns
-0.008
0.007
ns
-0.018
-0.005
-0.012
-0.005
0.010
0.006
0.017
ns
-0.005
-0.009
0.013
0.007
0.008
0.014
0.014
-0.007
0.001
0.014
-0.002
ns
0.008
0.008
0.003
0.012
ns
-0.007
ns
-0.002
0.003
ns
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
0.003
ns
ns
ns
0.003
ns
ns
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
ns
ns
ns
0.003
0.004
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
ns
0.004
0.003
ns
ns
ns
ns
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.004
0.004
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.004
0.003
0.003
ns
ns
ns
ns
ns
ns
0.003
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.004
0.003
0.004
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
0.003
3.29E-01
ns
6.83E-02
ns
3.09E-01
ns
5.31E-03
ns
2.55E-07
6.19E-04
2.22E-01
4.86E-03
ns
2.29E-11
ns
2.61E-01
ns
ns
ns
8.37E-04
ns
ns
9.63E-01
4.53E-02
ns
ns
2.90E-02
ns
4.78E-01
3.97E-04
ns
ns
ns
2.12E-01
1.11E-03
6.84E-02
2.73E-02
1.06E-03
1.66E-02
6.65E-01
8.81E-01
ns
ns
ns
3.28E-01
9.00E-04
ns
ns
ns
ns
2.05E-02
1.45E-02
ns
1.43E-03
1.10E-01
ns
2.29E-04
5.50E-04
3.46E-02
ns
ns
1.73E-01
ns
4.93E-01
2.86E-01
ns
3.91E-03
2.91E-01
6.22E-01
ns
6.08E-02
4.33E-01
8.11E-01
1.10E-01
9.14E-01
1.22E-03
1.71E-01
ns
8.34E-04
3.52E-01
5.21E-01
4.31E-05
8.93E-01
3.36E-01
ns
ns
5.51E-08
2.71E-02
1.16E-02
1.30E-01
5.04E-01
8.03E-03
5.26E-01
1.91E-03
1.37E-03
ns
ns
1.31E-01
9.73E-02
3.14E-01
9.30E-02
ns
ns
ns
ns
ns
ns
6.86E-05
ns
3.49E-06
ns
5.34E-06
ns
4.14E-03
8.30E-10
2.51E-09
ns
ns
ns
1.73E-02
3.00E-02
ns
1.49E-07
9.37E-02
4.52E-06
1.35E-01
3.04E-04
5.82E-02
1.50E-09
ns
1.45E-01
1.63E-03
2.43E-05
3.72E-02
6.72E-03
1.82E-05
2.60E-05
3.32E-02
7.38E-01
5.20E-06
5.25E-01
ns
1.79E-02
7.36E-03
2.92E-01
6.24E-05
ns
4.67E-02
ns
6.36E-01
++
-+
-?+?+
++
?
++
+++
-++
++
-++
++
-?+
-?-+
-?
-+
+++
?-+
+?
?++
?+
--+
?
++
?--+?
?-+??++
-+--++
?+?-+
++
++
+-+
++
?+
+--++?++
++
+-+
-+
--?
+?+
-+---+
-?
??
-+?
----+
-+
++
-+?+
++++
-+?
+++++
-+
+--+
-+++
-++
++
-++
-?
?+-+
?+
++
?-?+
--?
?+
+++
+-+++?
+++
+-?+
+?
?+
+++
-+
--+
-+
515
515
515
213
515
213
515
0
515
515
515
515
515
515
515
515
515
515
213
515
213
515
515
0
515
515
515
213
515
302
213
515
213
515
515
0
515
213
515
515
515
0
213
515
515
213
213
515
515
515
515
515
515
213
515
213
515
515
515
515
515
515
213
515
515
515
515
515
213
515
515
515
515
515
515
302
515
213
515
515
515
515
515
302
213
0
515
302
515
515
515
515
515
515
515
515
213
515
515
515
515
302
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
515
302
213
515
515
213
515
213
515
213
515
302
213
515
515
515
515
515
515
302
515
515
515
515
213
302
213
515
515
515
515
515
515
0.916
-0.008
-1.136
-1.522
0.342
1.640
3.797
ns
2.673
-0.951
5.895
-2.076
0.797
1.508
-0.762
1.919
2.710
-0.078
3.175
-1.341
-0.650
1.200
-0.458
ns
1.900
-0.141
1.945
-3.649
-0.233
0.908
-0.270
1.722
2.157
-1.563
-0.131
ns
2.372
-3.482
-0.939
-2.572
-0.534
ns
-1.576
-0.705
-0.264
-1.047
-0.295
2.052
-1.458
-0.417
-1.733
-1.414
3.921
-0.703
-0.663
-0.462
0.571
1.483
0.268
1.398
-0.551
0.624
1.188
-0.238
-1.995
-2.391
0.594
-1.283
-0.650
1.432
1.169
0.908
1.245
-0.030
-2.612
-1.722
0.221
1.193
-0.851
-0.056
-0.482
-2.060
0.874
-1.878
-0.102
ns
-1.352
2.790
-1.257
-0.845
-0.775
-1.451
-0.588
1.341
-1.550
-0.919
1.011
0.061
0.144
0.457
-0.428
0.651
-1.132
-0.600
-0.237
2.163
-0.532
-0.530
-1.710
-0.487
-2.719
-1.747
2.990
-1.643
1.432
0.837
-1.595
2.903
-0.999
-0.388
1.844
-0.313
1.960
0.729
-1.094
-0.531
0.133
-0.493
-0.964
2.115
1.270
1.242
-0.040
-1.723
-0.988
-0.203
0.613
-0.883
2.577
-2.063
-0.369
0.740
0.015
2.569
0.268
1.603
0.126
-2.270
1.459
0.784
3.60E-01
9.94E-01
2.56E-01
1.28E-01
7.33E-01
1.01E-01
1.46E-04
ns
7.52E-03
3.42E-01
3.74E-09
3.79E-02
4.25E-01
1.32E-01
4.46E-01
5.50E-02
6.73E-03
9.38E-01
1.50E-03
1.80E-01
5.16E-01
2.30E-01
6.47E-01
ns
5.75E-02
8.88E-01
5.17E-02
2.63E-04
8.16E-01
3.64E-01
7.87E-01
8.50E-02
3.10E-02
1.18E-01
8.96E-01
ns
1.77E-02
4.97E-04
3.48E-01
1.01E-02
5.93E-01
ns
1.15E-01
4.81E-01
7.92E-01
2.95E-01
7.68E-01
4.02E-02
1.45E-01
6.77E-01
8.30E-02
1.58E-01
8.80E-05
4.82E-01
5.08E-01
6.44E-01
5.68E-01
1.38E-01
7.89E-01
1.62E-01
5.81E-01
5.33E-01
2.35E-01
8.12E-01
4.60E-02
1.68E-02
5.53E-01
1.99E-01
5.16E-01
1.52E-01
2.42E-01
3.64E-01
2.13E-01
9.76E-01
9.00E-03
8.51E-02
8.25E-01
2.33E-01
3.95E-01
9.55E-01
6.30E-01
3.94E-02
3.82E-01
6.04E-02
9.19E-01
ns
1.76E-01
5.27E-03
2.09E-01
3.98E-01
4.39E-01
1.47E-01
5.57E-01
1.80E-01
1.21E-01
3.58E-01
3.12E-01
9.52E-01
8.85E-01
6.48E-01
6.69E-01
5.15E-01
2.58E-01
5.48E-01
8.13E-01
3.05E-02
5.95E-01
5.96E-01
8.73E-02
6.27E-01
6.55E-03
8.06E-02
2.79E-03
1.00E-01
1.52E-01
4.03E-01
1.11E-01
3.70E-03
3.18E-01
6.98E-01
6.52E-02
7.54E-01
5.00E-02
4.66E-01
2.74E-01
5.95E-01
8.94E-01
6.22E-01
3.35E-01
3.44E-02
2.04E-01
2.14E-01
9.68E-01
8.49E-02
3.23E-01
8.39E-01
5.40E-01
3.77E-01
9.97E-03
3.92E-02
7.12E-01
4.59E-01
9.88E-01
1.02E-02
7.89E-01
1.09E-01
9.00E-01
2.32E-02
1.45E-01
4.33E-01
+
?
?
+
?
+
+
+
+
+
+
?
?
?
+
+
+
?
+
?
+
?
?
+
?
?
?
+
?
?
+
+
?
?
+
+
+
+
?
+
?
+
+
+
?
?
?
+
+
+
+
+
+
+
+
+
+
+
?
+
+
?
+
?
?
+
?
+
+
+
+
+
?
?
+
+
+
-
299
299
299
0
299
0
299
0
299
299
299
299
299
299
299
299
299
299
0
299
0
299
299
0
299
299
299
0
299
299
0
299
0
299
299
0
299
0
299
299
299
0
0
299
299
0
0
299
299
299
299
299
299
0
299
0
299
299
299
299
299
299
0
299
299
299
299
299
0
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
0
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
0
299
0
299
0
299
299
0
299
299
299
299
299
299
299
299
299
299
299
0
299
0
299
299
299
299
299
299
0.002
-0.001
-0.015
ns
-0.007
ns
0.006
ns
0.026
-0.007
0.012
-0.001
0.006
0.035
-0.003
0.008
0.012
-0.002
ns
-0.002
ns
-0.006
-0.003
ns
0.003
0.012
0.024
ns
-0.005
0.001
ns
0.006
ns
-0.006
-0.002
ns
0.033
ns
-0.013
-0.008
-0.001
ns
ns
0.011
-0.004
ns
ns
0.008
-0.017
-0.002
-0.012
-0.002
0.021
ns
-0.010
ns
-0.006
0.027
0.014
0.011
0.016
-0.003
ns
0.000
-0.017
-0.009
0.020
-0.005
ns
0.016
0.009
-0.003
-0.006
-0.004
-0.005
-0.003
0.003
ns
-0.005
-0.004
-0.007
-0.002
-0.004
-0.015
ns
ns
-0.020
-0.006
-0.011
-0.003
-0.014
-0.010
-0.002
-0.001
-0.008
-0.001
0.002
-0.010
-0.005
0.000
-0.014
-0.004
0.002
0.001
0.000
0.009
0.007
-0.001
-0.009
-0.017
-0.010
-0.012
0.030
-0.009
0.002
0.002
-0.012
0.001
-0.018
ns
0.010
0.007
ns
0.003
ns
-0.012
ns
0.012
-0.011
ns
0.004
0.006
0.008
-0.021
-0.013
-0.015
0.000
-0.003
0.007
-0.009
-0.005
ns
-0.024
ns
0.005
0.021
-0.013
-0.009
0.022
-0.003
0.002
0.002
0.006
ns
0.005
ns
0.004
ns
0.007
0.008
0.003
0.003
0.004
0.011
0.002
0.003
0.005
0.007
ns
0.004
ns
0.003
0.008
ns
0.002
0.007
0.005
ns
0.006
0.005
ns
0.002
ns
0.005
0.002
ns
0.009
ns
0.005
0.004
0.003
ns
ns
0.004
0.007
ns
ns
0.003
0.007
0.003
0.003
0.002
0.004
ns
0.005
ns
0.002
0.007
0.007
0.004
0.005
0.004
ns
0.003
0.005
0.003
0.004
0.003
ns
0.008
0.006
0.005
0.004
0.004
0.005
0.002
0.006
ns
0.005
0.005
0.005
0.002
0.003
0.004
ns
ns
0.006
0.005
0.004
0.004
0.006
0.004
0.002
0.002
0.005
0.001
0.002
0.007
0.005
0.004
0.005
0.004
0.002
0.003
0.002
0.003
0.003
0.004
0.003
0.006
0.005
0.006
0.010
0.004
0.005
0.004
0.004
0.002
0.012
ns
0.006
0.003
ns
0.003
ns
0.005
ns
0.005
0.005
ns
0.006
0.005
0.006
0.004
0.005
0.006
0.004
0.003
0.002
0.005
0.004
ns
0.008
ns
0.004
0.010
0.006
0.003
0.008
0.007
3.56E-01
8.12E-01
8.01E-03
ns
1.48E-01
ns
1.65E-01
ns
1.08E-04
4.35E-01
7.89E-05
6.77E-01
1.90E-01
1.33E-03
1.61E-01
2.13E-03
8.88E-03
7.88E-01
ns
6.96E-01
ns
5.19E-02
7.03E-01
ns
1.69E-01
7.61E-02
3.41E-07
ns
3.51E-01
8.92E-01
ns
7.14E-04
ns
2.17E-01
1.88E-01
ns
7.18E-04
ns
8.89E-03
8.20E-02
6.35E-01
ns
ns
1.16E-02
5.75E-01
ns
ns
1.69E-02
1.18E-02
4.62E-01
1.06E-04
3.55E-01
2.03E-07
ns
5.45E-02
ns
4.31E-03
1.14E-04
4.37E-02
2.67E-03
1.73E-03
4.46E-01
ns
9.24E-01
1.99E-03
9.26E-03
6.06E-06
8.04E-02
ns
3.59E-02
1.09E-01
4.80E-01
1.27E-01
2.97E-01
2.98E-01
2.45E-01
6.38E-01
ns
2.94E-01
3.38E-01
1.49E-01
3.16E-01
1.79E-01
1.28E-03
ns
ns
1.65E-03
2.12E-01
6.03E-03
4.49E-01
1.84E-02
1.41E-02
4.25E-01
6.38E-01
1.20E-01
6.96E-01
3.93E-01
1.77E-01
3.84E-01
9.06E-01
3.79E-03
3.13E-01
3.39E-01
8.48E-01
9.00E-01
3.28E-03
3.97E-02
7.83E-01
6.02E-04
2.97E-03
3.69E-02
4.57E-02
1.83E-03
4.00E-02
6.35E-01
7.14E-01
5.59E-03
7.42E-01
1.22E-01
ns
9.29E-02
4.89E-02
ns
3.27E-01
ns
2.70E-02
ns
1.96E-02
1.83E-02
ns
4.52E-01
2.40E-01
1.74E-01
2.48E-06
5.86E-03
1.21E-02
9.68E-01
3.54E-01
5.45E-03
7.65E-02
1.71E-01
ns
2.00E-03
ns
1.78E-01
3.04E-02
2.68E-02
6.46E-04
7.88E-03
6.56E-01
+++
-?
-+
-++
++
?+
-+
-+
+?
--+
++
+?
-+
++
-+
+-+
-+
++
-?++
+++
+?
+?+
-+
-+
+?
-+?++
++
-+
-+
-?-+
++
--+
++-----+
-+
--+
+?
-+
++
-++
--+
++
--+
---+
++
+-++
--?
++
-+
----?
+?
?+
+?
?
-?+
---+++
+-+
--+
-+
-+
--?+
+-+
-+
+?
--++
+--++
-+
++
--+
++
?-++
++
++
+++
-++
-+
?+
-+
-+
++
-+
-+-?
-+
--+
--+
?
++
-+
++
++
++
++
+-
567
567
213
567
567
567
567
354
567
567
213
567
567
567
213
567
567
567
567
567
567
567
567
354
567
567
567
213
567
354
567
567
213
567
567
354
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
567
0
567
567
567
567
567
213
213
354
213
0
567
354
567
567
567
567
567
567
567
567
567
567
567
567
567
354
567
567
567
213
567
567
567
567
567
567
567
567
567
567
567
567
354
567
567
567
567
567
567
567
567
567
354
567
567
567
567
567
567
567
0
567
567
567
567
567
0
567
567
567
567
567
567
567
0.674
3.540
-1.323
-0.037
-1.082
1.790
3.833
0.757
2.380
-1.124
0.410
-2.587
1.172
3.064
0.754
-0.273
1.340
1.637
-0.772
-0.439
1.650
3.442
-2.555
-2.158
1.982
0.778
2.799
0.617
0.355
2.186
0.137
0.664
2.209
-1.995
0.412
-0.676
3.777
2.325
0.358
0.080
-2.404
-1.635
-1.148
1.914
-0.776
-1.140
-0.408
0.307
-4.477
-1.930
-0.970
-0.362
0.499
0.169
-3.264
0.466
1.465
1.555
1.030
-1.909
0.738
-1.623
0.320
1.154
-3.702
-0.125
-1.581
-3.921
-0.331
3.214
0.143
-2.904
1.044
-1.136
-2.871
ns
1.150
1.511
-2.722
-2.269
-1.183
-1.224
0.970
0.403
0.447
ns
-3.557
0.906
-2.222
-2.828
-2.327
-0.531
2.566
-1.925
0.548
-1.127
0.341
0.690
0.573
-1.850
-1.336
1.267
1.704
0.664
-0.600
0.800
-1.011
-0.677
1.882
-1.827
-4.183
-4.157
3.435
-1.358
1.645
-2.177
-0.125
1.621
-0.008
-3.244
1.078
1.582
1.807
-0.291
2.625
-1.770
2.195
1.836
2.536
0.641
-0.555
1.549
2.126
-3.170
-0.557
-1.599
ns
-0.451
-2.580
-1.208
-3.572
-1.116
ns
3.340
-0.725
4.454
4.310
2.222
0.873
-1.500
5.00E-01
4.00E-04
1.86E-01
9.71E-01
2.79E-01
7.35E-02
1.27E-04
4.49E-01
1.73E-02
2.61E-01
6.82E-01
9.68E-03
2.41E-01
2.19E-03
4.51E-01
7.85E-01
1.80E-01
1.02E-01
4.40E-01
6.61E-01
9.90E-02
5.78E-04
1.06E-02
3.09E-02
4.75E-02
4.37E-01
5.13E-03
5.37E-01
7.23E-01
2.88E-02
8.91E-01
5.07E-01
2.72E-02
4.60E-02
6.81E-01
4.99E-01
1.59E-04
2.01E-02
7.20E-01
9.36E-01
1.62E-02
1.02E-01
2.51E-01
5.56E-02
4.38E-01
2.54E-01
6.83E-01
7.59E-01
7.56E-06
5.36E-02
3.32E-01
7.18E-01
6.18E-01
8.66E-01
1.10E-03
6.41E-01
1.43E-01
1.20E-01
3.03E-01
5.63E-02
4.61E-01
1.05E-01
7.49E-01
2.49E-01
2.14E-04
9.01E-01
1.14E-01
8.84E-05
7.41E-01
1.31E-03
8.86E-01
3.69E-03
2.97E-01
2.56E-01
4.09E-03
ns
2.50E-01
1.31E-01
6.49E-03
2.32E-02
2.37E-01
2.21E-01
3.32E-01
6.87E-01
6.55E-01
ns
3.75E-04
3.65E-01
2.63E-02
4.68E-03
2.00E-02
5.95E-01
1.03E-02
5.43E-02
5.83E-01
2.60E-01
7.33E-01
4.90E-01
5.66E-01
6.43E-02
1.82E-01
2.05E-01
8.84E-02
5.06E-01
5.49E-01
4.24E-01
3.12E-01
4.98E-01
5.99E-02
6.77E-02
2.88E-05
3.23E-05
5.93E-04
1.75E-01
1.00E-01
2.95E-02
9.01E-01
1.05E-01
9.94E-01
1.18E-03
2.81E-01
1.14E-01
7.08E-02
7.71E-01
8.66E-03
7.67E-02
2.82E-02
6.64E-02
1.12E-02
5.21E-01
5.79E-01
1.21E-01
3.35E-02
1.52E-03
5.77E-01
1.10E-01
ns
6.52E-01
9.87E-03
2.27E-01
3.55E-04
2.64E-01
ns
8.37E-04
4.68E-01
8.44E-06
1.63E-05
2.63E-02
3.83E-01
1.34E-01
?
+
+
+
+
+
+
+
+
?
?
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
+
+
+
+
+
?
+
+
?
+
+
+
+
+
+
?
+
?
+
+
?
+
+
+
+
?
+
+
?
?
+
+
+
+
+
+
+
+
+
+
+
+
?
?
+
+
+
+
+
+
+
?
+
+
+
+
?
?
+
+
+
+
+
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
0
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
0
869
869
0
869
869
869
869
869
869
869
0
869
0
869
869
869
0
869
869
869
869
869
869
0
869
869
869
869
0
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
0
0
869
869
869
869
869
869
ns
0.005
0.000
-0.002
-0.002
0.000
0.000
0.002
0.000
0.001
-0.002
0.004
-0.004
-0.001
-0.002
-0.001
0.003
-0.003
-0.003
0.001
0.004
0.000
-0.002
ns
ns
-0.002
0.002
0.000
0.001
-0.002
0.002
0.001
0.000
0.000
0.001
ns
-0.003
0.000
-0.003
0.001
0.005
0.000
-0.002
0.001
0.001
0.004
-0.001
0.001
0.002
0.001
-0.001
0.006
-0.001
0.001
0.002
0.004
-0.001
0.001
-0.002
0.000
-0.002
ns
-0.002
0.000
0.002
0.000
0.003
0.002
-0.001
0.000
0.001
0.000
ns
0.001
0.002
ns
0.003
0.003
0.000
0.003
0.002
0.001
-0.001
ns
0.000
ns
0.002
0.003
0.000
ns
0.003
0.001
0.000
0.004
0.001
0.000
ns
0.001
0.000
0.002
-0.002
ns
ns
0.002
0.000
0.000
0.003
0.003
0.004
0.002
0.004
-0.002
0.001
0.004
0.004
0.003
0.000
ns
ns
-0.001
-0.001
-0.001
0.000
0.002
0.000
-0.001
-0.002
0.002
-0.001
0.000
0.001
0.000
0.000
0.002
-0.001
0.000
ns
0.001
-0.001
0.002
0.002
0.005
ns
ns
0.003
0.001
0.000
0.002
0.000
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
ns
0.001
0.001
0.001
0.001
0.001
0.002
0.003
0.001
0.001
0.002
ns
0.001
0.000
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.002
0.001
0.002
0.001
0.001
0.002
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
ns
0.001
0.001
0.001
ns
0.001
0.001
0.000
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
ns
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
ns
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.000
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
ns
ns
0.001
0.001
0.000
0.001
0.001
0.001
ns
2.68E-04
7.25E-01
1.71E-03
6.73E-02
7.23E-01
8.95E-01
5.04E-02
6.48E-01
3.79E-01
4.26E-01
4.85E-04
7.03E-04
3.02E-01
6.08E-02
4.66E-01
3.13E-03
3.77E-03
9.09E-03
6.19E-01
1.53E-04
9.33E-01
6.88E-02
ns
ns
8.61E-02
5.78E-03
5.35E-01
8.50E-02
5.95E-03
2.93E-01
5.90E-01
8.14E-01
8.20E-01
7.97E-01
ns
5.33E-02
3.11E-01
4.91E-03
3.19E-01
5.15E-04
7.25E-01
3.73E-02
1.92E-01
6.67E-01
2.57E-04
4.31E-01
3.39E-01
1.17E-01
5.37E-01
1.67E-01
4.70E-03
5.42E-01
4.80E-01
1.50E-01
2.65E-02
7.00E-02
7.43E-01
3.41E-02
6.74E-01
2.74E-01
ns
1.36E-01
8.70E-01
3.19E-02
9.35E-01
3.79E-02
1.68E-01
4.30E-01
5.00E-01
6.23E-01
6.68E-01
ns
6.59E-01
4.08E-04
ns
1.07E-03
1.05E-02
7.40E-01
5.76E-03
3.46E-02
1.13E-01
2.33E-01
ns
4.39E-01
ns
2.27E-01
1.28E-03
6.15E-01
ns
1.17E-03
1.57E-01
6.92E-01
2.36E-03
2.80E-01
9.09E-01
ns
3.49E-01
8.33E-01
5.22E-02
3.04E-02
ns
ns
3.97E-02
9.95E-01
9.62E-01
7.56E-03
1.79E-02
6.21E-06
8.65E-03
1.68E-03
3.90E-02
4.39E-02
8.52E-07
1.83E-04
6.44E-04
9.74E-01
ns
ns
4.85E-01
5.63E-01
5.65E-01
9.72E-01
3.98E-04
9.57E-01
3.99E-01
1.32E-02
4.12E-02
2.90E-01
9.75E-01
1.25E-01
3.02E-01
7.54E-01
3.86E-02
1.55E-02
7.96E-01
ns
2.83E-01
2.82E-01
4.13E-02
1.78E-01
2.84E-04
ns
ns
1.75E-02
4.91E-02
9.73E-01
7.22E-02
7.99E-01
3.67E-01
?
+
?
?
?
?
?
+
?
+
+
+
?
+
?
?
?
?
?
?
+
+
?
?
?
?
?
?
?
?
+
?
?
+
+
?
?
?
?
?
+
+
?
?
?
?
+
?
?
?
?
?
?
+
+
+
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
?
+
?
?
?
?
+
?
?
?
?
?
+
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
+
?
0
1244
1244
0
0
0
0
0
1244
1244
0
1244
1244
1244
0
1244
0
0
0
1244
1244
0
0
0
1244
1244
1244
0
1244
0
0
0
0
0
0
0
1244
1244
0
1244
0
1244
1244
1244
0
0
0
0
1244
0
1244
1244
1244
1244
1244
1244
0
0
0
0
1244
0
0
0
0
1244
0
0
1244
1244
1244
0
1244
1244
0
1244
0
0
1244
0
1244
0
0
1244
0
0
0
0
0
1244
0
1244
0
1244
0
0
0
1244
1244
1244
0
0
0
0
1244
1244
0
1244
0
1244
0
0
1244
0
0
1244
0
0
1244
1244
0
1244
0
0
0
0
0
1244
0
0
1244
0
0
0
0
0
0
1244
0
1244
0
0
0
0
1244
0
0
1244
1244
0
ns
0.001
-0.001
ns
ns
ns
ns
ns
0.002
-0.001
ns
0.001
0.000
0.002
ns
0.000
ns
ns
ns
-0.001
0.000
ns
ns
ns
0.000
0.000
0.002
ns
0.000
ns
ns
ns
ns
ns
ns
ns
0.004
-0.001
ns
0.000
ns
0.000
-0.002
0.002
ns
ns
ns
ns
-0.001
ns
-0.001
0.000
0.002
0.000
-0.001
0.000
ns
ns
ns
ns
0.002
ns
ns
ns
ns
-0.001
ns
ns
0.001
0.002
0.001
ns
0.000
-0.001
ns
-0.001
ns
ns
0.000
ns
-0.001
ns
ns
-0.004
ns
ns
ns
ns
ns
-0.003
ns
-0.003
ns
0.000
ns
ns
ns
-0.001
-0.001
0.001
ns
ns
ns
ns
-0.001
0.003
ns
-0.001
ns
0.000
ns
ns
0.003
ns
ns
0.000
ns
ns
-0.001
-0.002
ns
0.001
ns
ns
ns
ns
ns
0.001
ns
ns
-0.002
ns
ns
ns
ns
ns
ns
0.000
ns
0.000
ns
ns
ns
ns
0.000
ns
ns
0.000
0.001
ns
ns
0.000
0.000
ns
ns
ns
ns
ns
0.000
0.000
ns
0.001
0.000
0.001
ns
0.000
ns
ns
ns
0.000
0.000
ns
ns
ns
0.000
0.000
0.000
ns
0.000
ns
ns
ns
ns
ns
ns
ns
0.001
0.000
ns
0.000
ns
0.000
0.000
0.001
ns
ns
ns
ns
0.000
ns
0.000
0.000
0.000
0.000
0.000
0.000
ns
ns
ns
ns
0.001
ns
ns
ns
ns
0.000
ns
ns
0.000
0.000
0.001
ns
0.000
0.000
ns
0.000
ns
ns
0.000
ns
0.000
ns
ns
0.000
ns
ns
ns
ns
ns
0.001
ns
0.000
ns
0.000
ns
ns
ns
0.000
0.000
0.000
ns
ns
ns
ns
0.000
0.000
ns
0.000
ns
0.000
ns
ns
0.001
ns
ns
0.000
ns
ns
0.001
0.001
ns
0.000
ns
ns
ns
ns
ns
0.000
ns
ns
0.000
ns
ns
ns
ns
ns
ns
0.000
ns
0.000
ns
ns
ns
ns
0.000
ns
ns
0.000
0.001
ns
ns
8.09E-02
1.50E-04
ns
ns
ns
ns
ns
8.44E-05
1.02E-01
ns
8.99E-02
1.78E-01
3.97E-02
ns
4.87E-02
ns
ns
ns
1.34E-03
2.86E-02
ns
ns
ns
2.68E-03
4.40E-01
1.03E-09
ns
4.85E-01
ns
ns
ns
ns
ns
ns
ns
1.27E-05
2.25E-04
ns
1.78E-01
ns
7.77E-01
5.97E-08
4.20E-04
ns
ns
ns
ns
1.55E-04
ns
1.04E-04
9.50E-01
4.47E-08
1.78E-01
1.53E-01
5.03E-01
ns
ns
ns
ns
1.12E-03
ns
ns
ns
ns
1.11E-02
ns
ns
4.54E-02
1.88E-03
7.19E-02
ns
1.31E-01
2.64E-05
ns
9.97E-03
ns
ns
2.69E-01
ns
6.52E-02
ns
ns
4.24E-25
ns
ns
ns
ns
ns
2.83E-04
ns
3.33E-11
ns
1.58E-01
ns
ns
ns
2.09E-02
2.39E-05
1.76E-03
ns
ns
ns
ns
1.18E-03
5.10E-18
ns
5.10E-02
ns
9.16E-01
ns
ns
1.23E-06
ns
ns
1.13E-01
ns
ns
3.03E-01
2.69E-02
ns
7.50E-02
ns
ns
ns
ns
ns
8.53E-04
ns
ns
1.21E-04
ns
ns
ns
ns
ns
ns
3.05E-02
ns
1.73E-02
ns
ns
ns
ns
6.10E-01
ns
ns
7.55E-02
1.39E-01
ns
++
++
-+
-?
-+
+++
-++
+-+
-+
+++
-+
+?
++
+--+
--?
--?
++
-+
++
-?
-+
-+-+
+?
--?
-?
++
--+
++
++
-+
-+-+
-+
+++
-+
-+
++
-?
++
+-+
-?
-?
++++
++
-?
++
-+
+-++
-++++
+-?
-+
-+
-?
-+
++
++
-+
-+
--?
-?
+?
-?
-+
---+
-+
++
+?
++
--+
+?
--++
--?
-?
-+?
++
++-?
-+
-++
+++
++
-+
-+?
-?
-+
-+
++
++
++
++
-+
+++
-+
+-+
++++
+--?
++
++-+
++
-+
+++--?
+++
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
134
362
362
362
134
362
362
362
362
134
362
134
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
134
134
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
134
362
362
362
362
362
362
134
134
134
134
362
362
362
362
362
362
134
362
362
362
134
362
362
362
362
134
134
362
134
362
362
362
134
362
362
362
362
362
362
362
362
134
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
2.442
0.545
-0.958
-0.925
-0.167
-0.648
1.696
-1.041
0.492
-1.475
-0.405
-0.738
-1.159
0.202
0.788
0.593
2.604
-0.334
-2.940
-0.711
-1.818
-1.158
-1.416
-2.364
1.133
1.338
0.369
-1.183
1.130
-1.798
-0.526
-0.486
0.251
-1.368
-0.708
-1.185
0.891
-3.139
0.168
1.164
0.727
0.265
-3.441
-0.605
1.104
-1.174
-1.059
0.786
-0.275
0.413
0.778
-1.227
0.503
-1.018
0.560
-1.483
-1.382
-0.784
-0.640
0.503
1.035
-1.849
1.558
-0.541
-1.976
-0.954
1.327
-1.183
-0.480
-0.699
0.315
0.086
-1.812
-0.556
0.222
-1.338
-0.346
0.348
1.060
-0.541
-0.375
-2.700
-1.805
-2.370
0.487
-1.983
-1.307
-2.414
-1.107
-0.714
-0.368
0.671
0.026
0.390
-1.706
-0.268
0.035
-1.454
-1.744
1.548
-0.617
-1.279
-1.344
-2.005
0.362
1.426
-0.628
-0.653
-1.842
1.346
-1.811
1.607
-0.398
1.356
1.147
-0.070
-1.428
0.146
-0.974
-0.391
0.712
1.078
1.027
1.971
1.008
-0.286
-0.819
0.553
-0.566
-1.033
-0.169
-0.759
-1.160
1.134
-0.768
-1.727
-1.317
0.549
-0.415
-0.459
-0.861
0.667
-0.244
-0.431
-0.289
0.048
-2.887
-0.747
-0.428
0.204
1.46E-02
5.86E-01
3.38E-01
3.55E-01
8.67E-01
5.17E-01
8.99E-02
2.98E-01
6.23E-01
1.40E-01
6.86E-01
4.61E-01
2.46E-01
8.40E-01
4.31E-01
5.53E-01
9.22E-03
7.38E-01
3.28E-03
4.77E-01
6.91E-02
2.47E-01
1.57E-01
1.81E-02
2.57E-01
1.81E-01
7.12E-01
2.37E-01
2.58E-01
7.22E-02
5.99E-01
6.27E-01
8.02E-01
1.71E-01
4.79E-01
2.36E-01
3.73E-01
1.70E-03
8.67E-01
2.44E-01
4.67E-01
7.91E-01
5.79E-04
5.45E-01
2.69E-01
2.40E-01
2.89E-01
4.32E-01
7.83E-01
6.79E-01
4.37E-01
2.20E-01
6.15E-01
3.09E-01
5.76E-01
1.38E-01
1.67E-01
4.33E-01
5.22E-01
6.15E-01
3.01E-01
6.44E-02
1.19E-01
5.89E-01
4.82E-02
3.40E-01
1.85E-01
2.37E-01
6.31E-01
4.84E-01
7.53E-01
9.31E-01
7.00E-02
5.78E-01
8.24E-01
1.81E-01
7.30E-01
7.28E-01
2.89E-01
5.89E-01
7.08E-01
6.94E-03
7.11E-02
1.78E-02
6.26E-01
4.74E-02
1.91E-01
1.58E-02
2.68E-01
4.75E-01
7.13E-01
5.02E-01
9.79E-01
6.96E-01
8.79E-02
7.89E-01
9.72E-01
1.46E-01
8.12E-02
1.22E-01
5.37E-01
2.01E-01
1.79E-01
4.49E-02
7.17E-01
1.54E-01
5.30E-01
5.14E-01
6.55E-02
1.78E-01
7.01E-02
1.08E-01
6.90E-01
1.75E-01
2.52E-01
9.44E-01
1.53E-01
8.84E-01
3.30E-01
6.96E-01
4.77E-01
2.81E-01
3.04E-01
4.88E-02
3.14E-01
7.75E-01
4.13E-01
5.80E-01
5.72E-01
3.02E-01
8.66E-01
4.48E-01
2.46E-01
2.57E-01
4.43E-01
8.41E-02
1.88E-01
5.83E-01
6.78E-01
6.46E-01
3.89E-01
5.05E-01
8.08E-01
6.66E-01
7.73E-01
9.61E-01
3.89E-03
4.55E-01
6.68E-01
8.39E-01
46377
34424
33847
51626
64058
68543
46157
37746
48338
28573
59992
44492
7512
58301
63464
52885
47600
51246
58285
50583
15044
29169
37361
20364
19561
33112
9938
13565
53537
49413
24489
67444
64203
417
8816
57230
52212
41919
63773
62484
54527
5784
58759
8340
37323
35593
49125
16615
6152
26282
45830
9338
4749
4669
2140
45273
26695
14935
47060
18988
52348
30134
1997
64942
34162
19141
44361
7145
64119
9448
29922
4618
43044
51593
40687
42868
66991
68466
37766
10583
58646
32957
64691
49293
39556
25994
10100
68410
46882
33005
64331
33453
44738
30234
7764
3836
55683
17314
47709
52901
18593
7020
10441
55324
53485
48699
60442
44851
38234
67743
15597
672
12904
31488
28276
15831
60659
27052
2840
2036
21156
12693
5634
41697
40486
35138
11186
16128
5748
34184
29540
39838
31346
10088
52856
53321
12039
1517
30463
62769
11427
14318
57820
17189
39244
19369
22467
24439
20265
60995
1198
1199
1200
1201
1202
1203
1204
1205
1206
1207
1208
1209
1210
1211
1212
1213
1214
1215
1216
1217
1218
1219
1220
1221
1222
1223
1224
1225
1226
1227
1228
1229
1230
1231
1232
1233
1234
1235
1236
1237
1238
1239
1240
1241
1242
1243
1244
1245
1246
1247
1248
1249
1250
1251
1252
1253
1254
1255
1256
1257
1258
1259
1260
1261
1262
1263
1264
1265
1266
1267
1268
1269
1270
1271
1272
1273
1274
1275
1276
1277
1278
1279
1280
1281
1282
1283
1284
1285
1286
1287
1288
1289
1290
1291
1292
1293
1294
1295
1296
1297
1298
1299
1300
1301
1302
1303
1304
1305
1306
1307
1308
1309
1310
1311
1312
1313
1314
1315
1316
1317
1318
1319
1320
1321
1322
1323
1324
1325
1326
1327
1328
1329
1330
1331
1332
1333
1334
1335
1336
1337
1338
1339
1340
1341
1342
1343
1344
1345
1346
1347
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
23
9185
81890
3075
8934
23409
8073
10399
25776
729230
2996
1503
10417
64328
79711
2647
9191
22859
10158
123
27101
6774
8464
3176
144402
23596
10404
51303
4548
170960
3659
339324
2717
9465
3608
7343
28987
10474
671
5698
57706
10198
8638
1075
55353
57724
4615
91272
23597
56894
5218
4222
57658
55843
5066
10432
3707
3921
2130
6198
56647
64216
8111
1665
114904
26003
131583
9047
8575
8720
401884
8607
10963
951
54107
84792
119559
79897
5567
10475
253558
103
4147
64219
116987
84896
284001
7920
5442
10915
9948
50512
84223
2185
84888
2793
3417
26094
79863
79868
4739
26973
10422
3276
10329
6135
10221
27173
7094
51545
9666
1207
81
6838
222487
55326
65082
660
84268
64097
5783
8985
27339
84650
6574
79600
6599
3437
7133
51569
22875
201456
408
54434
11340
29058
7675
114548
64855
84190
6157
10780
7327
55695
1528
9786
26040
8975
9760
10803
ABCF1
REPS2
QTRT1
CFH
RAB7L1
SIRT4
PTP4A2
GNB2L1
CBY1
CCR2
GYPE
CTPS1
SPON2
XPO4
IPO4
BLOC1S1
DEDD
LPHN1
PDZK1IP1
PLIN2
CACYBP
STAT3
SUPT3H
HNMT
CPNE8
OPN3
CPQ
FKBP11
MTR
ZNF721
IRF1
ZNF260
GLA
AKAP7
ILF2
UBTF
NOB1
TADA3
BPI
PSMB9
DENND1A
MPHOSPH9
OASL
CTSC
LAPTM4B
EPG5
MYD88
BOD1
ACOT9
AGPAT3
CDK14
MEOX1
CALCOCO1
ARHGAP15
PAM
RBM14
ITPKB
RPSA
EWSR1
RPS6KB1
BCCIP
TFB2M
GPR68
DHX15
C1QTNF6
GORASP2
FAM43A
SH2D2A
PRKRA
MBTPS1
MGC57346
RUVBL1
STIP1
CD37
POLE3
FAM220A
SFXN4
RPP21
PRKACB
TRIM38
LCLAT1
ADAR
MATN2
PJA1
AGAP1
ATAD1
CCDC57
ABHD16A
POLRMT
TCERG1
WDR1
PODXL2
IQCG
PTK2B
SPPL2A
GNGT2
IDH1
DCAF4
RBFA
ALG13
NEDD9
CHORDC1
UBAC1
PRMT1
TMEM5
RPL11
TRIB1
SLC39A1
TLN1
ZNF581
DZIP3
CLNS1A
ACTN4
SURF6
GPR97
AGPAT5
VPS33A
BMX
RPAIN
EPB41L4A
PTPN13
PLOD3
PRPF19
EBPL
SLC20A1
TCTN1
SMARCC1
IFIT3
TNFRSF1B
UFM1
ENPP4
FBXO15
ARRB1
SSH1
EXOSC8
TMEM230
ZNF121
NLRP3
FAM129B
METTL25
RPL27A
ZNF234
UBE2G2
NSUN5
CYB5A
KIAA0586
SETBP1
USP13
TOX
CCR9
-----++++++
-----++++++
++-+++
---?-++-+++
----------++++++
---+------++++++
---?------+
+++?++
++-+++
-----++-++++++++
----+++++++
-----+-++++
++++++
--+--++++-+
---------------++++++
-----++++++
----+---+-+
--------?-+++?++
++++++
+++?++
++++++
-----++++++
++++++
-----++++-+
++++-+
-----++++++
++++++
++++-+
++++++
++++-+
-----++-+++
-----------------------------------++-+++
--------------------+
++++++
--------?----------+-----------------------------------++-?++
+----++-+++
----------++++++
----------++++++
-+--------++++++
-----+
++++++
++++++
++++++
++-+++
++++-+
---------------+-++++
--+--++-+++
---------------+++?++
++++++
++-+++
--------+----+-++++++
-----++++++
-----++-+++
++++++
----+++++++
+----++-+++
----------++-+++
-+--------++++++
+++-++
---?-+-++++
-----++++++
++-+++
--------?---+--++++++
++++++
--++---------------------+
-----+----++-+++
-----++++++
------
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-5.912
5.194
-5.239
5.798
4.716
-6.671
4.722
-4.648
-5.747
5.725
-6.599
-5.991
5.672
-6.878
-5.808
6.276
6.172
-4.955
4.826
6.135
-5.576
5.544
-6.321
5.645
6.242
-4.721
4.689
-6.649
-6.564
-5.945
5.526
-6.781
6.180
-6.621
-4.949
-6.120
-5.235
6.497
5.845
6.715
6.731
-6.550
6.579
6.410
-5.954
4.992
6.274
-6.377
6.250
6.262
5.695
6.170
5.834
-5.916
4.787
-5.772
-5.388
-5.783
-6.519
-6.321
-5.791
-5.895
5.464
-6.207
-5.085
-5.817
-5.129
4.751
-5.884
-5.925
-5.590
-4.945
-5.584
-4.643
-5.380
-5.712
-6.013
-5.022
-6.083
4.659
-5.186
4.676
-5.955
-5.799
6.435
-5.665
-5.942
5.736
-5.441
-4.798
6.259
-5.732
5.169
5.277
6.216
4.619
6.177
-5.627
-6.122
-5.459
6.034
-6.170
5.693
-6.370
-5.458
-5.691
6.342
4.979
5.081
-4.738
-5.938
-6.121
5.324
-5.034
4.989
-5.664
5.139
5.813
-5.789
6.092
-5.747
5.035
-5.600
-4.684
4.946
-6.243
-5.743
4.960
5.399
-4.868
4.918
-5.134
4.960
5.905
-4.637
-5.079
-4.970
5.982
5.818
-4.902
-5.508
-6.006
-6.134
-4.856
-5.738
-5.400
6.169
-5.333
5.167
-5.972
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
3.39E-09
2.06E-07
1.61E-07
6.71E-09
2.40E-06
2.54E-11
2.33E-06
3.36E-06
9.09E-09
1.04E-08
4.15E-11
2.09E-09
1.42E-08
6.08E-12
6.33E-09
3.47E-10
6.75E-10
7.22E-07
1.40E-06
8.53E-10
2.46E-08
2.95E-08
2.60E-10
1.65E-08
4.33E-10
2.35E-06
2.74E-06
2.95E-11
5.22E-11
2.76E-09
3.27E-08
1.20E-11
6.41E-10
3.56E-11
7.44E-07
9.37E-10
1.65E-07
8.18E-11
5.08E-09
1.88E-11
1.68E-11
5.76E-11
4.74E-11
1.46E-10
2.62E-09
5.97E-07
3.53E-10
1.80E-10
4.11E-10
3.80E-10
1.23E-08
6.85E-10
5.41E-09
3.30E-09
1.69E-06
7.82E-09
7.11E-08
7.35E-09
7.09E-11
2.60E-10
6.99E-09
3.75E-09
4.65E-08
5.40E-10
3.68E-07
5.97E-09
2.91E-07
2.02E-06
4.01E-09
3.13E-09
2.28E-08
7.63E-07
2.36E-08
3.43E-06
7.47E-08
1.12E-08
1.82E-09
5.11E-07
1.18E-09
3.18E-06
2.15E-07
2.92E-06
2.60E-09
6.68E-09
1.23E-10
1.47E-08
2.82E-09
9.68E-09
5.29E-08
1.61E-06
3.88E-10
9.95E-09
2.36E-07
1.32E-07
5.10E-10
3.86E-06
6.54E-10
1.84E-08
9.23E-10
4.78E-08
1.60E-09
6.81E-10
1.25E-08
1.90E-10
4.81E-08
1.27E-08
2.27E-10
6.40E-07
3.75E-07
2.16E-06
2.88E-09
9.28E-10
1.02E-07
4.81E-07
6.06E-07
1.48E-08
2.77E-07
6.15E-09
7.08E-09
1.12E-09
9.08E-09
4.77E-07
2.14E-08
2.81E-06
7.58E-07
4.28E-10
9.31E-09
7.06E-07
6.70E-08
1.13E-06
8.76E-07
2.84E-07
7.05E-07
3.52E-09
3.54E-06
3.79E-07
6.69E-07
2.20E-09
5.97E-09
9.48E-07
3.62E-08
1.90E-09
8.55E-10
1.20E-06
9.58E-09
6.67E-08
6.87E-10
9.65E-08
2.38E-07
2.34E-09
-------++++++-+
------+?++++??+
++++++++
-----??++++++++
--------------+?++--++
---+-------++-+++-++-+
--------------++++++++
+-++++++
-----+-+++++-++
-++-++++
-+-----++++++++
++-+-??++++-+++
+++++-++
-+-----++++++-+
----+--+
--------------++++++++
-------++++++++
+-----------------------+----+++++++
++++++-+
++++++++
++++++++
-------++++++++
+++-++++
+------+
++----++
++++++++
-------+++++-++
++++++++
-++--+-+
++++-+?+
+++-++-+
-------+++++-++
-------+
-------+
?----??-----+-+
--+------+------+----++-+++++
----------+-+?-------+
---+---++-+++++
------------------++-+
--------+-+--+-----+-----------+---+
--+--+-------+-++-++--+++++++
-----+-++++++++
+---??----+---+
-+++++++
-+---------++-++++++++
-----+--------+++---++
---?-??++++-+++
+-++++++
++++++++
++++++++
-++++-++
-------+
---------------+--++?+
------++++++-++
----------+---+------++++++++
++++++++
++-+++++
---++----+?+-+-------++++++++
----+--++---+++
-+-----++++--++
-+++++++
-+------++++-++
-+-+?+?++-+-+++
---+---+
-------+++-++++
---++-------+-++++++++
+-++++++
-+-----+++-++-+
+-----?+++++-++
-+++++++
--------+-----+--?-??++++++++
++++--++
--+-+--+--------------------+
-----+-----+------+---+++++++
+--------+-+??+
+--????-
8009
8009
8009
5363
8009
6325
8009
8009
8009
7497
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
7661
8009
8009
8009
8009
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
7650
8009
8009
8009
8009
8009
8009
8009
8009
8009
6431
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
5845
-5.25
5.93
-5.88
5.32
6.36
-4.44
6.33
-6.40
-5.36
5.37
-4.52
-5.10
5.41
-4.35
-5.26
4.87
4.90
-6.06
6.17
4.92
-5.45
5.48
-4.65
5.37
4.80
-6.24
6.27
-4.40
-4.48
-5.06
5.46
-4.25
4.82
-4.39
-5.97
-4.85
-5.69
4.56
5.10
4.36
4.25
-4.42
4.39
4.55
-4.98
5.90
4.67
-4.56
4.67
4.65
5.19
4.67
5.06
-4.97
6.04
-5.10
-5.46
-5.03
-4.37
-4.54
-5.04
-4.94
5.34
-4.63
-5.73
-5.00
-5.65
6.00
-4.93
-4.91
-5.18
-5.78
-5.17
-6.06
-5.36
-5.03
-4.73
-5.66
-4.64
5.96
-5.49
5.97
-4.74
-4.89
4.28
-5.01
-4.75
4.94
-5.22
-5.82
4.43
-4.88
5.47
5.35
4.44
5.96
4.47
-4.99
-4.51
-5.13
4.50
-4.45
4.90
-4.26
-5.12
-4.90
4.33
5.55
5.45
-5.77
-4.61
-4.45
5.21
-5.48
5.52
-4.87
5.37
4.73
-4.74
4.45
-4.71
5.44
-4.89
-5.75
5.50
-4.26
-4.73
5.47
5.05
-5.54
5.50
-5.31
5.45
4.55
-5.76
-5.33
-5.47
4.45
4.60
-5.47
-4.89
-4.41
-4.29
-5.50
-4.66
-4.98
4.24
-5.03
5.19
-4.30
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.56E-07
3.10E-09
4.05E-09
1.06E-07
2.03E-10
9.18E-06
2.40E-10
1.52E-10
8.56E-08
8.08E-08
6.09E-06
3.38E-07
6.49E-08
1.37E-05
1.44E-07
1.13E-06
9.63E-07
1.39E-09
6.81E-10
8.52E-07
5.00E-08
4.28E-08
3.39E-06
7.79E-08
1.62E-06
4.37E-10
3.61E-10
1.07E-05
7.46E-06
4.16E-07
4.88E-08
2.17E-05
1.47E-06
1.15E-05
2.32E-09
1.22E-06
1.28E-08
5.15E-06
3.32E-07
1.33E-05
2.14E-05
9.78E-06
1.12E-05
5.34E-06
6.22E-07
3.65E-09
3.08E-06
5.03E-06
3.08E-06
3.26E-06
2.07E-07
3.06E-06
4.24E-07
6.57E-07
1.50E-09
3.37E-07
4.66E-08
4.82E-07
1.25E-05
5.62E-06
4.57E-07
7.96E-07
9.10E-08
3.65E-06
1.02E-08
5.87E-07
1.62E-08
1.93E-09
8.44E-07
8.91E-07
2.22E-07
7.44E-09
2.35E-07
1.33E-09
8.42E-08
4.94E-07
2.24E-06
1.56E-08
3.48E-06
2.49E-09
4.11E-08
2.37E-09
2.19E-06
1.02E-06
1.86E-05
5.32E-07
2.03E-06
7.93E-07
1.83E-07
5.75E-09
9.37E-06
1.06E-06
4.59E-08
8.62E-08
8.93E-06
2.52E-09
7.94E-06
6.16E-07
6.39E-06
2.94E-07
6.71E-06
8.69E-06
9.50E-07
2.07E-05
3.03E-07
9.75E-07
1.49E-05
2.86E-08
5.11E-08
7.80E-09
4.00E-06
8.61E-06
1.91E-07
4.28E-08
3.39E-08
1.10E-06
7.89E-08
2.27E-06
2.15E-06
8.67E-06
2.53E-06
5.47E-08
1.01E-06
8.90E-09
3.84E-08
2.03E-05
2.24E-06
4.48E-08
4.44E-07
2.96E-08
3.76E-08
1.13E-07
4.98E-08
5.36E-06
8.64E-09
9.86E-08
4.48E-08
8.59E-06
4.27E-06
4.55E-08
1.01E-06
1.02E-05
1.82E-05
3.79E-08
3.16E-06
6.30E-07
2.21E-05
4.91E-07
2.09E-07
1.75E-05
15266
15266
15266
12620
15266
12701
15266
15266
15266
14754
15266
15266
15266
14385
15266
14385
15266
15266
15266
15266
15266
15266
13582
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
14385
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13809
15266
15266
15266
15266
15266
12620
15266
15266
15266
15266
15266
15266
13809
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
14918
15266
15266
15266
15266
15266
15266
15266
15266
13223
15266
15266
15266
15266
15266
15266
15266
15266
13809
15266
15266
15266
15266
15266
14385
15266
15266
15266
14907
15266
15266
15266
15266
15266
15266
15266
15266
15266
13688
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
13809
15266
15266
15266
14385
13223
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
13582
13102
-7.875
7.873
-7.873
7.862
7.858
-7.857
7.843
-7.842
-7.841
7.839
-7.826
-7.825
7.825
-7.824
-7.814
7.81
7.804
-7.803
7.796
7.796
-7.793
7.791
-7.791
7.783
7.777
-7.775
7.775
-7.773
-7.771
-7.765
7.762
-7.751
7.749
-7.743
-7.739
-7.734
-7.73
7.727
7.727
7.72
7.719
-7.719
7.718
7.715
-7.715
7.715
7.705
-7.703
7.688
7.688
7.688
7.687
7.686
-7.681
7.679
-7.675
-7.673
-7.666
-7.659
-7.647
-7.646
-7.64
7.638
-7.633
-7.631
-7.629
-7.628
7.624
-7.624
-7.611
-7.606
-7.596
-7.594
-7.593
-7.59
-7.58
-7.572
-7.558
-7.555
7.55
-7.549
7.548
-7.547
-7.538
7.538
-7.538
-7.537
7.531
-7.529
-7.526
7.525
-7.524
7.523
7.515
7.503
7.502
7.494
-7.491
-7.49
-7.478
7.476
-7.476
7.475
-7.475
-7.473
-7.47
7.453
7.452
7.449
-7.448
-7.447
-7.443
7.442
-7.439
7.438
-7.435
7.432
7.432
-7.424
7.421
-7.41
7.409
-7.403
-7.395
7.392
-7.391
-7.386
7.382
7.38
-7.377
7.376
-7.375
7.369
7.367
-7.366
-7.358
-7.357
7.348
7.341
-7.34
-7.34
-7.337
-7.334
-7.332
-7.332
-7.331
7.326
-7.32
7.319
-7.313
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
3.41E-15
3.45E-15
3.46E-15
3.77E-15
3.91E-15
3.94E-15
4.39E-15
4.42E-15
4.47E-15
4.54E-15
5.04E-15
5.08E-15
5.09E-15
5.13E-15
5.53E-15
5.70E-15
6.01E-15
6.02E-15
6.39E-15
6.41E-15
6.54E-15
6.64E-15
6.67E-15
7.07E-15
7.42E-15
7.56E-15
7.57E-15
7.66E-15
7.78E-15
8.15E-15
8.37E-15
9.14E-15
9.28E-15
9.74E-15
9.99E-15
1.04E-14
1.08E-14
1.10E-14
1.10E-14
1.16E-14
1.17E-14
1.17E-14
1.19E-14
1.21E-14
1.21E-14
1.21E-14
1.31E-14
1.33E-14
1.49E-14
1.49E-14
1.49E-14
1.51E-14
1.52E-14
1.57E-14
1.61E-14
1.66E-14
1.69E-14
1.77E-14
1.88E-14
2.06E-14
2.07E-14
2.18E-14
2.21E-14
2.29E-14
2.33E-14
2.36E-14
2.39E-14
2.45E-14
2.46E-14
2.71E-14
2.84E-14
3.05E-14
3.11E-14
3.12E-14
3.20E-14
3.45E-14
3.67E-14
4.08E-14
4.19E-14
4.34E-14
4.38E-14
4.40E-14
4.47E-14
4.76E-14
4.77E-14
4.78E-14
4.79E-14
5.04E-14
5.09E-14
5.24E-14
5.28E-14
5.31E-14
5.35E-14
5.67E-14
6.25E-14
6.31E-14
6.68E-14
6.85E-14
6.89E-14
7.56E-14
7.68E-14
7.68E-14
7.70E-14
7.72E-14
7.85E-14
8.03E-14
9.11E-14
9.16E-14
9.40E-14
9.49E-14
9.57E-14
9.82E-14
9.90E-14
1.01E-13
1.02E-13
1.05E-13
1.07E-13
1.07E-13
1.14E-13
1.16E-13
1.26E-13
1.28E-13
1.33E-13
1.42E-13
1.44E-13
1.45E-13
1.52E-13
1.56E-13
1.59E-13
1.62E-13
1.64E-13
1.64E-13
1.72E-13
1.74E-13
1.76E-13
1.87E-13
1.88E-13
2.02E-13
2.12E-13
2.13E-13
2.14E-13
2.18E-13
2.24E-13
2.27E-13
2.27E-13
2.28E-13
2.37E-13
2.48E-13
2.49E-13
2.61E-13
+
?
+
?
+
+
+
+
?
?
?
+
?
+
+
+
?
?
+
?
?
?
?
+
?
?
?
+
?
?
?
+
?
?
?
?
?
?
?
+
+
?
?
?
+
?
+
+
?
+
+
?
?
+
?
+
+
+
?
+
?
?
+
?
?
?
+
?
+
?
?
+
?
?
?
?
+
+
?
+
+
?
+
+
?
+
?
+
?
?
+
+
+
+
+
?
?
+
+
+
?
?
+
+
+
?
+
?
+
+
?
?
394
0
394
0
394
394
394
394
394
0
0
394
0
394
0
394
394
394
0
0
394
394
0
0
0
0
394
394
0
0
0
394
0
394
394
0
0
394
0
0
0
0
0
0
394
0
394
394
0
0
394
0
394
0
394
394
394
0
394
394
394
394
0
394
0
394
394
0
394
394
394
394
394
0
394
394
394
394
0
0
394
394
394
0
0
394
0
394
394
394
0
394
0
394
394
0
394
394
0
0
0
0
394
394
394
394
394
0
394
394
0
394
394
394
0
394
394
0
394
0
0
394
394
394
394
394
394
0
0
394
394
394
394
394
394
394
0
0
394
394
394
394
0
394
0
394
394
394
0
0
0.004
ns
0.008
ns
-0.007
0.011
0.004
0.003
0.005
ns
ns
-0.011
ns
0.004
ns
0.002
0.003
0.002
ns
ns
-0.004
0.003
ns
ns
ns
ns
-0.010
0.001
ns
ns
ns
0.000
ns
-0.013
-0.012
ns
ns
0.001
ns
ns
ns
ns
ns
ns
-0.011
ns
0.002
0.009
ns
ns
-0.003
ns
0.009
ns
-0.004
0.006
0.008
ns
0.010
0.013
-0.003
-0.002
ns
-0.005
ns
-0.011
0.004
ns
-0.009
0.011
0.007
-0.007
0.004
ns
-0.003
-0.007
-0.001
0.004
ns
ns
-0.009
0.007
-0.011
ns
ns
-0.006
ns
0.000
0.007
0.000
ns
0.004
ns
-0.001
-0.007
ns
-0.006
0.008
ns
ns
ns
ns
0.005
-0.005
-0.002
0.004
-0.005
ns
0.004
0.004
ns
-0.007
0.000
0.004
ns
-0.007
0.001
ns
0.003
ns
ns
-0.003
0.008
0.001
0.004
0.009
0.009
ns
ns
-0.006
-0.004
0.001
-0.002
0.005
0.001
-0.010
ns
ns
0.010
0.001
-0.005
0.010
ns
0.012
ns
0.012
0.010
-0.001
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
ns
ns
0.003
0.004
ns
ns
ns
0.003
ns
0.003
0.003
ns
ns
0.003
ns
ns
ns
ns
ns
ns
0.003
ns
0.003
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.004
0.003
ns
0.003
0.003
0.003
0.003
ns
0.004
ns
0.003
0.004
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
ns
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
ns
0.003
0.004
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.004
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
ns
2.49E-01
ns
1.18E-02
ns
5.45E-02
4.88E-04
2.82E-01
3.21E-01
8.39E-02
ns
ns
7.51E-04
ns
2.05E-01
ns
5.37E-01
4.33E-01
5.38E-01
ns
ns
1.64E-01
4.32E-01
ns
ns
ns
ns
2.52E-03
8.25E-01
ns
ns
ns
8.83E-01
ns
1.81E-04
2.98E-04
ns
ns
8.39E-01
ns
ns
ns
ns
ns
ns
5.76E-04
ns
6.16E-01
2.57E-03
ns
ns
3.73E-01
ns
1.80E-03
ns
1.69E-01
9.37E-02
9.59E-03
ns
2.34E-04
1.53E-04
3.21E-01
6.02E-01
ns
1.34E-01
ns
1.78E-04
3.01E-01
ns
4.03E-04
1.55E-04
3.05E-02
1.77E-02
2.44E-01
ns
3.92E-01
3.93E-02
8.32E-01
2.10E-01
ns
ns
2.74E-03
1.86E-02
4.82E-04
ns
ns
4.79E-02
ns
9.50E-01
1.36E-02
9.99E-01
ns
1.52E-01
ns
7.19E-01
4.54E-02
ns
7.71E-02
1.95E-02
ns
ns
ns
ns
8.55E-02
7.45E-02
4.77E-01
2.62E-01
1.28E-01
ns
1.61E-01
1.57E-01
ns
3.65E-02
9.90E-01
2.08E-01
ns
1.37E-02
8.28E-01
ns
4.22E-01
ns
ns
3.56E-01
1.97E-02
6.71E-01
1.79E-01
4.87E-03
5.40E-03
ns
ns
4.19E-02
2.45E-01
8.62E-01
5.51E-01
1.51E-01
8.09E-01
1.05E-03
ns
ns
1.96E-03
7.30E-01
8.07E-02
9.93E-04
ns
4.68E-06
ns
4.60E-04
1.09E-03
8.44E-01
ns
ns
+
?
+
?
+
+
+
+
?
?
?
+
?
+
+
?
+
+
?
?
?
+
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
+
?
+
+
?
+
+
?
?
+
?
+
+
+
?
+
?
?
+
+
?
?
?
+
?
+
+
+
+
?
?
?
?
?
+
+
?
+
+
?
+
+
+
?
?
?
+
+
+
+
+
+
+
?
+
+
?
+
+
?
?
+
+
?
+
?
+
+
+
?
394
0
394
0
394
394
394
394
394
0
0
394
0
394
0
394
394
394
0
394
394
394
0
0
394
0
394
394
0
0
0
394
0
394
394
0
0
394
0
0
0
0
0
0
394
0
0
394
0
0
394
0
394
0
394
394
394
0
394
394
394
394
0
394
0
394
394
0
394
394
394
394
394
0
394
394
394
394
0
0
394
394
394
0
0
394
0
394
394
394
0
394
394
394
394
0
394
394
0
0
0
0
394
394
394
394
394
0
394
394
0
394
394
394
0
394
394
0
394
0
394
394
394
394
394
394
394
394
0
394
394
394
394
0
394
394
0
0
394
394
394
394
0
394
0
394
394
394
394
0
0.008
ns
0.016
ns
-0.001
0.001
0.008
0.007
0.008
ns
ns
-0.001
ns
0.007
ns
0.004
0.008
-0.004
ns
0.005
-0.010
0.012
ns
ns
-0.008
ns
0.012
-0.005
ns
ns
ns
0.009
ns
-0.015
-0.011
ns
ns
-0.001
ns
ns
ns
ns
ns
ns
-0.003
ns
ns
0.017
ns
ns
-0.003
ns
0.010
ns
-0.002
0.010
0.017
ns
0.011
0.014
-0.008
-0.013
ns
-0.005
ns
0.006
-0.003
ns
-0.007
0.015
0.008
-0.007
0.012
ns
-0.001
-0.004
-0.002
0.013
ns
ns
-0.022
0.003
0.015
ns
ns
-0.012
ns
-0.003
0.015
-0.006
ns
0.007
0.004
0.019
0.001
ns
-0.008
-0.001
ns
ns
ns
ns
0.006
-0.009
-0.010
0.008
-0.020
ns
0.008
0.002
ns
0.001
0.010
0.007
ns
-0.014
-0.003
ns
-0.005
ns
0.007
0.011
0.014
-0.001
0.010
0.011
0.008
0.011
ns
-0.011
-0.004
0.007
0.011
ns
0.010
0.002
ns
ns
-0.008
0.010
-0.001
0.010
ns
0.010
ns
0.011
0.000
0.008
0.021
ns
0.003
ns
0.003
ns
0.003
0.004
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
ns
ns
ns
0.003
ns
0.003
0.003
ns
ns
0.003
ns
ns
ns
ns
ns
ns
0.003
ns
ns
0.003
ns
ns
0.003
ns
0.003
ns
0.004
0.003
0.003
ns
0.002
0.003
0.003
0.003
ns
0.003
ns
0.003
0.004
ns
0.002
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
ns
ns
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
0.003
0.003
0.003
ns
0.003
0.004
ns
ns
0.003
0.003
0.003
0.003
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
1.24E-02
ns
3.60E-06
ns
6.68E-01
8.46E-01
6.43E-03
4.37E-02
1.74E-02
ns
ns
6.77E-01
ns
2.35E-02
ns
2.03E-01
1.56E-02
2.14E-01
ns
9.59E-02
8.98E-04
9.34E-05
ns
ns
2.12E-02
ns
3.68E-04
1.21E-01
ns
ns
ns
1.88E-03
ns
3.50E-06
8.72E-04
ns
ns
7.22E-01
ns
ns
ns
ns
ns
ns
4.22E-01
ns
ns
1.46E-07
ns
ns
3.62E-01
ns
2.36E-04
ns
6.33E-01
2.39E-03
3.47E-10
ns
2.86E-05
9.68E-06
8.38E-03
1.23E-04
ns
1.61E-01
ns
6.08E-02
4.37E-01
ns
3.64E-03
5.63E-08
1.09E-02
3.59E-02
3.35E-04
ns
7.48E-01
2.40E-01
4.24E-01
4.93E-05
ns
ns
1.74E-13
2.42E-01
1.44E-06
ns
ns
2.09E-04
ns
3.70E-01
8.06E-08
7.54E-02
ns
2.87E-02
1.74E-01
4.66E-11
7.23E-01
ns
1.25E-02
6.77E-01
ns
ns
ns
ns
5.31E-02
3.73E-03
7.68E-04
2.20E-02
3.38E-08
ns
8.21E-03
5.05E-01
ns
8.17E-01
1.01E-03
3.84E-02
ns
7.52E-06
3.84E-01
ns
1.45E-01
ns
6.13E-02
3.57E-04
3.47E-05
6.67E-01
5.63E-03
1.85E-04
1.70E-02
1.44E-03
ns
1.27E-04
3.03E-01
2.70E-02
1.63E-03
ns
3.05E-03
6.16E-01
ns
ns
2.55E-02
3.54E-04
8.05E-01
1.09E-03
ns
5.66E-04
ns
1.44E-03
8.75E-01
6.09E-03
8.21E-11
ns
--?
?++
++
?-+-++
-+?+
?-++
+-+
?+
+-++-+
++
-++
++
---+
?+?
-+?++?
-+
++-++
++
-+++
-?
+?
?+
?
++
++++
?++++?+++
--+
-?+
++
???+++-++++??+
+-+
+?
+?
+?++
---?+
?+
+-++
--?
-?
+?
++-+-+
+++
++
++
--+++
-+
?+
--+
-?
+-+
+?+
?-+
+?+-+
++
+++
-??-?+++
++
-+-+-++++
-+--
515
302
213
515
515
213
515
515
515
515
515
515
213
213
515
515
515
515
213
515
515
515
515
515
515
515
515
515
515
515
515
213
302
515
515
213
515
302
515
515
515
515
515
515
515
515
515
302
302
213
0
515
515
515
515
213
515
515
515
515
213
515
515
515
515
515
213
515
213
213
213
515
515
515
515
515
515
515
515
213
213
515
515
302
302
515
213
515
515
515
515
213
213
515
515
515
515
302
302
302
515
515
515
515
515
515
515
515
515
515
515
515
515
515
213
515
515
302
515
515
515
213
213
515
515
213
515
515
515
515
515
515
213
213
515
213
515
515
515
515
515
515
515
515
515
515
515
515
515
515
-1.142
-1.122
-0.279
5.289
1.220
-1.198
-0.513
-0.619
-1.071
2.048
-1.331
-0.251
2.625
-0.976
-1.534
2.506
-0.940
-0.476
1.951
0.798
-1.332
0.956
-0.181
0.092
2.240
-3.312
2.457
1.685
-1.381
-1.150
-0.054
-0.483
1.003
-1.591
-1.331
-1.454
-0.436
1.960
0.265
1.325
-2.373
-0.783
2.010
0.574
-0.445
0.011
1.838
-1.969
1.011
2.030
ns
4.677
0.165
0.811
4.956
-1.603
-0.127
-0.365
-0.357
-0.591
-0.964
-0.524
2.581
-1.097
-0.714
-0.499
0.001
3.852
-1.195
-1.621
-2.527
-0.985
0.748
0.410
-0.748
-0.675
-1.014
0.045
-0.598
-0.112
0.295
0.299
0.151
1.691
0.468
-0.276
-0.940
1.719
-0.156
-1.491
-1.344
0.015
0.246
-1.020
-0.211
2.208
-0.367
-0.204
-1.112
1.882
0.353
0.577
-1.715
-0.443
0.494
0.310
3.205
1.738
2.029
-1.681
-2.633
-1.860
4.189
0.361
0.406
-0.815
0.074
-2.315
-0.791
-0.548
0.403
1.946
-1.752
-0.331
2.081
-1.323
-0.678
-0.440
3.638
-0.208
1.695
-1.778
-0.136
-0.071
-0.819
-1.559
-0.025
2.091
2.287
-2.036
-0.115
-1.307
-0.918
-1.341
-0.473
0.048
1.505
-2.110
-1.875
-3.201
2.54E-01
2.62E-01
7.80E-01
1.23E-07
2.22E-01
2.31E-01
6.08E-01
5.36E-01
2.84E-01
4.06E-02
1.83E-01
8.02E-01
8.67E-03
3.29E-01
1.25E-01
1.22E-02
3.47E-01
6.34E-01
5.11E-02
4.25E-01
1.83E-01
3.39E-01
8.57E-01
9.27E-01
2.51E-02
9.27E-04
1.40E-02
9.20E-02
1.67E-01
2.50E-01
9.57E-01
6.29E-01
3.16E-01
1.12E-01
1.83E-01
1.46E-01
6.63E-01
5.00E-02
7.91E-01
1.85E-01
1.77E-02
4.34E-01
4.45E-02
5.66E-01
6.56E-01
9.91E-01
6.60E-02
4.89E-02
3.12E-01
4.24E-02
ns
2.91E-06
8.69E-01
4.18E-01
7.20E-07
1.09E-01
8.99E-01
7.15E-01
7.21E-01
5.55E-01
3.35E-01
6.00E-01
9.86E-03
2.73E-01
4.75E-01
6.18E-01
9.99E-01
1.17E-04
2.32E-01
1.05E-01
1.15E-02
3.24E-01
4.55E-01
6.82E-01
4.55E-01
5.00E-01
3.11E-01
9.64E-01
5.50E-01
9.11E-01
7.68E-01
7.65E-01
8.80E-01
9.08E-02
6.40E-01
7.83E-01
3.47E-01
8.56E-02
8.76E-01
1.36E-01
1.79E-01
9.88E-01
8.06E-01
3.08E-01
8.33E-01
2.73E-02
7.13E-01
8.38E-01
2.66E-01
5.99E-02
7.24E-01
5.64E-01
8.63E-02
6.58E-01
6.21E-01
7.57E-01
1.35E-03
8.22E-02
4.24E-02
9.28E-02
8.46E-03
6.29E-02
2.80E-05
7.18E-01
6.85E-01
4.15E-01
9.41E-01
2.06E-02
4.29E-01
5.84E-01
6.87E-01
5.16E-02
7.97E-02
7.41E-01
3.74E-02
1.86E-01
4.98E-01
6.60E-01
2.74E-04
8.35E-01
9.01E-02
7.53E-02
8.92E-01
9.43E-01
4.13E-01
1.19E-01
9.80E-01
3.66E-02
2.22E-02
4.18E-02
9.09E-01
1.91E-01
3.59E-01
1.80E-01
6.36E-01
9.61E-01
1.32E-01
3.49E-02
6.08E-02
1.37E-03
+
?
+
+
?
+
+
+
+
?
+
+
?
+
+
+
+
+
+
?
+
?
+
+
+
+
+
+
+
+
+
?
?
+
+
+
?
+
+
?
+
?
+
?
?
?
+
+
+
?
?
?
+
+
?
?
+
+
+
+
+
+
+
?
?
+
?
+
+
+
?
?
?
?
+
+
+
+
+
+
?
299
299
0
299
299
0
299
299
299
299
299
299
299
0
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
0
0
299
299
299
299
0
299
299
299
299
0
299
299
299
299
299
0
299
0
0
0
299
299
299
299
299
299
299
299
0
0
299
299
299
299
299
0
299
299
299
299
0
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
0
299
299
0
299
299
299
299
299
299
0
0
299
0
0
299
299
299
299
299
299
299
299
299
299
299
299
0
-0.002
0.007
ns
0.011
0.006
ns
0.017
-0.005
-0.018
0.002
0.002
-0.010
0.008
ns
-0.006
0.002
0.000
-0.011
ns
0.033
-0.004
0.007
-0.004
0.007
0.006
-0.004
-0.002
0.011
-0.008
-0.015
0.004
ns
0.003
-0.012
-0.008
ns
-0.006
0.010
0.010
0.006
0.004
0.002
0.027
0.008
-0.005
-0.001
0.007
-0.025
0.006
ns
ns
0.001
0.008
-0.002
0.021
ns
-0.012
0.000
0.003
-0.008
ns
-0.006
0.002
-0.007
-0.020
-0.005
ns
0.017
ns
ns
ns
0.002
0.004
-0.012
-0.008
-0.006
-0.005
-0.011
0.001
ns
ns
-0.001
-0.007
-0.007
-0.003
-0.002
ns
0.003
-0.009
-0.003
0.001
ns
ns
-0.003
0.000
0.005
-0.006
-0.007
-0.012
-0.010
0.002
-0.004
-0.004
-0.001
-0.022
-0.002
0.044
0.001
0.025
-0.015
-0.007
-0.025
0.025
-0.008
-0.003
-0.005
0.004
-0.001
-0.012
-0.002
0.000
ns
ns
-0.020
0.011
ns
-0.010
0.018
0.041
-0.009
0.009
-0.013
ns
ns
-0.013
ns
ns
0.023
0.013
-0.012
0.002
-0.003
-0.012
-0.024
-0.021
-0.007
0.021
0.001
0.003
ns
0.006
0.005
ns
0.003
0.005
ns
0.006
0.003
0.004
0.003
0.002
0.004
0.005
ns
0.003
0.005
0.004
0.003
ns
0.007
0.005
0.007
0.002
0.002
0.003
0.002
0.007
0.007
0.005
0.004
0.007
ns
0.004
0.006
0.005
ns
0.003
0.005
0.006
0.007
0.002
0.003
0.010
0.005
0.002
0.002
0.005
0.005
0.004
ns
ns
0.002
0.004
0.006
0.007
ns
0.005
0.002
0.005
0.006
ns
0.005
0.004
0.008
0.006
0.005
ns
0.005
ns
ns
ns
0.003
0.006
0.006
0.006
0.004
0.003
0.004
0.004
ns
ns
0.006
0.003
0.004
0.008
0.006
ns
0.003
0.005
0.005
0.002
ns
ns
0.004
0.006
0.003
0.003
0.003
0.003
0.005
0.002
0.006
0.005
0.003
0.004
0.003
0.014
0.003
0.005
0.005
0.002
0.008
0.007
0.006
0.002
0.002
0.004
0.002
0.005
0.003
0.002
ns
ns
0.004
0.007
ns
0.007
0.013
0.009
0.007
0.006
0.002
ns
ns
0.004
ns
ns
0.008
0.005
0.004
0.006
0.002
0.006
0.006
0.005
0.003
0.005
0.003
0.003
ns
6.93E-01
1.36E-01
ns
1.93E-05
1.85E-01
ns
4.74E-03
1.19E-01
1.05E-05
4.66E-01
4.57E-01
1.19E-02
9.00E-02
ns
3.47E-02
6.13E-01
9.43E-01
7.52E-04
ns
1.78E-05
3.73E-01
2.87E-01
9.29E-02
4.34E-03
3.95E-02
6.56E-02
7.38E-01
1.24E-01
6.16E-02
2.64E-04
5.98E-01
ns
5.18E-01
3.57E-02
1.09E-01
ns
5.23E-02
4.95E-02
7.96E-02
3.83E-01
1.49E-01
6.37E-01
5.93E-03
1.07E-01
3.97E-03
6.33E-01
1.52E-01
3.57E-07
1.62E-01
ns
ns
6.25E-01
7.72E-02
7.31E-01
1.63E-03
ns
2.17E-02
8.14E-01
5.77E-01
2.20E-01
ns
2.27E-01
6.19E-01
4.25E-01
1.35E-03
3.11E-01
ns
5.56E-04
ns
ns
ns
3.72E-01
4.99E-01
6.26E-02
1.67E-01
1.05E-01
1.01E-01
8.55E-03
7.38E-01
ns
ns
9.09E-01
2.74E-02
1.00E-01
7.53E-01
6.59E-01
ns
3.64E-01
8.58E-02
5.05E-01
4.92E-01
ns
ns
4.66E-01
9.58E-01
6.71E-02
5.17E-02
7.69E-03
4.83E-04
4.34E-02
2.75E-01
4.79E-01
4.70E-01
6.05E-01
2.23E-07
6.09E-01
2.24E-03
6.37E-01
2.00E-06
1.44E-03
1.34E-03
2.66E-03
3.03E-04
1.80E-01
1.01E-01
3.40E-03
3.13E-01
5.81E-01
2.91E-02
4.85E-01
8.29E-01
ns
ns
1.46E-05
1.32E-01
ns
1.37E-01
1.58E-01
9.99E-06
2.41E-01
1.29E-01
6.01E-08
ns
ns
1.71E-03
ns
ns
2.14E-03
5.46E-03
6.37E-03
7.96E-01
1.81E-01
5.03E-02
9.86E-05
5.06E-05
1.06E-02
4.85E-05
6.42E-01
2.87E-01
ns
-+
?-+
+-+?
-+
++
+++-+-+
++
+-+?
+?
-+
+-+
-?
---+
-++
-+
-+
-+
-?-+
---?+
--+
-+
--+
-+
++
-+
++
??++
?+
+?
-+
---+
++
-+
-+
-+
--+?
-+?
-++--+
---+
++
-+?
-+--+
--+
++
??+
-+?
++
++
-+
-+?
-+
++
---?+
?
?
-+
-+-+-++
+++
--?
--+
-+
+?
--?
-++
+?
++
-+---+
-+
++
-++?
+--+
-?
-?
-+
++
-?
--+
-+
++
--++
-+?
+?
567
354
567
567
567
213
567
567
567
567
567
567
567
567
567
567
567
213
213
567
567
567
213
567
567
567
567
567
567
567
567
567
354
567
567
567
567
354
567
567
567
567
567
567
567
567
567
354
354
567
354
213
567
567
567
567
567
567
567
567
567
567
213
567
213
567
567
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
354
354
567
213
567
567
567
567
213
567
567
567
567
567
354
0
0
567
567
567
567
567
567
567
567
567
567
213
567
567
567
213
567
567
0
567
567
213
567
567
567
567
567
567
567
567
567
567
213
567
567
567
213
213
567
567
213
567
567
567
567
567
567
567
567
213
213
1.085
-0.654
0.126
1.151
-2.035
0.885
0.830
1.510
0.375
0.170
-0.527
-1.617
1.284
0.291
0.291
-0.059
-1.011
1.487
1.555
1.495
0.607
1.967
-2.158
-1.405
-0.714
-0.970
-2.255
2.217
-0.071
0.510
3.151
-2.185
-0.455
0.213
-4.474
-0.685
-3.194
2.105
-2.157
-0.461
0.313
-2.776
0.085
1.846
1.453
-0.657
1.693
-3.427
-0.607
1.785
0.222
2.400
0.711
-2.290
-0.634
1.633
2.086
1.306
0.569
-0.532
-3.332
-4.404
2.824
-2.294
3.285
-2.373
0.271
0.691
-4.312
-0.895
-1.874
-3.446
-0.981
3.110
-2.009
0.167
-3.081
-0.900
-1.738
1.551
-1.549
1.462
1.745
-1.276
0.564
-3.135
1.683
3.313
1.147
0.126
-0.131
1.502
-0.424
2.378
-0.555
-1.200
-3.659
0.852
ns
ns
-0.251
-1.885
-0.021
-2.911
0.414
-1.627
3.326
-0.570
2.710
-2.118
-1.180
-4.508
0.749
1.221
2.783
-1.948
-2.299
ns
-3.848
1.044
0.721
1.668
-2.215
-1.645
-2.964
-1.334
0.591
-0.591
2.814
-1.715
1.657
0.695
-1.779
-0.713
-0.523
-1.946
-2.447
0.753
3.069
-2.287
-4.354
-0.144
0.159
0.630
-1.944
-1.966
3.342
-1.714
0.607
1.092
2.78E-01
5.13E-01
9.00E-01
2.50E-01
4.19E-02
3.76E-01
4.07E-01
1.31E-01
7.08E-01
8.65E-01
5.98E-01
1.06E-01
1.99E-01
7.71E-01
7.71E-01
9.53E-01
3.12E-01
1.37E-01
1.20E-01
1.35E-01
5.44E-01
4.92E-02
3.09E-02
1.60E-01
4.75E-01
3.32E-01
2.41E-02
2.67E-02
9.44E-01
6.10E-01
1.63E-03
2.89E-02
6.49E-01
8.31E-01
7.68E-06
4.94E-01
1.40E-03
3.53E-02
3.10E-02
6.45E-01
7.55E-01
5.50E-03
9.32E-01
6.48E-02
1.46E-01
5.11E-01
9.05E-02
6.11E-04
5.44E-01
7.42E-02
8.24E-01
1.64E-02
4.77E-01
2.20E-02
5.26E-01
1.02E-01
3.69E-02
1.92E-01
5.69E-01
5.95E-01
8.61E-04
1.07E-05
4.74E-03
2.18E-02
1.02E-03
1.76E-02
7.87E-01
4.89E-01
1.62E-05
3.71E-01
6.09E-02
5.70E-04
3.26E-01
1.87E-03
4.46E-02
8.67E-01
2.07E-03
3.68E-01
8.22E-02
1.21E-01
1.22E-01
1.44E-01
8.10E-02
2.02E-01
5.73E-01
1.72E-03
9.23E-02
9.23E-04
2.51E-01
9.00E-01
8.96E-01
1.33E-01
6.72E-01
1.74E-02
5.79E-01
2.30E-01
2.53E-04
3.94E-01
ns
ns
8.02E-01
5.94E-02
9.83E-01
3.61E-03
6.79E-01
1.04E-01
8.81E-04
5.69E-01
6.73E-03
3.42E-02
2.38E-01
6.54E-06
4.54E-01
2.22E-01
5.39E-03
5.14E-02
2.15E-02
ns
1.19E-04
2.97E-01
4.71E-01
9.53E-02
2.68E-02
9.99E-02
3.04E-03
1.82E-01
5.55E-01
5.55E-01
4.89E-03
8.64E-02
9.75E-02
4.87E-01
7.53E-02
4.76E-01
6.01E-01
5.17E-02
1.44E-02
4.52E-01
2.15E-03
2.22E-02
1.34E-05
8.86E-01
8.74E-01
5.29E-01
5.19E-02
4.93E-02
8.32E-04
8.66E-02
5.44E-01
2.75E-01
?
+
?
?
+
?
+
+
+
+
+
?
+
+
+
+
+
+
+
?
+
+
+
+
?
+
?
+
+
?
+
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
?
?
+
+
+
+
+
?
+
?
+
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
?
?
+
+
+
+
+
+
+
?
0
869
869
0
869
0
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
0
869
869
0
869
869
869
869
869
869
0
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
0
869
869
869
869
869
869
869
869
869
869
869
869
0
869
0
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
0
869
869
869
869
869
869
869
869
869
869
0
ns
0.000
0.000
ns
-0.001
ns
0.003
-0.001
-0.002
ns
-0.003
0.005
0.000
0.002
0.006
0.003
0.002
-0.002
ns
0.000
0.000
-0.002
-0.005
0.002
0.004
-0.001
0.001
0.005
-0.002
-0.003
-0.001
-0.002
0.002
-0.002
0.003
0.003
-0.003
ns
-0.001
0.000
0.000
0.003
-0.001
0.006
-0.001
-0.002
0.001
ns
-0.002
0.000
ns
-0.001
-0.003
0.000
-0.004
0.008
-0.001
ns
0.002
0.002
0.003
0.003
ns
0.002
-0.002
0.003
0.000
0.003
-0.002
0.001
-0.002
0.005
0.004
-0.002
0.006
-0.001
0.003
0.000
0.001
-0.002
0.005
-0.001
ns
-0.001
ns
0.000
0.000
0.003
0.001
0.001
0.003
-0.001
-0.001
-0.002
0.000
-0.001
0.000
ns
0.001
ns
-0.001
0.006
0.001
0.000
0.003
ns
0.006
-0.002
-0.001
-0.003
0.001
0.003
0.002
0.001
-0.001
-0.005
0.003
0.000
-0.002
-0.004
-0.002
0.001
0.003
0.000
0.001
0.002
0.002
-0.005
0.000
-0.001
-0.007
0.000
0.001
-0.002
0.003
0.002
-0.007
ns
ns
0.004
-0.002
-0.003
0.002
0.000
0.000
0.002
0.003
0.005
0.012
ns
ns
0.001
0.001
ns
0.002
ns
0.001
0.000
0.001
ns
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.002
0.001
0.001
0.002
0.002
0.002
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.002
0.001
0.001
0.001
0.002
ns
0.001
0.001
0.001
0.001
0.001
0.002
0.004
0.001
0.001
ns
0.001
0.001
ns
0.001
0.001
0.001
0.002
0.001
0.001
ns
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
ns
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
ns
0.001
0.003
0.001
0.001
0.001
ns
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.000
0.001
0.002
0.004
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.002
0.001
0.003
0.001
0.001
0.001
0.002
ns
ns
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.002
0.001
0.004
ns
ns
8.12E-01
5.31E-01
ns
4.66E-01
ns
5.22E-03
3.97E-04
2.02E-02
ns
1.45E-01
2.16E-04
8.49E-01
8.80E-02
7.75E-06
2.58E-02
3.72E-04
8.23E-03
ns
8.18E-01
9.69E-01
1.15E-01
1.98E-02
3.44E-01
1.19E-01
5.21E-01
3.53E-01
5.36E-04
5.80E-02
3.28E-02
7.41E-01
6.33E-02
1.48E-01
8.41E-02
2.83E-06
1.15E-03
6.71E-02
ns
1.40E-01
9.13E-01
7.02E-01
2.15E-02
3.00E-01
2.04E-03
7.46E-01
4.41E-02
2.20E-01
ns
7.57E-02
7.79E-01
ns
2.29E-01
1.08E-02
7.55E-01
1.45E-02
1.51E-11
3.50E-01
ns
2.93E-02
1.14E-01
1.83E-03
1.67E-02
ns
4.54E-02
1.10E-03
1.61E-04
7.45E-01
4.25E-02
1.79E-02
2.59E-01
1.80E-03
9.69E-05
1.38E-04
3.45E-02
1.23E-07
3.24E-01
8.24E-03
9.47E-01
7.06E-01
1.10E-01
7.81E-05
5.62E-02
ns
8.47E-02
ns
6.73E-01
3.91E-01
9.44E-06
4.47E-01
1.74E-01
4.22E-04
3.60E-01
5.92E-01
3.50E-02
7.79E-01
3.82E-01
9.64E-01
ns
1.67E-01
ns
3.45E-01
6.35E-02
1.42E-01
5.94E-01
4.87E-04
ns
2.17E-03
1.26E-01
3.25E-01
5.75E-04
5.39E-01
5.93E-03
5.07E-04
4.04E-01
2.88E-01
1.11E-04
1.45E-02
4.23E-01
5.25E-03
9.38E-02
6.26E-01
4.85E-02
9.88E-03
9.36E-01
6.63E-01
2.68E-02
9.28E-03
1.15E-02
9.23E-01
2.10E-01
2.49E-04
4.68E-01
8.64E-01
1.32E-01
7.59E-02
2.06E-02
4.85E-05
ns
ns
4.27E-04
4.28E-02
8.45E-04
5.39E-03
9.19E-01
9.69E-01
7.21E-02
1.44E-01
2.40E-04
1.39E-03
ns
?
?
?
+
?
?
?
?
?
+
?
?
+
?
?
+
?
?
?
?
+
?
+
?
+
?
?
?
+
?
?
+
?
?
?
?
?
+
?
+
+
?
?
?
?
?
?
?
?
+
?
?
?
+
?
?
?
?
?
?
?
+
?
?
+
?
?
?
+
?
?
+
?
?
?
?
?
?
?
+
+
+
?
+
?
?
?
+
?
+
+
?
?
+
?
?
+
?
?
?
+
?
?
?
?
+
?
?
+
?
?
0
0
1244
0
1244
1244
0
0
0
0
0
1244
1244
0
0
1244
0
0
1244
0
0
0
1244
0
1244
0
1244
1244
1244
0
1244
0
0
1244
1244
0
1244
1244
1244
0
0
1244
1244
0
0
0
0
1244
0
1244
1244
0
1244
1244
1244
0
1244
0
0
0
1244
0
0
0
0
1244
1244
1244
1244
0
0
0
1244
1244
1244
0
0
1244
0
1244
0
0
0
0
1244
0
0
1244
0
0
0
1244
1244
0
0
1244
0
0
1244
0
0
0
0
1244
1244
0
1244
1244
1244
0
1244
1244
1244
1244
0
0
0
1244
0
1244
1244
0
1244
0
1244
0
1244
0
1244
1244
0
0
0
1244
1244
0
0
0
0
1244
1244
0
1244
1244
0
1244
1244
1244
0
0
ns
ns
-0.001
ns
0.003
-0.001
ns
ns
ns
ns
ns
-0.001
0.000
ns
ns
0.002
ns
ns
0.002
ns
ns
ns
-0.001
ns
0.001
ns
0.001
0.000
-0.001
ns
0.006
ns
ns
-0.002
-0.001
ns
-0.001
0.002
0.000
ns
ns
0.000
0.003
ns
ns
ns
ns
-0.001
ns
0.001
0.000
ns
0.001
-0.001
0.003
ns
-0.001
ns
ns
ns
-0.001
ns
ns
ns
ns
-0.001
-0.001
0.005
0.000
ns
ns
ns
0.000
0.000
-0.001
ns
ns
-0.001
ns
-0.001
ns
ns
ns
ns
0.001
ns
ns
0.001
ns
ns
ns
-0.001
0.001
ns
ns
0.001
ns
ns
-0.001
ns
ns
ns
ns
-0.001
-0.001
ns
0.003
0.001
0.003
ns
-0.001
-0.002
0.003
-0.001
ns
ns
ns
0.000
ns
0.001
0.000
ns
-0.001
ns
0.001
ns
-0.001
ns
0.003
0.000
ns
ns
ns
0.001
-0.002
ns
ns
ns
ns
-0.001
0.001
ns
-0.002
-0.001
ns
0.000
0.001
-0.001
ns
ns
ns
ns
0.000
ns
0.001
0.000
ns
ns
ns
ns
ns
0.000
0.001
ns
ns
0.000
ns
ns
0.001
ns
ns
ns
0.000
ns
0.000
ns
0.000
0.000
0.000
ns
0.001
ns
ns
0.000
0.000
ns
0.000
0.000
0.000
ns
ns
0.000
0.001
ns
ns
ns
ns
0.000
ns
0.000
0.000
ns
0.000
0.001
0.000
ns
0.000
ns
ns
ns
0.000
ns
ns
ns
ns
0.000
0.000
0.001
0.000
ns
ns
ns
0.000
0.001
0.000
ns
ns
0.000
ns
0.000
ns
ns
ns
ns
0.000
ns
ns
0.000
ns
ns
ns
0.000
0.000
ns
ns
0.000
ns
ns
0.000
ns
ns
ns
ns
0.000
0.000
ns
0.001
0.000
0.001
ns
0.000
0.000
0.000
0.000
ns
ns
ns
0.000
ns
0.000
0.000
ns
0.000
ns
0.000
ns
0.000
ns
0.001
0.000
ns
ns
ns
0.000
0.000
ns
ns
ns
ns
0.000
0.001
ns
0.000
0.000
ns
0.000
0.000
0.000
ns
ns
ns
ns
6.57E-03
ns
1.48E-09
2.64E-03
ns
ns
ns
ns
ns
4.26E-03
8.95E-01
ns
ns
9.95E-07
ns
ns
8.00E-05
ns
ns
ns
1.78E-03
ns
9.85E-02
ns
3.45E-03
5.16E-01
5.29E-04
ns
1.76E-14
ns
ns
1.51E-05
4.89E-02
ns
7.21E-03
3.45E-11
2.62E-01
ns
ns
1.45E-02
2.35E-07
ns
ns
ns
ns
8.38E-04
ns
4.74E-02
3.51E-01
ns
1.39E-05
5.72E-02
2.30E-11
ns
2.14E-02
ns
ns
ns
1.08E-02
ns
ns
ns
ns
3.83E-02
3.02E-02
3.61E-10
8.77E-02
ns
ns
ns
5.45E-01
4.66E-01
5.25E-05
ns
ns
6.20E-03
ns
2.09E-01
ns
ns
ns
ns
9.79E-05
ns
ns
4.98E-04
ns
ns
ns
6.72E-07
4.99E-08
ns
ns
1.93E-08
ns
ns
1.64E-06
ns
ns
ns
ns
2.34E-03
3.88E-02
ns
2.14E-04
2.83E-05
9.17E-06
ns
2.68E-04
5.12E-08
1.11E-10
5.02E-05
ns
ns
ns
2.54E-01
ns
3.96E-04
5.34E-02
ns
1.04E-01
ns
1.53E-03
ns
8.75E-04
ns
3.53E-06
4.87E-01
ns
ns
ns
1.51E-05
5.59E-09
ns
ns
ns
ns
5.41E-06
3.22E-01
ns
1.66E-04
4.57E-05
ns
1.31E-01
1.93E-03
1.14E-04
ns
ns
++
+?
--+
++
-?
++
-+?
++?
-?
++
-+
-++
+-++
++
-+
++
-?
+-++?
---+
++
-?
+-+
-+
+++?
+?
++
++
-++
++
++
++
++?
++
++
-?
-?
+-+
++
--+
-+
----+
++
--?
-+
-+
++
-+
--?
-++-+
-+
+-+
-+
-++-?
++
+?
-+
-+
++
--++
-?
+?
+-?
++
+-?
--?
++
-++
++
-+
-+
-+
++
++
++
+-+
++
-+
+?
-++
+?
-++
-+
++
++
-+
++
-?
-+
+++
--+
-?
++
++
-+
-+
+?
++
++
-+
-+
-?
--++
-+
++
-+
-+
-?
362
134
362
362
362
134
362
362
134
362
134
134
362
362
362
362
362
362
362
362
362
362
134
362
362
362
134
362
362
362
362
134
362
362
362
362
362
134
134
362
362
362
362
362
362
362
362
134
362
362
134
134
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
134
362
134
362
362
362
362
362
362
134
134
362
134
362
362
134
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
134
362
362
362
362
362
362
362
134
362
362
362
362
362
134
362
362
362
362
134
362
362
362
362
134
362
362
362
362
362
362
362
134
0.698
0.049
-1.752
3.551
1.082
-1.603
2.237
-1.666
0.590
-1.070
0.332
-1.180
1.305
-1.057
-2.048
1.119
-0.748
-1.270
2.286
1.679
-1.444
0.770
-0.842
-0.631
-1.077
-0.864
0.040
-1.906
-1.919
0.626
1.444
-1.693
-0.147
1.391
-0.287
-0.564
0.004
0.071
0.024
0.598
0.139
-2.299
0.282
0.944
2.082
0.330
-0.229
0.458
0.303
0.798
-2.170
-0.917
-1.500
0.165
1.582
-2.421
-0.941
0.789
-2.766
-1.846
-2.996
-0.092
1.711
-2.600
-2.478
0.394
-0.330
2.015
0.148
-1.605
-1.032
-0.959
-1.101
0.056
0.041
-0.462
-0.686
-1.240
-0.500
-1.721
0.185
-0.406
-1.733
1.669
0.164
-0.200
-1.988
0.291
-1.438
-2.373
1.172
-2.304
0.403
-2.581
-0.815
1.011
-1.487
-1.645
-2.474
-1.468
0.853
-1.321
0.646
0.386
0.030
-0.232
-0.425
0.375
1.359
0.379
-1.079
-1.177
1.675
-0.419
0.434
-2.356
1.021
0.114
-2.012
0.457
0.453
0.326
1.233
-0.278
0.425
-1.032
-0.167
-0.232
0.912
-2.218
1.280
-0.992
1.021
2.288
-1.267
-0.608
0.251
0.485
0.103
-0.265
0.915
-2.105
-2.499
-4.863
0.755
-0.767
1.072
-0.225
0.621
-2.026
4.85E-01
9.61E-01
7.98E-02
3.83E-04
2.79E-01
1.09E-01
2.53E-02
9.58E-02
5.55E-01
2.85E-01
7.40E-01
2.38E-01
1.92E-01
2.90E-01
4.05E-02
2.63E-01
4.54E-01
2.04E-01
2.23E-02
9.31E-02
1.49E-01
4.41E-01
4.00E-01
5.28E-01
2.81E-01
3.88E-01
9.68E-01
5.67E-02
5.49E-02
5.31E-01
1.49E-01
9.05E-02
8.83E-01
1.64E-01
7.74E-01
5.73E-01
9.97E-01
9.43E-01
9.81E-01
5.50E-01
8.89E-01
2.15E-02
7.78E-01
3.45E-01
3.74E-02
7.41E-01
8.19E-01
6.47E-01
7.62E-01
4.25E-01
3.00E-02
3.59E-01
1.34E-01
8.69E-01
1.14E-01
1.55E-02
3.47E-01
4.30E-01
5.68E-03
6.50E-02
2.74E-03
9.26E-01
8.71E-02
9.31E-03
1.32E-02
6.94E-01
7.42E-01
4.40E-02
8.82E-01
1.08E-01
3.02E-01
3.38E-01
2.71E-01
9.56E-01
9.67E-01
6.44E-01
4.93E-01
2.15E-01
6.17E-01
8.52E-02
8.53E-01
6.85E-01
8.31E-02
9.52E-02
8.70E-01
8.41E-01
4.68E-02
7.71E-01
1.51E-01
1.76E-02
2.41E-01
2.12E-02
6.87E-01
9.84E-03
4.15E-01
3.12E-01
1.37E-01
1.00E-01
1.34E-02
1.42E-01
3.94E-01
1.86E-01
5.18E-01
7.00E-01
9.76E-01
8.17E-01
6.71E-01
7.08E-01
1.74E-01
7.05E-01
2.81E-01
2.39E-01
9.39E-02
6.75E-01
6.64E-01
1.85E-02
3.07E-01
9.09E-01
4.43E-02
6.47E-01
6.50E-01
7.44E-01
2.18E-01
7.81E-01
6.71E-01
3.02E-01
8.67E-01
8.17E-01
3.62E-01
2.66E-02
2.00E-01
3.21E-01
3.07E-01
2.21E-02
2.05E-01
5.43E-01
8.02E-01
6.28E-01
9.18E-01
7.91E-01
3.60E-01
3.53E-02
1.25E-02
1.15E-06
4.50E-01
4.43E-01
2.84E-01
8.22E-01
5.35E-01
4.28E-02
33343
36715
68225
2369
54836
61622
42829
6260
32657
43789
63978
42773
56115
41594
53029
56546
46119
61071
50455
36548
39247
65473
11102
59602
43930
15238
18257
40179
18355
11421
68408
38474
21586
60384
28216
32112
60941
2608
61347
21122
12982
56971
47181
34075
42906
60990
1230
47125
38625
18819
668
60879
47922
23906
16252
65723
58212
67815
7273
18981
35734
66130
38356
50861
67174
65095
23591
18019
60947
36705
33962
217
65270
62239
971
36765
46715
47272
47484
23971
34641
39345
27846
31061
14130
47906
39853
26938
42242
19327
36903
13330
58138
43458
1605
7130
22636
64972
21502
36
16671
47768
34081
12828
48783
40381
53361
32655
8855
42316
63762
257
62334
51510
40229
20032
14814
64794
2546
17706
19629
35520
9763
4734
49929
41579
12336
57880
40714
29296
5792
46845
18351
49221
16515
9255
18810
19687
34179
68072
61616
64004
49089
66602
36300
41008
20146
486
60542
36885
1348
1349
1350
1351
1352
1353
1354
1355
1356
1357
1358
1359
1360
1361
1362
1363
1364
1365
1366
1367
1368
1369
1370
1371
1372
1373
1374
1375
1376
1377
1378
1379
1380
1381
1382
1383
1384
1385
1386
1387
1388
1389
1390
1391
1392
1393
1394
1395
1396
1397
1398
1399
1400
1401
1402
1403
1404
1405
1406
1407
1408
1409
1410
1411
1412
1413
1414
1415
1416
1417
1418
1419
1420
1421
1422
1423
1424
1425
1426
1427
1428
1429
1430
1431
1432
1433
1434
1435
1436
1437
1438
1439
1440
1441
1442
1443
1444
1445
1446
1447
1448
1449
1450
1451
1452
1453
1454
1455
1456
1457
1458
1459
1460
1461
1462
1463
1464
1465
1466
1467
1468
1469
1470
1471
1472
1473
1474
1475
1476
1477
1478
1479
1480
1481
1482
1483
1484
1485
1486
1487
1488
1489
1490
1491
1492
1493
1494
1495
1496
1497
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
3312
10125
30812
11146
10988
91860
5330
1725
1990
53938
7048
10250
79071
6874
1536
3588
10390
201895
171586
9617
6773
2971
313
3386
4668
4436
54765
219285
5920
85453
83930
54934
3635
5125
139065
23053
83478
55781
377
1026
467
2213
170463
56935
84928
1155
11035
10459
1459
34
55026
1653
11343
85450
7957
10424
6156
80705
2000
51123
56916
7556
864
4938
55768
11224
192670
6434
5768
9538
84418
8972
2120
221143
168850
284756
10682
971
7743
80851
150291
8292
2618
7178
25870
153443
8881
54033
3106
51099
3065
5004
26123
64112
5210
2990
29109
113174
2110
54625
51206
9406
23636
407975
22901
91057
123920
10061
7084
65010
6195
11221
649946
23395
55357
5019
2175
57692
64114
8767
3133
26152
908
617
6222
10045
3097
2180
163081
892
29916
26267
51194
2014
5557
1979
23119
23052
7391
51035
388325
7375
9232
6890
51318
11232
23294
3310
84166
25804
HSPA8
RASGRP1
SOX8
GLMN
METAP2
CALML4
PLCB2
DHPS
CELA1
PPIL3
TGFBR2
SRRM1
ELOVL6
TAF4
CYBB
IL10RB
CEPT1
C4orf34
ABHD3
MTRF1
STAT2
GTF3A
AOAH
ICAM4
NAGA
MSH2
TRIM44
SAMD9L
RARRES3
TSPYL5
STARD3NL
KANSL2
INPP5D
PCSK5
SLITRK4
KIAA0913
ARHGAP24
RIOK2
ARF3
CDKN1A
ATF3
FCGR2B
SSBP4
C11orf75
TMEM209
TBCB
RIPK3
MAD2L2
CSNK2A2
ACADM
FAM70A
DDX1
MGLL
ITPRIP
EPM2A
PGRMC2
RPL30
TSGA10
ELF4
ZNF706
SMARCAD1
ZNF10
RUNX3
OAS1
NGLY1
RPL35
EIF2C4
TRA2B
QSOX1
EI24
CYSTM1
MGAM
ETV6
N6AMT2
ZNF800
C20orf197
EBP
CD72
ZNF189
SH3BP5L
MORC2-AS1
COLQ
GART
TPT1
SUMF2
SRFBP1
CDC16
RBM11
HLA-B
ABHD5
HDAC1
ORM1
TCTN3
MOAP1
PFKFB4
GUSB
FHOD1
SAAL1
ETFDH
PARP14
GP6
ZRANB2
NUP62
MIR17HG
ARSG
CCDC34
CMTM3
ABCF2
TK2
SLC26A6
RPS6KA1
DUSP10
RPL23AP64
LARS2
TBC1D2
OXCT1
FANCA
MAGEE1
TMBIM1
RIPK2
HLA-E
ZNF337
CCT6A
BCS1L
RPS18
SH2D3A
HIVEP2
ACSL1
ZNF567
CCNC
SNX11
FBXO10
IPO11
EMP3
PRIM1
EIF4EBP2
HIC2
ENDOD1
USF1
UBXN1
SCIMP
USP4
PTTG1
TAP1
MRPL35
POLG2
ANKS1A
HSPA6
NLRC5
LSM4
-----+
--+-----------------++++++
++++-+
----------+
-------+-------+
++++++
-----++++-+
++++++
--+----++++
+-++-+
-----++++++
---+--+++-+
++-+++
++++++
--+-------++++++
++-+++
---+-++++++
-----+++--+
--++-++++-+
++++++
++++++
--+--++++++
++-++++++++
+-++++
++-+++
++++-+
-----++-+++
+++?-+
++-+++
-----+
---?-++--++
-----+++-+++++-+
-------------+--+---++-?++
---?-----------++-+++
-+++++
--+-------+++?-+
-----++++-+
-----+
+-++++
+++--+
++++++
---+------+-++++
++++++
-+--+-----++++++
--------?----------+---?-+
--++-----------++++++
+-++-+
-----+
++++++
----------++++++
++-+++
++--++
-----++++++
++++++
++-++--+-----------+++++++
----+++++++
-----++++-+
++--++
++--++
++-+++
--+-------++++-+
---+-++--++
-----+
+++-++
++++++
++++++
----------+
--------+------+++--+-+-++
-------+-+++++-+
----------++-+++
---?-++-+++
-----+
++--+-+++++
------+++++
-+++++
++-+++
++++-+
-------+--+-++-+
++++++
++-+++
---+--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-5.237
-5.995
-6.026
-5.738
-5.680
5.912
5.303
-5.599
-4.987
-5.890
-5.394
-5.731
5.382
-5.893
5.833
5.745
-5.145
5.572
5.034
-4.912
5.298
-5.139
5.020
4.929
5.802
-5.206
-5.291
5.538
5.882
-5.792
5.794
-5.331
5.028
-4.638
5.041
4.930
5.103
-5.457
5.893
5.616
5.159
5.077
5.071
5.297
-5.473
5.508
5.206
5.326
-4.716
-5.147
4.616
-5.143
5.577
5.101
-5.045
-5.727
-5.696
-4.984
5.775
-4.801
-4.874
-5.149
5.525
5.202
-5.015
-5.143
5.084
-4.681
5.210
-4.997
4.635
5.708
5.277
-5.123
-5.456
5.116
4.864
-4.647
-5.105
5.530
-4.677
-5.594
-5.028
-5.620
-5.211
-5.028
-5.421
-5.457
5.356
4.941
-5.475
4.876
-5.454
-4.604
5.521
5.046
4.635
-5.084
4.903
5.256
4.628
-5.199
-5.012
-4.824
4.949
-5.249
4.773
-4.867
5.225
5.152
5.322
5.270
-5.090
-4.919
5.000
-4.917
4.604
-4.977
4.729
4.631
5.213
-5.084
-4.834
-4.624
-5.149
-4.896
-4.955
4.757
-4.932
-4.794
4.965
-5.025
-4.707
4.626
-5.050
4.982
-4.645
4.614
4.973
-4.655
4.711
4.905
4.610
4.858
-4.820
-4.726
4.729
4.642
4.626
-4.617
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.64E-07
2.04E-09
1.68E-09
9.56E-09
1.35E-08
3.38E-09
1.14E-07
2.15E-08
6.14E-07
3.86E-09
6.90E-08
9.96E-09
7.35E-08
3.79E-09
5.46E-09
9.19E-09
2.67E-07
2.52E-08
4.80E-07
9.04E-07
1.17E-07
2.76E-07
5.17E-07
8.27E-07
6.54E-09
1.94E-07
1.22E-07
3.06E-08
4.05E-09
6.95E-09
6.86E-09
9.76E-08
4.97E-07
3.51E-06
4.62E-07
8.21E-07
3.35E-07
4.84E-08
3.79E-09
1.96E-08
2.48E-07
3.84E-07
3.95E-07
1.18E-07
4.43E-08
3.62E-08
1.93E-07
1.01E-07
2.41E-06
2.65E-07
3.91E-06
2.70E-07
2.44E-08
3.39E-07
4.54E-07
1.02E-08
1.23E-08
6.21E-07
7.71E-09
1.58E-06
1.10E-06
2.61E-07
3.29E-08
1.98E-07
5.32E-07
2.70E-07
3.69E-07
2.85E-06
1.89E-07
5.83E-07
3.56E-06
1.14E-08
1.32E-07
3.01E-07
4.88E-08
3.12E-07
1.15E-06
3.36E-06
3.31E-07
3.20E-08
2.92E-06
2.22E-08
4.95E-07
1.91E-08
1.88E-07
4.97E-07
5.94E-08
4.84E-08
8.49E-08
7.79E-07
4.37E-08
1.08E-06
4.92E-08
4.15E-06
3.37E-08
4.52E-07
3.57E-06
3.71E-07
9.44E-07
1.47E-07
3.69E-06
2.00E-07
5.39E-07
1.41E-06
7.48E-07
1.53E-07
1.81E-06
1.14E-06
1.74E-07
2.58E-07
1.03E-07
1.37E-07
3.59E-07
8.70E-07
5.74E-07
8.78E-07
4.15E-06
6.46E-07
2.26E-06
3.64E-06
1.86E-07
3.69E-07
1.34E-06
3.77E-06
2.63E-07
9.79E-07
7.24E-07
1.96E-06
8.15E-07
1.64E-06
6.87E-07
5.03E-07
2.51E-06
3.72E-06
4.41E-07
6.28E-07
3.40E-06
3.94E-06
6.59E-07
3.24E-06
2.46E-06
9.32E-07
4.03E-06
1.19E-06
1.44E-06
2.29E-06
2.26E-06
3.46E-06
3.73E-06
3.89E-06
--------------+
---+-++-----+---+----++++++++
++---+++
---+-+------+---+------------------+
++-+++++
-----+---++++++
++++++++
---+----++++-++
+++--+-+
--------+++++++
---+---+-+-++++
++++-+++
+++++-++
--+---+----++-++++++++
++++++++
?--+-??+++++--+
-----+-++-+-+++
-----+-+++++-++
++++++++
++-+++++
-++----++-+++++
-+++++++
++++++++
+-++-+++
++++++++
+-+++-++
-------+-++++++
++++++++
++++++++
-----+-+
---+----++---++
--------+++-+++
+++-++-+
----+++-------+
-------?++????++-+++++
--+++--------------+-++-+++++
++++-+++
----+-----++--+++----+
-------++++++-+
-------+++-++++
+++-++-+
++++++++
---+-----+----++++-??+
++++++-+
-+-+--0+
---+-----++++-+
---+-------+---------++-------------+--++-------0---+???++++++++
+-++++-+
-----+-+
+++-++-+
------------+-+
+++-++-+
-+-++-++
++++++++
--++----++--+++
++++++++
-+++++++
----------+--+-+----++++-++-+
-------++++++++
---+---+++++-++
+++-+-++
++--++++
-+---+++
---+---+
-+-----+++-++++
++---+-++++++++
-------+
++-++-++
-+++++++
+-++++++
-----+----+-------------+------+----------+---++-+
-+------+-----++++++++
---?--+--------+++++++
-------++++++++
---+---+
++-++-++
++++++++
-----+-+
-+++++++
-++---++
-++-+-++
-+++++++
-----------+--++++++-+
+++-++++
+++--+++
--+-----
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
4883
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6204
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
7650
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
-5.11
-4.39
-4.36
-4.63
-4.68
4.46
5.03
-4.74
-5.31
-4.45
-4.92
-4.59
4.92
-4.44
4.49
4.55
-5.12
4.70
5.21
-5.32
4.94
-5.09
5.20
5.27
4.44
-5.01
-4.92
4.68
4.34
-4.30
4.41
-4.85
5.14
-5.50
5.12
5.22
5.05
-4.70
4.28
4.54
4.97
5.05
5.04
4.82
-4.65
4.62
4.92
4.78
-5.36
-4.95
5.44
-4.93
4.52
4.97
-5.02
-4.37
-4.40
-5.14
4.36
-5.22
-5.15
-4.88
4.51
4.80
-4.98
-4.84
4.92
-5.27
4.77
-4.97
5.31
4.28
4.68
-4.78
-4.46
4.76
5.02
-5.22
-4.78
4.37
-5.18
-4.36
-4.83
-4.26
-4.66
-4.80
-4.42
-4.32
4.48
4.88
-4.37
4.90
-4.35
-5.14
4.26
4.71
5.09
-4.66
4.82
4.48
5.06
-4.50
-4.67
-4.84
4.72
-4.43
4.88
-4.78
4.44
4.49
4.32
4.35
-4.51
-4.67
4.57
-4.63
4.91
-4.55
4.75
4.83
4.27
-4.37
-4.56
-4.76
-4.25
-4.49
-4.41
4.58
-4.39
-4.52
4.35
-4.27
-4.58
4.66
-4.28
4.29
-4.60
4.60
4.24
-4.52
4.45
4.25
4.51
4.28
-4.28
-4.27
4.27
4.34
4.26
-4.27
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
3.20E-07
1.15E-05
1.33E-05
3.72E-06
2.84E-06
8.31E-06
4.88E-07
2.12E-06
1.09E-07
8.56E-06
8.83E-07
4.36E-06
8.49E-07
9.12E-06
7.05E-06
5.44E-06
3.10E-07
2.56E-06
1.86E-07
1.04E-07
7.71E-07
3.65E-07
2.01E-07
1.34E-07
9.03E-06
5.54E-07
8.54E-07
2.90E-06
1.40E-05
1.73E-05
1.02E-05
1.23E-06
2.81E-07
3.80E-08
3.14E-07
1.84E-07
4.42E-07
2.61E-06
1.86E-05
5.68E-06
6.80E-07
4.54E-07
4.55E-07
1.41E-06
3.29E-06
3.89E-06
8.78E-07
1.74E-06
8.42E-08
7.35E-07
5.41E-08
8.18E-07
6.27E-06
6.83E-07
5.20E-07
1.25E-05
1.09E-05
2.82E-07
1.31E-05
1.81E-07
2.62E-07
1.07E-06
6.48E-06
1.58E-06
6.47E-07
1.29E-06
8.87E-07
1.33E-07
1.83E-06
6.56E-07
1.13E-07
1.86E-05
2.91E-06
1.75E-06
8.07E-06
1.90E-06
5.22E-07
1.83E-07
1.75E-06
1.27E-05
2.25E-07
1.33E-05
1.40E-06
2.07E-05
3.15E-06
1.60E-06
9.76E-06
1.56E-05
7.48E-06
1.09E-06
1.27E-05
9.39E-07
1.39E-05
2.82E-07
2.06E-05
2.49E-06
3.62E-07
3.23E-06
1.45E-06
7.55E-06
4.21E-07
6.91E-06
2.96E-06
1.28E-06
2.39E-06
9.47E-06
1.07E-06
1.73E-06
9.00E-06
6.99E-06
1.56E-05
1.36E-05
6.61E-06
3.05E-06
4.98E-06
3.70E-06
9.31E-07
5.41E-06
2.08E-06
1.37E-06
2.00E-05
1.27E-05
5.14E-06
1.97E-06
2.14E-05
7.30E-06
1.05E-05
4.74E-06
1.12E-05
6.14E-06
1.38E-05
1.94E-05
4.57E-06
3.17E-06
1.89E-05
1.80E-05
4.28E-06
4.16E-06
2.23E-05
6.23E-06
8.49E-06
2.17E-05
6.35E-06
1.91E-05
1.91E-05
1.93E-05
2.00E-05
1.45E-05
2.01E-05
1.98E-05
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
12620
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14385
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
12140
14385
14385
15266
15266
15266
15266
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
13582
15266
15266
15266
15266
15266
14385
15266
15266
14385
15266
15266
13461
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
14907
15266
15266
14385
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
15266
-7.312
-7.311
-7.309
-7.307
-7.307
7.304
7.3
-7.295
-7.285
-7.285
-7.28
-7.279
7.277
-7.277
7.275
7.255
-7.254
7.248
7.247
-7.239
7.233
-7.227
7.226
7.218
7.216
-7.215
-7.213
7.206
7.202
-7.194
7.191
-7.189
7.186
-7.182
7.181
7.176
7.176
-7.166
7.164
7.159
7.155
7.154
7.15
7.146
-7.143
7.142
7.135
7.135
-7.132
-7.121
7.121
-7.118
7.117
7.114
-7.113
-7.113
-7.113
-7.111
7.097
-7.09
-7.089
-7.084
7.076
7.063
-7.062
-7.053
7.052
-7.048
7.048
-7.048
7.038
7.037
7.025
-6.994
-6.994
6.991
6.988
-6.982
-6.982
6.975
-6.974
-6.974
-6.962
-6.958
-6.947
-6.942
-6.941
-6.94
6.938
6.937
-6.937
6.914
-6.908
-6.894
6.891
6.89
6.881
-6.877
6.87
6.867
6.855
-6.842
-6.841
-6.833
6.829
-6.827
6.825
-6.819
6.818
6.807
6.798
6.784
-6.773
-6.772
6.754
-6.742
6.727
-6.726
6.698
6.691
6.683
-6.667
-6.635
-6.633
-6.628
-6.624
-6.608
6.595
-6.582
-6.58
6.572
-6.566
-6.566
6.565
-6.554
6.541
-6.533
6.516
6.5
-6.482
6.473
6.458
6.448
6.446
-6.419
-6.353
6.349
6.341
6.278
-6.274
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.63E-13
2.66E-13
2.69E-13
2.72E-13
2.73E-13
2.78E-13
2.87E-13
2.98E-13
3.22E-13
3.22E-13
3.35E-13
3.37E-13
3.40E-13
3.42E-13
3.46E-13
4.03E-13
4.04E-13
4.22E-13
4.27E-13
4.51E-13
4.73E-13
4.92E-13
4.96E-13
5.28E-13
5.36E-13
5.39E-13
5.47E-13
5.74E-13
5.94E-13
6.31E-13
6.42E-13
6.52E-13
6.66E-13
6.88E-13
6.94E-13
7.15E-13
7.19E-13
7.71E-13
7.84E-13
8.15E-13
8.38E-13
8.41E-13
8.66E-13
8.96E-13
9.15E-13
9.19E-13
9.68E-13
9.70E-13
9.89E-13
1.07E-12
1.07E-12
1.10E-12
1.10E-12
1.13E-12
1.13E-12
1.13E-12
1.14E-12
1.16E-12
1.28E-12
1.35E-12
1.35E-12
1.40E-12
1.48E-12
1.63E-12
1.64E-12
1.75E-12
1.76E-12
1.81E-12
1.82E-12
1.82E-12
1.95E-12
1.97E-12
2.14E-12
2.66E-12
2.67E-12
2.74E-12
2.78E-12
2.91E-12
2.91E-12
3.07E-12
3.07E-12
3.08E-12
3.36E-12
3.44E-12
3.73E-12
3.87E-12
3.91E-12
3.93E-12
3.99E-12
4.00E-12
4.01E-12
4.70E-12
4.92E-12
5.44E-12
5.54E-12
5.60E-12
5.95E-12
6.12E-12
6.41E-12
6.55E-12
7.11E-12
7.83E-12
7.88E-12
8.29E-12
8.57E-12
8.68E-12
8.81E-12
9.17E-12
9.20E-12
9.96E-12
1.06E-11
1.17E-11
1.26E-11
1.27E-11
1.44E-11
1.56E-11
1.73E-11
1.75E-11
2.12E-11
2.22E-11
2.34E-11
2.61E-11
3.25E-11
3.29E-11
3.41E-11
3.50E-11
3.90E-11
4.26E-11
4.64E-11
4.71E-11
4.97E-11
5.16E-11
5.19E-11
5.21E-11
5.60E-11
6.10E-11
6.47E-11
7.23E-11
8.02E-11
9.04E-11
9.59E-11
1.06E-10
1.13E-10
1.15E-10
1.37E-10
2.11E-10
2.16E-10
2.29E-10
3.44E-10
3.52E-10
+
+
?
+
?
+
+
+
+
?
?
+
?
+
+
?
?
?
?
+
?
+
+
?
?
?
+
?
+
?
?
?
?
?
+
?
?
?
?
?
?
+
+
?
?
?
?
?
?
?
?
?
?
+
+
+
+
?
+
?
?
?
+
+
+
+
+
?
?
?
?
?
+
?
+
+
+
?
?
?
?
?
?
?
?
+
+
?
?
?
+
?
+
?
+
+
+
?
?
?
+
+
?
?
?
-
394
394
394
394
394
394
0
394
0
394
394
394
394
394
0
0
394
394
394
0
394
394
0
0
0
0
394
0
394
394
394
394
0
0
0
394
0
394
394
0
0
0
394
0
394
394
0
394
394
0
0
394
394
0
0
394
394
0
0
394
394
394
0
0
394
0
0
394
0
394
394
0
0
394
394
0
0
0
394
394
394
394
394
394
394
394
394
0
394
0
394
0
0
394
394
394
394
394
394
0
0
394
0
0
0
394
0
394
394
394
394
0
394
394
0
394
0
0
0
0
0
0
394
394
394
0
394
394
0
0
394
0
394
394
0
394
394
394
394
394
0
0
0
394
394
0
394
0
0
394
-0.016
-0.003
-0.011
0.003
-0.001
0.014
ns
0.002
ns
0.005
0.001
0.015
-0.013
0.007
ns
ns
0.006
-0.012
-0.006
ns
0.008
0.004
ns
ns
ns
ns
0.004
ns
0.000
-0.010
-0.012
0.010
ns
ns
ns
0.006
ns
0.006
-0.013
ns
ns
ns
-0.010
ns
-0.001
-0.008
ns
-0.008
0.012
ns
ns
-0.007
-0.007
ns
ns
-0.001
-0.006
ns
ns
0.001
-0.001
0.003
ns
ns
-0.006
ns
ns
-0.001
ns
-0.010
-0.007
ns
ns
0.000
-0.002
ns
ns
ns
-0.002
0.003
0.006
0.017
-0.001
-0.005
-0.002
-0.001
0.014
ns
0.001
ns
-0.001
ns
ns
-0.006
0.011
0.012
0.002
0.005
0.001
ns
ns
-0.001
ns
ns
ns
0.003
ns
0.001
0.004
0.008
-0.003
ns
-0.004
-0.009
ns
-0.009
ns
ns
ns
ns
ns
ns
0.000
0.000
-0.005
ns
-0.005
-0.003
ns
ns
0.007
ns
0.005
-0.004
ns
0.005
0.007
-0.007
0.000
0.002
ns
ns
ns
0.004
0.002
ns
-0.003
ns
ns
-0.004
0.003
0.003
0.004
0.003
0.003
0.003
ns
0.003
ns
0.004
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
0.003
0.003
ns
ns
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
ns
ns
0.002
ns
0.003
0.003
ns
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
ns
ns
0.003
ns
0.003
0.003
ns
ns
0.004
0.003
ns
ns
ns
0.004
0.003
0.004
0.003
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
0.003
ns
ns
0.003
0.003
0.002
0.003
0.003
0.003
ns
ns
0.003
ns
ns
ns
0.004
ns
0.003
0.003
0.003
0.004
ns
0.002
0.003
ns
0.003
ns
ns
ns
ns
ns
ns
0.003
0.003
0.003
ns
0.002
0.003
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
ns
ns
0.003
0.003
ns
0.003
ns
ns
0.003
5.33E-06
3.07E-01
1.78E-03
3.66E-01
7.82E-01
4.10E-06
ns
6.22E-01
ns
1.43E-01
7.72E-01
1.99E-06
1.04E-05
4.93E-02
ns
ns
5.77E-02
5.34E-05
1.01E-01
ns
4.75E-03
2.76E-01
ns
ns
ns
ns
1.77E-01
ns
9.80E-01
5.52E-04
1.90E-04
5.13E-03
ns
ns
ns
2.07E-02
ns
1.02E-01
1.77E-05
ns
ns
ns
2.29E-03
ns
7.74E-01
1.87E-02
ns
1.17E-02
4.13E-06
ns
ns
3.19E-02
3.91E-02
ns
ns
8.00E-01
6.62E-02
ns
ns
6.04E-01
7.31E-01
4.56E-01
ns
ns
5.53E-02
ns
ns
7.06E-01
ns
2.97E-04
3.39E-02
ns
ns
9.35E-01
5.20E-01
ns
ns
ns
5.25E-01
3.48E-01
1.17E-01
1.90E-07
7.48E-01
9.77E-02
4.74E-01
8.06E-01
5.51E-05
ns
7.27E-01
ns
7.92E-01
ns
ns
7.01E-02
2.48E-04
5.53E-07
5.25E-01
1.33E-01
8.20E-01
ns
ns
7.60E-01
ns
ns
ns
4.06E-01
ns
7.80E-01
2.55E-01
1.80E-02
3.37E-01
ns
4.98E-02
2.79E-03
ns
2.32E-03
ns
ns
ns
ns
ns
ns
9.11E-01
9.60E-01
1.59E-01
ns
2.17E-02
3.28E-01
ns
ns
4.06E-02
ns
1.49E-01
1.83E-01
ns
1.44E-01
9.18E-03
3.93E-02
8.90E-01
6.05E-01
ns
ns
ns
1.68E-01
5.75E-01
ns
3.68E-01
ns
ns
2.58E-01
?
+
+
?
?
+
?
+
+
+
?
?
+
?
?
+
?
?
?
?
+
?
+
+
?
?
+
+
?
?
?
?
+
+
?
+
?
?
?
?
+
?
?
+
?
?
?
?
+
+
+
?
+
+
+
?
?
?
+
+
?
+
+
+
+
+
?
+
?
+
?
?
+
+
+
+
?
?
+
?
?
?
+
?
+
+
?
?
?
?
?
?
?
+
?
+
?
+
?
?
+
?
+
+
?
+
+
+
?
+
?
?
?
+
+
?
?
?
-
394
0
394
394
394
0
0
394
0
394
394
394
394
394
0
0
394
394
0
0
394
394
0
0
0
0
394
0
394
394
394
394
0
394
0
394
394
394
394
0
0
0
394
0
394
394
0
394
394
0
0
394
394
0
0
394
394
0
0
394
394
394
0
0
394
0
0
394
394
394
394
0
394
394
394
0
0
0
394
394
0
394
394
394
394
394
394
0
394
0
394
0
0
394
394
394
394
394
394
0
0
394
0
0
0
394
0
394
394
0
0
0
394
394
0
394
0
0
0
394
394
0
394
394
394
0
394
394
0
0
394
0
394
394
0
394
394
394
0
394
0
0
0
394
394
0
394
0
0
394
-0.019
ns
0.006
-0.005
0.013
ns
ns
0.005
ns
0.016
-0.003
0.017
-0.006
0.001
ns
ns
0.010
-0.008
ns
ns
0.013
-0.004
ns
ns
ns
ns
0.001
ns
0.019
-0.008
-0.019
0.011
ns
-0.004
ns
0.012
0.003
-0.002
-0.007
ns
ns
ns
-0.015
ns
0.005
0.011
ns
-0.003
0.009
ns
ns
-0.007
-0.020
ns
ns
0.006
-0.002
ns
ns
-0.003
0.003
-0.001
ns
ns
-0.007
ns
ns
0.005
0.002
-0.012
0.001
ns
0.004
0.009
0.002
ns
ns
ns
0.013
0.006
ns
0.012
0.006
-0.008
0.010
0.004
0.009
ns
0.002
ns
0.010
ns
ns
-0.011
0.007
0.012
0.000
0.002
-0.006
ns
ns
0.003
ns
ns
ns
0.005
ns
0.002
0.014
ns
ns
ns
-0.002
-0.001
ns
-0.014
ns
ns
ns
-0.007
0.002
ns
0.001
-0.001
-0.002
ns
-0.013
0.005
ns
ns
0.012
ns
0.004
0.010
ns
0.002
0.010
0.008
ns
0.010
ns
ns
ns
0.009
0.001
ns
-0.006
ns
ns
-0.007
0.003
ns
0.003
0.003
0.003
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
ns
ns
ns
ns
0.003
ns
0.003
0.003
0.003
0.003
ns
0.004
ns
0.002
0.003
0.004
0.003
ns
ns
ns
0.003
ns
0.004
0.003
ns
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
ns
ns
0.003
0.003
0.003
ns
ns
0.003
ns
ns
0.003
0.004
0.002
0.003
ns
0.003
0.003
0.004
ns
ns
ns
0.003
0.003
ns
0.004
0.003
0.003
0.003
0.003
0.003
ns
0.003
ns
0.003
ns
ns
0.003
0.003
0.003
0.003
0.003
0.003
ns
ns
0.003
ns
ns
ns
0.003
ns
0.003
0.003
ns
ns
ns
0.002
0.003
ns
0.003
ns
ns
ns
0.004
0.003
ns
0.003
0.003
0.003
ns
0.002
0.003
ns
ns
0.003
ns
0.003
0.003
ns
0.003
0.002
0.003
ns
0.003
ns
ns
ns
0.003
0.003
ns
0.003
ns
ns
0.003
6.93E-09
ns
7.99E-02
1.36E-01
1.12E-04
ns
ns
9.54E-02
ns
2.45E-06
3.03E-01
6.12E-08
6.16E-02
8.34E-01
ns
ns
4.64E-03
1.00E-02
ns
ns
5.19E-06
2.15E-01
ns
ns
ns
ns
7.34E-01
ns
8.56E-11
1.59E-02
2.80E-09
1.11E-03
ns
2.19E-01
ns
3.03E-07
3.19E-01
6.03E-01
4.15E-02
ns
ns
ns
6.07E-06
ns
1.83E-01
1.21E-03
ns
4.02E-01
3.25E-03
ns
ns
4.17E-02
6.05E-11
ns
ns
1.75E-02
6.24E-01
ns
ns
3.79E-01
3.98E-01
6.97E-01
ns
ns
4.61E-02
ns
ns
8.91E-02
5.85E-01
9.65E-07
7.44E-01
ns
3.06E-01
6.36E-03
5.77E-01
ns
ns
ns
1.17E-04
3.07E-02
ns
1.07E-03
6.23E-02
1.08E-02
2.79E-03
1.97E-01
7.30E-03
ns
6.09E-01
ns
2.46E-03
ns
ns
1.07E-03
5.65E-02
2.44E-06
9.39E-01
6.19E-01
4.16E-02
ns
ns
4.12E-01
ns
ns
ns
1.89E-01
ns
4.64E-01
7.99E-06
ns
ns
ns
3.61E-01
7.06E-01
ns
1.52E-05
ns
ns
ns
4.86E-02
4.79E-01
ns
7.73E-01
7.58E-01
4.61E-01
ns
3.46E-07
1.51E-01
ns
ns
3.21E-04
ns
1.94E-01
1.64E-03
ns
5.40E-01
3.86E-05
1.65E-02
ns
3.22E-03
ns
ns
ns
5.56E-03
7.33E-01
ns
4.99E-02
ns
ns
2.67E-02
++++
-++++-?
---+
?+
-+?
--++
+?++??+
?+
?-?++
-+--+
-?
++
-??+
++
?+
?+
++
?+
-+?+
++
+-?
+-+
-?++?+?
??-++
+??++
+?
++
-?+
-+
++
+??+
+?
-+
+--?
-+
+?----++
?-+-?
--?++
++-+
-+
--?
-?
-+
+++
+-+
++++
+?
?-+
+?+
-?
?+
++
+-?+++++-?---++
+-+
-+
++
?+--++
-+
-?--+
?+
--
515
515
515
515
515
515
515
515
302
515
515
515
213
515
302
515
515
515
515
213
515
515
213
213
213
213
515
213
515
515
515
515
515
515
0
515
515
213
213
515
213
213
515
213
515
515
213
515
515
515
0
515
515
515
213
515
515
213
302
213
213
515
515
515
213
213
515
302
515
515
213
515
515
515
213
213
302
515
515
515
302
515
515
213
515
515
515
515
515
213
515
515
302
515
515
213
515
515
515
515
515
515
302
302
515
515
515
515
515
515
515
515
302
213
515
515
213
302
213
515
515
515
213
515
515
515
515
515
515
213
515
515
515
515
515
515
515
515
213
515
515
515
515
515
515
213
515
515
213
515
1.495
0.173
1.256
-2.467
-0.117
0.274
1.058
-0.871
-1.329
-1.160
-3.925
0.401
0.779
-1.276
0.313
-0.292
-2.243
0.652
-0.402
-1.949
-0.710
-0.355
-3.079
0.997
2.640
-2.420
-2.183
-0.094
1.648
-3.445
0.437
-2.191
-0.023
-4.300
ns
2.879
-1.343
-0.524
0.470
2.311
1.585
0.532
3.034
2.301
-0.876
2.349
2.174
1.208
0.159
-1.126
ns
-0.694
0.647
-1.012
-4.205
-0.126
-1.365
-0.543
1.835
-1.170
-0.617
-2.927
3.714
0.062
-1.160
-0.822
2.363
0.889
0.327
-3.536
2.370
-0.404
1.078
0.809
-0.387
0.645
1.572
0.892
0.122
-2.468
-0.858
0.357
0.319
-0.369
-1.423
-1.177
-0.844
-0.805
1.081
-0.458
-1.529
-0.090
-0.493
-1.700
-0.350
-0.812
3.685
-0.791
-0.194
-0.132
0.738
-1.911
-0.145
-1.807
0.149
0.779
1.648
0.300
-0.786
-0.004
-0.007
2.192
0.571
-2.029
0.564
-0.186
1.436
-1.825
2.185
0.672
-0.636
-0.733
-0.708
-0.298
-0.622
1.894
0.339
-1.564
-1.029
-1.398
-0.486
-0.408
-2.479
2.251
-0.872
0.236
-0.868
2.019
-1.795
-0.267
-0.604
-2.254
3.390
0.374
-1.174
-2.148
-1.461
0.823
2.112
-0.584
1.35E-01
8.63E-01
2.09E-01
1.36E-02
9.07E-01
7.84E-01
2.90E-01
3.84E-01
1.84E-01
2.46E-01
8.66E-05
6.89E-01
4.36E-01
2.02E-01
7.54E-01
7.70E-01
2.49E-02
5.15E-01
6.88E-01
5.13E-02
4.78E-01
7.23E-01
2.08E-03
3.19E-01
8.28E-03
1.55E-02
2.91E-02
9.25E-01
9.93E-02
5.71E-04
6.62E-01
2.85E-02
9.82E-01
1.71E-05
ns
3.99E-03
1.79E-01
6.00E-01
6.38E-01
2.08E-02
1.13E-01
5.95E-01
2.41E-03
2.14E-02
3.81E-01
1.88E-02
2.97E-02
2.27E-01
8.73E-01
2.60E-01
ns
4.88E-01
5.18E-01
3.12E-01
2.61E-05
9.00E-01
1.72E-01
5.87E-01
6.65E-02
2.42E-01
5.37E-01
3.42E-03
2.04E-04
9.50E-01
2.46E-01
4.11E-01
1.81E-02
3.74E-01
7.44E-01
4.06E-04
1.78E-02
6.86E-01
2.81E-01
4.19E-01
6.99E-01
5.19E-01
1.16E-01
3.72E-01
9.03E-01
1.36E-02
3.91E-01
7.21E-01
7.50E-01
7.12E-01
1.55E-01
2.39E-01
3.99E-01
4.21E-01
2.80E-01
6.47E-01
1.26E-01
9.28E-01
6.22E-01
8.92E-02
7.27E-01
4.17E-01
2.29E-04
4.29E-01
8.47E-01
8.95E-01
4.61E-01
5.60E-02
8.85E-01
7.08E-02
8.81E-01
4.36E-01
9.94E-02
7.64E-01
4.32E-01
9.97E-01
9.94E-01
2.84E-02
5.68E-01
4.25E-02
5.73E-01
8.52E-01
1.51E-01
6.80E-02
2.89E-02
5.01E-01
5.25E-01
4.63E-01
4.79E-01
7.66E-01
5.34E-01
5.82E-02
7.35E-01
1.18E-01
3.04E-01
1.62E-01
6.27E-01
6.83E-01
1.32E-02
2.44E-02
3.83E-01
8.13E-01
3.86E-01
4.35E-02
7.27E-02
7.90E-01
5.46E-01
2.42E-02
6.99E-04
7.08E-01
2.40E-01
3.17E-02
1.44E-01
4.11E-01
3.47E-02
5.59E-01
+
+
+
+
+
+
?
+
?
?
?
?
?
+
?
+
+
?
+
+
?
?
+
?
?
+
?
+
?
+
?
+
?
?
+
?
?
+
+
?
?
+
+
+
?
+
+
?
?
+
+
+
?
+
?
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
?
+
?
?
+
+
?
+
?
+
+
+
+
+
?
+
+
+
?
+
+
?
-
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
0
0
0
0
299
0
299
0
299
299
299
299
0
299
299
0
0
299
0
0
299
0
299
299
0
299
299
299
0
299
299
299
0
299
299
0
299
0
0
299
299
299
0
0
299
299
299
299
0
299
299
299
0
0
299
299
299
299
299
299
299
0
299
299
299
299
299
0
299
299
299
299
299
0
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
299
0
299
299
0
299
0
299
299
299
0
299
299
299
299
299
299
0
299
299
299
299
299
299
299
299
0
299
299
299
299
299
299
0
299
299
0
299
-0.004
0.004
-0.009
-0.005
-0.007
0.004
0.015
-0.009
-0.031
-0.015
-0.051
-0.006
0.006
-0.003
0.007
-0.004
-0.008
0.004
-0.008
ns
0.015
-0.015
ns
ns
ns
ns
-0.028
ns
0.003
ns
0.001
-0.005
0.016
-0.042
ns
0.020
0.005
ns
ns
0.016
ns
ns
0.016
ns
-0.011
0.015
ns
0.009
-0.008
-0.016
ns
-0.010
0.002
-0.001
ns
-0.005
-0.009
ns
0.023
ns
ns
-0.008
0.019
0.004
ns
ns
0.008
0.001
0.014
-0.017
ns
0.009
0.021
-0.004
ns
ns
0.007
0.001
-0.003
0.001
-0.002
-0.019
-0.009
ns
-0.006
-0.002
-0.017
-0.006
0.012
ns
-0.006
0.011
0.000
-0.016
0.015
ns
0.022
-0.005
0.002
0.000
0.004
-0.028
0.000
-0.002
0.002
-0.004
0.008
0.001
0.002
0.020
0.024
0.021
-0.010
ns
0.004
-0.005
ns
-0.009
ns
0.015
0.012
-0.017
ns
-0.008
-0.017
-0.007
-0.007
0.022
-0.004
ns
0.010
0.004
-0.004
0.011
-0.003
0.010
-0.009
0.004
ns
0.002
0.001
-0.004
0.003
-0.002
-0.007
ns
0.002
0.019
ns
-0.021
0.007
0.008
0.004
0.003
0.005
0.003
0.007
0.003
0.006
0.005
0.009
0.005
0.002
0.005
0.005
0.003
0.005
0.003
0.006
ns
0.007
0.004
ns
ns
ns
ns
0.006
ns
0.005
ns
0.004
0.006
0.005
0.005
ns
0.005
0.003
ns
ns
0.008
ns
ns
0.005
ns
0.008
0.005
ns
0.004
0.004
0.007
ns
0.005
0.002
0.009
ns
0.007
0.007
ns
0.006
ns
ns
0.003
0.006
0.002
ns
ns
0.003
0.005
0.006
0.004
ns
0.003
0.005
0.002
ns
ns
0.005
0.002
0.002
0.002
0.003
0.008
0.004
ns
0.005
0.003
0.006
0.002
0.006
ns
0.004
0.005
0.002
0.007
0.008
ns
0.006
0.005
0.004
0.005
0.002
0.009
0.004
0.002
0.002
0.003
0.005
0.002
0.003
0.007
0.008
0.006
0.006
ns
0.002
0.004
ns
0.005
ns
0.007
0.006
0.006
ns
0.004
0.005
0.004
0.004
0.014
0.002
ns
0.004
0.002
0.003
0.005
0.003
0.004
0.004
0.003
ns
0.004
0.003
0.002
0.003
0.004
0.003
ns
0.003
0.008
ns
0.006
5.88E-01
5.61E-01
2.89E-02
1.79E-01
2.02E-01
1.71E-01
4.12E-02
9.07E-03
1.03E-07
4.67E-03
6.49E-08
2.67E-01
2.15E-03
4.44E-01
2.03E-01
2.16E-01
8.41E-02
2.58E-01
2.31E-01
ns
2.72E-02
1.80E-04
ns
ns
ns
ns
2.47E-06
ns
5.00E-01
ns
8.91E-01
3.79E-01
7.40E-04
1.04E-13
ns
1.66E-05
1.11E-01
ns
ns
4.75E-02
ns
ns
1.21E-03
ns
1.44E-01
3.57E-03
ns
3.58E-02
3.28E-02
2.26E-02
ns
3.88E-02
5.32E-01
9.56E-01
ns
4.09E-01
2.37E-01
ns
7.41E-05
ns
ns
2.39E-03
1.78E-03
1.07E-01
ns
ns
3.67E-03
8.42E-01
1.48E-02
1.69E-04
ns
1.19E-02
6.93E-06
1.42E-01
ns
ns
1.72E-01
5.66E-01
2.47E-01
5.31E-01
5.49E-01
1.62E-02
3.60E-02
ns
2.02E-01
5.93E-01
9.00E-03
5.46E-03
6.70E-02
ns
1.52E-01
2.03E-02
9.91E-01
2.66E-02
5.91E-02
ns
1.74E-04
2.89E-01
6.17E-01
9.61E-01
6.20E-02
1.58E-03
9.26E-01
3.20E-01
3.67E-01
1.89E-01
9.98E-02
5.13E-01
3.93E-01
3.89E-03
4.24E-03
9.02E-04
1.13E-01
ns
4.36E-02
1.73E-01
ns
9.39E-02
ns
2.54E-02
3.70E-02
8.99E-03
ns
2.47E-02
1.60E-03
4.12E-02
5.40E-02
1.10E-01
1.04E-01
ns
6.48E-03
1.05E-01
2.14E-01
3.64E-02
2.75E-01
2.00E-02
2.52E-02
8.00E-02
ns
5.81E-01
7.55E-01
4.11E-02
3.51E-01
5.70E-01
9.56E-03
ns
6.17E-01
1.77E-02
ns
2.26E-04
+++---+
++
-?--+
-+
++
++
?+
-+
--?
---+
--+
+-+
--+
-+
-+
-+
--?
-+
++
?+
++
++
-++
++
++
++
++?
-+
-++
+-+
-?+
-+++
--+
--?
?+
--+++
-+
---+
?++
-+?
-+
-+
+-+
-?
?--++
?+
++
---+
--+
-?
++
-+
-+?
+-+
-+
++
--+
-+
+-?+
?
-++
++
--+
++
--+
?-+
++
-?
+?++
-+
-+
-+
---+?
-+
-+
----?
-++
--++
++
--+
+?
-+
+++
---+
++
++
--
567
567
567
567
567
567
567
567
354
567
567
567
567
567
354
567
567
213
567
567
567
567
567
567
567
567
567
567
567
567
567
213
567
567
354
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
354
567
567
567
567
567
567
213
354
567
567
567
567
567
567
567
567
354
567
567
213
567
567
567
567
213
354
567
567
567
354
567
567
567
567
567
567
213
567
567
567
567
0
567
567
567
567
567
567
567
567
567
354
0
567
567
567
567
567
567
567
567
354
567
567
213
567
354
567
567
567
567
567
567
567
213
567
567
567
567
567
213
567
567
567
567
567
567
567
567
213
567
567
567
567
567
567
567
567
567
0.257
-1.663
0.609
-3.572
-2.052
-0.262
3.219
-1.605
-1.787
-2.354
1.215
2.059
1.720
3.305
1.514
0.230
-2.666
-1.766
-0.895
-1.022
1.072
-3.198
-0.662
0.212
0.425
-1.538
1.607
1.718
1.340
0.721
-3.192
-2.694
1.930
2.766
0.059
3.289
2.330
-3.583
2.990
1.942
1.617
3.402
0.333
0.319
-1.367
-1.666
2.027
-2.202
0.825
-3.000
0.415
-1.750
0.106
2.673
-1.040
-0.526
-4.605
-0.820
4.582
-1.312
-2.432
-0.752
3.453
-0.153
-1.384
-2.605
-0.737
-1.049
1.407
-1.240
2.158
0.691
1.722
-1.359
-0.228
-1.094
-3.680
-0.330
-0.990
0.951
1.898
1.923
-2.477
-2.370
-0.521
-1.902
-0.937
-0.432
1.560
0.050
-1.101
0.533
ns
-2.504
0.950
2.505
1.090
-1.860
-0.708
1.809
0.298
-1.803
2.026
ns
-2.645
1.288
1.848
-1.362
-0.008
3.023
-0.116
-1.412
-3.377
-0.835
3.377
-1.678
0.193
-1.332
1.334
0.452
1.509
1.834
-3.312
-2.442
-5.016
0.376
-0.040
2.492
-2.456
-2.370
-0.982
-0.194
-3.063
1.629
-0.336
-1.423
4.744
1.445
-0.671
0.390
0.240
-0.569
-0.119
1.214
-3.173
-2.629
3.094
3.693
3.844
-1.373
7.97E-01
9.62E-02
5.42E-01
3.55E-04
4.01E-02
7.94E-01
1.29E-03
1.08E-01
7.39E-02
1.86E-02
2.25E-01
3.95E-02
8.54E-02
9.51E-04
1.30E-01
8.18E-01
7.68E-03
7.74E-02
3.71E-01
3.07E-01
2.84E-01
1.38E-03
5.08E-01
8.32E-01
6.71E-01
1.24E-01
1.08E-01
8.58E-02
1.80E-01
4.71E-01
1.42E-03
7.05E-03
5.36E-02
5.68E-03
9.53E-01
1.00E-03
1.98E-02
3.40E-04
2.79E-03
5.21E-02
1.06E-01
6.68E-04
7.39E-01
7.50E-01
1.72E-01
9.57E-02
4.26E-02
2.76E-02
4.09E-01
2.70E-03
6.78E-01
8.01E-02
9.15E-01
7.52E-03
2.98E-01
5.99E-01
4.13E-06
4.12E-01
4.61E-06
1.90E-01
1.50E-02
4.52E-01
5.54E-04
8.79E-01
1.66E-01
9.18E-03
4.61E-01
2.94E-01
1.59E-01
2.15E-01
3.09E-02
4.89E-01
8.51E-02
1.74E-01
8.19E-01
2.74E-01
2.33E-04
7.42E-01
3.22E-01
3.42E-01
5.77E-02
5.45E-02
1.33E-02
1.78E-02
6.03E-01
5.71E-02
3.49E-01
6.66E-01
1.19E-01
9.60E-01
2.71E-01
5.94E-01
ns
1.23E-02
3.42E-01
1.22E-02
2.76E-01
6.28E-02
4.79E-01
7.05E-02
7.66E-01
7.13E-02
4.28E-02
ns
8.16E-03
1.98E-01
6.46E-02
1.73E-01
9.93E-01
2.50E-03
9.08E-01
1.58E-01
7.34E-04
4.04E-01
7.32E-04
9.33E-02
8.47E-01
1.83E-01
1.82E-01
6.52E-01
1.31E-01
6.67E-02
9.28E-04
1.46E-02
5.28E-07
7.07E-01
9.68E-01
1.27E-02
1.41E-02
1.78E-02
3.26E-01
8.46E-01
2.19E-03
1.03E-01
7.37E-01
1.55E-01
2.10E-06
1.48E-01
5.02E-01
6.96E-01
8.10E-01
5.69E-01
9.06E-01
2.25E-01
1.51E-03
8.57E-03
1.98E-03
2.22E-04
1.21E-04
1.70E-01
+
?
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
?
+
+
?
+
+
+
+
+
+
+
+
+
+
+
?
+
+
+
+
?
?
+
+
?
+
+
?
+
+
+
+
+
+
?
?
+
+
+
+
?
+
+
+
+
+
?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
869
869
0
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
0
869
0
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
0
0
869
869
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
0
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
869
0.002
-0.007
ns
0.002
0.004
0.000
-0.003
-0.003
ns
-0.002
0.002
0.004
0.001
0.002
0.003
-0.002
-0.001
-0.008
0.002
-0.002
0.001
0.002
0.001
-0.001
0.001
0.005
-0.001
-0.001
-0.003
-0.003
-0.002
0.004
0.000
ns
0.000
0.001
-0.008
0.004
ns
0.001
-0.002
0.002
0.002
-0.003
0.004
0.002
0.001
0.000
-0.001
0.000
0.001
0.002
0.000
0.003
0.000
0.001
ns
0.003
0.001
-0.003
0.001
-0.001
0.000
-0.002
-0.002
ns
-0.003
ns
0.000
0.003
-0.005
ns
-0.002
0.001
0.000
0.000
0.002
-0.005
-0.001
-0.001
ns
0.000
0.003
-0.001
0.002
0.000
0.000
0.001
-0.001
0.004
0.002
ns
ns
-0.001
-0.002
0.001
0.002
0.005
0.000
-0.002
0.000
0.000
0.000
ns
0.000
0.004
0.001
0.004
-0.001
0.001
-0.001
-0.001
ns
0.003
0.000
0.004
0.006
0.001
-0.002
-0.005
-0.005
-0.003
0.003
0.004
-0.002
0.000
-0.006
-0.001
-0.002
0.000
-0.004
0.004
0.005
0.003
0.004
0.005
0.001
-0.001
0.003
-0.001
-0.002
0.000
0.003
0.002
0.001
0.001
0.000
-0.005
0.001
0.003
0.000
0.003
ns
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.002
0.001
0.002
0.001
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.002
0.001
0.001
0.002
0.003
0.001
0.001
0.001
ns
0.001
0.001
0.002
0.001
ns
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.003
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
ns
0.001
0.001
0.002
ns
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.000
ns
0.000
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
ns
ns
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
ns
0.001
0.000
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.000
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
0.001
0.001
0.001
0.001
0.002
0.001
0.001
7.84E-04
4.33E-02
ns
2.46E-01
2.37E-03
6.01E-01
1.53E-02
1.75E-02
ns
1.28E-01
4.28E-01
4.46E-05
5.87E-01
1.31E-03
2.97E-02
9.96E-02
2.72E-01
5.61E-03
5.06E-02
5.72E-02
2.67E-01
2.44E-02
7.55E-01
4.13E-02
2.04E-01
2.07E-03
3.02E-01
5.64E-01
5.29E-02
2.47E-01
8.44E-02
1.59E-03
6.12E-01
ns
6.42E-01
5.39E-01
1.55E-04
9.01E-03
ns
2.17E-01
8.51E-02
6.02E-02
1.96E-03
1.87E-01
1.92E-04
2.57E-02
7.35E-02
5.93E-01
3.45E-01
9.13E-01
7.72E-01
1.63E-01
9.25E-01
1.30E-03
7.91E-01
1.46E-01
ns
4.80E-03
1.73E-01
1.47E-02
4.86E-01
4.25E-01
9.79E-01
1.92E-01
9.67E-02
ns
7.19E-04
ns
7.77E-01
5.31E-03
1.82E-03
ns
6.73E-02
9.41E-02
6.32E-01
7.57E-01
3.28E-02
4.84E-04
6.56E-01
1.61E-01
ns
3.54E-01
9.62E-03
5.33E-01
3.32E-02
8.45E-01
6.30E-01
5.03E-01
2.91E-01
9.09E-03
3.21E-02
ns
ns
2.58E-01
2.97E-01
5.16E-01
6.05E-04
8.39E-04
9.31E-01
4.05E-02
8.61E-01
7.10E-01
6.90E-01
ns
9.93E-01
5.20E-05
4.71E-01
1.95E-04
4.79E-01
2.50E-02
1.34E-01
2.11E-01
ns
3.56E-04
7.52E-01
3.29E-03
1.85E-08
3.40E-01
1.41E-01
1.44E-03
5.80E-05
1.27E-02
3.49E-03
3.06E-03
1.72E-02
9.29E-01
1.12E-04
6.86E-01
1.07E-01
8.29E-01
3.13E-04
2.10E-05
6.48E-04
1.13E-03
5.46E-04
4.31E-07
2.40E-01
4.92E-01
1.07E-02
9.20E-02
4.66E-01
9.18E-01
9.91E-03
5.15E-03
2.82E-01
3.96E-01
8.33E-01
2.15E-02
2.68E-01
7.25E-03
+
?
?
?
?
?
?
?
?
?
+
?
?
?
+
+
+
+
?
?
?
?
+
?
?
+
?
?
+
+
?
?
?
+
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
+
+
?
?
?
?
?
?
+
+
?
?
+
?
?
?
+
?
?
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
?
?
?
?
+
?
?
?
?
?
+
+
?
?
?
+
?
?
?
?
?
?
?
?
?
-
1244
1244
1244
0
0
0
0
1244
0
1244
0
0
0
0
1244
0
0
0
1244
1244
1244
1244
1244
1244
1244
0
1244
0
0
0
1244
0
0
1244
1244
0
0
1244
1244
1244
0
0
0
1244
0
0
0
1244
1244
0
0
1244
0
0
0
1244
1244
0
0
0
0
1244
0
0
1244
0
1244
1244
0
0
0
0
0
1244
1244
1244
1244
1244
1244
1244
1244
0
1244
0
0
1244
0
0
0
1244
1244
1244
0
0
1244
0
0
0
1244
0
0
0
0
0
0
0
0
1244
0
0
0
1244
0
1244
0
0
0
1244
0
0
0
1244
0
0
1244
1244
0
0
1244
0
0
0
1244
1244
1244
1244
0
0
0
1244
0
0
0
0
0
0
0
0
0
1244
0.001
-0.001
0.000
ns
ns
ns
ns
0.000
ns
-0.003
ns
ns
ns
ns
0.000
ns
ns
ns
0.001
-0.001
-0.001
-0.002
0.001
0.002
0.001
ns
-0.002
ns
ns
ns
0.001
ns
ns
-0.003
0.000
ns
ns
0.000
0.001
0.006
ns
ns
ns
0.001
ns
ns
ns
0.002
0.000
ns
ns
-0.002
ns
ns
ns
0.000
-0.001
ns
ns
ns
ns
-0.001
ns
ns
-0.003
ns
0.001
-0.001
ns
ns
ns
ns
ns
-0.001
-0.001
-0.001
0.002
-0.001
-0.001
0.000
-0.001
ns
-0.001
ns
ns
0.000
ns
ns
ns
0.000
0.000
0.000
ns
ns
0.000
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
0.000
ns
ns
ns
0.001
ns
0.000
ns
ns
ns
0.000
ns
ns
ns
-0.001
ns
ns
-0.003
0.000
ns
ns
0.000
ns
ns
ns
-0.001
0.003
0.000
0.002
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.000
0.001
0.001
0.000
ns
ns
ns
ns
0.000
ns
0.001
ns
ns
ns
ns
0.001
ns
ns
ns
0.000
0.000
0.001
0.001
0.001
0.000
0.000
ns
0.001
ns
ns
ns
0.000
ns
ns
0.000
0.000
ns
ns
0.000
0.000
0.001
ns
ns
ns
0.001
ns
ns
ns
0.000
0.000
ns
ns
0.000
ns
ns
ns
0.000
0.001
ns
ns
ns
ns
0.000
ns
ns
0.000
ns
0.000
0.001
ns
ns
ns
ns
ns
0.000
0.000
0.000
0.000
0.000
0.000
0.000
0.000
ns
0.000
ns
ns
0.000
ns
ns
ns
0.000
0.000
0.000
ns
ns
0.001
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
0.000
ns
ns
ns
0.000
ns
0.000
ns
ns
ns
0.000
ns
ns
ns
0.000
ns
ns
0.001
0.000
ns
ns
0.000
ns
ns
ns
0.000
0.001
0.000
0.000
ns
ns
ns
0.000
ns
ns
ns
ns
ns
ns
ns
ns
ns
0.000
9.80E-02
1.93E-01
3.91E-02
ns
ns
ns
ns
7.33E-01
ns
1.86E-07
ns
ns
ns
ns
8.62E-01
ns
ns
ns
2.31E-01
3.51E-05
2.04E-01
2.86E-06
4.96E-02
1.31E-05
6.01E-02
ns
6.11E-06
ns
ns
ns
8.63E-03
ns
ns
2.40E-18
3.76E-01
ns
ns
7.70E-01
6.16E-02
5.34E-09
ns
ns
ns
7.29E-02
ns
ns
ns
2.18E-10
3.65E-01
ns
ns
1.50E-04
ns
ns
ns
1.53E-01
9.66E-02
ns
ns
ns
ns
8.52E-05
ns
ns
1.36E-11
ns
3.56E-02
3.50E-01
ns
ns
ns
ns
ns
1.78E-02
1.71E-01
6.08E-04
4.51E-09
7.29E-02
4.94E-05
5.79E-01
3.18E-06
ns
3.06E-03
ns
ns
5.73E-03
ns
ns
ns
1.65E-01
3.44E-01
2.07E-01
ns
ns
8.07E-01
ns
ns
ns
1.40E-01
ns
ns
ns
ns
ns
ns
ns
ns
9.16E-02
ns
ns
ns
2.95E-04
ns
8.03E-01
ns
ns
ns
9.88E-01
ns
ns
ns
4.21E-03
ns
ns
2.01E-04
9.88E-01
ns
ns
1.73E-02
ns
ns
ns
6.32E-05
1.15E-05
8.93E-02
1.27E-05
ns
ns
ns
8.33E-01
ns
ns
ns
ns
ns
ns
ns
ns
ns
8.61E-01
-+-?
--+
++
++-?
-+
--+?
-+++
++--+-+
++?
+--+
-++
-+
++
-+
++
+-?
+++
-+
++
++
++
+++
+-+
++
-++
-+
--?
-++
++
+-+
-+
-?
++
++
--?
++
++-+
++
-?
++
++
++
-?
++
+-+?
++
+-+-?
+?
--+
++
-+
-+?
++
++
-+?
-?
-+
+++
+-+
+-++
-++
-?
++
-+
-+
+++
+++-?
++
+-+-+
++
-+
++
----+
-++
+-+
-+
++
+?
-+
++
-+
++
-+
++
+?
-+?
+++
++
+-++--+
362
362
134
362
362
362
362
362
134
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
134
362
362
362
134
362
362
362
362
362
134
362
362
362
134
362
362
362
134
362
362
362
362
134
134
362
362
362
362
362
134
362
362
362
134
134
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
362
134
362
362
362
362
362
362
134
362
134
362
362
362
362
362
362
362
362
362
-1.502
0.036
-2.715
-2.995
0.099
0.395
-0.160
-1.009
-1.742
-0.835
-2.180
-1.762
0.455
-1.437
-1.427
0.393
-1.003
-0.165
-1.995
-3.678
-1.863
1.165
-0.303
0.078
-1.156
-0.805
-1.684
-1.477
1.952
0.465
0.049
-0.214
0.671
-1.234
-1.526
-0.874
1.107
0.547
0.822
1.582
1.367
-1.006
1.447
-0.669
0.509
1.411
-0.635
2.024
0.287
-2.065
-0.937
-0.960
1.998
1.006
-0.443
0.097
0.790
-1.388
1.706
1.584
-1.793
-1.852
2.463
-0.480
-1.516
1.164
0.904
-2.071
0.499
0.632
1.059
-1.198
0.718
0.125
-0.884
0.388
1.247
-1.160
-0.750
-0.419
-1.800
0.197
-2.346
-0.158
0.257
-1.019
-2.689
0.643
0.854
0.852
-1.037
0.014
-0.968
0.138
0.027
0.566
-0.536
0.616
-0.542
-1.703
0.964
-3.208
0.982
-0.705
0.739
0.202
0.277
-0.550
0.365
-1.789
-0.198
-0.388
-1.708
1.009
-0.517
-1.251
-0.139
1.006
2.297
0.657
2.329
-2.369
-1.618
-2.552
0.361
-1.627
1.794
-0.323
1.097
-1.389
0.552
0.113
-0.119
1.258
-0.879
0.537
1.913
1.604
0.201
-1.530
0.025
-0.095
0.880
0.452
-0.608
-3.198
-0.153
-0.331
-1.303
-0.213
1.33E-01
9.71E-01
6.62E-03
2.74E-03
9.21E-01
6.93E-01
8.73E-01
3.13E-01
8.15E-02
4.04E-01
2.92E-02
7.81E-02
6.49E-01
1.51E-01
1.54E-01
6.94E-01
3.16E-01
8.69E-01
4.60E-02
2.35E-04
6.24E-02
2.44E-01
7.62E-01
9.38E-01
2.48E-01
4.21E-01
9.22E-02
1.40E-01
5.10E-02
6.42E-01
9.61E-01
8.30E-01
5.02E-01
2.17E-01
1.27E-01
3.82E-01
2.68E-01
5.84E-01
4.11E-01
1.14E-01
1.72E-01
3.14E-01
1.48E-01
5.03E-01
6.11E-01
1.58E-01
5.25E-01
4.29E-02
7.74E-01
3.90E-02
3.49E-01
3.37E-01
4.57E-02
3.14E-01
6.58E-01
9.23E-01
4.30E-01
1.65E-01
8.81E-02
1.13E-01
7.30E-02
6.40E-02
1.38E-02
6.31E-01
1.30E-01
2.44E-01
3.66E-01
3.84E-02
6.18E-01
5.27E-01
2.90E-01
2.31E-01
4.73E-01
9.01E-01
3.77E-01
6.98E-01
2.13E-01
2.46E-01
4.54E-01
6.75E-01
7.18E-02
8.44E-01
1.90E-02
8.75E-01
7.97E-01
3.08E-01
7.16E-03
5.20E-01
3.93E-01
3.94E-01
3.00E-01
9.89E-01
3.33E-01
8.91E-01
9.79E-01
5.71E-01
5.92E-01
5.38E-01
5.88E-01
8.86E-02
3.35E-01
1.34E-03
3.26E-01
4.81E-01
4.60E-01
8.40E-01
7.82E-01
5.82E-01
7.15E-01
7.37E-02
8.43E-01
6.98E-01
8.77E-02
3.13E-01
6.05E-01
2.11E-01
8.89E-01
3.14E-01
2.16E-02
5.11E-01
1.99E-02
1.79E-02
1.06E-01
1.07E-02
7.18E-01
1.04E-01
7.28E-02
7.47E-01
2.73E-01
1.65E-01
5.81E-01
9.10E-01
9.05E-01
2.08E-01
3.80E-01
5.91E-01
5.57E-02
1.09E-01
8.41E-01
1.26E-01
9.80E-01
9.25E-01
3.79E-01
6.51E-01
5.43E-01
1.39E-03
8.79E-01
7.41E-01
1.93E-01
8.31E-01
42378
46596
18974
54249
65945
47070
496
26669
26457
19122
42096
26175
13876
48196
20927
27430
19815
11320
42719
1865
67731
1011
8862
19172
31295
5047
31733
51708
9803
65643
17281
35800
37665
9718
29099
19316
47803
52545
37366
712
50678
23883
2118
18030
17235
68240
55405
5016
65558
20304
42964
60984
12685
26105
39088
34936
13840
27947
62767
65679
35411
54616
46934
40498
22643
24904
8538
42849
45933
54788
12786
37745
15902
20255
41657
21352
55020
15063
33345
54675
37966
62292
7940
29199
61709
64813
8757
48059
1755
37427
40368
4900
11715
12081
59729
20577
26170
20220
40577
65282
14448
44264
50592
45821
59292
52444
43100
33533
5621
39916
59299
56078
47238
61481
44979
26057
63844
55325
40147
7860
68516
11459
4271
56270
18563
19582
20668
49239
40530
52324
56215
55535
39414
41487
28814
23992
67638
43681
13707
25050
59137
22526
21484
9446
19919
46679
20149
20530
54277
12111
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
125488
959
23348
10981
9050
80342
4306
56907
29979
163882
23261
89872
7316
284018
6504
917
1434
57085
2204
127943
54908
5413
10867
3568
58472
432
6230
3693
162394
9256
54438
6280
79746
9605
51313
6037
55665
25942
9517
152926
8556
79772
8992
713
10398
2339
84282
7095
26065
26019
8029
201191
11033
330
10207
6627
255488
7163
60487
27314
8797
10782
3419
8883
4929
27018
57489
56940
387129
340547
57325
171425
1880
2161
23190
2815
8993
9054
51106
284406
84671
5013
56650
4820
79091
90799
5074
55174
8819
221
6328
3779
6368
1071
1774
3337
1615
9521
54847
923
3690
23014
157638
22927
2675
1475
2201
2994
55795
1843
5984
5055
2896
968
2034
7450
9585
122416
55884
91801
55778
834
54994
338339
5583
2878
80346
79632
10892
23731
55859
80824
55969
90624
545
7030
25953
117177
9737
8751
91298
5504
79848
4088
622
945
54897
7574
57616
117145
TTC39C
CD40LG
DOCK9
RAB32
PSTPIP2
TRAF3IP3
NR3C2
SPIRE1
UBQLN1
CNST
CAMTA1
AQP10
UBC
C17orf58
SLAMF1
CD3G
CSE1L
AGTRAP
FCAR
FCRLB
SPDL1
SEPT5
TSPAN9
IL5RA
SQRDL
ASGR1
RPS25
ITGB5
SLFN5
BZRAP1
GFOD1
S100A9
ECHDC3
VPS9D1
FAM198B
RNASE3
URGCP
SIN3A
SPTLC2
PPM1K
CDC14A
MCTP1
ATP6V0E1
C1QB
MYL9
FNTA
RNF135
SEC62
LSM14A
UPF2
CUBN
SAMD14
ADAP1
BIRC3
INADL
SNRPA1
RNF144B
TPD52
TRMT11
RAB30
TNFRSF10A
ZNF274
IDH3A
NAE1
NR4A2
NGFRAP1
ODF2L
DUSP22
NPSR1
VSIG1
CSRP2BP
CLYBL
GPR183
F12
UBXN4
GP9
PGLYRP1
NFS1
TFB1M
ZFP82
ZNF347
OTX1
CLDND1
NKTR
METTL22
CEP95
PAWR
INTS10
SAP30
ALDH3B1
SCN3A
KCNMB1
CCL23
CETP
DNASE1L1
DNAJB1
DARS
EEF1E1
SIDT1
CD6
ITGB3
FBXO21
FAM84B
HABP4
GFRA2
CSTA
FBN2
GYPB
PCID2
DUSP1
RFC4
SERPINB2
GRN
CD68
EPAS1
VWF
KIF20B
ANKRD9
WSB2
ALKBH8
ZNF839
CASP1
GID8
CLEC4D
PRKCH
GPX3
REEP4
FAM184A
MALT1
TMEM245
BEX1
DUSP16
C20orf24
LYRM7
ATR
TFE3
PNKD
RAB3IP
GPRASP1
ADAM15
C12orf29
PPP1R2
CSPP1
SMAD3
BDH1
CD33
CASZ1
ZNF26
TSHZ3
THEM4
-------------?-++++++
++++++
----------++++++
---------------++++++
++++++
+-++++
---------------++++++
++++++
++++++
-----++-+++
++++++
++++++
++++++
++++++
-----++-+++
-----++++++
++++++
++++++
-+++++
++++++
++++++
++++++
----------++++++
----------++++++
++++++
++++++
++++++
-----++++++
------------+-------++++++
++++++
+---++-------?-++++++
-----------------------------------++++++
----------++++++
++--++
---------------+---+++++++
-----++-+++
++++++
++-++-----------+---++++++
-----+----++++++
---------------++++++
++++++
-++--+++?++
++++++
++++++
++++++
-------------------------+++++--------------+++++++
++++++
++++++
----------+-++-+
-----++++++
++++++
++++++
++++++
++-+++
----+++++++
+-++++
---+------++++++
-----++++++
-----++++++
++++++
---------------++++++
+-+--++++++
--+-------++++++
++++++
------+---++++++
---------------+---------++++-+
++-+++
-----++++++
----+-
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-11.301
-10.314
-10.086
10.06
9.573
-9.501
-9.054
9.033
-8.867
-8.837
-8.604
8.59
8.571
8.547
-8.51
-8.504
-8.391
8.368
8.283
8.239
-8.096
8.094
8.087
8.007
7.989
7.952
-7.889
7.852
-7.834
7.759
7.695
7.661
7.618
7.564
7.56
7.554
-7.522
-7.493
7.493
-7.479
-7.47
7.399
7.367
7.325
7.308
-7.301
7.254
-7.223
-7.22
-7.193
-7.188
7.168
7.165
-7.146
-7.143
-7.141
7.128
-7.093
-7.089
-7.077
-7.055
-7.037
-7.02
-7.02
7.013
-7.009
-6.954
6.947
6.938
-6.935
-6.928
-6.924
-6.923
6.919
-6.913
6.884
6.877
6.877
-6.866
-6.849
-6.804
6.802
-6.798
-6.795
6.794
-6.776
-6.766
-6.756
6.75
6.739
-6.737
6.73
6.728
6.718
6.717
-6.707
-6.707
-6.704
-6.69
-6.682
6.681
-6.68
-6.675
-6.668
6.666
6.663
6.659
-6.656
-6.64
6.639
-6.636
6.631
6.625
6.613
6.613
6.59
-6.56
6.542
6.537
-6.536
-6.531
6.53
-6.527
6.516
-6.515
6.514
6.507
-6.503
-6.496
-6.492
6.482
-6.477
6.469
-6.463
-6.459
6.451
6.45
-6.436
-6.429
6.426
-6.426
-6.413
-6.41
-6.408
-6.395
6.386
6.377
-6.372
6.372
-6.361
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.30E-29
6.10E-25
6.35E-24
8.34E-24
1.04E-21
2.09E-21
1.37E-19
1.67E-19
7.54E-19
9.86E-19
7.69E-18
8.70E-18
1.02E-17
1.26E-17
1.73E-17
1.84E-17
4.84E-17
5.87E-17
1.21E-16
1.73E-16
5.67E-16
5.79E-16
6.12E-16
1.18E-15
1.36E-15
1.84E-15
3.04E-15
4.10E-15
4.74E-15
8.56E-15
1.42E-14
1.85E-14
2.58E-14
3.90E-14
4.04E-14
4.22E-14
5.40E-14
6.71E-14
6.72E-14
7.50E-14
8.04E-14
1.37E-13
1.75E-13
2.39E-13
2.71E-13
2.85E-13
4.04E-13
5.09E-13
5.20E-13
6.33E-13
6.55E-13
7.59E-13
7.80E-13
8.97E-13
9.16E-13
9.28E-13
1.02E-12
1.31E-12
1.35E-12
1.47E-12
1.73E-12
1.97E-12
2.21E-12
2.23E-12
2.34E-12
2.40E-12
3.56E-12
3.72E-12
3.97E-12
4.05E-12
4.26E-12
4.38E-12
4.43E-12
4.56E-12
4.75E-12
5.83E-12
6.10E-12
6.11E-12
6.61E-12
7.43E-12
1.02E-11
1.03E-11
1.06E-11
1.09E-11
1.09E-11
1.23E-11
1.32E-11
1.42E-11
1.48E-11
1.59E-11
1.62E-11
1.69E-11
1.72E-11
1.84E-11
1.86E-11
1.99E-11
1.99E-11
2.03E-11
2.23E-11
2.36E-11
2.38E-11
2.39E-11
2.47E-11
2.59E-11
2.63E-11
2.69E-11
2.75E-11
2.82E-11
3.13E-11
3.16E-11
3.22E-11
3.33E-11
3.48E-11
3.76E-11
3.77E-11
4.40E-11
5.39E-11
6.07E-11
6.27E-11
6.30E-11
6.52E-11
6.57E-11
6.70E-11
7.23E-11
7.26E-11
7.30E-11
7.64E-11
7.89E-11
8.23E-11
8.48E-11
9.06E-11
9.35E-11
9.89E-11
1.03E-10
1.05E-10
1.11E-10
1.12E-10
1.22E-10
1.29E-10
1.31E-10
1.31E-10
1.43E-10
1.46E-10
1.48E-10
1.61E-10
1.70E-10
1.81E-10
1.87E-10
1.87E-10
2.01E-10
---+---+
---+---+
+----??+++++--+
+-+++++-----+-+
+--+---++++++++
---+---+
-+---+-+
+--+--+-+++++++
++++++++++-++++
-+-+---+
----++----+---++++++++
-++-++-+
++++++++
--+--??-+++++-?
-+++++++
--+++-++
++++++-+
+-+++-++
---+----+++++-+
-+--++++++-++++
-++++++++++++-+
+-++++-+
++++++++++++--+
+++++++-------+
-----+-+
-+++-+-+
-----+++
-------++++++-+
+-+++-++
+++-++++
-+++++-+
--+----+
+++-++-+
----+--+
--+++-----------+---?--++++-+
+++-++++
++-+--++-----+-------++++++-+
-+-+---+-------+--------++--+
-----+-+
----+-+-+------++--+-+
-----+---+--+--+++++++
+++-+??+--?--?-+--------+---+
+--+--++-+++-+-++----+
-++++--+
+++-+--+
+++-+??+
------+-------+
--+--???++?+??+
+--+--------+-+
+++++-++
------+---+-?+---+-+-+-+++--+
++++++++
+-+++-++-++++++
-++?+??+++++--+
++++++-+
-+-+-+-+
-------+
--+---------+-+
-+-+-+++
-+++++++
-----+-+
+--+---++-+--+++++--++
+++++--+
+++-+-++
+--++??-+-----+-+-++-+
-+---+--+-++-++
+-+++-++
-++++-++
-++++??+
-+++++-+
+-+---+++-++-+---++--+
++--++?-------++++-++---+---+
+++++--+
-+---+-+
++++++-+
-+++++++
------+----------+---+
?+++-??+
++----++++++++----+--?--+-??++++++++
?++++??-+--++---++?-++++++++---+------+---+
------+---+--+-----??+++-++++
-++-++++
------++++-++++---+-?-
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
4829
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
6193
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
6325
5004
8009
8009
8009
8009
7782
8009
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
5363
8009
5363
8009
7888
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
6552
-3.497
-3.229
-3.426
3.97
2.535
-4.107
-4.11
3.873
-1.669
-3.426
-2.709
3.231
3.263
3.592
-2.729
-2.685
-3.597
3.701
3.214
4.231
-3.474
0.146
3.096
3.144
3.052
3.576
-4.221
3.93
-1.752
3.094
1.665
3.059
2.156
4.076
2.93
2.657
-3.965
-3.886
3.08
-1.805
-3.959
4.161
3.35
3.068
3.654
-2.798
3.487
-3.075
-2.372
-3.877
-2.748
0.442
3.778
-2.001
-0.556
-3.531
3.638
-3.218
-3.085
-4.199
-2.441
-4.091
-3.41
-4.142
3.292
-3.23
-2.322
4.03
1.959
-2.965
-3.649
-2.56
-2.125
1.699
-1.286
1.524
2.059
2.923
-3.579
-3.785
-4.028
3.2
-1.929
-1.361
3.277
-3.15
-2.999
-3.85
2.223
3.849
-3.91
4.114
0.77
1.615
3.446
-3.642
-3.488
-3.256
-3.089
-2.85
4.216
-2.147
-3.095
-2.132
2.985
3.268
4.03
-1.736
-3.565
3.721
-2.489
0.939
2.158
3.132
2.935
2.748
-2.348
1.349
1.892
-1.877
-3.343
4.081
-3.568
3.089
-3.134
3.716
4.13
-4.159
-3.623
-3.524
3.366
-1.703
2.798
-3.976
-4.24
4.006
1.192
-3.374
-4.002
1.906
-2.161
-4.05
-2.581
-1.435
-3.328
3.778
2.95
-2.709
3.515
-2.795
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
4.70E-04
1.24E-03
6.13E-04
7.19E-05
1.13E-02
4.01E-05
3.96E-05
1.08E-04
9.51E-02
6.13E-04
6.75E-03
1.23E-03
1.10E-03
3.29E-04
6.35E-03
7.25E-03
3.22E-04
2.15E-04
1.31E-03
2.33E-05
5.13E-04
8.84E-01
1.96E-03
1.67E-03
2.28E-03
3.49E-04
2.43E-05
8.51E-05
7.98E-02
1.98E-03
9.59E-02
2.22E-03
3.11E-02
4.58E-05
3.39E-03
7.89E-03
7.34E-05
1.02E-04
2.07E-03
7.11E-02
7.51E-05
3.16E-05
8.08E-04
2.16E-03
2.58E-04
5.14E-03
4.89E-04
2.10E-03
1.77E-02
1.06E-04
6.00E-03
6.59E-01
1.58E-04
4.54E-02
5.78E-01
4.13E-04
2.75E-04
1.29E-03
2.04E-03
2.69E-05
1.46E-02
4.30E-05
6.49E-04
3.44E-05
9.96E-04
1.24E-03
2.03E-02
5.57E-05
5.01E-02
3.03E-03
2.63E-04
1.05E-02
3.36E-02
8.93E-02
1.98E-01
1.28E-01
3.95E-02
3.47E-03
3.45E-04
1.54E-04
5.63E-05
1.37E-03
5.37E-02
1.73E-01
1.05E-03
1.63E-03
2.71E-03
1.18E-04
2.62E-02
1.19E-04
9.25E-05
3.90E-05
4.42E-01
1.06E-01
5.68E-04
2.70E-04
4.87E-04
1.13E-03
2.01E-03
4.37E-03
2.48E-05
3.18E-02
1.97E-03
3.30E-02
2.84E-03
1.08E-03
5.58E-05
8.26E-02
3.64E-04
1.99E-04
1.28E-02
3.48E-01
3.10E-02
1.74E-03
3.34E-03
5.99E-03
1.89E-02
1.77E-01
5.85E-02
6.05E-02
8.28E-04
4.49E-05
3.59E-04
2.01E-03
1.73E-03
2.02E-04
3.63E-05
3.20E-05
2.91E-04
4.26E-04
7.64E-04
8.86E-02
5.15E-03
7.00E-05
2.24E-05
6.19E-05
2.33E-01
7.42E-04
6.28E-05
5.67E-02
3.07E-02
5.13E-05
9.85E-03
1.51E-01
8.73E-04
1.58E-04
3.18E-03
6.75E-03
4.40E-04
5.19E-03
4296
26769
59589
24650
66809
24659
37070
35515
61226
40168
64063
66063
46732
66685
35009
7725
33285
5304
38189
56054
57722
45972
15468
32442
61390
14311
27097
30051
25151
2903
38574
57605
21178
1119
8853
1839
14938
6801
33642
55295
22994
50923
50346
21724
35850
6439
6717
50544
42503
49012
50792
65896
4562
55114
22150
12098
7172
25224
31499
36408
36119
57810
32964
6723
350
29167
24073
37011
9355
41118
10682
15021
25985
34660
62513
51739
45036
27514
10700
56475
50786
44402
44452
758
59024
30897
61850
2275
16219
64367
54936
14136
42621
30535
11783
41168
46075
8638
21172
58997
41231
16706
4638
10802
11987
7773
45692
11846
40086
46964
60084
58948
21987
27895
66219
21085
50372
11488
8250
61241
4137
62504
60604
66471
22909
47648
13530
2013
35207
30717
51142
14232
53040
31995
48932
36971
59647
8573
60129
22046
38971
64161
52601
31688
50730
19563
3573
27558
48917
31915
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
8897
303
57447
9698
11044
9879
10367
84225
2015
2272
115265
92797
3609
23015
8459
80331
7337
58484
257144
5217
5199
122953
6558
6039
55239
3902
475
66002
874
440270
55268
64092
115294
84450
6240
2219
80095
23244
1629
57062
9774
80201
91392
5631
6427
1329
55706
55297
84525
1647
11059
79656
10553
4189
4329
23468
84135
4507
221830
6282
23593
64781
84641
25914
596
1622
9454
7832
6827
79582
4621
151516
79921
411
79810
116071
5696
4089
79707
51440
140
1535
59338
55153
2309
116843
79744
65109
79811
7940
23603
10797
762
3192
54961
83982
126375
1678
1340
5414
23360
9842
79145
566
29097
27086
85441
56655
5580
55180
79651
7268
400360
115703
25875
10095
8407
56983
4285
64105
56339
7097
51228
23353
8662
54664
9725
8874
7077
114791
683
7305
1831
1787
53346
54496
5433
5007
217
341405
11078
131118
9308
9997
8148
11325
994
3772
4680
4069
MTMR3
ANXA2P1
NDRG2
PUM1
PAPD7
DDX46
MICU1
ZMYND15
EMR1
FHIT
DDIT4L
HELB
ILF3
GOLGA8A
TPST2
DNAJC5
UBE3A
NLRC4
GCSAM
PFN2
CFP
JDP2
SLC12A2
RNASE6
OGFOD1
LAG3
ATOX1
CYP4F12
CBR3
GOLGA8B
ECHDC2
SAMSN1
PCMTD1
ZNF512
RRM1
FCN1
ZNF606
PDS5A
DBT
DDX24
BCLAF1
HKDC1
ZNF502
PRPS1
SRSF2
COX5B
NDC1
CCDC91
HOPX
GADD45A
WWP1
BEND5
HTATIP2
DNAJB9
ALDH6A1
CBX5
UTP15
MTAP
TWISTNB
S100A11
HEBP2
CERK
HIATL1
RTTN
BCL2
DBI
HOMER3
BTG2
SUPT4H1
SPAG16
MYH3
ASPRV1
TCEAL4
ARSB
PTCD2
BATF2
PSMB8
SMAD4
NOL9
HPCAL4
ADORA3
CYBA
PLEKHA1
SDAD1
FOXO3
SLC18B1
ZNF419
UPF3B
SLTM
LST1
CORO1C
MTHFD2
CA4
HNRNPU
SSH3
IFI27L2
ZNF792
TIMM8A
COX6B1
SEPT4
FNBP4
PLEKHM1
CHCHD7
AZU1
CNIH4
FOXP1
HELZ2
POLE4
PRKCD
LINS
RHBDF2
TTC4
C15orf54
ARHGAP33
LETMD1
ARPC1B
TAGLN2
POGLUT1
MIPEP
CENPK
METTL3
TLR2
GLTP
SUN1
EIF3B
TMEM106B
TMEM63A
ARHGEF7
TIMP2
TUBGCP5
BST1
TYROBP
TSC22D3
TRDMT1
TM6SF1
PRMT7
POLR2D
OSBP
ALDH2
ANKRD33
TRIOBP
DNAJC19
CD83
SCO2
TAF15
DDX42
CDC25B
KCNJ15
CEACAM6
LYZ
++++++
++++++
----------+
----------++++++
++++++
++++++
-----++++++
-----------+---++++++
++++-+
-----+-++++
----------++++++
++++++
------+++++
-----++-+++
++++++
++++++
---------------+-++++
+-+------------++++-+
---------------------------------+------------+++++
---+---+--++++++
++++++
+---------++++++
-------------+----------------++++-+
+-++++
-----+-++++
----++----++++++
++++++
-----++++++
--------?-++++++
-----++++++
-----++++++
++++++
--+-------+----++++++
++++++
+---------+++++--------------------++++++
++++++
++++++
++++++
-----++++-+
++++++
-------+---+++++
++++++
-----++++++
-----++++++
++++++
-----++++++
-+++++
++++-+
---+-++++++
-----+-+?-++-+++
------++?++
++++++
--------------------++++-+
+-++++
-----+
--------------------++++++
-----++++++
++++++
++++++
---?-++++++
--------+------+-++++
++++++
++++++
------+---++++++
---?------++---++++++
++++++
++++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6.36
6.355
-6.353
-6.352
-6.351
-6.345
6.341
6.338
6.326
-6.322
6.31
-6.292
-6.286
-6.285
6.281
6.281
-6.275
6.267
-6.264
-6.259
6.255
6.232
-6.226
6.225
-6.225
6.224
6.199
6.194
-6.194
-6.19
-6.166
6.159
-6.15
-6.144
-6.135
6.13
-6.121
-6.117
-6.112
-6.111
-6.106
-6.09
-6.089
-6.088
-6.083
6.077
-6.076
-6.074
6.071
6.069
-6.06
-6.058
6.048
-6.046
-6.041
-6.031
-6.019
-6.002
-5.998
5.988
5.984
-5.982
5.981
-5.98
-5.979
5.978
5.976
-5.97
5.959
-5.957
-5.95
5.948
-5.947
5.93
-5.927
5.926
5.907
-5.904
-5.896
-5.894
5.889
5.877
-5.876
-5.872
5.868
-5.866
-5.866
-5.862
-5.861
5.858
5.854
5.849
5.847
-5.842
5.839
5.83
-5.825
-5.821
5.817
5.813
-5.812
5.809
-5.806
5.797
5.796
-5.791
5.791
5.79
5.786
-5.784
5.781
-5.774
-5.772
5.768
-5.757
5.752
5.746
-5.743
-5.737
-5.736
-5.734
5.732
5.712
-5.709
-5.708
-5.706
-5.7
-5.688
5.686
-5.685
5.681
5.679
5.676
-5.667
5.667
-5.666
-5.663
-5.661
5.661
5.659
5.655
-5.642
-5.64
5.639
-5.638
-5.634
-5.634
5.627
5.627
5.623
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2.02E-10
2.08E-10
2.11E-10
2.12E-10
2.14E-10
2.23E-10
2.28E-10
2.32E-10
2.52E-10
2.59E-10
2.79E-10
3.13E-10
3.25E-10
3.28E-10
3.36E-10
3.37E-10
3.49E-10
3.69E-10
3.75E-10
3.89E-10
3.98E-10
4.60E-10
4.79E-10
4.83E-10
4.83E-10
4.85E-10
5.67E-10
5.85E-10
5.86E-10
6.03E-10
6.99E-10
7.33E-10
7.76E-10
8.05E-10
8.51E-10
8.78E-10
9.29E-10
9.53E-10
9.82E-10
9.93E-10
1.02E-09
1.13E-09
1.14E-09
1.15E-09
1.18E-09
1.22E-09
1.23E-09
1.25E-09
1.27E-09
1.29E-09
1.36E-09
1.38E-09
1.47E-09
1.49E-09
1.53E-09
1.63E-09
1.76E-09
1.95E-09
2.00E-09
2.13E-09
2.18E-09
2.21E-09
2.22E-09
2.23E-09
2.25E-09
2.25E-09
2.28E-09
2.37E-09
2.54E-09
2.57E-09
2.68E-09
2.71E-09
2.73E-09
3.03E-09
3.09E-09
3.10E-09
3.49E-09
3.54E-09
3.73E-09
3.78E-09
3.88E-09
4.17E-09
4.20E-09
4.30E-09
4.41E-09
4.46E-09
4.46E-09
4.57E-09
4.60E-09
4.69E-09
4.81E-09
4.94E-09
5.02E-09
5.16E-09
5.24E-09
5.56E-09
5.70E-09
5.85E-09
5.99E-09
6.12E-09
6.19E-09
6.30E-09
6.41E-09
6.75E-09
6.78E-09
6.98E-09
6.98E-09
7.03E-09
7.23E-09
7.31E-09
7.42E-09
7.75E-09
7.82E-09
8.04E-09
8.55E-09
8.83E-09
9.12E-09
9.33E-09
9.64E-09
9.70E-09
9.82E-09
9.93E-09
1.12E-08
1.14E-08
1.14E-08
1.16E-08
1.20E-08
1.29E-08
1.30E-08
1.31E-08
1.34E-08
1.35E-08
1.38E-08
1.45E-08
1.45E-08
1.46E-08
1.49E-08
1.50E-08
1.51E-08
1.52E-08
1.56E-08
1.68E-08
1.70E-08
1.71E-08
1.72E-08
1.76E-08
1.77E-08
1.83E-08
1.84E-08
1.88E-08
++-+++++
+++++-++
---+--------+-+
-----+++
---------++++-+
+++++++--+++-++
-----+-+
-+++-+++
?----??-----+------++-++-++-+
++++-+++
--+----+++-++-+
++-----++----++-++++++
+-++++-+
---------+++--+
---++-++++-+++-+++++++
-++++-++
+--+---+
-----+-+
+----+++
+++----+
--++----------+
-+-----+
+++++-++
--++-+?-------+
----++-+
---+-+++
--+----+----+-+-+--?--------+
---------+++-+----+-+---+-+-+++++++-++-++-+
---+---+
-+---??+++++--+
-----------++--+--++---++--?---+--+----++?+-++++++
+-+++--+
+------++++-+-+
----+--+
-+-+---+
-+++--++
+-+-+++-+-+---+++++++--+----+------++++++-+
---+--+-+++--++
-+--+--++++++++
--++++++
--+----+
??-+-??+--+---+
--+-+--+
++++++++
---+----------+++++++---+------+--+--------------+-+++-++-++++-+
-++----+
+++-+++-------+
+++-++-+
+-++++++
---+---+
+--????-++++++-++++++?
-----+-+
++++++-+
---+---++++++++-+++-++
---+--++
++++++++++++-++
+++-++-+
++---+--++-++++
---++--+
+-++++?+-+-+++-------+
+++---++
++++++++
----+--+
-+--+--+++---------+-+
+++-++-+
--+++---------+
------++
-------+
------+-----+++
++++++++
-?-?--+++++++-+++++++++--??++
-++---?-++-++-+
-+----?-+---------+-++
+-+++--+
+-+++--+-++++++
-+-++?--+-+----++++++----++--------+
-----+-+
+++--+++
++++++-+
++++--++
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
7782
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
6552
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
4851
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5845
8009
4829
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
7138
8009
8009
7661
6552
8009
6552
8009
8009
8009
8009
8009
7782
8009
8009
8009
8009
8009
8009
8009
8009
3.961
2.768
-4.138
-3.073
-1.354
-3.727
2.387
1.88
1.627
-3.478
3.399
-4.1
-3.576
-2.64
4.213
3.661
-2.937
3.57
-2.24
-3.722
3.818
3.247
-4.051
2.799
-1.991
3.469
3.235
2.74
-1.083
-1.06
-2.084
3.057
-4.057
-3.906
-3.679
4.119
-3.702
-1.916
-0.708
-2.192
-2.224
-3.394
-3.553
-3.867
-3.66
-0.184
-3.806
-2.58
3.982
0.72
-2.287
-3.306
3.653
-3.727
-3.687
-3.122
-2.847
-1.633
-4.011
2.782
1.588
-2.344
3.678
-1.23
-0.404
2.073
1.376
-3.088
3.826
-4.096
-3.517
4.122
-3.559
2.331
-2.002
3.963
2.284
-2.039
-1.974
-1.779
0.126
4.183
-3.373
-4.047
3.891
-3.879
-3.315
-4.114
-4.112
3.358
4.051
4.166
3.692
-3.582
2.999
4.203
-2.659
-3.224
1.148
3.47
-3.217
2.222
-4.128
3.295
2.663
-0.408
2.216
3.332
3.128
-2.534
3.9
-3.826
-2.759
2.353
-1.955
2.342
3.16
-3.328
-3.04
-2.983
-2.891
2.854
-1.278
-3.646
-3.411
-3.849
-3.452
-3.676
3.26
-1.973
1.815
3.274
2.504
-2.726
2.139
-4.181
-3.883
-2.506
3.55
0.065
3.477
-2.375
-2.401
3.48
-3.688
-2.952
-2.713
4.05
1.624
3.453
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
7.46E-05
5.63E-03
3.50E-05
2.12E-03
1.76E-01
1.94E-04
1.70E-02
6.01E-02
1.04E-01
5.06E-04
6.77E-04
4.13E-05
3.49E-04
8.30E-03
2.53E-05
2.51E-04
3.31E-03
3.58E-04
2.51E-02
1.98E-04
1.34E-04
1.17E-03
5.09E-05
5.12E-03
4.65E-02
5.22E-04
1.22E-03
6.14E-03
2.79E-01
2.89E-01
3.71E-02
2.23E-03
4.98E-05
9.38E-05
2.34E-04
3.80E-05
2.14E-04
5.53E-02
4.79E-01
2.84E-02
2.61E-02
6.88E-04
3.81E-04
1.10E-04
2.52E-04
8.54E-01
1.41E-04
9.88E-03
6.83E-05
4.71E-01
2.22E-02
9.46E-04
2.59E-04
1.93E-04
2.27E-04
1.80E-03
4.42E-03
1.02E-01
6.06E-05
5.41E-03
1.12E-01
1.91E-02
2.35E-04
2.19E-01
6.87E-01
3.81E-02
1.69E-01
2.02E-03
1.30E-04
4.20E-05
4.37E-04
3.75E-05
3.73E-04
1.98E-02
4.53E-02
7.40E-05
2.24E-02
4.14E-02
4.84E-02
7.53E-02
9.00E-01
2.87E-05
7.45E-04
5.19E-05
9.99E-05
1.05E-04
9.15E-04
3.89E-05
3.93E-05
7.85E-04
5.11E-05
3.10E-05
2.23E-04
3.41E-04
2.71E-03
2.64E-05
7.83E-03
1.26E-03
2.51E-01
5.20E-04
1.30E-03
2.63E-02
3.66E-05
9.86E-04
7.74E-03
6.83E-01
2.67E-02
8.61E-04
1.76E-03
1.13E-02
9.63E-05
1.30E-04
5.79E-03
1.86E-02
5.06E-02
1.92E-02
1.58E-03
8.74E-04
2.37E-03
2.85E-03
3.84E-03
4.32E-03
2.01E-01
2.66E-04
6.48E-04
1.19E-04
5.57E-04
2.37E-04
1.12E-03
4.85E-02
6.95E-02
1.06E-03
1.23E-02
6.42E-03
3.25E-02
2.90E-05
1.03E-04
1.22E-02
3.86E-04
9.48E-01
5.08E-04
1.75E-02
1.64E-02
5.02E-04
2.26E-04
3.16E-03
6.68E-03
5.13E-05
1.04E-01
5.54E-04
19330
64327
35283
21482
40895
52495
6620
16443
68525
21936
12610
1162
20337
46017
66107
33781
61960
11659
66928
42708
58481
67866
33174
60741
29393
11105
8396
31838
38241
3901
10218
8017
64220
23181
60584
29059
41135
4096
44901
27970
67583
42911
1474
29928
14983
51756
52629
15901
35531
48087
68374
21277
18110
38865
40807
43487
23716
31777
66628
57986
46598
551
19159
58547
47643
15327
3056
14100
28187
31503
45238
14783
8921
6529
240
8119
22858
23005
18717
58007
7469
37374
23537
20035
39539
17792
17172
43084
65301
12162
45296
44011
26410
45423
18824
34197
23617
5346
57593
58384
37069
56325
57583
12331
44699
57205
62209
67214
3152
26904
14917
27603
63872
17958
14388
36820
6697
44730
63231
34900
29782
57435
49262
66429
62551
32547
27769
3754
10308
62632
54779
39699
43351
48444
67333
64342
24563
47163
3450
54946
25162
62024
26243
15158
67678
24701
46480
22189
30018
2359
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
22847
55251
2330
166929
85476
889
8517
8761
4062
132949
11064
2852
286148
6253
8573
284013
1936
583
51056
259215
80817
9846
51317
129401
79893
51561
27141
3689
2539
23645
1178
5899
5045
7746
22868
60560
120
128646
8615
3858
586
8754
55004
50810
104
8473
22848
121512
8611
7181
23592
8880
2947
80155
3934
23174
6996
112770
284996
10491
9631
5334
2207
2073
116449
943
4172
1890
112464
1072
11261
6595
79009
130814
26118
26275
25907
115207
823
978
84803
5720
54504
54893
143884
9717
1353
89122
3320
55726
8481
81876
51255
4482
163747
80025
6832
401258
148741
10288
148423
150590
9581
23595
2720
4037
4628
116832
200132
83891
1298
3430
4066
29102
1756
131450
2203
3823
56670
59084
84062
10924
29080
55082
1200
79048
80110
89978
10152
51538
79684
26273
5325
27348
55301
163255
57728
2350
6432
57466
23512
400668
23164
9404
3738
58190
28514
2769
9246
273
ZNF507
PCMTD2
FMO5
SGMS2
GFM1
KRIT1
IKBKG
PABPC4
LY6H
AASDH
CNTRL
GPER
DPY19L4
RTN2
CASK
VMO1
EEF1D
BBS2
LAP3
LY6G6F
CEP44
GAB2
PHF21A
NUP35
GGNBP2
IL23A
CIDEB
ITGB2
G6PD
PPP1R15A
CLC
RALB
FURIN
ZSCAN9
FASTKD2
NAA35
ADD3
SIRPD
USO1
KRT10
BCAT1
ADAM9
LAMTOR1
HDGFRP3
ADARB1
OGT
AAK1
FGD4
PPAP2A
NR2C1
LEMD3
FUBP1
GSTM3
NAA15
LCN2
ZCCHC14
TDG
C1orf85
RNF149
CRTAP
NUP155
PLCL1
FCER1G
ERCC5
CLNK
TNFRSF8
MCM3
TYMP
PRKCDBP
CFL1
CHP1
SMARCA2
DDX50
PQLC3
WSB1
HIBCH
TMEM158
KCTD12
CAPN1
CDA
AGPAT9
PSME1
CPVL
MTMR10
CWF19L2
SEC14L5
COX11
TRIM4
HSP90AA1
ASUN
OFD1
RAB1B
RNF181
MSRA
C1orf177
PANK2
SUPV3L1
RAB44
ANKRD35
LILRB2
C1orf52
C2orf15
PREPL
ORC3
GLB1
LRP3
MYH10
RPL39L
TCTEX1D1
SNX25
COL9A2
IFI35
LYL1
DROSHA
DMD
CD200R1
FBP1
KLRC3
SUCNR1
ENPP5
DTNBP1
SMPDL3A
CCDC59
ARGLU1
TPP1
SECISBP2
ZNF614
DPH6
ABI2
ZCCHC17
MSANTD2
FBXO3
PLAGL1
TOR1B
OLAH
ZNF540
WDR19
FOLR2
SRSF7
SCAF4
SUZ12
PRSS57
MPRIP
LPXN
KCNA3
CTDSP1
DLL1
GNA15
UBE2L6
AMPH
+------+--++++++
--++++
----------++-+++
---+-++++++
----------++++++
-----+++-++
+----++-+++
----------++++++
++--++
-----++++-+
++++++
---------------++++-+
++++++
++++++
+++-++
++++++
+-++++
+++++++++-+
---+-----------++++-+
--+-------+-++++
++++++
++++++
+-++++
----+----------++++++
-----------------------+----+-++++++
----------++++++
++++-+
--++++
----------++++++
-----++++++
++++-+
------+++-+
++++++
++-+-+
++++++
--+-------+-++++
+-++++
-----++++++
-+++++
++-+++
++++-+
++++-+
++-+-+
-+++++
----------++--++
------------+------------++++++
-+++++
++++++
++++++
++++++
-----++++++
++++++
++++++
--+---------+-----?-+-++++
++++++
-+---++-+++
++++++
-----++++++
++++++
++-+++
-----++++++
---?-+++?++
++++++
++++++
++++++
++-+++
++++-+
-------+--++-+++
-------------+------++++++
-------+--++++-+
++++++
++++++
-----------+++-+
------+-----+--++++++
+--------------++++-+
-----+
++++++
++-+++
+++?++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
-5.621
-5.618
5.613
5.611
-5.609
-5.607
5.606
-5.604
5.596
-5.589
-5.588
5.586
-5.582
5.572
-5.57
5.569
-5.563
-5.559
5.55
5.55
-5.547
5.547
5.546
-5.544
-5.542
-5.534
5.53
5.527
5.526
5.523
5.522
5.519
5.518
5.515
-5.507
-5.503
-5.496
5.486
-5.485
-5.484
5.476
5.474
5.469
5.464
-5.463
-5.463
-5.461
5.459
-5.449
-5.448
-5.448
-5.448
-5.445
-5.442
5.438
-5.437
-5.436
5.428
5.422
5.418
-5.409
-5.405
5.403
-5.402
5.392
5.389
-5.386
5.385
5.382
5.375
5.372
-5.371
-5.366
5.36
5.36
-5.359
5.355
5.35
5.347
5.344
5.342
5.34
5.334
-5.331
-5.331
5.33
-5.328
-5.327
-5.326
-5.323
-5.321
5.316
5.315
5.314
5.304
5.299
-5.291
5.284
5.283
5.279
-5.276
-5.272
-5.272
-5.266
5.262
5.261
-5.261
5.26
5.258
-5.258
5.254
5.252
5.25
-5.249
5.247
-5.247
5.247
5.245
5.241
5.238
5.235
5.233
-5.232
-5.228
5.223
-5.214
-5.213
-5.211
-5.208
5.208
-5.195
-5.195
5.188
5.186
5.183
-5.182
-5.174
5.168
-5.165
-5.164
-5.164
5.163
-5.163
-5.16
-5.159
5.155
-5.153
5.148
5.145
5.144
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.90E-08
1.93E-08
1.99E-08
2.01E-08
2.03E-08
2.06E-08
2.07E-08
2.09E-08
2.19E-08
2.29E-08
2.30E-08
2.32E-08
2.38E-08
2.52E-08
2.54E-08
2.56E-08
2.65E-08
2.72E-08
2.85E-08
2.86E-08
2.90E-08
2.91E-08
2.92E-08
2.95E-08
2.98E-08
3.13E-08
3.21E-08
3.25E-08
3.28E-08
3.34E-08
3.35E-08
3.41E-08
3.43E-08
3.48E-08
3.65E-08
3.73E-08
3.89E-08
4.11E-08
4.14E-08
4.15E-08
4.35E-08
4.40E-08
4.54E-08
4.65E-08
4.67E-08
4.68E-08
4.72E-08
4.79E-08
5.06E-08
5.08E-08
5.09E-08
5.09E-08
5.19E-08
5.27E-08
5.39E-08
5.43E-08
5.44E-08
5.69E-08
5.90E-08
6.03E-08
6.32E-08
6.47E-08
6.54E-08
6.58E-08
6.97E-08
7.08E-08
7.21E-08
7.23E-08
7.36E-08
7.66E-08
7.78E-08
7.84E-08
8.04E-08
8.30E-08
8.33E-08
8.36E-08
8.54E-08
8.77E-08
8.95E-08
9.07E-08
9.22E-08
9.30E-08
9.63E-08
9.75E-08
9.77E-08
9.80E-08
9.96E-08
9.97E-08
1.01E-07
1.02E-07
1.03E-07
1.06E-07
1.07E-07
1.07E-07
1.13E-07
1.16E-07
1.21E-07
1.27E-07
1.27E-07
1.30E-07
1.32E-07
1.35E-07
1.35E-07
1.40E-07
1.42E-07
1.43E-07
1.43E-07
1.44E-07
1.45E-07
1.46E-07
1.49E-07
1.50E-07
1.52E-07
1.53E-07
1.55E-07
1.55E-07
1.55E-07
1.56E-07
1.60E-07
1.62E-07
1.65E-07
1.67E-07
1.67E-07
1.72E-07
1.76E-07
1.84E-07
1.86E-07
1.88E-07
1.91E-07
1.91E-07
2.04E-07
2.05E-07
2.12E-07
2.15E-07
2.18E-07
2.20E-07
2.30E-07
2.36E-07
2.40E-07
2.42E-07
2.42E-07
2.43E-07
2.44E-07
2.47E-07
2.48E-07
2.53E-07
2.57E-07
2.63E-07
2.68E-07
2.69E-07
+-+?+-?-------+
+-++-+-+
+-+?+-?+
---0---+
--+---+++-+++-+
-----+-+
+-+++-?+
--------+---+-+-+-++-+
?++--??+-++++++
++-+---+
?+++++?---+----------+
-+++++++
-+++++-+
-------+
+-++++-+
+++--+++
-+---+---+----+
---+---++--++-+
++--++++
+-+-++++
++++++-+
--+++-+++++++-+
++-+-+++
++++++-+
-+---+--+----+-------+
+-+-++-+
--------------+-+++--+
++++-+?+
+-+++-++
?+-?-??+
---+--++
-------+
-+---+-+
?-+?-??+
++-+-??---------+-+--------?+--+-+-+-+----+++++---------+
--+----++++++-+
+-+-++++
+++---++
--++------+--++++++++-----+-+
-++++??+
+-++++++
-------+
++++++++++++++---+++++
---++--+
---+---+
--+-----++--+++
+++-++-+
-+-----+
++++++++++-+++-+-+-+-+
++++++-+
+++-++-+
-+++++++
+-+-+-+-----+-+
-++-----+-++++?--+-??-------+
---+----+----+-----+++-++++++
--+++-+++++++-+
+++-++-+
-+++-+-+
-+----++
--++++++
++++++++++---++
--+-------+-----+----+
--+----+
++-+++-+
+-++++-+
?--????+
++++++++
?++++??-+-+-??+
--+++++-+++++++
++++-++-----+-+
-++++++-++---+-++++-++
-++-++-+
++++++++
-++-++?+
-++-++-+
+++++--+
-+++-----------+-+-+++
-----+-+
--+--+----+--------+-+
-++++--+
-+----+-+-----+
+++-+--+
++++++++
?++?-??+
+-----------+---++++-+
--+-------+--+--+----+
+++?++----+---+
-------+
?+-+++?+
---+++-+
---+-+?+++++-+-+++++++
?-++-??+
6193
8009
8009
6193
8009
8009
8009
8009
6552
8009
8009
8009
5363
8009
8009
5590
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
5004
8009
8009
8009
5004
6325
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
4883
8009
5363
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5004
8009
8009
8009
8009
8009
8009
7650
8009
8009
5590
8009
6552
8009
8009
5363
-2.139
-2.42
2.529
3.374
-2.568
-1.414
1.262
-3.847
2.1
-4.218
-2.842
0.895
-2.89
2.182
-1.306
2.069
-3.262
-1.465
3.91
1.168
-2.689
3.984
3.832
-2.855
-1.279
-4.23
2.983
3.603
1.72
3.999
0.838
3.624
3.834
2.392
-4.178
-1.533
-3.03
3.422
-3.71
-4.139
4.043
2.698
2.874
3.432
-2.193
-2.392
-1.073
2.55
-2.217
-3.56
-2.527
-4.036
-3.646
-2.384
1.784
-3.884
-3.318
1.995
3.119
3.646
-2.691
-1.119
4.21
-2.481
2.979
3.154
-3.929
4.018
3.506
2.073
0.6
-3.138
-3.158
3.94
3.654
-4.223
2.041
2.792
2.074
3.807
2.459
2.869
0.858
-2.749
-3.539
0.359
-1.436
-2.659
-3.842
-2.482
-2.791
4.027
1.625
2.979
2.295
3.145
-0.839
2.411
2.074
2.647
-2.906
-3.914
-2.235
-2.926
3.612
3.18
-2.413
4.057
0.798
0.24
1.749
3.942
3.722
-3.798
0.837
0.188
3.043
1.848
3.823
1.671
3.183
2.332
-3.391
-3.092
4.203
-1.475
-4.04
-3.57
-1.457
3.935
-3.044
-1.333
1.153
3.97
1.392
-3.295
-3.492
1.851
-3.095
-1.663
-1.902
-0.253
-3.298
-3.793
1.828
1.143
-3.235
2.714
3.383
1.166
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3.25E-02
1.55E-02
1.15E-02
7.40E-04
1.02E-02
1.57E-01
2.07E-01
1.20E-04
3.57E-02
2.46E-05
4.49E-03
3.71E-01
3.85E-03
2.91E-02
1.92E-01
3.85E-02
1.11E-03
1.43E-01
9.22E-05
2.43E-01
7.17E-03
6.77E-05
1.27E-04
4.30E-03
2.01E-01
2.33E-05
2.86E-03
3.14E-04
8.55E-02
6.37E-05
4.02E-01
2.90E-04
1.26E-04
1.68E-02
2.94E-05
1.25E-01
2.45E-03
6.22E-04
2.08E-04
3.48E-05
5.28E-05
6.98E-03
4.06E-03
6.00E-04
2.83E-02
1.67E-02
2.84E-01
1.08E-02
2.66E-02
3.70E-04
1.15E-02
5.44E-05
2.67E-04
1.71E-02
7.45E-02
1.03E-04
9.06E-04
4.61E-02
1.81E-03
2.67E-04
7.12E-03
2.63E-01
2.55E-05
1.31E-02
2.89E-03
1.61E-03
8.52E-05
5.86E-05
4.55E-04
3.81E-02
5.49E-01
1.70E-03
1.59E-03
8.16E-05
2.58E-04
2.41E-05
4.12E-02
5.24E-03
3.81E-02
1.41E-04
1.39E-02
4.12E-03
3.91E-01
5.98E-03
4.02E-04
7.20E-01
1.51E-01
7.85E-03
1.22E-04
1.31E-02
5.26E-03
5.64E-05
1.04E-01
2.89E-03
2.17E-02
1.66E-03
4.01E-01
1.59E-02
3.81E-02
8.12E-03
3.66E-03
9.07E-05
2.54E-02
3.43E-03
3.04E-04
1.47E-03
1.58E-02
4.98E-05
4.25E-01
8.10E-01
8.03E-02
8.07E-05
1.98E-04
1.46E-04
4.03E-01
8.51E-01
2.34E-03
6.46E-02
1.32E-04
9.48E-02
1.46E-03
1.97E-02
6.98E-04
1.99E-03
2.64E-05
1.40E-01
5.35E-05
3.58E-04
1.45E-01
8.33E-05
2.34E-03
1.83E-01
2.49E-01
7.19E-05
1.64E-01
9.85E-04
4.80E-04
6.41E-02
1.97E-03
9.63E-02
5.71E-02
8.00E-01
9.74E-04
1.49E-04
6.75E-02
2.53E-01
1.22E-03
6.65E-03
7.16E-04
2.44E-01
5466
38747
13753
12284
65730
61630
51707
35331
1688
42654
1791
66908
13575
61177
3735
44226
53462
63528
52511
49367
57905
32815
54526
67899
12965
37051
10490
19277
33858
31018
4123
12594
47000
36989
35988
43829
57548
14023
31629
40940
21522
46210
63423
26371
31866
31870
8106
39366
12901
18072
67750
60463
58047
68327
44893
8778
67775
33060
8653
21738
51927
52303
61592
58038
12397
65911
1924
53666
26561
1896
21674
772
58771
59682
63133
29096
41055
22241
29193
27119
15484
5026
9014
50995
2880
17304
15713
67159
34794
15343
18104
35721
40317
8875
66788
60836
29144
850
26822
22342
27332
62724
40039
13002
57647
406
53423
39376
31965
6972
25243
9557
20903
19199
3580
22740
62327
853
65690
2935
53070
66683
25250
19169
45079
68009
16088
22930
30801
9730
38279
13788
967
18883
51128
68044
66212
58117
27882
5651
53949
27140
28995
60117
57454
40020
32924
15070
60898
48015
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
79895
112942
1088
10914
9310
2712
7168
51367
55164
2359
5158
55893
54665
147495
5775
54811
9847
29924
29085
1453
5914
1407
79667
84255
10487
10346
5499
9911
60561
253769
23195
90678
1742
6741
634
126014
10513
29083
55070
6730
9816
9473
116143
5051
5552
55671
122773
2537
51727
3727
6294
29992
29760
55703
25915
56829
5588
11282
317649
5141
55968
1854
894
2512
7384
8669
65251
84617
11169
8809
5657
9168
10443
1070
7756
7905
1020
2067
2212
55197
2395
11097
5859
52
23215
4676
5832
10153
8939
27122
26278
7748
352954
1727
1991
9135
10527
55255
5547
9524
1730
55278
10260
222236
1030
55596
5315
54461
820
158471
60496
6205
79705
3071
4005
51310
4856
1124
2969
10478
8165
83871
8100
8309
10109
10236
64968
5862
5725
64748
10562
90139
196883
29108
121506
3620
54939
94097
117144
55339
7693
10592
3796
162655
9064
1522
689
8697
55737
26098
ATP8B4
CCDC104
CEACAM8
PAPOLA
ZNF235
GK2
TPM1
POP5
SHQ1
FPR3
PDE6B
ZNF395
RSBN1
APCDD1
PTPN4
ZNF562
C2CD5
EPN1
PHPT1
CSNK1D
RARA
CRY1
RP11-617D20.1
SLC37A3
CAP1
TRIM22
PPP1CA
TMCC2
RINT1
WDR27
MDN1
LRSAM1
DLG4
SSB
CEACAM1
OSCAR
APPBP2
GTPBP8
DET1
SRP68
URB2
THEMIS2
WDR92
PAFAH2
SRGN
SMEK1
KLHDC1
IFI6
CMPK1
JUND
SAFB
PILRA
BLNK
POLR3B
NDUFAF3
ZC3HAV1
PRKCQ
MGAT4B
EIF4E3
PDE4A
NSFL1C
DUT
CCND2
FTL
UQCRC1
EIF3J
ZNF649
TUBB6
WDHD1
IL18R1
PRTN3
TMSB10
N4BP2L2
CETN3
ZNF207
REEP5
CDK5
ERCC1
FCGR2A
RPRD1A
FXN
NUPL2
QARS
ACP1
PRRC2C
NAP1L4
ALDH18A1
CEBPZ
FUBP3
DKK3
SACS
ZNF195
GATS
CYB5R3
ELANE
RABEP1
IPO7
WDR41
PRCP
TECR
DIAPH2
QRSL1
DENND4A
NAPEPLD
CDKN2B
ZCCHC8
PKM
FBXW5
CAMP
PRUNE2
AASDHPPT
RPS11
LRRK1
NCKAP1L
LMO2
SLC22A17
NOV
CHN2
GTF2I
SLC25A17
AKAP1
RAB34
IFT88
ACOX2
ARPC2
HNRNPR
MRPS6
RAB2A
PTBP1
DKFZP761J1410
OLFM4
TSPAN18
ADCY4
PYCARD
ERP27
IDO1
COMMD4
SFXN5
CATSPER1
WDR33
ZNF134
SMC2
KIF2A
ZNF519
MAP3K6
CTSZ
BTF3
CDC23
VPS35
C10orf137
+-++++
-----++++++
+-++------++++++
+++++----------+-++++
---?-----------+++?++
++-+++
----------++++++
++++-+
++++++
++++-+
+-------?-+-+-++
+-++-+
++++++
-+++++
++++++
---------------++++++
+++?++
---?-++++++
++++++
--------+----+-----------++++++
--+?-++++++
+++++------+--+-+++++
--+--++++++
-----++++-+
-+--------++-+++
----------++++++
++++++
++++-+
-+++-+
--+--+----++++++
++-+++
--+-------+-++++
-+---+-++-+
++++++
++++-+
-------------+-+-++-+
++++-+
-+++++
++++++
--------?-----------+
---+++--------+---?----------------+-+-------++++++
++-+++++++--------+-+-++++
++++-+
-----++++++
-----+---------++++++
-----++-+++
++++++
++++++
+-+-++
--------+-++++-+
++++-+
++++++
-----++++-+
++++++
---?--------+--++++-+
-----+-++++
++++-+
--------+-++++++
-----+
++++-+
+--+++
+----++++-+
++++++
-----++++++
++++++
-+++-+
+-++++
+--------------+-------+-++-+++
++++-+
---+------+
-------+---
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
5.14
-5.14
5.139
-5.138
-5.134
5.132
5.131
-5.127
-5.125
5.121
-5.118
-5.112
-5.103
5.098
5.098
-5.098
-5.097
5.093
5.092
5.091
5.089
-5.085
-5.081
5.081
5.081
5.073
5.073
5.072
-5.072
-5.07
-5.069
5.067
5.066
-5.066
5.059
5.053
-5.052
-5.052
-5.042
-5.042
-5.041
5.041
-5.04
5.038
5.038
-5.037
-5.031
5.03
-5.029
5.029
-5.028
5.026
-5.026
-5.026
5.026
-5.02
-5.02
5.019
5.018
5.017
5.016
-5.013
-5.013
5.012
5.008
-5.006
-5.006
4.998
-4.998
4.997
4.993
4.991
-4.99
-4.989
-4.989
4.987
4.986
4.985
4.984
-4.983
-4.983
-4.98
-4.978
-4.977
-4.974
-4.972
-4.97
-4.969
-4.969
-4.965
-4.963
-4.962
4.957
4.956
4.954
-4.95
-4.949
4.945
4.945
-4.942
4.942
-4.941
-4.939
-4.939
4.938
-4.936
4.935
4.933
4.931
4.928
-4.916
-4.915
4.914
4.909
4.907
-4.901
4.9
4.899
-4.898
-4.898
-4.898
4.897
-4.894
4.883
4.874
-4.872
-4.87
4.869
-4.868
4.868
4.867
-4.866
4.861
4.86
-4.858
4.858
4.856
4.854
4.854
-4.85
-4.849
-4.847
-4.842
-4.836
4.834
4.83
-4.828
-4.825
-4.821
-4.819
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.75E-07
2.75E-07
2.77E-07
2.78E-07
2.84E-07
2.87E-07
2.89E-07
2.95E-07
2.98E-07
3.04E-07
3.09E-07
3.19E-07
3.34E-07
3.43E-07
3.43E-07
3.44E-07
3.46E-07
3.52E-07
3.54E-07
3.55E-07
3.60E-07
3.67E-07
3.76E-07
3.76E-07
3.76E-07
3.92E-07
3.92E-07
3.93E-07
3.94E-07
3.98E-07
3.99E-07
4.04E-07
4.06E-07
4.06E-07
4.21E-07
4.34E-07
4.37E-07
4.38E-07
4.60E-07
4.62E-07
4.63E-07
4.64E-07
4.66E-07
4.70E-07
4.71E-07
4.73E-07
4.88E-07
4.91E-07
4.93E-07
4.93E-07
4.96E-07
5.00E-07
5.00E-07
5.00E-07
5.02E-07
5.17E-07
5.17E-07
5.20E-07
5.21E-07
5.25E-07
5.29E-07
5.36E-07
5.37E-07
5.40E-07
5.49E-07
5.55E-07
5.57E-07
5.79E-07
5.80E-07
5.82E-07
5.96E-07
6.02E-07
6.05E-07
6.08E-07
6.09E-07
6.15E-07
6.15E-07
6.21E-07
6.21E-07
6.27E-07
6.27E-07
6.37E-07
6.42E-07
6.47E-07
6.55E-07
6.62E-07
6.69E-07
6.72E-07
6.74E-07
6.87E-07
6.94E-07
6.97E-07
7.16E-07
7.19E-07
7.27E-07
7.41E-07
7.45E-07
7.61E-07
7.61E-07
7.74E-07
7.75E-07
7.76E-07
7.85E-07
7.85E-07
7.89E-07
7.97E-07
8.02E-07
8.10E-07
8.18E-07
8.33E-07
8.83E-07
8.89E-07
8.91E-07
9.16E-07
9.25E-07
9.52E-07
9.58E-07
9.61E-07
9.68E-07
9.69E-07
9.69E-07
9.74E-07
9.87E-07
1.05E-06
1.09E-06
1.11E-06
1.12E-06
1.12E-06
1.13E-06
1.13E-06
1.13E-06
1.14E-06
1.17E-06
1.17E-06
1.18E-06
1.19E-06
1.20E-06
1.21E-06
1.21E-06
1.24E-06
1.24E-06
1.25E-06
1.29E-06
1.32E-06
1.34E-06
1.36E-06
1.38E-06
1.40E-06
1.43E-06
1.44E-06
++++--+++-+---+
+++++0----+-----+----?++++??+++-+-++
--+-----+-----?+0+-??+
-+--------+-+-+
-+-----+
-+++--++++++-+----++----+---+
++--++++
--++++++
++++++-+
++++++++
-+-+---+++-+-++++--+-+
++++++-+
+++--+++
--++++-+
++-++-++
--+--+----+--++----+0+-+-++++
-+++++++
--++---++++++++
+-+++-++
--+----+
-++----+
--------------+
---+--++-++++++
--------++-++-+
+++-++++
-+---+--+-????+++++++---+---+
++-++++-----+-+?++++-+
--+???+-+--++--+++++--+---+-+
-----+-+
--++++-+
+++-+-++-+---++
+-++++-+
------?++-+--++
++-++++-+++++++
-+---+-+-+--??-+++---+
--++?-++++-++-+
?++++??--++--++
--+---+++++-+---++++---++---+
-+-++-++
--+++-++++-++++
--+++--+
?--????--+--------+--+
-+------+---+-+
-+-+--+-------+
---------+----+----??+-----?---+-++-++++--+
-+-++-++
++++++---+----?++-???-++-+--+
--+++--+
-----+-+
-+++++++
+--?-??-+----+-+----+++++--+-+---+++
--++-+++
+-++++++
+++++--+
-++-+??-------+
-------?++++??+
----++++
+-+++--+----+--++++--+
-+-++-++
-+--+-+----+--+
-----??+-+++-++
---+--+?++?+??+
++++++++
-+--+++---+---+-++++-+
------++-++++++
++++++-?-+?++?+
+++-++-+
++++++++
----++--?+?--++
-+++++++
+++-++-+
+-++++------+-+
-------+
+-+-----+-+---?+-?+??+-++--++
-+++++++
-+----+----+--+
---+---+
---+---+
8009
8009
8009
8009
8009
5363
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5845
8009
8009
8009
8009
7497
7302
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
8009
6325
8009
7888
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
8009
4883
8009
8009
8009
8009
8009
8009
8009
8009
6325
6552
8009
8009
8009
8009
8009
5242
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
5004
8009
8009
8009
8009
8009
8009
8009
5231
8009
8009
8009
7138
8009
8009
8009
8009
8009
8009
8009
5004
8009
8009
8009
8009
8009
8009
3.345
-0.243
0.981
-3.998
-3.263
-0.144
4.143
-3.826
-2.678
2.465
-3.842
-2.905
-1.226
0.417
3.365
-4.114
-2.949
1.148
2.902
3.765
3.712
-2.279
-1.928
3.912
3.834
3.913
2.243
3.444
-1.33
-2.798
-1.45
0.711
2.141
-3.02
3.093
2.599
-3.808
-1.868
-3.874
-3.291
-3.869
3.506
-4.125
1.917
3.829
-3.653
-3.528
2.028
-2.758
2.904
-4.22
2.526
-3.205
-2.149
-0.086
-0.389
-1.761
1.597
2.134
2.522
2.294
-4.19
2.01
1.218
3.653
-2.612
-1.206
2.191
-1.45
4.057
0.232
-0.206
-1.303
-2.6
-3.015
2.85
1.618
0.592
3.674
-2.533
-2.801
-3.034
-4.013
-3.922
-2.343
-2.201
-3.119
-4.123
-3.307
-3.409
-3.518
-1.73
1.114
3.016
3.53
-3.778
-2.391
2.896
0.701
-2.786
4.02
-3.625
-1.325
-2.42
0.325
-1.021
4.024
2.572
2.659
-1.307
-3.067
-3.674
2.13
2.793
0.805
-3.915
1.942
1.337
-1.419
-0.95
-1.609
3.831
-1.831
2.266
3.688
-2.888
-3.822
0.554
-3.56
2.359
0.584
0.247
2.52
3.851
-3.164
0.269
3.276
3.388
1.761
-3.811
-3.783
-4.166
-2.664
-2.2
4.2
3.065
-2.805
-2.438
-3.55
-3.674
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
8.23E-04
8.08E-01
3.27E-01
6.39E-05
1.10E-03
8.86E-01
3.43E-05
1.30E-04
7.41E-03
1.37E-02
1.22E-04
3.67E-03
2.20E-01
6.77E-01
7.66E-04
3.89E-05
3.19E-03
2.51E-01
3.71E-03
1.67E-04
2.06E-04
2.27E-02
5.39E-02
9.14E-05
1.26E-04
9.11E-05
2.49E-02
5.74E-04
1.84E-01
5.15E-03
1.47E-01
4.77E-01
3.23E-02
2.53E-03
1.98E-03
9.35E-03
1.40E-04
6.17E-02
1.07E-04
9.97E-04
1.10E-04
4.55E-04
3.71E-05
5.53E-02
1.29E-04
2.59E-04
4.19E-04
4.26E-02
5.82E-03
3.68E-03
2.44E-05
1.15E-02
1.35E-03
3.17E-02
9.32E-01
6.98E-01
7.83E-02
1.10E-01
3.29E-02
1.17E-02
2.18E-02
2.78E-05
4.45E-02
2.23E-01
2.60E-04
8.99E-03
2.28E-01
2.84E-02
1.47E-01
4.96E-05
8.17E-01
8.37E-01
1.93E-01
9.31E-03
2.57E-03
4.38E-03
1.06E-01
5.54E-01
2.39E-04
1.13E-02
5.09E-03
2.42E-03
6.00E-05
8.80E-05
1.92E-02
2.77E-02
1.81E-03
3.73E-05
9.42E-04
6.52E-04
4.36E-04
8.36E-02
2.65E-01
2.56E-03
4.16E-04
1.58E-04
1.68E-02
3.78E-03
4.83E-01
5.34E-03
5.82E-05
2.89E-04
1.85E-01
1.55E-02
7.45E-01
3.07E-01
5.72E-05
1.01E-02
7.85E-03
1.91E-01
2.17E-03
2.39E-04
3.32E-02
5.23E-03
4.21E-01
9.04E-05
5.21E-02
1.81E-01
1.56E-01
3.42E-01
1.08E-01
1.27E-04
6.71E-02
2.35E-02
2.26E-04
3.88E-03
1.33E-04
5.80E-01
3.71E-04
1.83E-02
5.60E-01
8.05E-01
1.17E-02
1.18E-04
1.56E-03
7.88E-01
1.05E-03
7.03E-04
7.83E-02
1.39E-04
1.55E-04
3.10E-05
7.73E-03
2.78E-02
2.67E-05
2.18E-03
5.03E-03
1.48E-02
3.86E-04
2.39E-04
55208
2488
2513
43366
11314
60459
51628
16988
44998
54652
8176
1892
32773
54303
1361
58130
15740
65128
12347
59363
31853
40190
12787
13659
48715
6365
24699
65618
29993
9058
30352
46848
29316
26157
66922
38819
60735
24471
32571
16952
45447
15961
57321
23405
41156
39780
5998
35524
28485
8324
16380
52535
30989
52015
3109
50519
33203
21925
49988
26451
39452
63683
41303
57070
55050
26845
44717
46560
3455
17941
4026
28768
52258
32968
21353
62928
62304
6073
26784
1622
14922
41242
22435
2029
15035
36186
40859
54155
8164
18050
8469
25651
11936
64008
62108
16397
493
8467
20251
38417
50552
38267
4136
13287
20119
40111
20568
15294
35397
60923
51300
14534
16040
60575
61594
60285
56846
5476
56880
12628
31701
59599
59349
9839
25118
63400
45469
34291
13634
8337
25919
26584
24752
34959
56185
19343
57584
51168
60669
57315
1847
31090
64612
48920
14464
52200
26078
61775
38570
34104
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
y
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
29902
9619
63979
167681
3178
7976
92979
4218
7750
5422
22852
58478
152195
374868
57690
11276
5355
9657
64979
7439
1523
23077
4145
60592
6813
113510
23172
255022
11198
123041
8450
400863
898
58517
55149
54470
51455
1737
23151
201595
8871
79986
666
51130
25840
11137
65117
149483
54207
2745
57695
7227
79447
51678
4580
8732
51192
6303
56477
23173
686
8028
57337
26589
26036
2217
4085
285381
171558
3628
160518
89853
134430
23678
10969
51175
23310
10217
9798
1152
11332
57602
55501
80790
581
53916
143689
6311
26190
11180
10282
22796
28512
11100
284185
22921
55466
55103
64744
317671
9652
65123
57511
10057
115286
2137
79007
1378
4071
23471
10467
11052
57488
5813
29922
85012
875
84106
79850
440
7408
90317
79886
58488
84181
3384
5699
23142
386757
23613
7422
55020
51237
6932
348378
81552
10474
202134
26509
54433
388524
10392
79694
4674
64921
197259
10904
9985
6556
51522
FAM216A
ABCG1
FIGNL1
PRSS35
HNRNPA1
FZD3
MARCH9
RAB8A
ZMYM2
POLA1
ANKRD26
ENOPH1
NUDT16P1
ATP9B
TNRC6C
SYNRG
PLP2
IQCB1
MRPL36
BEST1
CUX1
MYCBP2
MATK
SCOC
STXBP2
HELQ
FAM175B
CALHM1
SUPT16H
SLC24A4
CUL4B
LINC00649
CCNE1
RBM25
MTPAP
ARMCX6
REV1
DLAT
GRAMD4
STT3B
SYNJ2
ZNF702P
BOK
ASB3
METTL7A
PWP1
RSRC2
CCDC17
KCNK10
GLRX
USP37
TRPS1
PAGR1
MPP6
MTX1
RNGTT
CKLF
SAT1
CCL28
METAP1
BTD
MLLT10
SENP7
MRPL46
ZNF451
FCGRT
MAD2L1
DPH3
PTCRA
INPP1
DENND5B
MVB12B
WDR36
SGK3
EBNA1BP2
TUBE1
NCAPD3
CTDSPL
IST1
CKB
ACOT7
USP36
CHST12
CMIP
BAX
RAB4B
PIWIL4
ATXN2
FBXW2
WDR6
BET1
COG2
NKIRAS1
HNRNPUL1
LINC00482
MSRB2
DNAJA4
RALGPS2
SMAP2
RFESD
TTC37
INTS3
COG6
ABCC5
SLC25A26
EXTL3
DBNDD1
CR1
TM4SF1
TRAM1
ZNHIT1
CPSF6
ESYT2
PURA
NME7
TCEAL3
CBS
PRAM1
FAM57A
ASNS
VASP
ZNF616
CAAP1
PCTP
CHD6
ICAM2
PSMB10
DCUN1D4
SLC6A10P
ZMYND8
VEGFA
TTC38
MZB1
TCF7
FAM159A
VOPP1
TADA3
FAM153B
MYOF
GAR1
RPSAP15
NOD1
MANEA
NAP1L2
CASD1
MLKL
BLCAP
REC8
SLC11A1
TMEM14C
--+--+++-++
--------------+----------++++++
+-+---+----+--------+
++++++
+-------------+++++-+
--------+-++++-+
++++-+
-----++-+++
--+--++++++
----------++++++
----+++++++
---+-------------+?----+----?---+-------++++++
---------+---+-++++++
-----+-++++
---+---+--++++++
++--++
--++++
---+-+-++-+
----------++++++
-----++++++
+++++--------+-+++-++
+------+-------------+++++
-----++++++
++-++++-+++
---?-++-+++
----++-++++
-------------+-++-++-----++-+++
++-+++
-----++-+++
++++-+
++-+++
++++++
++++++
++---++++++
-----+
------------+-------+++-++
-+++++
-+--+------+++++
----------+++?-+
---+-++++++
-----++++++
-----+
++++++
+++-++
------+++++
+++----------------------+
++++++
++++-+
-+--------+++?++
----------++++++
+--------+++-+++
-----++-+++
-----++++++
++++++
---------------++++++
++++++
-----++++++
----+---?-++-+++
-----++--++
---+-++++++
-----++++-+
++++++
---+--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
-4.819
4.818
-4.817
-4.816
-4.812
-4.812
-4.81
4.808
-4.807
-4.805
-4.802
-4.801
4.798
-4.796
-4.792
-4.789
4.787
-4.787
-4.784
4.782
4.779
-4.777
4.777
-4.774
4.768
-4.766
-4.763
4.761
-4.76
4.76
-4.756
-4.753
-4.752
-4.747
-4.746
-4.745
-4.744
-4.743
4.742
-4.74
-4.739
-4.737
4.737
-4.732
4.731
-4.731
-4.73
4.728
4.726
4.724
-4.718
4.715
-4.713
-4.71
4.707
-4.705
4.705
4.703
-4.699
-4.699
4.698
-4.694
-4.693
-4.693
-4.686
4.685
-4.682
4.682
4.679
4.678
-4.675
4.672
-4.67
4.67
-4.668
-4.668
-4.666
4.665
-4.665
4.664
4.664
-4.663
4.663
4.662
4.659
4.659
4.658
-4.657
4.655
-4.651
-4.65
-4.647
-4.645
-4.645
4.642
4.64
-4.639
-4.638
4.636
-4.636
-4.633
4.63
-4.629
4.629
-4.627
4.627
-4.626
4.626
4.624
-4.623
4.622
-4.621
-4.621
-4.616
-4.616
-4.615
4.614
4.612
-4.611
-4.61
4.61
-4.609
-4.608
4.608
-4.608
-4.608
4.606
-4.606
4.603
-4.602
4.602
13.274
-8.528
-8.459
-7.788
6.691
5.761
-5.105
5.079
-4.951
-4.67
4.601
-4.601
4.601
-4.6
4.6
-4.6
4.598
4.597
-4.596
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.44E-06
1.45E-06
1.46E-06
1.46E-06
1.49E-06
1.50E-06
1.51E-06
1.52E-06
1.53E-06
1.55E-06
1.57E-06
1.58E-06
1.60E-06
1.62E-06
1.65E-06
1.68E-06
1.69E-06
1.69E-06
1.72E-06
1.74E-06
1.76E-06
1.78E-06
1.78E-06
1.80E-06
1.86E-06
1.88E-06
1.90E-06
1.93E-06
1.93E-06
1.93E-06
1.97E-06
2.01E-06
2.01E-06
2.06E-06
2.08E-06
2.08E-06
2.10E-06
2.11E-06
2.11E-06
2.13E-06
2.14E-06
2.17E-06
2.17E-06
2.23E-06
2.23E-06
2.23E-06
2.25E-06
2.27E-06
2.29E-06
2.32E-06
2.38E-06
2.42E-06
2.44E-06
2.48E-06
2.51E-06
2.54E-06
2.54E-06
2.56E-06
2.61E-06
2.62E-06
2.62E-06
2.68E-06
2.70E-06
2.70E-06
2.78E-06
2.81E-06
2.84E-06
2.84E-06
2.88E-06
2.89E-06
2.94E-06
2.98E-06
3.01E-06
3.02E-06
3.05E-06
3.05E-06
3.07E-06
3.09E-06
3.09E-06
3.10E-06
3.10E-06
3.12E-06
3.12E-06
3.14E-06
3.18E-06
3.19E-06
3.20E-06
3.20E-06
3.25E-06
3.30E-06
3.33E-06
3.36E-06
3.40E-06
3.40E-06
3.45E-06
3.48E-06
3.50E-06
3.52E-06
3.55E-06
3.55E-06
3.60E-06
3.66E-06
3.67E-06
3.68E-06
3.71E-06
3.72E-06
3.72E-06
3.73E-06
3.76E-06
3.78E-06
3.79E-06
3.82E-06
3.82E-06
3.90E-06
3.91E-06
3.94E-06
3.94E-06
4.00E-06
4.00E-06
4.02E-06
4.02E-06
4.05E-06
4.06E-06
4.06E-06
4.07E-06
4.07E-06
4.10E-06
4.12E-06
4.17E-06
4.18E-06
4.19E-06
3.28E-40
1.49E-17
2.69E-17
6.82E-15
2.22E-11
8.35E-09
3.30E-07
3.79E-07
7.37E-07
3.01E-06
4.21E-06
4.21E-06
4.21E-06
4.22E-06
4.22E-06
4.23E-06
4.28E-06
4.29E-06
4.30E-06
-+-+-----++++++
-----??--+?-?++----??-----++---?-+??
-+++++++
-++--+------+-+++--??-------+
++++++-+
-+--++--+---?-++---??+-++++++
---------+-+-++++-++-+
-+--++-+
-+-+-+-+
+++-++++
+-++---+-++++++
---+---+
--++---?++++??---+-+-++++++++-+-++--+-----?+---??-------+
-+---+--+---+-+
--+--+-+
--------++-+--+
-+------+--+--+
---?+??+++++-+----++-+
---++--+
--------+++--+-+++-+?+
?++-+??+---+-++
---+++++
--+++-++
---+-+--+---??++++++++
---+---+
+++++++++++++++---+-?+
-------+
+?+++-?+
-+-----+
--+------+--+---+--+-+-++++-+
-------+++++-++
-+++++--++-++-+
-+--+--++++++++
-+------+++-+-+
--------+-+--+-+-----+
-+-+++-+
---+++-++++++?+
-++-+++---+-+++
-++-+++-?+?++++
-+++++++
-++++-+++++++++
-----+-+++-++-+
-----+-+
-+-+---------++
+--+-+-------++
?++++??++++++++
-+----+-+--+??++++++-+
+-----+--------+-+-+++
----+--+++--+-+
-------++++++++
---+---+++-++++
++++?+?+
-+-+---+
-++++-++
?--+-??-----+-+
-------+
+--++??---+---+
+-++++++
+-++++-+
+---+---+---+-+
+--+++-+
+--------+--??+
+--+++-+
------++
-+-+--+-++-++++
-------++-+--++
-------+
+-+----+
8009
8009
6325
7423
6325
8009
3013
8009
8009
8009
6325
8009
8009
8009
7782
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
8009
8009
5363
8009
8009
8009
8009
8009
8009
8009
8009
5966
8009
8009
8009
8009
8009
6552
5363
8009
8009
8009
8009
6325
8009
8009
8009
8009
6552
8009
6040
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6552
8009
8009
8009
7138
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
5363
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
8009
8009
6431
8009
8009
5363
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
6325
8009
8009
8009
8009
8009
8009
8009
8009
-3.236
3.056
-2.126
-1.751
-3.555
-2.213
-2.42
4.024
-1.777
-3.762
-3.024
-3.142
1.355
-1.747
-1.384
-0.714
3.95
-3.435
-2.048
4.026
0.757
-2.244
2.71
-3.876
3.544
-2.886
-3.66
1.458
-3.189
1.852
-2.281
-2.917
-2.493
-1.884
-3.049
-2.744
-0.774
-3.959
-0.221
-3.209
-2.212
-2.769
3.402
-2.593
-0.35
-3.496
-1.511
2.978
-0.194
3.399
-0.218
3.503
-3.676
-3.685
3.573
-3.941
4.04
3.064
-0.546
-3.421
4.236
-2.191
-4.166
-3.054
-2.56
3.246
-3.921
3.52
-0.166
1.339
-3.972
3.679
-4.141
3.559
-2.86
-2.568
-2.342
2.311
-3.348
3.435
0.372
-1.533
2.423
3.348
2.06
0.125
4.112
-3.58
3.128
-3.82
-2.788
-2.153
-1.722
-2.126
1.501
3.501
-2.712
-2.647
4.03
-0.052
-3.743
2.289
-1.226
3.582
-3.232
4.112
-3.167
3.953
3.004
-1.332
3.303
-3.054
-3.413
-0.846
-2.225
-2.39
3.221
2.939
-3.999
-0.711
1.896
-4.153
-0.648
2.308
-1.893
-3.655
2.493
-2.578
4.152
-3.581
2.354
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.21E-03
2.24E-03
3.35E-02
8.00E-02
3.78E-04
2.69E-02
1.55E-02
5.71E-05
7.56E-02
1.69E-04
2.50E-03
1.68E-03
1.75E-01
8.07E-02
1.66E-01
4.75E-01
7.81E-05
5.93E-04
4.06E-02
5.68E-05
4.49E-01
2.48E-02
6.74E-03
1.06E-04
3.94E-04
3.90E-03
2.52E-04
1.45E-01
1.43E-03
6.40E-02
2.25E-02
3.54E-03
1.27E-02
5.96E-02
2.30E-03
6.07E-03
4.39E-01
7.51E-05
8.25E-01
1.33E-03
2.70E-02
5.62E-03
6.69E-04
9.52E-03
7.27E-01
4.72E-04
1.31E-01
2.90E-03
8.46E-01
6.77E-04
8.27E-01
4.61E-04
2.37E-04
2.29E-04
3.53E-04
8.12E-05
5.33E-05
2.19E-03
5.85E-01
6.24E-04
2.27E-05
2.85E-02
3.10E-05
2.26E-03
1.05E-02
1.17E-03
8.83E-05
4.32E-04
8.68E-01
1.81E-01
7.12E-05
2.34E-04
3.46E-05
3.72E-04
4.24E-03
1.02E-02
1.92E-02
2.08E-02
8.13E-04
5.92E-04
7.10E-01
1.25E-01
1.54E-02
8.14E-04
3.94E-02
9.01E-01
3.92E-05
3.44E-04
1.76E-03
1.33E-04
5.30E-03
3.13E-02
8.51E-02
3.35E-02
1.33E-01
4.63E-04
6.68E-03
8.13E-03
5.57E-05
9.59E-01
1.82E-04
2.21E-02
2.20E-01
3.40E-04
1.23E-03
3.92E-05
1.54E-03
7.72E-05
2.66E-03
1.83E-01
9.56E-04
2.25E-03
6.43E-04
3.98E-01
2.61E-02
1.69E-02
1.28E-03
3.29E-03
6.35E-05
4.77E-01
5.79E-02
3.28E-05
5.17E-01
2.10E-02
5.83E-02
2.57E-04
1.27E-02
9.94E-03
3.30E-05
3.42E-04
1.86E-02
3671
59153
12466
46092
48656
49123
56240
14695
67092
8037
64383
49526
1494
13924
7844
50656
62096
11455
15449
32286
8683
51903
12831
32619
2804
5331
26135
12530
56625
11755
43135
3761
36014
10037
59826
22629
55928
36500
23573
42189
38638
23866
54031
26740
26570
22379
43990
3413
62846
18776
99
44003
2811
24663
60635
35368
38657
23207
9577
9456
43507
20167
62410
12265
36278
45561
55929
30891
28112
126
34020
27137
68091
12260
6755
43748
39316
25156
44585
4527
18132
38733
1064
7774
50352
20110
53313
26329
8863
24698
27385
29683
24365
49274
53311
14895
47625
40964
38433
47433
34432
66480
55075
63394
44139
48189
56779
65043
65886
52943
65258
30210
67625
24603
22522
50335
9393
45104
49394
33702
11890
1260
6364
34739
56361
24230
30142
42188
12150
48721
57705
68359
22799
2285
50043
13098
41088
64958
35890
34721
29640
14490
4056
57847
65019
31860
64297
49763
37705
41337
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
159013
5134
5663
10362
6942
56834
256281
6590
57161
6002
1352
165
10961
441024
6648
132789
3122
493911
51054
26524
157506
23315
11215
221294
8195
5816
84689
9946
23623
51277
10600
283871
2495
93622
55832
1457
2353
10436
55659
9139
5501
8892
7122
10550
55644
310
4076
64172
9051
114049
200316
203068
8453
246126
6128
223
5660
9120
1859
2357
1520
5901
23765
55623
124446
22894
9112
5431
3741
11165
79758
5576
9097
161742
262
80823
3248
23129
27246
355
10938
4001
80830
26151
79065
9908
6904
2316
54985
23522
3802
55114
84967
64430
717
90843
9183
445328
3177
4199
4068
55281
3035
127435
9044
337867
841
54431
27085
11285
79882
8365
7776
169981
2731
399818
6403
1861
10540
84266
9782
29946
10208
115727
55572
90204
10667
57198
84270
79084
9123
399823
1512
284837
115650
5571
80301
27235
203427
4495
23271
283149
139285
84938
22841
9817
7099
226
929
90853
CXorf38
PDCD2
PSEN1
HMG20B
TCF20
GPR137
NUDT14
SLPI
PELI2
RGS12
COX10
AEBP1
ERP29
MTHFD2L
SOD2
GNPDA2
HLA-DRA
PHOSPHO2
PLEKHA8P1
LATS2
RDH10
SLC9A8
AKAP11
NT5DC1
MKKS
PVALB
MS4A14
CRYZL1
RUSC1
DNAJC27
USP16
PGP
FTH1
LOC93622
CAND1
CSNK2A1
FOS
EMG1
ZNF416
CBFA2T2
PPP1CC
EIF2B2
CLDN5
ARL6IP5
OSGEP
ANXA7
CAPRIN1
OSGEPL1
PSTPIP1
WBSCR22
APOBEC3F
TUBB
CUL2
TXLNG2P
RPL6
ALDH9A1
PSAP
SLC16A6
DYRK1A
FPR1
CTSS
RAN
IL17RA
THUMPD1
TMEM219
DIS3
MTA1
POLR2B
KCNA5
NUDT3
DHRS12
PRKAR2A
USP14
SPRED1
AMD1
BHLHB9
HPGD
PLXND1
RNF115
FAS
EHD1
LMNB1
APOL6
NAT9
ATG9A
G3BP2
TBCD
FLNA
HCFC1R1
KAT6B
KIR2DL1
ARHGAP17
LSM10
PCNXL4
C2
TCEAL8
ZW10
ARHGEF35
SLC29A2
ME1
SH2D1A
TMEM140
HARS
PODN
BTAF1
UBAC2
CASP8
DNAJC10
MTBP
B4GALT7
ZC3H14
HIST1H4H
ZNF236
SPIN3
GLDC
METTL10
SELP
TOR1A
DCTN2
ALKBH7
MATR3
SERTAD3
USPL1
RASGRP4
FOXRED1
ZSWIM1
FARS2
ATP8B2
C9orf89
WDR77
SLC16A3
FOXI2
CTSH
LOC284837
TNFRSF13C
PRKAG1
PLEKHO2
COQ2
SLC25A43
MT1G
CAMSAP2
BCL9L
AMER1
ATG4C
RAB11FIP2
KEAP1
TLR4
ALDOA
CD14
SPOCD1
-+++++
---+-+--+++
++++++
-----++-+++
++++++
++++++
+-++-+
+--+++
---+----+------+
--+--+++++---+--+++++
-----+----+++--+
+-++++
++++-+
----------+----+++++++++++
-----++-+++
-------+--++-+++
+-++++
+------++------+-++-+
---++-----+---------++-+++
++--++-++++
------------+-------++++++
-----++++++
-----+
-------------?-+
---?-++++-+
+-++-+
--+--++++++
++++-+
-----+++--+
--+--++++-+
--+--------------+--+
+-++++
++-+++
++-+-+
----++-++++
--+---------+--+++-++
++-+++
++++-+
++-+++
++++++
++++++
-----++-?++
-----++--++
++-+++
++++++
-+---+++-++
-----+
-+++++
-----++++++
-------------------------+----++++-+
-----++-+++
--------?-+-++++
--+---+--------+
------+++++
-----------------+--+++++++++-+
++-+++
---+---+--++++++
--+--+++?++
-----+
------+---+----++-+++
-----++++++
++-+++
++++-+
++++-+
------+++++
++++++
++++++
+--+++
++++++
-------------+-+
-------+--++-+-+
++++-+
++++++
++++-+
++++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
4.596
-4.595
4.594
4.594
-4.593
4.593
4.592
4.592
4.592
4.592
-4.59
-4.588
-4.588
-4.587
4.587
-4.587
4.587
-4.586
-4.586
4.584
4.582
4.581
-4.579
-4.576
-4.576
4.574
4.57
-4.568
4.568
-4.565
-4.565
4.564
4.562
-4.561
-4.558
-4.556
4.556
-4.554
-4.553
-4.552
-4.551
4.548
4.548
4.545
-4.544
-4.543
-4.542
-4.542
4.542
-4.541
4.539
-4.539
-4.537
-4.537
-4.535
-4.534
4.534
4.534
-4.534
4.533
4.532
-4.532
4.531
-4.531
4.529
-4.528
-4.528
-4.528
-4.527
4.526
4.525
4.524
-4.523
4.522
-4.522
-4.52
-4.52
4.52
4.518
4.515
4.514
4.513
4.512
-4.512
4.511
-4.511
4.51
4.509
4.508
-4.507
4.501
-4.499
4.499
-4.499
4.498
-4.497
-4.497
-4.496
-4.496
-4.496
-4.494
4.494
-4.49
4.49
-4.49
-4.489
4.489
-4.487
-4.486
-4.485
-4.484
4.483
-4.483
-4.482
-4.482
-4.48
4.478
4.477
4.477
-4.476
-4.475
4.475
-4.475
4.474
-4.473
-4.473
-4.473
-4.472
4.472
-4.471
4.471
4.47
4.469
4.468
-4.468
4.467
4.467
4.465
4.465
4.464
-4.464
-4.464
-4.463
-4.462
-4.461
4.461
4.46
4.459
4.459
4.456
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4.31E-06
4.34E-06
4.35E-06
4.36E-06
4.37E-06
4.37E-06
4.39E-06
4.39E-06
4.39E-06
4.40E-06
4.43E-06
4.47E-06
4.48E-06
4.49E-06
4.49E-06
4.50E-06
4.50E-06
4.51E-06
4.51E-06
4.57E-06
4.61E-06
4.63E-06
4.68E-06
4.74E-06
4.74E-06
4.78E-06
4.89E-06
4.93E-06
4.93E-06
4.99E-06
4.99E-06
5.02E-06
5.06E-06
5.08E-06
5.17E-06
5.21E-06
5.21E-06
5.27E-06
5.29E-06
5.31E-06
5.35E-06
5.42E-06
5.42E-06
5.50E-06
5.52E-06
5.54E-06
5.57E-06
5.57E-06
5.58E-06
5.60E-06
5.64E-06
5.66E-06
5.70E-06
5.70E-06
5.77E-06
5.78E-06
5.79E-06
5.80E-06
5.80E-06
5.83E-06
5.83E-06
5.84E-06
5.88E-06
5.88E-06
5.92E-06
5.95E-06
5.95E-06
5.96E-06
5.99E-06
6.02E-06
6.03E-06
6.06E-06
6.08E-06
6.12E-06
6.13E-06
6.18E-06
6.19E-06
6.20E-06
6.24E-06
6.32E-06
6.36E-06
6.40E-06
6.41E-06
6.44E-06
6.44E-06
6.45E-06
6.48E-06
6.53E-06
6.55E-06
6.57E-06
6.78E-06
6.82E-06
6.84E-06
6.84E-06
6.87E-06
6.90E-06
6.91E-06
6.92E-06
6.93E-06
6.94E-06
6.99E-06
7.01E-06
7.11E-06
7.13E-06
7.13E-06
7.14E-06
7.16E-06
7.24E-06
7.26E-06
7.29E-06
7.31E-06
7.36E-06
7.36E-06
7.38E-06
7.38E-06
7.48E-06
7.55E-06
7.57E-06
7.58E-06
7.59E-06
7.64E-06
7.65E-06
7.65E-06
7.68E-06
7.70E-06
7.71E-06
7.72E-06
7.74E-06
7.75E-06
7.78E-06
7.78E-06
7.83E-06
7.84E-06
7.90E-06
7.91E-06
7.94E-06
7.95E-06
8.00E-06
8.02E-06
8.05E-06
8.06E-06
8.06E-06
8.09E-06
8.11E-06
8.16E-06
8.17E-06
8.21E-06
8.22E-06
8.25E-06
8.36E-06
4080
39447
60881
19097
35231
14
47524
27906
43914
40694
23673
24951
21831
21681
11335
28652
66811
62696
18128
51823
11603
60339
44369
42768
59861
59923
29007
23402
45632
56729
25433
59303
36447
2426
52031
12599
10268
45843
30827
19233
24840
54167
36309
3946
29590
65122
61608
5357
37878
48295
31267
19164
45351
32045
11436
33316
15978
55647
13323
8395
66015
37929
25145
6581
40797
31020
28982
40769
27247
58292
24666
42352
29433
23295
15541
46392
7093
66473
4830
36482
61050
22646
42707
23915
7622
64781
49036
41572
36512
16123
24865
59400
50004
51433
67604
55965
4687
14913
64682
21664
55013
64051
42112
33999
41122
41934
22176
55856
20589
49638
58572
58308
42582
16138
28894
37180
37979
12123
44148
1165
67759
52982
19341
31045
45067
58008
53521
37952
2352
4680
65088
33651
8949
25771
11491
33305
62140
12884
54973
57264
30349
66917
29823
38967
21524
62124
54409
11465
45126
32556
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
776
57730
501
9482
8545
7358
3557
2806
9184
4134
4176
51116
144233
260294
8864
60488
221322
116461
83548
7270
9330
150771
6209
64342
23394
81887
22863
29933
23528
9202
113612
8825
1476
84795
6873
65018
7982
5476
8739
5598
284443
8425
7326
8826
51226
5994
27043
51279
55784
6717
8932
10581
9791
1102
56683
4931
64598
26271
65108
5781
91010
79035
5423
97
896
160364
29078
80304
8065
59349
84320
29903
85329
286826
285761
1032
79876
221443
170958
10067
22933
1499
23368
9061
474344
5168
9922
57060
3936
65110
2926
253959
130589
113
54899
498
11009
9498
23352
286046
64417
91543
56910
26112
710
115992
57647
10410
127253
9643
83448
8721
28955
3553
55847
31
150275
55609
206358
6152
57097
338692
317
5214
777
140469
26228
64072
83596
10313
9487
83595
56993
152559
123811
83852
2975
10439
9545
80146
3811
132864
5830
81855
80273
26127
80021
63826
2591
10464
CACNA1D
ANKRD36B
ALDH7A1
STX8
CGGBP1
UGDH
IL1RN
GOT2
BUB3
MAP4
MCM7
MRPS2
BCDIN3D
NSUN5P2
PER2
MRPS35
TBC1D32
TSEN15
COG3
TTF1
GTF3C3
ITPRIPL1
RPS15
HS1BP3
ADNP
LAS1L
ATG14
GPR132
ZNF281
ZMYM4
CYP2U1
LIN7A
CSTB
PYROXD2
TAF2
PINK1
ST7
CTSA
HRK
MAPK7
ZNF493
LTBP4
UBE2G1
IQGAP1
COPZ2
RFXAP
PELP1
C1RL
MCTP2
SRI
MBD2
IFITM2
PTDSS1
RCBTB2
C21orf59
NVL
MOSPD3
FBXO5
MARCKSL1
PTPN11
FMNL3
NABP2
POLB
ACYP1
CCND3
CLEC12A
NDUFAF4
C2orf44
CUL5
KLHL12
ACBD6
CCDC106
LGALS12
LIN9
DCBLD1
CDKN2D
UBA5
OARD1
ZNF525
SCAMP3
SIRT2
CTNNB1
PPP1R13B
PAPSS1
GIMAP6
ENPP2
IQSEC1
PCBP4
LCP1
UPF3A
GRSF1
RALGAPA1
GALM
ADCY7
PXK
ATP5A1
IL24
SLC4A8
UBR4
XKR6
C5orf28
RSAD2
STARD7
CCDC69
SERPING1
RNF166
DHX37
IFITM3
TYW3
MORF4L2
PUS7L
EDF1
DEXI
IL1B
CISD1
ACACA
CCDC117
ZNF280C
SLC36A1
RPL24
PARP11
ANKRD13D
APAF1
PFKP
CACNA1E
MYO3B
STAP1
CDH23
BCL2L12
RTN3
PIGL
SOX7
TOMM22
PAQR3
FOPNL
SETDB2
GTF3C1
OLFM1
RAB3D
UXS1
KIR3DL1
CPEB2
PEX5
SFXN3
GRPEL1
FGFR1OP2
TMEM62
SRR
GALNT3
PIBF1
+++-++
+---------++++-+
-------+--++++++
-----+
-----+-+?-+
----------+
----------+
-----+
--+---++--------------+-------++-+++
-----+
++++-+
--+---------+--++-+++
++++++
----------++++-+
++++++
++-+++
-----++++++
++++++
+++-++
++++++
++++++
--+--++--++
--+--+-++++
+-+-++
---++-----++++-+
+++?++
++-+++
++++++
++++++
-----+
+-++-+
---?------++-+++
--+-----------------++-+++
++++++
+----++-+++
-+++++
------------+--+-+?++
----------+
++++-+
-----++++++
++-++---------+----------++++-+
++++++
---?-++++++
--------+-++++-+
++-+++
++++-+
+--------------++-+++
++-+-+
-+++++
-----+
---+-++-+++
++++++
-------+--++++++
-+++-+
++++++
++++-+
++++-+
-----+
++++++
-------+-+----------+
-----+-+-----+-+---------+----+-++-+
---+------++++++
+++?-+
++-+++
+-+-++
+++--+
--+--+++-++
--+--++++++
++-?-------------+-------+-+--++-+++
++++++
+-++++
-++-+++++++-++++
-----+
++++++
---?-+
+-+--++++++
-----+++-++
-++---
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
4.454
-4.453
-4.452
4.451
-4.451
-4.449
4.448
-4.448
-4.447
4.446
-4.446
-4.446
-4.445
-4.443
-4.443
-4.443
-4.443
-4.442
-4.441
-4.44
-4.436
4.433
-4.431
4.43
-4.428
-4.427
-4.426
4.426
4.424
-4.424
-4.424
4.424
4.424
4.423
-4.422
4.421
4.419
4.419
4.419
4.415
-4.414
4.414
-4.412
4.411
4.411
-4.411
-4.409
4.408
4.407
4.407
4.407
4.406
-4.403
4.403
-4.4
-4.4
4.4
-4.399
-4.398
-4.396
-4.395
4.394
4.391
-4.39
4.39
4.389
-4.387
-4.387
-4.386
4.386
-4.384
-4.382
4.382
-4.379
4.377
4.376
-4.376
-4.375
-4.375
-4.375
4.373
4.371
-4.37
4.37
-4.368
-4.368
4.367
4.366
4.365
-4.363
-4.363
-4.362
4.361
4.36
4.359
-4.359
-4.358
4.358
4.357
-4.357
-4.357
4.356
4.355
4.352
4.352
4.35
-4.35
4.35
-4.349
-4.348
-4.345
-4.345
-4.344
-4.344
-4.343
-4.342
-4.342
-4.34
4.339
-4.338
-4.337
4.336
4.335
4.333
4.333
4.33
-4.326
4.326
-4.326
4.325
-4.325
-4.322
-4.321
-4.322
-4.32
-4.32
4.319
4.318
4.318
-4.317
4.317
4.317
-4.317
4.316
-4.316
-4.315
4.315
-4.315
4.314
-4.314
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
8.43E-06
8.46E-06
8.52E-06
8.54E-06
8.56E-06
8.62E-06
8.67E-06
8.69E-06
8.72E-06
8.74E-06
8.75E-06
8.76E-06
8.80E-06
8.85E-06
8.86E-06
8.86E-06
8.87E-06
8.89E-06
8.94E-06
9.01E-06
9.14E-06
9.29E-06
9.38E-06
9.44E-06
9.50E-06
9.57E-06
9.59E-06
9.60E-06
9.69E-06
9.69E-06
9.69E-06
9.70E-06
9.71E-06
9.74E-06
9.76E-06
9.82E-06
9.89E-06
9.90E-06
9.93E-06
1.01E-05
1.01E-05
1.02E-05
1.03E-05
1.03E-05
1.03E-05
1.03E-05
1.04E-05
1.04E-05
1.05E-05
1.05E-05
1.05E-05
1.05E-05
1.07E-05
1.07E-05
1.08E-05
1.08E-05
1.08E-05
1.09E-05
1.09E-05
1.11E-05
1.11E-05
1.11E-05
1.13E-05
1.13E-05
1.13E-05
1.14E-05
1.15E-05
1.15E-05
1.16E-05
1.16E-05
1.17E-05
1.18E-05
1.18E-05
1.20E-05
1.20E-05
1.21E-05
1.21E-05
1.22E-05
1.22E-05
1.22E-05
1.23E-05
1.24E-05
1.24E-05
1.25E-05
1.25E-05
1.26E-05
1.26E-05
1.27E-05
1.27E-05
1.28E-05
1.28E-05
1.29E-05
1.30E-05
1.30E-05
1.31E-05
1.31E-05
1.31E-05
1.32E-05
1.32E-05
1.32E-05
1.32E-05
1.33E-05
1.33E-05
1.35E-05
1.35E-05
1.36E-05
1.36E-05
1.36E-05
1.37E-05
1.38E-05
1.39E-05
1.39E-05
1.40E-05
1.40E-05
1.40E-05
1.42E-05
1.42E-05
1.43E-05
1.43E-05
1.44E-05
1.44E-05
1.45E-05
1.46E-05
1.47E-05
1.47E-05
1.49E-05
1.52E-05
1.52E-05
1.52E-05
1.52E-05
1.53E-05
1.54E-05
1.55E-05
1.55E-05
1.56E-05
1.56E-05
1.57E-05
1.57E-05
1.58E-05
1.58E-05
1.58E-05
1.58E-05
1.59E-05
1.59E-05
1.59E-05
1.60E-05
1.60E-05
1.60E-05
1.60E-05
1.60E-05
63154
60068
44777
129
58800
28792
4479
48057
5375
20809
67522
35601
15654
54196
29098
57068
15357
58032
423
60457
44519
21033
23479
19637
27640
12759
26721
40751
53885
3434
55964
47743
13986
62186
47347
46989
66375
5713
31215
41401
39292
64391
36900
37207
47477
42502
35744
66715
30332
17780
19178
58932
19825
9774
23409
7586
11481
14192
55776
3073
14900
55621
68264
46111
65807
554
41084
38677
31659
52763
52220
53876
22592
39273
23615
51049
9572
65022
1095
47050
8420
2561
58578
17929
43305
2971
19739
16746
19273
17063
1111
16966
30952
32429
33258
45764
52174
57122
21750
62084
43662
66086
24410
18723
4211
11825
45827
46141
26148
4455
62652
36698
6615
14581
50605
50511
18902
54956
29143
41570
26208
22581
27154
29973
67576
3994
18369
20864
39709
12833
9191
52013
17098
7497
23604
50012
32929
58313
21610
63234
4147
39349
53195
52000
49362
33021
62871
28779
2148
66776
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
55316
23136
84081
230
1027
4926
23673
6515
23582
6892
54989
8924
8507
8743
23301
147138
8682
6539
51593
1212
64418
388115
6041
3705
79666
400
54960
11021
10616
10998
55861
200403
54014
1174
961
153241
8675
1351
84861
7334
55422
10748
8518
166
11342
140803
90637
8738
9361
6731
79089
822
340205
2934
6923
51063
8602
91
103910
829
79191
94104
91442
30009
25929
63027
257218
29978
6580
119774
59342
2322
10522
60685
124044
80213
9469
23102
221914
51281
911
63874
8434
5936
949
83658
3915
10146
3993
51309
644314
55332
6296
405
8607
10210
1977
23607
10397
56888
10001
51734
101
11314
128854
7533
25871
64210
2214
55144
3359
112611
9744
7033
54935
134147
94274
202018
51411
8539
6374
53827
21
81873
8273
10042
150684
4258
4035
9577
10241
23117
1820
6510
1612
5889
23403
4047
10556
8277
55218
714
139231
6419
3134
1745
79930
9031
26046
30851
RSAD1
EPB41L3
NSRP1
ALDOC
CDKN1B
NUMA1
STX12
SLC2A3
CCNDBP1
TAPBP
ZNF770
HERC2
ENC1
TNFSF10
EHBP1
TMC8
PEA15
SLC6A12
SRRT
CLTB
TMEM168
C15orf52
RNASEL
ITPK1
PLEKHF2
ARL1
GEMIN8
RAB35
RBCK1
SLC27A5
DBNDD2
VWA3B
BRWD1
AP1S1
CD47
CEP120
STX16
COX8A
KLHL22
UBE2N
ZNF331
KLRAP1
IKBKAP
AES
RNF13
TRPM6
ZFAND2A
CRADD
LONP1
SRP72
TMUB2
CAPG
TREML1
GSN
TCEB2
CALHM2
NOP14
ACVR1B
MYL12B
CAPZA1
IRX3
PAXBP1
C19orf40
TBX21
GEMIN5
SLC22A23
SHPRH
UBQLN2
SLC22A1
OR52K2
SCPEP1
FLT3
DEAF1
ZFAND3
SPATA2L
TM2D3
CHST3
TBC1D2B
GPC2
ANKMY1
CD1C
ABHD4
RECK
RBM4
SCARB1
DYNLRB1
LAMC1
G3BP1
LLGL2
ARMCX1
MTE
DRAM1
ACSM3
ARNT
RUVBL1
TOPORS
EIF4E
CD2AP
NDRG1
KCMF1
MED6
MSRB1
ADAM8
CD300A
TSPY26P
YWHAH
C3orf17
MMS19
FCGR3A
LRRC8D
HTR3A
RWDD2A
ACAP1
TFF3
DUSP23
CMBL
PPP1R14A
TAPT1
BIN2
API5
CXCL5
FXYD5
ABCA3
ARPC5L
SLC10A3
HMGXB4
COMMD1
MGST2
LRP1
BRE
CALCOCO2
NPIPB4
ARID3A
SLC1A5
DAPK1
RAD51C
FBXO46
LSS
RPP30
TKTL1
EXD2
C1QC
FAM199X
SETMAR
HLA-F
DLX1
DOK3
BAZ1B
LTN1
TAX1BP3
-----+-++++
---------++
--+-+-----++++-+
++++++
+++++++++-+
----------+
+++?++
++++++
+-----+---+--+++
++++++
-----+
++-+++
--+--+++-++
+-++-+
++++-+
--+------------++++++
++++-+
-----++++++
++++++
--+-+++++++
-----+-+-------+
-+-+++
--------+------++-+++
----------++++++
+-+--+-++++
+-++++
-------+--++++++
++++-+
++-+++++-++
++-+++
++++-+
-----+-++++
++++++
+-++++
+++-++
-----++++++
--+--+
-----+-----------+--++++++
++++++
--++++
-+++-+
-----+
++++++
++++-+
--+--+++-++
++++-+
-----+
++-?++
-----++++++
--------+------++++++
----------+++--+
--+--+
++++++
+++++-------++-+
---?---+---------+--+++-++
++++++
--+--++++-+
+++--+
++++-+
-----++-++----------+
++-+++
----------+
----------++++++
-+++++
++++++
----+--+--++++-+
---+-+++++-----++-+++
++-+++
+++-++
++++++
++-+++
--++-+
++++-+
-+-+++
++++++
-----++++-+
++++++
+-++++
----------+
++-+++
+----++-+++
-----+
++++++
+-+-++
------+++++
++++++
++++++
-+-----+--+++-++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-4.313
4.313
-4.311
-4.31
-4.31
-4.309
4.309
4.308
4.308
4.306
-4.305
-4.304
4.303
4.301
-4.3
-4.299
4.296
4.296
-4.296
4.296
-4.295
4.294
4.294
4.293
-4.291
-4.291
-4.29
4.289
4.289
-4.289
4.288
4.284
-4.283
4.283
-4.283
-4.282
-4.282
4.281
-4.279
-4.279
-4.276
4.272
-4.271
-4.271
4.27
-4.27
4.269
4.269
-4.267
-4.267
4.267
4.266
4.264
4.264
4.263
4.262
-4.261
4.261
4.259
4.257
4.257
-4.255
4.255
4.254
-4.254
-4.251
-4.25
-4.249
4.248
4.248
4.247
4.246
-4.245
4.244
4.243
-4.241
4.24
4.24
-4.24
4.239
-4.239
4.237
-4.237
-4.237
-4.236
4.236
-4.235
-4.235
4.233
-4.232
4.232
4.232
-4.231
4.231
-4.229
-4.228
-4.226
-4.226
4.226
4.225
-4.224
4.223
4.222
4.222
-4.222
4.22
-4.22
-4.22
4.219
-4.218
-4.218
-4.215
-4.215
4.214
4.214
4.21
-4.209
-4.209
4.208
-4.208
4.205
-4.205
4.205
4.203
4.203
4.203
4.203
4.203
4.199
4.198
4.198
-4.197
4.196
4.195
4.195
-4.194
-4.194
4.191
-4.19
4.19
-4.188
4.188
4.187
-4.187
4.183
4.182
4.182
-4.182
-4.181
4.181
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.61E-05
1.61E-05
1.63E-05
1.63E-05
1.64E-05
1.64E-05
1.64E-05
1.64E-05
1.65E-05
1.67E-05
1.67E-05
1.68E-05
1.68E-05
1.70E-05
1.71E-05
1.72E-05
1.74E-05
1.74E-05
1.74E-05
1.74E-05
1.74E-05
1.75E-05
1.75E-05
1.77E-05
1.78E-05
1.78E-05
1.79E-05
1.79E-05
1.80E-05
1.80E-05
1.80E-05
1.84E-05
1.84E-05
1.84E-05
1.85E-05
1.85E-05
1.85E-05
1.86E-05
1.88E-05
1.88E-05
1.91E-05
1.93E-05
1.95E-05
1.95E-05
1.95E-05
1.96E-05
1.96E-05
1.97E-05
1.98E-05
1.98E-05
1.98E-05
1.99E-05
2.01E-05
2.01E-05
2.02E-05
2.02E-05
2.04E-05
2.04E-05
2.06E-05
2.07E-05
2.07E-05
2.09E-05
2.09E-05
2.10E-05
2.10E-05
2.13E-05
2.14E-05
2.15E-05
2.15E-05
2.16E-05
2.17E-05
2.18E-05
2.19E-05
2.20E-05
2.21E-05
2.22E-05
2.23E-05
2.24E-05
2.24E-05
2.25E-05
2.25E-05
2.26E-05
2.26E-05
2.27E-05
2.27E-05
2.28E-05
2.28E-05
2.29E-05
2.30E-05
2.32E-05
2.32E-05
2.32E-05
2.33E-05
2.33E-05
2.35E-05
2.35E-05
2.38E-05
2.38E-05
2.38E-05
2.39E-05
2.40E-05
2.41E-05
2.42E-05
2.42E-05
2.43E-05
2.44E-05
2.44E-05
2.45E-05
2.45E-05
2.47E-05
2.47E-05
2.50E-05
2.50E-05
2.51E-05
2.51E-05
2.55E-05
2.56E-05
2.57E-05
2.58E-05
2.58E-05
2.61E-05
2.61E-05
2.62E-05
2.63E-05
2.63E-05
2.63E-05
2.63E-05
2.64E-05
2.68E-05
2.69E-05
2.69E-05
2.71E-05
2.72E-05
2.73E-05
2.73E-05
2.74E-05
2.74E-05
2.78E-05
2.79E-05
2.79E-05
2.82E-05
2.82E-05
2.82E-05
2.82E-05
2.88E-05
2.88E-05
2.89E-05
2.89E-05
2.90E-05
2.90E-05
1549
18478
36567
13902
39729
5949
46114
38742
67632
16116
1308
33980
42044
32994
12531
63223
43931
63702
64534
44607
28673
39719
61896
22043
38352
37560
38165
26961
2200
12824
42171
66088
13441
41044
33277
11758
61445
15879
51387
51347
15221
2995
60101
67297
55184
21584
48505
63934
44760
44318
22870
63848
2771
37318
14772
40105
6248
47758
58082
50164
7733
1035
11027
17582
62060
2039
33230
40579
14352
5590
30280
14714
49892
19524
1727
10378
3833
4753
35211
22668
10229
35161
29194
43060
16965
34518
48095
23103
42756
4933
35443
39561
12961
40915
494
10330
59690
16418
33352
28843
47568
25885
39899
4689
12334
47203
26414
7543
25680
14051
817
54011
47067
2699
32630
48586
39769
33604
37602
26796
40010
58936
701
55566
52516
62924
7797
61975
55980
26828
34856
38027
61034
46921
47557
61434
15251
59846
26218
51807
3084
3
36793
24820
10848
19792
55117
16720
30356
60475
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
9975
54407
7464
80019
8875
1145
9832
25974
222658
8989
10772
3217
4862
80035
89795
3295
9855
3843
114625
10695
10651
10771
2010
6810
23428
9338
4257
64397
54471
55127
8491
10743
51291
54902
85415
8801
81609
79796
29803
55333
26000
6687
80194
196463
4057
284309
1911
51562
60436
26578
283643
23332
199704
80003
1203
57463
160335
7148
23598
11025
55246
80258
137964
29780
84236
23061
51246
51126
22876
23116
91947
54984
3480
51062
9130
6692
64432
26191
3603
7681
6015
2178
2744
22907
114799
2533
10634
5437
83698
2060
11056
222166
55769
1471
4688
9360
10516
10900
83877
3003
51167
113451
8178
56931
11147
9045
127733
145748
9126
55898
84056
100129828
164
4848
6811
131566
10643
3371
8550
23051
3480
5721
348995
79650
91663
9510
100129828
79892
57617
493753
5352
81931
54532
57002
56833
84314
10333
80755
55041
5905
730094
8458
146691
8673
1540
79066
25842
27034
22909
11322
NR1D2
SLC38A2
CORO2A
UBTD1
VNN2
CHRNE
JAKMIP2
MMACHC
KCTD20
TRPA1
SRSF10
HOXB7
NPAS2
ANP32A-IT1
NAV3
HSD17B4
FARP2
IPO5
ERMAP
CNPY3
MTX2
ZMYND11
EMD
STX4
SLC7A8
TCEAL1
MGST1
ZNF106
SMCR7L
HEATR1
MAP4K3
RAI1
GMIP
TTC19
RHPN2
SUCLG2
SNX27
ALG9
REPIN1
SYNJ2BP
TBC1D10B
SPG7
TMEM134
PLBD2
LTF
ZNF776
PHC1
MBIP
TGIF2
OSTF1
C14orf80
CLASP1
ZNF585A
PCNXL2
CLN5
AMIGO1
TMTC2
TNXB
PATZ1
LILRB3
CCDC25
EFHC2
AGPAT6
PARVB
RHBDD1
TBC1D9B
SHISA5
NAA20
INPP5F
FAM179B
ARRDC4
PINX1
IGF1R
ATL1
FAM50A
SPINT1
MRPS25
PTPN22
IL16
MKRN3
RING1
FANCE
GLS
DHX30
ESCO1
FYB
GAS2L1
POLR2H
CALN1
EPS15
DDX52
C7orf41
ZNF83
CST3
NCF2
PPIG
FBLN5
RUNDC3A
TM2D2
GZMK
CYB5R4
ADC
ELL
DUS3L
HHLA3
RPL14
UBXN10
LYSMD4
SMC3
UNC45A
KATNAL1
RFX7
AP1G1
CNOT2
STX5
DCBLD2
IGF2BP3
TNC
MAPKAPK5
ZHX3
IGF1R
PSME2
NUP43
USB1
MYADM
ADAMTS1
IVNS1ABP
MCMBP
VPS18
COA5
PLOD2
ZNF93
USP53
YAE1D1
SLAMF8
TMEM107
TLR6
AARSD1
PLEKHB2
RANGAP1
C16orf52
TTF2
TOM1L2
VAMP8
CYLD
METTL16
ASF1A
ACAD8
FAN1
TMC6
-+-----+--++++++
+++?++
+-++++
-+++++
++++++
-----+
++++-+
++-+++
---+-++-+++
--+--+++--+
-+++-+
++++-+
-+-?++
-----++++++
-+++++
--+--+----+----++-+++
---+-----+++++++
++++-+
-----+
---?---+-------+++--+
----+-----+
--++-++++-+
---+------+
-----++++++
-----+
-----++++++
++-+++
--+--+------------?-++++++
++--++
++-+++
------------++----+---++++
++++++
-----++++++
----++-+---+++++
++-++-+---++-+++
++++-+
---+-+++-++
--+--+-++++
---+----+-++++++
++-+++
-+++-+
-----+-++-+
-------------+------+---------+
--+----+--+++-++
-----++++++
+-+--+
--+--++++++-+--++++-+
++++-+
--+-------+
++-++-----+---++-++++
-----++++++
-----+
-------+--++++++
-----+
+--?-++-+++
++-+++
-----++++++
------+++++
--+?-++++++-+-++
------------+---+++++
-----+++-++
++++-+
+-+?++
++++++
+-+--+
++-?++
-----++++++++++---+------++++-+
+-+?++
++++++
-----+
-+-+++
--------+------+-+?++
++-+++
++--+-+--------+-++++
-----------
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
-4.181
-4.18
4.179
4.179
4.178
4.178
4.178
-4.178
4.177
4.176
-4.176
4.175
-4.174
4.173
4.172
4.171
4.171
-4.17
4.168
4.168
-4.167
-4.166
-4.166
4.165
-4.165
-4.164
4.162
4.162
-4.161
-4.16
-4.159
-4.159
4.159
-4.159
-4.158
-4.158
4.157
-4.156
-4.156
-4.155
4.155
-4.155
-4.154
4.154
4.153
-4.152
-4.151
-4.15
-4.149
4.148
4.145
4.145
-4.145
-4.145
-4.144
-4.144
4.139
4.139
-4.139
4.138
-4.137
-4.135
4.135
4.134
-4.134
4.134
4.134
-4.134
4.133
-4.133
4.13
-4.13
-4.128
4.127
4.125
4.125
-4.123
4.122
-4.12
-4.119
-4.116
-4.116
-4.116
-4.113
-4.113
-4.111
4.11
-4.11
4.11
4.11
-4.107
4.107
-4.106
4.105
4.104
-4.103
-4.102
4.102
-4.1
-4.1
4.099
-4.099
4.098
-4.096
-4.095
-4.095
4.095
-4.093
-4.093
4.091
4.087
-4.086
4.086
-4.085
4.085
-4.084
4.084
4.084
-4.081
-4.081
-4.079
4.077
-4.077
4.077
4.077
4.076
4.075
4.075
4.075
-4.074
4.074
4.074
-4.074
-4.073
4.072
4.071
4.07
-4.07
4.067
-4.067
-4.067
-4.066
4.063
4.062
-4.061
-4.061
-4.061
4.06
-4.06
-4.06
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.90E-05
2.92E-05
2.93E-05
2.93E-05
2.94E-05
2.94E-05
2.95E-05
2.95E-05
2.96E-05
2.97E-05
2.97E-05
2.98E-05
2.99E-05
3.01E-05
3.02E-05
3.03E-05
3.03E-05
3.04E-05
3.07E-05
3.08E-05
3.09E-05
3.10E-05
3.11E-05
3.11E-05
3.11E-05
3.13E-05
3.16E-05
3.16E-05
3.17E-05
3.19E-05
3.19E-05
3.19E-05
3.20E-05
3.20E-05
3.21E-05
3.22E-05
3.23E-05
3.24E-05
3.24E-05
3.25E-05
3.25E-05
3.26E-05
3.27E-05
3.27E-05
3.28E-05
3.29E-05
3.31E-05
3.33E-05
3.35E-05
3.36E-05
3.39E-05
3.40E-05
3.40E-05
3.40E-05
3.41E-05
3.41E-05
3.48E-05
3.49E-05
3.49E-05
3.50E-05
3.52E-05
3.55E-05
3.56E-05
3.57E-05
3.57E-05
3.57E-05
3.57E-05
3.57E-05
3.58E-05
3.59E-05
3.63E-05
3.63E-05
3.67E-05
3.67E-05
3.70E-05
3.71E-05
3.75E-05
3.75E-05
3.80E-05
3.81E-05
3.86E-05
3.86E-05
3.86E-05
3.90E-05
3.90E-05
3.93E-05
3.95E-05
3.96E-05
3.96E-05
3.96E-05
4.01E-05
4.02E-05
4.03E-05
4.05E-05
4.07E-05
4.08E-05
4.09E-05
4.10E-05
4.13E-05
4.14E-05
4.14E-05
4.15E-05
4.17E-05
4.20E-05
4.22E-05
4.22E-05
4.23E-05
4.26E-05
4.27E-05
4.30E-05
4.37E-05
4.38E-05
4.40E-05
4.40E-05
4.41E-05
4.42E-05
4.42E-05
4.43E-05
4.48E-05
4.49E-05
4.52E-05
4.56E-05
4.57E-05
4.57E-05
4.57E-05
4.58E-05
4.60E-05
4.60E-05
4.61E-05
4.62E-05
4.62E-05
4.63E-05
4.63E-05
4.64E-05
4.67E-05
4.68E-05
4.71E-05
4.71E-05
4.76E-05
4.76E-05
4.76E-05
4.79E-05
4.84E-05
4.87E-05
4.88E-05
4.89E-05
4.89E-05
4.91E-05
4.91E-05
4.91E-05
27164
54294
4773
16206
30616
16333
59927
32925
39552
61300
61941
61237
21593
61623
66845
47671
42635
57565
18430
64181
13778
45954
27307
6329
7982
13156
66771
37707
30259
49426
6263
10437
36733
35092
44964
26460
24402
14501
39491
11239
18022
18330
54622
44412
65964
45700
4989
29765
9098
55708
39566
51321
3613
67014
57358
60436
14577
5943
46935
2227
25028
30653
52660
1352
24252
25779
39191
45731
62069
34476
23577
32632
35278
51299
35943
1993
51145
25391
58328
3196
31234
64064
11533
11429
24483
50278
14739
30470
33069
63014
45642
45495
21702
5761
64352
54296
45165
60094
26048
35738
40070
31442
46521
39164
36709
28126
31618
2086
38477
21481
50869
41412
35107
58986
20770
58942
913
16141
27221
28611
38271
43420
16636
41896
52204
27389
59719
63533
48474
592
47397
24744
45385
7072
64484
60207
24751
47591
53269
37647
28128
2046
51303
63055
9023
49130
65681
64211
61952
1506
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
119710
10314
51497
80335
84456
7511
2296
56672
10735
7476
60485
11022
28996
5829
56882
81622
10452
4277
5607
84179
2639
7347
8904
3952
93058
79671
9019
55274
23762
283489
2005
2889
10060
51026
57584
202309
28956
10645
1063
373
5690
7884
5634
80209
255967
10283
121536
56254
80270
9049
200315
374882
157983
718
129787
8567
36
9026
55303
239
11011
55746
27309
79080
51266
63916
5236
5691
120103
79657
79901
22803
113540
57418
54865
57403
6693
3556
64859
55080
54148
151188
64215
390036
79665
8803
90592
55186
9924
4678
10175
7565
5745
55578
10657
1643
9249
284757
7764
8239
9826
7172
8050
54806
3454
152006
2730
9896
353322
54606
51373
4905
9632
57590
81553
55000
163859
196549
928
84678
2197
85465
57048
57555
144363
5110
55954
115361
55654
29957
10465
246
4891
839
6165
114928
114932
221037
55749
5747
55125
10966
2548
644
220388
23048
79672
1523
55437
10910
C11orf74
LANCL1
NELFCD
WDR82
L3MBTL3
XPNPEP1
FOXC1
AKIP1
STAG2
WNT7A
SAV1
TDRKH
HIPK2
PXN
CDC42SE1
UNC93B1
TOMM40
MICB
MAP2K5
MFSD7
GCDH
UCHL3
CPNE1
LEP
COQ10A
NLRX1
MPZL1
PHF10
OSBP2
CHAMP1
ELK4
RAPGEF1
ABCC9
GOLT1B
ARHGAP21
GAPT
LAMTOR2
CAMKK2
CENPF
TRIM23
PSMB2
SLBP
PRPS2
PROSER1
PAN3
CWC27
AEBP2
RNF20
HSD3B7
AIP
APOBEC3A
TMEM205
C9orf66
C3
TMEM18
MADD
ACADSB
HIP1R
GIMAP4
ALOX12
TLK2
NUP133
ZNF330
CCDC86
CLEC1B
ELMO2
PGM1
PSMB3
SLC36A4
RPAP3
CYBRD1
XRN2
CMTM1
WDR18
GPATCH4
RAB22A
SPN
IL1RAP
NABP1
TAPBPL
MRPL39
ARL6IP6
DNAJC1
OR52K1
DHX40
SUCLA2
ZNF700
SLC25A36
PAN2
NASP
CNIH
ZNF17
PTH1R
SUPT20H
KHDRBS1
DDB2
DHRS3
RP5-1043L13.1
ZNF217
USP9X
ARHGEF11
TPMT
PDHX
AHI1
IFNAR1
RNF38
GCLM
FIG4
ANKRD37
DDX56
MRPS17
NSF
SEC24C
WDFY1
FAM49A
TUG1
SDE2
EEF1DP3
CD9
KDM2B
FAU
EPT1
PLSCR3
NLGN2
LYRM5
PCMT1
ZMAT5
GBP4
TMEM127
SLC25A24
PPIH
ALOX15
SLC11A2
CASP6
RPL35A
GPRASP2
MRFAP1L1
JMJD1C
CCAR1
PTK2
CEP192
RAB40B
GAA
BLVRA
CCDC89
FNBP1
FN3KRP
CUX1
STRADB
SUGT1
---+-+-------?-----------++-++++++++
++-+++
--+-------+
+---+-----++++++
+++--+
++++-+
++++-+
-----+
++++-+
-----++++++
---?----+--------------+-++++++
+++-++
---+-++-++---+------++-+++
+-++++
--+--+-+++++++++
-+++++
+-++++
-------+---+-+++
--+-----+-+--+---+?---------+---+--++++++
-----++++-+
-+-+++
+-++++
++-+++
-----+
++-+++
+-------+------++--++
--+----------?------+
++++++--+++
+++-++
++++-+
+-++++
--++-+-++++
-----++++++
---+-+--+++--+-++--++
+-+-++
+-+--+
-+++++
-----+-++++
++++++
-+++++
--+----++-+---------------------+?------++++++
----+---?-+
++++-+
----+++++++
--+----+-++-++-+
++-++--+-------+---++----++-++++-+++
+-++++
---?-+
-----++++-+
++++++
+-++-+
+-++++
-------+--++--++
++++-+
-----+
---+-----------+
--------+-+-++-+
-+++++
++-++++++++
+-++-+
-----++++++
-----+--+----+---------?-+-+--++-------++-------+-++++-+
++++-+
+++-++
-----------+++++
++-+++
--+---
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-4.06
-4.058
-4.058
-4.057
-4.057
4.056
4.056
4.055
-4.055
-4.054
-4.054
-4.054
4.053
4.052
4.051
4.051
-4.051
4.051
-4.049
4.048
-4.048
-4.048
-4.048
-4.047
-4.047
4.046
4.044
-4.043
4.042
-4.04
-4.039
4.038
4.037
-4.036
4.036
4.036
4.036
4.035
-4.034
-4.033
4.032
-4.031
-4.03
-4.03
-4.029
-4.023
-4.023
-4.021
4.021
-4.018
4.018
4.017
4.016
4.016
-4.015
4.015
-4.015
-4.015
-4.015
4.014
-4.014
-4.014
-4.013
-4.012
4.012
4.012
4.012
4.012
4.012
-4.011
4.011
-4.009
4.009
-4.008
-4.007
-4.006
4.006
4.005
4.005
4.003
-4.002
4.001
4
4
-3.998
-3.998
-3.998
-3.997
-3.997
-3.997
-3.996
-3.996
3.995
-3.995
-3.995
3.995
-3.994
3.994
-3.994
-3.993
3.993
3.993
-3.992
-3.992
-3.991
-3.991
3.991
3.991
3.989
-3.989
-3.988
3.987
3.987
3.985
3.984
-3.981
-3.981
3.98
3.979
-3.979
-3.979
-3.978
-3.977
-3.977
-3.976
3.973
3.971
3.97
3.97
3.97
-3.968
3.968
-3.967
-3.965
-3.964
-3.964
-3.964
-3.962
-3.962
-3.96
-3.958
-3.957
3.957
3.956
3.956
-3.955
-3.955
3.954
3.953
-3.953
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
4.92E-05
4.94E-05
4.95E-05
4.96E-05
4.97E-05
4.99E-05
4.99E-05
5.02E-05
5.02E-05
5.04E-05
5.04E-05
5.04E-05
5.06E-05
5.09E-05
5.09E-05
5.10E-05
5.11E-05
5.11E-05
5.14E-05
5.16E-05
5.16E-05
5.17E-05
5.18E-05
5.19E-05
5.20E-05
5.21E-05
5.26E-05
5.28E-05
5.30E-05
5.34E-05
5.38E-05
5.40E-05
5.41E-05
5.43E-05
5.44E-05
5.44E-05
5.44E-05
5.46E-05
5.48E-05
5.50E-05
5.53E-05
5.56E-05
5.57E-05
5.58E-05
5.61E-05
5.75E-05
5.76E-05
5.80E-05
5.81E-05
5.86E-05
5.88E-05
5.90E-05
5.92E-05
5.93E-05
5.95E-05
5.95E-05
5.95E-05
5.96E-05
5.96E-05
5.96E-05
5.96E-05
5.97E-05
5.99E-05
6.01E-05
6.02E-05
6.02E-05
6.02E-05
6.02E-05
6.03E-05
6.05E-05
6.05E-05
6.10E-05
6.11E-05
6.13E-05
6.14E-05
6.18E-05
6.18E-05
6.19E-05
6.19E-05
6.25E-05
6.29E-05
6.31E-05
6.32E-05
6.33E-05
6.38E-05
6.40E-05
6.40E-05
6.41E-05
6.41E-05
6.43E-05
6.44E-05
6.44E-05
6.46E-05
6.47E-05
6.47E-05
6.48E-05
6.49E-05
6.50E-05
6.50E-05
6.53E-05
6.53E-05
6.53E-05
6.56E-05
6.56E-05
6.57E-05
6.57E-05
6.57E-05
6.59E-05
6.64E-05
6.65E-05
6.68E-05
6.70E-05
6.70E-05
6.74E-05
6.77E-05
6.87E-05
6.88E-05
6.88E-05
6.92E-05
6.93E-05
6.93E-05
6.96E-05
6.97E-05
6.99E-05
7.01E-05
7.10E-05
7.16E-05
7.17E-05
7.18E-05
7.19E-05
7.24E-05
7.25E-05
7.29E-05
7.33E-05
7.36E-05
7.37E-05
7.38E-05
7.42E-05
7.44E-05
7.49E-05
7.55E-05
7.59E-05
7.59E-05
7.63E-05
7.64E-05
7.66E-05
7.67E-05
7.69E-05
7.71E-05
7.72E-05
17564
24984
21652
49858
54353
18047
36295
51193
32794
17023
52822
17309
28802
49609
49425
34215
50119
54582
42462
61724
10903
28839
61615
16820
43840
32574
3314
59126
29438
43752
55634
16753
19571
32916
5490
36047
21552
64680
4071
9732
24296
3582
45758
801
22844
25581
12042
56704
15929
17345
55758
11158
62114
54941
39741
27874
4604
13671
17616
63109
9771
3192
4549
67415
30541
55523
22124
19161
66717
17081
13198
8743
4100
2757
352
31184
48475
9047
65888
4176
43035
29201
7346
16033
66946
55119
16894
38805
11460
43810
67838
4062
40531
22434
64996
21555
65439
11152
64153
10775
60601
30799
28021
34312
16564
58916
23093
9217
22368
2258
13333
55018
22677
66249
57878
1870
9092
6965
45259
5760
12702
14871
39392
49707
4510
14878
40911
50136
11137
28185
2928
42513
62414
38670
64728
29330
45184
15169
50783
57863
43450
12015
61119
24375
8055
18662
23962
63991
19840
8762
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
22878
11068
79960
65981
5189
2030
51304
80765
23457
11019
27243
9736
5443
55745
55002
27030
9200
9711
65220
5108
687
9811
23002
23386
10295
55014
5106
9943
8705
5931
51092
83938
55502
158586
115752
54861
83943
94240
11251
112869
7514
3157
57559
3590
2950
51654
54884
159371
55435
65056
134492
10455
80319
9527
381
51406
64422
6251
8161
10724
256380
6259
51393
4528
25962
7813
958
9470
29110
4144
55813
4781
84959
126382
79817
55109
114801
27106
10043
5209
10493
952
57565
79596
4973
1296
23396
28957
6881
141
64746
55454
94081
7512
10661
113802
4882
283229
11330
10277
25957
3181
51257
10054
158046
170506
84146
51586
22953
79631
3142
26091
64743
257
8241
284942
100129828
124637
6746
4940
285533
4607
6399
131870
55172
9261
4171
5903
23369
285989
4744
86
9414
7771
29015
27345
55346
113402
8543
51278
79602
5884
259266
57493
29101
79568
388610
27352
23075
54622
TRAPPC8
CYB561D2
PHF17
CAPRIN2
PEX1
SLC29A1
ZDHHC3
STARD5
ABCB9
LIAS
CHMP2A
USP34
POMC
AP5M1
TMCO3
MLH3
PTPLA
KIAA0226
NADK
PCM1
KLF9
CTIF
DAAM1
NUDCD3
BCKDK
STX17
PCK2
OXSR1
B3GALT4
RBBP7
SIDT2
C10orf11
HES6
ZXDB
DIS3L
SNRK
IMMP2L
EPSTI1
PTGDR2
CCDC101
XPO1
HMGCS1
STAMBPL1
IL11RA
GSTP1
CDK5RAP1
RETSAT
SLC35G1
AP1AR
GPBP1
NUDCD2
ECI2
CXXC4
GOSR1
ARF5
NOL7
ATG3
RSU1
COIL
MGEA5
SCML4
RYK
TRPV2
MTIF2
KIAA1429
EVI5
CD40
EIF4E2
TBK1
MAT2A
UTP6
NFIB
UBASH3B
NR2C2AP
MOB3B
AGGF1
TMEM200A
ARRDC2
TOM1
PFKFB3
VAT1
CD38
KLHL14
RNF219
OLR1
COL8A2
PIP5K1C
MRPS28
TAF10
ADPRH
ACBD3
CSGALNACT2
SFXN1
XPNPEP2
KLF1
HENMT1
NPR2
EFCAB4A
CTRC
UBE4B
PNISR
HNRNPA2B1
MARCH2
UBA2
NXNL2
DHX36
ZNF644
MED15
P2RX2
EFTUD1
HLX
HERC4
WDR13
ALX3
RBM10
RPL23AP82
RNF130
CYB5D1
SSR2
OAS3
RNF175
MYBPC3
TRAPPC2
NUDT16
DNAAF2
MAPKAPK2
MCM2
RANBP2
PUM2
ZNF789
NEFH
ACTL6A
TJP2
ZNF112
SLC43A3
KCNMB4
TCP11L1
SFT2D1
LMO4
IER5
ADIPOR2
RAD17
ASPM
HEG1
SSU72
C2orf47
TRNP1
SGSM3
SWAP70
ARL15
--+--++-+++
-----+-------?-++++-+
+-++++
-----+
-----+
---+-++++-+
-+------+-+
--+--+-+-++
+--+-+++-++
++-+-+
+++--+
+-------+-+++?++
+--+-------+++++
-----++-+++
++-+++
++++++
--+--++-+++
-+++-+
+++++-------------?-+
-----+++?++
+++++-----+-+-------+
-----+---+-+++++
-----++---+
-------+-+--+----+?------+++-++
------+++++
---+-++++++
+-------+-+-+------------++-+++
---+------+++-++
-----++++-+
+-+++-----+
--+--++++++
----------+
----------++-+++
-----++++++
++++++
+++-++
--++-+
-----+
--+--++++++
++-+++
++-+++
--+---+-+++
-+++-+
--+--+-++-+
-----++-+++
++-++++++++
-----+++--+
++++++
+-++-+
--+-----+-++-++---+--+++++
-----+-+--++-?++
++++++
-----+++-++
+-+--++-+++
++++++
-----+
++++++
+-+?-+
-----+++-++
++++-+
+---++
+++-++
+-----+++-+
--+--+-++-+
-----+
--+------------+
-----+
--+--++++++
-----++-+-+
--+--++++++
--++++
++++++
+-++++
++-+++
----+---++++-+++
-----+
--+?-++++++
-----+
-----+-++++
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
-3.952
3.951
-3.949
-3.949
-3.948
3.948
3.947
-3.943
-3.942
-3.942
3.94
-3.939
-3.939
-3.938
3.938
-3.937
3.937
3.936
3.935
-3.935
-3.932
3.932
-3.931
-3.93
3.93
-3.93
3.93
3.929
3.928
-3.928
3.928
3.927
3.927
-3.926
-3.925
-3.924
-3.924
3.924
3.924
-3.923
-3.922
-3.922
-3.921
-3.92
3.92
-3.92
3.92
-3.918
-3.918
-3.916
-3.916
-3.916
3.915
-3.915
3.915
-3.914
3.913
-3.913
-3.912
-3.912
-3.912
-3.909
3.907
-3.907
-3.905
3.905
-3.904
3.904
3.903
-3.903
-3.901
3.9
-3.9
-3.9
-3.899
-3.897
3.895
-3.895
3.893
3.892
3.891
-3.891
-3.89
-3.889
3.889
3.888
3.888
-3.887
3.887
3.886
-3.886
3.886
-3.885
3.885
3.884
3.883
-3.883
3.882
3.881
3.881
-3.881
-3.88
3.879
-3.879
3.876
-3.875
-3.873
3.872
3.872
-3.872
3.87
-3.87
3.869
3.868
-3.868
3.868
3.866
-3.865
3.864
3.864
3.863
3.861
-3.859
3.858
-3.857
3.857
-3.857
-3.856
-3.856
-3.855
-3.855
-3.854
3.854
-3.854
3.854
-3.853
3.853
3.853
3.851
3.85
3.85
-3.849
-3.849
3.848
-3.848
-3.847
3.846
-3.846
-3.846
3.846
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
7.74E-05
7.79E-05
7.84E-05
7.84E-05
7.87E-05
7.87E-05
7.90E-05
8.03E-05
8.08E-05
8.09E-05
8.15E-05
8.17E-05
8.20E-05
8.20E-05
8.23E-05
8.26E-05
8.26E-05
8.28E-05
8.33E-05
8.33E-05
8.41E-05
8.42E-05
8.47E-05
8.48E-05
8.49E-05
8.50E-05
8.50E-05
8.54E-05
8.55E-05
8.57E-05
8.58E-05
8.59E-05
8.60E-05
8.64E-05
8.69E-05
8.71E-05
8.71E-05
8.72E-05
8.72E-05
8.74E-05
8.76E-05
8.78E-05
8.82E-05
8.84E-05
8.85E-05
8.85E-05
8.87E-05
8.92E-05
8.92E-05
8.99E-05
9.00E-05
9.01E-05
9.02E-05
9.03E-05
9.04E-05
9.09E-05
9.10E-05
9.13E-05
9.14E-05
9.15E-05
9.17E-05
9.25E-05
9.33E-05
9.34E-05
9.43E-05
9.43E-05
9.44E-05
9.47E-05
9.50E-05
9.52E-05
9.59E-05
9.61E-05
9.62E-05
9.63E-05
9.64E-05
9.73E-05
9.81E-05
9.82E-05
9.90E-05
9.94E-05
9.99E-05
9.99E-05
1.00E-04
1.01E-04
1.01E-04
1.01E-04
1.01E-04
1.02E-04
1.02E-04
1.02E-04
1.02E-04
1.02E-04
1.02E-04
1.03E-04
1.03E-04
1.03E-04
1.03E-04
1.04E-04
1.04E-04
1.04E-04
1.04E-04
1.05E-04
1.05E-04
1.05E-04
1.06E-04
1.07E-04
1.08E-04
1.08E-04
1.08E-04
1.08E-04
1.09E-04
1.09E-04
1.09E-04
1.10E-04
1.10E-04
1.10E-04
1.11E-04
1.11E-04
1.12E-04
1.12E-04
1.12E-04
1.13E-04
1.14E-04
1.14E-04
1.15E-04
1.15E-04
1.15E-04
1.15E-04
1.15E-04
1.16E-04
1.16E-04
1.16E-04
1.16E-04
1.16E-04
1.16E-04
1.17E-04
1.17E-04
1.17E-04
1.18E-04
1.18E-04
1.18E-04
1.19E-04
1.19E-04
1.19E-04
1.19E-04
1.20E-04
1.20E-04
1.20E-04
1.20E-04
1.20E-04
35688
47113
27062
28110
27868
12190
67510
29084
35762
9835
37065
47493
8924
64085
68382
50026
42119
15574
19207
25216
7466
59141
43908
35177
31136
50274
43568
37528
31869
67964
40865
59642
3971
44827
38435
16971
34147
42055
8583
46057
19889
34190
43965
61837
21183
52186
62541
14356
65962
41331
55404
28453
35630
67761
3495
50033
48553
15864
52983
53973
20342
23593
7362
51406
68183
55480
25117
4029
8516
59978
11510
45106
1435
64803
2842
12102
11536
49208
43412
56032
24585
63876
31920
52345
587
56962
63693
28237
46589
1042
18361
25936
30841
62004
41802
59509
10345
65912
2377
7386
5336
52659
22269
16342
39056
20632
20027
3112
14397
23411
47399
40001
63938
29136
3365
33693
51768
43870
36552
30797
47368
64798
24786
43974
38722
43280
60569
42664
5059
57411
22559
28672
44577
39725
10067
26493
497
7665
2023
52207
38874
3663
58487
26572
56932
64236
13312
8038
33385
1214
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
8519
348094
26015
57655
7779
6341
126069
55755
2289
56963
6197
79670
340419
90627
56172
51322
26286
2029
599
83707
51095
10714
1175
80169
84939
55055
2271
283989
55112
25900
10461
10013
5359
92342
1176
22906
11118
1326
257160
340198
55311
79016
7462
10224
23112
9874
26086
23431
83706
5283
29925
11103
286183
10127
51444
861
55793
7753
51729
25998
85865
54069
26133
9692
8521
10427
201161
10482
92691
57001
4739
5800
7170
7220
643008
143
54834
55787
972
134218
4976
22888
80223
132001
11051
7153
494470
11054
122970
9321
1791
54700
65265
7466
9440
51690
11193
9147
140947
6133
26469
23408
10072
219988
5357
115761
92714
9296
1513
2547
84628
160418
613
219790
56005
57563
1593
23049
6477
51282
343099
49855
9529
79966
84981
139818
8925
124454
55217
196
54522
348013
399967
5239
55802
4987
678
8536
641455
261734
84930
57674
87178
23313
89781
57659
55677
10800
4212
900
IFITM1
ANKDD1A
RPAP1
GRAMD1A
SLC30A1
SCO1
ZNF491
CDK5RAP2
FKBP5
RGMA
RPS6KA3
ZCCHC6
RSPO2
STARD13
ANKH
WAC
ARFGAP3
ENSA
BCL2L2
TRPT1
TRNT1
POLD3
AP2S1
CTC1
MUM1
ZWILCH
FH
TSEN54
WDR60
IFFO1
MERTK
HDAC6
PLSCR1
METTL18
AP3S1
TRAK1
BTN3A2
MAP3K8
RNF214
IFITM4P
ZNF444
DDA1
LAT2
ZNF443
TNRC6B
TLK1
GPSM1
AP4E1
FERMT3
PIGH
GMPPB
KRR1
NKAIN3
ZNF263
RNF138
RUNX1
FAM63A
ZNF202
WBP11
IBTK
GTPBP10
MIS18A
TRPC4AP
KIAA0391
GCM1
SEC24B
CENPV
NXF1
TMEM169
ACN9
NEDD9
PTPRO
TPM3
TRPC1
SMIM5
PARP4
GDAP2
TXLNG
CD74
DNAJC21
OPA1
UBOX5
RAB11FIP1
TAMM41
NUDT21
TOP2A
RNF165
OGFR
ACOT4
TRIP11
DNTT
RRN3
C8orf33
WFS1
MED17
LSM7
WBP4
NEMF
C5orf20
RPL9
PTPN18
SIRT5
DPP3
PATL1
PLS1
ARL11
ARRDC1
ATP6V1F
CTSK
XRCC6
NTNG2
TMTC3
BCR
RTKN2
C19orf10
KLHL8
CYP27A1
SMG1
SIAH1
SCAND1
CCDC18
SCAPER
BAG5
SCD5
MIR22HG
DOCK11
HERC1
EARS2
TMLHE
AHR
ANKRD16
TMEM255B
PATE2
PGM5
DCP1A
OPRL1
ZFP36L2
CAMK1
POTEM
NPHP4
MASTL
RNF213
PNPT1
KIAA0930
HPS4
ZBTB4
IWS1
CYSLTR1
MEIS2
CCNG1
++++++
++++++
----------+-++-+
----+---+----++--++++
++++++
--+--++++-+
++++++
++++++
-------+----+---+-+++
++++-+
---?-+
-----++++++
++-+++
------+---+---------++-+++
-----+-++++
++++++
++-+++
++++-+
-----+-++++
++++++
-+-+++
+-+--+
+----++-+++
-----+
++++++
-+++-+
----------+---------+
-----++-+++
--+-------+
-----++++++
--+--+
--+--++-+++
+++--+
------------+-----+------+++?-+
--++-+++?++
+-+---+-++++--++
-----------+++-+
+-++++
-+++++
+----++++++--+++
++++++
---++-+-+++
-----+----+++-++
++++++
+---+-------++-++++++
++++++
+++-++
+-----+-----+-----+------+
-+------+---+---+-----+--+
---+-+
++++++
-----++-+++
++++++
----+++++++
-+++-+
-+-+++
++++-+
-----+
+++--+
+----++++++
-------+---+++-+
++++++
-------+--++++++
--+-----?---+?-++-+++
+-++++
+-+----------+-+
+++?++
++++-+
-----++++++
+++--+
++++++
-+-+-++++-+
-----+
++++++
++++++
+-+?-+
+----++-+++
-++----++++
---+-+-------+-++++++-++++
--++--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
3.845
3.845
-3.845
-3.842
3.841
-3.841
-3.839
-3.838
3.838
3.837
-3.835
3.835
3.835
3.835
-3.834
-3.833
-3.833
3.832
3.832
-3.832
-3.831
3.829
3.828
-3.828
-3.827
-3.827
-3.827
3.826
-3.822
3.822
3.822
3.822
3.822
-3.819
3.818
3.818
3.817
3.816
-3.816
3.815
-3.815
3.815
3.815
-3.812
-3.811
-3.811
-3.811
-3.811
3.81
-3.809
-3.809
-3.805
3.805
-3.805
-3.804
3.803
3.802
-3.802
-3.802
-3.801
-3.8
-3.799
3.797
-3.797
3.797
-3.796
-3.793
3.792
-3.79
-3.79
3.79
3.79
3.788
-3.788
3.788
3.787
3.786
-3.786
3.786
-3.784
-3.782
3.781
3.78
-3.78
-3.777
-3.777
3.777
3.777
3.775
-3.774
-3.773
-3.772
-3.772
-3.772
-3.772
-3.771
-3.771
-3.769
-3.769
-3.767
3.767
-3.766
3.766
3.766
-3.765
3.765
3.765
3.764
3.764
-3.763
3.763
-3.762
3.762
-3.758
-3.753
3.753
3.752
-3.751
-3.751
3.751
-3.75
-3.75
-3.75
3.75
3.748
-3.748
-3.748
-3.748
3.748
3.747
-3.747
3.746
3.744
3.743
-3.743
3.741
-3.741
3.741
3.74
3.739
-3.738
3.738
-3.737
3.734
-3.733
-3.73
-3.73
3.729
3.729
-3.727
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.20E-04
1.20E-04
1.21E-04
1.22E-04
1.22E-04
1.23E-04
1.23E-04
1.24E-04
1.24E-04
1.24E-04
1.25E-04
1.25E-04
1.26E-04
1.26E-04
1.26E-04
1.27E-04
1.27E-04
1.27E-04
1.27E-04
1.27E-04
1.27E-04
1.29E-04
1.29E-04
1.29E-04
1.30E-04
1.30E-04
1.30E-04
1.30E-04
1.32E-04
1.32E-04
1.33E-04
1.33E-04
1.33E-04
1.34E-04
1.34E-04
1.35E-04
1.35E-04
1.36E-04
1.36E-04
1.36E-04
1.36E-04
1.36E-04
1.36E-04
1.38E-04
1.38E-04
1.38E-04
1.38E-04
1.39E-04
1.39E-04
1.40E-04
1.40E-04
1.42E-04
1.42E-04
1.42E-04
1.42E-04
1.43E-04
1.43E-04
1.44E-04
1.44E-04
1.44E-04
1.45E-04
1.45E-04
1.46E-04
1.46E-04
1.47E-04
1.47E-04
1.49E-04
1.50E-04
1.50E-04
1.51E-04
1.51E-04
1.51E-04
1.52E-04
1.52E-04
1.52E-04
1.53E-04
1.53E-04
1.53E-04
1.53E-04
1.54E-04
1.55E-04
1.56E-04
1.57E-04
1.57E-04
1.59E-04
1.59E-04
1.59E-04
1.59E-04
1.60E-04
1.61E-04
1.62E-04
1.62E-04
1.62E-04
1.62E-04
1.62E-04
1.63E-04
1.63E-04
1.64E-04
1.64E-04
1.65E-04
1.65E-04
1.66E-04
1.66E-04
1.66E-04
1.66E-04
1.66E-04
1.67E-04
1.67E-04
1.67E-04
1.68E-04
1.68E-04
1.69E-04
1.69E-04
1.71E-04
1.75E-04
1.75E-04
1.76E-04
1.76E-04
1.76E-04
1.76E-04
1.77E-04
1.77E-04
1.77E-04
1.77E-04
1.78E-04
1.78E-04
1.78E-04
1.78E-04
1.79E-04
1.79E-04
1.79E-04
1.80E-04
1.81E-04
1.82E-04
1.82E-04
1.83E-04
1.83E-04
1.83E-04
1.84E-04
1.85E-04
1.85E-04
1.86E-04
1.87E-04
1.88E-04
1.89E-04
1.91E-04
1.92E-04
1.92E-04
1.92E-04
1.94E-04
42691
60217
11955
62469
40250
46791
40454
34655
37645
39809
41494
60302
57258
16369
60179
36027
62047
22400
63329
62307
45135
24498
4863
24282
33413
43591
33978
9384
19000
2014
27694
42810
62496
25212
17144
60913
64028
27466
43025
42684
61465
22568
59156
57570
51439
11653
42251
8997
60973
9506
21266
22065
16797
42362
55122
3005
20859
19361
62615
42270
62213
1186
57793
54991
19627
39841
10181
13942
53588
27490
17082
12037
34041
6244
20681
3334
36922
14144
292
60818
28208
24196
12818
33861
38438
40582
38714
17168
1611
54432
49628
47226
39437
11044
23382
38734
58221
45231
31173
61974
4144
32566
30242
30164
20696
12952
65940
46341
34088
59002
28244
36966
44059
25081
51599
14568
52619
63236
36952
42423
15242
34944
22938
26725
2185
33429
13411
26562
41372
5451
24102
983
40376
32225
4642
53452
46156
61150
44353
41986
1949
68540
40580
457
31529
1859
45078
44547
65425
46291
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
5788
29105
51805
55625
6513
5495
404550
4591
116028
6117
55197
23411
8661
9215
90668
116092
84466
84078
3717
10514
56902
51088
11006
128869
23534
3484
7159
51067
9648
257106
54816
22931
116173
92399
57192
2771
57104
23043
84277
3159
124961
84908
5819
161198
9928
4170
733
126731
84817
54675
79836
23446
780
100129828
54849
126003
83657
5597
4689
8542
9512
23205
57150
90203
4582
2355
4697
29123
112950
3984
79017
23378
9326
57591
51608
5797
51259
55794
10284
92912
8082
163087
28988
84188
92815
283234
486
10726
26052
27042
10051
26272
4067
120526
10585
6277
4210
7398
3155
55214
56548
117143
10971
9637
118924
387521
5427
3759
79709
3257
79750
1195
116068
80216
182
90355
144577
51000
1973
9741
90025
7336
9124
284415
79038
23604
23230
2787
817
9905
254552
4221
284119
157247
8218
84693
84173
11079
7436
79098
54855
8733
11156
401548
22822
2186
10162
64753
8905
440138
PTPRC
C16orf80
COQ3
ZDHHC7
SLC2A1
PPM1B
C16orf74
TRIM37
RMI2
RPA1
RPRD1A
SIRT1
EIF3A
LARGE
LRRC16B
DNTTIP1
MEGF10
KBTBD7
JAK2
MYBBP1A
PNO1
KLHL5
LILRB4
PIGU
TNPO3
IGFBP1
TP53BP2
YARS2
GCC2
ARHGAP30
ZNF280D
RAB18
CMTM5
MRRF
MCOLN1
GNAI2
PNPLA2
TNIK
DNAJC30
HMGA1
ZFP3
FAM136A
PVRL2
CLEC14A
KIF14
MCL1
C8G
CCSAP
TXNDC17
CRLS1
LONRF3
SLC44A1
DDR1
CACHD1
DEF8
TRAPPC5
DYNLRB2
MAPK6
NCF4
APOL1
PMPCB
ACSBG1
SMIM8
SNX21
MUC1
FOSL2
NDUFA4
ANKRD11
MED8
LIMK1
GGCT
RRP8
ZNHIT3
MKL1
GET4
PTPRM
TMEM216
DDX28
SAP18
UBE2Q2
SSPN
ZNF383
DBNL
FAR1
HIST3H2A
CCDC88B
FXYD2
NUDC
DNM3
DIEXF
SMC4
FBXO4
LYN
DNAJC24
POMT1
S100A6
MEFV
USP1
HMGCL
LEPREL1
CHST7
TADA1
YWHAQ
FEZ2
FRA10AC1
TMEM189
POLE2
KCNJ2
COLGALT1
HPS1
ZNF385D
CLK1
LYSMD3
ALPK1
JAG1
C5orf30
C12orf66
SLC35B3
EIF4A1
LAPTM4A
UBE3D
UBE2V2
PDLIM1
VSTM1
ZFYVE21
DAPK2
VPS13A
GNG5
CAMK2D
SGSM2
NUDT8
MEN1
PTRF
MGC27345
CLTCL1
MCEE
ELMOD3
RER1
VLDLR
C1orf116
FAM46C
GPAA1
PTP4A3
SNX30
PHLDA1
BPTF
LPCAT3
CCDC136
AP1S2
ALG11
----+--------+-++++-+
++-+++
--+--+
-----+
+-------+----------+--+----+--+---++++-++
+++?++
++++++
+-++++
++++-+
------------+--++++-+
+----++-+++
++++++
---+++
-+++---+--++++++
--+-+--+--+++++----+++-++++++-+
++++++
---+-----------+
---+------+++?++
++++++
----+--++-+
++++++
+-++-+
++++++
--++++-++-+
+-++++
---+-+++-+++++++
++++++++?+---+-+++-+-+++++
---+-+++++--+--++++++
++-+++
+++--+
++++++
-----+
-+++++
++-+++
--++-+
--------++++++++
-+-+++
++++-+
++++++
------+----------++------++++++
++++++
++-?++++-++
----------+
+++-++
-+-----+-------++++++
+---------+++?+++++++
-+-?-+-++++
--+--+-+-++
--+--+--+++
+-++-+
-+---++-+++
---+++-+-++
++-+++
++++++
-+--+--+----+--+++-++
++++-+
+-++-+
-------------?-+-+?-+
--+----+--++-++++++-+
++++++
++++-+
+--+-++++++
-+--------++--++
-+---++++++
-----+
--++-+
-----++++++
-+-+++
+++-++
++++++
+++++-+-+++
-----+-++++
++++++
--+--++++++
++-+++
+-++++
---+--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-3.726
-3.724
-3.723
3.722
3.722
-3.721
-3.721
-3.719
-3.719
-3.718
-3.718
-3.717
-3.716
-3.714
3.712
3.712
3.71
3.709
3.708
-3.708
-3.708
-3.708
3.707
-3.707
3.707
3.706
3.703
-3.703
-3.702
3.701
-3.7
-3.7
3.7
-3.7
3.699
3.699
3.699
-3.699
-3.699
-3.697
-3.697
-3.696
3.696
3.695
-3.695
3.695
3.694
3.693
3.693
-3.692
3.691
3.691
-3.691
-3.691
3.691
3.69
3.69
-3.687
3.686
3.685
-3.685
3.684
-3.682
3.682
3.682
3.682
3.681
-3.68
3.679
3.679
-3.678
-3.676
-3.675
3.674
3.672
3.669
3.668
-3.668
-3.668
-3.668
-3.668
-3.666
3.666
3.665
3.665
3.664
-3.664
-3.663
3.663
-3.663
-3.661
-3.66
3.66
-3.659
-3.657
3.655
3.655
-3.654
3.652
-3.652
3.652
-3.651
3.65
3.649
-3.648
3.648
-3.648
3.647
3.646
3.646
-3.643
-3.643
-3.643
3.642
3.642
3.642
-3.642
-3.641
-3.641
3.641
-3.64
-3.64
3.64
3.64
3.64
3.639
-3.639
3.638
-3.638
-3.638
3.637
-3.637
3.634
-3.634
3.634
-3.632
3.632
3.632
3.631
3.631
3.63
3.629
-3.629
3.629
3.629
-3.628
3.628
3.627
3.627
-3.626
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.95E-04
1.96E-04
1.97E-04
1.98E-04
1.98E-04
1.98E-04
1.99E-04
2.00E-04
2.00E-04
2.01E-04
2.01E-04
2.02E-04
2.02E-04
2.04E-04
2.05E-04
2.06E-04
2.08E-04
2.08E-04
2.09E-04
2.09E-04
2.09E-04
2.09E-04
2.10E-04
2.10E-04
2.10E-04
2.10E-04
2.13E-04
2.13E-04
2.14E-04
2.15E-04
2.15E-04
2.16E-04
2.16E-04
2.16E-04
2.16E-04
2.16E-04
2.16E-04
2.17E-04
2.17E-04
2.18E-04
2.18E-04
2.19E-04
2.19E-04
2.20E-04
2.20E-04
2.20E-04
2.21E-04
2.22E-04
2.22E-04
2.23E-04
2.23E-04
2.23E-04
2.23E-04
2.24E-04
2.24E-04
2.24E-04
2.25E-04
2.27E-04
2.28E-04
2.29E-04
2.29E-04
2.30E-04
2.31E-04
2.32E-04
2.32E-04
2.32E-04
2.32E-04
2.33E-04
2.34E-04
2.35E-04
2.35E-04
2.37E-04
2.38E-04
2.39E-04
2.41E-04
2.43E-04
2.44E-04
2.44E-04
2.44E-04
2.45E-04
2.45E-04
2.46E-04
2.47E-04
2.47E-04
2.48E-04
2.48E-04
2.49E-04
2.49E-04
2.50E-04
2.50E-04
2.51E-04
2.52E-04
2.52E-04
2.53E-04
2.55E-04
2.57E-04
2.57E-04
2.58E-04
2.60E-04
2.60E-04
2.61E-04
2.61E-04
2.62E-04
2.63E-04
2.64E-04
2.64E-04
2.64E-04
2.66E-04
2.66E-04
2.67E-04
2.69E-04
2.69E-04
2.70E-04
2.70E-04
2.71E-04
2.71E-04
2.71E-04
2.72E-04
2.72E-04
2.72E-04
2.72E-04
2.72E-04
2.73E-04
2.73E-04
2.73E-04
2.74E-04
2.74E-04
2.75E-04
2.75E-04
2.75E-04
2.75E-04
2.76E-04
2.79E-04
2.79E-04
2.79E-04
2.81E-04
2.81E-04
2.81E-04
2.82E-04
2.83E-04
2.83E-04
2.84E-04
2.85E-04
2.85E-04
2.85E-04
2.86E-04
2.86E-04
2.87E-04
2.87E-04
2.88E-04
22076
6351
4424
44346
12399
2895
40131
3704
16883
37543
36991
20101
12665
14943
68176
56730
20242
21928
50203
59169
32514
41760
38404
31257
26250
67192
41295
57738
42555
20970
61873
8623
28689
63124
25142
17711
61006
48695
35883
36397
18230
63347
30565
11224
44800
17731
60807
39860
2576
42512
25535
65656
63611
26912
30129
10186
4258
25500
44162
27698
46828
59223
26219
58250
41409
20050
49958
29800
30875
21642
51689
62077
1023
436
7259
45028
30314
52639
66119
34219
12477
56343
11425
3019
53530
55303
28914
53985
31110
68482
5797
49896
64576
29561
3829
3637
13335
11171
3405
39905
23642
390
38891
3858
14671
59162
37986
40451
62171
46893
20908
13657
32140
2240
21777
51344
50226
13526
1043
34530
2349
67600
39528
50702
36890
28548
61157
3496
49103
59564
26011
37035
58672
28617
7992
65685
57320
58579
13031
50337
24431
54385
60921
15877
23072
37907
5655
41860
66089
30036
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
57801
375775
51692
161502
64786
8216
57212
100129828
20
391
26130
55728
23421
10628
6782
4826
29079
203522
284459
84747
5473
149420
90550
5532
5909
11041
3034
51816
5509
10873
9145
5786
128308
3560
3654
79866
9131
55646
3679
25912
23181
25831
79042
9815
9325
1748
81786
8202
790
950
80005
64374
151790
59271
152302
64376
5337
54823
1609
29089
9467
2767
54476
6850
85444
79364
8976
4478
160364
6641
3703
161
23450
2098
284098
5469
3559
4713
4999
26959
84514
9623
9772
10336
4300
63908
80195
55848
128338
11196
55909
11010
83591
3663
80829
79622
151613
8859
3418
23357
5868
256051
201164
64924
9807
57634
57862
23533
26468
8740
147923
5054
23424
7625
8477
51276
6634
10179
128061
4799
6775
84674
6821
91408
57786
2157
1642
4775
51601
26031
9646
79621
5144
84498
84706
55799
11183
348645
11260
29087
5321
9497
9526
92105
60314
3303
7086
1998
4241
201134
HES4
PNPLA7
CPSF3
C15orf26
TBC1D15
LZTR1
TP73-AS1
SIRPB1
ABCA2
RHOG
GAPVD1
N4BP2
ITGB3BP
TXNIP
HSPA13
NNAT
MED4
DDX26B
HKR1
UNC119B
PPBP
PDIK1L
MCU
PPP3CB
RAP1GAP
B3GNT1
HAL
CECR1
PPP1R3D
ME3
SYNGR1
PTPRA
MRPL55
IL2RB
IRAK1
BORA
AIFM1
LYAR
ITGA7
C1orf43
DIP2A
HECTD1
TSEN34
GIT2
TRIP4
DLX4
TRIM7
NCOA3
CAD
SCARB2
DOCK5
SIL1
WDR49
EVA1C
CIDECP
IKZF5
PLD1
SWT1
DGKQ
UBE2T
SH3BP5
GNA11
RNF216
SYK
LRRCC1
ZXDC
WASL
MSN
CLEC12A
SNTB1
STT3A
AP2A2
SF3B3
ESD
PIGW
MED1
IL2RA
NDUFB7
ORC2
HBP1
GHDC
TCL1B
KIAA0195
PCGF3
MLLT3
NAPB
TMEM254
PLGRKT
DRAM2
SEC23IP
BIN3
GLIPR1
THAP2
IRF5
ZFP91
SNRNP25
TTC14
STK19
IDH2
ANGEL1
RAB5A
ZNF549
PLD6
SLC30A5
IP6K1
EP400
ZNF410
PIK3R5
LHX6
TNFSF14
ZNF420
SERPINE1
TDRD7
ZNF74
GPR65
ZNF571
SNRPD3
RBM7
C1orf131
NFX1
STAT4
CARD6
SUOX
BTF3L4
RBAK
F8
DDB1
NFATC3
LIPT1
OSBPL3
CTR9
RNASEH2B
PDE4D
FAM120B
GPT2
CACNA2D3
MAP4K5
C22orf34
XPOT
THYN1
PLA2G4A
SLC4A7
MPDU1
INTS4
C12orf10
HSPA1A
TKT
ELF2
MFI2
CEP112
+++++-+-?-+
---+-++-++--+-+++-+++
-----+++?++
++-?-+
++++++
---+----+-----++-++++
--++-++++-+
--++-+-----+-----+--+++++--+--++++++
----+++++++
-----+-+-++
-+++++
+-++-+
++-+++
++++++
++++-+
---+-+
++-+++
+++--+
---?--+-+----?-++++++
+-++++
++++-+
-----+++-++
-+++++
+++-++
+++?++
++++-+
----------++++-+
+++-++
++++-+
+++-++
++++++
++++++
--+--+-++-+
+-+++++-+++
-----+
-++-++
-----+
-----+
-+++-+
----++++-++
-----++++++
+++?++
++++++
-----+
-----++------+--------+--+--+++
-+-+++
-----+-++++
++++-+
-----++--++
+-++++
+++--++-+++
--------+---+------+++++++
++++-+
---+-++-?++
---+------+
--+--+++-++
++++++
---+-+-+-----+-+
----------++++++
-----++-+++
++-+-+
++++++
+++-++
--+--++++++
+++?++
-----+
++++++
------------+-------+
--+--++-+++++--+
++++++
--++----+-++-+++
----++---------++-+++
+-+----++-+----------+-+++
--++-+
+-+---------------?-++++++
+-----+++++
-+--------+-++++
-+++-+
++++++
+-+-++
++----
7257
6376
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
3.626
-3.624
-3.624
3.623
-3.622
3.622
-3.621
3.621
3.619
3.619
-3.617
-3.615
-3.614
3.614
-3.612
3.611
-3.61
-3.608
-3.608
-3.608
3.607
-3.607
3.607
-3.606
3.606
-3.605
3.605
3.603
3.602
3.602
3.601
3.601
-3.6
3.6
3.599
-3.599
-3.599
-3.598
3.595
3.595
3.594
-3.594
3.594
3.594
3.594
3.593
3.592
-3.592
-3.592
3.591
3.591
3.589
3.588
3.587
3.587
-3.587
3.586
-3.585
3.584
-3.583
3.583
-3.583
-3.582
3.581
-3.581
3.58
-3.579
3.579
3.578
3.577
-3.577
-3.576
-3.575
-3.574
-3.573
-3.572
3.571
3.57
-3.569
3.568
3.568
-3.566
3.564
3.564
-3.564
3.563
-3.563
-3.561
-3.56
-3.556
3.556
3.556
-3.555
3.553
-3.552
-3.551
-3.551
3.551
3.551
-3.55
-3.55
-3.547
-3.547
-3.546
3.544
-3.543
3.542
3.542
3.541
3.541
-3.539
3.539
3.537
-3.536
3.536
-3.534
-3.533
-3.533
-3.533
-3.532
3.532
3.53
3.53
-3.53
-3.529
3.528
-3.528
-3.525
-3.525
3.524
-3.524
-3.519
-3.519
-3.519
3.519
-3.519
-3.518
-3.517
-3.517
-3.517
3.516
-3.515
3.514
-3.513
-3.512
3.512
3.511
3.511
3.511
-3.511
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.88E-04
2.90E-04
2.91E-04
2.92E-04
2.92E-04
2.93E-04
2.94E-04
2.94E-04
2.96E-04
2.96E-04
2.98E-04
3.00E-04
3.02E-04
3.02E-04
3.04E-04
3.05E-04
3.06E-04
3.08E-04
3.08E-04
3.09E-04
3.09E-04
3.10E-04
3.10E-04
3.10E-04
3.11E-04
3.12E-04
3.12E-04
3.15E-04
3.15E-04
3.16E-04
3.16E-04
3.17E-04
3.18E-04
3.19E-04
3.19E-04
3.19E-04
3.20E-04
3.20E-04
3.24E-04
3.24E-04
3.25E-04
3.26E-04
3.26E-04
3.26E-04
3.26E-04
3.28E-04
3.28E-04
3.28E-04
3.29E-04
3.30E-04
3.30E-04
3.32E-04
3.33E-04
3.35E-04
3.35E-04
3.35E-04
3.36E-04
3.38E-04
3.39E-04
3.40E-04
3.40E-04
3.40E-04
3.40E-04
3.42E-04
3.43E-04
3.44E-04
3.44E-04
3.45E-04
3.46E-04
3.48E-04
3.48E-04
3.49E-04
3.50E-04
3.51E-04
3.52E-04
3.54E-04
3.56E-04
3.57E-04
3.59E-04
3.60E-04
3.60E-04
3.62E-04
3.65E-04
3.66E-04
3.66E-04
3.66E-04
3.66E-04
3.69E-04
3.72E-04
3.76E-04
3.76E-04
3.77E-04
3.78E-04
3.81E-04
3.82E-04
3.83E-04
3.83E-04
3.84E-04
3.84E-04
3.85E-04
3.86E-04
3.90E-04
3.90E-04
3.91E-04
3.94E-04
3.95E-04
3.97E-04
3.98E-04
3.98E-04
3.99E-04
4.01E-04
4.02E-04
4.05E-04
4.06E-04
4.07E-04
4.09E-04
4.10E-04
4.11E-04
4.12E-04
4.12E-04
4.13E-04
4.15E-04
4.16E-04
4.16E-04
4.16E-04
4.18E-04
4.19E-04
4.23E-04
4.24E-04
4.25E-04
4.25E-04
4.32E-04
4.32E-04
4.33E-04
4.34E-04
4.34E-04
4.35E-04
4.36E-04
4.37E-04
4.37E-04
4.39E-04
4.40E-04
4.41E-04
4.43E-04
4.45E-04
4.45E-04
4.46E-04
4.46E-04
4.46E-04
4.47E-04
48538
40320
65535
20297
53336
26385
10615
28261
7141
34204
17825
65332
12138
206
10946
959
48128
19457
9440
40349
7850
12375
38125
61963
65385
47739
16830
48595
47509
15591
33941
9888
13293
54812
44112
43871
15625
11512
41576
13021
21718
68362
24366
42102
13299
60580
5301
16801
2703
1443
7175
58710
45395
3390
24747
58995
32958
1878
8011
11796
4905
1806
41346
26823
62629
27763
28811
7033
26146
34569
31210
56746
11734
51194
45777
7295
61103
35967
8756
19958
28873
51156
1415
55521
8232
2425
34903
6589
47478
4104
43050
5117
10588
29119
59387
30641
60453
23802
56991
59622
8978
58765
20359
61487
63421
41654
44
5644
56935
47528
50907
45340
64386
8565
21771
45761
55694
41609
55229
43556
38316
7828
43206
24890
60857
50457
9101
30084
6898
63657
54456
47563
33134
61849
40342
58395
44974
24204
54765
35723
23342
30452
67431
38649
61558
34489
26395
32828
39211
43856
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
963
10549
5693
64108
284371
93349
10168
8690
7187
10073
255043
9685
80745
9941
3848
7529
8863
27344
23729
282809
140890
6331
10953
51241
84926
8372
54453
170622
54440
5073
63894
347735
6908
57168
1327
23443
118788
170482
259197
54475
5332
7411
6891
91544
11320
11018
5170
64431
79722
79135
53371
23259
5888
133396
55680
7627
6192
54462
56606
64398
7046
4602
10445
79443
124152
832
84798
90933
152002
4968
23479
11124
6051
3416
79915
10023
55614
79192
9921
5265
3547
170959
80162
55602
79792
51122
83866
84259
2783
6503
7014
23587
57573
1857
55081
6223
55151
8744
7352
391267
30835
1294
3832
4831
19
9129
10492
65008
57419
51096
4289
10539
8243
7009
51144
10905
3685
9702
1832
55128
2811
7515
116224
283651
66035
57473
1302
10946
55604
57508
8508
10325
23753
55608
9770
2004
6804
5256
26018
5525
79729
57465
5922
11075
4610
55160
10419
146894
6286
765
CD53
PRDX4
PSMB5
RTP4
ZNF841
SP140L
ZNF197
JRKL
TRAF3
SNUPN
TMEM86B
CLINT1
THUMPD2
EXOG
KRT1
YWHAB
PER3
PCSK1N
SHPK
POC1B
SREK1
SCN5A
TOMM34
COX16
SPRYD3
HYAL3
RIN2
COMMD6
SASH3
PARN
VIPAS39
SERINC2
TBP
ASPHD2
COX4I1
SLC35A3
PIK3AP1
CLEC4C
NCR3
NLE1
PLCB4
VBP1
TAP2
UBXN11
MGAT4A
TMED1
PDPK1
ACTR6
ANKRD55
APOO
NUP54
DDHD2
RAD51
IL31RA
RUFY2
ZNF75A
RPS4Y1
CCSER2
SLC2A9
MPP5
TGFBR1
MYB
MCRS1
FYCO1
IQCK
CAPZB
C19orf48
TRIM41
XXYLT1
OGG1
ISCU
FAF1
RNPEP
IDE
ATAD5
FRAT1
KIF16B
IRX1
RNF10
SERPINA1
IGSF1
ZNF431
ATHL1
CDKN2AIP
GSDMD
COMMD2
TTTY11
DCUN1D5
GNB2
SLA
TERF2
ELP5
ZNF471
DVL3
IFT57
RPS19
TMEM38B
TNFSF9
UCP3
ANKRD20A11P
CD209
COL7A1
KIF11
NME2
ABCA1
PRPF3
SYNCRIP
MRPL1
SLC24A3
UTP18
MKLN1
GLRX3
SMC1A
TMBIM6
HSD17B12
MAN1A2
ITGAV
CEP57
DSP
TRIM68
GP1BA
XRCC1
FAM122A
HMGN2P46
SLC2A11
ZNF512B
COL11A2
SF3A3
LRRC16A
INTS2
NIPSNAP1
RRAGB
SDF2L1
ANKRD10
RASSF2
ELK3
STX1A
PHKA2
LRIG1
PPP2R5A
SH3D21
TBC1D24
RASA2
STMN2
MYCL
ARHGEF10L
PRMT5
CD300LG
S100P
CA6
+-++-+
-+-+++
-----+
++++++
---+----+---+--+-------+------+
++-++--+--+
--+--+++-+++-+++
-++-++
-----++-+++
+++?-+
+-+----+?-+-++++
-----+
-----++-+++
++-+++
+-+--+
---++++-?-+
--++--+-+++
++++++
------+++-+
---+-+
---+-+-++-+
--+--+
-+--------++++++
--+--++++++
++++-+
--++++++?++
+++-++
+---+---+----+---++-----++++?-+
+--+++
---+---+?-+--+-+------++++
--++-++++-+
---+--+++++
++--++
-----+
+++?++
-----+
++++++
-+++++
-+++++
-+--+-----+-++++
+----++-+-++++++
+----++++++
++-+++-++++
++-+++
--+---+------+-++++-+
+-++++
++++++
--++-++++-+
-+++++
------+---+--?-++-+-+
----++------+--+++-++
++-+-+
++++++
++++++
--++++
----------+++--+
-------+-------+-++++
--+----+----++------++++-+
--+--+----+-+--+
--+--++--------+
+++++---------+--++-+-++++
---+-+
---+++
-----+
-------+-----------------+
+-+---+++++
-----++--++
++++++
+----++++++
+++-++
---+---++-+++-++
++++++
++++++
--+--++++++
++++-+
-+++--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
3.51
3.509
-3.509
3.506
-3.506
-3.506
-3.505
-3.503
-3.502
-3.501
3.501
-3.5
-3.499
3.497
3.496
3.496
-3.495
3.494
3.494
-3.493
-3.492
3.492
-3.492
-3.49
3.49
3.488
3.486
-3.486
3.485
-3.485
3.485
3.483
-3.483
3.483
-3.482
-3.481
3.48
-3.48
-3.48
-3.479
3.478
-3.477
3.477
3.476
-3.476
3.475
3.474
-3.473
-3.473
-3.473
-3.473
-3.473
3.473
3.473
-3.472
-3.472
-3.472
-3.472
3.471
-3.471
3.47
-3.469
3.469
3.469
-3.468
3.468
-3.467
3.465
3.465
3.465
-3.465
-3.463
3.457
-3.456
-3.455
3.454
-3.454
3.454
3.453
3.453
3.453
-3.453
-3.452
-3.452
3.451
3.451
3.451
-3.451
3.45
3.45
-3.449
-3.448
-3.448
3.448
-3.448
-3.447
-3.446
3.445
3.444
3.443
3.442
3.442
-3.441
-3.44
3.439
-3.438
-3.438
-3.436
3.436
-3.435
-3.433
-3.432
-3.431
3.431
-3.431
-3.431
3.43
-3.429
-3.428
-3.428
3.428
-3.428
-3.428
-3.426
3.425
-3.425
3.425
-3.424
-3.423
-3.422
-3.422
-3.422
-3.422
-3.422
3.421
-3.42
3.42
3.419
-3.419
3.418
3.417
-3.414
-3.414
3.414
3.414
3.413
-3.413
3.413
3.411
-3.41
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
4.48E-04
4.49E-04
4.50E-04
4.54E-04
4.55E-04
4.55E-04
4.57E-04
4.60E-04
4.61E-04
4.63E-04
4.64E-04
4.64E-04
4.66E-04
4.70E-04
4.72E-04
4.73E-04
4.73E-04
4.76E-04
4.76E-04
4.77E-04
4.79E-04
4.79E-04
4.80E-04
4.82E-04
4.84E-04
4.87E-04
4.90E-04
4.91E-04
4.92E-04
4.93E-04
4.93E-04
4.96E-04
4.96E-04
4.96E-04
4.98E-04
4.99E-04
5.01E-04
5.02E-04
5.02E-04
5.04E-04
5.04E-04
5.06E-04
5.08E-04
5.09E-04
5.10E-04
5.11E-04
5.14E-04
5.14E-04
5.14E-04
5.14E-04
5.15E-04
5.15E-04
5.16E-04
5.16E-04
5.16E-04
5.16E-04
5.17E-04
5.17E-04
5.18E-04
5.19E-04
5.20E-04
5.22E-04
5.22E-04
5.22E-04
5.24E-04
5.24E-04
5.26E-04
5.30E-04
5.30E-04
5.30E-04
5.30E-04
5.34E-04
5.46E-04
5.49E-04
5.51E-04
5.52E-04
5.52E-04
5.53E-04
5.54E-04
5.54E-04
5.54E-04
5.55E-04
5.57E-04
5.57E-04
5.58E-04
5.58E-04
5.59E-04
5.60E-04
5.60E-04
5.61E-04
5.63E-04
5.64E-04
5.64E-04
5.64E-04
5.65E-04
5.66E-04
5.69E-04
5.71E-04
5.73E-04
5.76E-04
5.77E-04
5.78E-04
5.79E-04
5.81E-04
5.85E-04
5.86E-04
5.86E-04
5.90E-04
5.91E-04
5.94E-04
5.98E-04
5.99E-04
6.01E-04
6.02E-04
6.02E-04
6.02E-04
6.03E-04
6.07E-04
6.07E-04
6.08E-04
6.08E-04
6.09E-04
6.09E-04
6.13E-04
6.14E-04
6.15E-04
6.15E-04
6.18E-04
6.20E-04
6.21E-04
6.21E-04
6.22E-04
6.22E-04
6.22E-04
6.24E-04
6.25E-04
6.27E-04
6.27E-04
6.28E-04
6.30E-04
6.32E-04
6.39E-04
6.41E-04
6.41E-04
6.41E-04
6.43E-04
6.43E-04
6.44E-04
6.48E-04
6.49E-04
11057
4148
10455
9620
29522
44538
49254
2973
46286
61848
53242
8271
51476
43031
27542
28203
25293
19704
42490
52050
42815
13558
14664
55836
46816
12160
57679
54312
42493
58540
29299
41957
67808
4090
66938
40460
4214
1368
18894
4325
56128
67729
51092
25810
8680
3099
64991
50799
23846
23570
31403
65429
3860
5004
44185
7376
15584
24406
43623
33063
59966
56586
2000
47036
10124
37375
10033
33932
2742
49944
19193
37765
49060
66117
17032
18579
31428
10938
30162
33104
36866
63809
14977
52129
62722
61370
21128
4385
35690
32275
13926
66779
9886
63754
56056
14195
13951
36633
56745
15171
57069
57081
13393
3919
31727
45399
45592
13110
2355
41708
43782
1455
41324
12360
46504
60020
7511
62983
14156
11598
62893
38851
48042
55539
64207
462
46937
32565
9417
50407
14254
39250
19564
9406
6149
67955
15402
25080
7087
66077
22312
49055
14960
1674
40758
64186
45619
29261
12841
24462
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
10783
7791
79695
80714
1654
54931
161823
90780
9262
4338
11057
219931
55632
8263
1965
1508
51635
81671
9557
2752
5581
2963
9455
90701
51174
5979
85462
84343
3850
51107
80863
11258
10469
8463
79188
55610
54462
57496
3595
7277
221477
84516
28960
165140
57691
22870
79791
55605
10090
8226
51028
4779
55113
26097
148213
80017
9534
4524
23469
9810
8677
140809
23552
29988
51567
6801
51043
83667
285973
1089
23086
2521
7319
1463
23367
64863
79088
54534
56929
7536
5018
3431
92345
23532
29919
7695
55854
55500
150465
6533
84759
27031
160777
84138
10129
64087
93621
548645
139341
81605
1052
1901
80208
257415
57579
55191
4352
6446
4801
6625
246329
3964
160897
3985
80125
116448
7494
5058
80184
79947
133308
24149
57704
79800
79843
58528
9759
7355
51327
7011
677
728642
8760
387
23517
339175
51296
5118
79005
54812
4361
27335
5996
5338
114294
89882
79629
25850
80345
23203
NEK6
ZYX
GALNT12
PBX4
DDX3X
TRMT10C
ADAL
PYGO2
STK17B
MOCS2
ABHD2
TPCN2
G2E3
F8A1
EIF2S1
CTSB
DHRS7
VMP1
CHD1L
GLUL
PRKCE
GTF2F2
HOMER2
SEC11C
TUBD1
RET
FHDC1
HPS3
KRT3
APH1A
PRRT1
DCTN3
TIMM44
TEAD2
TMEM43
CCDC132
CCSER2
MKL2
IL12RB2
TUBA4A
C6orf89
DCTN5
DCPS
OXER1
KIAA1586
PPP6R1
FBXO31
KIF21A
UST
HDHD1
VPS36
NFE2L1
XKR8
CHTOP
ZNF681
C14orf159
ZNF254
MTHFR
PHF3
RNF40
STX10
SRXN1
CDK20
SLC2A8
TDP2
STRN
ZBTB7B
SESN2
ATG9B
CEACAM4
EXPH5
FUS
UBE2A
NCAN
LARP1
METTL4
ZNF426
MRPL50
FEM1C
SF1
OXA1L
SP110
NAF1
PRAME
C18orf8
ZNF136
ZC3H15
ETNK1
TTL
SLC6A6
PCGF1
NPHP3
CCDC60
SLC7A6OS
FRY
MCCC2
MRFAP1
DNAJC25
FUNDC1
URM1
CEBPD
S1PR1
SPG11
FAM133B
FAM135A
NADSYN1
MPL
SGK1
NFYB
SNRNP70
STAC3
LGALS8
GPR180
LIMK2
CCDC33
OLIG1
XBP1
PAK1
CEP290
DHDDS
SLC9B2
ZNF318
GBA2
CARF
FAM124B
RRAGD
HDAC4
SLC35A2
AHSP
TEP1
ZFP36L1
CDK11A
CDS2
RHOA
SKIV2L2
METTL2A
SLC15A3
PCOLCE
SCNM1
AFTPH
MRE11A
EIF3K
RGS1
PLD2
LACTB
TPD52L3
OCEL1
ZNF345
ZSCAN16
PMPCA
++--++
+-++++
---+-+------+----+---+----------++-+
--++++++++++-+++
--+?-++-+++
--++-++++++
+-+--+
+-++++
---+-+++++++++-+
--+--+++++--+----+--++-+++
++++-+
+-++++
++-+++
-+++++
--+---+-+++
-+-+-++++++
+-+--+
--+-----++---------+++++++
++++++
++-+++
-----+
++++-+
-++--++-+++
-----+
+-++++
+-----+-+++
--+--++--++
++++-+
-------++-+++--+
-----++++-+
---?-++-+++
-+++++
+++-+-----+
++--++
--+--++++++
+++-++
++--++
-----++++++
--------+-+-++++
++-+++
---+-+
----+---+---++-+-++++
-+------+-+
-+++++
---+-++-+++
++-+++
-------+?---+--+-++++
+-+-++
-+++++
--+--++++++
--+--+-++++
-+-?+-----+-+----+-------+
--++-+
+----+-++-+
-------+--++++-+
++-++--+--+
--+-------+
++-+++
+-++++
-----++++++
++++++
++++-+
-----++++-+
++---++-+++
----------++-+-+
-----+-++++
++++-+
+-++-+
++-+++
++-++++-+-+
+-+-------++++++
+-++-+
--++---++-++++++
++-+++
-+++-+
++++++
--++----+-+
++-+++
-+++++
++++-++++++
-------+--++++++
-----+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
3.409
3.408
-3.408
-3.408
-3.407
-3.406
-3.405
-3.404
3.402
-3.4
3.4
3.399
-3.398
3.397
-3.397
3.396
3.394
3.393
-3.393
3.392
3.392
-3.392
3.392
-3.391
-3.391
3.391
3.39
3.389
3.388
3.388
-3.388
3.387
-3.386
3.385
3.385
-3.384
-3.384
-3.382
-3.38
3.38
3.379
3.379
-3.378
3.378
-3.377
3.375
-3.375
3.375
-3.374
3.373
-3.373
3.371
3.371
-3.371
-3.371
3.369
-3.369
3.369
-3.368
3.368
3.367
3.367
-3.366
3.366
-3.366
3.365
3.365
3.365
-3.365
3.364
-3.363
-3.362
3.362
3.362
-3.362
-3.362
-3.362
-3.362
3.361
-3.359
-3.358
3.358
-3.358
3.355
3.355
-3.354
-3.354
-3.354
3.354
3.353
3.353
-3.352
3.352
-3.352
3.351
-3.351
-3.35
-3.349
-3.348
-3.348
3.348
-3.348
3.346
-3.345
-3.345
3.345
3.345
-3.345
-3.345
-3.344
3.344
3.343
-3.34
3.34
3.34
3.339
-3.339
3.339
-3.338
3.338
-3.338
-3.337
3.335
-3.335
3.335
3.334
3.334
3.333
3.332
3.331
-3.329
-3.328
3.328
3.326
-3.326
-3.326
3.325
3.325
3.325
3.325
-3.322
-3.322
3.322
3.32
3.32
3.319
-3.319
-3.319
3.319
-3.318
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
6.53E-04
6.53E-04
6.54E-04
6.55E-04
6.56E-04
6.60E-04
6.62E-04
6.64E-04
6.69E-04
6.73E-04
6.74E-04
6.75E-04
6.79E-04
6.81E-04
6.82E-04
6.85E-04
6.88E-04
6.91E-04
6.91E-04
6.93E-04
6.93E-04
6.94E-04
6.95E-04
6.96E-04
6.97E-04
6.98E-04
7.00E-04
7.01E-04
7.03E-04
7.04E-04
7.04E-04
7.07E-04
7.08E-04
7.11E-04
7.11E-04
7.14E-04
7.15E-04
7.20E-04
7.24E-04
7.25E-04
7.27E-04
7.29E-04
7.30E-04
7.31E-04
7.32E-04
7.39E-04
7.39E-04
7.40E-04
7.41E-04
7.42E-04
7.43E-04
7.48E-04
7.48E-04
7.49E-04
7.50E-04
7.54E-04
7.55E-04
7.56E-04
7.56E-04
7.56E-04
7.59E-04
7.61E-04
7.62E-04
7.62E-04
7.63E-04
7.64E-04
7.66E-04
7.67E-04
7.67E-04
7.68E-04
7.70E-04
7.73E-04
7.73E-04
7.73E-04
7.74E-04
7.74E-04
7.74E-04
7.75E-04
7.77E-04
7.82E-04
7.85E-04
7.85E-04
7.85E-04
7.93E-04
7.93E-04
7.96E-04
7.97E-04
7.97E-04
7.98E-04
7.99E-04
8.01E-04
8.02E-04
8.03E-04
8.03E-04
8.05E-04
8.06E-04
8.07E-04
8.12E-04
8.13E-04
8.15E-04
8.15E-04
8.15E-04
8.21E-04
8.22E-04
8.22E-04
8.22E-04
8.23E-04
8.23E-04
8.24E-04
8.25E-04
8.27E-04
8.28E-04
8.37E-04
8.38E-04
8.39E-04
8.40E-04
8.40E-04
8.40E-04
8.44E-04
8.45E-04
8.45E-04
8.48E-04
8.54E-04
8.54E-04
8.54E-04
8.57E-04
8.58E-04
8.60E-04
8.61E-04
8.64E-04
8.72E-04
8.74E-04
8.75E-04
8.80E-04
8.81E-04
8.83E-04
8.83E-04
8.85E-04
8.85E-04
8.86E-04
8.93E-04
8.95E-04
8.95E-04
8.99E-04
9.00E-04
9.02E-04
9.02E-04
9.02E-04
9.04E-04
9.07E-04
52443
45419
61397
33081
38663
62876
46941
48552
63935
50950
7151
31387
5084
24500
50458
55726
9372
4110
9645
17984
8729
12997
17784
51345
3238
57311
17474
42875
53167
52360
39554
31047
634
41343
21230
21455
49039
48748
56164
61556
33036
9957
43564
19331
31837
57812
27212
1163
15684
33333
56097
57868
28600
22001
9178
57014
616
46494
52680
63942
59200
30659
42531
41381
28770
40404
59684
47295
57496
65011
38060
26178
25386
21403
12274
22785
17634
20673
28957
56482
32971
5509
50999
36077
45343
34884
44570
40709
26729
15573
10895
56476
26536
22705
9983
28868
45755
52627
64558
17005
67911
2528
50914
28230
40246
54640
26566
33670
17556
31326
3027
27735
67822
37861
68459
11139
22631
39650
30516
32465
51854
65902
53908
60318
576
5360
36108
64503
54426
59247
32868
8735
37552
52119
23424
49764
11528
6151
44765
10136
26677
37197
15999
68214
10123
56519
33165
35359
42035
57015
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
123283
8795
80895
9862
2768
1153
55240
11116
55508
4636
4750
3773
6867
4013
2188
26258
27429
92840
9963
79101
80012
219670
51191
10962
79944
29920
9675
10370
6536
10026
54460
23780
840
54901
5606
10567
26224
9149
26999
392
10300
79159
5866
8021
65094
51093
27164
55778
9150
399
155038
222223
51503
54802
55296
6388
366
93627
9704
9972
10520
51409
2194
166655
8660
883
57580
23081
79847
54826
10363
3735
51513
10594
11080
648
22918
283209
57864
3074
64419
2791
23463
7767
79722
23276
105
55314
54543
6509
158234
2017
10020
51512
147040
5116
121665
9601
112487
7167
10730
224
2976
54981
4622
10077
5238
55631
6100
521
329
9439
81550
23480
57169
435
2826
23175
83999
56912
166793
2774
22866
1265
306
84548
267
64745
126282
203100
2873
2274
93650
6284
29074
26048
64327
51535
5734
9716
137682
7936
3708
57187
6799
201266
84720
85413
64110
9873
TARSL2
TNFRSF10B
ILKAP
MED24
GNA12
CIRBP
STEAP3
FGFR1OP
SLC35E3
MYL5
NEK1
KCNJ16
TACC1
VWA5A
FANCF
BLOC1S6
HTRA2
REEP6
SLC23A1
TAF1D
PHC3
ENKUR
HERC5
MLLT11
L2HGDH
PYCR2
TTI1
CITED2
SLC6A9
PIGK
MRPS21
APOL2
CASP7
CDKAL1
MAP2K3
RABAC1
FBXL3
DYRK1B
CYFIP2
ARHGAP1
KATNB1
NOL12
RAB3IL1
NUP214
JMJD4
RRNAD1
SALL3
ZNF839
CTDP1
RHOH
GIMAP8
KIAA1324L
CWC15
TRIT1
TBC1D19
SDF2
AQP9
TBCK
DHX34
NUP153
ZNF211
HEMK1
FASN
TRIM60
IRS2
CCBL1
PREX1
KDM4C
TMEM180
GIN1
HMG20A
KARS
ETV7
PRPF8
DNAJB4
BMI1
CD93
PGM2L1
SLC46A2
HEXB
MTMR14
GNG11
ICMT
ZNF224
ANKRD55
KLHL18
ADARB2
TMEM144
TOMM7
SLC1A4
TRMT10B
CTTN
GNE
GTSE1
KCTD11
PCNT
SPPL3
PDIA4
DTD2
TPI1
YME1L1
ALDH3A2
GTF3C2
NMRK1
MYH4
TSPAN32
PGM3
LRRC40
RP9
ATP5I
BIRC2
MED23
TDRD3
SEC61G
ZNFX1
ASL
CCR10
LPIN1
KREMEN1
IFT46
ZBTB49
GNAL
CNKSR2
CNN2
ANXA3
TMEM185A
AMFR
METTL17
TNFAIP8L1
HTRA4
GPS1
FHL2
ACPT
S100A13
MRPL18
ZNF500
LMBR1
PPHLN1
PTGER4
AQR
NDUFAF6
NELFE
ITPR1
THOC2
SULT1A2
SLC39A11
PIGO
SLC22A16
MAGEF1
FCHSD2
-----+--+-+
+-++++
-----+
++-++----+-+-+++
+-+--+-+-++
---+-+---+++++++
+-+--+
++++++
-+---+++---+++++
-----+
++++++
--+--+----++--+++++++
---?+-+-------++
+----+-+?-+
+++++--+-------++++++
+--+++
-----+++++++++++
+-+--++-+++
-----+
++-?++
++-+++
-----+
++-+++++++-----+
++++++
+++-++
------+++++
-++-+---+-+
+-----------++-++-+++
+-++++
+-++++
---?-+++-++
+---------+
+---------+
-+-+++
--++-+
-----+
+++--+
+----+++-++
--+-----?--+-+-++-+++
-----+
--+--+------+--+--++++++-+
--++-+
-+++-+
++-++++-+++
---+----+-+-++-+
+++-++
+-++-+
---+-++++++
-+--+++-++-----+
---?-++++++
---+---++---+--+
---++-+++++
-+++-----++
-----+
+----+++-++
-+++++
---+---+------+-+++++
+-++---+--+
-+--+--++++
++-+++
+-+--+
++-+++
+----+
+++-+---+-+++-++
++++++
-++++--+--+++?-+
++-++++-+++
-----------+++++
+--+++
+++++++++++
++++-+
---+--+---+
--+-----+-+-+--+
++---------+++++
----+-+++-++++-+
-+++-+
-----+
++++++
-----+
---+--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-3.317
3.317
3.317
-3.316
3.315
-3.314
3.313
-3.313
3.312
-3.311
-3.31
3.309
3.308
3.307
-3.307
-3.307
3.306
-3.305
3.305
-3.304
-3.301
-3.301
3.301
-3.3
-3.3
-3.299
-3.299
3.299
3.299
-3.299
-3.299
3.298
3.298
-3.297
3.297
3.297
-3.296
3.295
-3.295
3.295
3.294
-3.294
3.293
3.293
-3.292
3.291
3.291
-3.291
3.291
-3.289
-3.289
-3.289
-3.287
-3.286
3.286
3.286
3.285
-3.285
3.285
-3.282
-3.281
-3.281
-3.279
3.278
3.277
-3.277
3.276
-3.275
3.275
-3.273
-3.273
-3.273
3.272
-3.272
-3.271
-3.271
-3.27
-3.269
3.269
3.269
3.269
3.268
3.268
-3.267
-3.267
3.266
3.266
3.265
-3.264
3.264
-3.263
3.262
-3.261
-3.261
3.261
-3.261
-3.261
-3.261
-3.26
3.26
-3.256
-3.254
-3.254
-3.253
3.253
3.251
-3.249
-3.248
-3.248
3.247
-3.245
-3.245
-3.245
3.245
3.244
3.244
3.244
-3.243
3.243
-3.242
3.242
3.24
-3.24
-3.24
3.239
3.238
3.238
-3.238
-3.237
3.237
3.236
3.236
3.236
3.236
-3.235
-3.235
-3.235
-3.233
3.231
-3.23
-3.231
3.23
-3.228
-3.226
3.226
3.226
-3.226
3.226
-3.225
-3.226
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
9.08E-04
9.09E-04
9.10E-04
9.14E-04
9.17E-04
9.21E-04
9.24E-04
9.25E-04
9.28E-04
9.29E-04
9.33E-04
9.35E-04
9.38E-04
9.42E-04
9.43E-04
9.44E-04
9.47E-04
9.48E-04
9.51E-04
9.53E-04
9.64E-04
9.64E-04
9.64E-04
9.66E-04
9.67E-04
9.69E-04
9.69E-04
9.69E-04
9.70E-04
9.71E-04
9.71E-04
9.72E-04
9.75E-04
9.77E-04
9.78E-04
9.79E-04
9.81E-04
9.83E-04
9.84E-04
9.85E-04
9.88E-04
9.89E-04
9.90E-04
9.92E-04
9.96E-04
9.97E-04
9.98E-04
9.98E-04
9.98E-04
1.01E-03
1.01E-03
1.01E-03
1.01E-03
1.02E-03
1.02E-03
1.02E-03
1.02E-03
1.02E-03
1.02E-03
1.03E-03
1.03E-03
1.04E-03
1.04E-03
1.05E-03
1.05E-03
1.05E-03
1.06E-03
1.06E-03
1.06E-03
1.06E-03
1.06E-03
1.07E-03
1.07E-03
1.07E-03
1.07E-03
1.07E-03
1.08E-03
1.08E-03
1.08E-03
1.08E-03
1.08E-03
1.08E-03
1.08E-03
1.09E-03
1.09E-03
1.09E-03
1.09E-03
1.09E-03
1.10E-03
1.10E-03
1.10E-03
1.11E-03
1.11E-03
1.11E-03
1.11E-03
1.11E-03
1.11E-03
1.11E-03
1.11E-03
1.12E-03
1.13E-03
1.14E-03
1.14E-03
1.14E-03
1.14E-03
1.15E-03
1.16E-03
1.16E-03
1.16E-03
1.17E-03
1.17E-03
1.17E-03
1.17E-03
1.18E-03
1.18E-03
1.18E-03
1.18E-03
1.18E-03
1.19E-03
1.19E-03
1.19E-03
1.20E-03
1.20E-03
1.20E-03
1.20E-03
1.20E-03
1.20E-03
1.20E-03
1.21E-03
1.21E-03
1.21E-03
1.21E-03
1.21E-03
1.21E-03
1.22E-03
1.22E-03
1.22E-03
1.23E-03
1.24E-03
1.24E-03
1.24E-03
1.24E-03
1.25E-03
1.25E-03
1.26E-03
1.26E-03
1.26E-03
1.26E-03
1.26E-03
1.26E-03
57430
57656
50635
40279
22842
56195
21856
56812
64625
32246
50494
30083
26824
13050
28207
36528
30840
13351
61953
47
68191
4495
10306
37396
43099
19774
59726
26900
19123
46082
26433
29665
33201
16526
32175
17453
57561
2360
41565
35659
27978
65864
6221
41928
6699
26624
31223
58158
22275
16030
65875
49082
51605
66714
19189
28801
27151
25715
34069
34199
66407
17924
52751
59825
17910
57540
33448
1312
59314
36305
62918
68254
9106
13474
27642
53661
11607
53203
21768
37037
19021
62381
32218
8349
62661
7526
36485
47953
50992
32646
9632
10690
30713
12023
15292
19020
19070
822
17002
802
10811
49595
10060
5678
54495
12768
15015
50008
43559
63005
10425
63928
27297
36123
58499
38381
20134
64152
24661
3101
9148
44920
8136
10889
30907
33807
60925
1743
18727
42065
7431
29530
25235
18489
24668
14454
36707
37103
26386
18488
35031
38379
10497
30510
19229
66389
33561
24225
17847
21787
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
3189
7045
84303
9887
90462
51012
79738
5981
151648
56995
163351
80020
5990
2498
79745
25814
8436
26099
253152
51441
7290
48
55037
1119
2314
80305
2585
440689
26229
409
10268
5052
84316
10212
6632
54880
144195
80231
245812
10049
6628
47
84953
9793
28977
178
1314
58487
394
80789
151636
6647
6714
54980
8451
84660
64132
203447
132158
54097
1109
8755
6938
27304
7128
23209
57223
55634
79873
121260
84163
7874
112398
7368
4084
6817
858
57092
11218
400002
55016
80148
79058
9844
55611
10103
10121
57795
55225
57674
7073
2908
4117
2037
7323
170575
91039
51311
6617
9639
4681
7541
55959
10899
27327
84518
85364
987
410
8894
23385
57125
90423
80742
84446
10174
29889
6168
10007
125058
139596
23705
10204
2760
476
4683
317781
26047
3428
3482
23588
694
10903
84309
10635
7297
4595
9658
93349
91147
1876
3998
221079
3012
8805
6749
64761
51324
80227
5935
HNRNPH3
TGFBI
CHCHD6
SMG7
LOC90462
SLMO2
BBS10
RFC1
SGOL1
TULP4
GBP6
FOXRED2
RFX2
FTH1P10
CLIP4
ATXN10
SDPR
SZRD1
EPHX4
YTHDF2
HIRA
ACO1
PTCD3
CHKA
FLII
TRABD
GALK2
HIST2H2BF
B3GAT3
ARRB2
RAMP3
PRDX1
LSMD1
DDX39A
SNRPD1
BCOR
SLC2A14
CXorf21
CNPY4
DNAJB6
SNRPB
ACLY
MICALCL
CKAP5
MRPL42
AGL
COPA
CREBZF
ARHGAP5
INTS5
DTX3L
SOD1
SRC
C2orf42
CUL4A
CCDC62
XYLT2
NRK
GLYCTK
FAM3B
AKR1C4
ADAM6
TCF12
MOCS3
TNFAIP3
MLC1
SMEK2
KRBOX4
NUDT18
SLC15A4
GTF2IRD2
USP7
EGLN2
UGT8
MXD1
SULT1A1
CAV2
PCNP
DDX20
FLJ46363
MARCH1
PQLC1
ASPSCR1
ELMO1
OTUB1
TSPAN1
ACTR1A
FAM5B
RAVER2
RNF213
TIAL1
NR3C1
MAK
EPB41L2
UBE2D3
GIMAP1
DPP9
TLR8
SNAPC1
ARHGEF10
NBL1
ZBTB14
SULF2
JTB
TNRC6A
CNFN
ZCCHC3
LRBA
ARSA
EIF2S2
NCSTN
PLXDC1
ATP6V1E2
PRR3
BRSK1
SORBS3
GNL2
RPL37A
GNPDA1
TBC1D16
UPRT
CADM1
NUTF2
GM2A
ATP1A1
NBN
DDX51
CNTNAP2
IFI16
IGF2R
KLHDC2
BTG1
MTMR11
NUDT16L1
RAD51AP1
TYK2
MUTYH
ZNF516
SP140L
TMEM67
E2F6
LMAN1
ARL5B
HIST1H2AE
TRIM24
SSRP1
PARP12
SPG21
PAAF1
RBM3
---+--+++-+
---?-++++++
---+-----++-+----------+-----+++++++
-----+++-+++++++
+-++++
-++--++--+++-+++
++++++
--+---+-+-+
-----+
---?--+---+
++---+
++-+++
+------++++
-+---+++?+++-+++
++++-+
++++++
-----+
--++-+----+++?-+
++++++
+----++++++
-----+
++--++
++++++------++-+-----+-+++
------+-++-+---+
++++++
---+-++-+++
-----+-+-----+-+----++-+++
-+++-+
-++?++
+++++--+++----------+-++-+
++++-+
--+------+++-+++++?+-+++++
++----+--------+-+--+
++++-+
+++-++
+---++-+--++++++
--++-+
++++++
-----+
++++-+
++++-+
++-+++
++-+-+
++--++
--+--++-+++
--+--++-+++
+-++++----+-+----+--+
++-+++
++++++
-+-+----------++
+---++-++-+
-+++++
---------------+
++--+++++-+
-----+
+++--+
--++--------+---+++-+
--------+-----------+
++-+++
---+-++-+++
-------++-+
+----+
+++++-----+
-+---++++++
++++-+
+-+-------+
+-++++
-----+
---+-++-?-+
-----+
++++-+
----+++--------+--+----+--------++----+-++-+-+
--++++
---+-------
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-3.224
3.224
-3.221
3.221
-3.221
-3.22
-3.22
-3.22
-3.219
-3.219
3.219
-3.218
3.218
3.218
3.217
-3.215
-3.215
3.214
3.213
-3.212
3.211
-3.21
-3.209
-3.209
3.209
3.208
-3.208
3.207
-3.205
3.205
3.205
3.205
3.204
-3.203
-3.203
-3.202
3.202
3.201
-3.201
3.201
-3.199
3.199
3.198
-3.198
-3.197
-3.196
3.195
-3.194
-3.193
-3.193
3.192
-3.192
3.191
-3.191
-3.191
-3.191
-3.19
3.19
3.188
3.188
3.188
-3.187
-3.187
-3.186
3.185
3.185
-3.184
-3.184
3.184
3.183
3.183
-3.183
-3.182
-3.18
3.18
3.179
3.178
-3.177
-3.177
3.174
3.173
3.173
-3.173
3.172
3.171
3.17
3.17
3.17
-3.17
3.17
-3.17
3.169
3.169
-3.168
-3.167
-3.167
3.167
3.166
-3.166
-3.164
-3.164
-3.164
3.161
3.161
-3.161
-3.161
-3.16
-3.16
3.16
-3.16
3.16
-3.158
-3.158
-3.158
3.156
-3.156
-3.155
-3.155
-3.154
3.153
-3.153
3.153
-3.152
3.152
-3.15
3.149
-3.149
-3.149
3.148
3.148
-3.148
-3.146
3.146
-3.145
-3.144
3.142
-3.142
3.142
-3.14
-3.14
-3.139
-3.139
-3.138
-3.136
-3.136
-3.135
3.135
3.134
-3.134
-3.134
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.27E-03
1.27E-03
1.28E-03
1.28E-03
1.28E-03
1.28E-03
1.28E-03
1.28E-03
1.28E-03
1.29E-03
1.29E-03
1.29E-03
1.29E-03
1.29E-03
1.30E-03
1.30E-03
1.30E-03
1.31E-03
1.32E-03
1.32E-03
1.32E-03
1.33E-03
1.33E-03
1.33E-03
1.33E-03
1.34E-03
1.34E-03
1.34E-03
1.35E-03
1.35E-03
1.35E-03
1.35E-03
1.36E-03
1.36E-03
1.36E-03
1.36E-03
1.37E-03
1.37E-03
1.37E-03
1.37E-03
1.38E-03
1.38E-03
1.39E-03
1.39E-03
1.39E-03
1.39E-03
1.40E-03
1.40E-03
1.41E-03
1.41E-03
1.41E-03
1.42E-03
1.42E-03
1.42E-03
1.42E-03
1.42E-03
1.42E-03
1.42E-03
1.43E-03
1.43E-03
1.44E-03
1.44E-03
1.44E-03
1.45E-03
1.45E-03
1.45E-03
1.45E-03
1.45E-03
1.46E-03
1.46E-03
1.46E-03
1.46E-03
1.46E-03
1.47E-03
1.47E-03
1.48E-03
1.49E-03
1.49E-03
1.49E-03
1.50E-03
1.51E-03
1.51E-03
1.51E-03
1.52E-03
1.52E-03
1.52E-03
1.52E-03
1.53E-03
1.53E-03
1.53E-03
1.53E-03
1.53E-03
1.53E-03
1.53E-03
1.54E-03
1.54E-03
1.54E-03
1.54E-03
1.55E-03
1.56E-03
1.56E-03
1.56E-03
1.57E-03
1.57E-03
1.57E-03
1.58E-03
1.58E-03
1.58E-03
1.58E-03
1.58E-03
1.58E-03
1.59E-03
1.59E-03
1.59E-03
1.60E-03
1.60E-03
1.60E-03
1.61E-03
1.61E-03
1.62E-03
1.62E-03
1.62E-03
1.62E-03
1.62E-03
1.64E-03
1.64E-03
1.64E-03
1.64E-03
1.64E-03
1.64E-03
1.64E-03
1.65E-03
1.66E-03
1.66E-03
1.67E-03
1.68E-03
1.68E-03
1.68E-03
1.69E-03
1.69E-03
1.70E-03
1.70E-03
1.70E-03
1.71E-03
1.71E-03
1.72E-03
1.72E-03
1.72E-03
1.73E-03
1.73E-03
66003
648
42904
57623
62194
53259
63634
31121
6306
53335
41822
43362
20165
56393
28956
42938
29090
15293
54214
7445
24064
54733
29620
47612
48856
47460
15160
20667
3665
21489
9238
42419
56828
52978
18392
40
46448
130
41268
41671
18424
9688
58115
64231
47315
16734
48148
34524
40621
66561
65564
44997
48023
19694
40987
16652
24454
4178
19557
17772
27129
27131
56615
11613
39753
64659
51973
1171
30122
10637
13197
41462
13310
3082
37492
26809
50619
53499
62847
9313
21092
38496
39090
44816
11865
2209
32018
44599
63594
50606
33690
42693
26077
4986
12966
24150
7254
39536
45943
67989
21083
60448
29527
55610
34357
2761
25031
26368
61207
32564
13243
64150
56521
55613
34304
34750
5215
42975
46886
63870
10718
29716
13759
60406
68057
11563
52700
44646
42351
65813
57025
60551
67581
16013
48449
30934
22959
30570
40764
46235
3660
18174
52735
43318
19722
46113
31374
3487
8561
7719
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
5432
4048
1611
29942
84134
2346
1717
5959
94101
57505
115004
9435
10294
55183
22
79786
7112
5163
51720
54529
154796
340252
94121
554
23498
51491
65258
51776
80739
55015
1827
55156
79157
6885
55071
84545
6651
26054
7702
8807
347731
117584
94134
1173
122622
2619
6650
100129828
8452
55347
138639
3070
255758
84900
2805
80726
9712
4783
4916
5266
115950
27430
80128
79077
90736
7041
26512
9342
2590
7157
91942
81847
1308
240
55852
171023
81556
4190
9290
79023
23046
2354
84152
54978
6895
64170
7775
145781
205
55167
56897
6789
26001
5874
5273
6252
115704
23041
84524
57458
55571
25966
84437
2287
204
387338
64423
51090
90952
10197
64145
9735
64771
54876
65084
55727
998
7357
5742
83641
2892
488
80325
55914
326
90362
51530
115708
51069
91319
153642
65264
56893
57142
10009
64332
10384
7158
55577
6609
10501
7404
23583
22895
4644
10768
64848
84919
51118
5810
POLR2C
LTA4H
DAP
PURG
TOMM40L
FOLH1
DHCR7
RDH5
ORMDL1
AARS2
MB21D1
CHST2
DNAJA2
RIF1
ABCB7
KLHL36
TMPO
PDK1
UIMC1
ASNSD1
AMOT
ZNF680
SYTL4
AVPR2
HAAO
NOP16
MPPE1
MLTK
C6orf25
PRPF39
RCAN1
ARMC1
MFSD11
MAP3K7
C9orf40
MRPL43
SON
SENP6
ZNF143
IL18RAP
LRRTM3
RFFL
ARHGAP12
AP2M1
ADSSL1
GAS1
CAPN15
ARMCX4
CUL3
ABHD10
PTPDC1
HELLS
TCTEX1D2
RNFT2
GOT1
KIAA1683
USP6NL
NFIL3
NTRK3
PI3
ZNF653
MAT2B
TRIM46
DCTPP1
FAM104B
TGFB1I1
INTS6
SNAP29
GALNT2
TP53
NDUFAF2
RNF146
COL17A1
ALOX5
TEX2
ASXL1
VWA9
MDH1
GPR55
NUP37
KIF21B
FOSB
PPP1R1B
SLC35F6
TARBP2
CARD9
ZNF232
GCOM1
AK4
MSL2
WRNIP1
STK4
RNF167
RAB27B
SERPINB10
RTN1
EVI5L
MON2
ZC3H8
TMCC3
CNOT11
C2CD2
MSANTD4
FKBP3
AK2
NSUN4
INF2
PLLP
ESAM
PSME3
ZFYVE20
KNTC1
C6orf106
DCAF16
TMEM135
BTBD7
CDC42
UGCG
PTGS1
FAM107B
GRIA3
ATP2A2
ABTB1
ERBB2IP
AIRE
FAM110B
ZC3HC1
TRMT61A
MRPL2
DERL3
ARSK
UBE2Z
UBQLN4
RTN4
ZBTB33
NFKBIZ
BTN3A3
TP53BP1
NAGK
SMPD1
SEMA6B
UTY
SMUG1
RPH3A
MYO5A
AHCYL1
YTHDC2
PPP1R15B
UTP11L
RAD1
--+--+-++-+
++-+-+
++-+++
+-++-+
++-+++
---+-++-+++
--+-----+-+-++-+
++++-+
--+------+--++--------+---++-+-----+
--+--++--++
--+--+++++++++-+
++-+++
--+----+--+
+-+-++
+++++++-+-+-++-+
----++++?-+
+-+---+-------------+
+-+----+?-++++-+
+++-++
+++?-+
--+--++-++---+-+++?++
++-+++
+--?--+-?---------+------+--+++
---?----+-+
++++++
--+--++++-+
++-+++
+++-+++-+++-+--++-+++
----++
---+-+++++--+--++++-+
+-++-+
---+----?-+
+-+?++
+-++++
+-++++
-------------?----+---+-+---++++++-+
++-+++
++++++
++++++
-----+
+-++++
-----+
--+--++++++
-+++++
+----+
---?-+++-++
+++-++-++++
++++-+
++-+++
+-------++++++-+
-----+
---------+--++------+
-----+
----++
-+---++-++---+------+
+---+-+-?++
----+--+--++++++
++++++
-++--++-++---?+++++++
---+-++++-+
----+++++-+
+-++++
-----+
-----+
----------+
----+-+-+++
-----+-++-+
-----+-++++
++-+-+
+-----+++-+
-----++-+++
-----+++?++
++++++
++++-+
-+++-+
+----+-++-+
--++---+---
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
6376
7257
6376
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
-3.134
3.133
3.133
3.133
3.132
3.132
-3.131
3.13
-3.13
-3.129
3.128
3.128
-3.127
-3.127
-3.126
-3.125
-3.125
-3.125
-3.125
-3.124
3.125
-3.124
3.124
3.124
3.124
-3.123
-3.123
3.123
3.122
-3.122
3.122
-3.122
3.121
-3.12
-3.12
-3.119
-3.118
-3.118
-3.118
3.117
3.117
3.115
-3.113
3.113
-3.113
3.111
3.109
-3.109
-3.107
-3.107
-3.107
-3.106
3.105
-3.105
-3.103
3.102
-3.101
3.101
3.101
3.099
3.099
-3.099
3.099
-3.099
-3.099
3.099
-3.098
3.098
3.098
-3.097
-3.097
3.097
3.096
3.095
-3.095
-3.095
-3.094
-3.094
-3.094
-3.094
3.093
3.093
3.093
3.093
-3.092
3.089
-3.089
-3.089
3.088
3.087
-3.087
-3.086
3.086
-3.085
3.085
3.085
3.085
-3.085
-3.085
3.084
-3.082
-3.081
-3.081
-3.081
-3.08
-3.08
-3.08
-3.08
3.079
-3.077
-3.076
-3.076
3.075
-3.075
-3.075
3.074
3.074
-3.074
3.073
-3.071
3.071
-3.071
3.07
-3.07
3.07
3.069
-3.069
-3.069
-3.069
-3.068
-3.068
3.067
-3.067
3.067
-3.066
3.066
3.065
-3.065
3.064
-3.063
3.062
-3.062
3.06
3.06
3.059
3.057
-3.057
3.057
-3.055
-3.055
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.73E-03
1.73E-03
1.73E-03
1.73E-03
1.74E-03
1.74E-03
1.74E-03
1.75E-03
1.75E-03
1.76E-03
1.76E-03
1.76E-03
1.76E-03
1.77E-03
1.77E-03
1.78E-03
1.78E-03
1.78E-03
1.78E-03
1.78E-03
1.78E-03
1.78E-03
1.78E-03
1.78E-03
1.78E-03
1.79E-03
1.79E-03
1.79E-03
1.80E-03
1.80E-03
1.80E-03
1.80E-03
1.80E-03
1.81E-03
1.81E-03
1.81E-03
1.82E-03
1.82E-03
1.82E-03
1.82E-03
1.83E-03
1.84E-03
1.85E-03
1.85E-03
1.85E-03
1.87E-03
1.88E-03
1.88E-03
1.89E-03
1.89E-03
1.89E-03
1.90E-03
1.90E-03
1.90E-03
1.92E-03
1.93E-03
1.93E-03
1.93E-03
1.93E-03
1.94E-03
1.94E-03
1.94E-03
1.94E-03
1.94E-03
1.94E-03
1.94E-03
1.95E-03
1.95E-03
1.95E-03
1.95E-03
1.96E-03
1.96E-03
1.96E-03
1.97E-03
1.97E-03
1.97E-03
1.98E-03
1.98E-03
1.98E-03
1.98E-03
1.98E-03
1.98E-03
1.98E-03
1.98E-03
1.99E-03
2.01E-03
2.01E-03
2.01E-03
2.01E-03
2.02E-03
2.02E-03
2.03E-03
2.03E-03
2.03E-03
2.03E-03
2.04E-03
2.04E-03
2.04E-03
2.04E-03
2.04E-03
2.06E-03
2.06E-03
2.06E-03
2.07E-03
2.07E-03
2.07E-03
2.07E-03
2.07E-03
2.08E-03
2.09E-03
2.10E-03
2.10E-03
2.10E-03
2.10E-03
2.11E-03
2.11E-03
2.11E-03
2.11E-03
2.12E-03
2.13E-03
2.14E-03
2.14E-03
2.14E-03
2.14E-03
2.14E-03
2.14E-03
2.14E-03
2.15E-03
2.15E-03
2.15E-03
2.15E-03
2.16E-03
2.16E-03
2.16E-03
2.17E-03
2.17E-03
2.17E-03
2.18E-03
2.18E-03
2.19E-03
2.20E-03
2.20E-03
2.21E-03
2.21E-03
2.22E-03
2.23E-03
2.24E-03
2.24E-03
2.25E-03
2.25E-03
2627
50816
56927
62122
13503
30715
29908
20954
7859
45100
18664
14199
36827
65604
66479
54080
64312
67843
6938
4422
14711
16702
27165
38784
24648
31969
2783
9309
26339
47205
16208
55879
1529
27810
47505
6590
20576
52414
45044
26931
61891
11085
62460
22718
45805
51505
6011
16829
50785
28603
2922
39750
45655
43733
1733
29497
63810
6344
62519
54613
61089
53039
49092
8290
2134
41798
43755
38019
9018
47062
5458
48299
16302
67895
8352
7500
22619
29741
46187
22634
59259
495
34774
4481
31622
27039
9292
45494
49753
38918
24518
44328
29095
59048
39680
32359
9011
28752
27452
6859
46682
52862
56030
17632
63219
65334
10570
35489
33816
10328
65137
58557
41707
17271
60287
43219
5854
2184
9376
57571
45245
52930
49971
27134
10120
54643
14481
55092
1265
48497
21485
50768
50624
65033
44045
10663
15523
38692
22313
571
37658
155
36418
49497
57930
44415
41304
65876
5900
68470
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
51011
4835
8408
60526
8312
4023
348262
728039
51073
84950
10741
8321
6392
92597
4522
8815
10309
124402
50807
83693
26994
8446
64116
84307
83696
695
4593
26147
7105
9555
7023
9398
54551
254394
1487
58485
84172
51439
27229
64151
9445
23643
26301
83699
10092
7091
5917
598
10450
84034
165055
286103
5878
751867
55
7978
3309
9263
2051
64798
6618
9925
167153
7035
7942
7706
256435
55750
79685
10980
1408
89848
6160
1994
27071
4793
445347
5252
90522
117283
9787
5094
221154
55770
4439
8877
7165
9136
56947
3382
9931
8564
2526
152579
3429
1285
1488
84105
25941
8287
144717
4677
8986
55967
11316
2932
6624
221468
4723
84455
11083
64841
25948
79660
2995
8089
56949
27347
25825
23019
221178
10248
7175
161725
597
83480
90826
23633
79718
114785
144132
60509
372
5511
11101
9463
7789
1121
79050
2625
6491
25897
10992
80196
1355
2551
5153
288
10525
2580
FAHD2A
NQO2
ULK1
C2orf43
AXIN1
LPL
FAM195B
SSR4P1
MRPL4
PRPF38A
RBBP9
FZD1
SDHD
MOB1B
MTHFD1
BANF1
CCNO
UBALD1
ASAP1
HSDL1
RNF11
DUSP11
SLC39A8
ZNF397
TRAPPC9
BTK
MUSK
PHF19
TSPAN6
H2AFY
TFAP4
CD101
MAGEL2
MCM9
CTBP1
TRAPPC1
POLR1B
FAM8A1
TUBGCP4
NCAPG
ITM2B
LY96
GBGT1
SH3BGRL2
ARPC5
TLE4
RARS
BCL2L1
PPIE
EMILIN2
CCDC138
ZNF252P-AS1
RAB5C
SNHG3-RCC1
ACPP
MTERF
HSPA5
STK17A
EPHB6
DEPTOR
SNAPC2
ZBTB5
PAPD4
TFPI
TFEB
TRIM25
ST6GALNAC3
AGK
SAP30L
COPS6
CRY2
FCHSD1
RPL31
ELAVL1
DAPP1
NFKBIB
TRGC1
PHF1
YIF1B
IP6K3
DLGAP5
PCBP2
MICU2
EXOC2
MSH5
SPHK1
TPD52L2
RRP9
MFF
ICA1
HELZ
KMO
FUT4
SCFD2
IFI27
COL4A3
CTBP2
PCBD2
TPGS2
USP9Y
FAM109A
NARS
RPS6KA4
NDUFA12
COPE
GSK3B
FSCN1
TMEM217
NDUFV1
EFCAB7
DIDO1
GNPNAT1
KBTBD2
PPP1R3B
GYPC
YEATS4
XAB2
STK39
BACE2
CNOT1
SPATA13
POP7
TPR
OTUD7A
BCL2A1
PUS3
PRMT10
KPNA6
TBL1XR1
MBD6
DNHD1
AGBL5
ARCN1
PPP1R8
ATE1
PICK1
ZXDA
CHM
NOC4L
GATA3
STIL
RNF19A
SF3B2
RNF34
COX15
GABPA
PDE1B
ANK3
HYOU1
GAK
-----++++++
+++-++
---+-++-+++
+-++++
-+-+-+
------------+--+
-----+++++--++-+-+----+-------+
++++++
++-+++
+-+----+--+++++---+-+--?---+--++++++
-+++-+
++++-+
++-+++
-++-+-+++-+
-----+
++-+++
++-+++
-+++++
-+++-+
++++++
-+-?-+-+--+
+-------?---++-++++++
++-+++
++-+++-++-+
+++--+
---+-++-++---+-+++++-+---++++++
++++-+
-----+
+-++-+
--+-----++--++------+
-----++-+++
-----+
+-+-+++++++-++++
+++-++
+-+-++
---+-+-++++
++-+++
-----+
++--++
---+----?-++++++
-+++++
-+-+-+
-+---++++-+
++-+++
--++-++-?---+----+--++++-+
++-+++
++++-+
---+-+
--++-++++++
++-----+--+-++++
++---++++++
-----++++++
-----++-+++---+++++++
--+--+
++++-+
------+++++
+++-++
+++?++
++++++
-+---+
---+---+--+
--++-+-+--+-++++
-+-+----+------+
+---++
--+------+-+++++
-+-+++
+----+++-++
+-++++
---+---++-++-+++
+-+--+++-++
+----++-+++
---+------+
----+++++-+
-----------+++++
+---+-+-+++++-+-----+
+----+
-+++++
--+--++++-+
+---+-----+
++--++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-3.053
3.052
3.051
-3.051
3.05
3.05
3.05
-3.05
-3.049
-3.049
-3.049
3.048
-3.048
-3.047
-3.047
-3.047
3.046
3.046
-3.046
-3.045
3.044
-3.043
-3.043
-3.041
3.041
3.04
3.04
3.039
-3.038
3.038
-3.038
3.038
3.037
3.036
3.036
3.036
-3.035
3.035
-3.034
-3.034
-3.034
3.033
3.033
3.032
3.032
3.032
-3.031
3.031
-3.031
3.031
-3.031
3.03
3.028
-3.028
3.027
-3.027
-3.026
-3.026
-3.025
-3.025
3.024
-3.022
-3.021
3.021
3.019
3.019
3.018
-3.016
3.015
3.015
-3.015
3.015
-3.013
-3.012
3.012
3.01
3.009
-3.009
3.008
3.008
-3.007
-3.006
-3.004
-3.004
3.003
3.002
3.002
-3.002
-3.002
3.001
-3.001
-3.001
3
-2.998
2.997
-2.997
2.996
-2.996
2.995
-2.995
2.994
-2.994
2.994
-2.994
2.993
2.993
2.993
2.992
-2.992
-2.991
-2.99
-2.989
-2.989
2.988
-2.987
-2.987
-2.987
2.987
-2.987
-2.987
2.985
2.984
-2.984
2.984
2.983
-2.982
-2.982
2.982
-2.981
2.981
-2.98
2.977
-2.976
-2.976
-2.975
2.974
-2.974
-2.974
2.974
-2.973
-2.973
2.973
-2.972
-2.972
2.972
-2.972
2.971
-2.971
-2.97
2.969
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2.26E-03
2.27E-03
2.28E-03
2.28E-03
2.29E-03
2.29E-03
2.29E-03
2.29E-03
2.30E-03
2.30E-03
2.30E-03
2.31E-03
2.31E-03
2.31E-03
2.31E-03
2.31E-03
2.32E-03
2.32E-03
2.32E-03
2.32E-03
2.33E-03
2.34E-03
2.34E-03
2.36E-03
2.36E-03
2.36E-03
2.37E-03
2.37E-03
2.38E-03
2.38E-03
2.38E-03
2.39E-03
2.39E-03
2.39E-03
2.39E-03
2.40E-03
2.40E-03
2.41E-03
2.41E-03
2.42E-03
2.42E-03
2.42E-03
2.42E-03
2.43E-03
2.43E-03
2.43E-03
2.43E-03
2.43E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.46E-03
2.47E-03
2.47E-03
2.47E-03
2.48E-03
2.48E-03
2.49E-03
2.49E-03
2.49E-03
2.51E-03
2.52E-03
2.52E-03
2.53E-03
2.53E-03
2.54E-03
2.56E-03
2.57E-03
2.57E-03
2.57E-03
2.57E-03
2.59E-03
2.59E-03
2.59E-03
2.62E-03
2.62E-03
2.62E-03
2.63E-03
2.63E-03
2.64E-03
2.64E-03
2.67E-03
2.67E-03
2.67E-03
2.68E-03
2.68E-03
2.68E-03
2.69E-03
2.69E-03
2.69E-03
2.70E-03
2.70E-03
2.72E-03
2.73E-03
2.73E-03
2.73E-03
2.73E-03
2.74E-03
2.74E-03
2.75E-03
2.75E-03
2.75E-03
2.76E-03
2.76E-03
2.76E-03
2.77E-03
2.77E-03
2.77E-03
2.78E-03
2.79E-03
2.80E-03
2.80E-03
2.81E-03
2.81E-03
2.82E-03
2.82E-03
2.82E-03
2.82E-03
2.82E-03
2.83E-03
2.84E-03
2.85E-03
2.85E-03
2.86E-03
2.86E-03
2.86E-03
2.86E-03
2.87E-03
2.88E-03
2.89E-03
2.91E-03
2.92E-03
2.92E-03
2.93E-03
2.94E-03
2.94E-03
2.94E-03
2.94E-03
2.95E-03
2.95E-03
2.95E-03
2.96E-03
2.96E-03
2.96E-03
2.96E-03
2.97E-03
2.97E-03
2.97E-03
2.99E-03
16368
30978
46624
32320
23684
60760
45825
61826
52625
13835
14715
19844
10596
46288
17875
2402
9437
35506
7900
58939
57302
57474
31545
34254
51702
7606
51065
56256
30708
56310
34567
62215
17653
79
29222
27618
15701
48903
65988
24475
33839
58498
15534
56886
4085
29709
44095
51804
26032
33215
27566
11735
38510
35194
34012
35769
27579
13625
22715
25926
34557
48673
18823
35145
11913
51283
45860
3298
64467
4050
7983
31846
46933
6157
18082
38453
22534
43011
22694
56231
12955
43999
67686
13583
43156
44034
53644
39649
27703
52725
32497
23209
58114
51847
51932
61992
44824
52147
66404
2390
22580
6554
24334
28467
42467
42575
45194
52914
13948
21968
39098
12089
14363
39623
66770
14061
33538
49680
19163
40303
25061
38383
13990
38835
53878
61123
26528
11080
61016
63303
61535
43141
54326
658
38297
51933
20006
22387
26974
42111
8797
13982
46476
2104
33951
11392
25016
62141
68227
28542
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
7226
5245
11034
25950
11179
4173
10641
746
9899
5336
10130
60528
7915
92181
339123
114609
26024
6672
4149
51603
55758
9344
5429
64759
26263
5348
84301
57026
6497
100129828
56729
56171
27102
160
56160
339745
1978
116985
1675
84823
6729
9277
80230
1639
79034
84002
25904
3613
112752
5277
146059
55722
2946
23139
3206
29068
10010
7994
4155
51808
9448
128637
100129828
8804
5885
60673
23001
22978
55331
26254
6428
6102
55743
1387
57468
22853
7781
1014
6415
2833
126695
83861
8793
2108
55760
84447
79832
2967
25844
7024
51170
27240
7298
3714
23345
145645
54733
28986
3614
58527
6470
221472
6138
10494
5579
3308
9730
221756
5753
79001
10154
757
57175
85025
7016
9934
64599
84313
8778
6597
5983
10746
51755
7644
23518
84260
11338
161247
57184
5987
54822
3223
2979
403313
54813
22836
441191
92675
55072
81831
145389
54502
7342
5782
54556
87
3931
7027
374928
51479
TRPM2
PHB
DSTN
RWDD3
ZNF277
MCM4
NPRL2
TMEM258
SV2B
PLCG2
PDIA6
ELAC2
ALDH5A1
UBTD2
JMJD8
TIRAP
PTCD1
SP100
MAX
METTL13
RCOR3
TAOK2
POLH
TNS3
FBXO22
FXYD1
DDI2
PDXP
SKI
PDE4DIP
RETN
DNAH7
EIF2AK1
AP2A1
NDNL2
SPOPL
EIF4EBP1
ARAP1
CFD
LMNB2
SRP54
WDR46
RUFY1
DCTN1
C7orf26
B3GNT5
CNOT10
IMPA2
IFT43
PIGA
CDAN1
CEP72
GSTM2
MAST2
HOXA10
ZBTB44
TANK
KAT6A
MBP
PHAX
MAP4K4
TBC1D20
FRAS1
CREG1
RAD21
C12orf44
WDFY3
NT5C2
ACER3
OPTC
SRSF3
RP2
CHFR
CREBBP
SLC12A5
LMTK2
SLC30A3
CDH16
SEPW1
CXCR3
C1orf172
RSPH3
TNFRSF10D
ETFA
DHX32
SYVN1
QSER1
GTF2H3
YIPF3
TFCP2
HSD17B11
SIT1
TYMS
JAG2
SYNE1
C15orf43
SLC35F2
MAGEH1
IMPDH1
ABRACL
SHMT1
FGD2
RPL15
STK25
PRKCB
HSPA4
VPRBP
MGC39372
PTK6
VKORC1
PLXNC1
TMEM50B
CORO1B
TMEM60
TESK1
P2RY14
GIGYF1
VPS25
SIGLEC5
SMARCA4
RFC3
MAP3K2
CDK12
ZNF91
R3HDM1
TCHP
U2AF2
FITM1
FAM219B
TRIM27
TRPM7
HOXC6
GUCA1B
PPAPDC2
KLHL28
RHOBTB3
RNF216P1
DTD1
RNF31
NETO2
SLC38A6
RBM47
UBP1
PTPN12
ING3
ACTN1
LCAT
TFDP1
ZNF773
ANKFY1
-+-+++
-----+
++-+-+
-------++----+-++-+++
---+-++++++
+-+?-+
-++-++
-----+
--++---+-------+
-++-++
-----+
++++++
+++++-----+
-----++---+
+-++++
++-+-+
--+--++++++
--+-+-----+
++++++
++++++
+++-++
++-+++
++-+++++++-----+-+++-+++-+
++++-+
++++-+
-----+
--++--+---+
++-++++-+++
-----+
+++-++
-------+---+---++++-++++-+
----+-------++-+
++++++
+----+-++++----++++++
--++-+++-++
++-?++
++++++
-+++++-+-------+
+-++++
+-++-+
++-+-+
---+++
-----+-+-++
+-++++
++++-+
+++-++
+-+--+
-++?++
+-++++
++-+++
++------?-+-++++
-----+++++-----+
-----+
--+---+-+-+-++-+
-------++-+
-+-----++-+++-++
---+-+
++++++
-----+
-----++-+++
+-+-------+
---+++
-----+
++-+++
++++-+
------+--++---+++++++
++++++
++++++
-+---++++++
+-++++
++-+++
++++-+
++-+++
-+++++
+++--+
-------+--+++--+
-------+--+-++-++-+-+
-----+
++-+++
+++?-+
-+++++
-+-+-++++++
--+----+-------+++++---+-+++-++
++++-+
--++-+-++-+-+--+
-----+
+-+--+
--++--+---++++-+
+++++-----+
++++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
2.968
-2.968
2.968
-2.967
-2.967
-2.966
2.966
-2.966
2.964
2.964
2.963
-2.963
-2.963
-2.963
-2.963
2.962
-2.961
2.961
2.961
-2.959
-2.959
2.958
2.958
2.957
-2.955
2.953
-2.952
-2.951
2.95
2.95
2.95
2.949
2.948
2.948
-2.948
2.947
2.947
2.947
2.947
-2.947
-2.946
-2.945
2.945
2.944
-2.944
2.943
-2.943
-2.943
-2.942
2.942
2.942
-2.938
-2.938
2.937
2.937
-2.937
2.937
-2.937
2.936
-2.936
2.935
2.934
2.934
2.934
-2.933
-2.933
2.932
2.932
2.932
2.932
-2.931
2.931
2.93
2.929
2.929
2.928
2.927
2.926
2.926
-2.923
-2.922
2.922
-2.921
2.921
-2.92
-2.92
-2.92
-2.919
2.919
-2.919
2.919
-2.918
-2.918
2.918
2.916
2.914
-2.914
-2.914
2.913
-2.913
-2.913
2.913
-2.912
2.911
2.911
-2.91
-2.91
-2.909
2.909
2.909
2.908
-2.907
2.907
2.906
2.906
2.905
2.905
2.905
2.904
-2.903
-2.903
2.902
-2.902
-2.901
-2.901
2.899
-2.899
2.898
2.898
2.898
-2.896
2.896
-2.895
-2.895
-2.895
2.895
-2.894
2.893
2.892
-2.892
-2.892
2.891
-2.89
2.889
-2.889
-2.889
2.889
2.888
-2.888
2.888
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3.00E-03
3.00E-03
3.00E-03
3.00E-03
3.01E-03
3.02E-03
3.02E-03
3.02E-03
3.04E-03
3.04E-03
3.04E-03
3.04E-03
3.05E-03
3.05E-03
3.05E-03
3.06E-03
3.06E-03
3.07E-03
3.07E-03
3.09E-03
3.09E-03
3.10E-03
3.10E-03
3.10E-03
3.12E-03
3.15E-03
3.16E-03
3.17E-03
3.18E-03
3.18E-03
3.18E-03
3.19E-03
3.20E-03
3.20E-03
3.20E-03
3.20E-03
3.21E-03
3.21E-03
3.21E-03
3.21E-03
3.22E-03
3.23E-03
3.23E-03
3.24E-03
3.24E-03
3.25E-03
3.25E-03
3.25E-03
3.26E-03
3.26E-03
3.26E-03
3.30E-03
3.31E-03
3.31E-03
3.31E-03
3.32E-03
3.32E-03
3.32E-03
3.32E-03
3.32E-03
3.34E-03
3.35E-03
3.35E-03
3.35E-03
3.35E-03
3.36E-03
3.37E-03
3.37E-03
3.37E-03
3.37E-03
3.38E-03
3.38E-03
3.39E-03
3.40E-03
3.40E-03
3.41E-03
3.42E-03
3.43E-03
3.44E-03
3.46E-03
3.47E-03
3.48E-03
3.49E-03
3.49E-03
3.50E-03
3.50E-03
3.50E-03
3.51E-03
3.51E-03
3.51E-03
3.52E-03
3.52E-03
3.52E-03
3.52E-03
3.54E-03
3.56E-03
3.57E-03
3.57E-03
3.58E-03
3.58E-03
3.58E-03
3.59E-03
3.59E-03
3.60E-03
3.60E-03
3.61E-03
3.61E-03
3.62E-03
3.63E-03
3.63E-03
3.64E-03
3.65E-03
3.65E-03
3.66E-03
3.66E-03
3.67E-03
3.67E-03
3.67E-03
3.69E-03
3.69E-03
3.70E-03
3.71E-03
3.71E-03
3.72E-03
3.72E-03
3.74E-03
3.75E-03
3.76E-03
3.76E-03
3.76E-03
3.78E-03
3.78E-03
3.79E-03
3.79E-03
3.79E-03
3.80E-03
3.81E-03
3.82E-03
3.83E-03
3.83E-03
3.83E-03
3.84E-03
3.86E-03
3.86E-03
3.86E-03
3.86E-03
3.86E-03
3.87E-03
3.88E-03
3.88E-03
50311
12387
39254
12228
26993
13280
55558
66554
25901
66801
34236
35859
15048
18615
30107
57339
1894
18742
26759
51895
29146
21421
9032
11816
52473
17336
38098
67515
64259
28371
24654
59266
14869
24056
50784
42326
24101
47093
42596
49463
37870
55603
32803
3529
36240
16911
21516
45493
26698
3725
56668
42971
25144
21416
41061
44033
6954
12443
19127
17060
10822
14597
11018
11769
20025
37083
67758
52238
60809
17940
55186
66730
38005
16588
52573
20741
35978
50242
39251
16135
17678
43393
21098
1825
24377
39258
3216
57157
28060
7410
5233
11034
43070
35644
9071
18046
7672
50085
63168
26040
778
39987
43578
6322
41037
24806
67496
52694
34383
17621
9203
53075
15751
14992
61388
40623
6914
37489
17539
26992
45912
3909
28725
28978
38732
24538
39029
65424
7202
19469
58052
16433
9944
29234
54412
56556
9034
44418
12362
43155
24858
9777
65825
53213
43422
57420
51221
11473
46675
34797
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
4201
51312
154075
90141
64983
4358
375748
166647
4302
23324
2628
400966
7257
79415
23283
2131
80741
84196
4817
9099
5894
8483
51657
55201
6945
23155
3460
5973
4716
51451
10194
64282
23555
9128
3015
8906
2623
6525
221476
57633
158293
29950
92241
554203
55888
51340
153339
9493
256979
3911
60558
8074
6238
6934
5395
51604
79183
7332
125228
79908
399687
51621
55844
1345
57404
8899
84942
4061
6182
8896
54516
10956
7150
8506
3778
9422
124460
266675
27037
10000
5777
29100
51471
1632
54539
157927
5780
9910
414
8527
4552
3784
55719
7263
2246
125336
80306
161882
79047
55022
386676
79815
57542
1848
5438
9363
2968
30011
3895
80318
3052
7561
51201
100129828
84072
1810
79097
8495
808
662
1777
10762
55129
57414
10856
221718
80233
7259
96764
55179
8726
4320
5877
27232
339541
401105
3836
22872
23243
9748
9641
311
57654
84269
2286
5162
54918
28511
1889
5798
MEA1
SLC25A37
SAMD3
EFCAB11
MRPL32
MPV17
ERCC6L2
GPR125
MLLT6
MAN2B2
GATM
RGPD1
TSNAX
C17orf62
CSTF2T
EXT1
LY6G5C
USP48
NIT1
USP2
RAF1
CILP
STYXL1
MAP1S
MLX
CLCC1
IFNGR2
RENBP
NDUFB10
LCMT1
TSHZ1
PAPD5
TSPAN15
PRPF4
H2AFZ
AP1G2
GATA1
SMTN
PI16
LRRN1
FAM120AOS
SERTAD1
RCSD1
JPX
ZKSCAN7
CRNKL1
TMEM167A
KIF23
SUN3
LAMA5
GUF1
FGF23
RRBP1
TCF7L2
PMS2
PIGT
TTPAL
UBE2L3
FAM210A
BTNL8
MYO18A
KLF13
PPP2R2D
COX6C
CYP20A1
PRPF4B
WDR73
LY6E
MRPL12
BUD31
MTRF1L
OS9
TOP1
CNTNAP1
KCNMA1
ZNF264
SNX20
BEST4
TRMT2A
AKT3
PTPN6
TMEM208
NAT8
ECI1
NDUFB11
C9orf62
PTPN9
RABGAP1L
ARSD
DGKD
MTRR
KCNQ1
FAM178A
TST
FGF1
LOXHD1
MED28
ZFPM1
KCTD15
PID1
KRTAP10-9
NIPAL2
KLHL42
DUSP6
POLR2I
RAB33A
GTF2H4
SH3KBP1
KTN1
GKAP1
HCCS
ZNF14
ZDHHC2
DNAJC4
HORMAD1
DR1
TRIM48
PPFIBP2
CALM3
BNIP1
DNASE2
NUP50
ANO10
RHBDD2
RUVBL2
LINC00518
C17orf70
TSPYL1
TGS1
FAIM
EED
MMP11
RABIF
GNMT
C1orf228
FLJ42393
KPNA1
SEC31A
ANKRD28
SLK
IKBKE
ANXA11
UVSSA
CHCHD5
FKBP2
PDHB
CMTM6
NKIRAS2
ECE1
PTPRN
-+++++
+++++++-+++
++++++
--+-------+
--+-++-+-------+
+++--+
---+-+-++++
+++?++
+++-++
--+---+++-+
++---+
++-+++
-+++-+
++-+++
+++--+
++++++
-+++++
++++-+
+-++-+
++++++
+-+--+
-+++-+
++++-+
-----+
---?-+
-+++-++--------+-++++
++-+++
++-++++++++
++--++-+--+
--++++
++++++
-++--+
--+----+--+
--+-++-++-+
--++-----------+
--++-++-+++
++-+++
+-++++
-----+
++-+-+
+++++-+--------++++++
++--++
+----+
+-----+-++-------+-------+
-+-+++
---+-+
++-+++
++++++
+++-++
--+--+---++
+-++++
--+--++++-+
++-+-+
++++++
-++-++++-++
+-++++
++--+-+++-+
---+-+
++-+++
+-+-++
++++++
++--++
++++++
--+--++--++
----+++++++
++++++
+--+-+
--+?-+
++-+++
+++?-+
--++-++-+++
++++++
+----+
-+++++
-----+
----------+
-+---+-+---++----+?++
--++++-++----+-+
+-++++
+-+--+-+-++
--++-+
----+---+-++++++
++++++
--++++
++--++
-+---+
++++++
-----+
+--?-----+---+-----------+
+-++++
+-++++
-----+
++++++
+-++++
-----+
+-+--+-+++-----+
+++--+
++-+++
-+++++
---+----+-+
+-+-++
-+++-+
+-++++
++--++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
2.888
2.888
2.887
2.886
-2.886
-2.885
-2.884
-2.883
-2.882
2.882
-2.882
2.881
2.881
2.881
-2.881
2.88
2.88
2.88
2.879
2.879
2.878
2.878
2.878
2.877
2.876
2.875
2.874
2.873
2.873
-2.872
-2.872
-2.872
-2.872
-2.871
2.871
2.869
2.869
2.869
2.869
2.868
2.868
2.868
2.868
-2.867
-2.867
-2.867
2.866
-2.866
-2.866
-2.865
-2.865
2.865
2.865
2.865
-2.865
2.864
2.863
-2.862
-2.861
2.861
2.861
-2.861
-2.86
-2.86
-2.858
-2.858
-2.858
2.858
-2.857
2.857
2.857
2.857
-2.855
2.855
2.855
-2.854
2.852
2.852
2.851
-2.85
2.85
2.849
2.848
2.848
-2.848
2.848
2.847
2.847
2.847
2.846
-2.845
2.845
-2.844
2.844
2.842
2.842
-2.842
2.842
2.841
-2.841
2.839
2.838
-2.838
2.837
-2.837
-2.836
-2.835
-2.834
-2.834
-2.833
2.832
-2.832
-2.83
-2.83
2.83
-2.829
2.829
-2.829
-2.829
-2.829
2.826
2.826
2.826
2.825
-2.824
2.824
-2.824
-2.824
-2.823
-2.821
-2.821
-2.82
2.819
2.819
-2.818
2.816
2.816
-2.815
-2.813
2.812
-2.811
2.81
2.81
2.81
-2.809
-2.809
2.809
2.808
2.808
2.807
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3.88E-03
3.88E-03
3.89E-03
3.90E-03
3.90E-03
3.91E-03
3.92E-03
3.94E-03
3.95E-03
3.95E-03
3.95E-03
3.96E-03
3.96E-03
3.96E-03
3.97E-03
3.97E-03
3.98E-03
3.98E-03
3.98E-03
3.99E-03
4.00E-03
4.01E-03
4.01E-03
4.02E-03
4.03E-03
4.04E-03
4.05E-03
4.07E-03
4.07E-03
4.08E-03
4.08E-03
4.08E-03
4.09E-03
4.09E-03
4.09E-03
4.11E-03
4.12E-03
4.12E-03
4.12E-03
4.13E-03
4.13E-03
4.13E-03
4.13E-03
4.15E-03
4.15E-03
4.15E-03
4.15E-03
4.16E-03
4.16E-03
4.16E-03
4.17E-03
4.17E-03
4.17E-03
4.17E-03
4.17E-03
4.18E-03
4.20E-03
4.21E-03
4.22E-03
4.22E-03
4.23E-03
4.23E-03
4.23E-03
4.24E-03
4.26E-03
4.27E-03
4.27E-03
4.27E-03
4.27E-03
4.27E-03
4.27E-03
4.28E-03
4.30E-03
4.30E-03
4.30E-03
4.32E-03
4.34E-03
4.34E-03
4.36E-03
4.37E-03
4.37E-03
4.38E-03
4.39E-03
4.40E-03
4.40E-03
4.40E-03
4.41E-03
4.41E-03
4.42E-03
4.42E-03
4.44E-03
4.44E-03
4.45E-03
4.45E-03
4.48E-03
4.49E-03
4.49E-03
4.49E-03
4.50E-03
4.50E-03
4.53E-03
4.54E-03
4.54E-03
4.55E-03
4.56E-03
4.56E-03
4.58E-03
4.59E-03
4.60E-03
4.61E-03
4.62E-03
4.63E-03
4.65E-03
4.66E-03
4.66E-03
4.66E-03
4.67E-03
4.67E-03
4.68E-03
4.68E-03
4.71E-03
4.71E-03
4.72E-03
4.73E-03
4.74E-03
4.74E-03
4.74E-03
4.75E-03
4.76E-03
4.78E-03
4.78E-03
4.80E-03
4.81E-03
4.82E-03
4.84E-03
4.86E-03
4.87E-03
4.87E-03
4.90E-03
4.92E-03
4.93E-03
4.96E-03
4.96E-03
4.96E-03
4.97E-03
4.97E-03
4.97E-03
4.98E-03
4.99E-03
4.99E-03
44343
27355
35420
36947
10703
38285
39873
3024
21133
5609
58191
58964
7905
16034
8228
43551
49376
53716
32952
50921
12436
67441
5228
7160
34672
30098
32618
28107
32242
5684
56532
5895
4203
4436
44870
5444
30399
67474
67090
40113
7208
13437
51484
28505
19982
52354
65079
53419
24219
7557
16353
4409
44651
50048
31453
5348
31704
11911
49871
57257
12715
37916
20465
54580
40847
48901
12469
44722
49706
67681
32708
51846
5392
52301
25122
36763
20014
35996
16359
6839
49853
44145
22817
18069
42781
45732
44089
38615
9162
41955
52058
24958
55182
32991
60246
20704
33828
28343
50522
21380
68064
66020
61601
57432
26431
9834
21379
56507
18691
39696
555
1615
35637
14685
22549
10536
57992
30426
8975
16606
53808
8025
4041
59673
39760
3555
36931
41794
53719
11269
40629
34340
35712
8637
32243
44497
39740
42422
61209
8785
51981
61417
36960
23193
26576
49470
16653
28161
48007
18956
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
57415
1964
140710
203054
55858
26585
84300
27252
8289
57678
90135
119032
83955
147807
92370
84890
27183
79730
51287
7770
133619
27178
64395
55131
51005
55840
55227
56063
79830
56852
9391
8605
5514
54947
29948
51042
51031
131474
8514
7136
27241
28968
2643
83933
6450
51218
79675
23746
10244
149840
51009
3108
1589
64080
22885
55975
10107
8884
23660
442213
51094
220323
10046
132241
5119
63892
3161
11063
54780
84875
1400
5293
51102
10866
3149
11070
55074
7392
1677
6829
9734
93587
835
5799
112724
91614
9728
22869
910
80177
2520
9589
9550
57158
211
23047
130916
116988
148268
23557
9453
8916
57536
8915
51163
2734
257364
51390
10245
22850
481
9519
80153
7329
9536
100129828
1347
6721
10011
5791
1107
55325
1906
9367
11176
8439
57292
53829
55279
57731
55315
2584
7072
23646
1491
6642
81532
55120
100129828
2342
7148
1454
84312
2770
55790
8654
830
4059
759
64429
C3orf14
EIF1AX
SOGA1
ADCK5
TMEM165
GREM1
MNF1
KLHL20
ARID1A
GPAM
BTBD6
C10orf32
NACAP1
ZNF524
ACPL2
ADO
VPS4A
NSUN7
COA4
ZNF227
PRRC1
IL37
GMCL1
RBM28
AMDHD2
EAF2
LRRC1
TMEM234
ZMYM1
RAD18
CIAO1
PLA2G4C
PPP1R10
LPCAT2
OSGIN1
ZNF593
GLOD4
CHCHD4
KCNAB2
TNNI2
BBS9
SLC6A16
GCH1
HDAC10
SH3BGR
GLRX5
FASTKD1
AIPL1
RABEPK
C20orf196
DERL2
HLA-DMA
CYP21A2
RBKS
ABLIM3
KLHL7
TRIM10
SLC5A6
ZKSCAN5
PTCHD4
ADIPOR1
OAF
MAMLD1
RPL32P3
CHMP1A
THADA
HMMR
SOX30
NSMCE4A
PARP10
CRMP1
PIK3CD
MECR
HCP5
HMGB3
TMEM115
OXR1
USF2
DFFB
SUPT5H
HDAC9
TRMT10A
CASP2
PTPRN2
RDH13
DEPDC7
SECISBP2L
ZNF510
CD1B
MYCT1
GAST
WTAP
ATP6V1G1
JPH2
ALAS1
PDS5B
MTERFD2
AGAP3
ZNF570
SNAPIN
GGPS1
HERC3
KIAA1328
BCL10
DBR1
GLG1
SNX33
AIG1
TIMM17B
ADNP2
ATP1B1
TBPL1
EDC3
UBE2I
PTGES
FCRL3
COX7A2
SREBF2
SRA1
PTPRE
CHD3
UFSP2
EDN1
RAB9A
BAZ2A
NSMAF
KIR2DL2
P2RY13
ZNF654
SPTBN4
SLC29A3
GALK1
TIA1
PLD3
CTH
SNX1
MOB2
FANCL
NXPH2
FNTB
TNXB
CSNK1E
BRMS1L
GNAI1
CSGALNACT1
PDE5A
CAPZA2
BCAM
CA1
ZDHHC6
+++++--+--++-+++
++-+++
+-++++
+++-++
---+------+
-----+
-----++-+++
-+++++
--+--+
++-+-+
--+--+
+----++-+++
++++++
---+---+----+--+++--+
--++-------+++++
----------++++-+
+-----+-+------+
-+++++
+++--+
+++-++
++++-+
-----+
+-------?-++-+-+
+-++-+
---+--+---+
+-++++
-++--+
--+-+++-+++-+--++++-+
--+------+-+++--+-+++
+++-++
++++++
+++++-++-++
++-++-----+
++-+-+
++++++
+++++-+++-+
++++++
--++-+
++++++
----+-++++++++-+
----+++++-+
++-+++
-----+
-------++++
+--+++
++++-+
--+--++-+++
-----+
-+---+
++++++
--+-++----+
+++--+
-----+
----++-------+---+--+--+-+++-++
++++++
---+-+--+++
--++++
+-++--+-+-+-+-++
-+----+++++
---+-+-++-+
-----++++++
+-------+-+
++-+-+
+-+--++++++
---++++++++
+-+---+-+------+
++++-+
++-?++
-+++++
++++++
++++-+
+-++-+
+------+-------++-+-+
+++?++
----++++++++++++
+-++-++-?++
-+++-+
+-+-++
-----++-+-+
----------+
++-+++-++++
+++?++
++--++
++-?++
++-+++
---++++-+-+-+--++-+++-+++++--++
++++++-+?--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
2.807
-2.806
2.805
2.803
2.803
2.803
-2.802
-2.802
-2.801
-2.801
2.8
2.8
-2.8
2.799
-2.798
-2.798
2.798
2.797
-2.796
-2.796
-2.796
2.795
-2.795
-2.795
2.794
-2.794
-2.793
2.793
-2.793
-2.792
-2.791
2.791
2.79
2.79
2.79
-2.789
-2.789
-2.788
2.787
2.787
-2.787
-2.787
2.785
2.784
-2.784
2.784
-2.783
2.782
-2.781
-2.781
-2.781
2.781
2.781
2.781
2.78
2.779
2.778
-2.778
2.776
2.776
2.775
2.776
2.775
2.775
2.775
-2.774
-2.774
2.774
-2.773
2.773
2.772
-2.771
-2.77
2.77
2.769
2.769
-2.766
2.766
-2.766
-2.766
2.765
-2.765
-2.765
2.765
-2.765
-2.764
-2.764
-2.762
-2.762
-2.762
2.762
2.761
-2.761
2.76
2.76
-2.76
-2.759
2.757
-2.756
2.756
-2.756
2.755
-2.755
2.754
-2.754
-2.754
2.754
-2.751
2.75
-2.75
2.749
-2.749
-2.748
-2.748
2.747
2.746
2.745
2.745
2.743
2.743
-2.743
-2.743
-2.742
2.741
2.741
-2.741
2.74
2.74
-2.74
2.74
2.739
2.738
-2.737
2.737
-2.737
-2.737
2.736
2.736
2.736
2.735
2.734
2.733
-2.733
-2.732
-2.732
2.732
2.731
2.731
2.731
-2.731
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
5.00E-03
5.02E-03
5.03E-03
5.06E-03
5.06E-03
5.07E-03
5.07E-03
5.08E-03
5.09E-03
5.10E-03
5.11E-03
5.12E-03
5.12E-03
5.12E-03
5.14E-03
5.14E-03
5.14E-03
5.16E-03
5.17E-03
5.17E-03
5.18E-03
5.19E-03
5.19E-03
5.19E-03
5.20E-03
5.20E-03
5.22E-03
5.22E-03
5.22E-03
5.24E-03
5.25E-03
5.25E-03
5.27E-03
5.27E-03
5.27E-03
5.29E-03
5.29E-03
5.30E-03
5.32E-03
5.32E-03
5.32E-03
5.33E-03
5.35E-03
5.37E-03
5.37E-03
5.38E-03
5.39E-03
5.40E-03
5.41E-03
5.42E-03
5.42E-03
5.42E-03
5.43E-03
5.43E-03
5.43E-03
5.46E-03
5.47E-03
5.47E-03
5.50E-03
5.50E-03
5.51E-03
5.51E-03
5.52E-03
5.52E-03
5.53E-03
5.53E-03
5.54E-03
5.54E-03
5.55E-03
5.55E-03
5.57E-03
5.58E-03
5.61E-03
5.61E-03
5.62E-03
5.63E-03
5.67E-03
5.67E-03
5.68E-03
5.68E-03
5.69E-03
5.69E-03
5.69E-03
5.70E-03
5.70E-03
5.70E-03
5.71E-03
5.74E-03
5.74E-03
5.75E-03
5.75E-03
5.77E-03
5.77E-03
5.78E-03
5.78E-03
5.78E-03
5.80E-03
5.84E-03
5.85E-03
5.85E-03
5.85E-03
5.86E-03
5.87E-03
5.88E-03
5.88E-03
5.88E-03
5.89E-03
5.94E-03
5.96E-03
5.97E-03
5.97E-03
5.99E-03
5.99E-03
6.00E-03
6.01E-03
6.02E-03
6.04E-03
6.04E-03
6.08E-03
6.08E-03
6.09E-03
6.10E-03
6.10E-03
6.12E-03
6.13E-03
6.14E-03
6.14E-03
6.15E-03
6.15E-03
6.15E-03
6.17E-03
6.19E-03
6.19E-03
6.19E-03
6.20E-03
6.21E-03
6.22E-03
6.22E-03
6.23E-03
6.24E-03
6.26E-03
6.28E-03
6.28E-03
6.29E-03
6.29E-03
6.30E-03
6.31E-03
6.32E-03
6.32E-03
6.32E-03
13858
28676
17299
7587
58801
40386
62207
34182
40941
19727
4372
44373
19813
14314
65209
42732
187
39084
14834
58570
14955
1144
63065
43243
37807
67992
57903
35372
17567
66877
36969
66322
11588
51447
29046
6681
47664
43522
46467
47363
60949
68011
20784
59680
61813
63495
41937
37851
20435
45324
68034
6460
30021
26958
8668
11295
65379
17684
15127
40868
47903
9960
66891
48369
42527
43896
29805
30699
32714
23170
34864
22528
67457
56585
38008
18458
21446
11155
15909
7150
15273
22386
65706
13551
3743
39235
39646
24268
19912
57955
42236
66443
13725
37276
40766
65080
61423
21770
11309
23322
5449
45501
41667
33155
10947
30591
15746
51212
14651
33985
54719
66735
11294
15149
36970
43797
36757
41745
24723
14630
59830
16007
50618
39467
42966
23343
41185
65753
58345
66373
13468
33199
46158
14629
36252
31389
29085
53162
63947
24922
16001
44319
9176
26474
47147
19220
53327
57949
50582
66380
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
123879
8890
29937
5366
64411
10548
317716
22820
10855
80761
401466
10211
23064
9745
2912
138428
51438
8900
80071
64096
53373
80349
91056
80124
23399
9371
51065
171392
578
389197
10008
9885
54487
23210
56979
925
3566
6709
200634
468
8795
23177
23216
348093
1315
55327
348738
9848
3094
129685
4853
10038
10476
50619
254263
5601
2776
6877
54807
122704
79081
125476
6049
946
7840
7539
60343
91833
5933
5376
55145
54436
80896
378465
113179
79630
2200
5664
205428
9765
29761
54468
513
79837
27131
9459
51100
339398
7726
118881
30968
124411
196410
10542
23080
114044
23626
7248
10195
100129828
5790
10898
56994
10213
283742
9091
8470
2027
51430
84816
64149
4337
23644
84818
83787
55731
58505
114882
3551
284370
51249
10200
6715
2047
6665
79728
84947
11243
9373
10659
8708
92906
2846
2182
80204
23131
728294
283420
79713
29947
51127
92017
94015
3145
7626
5128
3787
6575
6563
4351
DCUN1D3
EIF2B4
NENF
PMAIP1
ARAP3
TM9SF1
BPIFA4P
COPG1
HPSE
UPK3B
C8orf59
FLOT1
SETX
ZNF536
GRM2
PTRH1
MAGEC2
CCNA1
CCDC15
GFRA4
TPCN1
WDR61
AP5B1
VCPIP1
CTDNEP1
KIF3B
RPS27L
ZNF675
BAK1
C4orf50
KCNE3
OSBPL2
DGCR8
JMJD6
PRDM9
CD8A
IL4R
SPTAN1
KRTCAP3
ATF4
TNFRSF10B
CEP68
TBC1D1
RBPMS2
COPB1
LIN7C
C2orf48
MFAP3L
HINT1
TAF8
NOTCH2
PARP2
ATP5H
DEF6
CNIH2
MAPK9
GNAQ
TAF5
ZNF586
MRPL52
C11orf48
INO80C
RNF6
SIGLEC6
ALMS1
ZFP37
FAM3A
WDR20
RBL1
PMP22
THAP1
SH3TC1
NPL
HSN2
ADAT3
C1orf54
FBN1
PSEN2
C3orf58
ZFYVE16
USP25
MIOS
ATP5D
PIP4K2C
SNX5
ARHGEF6
SH3GLB1
LINGO4
TRIM26
COMTD1
STOML2
ZNF720
METTL7B
LAMTOR5
AVL9
MCM3AP-AS1
SPO11
TSC1
ALG3
ITGB6
PTPRCAP
CPSF4
CHPT1
PSMD14
FAM98B
PIGQ
SORBS2
ENO3
SUCO
RTN4IP1
C17orf75
MOCS1
EDC4
IL17RC
ARMC10
FAM222B
OSTC
OSBPL8
IKBKB
ZNF615
TMEM69
MPHOSPH6
SRD5A1
EPHB1
SOX15
PALB2
SERAC1
PMF1
PLAA
CELF2
B3GALT1
HNRNPLL
LPAR4
ACSL4
FBXO11
GPATCH8
D2HGDH
CLEC9A
IGFLR1
DNMT3L
TRIM17
SNX29
TTYH2
HMBS
ZNF75D
CDK17
KCNS1
SLC20A2
SLC14A1
MPI
+++-++
---+-+
++-+++
--+--+++-++
-+++-+
-+-+++
+++--+
+-++++
++++++
---+-+++-++
-++--+++-++
++++++
+++-++
++++++
+-++++
--+---+++++
---+----+++++?-+
+-+++-+-?-++-+++
++-++-++-+-+++++
-+++++
--++-+
+++--+
++--++
++++-+
++-+++
-+---+
+----++--+--+--++++-+
++--++
-----+++--+
++-+++-++---++-++-+++
+-+-+---++---+++
+-++++
--------+----?-+
-+--++
-----+-+++--+-----?----+--+------+---++++++--+
+---++-------+---+--++-?-+-++++
--+?----+-+
+-++-+
++-+++
++-+-+
---?--+-+-+
++-?++
--++-+++++--+-----+------+
++++-+
--+++---+-+-+++-+---++--++
++-+-+
----+-+-+-+-++++
+-++++
++++++
-----++++++
------+---+++?++
-+---+
-----+
+++++-------+-+++-+++
+-++++
-+-+---++----+-----------+
-----+
+++-++
---+-+
+---+----++
--++-++++-+
----+---+---++-+-++-+
--+--++++-+
+----+++-++
++++++
+-++-+-+--+
-+++++
++++-+
-+---+-+?++
+-+-----+------+
--+---+++++
+++?++
++++++
---?-+--+++
++-+++----+---------+
---+-+++++----+-
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
2.73
-2.729
2.729
-2.728
2.728
2.727
2.726
2.723
2.723
2.723
-2.722
2.721
-2.72
2.72
2.72
2.719
2.719
2.719
-2.717
2.716
-2.716
-2.716
2.715
2.714
-2.713
2.713
2.713
-2.713
2.712
2.712
2.712
2.711
2.711
2.711
2.711
-2.71
-2.71
-2.71
-2.71
2.71
2.709
-2.709
2.707
2.707
-2.707
-2.706
2.706
-2.705
-2.705
2.705
2.705
-2.705
-2.703
-2.703
2.702
-2.7
2.7
-2.7
-2.699
-2.699
-2.698
-2.696
-2.696
2.696
-2.696
-2.694
-2.694
-2.693
-2.692
2.692
-2.691
2.69
2.689
2.689
2.689
-2.689
2.688
2.686
-2.685
2.685
-2.685
-2.684
-2.683
2.682
-2.682
-2.682
2.682
-2.682
2.681
2.681
-2.68
-2.68
2.68
2.678
2.678
-2.677
2.676
-2.676
-2.675
2.675
-2.674
-2.672
2.672
-2.671
-2.67
2.67
2.669
-2.668
-2.668
-2.667
-2.667
-2.667
-2.667
2.667
-2.666
-2.665
-2.664
-2.664
2.663
-2.663
-2.663
-2.663
2.662
-2.661
2.66
-2.66
2.66
2.659
-2.658
2.658
2.657
2.657
-2.657
2.657
-2.656
-2.656
-2.656
-2.656
2.656
2.656
2.655
-2.655
2.655
2.655
-2.654
-2.653
-2.653
-2.65
2.65
-2.65
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
6.32E-03
6.35E-03
6.36E-03
6.36E-03
6.37E-03
6.40E-03
6.41E-03
6.46E-03
6.46E-03
6.47E-03
6.48E-03
6.50E-03
6.52E-03
6.53E-03
6.53E-03
6.54E-03
6.54E-03
6.56E-03
6.58E-03
6.60E-03
6.61E-03
6.61E-03
6.63E-03
6.65E-03
6.66E-03
6.66E-03
6.67E-03
6.67E-03
6.68E-03
6.68E-03
6.70E-03
6.70E-03
6.70E-03
6.70E-03
6.72E-03
6.72E-03
6.73E-03
6.73E-03
6.74E-03
6.74E-03
6.74E-03
6.75E-03
6.78E-03
6.79E-03
6.79E-03
6.80E-03
6.81E-03
6.82E-03
6.82E-03
6.83E-03
6.83E-03
6.84E-03
6.86E-03
6.86E-03
6.89E-03
6.93E-03
6.93E-03
6.94E-03
6.96E-03
6.96E-03
6.97E-03
7.02E-03
7.02E-03
7.02E-03
7.03E-03
7.06E-03
7.06E-03
7.07E-03
7.10E-03
7.10E-03
7.13E-03
7.15E-03
7.17E-03
7.17E-03
7.17E-03
7.18E-03
7.18E-03
7.24E-03
7.25E-03
7.25E-03
7.26E-03
7.27E-03
7.29E-03
7.31E-03
7.31E-03
7.32E-03
7.32E-03
7.33E-03
7.34E-03
7.35E-03
7.36E-03
7.36E-03
7.37E-03
7.41E-03
7.41E-03
7.42E-03
7.45E-03
7.46E-03
7.47E-03
7.48E-03
7.49E-03
7.54E-03
7.55E-03
7.56E-03
7.58E-03
7.59E-03
7.61E-03
7.62E-03
7.63E-03
7.64E-03
7.65E-03
7.65E-03
7.66E-03
7.66E-03
7.67E-03
7.69E-03
7.71E-03
7.72E-03
7.74E-03
7.75E-03
7.75E-03
7.75E-03
7.77E-03
7.80E-03
7.80E-03
7.81E-03
7.82E-03
7.84E-03
7.86E-03
7.86E-03
7.87E-03
7.87E-03
7.88E-03
7.88E-03
7.90E-03
7.90E-03
7.90E-03
7.91E-03
7.91E-03
7.91E-03
7.92E-03
7.92E-03
7.92E-03
7.93E-03
7.96E-03
7.97E-03
7.98E-03
8.04E-03
8.05E-03
8.05E-03
10079
46591
33025
47933
12020
48681
61319
24775
41358
25941
45352
37619
68478
61682
24384
23434
46785
21692
29584
977
60455
53692
68035
42579
1984
10203
68248
21107
61729
18772
47024
30281
24162
24395
41921
56348
6785
12493
25844
6535
42130
30044
36606
12214
32816
37723
49710
25511
3565
24324
16037
23273
31893
21519
28812
30385
34395
3158
25222
24583
36595
31547
18473
53968
38630
15911
3705
18068
37661
61458
59702
17397
15728
32626
9457
42434
897
57211
4804
59182
14090
10813
63373
12022
28419
17306
48362
38369
36013
52447
46012
30163
36522
57196
41239
16067
35213
53026
68498
57653
13104
42669
52426
11571
43440
55762
3828
35949
58577
57671
23728
54436
35947
41521
26000
21324
52543
65085
56062
58718
62313
28072
54484
15477
47866
40661
38275
26494
53628
14205
54562
53989
58571
36239
32746
49009
20722
52621
41936
45613
64037
29162
37319
63131
52071
27649
15521
32009
34865
19018
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
51068
23016
10788
84247
375444
1874
79856
51465
4330
170394
51537
10775
23234
2046
84885
10749
7812
64770
23659
64221
80176
5187
125206
4299
8737
116988
5496
7039
57003
90288
6793
84858
114907
84294
55783
59307
51715
134957
29081
9715
51290
4520
100008589
8945
1209
55277
10335
79039
11331
138724
90427
84248
346689
3795
55591
10994
151195
83460
4600
3315
59285
10531
55863
11152
207
3958
84874
4055
51267
7461
84060
402176
11344
114790
23063
5608
1108
10806
84765
7504
11240
9697
9158
145508
8723
153222
2872
305
22913
81558
112936
157769
837
84971
80833
57120
22884
8170
81628
2564
29985
55620
999
11234
23253
26255
64840
283212
25980
7020
8909
151306
79627
81844
2011
1292
1826
3046
25778
54971
684
51763
26027
30008
51111
11339
22806
2542
84287
5253
55699
54925
55621
11200
8772
3420
4624
93343
9958
7292
91050
121441
6560
84331
221120
25800
10975
4720
63933
10201
NMD3
EXOSC7
IQGAP2
LDOC1L
C5orf34
E2F4
SNX22
UBE2J1
MN1
PWWP2B
MTFP1
POP4
DNAJC9
EPHA8
ZDHHC12
KIF1C
CSDE1
CCDC14
PLA2G15
ROBO3
SPSB1
PER1
SLC5A10
AFF1
RIPK1
AGAP3
PPM1G
TGFA
CCDC47
EFCAB12
STK10
ZNF503
FBXO32
UTP23
FTSJD1
SIGIRR
RAB23
STXBP5
METTL5
FAM131B
ERGIC2
MTF1
RNA28S5
BTRC
CLPTM1
FGGY
MRVI1
DDX54
PHB2
C9orf131
BMF
FYTTD1
KLRG2
KHK
VEZT
ILVBL
CCNYL1
EMC6
MX2
HSPB1
CACNG6
PITRM1
TMEM126B
WDR45
AKT1
LGALS3
ZNF514
LTBR
CLEC1A
CLIP2
RBM48
RPL21P44
TWF2
STK11IP
WAPAL
MAP2K6
CHD4
SDCCAG8
ZNF577
XK
PADI2
TRAM2
FIBP
CEP128
SNX4
CREBRF
MKNK2
ANXA2P3
RALY
FAM117A
VPS26B
FAM91A1
CASP4
ATG4D
APOL3
GOPC
WDR37
SLC14A2
TSC22D4
GABRE
SLC39A3
STAP2
CDH1
HPS5
ANKRD12
PTTG3P
PORCN
KLHL35
AAR2
TFAP2A
ENDOU
GPBAR1
OGFRL1
TRIM56
MARK2
COL6A2
DSCAM
HBE1
DSTYK
BANP
BST2
INPP5K
ACOT11
EFEMP2
SUV420H1
OIP5
IKZF3
SLC37A4
ZDHHC16
PHF2
IARS2
ZSCAN32
TRMT1
CHEK2
FADD
IDH3B
MYH6
MVB12A
USP15
TNFSF4
CCDC149
NEDD1
SLC12A4
FAM195A
ALKBH3
SLC39A6
UQCR11
NDUFS2
MCUR1
NME6
--+-----+-+
++--++
++-+++
-+--+++++++
----++-+--+++-++
-+-+++
-----+
+-++-+
---++++++++
++++-+
-+++++
---+-+---++--+-+
-----+
++--++
--++++
+-++-+
+-++-+
++--++
++-+-+
-----+
+-++-+
--+--++-+++
++--++
--++-+
--++++
---++--+?-++---+
-+-+-+-+--+
-----+++--+
+-+?-+++++++-+++
----+++-?++
-+++++
++++++
---+-+
-----+
+-++++
-+-+-+
--+--+--+++
++-+++
---+------+
-+++++
-+++++
++++++
-----+
++++-+
--------++++-+++++?-+
+++++--++-++++-+
--+?++
++-+++
--+--++++-+
-++-++
++-+++
--+-++-+--+
-+--+-+-+----++++++++++--+
+--+-+
++-+++
+------++-+++++-+---+-++++
-+--++
++++++++--+
+-++++
++++-+++-++
-------+--++--++
++-+++
+++--+
++-?++
++-?++
+++++----+---?-+-+--++-+++
++++-+
++-++---?++
+++--+
-+-+++
-+-+-+
--+?-+
-++--+
+-++++
++-+-+
++++++
++++++
++--++
-----+
-+++++
++++++
+-++++
+-+--+
--+++---+-----++---------+-+-++
-----+
-----+
---+---++-++++++
-----+
+++-++
-+++-+
+-+--+
+++++++++++
--+--++-+++
--++----+++-+----+--+-++-+
+++++-+++-+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-2.65
-2.649
2.648
2.648
-2.648
2.647
-2.647
-2.647
2.646
2.645
-2.645
2.645
-2.645
2.645
2.643
2.642
-2.642
-2.641
2.641
-2.641
2.64
2.64
2.64
2.64
2.64
2.639
-2.639
2.639
-2.639
2.639
2.638
2.637
2.636
-2.636
-2.636
2.635
-2.635
2.635
-2.633
2.633
-2.632
2.632
2.632
-2.632
2.631
2.631
2.63
-2.63
-2.63
2.629
2.629
-2.629
2.628
2.628
-2.626
-2.626
2.626
2.626
2.626
-2.625
2.625
-2.624
-2.624
2.624
2.624
2.624
-2.623
2.623
2.623
2.622
-2.622
2.622
2.621
2.621
-2.62
2.618
-2.618
-2.617
-2.617
2.617
2.616
2.615
2.615
-2.615
-2.615
2.614
-2.613
2.613
2.612
2.612
2.612
2.611
2.611
2.611
-2.61
-2.61
2.609
2.609
2.609
2.608
2.608
2.608
-2.608
-2.608
-2.607
2.607
2.607
2.607
-2.607
2.605
2.605
2.605
2.605
2.605
2.604
2.604
2.603
2.603
2.602
-2.601
2.6
2.6
2.6
2.6
-2.6
-2.6
-2.597
-2.597
-2.597
2.596
-2.596
-2.595
-2.594
-2.594
2.594
-2.593
2.592
2.591
2.591
2.59
2.589
-2.589
2.588
-2.588
-2.587
-2.587
-2.587
2.586
2.586
2.586
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
8.06E-03
8.07E-03
8.09E-03
8.10E-03
8.11E-03
8.11E-03
8.12E-03
8.13E-03
8.14E-03
8.16E-03
8.16E-03
8.17E-03
8.17E-03
8.17E-03
8.21E-03
8.24E-03
8.25E-03
8.26E-03
8.26E-03
8.27E-03
8.28E-03
8.29E-03
8.30E-03
8.30E-03
8.30E-03
8.31E-03
8.31E-03
8.32E-03
8.32E-03
8.32E-03
8.34E-03
8.37E-03
8.38E-03
8.39E-03
8.39E-03
8.40E-03
8.41E-03
8.42E-03
8.45E-03
8.48E-03
8.48E-03
8.49E-03
8.49E-03
8.50E-03
8.51E-03
8.52E-03
8.53E-03
8.53E-03
8.54E-03
8.56E-03
8.57E-03
8.58E-03
8.58E-03
8.59E-03
8.63E-03
8.64E-03
8.64E-03
8.64E-03
8.65E-03
8.67E-03
8.67E-03
8.68E-03
8.69E-03
8.69E-03
8.70E-03
8.70E-03
8.71E-03
8.72E-03
8.73E-03
8.73E-03
8.73E-03
8.75E-03
8.76E-03
8.77E-03
8.78E-03
8.84E-03
8.85E-03
8.86E-03
8.87E-03
8.87E-03
8.89E-03
8.91E-03
8.91E-03
8.92E-03
8.92E-03
8.95E-03
8.97E-03
8.97E-03
8.99E-03
9.00E-03
9.01E-03
9.02E-03
9.02E-03
9.03E-03
9.05E-03
9.05E-03
9.08E-03
9.08E-03
9.08E-03
9.10E-03
9.10E-03
9.10E-03
9.11E-03
9.11E-03
9.14E-03
9.14E-03
9.14E-03
9.14E-03
9.15E-03
9.18E-03
9.18E-03
9.19E-03
9.19E-03
9.20E-03
9.21E-03
9.21E-03
9.24E-03
9.25E-03
9.28E-03
9.28E-03
9.31E-03
9.31E-03
9.32E-03
9.33E-03
9.33E-03
9.33E-03
9.39E-03
9.39E-03
9.41E-03
9.43E-03
9.44E-03
9.47E-03
9.49E-03
9.49E-03
9.50E-03
9.51E-03
9.53E-03
9.57E-03
9.57E-03
9.61E-03
9.62E-03
9.62E-03
9.65E-03
9.65E-03
9.67E-03
9.68E-03
9.68E-03
9.70E-03
9.70E-03
9.71E-03
58167
21694
18595
1024
67062
18015
32317
60314
47950
184
6
2231
61642
44478
48047
40247
46049
9275
23171
46099
52463
42884
23113
57686
16463
34542
5633
40353
46197
28463
8634
62501
5161
38886
49417
55213
5716
43661
2861
21890
44584
63427
1093
33678
1638
21402
25886
55974
4724
9634
37268
54634
11462
38632
4539
12191
6879
20830
56992
47710
66002
10770
28100
36808
16186
56702
21232
26412
30945
3473
55516
40551
61553
26708
24623
18533
38923
229
28583
35261
64916
53099
4764
44494
20527
51385
26565
31847
44041
17506
62265
52445
64237
39541
33977
42894
45264
36611
267
36541
24580
35562
25068
18625
41350
66282
14194
43229
36303
36985
54370
6679
17639
23436
9095
30376
9188
40440
8652
11903
16556
18602
41196
42610
11068
54980
21143
59324
13714
61539
27456
52947
64227
56591
13240
45337
4896
37349
63193
35746
19770
17747
8353
13487
17799
53724
61338
6680
36555
54585
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
9318
11060
57835
11047
8728
55687
55627
3059
10149
11237
132625
51030
23287
27433
10629
1959
9381
22974
29880
131601
56649
8816
25821
6688
23637
8631
65980
7006
5515
3570
3606
6404
7264
9423
79877
7125
8467
9667
6210
7108
5651
51104
201243
64783
51693
84129
6570
4324
158056
5702
112970
7941
5930
9689
84643
81627
23034
4303
10081
623
1412
51701
7871
54799
257397
5585
11120
5250
84071
23308
10266
582
339834
56998
8175
1794
3251
139322
5566
266
4331
51585
78996
1945
3452
4287
9860
30832
27020
7543
10732
133957
9140
6483
1060
7697
23380
51524
55285
83443
1506
5913
9727
51129
7013
8933
51773
113444
6871
84064
55559
55661
22835
9588
121355
83759
11273
9447
9058
6520
56992
11074
1398
7182
1196
51741
10687
144193
9252
1185
388364
800
55958
59345
55252
54676
51655
55025
5871
28976
285093
4708
79587
29901
146198
8110
163126
51195
10917
84936
COPS2
WWP2
SLC4A5
ADRM1
ADAM19
TRMU
SMPD4
HCLS1
GPR64
RNF24
ZFP42
TVP23B
AGTPBP1
TOR2A
TAF6L
EGR2
OTOF
TPX2
ALG5
TPRA1
TMPRSS4
DCAF5
MTO1
SPI1
RABGAP1
SKAP1
BRD9
TEC
PPP2CA
IL6R
IL18
SELPLG
TSTA3
NTN1
DCAKD
TNNC2
SMARCA5
SAFB2
RPS15A
TM7SF2
TMPRSS15
ABHD17B
C17orf74
RBM15
TRAPPC2L
ACAD11
SLC18A1
MMP15
MAMDC4
PSMC3
KTI12
PLA2G7
RBBP6
BZW1
KIF2B
TRMT1L
SAMD4A
FOXO4
PDCD7
BDKRB1
CRYBA2
NLK
SLMAP
MBTD1
TAB3
PKN1
BTN2A1
SLC25A3
ARMC2
ICOSLG
RAMP2
BBS1
CCDC36
CTNNBIP1
SF3A2
DOCK2
HPRT1
APOOL
PRKACA
AMELY
MNAT1
PCF11
C7orf49
EFNA4
IFNA21
ATXN3
LRIG2
ZNF354C
NPTN
ZFX
TCFL5
CCDC127
ATG12
ST3GAL2
CENPC
ZNF138
SRGAP2
TMEM138
RBM41
SF3B5
CTRL
RAPSN
RAB11FIP3
ANGPTL4
TERF1
FAM127A
RSF1
SMIM12
TADA2A
HDHD2
HAUS7
DDX27
ZFP30
PRDX6
GTSF1
RBM4B
ATXN2L
AIM2
SLC13A2
SLC3A2
KIF15
TRIM31
CRK
NR2C2
CLK2
WWOX
PNMA2
AMDHD1
RPS6KA5
CLCN6
TMIGD1
CALD1
KLHL9
GNB4
ASXL2
GTPBP2
RASD1
FLJ20712
MAP4K2
ACAD9
CXXC11
NDUFB2
CARS2
SAC3D1
ZFP90
DPF3
EID2
RAPGEFL1
BTNL3
ZFYVE19
--+++++++-+
+++?++
-+++++
+++-++
-+---++++++
++-+-+
-+++++
+++--+
+++-++
--+--+-++++--+-+
---+-+
+++-++
++++-+
----+--+--++-++++-+++
-----+
-----+
++++-+
-+----+--------+
+-++++
--++-++++-+
++---+
-+++++
-+++++
++-+++
----+++++++-+-----?----++-+-+-+
+++?++
--+--+
-+++++
-----+
-+-+++
------+++++
-+++++
++++-+
++-+-+
---+-+++?++
----+-+------+++
--+---+++++
+++++-----++-+++
++++++
+-++-+-+---+--+++++++++-++
+-+--+
---+-+
----+-----+
-+-+++
+--+-+
+--+-+
+-++-+
-+---+
+---++
--++--++--++-+-+
++++++
++-?-+-+--+--+++
-+++++
-+++++
-+----------+?-+-++-+
+-+----+---+---++++++
+++-++
+-+-------++++++
++----+-+----+++
++-+-+
++++-+
++-+++
+-++++
--++-++++++++--+++--+
----+--+-------+
-+-+------+-----+-+++
---+--+----+++++
-+-+++
-+++-+
---++++++++
-+++++
+--+-+
-----+
--+--++-+++
+-++++
--+----+--+
++-+++
+++++--+--++++-+
++-+-+
+-++-+
--+--+
++++++
+----+
++--++
++--++
-+-+++
++++-+
---+-+
---+--+-+---++-++++++
+-++++
-+-+++
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-2.586
2.586
2.585
2.585
2.585
-2.583
2.583
2.583
2.582
2.581
2.581
-2.581
2.581
2.579
-2.579
2.579
2.577
-2.576
-2.576
2.575
2.573
-2.572
-2.572
2.572
-2.571
-2.571
-2.57
2.569
-2.569
2.568
2.568
2.568
2.566
2.566
-2.566
2.565
-2.564
-2.564
-2.563
-2.563
2.563
-2.563
2.562
-2.561
2.56
-2.561
2.561
2.56
2.56
2.559
-2.559
2.559
-2.558
-2.558
2.558
-2.558
2.557
2.557
-2.557
2.557
2.556
-2.556
-2.556
-2.556
2.556
2.556
2.555
-2.555
-2.555
-2.555
2.554
-2.554
2.551
2.55
-2.55
2.549
-2.549
-2.548
2.547
2.547
-2.546
-2.543
2.543
2.543
2.542
-2.541
-2.541
-2.54
2.54
-2.538
-2.538
-2.538
2.538
2.537
-2.536
-2.536
2.535
-2.534
-2.533
2.533
2.532
2.532
2.531
2.529
-2.529
2.529
-2.529
2.528
-2.528
-2.528
-2.528
-2.527
-2.527
-2.528
2.527
-2.526
-2.526
2.525
2.525
2.525
-2.525
2.524
2.524
2.524
-2.524
-2.524
2.523
2.521
-2.521
2.52
2.519
2.519
-2.518
2.518
2.518
2.518
-2.517
2.517
-2.517
2.516
2.515
2.514
2.514
-2.514
-2.514
-2.514
-2.514
2.514
2.514
2.513
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
9.71E-03
9.71E-03
9.72E-03
9.73E-03
9.75E-03
9.79E-03
9.80E-03
9.80E-03
9.82E-03
9.84E-03
9.85E-03
9.86E-03
9.86E-03
9.90E-03
9.90E-03
9.91E-03
9.96E-03
1.00E-02
1.00E-02
1.00E-02
1.01E-02
1.01E-02
1.01E-02
1.01E-02
1.01E-02
1.02E-02
1.02E-02
1.02E-02
1.02E-02
1.02E-02
1.02E-02
1.02E-02
1.03E-02
1.03E-02
1.03E-02
1.03E-02
1.04E-02
1.04E-02
1.04E-02
1.04E-02
1.04E-02
1.04E-02
1.04E-02
1.04E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.05E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.06E-02
1.07E-02
1.07E-02
1.08E-02
1.08E-02
1.08E-02
1.08E-02
1.08E-02
1.08E-02
1.09E-02
1.09E-02
1.09E-02
1.10E-02
1.10E-02
1.10E-02
1.10E-02
1.10E-02
1.11E-02
1.11E-02
1.11E-02
1.11E-02
1.11E-02
1.12E-02
1.12E-02
1.12E-02
1.12E-02
1.12E-02
1.12E-02
1.13E-02
1.13E-02
1.13E-02
1.13E-02
1.14E-02
1.14E-02
1.14E-02
1.14E-02
1.14E-02
1.15E-02
1.15E-02
1.15E-02
1.15E-02
1.15E-02
1.15E-02
1.15E-02
1.15E-02
1.15E-02
1.15E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.16E-02
1.17E-02
1.17E-02
1.17E-02
1.18E-02
1.18E-02
1.18E-02
1.18E-02
1.18E-02
1.18E-02
1.18E-02
1.18E-02
1.18E-02
1.19E-02
1.19E-02
1.19E-02
1.19E-02
1.19E-02
1.19E-02
1.19E-02
1.19E-02
1.20E-02
1.20E-02
1.20E-02
66589
47369
47485
13641
39986
10048
54452
40328
60460
23644
24270
37365
55441
56385
33744
62587
15392
36126
49735
53337
38576
43083
67128
35341
14708
9540
64513
12967
23412
62273
27627
65856
27619
65652
6369
42613
35557
33493
42662
43309
57523
41348
54773
26717
35677
40429
19986
38890
40244
61999
20236
65009
26517
36249
59615
44818
33557
36314
28522
2277
50677
34364
47559
53618
9900
45043
59746
10220
53190
51360
11216
40366
34737
53815
59331
42324
23636
30087
37514
2554
54787
18711
64776
40485
8310
31931
32380
34706
45715
67178
11296
35110
3813
16618
19411
65191
67738
27847
37515
52720
53291
57724
61017
14234
21108
51959
21020
27103
40753
26638
48904
34214
63732
49395
30457
20267
66622
48874
55804
31487
64323
7870
62777
22680
49532
56539
39288
9684
13888
31417
4124
32348
8892
42046
11280
28838
48724
26257
32258
36943
6819
54858
1244
44552
9315
6069
16049
16928
55138
9613
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
90956
83989
5595
585
84246
2936
133746
10048
79033
51726
78991
79073
84941
1656
3182
23510
51398
9949
10826
3045
63939
10135
9669
2208
80262
55521
2972
150000
79676
199990
55086
8405
5229
7846
246744
64849
22898
8970
23381
64689
51422
10773
153830
158584
57343
60412
157697
5705
56951
8846
54938
84811
256364
126432
114926
29086
399827
54677
79412
57609
5793
10827
955
55364
57461
10296
220972
8418
11062
3996
1394
440073
9258
84910
5281
7038
10229
51639
2243
54518
2617
8898
54508
84162
785
51366
284759
57180
53834
9352
9488
5132
7456
51371
641
51673
200895
11284
25979
3212
7283
54995
27074
10912
27089
3096
22955
92703
5447
10342
9690
440400
30061
51203
80381
51728
51703
10712
56896
79143
9377
9203
22858
64951
127294
199870
55199
10572
53905
4640
83856
26233
51341
9095
26610
5029
27189
51676
25999
5188
2550
768
1305
4131
7189
56950
55761
752
23011
23635
ADCK2
FAM172A
MAPK3
BBS4
MED10
GSR
JMY
RANBP9
ERI3
DNAJB11
PCYOX1L
TMEM109
HSH2D
DDX6
HNRNPAB
KCTD2
WDR83OS
AMMECR1
FAXDC2
HBD
FAM217B
NAMPT
EIF5B
FCER2
C16orf70
TRIM36
BRF1
ABCC13
OGFOD2
C1orf86
CXorf57
SPOP
PGGT1B
TUBA1A
STH
SLC13A3
DENND3
HIST1H2BJ
SMG5
GORASP1
PRKAG2
ZBTB6
RNF145
FAAH2
ZNF304
EXOC4
ERICH1
PSMC5
C5orf15
ALKBH1
SARS2
BUD13
EML3
RINL
SMIM19
BABAM1
FLJ46300
CROT
KREMEN2
DIP2B
PTPRG
FAM114A2
ENTPD6
IMPACT
ISY1
MAEA
MARCH8
CMAHP
DUS4L
LLGL1
CRHR1
IQSEC3
MFHAS1
TMEM87B
PIGF
TG
COQ7
SF3B14
FGA
APBB1IP
GARS
MTMR2
EPB41L4A-AS2
KIAA1109
CACNB4
UBR5
SIRPB2
ACTR3B
FGFRL1
TXNL1
PIGB
PDC
WIPF1
POMP
BLM
TPPP3
DHFRL1
PNKP
DHRS7B
HOXB2
TUBG1
OXSM
LAMP3
GADD45G
UQCRQ
HIVEP1
SCMH1
TMEM183A
POR
TFG
UBE3C
RNASEK
SLC40A1
NUSAP1
CD276
POLR3K
ACSL5
FAM189B
DPYSL5
MBOAT7
COX5A
ZMYM3
ICK
MRPS24
MYOM3
FAM76A
FAM86C1
SIVA1
DUOX1
MYO1A
FSD1L
FBXL6
ZBTB7A
TBX19
ELP4
P2RY2
IL17C
ASB2
CLIP3
PET112
GABBR1
CA9
COL13A1
MAP1B
TRAF6
SMYD2
TTC17
FMNL1
RAB21
SSBP2
-----+
++-++++++++
-----+
-----+
++++-+
+--+++---+-----+
-----+
-++-------+
+++?-+
+--+------+
++---+
++++++
+----++-++++-++--++++
+-+-++
-+-++-+---+
-++-++
+++-++
++++++
+++++++-+++
-----+
+--?+-+----+++++
+++++++-+++
++--++
+++--+
----+++++-+
++++-+
--+--+
+-+?-+-+--+
+-+-+---?-+--+-+
+-++-+
-------+?-+
----------+
--+---+---+
-++--+
---+-++++-++++++
+--+-++-+++
--+--+++-++
----------+
+-----+++++
--+-++
++++++-++++
-----++--++
++--++
++--++
++-+++++++--+--+--+++
-----++++-+
++-+++
+-+---+---+
-+---+++-++
+++-++
-++-++
+-+--+-++-+
+-+?-+--+++
-+++-+-+-+-+++++
--++++
+-++++
--++-+-++++
+----+++?++
--++-+
---+--+---+
-------++-++++-+
-+-+++
+-+-----+--+++++
++-+-+
-----+----++++-+
+-++++
+-++-+++-++
---+-++-+-+
++-+-+
++-+++
+++--+
---+----------------+
++++++
+-++++
--------+--+++++
+++-++
++-+++
++-+++
++++++
++-+-+
---+---++-++-+++
++-+++
---+-+
--+?-++++++
+++--+
-+++++
++-+++
++++++
------+---++++-+
+-+?---++--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
-2.513
2.513
2.512
-2.512
-2.51
2.51
-2.509
-2.508
-2.508
-2.507
-2.507
-2.506
2.506
-2.506
-2.506
2.506
2.505
-2.504
2.504
2.503
2.503
2.503
-2.502
-2.501
2.5
2.5
2.499
2.499
2.499
-2.499
-2.499
-2.496
2.496
2.496
2.495
2.495
2.495
-2.495
2.494
2.495
-2.494
-2.494
-2.493
-2.492
-2.492
2.492
2.492
-2.492
-2.492
-2.491
-2.49
-2.489
-2.488
2.488
-2.488
-2.487
2.486
-2.485
2.485
-2.484
2.484
-2.484
-2.484
-2.483
2.483
2.482
2.482
2.481
-2.481
2.48
2.479
2.478
2.477
2.476
-2.476
2.476
-2.475
2.474
2.475
-2.474
-2.474
-2.474
2.474
2.474
2.473
-2.472
2.472
-2.471
2.471
-2.471
2.47
2.47
2.469
2.469
-2.469
2.468
-2.468
2.468
2.467
-2.467
-2.466
-2.466
-2.466
2.465
2.465
-2.464
-2.464
2.463
2.463
-2.463
-2.463
2.463
2.462
-2.461
2.46
-2.46
2.46
2.459
2.459
2.459
-2.459
-2.458
-2.457
-2.457
2.457
2.457
-2.457
-2.456
2.456
2.455
2.454
2.454
2.454
2.454
-2.453
-2.453
2.453
2.452
-2.452
-2.452
2.452
2.45
2.449
2.449
2.448
-2.448
-2.448
2.448
-2.448
-2.447
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.20E-02
1.20E-02
1.20E-02
1.20E-02
1.21E-02
1.21E-02
1.21E-02
1.21E-02
1.22E-02
1.22E-02
1.22E-02
1.22E-02
1.22E-02
1.22E-02
1.22E-02
1.22E-02
1.23E-02
1.23E-02
1.23E-02
1.23E-02
1.23E-02
1.23E-02
1.23E-02
1.24E-02
1.24E-02
1.24E-02
1.24E-02
1.25E-02
1.25E-02
1.25E-02
1.25E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.26E-02
1.27E-02
1.27E-02
1.27E-02
1.27E-02
1.27E-02
1.27E-02
1.27E-02
1.27E-02
1.28E-02
1.28E-02
1.28E-02
1.28E-02
1.28E-02
1.29E-02
1.29E-02
1.29E-02
1.30E-02
1.30E-02
1.30E-02
1.30E-02
1.30E-02
1.30E-02
1.30E-02
1.31E-02
1.31E-02
1.31E-02
1.31E-02
1.32E-02
1.32E-02
1.32E-02
1.33E-02
1.33E-02
1.33E-02
1.33E-02
1.33E-02
1.33E-02
1.33E-02
1.34E-02
1.34E-02
1.34E-02
1.34E-02
1.34E-02
1.34E-02
1.34E-02
1.34E-02
1.35E-02
1.35E-02
1.35E-02
1.35E-02
1.35E-02
1.36E-02
1.36E-02
1.36E-02
1.36E-02
1.36E-02
1.36E-02
1.36E-02
1.36E-02
1.37E-02
1.37E-02
1.37E-02
1.37E-02
1.37E-02
1.37E-02
1.38E-02
1.38E-02
1.38E-02
1.38E-02
1.38E-02
1.38E-02
1.38E-02
1.39E-02
1.39E-02
1.39E-02
1.39E-02
1.39E-02
1.39E-02
1.39E-02
1.39E-02
1.40E-02
1.40E-02
1.40E-02
1.40E-02
1.40E-02
1.40E-02
1.41E-02
1.41E-02
1.41E-02
1.41E-02
1.41E-02
1.41E-02
1.41E-02
1.42E-02
1.42E-02
1.42E-02
1.42E-02
1.42E-02
1.42E-02
1.42E-02
1.43E-02
1.43E-02
1.43E-02
1.44E-02
1.44E-02
1.44E-02
1.44E-02
1.44E-02
1.44E-02
3915
12344
58834
64505
66150
53197
60425
17332
42853
27521
6484
1176
45071
387
55801
57761
38144
23993
10258
65996
26885
46442
29346
63247
11075
8463
61087
45789
42335
54381
27142
53123
43587
32165
39389
46766
26013
20456
55012
63815
65159
40294
52093
36613
36754
51229
9056
48049
10128
56027
21031
8951
44135
3512
19131
6047
43252
15933
40360
65504
18853
46173
56866
16809
4435
5495
9737
38659
39144
40983
57121
1430
64867
66370
7031
54573
21145
24494
4365
10250
12991
35968
25096
56047
8989
24909
57352
45096
19818
42677
64474
15566
48197
41813
14621
14139
17167
19211
39589
54609
35835
51140
67889
4847
52879
16449
64760
41634
2343
3966
25724
27263
46869
8261
3300
61886
66501
46582
36739
52049
40170
39179
51072
14667
22353
43347
30339
29068
34315
21765
59326
50384
62258
64621
56755
66424
15388
36977
22501
21670
26054
46409
41031
32580
42788
54462
63776
50208
55463
58332
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
55249
84649
27439
5255
23415
3619
64423
6416
57110
10401
80760
94235
55669
55662
26277
51108
163786
2078
9114
54210
30833
118
8813
56260
6633
2632
5553
57642
55367
5928
6474
57045
51124
10138
388403
5326
57179
51380
23387
9655
23529
25940
1652
5714
337973
375346
9513
51077
79868
59286
51032
140730
5308
79925
114781
10602
54619
50808
860
85457
10565
30000
4090
9218
146225
8817
83440
819
84975
84864
22937
65005
8935
9463
5678
54762
538
3113
55028
387509
4645
55920
9364
5672
4686
26476
57577
148046
9079
5921
140465
152110
5875
6548
27287
6770
3838
26873
8814
152
7010
51247
23523
203228
10269
7699
8193
90634
64777
4893
8411
284340
9138
2048
427
27236
284656
8566
3434
124944
64978
8829
29929
11226
1429
10589
5836
79365
81533
5354
128977
219844
65095
153364
55779
368
50650
64718
7372
6742
10143
283748
50848
10658
8454
23451
254170
84640
55818
30
YY1AP1
DGAT2
CECR6
PHKA1
KCNH4
INCENP
INF2
MAP2K4
HRASLS
PIAS3
ITIH5
GNG8
MFN1
HIF1AN
TINF2
METTL9
SASS6
ERG
ATP6V0D1
TREM1
NT5C
ADD1
DPM1
C8orf44
SNRPD2
GBE1
PRG2
COL20A1
PIDD
RBBP4
SHOX2
TWSG1
IER3IP1
YAF2
YPEL2
PLAGL2
KIAA1191
CSAD
SIK3
SOCS5
CLCF1
FAM98A
DDT
PSMD8
KRTAP19-6
TMEM110
FXR2
FCF1
ALG13
UBL5
CELA2B
RIMS4
PITX2
SPEF2
BTBD9
CDC42EP3
CCNJ
AK3
RUNX2
KIAA1737
ARFGEF1
TNPO2
SMAD5
VAPA
CMTM2
FGF18
ADPGK
CAMLG
MFSD5
MINA
SCAP
MRPL9
SKAP2
PICK1
PSG9
GRAMD1C
ATP7A
HLA-DPA1
C17orf80
GPR153
MYO5B
RCC2
RAB28
PSG4
NCBP1
OR10J1
KIAA1407
CIRBP-AS1
LDB2
RASA1
MYL6B
NEK10
RABGGTA
SLC9A1
VENTX
STAR
KPNA2
OPLAH
CDKL1
ADRA2C
TEK
PAIP2
CABIN1
C9orf72
ZMPSTE24
ZNF140
DPF1
N4BP2L1
RMND5B
NRAS
EEA1
CXCL17
ARHGEF1
EPHB2
ASAH1
ARFIP1
EPHA10
PDXK
IFIT1
C17orf49
MRPL38
NRP1
ALG6
GALNT6
CRYZ
DRAP1
PYGL
BHLHE41
ITFG1
PLP1
C22orf39
HYLS1
KRI1
MBLAC2
WDR52
ABCC6
ARHGEF3
UNKL
UMPS
SSBP1
CLEC3A
PLA2G4D
F11R
CELF1
CUL1
SF3B1
FBXO33
USP38
KDM3A
ACAA1
++-+++-++++
+++++++++++
+--+-+
+++--+
++++++
+-+--++-++++-+++
++--++
---+------++-+++
++-+++
-+++-+
--+--+-++++
-++--+
+-+--+
-----+
++-+++
--+?++-------+-+
+-+--+
++-+++
-++--+
-----+
+-+---+++++
++++++
+-++--+-----++++
+--+++
+--+-+-++-+
++++-+
--+--++-+++
--+-----+-+
-+--++
+-++-+
-+-+++
++-+++
---++--+++-++++-+++++
+++--+
+++-++
-+-?-++-+++
+-+-++
---+-+------+----+-++
+-+------++
+-++-+
+-+?-++++-+
++-+-+
+-+--+
---++++---+
--+-+-----+
---+-+
++++++
-+++-+
+++++--+--+-+---+-+++
---++++++++
+--+++
-----+
--++-+-++++
--++++++-++
+----++++++
--+--+-----+-+++
++-+-+
+-++++
++-?++
++++++
++++++
+-++-+
+-++-+
+++++++-+++
-+-----++---+--+-++++-++++
+----+++--+
--++------+
--++++
+--+-++-+++
-+---+
++++-+
++++++
+-++-+
++-+++
++--++
++++++
-+-+++
--+--+
-++?-+
--++-++++-+
+--?-++++++-++-+
-+---+-+++-+++-+
--+-----+--+--+--+--+--++-++?++
+----+
-++--+
+------++--+++++
-+++++
+-++-+
+-++-+
-----+-+--+
+-+--+-+--+-+---++--+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
2.447
2.447
2.447
2.447
2.447
2.446
2.446
-2.446
2.446
2.445
2.445
-2.444
-2.443
2.443
2.442
2.442
-2.441
2.44
2.439
2.439
-2.438
2.438
-2.437
-2.437
-2.437
2.436
2.436
2.436
-2.436
-2.435
2.435
2.435
-2.435
-2.434
2.434
2.434
-2.434
2.433
2.433
-2.432
2.432
-2.431
-2.431
2.429
2.429
2.429
2.429
-2.429
-2.428
2.427
2.427
2.427
2.427
-2.425
2.425
2.425
-2.425
-2.424
-2.424
-2.423
-2.423
-2.422
2.421
-2.42
2.42
2.419
2.418
-2.418
2.418
-2.418
-2.418
-2.418
2.416
2.416
2.416
-2.416
-2.416
2.415
-2.415
2.415
2.415
-2.415
-2.414
2.414
-2.414
2.414
-2.413
2.412
-2.412
-2.411
2.411
2.41
2.409
2.408
2.408
2.408
2.408
2.408
2.407
2.407
-2.407
-2.407
-2.406
2.405
2.405
-2.405
2.404
-2.403
-2.402
2.402
-2.402
2.401
-2.401
2.401
2.401
2.401
2.401
2.401
2.4
2.4
-2.399
2.398
-2.397
2.396
-2.396
2.396
2.396
-2.396
2.395
2.394
-2.394
-2.394
-2.394
-2.393
-2.392
2.392
2.392
2.391
-2.391
-2.39
2.386
2.386
2.384
2.384
-2.383
-2.382
-2.381
-2.381
-2.38
2.38
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.44E-02
1.44E-02
1.44E-02
1.44E-02
1.44E-02
1.44E-02
1.44E-02
1.44E-02
1.45E-02
1.45E-02
1.45E-02
1.45E-02
1.46E-02
1.46E-02
1.46E-02
1.46E-02
1.46E-02
1.47E-02
1.47E-02
1.48E-02
1.48E-02
1.48E-02
1.48E-02
1.48E-02
1.48E-02
1.48E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.49E-02
1.50E-02
1.50E-02
1.50E-02
1.50E-02
1.51E-02
1.51E-02
1.51E-02
1.51E-02
1.51E-02
1.52E-02
1.52E-02
1.52E-02
1.52E-02
1.52E-02
1.52E-02
1.52E-02
1.53E-02
1.53E-02
1.53E-02
1.53E-02
1.53E-02
1.54E-02
1.54E-02
1.54E-02
1.54E-02
1.55E-02
1.55E-02
1.55E-02
1.56E-02
1.56E-02
1.56E-02
1.56E-02
1.56E-02
1.56E-02
1.56E-02
1.57E-02
1.57E-02
1.57E-02
1.57E-02
1.57E-02
1.57E-02
1.58E-02
1.58E-02
1.58E-02
1.58E-02
1.58E-02
1.58E-02
1.58E-02
1.58E-02
1.58E-02
1.59E-02
1.59E-02
1.59E-02
1.59E-02
1.60E-02
1.60E-02
1.60E-02
1.60E-02
1.60E-02
1.60E-02
1.61E-02
1.61E-02
1.61E-02
1.61E-02
1.61E-02
1.61E-02
1.62E-02
1.62E-02
1.62E-02
1.62E-02
1.63E-02
1.63E-02
1.63E-02
1.63E-02
1.63E-02
1.63E-02
1.63E-02
1.64E-02
1.64E-02
1.64E-02
1.64E-02
1.64E-02
1.64E-02
1.64E-02
1.65E-02
1.65E-02
1.66E-02
1.66E-02
1.66E-02
1.66E-02
1.66E-02
1.66E-02
1.67E-02
1.67E-02
1.67E-02
1.67E-02
1.67E-02
1.68E-02
1.68E-02
1.68E-02
1.68E-02
1.68E-02
1.68E-02
1.70E-02
1.70E-02
1.71E-02
1.71E-02
1.72E-02
1.72E-02
1.73E-02
1.73E-02
1.73E-02
1.73E-02
8906
42566
56915
3903
17313
63601
22153
60492
4723
15830
17636
37015
33936
57298
67097
42595
44865
7408
16395
26631
34835
45965
15721
596
58905
16574
15567
18835
2133
44807
48782
64073
20481
54614
58456
36467
65406
22452
10818
46738
7158
58200
4742
6367
54331
12843
18911
46020
37296
49230
48191
24719
11113
21268
37034
43537
10107
48789
52097
39146
53925
46850
4697
787
51200
58621
61414
34168
39634
31192
12373
33415
62079
26821
29019
31585
46866
36189
56522
60076
41845
40137
7231
42216
61576
46587
62085
18677
57617
16738
10375
16531
57645
36030
7491
23532
50883
57714
24505
48939
15396
34010
9192
51962
42049
20079
3717
53018
3670
3899
18334
17667
51454
41072
19900
39690
16147
33342
64430
46337
9751
31992
59319
2294
24799
53252
53440
24602
37698
49629
2675
44759
27631
20198
52158
1559
42688
49512
847
16315
57934
59552
32193
64992
28383
7294
37369
29936
16755
56201
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
5860
55509
283899
134637
80221
9197
7059
339366
55850
142940
79654
122769
4771
283401
9780
6443
84221
11231
55786
5589
10557
143686
91694
728
92667
83452
131096
407738
64834
1427
1798
991
5954
10238
1893
7873
1602
1113
3916
5467
5160
51283
4714
5686
3875
79943
10942
64427
83862
10004
3782
84451
9754
10123
221895
26575
81502
8560
23526
51253
55210
80264
23219
57157
51170
151963
5724
51571
10454
51691
11104
55656
57532
221491
124995
51633
9086
3981
9871
1418
25900
8364
9687
55974
147172
8533
55173
55330
479
163590
23625
6093
4111
5360
126626
2299
78995
54344
5371
55814
784
114881
2358
64860
51014
1135
4121
533
8869
28970
1211
51531
51574
6718
7752
26073
389337
6339
63891
7350
389125
25988
282973
100
54890
4798
474382
140836
246184
5536
376940
374395
60
79368
5516
5361
57380
9450
10111
6790
3068
6744
51699
27181
115330
6256
23338
84340
9586
10618
QDPR
BATF3
INO80E
ADAT2
ACSF2
SLC33A1
THBS3
ADAMTSL5
USE1
TRUB1
HECTD3
LRR1
NF2
FLJ33996
PIEZO1
SGCB
SPATC1L
SEC63
ZNF415
PRKCSH
RPP38
SESN3
LONRF1
C5AR1
MGME1
RAB33B
KCNH8
FAM19A1
ELOVL1
CRYGS
DPAGT1
CDC20
RCN1
DCAF7
ECM1
MANF
DACH1
CHGA
LAMP1
PPARD
PDHA1
BFAR
NDUFB8
PSMA5
KRT18
ZNF696
PRSS21
TTC31
TMEM120A
NAALADL1
KCNN3
MLK4
STARD8
ARL4C
JAZF1
RGS17
HM13
DEGS1
HMHA1
MRPL37
ATAD3A
ZNF430
FBXO28
PHTF2
HSD17B11
MB21D2
PTAFR
FAM49B
TAB1
NAA38
KATNA1
INTS8
NUFIP2
C6orf1
MRPL10
OTUD6B
EIF1AY
LIG4
SEC24D
CRYGA
IFFO1
HIST1H4C
GREB1
SLC50A1
LRRC37BP1
COPS3
MRPS10
BLOC1S4
ATP12A
TOR1AIP2
FAM89B
ROCK1
MAGEA12
PLTP
GABPB2
FOXI1
C17orf53
DPM3
PML
BDP1
CACNB3
OSBPL7
FPR2
ARMCX5
TMED7
CHRNA2
MAN1A1
ATP6V0B
ST3GAL5
C11orf54
CLTA
C9orf156
LARP7
AKR1D1
ZNF200
POLDIP2
ARHGEF37
SCNN1D
RNF123
UCP1
MUSTN1
HINFP
JAKMIP3
ADA
ALKBH5
NFRKB
H2AFB1
BANF2
CDC26
PPP5C
ZC3H6
TMEM179B
ACTB
FCRL2
PPP2CB
PLXNA1
MRS2
LY86
RAD50
AURKA
HDGF
SSFA2
VPS29
SIGLEC8
GPR146
RXRA
PHF15
GFM2
CREB5
TGOLN2
-----+
+--+++
+++-++
-++--+-+--+
+-+--+-+--+
+-+-++
---+--++--++-+++
--+-+--+-++
-++-++
++--++
++++-+
-----+
--+-+--++------+
--++-++++++-++++
++++-+
++++++
+-++-+
--+?-++-+++
+++--+
+---------+
-----+
---+--+-+++
++++++
-----+
+-++-+
++++++
+--+-+
--+----+----+-------+
---+-----++
---?-+
-----+
++-+++
++++-+
+-++++
+++--+
++-+++
+-++-+
++++-+
+++++++++++
-+++++
++++-+
-----+
---+-+
---+-+
--+----++-------++-++
++-++-+++-+
+-++++
---?-+
--+--+--+++
--+--++++++-++-+
+-++-+
---?----+-++++++-+--+
+++++++---+
-+-++++--++
-+++++
++++-+
---++---+------++++-+
+-++-+
++-+++-+?-+++-++
++-+++
------++--+
-+-+++
-+++++
-+-+++
++---++--++
++-+-+
+-+-++
--+--+-++-+
+++-++
+-++++
+++--+
++-+-+
--++--+++-+
---+-+
--+--++--++
--+--+----++--++
---+-+
++-+++----+---++
---+-+
++--++
-+-+-+---------+-++++
+++-++
---+-+-++++
+-+---+++-+
++++++
---++--+--+----+
--+----++-+
---?----+-++-+++-++-+
+-+++++++-+
++-++++++-+
++---+
--+--+-+?-+
+--?++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
-2.379
2.378
2.378
-2.377
2.377
-2.377
2.377
2.376
-2.375
-2.375
2.375
-2.374
2.374
2.374
2.373
2.373
-2.373
-2.372
-2.371
-2.371
-2.371
2.37
2.37
2.369
2.369
2.368
-2.367
2.367
2.367
-2.367
-2.366
-2.365
-2.365
2.365
2.364
-2.363
2.363
2.363
2.363
-2.362
-2.361
-2.36
-2.359
-2.359
-2.359
-2.359
-2.358
2.358
2.358
2.358
2.357
2.357
2.357
2.356
2.356
2.356
2.356
2.355
-2.355
-2.354
-2.354
-2.354
-2.353
-2.353
2.352
2.352
2.351
2.351
-2.351
-2.351
2.35
-2.349
2.349
2.348
2.347
-2.347
-2.347
2.346
2.346
2.346
2.346
-2.344
2.344
2.343
2.343
-2.343
-2.342
-2.342
2.341
2.341
2.341
-2.341
2.34
2.34
-2.34
2.339
2.339
2.339
2.339
-2.338
2.337
2.338
2.337
-2.336
2.336
2.336
2.335
2.334
2.333
-2.332
2.331
-2.33
-2.331
2.33
-2.329
-2.329
2.329
-2.327
2.327
-2.327
2.326
-2.326
2.325
-2.324
-2.324
-2.323
2.323
2.323
-2.323
2.322
-2.322
2.318
2.317
-2.317
-2.316
-2.315
-2.315
-2.314
-2.314
-2.313
2.313
2.313
2.312
2.311
2.311
2.31
-2.309
-2.309
2.309
2.308
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.74E-02
1.74E-02
1.74E-02
1.74E-02
1.75E-02
1.75E-02
1.75E-02
1.75E-02
1.75E-02
1.76E-02
1.76E-02
1.76E-02
1.76E-02
1.76E-02
1.76E-02
1.77E-02
1.77E-02
1.77E-02
1.77E-02
1.77E-02
1.77E-02
1.78E-02
1.78E-02
1.78E-02
1.79E-02
1.79E-02
1.79E-02
1.79E-02
1.80E-02
1.80E-02
1.80E-02
1.80E-02
1.80E-02
1.81E-02
1.81E-02
1.81E-02
1.81E-02
1.81E-02
1.82E-02
1.82E-02
1.82E-02
1.83E-02
1.83E-02
1.83E-02
1.83E-02
1.83E-02
1.84E-02
1.84E-02
1.84E-02
1.84E-02
1.84E-02
1.84E-02
1.84E-02
1.85E-02
1.85E-02
1.85E-02
1.85E-02
1.85E-02
1.85E-02
1.86E-02
1.86E-02
1.86E-02
1.86E-02
1.86E-02
1.87E-02
1.87E-02
1.87E-02
1.87E-02
1.87E-02
1.88E-02
1.88E-02
1.88E-02
1.88E-02
1.89E-02
1.89E-02
1.89E-02
1.89E-02
1.90E-02
1.90E-02
1.90E-02
1.90E-02
1.91E-02
1.91E-02
1.91E-02
1.91E-02
1.92E-02
1.92E-02
1.92E-02
1.92E-02
1.92E-02
1.92E-02
1.92E-02
1.93E-02
1.93E-02
1.93E-02
1.94E-02
1.94E-02
1.94E-02
1.94E-02
1.94E-02
1.94E-02
1.94E-02
1.95E-02
1.95E-02
1.95E-02
1.95E-02
1.96E-02
1.96E-02
1.97E-02
1.97E-02
1.98E-02
1.98E-02
1.98E-02
1.98E-02
1.98E-02
1.99E-02
1.99E-02
2.00E-02
2.00E-02
2.00E-02
2.00E-02
2.00E-02
2.01E-02
2.01E-02
2.01E-02
2.02E-02
2.02E-02
2.02E-02
2.02E-02
2.02E-02
2.02E-02
2.04E-02
2.05E-02
2.05E-02
2.06E-02
2.06E-02
2.06E-02
2.06E-02
2.07E-02
2.07E-02
2.07E-02
2.07E-02
2.08E-02
2.08E-02
2.09E-02
2.09E-02
2.09E-02
2.09E-02
2.09E-02
2.10E-02
9640
34541
14586
66193
29069
58426
66488
10261
26692
11507
41217
51710
47826
64532
16815
42843
60754
43656
65910
30589
51131
24774
25672
40978
52965
31833
61327
64519
24657
25590
2400
33691
68339
669
36544
4596
64801
14422
3013
21732
14596
7657
34597
60199
35838
37808
13722
980
33840
14315
7285
31385
48587
51270
16028
58799
26770
25446
16533
26162
55247
66904
43174
30684
40398
232
24426
63631
25676
29081
57971
48843
49066
23092
46129
52250
25791
54875
35895
38238
48546
15201
53046
13512
29708
40095
2794
47395
10032
53500
18525
57098
14908
58196
51039
55096
53971
2594
31060
63031
23418
56101
12398
5686
736
42140
11926
31237
40749
28656
4547
38337
2161
7393
62052
15339
42425
64243
49995
57760
64526
33353
24785
884
44184
3772
9269
22315
15913
21470
39936
35201
7257
823
21462
55720
45011
13879
38627
49257
7906
49895
27581
12676
21938
7796
330
30343
53370
771
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
55287
9755
53831
83734
1386
25909
10644
9040
5286
285605
9966
80007
55973
219453
9682
57017
23125
2237
1389
388561
162
284273
23475
80145
9094
5939
23012
2069
4126
1362
54552
387119
285362
56267
84326
6990
56475
129804
7544
3455
23187
5980
84836
326625
22828
50636
670
9903
10267
4012
55565
55119
378
23677
53981
11275
64866
10193
4660
9541
56660
375061
100132888
64699
6708
64324
63905
2737
51526
90379
60313
3229
348235
3987
51244
7008
54545
4711
51231
84929
6242
3301
56675
9880
347862
63922
5296
8482
63901
10608
10243
51637
54749
54521
402682
2859
291
79624
388591
51474
9349
81932
25822
4731
51742
54853
29966
754
439916
114815
6812
5373
54892
10721
51780
286016
55009
4752
7730
85027
3678
7587
1468
219927
55229
1493
60467
7580
6713
219654
9829
26061
6629
6103
55660
79639
1984
60684
4597
1009
3364
29028
22982
388931
51010
29970
55527
51284
1149
2491
TMEM40
TBKBP1
GPR84
ATG10
ATF2
AHCTF1
IGF2BP2
UBE2M
PIK3C2A
DTWD2
TNFSF15
C10orf88
BCAP29
OR8K5
KDM4A
COQ9
CAMTA2
FEN1
CREBL2
ZNF761
AP1B1
ZADH2
QPRT
THOC7
UNC119
RBMS2
STK38L
EREG
MANBA
CPD
GNL3L
CEP85L
SUMF1
CCBL2
C16orf13
DYNLT3
RPRM
FBLN7
ZFY
IFNAR2
PHLDB1
REV3L
ABHD14B
MMAB
SCAF8
ANO7
BPHL
KLHL21
RAMP1
LNPEP
ZNF821
PRPF38B
ARF4
SH3BP4
CPSF2
KLHL2
CDCP1
RNF41
PPP1R12B
CIR1
KCNK12
FAM89A
PGK1
TMPRSS3
SPTA1
NSD1
MANBAL
GLI3
OSER1
DCAF15
GPBP1L1
HOXC13
SKA2
LIMS1
CCDC174
TEF
MTMR12
NDUFB5
VRK3
FIBCD1
RTKN
DNAJA1
NRIP3
ZBTB39
PDDC1
CHTF18
PIK3R2
SEMA7A
FAM111A
MXD4
GPHN
C14orf166
EPDR1
WDR44
UFSP1
GPR35
SLC25A4
C6orf211
RNF207
LIMA1
RPL23
HDHD3
DNAJB5
NDUFV3
ARID4B
WDR55
STRN3
PTTG1IP
LINC00615
SORCS1
STXBP1
PMM2
NCAPG2
POLQ
KDM3B
LOC286016
C19orf24
NEK3
ZNF177
SMIM3
ITGA5
ZNF37A
SLC25A10
MRPL21
PANK4
CTLA4
BPESC1
ZNF32
SQLE
ZCCHC24
DNAJC6
HACL1
SNRPB2
RPGR
PRPF40A
TMEM53
EIF5A
TRAPPC11
MVD
CDH11
HUS1
ATAD2
DIP2C
MFSD2B
EXOSC3
SCHIP1
FEM1A
TLR7
CIDEA
CENPI
++-?++++?++
+++-++
++++++
--++-+-+--+++++++-+++
---?---+--+++-++
--+--+++++++-+++
-+-+++
---+-+
++--++
-----+
+--++-----++-+-+
++-+++
++++-+
---++++++-+
--++-+
--+--+--?++
+-++-+
+-+-++
-+--+--++-+-++-+
+-------+-+-+--++-+-+
+-------++-++--++-+++
+--+------+
+---------+-++++
-----+++--+
++++++
+++-++
++--++
--+----++----+-+
-+-+-+-+?-+
++++++
-+++-+
-++---++--++-+++
---+-+
+++?++
++++++
+-+?-++++-+
--++-+
---+++
+++?+++++++
+++--+
-+++++
+++?++
--+++----+++-+++
+--+++
--++-+
-++?++
++++++
+++-++
--++-++-++------+---+
-----++-++++-+++
+++++++--++
+------++-+-+--+
+-+---+---+-+?-+
-----+
+-++-+
++-+++
---+---+++------++-++
---+-+
+-+--++++-+
+-+-++++-++
++-+++
+-++++
+---+-++-+-+-?----?-+-+?-+
+++++-+---+
+-++-+
--++-++-+++
++++-+
++---+--+++
+-+-++
-----+---++
++-+++
---+------+
++++++
-+--+---++---+-+
--+--+-+--++++-+
-+++++
-----+
-+-?-+
++++++
+-++++
+-+-+-----++-++--+++--+---+-++--++++
-+++++
-++-+-
6376
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
2.308
2.308
2.308
2.307
-2.307
-2.306
2.305
2.305
-2.305
-2.305
2.303
-2.303
2.303
2.302
2.301
-2.301
2.301
-2.301
-2.3
-2.299
2.299
2.299
2.299
-2.299
2.298
2.298
-2.298
2.298
2.297
2.297
-2.297
-2.297
2.296
-2.296
-2.296
-2.295
2.295
-2.295
-2.295
-2.292
2.291
-2.29
-2.29
-2.29
-2.289
2.289
-2.288
2.288
2.287
2.287
2.286
-2.286
-2.286
-2.286
-2.285
2.285
2.284
2.283
-2.283
-2.282
2.282
-2.282
2.282
2.281
-2.281
2.28
2.28
2.279
2.279
2.278
2.277
2.277
2.276
-2.276
-2.276
2.276
2.275
-2.275
2.275
2.275
2.275
-2.274
2.274
-2.274
-2.274
-2.273
2.272
2.272
2.271
2.271
-2.269
-2.269
2.269
-2.268
-2.267
2.267
-2.267
2.267
2.266
-2.264
-2.263
-2.263
2.262
-2.262
-2.261
2.261
-2.26
2.26
2.26
2.258
-2.258
-2.257
-2.257
-2.257
2.257
2.257
-2.256
2.256
-2.256
2.256
2.256
-2.256
2.255
2.255
-2.254
2.254
2.253
-2.253
-2.253
2.252
-2.252
-2.252
-2.251
-2.251
-2.251
2.251
2.251
-2.251
2.25
2.25
2.25
-2.249
-2.249
2.249
-2.249
-2.248
2.247
2.247
2.247
-2.246
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.10E-02
2.10E-02
2.10E-02
2.11E-02
2.11E-02
2.11E-02
2.12E-02
2.12E-02
2.12E-02
2.12E-02
2.13E-02
2.13E-02
2.13E-02
2.14E-02
2.14E-02
2.14E-02
2.14E-02
2.14E-02
2.15E-02
2.15E-02
2.15E-02
2.15E-02
2.15E-02
2.15E-02
2.15E-02
2.16E-02
2.16E-02
2.16E-02
2.16E-02
2.16E-02
2.16E-02
2.16E-02
2.17E-02
2.17E-02
2.17E-02
2.17E-02
2.17E-02
2.18E-02
2.18E-02
2.19E-02
2.20E-02
2.20E-02
2.20E-02
2.20E-02
2.21E-02
2.21E-02
2.21E-02
2.22E-02
2.22E-02
2.22E-02
2.22E-02
2.22E-02
2.22E-02
2.23E-02
2.23E-02
2.23E-02
2.24E-02
2.24E-02
2.25E-02
2.25E-02
2.25E-02
2.25E-02
2.25E-02
2.26E-02
2.26E-02
2.26E-02
2.26E-02
2.27E-02
2.27E-02
2.28E-02
2.28E-02
2.28E-02
2.28E-02
2.29E-02
2.29E-02
2.29E-02
2.29E-02
2.29E-02
2.29E-02
2.29E-02
2.29E-02
2.29E-02
2.30E-02
2.30E-02
2.30E-02
2.30E-02
2.31E-02
2.31E-02
2.32E-02
2.32E-02
2.32E-02
2.32E-02
2.33E-02
2.34E-02
2.34E-02
2.34E-02
2.34E-02
2.34E-02
2.34E-02
2.36E-02
2.36E-02
2.36E-02
2.37E-02
2.37E-02
2.37E-02
2.38E-02
2.38E-02
2.38E-02
2.39E-02
2.39E-02
2.39E-02
2.40E-02
2.40E-02
2.40E-02
2.40E-02
2.40E-02
2.40E-02
2.40E-02
2.41E-02
2.41E-02
2.41E-02
2.41E-02
2.41E-02
2.41E-02
2.42E-02
2.42E-02
2.43E-02
2.43E-02
2.43E-02
2.43E-02
2.43E-02
2.43E-02
2.44E-02
2.44E-02
2.44E-02
2.44E-02
2.44E-02
2.44E-02
2.44E-02
2.45E-02
2.45E-02
2.45E-02
2.45E-02
2.45E-02
2.45E-02
2.46E-02
2.46E-02
2.46E-02
2.46E-02
2.47E-02
6867
12896
29762
53160
10065
36345
16444
10553
11411
48052
4644
44335
43061
61612
21563
45937
4363
37764
17531
23676
30449
51729
13116
25950
39375
3669
20131
408
16011
58079
46939
3632
7945
58556
4760
26196
20288
18532
61681
9595
2406
62238
13800
60029
39606
67552
5390
25857
3197
9526
10765
42881
66302
10696
27497
18987
57051
53376
4009
7854
23465
65908
47468
17241
3279
58797
54028
7225
12875
25302
12656
37738
4692
42706
23108
58721
49128
62303
9564
44578
3150
59460
46069
12614
23627
20196
4493
28723
2790
59249
59841
39067
47697
52074
62182
27656
37344
4888
12126
24269
54661
60022
65498
9561
36729
32076
18511
59804
48036
56813
19196
37917
55831
29189
6410
40541
19780
19881
27700
17275
62981
38342
6644
16915
64138
45372
40650
59404
66445
54641
56802
38607
33028
50247
18350
48976
29855
21806
21875
27365
64819
66344
7451
59816
12800
27885
64928
63804
53606
1876
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
51326
51564
11017
55194
261726
442454
8776
7862
56127
25936
4297
1690
3725
222256
23039
444
7760
8500
6674
285848
84924
400566
6397
150094
55190
6884
1230
64926
7799
2821
132720
2534
145482
5518
7549
90
30827
384
49854
84310
137075
22902
6451
22882
389058
53349
58155
1444
947
23269
23586
167227
10189
29907
51667
26057
220082
54956
905
63895
54929
23291
553115
221833
1601
5709
196740
2055
85440
55717
10605
54581
28972
9616
60312
55006
1785
5093
35
148022
246734
57050
56928
23065
5982
1393
79187
29800
55039
10621
10477
84722
112849
3232
256586
4130
55512
22936
672
22827
7067
27098
100129828
25798
29855
84839
84069
84174
9425
349136
90407
4236
825
155054
64897
56990
2766
9522
26531
113130
1051
26088
4343
64854
79019
1728
136647
91612
144165
9474
644150
2630
10484
23020
129790
10087
137695
4311
23228
8642
169355
83746
65985
84281
51297
64386
286410
55148
387700
22926
ARL17A
HDAC7
SNRNP27
EVA1B
TIPRL
LOC442454
MTMR1
BRPF1
PCDHB10
NSL1
KMT2A
COCH
JUN
CDHR3
XPO7
ASPH
ZNF213
PPFIA1
SPAG1
PNPLA1
ZNF566
C17orf97
SEC14L1
SIK1
NUDT11
TAF13
CCR1
RASAL3
PRDM2
GPI
C4orf32
FYN
PTGR2
PPP2R1A
ZNF2
ACVR1
CXXC1
ARG2
ZBTB21
C7orf50
CLDN23
RUFY3
SH3BGRL
ZHX2
SP5
ZFYVE1
PTBP2
CSHL1
CD34
MGA
DDX58
DCP2
ALYREF
SNX15
NUB1
ANKRD17
SPERT
PARP16
CCNT2
PIEZO2
TMEM161A
FBXW11
PEF1
SP8
DAB2
PSMD3
VSTM4
CLN8
DOCK7
WDR11
PAIP1
SCAND2P
SPCS1
RNF7
AFAP1
TRMT61B
DNM2
PCBP1
ACADS
TICAM1
NPCDR1
UTP3
SPPL2B
EMC1
RFC2
CRHBP
FSD1
ZDHHC1
TRMT12
POLR3F
UBE2E3
PSRC1
L3HYPDH
HOXD3
LYSMD2
MAP1A
SMPD3
ELL2
BRCA1
PUF60
THRA
CLUL1
PDZD11
BRI3
UBN1
RAX2
PLEKHN1
SLA2
CDYL
WDR86
TMEM41A
MFAP1
CAPN3
ZNF425
C12orf43
CDC42SE2
GMPR
SCAMP1
OR11A1
CDCA5
CEBPB
GGA1
MOV10
USP46
CENPM
NQO1
MPLKIP
CHURC1
PRICKLE1
ATG5
WIPF3
GBAP1
SEC23A
SNRNP200
C7orf13
COL4A3BP
TMEM68
MME
PLCL2
DCHS1
IDO2
L3MBTL2
AACS
C2orf88
BPIFA1
MMP25
ATP11C
UBR7
SLC16A12
ATF6
-+--+-------+--++++-+
-++++-----+-+-------+
+++-++
-+++++
++--+-----+--+++
---?-++-+++++-+++-+-+
--++++
+-++++
+-+--+
-+--+--+--+-+?+--------+--+---+-+-++
++--++
+++++++-+++
+++--+
++-+++
+--++-----+
-----+
+-----+---+
+++++---+-++-+++
++++-+
+----+-+++------+++++
++++-+
--+--++--++
------+--++
++++-+-+-----+-++++++
++-+++
--+?--+++++
---+-+
--+--++++++
-----+
+---++
++++++
++-+++
+++++---+-+
++-+-+
--+?-+
+-+--+-++-+
-+++++
--+----++-+
--++++
++--++
--++-+++--+
+-----+++++
++-+-+
+--++--++----+-+
-----+
-+++-+
+++?++
-+--++
+-+-++
--++-+
+-+--+++++--++-+
--+--+++?++
+-++-++--++
++-?-+
--+--+-+-------+
------++-++
+++-++
-+++-+
+++--+
++++++
++--++
++--++
--++-+---------+
--++--+-+-+
--+----+--+
+-+--++-+++-++++
++++++
-----+
+-++++
+++--+
++--++
++++-+
-----+-++-+
--+--+--+--+---+
--++--+++++
++--++
+---------+
-+----++--+
-+-+-++++-+--+---+--+-+++----++
----++
++--++++--+
++++++
+-+--+-+--+++--+
+-++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-2.245
-2.245
-2.245
2.245
2.245
-2.244
-2.244
-2.243
2.243
2.243
-2.243
-2.243
2.243
-2.243
2.242
2.242
2.241
2.241
2.241
2.241
-2.24
-2.24
-2.24
-2.24
-2.24
-2.239
2.239
2.238
2.238
2.238
2.238
2.237
-2.237
-2.237
-2.237
-2.236
-2.236
2.236
-2.234
2.234
2.234
-2.234
-2.233
-2.232
2.232
2.231
-2.231
2.23
-2.23
2.23
2.229
-2.229
-2.228
2.227
2.227
-2.227
2.226
-2.225
-2.225
2.224
-2.224
2.224
2.224
2.224
2.222
-2.222
2.222
-2.222
-2.222
2.221
2.221
-2.221
-2.221
2.219
2.219
-2.218
2.218
-2.216
2.216
2.215
-2.215
-2.214
-2.214
-2.213
2.213
2.213
2.213
2.212
-2.211
-2.21
2.209
2.209
-2.208
2.208
-2.208
2.207
2.207
-2.207
-2.206
-2.206
-2.206
2.206
2.206
2.205
2.205
2.205
2.203
2.203
-2.203
-2.203
-2.202
-2.202
2.202
-2.201
-2.201
-2.201
2.2
2.2
2.2
-2.198
2.198
2.197
2.197
2.197
-2.197
2.196
-2.196
-2.196
-2.196
-2.196
2.195
2.194
-2.193
-2.193
-2.193
2.193
-2.192
2.192
-2.191
-2.19
2.19
-2.19
-2.189
-2.189
2.188
2.188
-2.188
-2.187
2.187
2.187
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2.48E-02
2.48E-02
2.48E-02
2.48E-02
2.48E-02
2.48E-02
2.49E-02
2.49E-02
2.49E-02
2.49E-02
2.49E-02
2.49E-02
2.49E-02
2.49E-02
2.50E-02
2.50E-02
2.50E-02
2.50E-02
2.50E-02
2.50E-02
2.51E-02
2.51E-02
2.51E-02
2.51E-02
2.51E-02
2.51E-02
2.52E-02
2.52E-02
2.52E-02
2.52E-02
2.53E-02
2.53E-02
2.53E-02
2.53E-02
2.53E-02
2.53E-02
2.53E-02
2.54E-02
2.55E-02
2.55E-02
2.55E-02
2.55E-02
2.55E-02
2.56E-02
2.56E-02
2.57E-02
2.57E-02
2.57E-02
2.58E-02
2.58E-02
2.58E-02
2.58E-02
2.59E-02
2.59E-02
2.60E-02
2.60E-02
2.60E-02
2.61E-02
2.61E-02
2.61E-02
2.61E-02
2.61E-02
2.62E-02
2.62E-02
2.63E-02
2.63E-02
2.63E-02
2.63E-02
2.63E-02
2.63E-02
2.63E-02
2.63E-02
2.64E-02
2.65E-02
2.65E-02
2.66E-02
2.66E-02
2.67E-02
2.67E-02
2.68E-02
2.68E-02
2.68E-02
2.69E-02
2.69E-02
2.69E-02
2.69E-02
2.69E-02
2.70E-02
2.71E-02
2.71E-02
2.72E-02
2.72E-02
2.73E-02
2.73E-02
2.73E-02
2.73E-02
2.73E-02
2.73E-02
2.74E-02
2.74E-02
2.74E-02
2.74E-02
2.74E-02
2.74E-02
2.74E-02
2.75E-02
2.76E-02
2.76E-02
2.76E-02
2.76E-02
2.77E-02
2.77E-02
2.77E-02
2.77E-02
2.77E-02
2.78E-02
2.78E-02
2.78E-02
2.78E-02
2.79E-02
2.80E-02
2.80E-02
2.80E-02
2.81E-02
2.81E-02
2.81E-02
2.81E-02
2.81E-02
2.81E-02
2.81E-02
2.82E-02
2.82E-02
2.83E-02
2.83E-02
2.83E-02
2.83E-02
2.84E-02
2.84E-02
2.85E-02
2.85E-02
2.85E-02
2.86E-02
2.86E-02
2.86E-02
2.87E-02
2.87E-02
2.87E-02
2.87E-02
2.87E-02
2.88E-02
33655
48802
59736
27554
4713
12615
28008
6989
34673
36924
33624
57036
15858
38589
45926
41846
55402
59777
55937
3825
62100
1738
4280
17338
33421
43560
42178
1229
53544
60335
66696
38410
13732
2669
41019
11975
12540
32713
51132
60843
14221
28674
53007
35832
15395
31512
34485
57610
3865
39504
41918
10799
43865
68380
17369
52752
57045
30300
54251
57908
62956
43538
63446
12125
9344
7313
8811
12509
13205
47008
27214
19719
28866
8323
2510
42182
56579
11855
18296
65049
1098
9030
4870
16071
41586
2976
21950
35925
50394
33919
24240
34809
28055
33545
49955
60544
54449
4376
30173
66947
41195
10801
18153
34300
2982
43675
25138
28087
65184
45127
52908
59734
8645
52698
67621
39446
28491
16522
29216
44572
54414
51280
56245
34163
34899
24731
13398
61791
44754
17668
55327
57466
52665
4427
33393
54637
40875
58929
32980
10580
39440
42871
48144
19743
40870
53416
64221
38451
63435
46212
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
83940
3700
51388
7732
5197
6332
8324
57010
8784
5151
116228
220929
84969
81559
57410
10376
133686
8480
283932
80254
55361
7318
7696
1106
8625
10573
140825
6880
11216
1797
9649
51477
2903
23317
219539
3914
57182
285672
5655
1397
1954
84318
113878
138474
64083
6229
9121
54900
9653
80778
54554
192669
51085
11078
199692
54585
3920
23126
212
3631
285016
51447
84529
26020
27013
90411
55234
8969
6482
25895
80323
29072
6439
90990
84519
3949
83694
126792
51110
79958
2483
29886
26071
56891
29066
60495
63035
147687
23616
51256
9940
23049
9612
1054
5264
197131
5260
58476
91768
26037
2747
4064
83451
2982
6712
29801
9672
55681
23786
154007
7037
5937
3903
5494
913
84869
6748
9410
2065
1539
339122
115948
26528
55106
83605
55258
80315
283464
1017
157680
64577
63948
373156
3991
319101
55365
201294
10290
56927
55154
11317
10916
11138
7123
5529
6786
168507
23515
8295
389677
TATDN1
ITIH4
NIP7
RNF112
PF4V1
SCN7A
FZD7
CABP4
TNFRSF18
PDE8A
COX20
ZNF438
TOX2
TRIM11
SCYL1
TUBA1B
NADK2
RAE1
FBXL19-AS1
CEP63
PI4K2A
UBA7
ZNF137P
CHD2
RFXANK
MRPL28
NEURL2
TAF9
AKAP10
DOM3Z
RALGPS1
ISYNA1
GRIN2A
DNAJC13
YPEL4
LAMB3
ANKRD50
SREK1IP1
KLK10
CRIP2
MEGF8
CCDC77
DTX2
TAF1L
GOLPH3
RPS24
SLC16A5
LAX1
HS2ST1
ZNF34
WDR5B
AGO3
MLXIPL
TRIOBP
ZNF627
LZTFL1
LAMP2
POGZ
ALAS2
INPP4A
FAM150B
IP6K2
C15orf41
LRP10
CNPPD1
MCFD2
SMU1
HIST1H2AG
ST3GAL1
METTL21B
CCDC68
SETD2
SFTPB
KIFC2
ACRBP
LDLR
RPS6KL1
B3GALT6
LACTB2
DENND1C
FRG1
SNX8
FAM127B
LGALS14
ZC3H7A
HPSE2
BCORL1
ZNF417
SH3BP1
TBC1D7
DLEC1
SMG1
NCOR2
CEBPG
PHYH
UBR1
PHKG1
TP53INP2
CABLES1
SIPA1L1
GLUD2
CD180
ABHD11
GUCY1A3
SPTBN2
ZDHHC8
SDC3
SCYL2
BCL2L13
SNRNP48
TFRC
RBMS1
LAIR1
PPM1A
CD1E
CBR4
SSR4
SNRNP40
ERBB3
CYLC2
RAB43
CCDC151
DAZAP1
SLFN12
CCM2
THNSL2
CPEB4
GXYLT1
CDK2
VPS13B
ALDH8A1
DMRTB1
GSTK1
LIPE
KRT73
TMEM176A
UNC13D
SPEG
GPR108
MSTO1
RBPJL
MAGED2
TBC1D8
CLEC3B
PPP2R5E
STIM1
PKD1L1
MORC3
TRRAP
RBM12B
--++-+
++--++
----++
+++?-+
+++-+++-+++
++-+++
++--++
-++-++
++-----++-+++++--++-+
++++-+
-----+
+------++---+--+
++-+++
--+-++--+-+
++--++
-------+?+-+++-+
-+++-+
-----+
-+----+--+-+--++-+-++
-+-++++++-+
++--++
+++++++-+++
+-+--+
----+--++++
+--+++
+-+--+
--+++++++++
----++
+----+
-----+
++++++
++---+
-++--++++-+
-----+-++-+
++--++
+---++
--+++--++-+-++-+
+-+--+
++-++++++-+
+-+++-+++-+
-+-?-++++-+
++-?++++-++
--++---+---+--+-----+
+++--+
-----++--++
+++--+
++-++++---+
++-+++
---+-+
+-++-++-+++
+-++-+
-+-+++
-+++++
++++++
+----++-+++
+-+--+
+--+-++-+-+
--++-+
++-+++
+-+-++---++
+-++++
---+-+
--++-++++-+
++++++++-++
-+-+-+
++-+++
+-------+-+
++-+++-++++
-----+
-+++++
+-+?--+---+-+--++---+-++++
+++?++
-++---+++++
--+-+---+-+
---+++
+-++++
++++---++-+
+-++++
-+---+
+-++++
+++-++
-+++++
+++++--+--+--+-++-+++
+++-++
++-+++
++-+++
-+-+-+
----++-++++
+++--+
++++-+
+++-++
--+--+
++++++
+-+-++
+--?++
-++-++
----+++++-+
+++-++
--+--+----+
--+++-
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
-2.187
2.186
-2.186
2.185
2.185
2.185
2.185
2.184
2.184
-2.184
-2.183
2.183
-2.182
2.182
-2.182
-2.182
-2.182
-2.182
2.181
-2.18
2.18
2.18
-2.179
-2.179
2.179
2.179
-2.178
-2.178
-2.178
-2.178
2.177
-2.176
2.176
2.175
2.174
2.174
2.174
-2.173
2.173
2.173
2.173
-2.173
2.173
-2.172
2.172
-2.172
2.172
2.172
-2.171
2.171
-2.17
2.167
2.167
2.164
-2.164
-2.163
2.163
2.162
2.162
2.161
2.161
2.161
-2.161
2.16
2.16
2.159
-2.159
-2.158
-2.159
-2.158
2.158
-2.156
2.156
2.156
2.156
2.155
2.154
-2.154
-2.154
2.153
2.151
2.149
2.148
2.148
-2.148
2.147
2.147
-2.146
2.146
2.145
2.145
-2.145
2.144
2.144
-2.144
-2.144
2.144
2.143
2.143
2.143
2.142
-2.141
2.141
2.14
2.139
-2.137
2.137
-2.137
-2.137
-2.137
-2.136
2.136
2.135
-2.135
2.135
-2.135
-2.135
-2.134
2.134
2.134
-2.134
2.133
-2.133
2.132
2.131
2.131
2.131
-2.131
-2.13
2.13
2.13
2.13
2.129
-2.129
-2.128
2.128
2.128
2.128
2.127
-2.127
2.127
2.126
2.126
2.126
-2.126
2.125
2.125
-2.125
-2.124
-2.123
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.88E-02
2.88E-02
2.89E-02
2.89E-02
2.89E-02
2.89E-02
2.89E-02
2.89E-02
2.90E-02
2.90E-02
2.90E-02
2.91E-02
2.91E-02
2.91E-02
2.91E-02
2.91E-02
2.91E-02
2.91E-02
2.92E-02
2.92E-02
2.93E-02
2.93E-02
2.93E-02
2.93E-02
2.93E-02
2.94E-02
2.94E-02
2.94E-02
2.94E-02
2.94E-02
2.95E-02
2.95E-02
2.96E-02
2.96E-02
2.97E-02
2.97E-02
2.97E-02
2.98E-02
2.98E-02
2.98E-02
2.98E-02
2.98E-02
2.98E-02
2.98E-02
2.98E-02
2.99E-02
2.99E-02
2.99E-02
2.99E-02
3.00E-02
3.00E-02
3.02E-02
3.02E-02
3.05E-02
3.05E-02
3.05E-02
3.05E-02
3.06E-02
3.06E-02
3.07E-02
3.07E-02
3.07E-02
3.07E-02
3.08E-02
3.08E-02
3.08E-02
3.09E-02
3.09E-02
3.09E-02
3.09E-02
3.09E-02
3.11E-02
3.11E-02
3.11E-02
3.11E-02
3.12E-02
3.12E-02
3.12E-02
3.13E-02
3.14E-02
3.15E-02
3.17E-02
3.17E-02
3.17E-02
3.17E-02
3.18E-02
3.18E-02
3.19E-02
3.19E-02
3.19E-02
3.20E-02
3.20E-02
3.20E-02
3.20E-02
3.20E-02
3.20E-02
3.20E-02
3.21E-02
3.21E-02
3.22E-02
3.22E-02
3.23E-02
3.23E-02
3.24E-02
3.25E-02
3.26E-02
3.26E-02
3.26E-02
3.26E-02
3.26E-02
3.27E-02
3.27E-02
3.27E-02
3.27E-02
3.27E-02
3.28E-02
3.28E-02
3.28E-02
3.28E-02
3.29E-02
3.29E-02
3.29E-02
3.30E-02
3.30E-02
3.31E-02
3.31E-02
3.31E-02
3.31E-02
3.32E-02
3.32E-02
3.32E-02
3.32E-02
3.32E-02
3.33E-02
3.33E-02
3.33E-02
3.33E-02
3.34E-02
3.34E-02
3.34E-02
3.34E-02
3.35E-02
3.35E-02
3.35E-02
3.35E-02
3.36E-02
3.36E-02
3.36E-02
3.37E-02
3.37E-02
61798
8456
12937
41706
41537
17692
26222
16730
27236
39426
40660
696
29061
65973
40197
54393
27242
43698
22146
62865
11648
60871
28810
36031
48002
16893
31963
49761
47981
17822
40258
45334
14544
8270
17905
64346
18495
46408
57116
10815
22618
36572
31394
42683
24952
22750
10226
15519
38077
22794
55238
17887
1027
46689
10156
29171
63147
57733
3501
28227
14037
42620
9966
60766
54445
22933
36082
8009
21922
20616
11037
64234
37158
61678
2534
23190
31647
13518
57156
64245
24632
19776
42523
54243
47615
65262
28006
57890
17718
67053
34021
25579
20186
63704
12987
9465
27216
4397
59311
1293
18604
637
59301
62080
762
65214
17725
26555
53999
10072
9357
32763
1963
31290
29145
3179
41359
62971
16076
62312
41996
13677
10335
30870
2159
16100
21392
401
65215
47417
16083
38
32992
41529
11555
66366
64179
11386
35646
61312
55209
10364
62415
25884
64170
39578
64582
48985
5909
39007
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
7525
4287
23392
147906
4357
26100
8509
10611
55293
8019
441194
1666
4733
84433
84913
284217
8624
6733
375686
9603
2959
10322
6815
129831
51696
537
140883
3939
55589
64283
79875
6389
10456
4650
29952
147991
649
28998
140032
92856
4082
83990
29956
4585
79618
64344
7584
27032
79959
23199
55690
1428
54737
10102
6843
79663
129685
659
10921
64174
24140
7320
56997
3115
2592
81689
338785
90338
1659
56851
1486
2870
192683
27297
526
197358
63899
10884
401472
10677
5558
23254
79170
4207
27120
8496
23764
9528
7763
29926
56889
10402
10922
30846
79970
219293
7975
3732
10495
158427
10810
55876
55739
3300
399979
51292
3021
51006
84243
83932
85395
25771
4125
10865
54952
7380
403341
25893
80764
25764
7727
6567
26297
9444
54621
6903
55223
54106
388272
286234
50613
400242
64421
79991
22846
5191
84148
8798
9043
5339
51566
55835
643036
10767
27130
128077
5440
80317
339451
81168
YES1
ATXN3
KIAA0368
DACT3
MPST
WIPI2
NDST2
PDLIM5
UEVLD
BRD3
PMS2CL
DECR1
DRG1
CARD11
ATOH8
LAMA1
PSMG1
SRPK2
SPATC1
NFE2L3
GTF2B
SMYD5
STYX
RBM45
HECA
ATP6AP1
ZNF280B
LDHA
BMP2K
ARHGEF28
THSD4
SDHA
HAX1
MYO9B
DPP7
DPY19L3
BMP1
MRPL13
RPS4Y2
IMP4
MARCKS
BRIP1
CERS2
MUC4
HMBOX1
HIF3A
ZNF35
ATP2C1
CEP76
GSE1
PACS1
CRYM
MPHOSPH8
TSFM
VAMP1
HSPBAP1
TAF8
BMPR2
RNPS1
DPEP2
FTSJ1
UBE2B
ADCK3
HLA-DPB1
GALT
ISCA1
KRT79
ZNF160
DHX8
EMC7
CTBS
GRK6
SCAMP5
CRCP
ATP6V1B2
NLRC3
NSUN3
MRPS30
FLJ45248
AVIL
PRIM2
KAZN
PRR15L
MEF2BNB-MEF2B
DKKL1
PPFIBP1
MAFF
TMEM59
ZFAND5
GMPPA
TM9SF3
ST3GAL6
FASTK
EHD2
ZNF767
ATAD3C
MAFK
CD82
ENOX2
TSTD2
WASF3
GSDMB
CARKD
DNAJB2
SNX19
GMPR2
H3F3B
SLC35C2
ZDHHC18
SPRTN
FAM207A
TBC1D22A
MAN2B1
ARID5A
TRNAU1AP
UPK3A
ZBTB34
TRIM58
THAP7
HYPK
ZNF174
SLC16A2
SERGEF
QKI
VSIG10
TBCC
TRIM62
TLR9
C16orf87
SPATA31E1
UBQLN3
DICER1-AS1
DCLRE1C
OBFC1
VASH1
PEX7
KAT8
DYRK4
SPAG9
PLEC
ARMCX3
CENPJ
SLED1
HBS1L
INVS
LIX1L
POLR2K
ZKSCAN3
KLHL17
OR8J3
--++---++-++++++
++-++++++-+
++-+-+
-+-+++
+++--+
+-++-+
++-+-+
-----+
+-++-+
---+-++--++-++++
+++-++
---+--++?++
++-?++
+-++-+
--+-+-----++-++--+--+-+--+++--+
-----+-++++
+++++++-+-+
-+-+++
-+--++
-----+
+++--+
-+--++
+-+--+
++---+
--++----------++
+-+--++---++++-+
-+++++
--++-+
-+++++
+-++++
+----++---++---+
-+---+-+-++
+---+-+++------+
+-++++
--+--+
+-++-+
-----+
--+--+
---+-+-+-------+
---+++
+---++++-+--++++
++++++-++-+
+-++++
++++++
-+++-+
--+--+
+++-++
-++?-+
++-+++
+++++---+-+++-++
+++-++
----++
--+-++
++++++
+++--+
++++++
++--+---+---++++
+-+---+-+++
+-+----+--+
---+-+
+-++++
-+-?++++--+
-+++++
+++?-+
---+-+
--+-+++-+++---+----++
++-+++--+++
+-+-++
+-+?------+
+++--+
-----+
---+--+++-+
-+-?-+
+++-++
+-+-++
+++?-+
+++-+++-++-+---+
+---------+
+++-++
---+-+
+++?-+
+-++++
-++-++
-+-+-+
---+-+
-----++--++
++++++
-----+++?+-++++++-+++
--+-------+
---?-+
+++-+++--++
+----+-+?--+++-+
--++------+----+
++++++
--++-+
-+-+++
-+++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
-2.123
-2.123
2.122
2.122
2.121
2.121
2.121
2.12
2.12
2.12
-2.12
2.119
-2.119
-2.119
2.118
2.118
-2.116
2.116
2.116
2.116
-2.115
-2.115
-2.115
-2.113
-2.113
2.113
-2.112
2.112
2.112
2.112
2.112
2.112
-2.111
2.11
2.11
2.108
2.108
-2.107
-2.106
-2.106
-2.105
-2.105
2.105
2.104
2.103
2.103
2.103
-2.103
-2.102
2.101
-2.101
2.101
-2.101
-2.101
-2.1
2.1
2.099
2.098
-2.098
-2.098
-2.098
-2.097
-2.097
2.096
-2.096
-2.096
2.095
2.094
2.094
2.093
2.093
2.093
-2.093
2.093
2.093
2.092
2.092
-2.091
2.091
2.09
-2.09
2.09
2.089
2.089
2.088
-2.088
-2.088
2.087
-2.087
2.086
-2.086
2.085
-2.085
2.085
-2.084
2.084
2.084
2.083
-2.083
-2.083
2.082
-2.082
-2.082
2.081
2.08
2.08
-2.08
-2.08
2.079
-2.079
-2.078
2.078
2.077
2.076
2.076
2.074
2.073
2.073
-2.073
-2.073
-2.072
2.071
-2.07
2.07
2.07
2.069
2.069
-2.069
-2.068
2.068
2.067
-2.066
2.066
2.066
2.066
-2.066
-2.065
-2.065
2.065
2.065
-2.064
-2.063
2.063
-2.063
-2.063
-2.063
2.062
-2.061
2.06
2.058
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3.37E-02
3.38E-02
3.38E-02
3.38E-02
3.39E-02
3.39E-02
3.40E-02
3.40E-02
3.40E-02
3.41E-02
3.41E-02
3.41E-02
3.41E-02
3.41E-02
3.42E-02
3.42E-02
3.43E-02
3.44E-02
3.44E-02
3.44E-02
3.44E-02
3.44E-02
3.44E-02
3.46E-02
3.46E-02
3.46E-02
3.46E-02
3.46E-02
3.47E-02
3.47E-02
3.47E-02
3.47E-02
3.48E-02
3.49E-02
3.49E-02
3.50E-02
3.51E-02
3.51E-02
3.52E-02
3.53E-02
3.53E-02
3.53E-02
3.53E-02
3.54E-02
3.54E-02
3.55E-02
3.55E-02
3.55E-02
3.56E-02
3.56E-02
3.56E-02
3.57E-02
3.57E-02
3.57E-02
3.57E-02
3.57E-02
3.58E-02
3.59E-02
3.59E-02
3.59E-02
3.59E-02
3.60E-02
3.60E-02
3.61E-02
3.61E-02
3.61E-02
3.62E-02
3.62E-02
3.63E-02
3.63E-02
3.63E-02
3.63E-02
3.64E-02
3.64E-02
3.64E-02
3.64E-02
3.65E-02
3.65E-02
3.65E-02
3.66E-02
3.66E-02
3.67E-02
3.67E-02
3.67E-02
3.68E-02
3.68E-02
3.68E-02
3.69E-02
3.69E-02
3.70E-02
3.70E-02
3.70E-02
3.70E-02
3.71E-02
3.71E-02
3.72E-02
3.72E-02
3.72E-02
3.72E-02
3.72E-02
3.73E-02
3.73E-02
3.73E-02
3.74E-02
3.75E-02
3.75E-02
3.75E-02
3.76E-02
3.76E-02
3.77E-02
3.77E-02
3.77E-02
3.78E-02
3.79E-02
3.79E-02
3.81E-02
3.82E-02
3.82E-02
3.82E-02
3.82E-02
3.82E-02
3.84E-02
3.84E-02
3.84E-02
3.85E-02
3.85E-02
3.86E-02
3.86E-02
3.86E-02
3.87E-02
3.88E-02
3.88E-02
3.88E-02
3.88E-02
3.88E-02
3.88E-02
3.89E-02
3.89E-02
3.89E-02
3.89E-02
3.90E-02
3.91E-02
3.91E-02
3.91E-02
3.91E-02
3.92E-02
3.92E-02
3.93E-02
3.94E-02
3.96E-02
19568
22617
29459
18574
40423
21244
58807
31663
40570
66196
67049
32398
57897
44222
36055
51780
27372
18658
54818
66463
34156
36505
16191
58198
7378
6428
55164
38268
48528
55001
38654
26110
51551
67585
67747
60842
51993
45045
41975
12341
63828
33468
68522
56202
17613
21521
45768
35105
6730
26657
53066
48472
38689
22096
21414
35871
12572
57126
1935
53437
50367
22349
31577
37654
42241
149
12113
58287
17341
42967
11776
2232
4598
59662
62833
7012
15522
21342
6916
24371
51813
37876
44670
31986
62211
22159
20703
18805
4852
40803
26664
35417
7223
63316
54002
52540
30203
16185
55311
63085
8429
36034
14505
6348
16281
37360
42428
18071
24381
27600
15870
55307
45520
50660
1616
43085
29879
21261
24039
3511
8738
3329
57758
6654
62123
36071
44615
32164
48425
12720
2428
19623
55313
44449
44407
37829
23578
40625
36984
64982
8498
35739
59160
61022
4423
40216
59215
6298
64183
9922
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
5739
25843
8396
902
113691
55421
10219
2242
27315
782
9612
54946
219833
8498
129531
26984
6653
2068
387032
9382
5002
91687
339487
91522
51490
51076
5605
8872
3441
5989
2635
80832
80142
1795
83416
91289
6854
57117
79979
9567
3687
9656
139324
23275
554206
10987
10318
10544
10247
90121
1676
115817
9569
90324
8349
64118
91137
55363
7692
129684
64225
3281
10421
404217
139760
5526
23295
80308
118424
55600
1856
2965
813
338917
4175
5995
3601
55756
79720
91526
5564
92400
64843
7064
9276
93100
4728
2042
23524
143098
23509
124912
1460
1000
3671
9681
5261
84153
740
11171
2352
25880
4824
84992
10778
2907
8702
79174
51150
55337
5684
10239
155465
140578
54974
257044
85403
63941
9491
497661
51182
390038
6605
9098
91695
6196
1384
147929
129607
9654
7559
2187
140606
140831
84901
10383
5095
9077
1349
4496
79634
9920
10483
22900
51510
9695
23265
3676
388
137492
PTGIR
MOB4
PIP4K2B
CCNH
TUBA3FP
C17orf85
KLRG1
FES
PGAP2
CACNB1
NCOR2
SLC41A3
C11orf45
RANBP3
MITD1
SEC22A
SORL1
ERCC2
ZKSCAN4
COG1
SLC22A18
CENPL
ZBTB8OS
COL23A1
C9orf114
CUTC
MAP2K2
CDC123
IFNA4
RFX1
GBP3
APOL4
PTGES2
DOCK3
FCRL5
LMF2
SYN2
INTS12
TRMT2B
GTPBP1
ITGAX
MDC1
HDX
POFUT2
LOC554206
COPS5
TNIP1
PROCR
HRSP12
TSR2
DFFA
DHRS1
GTF2IRD1
CCDC97
HIST2H2BE
DUS1L
SLC25A46
HEMGN
ZNF133
CNTNAP5
ATL2
HSBP1
CD2BP2
CTXN1
GPR119
PPP2R5B
MGRN1
FLAD1
UBE2J2
ITLN1
DVL2
GTF2H1
CALU
VSX2
MCM6
RGR
IL15RA
INTS9
VPS37B
ANKRD44
PRKAB1
RBM18
ISL2
THOP1
COPB2
NAPRT1
NDUFS8
EPHA3
SRRM2
MPP7
POFUT1
SPACA3
CSNK2B
CDH2
ISLR
DEPDC5
PHKG2
RNASEH2C
MRPL49
STRAP
FOLR3
TMEM186
NKX3-1
PIGY
ZNF271
GRINA
B4GALT4
CRELD2
SDF4
C19orf66
PSMA3
AP3S2
AGR3
CHODL
THG1L
C1orf101
EAF1
NECAB3
PSMF1
C18orf32
HSPA14
OR51D1
SMARCE1
USP6
RRP7B
RPS6KA2
CRAT
ZNF565
CMPK2
TTLL4
ZNF12
FANCB
RP3-412A9.11
ZSWIM3
NFATC2IP
TUBB4B
PCCA
DIRAS3
COX7B
MT1H
SCRN3
KBTBD11
SEC23B
CARD8
CHMP5
EDEM1
EXOC7
ITGA4
RHOB
VPS37A
++-+++
---++---+-+-++++
+++--+
+----++-?++
-+++-+
-----+
++++-+
++---+
-----+
++-+++
-----+
--+-+-----+++++----++
-----+
-+--++++--+
--+-+++++++
++--++
----+--++-+++?++
+-+++++--++
++-+-+
++++-+
+--+++
--++----+-+--+++
++---+
+-++-----+---+++--+-+
++++++
-----+
-+++++
+++?++
---+---+?++++--+
+-+?++
---++----+-+---+
++-+++
++++++
++++-+
--+---+-+---+--++-++-----+
++++-+
+-+--+++++-+-+++
++--++
--++-+
++-++++++-+
++-+++
--++++
+++++++-+-+
--++------+
++-+-+
+---++++-++
++++-+
---+-+
+++-++
+-++++
++++-+
+-++++
++++-+
-----+-++++
++++-+
---+-+
+-+-++
----+-++++-----+
-+++-+
-+-+++
+-+++++++++
-+-+-+
++-+-+
-+-+++
-+---+
--++-+-++-+
-----+
--+----++-++++-++-++-----+
----++
+++-++
++-+++
--++-+--+-+
+---++
+-++++
--+--+
---+-+-++-+
++++++
+--++++++---+-+-+-+++
--+--+
+-++-+
---+-+
++++-+
++-++---+-++++-+
+++--+
--+?-+--++-----+
-----+
++++-+
+++-+--++---++++
+-+++-+-+++
--+?---++-+
-----+
+-++-+
++++++----++-+++
+-+--+-++-+
--++--
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
2.058
-2.057
-2.057
2.057
2.057
-2.056
2.056
2.055
-2.054
2.054
2.053
-2.053
2.052
-2.052
-2.052
-2.052
2.051
-2.051
-2.051
-2.05
2.05
-2.05
2.049
2.049
-2.048
-2.048
2.048
-2.048
2.047
2.047
2.047
2.047
-2.046
-2.046
2.045
2.045
2.044
-2.043
-2.042
2.041
2.041
-2.04
2.04
2.04
-2.039
-2.039
2.038
2.038
-2.038
-2.036
-2.036
2.035
2.035
2.034
-2.034
-2.034
-2.034
-2.032
-2.032
2.032
-2.031
2.031
2.031
2.031
2.031
2.03
2.03
2.03
2.029
2.029
2.028
-2.028
-2.028
2.028
-2.027
2.027
2.027
-2.027
2.026
2.026
2.025
2.025
2.025
-2.024
2.024
2.024
-2.023
2.023
-2.022
2.022
-2.021
2.021
2.021
2.02
2.02
2.019
2.019
2.018
-2.019
-2.018
2.018
-2.018
-2.017
-2.017
-2.017
2.016
-2.016
-2.016
2.015
2.015
-2.014
2.014
2.014
2.014
-2.014
-2.013
2.013
2.012
-2.01
2.009
-2.008
2.008
-2.007
2.007
-2.005
2.005
2.005
-2.004
2.003
2.003
-2.003
-2.001
-2.001
-2
2
1.999
-1.999
1.998
1.998
1.997
-1.997
-1.997
-1.997
1.997
1.996
-1.996
1.996
-1.996
1.995
-1.995
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
3.96E-02
3.97E-02
3.97E-02
3.97E-02
3.97E-02
3.98E-02
3.98E-02
3.98E-02
4.00E-02
4.00E-02
4.00E-02
4.01E-02
4.01E-02
4.01E-02
4.02E-02
4.02E-02
4.02E-02
4.02E-02
4.03E-02
4.03E-02
4.04E-02
4.04E-02
4.04E-02
4.05E-02
4.05E-02
4.06E-02
4.06E-02
4.06E-02
4.07E-02
4.07E-02
4.07E-02
4.07E-02
4.07E-02
4.08E-02
4.09E-02
4.09E-02
4.09E-02
4.11E-02
4.11E-02
4.12E-02
4.13E-02
4.13E-02
4.13E-02
4.14E-02
4.14E-02
4.14E-02
4.16E-02
4.16E-02
4.16E-02
4.17E-02
4.17E-02
4.18E-02
4.19E-02
4.19E-02
4.20E-02
4.20E-02
4.20E-02
4.21E-02
4.21E-02
4.21E-02
4.22E-02
4.23E-02
4.23E-02
4.23E-02
4.23E-02
4.23E-02
4.23E-02
4.24E-02
4.25E-02
4.25E-02
4.25E-02
4.25E-02
4.26E-02
4.26E-02
4.27E-02
4.27E-02
4.27E-02
4.27E-02
4.27E-02
4.28E-02
4.28E-02
4.29E-02
4.29E-02
4.29E-02
4.30E-02
4.30E-02
4.30E-02
4.31E-02
4.31E-02
4.32E-02
4.33E-02
4.33E-02
4.33E-02
4.34E-02
4.34E-02
4.34E-02
4.35E-02
4.35E-02
4.35E-02
4.36E-02
4.36E-02
4.36E-02
4.37E-02
4.37E-02
4.37E-02
4.38E-02
4.38E-02
4.39E-02
4.39E-02
4.39E-02
4.40E-02
4.40E-02
4.41E-02
4.41E-02
4.41E-02
4.41E-02
4.41E-02
4.42E-02
4.44E-02
4.46E-02
4.46E-02
4.47E-02
4.47E-02
4.48E-02
4.49E-02
4.50E-02
4.50E-02
4.50E-02
4.51E-02
4.52E-02
4.52E-02
4.54E-02
4.54E-02
4.55E-02
4.55E-02
4.56E-02
4.56E-02
4.57E-02
4.57E-02
4.58E-02
4.58E-02
4.58E-02
4.59E-02
4.59E-02
4.59E-02
4.59E-02
4.59E-02
4.59E-02
4.60E-02
4.61E-02
11545
58813
24125
46315
10991
54352
19160
16510
66607
19896
39196
46164
68338
31558
17011
55533
562
59513
31200
46063
25571
29649
50065
41416
26286
25908
26072
43158
42336
856
21009
22991
33479
52029
64120
36420
43138
28480
25749
25112
14224
33996
67939
40794
3312
64510
21608
66879
44499
53749
23234
37832
40688
41150
5551
2113
28210
37716
29165
32414
45996
2194
57483
11896
44501
21052
49538
23939
27108
35623
27201
36884
18918
1858
31343
14560
31597
48768
38737
63783
7241
43502
15227
40447
65092
12735
59329
21688
21011
38134
27191
10410
38815
55173
11205
59536
29974
52941
19231
62569
64410
68193
45529
30829
24358
59863
22378
31321
26937
19227
55690
29197
44622
14661
7496
63054
58434
30938
35666
42902
54283
20708
3366
20092
27932
3090
39892
48368
13970
32776
25789
51444
54766
61005
67847
47494
52121
27499
33897
22693
14692
693
46376
61348
21010
20232
54308
66920
46110
2531
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
7678
57143
51115
7127
1233
96610
115024
1997
64785
80207
116362
84124
997
221545
29127
2944
8973
27285
1140
9768
8655
128
23401
3123
43
962
23197
1161
5716
359948
6050
4709
146712
3980
60491
22911
122618
55809
2657
9235
522
7704
10463
51293
5825
114880
6738
1399
10163
9651
3839
2746
1036
317701
54988
2181
51298
53405
10955
6902
1024
57699
29888
85363
139741
124460
23221
140290
55821
8910
51506
727
84254
200942
388341
23087
57348
79716
6433
5906
1762
225689
266727
127064
84687
50801
4913
3385
93323
25805
966
9562
914
25927
8339
56986
7272
60672
11093
79087
10920
149373
283232
55132
123775
2582
55582
5863
55294
55667
202459
23400
3433
4247
51046
27010
7465
131578
90589
113828
128989
388007
551
22807
5814
57827
124565
84285
64130
3621
127018
1261
83479
404037
5713
7307
9929
55177
10521
10664
8351
84445
114885
9282
11065
147700
5971
114771
9133
64403
ZNF124
ADCK1
RMDN1
TNFAIP2
CCR4
LL22NC03-80A10.6
NT5C3B
ELF1
GINS3
OPA3
RBP7
ZNF394
CDC34
C6orf136
RACGAP1
GSTM1
CHRNA6
TEKT2
CHRNB1
KIAA0101
DYNLL1
ADH5
FRAT2
HLA-DRB1
ACHE
CD48
FAF2
ERCC8
PSMD10
IRF2BP2
RNH1
NDUFB3
B3GNTL1
LIG3
NIF3L1
WDR47
PLD4
TRERF1
GDF1
IL32
ATP5J
ZBTB16
SLC30A9
CD320
ABCD3
OSBPL6
TROVE2
CRKL
WASF2
PLCH2
KPNA3
GLUD1
CDO1
VN1R2
ACSM5
ACSL3
THEG
CLIC5
SERINC3
TBCA
CDK8
CPNE5
STRN4
TRIM5
ACTRT1
SNX20
RHOBTB2
TCP10L
ALLC
SGCE
UFC1
C5
CAMKK1
KLHDC8B
FAM211A
TRIM35
TTYH1
NPEPL1
SFSWAP
RAP1A
DMWD
MAPK15
MDGA1
OR2T12
PPP1R9B
KCNK4
NTHL1
ICAM3
HAUS8
BAMBI
CD59
MINPP1
CD2
CNRIP1
HIST1H2BG
DTWD1
TTK
MIIP
ADAMTS13
ALG12
COPS8
RP5-1097F14.3
TMEM80
LARP1B
C16orf46
GALE
KIF27
RGL2
FBXW7
DENND4C
OSTCP1
ATP13A2
IFIT2
MGAT2
ST8SIA3
TPK1
WEE1
LRRC15
ZNF625
FAM83F
TANGO2
SERPINA13P
AVP
IKZF2
PURB
C6orf47
SLC38A10
EIF1AD
LIN7B
ING1
LYPLAL1
CNGA3
DDX59
HAPLN4
PSMD7
U2AF1
JOSD1
RMDN3
DDX17
CTCF
HIST1H3D
LZTS2
OSBPL11
MED14
UBE2C
KLC3
RELB
PGLYRP3
CCNB2
CDH24
--++------+
+-+--++++-+
++--+------------+-------+
-----+
--++-+
+++--+
++++++----+--+-+
-----+
--++++
+-++++
--++----+-+++++--++-+-+---+--++-++++
--++----+-+
--+-+--+-+++-+-+
-+--++
++++++-+--+
-+-+-+
---?-+
+-+-++
-+++++
++++-+
+-++++
++--+-+-----++++
+-+?-++-+++
------+---+
-+++++----+
+++?-+
++--++
--++-+-++-+++-++
-+++-+
-+-+++
--++++
+-+?++
+----++++-+
---+-+
+--+++---++++--+
++++-+++-++-++-+
--+-++
+++--+
-+--++
++--++
---++--++++
++--++
-+++-+
++-+++
---+-+
+++--+
++-+++
-------++-++-+-+
-+--++
+++-++
++-++++-+++
++++-+
-+---+
+++--+
+----++++++
+-+-++++?-++-+++
-+++++
-------+++--+--+-+-++
+--+++
+++-++
-----+++-++
--+?-+
-+++-+--+++
++--++
+-+-++
+++--+
+-+--++-+-+++--+
-+---+
++++-+
+-+--++---+
+-++++
+--+-+
++++++
++++++
++-+++
++-++++-++++--++
-++?+--+--+
++++-+
++--++
--++-+
---?---+?-+
-++++++++++
+-++++
++--++
---+-+
-+++-++-+-+
++-?++
+++-++
----+--++-+
-----+
++++-+
-+----+++++
+++++++++++
----+---+-+
+-++-+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-1.995
-1.995
-1.994
1.993
1.992
-1.992
-1.991
-1.991
-1.991
-1.99
1.99
1.99
1.99
-1.989
1.989
-1.988
1.987
1.986
-1.986
-1.986
1.985
-1.984
-1.984
-1.983
1.983
-1.983
-1.982
-1.981
-1.981
1.981
1.981
1.981
1.98
-1.98
-1.98
1.98
1.98
1.979
1.978
-1.978
-1.978
1.978
-1.976
1.975
-1.975
1.975
1.974
-1.974
1.974
1.974
-1.973
-1.973
1.972
1.972
1.971
1.97
1.97
-1.97
1.969
-1.969
-1.969
-1.969
1.968
1.967
1.967
1.967
1.966
1.966
1.966
1.966
-1.966
1.966
1.965
1.965
1.965
-1.965
1.965
1.965
-1.964
-1.964
1.963
1.963
1.962
1.962
1.962
1.961
-1.961
1.961
-1.96
1.96
-1.96
-1.959
1.959
1.959
-1.959
-1.958
-1.958
1.958
1.958
1.957
-1.957
1.956
1.955
-1.955
1.955
1.955
1.955
1.955
-1.954
-1.954
1.953
1.953
1.952
-1.952
1.952
1.952
1.952
1.951
1.951
1.95
1.95
1.95
1.949
-1.949
-1.948
1.947
1.947
1.947
-1.947
-1.947
1.946
1.946
1.946
1.946
-1.945
-1.945
1.944
1.943
1.943
-1.941
1.94
-1.939
1.939
-1.939
1.939
1.938
1.938
-1.938
-1.938
1.937
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4.61E-02
4.61E-02
4.61E-02
4.62E-02
4.64E-02
4.64E-02
4.65E-02
4.65E-02
4.65E-02
4.66E-02
4.66E-02
4.66E-02
4.66E-02
4.67E-02
4.67E-02
4.68E-02
4.70E-02
4.70E-02
4.70E-02
4.70E-02
4.72E-02
4.73E-02
4.73E-02
4.74E-02
4.74E-02
4.74E-02
4.75E-02
4.75E-02
4.76E-02
4.76E-02
4.76E-02
4.76E-02
4.77E-02
4.77E-02
4.77E-02
4.77E-02
4.77E-02
4.78E-02
4.79E-02
4.79E-02
4.79E-02
4.79E-02
4.82E-02
4.82E-02
4.82E-02
4.83E-02
4.83E-02
4.83E-02
4.84E-02
4.84E-02
4.85E-02
4.85E-02
4.86E-02
4.86E-02
4.87E-02
4.88E-02
4.89E-02
4.89E-02
4.89E-02
4.89E-02
4.89E-02
4.90E-02
4.91E-02
4.91E-02
4.92E-02
4.92E-02
4.93E-02
4.93E-02
4.93E-02
4.93E-02
4.93E-02
4.93E-02
4.94E-02
4.94E-02
4.94E-02
4.94E-02
4.94E-02
4.94E-02
4.95E-02
4.95E-02
4.97E-02
4.97E-02
4.98E-02
4.98E-02
4.98E-02
4.99E-02
4.99E-02
4.99E-02
4.99E-02
4.99E-02
5.00E-02
5.01E-02
5.01E-02
5.01E-02
5.02E-02
5.02E-02
5.02E-02
5.02E-02
5.02E-02
5.03E-02
5.04E-02
5.04E-02
5.05E-02
5.05E-02
5.06E-02
5.06E-02
5.06E-02
5.06E-02
5.07E-02
5.08E-02
5.09E-02
5.09E-02
5.09E-02
5.09E-02
5.09E-02
5.10E-02
5.10E-02
5.10E-02
5.10E-02
5.11E-02
5.12E-02
5.12E-02
5.13E-02
5.13E-02
5.15E-02
5.15E-02
5.16E-02
5.16E-02
5.16E-02
5.16E-02
5.16E-02
5.16E-02
5.16E-02
5.17E-02
5.18E-02
5.18E-02
5.19E-02
5.20E-02
5.21E-02
5.22E-02
5.23E-02
5.25E-02
5.25E-02
5.25E-02
5.25E-02
5.26E-02
5.26E-02
5.27E-02
5.27E-02
5.27E-02
12348
13550
60614
56278
33440
34389
14687
45580
42430
45209
36053
59424
4248
25761
2456
17180
65881
11995
20570
12391
8339
38633
42931
22118
44637
16470
2767
36956
28888
64449
16432
37810
36668
29885
21328
41914
14976
21127
25756
901
64768
38466
12435
48329
6089
35904
59545
40559
49872
35192
51342
62022
29735
7993
36149
48508
39123
22943
52395
8897
15529
27402
62729
3095
5665
42727
68278
43119
33452
7551
38254
25963
15393
18381
38464
37176
38067
13880
25154
3611
11244
50345
46041
15768
47259
63088
60232
16938
38712
12267
41762
5494
46254
48186
31974
46348
52105
50385
57700
60528
35878
51963
10023
52979
25160
68277
12641
38895
16948
36840
19375
27560
23646
60600
45148
52407
28669
36629
58416
53568
11934
60133
9168
65249
488
59309
58005
13694
66304
57899
33441
41538
41842
46647
44454
64219
37648
68350
61305
63049
10746
52596
34070
7239
27077
43465
15376
18062
25313
56444
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
79414
27230
10044
199221
9694
7581
5000
84872
9409
5537
163259
57472
143872
8220
79885
5016
8766
54505
23305
11151
23416
55083
6728
55088
51529
201965
653583
11126
60484
2235
2664
4706
285908
10256
57162
53826
3087
10842
10670
98
3005
54883
3955
80218
2710
133923
55157
3815
10302
56244
170679
956
8487
6911
3842
55870
79924
93974
10507
84229
84561
57210
7866
79109
7852
79697
54904
145165
25851
10052
10678
54793
79004
138199
8968
162239
186
1967
79018
10607
55766
55291
57119
5550
136
9053
3211
113675
4780
51385
170062
132241
401541
9764
248
7286
285527
7090
726
3362
4641
828
222235
10202
6338
78999
6094
4335
3643
8799
79701
8538
4850
55196
57118
59348
4682
9600
83719
29965
374875
5892
149986
4855
5008
132884
4923
400511
60490
50809
56604
403
1735
23328
50856
7325
64981
93081
55683
113201
4802
51594
22924
401562
57333
9824
6464
29068
112858
3396
LRFN3
SERP1
SH2D3C
DZIP1L
EMC2
ZNF33A
ORC4
ZC3H10
PEX16
PPP6C
DENND2C
CNOT6
ARHGAP42
DGCR14
HDAC11
OVGP1
RAB11A
DHX29
ACSL6
CORO1A
KCNH3
KIF26B
SRP19
C10orf118
ANAPC11
RWDD4
PHLDB3
CD160
HAPLN2
FECH
GDI1
NDUFAB1
LINC00174
CNKSR1
PELI1
FXYD6
HHEX
PPP1R17
RRAGA
ACYP2
H1F0
CWC25
LFNG
NAA50
GK
ZNF474
DARS2
KIT
SNAPC5
BTNL2
PSORS1C1
ENTPD3
GEMIN2
TBX6
TNPO1
ASH1L
ADM2
ATPIF1
SEMA4D
CCDC135
SLC12A8
SLC45A4
IFRD2
MAPKAP1
CXCR4
C14orf169
WHSC1L1
ST13P4
TECPR1
GJC1
B3GNT2
KCTD9
CUEDC2
C9orf41
HIST1H3F
ZFP1
AGTR2
EIF2B1
GID4
TBL3
H2AFJ
PPP6R3
EPPIN
PREP
ADORA2B
MAP7
HOXB1
SDSL
NFE2L2
ZNF589
FAM47B
RPL32P3
CENPP
KIAA0513
ALPI
TUFT1
FRYL
TLE3
CAPN5
HTR6
MYO1C
CAPS
FBXL13
DHRS2
SCNN1B
LRFN4
ROM1
MNT
INSR
PEX11B
OGFOD3
BARX2
CNOT4
KIAA1551
CAMK1D
ZNF350
NUBP1
PITPNM1
YPEL3
CDIP1
HSD11B1L
RAD51D
LSM14B
NOTCH4
OSM
EVC2
NTSR1
FLJ45256
PPCDC
HP1BP3
TUBB7P
ARL3
DIO3
SASH1
CLEC4A
UBE2E2
MRPL34
TEX30
KANSL3
CASC4
NFYC
NBAS
MAPRE3
LCNL1
RCN3
ARHGAP11A
SHC1
ZBTB44
TP53RK
ICT1
++--++
--+?-+
++++-+
-++--+
---+---++---++--+++-+
-+++-+
--++-+-++-+----+++--+
-----+
+--+-+
---?++-+-++-+---+--+-+---+
-+++-+
++-+++
--+---+++--+-+++-+-------+
++++++
-+-+++
++++++++--+
---+-++++-+
--++++
+-+--+
+-++++
+-++-+
-+++++
---+++
++++++
+++++-++-++
++-+++
+-+?-+
+-+++-+++++
---+-+
--+-----+-+--+-+
++++++
-++++---++++++-+
-+-------+---+-+
-+++++
-----+
+-+?-+
+---++
+++------++
-+++++
--+--+
-----+--++-----+
-----+
+++--+
--+--+-----+-+-+
++++---+?-+
--++-++++-+
---+++
++-++-----+
+++---+--+++++++
--+?-+
+++++--+--+
-+++-+
++++++-++------+
++--++
+-+--+
+-+--+++-++
-+++++
+-+--+
+----+++-++
-+-+++-++-+
+---++
+----+
+-+---++?++
++++-+
++-+-+
-+++++
++++-+
--++-+
----++
-----+
++-+++
-----+-+--++++-+
--+---+-+++
++-+-+
+++++-----++++++
-+----++--+
--+-++
+-+--+
-+++-+
++++-+
+++-++
--++------++++-+
+-+-----+-++---+
--++++
---+-+
---------+++-+-+
--+---+++++
+--+++-++++
+--+++
+-++-+
+-+-+++-+++
+++++---+----+--
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.937
1.937
1.937
1.937
-1.937
-1.937
-1.936
1.936
1.936
-1.935
-1.935
-1.935
1.935
-1.935
1.933
-1.933
-1.933
-1.932
-1.931
-1.931
1.931
1.931
-1.931
-1.93
1.929
-1.928
-1.928
1.927
1.927
1.927
1.926
-1.926
1.925
1.924
1.924
1.923
1.922
1.922
1.922
1.921
1.921
1.921
1.921
1.918
1.918
1.918
-1.917
-1.917
-1.917
1.917
1.917
1.916
-1.916
1.915
-1.915
-1.915
-1.914
1.913
-1.913
1.913
1.912
1.912
-1.911
1.91
-1.91
-1.91
-1.909
-1.909
-1.909
1.909
-1.908
-1.908
1.908
-1.907
-1.907
-1.907
1.907
-1.906
1.906
-1.905
1.904
-1.904
1.904
1.903
1.903
-1.902
1.902
1.9
-1.9
-1.9
1.899
1.899
-1.899
1.897
1.897
1.897
-1.897
1.897
-1.896
1.896
1.895
-1.895
-1.895
1.895
1.894
1.893
1.892
1.892
1.892
-1.891
-1.891
1.891
-1.89
-1.89
1.889
-1.889
1.888
1.887
1.887
-1.887
1.886
-1.886
1.885
1.885
1.884
1.884
1.884
1.883
-1.883
-1.882
1.882
-1.882
-1.882
1.881
1.881
-1.881
-1.881
-1.88
1.88
-1.88
1.879
-1.879
1.879
1.877
1.877
1.877
1.876
1.876
-1.876
-1.875
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
5.28E-02
5.28E-02
5.28E-02
5.28E-02
5.28E-02
5.28E-02
5.28E-02
5.29E-02
5.29E-02
5.30E-02
5.30E-02
5.30E-02
5.30E-02
5.30E-02
5.32E-02
5.33E-02
5.33E-02
5.33E-02
5.34E-02
5.34E-02
5.35E-02
5.35E-02
5.35E-02
5.37E-02
5.37E-02
5.38E-02
5.39E-02
5.39E-02
5.40E-02
5.40E-02
5.41E-02
5.41E-02
5.42E-02
5.43E-02
5.44E-02
5.45E-02
5.46E-02
5.46E-02
5.46E-02
5.47E-02
5.48E-02
5.48E-02
5.48E-02
5.51E-02
5.51E-02
5.51E-02
5.52E-02
5.52E-02
5.52E-02
5.52E-02
5.53E-02
5.53E-02
5.53E-02
5.54E-02
5.55E-02
5.55E-02
5.57E-02
5.57E-02
5.57E-02
5.58E-02
5.59E-02
5.59E-02
5.60E-02
5.61E-02
5.62E-02
5.62E-02
5.62E-02
5.62E-02
5.63E-02
5.63E-02
5.64E-02
5.64E-02
5.64E-02
5.65E-02
5.65E-02
5.65E-02
5.66E-02
5.66E-02
5.67E-02
5.68E-02
5.69E-02
5.69E-02
5.69E-02
5.70E-02
5.70E-02
5.71E-02
5.72E-02
5.74E-02
5.74E-02
5.75E-02
5.75E-02
5.76E-02
5.76E-02
5.78E-02
5.78E-02
5.78E-02
5.78E-02
5.79E-02
5.79E-02
5.80E-02
5.80E-02
5.80E-02
5.81E-02
5.81E-02
5.82E-02
5.83E-02
5.85E-02
5.85E-02
5.85E-02
5.86E-02
5.87E-02
5.87E-02
5.87E-02
5.87E-02
5.89E-02
5.89E-02
5.90E-02
5.92E-02
5.92E-02
5.92E-02
5.93E-02
5.94E-02
5.94E-02
5.95E-02
5.96E-02
5.96E-02
5.96E-02
5.97E-02
5.97E-02
5.98E-02
5.98E-02
5.99E-02
5.99E-02
5.99E-02
5.99E-02
6.00E-02
6.00E-02
6.01E-02
6.01E-02
6.01E-02
6.02E-02
6.02E-02
6.03E-02
6.05E-02
6.06E-02
6.06E-02
6.06E-02
6.06E-02
6.07E-02
6.08E-02
62479
19581
36237
3823
17130
30043
62812
50780
23356
48959
64491
27626
48623
15967
43017
48392
13456
39511
67801
64198
19753
32424
39474
60533
35466
56645
39128
48033
10972
19800
1490
35444
12380
41253
44289
33118
8661
24355
64450
25019
40068
35146
17072
42678
38327
30624
49158
68041
14000
66454
27320
46485
4461
59106
22471
50034
31077
33701
67308
16095
5522
31825
26508
47320
68006
58882
26272
52820
27524
57428
4303
20177
3091
6573
23509
32206
6179
47436
42733
66259
61627
57874
68473
9979
44975
23095
56817
5151
53205
45218
37923
41158
55778
13569
18077
58704
29055
49184
1448
37079
63729
16607
22020
10491
37166
34940
60636
3734
44296
50354
51449
65222
40558
61717
38885
47704
3855
33870
30123
33001
42090
40529
40271
64675
16775
19351
40471
65231
19963
28581
4575
19501
55449
39407
40066
46762
64279
2736
37811
21113
34181
67769
34250
2932
12913
56004
50018
29595
38437
10466
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
7444
65977
602
8576
116840
341032
122402
7965
115557
7784
93487
529
546
23473
57154
112616
83541
26058
9761
26
3799
27097
5562
29928
56943
8634
1646
84271
100129828
84315
9696
51002
23327
8681
81629
146542
3352
23531
55139
84807
26149
79027
57461
157378
57596
8812
159
3214
55008
56666
2193
10627
4763
54707
9991
3841
54566
124936
6703
55010
7074
192286
220074
79092
8888
127707
3661
219771
27112
83593
196513
30850
55902
51072
159296
51478
63906
9475
6675
3305
57455
146223
441151
23154
55341
84256
22919
54842
1960
388799
6768
22821
23171
5424
64710
57186
283537
55810
5926
4253
54870
27239
8379
51307
51493
6950
1687
146177
3487
158747
25972
116842
23362
124540
89845
26051
4946
63978
6016
140886
84645
54948
128344
161253
229
10568
10460
10124
7841
29974
63970
9988
7551
5091
57645
161176
523
3660
55657
23038
8301
10964
142678
84336
84923
80775
55652
23166
6872
90580
VRK2
PLEKHA3
BCL3
STK16
CNTROB
C11orf53
TDRD9
AIMP2
ARHGEF25
ZP3
MAPK1IP1L
ATP6V1E1
ATRX
CAPN7
SMURF1
CMTM7
FAM110A
GIGYF2
MLEC
AOC1
KIF5B
TAF5L
PRKAA1
TIMM22
ENY2
RTCA
AKR1C2
POLDIP3
MGC50273
MON1A
CROCC
TPRKB
NEDD4L
JMJD7-PLA2G4B
TSSK3
ZNF688
HTR1D
MMD
ANKZF1
NFKBID
ZNF658
ZNF655
ISY1
TMEM65
BEGAIN
CCNK
ADSS
HOXB4
HERC6
PANX2
FARSA
MYL12A
NF1
GPN2
PTBP3
KPNA5
EPB41L4B
CYB5D2
SPRR2D
PARPBP
TIAM1
HIGD2A
LRTOMT
CARD14
MCM3AP
KLHDC7A
IRF3
CCNY
FAM155B
RASSF5
DCP1B
CDR2L
ACSS2
MEMO1
NKX2-3
HSD17B7
GPATCH3
ROCK2
UAP1
HSPA1L
REXO1
CMTM4
TMEM151B
NCDN
LSG1
FLYWCH1
MAPRE1
MFSD6
EGR3
FAM209B
ST14
RASA3
GPD1L
POLD1
NUCKS1
RALGAPA2
SLC46A3
FOXJ2
ARID4A
CTAGE5
QRICH1
GPR162
MAD1L1
FAM53C
RTCB
TCP1
DFNA5
VWA3A
IGFBP4
MOSPD2
UNC50
LEAP2
PSD3
MSI2
ABCC10
PPP1R16B
OAZ1
PRDM14
RIT1
PABPC5
C22orf23
MRPL16
PIFO
REM2
ALDOB
SLC34A2
TACC3
ARL4A
MOGS
A1CF
TP53AIP1
DMTF1
ZNF3
PC
POGK
SYNE3
ATP6V1A
IRF2
ZNF692
WDTC1
PICALM
IFI44L
MIB2
TMEM101
FAM104A
TMEM177
SLC48A1
STAB1
TAF1
C19orf52
+-++-+
---+++++--+
+-++++
++-+++
-++-++
--+--+
---+-+
-+-+++
+++-++
+----+++-++
-+-+----+-+----+
---+-+
--+-+-+-+--+---+
++--++
+-+-------+
+-+?------+
+-++-+
--++++
+---+-----+
+++-++
----++
++----+-+++--+-+----+
--++++
+--+-+
-++?++
+-+-+++-+++
-+-?++
--++-+
+++-+-+++++
+-+--++-+++
+------+?-+
++-+++
+----+-++-+
-----+
+--+-+++--+
----++
+-+--++--+--++++
+--+++
+-+-++-++-+--+----+-+
+-++++
++-+-+
-+--++
+-++-+
++-++++++-+
-++-++
++++-+
+----+-++-+
--++-+
+-+++-+--++
--+?-++-+-+
++++-+-++-+
+-++-+
++--++
--++-+
-+-+++
++-?-+
-----+
++--++
+-++-+
+--?++
++++++-+-++
--+--+
+---++---+-----+
--+---+++-+
-+--+----+--+--++-++-----+
--+-+-+---+
+++-++
-----+
--+?-+
-----+
--++++
++-+-+
+-+----++-+
+-----+++++
++-++++-+++
++-+-+
++-++++-+++
+-++-+
++++++
+++--+
--++-++-+++
+++--+
++-+-+
+++-++
+-+--+
++++--+-+-+
+-+-++
++-+++
+-------+-+
+++--+
---?-+
--+?++
--+--+
+++-++
-+-+++
-+++-+
+-+---+++-+
-+---+
---+-+
+++++-+-++++-++--+--+
-+-+----+-+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.874
-1.874
1.874
1.874
1.873
1.873
-1.872
-1.872
1.872
1.872
-1.871
1.87
-1.87
-1.87
1.867
-1.867
-1.867
-1.865
-1.864
1.862
-1.862
1.862
-1.861
-1.861
1.861
1.861
-1.86
-1.859
1.859
1.859
-1.858
-1.858
-1.858
-1.858
1.857
1.856
1.855
-1.855
1.855
1.854
1.854
1.854
1.854
-1.854
1.853
-1.853
-1.852
1.852
-1.851
1.851
-1.851
-1.85
1.85
1.85
-1.849
-1.849
1.849
1.848
1.848
-1.848
-1.847
-1.847
1.846
1.846
-1.845
1.845
1.845
1.844
1.844
1.844
-1.843
1.843
1.842
1.842
1.842
-1.842
1.841
1.84
1.84
1.84
1.84
1.84
1.84
1.84
-1.838
1.837
1.837
1.836
1.836
1.836
1.834
-1.834
-1.833
-1.833
-1.833
1.832
-1.831
-1.831
-1.831
1.831
-1.831
-1.83
-1.83
1.829
-1.829
-1.829
-1.829
1.829
1.829
-1.827
-1.826
-1.826
1.826
1.826
1.825
1.825
1.825
1.825
1.825
1.824
1.824
-1.824
1.823
1.823
1.822
1.822
-1.822
-1.822
-1.822
1.822
1.821
-1.821
-1.82
1.819
-1.818
1.818
-1.818
1.818
1.818
1.818
-1.817
1.817
-1.817
-1.816
1.816
-1.816
1.815
1.814
-1.814
-1.813
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
6.09E-02
6.09E-02
6.10E-02
6.10E-02
6.11E-02
6.11E-02
6.11E-02
6.12E-02
6.13E-02
6.13E-02
6.14E-02
6.14E-02
6.15E-02
6.15E-02
6.19E-02
6.19E-02
6.20E-02
6.22E-02
6.23E-02
6.26E-02
6.26E-02
6.26E-02
6.28E-02
6.28E-02
6.28E-02
6.28E-02
6.29E-02
6.30E-02
6.30E-02
6.31E-02
6.31E-02
6.31E-02
6.32E-02
6.32E-02
6.33E-02
6.35E-02
6.36E-02
6.36E-02
6.36E-02
6.37E-02
6.37E-02
6.37E-02
6.38E-02
6.38E-02
6.39E-02
6.39E-02
6.40E-02
6.41E-02
6.41E-02
6.42E-02
6.42E-02
6.43E-02
6.43E-02
6.44E-02
6.45E-02
6.45E-02
6.45E-02
6.45E-02
6.45E-02
6.46E-02
6.47E-02
6.47E-02
6.49E-02
6.49E-02
6.50E-02
6.50E-02
6.51E-02
6.52E-02
6.52E-02
6.52E-02
6.53E-02
6.53E-02
6.54E-02
6.54E-02
6.55E-02
6.55E-02
6.56E-02
6.57E-02
6.58E-02
6.58E-02
6.58E-02
6.58E-02
6.58E-02
6.58E-02
6.61E-02
6.62E-02
6.62E-02
6.64E-02
6.64E-02
6.64E-02
6.66E-02
6.66E-02
6.67E-02
6.68E-02
6.69E-02
6.70E-02
6.70E-02
6.70E-02
6.71E-02
6.71E-02
6.72E-02
6.73E-02
6.73E-02
6.74E-02
6.74E-02
6.74E-02
6.74E-02
6.75E-02
6.75E-02
6.77E-02
6.78E-02
6.78E-02
6.79E-02
6.79E-02
6.80E-02
6.80E-02
6.80E-02
6.80E-02
6.81E-02
6.81E-02
6.81E-02
6.82E-02
6.82E-02
6.83E-02
6.84E-02
6.84E-02
6.84E-02
6.85E-02
6.85E-02
6.85E-02
6.85E-02
6.87E-02
6.88E-02
6.89E-02
6.90E-02
6.90E-02
6.90E-02
6.91E-02
6.91E-02
6.91E-02
6.92E-02
6.92E-02
6.92E-02
6.93E-02
6.94E-02
6.94E-02
6.96E-02
6.97E-02
6.97E-02
6.98E-02
41425
4327
3140
35268
8229
47309
22796
37195
15647
59067
38788
60316
64997
7520
44320
49077
11683
66604
11496
42933
18150
11134
34602
25849
40400
27713
41773
57530
29035
54060
29514
43833
43801
8255
25638
43938
53799
26948
38184
49768
65226
24356
14349
23979
65338
50236
4403
26158
14618
18920
46947
27861
19236
41959
20994
33275
17088
29457
51983
3444
12658
1737
16561
43260
46244
14502
64407
16599
56060
3325
38591
24040
65081
9931
14098
39091
6919
16112
40091
7183
41810
3225
46151
44752
10547
47634
9689
47560
31313
55992
40655
14423
18073
39260
1477
60792
36799
49319
17635
67919
11040
19999
55097
33360
19345
56923
45672
58046
46343
55725
41184
18545
30661
48174
1194
274
34387
41949
33398
7540
44391
49982
26167
21430
6224
35158
12829
45451
45559
30569
1621
8779
35313
40748
49686
42600
46846
7817
61291
19716
46533
38994
39947
17420
10520
33824
38669
67617
65324
50548
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
3421
54941
3692
7101
81857
482
79974
22797
54499
3425
57190
252983
89890
3006
51185
53944
23185
1303
159090
2820
7922
51074
374900
51143
57095
23567
79594
114900
9213
11264
23564
4878
5272
2049
4837
9700
58526
81875
83642
374462
28990
391189
150372
8618
148870
10139
9767
6698
26985
118987
9337
9530
55679
84193
10069
51750
84187
4833
55825
5063
85013
337959
572
7385
11066
51
10462
286006
1716
116328
51022
1660
3109
55193
11262
54708
1385
201299
5003
131920
25809
10350
200014
55633
3665
54491
25963
150365
23589
23513
9584
285800
84164
10613
3580
23193
641649
144453
80006
51643
2646
4154
124935
54878
29943
6745
222194
57693
114826
23390
55206
8565
5978
3268
5682
84217
10147
29126
23648
163033
26750
201931
9628
249
25913
3757
7918
390054
55450
63917
51274
5910
79078
1059
151295
79807
51164
5993
5613
4534
113655
1635
197322
9320
3172
55544
55051
29935
56969
51258
IDH3G
RNF125
EIF6
NR2E1
MED25
ATP1B2
CPED1
TFEC
TMCO1
IDUA
SEPN1
STXBP4
KBTBD6
HIST1H1C
CRBN
CSNK1G1
LARP4B
COL12A1
FAM122B
GPD2
SLC39A7
APIP
ZNF568
DYNC1LI1
PITHD1
ZNF346
MUL1
C1QTNF4
XPR1
PXMP4
DDAH2
NPPA
SERPINB9
EPHB3
NNMT
ESPL1
MID1IP1
ISG20L2
RP3-402G11.5
PTPRQ
ASTE1
OR11L1
NFAM1
CADPS
CCDC27
ARFRP1
PHF16
SPRR1A
AP3M1
PDZD8
CNOT8
BAG4
LIMS2
SETD3
RWDD2B
RTEL1
TMEM164
NME4
PECR
PAK3
TMEM128
KRTAP13-2
BAD
UQCRC2
SNRNP35
ACOX1
CLEC10A
LSMEM1
DGUOK
C8orf34
GLRX2
DHX9
HLA-DMB
PBRM1
SP140
MARCH5
CREB1
RDM1
SLC22A18AS
TMEM207
TTLL1
ABCA9
CC2D1B
TBC1D22B
IRF7
FAM105A
TMEM87A
MEI1
CARHSP1
SCRIB
RBM39
PRR18
ASCC2
ERLIN1
CXCR2P1
GANAB
TMEM91
BEST3
TRAPPC13
TMBIM4
GCKR
MBNL1
SLC43A2
DPP8
PADI1
SSR1
RSBN1L
ZNF317
SMYD4
ZDHHC17
SBNO1
YARS
REST
AGFG2
PSMA1
ZMYND12
SUGP2
CD274
SSBP3
ZNF579
RPS6KC1
TMEM192
RGS6
ALPL
POT1
KCNH2
GPANK1
OR52A5
CAMK2N1
GALNT11
KLF3
RAP1GDS1
C1orf50
CENPB
SLC23A3
GSTCD
DCTN4
RFX5
PRKX
MTM1
MFSD3
DCTD
ACSF3
TRIP12
HNF4A
RBM38
NRDE2
RPA4
AC092839.1
MRPL51
-+-+-+
+-++++
-+---+
++-+-+
+++++-+-+---+--+
+-+--+
+-++++
-+---+
++++-+--+--+-+---++-+
+--++++--++
++---+
-+++++
+----+
+-+-++
-+++-+
---+++
+--++++++-+
++-++-----+-++-+
++-?++
+-+-++
-----+
---+++
-++-++
++-+++
++--++
+-+?-+
++++-+
++++-+
-+++-+
++++-+
++++-+
---+-++++-+
--+--+
++-?++
++++-+
-----+
---+-+
++-+++
-----+
+-+--+
--+--+
-++?-+
-----+
---+-----+++-+++
++++++
-+-++---+--+-+++
-----+--+++
++-+++
--++-++++++
-+++-+
+-++++
+-++----+-+
-+++++
+-++-+
-+-+---++-+
-----++-+++
+--------+---+--++?-+
++++-+
----++
--+--+
++-?++
++-++-+++-+
--++-+
+---++
++-+++
-+++++
++-+++
-+---+-++++
++-++--++-+
++--+-+---++++-+
-++++--+--+-++-+
++++++
+-+--++++-+
++-+++--+++
--++-+
--+-----+-+
-----+
+-+--+-++----?-+
+--+-++---+
---+-+--+-++-+++
+-+++++-++-----+-++++
-----+
+--+++-+?+--+++-+-+++
+--+-+
-+---++--++
-+-+-+
-+++-++-+++
---+--+-+++
-----+
--+-++-++-+
+--+++
+--?---+-------+
---+-+
--+--+
+-+++---+++
++-++++---+
--++-+
-----+
---+-+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.812
1.812
1.812
1.812
1.812
-1.812
-1.811
1.811
1.811
-1.811
1.81
-1.81
-1.81
1.81
-1.81
1.809
1.809
1.808
-1.808
1.807
1.807
-1.807
-1.807
1.806
1.806
-1.805
1.804
1.804
1.804
-1.803
1.803
1.803
1.802
1.802
1.802
1.802
1.802
1.801
1.801
1.801
-1.8
1.799
1.799
1.798
1.798
-1.797
-1.797
1.797
-1.796
1.795
1.795
1.795
-1.795
-1.794
-1.794
1.794
1.793
-1.792
-1.792
1.792
-1.791
1.791
1.79
-1.79
1.789
1.788
1.788
1.787
-1.786
1.786
1.786
-1.786
1.785
-1.784
1.784
-1.784
-1.784
-1.784
1.783
1.783
-1.782
1.781
1.781
1.781
1.781
1.781
-1.78
1.78
1.78
1.779
-1.777
1.777
-1.777
1.776
1.776
-1.775
1.775
1.775
-1.775
1.775
1.775
-1.774
1.774
1.774
1.773
-1.772
-1.772
-1.772
-1.771
-1.77
-1.77
-1.77
-1.769
1.769
-1.769
-1.768
1.768
1.768
1.768
-1.768
1.768
-1.767
-1.767
-1.767
-1.767
1.766
1.766
-1.766
1.764
1.764
-1.764
1.764
-1.763
1.763
-1.763
-1.762
1.762
1.762
-1.761
-1.76
-1.76
-1.76
-1.759
1.759
1.757
1.757
1.757
1.756
-1.755
-1.755
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
6.99E-02
7.00E-02
7.00E-02
7.00E-02
7.01E-02
7.01E-02
7.01E-02
7.02E-02
7.02E-02
7.02E-02
7.02E-02
7.03E-02
7.03E-02
7.03E-02
7.04E-02
7.04E-02
7.05E-02
7.06E-02
7.07E-02
7.07E-02
7.07E-02
7.07E-02
7.08E-02
7.09E-02
7.10E-02
7.11E-02
7.12E-02
7.13E-02
7.13E-02
7.14E-02
7.14E-02
7.14E-02
7.15E-02
7.15E-02
7.16E-02
7.16E-02
7.16E-02
7.16E-02
7.16E-02
7.18E-02
7.19E-02
7.20E-02
7.21E-02
7.22E-02
7.23E-02
7.23E-02
7.23E-02
7.24E-02
7.25E-02
7.26E-02
7.26E-02
7.27E-02
7.27E-02
7.27E-02
7.28E-02
7.28E-02
7.29E-02
7.31E-02
7.31E-02
7.32E-02
7.32E-02
7.33E-02
7.35E-02
7.35E-02
7.37E-02
7.37E-02
7.38E-02
7.40E-02
7.41E-02
7.41E-02
7.41E-02
7.42E-02
7.43E-02
7.44E-02
7.44E-02
7.44E-02
7.44E-02
7.44E-02
7.45E-02
7.47E-02
7.47E-02
7.49E-02
7.49E-02
7.49E-02
7.49E-02
7.50E-02
7.50E-02
7.51E-02
7.51E-02
7.53E-02
7.56E-02
7.56E-02
7.56E-02
7.57E-02
7.58E-02
7.59E-02
7.59E-02
7.59E-02
7.59E-02
7.60E-02
7.60E-02
7.60E-02
7.61E-02
7.61E-02
7.63E-02
7.64E-02
7.64E-02
7.65E-02
7.66E-02
7.67E-02
7.68E-02
7.68E-02
7.68E-02
7.69E-02
7.69E-02
7.70E-02
7.70E-02
7.71E-02
7.71E-02
7.71E-02
7.71E-02
7.72E-02
7.72E-02
7.73E-02
7.73E-02
7.73E-02
7.74E-02
7.74E-02
7.77E-02
7.78E-02
7.78E-02
7.78E-02
7.78E-02
7.80E-02
7.80E-02
7.81E-02
7.81E-02
7.81E-02
7.82E-02
7.84E-02
7.84E-02
7.85E-02
7.85E-02
7.86E-02
7.89E-02
7.89E-02
7.89E-02
7.90E-02
7.93E-02
7.93E-02
54157
28951
52464
18336
15568
67076
37101
20256
27671
61437
58484
27229
28003
40204
50538
56226
957
10118
15455
37130
42025
27038
13374
63418
57118
45335
26541
27400
60392
61966
10081
4748
50126
54679
13495
27424
46847
11629
16610
52761
67891
9915
38651
43567
60625
10634
12741
21828
67513
29999
33044
66240
50199
12710
1296
67704
46908
14719
45193
34327
52902
3386
45316
38646
28783
5136
34683
12369
24066
61680
63705
63707
26408
63883
33731
6586
64167
58228
50288
45436
16155
8642
46712
37394
67356
59802
30495
26342
58084
18809
5607
51037
11793
25742
57690
41656
11895
38938
67205
28870
8560
20096
24042
9153
9489
53916
7164
62001
41868
21905
11823
33076
50737
25315
22929
30435
66417
7301
51184
46970
68352
46573
46165
8544
19703
25405
12005
5109
48229
37438
48838
24413
43095
47948
54470
37786
46152
28213
50622
36623
16589
58058
33598
45956
32456
8279
66267
8098
16962
56149
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
6261
9374
91252
201176
7454
79025
22826
54542
138881
843
2686
4485
3770
27152
4745
5919
10509
252969
390066
10186
51652
28974
8703
166979
6696
26502
51374
79616
22904
84233
2109
1877
9611
377677
84068
493861
2247
64326
25984
25853
51733
55032
84222
10668
22897
8036
23256
11235
7979
400451
169792
5966
55298
254428
431705
142679
92285
23168
54495
1018
57140
10512
83637
55904
79783
134265
23550
56899
387750
79890
91304
6309
9295
344892
55322
5082
5101
253943
22915
54933
440107
4542
29071
3720
340441
10744
5292
100129828
132989
5143
23093
5155
587
79173
64802
9563
55676
25874
325
10209
155435
7401
3845
389084
9604
54681
9814
9590
57708
58508
4179
4690
960
51271
84276
1663
10457
91748
669
283521
8427
146760
2877
51496
54862
7773
5728
3953
4791
126119
54923
23070
995
4174
51617
6120
10388
57446
57096
254359
10876
6888
652968
83541
116151
51642
57605
80350
55198
54386
RYR1
PPT2
SLC39A13
ARHGAP27
WAS
C20orf195
DNAJC8
RC3H2
OR1L8
CASP10
GGT7
MST1
KCNJ14
INTU
NELL1
RARRES2
SEMA4B
NEIL2
OR52D1
LHFP
CHMP3
C19orf53
B4GALT3
CDC20B
SPP1
NARF
ATRAID
CCNJL
SBNO2
TMEM126A
ETFB
E4F1
NCOR1
CA13
SLC10A7
EID3
FGF2
RFWD2
KRT23
DCAF12
UPB1
SLC35A5
TMEM191A
CGRRF1
CEP164
SHOC2
SCFD1
PDCD10
SHFM1
FAM174B
GLIS3
REL
RNF121
SLC41A1
ASTL
DUSP19
ZNF585B
RTF1
TMX3
CDK3
RNPEPL1
SEMA3C
ZMIZ2
KMT2E
C7orf10
AFAP1L1
PSD4
ANKS1B
CCDC35
RIN3
TMEM259
SC5D
SRSF11
RTP2
C5orf22
PDCL
PCDH9
YTHDF3
MMRN1
RHBDL2
PLEKHG7
MYO1F
C1GALT1C1
JARID2
POTEA
PTTG2
PIM1
C17orf54
C4orf36
PDE4C
TTLL5
PDGFB
BCAT2
C19orf57
NMNAT1
H6PD
SLC30A6
MPC2
APCS
EIF1
RBM33
CLRN1
KRAS
C2orf82
RNF14
P4HTM
SFI1
AKAP12
MIER1
KMT2C
CD46
NCK1
CD44
UBAP1
NICN1
DDX11
GPNMB
ELMSAN1
BPGM
FLJ37307
ZNF282
RTN4RL1
GPX2
CTDSPL2
CC2D1A
ZNF230
PTEN
LEPR
NFKB2
JOSD2
LIME1
FTSJD2
CDC25C
MCM5
NSG2
RPE
SYCP2
NDRG3
RPGRIP1
ZDHHC24
EDDM3A
TALDO1
GATSL3
FAM110A
FAM210B
MRPL48
PITPNM2
LPAL2
APPL2
TERF2IP
+-+--+
-++--+
-+++-+
+++-+++++-+
++-+++
---+-+
+--++-++--+
--++++
---+-+
-+-+-+-+-++
----+--+-++
++-+++
+++--+
---+++
+++++++++-+
+++++---+-+
++-?++
+++-++
+++-++
+++-++
-+-+++
+-+--+++--+
---++-----+
-----+
++---++++++--+++
---+-+
+-++++
++++-+
-++--+++++--+--+
+-+--+
-+---+-+?+++-+++
+-++---+-+--+?+-----+
--++-+
+++--+
++++-+
-+++++
---+-+
++++-+
+++---+--+++-+++-+--++-+++
-+-+-+
+-+--+
++--++
+-++--+-+-++++++
++---+
+++-++
---++-+++-+
-----+
+--+++-+--++---+
--+---++---++--+-+--+
+++++++----+-+++
+++--+
+-++---+--+
-++----+--++-++++--+++++++
+++--+
+-++-++--++
-+-?-+
-+--++
-+++-+
+---++
--+--+++++++-+++
-+-+-+-+--+
++++-+++++++-+-+
+-+++++--++
--+--+
+-++---++-+-+--+
+-+--+
--+--+
+-++-+
+++++---+-+
--+---+++++
+-+--+
++-++---+-+
++-?-+
++++++
++-+++
--+++-+--++
+-+-++
+-+--++-?-+-+--+
--++-+
-----+
+++--+
+++?++
-+--++
-+++++
--++-++++-+
++-+-+
--++-+
++++-+
++-+++
++++--+++++
+---++++++--++--++++---+++
--+--+
--+---
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.754
-1.754
1.754
1.754
1.754
1.753
-1.753
1.753
1.753
1.752
-1.752
-1.751
1.751
-1.749
1.748
1.748
1.748
-1.748
1.748
1.747
1.747
-1.746
1.746
1.746
1.746
1.745
1.745
-1.745
1.743
-1.743
-1.743
-1.743
-1.743
1.742
1.742
-1.741
1.741
1.741
-1.741
1.741
-1.741
1.74
-1.74
1.74
1.739
-1.739
-1.739
-1.738
-1.739
-1.738
1.737
1.737
1.737
-1.735
1.735
-1.734
-1.734
1.734
-1.733
1.733
1.731
1.731
1.731
-1.731
-1.73
1.73
1.73
1.729
-1.729
1.729
-1.729
-1.728
-1.727
1.727
-1.727
-1.726
-1.726
1.725
1.725
-1.725
1.725
1.725
-1.724
-1.724
-1.722
-1.721
1.721
1.721
1.721
1.72
-1.72
1.72
-1.72
1.719
1.719
1.719
-1.718
1.717
1.717
-1.717
-1.716
1.716
1.715
1.715
-1.714
1.714
-1.713
-1.713
-1.713
1.712
1.711
-1.711
1.711
1.71
1.71
-1.71
1.71
-1.709
-1.709
-1.709
1.709
1.708
1.708
-1.708
1.708
1.707
-1.707
-1.707
-1.707
1.707
-1.706
1.705
1.705
1.705
1.705
-1.704
1.704
1.704
-1.704
1.704
1.703
1.703
1.702
-1.702
1.701
-1.701
1.701
1.701
-1.701
-1.701
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
7.94E-02
7.94E-02
7.94E-02
7.94E-02
7.94E-02
7.96E-02
7.96E-02
7.97E-02
7.97E-02
7.97E-02
7.98E-02
8.00E-02
8.00E-02
8.03E-02
8.04E-02
8.05E-02
8.05E-02
8.05E-02
8.05E-02
8.06E-02
8.06E-02
8.08E-02
8.08E-02
8.08E-02
8.09E-02
8.09E-02
8.10E-02
8.10E-02
8.13E-02
8.13E-02
8.13E-02
8.14E-02
8.14E-02
8.15E-02
8.15E-02
8.16E-02
8.16E-02
8.17E-02
8.17E-02
8.18E-02
8.18E-02
8.18E-02
8.18E-02
8.18E-02
8.20E-02
8.20E-02
8.21E-02
8.21E-02
8.21E-02
8.23E-02
8.23E-02
8.24E-02
8.25E-02
8.27E-02
8.28E-02
8.29E-02
8.29E-02
8.30E-02
8.30E-02
8.31E-02
8.34E-02
8.34E-02
8.35E-02
8.35E-02
8.36E-02
8.36E-02
8.37E-02
8.38E-02
8.38E-02
8.39E-02
8.39E-02
8.40E-02
8.41E-02
8.42E-02
8.42E-02
8.44E-02
8.44E-02
8.45E-02
8.45E-02
8.45E-02
8.46E-02
8.46E-02
8.47E-02
8.48E-02
8.51E-02
8.52E-02
8.52E-02
8.53E-02
8.53E-02
8.54E-02
8.54E-02
8.54E-02
8.54E-02
8.56E-02
8.56E-02
8.57E-02
8.59E-02
8.59E-02
8.60E-02
8.61E-02
8.62E-02
8.62E-02
8.63E-02
8.64E-02
8.65E-02
8.65E-02
8.67E-02
8.68E-02
8.68E-02
8.69E-02
8.70E-02
8.70E-02
8.71E-02
8.73E-02
8.73E-02
8.73E-02
8.73E-02
8.74E-02
8.74E-02
8.74E-02
8.75E-02
8.76E-02
8.77E-02
8.77E-02
8.77E-02
8.77E-02
8.78E-02
8.78E-02
8.78E-02
8.79E-02
8.81E-02
8.82E-02
8.83E-02
8.83E-02
8.83E-02
8.83E-02
8.83E-02
8.84E-02
8.84E-02
8.85E-02
8.85E-02
8.85E-02
8.87E-02
8.88E-02
8.89E-02
8.89E-02
8.89E-02
8.90E-02
8.90E-02
8.90E-02
4591
2930
55485
57977
13234
5670
59446
51457
58402
18978
18500
64078
42294
36670
40943
8670
23076
7960
16863
32493
65506
3404
33050
61869
62923
53236
20289
31350
2978
50642
725
38675
27916
27246
37221
61780
64196
41042
46231
21135
17743
11761
15761
29778
755
47464
654
53699
27427
3956
19966
2545
513
59827
16375
36463
33643
17021
55358
53829
21289
65574
12175
28119
58859
68129
46920
21337
21793
8354
14112
35861
5742
27792
18627
34154
47683
45066
12953
48274
28429
42570
36297
42549
18378
28728
33817
66945
17205
32688
46566
63630
66913
43496
7956
32027
1499
50948
53895
1367
39192
7238
47812
56282
33483
53759
22908
11858
62868
11842
28760
32099
29225
10195
35719
48941
49666
64338
24113
18191
43515
24842
67675
26659
35595
51693
4605
55235
61993
13531
17726
36798
60317
36356
37387
2228
38992
64193
20057
47881
32280
19741
5260
17798
47047
68084
31930
35512
61142
1989
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
3104
283459
23536
29088
60437
54963
85437
7737
90416
25888
140597
1456
116337
23467
4851
23774
3726
100129828
996
84808
54825
83636
9796
30010
1995
9989
27333
9025
23085
8208
5893
6683
92140
5216
55776
10082
23516
200186
8548
7430
84844
11212
56648
203286
64115
54437
119392
219954
55763
126074
80152
55093
6541
6502
81853
93185
50626
55698
65993
5524
6185
57664
3948
126789
200845
127933
22914
23111
554223
8455
168374
27094
205327
8648
26090
58529
8343
64121
6878
4599
10983
65243
4515
1477
5036
51260
84678
7442
153684
54726
25917
2803
4249
132160
9501
162989
140467
79573
9854
11040
57129
3198
127670
284161
4123
65990
9267
55930
100129828
79366
88
65080
7145
3957
10989
25852
145258
66036
4616
10990
221908
339479
285704
64789
8852
81617
26259
2071
1738
23114
5530
92170
51582
54916
81341
3897
55777
2885
54550
23008
63930
4724
55343
27107
132321
54891
6760
50853
284618
9889
ZBTB48
GATC
ADAT1
MRPL15
CDH26
UCKL1
ZCRB1
RNF113A
C15orf57
ZNF473
TCEAL2
CSNK1G3
PANX3
NPTXR
NOTCH1
BRD1
JUNB
HSPBP1
CDC27
C1orf170
CDHR2
C19orf12
PHYHIP
NXPH1
ELAVL3
PPP4R1
GOLIM4
RNF8
ERC1
CHAF1B
RAD52
SPAST
MTDH
PFN1
SAYSD1
GPC6
SLC39A14
CRTC2
BLZF1
EZR
PHF5A
PROSC
EIF5A2
ANKS6
C10orf54
SEMA5B
SFR1
OR9I1
EXOC1
SWSAP1
CENPT
WDYHV1
SLC7A1
SKP2
TMEM14B
IGSF8
CYHR1
RADIL
MRPS34
PPP2R4
RPN2
PLEKHA4
LDHC
PUSL1
KCTD6
UHMK1
KLRK1
SPG20
LOC554223
ATRN
ZNF92
KCNMB3
C2orf69
NCOA1
ABHD12
MYOZ1
HIST1H2BF
RRAGC
TAF6
MX1
CCNI
ZFP69B
MTCP1
CSTF1
PA2G4
PBDC1
KDM2B
TRPV1
LOC153684
OTUD4
THUMPD3
GOLGA4
MGAT5
PPM1M
RPH3AL
DEDD2
ZNF358
TTC13
C2CD2L
PIM2
MRPL47
HOXA1
TEDDM1
GDPD1
MAN2C1
FAM173A
CYTH1
MYO5C
CS
HMGN5
ACTN2
MRPL44
TNS1
LGALS2
IMMT
ARMC8
GSC
MTMR9
GADD45B
LILRB5
PPP1R35
FAM5C
RGMB
EXO5
AKAP4
CAB39L
FBXW8
ERCC3
DLD
NFASC
PPP3CA
MTG1
AZIN1
TMEM260
OR10W1
L1CAM
MBD5
GRB2
NECAB2
KLHDC10
RP11-305P22.9
NDUFS4
SLC35C1
ZBTB11
C4orf33
INO80D
SS18
VILL
C1orf104
ZBED4
+++--+
----+-++-++
+-++-+
--++++
-----+
--++------+
---+-+
++++-+
+---+--+-+++--++
++++++
+-+-------+
+++-++--+++
+++-++-++++
+++-++
-+---+
+---++
++--++
+++--+
+-+-++-++++
---------+-+++++
----++-+--+
--+--+
++-?-+
-----+
++-+++
---+-+-+--+
+++--++--++
-----+
--++-+---+----+--++-+
++--++
--+--+++-++
+-+---+++-+
++-++-----+
-----+
--+--+
--+++-+---+
-----+-++-+
--+--+-++-+
-++----+--+
-++-++
--++----+-+
---+++
+++?++
+-+--++---+
+-+--+
-+-++--+--+-+--+-+?-+
-+-+++
+-+?-+
--++-++-+-+
-----+
-+++-+
++-+--+---+
--++---++--+-+++--+-++--++
-----+
++-+-+
----+--+--+---++--+--+++-+
+++-++
+++?-+
---+-+
+--+++
--++-++--+-+---++---+
++++++
+++--++-+++
-+---+
++---+
--+-++
++--++
-+---+--+---++-+
++-++-+++-+
--+--+
-+---+++-++
+-+--++++-+
-+++-+
--+-+-++-++
+--+-+
---+-+
+-++-+
+-+-++
---+-+
-----+
--++----+++
+-+--+
---+++-+-++
--+--+--+++
---+-+
--+---++?++
-++----++-+
++++++
--++++++--+
+++--+-++-+
+--+++
-+++------+
+-++++
+----+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.701
-1.7
1.699
1.699
1.698
-1.698
-1.698
-1.697
-1.697
1.696
1.695
-1.694
1.694
1.694
-1.694
-1.694
1.694
1.694
-1.694
1.693
1.693
-1.692
1.692
1.692
1.692
1.692
1.691
-1.691
-1.69
1.69
-1.69
1.69
-1.69
1.689
-1.689
1.689
-1.688
-1.688
-1.688
1.687
-1.687
-1.687
1.685
-1.685
1.685
1.685
-1.684
1.684
-1.683
1.682
1.682
-1.682
-1.681
-1.681
-1.681
-1.68
-1.68
1.68
-1.678
1.678
-1.678
-1.678
1.678
-1.677
-1.676
1.676
1.676
-1.675
1.675
1.675
-1.674
-1.673
-1.673
1.673
1.672
1.672
-1.671
1.67
-1.67
1.669
1.669
-1.669
-1.668
-1.668
-1.668
-1.668
1.666
-1.666
1.665
-1.665
-1.665
-1.664
-1.664
1.663
1.663
1.663
-1.662
1.662
-1.662
-1.662
-1.662
1.661
1.661
-1.66
1.66
-1.66
1.659
1.659
1.659
-1.658
-1.658
1.658
1.658
1.658
-1.657
-1.656
1.656
-1.655
1.655
1.654
-1.653
1.652
1.652
1.651
1.651
1.651
-1.651
-1.651
-1.65
1.65
1.649
-1.648
1.648
-1.648
1.648
1.647
-1.647
1.647
-1.647
1.647
1.645
-1.645
1.644
-1.645
1.644
1.644
-1.643
-1.643
1.644
-1.643
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
8.90E-02
8.91E-02
8.94E-02
8.94E-02
8.95E-02
8.95E-02
8.96E-02
8.97E-02
8.98E-02
8.99E-02
9.01E-02
9.02E-02
9.02E-02
9.02E-02
9.02E-02
9.02E-02
9.03E-02
9.03E-02
9.04E-02
9.04E-02
9.04E-02
9.06E-02
9.06E-02
9.07E-02
9.07E-02
9.07E-02
9.09E-02
9.09E-02
9.10E-02
9.10E-02
9.10E-02
9.11E-02
9.11E-02
9.12E-02
9.12E-02
9.12E-02
9.14E-02
9.15E-02
9.15E-02
9.15E-02
9.16E-02
9.17E-02
9.19E-02
9.20E-02
9.20E-02
9.21E-02
9.22E-02
9.23E-02
9.24E-02
9.25E-02
9.25E-02
9.26E-02
9.27E-02
9.27E-02
9.28E-02
9.29E-02
9.30E-02
9.30E-02
9.33E-02
9.34E-02
9.34E-02
9.34E-02
9.34E-02
9.35E-02
9.37E-02
9.37E-02
9.38E-02
9.38E-02
9.39E-02
9.40E-02
9.41E-02
9.42E-02
9.44E-02
9.44E-02
9.45E-02
9.45E-02
9.48E-02
9.48E-02
9.49E-02
9.51E-02
9.51E-02
9.52E-02
9.53E-02
9.53E-02
9.53E-02
9.53E-02
9.56E-02
9.57E-02
9.58E-02
9.60E-02
9.60E-02
9.60E-02
9.61E-02
9.62E-02
9.63E-02
9.64E-02
9.64E-02
9.65E-02
9.65E-02
9.65E-02
9.66E-02
9.67E-02
9.68E-02
9.69E-02
9.69E-02
9.69E-02
9.71E-02
9.72E-02
9.72E-02
9.72E-02
9.73E-02
9.73E-02
9.74E-02
9.74E-02
9.76E-02
9.77E-02
9.78E-02
9.78E-02
9.80E-02
9.81E-02
9.83E-02
9.85E-02
9.85E-02
9.86E-02
9.87E-02
9.87E-02
9.88E-02
9.88E-02
9.90E-02
9.90E-02
9.93E-02
9.93E-02
9.94E-02
9.94E-02
9.94E-02
9.95E-02
9.95E-02
9.95E-02
9.96E-02
9.96E-02
9.99E-02
9.99E-02
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
17228
5738
35862
60407
54479
68422
20510
41816
44871
32596
6459
20152
42679
53184
52634
66588
67998
44393
62332
52811
40544
13553
33141
57061
60451
18272
55002
5771
14746
48256
19482
29772
36254
9605
9918
39974
22024
61023
59845
3287
44442
34747
33281
21874
25979
54950
47969
46294
9838
36937
30088
36790
41237
2962
58869
12061
41834
32922
23607
46628
61163
36421
18822
35457
6402
37625
40668
56937
57701
39806
54584
10121
15509
45328
45699
30485
33449
43026
1846
46295
17908
25980
9788
32205
28560
40016
57200
37467
40478
2394
35032
43932
18490
53409
56726
40448
56770
8368
22433
30811
47632
51278
30547
39771
20428
65147
56918
46120
50866
42614
56548
66329
3277
52798
35561
46570
17503
21963
64114
37201
34438
52038
54887
13540
22299
48591
13416
30803
41270
63967
1577
13748
34227
41492
57720
59393
18177
37476
17580
20473
54594
23886
61770
11567
12099
15689
45952
5006
33365
57939
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
541565
147968
64769
51752
92344
79939
115098
80314
5435
84656
56952
57213
84240
25996
5519
6372
57405
3475
23639
7106
4043
6166
9650
259287
84464
5311
23023
283337
57700
64793
7098
10330
55063
57165
51157
57805
3638
3093
129563
6382
10466
391356
3069
9379
147007
128239
192111
402055
57701
84932
79845
2794
22838
56919
54809
79155
55166
1592
285464
2086
196074
84749
3706
4914
84557
51265
51204
51016
2538
286336
23461
286075
2673
260429
23293
9525
59269
84934
256144
27148
201931
285513
9204
54472
9156
7109
215
203569
84334
54840
3238
5290
22794
442184
7373
57794
51149
7374
126364
79648
282991
8604
9507
114327
126308
51294
283985
6320
8209
5528
3930
85442
550
50615
25828
5718
55829
27145
6631
1850
3127
5883
6777
125111
127002
682
5805
1982
100129828
374969
9013
396
1370
871
7056
140876
22881
283310
55929
5616
84984
146512
22864
128866
1130
51147
26519
57798
23568
285754
C8orf58
CAPN12
MEAF6
ERAP1
GORAB
SLC35E1
CCDC124
EPC1
POLR2F
GLYR1
PRTFDC1
SPRYD7
ZCCHC9
REXO2
PPP2R1B
CXCL6
SPC25
IFRD1
LRRC6
TSPAN4
LRPAP1
RPL36AL
MTFR1
TAS2R41
SLX4
PKD2
TMCC1
ZNF740
FAM160B1
CEP85
TLR3
CNPY2
ZCWPW1
GJC2
ZNF580
KIAA1967
INSIG1
UBE2K
DIS3L2
SDC1
COG5
PTRHD1
HDLBP
NRXN2
TMEM199
IQGAP3
PGAM5
SRRD
NCKAP5L
RAB2B
RNF122
GNL1
RNF44
DHX33
SAMD9
TNIP2
CENPQ
CYP26A1
CRIPAK
ERV3-1
METTL15
USP30
ITPKA
NTRK1
MAP1LC3A
CDKL3
TACO1
EMC9
G6PC
FAM78A
ABCA5
ZNF707
GFPT1
PRSS33
SMG6
VPS4B
HIVEP3
C12orf52
OR4C3
STK36
TMEM192
GPRIN3
ZMYM6
TOLLIP
EXO1
TRAPPC10
ABCD1
PAGE2
APOPT1
APTX
HOXD12
PIK3CA
CASC3
OR2B3
COL14A1
SUGP1
C5orf45
UNG
LRRC25
MCPH1
BLOC1S2
SLC25A12
ADAMTS4
EFHC1
MOB3A
PCDH12
FADS6
CLEC11A
C21orf33
PPP2R5D
LBR
KNDC1
AUP1
IL21R
TXN2
PSMD12
VIMP
FILIP1
SNRPC
DUSP8
HLA-DRB5
RAD9A
STAT5B
GJD3
ATXN7L2
BSG
PTS
EIF4G2
TSPAN14
CCDC23
TAF1C
ARHGDIA
CPN2
SERPINH1
THBD
FAM65C
ANKRD6
OTOGL
DMAP1
PRKY
CEP19
FLJ30679
R3HDM2
CHMP4B
LYST
ING4
TIMM10
GATAD1
ARL2BP
FLJ37396
--+------------+
++-++---++++++++
++-+++
---+------+
++++-+
+-++-+-+----++-+
++-+++
+------+-----+---++++
+-+++-+++-+
++++-+
--++---++-+--+-++---+
+++-++
+-++-+
---+-+-+--+
++---+
+---++
---+----+-+
-+--++
---?---++-+
+-++++-+---+-+++
++++++
+-+-----+++
++-+++
+---++
--+--+
++++++
---+-+
+++++++++-+
++-?++-++-+
-+--++----+
-----+
+-+++++++-+
--+-++++++++--++
+-+++-+-++-+++++
-----+
-+++++
-++--+
---+--+---+
++-+-+
++--++
-+---+-+-+---+++
-----+
++++--+-+-+-+---+-+-+
-+---+
-+-+-++--++
--++-+
++-+++
+--+++
++++----+-+-+--+
+-++-+
++--++++------++
-----+-++-++-+++++++++-?++
--+--+
----++--?-+
+++--+
-+++---+--+----++-+++
--++-+++--+
-++?++
+-+?++
-----+
-----+
-+++-+
--+-++
+-++++
+++--+
-+--++
+-++-+
--++---+--++---+
---+-+
++---+
-+--+++---+-+----------+-+
++-+++-++--+++++
++-?-+
-+-++-----+
++++-+
+++-++
-----+
--+--++-++++-+++
++++++
-----+
+---+++++--+-++--+?---+-++-+--+
--++++
-+++++
+-++-+
----++
++++-+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
-1.643
-1.642
-1.643
1.642
-1.642
1.641
1.64
-1.641
-1.64
1.64
-1.639
-1.639
-1.639
1.638
-1.638
-1.637
-1.638
1.637
1.637
1.636
1.635
-1.635
-1.635
-1.635
1.635
1.634
1.635
-1.633
1.633
1.632
1.631
-1.631
-1.63
-1.629
-1.627
1.627
1.626
-1.626
1.625
1.625
-1.625
1.624
1.624
1.623
-1.623
1.623
-1.622
1.622
1.621
-1.621
1.621
-1.62
-1.62
-1.619
1.619
1.619
-1.618
1.618
1.617
1.616
-1.615
1.614
-1.613
1.613
-1.612
-1.612
-1.612
1.612
1.612
-1.611
-1.611
1.61
-1.61
1.61
-1.61
-1.61
1.61
-1.609
-1.608
1.608
-1.608
1.608
1.607
1.607
-1.607
1.607
1.606
-1.606
-1.606
-1.605
-1.605
-1.605
1.604
1.603
1.603
-1.602
-1.602
-1.601
1.6
-1.6
-1.599
-1.6
1.599
-1.599
1.598
1.598
1.597
-1.597
-1.596
1.596
1.596
1.596
1.595
-1.595
1.594
-1.595
-1.594
1.594
-1.594
1.594
-1.593
-1.593
-1.593
-1.592
-1.592
1.592
-1.591
1.591
1.591
1.59
-1.59
1.59
1.59
-1.59
-1.59
1.59
1.589
1.589
-1.588
-1.587
1.587
-1.586
-1.587
-1.586
1.586
1.586
1.586
1.585
-1.585
1.585
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.00E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.01E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.02E-01
1.03E-01
1.03E-01
1.03E-01
1.03E-01
1.03E-01
1.03E-01
1.04E-01
1.04E-01
1.04E-01
1.04E-01
1.04E-01
1.04E-01
1.04E-01
1.04E-01
1.04E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.05E-01
1.06E-01
1.06E-01
1.06E-01
1.06E-01
1.06E-01
1.06E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.07E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.08E-01
1.09E-01
1.09E-01
1.09E-01
1.09E-01
1.09E-01
1.09E-01
1.09E-01
1.09E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.10E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.11E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.12E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
63819
59151
10987
24111
51390
4459
37255
62187
9757
26121
777
46818
53088
63716
27125
10105
24386
17892
18714
23236
24211
57839
37792
873
27705
45305
63078
45142
16015
25076
33749
67078
15233
23707
31813
28154
5692
49835
2266
44002
25904
51716
61874
28826
45220
4010
24450
35365
37802
58189
24316
64672
37191
26765
19907
38879
17526
61658
61310
35191
62039
33419
3341
31700
8831
30176
19074
28278
17584
18278
41573
29619
42153
356
48502
17224
22142
53093
28476
43991
65212
3709
33364
39870
55134
7803
26728
35195
65524
67503
1133
62798
66641
1466
42617
4394
15144
24031
6312
24637
20190
7754
13186
50865
45345
14133
22152
24961
52959
1153
2307
20273
45047
66348
53163
62625
3282
35414
25137
51392
59913
63429
14465
57922
60256
830
3301
33823
6721
40599
51586
64036
53403
21863
38495
214
21096
11255
30172
52615
42457
23552
60688
18167
38102
55369
55519
67438
38656
10471
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
25981
9087
4725
54
9953
7088
254065
219
113763
51187
79643
5318
54788
54843
8558
7390
397
25847
64137
162466
128272
9107
79734
7412
22976
1815
252839
9547
6019
201163
57763
39
7566
3710
221458
126321
10365
54957
26146
3837
3682
114088
6305
92799
343035
201973
116512
1213
128312
51141
10974
92014
51362
3747
100129828
10237
55374
10623
9895
6670
3216
55741
92002
79102
10636
8621
57121
222484
9016
51634
5795
3099
890
8440
3508
401232
84515
10566
124359
114876
3373
29099
1136
2729
27134
151
9955
11253
148398
148479
3227
8293
25862
5194
255394
202020
129303
8417
9111
64218
49856
85236
51239
79929
57464
23118
2114
5295
7389
153328
53
79864
2804
8717
84892
10238
5356
10062
118472
23456
57101
10086
79740
22985
51334
64207
6150
23033
7293
26043
27248
161779
51320
2735
123096
2778
8336
2267
29044
1840
54856
79971
23105
283237
6598
5650
130074
5591
29959
9375
DNAH1
TMSB4Y
NDUFS5
ACP5
HS3ST3B1
TLE1
BRWD3
ALDH1B1
ZBED6CL
RSL24D1
CHMP6
PKP2
DNAJB12
SYTL2
CDK10
UROS
ARHGDIB
ANAPC13
ABCG4
PHOSPHO1
ARHGEF19
MTMR6
KCTD17
VCAM1
PAXIP1
DRD4
TMEM9
CXCL14
RLN2
FLCN
ANKRA2
ACAT2
ZNF18
ITPR3
KIF6
MFSD12
KLF2
TXNL4B
TRAF3IP1
KPNB1
ITGAE
TRIM9
SBF1
SHKBP1
RD3
CCDC111
MRGPRD
CLTC
HIST3H2BB
INSIG2
ADIRF
SLC25A51
CDC40
KCNC2
TJP1
SLC35B1
TMCO6
POLR3C
TECPR2
SP3
HOXB6
EDEM2
FAM58A
RNF26
RGS14
CDK13
LPAR5
LNX2
SLC25A14
RBMX2
PTPRJ
HK2
CCNA2
NCK2
IGHMBP2
LINC01011
MCM8
AKAP3
CDYL2
OSBPL1A
HYAL1
COMMD9
CHRNA3
GCLC
TJP3
ADRA2B
HS3ST3A1
MAN1B1
SAMD11
PHF13
HOXC11
SERF1A
USP49
PEX13
TCP11L2
TAPT1-AS1
TMEM150A
STX7
NMI
SEMA4A
WRAP73
HIST1H2BK
ANKRD39
MAP6D1
STRIP2
TAB2
ETS2
PIK3R1
UROD
SLC25A48
ACP2
C11orf63
GOLGB1
TRADD
GTDC2
DCAF7
PLRG1
NR1H3
ZNF511
ABCB10
ANO2
HHLA1
ZBBX
ACIN1
PRR16
IRF2BPL
MRPL23
DOPEY1
TNFRSF4
UBXN7
ERLEC1
PGBD4
MEX3C
GLI1
SLC25A29
GNAS
HIST1H2AM
FGL1
C9orf38
DTX1
GON4L
WLS
FSTL4
TTC9C
SMARCB1
KLK7
FAM168B
PRKDC
NRBP1
TM9SF2
++-+++
---+----+-+
+---++
-+-----+--+
+-+?----+--++-++
---++++-+-+
-++-++
-+--++
++-+-+
+----+
----+++++---+--+
++++-+
+++++-+---+
+-+?-+
+-+--+
+++--+
+----+
--+--+
---+-+
++-++----+-+-+++
+-+-+---?++
+++?+++--++
-+++++
+++?++
+--?---++-+---++-++-+
---?-+
+-++-+
+----+
++---+
+++-++
-----++--++
+-++-++-+-+
--+--++---+
+-+-+--++-+
+++-++
---?++
-+++++
-----+
---+-+
+-+--+-+--+
++-++++++-+
---+-+
++-+-+
-++--+
-+---+
-+---+
+-++---++-+++-++
+-++-+-+?-+
--++-+-+--++--++
+++-+---+-++--++
+-+--+
-++---++-++
-+-+-+
-+++++
+-++++----+-++++
+---++
++--++
+++-++
-----+
+++--+
+-++++
+++--+
--++++
+++++--+--+
-+-+++
+-+?++
+-++++++--+
-++--+
+++++++--++
-----+
+++-++
+-+--+-++++
+---+++-?++
++++-+--+-+
+----++++++
+++-++
-----+
+----+
---++++++-+
---+-+
+-+--+++-++
++-+++
-+++-+
+----+
++-+++-++++
---+-+
+-+-++-++-+
-+++-+
+--+--+--++
+-+--+
--++-+
-++?-+
-----+
-----+
+++--+
+-------+-+--+-+
+-+--++-+++
--++-+
-+---+
++-+-+
-+---+
-++++++++-+
+-++-+
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
6376
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.585
-1.584
-1.583
1.584
-1.584
-1.583
-1.583
-1.583
1.583
-1.583
1.582
1.582
1.582
1.581
-1.581
-1.581
1.581
-1.58
1.58
1.58
-1.58
1.579
1.578
1.577
-1.577
-1.577
-1.577
1.576
-1.575
1.575
-1.575
-1.575
1.574
-1.574
1.573
1.573
-1.572
-1.572
-1.571
1.571
-1.57
1.57
-1.57
1.57
1.569
-1.569
1.569
1.569
1.568
-1.569
1.567
-1.567
-1.565
1.565
1.565
1.564
-1.564
-1.564
-1.563
-1.562
1.562
1.562
-1.561
1.56
1.559
-1.559
-1.559
-1.559
-1.558
1.557
1.557
1.556
-1.557
-1.556
1.556
1.554
-1.554
1.555
1.554
-1.554
1.553
1.553
1.553
1.552
-1.552
1.552
1.552
1.551
1.551
-1.55
1.549
1.549
1.549
1.548
1.548
-1.547
1.546
1.546
1.546
1.546
1.544
1.543
1.543
-1.543
1.543
-1.542
1.541
-1.541
1.54
1.539
1.538
-1.538
1.538
1.538
-1.538
-1.537
-1.537
1.537
1.537
-1.537
1.537
1.536
1.536
-1.536
1.535
1.534
-1.534
-1.534
1.533
1.533
-1.533
-1.533
1.532
1.531
1.531
-1.531
-1.531
1.53
-1.53
-1.53
1.53
-1.53
1.529
-1.528
-1.528
1.528
-1.528
1.528
1.527
1.527
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.13E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.14E-01
1.15E-01
1.15E-01
1.15E-01
1.15E-01
1.15E-01
1.15E-01
1.15E-01
1.15E-01
1.15E-01
1.15E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.16E-01
1.17E-01
1.17E-01
1.17E-01
1.17E-01
1.17E-01
1.17E-01
1.17E-01
1.17E-01
1.17E-01
1.18E-01
1.18E-01
1.18E-01
1.18E-01
1.18E-01
1.18E-01
1.18E-01
1.18E-01
1.18E-01
1.18E-01
1.19E-01
1.19E-01
1.19E-01
1.19E-01
1.19E-01
1.19E-01
1.19E-01
1.19E-01
1.19E-01
1.20E-01
1.20E-01
1.20E-01
1.20E-01
1.20E-01
1.20E-01
1.20E-01
1.20E-01
1.20E-01
1.20E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.21E-01
1.22E-01
1.22E-01
1.22E-01
1.22E-01
1.22E-01
1.22E-01
1.22E-01
1.23E-01
1.23E-01
1.23E-01
1.23E-01
1.23E-01
1.23E-01
1.23E-01
1.23E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.24E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.25E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.26E-01
1.27E-01
1.27E-01
1.27E-01
1.27E-01
1.27E-01
1.27E-01
1.27E-01
14266
60890
23560
32466
47341
4005
13846
23650
43367
47700
68060
59118
65015
14367
33554
53923
54059
23022
64147
42451
16404
42218
54359
28444
64159
4999
66018
3258
58492
10413
55407
34403
20069
17587
57975
66283
34825
22780
66840
10439
63364
41660
37519
40182
27121
27791
45409
50271
62528
8570
30680
41105
50379
37639
56574
18214
14776
17802
58769
2182
17343
45076
13848
51935
1925
16102
27773
6141
32943
58109
23276
59310
2025
37561
60150
67282
16844
57853
6665
60638
62967
29037
50223
44461
45077
60447
42124
59023
6574
13808
45734
51440
26253
62478
15893
31559
57170
34269
2487
39399
54069
11368
23299
9397
10163
14754
38291
43676
50651
9748
28271
62579
6876
3146
60822
68131
22316
23086
24063
29660
54682
17207
49645
47854
46615
4074
7948
45191
57234
38871
67611
52481
68153
30075
40681
50010
11928
45228
48216
51957
22228
53330
58507
9685
45099
57356
1967
13212
34639
65959
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
57502
10106
259236
26128
64766
93129
8729
57151
5689
6666
1154
7690
257202
8847
1981
10564
54808
65059
163
23241
134510
51540
10693
2532
28999
6342
23466
5546
10868
80834
284004
83988
79640
7629
85378
821
55012
1301
4238
10863
54494
5618
5826
10965
116113
81029
23163
80237
222229
115908
25896
79803
3446
84258
3043
116841
219333
54662
8511
10380
54858
8233
80332
862
51339
1073
23030
122961
5711
55752
219402
9859
3032
11135
10287
1983
10864
2038
55147
6532
58533
50805
4618
10973
27115
64856
90864
285492
146722
9749
3304
26276
27033
6776
23594
753
29896
79957
567
3550
80737
1382
1948
63940
94160
94137
201255
8140
3716
23608
58986
6940
10098
348793
9973
5064
26093
1603
55972
26586
11329
10254
53615
1103
65996
6406
8398
8317
2475
8780
4638
51619
149371
2251
2780
54739
417
2801
79072
91624
90196
5912
90809
375513
23062
10479
10307
5300
1312
26995
NLGN4X
CTDSP2
TMIE
KIAA1279
S100PBP
ORAI3
GBF1
LYZL6
PSMB1
SOX12
CISH
ZNF131
GPX6
DLEU2
EIF4G1
ARFGEF2
DYM
RAPH1
AP2B1
PACS2
UBLCP1
SCLY
CCT6B
DARC
KLF15
SCP2
CBX6
PRCC
USP20
TAS1R2
HEXDC
NCALD
C22orf46
ZNF76
TUBGCP6
CANX
PPP2R3C
COL11A1
MFAP3
ADAM28
C11orf71
PRLR
ABCD4
ACOT2
FOXP4
WNT5B
GGA3
ELL3
LRWD1
CTHRC1
INTS7
HPS6
IFNA10
SYT3
HBB
SNAP47
USP12
TBC1D13
MMP23A
BPNT1
PGPEP1
ZRSR2
ADAM33
RUNX1T1
DACT1
CFL2
KDM4B
ISCA2
PSMD5
SEPT11
MTIF3
CEP170
HADHB
CDC42EP1
RGS19
EIF5
SLC22A7
EPB42
RBM23
SLC6A4
SNX6
IRX4
MYF6
ASCC3
PDE7B
VWA1
SPSB3
FLJ35424
CD300LF
PHACTR2
HSPA1B
VPS33B
ZBTB32
STAT5A
ORC6
LDLRAD4
TRA2A
PAQR6
B2M
IK
VWA7
CRABP2
EFNB2
GPSM3
ABCC12
RP1L1
LRRC45
SLC7A5
JAK1
MKRN1
TMEM8A
ZNF354A
TSPAN5
WDR53
CCS
PALM
CCDC9
DAD1
SLC25A40
CKAP2
STK38
STAM2
MBD3
CHAT
RPL23AP79
SEMG1
PLA2G6
CDC7
MTOR
RIOK3
MYLK
UBE2D4
EXOC8
FGF6
GNAT2
XAF1
ART1
GOLGA2
FASTKD3
NEXN
SYS1
RAP2B
TMEM55B
GUSBP1
GGA2
SLC9A6
APBB3
PIN1
COMT
TRUB2
++--++
---+--+---+
+---------+
++++-+
++-+-+
-+++++
--++-+
++-+++
++-+++
--++-+-++-+
+++++-+---+
-+--+-+++++---++
++-+++---++
--++-+----+
-----++-++-++-++
+++--+
++-+-+
+++++--++--+-+++
-+++-+
++-+++
+---+++---+
+----+
---+-+
+-++-+++-++
--+--+
--++-+-+-+++++++
+--+++
----++--+++
-+++++++--+
-----+
+++--+
++--++
+--+-+
-+-+++
+++++++++++
++-?+-+---+
++-+--+-?++
++++--------+--+
++--+++-+++
+-+-++
+------+?-+++--+
--+++---+-+-++-+
-+++-++++++
--+--+
-+++++
+-++-+
--+---+--++
++-++-+++-+
++--+++++-+
--+?++
+---++
+-+----+--+++++++-?++
+--+-+
+--+-+
---++-----+
++-+++
---+-+
+----+
+++-----++++--++
-++--+
+++++---?-+
+--+++
-++--+
+++-++++?-+
++++++
--++-+
+++--+
++-++-----++-++++++-+
--+-++
++-++--++--+-++-++-++
++++-+
-----+
--++++
+-++-++-+++
--++-+
-+-+-+
+-++-+
+++--+
+++-++++--+
+-----+--++
+++++++-+-+--+++
-+++-+
+-++++
--++++
++++-+--+++
-+---+
--++-+++++---+-+-++-+
-+----+-+------+
+--+++
+----+
-+-+++
-+-+++
-----+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.526
-1.525
-1.524
-1.523
-1.522
1.52
1.52
1.52
1.52
1.52
1.519
-1.519
1.519
1.519
-1.518
-1.518
1.518
1.517
1.517
1.517
-1.517
-1.517
-1.516
1.514
1.514
1.513
1.513
1.513
-1.513
1.512
1.511
1.511
-1.51
-1.509
-1.509
-1.509
1.509
1.509
-1.508
-1.508
-1.507
1.507
1.507
-1.507
1.505
1.505
1.504
-1.504
1.504
1.504
1.503
1.503
1.503
1.502
-1.501
-1.501
-1.5
1.5
1.5
-1.499
1.499
-1.498
1.498
1.496
-1.496
-1.495
1.496
-1.495
-1.495
1.494
-1.494
1.494
1.494
1.494
1.493
-1.492
1.492
1.492
1.491
1.492
1.492
1.491
1.491
-1.491
-1.49
1.491
1.49
1.49
1.489
-1.489
-1.488
1.488
1.488
-1.488
1.487
-1.487
1.487
1.486
1.486
-1.485
1.485
1.485
1.484
1.484
1.484
1.484
1.484
1.482
-1.483
1.482
1.482
1.482
1.481
-1.481
1.481
1.481
1.48
-1.48
1.48
-1.48
1.479
1.479
-1.479
1.478
1.478
1.478
1.477
-1.477
-1.477
1.477
-1.477
1.477
1.477
1.476
1.476
1.476
1.476
-1.476
-1.476
1.475
-1.474
1.474
-1.474
-1.473
-1.473
1.473
-1.472
1.472
1.472
-1.472
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.27E-01
1.27E-01
1.28E-01
1.28E-01
1.28E-01
1.28E-01
1.28E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.29E-01
1.30E-01
1.30E-01
1.30E-01
1.30E-01
1.30E-01
1.30E-01
1.30E-01
1.31E-01
1.31E-01
1.31E-01
1.31E-01
1.31E-01
1.31E-01
1.31E-01
1.31E-01
1.31E-01
1.32E-01
1.32E-01
1.32E-01
1.32E-01
1.32E-01
1.32E-01
1.32E-01
1.32E-01
1.33E-01
1.33E-01
1.33E-01
1.33E-01
1.33E-01
1.33E-01
1.33E-01
1.33E-01
1.33E-01
1.33E-01
1.34E-01
1.34E-01
1.34E-01
1.34E-01
1.34E-01
1.34E-01
1.34E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.35E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.36E-01
1.37E-01
1.37E-01
1.37E-01
1.37E-01
1.37E-01
1.37E-01
1.37E-01
1.37E-01
1.37E-01
1.37E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.38E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.39E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.40E-01
1.41E-01
1.41E-01
1.41E-01
1.41E-01
1.41E-01
1.41E-01
1.41E-01
4548
42809
28459
52283
44188
14424
31132
62903
52228
53674
37428
58620
24921
31598
65045
28917
37133
38446
38551
22708
23874
29693
48210
7763
36470
1492
31958
48781
50765
63661
22769
15986
60209
66626
25644
5385
15056
43449
48114
57458
10886
42618
48367
38105
58471
15199
24592
21346
28836
4738
5327
15450
3392
9570
41330
24301
45880
6693
23745
15983
17334
1880
52217
9105
8988
34731
42403
54528
41850
27407
30772
57219
56614
59528
15197
68323
11535
37067
3245
23561
39869
8091
10292
50422
27867
68560
52805
30491
43527
63921
1424
31363
12202
33851
26210
38546
59961
68008
41735
9548
17197
19177
31479
49316
18589
35589
19170
46364
49804
53262
64273
10169
40906
65474
32477
36373
13907
38048
28074
17198
52290
2208
47066
30211
6560
57728
36112
59677
32381
33307
61822
12565
14426
39420
67045
27533
45866
27007
44729
63274
23136
29256
29481
3284
67375
25897
29946
34953
63369
36674
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
10849
10473
64847
54503
57448
56971
57533
9821
8727
6307
196441
375484
8622
92359
4939
10945
1604
2275
55283
5692
6582
84292
9402
220032
55054
286354
26137
25898
9939
55165
3612
8513
23478
7376
414328
199
151278
515
94005
66000
1595
63925
27090
5916
148156
22905
79172
54704
26505
5142
254427
170394
3627
92610
7534
3191
284085
580
284040
54512
8848
6840
79036
404093
29960
10472
283991
2842
54964
100133941
122553
176
399664
29887
65065
7542
54974
56311
7472
83879
84536
2140
54973
123207
85021
25813
7520
100129828
2150
122011
1478
146395
51013
3119
8836
171017
93953
92715
5985
9673
10382
3752
79585
149095
64333
10845
85464
10006
54851
5291
57147
9957
55663
51105
11043
400077
8502
4045
2857
3049
388569
116984
868
1053
80139
80023
11319
50804
22997
285492
9610
55907
24146
149466
219736
57630
10943
11061
4803
92086
3024
140707
51507
148254
5743
10025
51207
387837
10403
1778
CD3EAP
HMGN4
SPATA20
ZDHHC13
BIRC6
CEACAM19
TBC1D14
RB1CC1
CTNNAL1
MSMO1
ZFC3H1
SIMC1
PDE8B
CRB3
OAS2
KDELR1
CD55
FHL3
MCOLN3
PSMB4
SLC22A2
WDR83
GRAP2
GDPD4
ATG16L1
C9orf130
ZBTB20
RCHY1
RBM8A
CEP55
IMPA1
LIPF
SEC11A
NR1H2
IDNK
AIF1
CCDC140
ATP5F1
PIGS
TMEM108
CYP51A1
ZNF335
ST6GALNAC4
RARG
ZNF558
EPN2
CENPO
PDP1
CNNM3
PDE4B
PROSER2
PWWP2B
CXCL10
TIFA
YWHAZ
HNRNPL
KRT18P55
BARD1
CDRT4
EXOSC4
TSC22D1
SVIL
KXD1
CUEDC1
FTSJ2
ZBTB18
UBALD2
GPR19
C1orf56
CD24
TRAPPC6B
ACAN
MEX3D
SNX10
NBEAL1
ZFPL1
THG1L
ANKRD7
WNT2
CDCA7
C21orf67
EYA3
CPSF3L
C15orf40
REPS1
SAMM50
XRCC5
C3orf75
F2RL1
CSNK1A1L
CSTF2
GSG1L
EXOSC1
HLA-DQB1
GGH
ZNF384
ACRC
DPH7
RFC5
SLC25A44
TUBB4A
KCND3
CORO7
DCST1
ARHGAP9
CLPX
SSH2
ABI1
ANKRD49
PIK3CB
SCYL3
HS3ST1
ZNF446
PHF20L1
MID2
FLJ42957
PKP4
LSAMP
GPR34
HBQ1
ZNF324B
ARAP2
CBLB
CEBPE
ZNF703
NRSN2
ECD
MYEF2
IGSF9B
AX747702
RIN1
CMAS
CLDN15
C1orf210
STOX1
SH3RF1
MSL3
LECT1
NGF
GGTLC1
HIST1H1A
BRI3BP
RTFDC1
ZNF555
PTGS2
MED16
DUSP13
CLEC12B
NDC80
DYNC1H1
++++-+
+-++++
++-+-+
+-++++
--+--+-+-++
+-+-++
+-+--++++---++-+
+-++-+----+
++-+++
-+-+++
++++-+
-+++++
+-++-+
-+++++
++-++-+-+-+
+++--+
-+-+-+
+++++-++-++
---+-+
+++---+-----++++-++++
--++-+
--+-+--++++
--++-+++-++
+---++
---+-++--++
--++--++--+
---++++++-+
-+---+
++-+++-++++----+++--+
-+---+
+++--+
-+---+
+++--+
+--++++--++
-+++++
+-+----+++----------+
++++++---++
--++-+
+++?+-+---+
--+--+
-+++++
----++
+-++-+
-++--++++++
--+--+
--++++
+-++-++-+-+
++-+++
+-++-+
---+++-++-+
--++++
-++++--++-+
+--+-+
--++++
++-+++
-----+
-+-++----+----++
-+++-+
-++-++
+-+--+
+-++++
+----+
+-+-++
---+-+
++-++--+--+
--+--+
--+--+--+-+
-----+
+-+--+
++-+++
++--++
++-+-+
-+++++
+-+--+
-+++-+++-++
+-+--+---++-++-+
-----+
---+-+--+++
+++++++--++++-++
+----++++++
+-+--++-++-----+
-+-+-+
-+--+++-+-+
++++-+
+++-++
--+-+--++++---+++--++
+-++-+
+---+++-+-+
+++--+
-+--+-----+
-+++-+
-+++++
+---++
--++-+-++++
-+++++
+-++++
--+--+
+-+---++++-+++++
++++-+
+-++-++---+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.472
1.471
1.471
1.47
-1.469
1.469
1.469
-1.468
-1.468
1.468
-1.467
-1.467
1.467
-1.467
1.467
1.466
1.466
1.466
1.465
1.465
1.465
-1.464
-1.464
1.464
-1.464
-1.464
-1.463
-1.464
1.463
1.463
-1.462
1.462
-1.461
1.46
1.459
-1.458
1.459
-1.458
1.458
-1.458
1.457
1.457
1.457
1.457
-1.457
1.456
1.456
1.455
-1.455
1.454
-1.454
1.454
1.453
-1.452
-1.452
-1.451
-1.451
1.45
1.449
1.449
1.449
-1.448
1.448
1.447
-1.447
1.447
-1.447
1.447
1.445
1.445
-1.445
1.445
1.444
1.444
-1.444
1.443
1.443
1.442
1.442
1.442
1.441
1.44
-1.44
1.44
-1.439
-1.439
1.438
1.438
-1.438
1.437
-1.437
1.437
-1.437
1.436
-1.436
-1.435
-1.434
-1.434
-1.433
1.433
1.433
1.432
1.432
1.432
1.432
-1.432
1.431
-1.431
-1.431
1.431
-1.431
-1.43
1.43
1.43
1.429
1.429
-1.429
1.429
-1.428
1.428
-1.428
1.427
-1.427
1.427
1.426
1.426
-1.425
-1.425
-1.425
1.424
1.424
-1.424
1.424
1.423
-1.423
-1.422
1.423
1.422
1.421
-1.421
1.421
1.421
1.421
-1.42
-1.421
1.419
1.419
1.419
-1.419
1.419
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.41E-01
1.41E-01
1.41E-01
1.42E-01
1.42E-01
1.42E-01
1.42E-01
1.42E-01
1.42E-01
1.42E-01
1.42E-01
1.42E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.43E-01
1.44E-01
1.44E-01
1.44E-01
1.44E-01
1.44E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.45E-01
1.46E-01
1.46E-01
1.46E-01
1.46E-01
1.46E-01
1.46E-01
1.46E-01
1.47E-01
1.47E-01
1.47E-01
1.47E-01
1.47E-01
1.47E-01
1.47E-01
1.47E-01
1.48E-01
1.48E-01
1.48E-01
1.48E-01
1.48E-01
1.48E-01
1.48E-01
1.48E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.49E-01
1.50E-01
1.50E-01
1.50E-01
1.50E-01
1.50E-01
1.50E-01
1.50E-01
1.50E-01
1.51E-01
1.51E-01
1.51E-01
1.51E-01
1.51E-01
1.51E-01
1.51E-01
1.51E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.52E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.53E-01
1.54E-01
1.54E-01
1.54E-01
1.54E-01
1.54E-01
1.54E-01
1.54E-01
1.54E-01
1.54E-01
1.54E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.55E-01
1.56E-01
1.56E-01
1.56E-01
1.56E-01
1.56E-01
1.56E-01
1.56E-01
31872
68032
25728
50825
36810
57980
52800
46856
63151
3938
4401
10999
13253
2160
24120
41369
10771
14375
20715
62714
31457
42895
50429
57295
32876
61652
54660
25431
51700
45918
33115
40416
45544
55222
62557
17541
37595
3965
57991
62524
7006
17590
45230
49708
16521
4530
46983
47742
9470
1929
53797
59760
48394
60495
12836
42577
63695
15642
32166
54895
42957
67932
15224
57866
51886
62749
37616
54230
45459
62284
2714
2746
18251
19326
60240
28781
63389
44669
10264
67945
29102
35428
45596
16872
55560
59177
60698
31527
20144
27528
5845
37194
38463
16242
41550
45887
23901
44741
53444
44999
3604
3718
26306
12079
8620
55263
59070
22365
55789
61036
55200
3211
13465
61083
31592
66244
49402
27316
6887
39647
15789
33573
7490
43704
66518
26720
37458
67753
58172
67480
51837
55591
459
42481
44663
12405
11722
56218
65887
42629
52104
17808
930
36756
12103
63677
15209
15234
63715
120
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
7805
55757
79068
5879
7062
84109
54875
150596
340348
10950
5701
84626
8940
23682
64223
28959
54830
349565
5148
81704
114818
4712
50862
196968
80094
2033
79870
11335
3750
9674
338442
80031
284723
64838
58492
23630
25855
8515
7571
1915
56980
387748
11130
4034
1
10389
27247
6576
4122
51222
8668
27175
8710
8546
29075
7553
54768
81554
158135
84750
4675
9747
126205
23299
84541
5445
55646
10590
149461
157
6865
9275
23527
55090
80856
7469
1359
7428
57159
9677
28231
147
8535
51527
901
25793
25977
2980
7535
8613
4046
54455
5771
160365
7768
79095
57698
51501
4627
399512
7919
5609
204851
25928
2169
25961
51319
285237
89822
6626
81697
27072
9169
10671
816
6302
2572
9923
5279
55195
84279
1613
1958
153396
338811
389692
10233
84286
401554
64098
5201
10620
80263
4437
1500
6926
205251
55095
55290
56259
55628
5704
23554
7353
55504
55670
57326
29781
253980
5297
LAPTM5
UGGT2
FTO
RAC1
TCHH
QRFPR
CNTLN
FLJ32955
TSPAN33
BTG3
PSMC2
KRBA1
TOP3B
RAB38
MLST8
TMEM176B
NUP62CL
NMNAT3
PDE6G
DOCK8
KLHL29
NDUFB6
RNF141
DNM1P46
BIN3-IT1
EP300
BAALC
CBX3
KCND1
KIAA0040
HCAR2
SEMA6D
SLC25A34
FNDC4
ZNF77
KCNE1L
BRMS1
ITGA10
ZNF23
EEF1A1
PRDM10
OR56B1
ZWINT
LRCH4
A1BG
SCML2
NFU1
SLC25A1
MAN2A2
ZNF219
EIF3I
TUBG2
SERPINB7
AP3B1
LINC00652
ZNF7
HYDIN
WBSCR16
TTLL11
FUT10
NAP1L3
FAM115A
NLRP8
BICD2
KBTBD8
PON2
LYAR
SCGN
CLDN19
ADRBK2
TACR2
BCL7B
ACAP2
MED9
KIAA1715
NELFA
CPA3
VHL
TRIM54
PPIP5K1
SLCO4A1
ADRA1B
CBX4
GSKIP
CCNG2
FBXO7
NECAP1
GUCA2A
ZAP70
PPAP2B
LSP1
FBXO42
PTPN2
CLECL1
ZNF225
C9orf16
KIAA1598
C11orf73
MYH9
SLC25A35
DDX39B
MAP2K7
HIPK1
SOSTDC1
FABP2
NUDT13
RSRC1
C3orf38
KCNK17
SNRPA
OR2B2
VPS41
SCAF11
DCTN6
CAMK2B
TSPAN31
GAD2
ZBTB40
PIGC
C14orf105
PRADC1
DAPK3
EGR1
TMEM161B
FAM19A2
MAFA
LRRC23
TMEM175
FLJ46836
PARVG
PFDN1
ARID3B
TRIM45
MSH3
CTNND1
TBX3
LINC00116
SAMD4B
BRF2
CTNNBL1
ZNF407
PSMC4
TSPAN12
UFD1L
TNFRSF19
PEX26
PBXIP1
NCAPH2
KCTD13
PI4KA
-+++-+
+-+--+
-----+
+-+-++
+++-++
+++-+++++-++--++
++--++--+++
+-++++
++-+++
++-+++
+++--+
-+---+
+-++-+
--++----+--+-+++
+-+--+
-++-++
-+++-+-+-++
--+---++-++
++++-+
---+--++-+-+-+++
++-+-+
+-+--+-++++
-----+
++--++
-----+
-+++-+
-+-+++
-+---+
+---+---+-+
+-+-++
++++++
-++-++
-----+
-+++++
-+-+++
----+-+-+++
+-++-+
+++--+
---+-+
++--++
+-++++
+-++++
+++?+-----+
-+-+++
-----+
---++--++++
+----+++--+
+++--+
-++--+
----++-+--+-+---++--+
-+++++
+--+++
+-++++
++-+-+
+-+-++
---+-+-++------+
+-+-----?-+
-++-++
++--+-+--++
++++-+
-+++-+
--+-+--+--+
++-++--+--+
++++++
++-?++
-----+
-++?-+
--++++
--++-----+---+--+++-+-++-+
-+++-++--++
++--++
-+-+-+
++-+++
++-+++
++-+++
+++-++
--++-+
+-+++--++++
--+-----+-+
-+++++
+++--+
-+++---+--+
+-++++
-+-+++
---?+-+---+
---+++
++--++
++-+-+
-++--+
-----+
--++--++-++
+++-+-----+
++-+++
++--++
-+++-+
-+-++-+--++
++++-+
+++--+
++--+-++-++
---?+++-+-+
-+--++
-+-+++
---++-+-+-+
+---++
++-+++
--++-+
---+++
+++-++
-+---+
++---+
+----+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.418
1.418
-1.417
1.417
1.416
1.416
-1.415
1.414
1.414
1.414
1.414
1.414
1.414
1.413
-1.413
1.413
-1.413
-1.413
1.413
-1.412
1.412
-1.412
1.411
-1.412
1.411
1.41
-1.409
-1.409
1.409
1.409
-1.408
1.408
-1.408
1.408
-1.408
1.408
1.407
-1.407
-1.406
-1.405
1.405
1.404
1.405
-1.404
1.404
1.403
-1.403
1.404
1.403
1.403
-1.403
1.403
1.402
1.401
1.4
-1.399
1.399
-1.399
-1.399
1.399
-1.398
1.398
1.398
1.398
-1.396
-1.396
-1.395
1.395
1.394
1.394
1.393
1.392
1.392
-1.392
-1.393
-1.392
-1.392
-1.391
1.391
-1.391
1.391
1.391
1.391
-1.391
-1.39
1.39
-1.39
1.39
1.389
-1.389
1.388
1.388
-1.388
-1.387
-1.387
-1.387
1.386
-1.386
1.385
1.385
1.385
1.384
1.383
1.382
1.382
1.382
1.381
1.381
-1.381
-1.38
1.379
1.379
-1.379
-1.379
1.378
1.378
-1.377
-1.377
-1.376
1.376
1.376
1.375
-1.375
-1.375
1.375
1.374
-1.374
1.374
1.374
1.374
1.373
1.371
1.37
1.37
1.37
1.368
-1.368
1.368
1.368
1.367
-1.367
1.366
1.366
1.365
1.364
-1.364
1.364
-1.364
-1.364
-1.364
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.56E-01
1.56E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.57E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.58E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.59E-01
1.60E-01
1.60E-01
1.60E-01
1.60E-01
1.60E-01
1.60E-01
1.60E-01
1.61E-01
1.61E-01
1.61E-01
1.61E-01
1.61E-01
1.61E-01
1.61E-01
1.61E-01
1.61E-01
1.61E-01
1.62E-01
1.62E-01
1.62E-01
1.62E-01
1.62E-01
1.62E-01
1.62E-01
1.62E-01
1.62E-01
1.63E-01
1.63E-01
1.63E-01
1.63E-01
1.63E-01
1.63E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.64E-01
1.65E-01
1.65E-01
1.65E-01
1.65E-01
1.65E-01
1.65E-01
1.65E-01
1.65E-01
1.65E-01
1.65E-01
1.66E-01
1.66E-01
1.66E-01
1.66E-01
1.66E-01
1.66E-01
1.66E-01
1.67E-01
1.67E-01
1.67E-01
1.67E-01
1.67E-01
1.67E-01
1.67E-01
1.68E-01
1.68E-01
1.68E-01
1.68E-01
1.68E-01
1.68E-01
1.68E-01
1.68E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.69E-01
1.70E-01
1.70E-01
1.70E-01
1.70E-01
1.71E-01
1.71E-01
1.71E-01
1.71E-01
1.71E-01
1.71E-01
1.71E-01
1.72E-01
1.72E-01
1.72E-01
1.72E-01
1.72E-01
1.73E-01
1.73E-01
1.73E-01
1.73E-01
1.73E-01
1.73E-01
55549
47102
19268
35809
46795
52907
68172
22437
19328
62933
33265
57842
37609
22590
17553
49038
20794
52646
53221
19387
17195
40521
19699
28825
42212
3047
3447
36265
55454
55495
57997
60075
59053
61548
46799
64812
27940
9505
62034
64209
5510
12846
19154
3698
6929
23771
57969
63112
9896
59360
2944
19785
62614
3569
35240
56227
61484
56409
7815
54358
35450
49205
45128
42554
57372
61211
52732
24734
16207
37465
14535
22158
33249
21231
22628
26569
43785
54430
11711
13382
39768
50566
33022
24540
4640
37208
27410
41923
50192
17411
19032
16623
49614
28958
45554
51023
55673
39829
6066
45600
29420
39909
1648
17538
65529
14333
49392
3268
7005
56889
23723
2060
30168
55036
6669
29834
68228
18260
22572
58816
65546
26398
31114
61817
50588
37271
18660
43187
46421
34360
51502
42191
66220
30831
44453
24499
27485
36658
47598
8392
46623
24630
61344
8629
53030
67086
44099
28426
32223
39643
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
80352
55723
284992
10309
152065
389206
10570
6398
348110
130557
25930
6646
5719
255252
9877
81794
55288
54549
8086
10928
56122
283385
78990
266747
805
575
148137
200261
79677
5147
2280
54968
197335
27258
92822
56731
8078
81033
146050
81579
8887
51081
27330
50
57335
3098
124790
3840
23204
6540
84085
56241
1366
55830
124583
27301
64428
55168
56006
11270
57721
624
257000
216
89846
94056
5328
151194
10458
81562
2850
11230
285440
4233
219899
441932
50618
11345
55076
9419
1892
53635
64969
1105
84572
734
38
54537
26043
283635
55892
7586
79778
135458
177
4087
10156
4601
3360
55812
246175
203259
627
23436
1894
3163
219749
51533
5558
11177
149473
23365
79635
5695
55094
283487
84727
10428
2218
26507
54617
5289
253012
286257
5164
55471
84250
51286
9801
55351
130367
57088
84668
54913
84867
6199
7531
6752
10561
55233
7369
5156
1112
64581
9833
55275
10291
8722
6468
81576
RNF39
ASF1B
CCDC150
CCNO
C3orf22
BEND4
DPYSL4
SECTM1
C15orf38
ZNF513
PTPN23
SOAT1
PSMD13
LRRC57
ZC3H11A
ADAMTS10
RHOT1
SDK2
AAAS
RALBP1
PCDHB14
MORN3
OTUB2
RGL4
CALM2
BAI1
C19orf55
LINC00656
SMC6
PDE6D
FKBP1A
TMEM70
WDR90
LSM3
ZNF276
SLC2A4RG
USP5
KCNH6
ZSCAN29
PLA2G12A
TAX1BP1
MRPS7
RPS6KA6
ACO2
ZNF286A
HK1
HEXIM2
KPNA4
ARL6IP1
SLC6A13
FBXO30
SUSD2
CLDN7
GLT8D1
CANT1
APEX2
NARFL
MRPS18A
SMG9
NRM
METTL14
BDKRB2
TINCR
ALDH1A1
FGD3
SYAP1
PLAU
METTL21A
BAIAP2
LMAN2L
GPR27
PRAF2
CYP4V2
MET
TBCEL
OR2W5
ITSN2
GABARAPL2
TMEM45A
CRIPT
ECHS1
PTOV1
MRPS5
CHD1
GNPTG
OSGIN2
ACAT1
FAM35A
UBXN7
FAM177A1
MYNN
ZKSCAN1
MICALL2
HUS1B
AGER
SMAD2
RASA4
MXI1
HTR4
SPATA7
CNOT6L
FAM219A
BDNF
CELA3B
ECT2
HMOX2
ZNF25
PHF7
PRIM2
BAZ1A
CCDC24
ARHGEF12
CCDC121
PSMB7
GPATCH1
LOC283487
SPSB2
CFDP1
FKTN
CNNM1
INO80
PIK3C3
HEPACAM2
C9orf142
PDK2
NDUFAF7
ANKRD32
CEND1
MRPL19
STK32B
SGPP2
PLSCR4
FAM126A
RPP25
PTPN5
RPS6KB2
YWHAE
SSTR2
IFI44
MOB1A
UMOD
PDGFRA
FOXN3
CLEC7A
MELK
VPS53
SF3A1
CTSF
FBXW4
CCDC130
-+--++
--+--+
+++--+
+-+?++
++--++
-++--+
+--+++
+-+?-+
-+++-+
++++-+
++-+-+
+-++-+
-+++-+
+-+?-+
--+--+
++-+-+
--++----+-+
-+++-++++++--+++
--+?-++++++--+++
+-+++-+-+-+
+--++-++-++
+-++-+++--+
-++----++-+
-----+
---++++-+-+
----++
-+---+
+++--+
++-+++
+--+-+
-++++-----+
--+-+--------++-+-+++
+--++--++-+-+++-+++-+
+-+++----++
--+--+-++-+++--+
-+-+-+
-+---+
-+-+-+
-+-+-+
-+---+
-+-+-++++++
+-++++
--++-+
-----+
+-++++
--+--+
+++---++-++
--+?-+
--+--+
+--+-+
+---++--+-+
+++++++-+++++-++
+-+-+++++++-++++
-----+
-+-+-+
---+++
+-+---+---+
+-++-++-+++----+
-+-+++
++++---+-++----++++-+
-----+
+++-++
+-+----+++++-++-+++-+
++++----++-+-+++
-+++++
----++
+-+++-----+
+-+++++--++
+++-++
+++++++++-+
+++++--++---++++
---+-+
-+-+++
-+-++--++-+++--++-++++---+-++-+++++-+---+
++-+---++++
+-+--+-+-++
---+++-++-+
+----+
-+++++
--+-----+-+
---+-+
++-+++
---+-+++--+
-+++-+
--++-+
+-++++
+-+++++++++
--+++---++-+++-+
+----+
---+-+
++-------++
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.364
-1.363
1.363
1.363
1.363
1.362
1.362
1.361
1.36
1.36
1.36
1.359
1.359
1.358
-1.358
1.358
-1.357
-1.356
-1.356
1.355
1.355
-1.355
1.354
1.354
1.354
1.354
1.353
1.353
-1.353
1.353
-1.353
-1.353
-1.353
-1.352
1.351
-1.351
-1.351
1.35
1.35
1.35
1.349
-1.349
-1.349
-1.349
-1.348
1.349
1.349
-1.348
-1.348
1.348
1.348
1.348
-1.347
-1.347
1.347
1.347
-1.344
1.343
-1.342
1.342
-1.341
1.34
1.34
-1.34
-1.34
1.34
1.34
-1.339
1.339
-1.339
1.338
-1.337
-1.337
1.336
-1.336
1.336
1.335
-1.335
1.335
1.335
-1.335
-1.334
-1.333
-1.333
-1.333
1.332
-1.332
-1.332
1.331
1.331
-1.33
-1.33
1.33
-1.329
1.329
-1.329
-1.328
1.328
1.327
-1.326
-1.325
1.325
1.324
1.324
1.324
-1.323
1.323
1.323
1.323
1.323
1.322
1.321
-1.321
1.321
-1.321
1.321
-1.32
-1.32
-1.32
1.32
-1.32
-1.319
1.319
-1.319
-1.318
1.318
-1.318
1.318
-1.318
1.318
1.317
1.317
-1.317
-1.316
1.316
1.316
-1.316
1.315
1.315
1.314
1.314
-1.313
1.313
1.313
-1.311
1.311
-1.311
-1.31
-1.31
-1.309
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
1.73E-01
1.73E-01
1.73E-01
1.73E-01
1.73E-01
1.73E-01
1.73E-01
1.73E-01
1.74E-01
1.74E-01
1.74E-01
1.74E-01
1.74E-01
1.74E-01
1.75E-01
1.75E-01
1.75E-01
1.75E-01
1.75E-01
1.75E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.76E-01
1.77E-01
1.77E-01
1.77E-01
1.77E-01
1.77E-01
1.77E-01
1.77E-01
1.77E-01
1.77E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.78E-01
1.79E-01
1.79E-01
1.80E-01
1.80E-01
1.80E-01
1.80E-01
1.80E-01
1.80E-01
1.80E-01
1.80E-01
1.80E-01
1.81E-01
1.81E-01
1.81E-01
1.81E-01
1.81E-01
1.81E-01
1.82E-01
1.82E-01
1.82E-01
1.82E-01
1.82E-01
1.82E-01
1.82E-01
1.82E-01
1.82E-01
1.82E-01
1.83E-01
1.83E-01
1.83E-01
1.83E-01
1.83E-01
1.83E-01
1.83E-01
1.84E-01
1.84E-01
1.84E-01
1.84E-01
1.84E-01
1.84E-01
1.84E-01
1.84E-01
1.85E-01
1.85E-01
1.85E-01
1.85E-01
1.85E-01
1.85E-01
1.86E-01
1.86E-01
1.86E-01
1.86E-01
1.86E-01
1.86E-01
1.86E-01
1.86E-01
1.86E-01
1.86E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.87E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.88E-01
1.89E-01
1.89E-01
1.89E-01
1.89E-01
1.89E-01
1.89E-01
1.90E-01
1.90E-01
1.90E-01
1.90E-01
1.90E-01
1.91E-01
14078
25599
779
2941
36236
52796
39271
34634
52087
19583
55080
60609
41013
42695
66037
18317
38376
3832
21592
28577
67614
23737
47161
42400
68377
45828
50171
65742
3677
63268
5239
26642
54852
48951
12174
67816
5211
68467
24871
3410
28103
28896
49601
54253
13006
30111
44233
44660
34080
37708
57621
60193
25297
50092
53475
2256
37358
22642
67906
31843
18800
2682
63733
8508
36815
12072
48018
63899
24030
26113
65735
7911
34523
50868
39379
43505
13549
66191
10954
33746
2631
1528
63383
59648
46942
47927
3554
58177
31697
37460
18710
41717
47514
57333
790
14033
1220
27087
67406
49042
52561
26906
38852
23543
62408
29771
17839
15809
34780
40602
3684
13663
58211
60880
62545
45192
25622
4780
32462
11732
63259
41705
5728
37857
57964
37910
57365
16356
20483
26486
52440
57845
40019
45791
47859
54463
36355
28563
11992
30645
64403
6242
39314
54058
58630
19325
30308
26049
40809
15135
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
6476
253635
151525
5635
126328
1007
51079
3067
3576
196743
23270
5087
1193
10672
9001
5886
89891
10809
83444
64963
22843
54828
2145
85456
63932
9399
55721
130617
201181
3029
24144
1641
51172
84231
378464
154810
55270
9236
79029
2678
140461
162979
286319
91355
10554
79581
126133
10781
9978
22809
10870
404672
6494
6622
11086
2588
64754
219873
10468
56904
353088
3857
145447
56180
58493
85280
57510
26747
10181
22856
2230
219960
84324
80271
2868
22800
160140
112939
54868
152100
54850
60626
6257
71
84520
51768
140732
55751
23530
25819
54101
64927
64131
51649
4139
152015
84658
9980
26155
51605
351
22854
382
489
9883
134
4808
127602
51131
10190
79989
83463
4040
7100
11259
84964
23406
4649
26872
4090
83607
84848
7289
55236
56603
394263
374659
11020
10135
10226
6780
284241
84065
92922
1789
51125
10056
7711
2738
140710
64925
11164
267002
113235
11131
3777
51025
637
6239
8715
SI
GPATCH11
WDSUB1
PRPSAP1
NDUFA11
CDH9
NDUFA13
HDC
IL8
PAOX
TSPYL4
PBX1
CLIC2
GNA13
HAP1
RAD23A
WDR34
STARD10
INO80B
MRPS11
PPM1E
BCAS3
EZH1
TNKS1BP1
CXorf56
STOML1
IQCC
ZFAND2B
ZNF385C
HAGH
TFIP11
DCX
NAGPA
TRAF7
MORN2
AMOTL1
NUDT15
CCPG1
SPATA5L1
GGT1
ASB8
ZNF296
TUSC1
LRP5L
AGPAT1
SLC52A2
ALDH16A1
ZNF266
RBX1
ATF5
HCST
GTF2H5
SIPA1
SNCA
ADAM29
GALNS
SMYD3
OR10S1
FST
SH3GLB2
ZNF429
KRT9
ABHD12B
MOSPD1
INIP
KRTAP9-4
XPO5
NUFIP1
RBM5
CHSY1
FDX1
OR10Q1
SARNP
ITPKC
GRK4
RRAS2
C11orf65
NACC1
TMEM104
CMC1
FBXL12
RIC8A
RXRB
ACTG1
C14orf142
TM7SF3
SUN5
TMEM184C
NNT
CCRN4L
RIPK4
TTC23
XYLT1
MRPS23
MARK1
ROPN1B
EMR3
DOPEY2
NOC2L
TRMT6
APP
NTNG1
ARF6
ATP2A3
POM121
ADORA1
NHLH2
DNAH14
PHF11
TXNDC9
TTC26
MXD3
LRP6
TLR5
FILIP1L
ALKBH6
COTL1
MYO9A
STEAP1
SMAD5
AMMECR1L
MIR503HG
TULP3
UBA6
CYP26B1
MUC21
HDDC3
IFT27
NAMPT
PLIN3
STAU1
FLJ25715
TMEM222
CCDC102A
DNMT3B
GOLGA7
FARSB
ZNF155
GLI4
SOGA1
CCDC71
NUDT5
PGBD2
SLC46A1
CAPN11
KCNK3
PAM16
BID
RREB1
NOL4
-+--++
+-+++--++++
+-----+---+
++-+++
-+-+++
+-+----+--+--++-+-+-++-+++-++-+-+--++-+-+
-+-++-+---+++--+
-+-?--+---+
-++-++
-----+
++-?++
-----+
---?++--+-+-++-+
-+-+++
+-++-+
++-++-+---++-++++-+----+-+
+-+++++++++
+----+-++---+--+
++-+++++--+
-+--++
+-------+-+
++---+
++---+
-+--++
-----+++++-+-+-+
-+-+-+
---++-+-+-+
++-++-+--++
---+-+
--++-++-+-+
--++-++--+--++-++++-+
++++-+
-++----+--++-++-----+
--+-+-----+
+-+---+++-++-++-+++++
--+?-+
+++?+-+--+++--+++-+-+
-+-+-+
-------+--+
++-+-+
---+-+
+-++++
--++-+--+-+
-+-+-+
--+-++
++++-+
+-++-+
-++++++---+
---+++
-+-+-++---+
--+-++-++-+++--+
--+-+--+-+-+-+++
++-+++
--++-+
+++--+
---+--+++-+
++--++
-+--++--+-+-+++--+-+-+++-+
++++++-+-++-+-+++--++
+--+-+
++-++++---+
+-+-++
+-+-------+
++--++
+-+--+-+--+
--++-+
---++---+-+
++--++
+-++-+
+-+-+++---+
-++--+
-+---+
-+++++
--+?-+
+++++---+--+---+
---+-+
---+-+
+-++---+--+
++-+++
++--++
+--+++
+--+---+--+-+--+
++++++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.308
1.308
1.308
-1.308
-1.308
1.308
1.307
1.307
-1.307
-1.306
-1.307
1.306
-1.306
-1.306
1.305
-1.305
-1.305
1.304
-1.303
-1.303
1.303
1.302
1.302
-1.301
-1.301
-1.301
1.301
1.301
1.3
1.3
-1.3
1.299
-1.299
1.299
1.299
1.299
-1.299
1.299
-1.298
1.298
1.298
-1.297
-1.297
-1.297
1.297
1.296
-1.297
-1.296
1.296
1.296
1.296
-1.295
1.295
1.295
1.294
1.294
-1.294
1.293
-1.293
1.293
-1.291
1.289
1.289
-1.288
-1.288
-1.287
-1.287
-1.287
-1.287
-1.286
-1.285
1.285
1.285
1.285
1.284
-1.283
-1.283
1.283
1.281
-1.281
-1.281
1.281
-1.28
1.28
-1.279
1.279
1.279
1.279
1.278
1.278
1.278
1.277
1.276
-1.277
1.276
-1.275
1.275
1.274
-1.274
-1.274
1.274
1.273
1.273
1.273
-1.273
1.273
1.272
-1.272
-1.27
1.27
-1.269
1.269
-1.269
1.269
-1.269
1.268
1.268
1.267
-1.267
1.266
-1.266
-1.265
1.264
-1.264
1.264
-1.264
-1.264
-1.263
1.263
1.263
-1.263
-1.262
1.261
-1.261
1.261
-1.261
-1.26
-1.26
-1.259
-1.259
-1.258
-1.258
-1.257
1.257
1.257
1.257
-1.256
-1.256
1.256
1.256
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.91E-01
1.92E-01
1.92E-01
1.92E-01
1.92E-01
1.92E-01
1.92E-01
1.92E-01
1.93E-01
1.93E-01
1.93E-01
1.93E-01
1.93E-01
1.93E-01
1.93E-01
1.93E-01
1.93E-01
1.93E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.94E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.95E-01
1.96E-01
1.96E-01
1.96E-01
1.96E-01
1.96E-01
1.96E-01
1.96E-01
1.97E-01
1.97E-01
1.98E-01
1.98E-01
1.98E-01
1.98E-01
1.98E-01
1.98E-01
1.98E-01
1.98E-01
1.99E-01
1.99E-01
1.99E-01
1.99E-01
1.99E-01
1.99E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.01E-01
2.01E-01
2.01E-01
2.01E-01
2.01E-01
2.01E-01
2.01E-01
2.01E-01
2.01E-01
2.02E-01
2.02E-01
2.02E-01
2.02E-01
2.02E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.03E-01
2.04E-01
2.04E-01
2.04E-01
2.04E-01
2.04E-01
2.05E-01
2.05E-01
2.05E-01
2.05E-01
2.05E-01
2.05E-01
2.05E-01
2.06E-01
2.06E-01
2.06E-01
2.06E-01
2.06E-01
2.06E-01
2.06E-01
2.06E-01
2.07E-01
2.07E-01
2.07E-01
2.07E-01
2.07E-01
2.07E-01
2.07E-01
2.07E-01
2.07E-01
2.08E-01
2.08E-01
2.08E-01
2.08E-01
2.08E-01
2.08E-01
2.09E-01
2.09E-01
2.09E-01
2.09E-01
2.09E-01
2.09E-01
2.09E-01
2.09E-01
31762
45023
22915
35000
15718
20862
38159
42977
9870
1412
3262
30740
30311
33219
40445
6583
31270
58503
53299
60218
50112
38131
68234
28470
1190
23620
31759
37669
53207
34948
38394
47384
7825
6320
33629
38025
47708
53277
28932
8873
20360
59956
21788
64684
25384
18590
36376
39293
57038
38567
28637
44458
18481
16409
52789
63130
2507
58513
13173
66301
14509
18706
19546
31323
41174
59503
32761
33611
11341
47297
49987
10241
65353
15839
67827
53496
10042
6219
16121
17212
32109
9972
28671
38412
44234
40924
29671
32260
3102
13248
53853
16756
51222
43901
32785
33757
34464
66930
27522
25695
15600
9207
22978
62808
12669
33820
31782
49377
5735
23746
21962
46163
7269
6945
19777
27660
58495
65557
40407
57526
60135
41604
65059
61416
16423
30930
391
7280
28946
45149
44261
31587
38386
68061
3407
30598
4467
35894
35433
40082
14344
30165
51421
19783
38208
43157
49200
22721
24172
10549
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
83445
7709
79954
84332
56658
339201
79085
64763
57035
90313
391192
7803
10345
9904
53822
80149
25949
114984
26121
84619
4647
3054
64801
84448
51119
9048
55116
4928
23601
100129828
80111
80232
9274
79411
55135
23609
5033
747
5870
116496
11252
8318
5976
22862
84876
54480
83604
55328
283518
85026
10311
79230
2823
9852
221184
54149
6453
11188
189
165631
55143
51559
57149
7185
285622
84769
5298
27343
84905
5062
7416
29766
154791
57506
6866
340061
79852
51230
93426
196335
57707
81572
84899
11007
27099
147372
90326
5568
4738
90850
1616
1455
51061
57826
151651
3718
118491
28958
4705
55890
5685
140735
79813
57621
132851
57020
140832
51071
54442
863
57153
51433
9779
9645
7532
10935
6814
90273
51091
81669
3937
59274
161145
5707
7114
146664
4800
55906
81565
55827
89894
1767
283349
57231
989
5621
64762
6500
6248
10766
9205
50485
9986
253827
84632
638
60370
122876
6613
10105
GSG1
ZBTB17
NOL10
DYDC2
TRIM39
ASB16-AS1
SLC25A23
ZNF574
C1orf63
TP53I13
OR2L3
PTP4A1
TRDN
RBM19
FXYD7
ZC3H12A
SYF2
FLYWCH2
PRPF31
ZGPAT
MYO7A
HCFC1
ARV1
ABLIM2
SBDS
ARTN
TMEM39B
NUP98
CLEC5A
C14orf139
C3orf36
WDR26
BCL7C
GLB1L
WRAP53
MKRN2
P4HA1
DAGLA
RAB6A
FAM129A
PACSIN2
CDC45
UPF1
FNDC3A
ORAI1
CHPF2
TMEM47
RNLS
KCNRG
C9orf37
DSCR3
ZNF557
GPM6A
EPM2AIP1
CPNE2
C21orf91
ITSN1
NISCH
AGXT
PARP15
CDCA8
NT5DC3
LYRM1
TRAF1
NBPF22P
MPV17L2
PI4KB
POLL
ZNF341
PAK2
VDAC1
TMOD3
C7orf55
MAVS
TAC3
TMEM173
EPHX3
PHF20
SYCE1
OR56B4
TLDC1
PDRG1
TMTC4
CCDC85B
SND1-IT1
CCBE1
THAP3
PRKACG
NEDD8
ZNF598
DAXX
CSNK1G2
TXNDC11
RAP2C
EFHB
JAK3
TTC18
COA3
NDUFA10
GPRC5C
PSMA4
DYNLL2
EHMT1
ZBTB2
SPATA4
C16orf62
WFDC10A
DERA
KCTD5
CBFA2T3
SLC44A2
ANAPC5
TBC1D5
MICAL2
YWHAG
PRDX3
STXBP3
CEACAM21
SEPSECS
CCNL2
LCP2
MESDC1
TMEM229B
PSMD1
TMSB4X
MGAT5B
NFYA
ZC4H2
NDEL1
DCAF6
TMEM116
DNAH5
RASSF3
SNX14
SEPT7
PRNP
GAREM
SKP1
RSC1A1
TOB2
ZMYM5
SMARCAL1
RCE1
MSRB3
AFAP1L2
BIK
AVPI1
GPHB5
SUMO2
PPIF
+--+-+
-+++-+
+++++++++-+
+-+--+
+-++++
-+--+-+-+-+
+-+?-+
++++-+
-+++-+-+--+-++++
+++++++---++---+
--+?----+-+
-+--++
-----+
+++-++
---+-+
---+-+----+
+-+?-++--++
-+-+-+
---+---+--+
+--?-+---++
+++++-+-+++
+-+--+
-----+
-----+
+-++-+
+----+
++-?++-+-++-+-++
---+-+
++---+
+-+---+--++
+-++-+
---++++++-+
+++-++
-----+
+--+-+
-+++++
++-+++
--++++
-+++-+
+++++++-++-----+
-++-++
+-++++
--++-+
-----+
+-++-+
++--+++-+-+
---++-+-+-+
++-++++++-+
+---+---+++-+++---+++
-++--+
-++--+
++-+++
+-++-+
-+--++++-++
-+--++
-+--++
-+-+++
+--+-+
-----+
-----+
+++--+
-+++++
+--+++
+-+++-----+
-+-----+-------+
+-++-+
-----+
------++--+
+----+
-+-+-+
+-++-+
-++++++--+-+--++
---+-+
-+++++
---+-+
++--++
+-++++
--++++
++++-+
+-+---+--++---++
++++++-+--+
--++-+
+-+--++++-+
+-++--++-++
+++-++
+-+--+
+-+-++
-+-+-+-+-++
+++-++
--++-+
-+-+++-+--+-+++++-?++-+?-+
--+--+
+-++-+
+-++-+----+
+-++++
+-++++--++-+-?-+
-+++----?-+
-+-+++
+-+++++--++
--+--+
++-+-+
++-+++-++-+
+-+---
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
1.256
1.256
1.256
1.255
1.255
1.255
-1.254
-1.254
1.254
1.254
-1.254
-1.254
1.253
1.253
-1.253
1.252
-1.251
-1.251
-1.251
-1.251
1.251
-1.25
-1.25
-1.25
-1.248
1.248
-1.248
-1.248
-1.248
-1.248
1.247
1.246
1.246
1.246
1.245
-1.245
1.245
1.245
1.243
1.243
1.242
-1.242
1.241
-1.24
-1.24
1.239
-1.239
1.238
1.238
-1.238
1.238
1.237
1.237
1.237
-1.236
1.236
1.236
-1.235
1.235
1.235
1.234
-1.234
1.234
1.234
1.234
-1.233
1.232
1.232
1.232
-1.232
-1.232
1.232
-1.232
1.231
1.231
1.231
1.23
-1.229
1.229
1.229
1.229
-1.229
1.228
-1.228
-1.227
1.226
1.226
1.226
1.226
-1.226
-1.226
-1.225
-1.224
1.224
-1.224
-1.223
-1.223
1.223
-1.222
1.221
1.22
1.22
1.22
-1.22
1.219
-1.219
1.218
1.218
1.217
1.217
-1.216
-1.216
1.215
1.215
-1.215
-1.215
-1.214
1.214
-1.213
1.212
1.212
1.212
1.212
-1.212
1.211
1.211
1.21
-1.21
-1.209
-1.209
1.208
1.208
-1.208
1.208
-1.208
-1.207
1.207
-1.206
-1.205
-1.205
-1.204
-1.204
1.204
1.203
1.203
-1.203
1.201
1.201
1.2
-1.198
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.09E-01
2.09E-01
2.09E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.10E-01
2.11E-01
2.11E-01
2.11E-01
2.11E-01
2.11E-01
2.11E-01
2.11E-01
2.11E-01
2.12E-01
2.12E-01
2.12E-01
2.12E-01
2.12E-01
2.12E-01
2.13E-01
2.13E-01
2.13E-01
2.13E-01
2.13E-01
2.13E-01
2.13E-01
2.13E-01
2.14E-01
2.14E-01
2.14E-01
2.14E-01
2.15E-01
2.15E-01
2.15E-01
2.15E-01
2.15E-01
2.16E-01
2.16E-01
2.16E-01
2.16E-01
2.16E-01
2.16E-01
2.16E-01
2.16E-01
2.16E-01
2.16E-01
2.17E-01
2.17E-01
2.17E-01
2.17E-01
2.17E-01
2.17E-01
2.17E-01
2.17E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.18E-01
2.19E-01
2.19E-01
2.19E-01
2.19E-01
2.19E-01
2.19E-01
2.19E-01
2.19E-01
2.20E-01
2.20E-01
2.20E-01
2.20E-01
2.20E-01
2.20E-01
2.20E-01
2.21E-01
2.21E-01
2.21E-01
2.21E-01
2.21E-01
2.21E-01
2.22E-01
2.22E-01
2.22E-01
2.22E-01
2.23E-01
2.23E-01
2.23E-01
2.23E-01
2.23E-01
2.23E-01
2.23E-01
2.24E-01
2.24E-01
2.24E-01
2.24E-01
2.24E-01
2.24E-01
2.24E-01
2.25E-01
2.25E-01
2.25E-01
2.25E-01
2.25E-01
2.25E-01
2.26E-01
2.26E-01
2.26E-01
2.26E-01
2.26E-01
2.26E-01
2.26E-01
2.27E-01
2.27E-01
2.27E-01
2.27E-01
2.27E-01
2.27E-01
2.27E-01
2.27E-01
2.28E-01
2.28E-01
2.28E-01
2.28E-01
2.29E-01
2.29E-01
2.29E-01
2.29E-01
2.29E-01
2.29E-01
2.30E-01
2.30E-01
2.30E-01
2.31E-01
16787
27956
67543
8599
28521
49676
65115
2701
2193
17826
29886
68108
45808
9479
61470
56084
62616
63479
14866
31085
27295
18297
25126
47595
46272
35286
8474
10494
13999
2120
61855
16317
60349
60596
16538
9401
27724
25287
12247
38966
30295
36286
44300
28094
30307
13497
48972
25863
48924
58147
7412
21377
22059
55330
47282
15231
40417
64755
44950
68195
10285
57195
25057
4600
8045
8617
64456
13141
36251
17110
23833
38664
39783
5768
16292
25125
51734
58403
8559
27397
25547
22557
22569
813
33228
24370
63768
27652
57689
59171
59348
5844
50030
57848
55366
21711
44772
53954
13573
49397
40909
1445
47150
36116
49177
3120
14089
14688
45085
18831
63029
62825
32933
11287
64249
61606
1062
38109
48203
49312
63016
47592
4312
11650
27432
44471
11749
29028
45936
37171
37589
52715
10152
8016
18760
24811
61519
4835
60342
38443
32830
1599
38170
52156
29528
66321
5268
23327
22685
20380
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
342125
51599
127262
60682
79913
247
79178
10558
84539
65244
85019
10327
91120
150159
56142
51704
5347
4719
9015
55100
9535
79567
221302
79922
55204
84866
160760
23170
57614
27128
66008
23325
23122
7633
79147
135656
9856
165721
5770
90507
54458
6241
64651
4772
9265
6870
166824
5510
5688
84987
375
93210
80119
4935
8347
84461
64426
28952
11334
79683
84191
100129828
84304
6788
9898
5827
201292
6391
2529
9208
55075
404266
5370
2549
9546
2072
25861
83892
8747
10205
55181
220064
54583
51651
5393
3156
51626
6602
9731
54778
116842
5869
51660
114991
1022
55702
199857
11149
4239
26160
3091
10126
6171
50624
23013
79661
57546
8314
5962
1755
4594
51738
10534
5957
165829
221035
5481
9938
54469
7988
55585
84775
2782
57103
10160
2843
27185
8912
138311
55668
134145
284086
9208
6461
81926
9686
5165
9002
64747
2304
78988
162966
28989
29844
138429
10263
91452
5498
56967
79706
TMC3
LSR
TPRG1L
SMAP1
ACTR5
ALOX15B
THTPA
SPTLC1
MCHR2
SPATS2
TMEM241
AKR1A1
ZNF682
SLC9B1
PCDHA6
GPRC5B
PLK1
NDUFS1
TAF1A
WDR70
GMFG
FAM65A
ZUFSP
MRM1
GOLPH3L
TMEM25
PPTC7
TTLL12
KIAA1468
CYTH4
TRAK2
KIAA1033
CLASP2
ZNF79
FKRP
DPCR1
KIAA0319
DNAJB8
PTPN1
SCRN2
PRR13
RRM2
CSRNP1
NFATC1
CYTH3
TACR3
RASSF6
PPP1R7
PSMA7
COX14
ARF1
PGAP3
PIF1
GPR143
HIST1H2BC
NEURL4
SUDS3
CCDC22
TUSC2
ZDHHC14
FAM96A
KRT17
NUDT22
STK3
UBAP2L
PXMP2
TRIM65
SDHC
FUT7
LRRFIP1
UACA
HOXB-AS3
PMCHL2
GAB1
APBA3
ERCC4
DFNB31
KCTD10
ADAM21
MPZL2
SMG8
ORAOV1
EGLN1
PTRH2
EXOSC9
HMGCR
DYNC2LI1
SMARCD1
CEP104
RNF111
LEAP2
RAB5B
MPC1
ZNF618
CDK7
CCDC94
ALG14
BVES
MFAP4
IFT172
HIF1A
DNAL4
RPL41
CUZD1
SPEN
NEIL1
PDP2
BAP1
RDX
DMBT1
MUT
GHRL
SSSCA1
RCVRN
GPR156
REEP3
PPID
ARHGAP25
ZFAND6
ZNF212
UBE2Q1
ZNF607
GNB1
C12orf5
FARP1
GPR20
DISC1
CACNA1H
FAM69B
GPATCH2L
FAM173B
NEK8
LRRFIP1
SHB
ABHD17A
VGLL4
PDK3
F2RL3
MFSD1
FOXE1
MRP63
ZNF600
NTMT1
TFPT
PIP5KL1
CDK2AP2
ACBD5
PPOX
C14orf132
PRKRIP1
-++--+
+----+
++---+
-----+--?-+
+-++-+
++++-+
+-++-+
--+-++
-+++++
--+?-+++--+
--+-+---+-+-++++
-+++--+-?++
+-++-+
--+--+
---+-+
+-++++----+
+-+---+-+-+
--+--+
---+-+
-++-++
---+-+
+-+--+----++-+++-+--+-+--+-+----+-++
-+++++
--+--+--+++
++---+
-+++++
++++-+-+-++
+---++
+--+-+
+----+
-++-++++--+
-+-+++
----++
+--+++
+-+++++--++
+++--+
++-+-+
+-+++-+-?-+
--+++--++-+
--+--+
---+-+
--++++---++
+++--+
+-+----+--+
---+++
-----+
-++-++
+++--+
+++--+
+---++
-+--+++-+++++--++---+
---++++--++
+-++-++-+-+
--+--+
+-++-----++
+-+--+
--+--+
--++-+-+--+
--+++-+---+
++---+
+-++++
+----++-+++--+-+
--++-+
+-+--+
+--+-+
-++---++++---+-+
+----+
+-+++--+-++
+--+++
+---++----+
-+-+++
++--+-+---+
--+?--+--++
-+-++--+------++-+?++
+--+-+
--+--+++-+--+?-+
+-++-+--+-+
-----+
--+--+
+----+
+-++---++++
+++-++
-+--++
-+-+-+
++-?---++-+
--++--+---+
+++--+
-++?++
+-+++++---+
-++?-+
++-+++
+-++-++-+++
-++--+++-++
+--+++
-+-+-+
++--+++---+
+-+?-+
++-+++---+----++
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
1.198
-1.198
1.197
-1.197
-1.197
1.197
1.197
1.197
-1.196
1.196
-1.196
1.196
-1.195
-1.195
1.194
-1.194
1.194
1.194
-1.192
-1.192
1.191
-1.19
-1.19
-1.19
-1.19
-1.189
1.189
-1.188
-1.188
-1.187
1.187
-1.187
-1.186
-1.186
1.186
1.185
-1.185
1.184
1.184
1.184
1.183
1.182
1.182
-1.182
-1.181
1.181
1.181
1.181
1.18
1.18
1.179
1.178
1.178
1.176
1.176
-1.175
-1.175
1.175
-1.174
-1.174
1.174
1.174
1.173
1.173
-1.173
-1.173
-1.171
1.171
1.171
1.17
1.17
-1.17
1.17
1.17
-1.17
-1.169
1.169
-1.169
1.169
-1.169
-1.168
-1.167
1.167
-1.167
-1.166
1.166
-1.166
-1.165
1.165
1.165
-1.164
1.164
-1.164
-1.164
1.163
-1.163
-1.162
1.162
1.162
-1.161
-1.16
1.16
1.16
-1.16
-1.159
1.159
-1.159
1.158
-1.158
-1.158
-1.158
-1.157
-1.157
1.156
1.155
-1.155
1.155
1.155
-1.155
-1.154
-1.154
-1.153
1.153
-1.153
1.152
1.151
1.15
-1.15
-1.15
1.15
-1.15
-1.15
1.149
1.148
1.148
1.148
1.148
1.147
1.147
1.147
-1.146
1.146
1.145
1.146
-1.145
1.145
1.145
1.144
-1.143
-1.143
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.31E-01
2.31E-01
2.31E-01
2.31E-01
2.31E-01
2.31E-01
2.31E-01
2.31E-01
2.32E-01
2.32E-01
2.32E-01
2.32E-01
2.32E-01
2.32E-01
2.32E-01
2.33E-01
2.33E-01
2.33E-01
2.33E-01
2.33E-01
2.34E-01
2.34E-01
2.34E-01
2.34E-01
2.34E-01
2.34E-01
2.35E-01
2.35E-01
2.35E-01
2.35E-01
2.35E-01
2.35E-01
2.36E-01
2.36E-01
2.36E-01
2.36E-01
2.36E-01
2.36E-01
2.36E-01
2.36E-01
2.37E-01
2.37E-01
2.37E-01
2.37E-01
2.38E-01
2.38E-01
2.38E-01
2.38E-01
2.38E-01
2.38E-01
2.38E-01
2.39E-01
2.39E-01
2.40E-01
2.40E-01
2.40E-01
2.40E-01
2.40E-01
2.40E-01
2.40E-01
2.40E-01
2.41E-01
2.41E-01
2.41E-01
2.41E-01
2.41E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.42E-01
2.43E-01
2.43E-01
2.43E-01
2.43E-01
2.43E-01
2.44E-01
2.44E-01
2.44E-01
2.44E-01
2.44E-01
2.44E-01
2.44E-01
2.44E-01
2.45E-01
2.45E-01
2.45E-01
2.45E-01
2.45E-01
2.45E-01
2.45E-01
2.46E-01
2.46E-01
2.46E-01
2.46E-01
2.46E-01
2.46E-01
2.46E-01
2.46E-01
2.47E-01
2.47E-01
2.47E-01
2.47E-01
2.47E-01
2.47E-01
2.48E-01
2.48E-01
2.48E-01
2.48E-01
2.48E-01
2.48E-01
2.48E-01
2.49E-01
2.49E-01
2.49E-01
2.49E-01
2.49E-01
2.50E-01
2.50E-01
2.50E-01
2.50E-01
2.50E-01
2.50E-01
2.50E-01
2.51E-01
2.51E-01
2.51E-01
2.51E-01
2.51E-01
2.51E-01
2.52E-01
2.52E-01
2.52E-01
2.52E-01
2.52E-01
2.52E-01
2.52E-01
2.52E-01
2.52E-01
2.53E-01
2.53E-01
2.53E-01
5176
14830
49561
342
29580
32131
33147
16541
25041
19691
38007
2686
8200
13338
9825
20795
24828
12073
14864
50654
45371
28176
12141
7339
40628
60109
17732
23056
42524
62759
67175
3696
33430
22279
182
19697
23924
56681
56135
18534
9197
5076
68166
24754
28146
60682
18115
33542
55389
20382
41709
46723
33684
7687
18973
59039
13030
17342
4899
50975
60530
17371
40261
24639
47380
14771
7723
19573
28129
40421
14836
47824
47179
57191
40618
11415
54182
8520
64860
63849
23730
5930
32712
64199
8518
29916
33288
40632
29375
51979
48158
58364
59496
62936
13114
63853
67697
48260
10793
6053
30389
33971
42308
11514
15673
55828
2967
32042
46746
40700
4121
66250
31652
2864
25102
9964
55312
62402
59325
65174
6035
59285
47451
35172
4559
13734
23540
46726
37902
18492
12980
10231
7453
11394
4837
3163
34834
66909
63735
60274
67369
985
30144
40274
55540
33509
46906
34535
6847
35876
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
4778
84733
23647
114789
92305
255520
7769
26145
6640
84636
254531
149428
55175
54932
79623
26515
339779
5021
83983
143630
84886
5590
29940
83700
283521
9968
84376
64806
51205
3798
3975
100129828
2567
23074
1111
2039
149076
90441
64410
28991
51188
10347
55762
8503
4281
540
23641
115273
11311
3226
286451
4296
157777
11014
54979
6123
55924
3092
79139
3205
26996
653140
90199
55033
25824
58513
360023
4957
23207
6534
1490
9897
23373
1138
25939
55729
8479
149345
126969
23351
84079
9368
6118
3275
129642
7555
23098
93611
29882
54936
55216
4702
4782
8639
8893
221955
5500
22944
124056
83692
349075
2063
10150
1910
150763
55280
3055
10435
284358
65009
90957
1783
55030
83890
5090
1891
8692
5891
7461
55704
1056
25911
284114
9797
339390
83874
10526
4717
80818
4665
290
286128
78994
3426
9270
9906
3632
56674
57727
84126
10233
4191
89910
23162
201799
5630
6095
54800
25807
54165
NFE2
CBX2
ARFIP2
SLC25A25
TMEM129
ELMOD2
ZNF226
IRF2BP1
SNTA1
GPR174
LPCAT4
BNIPL
KLHL11
EXD3
GALNT14
TIMM10B
C2orf53
OXTR
TSSK6
UBQLNL
C1orf198
PRKCZ
DSE
JAM3
AK124707
MED12
HOOK3
IL25
ACP6
KIF5A
LHX1
FLJ37078
GABRG3
UHRF1BP1L
CHEK1
DMTN
ZNF362
ZNF622
KLHL25
COMMD5
SS18L2
ABCA7
ZNF701
PIK3R3
MID1
ATP7B
LDOC1
RAB42
VPS45
HOXC10
YIPF6
MAP3K11
MCMDC2
KDELR2
HRASLS2
RPL3L
FAM212B
HIP1
DERL1
HOXA9
GPR160
FAM228A
WFDC8
FKBP14
PRDX5
EPS15L1
ZBTB41
ODF2
PLEKHM2
SLC6A7
CTGF
KIAA0196
CRTC1
CHRNA5
SAMHD1
ATF7IP
HIRIP3
SHISA4
SLC44A3
KHNYN
ANKRD27
SLC9A3R1
RPA2
PRMT2
MBOAT2
CNBP
SARM1
FBXO44
ANAPC2
ADPRHL2
C11orf57
NDUFA8
NFIC
AOC3
EIF2B5
DAGLB
PPP1CB
KIN
NOXO1
CD99L2
ZNF713
NR2F6
MBNL2
EDNRB
GPAT2
CWF19L1
HCK
CDC42EP2
MAMSTR
NDRG4
DHX57
DYNC1LI2
FBXO34
SPATA9
PBX3
ECH1
HYAL2
MOK
CLIP2
CCDC88A
CEL
DPCD
TMEM102
TATDN2
CLEC4G
TBC1D10A
IPO8
NDUFC1
ZNF436
NAB2
ANPEP
ZFP41
PRR14
CFI
ITGB1BP1
SLC35E2
INPP5A
TMEM9B
NCOA5
ATRIP
LRRC23
MDH2
UBE3B
MAPK8IP3
TMEM154
PRPH
RORA
KLHL24
RHBDD3
DCUN1D1
++-++----++
+-++++
-----+
-+---+
+-++-+
++--+-+----+-+-+
++-++--++++
+-+--+
+-+-++
+----+-+---+-++-+++-+
+-+----++++
-----+
++--+-+++-+
+-+--+
++--++++-++
++--++
+-++++++-++
-----+
-++?++
--+-++
+-+?++
++++-+
+++----++-++-++-+++-+
--+--+
--+---+-+-+
---++-++--+
+-+---+-+++
--+-++
+-+--+
+---++++++++--++
++++-+
++-++++++-+
+++--+
--++---+--+
++--++
-++--+
+++--+
+----+
--+----++++
+-----++-++
-----+
-+-++++--++
--++-----++
-+---+
-++--+
+---++
---+-+
-++-++
+----+
-----+
+++-+---+++
++--+-----++-?-+-++-+
++---+
-----+
-++?+++++++-++-+
++---+---++
-+---+
-+++-+
--++----+-+
--+----+-------+
-----+
+-+++++--+-+++++
++--+++-++-----+
+-++---++++
--+----++-+
+-+--+
-++---+--++
++-+++
-----+
+---++
+-++++
--+-++--+++
-+-+++
+++--+
+----+--+++
+-+--+
-+-+-+
++-++++-+++
-----+
++-+++
-----+
+--+++-++-+----+
-+---+
+++--+
+-++-+
++---+
--++-+++--+
+---++
-+++++
+--++++-?-+
-----+
----++
---+-+
+-++-+
++---+
++++-+
+--+-+
---++--+--+
+--+-+
+++++-
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.143
-1.143
1.143
-1.143
-1.142
1.142
-1.142
-1.142
-1.142
-1.141
1.14
-1.14
1.14
-1.14
-1.139
1.139
1.139
-1.138
1.138
-1.137
1.136
1.136
1.135
-1.134
1.134
1.133
1.133
1.133
-1.133
1.133
1.133
1.132
1.132
1.131
-1.131
1.13
1.13
-1.129
-1.129
1.129
-1.128
-1.128
-1.127
1.127
1.126
1.126
1.126
1.125
1.125
1.125
1.125
1.125
1.124
-1.124
-1.124
1.124
1.124
1.123
-1.122
-1.122
1.122
-1.121
1.121
-1.12
1.12
1.119
-1.119
-1.119
-1.119
1.118
1.118
-1.118
1.118
-1.117
-1.117
1.117
-1.116
-1.116
-1.116
1.116
1.116
1.115
-1.114
-1.114
1.112
1.112
-1.112
1.112
-1.112
1.111
-1.111
-1.111
-1.11
-1.11
-1.109
-1.109
-1.109
-1.108
1.108
-1.107
1.107
-1.107
-1.107
1.106
-1.106
-1.106
1.105
-1.105
-1.105
1.105
-1.105
1.105
1.104
-1.104
1.104
1.103
1.103
-1.103
1.103
1.103
1.103
1.103
1.102
-1.102
1.102
-1.101
-1.101
1.1
1.1
-1.099
1.099
1.099
1.099
-1.099
1.098
1.098
1.098
1.098
-1.097
-1.097
-1.097
-1.097
1.097
1.095
1.096
1.094
-1.094
-1.094
1.093
-1.093
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.53E-01
2.53E-01
2.53E-01
2.53E-01
2.53E-01
2.53E-01
2.53E-01
2.54E-01
2.54E-01
2.54E-01
2.54E-01
2.54E-01
2.54E-01
2.55E-01
2.55E-01
2.55E-01
2.55E-01
2.55E-01
2.55E-01
2.56E-01
2.56E-01
2.56E-01
2.57E-01
2.57E-01
2.57E-01
2.57E-01
2.57E-01
2.57E-01
2.57E-01
2.57E-01
2.57E-01
2.58E-01
2.58E-01
2.58E-01
2.58E-01
2.59E-01
2.59E-01
2.59E-01
2.59E-01
2.59E-01
2.59E-01
2.59E-01
2.60E-01
2.60E-01
2.60E-01
2.60E-01
2.60E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.61E-01
2.62E-01
2.62E-01
2.62E-01
2.62E-01
2.62E-01
2.63E-01
2.63E-01
2.63E-01
2.63E-01
2.63E-01
2.63E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.64E-01
2.65E-01
2.65E-01
2.65E-01
2.65E-01
2.66E-01
2.66E-01
2.66E-01
2.66E-01
2.66E-01
2.66E-01
2.67E-01
2.67E-01
2.67E-01
2.67E-01
2.67E-01
2.68E-01
2.68E-01
2.68E-01
2.68E-01
2.68E-01
2.68E-01
2.68E-01
2.68E-01
2.69E-01
2.69E-01
2.69E-01
2.69E-01
2.69E-01
2.69E-01
2.69E-01
2.69E-01
2.69E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.70E-01
2.71E-01
2.71E-01
2.71E-01
2.71E-01
2.71E-01
2.71E-01
2.72E-01
2.72E-01
2.72E-01
2.72E-01
2.72E-01
2.72E-01
2.72E-01
2.72E-01
2.72E-01
2.73E-01
2.73E-01
2.73E-01
2.73E-01
2.73E-01
2.73E-01
2.73E-01
2.74E-01
2.74E-01
2.74E-01
2.74E-01
2.75E-01
18199
46527
26557
65626
68378
24606
41688
55993
3560
48323
33930
59791
39263
49939
63180
50613
54244
63458
27195
36093
57037
51144
21594
17254
54707
29030
22894
9739
61831
5442
2191
47959
58558
56651
50464
40801
45639
52846
45280
36406
36026
1488
4061
30621
30669
62693
27662
58548
7026
48897
20968
32327
2869
26081
49322
66777
15557
46144
48891
12217
55151
25730
3370
67568
23455
43727
58897
65847
32352
65587
68517
1730
50615
16248
49773
53461
20189
35008
25583
53845
31751
47419
29289
17661
41854
56731
41224
3400
26227
57136
32561
38921
26545
30705
60988
16467
8210
35618
67688
15634
59954
34715
50392
20295
47714
9400
50163
1290
12460
9745
21060
11317
58668
49354
35118
12909
58681
14019
53881
1720
48909
22530
66270
12891
47418
61772
20097
28910
22800
6126
13440
22664
40021
44265
36688
39106
53752
42998
15411
63002
899
14791
15565
38746
62494
46781
3556
17464
27054
49718
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
6535
6659
6258
55187
130013
493856
83758
51759
55684
11272
2050
65260
1825
11155
5927
93474
4904
3704
79717
9370
151556
57535
5654
23101
29124
1280
10301
123803
10882
29967
51333
23432
285971
9684
7485
5075
51209
55266
8540
112483
57561
63935
79844
100129828
81833
7324
11166
5977
9683
9937
7276
64645
7458
80759
2319
114798
152302
374666
200958
54965
9901
65992
389763
81577
123606
79823
255919
29057
81566
8367
63934
7508
84902
741
5723
175
11140
5992
9663
8574
79134
55869
6897
10902
27349
833
2224
838
9479
84219
121268
6883
126295
3354
10425
64222
9753
113178
6046
10393
6487
55862
358
10019
23405
23562
2832
24138
2921
27238
56616
57459
9757
3662
11321
79903
55705
56886
6667
100129828
10656
151056
81846
25801
90525
81027
100129828
6547
84870
152518
440278
10951
79754
51135
1198
79691
152185
3297
5024
5603
899
64976
23300
84922
56052
22908
55715
1907
5167
91012
SLC6A8
SOX4
RXRG
VPS13D
ACMSD
CISD2
RBP5
C9orf78
RABL6
PRR4
EPHB4
SELRC1
DSC3
LDB3
KDM5A
ZNF670
YBX1
ITPA
PPCS
ADIPOQ
GPR155
KIAA1324
HTRA1
MCF2L2
LGALS13
COL2A1
DLEU1
NTAN1
C1QL1
LRP12
ZNF771
GPR161
ZNF775
LRRC14
WRB
PAX1
RAB9B
TMEM19
AGPS
SAT2
ARRDC3
PCIF1
ZDHHC11
ELYS
SPACA1
UBE2E1
SOX21
DPF2
N4BP1
DCLRE1A
TTR
HIAT1
EIF4H
KHDC1
FLOT2
SLITRK1
CIDECP
WASH2P
MUC20
PIGX
SRGAP3
DDRGK1
SPATA31D1
GFOD2
NIPA1
CAMKMT
CNEP1R1
FAM156A
CSRNP2
HIST1H4E
ZNF667
XPC
CEP89
ZNHIT2
PSPH
AGA
CDC37
RFX4
LPIN2
AKR7A2
TMEM185B
HDAC8
TARS
BRD8
MCAT
CARS
FDPS
CASP5
MAPK8IP1
WDR24
RHEBL1
TAF12
ZNF57
HTR1E
ARIH2
TOR3A
ZSCAN12
SCAMP4
BRD2
ANAPC10
ST3GAL3
ECHDC1
AQP1
SH2B3
DICER1
CLDN14
NPBWR2
IFIT5
CXCL3
GPKOW
DIABLO
GATAD2B
WBP7
IRF4
GPN1
NAA60
IPO9
UGGT1
SP1
NDUFS7
KHDRBS3
PLB1
SBF2
GCA
SHF
TUBB1
FKBP7
SLC8A3
RSPO3
NFXL1
CATSPER2P1
CBX1
ASB13
IRAK4
CLK3
QTRTD1
SPICE1
HSF1
P2RX3
MAPK13
CCNF
MRPL40
ATMIN
FIZ1
ALG1
SACM1L
DOK4
EDN2
ENPP1
CERS5
++-++--+--+
+-++++
+----+
--+--+
+-++--+++++
++-++++---+
+--+++-+--+
-+-+++
-+--++
++--++
-+--++
++--++
++-+--+-+-+
+-++-+
+-+-++
+++++-+-?-+++-++--+-+----+--+++
+--+-++-++----++
+-++----++++-+++
-----+
+----+
+-++--++-++
-++?-+
-++----++++
-+-+-+
--+---+-+-+
+++-++
----+++++++
--++-+
+++--+
-----+
++---+--++++--++
+-+--+
-+-+-+
-+-+++
+-+-++
++-?++
+++-++
++--+--++-+
+-+--+---++
-+-+-+
+++--+
++-+++-+--+
+--+-+-+--+
--++++
++-+-+
-++---+-+++---++
-+++---++---++-+
-----+
----++
++--++
+-++----+-+
+-+-++
---+++
-+++-+
--+--+
--+--+
-+++-+
++-+-+
+++-++--+++
-----+
-+++++
--++++
--+---+-+++
++--++
---+-+
--++-++++-+
-+---+
+-+--+
+-+----++-+-++++
+--+-+
+-+------+---+++
+-++--++++++++----+++
++---+
++---+
+-++-+
---+++
+-++-+
++-+-+
-+-+++
-++-++
--++-+
---+++
+-+--+
+-+--+-++-+-++++
++--+-+---+
+---+++++-+
+-+------++
--+--+
---+-+
+-+++++--++
--+?-++--+-+-+++
+++--+
-+---+
----++
-----+
+--+---+--+
-----+
+-+?---+--+
-+--++
-+++++++?++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
1.092
-1.092
1.092
-1.092
-1.09
-1.09
1.09
1.09
1.088
-1.089
1.088
1.088
1.088
1.087
1.087
1.087
-1.087
-1.087
1.086
1.086
1.085
-1.085
1.084
-1.084
-1.084
1.084
-1.083
1.081
1.081
-1.081
-1.081
1.081
-1.08
-1.079
1.079
1.078
-1.077
-1.077
1.077
1.077
-1.076
1.076
1.076
-1.075
1.074
-1.074
1.074
-1.074
-1.073
-1.073
1.073
1.073
1.072
1.072
1.072
1.071
1.071
1.071
1.071
-1.069
1.069
1.069
1.069
1.069
1.068
-1.068
1.068
1.068
1.067
-1.067
-1.067
1.066
-1.066
-1.066
-1.065
-1.065
-1.065
1.064
-1.063
-1.063
1.062
1.062
-1.061
-1.061
-1.06
1.06
1.06
1.059
1.06
-1.059
1.059
1.059
-1.058
1.058
1.058
-1.057
-1.057
1.057
1.057
1.057
-1.057
-1.056
1.056
-1.056
-1.056
-1.055
1.055
1.054
1.053
1.053
1.052
-1.052
1.051
1.051
1.051
1.05
1.05
1.05
1.049
1.049
1.049
1.049
-1.049
1.049
1.048
1.048
-1.048
1.048
1.047
-1.047
-1.047
-1.047
-1.047
1.047
1.047
-1.047
-1.047
1.046
1.046
1.045
-1.045
-1.045
-1.045
-1.044
-1.043
-1.043
-1.043
1.043
-1.043
1.043
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2.75E-01
2.75E-01
2.75E-01
2.75E-01
2.76E-01
2.76E-01
2.76E-01
2.76E-01
2.76E-01
2.76E-01
2.77E-01
2.77E-01
2.77E-01
2.77E-01
2.77E-01
2.77E-01
2.77E-01
2.77E-01
2.77E-01
2.77E-01
2.78E-01
2.78E-01
2.78E-01
2.78E-01
2.78E-01
2.79E-01
2.79E-01
2.80E-01
2.80E-01
2.80E-01
2.80E-01
2.80E-01
2.80E-01
2.80E-01
2.81E-01
2.81E-01
2.81E-01
2.82E-01
2.82E-01
2.82E-01
2.82E-01
2.82E-01
2.82E-01
2.83E-01
2.83E-01
2.83E-01
2.83E-01
2.83E-01
2.83E-01
2.83E-01
2.83E-01
2.83E-01
2.84E-01
2.84E-01
2.84E-01
2.84E-01
2.84E-01
2.84E-01
2.84E-01
2.85E-01
2.85E-01
2.85E-01
2.85E-01
2.85E-01
2.85E-01
2.85E-01
2.85E-01
2.85E-01
2.86E-01
2.86E-01
2.86E-01
2.86E-01
2.87E-01
2.87E-01
2.87E-01
2.87E-01
2.87E-01
2.87E-01
2.88E-01
2.88E-01
2.88E-01
2.88E-01
2.89E-01
2.89E-01
2.89E-01
2.89E-01
2.89E-01
2.89E-01
2.89E-01
2.90E-01
2.90E-01
2.90E-01
2.90E-01
2.90E-01
2.90E-01
2.90E-01
2.91E-01
2.91E-01
2.91E-01
2.91E-01
2.91E-01
2.91E-01
2.91E-01
2.91E-01
2.91E-01
2.91E-01
2.92E-01
2.92E-01
2.92E-01
2.92E-01
2.93E-01
2.93E-01
2.93E-01
2.93E-01
2.93E-01
2.94E-01
2.94E-01
2.94E-01
2.94E-01
2.94E-01
2.94E-01
2.94E-01
2.94E-01
2.94E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.95E-01
2.96E-01
2.96E-01
2.96E-01
2.96E-01
2.96E-01
2.96E-01
2.97E-01
2.97E-01
2.97E-01
2.97E-01
2.97E-01
2.97E-01
49471
1891
59840
22357
60838
67490
10833
60761
16374
44472
48953
15461
28531
35150
35446
58237
45243
19611
44846
42264
51150
60703
41393
41610
65150
6844
51940
67183
19445
23916
12809
19939
2603
39995
26542
37169
25084
42534
53392
3361
27572
10039
63380
7316
19262
51634
14447
9659
29071
62390
28024
65939
12268
47186
54794
57648
31222
7676
52499
55531
45133
9391
48624
17991
51124
42789
6737
48771
38954
44084
6475
34786
55795
29336
34979
65551
25822
55990
16689
61654
45290
48225
45803
23763
52222
6645
22202
25514
36493
39795
46101
54529
2710
8338
49209
60203
2893
28602
32447
50003
2988
45651
67619
11899
53682
5096
44364
8964
59764
16944
5083
48450
17852
24960
62949
31675
40966
54045
10210
25074
65074
30758
54384
58629
55805
48710
17578
48870
58475
67787
45178
6926
17832
14322
5027
14859
15601
26955
31557
44794
60550
8068
61476
26788
37293
49138
46248
26556
59584
8998
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
79797
1263
51399
26064
134553
55388
23309
79833
148581
51272
2107
57107
6184
64089
152206
79701
4051
9554
64768
26173
22883
653252
135114
3625
79177
83941
255057
867
138241
202333
11024
23499
80212
10982
9104
1627
8570
5792
23214
8428
109
29116
79818
158401
29062
65125
51058
27123
29894
84289
151647
57679
54536
6734
29893
5345
2800
55320
6939
3909
64844
1962
18
118490
57515
57615
3642
51103
10972
30818
7490
3381
54820
221823
51004
55599
79742
3190
22861
51588
80167
9520
7405
2177
9559
3383
2596
23492
2066
4900
83942
246243
79228
23787
91419
490
129138
27197
9636
128853
54852
55207
285343
6905
27113
7517
1164
146705
83714
153657
11077
90378
10400
83551
7786
10206
2935
1947
9100
345757
57106
2146
79689
5757
1849
84912
8635
5426
10021
2865
642946
253260
81573
6293
4133
64641
8395
3291
11319
131965
54629
509
801
55262
10612
5908
9039
5479
79829
124401
ZNF408
PLK3
TRAPPC4
RAI14
C5orf24
MCM10
SIN3B
GEMIN6
UBE2U
BET1L
ETF1
PDSS2
RPN1
SNX16
CCDC13
OGFOD3
CYP4F3
SEC22B
IPPK
INTS1
CLSTN1
TIMM23B
HINT3
INHBB
ZNF576
TM2D1
C19orf26
CBL
C9orf85
CMYA5
LILRA1
MACF1
CCDC92
MAPRE2
RGN
DBN1
KHSRP
PTPRF
XPO6
STK24
ADCY3
MYLIP
ZNF552
C9orf84
WDR91
WNK1
ZNF691
DKK2
CPSF1
ING5
FAM19A4
ALS2
EXOC6
SRPR
PSMC3IP
SERPINF2
GOLGA1
MIS18BP1
TCF15
LAMA3
MARCH7
EHHADH
ABAT
MSS51
SERINC1
ZNF492
INSM1
NDUFAF1
TMED10
KCNIP3
WT1
IBSP
NDE1
PRPS1L1
COQ6
RNPC3
CXorf36
HNRNPK
NLRP1
PIAS4
C4orf29
NPEPPS
UVRAG
FANCD2
VPS26A
ICAM1
GAP43
CBX7
ERBB4
NRGN
TSSK1B
RNASEH1
THOC6
MTCH1
XRCC6BP1
ATP2B1
ANKRD54
GPR82
ISG15
DUSP15
PAQR5
ARL8B
TCAIM
TBCE
BBC3
XRCC3
CKS2
ENTHD2
NRIP2
TTC23L
HSF2BP
SAMD1
PEMT
TAAR8
MAP3K12
TRIM13
GSPT1
EFNB1
USP10
FAM174A
NAT14
EZH2
STEAP4
PTMA
DUSP7
SLC35B4
RNASET2
POLE
HCN4
FFAR3
FLVCR1-AS1
RICTOR
ANKRD13C
VPS52
MAP2
EBF2
PIP5K1B
HSD11B2
ECD
METTL6
FAM63B
ATP5C1
CALM1
C7orf43
TRIM3
RAP1B
UBA3
PPIB
NAA40
ANKS3
-+-+-+
-----+
-+-+++------+---+--------+
--++++
-+-+++
-+---+
--++-++--+--+-++
--+---+--++
-++-++
+-+--+
+-++--+--++
++---+
++-?++
----+--++++
--++++
--++-+
--++-+
+---++
--+--+
---+++++--+
-+++-+
++--+++--+++-++++++-+
-+-+-+
-+--+++--++
+-+--+
++-+++
+---++
--+--+
+-++-+++++--+--+
++-++-+-+-+
-++-++
-+--++
---+-+
++++++++--+
-++-+-+---+
+--+++
--+?-+
+---++
+-++--+--++
+-+--+
+-+-----?-+
+-++-+
--+--+
+-++-++-+-+++----+--+
--+++-----+
+++++-+-+-+
++---+
---+--+-+-+
--++--++-++
-+++++
+++---+-+++
+----+-+--+----+----+-+----++++
++---+
+++--+
-++++++-++---+-+
-+---+
---+-+
--++-+
+-++++-+--+++--+
+-+?+++++--+-+++
++-+++
+-++-+
+--?-+
--++-+
+--+-+
----++
---++++-?-+
--+---+-+++
-+-+++++--+
---+-+
+---++
+-+--+
+++--+
++-+++++--++++-++++---++-+
+--+-+-+----++-+
-+++-+
+----+
+++--+--+++
---+++
++--++
--+--+
+-+--+---+-+-+++
-+--++
----+-++++--++-+
---+--+++-+
++++---+++++-+++
--+--+
++++-+
+-++++-++-+
-+++-+
-+-+-+
----++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
1.042
-1.042
-1.042
-1.041
-1.041
-1.041
-1.04
-1.04
1.04
-1.04
-1.038
1.037
1.037
-1.037
1.035
1.035
1.035
-1.035
1.034
1.034
1.034
-1.034
1.033
1.033
1.033
-1.033
1.033
-1.032
-1.032
1.032
1.032
1.032
1.031
1.031
1.031
-1.031
-1.03
1.03
-1.029
1.029
-1.029
-1.029
1.029
1.029
1.028
1.029
-1.028
1.028
-1.028
-1.027
1.026
1.026
-1.026
-1.025
1.025
-1.025
1.024
-1.023
1.023
1.023
-1.023
-1.023
1.023
1.023
1.022
-1.022
1.022
-1.021
-1.02
-1.02
1.019
1.019
1.019
-1.018
1.017
-1.017
1.017
1.017
-1.016
1.016
-1.015
-1.014
-1.014
-1.014
-1.014
1.014
1.013
1.013
1.012
1.012
1.012
-1.012
-1.012
1.012
-1.012
-1.012
1.011
-1.011
1.011
1.011
1.01
1.01
1.01
-1.009
1.009
-1.009
-1.008
1.007
-1.007
1.007
-1.006
-1.006
-1.006
1.005
1.005
1.005
1.004
1.004
1.003
1.003
-1.002
-1.002
1.002
1.002
1.001
-1.001
-1.001
1.001
1.001
0.999
0.999
-0.998
-0.998
0.998
-0.997
-0.996
0.996
0.995
-0.994
0.994
0.994
0.993
0.993
0.992
0.992
0.991
0.991
0.991
0.991
-0.99
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
2.98E-01
2.98E-01
2.98E-01
2.98E-01
2.98E-01
2.98E-01
2.98E-01
2.98E-01
2.98E-01
2.98E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.01E-01
3.02E-01
3.02E-01
3.02E-01
3.02E-01
3.02E-01
3.02E-01
3.02E-01
3.02E-01
3.03E-01
3.03E-01
3.03E-01
3.03E-01
3.03E-01
3.03E-01
3.03E-01
3.03E-01
3.04E-01
3.04E-01
3.04E-01
3.04E-01
3.04E-01
3.04E-01
3.04E-01
3.04E-01
3.04E-01
3.05E-01
3.05E-01
3.05E-01
3.05E-01
3.05E-01
3.06E-01
3.06E-01
3.06E-01
3.06E-01
3.06E-01
3.06E-01
3.06E-01
3.06E-01
3.07E-01
3.07E-01
3.07E-01
3.07E-01
3.07E-01
3.08E-01
3.08E-01
3.08E-01
3.08E-01
3.08E-01
3.09E-01
3.09E-01
3.09E-01
3.09E-01
3.09E-01
3.10E-01
3.10E-01
3.10E-01
3.10E-01
3.11E-01
3.11E-01
3.11E-01
3.11E-01
3.11E-01
3.11E-01
3.11E-01
3.11E-01
3.11E-01
3.11E-01
3.12E-01
3.12E-01
3.12E-01
3.12E-01
3.12E-01
3.12E-01
3.12E-01
3.12E-01
3.12E-01
3.12E-01
3.13E-01
3.13E-01
3.13E-01
3.13E-01
3.13E-01
3.14E-01
3.14E-01
3.14E-01
3.14E-01
3.15E-01
3.15E-01
3.15E-01
3.15E-01
3.15E-01
3.15E-01
3.16E-01
3.16E-01
3.16E-01
3.16E-01
3.16E-01
3.17E-01
3.17E-01
3.17E-01
3.17E-01
3.17E-01
3.17E-01
3.17E-01
3.18E-01
3.18E-01
3.18E-01
3.18E-01
3.19E-01
3.19E-01
3.19E-01
3.19E-01
3.20E-01
3.20E-01
3.20E-01
3.20E-01
3.21E-01
3.21E-01
3.21E-01
3.21E-01
3.21E-01
3.22E-01
3.22E-01
3.22E-01
3.22E-01
68085
56494
66392
15935
66887
65971
41855
56884
50876
31553
36324
27091
46143
16243
65366
16627
51774
34123
48373
30956
62523
41435
58694
10761
54116
20270
50215
55281
35957
46300
58178
58546
21547
63722
3876
5606
62253
21510
62076
8308
19404
21073
67289
45855
42839
49484
50333
54130
12867
1233
28607
49343
24280
48593
4833
52210
25272
38926
31498
3333
17671
10890
40133
50258
37054
56127
58116
44024
18349
42447
26237
1848
48302
42968
39421
17307
62548
63701
65004
36639
37975
39344
61467
65411
62358
18112
59269
15009
6648
49374
5247
51534
24846
15323
40894
21537
66316
16110
47078
15363
18915
29518
64030
12300
40192
4665
22910
52314
6796
27280
30749
44506
34861
59238
67590
19843
55770
46552
57056
33207
9747
37914
39704
23683
38483
65609
64084
11633
51645
38156
50140
24913
45022
23541
29065
24473
44554
68216
103
9919
18875
51919
12777
1541
1052
10213
52122
57364
63343
20593
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
79190
163782
2733
119391
50813
441046
393
663
51142
4898
147339
55558
150383
1376
144100
51550
6499
5394
375298
266812
286053
92292
51133
7180
55857
8655
2683
374872
118813
10120
79154
84830
2054
4635
9861
2879
8034
7314
10285
65122
7903
8131
128861
283711
162494
23760
256471
55205
23054
26232
140460
54920
6764
50484
8490
3786
1439
56478
51663
10148
2960
9583
78986
7528
210
22903
51330
2954
197021
8698
363
253128
51761
29093
284058
118460
26230
2762
79586
9731
347853
8344
64943
2002
201229
10280
9
79905
10101
403323
23236
79759
10978
79862
4811
6301
220001
3960
4664
57799
55588
4952
27299
26092
150
29927
79699
54531
2651
10220
114883
9827
23149
1844
30001
10666
115399
5648
9146
919
9572
1855
7328
535
9802
23180
54464
51315
10273
9900
10911
478
57648
200185
84232
29890
6007
11158
912
401261
29990
115426
9805
10947
100129828
57038
222643
23120
2059
4774
IRX6
KANK4
GLE1
GSTO2
COPS7A
GUSBP5
ARHGAP4
BNIP2
CHCHD2
NRD1
C18orf25
PLXNA3
CDPF1
CPT2
PLEKHA7
CINP
SKIV2L
EXOSC10
CERKL
NAP1L5
NSMCE2
GLYATL1
KCTD3
CRISP2
PLK1S1
DYNLL1
B4GALT1
C19orf35
ZFYVE27
ACTR1B
DHRS11
ADTRP
STX2
MYL4
PSMD6
GPX4
SLC25A16
UBB
SMNDC1
PRAMEF2
ST8SIA4
NPRL3
BPIFA3
UBE2CP4
RHBDL3
PITPNB
MFSD8
ZNF532
NCOA6
FBXO2
ASB7
DUS2L
ST5
RRM2B
RGS5
KCNQ3
CSF2RB
EIF4ENIF1
ZFR
EBI3
GTF2E1
ENTPD4
DUSP26
YY1
ALAD
BTBD3
TNFRSF12A
GSTZ1
LCTL
S1PR4
AQP6
LINC00612
ATP8A2
MRPL22
KANSL1
EXOSC6
TIAM2
GMDS
CHPF
CEP104
TBX10
HIST1H2BE
NT5DC2
ELK1
LYRM9
SIGMAR1
NAT1
TMC7
NUBP2
FLJ20444
PLCB1
ZNF668
CLP1
ZNF669
NID1
SARS
VWCE
LGALS4
NAB1
RAB40C
MED29
OCRL
ADAMDEC1
TOR1AIP1
ADRA2A
SEC61A1
ZYG11B
MIER2
GCNT2
GDF11
OSBPL9
RGP1
FCHO1
DUSP2
ERO1L
CD226
LRRC56
MASP1
HGS
CD247
NR1D1
DVL1
UBE2H
ATP6V0A1
DAZAP2
RFTN1
XRN1
KRCC1
STUB1
SV2A
UTS2
ATP1A3
KIAA1522
KRTCAP2
MAF1
RBM15B
RHD
RABL2B
CD1D
FLJ38717
PILRB
UHRF2
SCRN1
AP3M2
EXLM1
RARS2
UNC5CL
ATP10B
EPS8
NFIA
+-+-++
---?-+
---+++
-----+
---?-+
++++--+--++
+-+----++++
+++++--+-+++--++
----++
--++++
--++-+
--++-++---+
---+-+
--+--+
+--+-----++
+-+?+--++-+
++++-+
+--+-+++++--+--+-+?++
+---------+
----++
+--?++---++++++--+--+
-+-?++++--++-+++-+--+
-+--++
+-+-++
++-+++-+++++--++++-++
-+++++--++-----+
+----+
-++?-+
--++++
-+---+
--+?-+-++-+---++
+++--+-+++--+--+
+-+?---++-+-+--+
++-+++
-++--+
--+--+
---+++-+--+
--++++
---+-+
+-+--+
+++--+
-++-++
----+-++-++
---+++----+
---+-+
+---+--++++
-----+
---+++
--++++
+-++---++-+
---+-+
-+---+
-+-+-+++-++
--++++
---+-+
++-++++++-+
-+-+++
--++-+
+++--+
---?-+
--+--+
++-++-+-+-+
+-+--+
---+----+++
---+-+
+-+?++
--+--+
+++++-----+
---+-+
--++-+
+-+--+
+++--+
--++-+
--+-++
-+---+
-+-+-+
+-++-++-++-----+
++--++
++---+
+--+-+
+++-+---?-+++++-+++-+
+-++-+
++-+++-+?---+---++?-+
++-+-+-+------++
++++-+
++---+
++-?+-+-+-+
++--++--?-+
--++-+
++----+++++
+-++-+
---+-+
+---+++-+--+-+++
--++-+
++---+
+---++
++++--
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
0.99
-0.99
0.99
-0.99
-0.989
-0.989
-0.989
-0.989
0.988
0.988
-0.988
0.988
-0.987
0.987
-0.986
-0.986
0.986
-0.985
-0.985
-0.985
-0.984
-0.984
-0.983
0.983
-0.983
0.982
-0.982
0.982
-0.981
-0.981
-0.981
-0.981
0.98
0.981
-0.98
-0.98
-0.98
0.979
-0.978
0.978
0.978
-0.978
0.977
0.977
0.977
0.977
-0.976
0.975
-0.975
0.975
0.974
0.974
-0.974
0.973
0.973
0.973
0.973
-0.972
-0.972
-0.971
-0.97
0.97
0.97
-0.97
-0.97
0.97
0.968
0.968
0.968
0.968
0.967
-0.967
0.967
-0.966
-0.966
-0.964
-0.965
0.964
-0.963
0.963
0.962
-0.962
-0.962
-0.962
-0.961
-0.961
0.961
0.96
-0.96
0.96
0.96
0.96
0.959
0.959
0.958
-0.958
-0.958
0.957
0.957
-0.956
0.956
-0.956
0.956
0.956
0.956
-0.956
-0.955
0.955
0.955
0.954
0.954
0.954
-0.954
0.953
-0.953
0.953
-0.953
0.952
0.951
0.95
-0.95
-0.95
0.949
0.949
0.949
-0.948
-0.948
-0.948
0.948
-0.947
-0.946
0.945
0.945
-0.944
0.943
0.943
0.943
-0.943
0.942
-0.942
0.942
0.942
-0.941
-0.941
-0.939
0.939
0.939
-0.938
0.938
0.938
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3.22E-01
3.22E-01
3.22E-01
3.22E-01
3.23E-01
3.23E-01
3.23E-01
3.23E-01
3.23E-01
3.23E-01
3.23E-01
3.23E-01
3.24E-01
3.24E-01
3.24E-01
3.24E-01
3.24E-01
3.25E-01
3.25E-01
3.25E-01
3.25E-01
3.25E-01
3.26E-01
3.26E-01
3.26E-01
3.26E-01
3.26E-01
3.26E-01
3.26E-01
3.26E-01
3.27E-01
3.27E-01
3.27E-01
3.27E-01
3.27E-01
3.27E-01
3.27E-01
3.28E-01
3.28E-01
3.28E-01
3.28E-01
3.28E-01
3.28E-01
3.29E-01
3.29E-01
3.29E-01
3.29E-01
3.30E-01
3.30E-01
3.30E-01
3.30E-01
3.30E-01
3.30E-01
3.30E-01
3.31E-01
3.31E-01
3.31E-01
3.31E-01
3.31E-01
3.31E-01
3.32E-01
3.32E-01
3.32E-01
3.32E-01
3.32E-01
3.32E-01
3.33E-01
3.33E-01
3.33E-01
3.33E-01
3.34E-01
3.34E-01
3.34E-01
3.34E-01
3.34E-01
3.35E-01
3.35E-01
3.35E-01
3.36E-01
3.36E-01
3.36E-01
3.36E-01
3.36E-01
3.36E-01
3.36E-01
3.37E-01
3.37E-01
3.37E-01
3.37E-01
3.37E-01
3.37E-01
3.37E-01
3.37E-01
3.38E-01
3.38E-01
3.38E-01
3.38E-01
3.38E-01
3.39E-01
3.39E-01
3.39E-01
3.39E-01
3.39E-01
3.39E-01
3.39E-01
3.39E-01
3.39E-01
3.39E-01
3.40E-01
3.40E-01
3.40E-01
3.40E-01
3.40E-01
3.41E-01
3.41E-01
3.41E-01
3.41E-01
3.41E-01
3.42E-01
3.42E-01
3.42E-01
3.42E-01
3.43E-01
3.43E-01
3.43E-01
3.43E-01
3.43E-01
3.43E-01
3.43E-01
3.44E-01
3.44E-01
3.45E-01
3.45E-01
3.45E-01
3.46E-01
3.46E-01
3.46E-01
3.46E-01
3.46E-01
3.46E-01
3.46E-01
3.46E-01
3.47E-01
3.47E-01
3.48E-01
3.48E-01
3.48E-01
3.48E-01
3.48E-01
3.48E-01
40067
3206
29816
57519
31082
9955
48115
60827
52288
19642
19928
35234
61764
54638
53603
19090
27224
47732
67180
68143
23986
27894
20150
35986
47390
45837
17779
67607
21137
48568
37500
65827
12926
44551
36190
5116
24019
20971
45660
17122
33625
37378
209
36716
13977
34691
15243
65539
62965
48187
43397
2650
21181
55880
39657
34775
62638
36330
43288
44028
57340
36578
3913
62664
3443
65138
3275
5911
11407
6781
9871
26761
51160
18682
67272
6421
59233
26458
208
38331
28853
29763
33597
1110
26913
48456
60490
16120
44764
1077
24581
40036
2803
52638
67161
43400
14123
441
46957
7249
26337
68505
14712
49153
12424
28559
64561
25687
33
28234
5704
42064
37537
51579
24481
61666
19146
43781
51803
32681
46992
17230
5560
48621
57486
13108
31169
42296
14279
5325
6729
37141
33017
26397
4344
39540
52526
45981
9328
50454
41575
22004
9025
5764
6718
8040
47961
59147
35505
6588
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
9747
54332
126306
6183
84330
9723
57506
25806
2101
55023
9584
2117
153129
5965
29106
29765
4192
11336
55658
10933
51097
255919
25959
55773
256369
64782
7592
51329
63929
7360
11073
10133
84954
6288
84264
84298
9706
2961
64180
84000
30834
3239
6524
221091
285955
8091
133522
79595
134359
112476
57406
539
55027
375035
202299
23548
116535
339855
23650
3831
54187
23476
3241
55666
2123
9726
857
5031
23683
7516
10058
79647
5997
55584
91107
836
64975
25777
6550
8774
4224
2273
8079
84859
93663
26355
64077
57649
27434
11027
55092
6613
5136
64760
10289
5257
171546
7913
197320
4598
10253
8612
54943
4018
10096
7141
81688
11016
10940
4707
5522
3695
51528
286077
55486
5111
84263
26511
29796
113146
57146
64091
83752
22928
79842
3030
4917
23152
93183
154807
6809
143384
51631
4815
283254
84108
23140
5987
9392
4194
253832
92126
64386
10755
100129828
4245
100129828
3749
155061
9701
FAM115A
GDAP1
JSRP1
MRPS12
ZNF414
SEMA3E
MAVS
VAX2
ESRRA
PHIP
RBM39
ETV3
SLC38A9
RECQL
SCG3
TMOD4
MDK
EXOC3
RNF126
MORF4L1
SCCPDH
CNEP1R1
KANK2
TBC1D23
LINC00521
AEN
ZNF41
ARL6IP4
XPNPEP3
UGP2
TOPBP1
OPTN
MPND
SAA1
HAGHL
LLPH
ULK2
GTF2E2
DPEP3
TMPRSS13
ZNRD1
HOXD13
SLC5A2
LRRN4CL
SPDYE1
HMGA2
PPARGC1B
SAP130
POC5
PRRT2
ABHD6
ATP5O
HEATR3
SFT2D2
FIS
TTC33
MRGPRF
KY
TRIM29
KLC1
NANS
BRD4
HPCAL1
NPLOC4
EVI2A
ZNF646
CAV1
P2RY6
PRKD3
XRCC2
ABCB6
AKIRIN1
RGS2
CHRNA9
TRIM47
CASP3
MRPL41
SUN2
SLC9A3
NAPG
MEP1A
FHL1
MLF2
LRCH3
ARHGAP18
FAM162A
LHPP
PHF12
POLM
LILRA2
TMEM51
SUMO2
PDE1A
FAM160B2
EIF1B
PHKB
SPTSSA
DEK
ZNF778
MVK
SPRY2
PPAP2C
DNAJC28
LPA
ACTR3
TNP1
C6orf62
ATF7
POP1
NDUFB1
PPP2R2C
ITGB7
JKAMP
FAM83H
PARL
PCNA
HSDL2
CHIC2
UQCR10
AHNAK2
TMEM159
POPDC2
LONP2
SEPHS2
ZBTB3
HADHA
NTN3
CIC
PIGM
VKORC1L1
STX3
CACUL1
C7orf55-LUC7L2
NINJ2
HARBI1
PCGF6
ZZEF1
TRIM27
TGFBRAP1
MDM4
ZDHHC20
DSEL
MMP25
GIPC1
TAZ
MGAT1
ALG2
KCNC4
ZNF746
PPP6R2
++--++
-++-+++---+
-+-+-+
-+---+
+++--+-+--+
---+++
-+++-+-++---++++++-++
+-+--+-++++-+--+
-+-?+++----+-?-+
-+-?---+-+--++-+-++-+
+++++--+++--+-++
+--+++
+---------+
+++?-++--++-+--+
++--+---+-+
-+-++-+-+++
--+?--++?----++-+++-+
-----+
--++-+
++-+-+
----++
+--+++
---+-+
+++++---+-+
-----+
----++
+--?-+
-++?-+
---+++
+++-++
--+--+
-++-++-++-+---++-++--+--++
---+++
+-++-+
-+-?------+
-+---+
-+++--+---+
+-+++++-----+++-+++-+
-+---+
---+-+
+-++-+
-++-++
++---+
--++--+--++----+
-+--++
+-+---+-+++-----+++-+
-+-+-+
+-+-+--++----+++
++---+
-+--++
+-+--+
++---+
-+-+-+
++--++
--++-+
+++++++--+--++-+
+-+?++---++
-+---+
-++--+
-+--++
++++-+
--+?++-++-+
++-+-+
+-++---++-+
-----+
--+-+-++-++
-+---+
+-++-+
----++
---?++
++++-+
--+--+
+-+--+
--++++
+++++-++-++
+--+-+
----++
-++--+
--++-+
-+-+-+
++--++++--+
+-+-------+
+-++-+
--++++
-+-++++-++++++++--+-+-+--+
--+--+
-+-+-+
-----+
+----+
+-+--+----+
++--++
++++-+
-+---+
-+--++
+++-++
+-+--+
-+--++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
0.938
-0.936
0.936
-0.936
-0.936
-0.933
0.933
0.932
0.932
-0.932
-0.931
0.931
-0.93
0.93
0.929
-0.929
-0.929
0.928
-0.928
-0.928
-0.927
0.925
0.924
-0.924
0.923
-0.923
-0.923
-0.923
0.923
0.922
0.922
-0.922
-0.921
0.921
0.92
-0.92
-0.919
-0.919
0.919
-0.918
0.918
0.918
-0.918
0.917
-0.917
0.917
0.916
-0.916
-0.915
-0.915
0.915
-0.914
0.914
0.913
0.913
-0.913
-0.912
-0.912
-0.912
-0.911
0.911
-0.911
-0.91
-0.91
0.91
0.91
0.909
-0.909
-0.909
0.909
-0.909
-0.909
0.908
0.908
-0.908
-0.908
-0.908
-0.907
0.907
-0.906
0.906
-0.906
0.906
-0.905
0.905
-0.905
-0.904
0.904
0.903
0.903
0.902
-0.902
-0.902
0.901
0.901
-0.9
0.9
-0.899
0.899
0.899
0.899
0.899
0.898
-0.898
0.898
0.897
-0.897
0.897
-0.896
-0.895
0.894
-0.893
0.893
-0.893
-0.892
0.892
-0.891
0.891
0.891
0.891
0.891
0.891
-0.89
-0.889
0.889
-0.889
0.889
0.889
-0.889
-0.888
0.888
0.887
-0.887
0.887
0.886
-0.885
0.885
-0.885
0.884
-0.884
-0.884
-0.883
0.883
0.883
0.883
0.883
0.883
0.883
-0.882
-0.882
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
3.48E-01
3.49E-01
3.49E-01
3.49E-01
3.49E-01
3.51E-01
3.51E-01
3.51E-01
3.51E-01
3.52E-01
3.52E-01
3.52E-01
3.52E-01
3.53E-01
3.53E-01
3.53E-01
3.53E-01
3.53E-01
3.53E-01
3.53E-01
3.54E-01
3.55E-01
3.56E-01
3.56E-01
3.56E-01
3.56E-01
3.56E-01
3.56E-01
3.56E-01
3.56E-01
3.57E-01
3.57E-01
3.57E-01
3.57E-01
3.58E-01
3.58E-01
3.58E-01
3.58E-01
3.58E-01
3.58E-01
3.59E-01
3.59E-01
3.59E-01
3.59E-01
3.59E-01
3.59E-01
3.60E-01
3.60E-01
3.60E-01
3.60E-01
3.60E-01
3.61E-01
3.61E-01
3.61E-01
3.61E-01
3.61E-01
3.62E-01
3.62E-01
3.62E-01
3.62E-01
3.62E-01
3.62E-01
3.63E-01
3.63E-01
3.63E-01
3.63E-01
3.63E-01
3.63E-01
3.63E-01
3.64E-01
3.64E-01
3.64E-01
3.64E-01
3.64E-01
3.64E-01
3.64E-01
3.64E-01
3.64E-01
3.65E-01
3.65E-01
3.65E-01
3.65E-01
3.65E-01
3.65E-01
3.65E-01
3.65E-01
3.66E-01
3.66E-01
3.66E-01
3.67E-01
3.67E-01
3.67E-01
3.67E-01
3.68E-01
3.68E-01
3.68E-01
3.68E-01
3.68E-01
3.69E-01
3.69E-01
3.69E-01
3.69E-01
3.69E-01
3.69E-01
3.69E-01
3.70E-01
3.70E-01
3.70E-01
3.70E-01
3.71E-01
3.71E-01
3.72E-01
3.72E-01
3.72E-01
3.72E-01
3.73E-01
3.73E-01
3.73E-01
3.73E-01
3.73E-01
3.73E-01
3.73E-01
3.74E-01
3.74E-01
3.74E-01
3.74E-01
3.74E-01
3.74E-01
3.74E-01
3.74E-01
3.74E-01
3.75E-01
3.75E-01
3.75E-01
3.76E-01
3.76E-01
3.76E-01
3.76E-01
3.77E-01
3.77E-01
3.77E-01
3.77E-01
3.77E-01
3.77E-01
3.77E-01
3.77E-01
3.77E-01
3.78E-01
3.78E-01
3.78E-01
3824
31358
39701
21704
46912
50243
49698
3358
58068
35567
3172
48666
52450
22456
18340
45541
52551
65090
55930
39930
5861
57591
42217
8697
1225
44930
5209
60850
53863
6362
28798
38250
40249
47045
64820
8628
14894
33738
21715
65851
11169
19771
63410
21288
8784
37797
46028
28711
8819
37672
6567
35544
1145
3618
16367
59457
6050
9524
44309
52235
21486
63929
33666
10368
854
15817
30031
47846
59517
61334
65538
2391
22210
27314
62064
34881
53591
23066
60389
63376
68342
15366
54135
13325
20629
18041
38115
61094
6688
63814
49847
54553
22174
18440
8692
3988
13889
5553
51797
43531
65788
44776
28413
15618
65802
62323
40479
60556
29398
55997
15706
14942
40180
49047
62148
50807
37423
15632
58174
15011
14052
34397
68244
12773
2260
27501
47381
2142
60429
54088
23787
40944
52866
21916
54398
55162
11290
21697
5882
24834
22314
29239
28262
10027
12578
26944
31542
1032
12798
22954
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
155382
349236
79865
55188
23277
23113
5611
92595
8867
80344
11337
25792
49861
79290
92565
51475
55601
3801
2677
283948
3766
135112
10214
80205
518
23558
4843
5710
54867
10691
5925
81856
387496
54511
7317
4758
285962
222546
54872
4065
10957
388951
84224
22845
27249
1293
132660
81889
9039
54910
80267
8189
84073
93380
8534
201254
11315
121260
146
79898
3764
55273
220134
90806
65989
160622
84833
170591
948
9134
10609
10165
90060
79589
150962
10352
84791
6449
3422
10215
284069
463
54776
84333
347168
57804
54738
6573
7718
4988
91283
441272
9738
23334
4097
54937
92999
57228
9878
79149
1838
9516
254887
80067
51375
55222
284254
4892
84948
83483
136051
29911
25864
1062
54716
8997
5372
199974
54819
25827
5694
23135
196394
5046
865
10270
5929
64167
10298
5430
55937
79140
222962
10075
55286
51389
2869
9343
55573
245936
54951
51019
4056
81848
1583
79637
23200
374354
2166
79577
VPS37D
C9orf164
TREML2
RIC8B
CLUH
CUL9
DNAJC3
ZNF764
SYNJ1
DCAF11
GABARAP
CIZ1
CLDN20
OR13A1
FANK1
CABP2
DDX60
KIFC3
GGCX
NHLRC4
KCNJ10
NCOA7
SSX3
CHD9
ATP5G3
WBP2
NOS2
PSMD4
TMEM214
GMEB1
RB1
ZNF611
RASL11A
HMGCLL1
UBA1
NEU1
WEE2-AS1
RFX6
PIGG
LY75
PNRC1
TSPYL6
NBPF3
DOLK
MMADHC
COL6A3
LIN54
FAHD1
UBA3
SEMA4C
EDEM3
SYMPK
MYCBPAP
MMGT1
CHST1
STRA13
PARK7
SLC15A4
ADRA1D
ZNF613
KCNJ8
TMEM100
SKA1
ANGEL2
DLK2
GRASP
USMG5
S100Z
CD36
CCNE2
LEPREL4
SLC25A13
CCDC120
RNF128
PUS10
WARS2
LINC00467
SGTA
IDI1
OLIG2
FAM171A2
ZFHX3
PPP1R12C
PCGF5
OR1J1
POLD4
FEV
SLC19A1
ZNF165
OPRM1
MSANTD3
SPDYE3
CCP110
SZT2
MAFG
SOHLH2
ZBTB47
SMAGP
TOX4
ZSCAN5A
DTNB
LITAF
ZDHHC23
DCAF17
SNX7
LRRC20
DYNAP
NRAP
TIGD5
PLVAP
ZNF786
HOOK2
ABHD14A
CENPE
SLC6A20
KALRN
PMM1
CYP4Z1
ZCCHC10
FBXL2
PSMB6
KDM6B
AMN1
PCSK6
CBFB
AKAP8
RBBP5
ERAP2
PAK4
POLR2A
APOM
CCDC28B
SLC29A4
HUWE1
C4orf19
RWDD1
GRK5
EFTUD2
CDV3
DEFB123
COMMD8
CCDC53
LTC4S
SPRY4
CYP11A1
ARMC7
ATP11B
NHLRC2
FAAH
CDC73
---+-+
-++--+
+-++++-++-++-+++
---+-+
+++?-+
-+-+++-++-++++++++?--+-?++
+---++--+-+
++-----+-++
+-++++
+-++-+
+----+
+++--+
++-+++---+++-?++
++-++--+?-+
+++++-++--+
-+--++
-+---+
-+---+
+-++---++-+---++
+++-++
++---+
-++?-+
---+-++-+++
+----+
-+++-+-+--++++++--++-+-+-+
--++-+----+
+-+----++++-++-+
++---+
++++++----+
+++--+
--+--+
++-+++
---+++
--+--+
+-+--+++--+
--+?++-+-++
-+-+++
---+++----+
-++---+--++++-+-+++++
-+++-+
-+++++-+--+
+-++-+
-+-+++
-++++++++-+
+---+-----+
-+-+-+
+-+-+++-+-+
--+--+--+-+
--++-+
+++?+++-+++
-+-?++
+--+-+
+++--+
--+--+
+-+--+
+-+--++++++-+-+-++--+
+-+?---+--+-+--+
---+-+
+--?----+-+
+----+
+-++-+-+--+
++++-++-+++--+-+
--+--+
+---++
-+-+-+
++-+++++--+
++--++
-+---+
+-+-+-++-++
-+--++
-----+
+-++++++?+-+-+++
-+-+++++----++-+
+---++
+-+-+-----+
--++-+
-++-----+-+
+--?-+
-+-+++
-+++-+
-+---+--+++----+
---+++
++++--+---+
--+--+
+++--+
+-+++--+++++-+-+
+--++++-++-+---+
+-++-+
-++-+--+--+
-++++-
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-0.881
0.881
0.881
-0.881
0.881
-0.88
0.88
0.879
-0.879
0.879
0.879
0.879
-0.879
-0.879
-0.878
0.878
0.878
0.878
-0.877
0.877
0.877
-0.877
0.876
-0.876
0.875
0.875
0.874
0.874
-0.873
-0.873
-0.873
-0.873
0.872
0.872
-0.872
0.872
-0.871
0.871
0.871
-0.871
0.87
0.87
0.869
0.868
-0.868
-0.868
-0.868
0.868
0.867
-0.867
0.867
0.867
0.866
-0.866
0.866
-0.865
-0.864
-0.864
0.863
-0.862
0.862
0.862
-0.862
-0.861
-0.861
-0.861
0.861
0.861
0.861
0.861
-0.86
0.86
0.86
0.86
0.86
-0.859
-0.859
0.859
0.859
0.859
-0.859
0.858
-0.858
-0.858
0.858
0.857
0.857
0.857
-0.857
0.855
-0.855
0.855
-0.855
0.855
0.854
-0.854
0.853
-0.853
-0.852
-0.852
-0.852
0.851
-0.851
-0.85
-0.85
0.849
-0.849
0.849
-0.849
-0.848
0.848
0.847
-0.847
-0.847
0.847
0.847
-0.847
0.846
0.846
0.845
0.844
-0.844
-0.844
0.844
-0.844
-0.842
0.842
-0.842
-0.842
0.84
0.84
-0.84
-0.839
0.839
0.839
-0.839
0.838
-0.838
-0.838
0.837
0.837
0.836
0.836
0.836
0.836
-0.835
0.835
-0.835
0.835
0.833
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3.78E-01
3.78E-01
3.78E-01
3.78E-01
3.79E-01
3.79E-01
3.79E-01
3.79E-01
3.79E-01
3.79E-01
3.79E-01
3.79E-01
3.80E-01
3.80E-01
3.80E-01
3.80E-01
3.80E-01
3.80E-01
3.80E-01
3.81E-01
3.81E-01
3.81E-01
3.81E-01
3.81E-01
3.82E-01
3.82E-01
3.82E-01
3.82E-01
3.83E-01
3.83E-01
3.83E-01
3.83E-01
3.83E-01
3.83E-01
3.83E-01
3.83E-01
3.84E-01
3.84E-01
3.84E-01
3.84E-01
3.84E-01
3.85E-01
3.85E-01
3.85E-01
3.86E-01
3.86E-01
3.86E-01
3.86E-01
3.86E-01
3.86E-01
3.86E-01
3.86E-01
3.86E-01
3.87E-01
3.87E-01
3.87E-01
3.88E-01
3.88E-01
3.88E-01
3.89E-01
3.89E-01
3.89E-01
3.89E-01
3.89E-01
3.89E-01
3.89E-01
3.89E-01
3.89E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.90E-01
3.91E-01
3.91E-01
3.91E-01
3.91E-01
3.91E-01
3.91E-01
3.92E-01
3.92E-01
3.92E-01
3.92E-01
3.93E-01
3.93E-01
3.93E-01
3.93E-01
3.93E-01
3.93E-01
3.94E-01
3.94E-01
3.94E-01
3.94E-01
3.94E-01
3.95E-01
3.95E-01
3.96E-01
3.96E-01
3.96E-01
3.96E-01
3.96E-01
3.96E-01
3.97E-01
3.97E-01
3.97E-01
3.97E-01
3.97E-01
3.97E-01
3.97E-01
3.97E-01
3.97E-01
3.98E-01
3.98E-01
3.99E-01
3.99E-01
3.99E-01
3.99E-01
3.99E-01
4.00E-01
4.00E-01
4.00E-01
4.00E-01
4.01E-01
4.01E-01
4.01E-01
4.01E-01
4.02E-01
4.02E-01
4.02E-01
4.02E-01
4.02E-01
4.02E-01
4.03E-01
4.03E-01
4.03E-01
4.03E-01
4.03E-01
4.03E-01
4.04E-01
4.04E-01
4.04E-01
4.04E-01
4.05E-01
9843
34479
20475
24317
33124
37837
8742
21275
8763
10025
60742
19041
9993
44215
54097
43200
5118
7693
43263
49991
16226
48464
36350
5827
11272
251
27733
48786
12899
17329
64101
32268
7944
35281
39284
49966
61751
21170
16855
3812
61018
51369
625
45435
58581
29589
35408
22268
37479
44836
38581
37694
39215
4069
1425
10198
24933
16312
12532
44786
51223
63760
7169
4770
22606
51629
168
1316
53258
32266
35380
2569
44032
11700
34040
21810
43165
1257
28181
110
44518
14143
62565
52202
2514
38009
16866
11651
46545
32431
10279
36392
43911
57452
35028
50855
50162
16387
2620
7876
9443
56085
64453
66393
39310
10511
39586
62813
65343
11883
49226
22792
26529
27482
39653
45908
12062
33727
37644
54755
2382
23316
57618
20437
28731
5729
65810
31325
64793
1726
20761
56906
383
34297
9715
37871
19138
28010
67061
1778
25367
15970
62214
24170
61665
18162
28504
53700
46340
30849
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
131540
2160
4832
10518
1445
51020
3728
135154
51686
130872
2528
50640
283897
9350
5475
340596
121457
56917
4998
84335
201562
387597
7204
10802
1743
6652
506
8991
10420
10180
51754
84281
1650
254973
22977
54758
100129828
128822
2158
57407
54520
7879
553158
389206
7260
55505
84305
57091
51166
5076
84449
55700
26579
88745
25989
284123
55791
83985
2035
1122
23198
51177
4116
9101
81892
6619
10894
200909
8106
4735
84775
10157
8704
108
120227
9201
123016
22879
1564
25886
64320
57396
3656
79169
152756
143279
284695
51400
246704
79184
51360
91875
27180
2622
79753
54976
4692
284439
203197
25992
84669
5592
9354
64407
1839
26010
80199
4342
85480
51027
22932
10717
4521
2621
23239
79774
140801
4942
145946
390077
9253
63920
54756
90693
56344
9063
2948
58515
6830
1950
387893
9812
8745
84988
375189
81790
5523
283219
54435
27341
100129828
64708
8928
55260
100129828
51160
26993
22920
84203
57051
ZDHHC19
F11
NME3
CIB2
CSK
HDDC2
JUP
C6orf57
OAZ3
AHSA2
FUT6
PNPLA8
C16orf54
CER1
PPEF1
LHFPL1
IKBIP
MEIS3
ORC1
AKT1S1
PTPLB
ILDR2
TRIO
SEC24A
DLST
SORD
ATP5B
SELENBP1
TESK2
RBM6
TMEM8B
C2orf88
DDOST
OR1L4
AKR7A3
KLHDC4
CASC2
CST9
F9
NMRAL1
CCDC93
RAB7A
ARHGAP8
BEND4
TSSC1
NOP10
WIBG
CASS4
AADAT
PAX2
ZNF333
MAP7D1
MYEOV
RRP36
ULK3
FAM27L
LRIF1
SPNS1
EPB41
CHML
PSME4
PLEKHO1
MAGOH
USP8
SLIRP
SNAPC3
LYVE1
HTR3D
PABPN1
SEPT2
ZNF607
AASS
B4GALT2
ADCY2
CYP2R1
DCLK1
TTC8
MON1B
CYP2D7P
POC1A
RNF25
CLK4
IRAK2
C1orf35
FAM218A
HECTD2
ZNF326
PPME1
LINC00315
BRCC3
MBTPS2
TTC5
SIGLEC9
GAS8
SNIP1
C20orf27
NDN
SLC25A42
C9orf91
SNED1
USP32
PRKG1
UBE4A
RGS18
HBEGF
SPATS2L
FUZ
MOS
TSLP
BOLA1
POMZP3
AP4B1
NUDT1
GAS6
PHLPP1
GRTP1
RPL10L
OAT
SPATA8
OR52N2
NUMBL
C5orf54
IL17RD
CCDC126
CABP5
PIAS2
GSTM4
SELK
SUPT6H
EGF
SETD8
KIAA0141
ADAM23
PPP1R16A
PFN4
RNF170
PPP2R3A
KCTD21
HCG4
RRP7A
FRMD6
COPS7B
FOXH1
TMEM143
PLA2G4E
VPS28
AKAP8L
KIFAP3
TXNDC2
NAG18
----++
-++-++
---+++
-++?++
-+---+
---+++
+++-+-+++++
+++--+++--+++--+-++-+-++-+
-+---+
-+++-+
++-+++
-++--+++-++---++
++-+-+-++-+
----++
--++++
+-+--+
+--+++
--+?+---+-+
++-+++-+--+
-+-+-+
--+-+++-++---+-+
-+-+-+
--++--+--++
--+-++-++-+
+-+-+-+-?----+-+
--++-+
-+-+++
----++
----++
++++--+-+-+
--+---+++-+
-+-+++
+-++-+
+----+
-+++++
+--+-+
-+-+-+
++--++
--++-++-+-+
+++++++-++++-++-+-+-+
--++-+-+----++-+--+++--+-+
++---+
----++---+--++++
+--++--+-+-++--+
+--++-+++-+
+----+
-++-++
-++-++
---+++
-----+
--+--+
---?-+
----++
++-+++
-++-----++++--++-+-++
---+++
+-+++---+++-+--+
++---+
-----+
---+++
---+-+
++--+-+++++
+--+++
++++-+--+++-+--+
+-+++++-+++-++-+
+-+-++
-+++-+
-+-?-+
--++---+--+--?-+
-+-++--++-+
---+-+
++---+
++---+
--++--+---+
+++-+++++-+++-++++--+
+-++-+
++-++--++-+
++-+-+
+++++++-+-++++++--+----+++
+---++-+--+
-++--+
+-+--+++-+-+-+-+
++--+--++-+
-++-++
---+++
-+--++
+-+--+
++-++-+-++-+---+
++----+--++
+++-+-
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-0.833
0.833
-0.833
0.833
-0.833
0.832
0.832
0.832
-0.832
-0.831
-0.83
0.83
0.829
0.829
0.829
0.828
-0.828
0.828
-0.827
0.827
0.827
-0.827
0.826
0.826
0.825
-0.825
-0.825
0.825
0.824
0.824
-0.823
0.823
0.822
0.822
-0.822
-0.821
-0.821
0.821
-0.82
-0.82
-0.819
0.818
0.818
0.817
-0.817
0.816
0.815
-0.815
0.814
0.814
0.814
-0.814
0.814
0.813
0.812
0.811
-0.811
0.81
0.809
-0.809
-0.809
0.809
-0.809
-0.808
-0.808
-0.807
0.807
0.806
-0.806
-0.806
0.806
-0.805
-0.805
0.805
-0.805
0.805
-0.805
0.804
0.804
0.804
-0.804
-0.804
-0.804
-0.803
0.803
-0.803
-0.803
-0.803
0.803
-0.802
-0.802
-0.802
0.801
0.8
-0.799
0.8
0.799
-0.799
0.798
0.798
-0.798
-0.798
0.797
0.797
0.797
0.796
0.796
0.796
-0.796
-0.795
-0.795
0.794
0.794
0.794
-0.793
0.793
-0.793
-0.793
-0.792
0.792
0.792
0.792
0.792
0.792
0.792
0.79
0.79
0.79
-0.789
0.789
-0.788
0.788
-0.788
0.787
0.787
-0.786
0.786
0.786
0.786
-0.785
0.785
-0.785
0.785
-0.784
0.784
0.783
-0.783
-0.782
0.782
0.781
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4.05E-01
4.05E-01
4.05E-01
4.05E-01
4.05E-01
4.05E-01
4.06E-01
4.06E-01
4.06E-01
4.06E-01
4.06E-01
4.07E-01
4.07E-01
4.07E-01
4.07E-01
4.07E-01
4.08E-01
4.08E-01
4.08E-01
4.08E-01
4.08E-01
4.08E-01
4.09E-01
4.09E-01
4.09E-01
4.10E-01
4.10E-01
4.10E-01
4.10E-01
4.10E-01
4.10E-01
4.11E-01
4.11E-01
4.11E-01
4.11E-01
4.12E-01
4.12E-01
4.12E-01
4.12E-01
4.12E-01
4.13E-01
4.13E-01
4.14E-01
4.14E-01
4.14E-01
4.15E-01
4.15E-01
4.15E-01
4.15E-01
4.16E-01
4.16E-01
4.16E-01
4.16E-01
4.16E-01
4.17E-01
4.17E-01
4.17E-01
4.18E-01
4.18E-01
4.18E-01
4.18E-01
4.18E-01
4.19E-01
4.19E-01
4.19E-01
4.20E-01
4.20E-01
4.20E-01
4.20E-01
4.20E-01
4.20E-01
4.21E-01
4.21E-01
4.21E-01
4.21E-01
4.21E-01
4.21E-01
4.21E-01
4.21E-01
4.21E-01
4.21E-01
4.22E-01
4.22E-01
4.22E-01
4.22E-01
4.22E-01
4.22E-01
4.22E-01
4.22E-01
4.22E-01
4.23E-01
4.23E-01
4.23E-01
4.24E-01
4.24E-01
4.24E-01
4.24E-01
4.24E-01
4.25E-01
4.25E-01
4.25E-01
4.25E-01
4.25E-01
4.25E-01
4.26E-01
4.26E-01
4.26E-01
4.26E-01
4.26E-01
4.27E-01
4.27E-01
4.27E-01
4.27E-01
4.27E-01
4.28E-01
4.28E-01
4.28E-01
4.28E-01
4.28E-01
4.28E-01
4.28E-01
4.28E-01
4.28E-01
4.29E-01
4.29E-01
4.29E-01
4.29E-01
4.30E-01
4.30E-01
4.30E-01
4.31E-01
4.31E-01
4.31E-01
4.31E-01
4.31E-01
4.32E-01
4.32E-01
4.32E-01
4.32E-01
4.32E-01
4.32E-01
4.32E-01
4.32E-01
4.33E-01
4.33E-01
4.33E-01
4.34E-01
4.34E-01
4.34E-01
4.35E-01
5317
11381
67988
10019
27611
8934
37574
56035
53694
48893
51139
3014
18038
24554
47333
4592
44560
44520
55363
16662
56208
51995
3000
39978
45485
35210
44025
13305
18857
21646
33035
8213
36076
2845
4476
13289
27900
20666
31139
25585
44345
47236
16376
18975
45270
45438
15110
25824
28746
63412
39763
42917
29254
43071
44352
12289
25683
9923
42262
39482
64076
32026
45652
32074
11791
57262
818
21532
25544
67270
61648
7489
18033
20728
45375
9079
60236
16408
43008
67278
13229
13927
45357
9183
56303
54297
22927
24044
17633
45171
45021
65522
29087
42611
16108
12212
55165
34762
55529
51061
11122
44685
10857
4077
21745
3422
40022
21047
19444
23488
622
28300
4939
62458
6777
12447
59521
48826
22843
47261
56453
55650
51901
17171
41466
49922
28455
29825
58145
27323
12164
67551
49401
47032
56661
39133
67857
61915
16705
13819
33788
54859
6541
22946
49485
60712
2071
32747
4150
25221
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
201176
3675
665
390756
79574
6907
90390
10059
9021
56623
7029
22832
8907
23761
6249
196403
125950
26268
27076
57534
8412
2191
347734
389119
23382
55788
5802
55161
6402
4072
53838
10490
6722
92335
5565
93643
55624
4208
63924
64773
327
55101
1441
5646
54815
390442
345275
23600
10116
728695
4350
81789
55841
81788
9141
5169
10617
1260
10274
11082
3014
317761
63875
80010
10089
14
8303
54921
152404
54784
28982
57551
9553
5428
2825
9766
10559
57539
80279
55096
386617
83931
7111
374500
91368
114034
22823
113189
85414
55005
54795
7916
51101
571
144097
7026
79132
85369
55208
4701
144125
3188
3090
9670
124773
404734
11144
348654
5584
11001
79973
22943
4157
57669
51161
29082
2517
9311
64750
4889
55764
22954
79133
79982
11269
6869
154791
1871
55845
10897
6727
10188
1452
29115
58500
7716
55105
5274
160419
318
9170
84296
51156
5175
51629
9630
285220
254863
9993
55038
ARHGAP27
ITGA3
BNIP3L
OR3A4P
EPS8L3
TBL1X
MED30
DNM1L
SOCS3
INPP5E
TFDP2
KIAA1009
AP1M1
PISD
CLIP1
DTX3
RAVER1
FBXO9
LYPD3
MIB1
BCAR3
FAP
SLC35B2
FAM212A
AHCYL2
LMBRD1
PTPRS
TMEM33
SELL
EPCAM
C11orf24
VTI1B
SRF
STRADA
PRKAB2
TJAP1
POMGNT1
MEF2C
CIDEC
PCED1A
APEH
ATP5SL
CSF3R
PRSS3
GATAD2A
OR11H4
HSD17B13
AMACR
FEM1B
SPANXB1
MPG
TIGD6
WWC3
NUAK2
PDCD5
ENPP3
STAMBP
CNGA2
STAG1
ESM1
H2AFX
C14orf39
MRPL17
RMI1
KCNK7
AAMP
SNN
CHTF8
IGSF11
ALKBH4
FLVCR1
TAOK1
MRPL33
POLG
GPR1
KIAA0247
SLC35A1
WDR35
CDK5RAP3
EBLN2
KCTD8
STK40
TMOD1
THSD1P
CDKN2AIPNL
TOE1
MTF2
CHST14
SLC45A3
RMND1
TRPM4
PRRC2A
ZC2HC1A
BACH1
C11orf84
NR2F2
DHX58
STRIP1
DCUN1D2
NDUFA7
OR2AG1
HNRNPH2
HIC1
IPO13
C17orf64
ANKHD1
DMC1
GEN1
PRKCI
SLC27A2
ZNF442
DKK1
MC1R
EPB41L5
C3orf18
CHMP4A
FUCA1
ASIC3
SMURF2
NPY5R
IFT122
TRIM32
NDUFAF5
DNAJB14
DDX19B
TACR1
C7orf55
E2F3
BRK1
YIF1A
SRP14
TNK2
CSNK1A1
SAP30BP
ZNF250
VEZF1
GPATCH2
SERPINI1
C12orf50
NUDT2
LPAR2
GINS4
SERPINA10
PECAM1
SLC25A39
GNA14
EPHA6
TMEM256
DGCR2
CDCA4
-++--+
---?-+
+-+?+-----+
-----+
-----+
+-+++-++?++-+--+--+-+
+++++--++--+---+
-++---+++-+---++
-+---+
++-++-+-+++
+-++-+-+--+
++-++-+---+
++--++
---+-+
+-+--++-+++
+-+--+
---+-+
+++++++-+-+
+++++---?++
+++--+
+----+
----++
-+-+-+
-+++--+-+-+
-++---+++-+
-+-+-+
+-+--+++-++
++---+
-+-+++
+-+?-+
----++-+--+++-++--+++--+++
+++-+--+-++
---+-+
+-+----++++
-+++++
+-+--+--++-++--+
--+?+-+--++-+++++---+
---+-+
+-+?--+-+++
--++++
-----+
+++--++-++--+?++
++-+-+
+++?-+
+-+--+
+-++++
++----+-+++
++++--+++-+
++++-+
++-++--++-+
+++--+
++++--+++--+--++
+-+----++-+
-+++-+
++--++
+-++++-++++----+
++---+
++++-+
+----+
+---+-+-+-+
+++--+
+-++-+++++---+-+
+--+++
+--+-+
+++---+-+-+-+--++++--++--+
++-+++
++-+++
-----+
+---++
---+-+
--++---++++
---++---+-+
+--+-+
+---+--++---++++++++-++-++++--+
+-+?-+
+--+++
---+-+
-+-+++
-----+
+-+-+-++--+
--++-+
----++
---++++--++
-++-++
-+-+++
+++--+
+-+--+
----++
+-+--+
++-+++++-++--+++
---+++++--+
+---++
7257
6376
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
0.78
-0.78
-0.78
0.78
-0.78
-0.78
0.779
-0.778
-0.778
-0.778
0.778
-0.778
0.776
-0.776
-0.774
0.774
-0.774
0.773
0.773
-0.772
0.772
0.771
0.771
0.77
-0.77
-0.77
0.77
0.769
-0.769
0.769
0.769
0.769
0.768
0.767
0.767
-0.767
-0.765
0.765
-0.765
-0.765
0.765
0.764
0.764
0.763
-0.763
0.764
0.763
-0.762
-0.762
0.762
0.761
0.761
0.76
-0.759
-0.759
-0.758
0.758
0.758
-0.758
0.757
-0.757
0.756
-0.756
0.755
0.753
-0.753
-0.753
0.753
0.752
0.752
0.751
-0.751
-0.751
0.75
0.75
0.75
0.75
-0.75
0.749
0.749
0.748
0.748
0.748
-0.748
0.748
0.747
-0.747
0.747
0.746
-0.746
0.745
0.745
0.745
-0.743
-0.743
0.743
0.743
0.743
-0.742
-0.741
0.741
-0.741
0.741
-0.74
0.74
-0.739
-0.739
-0.738
-0.738
0.737
0.737
0.737
0.737
-0.737
0.736
0.736
-0.735
0.735
-0.735
0.734
-0.734
-0.734
-0.734
-0.733
0.733
-0.732
-0.731
-0.731
0.731
-0.731
0.73
-0.73
-0.729
-0.729
0.729
-0.728
-0.727
0.727
0.726
0.725
-0.725
-0.725
0.725
0.725
0.725
0.725
0.725
-0.724
0.724
0.724
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4.35E-01
4.35E-01
4.35E-01
4.35E-01
4.35E-01
4.36E-01
4.36E-01
4.36E-01
4.37E-01
4.37E-01
4.37E-01
4.37E-01
4.38E-01
4.38E-01
4.39E-01
4.39E-01
4.39E-01
4.39E-01
4.40E-01
4.40E-01
4.40E-01
4.41E-01
4.41E-01
4.41E-01
4.41E-01
4.41E-01
4.42E-01
4.42E-01
4.42E-01
4.42E-01
4.42E-01
4.42E-01
4.42E-01
4.43E-01
4.43E-01
4.43E-01
4.44E-01
4.44E-01
4.44E-01
4.44E-01
4.45E-01
4.45E-01
4.45E-01
4.45E-01
4.45E-01
4.45E-01
4.45E-01
4.46E-01
4.46E-01
4.46E-01
4.47E-01
4.47E-01
4.47E-01
4.48E-01
4.48E-01
4.48E-01
4.48E-01
4.49E-01
4.49E-01
4.49E-01
4.49E-01
4.50E-01
4.50E-01
4.50E-01
4.51E-01
4.51E-01
4.52E-01
4.52E-01
4.52E-01
4.52E-01
4.53E-01
4.53E-01
4.53E-01
4.53E-01
4.53E-01
4.53E-01
4.53E-01
4.54E-01
4.54E-01
4.54E-01
4.54E-01
4.54E-01
4.54E-01
4.55E-01
4.55E-01
4.55E-01
4.55E-01
4.55E-01
4.55E-01
4.56E-01
4.56E-01
4.56E-01
4.57E-01
4.57E-01
4.57E-01
4.58E-01
4.58E-01
4.58E-01
4.58E-01
4.59E-01
4.59E-01
4.59E-01
4.59E-01
4.59E-01
4.60E-01
4.60E-01
4.60E-01
4.60E-01
4.61E-01
4.61E-01
4.61E-01
4.61E-01
4.61E-01
4.61E-01
4.62E-01
4.62E-01
4.62E-01
4.63E-01
4.63E-01
4.63E-01
4.63E-01
4.63E-01
4.63E-01
4.63E-01
4.64E-01
4.64E-01
4.65E-01
4.65E-01
4.65E-01
4.65E-01
4.65E-01
4.65E-01
4.66E-01
4.66E-01
4.66E-01
4.67E-01
4.67E-01
4.67E-01
4.68E-01
4.68E-01
4.68E-01
4.68E-01
4.69E-01
4.69E-01
4.69E-01
4.69E-01
4.69E-01
4.69E-01
4.69E-01
4.69E-01
54674
62018
12394
2077
13018
58061
36582
18562
52380
36167
17955
1102
25032
42053
28994
60480
9265
6415
39639
51925
15031
12655
38660
36737
8480
48858
6046
492
27133
38220
49236
33610
52843
13288
38674
66814
30473
1564
33159
26043
19556
27604
44447
36881
13145
36545
49410
6167
29403
30602
19234
20296
2800
29878
35918
47566
25052
40415
52486
63573
58252
9390
20499
36191
23777
66255
67921
67219
10892
50749
38017
18524
40738
7611
49715
18216
45382
20509
30223
60144
63626
53873
28967
36697
38652
13451
6323
6766
21871
45307
7156
34942
10349
31317
53713
42121
54819
25758
33101
61852
67087
16183
36625
40466
28818
30414
9312
9827
43939
52975
60439
6497
33585
4154
42742
38986
59336
62310
43685
33260
32600
43207
52418
24675
41212
47319
41894
63467
68263
61112
36708
52647
32710
4782
11517
14693
10677
41297
24617
22054
2057
46420
50323
62475
32883
29930
51949
12640
48962
54693
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
56262
25796
57226
3185
158787
9125
360200
85458
140766
440423
8724
56261
6429
2914
79144
2940
55212
6671
2676
9400
1497
2624
79626
29774
81469
27254
140456
152815
1142
283767
23417
6944
285521
8683
29063
55066
79641
30849
7083
148
157657
909
2952
944
9489
6778
7741
7804
4209
8651
4734
140686
4286
283455
4248
168451
4152
30845
54866
83547
64928
10786
10430
26157
91647
84661
27067
57470
115548
84996
23788
10114
2052
124404
3356
54769
54982
9022
2077
55049
84280
55018
760
10599
91300
146540
7110
83886
9785
5817
8647
27000
54510
4696
7186
6009
116138
55697
9665
51264
9556
5586
339559
1869
5533
85007
60677
55630
60559
8853
10960
166815
51186
26608
643866
3028
84889
143879
5157
8794
84167
55823
51665
80179
8566
7844
245711
2155
9412
55655
83844
5314
390078
83723
23503
55027
84261
904
29990
124245
92960
55108
85377
9869
197258
256643
146434
55007
127396
202052
LRRC8A
PGLS
LYRM2
HNRNPF
RIBC1
RQCD1
TMPRSS9
DIXDC1
ADAMTS14
SUZ12P
SNX3
GPCPD1
SRSF4
GRM4
PPDPF
GSTA3
BBS7
SP4
GFRA3
RECQL5
CTNS
GATA2
TNFAIP8L2
POM121L9P
OR2G3
CSDC2
ASB11
THAP6
CHRNB3
GOLGA6L1
MLYCD
VPS72
COX18
SRSF9
ZCCHC4
PDPR
ROGDI
PIK3R4
TK1
ADRA1A
C8orf37
CD1A
GSTT1
TNFSF8
PGS1
STAT6
ZSCAN26
LRP8
MEF2D
SOCS1
NEDD4
WFDC3
MITF
KSR2
MGAT3
THAP5
MBD1
EHD3
PPP1R14D
RILP
MRPL14
SLC17A3
TMEM147
GIMAP2
ATPAF2
DPY30
STAU2
LRRC47
FCHO2
C21orf119
MTCH2
HIPK3
EPHX1
SEPT12
HTR2A
DIRAS2
CLN6
CLIC3
ERF
C19orf60
BTBD10
LINC00483
CA2
SLCO1B1
R3HDM4
ZNF785
TMF1
PRSS27
DHX38
PVR
ABCB11
DNAJC2
PCDH18
NDUFA3
TRAF2
RHEB
KLHDC3
VAC14
KIAA0430
MRPL27
C14orf2
PKN2
ZFP69
E2F1
PPP3CC
PHYKPL
CELF6
SLC39A4
SPCS3
ASAP2
LMAN2
TIGD2
WBP5
TBL2
CBLN3
HSD17B10
SLC7A3
KBTBD3
PDGFRL
TNFRSF10C
C19orf44
VPS11
ASB1
MYO19
PDXK
RNF103
SPDYA
F7
MED21
NLRP2
USP26
PKHD1
OR52E6
FAM57B
ZFYVE26
HEATR3
FBXW9
CCNT1
PILRB
ZC3H18
PEX11G
BSDC1
MICALL1
SETDB1
FUK
CXorf23
ZNF597
FAM118A
ZNF684
DNAJC18
-+--++
-+++-+
---+++
+-+--+
-+-+-+
---++-+-++-+-+++
-+-+++
++++++-++++-+-------+
--+-++
++-+++
+----+
+--+-+-++-+
-+-----+?-+
-+---+
+-+---+++-+
+-++++
-++++---?++
-+++++---+-++++++++---++-+
-----+
+++++--++-+
+-+++++---+
+++++-+++-+
---+++
-+++++
+++----+-++--+-+
--++-+
+-+-++
+-+--+
++---+-+--+
-+--++
-+++++
+-+-+-++-----?-+
----++
+---++
++-+-++---+
+-++++-+-++
++++--+-+++
++-++---+-+
--+++-----+
--+?++
+-+-------+
+-+--+-+--+
-++--+
+-+----++++-++-+
+-++-+
-+--++
--+--+
-+-+++
--+--+---++
+-+?--+--++--+++--+++
++-++-++?-+
++++-++-+++
---?-+
--++-+
++--+-+--+---+++
-+-+-+
-+-?-+
+-+--+
---+-+
---+-+
++--+-+-?-+
-+-+++
-+++-++--++
++---+
++--++
+--+-+
+--+++
--+--+
--++-+-+++-+-+++
----++
-+-++---+-+
+---++
-+-+-+
--+-++
--+++---?++
+++++-+-+-+
-+-+-+
-+---+
-+-+-+
-----+
+-+--+++--+-++++-++--++--+
+-+--+-------++++---+
---+++
--++-+
+-+--+
-+-++-+-+++
+++--+
++---+
++---+
-+-+-+
++---+
+--+-+
+-+-+-+-+-+
++--+--+--+
++-+--
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-0.724
-0.721
0.721
-0.721
0.721
-0.721
-0.72
0.72
0.72
0.72
0.719
-0.719
-0.718
0.718
0.717
-0.717
-0.717
-0.717
-0.715
-0.715
-0.715
-0.714
-0.714
0.713
0.713
-0.713
0.712
-0.711
0.711
-0.711
-0.71
-0.71
-0.71
-0.71
-0.71
0.709
0.709
-0.708
0.708
0.708
0.707
-0.707
-0.707
0.706
0.706
0.706
-0.706
0.706
0.705
0.705
-0.705
-0.705
0.704
-0.704
0.704
-0.704
-0.703
0.703
0.703
0.703
-0.702
0.702
-0.701
0.701
-0.701
0.701
-0.701
-0.7
-0.7
0.699
0.698
0.698
-0.698
0.698
-0.698
0.697
-0.697
0.696
-0.696
0.696
0.696
-0.695
-0.695
0.694
0.694
0.694
0.693
0.693
-0.693
0.693
0.692
-0.692
0.691
-0.691
-0.691
0.691
-0.691
-0.691
0.69
0.69
0.69
0.69
0.689
0.689
0.689
0.689
0.688
-0.688
-0.688
-0.688
0.687
-0.687
-0.686
-0.686
-0.685
0.685
0.685
-0.684
-0.684
0.684
-0.683
0.683
0.683
0.683
0.683
-0.682
0.682
0.682
-0.682
-0.682
0.682
-0.681
-0.68
0.679
0.68
0.679
0.679
-0.679
0.679
0.678
0.678
0.676
0.676
0.676
-0.676
-0.675
-0.675
0.675
-0.675
-0.675
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
4.69E-01
4.71E-01
4.71E-01
4.71E-01
4.71E-01
4.71E-01
4.72E-01
4.72E-01
4.72E-01
4.72E-01
4.72E-01
4.72E-01
4.73E-01
4.73E-01
4.73E-01
4.73E-01
4.74E-01
4.74E-01
4.75E-01
4.75E-01
4.75E-01
4.75E-01
4.75E-01
4.76E-01
4.76E-01
4.76E-01
4.77E-01
4.77E-01
4.77E-01
4.77E-01
4.77E-01
4.78E-01
4.78E-01
4.78E-01
4.78E-01
4.78E-01
4.79E-01
4.79E-01
4.79E-01
4.79E-01
4.80E-01
4.80E-01
4.80E-01
4.80E-01
4.80E-01
4.80E-01
4.80E-01
4.80E-01
4.81E-01
4.81E-01
4.81E-01
4.81E-01
4.81E-01
4.81E-01
4.82E-01
4.82E-01
4.82E-01
4.82E-01
4.82E-01
4.82E-01
4.82E-01
4.83E-01
4.83E-01
4.83E-01
4.83E-01
4.84E-01
4.84E-01
4.84E-01
4.84E-01
4.85E-01
4.85E-01
4.85E-01
4.85E-01
4.85E-01
4.86E-01
4.86E-01
4.86E-01
4.86E-01
4.87E-01
4.87E-01
4.87E-01
4.87E-01
4.87E-01
4.88E-01
4.88E-01
4.88E-01
4.88E-01
4.88E-01
4.88E-01
4.88E-01
4.89E-01
4.89E-01
4.89E-01
4.89E-01
4.89E-01
4.89E-01
4.89E-01
4.90E-01
4.90E-01
4.90E-01
4.90E-01
4.90E-01
4.91E-01
4.91E-01
4.91E-01
4.91E-01
4.91E-01
4.91E-01
4.91E-01
4.92E-01
4.92E-01
4.92E-01
4.92E-01
4.93E-01
4.94E-01
4.94E-01
4.94E-01
4.94E-01
4.94E-01
4.94E-01
4.94E-01
4.94E-01
4.95E-01
4.95E-01
4.95E-01
4.95E-01
4.95E-01
4.95E-01
4.95E-01
4.95E-01
4.95E-01
4.96E-01
4.97E-01
4.97E-01
4.97E-01
4.97E-01
4.97E-01
4.97E-01
4.97E-01
4.98E-01
4.98E-01
4.99E-01
4.99E-01
4.99E-01
4.99E-01
5.00E-01
5.00E-01
5.00E-01
5.00E-01
5.00E-01
7271
59926
13756
67971
67643
52779
53740
61910
13959
30688
32948
66756
7767
42586
45472
20391
24027
16754
30065
27435
42261
55203
55542
15554
24541
40793
13572
4175
59074
51865
60626
68533
26571
33780
37933
55172
2259
11076
34950
50154
17638
29332
40575
64545
48660
47051
41998
55615
54650
53298
18972
40013
44829
68105
58789
62574
30655
22665
62955
20356
54767
5222
11106
67234
49767
26920
31409
11616
44667
27782
9404
41791
8202
11136
29360
30247
11013
45095
62328
44304
47211
26370
44474
57755
68148
17085
7119
43696
3558
21590
45982
14103
15847
12340
35432
29836
31404
4046
36095
47300
3311
2222
20982
5815
52650
36435
28892
3086
55583
19972
64750
13326
31461
19125
27505
5182
4246
18227
39648
27517
8994
16307
18529
47294
8458
12492
30317
5888
55234
27093
36080
54605
39343
50949
33891
24710
40606
57168
12951
62560
13247
41635
47780
59756
20379
65650
24935
32032
12417
43853
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
10642
309
5414
152831
6001
9902
27005
55916
89796
10681
51250
4656
155060
5310
3269
811
64393
9230
9403
10614
26523
81631
56965
51300
54623
114822
4301
50814
152992
3664
83401
8996
9776
285696
166012
6710
126208
26580
54930
286256
56257
7477
79575
24145
84688
80774
26470
4150
1548
3017
27163
1043
56984
151011
144423
3821
49860
401665
140807
7156
100129828
79446
7917
284
8943
283431
54988
10650
6699
10552
84681
29103
969
26007
55616
388818
147650
54072
51542
54928
84717
9441
9651
8394
842
81555
340385
56654
55011
92304
79831
79153
8802
57568
51616
56605
9942
2978
91966
10857
113000
55300
51647
5932
401253
2222
117178
84262
8773
1182
3565
23440
8650
83538
79571
126526
115939
388289
65975
6655
1392
78992
84680
7634
4193
165082
56946
3574
80150
23584
84440
59343
7205
90333
6005
172
6422
213
80059
51295
256329
56203
80758
5596
7415
1031
147699
54998
10261
3680
IGF2BP1
ANXA6
SEPT4
KLB
RGS10
MRC2
USP21
NXT2
NAV1
GNB5
C6orf203
MYOG
LOC155060
PKD1
HRH1
CALR
ZMAT3
RAB11B
RP4-604K5.1
HEXIM1
AGO1
MAP1LC3B
PARP6
TIMMDC1
PAF1
RHPN1
MLLT4
NSDHL
TRMT44
IRF6
ELOVL3
NOL3
ATG13
AC091878.1
CHST13
SPTB
ZNF787
BSCL2
HAUS4
LCN12
MEPCE
WNT7B
ABHD8
PANX1
C9orf24
LIMD2
SEZ6L2
MAZ
CYP2A6
HIST1H2BD
NAAA
CD52
PSMG2
SEPT10
GLT1D1
KLRC1
CRNN
OR51T1
KRT72
TOP3A
MACROD2
WDR25
BAG6
ANGPT1
AP3D1
GAS2L3
ACSM5
SLMO1
SPRR1B
ARPC1A
HINT2
DNAJC15
CD69
DAK
ASAP3
KRTAP26-1
LINC00085
LINC00158
VPS54
IMPAD1
HDGFRP2
MED26
PLCH2
PIP5K1A
CASP9
YIPF5
ZNF517
NPDC1
PIH1D1
SCGB3A1
KDM8
GDPD3
SUCLG1
SIPA1L2
TAF9B
ERO1LB
XYLB
GUCA1A
CXorf40A
PGRMC1
RPUSD1
PI4K2B
FAM96B
RBBP8
LINC00336
FDFT1
SSX2IP
PSMG3
SNAP23
CLCN3
IL4
OTP
NUMB
TTC25
GCC1
C19orf47
TSR3
C16orf47
STK33
SOS2
CRH
YIPF2
ACCS
ZNF80
MDM2
GPR113
C11orf30
IL7
ASRGL1
VSIG2
RAB11FIP4
SENP2
TRIP6
ZNF468
RHAG
AFG3L1P
SFRP1
ALB
LRRTM4
ECSIT
C11orf35
LMOD3
PRR7
MAPK4
VCP
CDKN2C
PPM1N
AURKAIP1
IGSF6
ITGA9
++++-++---+
--++-+
-++++---+++-----+---+
+-++++-+-++
++-++-+++---+++++--++
-+---+
-+--+-+---+
-+-+++
++-++--++-+
-+-++-+-+-+
+-+-++---++----+
++---+
+----+
++--+---+-+
---+-+
+--+-+
+-+--+
+-++++
++-+-+
--+--+
--+-++
++-++-+-++-+-+++
--+?-+
+--+++
-+---+
-++++--++-+-+---+-?-+
-+---+
-----+
-++++++-++--+--+
-+-+-+
-+-+++
--++-+
+--+++
+----+
--+--+
+----+
+++-++-+++-+++-+
+++--+
-----+
++-+++++++---+-+
+++++-++-++
-+-++-+++++-+--+
-+-+++
+-+-++
--+++++++-+
+---++
-+-+++
+----+
+++-++-+--+
+++--+
-+--++
-+---+
+----+
--++--++--+
+-+--+
-+-+-+
-+---+
-+--++
+---++
+----+
+--?-+
--++-+
+-+--+-++++
--+-+-++--+
-+-?++
-+-+-+
+++++-+-+-+---+++--++
+-+++--+--+
+-++-+
+-+++-+--++
+-+--+--+++-+----+--+
+-+--+
+--+++-+--+
++++-+
--+--+
-+-+++
++-+-+-++-++---+
+--+-++++-+---++
+--+++
-++--+
++-+--+--++
+-+--+
+---++-+--+
+-+-++++--+
+--+-+
++-+++--+++
+---++
--+-++
++---++-++--+?-+++--+
-+--++
--++++
-+---+
--++++
++-++--++--+++-++---+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
0.675
-0.673
-0.672
0.672
-0.672
-0.672
-0.671
0.671
0.671
0.671
-0.67
0.67
-0.669
-0.669
-0.669
0.668
0.667
0.667
-0.666
-0.666
0.666
-0.666
-0.665
-0.664
-0.664
0.664
-0.663
-0.663
-0.663
0.663
0.663
0.662
0.662
0.662
0.662
0.662
0.661
0.661
-0.661
0.661
-0.661
0.66
-0.658
-0.658
-0.658
-0.657
-0.657
0.657
0.657
-0.656
0.656
0.656
-0.656
0.656
-0.655
-0.655
-0.654
0.654
0.654
0.654
0.654
-0.653
0.653
0.653
-0.653
-0.651
0.649
0.649
0.649
0.648
0.647
0.647
-0.647
0.647
0.647
0.646
-0.646
-0.646
-0.645
0.645
0.645
-0.645
-0.644
-0.644
0.644
-0.644
-0.643
-0.643
0.642
-0.642
-0.641
-0.641
0.641
-0.641
0.64
-0.64
-0.64
0.639
0.639
0.638
-0.638
-0.637
0.637
0.636
0.636
0.636
-0.636
-0.636
0.635
-0.635
0.634
-0.634
0.633
-0.633
0.633
0.633
-0.633
0.631
-0.631
0.63
0.63
-0.629
0.629
-0.629
0.628
0.627
-0.627
0.626
0.626
-0.626
0.625
0.625
0.624
-0.624
0.623
0.623
-0.623
0.623
-0.622
-0.622
-0.622
0.622
-0.621
0.621
0.621
0.621
0.62
-0.619
0.619
0.619
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
5.00E-01
5.01E-01
5.01E-01
5.02E-01
5.02E-01
5.02E-01
5.02E-01
5.02E-01
5.02E-01
5.02E-01
5.03E-01
5.03E-01
5.03E-01
5.04E-01
5.04E-01
5.04E-01
5.05E-01
5.05E-01
5.05E-01
5.05E-01
5.06E-01
5.06E-01
5.06E-01
5.07E-01
5.07E-01
5.07E-01
5.07E-01
5.07E-01
5.07E-01
5.08E-01
5.08E-01
5.08E-01
5.08E-01
5.08E-01
5.08E-01
5.08E-01
5.08E-01
5.09E-01
5.09E-01
5.09E-01
5.09E-01
5.09E-01
5.10E-01
5.11E-01
5.11E-01
5.11E-01
5.11E-01
5.11E-01
5.11E-01
5.12E-01
5.12E-01
5.12E-01
5.12E-01
5.12E-01
5.12E-01
5.13E-01
5.13E-01
5.13E-01
5.13E-01
5.13E-01
5.13E-01
5.14E-01
5.14E-01
5.14E-01
5.14E-01
5.15E-01
5.16E-01
5.16E-01
5.17E-01
5.17E-01
5.17E-01
5.17E-01
5.18E-01
5.18E-01
5.18E-01
5.18E-01
5.18E-01
5.19E-01
5.19E-01
5.19E-01
5.19E-01
5.19E-01
5.19E-01
5.19E-01
5.20E-01
5.20E-01
5.20E-01
5.20E-01
5.21E-01
5.21E-01
5.21E-01
5.22E-01
5.22E-01
5.22E-01
5.22E-01
5.22E-01
5.22E-01
5.23E-01
5.23E-01
5.23E-01
5.24E-01
5.24E-01
5.24E-01
5.25E-01
5.25E-01
5.25E-01
5.25E-01
5.25E-01
5.25E-01
5.25E-01
5.26E-01
5.26E-01
5.26E-01
5.27E-01
5.27E-01
5.27E-01
5.27E-01
5.28E-01
5.28E-01
5.29E-01
5.29E-01
5.30E-01
5.30E-01
5.30E-01
5.30E-01
5.30E-01
5.31E-01
5.31E-01
5.31E-01
5.31E-01
5.32E-01
5.32E-01
5.32E-01
5.33E-01
5.33E-01
5.33E-01
5.34E-01
5.34E-01
5.34E-01
5.34E-01
5.34E-01
5.34E-01
5.34E-01
5.34E-01
5.35E-01
5.35E-01
5.35E-01
5.36E-01
5.36E-01
5.36E-01
17801
35481
10400
57646
28706
6012
13761
7398
16290
32595
46342
48609
67428
63750
13324
13195
10829
4002
9254
2782
5789
13739
35291
24549
65042
36105
51885
45222
60791
64746
23052
64160
5061
28174
3944
4086
23469
20769
38214
10434
36535
47733
17766
49206
3012
29897
48689
54413
13249
64667
21026
51769
21189
47947
32039
41155
38943
10273
58715
64549
7010
53211
68492
5842
66030
12970
11908
41593
47539
38210
38452
50133
67389
60696
53565
66650
48501
48765
65989
9420
8700
45212
64097
66138
34553
13957
50359
12486
23694
30270
52797
57307
20580
9281
18790
60882
65750
6841
62992
18439
49581
10101
12963
26991
7388
28739
22491
44992
12257
57185
8377
7678
57819
7353
17430
43959
13481
48777
53608
7918
8448
9129
47071
35789
15181
9995
33636
16455
16656
60432
6342
61541
10879
18348
35716
21937
23839
62023
21291
55893
13658
52524
63462
19531
1751
27759
45889
55064
52199
23969
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
84099
5610
9027
79609
55254
9830
1415
79763
57099
25
284186
9424
29945
53340
3816
8835
90268
9416
54785
7052
24148
9587
7409
51263
7351
130507
9783
50865
54969
92579
7001
2135
11160
60675
337880
2184
89797
23438
7707
63931
1649
9353
6839
145553
9867
5824
27342
9688
401152
57132
81858
3050
26740
7284
200728
80054
272
2665
100129828
2134
59353
8559
116372
5042
3445
5333
9328
79006
64850
26499
9356
2764
127795
9819
339457
1902
58531
9827
400073
51384
114897
56
1951
220441
6390
26269
8843
161835
158160
9486
22948
6844
79165
56953
50939
51592
116541
27328
8443
29098
4213
79607
64073
3607
51082
81037
27109
7053
55352
100129828
9917
8603
10385
10927
9317
8310
51646
400120
116115
10257
170954
25934
51098
91978
25879
9851
100129828
9570
54832
25839
7576
54108
5096
285489
2637
818
23355
1419
3202
26164
3604
283174
54927
63897
128439
55748
113419
57409
54942
84532
ID2B
EIF2AK2
NAT8
METTL21D
TMEM39A
TRIM14
CRYBB2
ISOC2
AVEN
ABL1
TMEM105
KCNK6
ANAPC4
SPA17
KLK1
SOCS2
FAM105B
DDX23
C17orf59
TGM2
PRPF6
MAD2L1BP
VAV1
MRPL30
UCP2
UBR3
RIMS3
HEBP1
C4orf27
G6PC3
PRDX2
EXTL2
ERLIN2
PROK2
KRTAP11-1
FAH
NAV2
HARS2
ZNF148
MRPS14
DDIT3
SLIT2
SUV39H1
MDP1
PJA2
PEX19
RABGEF1
NUP93
C4orf3
CHMP1B
SHARPIN
HBZ
OR1J2
TUFM
TMEM17
CEBPA-AS1
AMPD3
GDI2
MAGT1
EXTL1
TMEM35
PRPF18
LYPD1
PABPC3
IFNA8
PLCD1
GTF3C5
METRN
ETNPPL
PLEK2
SLC22A6
GMFB
C1orf87
TSC22D2
C1orf222
LPAR1
PRM3
RGP1
C12orf76
WNT16
C1QTNF1
ACRV1
CELSR3
RNF152
SDHB
FBXO8
HCAR3
FSIP1
HSD17B7P2
CHST10
CCT5
VAMP2
LENG1
NT5M
IMPG2
TRIM33
MRPL54
PCDH11X
GNPAT
RANGRF
MEIS3P1
FAM118B
C19orf33
FOXK2
POLR1D
CLPTM1L
ATP5S
TGM3
COPRS
NANOGP1
FAM20B
FAM193A
BTN2A2
SPIN1
PTER
ACOX3
YPEL5
SERTM1
ZNF526
ABCC4
PPP1R18
NIPSNAP3A
IFT52
TPGS1
DCAF13
KIAA0753
GALNT9
GOSR2
VPS13C
COG4
ZNF28
CHRAC1
PCCB
DOK7
GBX2
CAMK2G
VPS8
CRYGB
HOXA5
MTG2
TNFRSF9
MIR4697
CHCHD3
HEATR6
SNHG11
CNDP2
TEX261
MIF4GD
FAM206A
ACSS1
--+--+
++++-++++++-+----+--+
++-?++--+-+
--++-+
--++-+
-----+
++---+
---+-+
+---++
+-+++++---+
+--++--++-+
++---+
++--++
++-?+--++-++-?++
-++--+
++++--+-+++
+++-+-----+
+++----++----+++
++--++--+---++++
+-+----+-++
++++-+
+--+++----+
-+--+---+-+
+-+--+
--+--+
++-+++
--++-+
+-+--+
+--+-+
+++-----+-+
--+++--+--+
++-+++++++-+--++
-+-+-+
+++--+-+--+
+----+
--+--+
+--++--+-++
+------++--++++--+?-+
--++-++---+
-+-+-+
+-++-+
+----+
++-++-++-++
--++++
++--++-+--+
-++-++
+--+-+
---+++
+-+--+
+-+-----+-+
-+-+++
+---++
+--?-+
++-+-+
--++-+
+-++-+-+-++-++-+
+-++-++--++
+--+-+
-++--+
-++--+
++---+
-+++++-+-++
---+++
---+++-++-+
--++---++-+-+-++
+++++-++--+
++-++-+--++
+-+++++++-+
--++-+
-+--++
++---+
+----+
+-+--+
-+-++++-+-+
---+-+
+-+++-++++-+---+
+-+-+++---+
+-+?--+++++-++++++--+
+-+--+
-+-+++
-+-+++
+--++++---+
--+++-+++----+++
-+-+-+
+-++-+
+-+--+
-+++---+--+
-+++-+
-+-+-+
+-+-++
++-++--+--+
+--+-+
++--++
-+-+-+
-+-+-+
++-?-+
--+++-+---+
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
0.618
0.618
0.618
-0.618
0.617
0.617
0.616
-0.615
0.615
-0.615
0.615
-0.615
0.613
-0.613
0.613
0.612
0.612
-0.612
0.612
-0.612
-0.611
0.611
-0.611
0.611
0.61
-0.61
-0.609
0.609
-0.609
0.609
0.609
-0.609
0.608
0.608
0.607
0.607
-0.607
-0.607
-0.606
-0.606
0.606
0.605
0.605
-0.605
-0.604
0.604
-0.604
-0.603
-0.603
0.602
0.602
-0.602
0.6
-0.6
-0.6
0.6
-0.6
-0.599
0.599
0.599
-0.599
-0.598
0.598
-0.597
-0.597
0.597
-0.597
0.597
0.595
0.595
0.595
0.595
0.594
0.594
0.594
-0.593
0.592
-0.592
-0.592
-0.592
0.591
0.59
0.59
0.59
0.59
0.589
-0.589
0.589
-0.589
0.589
-0.589
-0.588
0.588
0.587
0.587
-0.587
-0.587
0.587
0.587
-0.586
-0.586
0.585
0.585
0.583
0.583
0.583
-0.582
0.582
-0.582
-0.581
0.581
-0.58
0.578
-0.578
0.578
0.578
0.578
0.577
-0.577
-0.577
0.576
-0.576
-0.576
0.576
0.575
-0.575
0.574
0.574
-0.574
0.573
-0.573
0.573
-0.572
-0.572
0.572
-0.571
-0.571
-0.57
0.57
0.57
0.57
0.569
0.569
0.569
0.568
-0.568
-0.568
0.568
-0.568
-0.568
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
5.36E-01
5.37E-01
5.37E-01
5.37E-01
5.37E-01
5.38E-01
5.38E-01
5.38E-01
5.39E-01
5.39E-01
5.39E-01
5.39E-01
5.40E-01
5.40E-01
5.40E-01
5.40E-01
5.40E-01
5.41E-01
5.41E-01
5.41E-01
5.41E-01
5.41E-01
5.41E-01
5.42E-01
5.42E-01
5.42E-01
5.42E-01
5.42E-01
5.42E-01
5.42E-01
5.43E-01
5.43E-01
5.43E-01
5.43E-01
5.44E-01
5.44E-01
5.44E-01
5.44E-01
5.45E-01
5.45E-01
5.45E-01
5.45E-01
5.45E-01
5.45E-01
5.46E-01
5.46E-01
5.46E-01
5.47E-01
5.47E-01
5.47E-01
5.48E-01
5.48E-01
5.48E-01
5.48E-01
5.49E-01
5.49E-01
5.49E-01
5.49E-01
5.49E-01
5.49E-01
5.49E-01
5.50E-01
5.50E-01
5.50E-01
5.51E-01
5.51E-01
5.51E-01
5.51E-01
5.52E-01
5.52E-01
5.52E-01
5.52E-01
5.53E-01
5.53E-01
5.53E-01
5.53E-01
5.54E-01
5.54E-01
5.54E-01
5.54E-01
5.55E-01
5.55E-01
5.55E-01
5.55E-01
5.55E-01
5.56E-01
5.56E-01
5.56E-01
5.56E-01
5.56E-01
5.56E-01
5.56E-01
5.57E-01
5.57E-01
5.57E-01
5.57E-01
5.57E-01
5.57E-01
5.58E-01
5.58E-01
5.58E-01
5.59E-01
5.59E-01
5.60E-01
5.60E-01
5.60E-01
5.60E-01
5.60E-01
5.61E-01
5.61E-01
5.61E-01
5.62E-01
5.63E-01
5.63E-01
5.63E-01
5.63E-01
5.63E-01
5.64E-01
5.64E-01
5.64E-01
5.64E-01
5.64E-01
5.65E-01
5.65E-01
5.65E-01
5.66E-01
5.66E-01
5.66E-01
5.66E-01
5.66E-01
5.67E-01
5.67E-01
5.67E-01
5.67E-01
5.68E-01
5.68E-01
5.68E-01
5.68E-01
5.69E-01
5.69E-01
5.69E-01
5.69E-01
5.69E-01
5.70E-01
5.70E-01
5.70E-01
5.70E-01
5.70E-01
5.70E-01
5.70E-01
48968
10219
22221
12233
33424
30425
16920
42480
9297
55211
4336
27880
17349
8249
26884
41141
3210
30654
30852
63627
2868
3008
22173
39703
20431
26941
30612
60489
68152
39731
6895
3159
7605
62811
52332
21157
36152
47871
28743
9062
11350
59516
44967
18374
57052
43428
26209
32668
41273
56073
7739
60411
65476
45573
7014
34555
38459
7560
29989
40234
51101
3599
12938
48575
39632
61360
30240
67332
28299
5568
7457
1525
15675
17333
46831
14996
50604
64215
48060
24680
47335
35799
8500
18240
6156
61924
52484
62655
41992
68018
55573
23691
42833
15489
50316
3459
7440
22318
28462
34819
21120
49548
59038
60103
61278
49760
43902
57920
64703
63825
46535
30238
53264
14842
24535
28962
57147
19429
23764
37463
58342
10539
26044
50872
13802
23121
56671
8548
40000
15098
10115
12196
63457
54915
44016
62745
51842
39815
32399
37443
2388
57277
806
26910
49304
52861
2176
8801
44392
60976
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
794
219287
8818
80347
23481
2987
55915
6794
9219
8031
57623
10603
79770
138050
8775
285368
26060
28985
250
4633
26279
8334
25956
169841
8914
1605
7554
873
1244
9578
353132
3459
60686
9055
9240
51427
4810
148753
22980
8493
8471
64081
284339
100129828
284083
56913
4033
26251
6616
10901
654
199713
9117
10423
340980
5915
79644
221301
65003
140699
55312
5604
9476
7266
9154
23412
9552
51029
9647
138716
4919
23242
4363
23071
55510
50855
89941
5316
10018
4313
3954
220042
89858
369
51668
124923
1537
1112
23032
9969
1801
55771
55334
147804
2779
339184
5801
80709
6853
6227
403113
4440
127544
405754
64240
55966
54541
80183
51606
92745
847
119587
55182
8242
25945
171019
131408
120425
4694
10943
64895
11174
26205
9267
29994
9709
153657
2303
314
29904
153733
29785
166785
1258
157922
57460
4205
56925
56061
5439
8674
10113
1238
84337
8629
168417
57018
54903
55269
113829
CALB2
AMER2
DPM2
COASY
PES1
GUK1
LANCL2
STK11
MTA2
NCOA4
ZFAT
SH2B2
TXNDC15
HGSNAT
NAPA
PRRT3
APPL1
MCTS1
ALPP
MYL2
PLA2G2D
HIST1H2AC
SEC31B
ZNF169
TIMELESS
DAG1
ZNF8
CBR1
ABCC2
CDC42BPB
LCE1B
IFNGR1
C14orf93
PRC1
PNMA1
ZNF107
NHS
FAM163A
TCF25
PPM1D
IRS4
PBLD
TMEM145
PCSK7
C17orf47
C1GALT1
LRMP
KCNG2
SNAP25
DHRS4
BMP6
NLRP7
SEC22C
CDIPT
OR52B6
RARB
SRD5A3
FAM26D
MRPL11
MROH8
RFK
MAP2K1
NAPSA
DNAJC7
SLC28A1
COMMD3
SPAG7
DESI2
PPM1F
RPP25L
ROR1
COBL
ABCC1
ERP44
DDX43
PARD6A
RHOT2
PKNOX1
BCL2L11
MMP2
LETM1
C11orf82
SIGLEC12
ARAF
HSPB11
SGK494
CYC1
FOXN3
USP33
MED13
DPH1
PRR11
SLC39A9
TPM3P9
GNAT1
CCDC144NL
PTPRR
AKNA
SYN1
RPS21
MGC71805
MSI1
RNF19B
ERVFRD-1
ABCG5
AJAP1
DDIT4
KIAA0226L
ATP6V1H
SLC38A5
CAT
CPXM2
RNF220
KDM5C
PVRL3
ADAMTS19
FAM131A
AMICA1
NDUFA1
MSL3
PAPOLG
ADAMTS6
GMEB2
CYTH1
BAZ2B
HERPUD1
TTC23L
FOXC2
AOC2
EEF2K
CCDC112
CYP2S1
MMAA
CNGB1
CAMSAP1
PPM1H
MEF2A
LXN
UBFD1
POLR2J
VAMP4
PREB
ACKR2
ELOF1
JRK
ZNF679
CCNL1
MKS1
PSPC1
SLC35A4
-++-++
+---+++-++--+--+
-+-+-+
++-++-----+
+++++++--++
+++++---+-+
+++--+
+-++-+
-+--++
-++?++--+-+
-++----++-+
+++--+
+-+-++
+++--+
+-+-+-+++-+
+--+-+
-+---+
+-+---++--+
---+-+
+---++
+----+
---++--+--+
--++-+
++--++--+--++--+
--+--+
---+++
-----+
--+--+
-+-+++
++---+
-++-++
---?-+
++-+++
+-++-+-+--++--++--+-+
-+++-+-+-+--+--+
+---++
++++-+---++++++-+--++
-+-+++
---+++
++--++
+--+++
--+--+
-+---+
--++-+
-+++++--++-+-+++
+-++-+
+-+--+
--++-+
-----+
-+-+-+
++---+
++--++--+---+-++
++---+
++---+
---+-+
--++++
--++-+
+-++--++-+-+-?++--+++
--+--+
-+-?-+
+-+--+
--++-+-++-+---++
-+-+-+-++-+
+--+-+-+--+
++--++---++
-+---+
++---+
-++++--+++---+-+
+++--+
----++
---+-+++?-+
--++-+
-++--+
--++-+
++--++-++-+
-+---+
-+-+++
-----+
++--+-+-+++
--+--+
-+++---++-+
--++++
--+--+
-+++++----+
+-+--+
+-+----+?-+
--+-++
+------+?+++---+
+-++-+
+++?--+++-+
-++-++
+--+-+
--++-+
--++-+
+-++-++++-+
++-+++-++--+-+-+
++--++++++---+-+
+-+--+
+-+--+
--++++--+--+-+++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
-0.567
-0.567
-0.567
-0.566
-0.566
0.566
-0.565
0.565
0.565
0.565
-0.564
0.564
-0.563
0.562
0.562
-0.562
-0.561
0.561
0.561
0.561
0.56
0.56
0.56
0.559
-0.558
-0.556
0.556
-0.556
0.555
0.555
-0.554
0.554
-0.552
0.552
-0.551
0.551
-0.551
-0.551
-0.551
-0.551
0.55
0.549
0.549
-0.548
0.548
-0.547
-0.546
0.545
0.545
-0.545
0.545
-0.545
0.545
-0.544
-0.544
0.544
0.544
0.543
0.543
0.542
0.542
0.542
-0.542
-0.542
0.541
0.541
0.541
0.541
0.541
-0.54
0.54
-0.54
0.54
0.54
-0.539
0.538
-0.538
-0.538
-0.538
0.537
0.537
-0.536
0.535
0.535
0.534
-0.534
-0.533
-0.533
-0.532
-0.531
-0.531
-0.531
0.531
-0.531
0.531
0.53
0.529
-0.529
-0.528
0.528
0.527
0.527
0.527
-0.526
-0.526
0.526
0.526
0.526
0.526
-0.525
0.524
0.524
0.523
-0.522
0.522
0.522
-0.52
-0.52
0.52
0.52
-0.52
-0.519
-0.518
0.518
0.516
0.516
0.515
-0.515
0.515
-0.514
0.514
-0.514
0.513
0.512
-0.512
0.512
0.512
-0.511
0.51
0.51
-0.51
0.51
-0.51
0.509
0.509
0.509
-0.508
-0.508
-0.508
0.508
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
5.71E-01
5.71E-01
5.71E-01
5.71E-01
5.71E-01
5.72E-01
5.72E-01
5.72E-01
5.72E-01
5.72E-01
5.73E-01
5.73E-01
5.74E-01
5.74E-01
5.74E-01
5.74E-01
5.75E-01
5.75E-01
5.75E-01
5.75E-01
5.75E-01
5.75E-01
5.76E-01
5.76E-01
5.77E-01
5.78E-01
5.78E-01
5.78E-01
5.79E-01
5.79E-01
5.80E-01
5.80E-01
5.81E-01
5.81E-01
5.81E-01
5.82E-01
5.82E-01
5.82E-01
5.82E-01
5.82E-01
5.82E-01
5.83E-01
5.83E-01
5.84E-01
5.84E-01
5.84E-01
5.85E-01
5.86E-01
5.86E-01
5.86E-01
5.86E-01
5.86E-01
5.86E-01
5.86E-01
5.86E-01
5.86E-01
5.86E-01
5.87E-01
5.87E-01
5.88E-01
5.88E-01
5.88E-01
5.88E-01
5.88E-01
5.88E-01
5.88E-01
5.88E-01
5.89E-01
5.89E-01
5.89E-01
5.89E-01
5.89E-01
5.89E-01
5.89E-01
5.90E-01
5.90E-01
5.91E-01
5.91E-01
5.91E-01
5.91E-01
5.92E-01
5.92E-01
5.93E-01
5.93E-01
5.93E-01
5.93E-01
5.94E-01
5.94E-01
5.95E-01
5.95E-01
5.95E-01
5.95E-01
5.95E-01
5.96E-01
5.96E-01
5.96E-01
5.97E-01
5.97E-01
5.97E-01
5.98E-01
5.98E-01
5.98E-01
5.98E-01
5.99E-01
5.99E-01
5.99E-01
5.99E-01
5.99E-01
5.99E-01
6.00E-01
6.00E-01
6.01E-01
6.01E-01
6.02E-01
6.02E-01
6.02E-01
6.03E-01
6.03E-01
6.03E-01
6.03E-01
6.03E-01
6.04E-01
6.05E-01
6.05E-01
6.06E-01
6.06E-01
6.06E-01
6.07E-01
6.07E-01
6.07E-01
6.08E-01
6.08E-01
6.08E-01
6.09E-01
6.09E-01
6.09E-01
6.09E-01
6.09E-01
6.10E-01
6.10E-01
6.10E-01
6.10E-01
6.10E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
65336
67280
55345
1192
13017
42867
62389
63777
64560
1995
52744
54168
54415
14443
53631
31464
18703
15748
47116
32649
57807
14445
26354
40513
53693
30219
33802
25335
47001
67645
65917
26159
64689
38260
37825
17182
27907
5438
7848
16910
33387
61053
44842
48054
21624
49657
7835
1795
22291
59604
5658
25607
45904
2828
15952
54478
4558
5370
19285
60647
67639
36382
18851
30548
51964
49842
22853
17703
64971
68527
39439
41633
60936
5814
62835
65607
67848
26481
50487
50731
19856
63332
40774
51647
57472
26379
7790
32092
65797
641
7898
13758
19824
40347
10
23640
38579
15744
2024
20373
14635
10192
53551
58240
34011
31606
65319
54403
30805
65299
1550
54687
4449
57531
53765
5786
17105
44301
7499
53466
7136
33450
4161
3750
21369
18428
20688
39604
58545
1692
67016
67366
40435
17330
41925
46010
47193
31341
23292
61223
44239
46581
46038
6854
37308
60065
34962
50596
40888
28194
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
89958
53339
55839
10535
171389
7410
85320
79969
79591
65078
51128
7132
158399
79894
27069
10320
51449
9172
11184
10262
93973
11153
54997
1068
9014
147841
440435
140901
7471
83590
8641
83549
7166
9575
10640
11161
8633
55257
54498
55744
134353
9066
5305
284424
283767
1814
11266
64359
55159
6383
122742
23629
55785
22818
118487
28964
57492
338879
27161
4074
6386
25836
26284
988
57657
1917
6654
10488
55647
50839
51232
7381
5452
80228
203
400223
147808
23272
51084
3669
57547
8851
3060
9703
10560
84851
8971
54805
29944
64090
140838
201627
653857
80777
8649
140700
1084
79142
474338
284361
54627
26148
124590
95
6677
22834
22934
5991
130535
57715
83479
975
9962
154881
2702
26521
9266
27036
56945
11154
3622
63943
285203
27068
10725
55048
100129828
57486
2962
11190
7216
89790
5881
6601
11128
285349
84893
128653
84945
55256
7164
133584
9443
10159
9778
283130
10489
8841
157773
27297
SAPCD2
BTBD1
CENPN
RNASEH2A
NLRP6
VAV2
ABCC11
ATAT1
C10orf76
RTN4R
SAR1B
TNFRSF1A
ZNF483
ZNF672
GHITM
IKZF1
PCYOX1
MYOM2
MAP4K1
SF3B4
ACTR8
FICD
TESC
CETN1
TAF1B
SPC24
GPR179
STK35
WNT1
TMUB1
PCDHGB4
UCK1
TPH1
CLOCK
EXOC5
C14orf1
UNC5C
MRGBP
SMOX
COA1
LSM11
SYT7
PIP4K2A
MIR7-3HG
GOLGA6L1
DRD3
DUSP12
NXN
RFWD3
SDC2
OR4L1
BRD7P3
FGD6
COPZ1
CHCHD1
GIT1
ARID1B
RNASE10
AGO2
M6PR
SDCBP
NIPBL
ERAL1
CDC5L
HCN3
EEF1A2
SOS1
CREB3
RAB20
TAS2R10
CRIM1
UQCRB
POU2F2
ORAI2
AK1
C14orf181
ZNF784
FAM208A
CRYL1
ISG20
ZNF624
CDK5R1
HCRT
KIAA0100
SLC19A2
TRIM52
H1FX
CNNM2
PNMA3
GAL3ST2
NANP
DENND6A
ACTR3C
CYB5B
LAMTOR3
SAMD10
CEACAM3
PHF23
SUMO1P3
EMC10
MAP10
C10orf12
USH1G
ACY1
SPAM1
ZNF652
RPIA
RFX3
KCTD18
SEMA4G
DDX59
CD81
SLC23A2
KCTD7
GJA5
TIMM8B
CYTH2
SIGLEC7
MRPS22
AP4S1
ING2
FKBPL
EOGT
PPA2
NFAT5
VPS37C
C10orf91
NLN
GTF2F1
CEP250
TRO
SIGLEC10
RAC3
SMARCC2
POLR3A
ZNF660
FBXO18
C20orf141
ABHD13
ADI1
TPD52L1
EGFLAM
MED7
ATP6AP2
KIAA0232
SLC25A45
LRRC41
HDAC3
C8orf48
CRCP
+-+--+
+-++--++--+
--++-+
-+++-+---++
-+++------+
++-+++
---+-+
-++--+++--+
-+-++-+-+-+
--++--+-++++--++
----++
++---+
---+-+
---+-+
++-+-+
++-++++-+-+
--++-+
--+++---+++
+-++-+
++--+-+-+-+
-++---+---+
-+-+++++--+-++---+?-+
+--+++
---+++
++-++--++++
---+-+
+----+
++-++---+++
+++++--++-+
--+-++
-+---+
-----+
-+++---+-++
--++-+
--+++-+--++
--++-+
-+---+
----++
+++?+++-++---+++
+-+--+-++--+-+++
+-++-++-+++--+-++-++---+++
++++-+
++-+---++-+
+-++-++-+++
+++--+
++-+++-+--+-+--+
+--+++--+-+
-+-?++++----++-+
+----+
+-+--+
+-++---++-+
++--++
---+-+
+--+-+
+-++--+++++-+?-+
+++--+--+-+
+-++--+--++-+--+
--++-+
+-+-+-++--+
--+-++
+-+-+++-++-+---+
---?++
+++---++-++---++-++-+
---++--+--+
++-?-+
--+--+
---+-+
-+++-+
---+++
+-+-++
+-++-+
---+++
+-++++-+?--+-+-+
+++--+
--+?-+
++++++-+--+
--+++--+--+
++-+-+
+--+-+
+----+
+-+-++
-+-+-++-+-+
-+-+-+
-+--+-+--++
-+--++
+-++++
+-++-+
+-+--+-++-+
--+-+--++-+
+-++-+
-----+
---+-+
-----+
++-+-+
---+++
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
0.508
-0.509
-0.508
-0.508
-0.508
0.508
0.508
-0.508
0.507
-0.506
-0.506
-0.506
-0.506
0.505
-0.505
0.503
0.503
-0.502
-0.502
-0.501
0.501
0.5
0.5
0.499
-0.499
0.498
0.498
0.498
0.498
0.497
-0.496
-0.496
-0.496
-0.496
-0.495
0.495
0.495
-0.494
-0.494
-0.494
-0.494
0.493
0.493
-0.492
0.492
0.491
-0.491
-0.49
-0.49
-0.49
-0.49
-0.489
0.489
-0.488
0.488
-0.488
-0.488
0.487
0.487
0.487
-0.486
-0.485
0.484
0.484
0.484
-0.483
0.481
0.481
0.48
-0.48
0.48
-0.479
0.479
0.478
-0.478
-0.477
0.477
0.477
0.476
-0.476
-0.476
0.476
-0.476
0.475
-0.476
-0.475
0.475
0.475
0.475
-0.475
0.474
0.474
-0.474
0.473
0.473
-0.473
-0.473
0.472
0.471
0.468
-0.468
-0.467
0.466
-0.465
-0.465
-0.465
-0.465
-0.464
-0.464
-0.464
-0.463
-0.463
-0.463
0.462
0.462
-0.462
0.462
-0.462
0.461
0.461
0.461
-0.461
0.46
-0.46
0.459
0.459
0.459
-0.459
0.459
-0.458
-0.458
0.458
-0.458
-0.457
-0.456
0.456
-0.455
0.455
0.455
0.455
-0.454
0.454
-0.454
-0.453
0.453
-0.452
-0.452
-0.452
0.451
0.45
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.11E-01
6.12E-01
6.13E-01
6.13E-01
6.13E-01
6.13E-01
6.14E-01
6.14E-01
6.15E-01
6.15E-01
6.16E-01
6.16E-01
6.16E-01
6.17E-01
6.17E-01
6.17E-01
6.18E-01
6.18E-01
6.18E-01
6.19E-01
6.19E-01
6.19E-01
6.19E-01
6.20E-01
6.20E-01
6.20E-01
6.20E-01
6.20E-01
6.21E-01
6.21E-01
6.21E-01
6.21E-01
6.21E-01
6.22E-01
6.22E-01
6.22E-01
6.22E-01
6.23E-01
6.23E-01
6.23E-01
6.24E-01
6.24E-01
6.24E-01
6.24E-01
6.25E-01
6.25E-01
6.25E-01
6.26E-01
6.26E-01
6.26E-01
6.26E-01
6.26E-01
6.27E-01
6.27E-01
6.27E-01
6.28E-01
6.28E-01
6.29E-01
6.29E-01
6.31E-01
6.31E-01
6.31E-01
6.31E-01
6.32E-01
6.32E-01
6.32E-01
6.33E-01
6.33E-01
6.33E-01
6.33E-01
6.33E-01
6.34E-01
6.34E-01
6.34E-01
6.34E-01
6.34E-01
6.34E-01
6.34E-01
6.35E-01
6.35E-01
6.35E-01
6.35E-01
6.35E-01
6.35E-01
6.36E-01
6.36E-01
6.36E-01
6.36E-01
6.36E-01
6.36E-01
6.37E-01
6.38E-01
6.40E-01
6.40E-01
6.41E-01
6.41E-01
6.42E-01
6.42E-01
6.42E-01
6.42E-01
6.42E-01
6.42E-01
6.43E-01
6.43E-01
6.43E-01
6.44E-01
6.44E-01
6.44E-01
6.44E-01
6.44E-01
6.44E-01
6.45E-01
6.45E-01
6.45E-01
6.45E-01
6.46E-01
6.46E-01
6.46E-01
6.46E-01
6.46E-01
6.47E-01
6.47E-01
6.47E-01
6.47E-01
6.47E-01
6.47E-01
6.47E-01
6.49E-01
6.49E-01
6.49E-01
6.49E-01
6.49E-01
6.49E-01
6.50E-01
6.50E-01
6.50E-01
6.50E-01
6.51E-01
6.51E-01
6.51E-01
6.51E-01
6.52E-01
6.53E-01
47118
8408
18622
3460
63745
25170
68134
57282
20754
28355
20047
21767
64884
12745
51372
10675
27859
399
53776
62877
20835
58180
32751
39722
6691
61727
21988
10698
64257
33194
4338
945
37167
63941
18884
50347
33302
2806
10110
2495
6395
67789
36207
24359
59083
30878
29967
29703
60377
63694
21585
6952
30757
61160
64557
10026
58078
33575
8021
52374
44804
52966
44118
65267
51208
20878
34009
32010
46051
37391
58787
68224
28370
47427
66311
21598
14189
66226
44432
66498
41204
50835
13372
14883
56511
18827
20973
17672
68167
46614
37505
59664
11781
38094
63590
33169
39557
57271
42318
14967
48598
60286
65041
16667
24121
25046
31140
64837
57438
57499
61477
62021
37608
40346
29478
40286
12408
7452
2637
34621
27825
54305
23085
41376
22531
37107
4000
4408
18037
42349
38201
19988
11154
63422
8251
1868
1456
21150
15071
54147
4485
43491
8571
22232
44624
13149
6569
32631
40232
6565
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
100132476
3476
51714
112885
4659
64175
6612
7126
398
339524
26517
2937
84790
54777
255324
23335
11136
391257
5861
51184
144348
1822
9990
5378
23225
10815
7419
286464
166379
440556
2919
51023
29923
65999
57610
657
81614
284325
10776
60625
64319
26035
390082
6608
84342
4828
10446
6373
79723
7673
56942
11279
375323
420
65991
9784
10498
275
5715
25932
3344
160857
60481
9592
146330
23358
84826
51252
399669
5412
23649
83715
9014
10747
80115
7701
1282
2104
282969
25970
51534
54764
10814
55689
6018
147912
83695
9244
168544
2329
57115
9967
7780
343990
57332
100129828
54093
79980
5763
55716
3080
5970
5089
94241
338657
79703
3990
4792
81537
84299
6003
259230
6820
10787
55650
81894
84958
254394
11238
6747
2983
54926
2348
167465
7043
51397
51377
55336
3203
55734
133
54914
57639
94239
51514
3444
9132
27284
8350
5213
9620
171169
51442
161497
23462
54626
9464
4722
10844
8736
KRTAP4-7
IGBP1
SELT
PHF21B
PPP1R12A
LEPRE1
SUMO3
TNFAIP1
ARHGDIG
LINC01140
TIMM13
GSS
TUBA1C
TTC40
EPGN
WDR7
SLC7A9
SUMO1P1
RAB1A
GPN3
ZNF664
ATN1
SLC12A6
PMS1
NUP210
CPLX1
VDAC3
CHDC2
BBS12
LINC00982
CXCL1
MRPS18C
HILPDA
LRRC61
RANBP10
BMPR1A
NIPA2
C19orf54
ARPP19
DHX35
FBRS
GLCE
OR52E5
SMO
COG8
NMB
LRRN2
CXCL11
SUV39H2
ZNF222
CMC2
KLF8
LHFPL4
ART4
FUNDC2
SNX17
CARM1
AMT
PSMD9
CLIC4
FOXN2
CCDC122
ELOVL5
IER2
FBXL16
USP24
SFT2D3
FAM178B
ZNF816-ZNF321P
UBL3
POLA2
ESPN
TAF1B
MASP2
BAIAP2L2
ZNF142
COL4A1
ESRRG
FUOM
SH2B1
VTA1
ZRANB1
CPLX2
YEATS2
RLF
SIX5
RHNO1
CRLF1
ZNF467
FMO4
PGLYRP4
THRAP3
SLC30A2
KIAA1211L
CBX8
NCRNA00173
SETD4
DSN1
PTMS
LMBR1L
CFHR2
RELA
PBX2
TP53INP1
CCDC84
C11orf80
LIPC
NFKBIA
SGPP1
MIEN1
RGS13
SGMS1
SULT2B1
NCKAP1
PIGV
SLC25A28
SYTL1
MCM9
CA5B
SSR3
GUCY1B3
UBE2R2
FOLR1
ZNF366
TGFB3
COMMD10
UCHL5
FBXL8
HOXA6
ZFP64
ADM
FOCAD
CCDC146
H2AFV
DTL
IFNA7
KCNQ4
SULT1B1
HIST1H3A
PFKM
CELSR1
SPACA4
VGLL1
STRC
HEY1
HES2
HAND2
NDUFS3
TUBGCP2
MYOM1
-+++++
--++-+
+-+-----+-+
+-+?-+--+-+
----++
--+--+
++-+-+
-+---+
++-+--+---+
-+-++++-+-+
--+--+
+--+++
+--+-+
+-+++--+-++-++++++--+--?-+
+-++-+
+++--++---+
-+-+++
---+++
--++-+
+---++
+---++
+++--+
--++++-+--+
-----+
++-?++---++
+---++
--+--+
++--+-+--++-+--+
+-+?-+
-+--++
+-++---++-+
---+-+
----++
-++?-+
++++++-++-+
++-++--++-+
++---+
+---++++-+-+-+++
++--+-+---+
+-+-++
+++--+-+--+
-++?++-+--+
+++--+
+----+
++-?+---+-+
-+-+++---++-+-++
-+-+++
++--+--+?++
----+++--+-+---+
--++-+
+-+--+
--+++-+---+
--+++-++++--+++-----+
--+--+
+----+
+---++
-+++++-+--+
+--?+-+-+++
+-+-++--?+--++-+
--++-+
++-?-+
--+++-+++-++-++-+-+-+
+++++-+-+-+
++++-+-+--++--+--++++
-+-+--+---+
--+--+
+----+
+++-++--+++
--++-+
+--++-+-+-+
---+-+
++---+
+-++-+---++
++-+-+++-++++?--+---+
-+++-+
----++
--++++-+?+++-+-+++--+
-----+
+-+--+--+-+
+-++-+++--+
++-+++--++-++--+
--++++----+
+--+-+
--+--+
++---+
--+-++
---+++
+--?-+
++---+
+++-+---+++
-+---+
+----+
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
6376
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
0.45
-0.449
0.449
-0.449
-0.449
0.449
-0.448
-0.448
0.447
-0.446
-0.446
-0.446
-0.446
0.445
-0.445
0.445
-0.445
0.445
0.444
-0.443
-0.443
-0.443
0.443
-0.443
-0.443
0.443
-0.441
0.44
0.44
0.44
-0.439
0.439
0.439
-0.439
0.439
0.438
-0.437
0.437
-0.437
-0.437
0.437
0.436
0.436
0.436
-0.434
0.433
0.433
0.432
-0.432
-0.432
0.432
-0.431
-0.431
-0.431
-0.431
0.43
-0.43
-0.43
0.429
0.429
0.429
-0.429
0.429
-0.429
-0.428
-0.428
-0.428
-0.427
-0.427
0.426
-0.426
-0.426
0.425
-0.425
-0.425
0.424
0.424
-0.424
-0.424
-0.424
-0.423
0.422
-0.422
-0.422
0.421
0.42
-0.419
0.419
0.418
0.418
0.418
0.417
0.417
0.417
0.416
0.416
0.416
-0.416
0.416
0.415
0.415
0.414
-0.414
-0.414
-0.413
0.413
-0.412
0.412
0.412
-0.412
0.411
0.411
0.41
-0.408
-0.407
-0.406
0.406
-0.405
-0.405
0.405
0.405
0.405
0.404
0.404
-0.404
-0.403
-0.402
-0.403
0.402
-0.402
0.401
0.401
0.401
0.399
0.399
0.399
0.399
0.398
0.398
-0.398
0.397
0.397
0.395
-0.395
0.395
-0.394
0.394
-0.394
-0.393
-0.393
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
6.53E-01
6.53E-01
6.53E-01
6.53E-01
6.53E-01
6.54E-01
6.54E-01
6.54E-01
6.55E-01
6.55E-01
6.56E-01
6.56E-01
6.56E-01
6.56E-01
6.56E-01
6.56E-01
6.56E-01
6.57E-01
6.57E-01
6.58E-01
6.58E-01
6.58E-01
6.58E-01
6.58E-01
6.58E-01
6.58E-01
6.59E-01
6.60E-01
6.60E-01
6.60E-01
6.61E-01
6.61E-01
6.61E-01
6.61E-01
6.61E-01
6.62E-01
6.62E-01
6.62E-01
6.62E-01
6.62E-01
6.62E-01
6.63E-01
6.63E-01
6.63E-01
6.64E-01
6.65E-01
6.65E-01
6.65E-01
6.65E-01
6.66E-01
6.66E-01
6.66E-01
6.66E-01
6.66E-01
6.66E-01
6.67E-01
6.67E-01
6.67E-01
6.68E-01
6.68E-01
6.68E-01
6.68E-01
6.68E-01
6.68E-01
6.68E-01
6.68E-01
6.68E-01
6.69E-01
6.69E-01
6.70E-01
6.70E-01
6.70E-01
6.71E-01
6.71E-01
6.71E-01
6.71E-01
6.71E-01
6.72E-01
6.72E-01
6.72E-01
6.72E-01
6.73E-01
6.73E-01
6.73E-01
6.73E-01
6.75E-01
6.75E-01
6.75E-01
6.76E-01
6.76E-01
6.76E-01
6.77E-01
6.77E-01
6.77E-01
6.77E-01
6.78E-01
6.78E-01
6.78E-01
6.78E-01
6.78E-01
6.78E-01
6.79E-01
6.79E-01
6.79E-01
6.80E-01
6.80E-01
6.80E-01
6.80E-01
6.81E-01
6.81E-01
6.81E-01
6.81E-01
6.82E-01
6.83E-01
6.84E-01
6.85E-01
6.85E-01
6.85E-01
6.85E-01
6.85E-01
6.86E-01
6.86E-01
6.86E-01
6.86E-01
6.87E-01
6.87E-01
6.87E-01
6.87E-01
6.88E-01
6.88E-01
6.88E-01
6.88E-01
6.89E-01
6.90E-01
6.90E-01
6.90E-01
6.90E-01
6.90E-01
6.90E-01
6.91E-01
6.91E-01
6.92E-01
6.93E-01
6.93E-01
6.93E-01
6.93E-01
6.94E-01
6.94E-01
6.94E-01
6.94E-01
64559
12482
611
40783
54612
48251
67367
20116
54879
20223
14474
26384
64698
18983
23976
8481
28916
8845
39526
58275
38375
38457
27476
29611
40365
197
6373
53406
15123
57491
281
42869
56821
33954
36316
50113
66672
60736
19565
3083
51466
65010
27220
61176
47127
55315
24490
21079
41232
26230
37869
57974
14006
27324
68544
68239
40881
22712
32660
9873
46643
67442
58950
26553
22523
59337
46360
16562
30155
26263
19956
20088
27036
48525
66397
17787
46617
63665
29297
67546
10109
16665
38837
52089
24181
60737
21008
24509
20752
39702
11697
18265
12976
26535
9483
21155
45819
64853
8030
8879
58307
780
57071
51612
2908
46701
27797
26886
64437
3679
53355
36168
31347
54972
47450
48834
11157
67785
54545
2907
47558
3078
4630
48769
855
8649
19693
62370
1629
4295
46486
19734
2588
9780
11086
18486
21708
42995
50228
67419
2084
7243
53635
50714
29786
344
62462
11986
33137
30245
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
79020
3630
57585
722
114823
440275
253714
8266
257236
4849
5683
3792
5025
9187
2125
5306
8824
9122
6521
79086
84284
5520
81542
5303
9020
144360
9857
10140
283377
79751
151246
23383
4124
9110
79576
3141
2888
80255
55911
3561
10588
60492
8402
25865
157848
8636
83475
5203
5015
5573
667
79658
255783
4292
10742
122809
80781
503542
162427
23423
100129828
1519
23389
5972
2589
23258
53407
140432
9477
8854
256949
23189
140459
8045
7932
6400
4137
661
3887
11257
115353
7739
5204
51251
144108
63893
256236
2241
56905
22938
79002
56987
3467
2864
5738
55837
7403
55811
9181
51517
64787
116254
55220
84272
29980
64478
8563
79767
55069
55238
445582
6448
9092
143888
6603
23590
10084
84182
259234
6518
3489
2631
285613
79646
56001
55707
6455
23341
201305
56681
29934
4756
51234
143684
266971
983
29954
58506
83606
466
5867
1657
51706
3290
83648
221785
54958
9831
133383
163154
C7orf25
INS
CRAMP1L
C4BPA
LENG8
EIF2AK4
MMS22L
UBL4A
CCDC96
CNOT3
PSMA2
KEL
P2RX4
SLC24A1
EVPL
PITPNA
CES2
SLC16A4
SLC4A1
SMIM7
NTPCR
PPP2R2A
TMX1
PIN4
MAP3K14
LINC00477
CEP350
TOB1
SPRYD4
SLC25A22
SGOL2
MAU2
MAN2A1
MTMR4
NKAP
HLCS
GRB14
SLC35F5
APOBR
IL2RG
MTHFS
CCDC90B
SLC25A11
PRKD2
NKX6-3
SSNA1
DOHH
PFDN4
OTX2
PRKAR1A
DST
ARHGAP10
PRR24
MLH1
RAI2
SOCS4
COL18A1
SPRN
FAM134C
TMED3
NCRNA00115
CTSO
MED13L
REN
GALNT1
DENND5A
STX18
RNF113B
MED20
ALDH1A2
KANK3
KANK1
ASB6
RASSF7
OR2H2
SEL1L
MAPT
POLR3D
KRT81
TP53TG1
LRRC42
ZNF185
PFDN5
NT5C3A
SPTY2D1
UBE2O
NAPSB
FER
C15orf39
SNW1
C19orf43
BBX
IFNW1
FFAR1
PTGFRN
EAPP
KDM6A
ADCY10
ARHGEF2
NCKIPSD
EPS8L2
GINM1
KLHDC8A
YIPF4
DONSON
CSMD1
THOC5
ELMO3
TMEM248
SLC38A7
POTEE
SGSH
SART1
KDELC2
SMARCD2
PDSS1
PQBP1
FAM188B
DSCR10
SLC2A5
IGFBP6
GBAS
RELL2
PANK3
NXF2
NECAP2
SH3GL1
DNAJC16
SPNS3
SAR1A
SNX12
NEO1
EMC4
FAM76B
PIPSL
CDK1
POMT2
SCAF1
GUCD1
ATF1
RAB4A
DMXL1
CYB5R1
HSD11B1
FAM167A
ZSCAN25
TMEM160
ZNF623
SETD9
PRR22
+-+--+
+-+-+++--++
+----+
+-+--+
+++--+
-+++-++--+--++++
++---+
--+++++-++---+-+
++--+++---+
+-+---+-+++
--+-++
++-++--++-+
---+-+
-++--+
--++++
-----+
++---+
-+---+
++++-+----++---+
-+-+++---+-----+
+-++---+--+
--++-+---++
++++++-++-+
+++--++-+-+
+-+--+-+++--++-+
+++--+
+++--+
+----+
--+--+
+---+-++-++
+-+--+
++--+-+---+
-+---+
---+-+
-+-+++-++---+--+
+-+--+----+
---+-+
-----+
--++-+-+--+
-+++++
--++++-++-+
--++++
-++----++-+
-+-+----+++
+---++
+----+
++-+++
-+++-+-+---++--+
-+++--+-++++-+-+--+-+
+-++--+-++++++++++++++-?+-++--+
++++-+++----++---++-+
-+-+-+
++--++
++++++---++
+-++-+-++---++-+
-+---+
+-+-++
++--+--+-+--++-+
--+--+
+----+
+-+--+
+-+--+
+-++-+
--++-+
-++--+
++++-++--++
-++-++
+----+
++-?-+
--++++
--+--+
----++
+---++
----++
-----+
--+--+
++---+
+-++++++-+---+++
++++-+-+---+-+-+
+-++-+
---+-+
++++----+++
--+++-++++-+++++
---+-+
++-+-+
++-+++-+--+
+-++-+++-++-++--+-+-+
----++
--++-+
-+-+++----+
--+++-----+
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
6376
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
7257
0.393
-0.392
0.392
-0.39
-0.39
0.388
-0.386
-0.386
0.385
0.385
0.385
0.384
0.384
-0.384
0.384
-0.384
0.384
0.384
0.383
0.383
-0.382
-0.382
-0.382
-0.382
-0.381
-0.381
0.379
-0.379
-0.378
-0.378
-0.377
-0.377
0.377
0.377
-0.376
0.376
0.376
0.375
0.375
0.374
0.374
-0.374
0.373
0.373
0.373
-0.372
-0.372
-0.371
0.371
0.37
0.37
0.37
-0.369
0.369
-0.368
-0.368
-0.368
0.367
0.367
-0.367
0.366
-0.366
-0.366
0.365
-0.365
-0.365
0.365
-0.364
0.364
-0.364
0.364
0.363
0.362
0.362
-0.362
-0.361
0.361
-0.361
0.361
0.36
0.36
-0.359
0.359
-0.358
0.358
0.358
-0.357
-0.357
-0.356
0.355
-0.355
-0.355
0.355
0.354
-0.354
0.354
-0.354
-0.354
-0.352
0.352
-0.352
-0.351
-0.351
-0.351
0.35
0.349
-0.349
0.349
0.348
0.348
-0.348
0.348
-0.348
0.348
0.348
-0.347
-0.347
-0.347
-0.347
-0.346
0.346
-0.346
0.346
-0.346
-0.345
-0.345
-0.345
-0.343
-0.343
0.343
-0.343
-0.343
0.343
-0.342
-0.342
0.342
0.341
0.341
0.341
-0.34
-0.34
-0.339
-0.34
0.339
0.339
0.339
0.339
-0.339
0.338
-0.338
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
6.95E-01
6.95E-01
6.95E-01
6.96E-01
6.97E-01
6.98E-01
6.99E-01
6.99E-01
7.00E-01
7.00E-01
7.01E-01
7.01E-01
7.01E-01
7.01E-01
7.01E-01
7.01E-01
7.01E-01
7.01E-01
7.02E-01
7.02E-01
7.02E-01
7.02E-01
7.03E-01
7.03E-01
7.03E-01
7.04E-01
7.05E-01
7.05E-01
7.05E-01
7.05E-01
7.06E-01
7.06E-01
7.06E-01
7.07E-01
7.07E-01
7.07E-01
7.07E-01
7.08E-01
7.08E-01
7.08E-01
7.08E-01
7.08E-01
7.09E-01
7.09E-01
7.10E-01
7.10E-01
7.10E-01
7.10E-01
7.11E-01
7.11E-01
7.12E-01
7.12E-01
7.12E-01
7.12E-01
7.13E-01
7.13E-01
7.13E-01
7.13E-01
7.14E-01
7.14E-01
7.14E-01
7.14E-01
7.15E-01
7.15E-01
7.15E-01
7.15E-01
7.15E-01
7.16E-01
7.16E-01
7.16E-01
7.16E-01
7.16E-01
7.17E-01
7.17E-01
7.17E-01
7.18E-01
7.18E-01
7.18E-01
7.18E-01
7.19E-01
7.19E-01
7.20E-01
7.20E-01
7.20E-01
7.20E-01
7.21E-01
7.21E-01
7.21E-01
7.22E-01
7.22E-01
7.23E-01
7.23E-01
7.23E-01
7.23E-01
7.23E-01
7.23E-01
7.24E-01
7.24E-01
7.25E-01
7.25E-01
7.25E-01
7.25E-01
7.25E-01
7.26E-01
7.27E-01
7.27E-01
7.27E-01
7.27E-01
7.28E-01
7.28E-01
7.28E-01
7.28E-01
7.28E-01
7.28E-01
7.28E-01
7.28E-01
7.28E-01
7.29E-01
7.29E-01
7.29E-01
7.29E-01
7.29E-01
7.29E-01
7.30E-01
7.30E-01
7.30E-01
7.30E-01
7.31E-01
7.32E-01
7.32E-01
7.32E-01
7.32E-01
7.32E-01
7.32E-01
7.32E-01
7.33E-01
7.33E-01
7.33E-01
7.33E-01
7.34E-01
7.34E-01
7.34E-01
7.34E-01
7.34E-01
7.35E-01
7.35E-01
7.35E-01
7.35E-01
7.35E-01
7.35E-01
29907
27368
8161
38203
4774
63851
65658
18726
23366
25377
10477
56403
16757
65060
9681
18937
62319
10715
37379
56703
30500
15478
64021
13705
11094
26268
39111
3110
46696
23473
57576
61512
52778
7746
1797
59800
38940
61198
6892
56410
48314
63980
62770
35004
8922
22826
16114
56049
50106
22356
40647
12293
52935
64090
3144
56336
6469
12445
6555
67934
28964
15908
28249
16247
50500
6559
61111
62898
42624
41927
59100
29610
26387
50598
32152
5269
18797
38644
68164
18078
51151
40459
68553
1667
46653
17759
35378
12296
20263
58468
29376
34085
44186
24781
27989
63940
61181
30792
3016
16889
7329
20966
25667
17727
35298
62756
55339
64447
25697
20469
30815
43646
38900
15040
49101
25236
59768
14469
62340
22052
9665
45374
59971
3783
42649
2948
25806
37132
35187
18802
44549
19260
24414
22574
31097
18836
43712
11771
68221
1704
50173
17830
20933
21807
40935
60423
50180
35891
42369
44590
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
n
84657
5184
4204
5828
83897
7265
957
563
132320
130
6047
55295
51086
9028
84080
83737
2674
27341
123355
80127
81832
81603
6421
79096
549
3709
80185
166336
3633
595
83659
57571
440465
54993
6347
6695
10587
9633
200539
57619
7766
79714
7349
150274
100129828
2022
57093
147015
3818
84168
28978
10733
83544
5998
8911
79033
63877
54206
10713
10794
23759
543

supplementary figures - QIMR Genetic Epidemiology

Transcription

Similar documents

Evolution of a Clinical Research Informatics Group within a Service

Famicompo Creators

Source Master List Sorted By Company Name

Die BUCHSTAVIER - Das Dosierte Leben