Batches of Scratches: Pediatric Skin Patches
Transcription
Batches of Scratches: Pediatric Skin Patches
Batches of Scratches: Pediatric Skin Patches Adapted for the Pediatric Nurse Practitioner and Advanced Practice Nurse Pediatric Focus Conference November 5, 2014 By Dr. Jane Chevako Cutaneous Fungal Infections: 1. Dermatophytes: Tinea 2. Candida Tinea Corporis: Ringworm Tinea Pedis: Athlete’s Foot “Sweaty Sock Dermatitis” Tinea Cruris: Jock Itch Tinea Skin Infections Apply topical antifungal BID: Clortrimazole Cream (Lotrimin®) Miconazole (Monostat®, Lotrimin® Spray) Terbenafine (Lamisil®) Tolnaftate (Tinactin ®) RX: Ketoconazole, Spectazole Do NOT use Nystatin ***TREAT FOR 2-3 WEEKS*** Patient & Family Instructions: Apply an antifungal until the rash is completely gone PLUS 3-7 more days. Tinea Scalp Infections Needs oral antifungals for tinea capitis and adult face: Griseofulvin® • 20-25 mg/kg/d for 6-8 weeks Fluconazole (Diflucan®) TREAT FOR 6-8+ WEEKS Kerion: Marked inflammatory response Can lead to scarring alopecia Add oral corticosteroids: • 0.5-1 mg/kg/d for 2-4 weeks, wean Add oral antibiotics if significant crusting or positive skin culture Candida Infection Candidiasis in diaper area: Widespread vivid red erythema Raised edge, sharp margins White scales at the boarders Pinpoint satellite lesions Spares intertriginous areas Topical antifungal: OTC antifungal lotrimin or miconazole: 2 times a day Do NOT use terbinafine or tolnaftate Nystatin Rx: effective, must be applied 3-4 times/day Ketoconazole Rx: 2 times a day helps compliance Viral Exanthum: Treat Symptoms Coxsackie: Hand, Foot and Mouth Symptomatic Treatment: Antihistamine, like Diphenhydramine (Benadryl®) mixed 1:1 with an oral antacid • 1 mg/kg/dose diphenhydramine divided every 6-8 hours. • More Sleepy: Swish and swallow. • Less Sleepy: Swish and spit. Analgesics for pain. Eczematous Eruptions Atopic Dermatitis Nummular Eczema Seborrheic Dermatitis Contact Dermatitis Primary Irritant Dermatitis Allergic Contact Dermatitis Atopic Dermatitis: The most common cause of eczema in children PRURITIS Dryness Sites of predilection Infant: face 8-10 m/o: extensor surfaces of arms and legs Children, teens and adults: face; neck; antecubital and popliteal fossae Atopic Dermatitis Atopic Pleats extra grooves to lower eye lids Long, luxurious eyelashes Pallor of buccal and paranasal areas Atopic Dermatitis Pruritis, the feeling of “itch,” leads to scratching Scratching leads to skin trauma and “spreading” itch “Itch-scratch-itch” cycle Atopic Dermatitis: Itch Comes First Reduce the ITCH: Antihistamine Loratadine, cetirizine, fexofenadine • Only need to give every 12-24 hours Diphenhydramine (Benadryl®) • 1 mg/kg/dose every 6-8 hours but best at night to help child sleep Hydroxyzine (Atarax®) • 2 mg/kg/day divided every 6-8 hours Sarna Lotion® (camphor and menthol) Eucerin® Itch-Relief Moisturizing Spray Atopic Dermatitis Moisturize the SKIN: Bathe frequently as directed Soak in tepid water for 20 minutes (add 1 cup salt to water, if needed for stinging Apply topical corticosteroids while the skin is still damp Cover with petroleum jelly (Vaseline®) or Aquaphor® Atopic Dermatitis Use topical corticosteroids Ointments = good penetration; Occlusion is good, except in hot weather Great in dry or plaque-like areas Creams and lotions = less penetration “More convenient” Good in hot weather Intertriginous areas Hairy areas Atopic Dermatitis Avoid irritants to the SKIN: Wear soft cotton clothing Avoid wool, harsh materials Avoid cigarette smoke Avoid feather pillows, fuzzy toys, stuffed animals Don’t use carpeting in bedrooms Minimize exposure to dogs and cats Reduce perspiration Avoid foods that worsen the rash • Treat secondary infection (usually staphylococci) Nummular Eczema Much Thicker Lesions Potent topical steroids in an ointment base Frequent lubrication Avoid irritants (wool, harsh or drying soap) Treat secondary infection (staphylococci) Corticosteroids Use the least potent for the shortest time IV. Medium Potency Fluocinolone (Synalar®) Ointment 0.025% Hydrocortisone Valerate (Westcort®) Ointment 0.2% V. Lower-Mid Potency Triamcinolone (Kenalog ®) Ointment 0.1% Fluticasone (Cutivate®) Cream/Lotion 0.05% Hydrocortisone Valerate (Westcort®) Cream 0.2% VI. Mild Potency Aclometasone (Aclovate®) Ointment 0.05% VII. Low Potency Hydrocortisone 2.5% Ointment, Cream Hydrocortisone 1% Ointment, Cream (OTC) When You Write Muliple Rx’s Fluocinolone Ointment 0.025% SMALL TUBE Use on BAD eczema 2 times a day until better. TEACH BACK: Where are you going to put this one… Triamcinolone Ointment 0.1% BIG TUBE Use on MEDIUM eczema 2 times a day until better. Remind family NOT to look at the percentages on the medications! Hydrocortisone Ointment 2.5% 454 gms (One Pound Jar) Use on MILD eczema and dry skin 2 times a day. Seborrheic Dermatitis: Dry patches of thick, yellowbrown and greasy crusts Mile topical steroids reduce: Inflammation Scaling Number of lesions Seborrheic Dermatitis: Cradle Cap Best Treatment: May be the lack of treatment Frequent shampoo: Baby shampoo if mild Head and Shoulders™ if moderate Scales: may be removed manually Loosen first with warm mineral oil Seborrheic Dermatitis: May present in adolescents as dandruff Shampoos for the scales: Salicylic acid (Neutrogena® T/Sal) Salicylic + tar (Neutrogena® T/Gel) Zinc pyrithione (Head and Shoulders® or DHS™ Zinc Shampoo) Selenium (Selsun Blue®) For pruritis Steroid solution can help, but sting (Lidex® or Synalar®) Seborrheic Dermatitis: In diaper area Salmon-colored, scaly lesions Greasy Intertriginous and flexural areas are heavily involved Candidiasis: Seborrheic Dermatitis: May get secondary infections Topical antibacterial agent: Bactoban® • Apply BID with good hand washing If widespread, add oral antibiotic: Augmentin® • 90 mg/kg/day divided BID Keflex® • 25-100 mg/kg/day divided TID Culture if not responding or MRSA? If candida, add anticandidal agent: Nystatin® or Lotrimin® • Apply until clear PLUS 3-7 more days Refer to a Pediatric Dermatologist Contact Dermatitis Shoe Dermatitis: Rubber adhesives; Tanning “Sweaty Sock Dermatitis”: Hyperhidrosis Fiberglass Dermatitis: Fiberglass particles Video Display Terminal Dermatitis Lip Licker’s Dermatitis: Saliva “Dr. Jane’s Medicine” Low Potency Topical Corticosteroid Nickel Dermatitis Contact Dermatitis Avoid offending metal: • • • • • • Earrings and jewelry Belt buckles Buttons on blue jeans Zippers Clothing fasteners, snaps Guitar strings Coat the offending metal • Clear nail polish • Moleskin • Topical aerosol dexamethasone (Decaspray®) to both surfaces Potent topical steroids Rhus Dermatitis Poison Ivy: Delayed Contact Hypersensitivity Oleoresin (Urushiol) Resin: Wash off ASAP after exposure Clothes and shoes must be removed Clothing: Wash in soap and water or cold water and alcohol Treatment: Topical antipruritic: Calamine® Potent topical corticosteriods Systemic antihistamine/antipruritic Systemic corticosteroids when needed Hypersensitivity Reaction to an Insect/Mosquito Bite • Super high potency steroid will drastically reduce swelling, redness, and itching. • Class 1 Steroid • Clobetasol 0.05% Ointment Sig: Apply ONLY 1 -2 times. • If it doesn’t work RIGHT AWAY, it likely won’t. • Consider 2° Infection Head Lice: Don’t Freak Out! Head Lice: Don’t Freak Out! Make sure there are LIVE LICE! Lice die if off humans for 24-55 hours Eggs die if not at temp near scalp Many treatments kill lice but not eggs Lice can hold their breath for hours! Most pediculocides need to be repeated Day 9 may be optimal Three treatments: 0, 7 and 13-15 days Rinse pediculocides: Over a sink to avoid skin contact In warm, not hot, water to absorption Head Lice Treatments 1% Permethrin Cream Rinse: Nix® OTC Pyrethrins: RID® OTC 5% Permethrin Cream: Elimite® Rx Malathion Lotion (Ovide®) Home remedies: Petroleum jelly; mayonnaise; margarine Olive oil Herbal oils Kerosene A Bit Nit Picky? “Treat and return” policy AAP Clinical Report 2011 Head Lice Treatments • • • • • • • • • • Nit comb Lice MD ® Lice Shield® LiceFreee® and Vamouse® Ivermectin (Sklice®) Rx Benzyl Alcohol (Ulesfia®) Rx Spinosad (Natroba®) LouseBusterTM Ivermectin (Stromectol®) Nit Picking Service Physical removal Dimethicone Oils Natrum Muriaticum Parayzes lice + eggs Asphyxiation of lice Insecticide Hot air desiccation Anthelmintic PILL! National Association of Lice Treatment Professionals An untreated head louse standing on a hair (from Speare et al,33 with permission) A Nuvo-treated head louse coated with dried-on DSP lotion Copyright ©2004 American Academy of Pediatrics www.nuvoforheadlice.com Cleaning Personal Items Scabies Scabies • 5% Permethrin: Elimite® Treat everyone in the house Repeat in 1 week Emphasize: Do NOT use more than 2 applications, which must be one week apart Itching will continue for 3+weeks • Antipruritics: AM: Loratadine, Cetrizine HS: Benadryl® or Atarax® Low potency steroid: hydrocortisone 1 or 2.5% • Antibiotics: if infected Bed Bug Bites Bed Bug What To Do About Bed Bugs: Getting rid of them is not easy! Good advice: • Don’t bring them home! • Look for them when travelling and on your luggage. • Don’t put anything on the floor of a hotel room. • Don’t pick up mattresses or furniture from the curb! • Run clothes through a dryer on high heat. • There are poisons, but they are poisons. • There are professional exterminators, but they may not solve the problem in one, expensive trip. What To Do About Bed Bug Bites: • Give treatment for itchiness so bites don’t get infected. Antihistamines orally. Topical steroids of low to mild potency. • Give antibiotics if bites are infected. • Give the family pictures of bed bugs. • 91% Isopropyl Alcohol: Spray liberally, spray often! Strawberry Tongue Raspberry Tongue Strep Throat: Scarlet Fever Rash Group A Beta Hemolytic Strep Antibiotics are required: Penicillin Erythromycin Alternatives to consider: Amoxicillin: • 40-60mg/kg/day divided BID Azithromycin (Zithromax®): • 12mg/kg/day for 5 days Perianal Strep: Antibiotics: Patient may need 20 days of amoxicillin or a stronger antibiotic for perianal strep. Impetigo Small areas: topically Bactoban® • Apply BID with good hand washing Large areas: orally Augmentin® ES • 90 mg/kg/day divided BID Keflex® • 50 mg/kg/day divided TID Clindaycin if MRSA suspected Can the lesions be covered? Let’s Review SA: Staphylococcus Aureus MSSA: Methicillin Sensitive Staph Aureus MRSA: Methicillin Resistant Staph Aureus MRSA-HA: MRSA-Hospital Acquired MRSA-MDR: MRSA-Multiple Drug Resistant MRSA-CA: MRSA-Community Acquired MRSA-CS: MRSA-Clindamycin Sensitive MRSA-CA: MRSA-Clindamycin Resistant MSSA-CA: MSSA PVL+ Recommendations: MSSA: Keflex or Augmentin MRSA: Clindamycin MRSA MDR: TMP/SMX Add Rifampin (never use alone) Topical Mupirocin Linezolid in severe infections Vancomycin, if inpatient In Your Handouts Additional Information about: • Staphylococcus • MRSA • Common Causes of Contact Dermatitis • Acne And that is a very good place to End! Staphylococcus Aureus: “Staph for Short” • Gram positive bacteria. • Humans are colonized: • Skin. • Nose. • Throat. • GI tract. Staphylococcus Aureus: Before Antibiotics • Caused severe infections, disfiguring scars, disabling chronic infections, and death. • Mortality rates ~30%. • Therapy was surgical drainage, cauterization or amputation. Chusid, MJ, Grand Rounds: MRSA, 2007 1928: Fleming Discovers Penicillin • The first antibiotic is discovered. • Produced by molds of the genus Penicillium. • Difficult to isolate bacteria-killing component. • 1941: First use in a human. • Extensive use saved lives of WWII soldiers. Penicillin: Resistance • We made penicillin. • Staph produced β-lactamase. • Resistance occurred within one year of using penicillin. Methicillin: Semi-synthetic Penicillin • We made semi-synthetic penicillins that were more effective against β-lactamase. • We made Methicillin (1961). • Resistance to methicillin in 1961. Resistance to Multiple Drugs • We start treated Staph with more drugs. • Staph developed multiple drug resistance (MDR). • These are called MRSA-MDR. Staphylococcus Aureus: Why are they such a bugger? • Have surface proteins that allow for attachment and damage. • Produce enzymes that cause local damage. • Secrete toxins. • Survive by developing resistance. Chusid, MJ, Grand Rounds: MRSA, 2007 MRSA MDR: Acquired in Hospitals: MRSA-HA • Staph with resistance to multiple drugs were first acquired in hospitals. • Associated with risk factors such as ICUs, post-op, dialysis, immune-compromised state, and prolonged antibiotic use. • Limited cases in community, except with recent exposure to health care setting. Chusid, MJ, Grand Rounds: MRSA, 2007 MRSA: Acquired in Communities: MRSA-CA • Staph with different susceptibilities start to appear in large numbers in the community from: Schools; Daycares; Sports teams; Recreational centers; Emergency Departments. • These MRSA-CA organisms are more pathogenic than hospital acquired despite being sensitive to more antibiotics. Chusid, MJ, Grand Rounds: MRSA, 2007 Compare At-Risk Populations MRSA HA • • Patients in a hospital. Patients in health care settings or long-term care. Patients with invasive medical devices. MRSA CA • • • • Infants in diapers. Athletes. Prisoners. Military recruits. Chusid, MJ, Grand Rounds: MRSA, 2007 Compare Risks Factors MRSA HA ICU. Post-operative. Dialysis. Tracheostomy. Immune-compromised. Prolonged antibiotic use. MRSA CA Prior MRSA infection. Multiple infected family members. Young age (Birth-5 yrs). Abnormal skin: eczema, trauma. History of “spider bite”. Chusid, MJ, Grand Rounds: MRSA, 2007 Compare Genetic Coding SCC = Staph Cassette Chromosome, the DNA carrier. mec = is the genetic locus for PBP2a production. MRSA HA SCCmec I, II, III. MRSA CA SCCmec IV, not seen before. The genetic structure coding for The mecIV codes only for MRSA MRSA and MDR. not other drugs. Large chromosomes that don’t transmit easily to other Staph. SCCmec IV is small and transmits easily to other MSSA. Chusid, MJ, Grand Rounds: MRSA, 2007 Losing Clindamycin Susceptibility While on Therapy or at Relapse • Clindamycin is still the drug of choice for MRSA-CA infections because of the high rate of clindamycin susceptibility. • HOWEVER: there is a small but significant failure rate after initial therapy. • Organisms originally Clindamycin S/Erythromycin R are developing clindamycin resistance. • Some MRSA-CA have a second resistance factor which induces clindamycin resistance during therapy! Chusid, MJ, Grand Rounds: MRSA, 2007 MRSA-CA/MRSA-CS The “D” or Double Diffusion Test Erythromycin resistant MRSA strain lawn placed on plate Erythromycin and clindamycin disks are placed adjacently. Cut off (‘D’ shape) of clinda zone demonstrates organism will develop resistance on Rx. At CHW, organism will be reported resistant on initial report only after D testing. Chusid, MJ, Grand Rounds: MRSA, 2007 New Toxicity Factors? Panton Valentine Leukocidin (PVL) • A more potent toxin, creating more invasive diseases. • Now showing up in both MRSA & MSSA. • In some cases: • The PVL came in with MRSA-CS genes → • The MRSA gene was lost → • Leaving aggressive MSSA PVL+ . • The PVL is transforming the “wimpy” strains that are PCN sensitive into very aggressive strains. Chusid, MJ, Grand Rounds: MRSA, 2007 GERMS: WE vs. THEM • • • • • • We need them. They need us. We have barriers to keep them “out”. They cause problems when they get “in”. We try to kill them. They become more resistant. Patient Education: Critical Component of Management 1. 2. 3. 4. 5. 6. 7. Wash hands regularly. Keep draining wounds covered. Maintain good general hygiene. Do not share potentially contaminated items. Wash clothing exposed to wound drainage. Do not participate in activities involving skin contact until the wound is healed. Clean equipment and other environmental surfaces. Adapted from Gorwitz R, et al. Strategies for Clinical Management of MRSA in the Community: Summary of an Experts’ Meeting Convened by the Centers for Disease Control and Prevention. March,2006. The Importance of Follow-Up in Out-Patient Management • • • • Drain the pus! Schedule a follow-up visit in 24-48°. Return if symptoms do not improve. Return for worsening local symptoms • Return promptly if systemic symptoms. MRSA Key Points: • Hand-washing is still best defense. • Find out what you are treating. • Use antibiotics wisely. • Resistance comes from exposure. • Follow-up! Contact Dermatitis PRIMARY IRRITANT: • • • • Harsh Soaps, Bubble baths, Bleach Detergent, Solvents, Talcum Powder Foods Saliva, Urine, Feces, Intestinal Secretions ALLERGIC CONTACT: • • • • Nickel, Vinyl, Lanolin(Wool), Adhesive Tape Medications (Neosporin) Perfumes, Hair Dyes, Lipstick, Antiperspirants Poison ivy, Plants, Pollen (Ragweed) Acne BLACKHEADS WHITEHEADS Papules and pustules Acne Pilosebaceous unit: Abnormal keratinization Follicular canal obstruction Androgenic stimulation Sebum formation Propionibacterium acnes hydrolyzes sebum into irritating free fatty acids Intradermal explosion with inflammation in the skin 1 3 2 4 1. 2. 3. 4. Open comedo: “blackhead” Closed comedo: “whitehead” Papule or pustule:”zits” Nodule: “undergrounder” Acne: Don’t PICK Prevent follicular hyperkeratosis Reduce P. acnes Reduce free fatty acids Eliminate comedos papules pustules nodules cysts Acne: Don’t PICK Topical therapy: Dove Fragrance Free 2% Salicylic acid • Neutrogena® Oil-Free Acne Wash Benzoyl Peroxide 2.5 to 10% • Bar, wash, lotion, cream, gel • Lots of OTC preparations Vitamin A Acid • Retin-A® 0.025% Adapalene (retinoid receptor) • Differin® 0.1% cream, gel Acne Antibiotics: Only for inflammatory lesions Topical • Clindamycin Cleocin®; Clindagel®; Clindets® • Erythromycin T-Stat® Systemic • Tetracycline 500 mg BID • Minocycline 50-100mg BID Minocin Pellets® Acne: Don’t PICK Vitamin A Acid and Benzoyl Peroxide The results are more dramatic when they are used in combination: There is less irritation than Vitamin A alone Systemic antibiotics can often be reduced Use one in the morning, one at night Differin® is less irritating than Retin-A® Use Vitamin A Acid on DRY skin so need to wait 30 minutes after washing face to apply A little dab will do it! Acne Management Teach patient about acne Stress NO PICKING, gentle washing Try benzoyl peroxide in the morning Add Retin-A or Differin at night Use antibiotics for inflammatory lesions and wean as tolerated Adjust treatment as needed for patient satisfaction Unresponsive Acne Vulgaris: Cysts and nodules Scarring Isotretinoin: Accutane Refer to a dermatologist