Katalog kurser på forskarnivå HT15
Transcription
Katalog kurser på forskarnivå HT15
Katalog kurser på forskarnivå HT15 # Människans biologi eller sjukdomslära * Allmänvetenskapliga kurser 1202 Human Cell Culture. Methods and Applications 20150921 20150925 (Engelska) 1383 Basic Course in Medical Statistics * 20151130 20151211 (Engelska) 1386 Philosophy of science and research ethics * 20151102 20151106 (Engelska) 1386 Philosophy of science and research ethics * 20150907 20150911 (Engelska) 1386 Philosophy of science and research ethics * 20151130 20151204 (Engelska) 1386 Medicinsk vetenskapsteori och forskningsetik * 20151005 20151009 (Svenska) 1391 Writing science and information literacy * 20151123 20151204 (Engelska) 1392 Vetenskapligt skrivande och informationskompetens * 20151026 20151106 (Svenska) 1472 Infections in the Tropics 20151014 20151231 (Engelska) 1496 Flow cytometry: from theory to application 20150921 20150925 (Engelska) 1507 Rörelseapparaten klinisk utvärdering av funktion och behandling 20151012 20151016 (Svenska) 1559 Experimental techniques in study of metabolic and endocrine disorders 20151130 20151204 (Engelska) 1577 Epidemiology I: Introduction to epidemiology 20150902 20150911 (Engelska) 1579 Biostatistics I: Introduction for epidemiologists * 20150916 20151006 (Engelska) 1594 Tumor immunology and immune therapy of cancer 20151116 20151120 (Engelska) 1595 Molecular Immunology 20151012 20151023 (Engelska) 1622 Epidemiology II. Design of epidemiological studies 20150831 20150909 (Engelska) 1626 Cytokines in inflammation 20151116 20151127 (Engelska) 1627 Clinical and experimental neuroimmunology 20151012 20151016 (Engelska) 1635 Basic course in Tumor Biology and Oncology 20150831 20150911 (Engelska) 1794 Study design in clinical research 20151116 20151204 (Engelska) 1814 Methods for Qualitative Content Analysis 20150929 20151125 (Engelska) 1873 Quality of life as an outcome measure in care sciences 20151116 20151127 (Engelska) 1974 Phenotyping of genetically engineered mice 20151207 20151211 (Engelska) 1999 Embryology I 20151012 20151016 (Engelska) 2000 Advanced seminars in Tumor Biology 20150901 20151222 (Engelska) 2001 What is life? The future of biology. 20150916 20160217 (Engelska) 2044 Pathology # 20151019 20151030 (Engelska) 2074 Current Topics in Infection Biology 20150902 20151216 (Engelska) 2132 Forskningsetik * 20150825 20150915 (Svenska) 2133 Vetenskapsteori * 20151006 20151201 (Svenska) 2135 Infectious Disease Epidemiology 20151012 20151016 (Engelska) 2144 To communicate science in different contexts * 20150916 20151001 (Engelska) 2154 Cardiovascular Epidemiology 20151019 20151023 (Engelska) 2166 Basic Tumor Histopathology 20150914 20150925 (Engelska) 2176 Cellular and molecular infection biology 20151026 20151106 (Engelska) 2186 How to make genetically modified mice for immunological research 20150907 20150911 (Engelska) 2188 Developmental biology for regenerative medicine 20150831 20150911 (Engelska) 2283 Live cell imaging 20151005 20151016 (Engelska) 2291 Clinical achievements of reproductive medicine 20150921 20150925 (Engelska) 2302 Basic immunology 20150915 20151029 (Engelska) 2348 Functional Fluorescence Microscopy Imaging (fFMI) in biomedical research 20151102 20151113 (Engelska) 2381 Survey of Molecular Endocrinology 20150928 20151009 (Engelska) 2407 Aktuell Omvårdnadsvetenskap teori och praxis 20151002 20151120 (Svenska) 2416 Causal Inference for Epidemiological Research 20151130 20151204 (Engelska) 2418 Methods in molecular biology and their applications in medical research 20150907 20150918 (Engelska) 2430 Principles of nucleic acid structure 20151116 20151204 (Engelska) 2433 Clinical Research in Lipid Metabolism 20151019 20151023 (Engelska) 2454 Public health intervention and implementation research 20151019 20151120 (Engelska) 2484 Thrombosis and Hemostasis, from mechanisms to therapies 20151102 20151106 (Engelska) 2498 Obesity basic science, clinical and epidemiological aspects 20151116 20151120 (Engelska) 2515 Cancer cell energy metabolism 20151102 20151106 (Engelska) 2518 Basics of Qualitative research 20150914 20150918 (Engelska) 2525 Cellular Reprogramming from basal mechanisms to medical applications 20150914 20150918 (Engelska) 2526 Neuropschopharmacology 20151123 20151201 (Engelska) 2536 The major global infectious diseases: tuberculosis and HIV 20151123 20151127 (Engelska) 2561 Writing Science and Information Literacy * 20150824 20151016 (Engelska) 2570 Introduction to R statistical analysis for biologists 20151109 20151113 (Engelska) 2583 Noncoding RNA and cancer 20151130 20151204 (Engelska) 2600 Neurogenetics 20150928 20151002 (Engelska) 2605 Brain development and Neurodevelopmental disorders 20150921 20150925 (Engelska) 2608 Mechanisms of Gene Regulation in Metabolism 20151105 20151111 (Engelska) 2609 Basic Course in Medical Statistics a distance course * 20150921 20151002 (Engelska) 2616 Frontiers in Cogntive Neuroscience 20150914 20150918 (Engelska) 2618 Write your research results and get them published * 20151012 20151023 (Engelska) 2618 Write your research results and get them published * 20150928 20151009 (Engelska) 2618 Write your research results and get them published * 20151116 20151127 (Engelska) 2618 Write your research results and get them published * 20150907 20150918 (Engelska) 2618 Write your research results and get them published * 20151130 20151211 (Engelska) 2624 Brain circuits 20150907 20150911 (Engelska) 2629 Neurodegenerative disorders I From molecule to treatment 20151005 20151009 (Engelska) 2630 Neurodegenerative disorders II cellular and molecular mechanisms 20151012 20151016 (Engelska) 2644 Human physiology an overview # 20150914 20150925 (Engelska) 2644 Människans fysiologi en översikt # 20150907 20150918 (Svenska) 2647 Surgical Techniques in Rat and Mouse 20150921 20150925 (Engelska) 2652 Mesenchymal stem cells biology and clinical potential. 20151012 20151016 (Engelska) 2654 Grounded Theory in Health Research 20151130 20151211 (Engelska) 2657 Introduktionskurs i R datahantering, analys och grafisk presentation 20151105 20151127 (Svenska) 2666 Metoder för statistisk analys: Från variansanalys till multilevel modeling * 20151012 20151030 (Svenska) 2668 Evidensbaserad verksamhet inom hörsel, öron, språk och tal 20150901 20151218 (Svenska) 2671 Tumor microenvironment 20151123 20151127 (Engelska) 2686 Introduction to teaching at KI * 20150902 20151007 (Engelska) 2688 Multidisciplinary perspectives on active ageing research 20150921 20151217 (Engelska) 2690 Basic Laboratory Safety * 20151109 20151116 (Engelska) 2690 Basic Laboratory Safety * 20150928 20151005 (Engelska) 2693 Measuring physical activity with focus on wearable monitors applications for clinical and epidemiological studies 20151023 20151123 (Engelska) 2704 Metoder för systematisk litteraturöversikt 20150907 20151215 (Svenska) 2717 Hematopoiesis and hematopoietic stem cells in health and disease 20151026 20151030 (Engelska) 2721 Culture and Brain 20150901 20160215 (Engelska) 2743 Writing skills for science * 20150813 20150816 (Engelska) 2780 The Developing Brain 20150831 20150904 (Engelska) 2787 Present your research! * 20150831 20151110 (Engelska) 2787 Present your research! * 20150825 20151109 (Engelska) 2790 How to conduct systematic reviews and metaanalyses 20151019 20151104 (Engelska) 2794 Medical developmental biology 20150817 20150821 (Engelska) 2796 Introduction to Stata for epidemiologists 20150914 20150915 (Engelska) 2797 Biostatistics II: Logistic regression for epidemiologists * 20151207 20151216 (Engelska) 2827 Människans Fysiologi en översikt # 20151216 20160115 (Svenska) 2833 Introduction to Quantile Regression and Related Methods 20151102 20151106 (Engelska) 2839 Philosophy of science and research ethics, statistics and oral scientific communication * 20150921 20151023 (Engelska) 2841 The third dimension of nuclear functions 20151012 20151016 (Engelska) 2843 The cell cycle 20151116 20151120 (Engelska) 2844 Exploring entrepreneurial opportunities in research * 20151116 20151120 (Engelska) 2845 Cellbased heart regeneration 20150928 20151002 (Engelska) 2846 Integration of Neuroimaging and Cognition in Normal Aging and Dementia 20151109 20151113 (Engelska) 2849 Cancer and cancer stem cells 20151116 20151120 (Engelska) 2852 Initiating entrepreneurial thinking in connection to research 20150914 20151218 (Engelska) 2854 Translational lung cancer research 20151021 20151022 (Engelska) 2855 Digital photomicrography 20151019 20151023 (Engelska) 2856 Teaching and Learning in Higher Education: educational course for doctoral students a distance course * 20150911 20151217 (Engelska) 2857 Orientation in qualitative research methods 20151105 20151119 (Engelska) 2858 Longitudinal data analysis classical and modern statistical methods 20151102 20151113 (Engelska) 2859 DNA damage and maintenance of genome integrity 20151012 20151016 (Engelska) 2860 Extracellular vesicles: a tool for diagnostics and therapy. 20151109 20151113 (Engelska) 2861 Biomedical Ecology The microbiota in health and disease 20151123 20151127 (Engelska) 2865 Regulatory RNAs in Development, Disease and Evolution 20151007 20151016 (Engelska) Title : Human Cell Culture. Methods and Applications Kursnummer : 1202 Antal högskolepoäng : 1.5 Datum : 20150921 20150925 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Kursens lärandemål : After the course, the students should be well acquianted with the theory and practice of cell culture. Knowledge in basic and stateoftheart methods applied to cell cultures. To have developed skills for bench work with cell cultures on an individual basis. Kursens innehåll : Cell culture reflecting stem, transit amplifying, differentiated and terminally differentiated tissue states; Monolayer and organotypic culture involving one or more cell types. Applicability of cell cultures as alternatives to laboratory animal experiments. Mechanisms regulating cell growth and viability, differentiation and apoptosis. Assessment of cell transformation to immortal and malignant phenotypes. Isolation of specific cells, e.g., epithelial cells,characterisation of cultured cells. Handling and sterile techniques, choice of materials and media for cell culture, e.g., serumdependent vs. serumfree culture conditions. Cell cloning and gene transfer. Practical handling of cultures: thawing/freezing, passage, expansion and longterm storage. Handling of normal and tumor tissue for optimizing obtainment of cultures. Tissue engineering practices. Transcriptomics, proteomics and informatics methods for biomedical research with cell lines. Discussion of participants own culture experience and problems. Arbetsformer : Lectures, laboratory work, ITuse and group discussions on pitfalls and possibilities with cell cultures. Examination : Literature studies and oral presentation of results for the course participants. Obligatoriska moment : Presence at scheduled lectures and time allocated for oral examination of allparticipants is compulatory. Opportunity to follow missed lectures is possible at repeat courses twice a year (graduate courses 1202 and 1862). Based on documented participation in the lectures, the oral examination can be arranged separately with the course organizer. Antal studenter : 10 15 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Roland Grafstrom Institutet för miljömedicin [email protected] Kontaktpersoner : Johanna Bergman Institutet för miljömedicin [email protected] Nobels väg 13 17177 Stockholm Roland Grafstrom Institutet för miljömedicin [email protected] Title : Basic Course in Medical Statistics Kursnummer : 1383 Antal högskolepoäng : 3.0 Datum : 20151130 20151211 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : The course participants shall after the course be able to perform and interpret basic descriptive statistics from frequency tables and graphical presentations, perform and interpret results from basic statistical analysis and test (like ttest, chisquare test, nonparametric test and Regression analysis), as well as have enhanced their ability to recognize, understand and critically view the statistics being presented in articles within the medical field of research. Kursens innehåll : The course is an introduction to basic statistical principles and how statistics play a part in medical research. Concepts being treated are hypothesis, type I error, type II error, estimates, measurement of dispersion, regression analysis, inference making and how to present the results. Arbetsformer : This course is a so called TeamBased Learning (TBL)course. TBL is a special form of learning that integrates individual assessment and group work with immediate feedback. Focus will be on solving statistical problems in a group/team setting. This two weeks course consists of online preparation through video lectures and exercises, and several TBL sessions (in class meeting). The in class meetings will correspond to twothree full days each course week. The time in between meetings will be spent reading the course material, and preparing for the assessment and group application exercises. Examination : Individual and group assessments and active participation during the group application exercises. Obligatoriska moment : In class attendance during TBL sessions are mandatory for passing grade. If the student misses more than one TBL occasion, the doctoral student must take the course again. Antal studenter : 40 50 Urval av studenter : Date for registration as a doctoral student (priority given to earlier registration date). Please make sure that you have entered the correct registration date for doctoral education in your personal profile. Övrig information : This course is a TBLcourse. TBL, TeamBased Learning, is a special form of learning that integrates individual work, group work and immediate feedback. Focus will be on solving statistical problems in group/team setting. The course has the same content and length as the original course 1383. The course will consist of 2 3 full days per week for two weeks. Kursansvarig : Mesfin Tessma Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Margareta KrookBrandt Institutionen för lärande, informatik, management och etik 52487118 Margareta.Krook[email protected] Title : Philosophy of science and research ethics Kursnummer : 1386 Antal högskolepoäng : 1.5 Datum : 20151102 20151106 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : No Kursens lärandemål : The objective of this course is for the doctoral student to gain a basic understanding of the philosophy of science and insight into and understanding of key ethical theories, principles and guidelines related to research and thereby be given the opportunity to reflect on the ethical aspects of his/her own research. The objective is also to provide the doctoral student with an understanding of what is good research practice, and also an understanding of the boundary between what is ethically acceptable or unacceptable in terms of experimentation with human beings and animals. After completing the course, the research student should: be able to give an account of the positions relative to the philosophy of science and research ethical theories, principles and, to some extent current guidelines know the most important terms within the philosophy of science and demonstrate knowledge of common problem situations in research ethics and of the ethical tools used to manage conflicts concerning research ethics be able to analyse ethical conflicts in research and see the connection between the philosophy of science and research ethics be able to construct sustainable research ethical arguments for or against a specific course of action have developed an ethical approach to research Kursens innehåll : The course includes the following: Key ethical principles and theories of research Fundamental values for empirical research, and standards of good scientific practice Experiments on humans, including a review of informed consent, its ethical basis, and the pros and cons of practices for informed consent Ethical tests and guidelines on how to conduct ethical research, such as the Helsinki Declaration Ethics and the use of laboratory animals, including arguments for and against using animals for research purposes, as well as the three Rs Handling of authorship in scientific writing Conflicts of interest in research Key scientific terms and positions Arbetsformer : Introducing lectures, group work and general discussions. Examination : The doctoral students write a short informal essay on a scientific or research ethical theme related to their own research. Obligatoriska moment : Attendance is mandatory for the group work and general discussions. If the student is absent, he or she can compenste by handling in written answers concerning the cases that have been discussed. Antal studenter : 30 35 Urval av studenter : Selection is based on 1) the date of PhD registration (where prior registration dates have priority) 2) curriculum relevant to the candidate's PhD project (as motivation). Övrig information : Kursansvarig : Gert Helgesson Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Emma Karlsson Institutionen för lärande, informatik, management och etik 08524 83 777 [email protected] Title : Philosophy of science and research ethics Kursnummer : 1386 Antal högskolepoäng : 1.5 Datum : 20150907 20150911 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : No Kursens lärandemål : The objective of this course is for the doctoral student to gain a basic understanding of the philosophy of science and insight into and understanding of key ethical theories, principles and guidelines related to research and thereby be given the opportunity to reflect on the ethical aspects of his/her own research. The objective is also to provide the doctoral student with an understanding of what is good research practice, and also an understanding of the boundary between what is ethically acceptable or unacceptable in terms of experimentation with human beings and animals. After completing the course, the research student should: be able to give an account of the positions relative to the philosophy of science and research ethical theories, principles and, to some extent current guidelines know the most important terms within the philosophy of science and demonstrate knowledge of common problem situations in research ethics and of the ethical tools used to manage conflicts concerning research ethics be able to analyse ethical conflicts in research and see the connection between the philosophy of science and research ethics be able to construct sustainable research ethical arguments for or against a specific course of action have developed an ethical approach to research Kursens innehåll : The course includes the following: Key ethical principles and theories of research Fundamental values for empirical research, and standards of good scientific practice Experiments on humans, including a review of informed consent, its ethical basis, and the pros and cons of practices for informed consent Ethical tests and guidelines on how to conduct ethical research, such as the Helsinki Declaration Ethics and the use of laboratory animals, including arguments for and against using animals for research purposes, as well as the three Rs Handling of authorship in scientific writing Conflicts of interest in research Key scientific terms and positions Arbetsformer : Introducing lectures, group work and general discussions. Examination : The doctoral students write a short informal essay on a scientific or research ethical theme related to their own research. Obligatoriska moment : Attendance is mandatory for the group work and general discussions. If the student is absent, he or she can compenste by handling in written answers concerning the cases that have been discussed. Antal studenter : 30 35 Urval av studenter : Selection is based on 1) the date of PhD registration (where prior registration dates have priority) 2) curriculum relevant to the candidate's PhD project (as motivation). Övrig information : Kursansvarig : Gert Helgesson Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Emma Karlsson Institutionen för lärande, informatik, management och etik 08524 83 777 [email protected] Title : Philosophy of science and research ethics Kursnummer : 1386 Antal högskolepoäng : 1.5 Datum : 20151130 20151204 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : No Kursens lärandemål : The objective of this course is for the doctoral student to gain a basic understanding of the philosophy of science and insight into and understanding of key ethical theories, principles and guidelines related to research and thereby be given the opportunity to reflect on the ethical aspects of his/her own research. The objective is also to provide the doctoral student with an understanding of what is good research practice, and also an understanding of the boundary between what is ethically acceptable or unacceptable in terms of experimentation with human beings and animals. After completing the course, the research student should: be able to give an account of the positions relative to the philosophy of science and research ethical theories, principles and, to some extent current guidelines know the most important terms within the philosophy of science and demonstrate knowledge of common problem situations in research ethics and of the ethical tools used to manage conflicts concerning research ethics be able to analyse ethical conflicts in research and see the connection between the philosophy of science and research ethics be able to construct sustainable research ethical arguments for or against a specific course of action have developed an ethical approach to research Kursens innehåll : The course includes the following: Key ethical principles and theories of research Fundamental values for empirical research, and standards of good scientific practice Experiments on humans, including a review of informed consent, its ethical basis, and the pros and cons of practices for informed consent Ethical tests and guidelines on how to conduct ethical research, such as the Helsinki Declaration Ethics and the use of laboratory animals, including arguments for and against using animals for research purposes, as well as the three Rs Handling of authorship in scientific writing Conflicts of interest in research Key scientific terms and positions Arbetsformer : Introducing lectures, group work and general discussions. Examination : The doctoral students write a short informal essay on a scientific or research ethical theme related to their own research. Obligatoriska moment : Attendance is mandatory for the group work and general discussions. If the student is absent, he or she can compenste by handling in written answers concerning the cases that have been discussed. Antal studenter : 30 35 Urval av studenter : Selection is based on 1) date of PhD registration (where prior registration dates have priority) 2) the curriculum relevant to the candidate's PhD project (as motivation). Övrig information : Kursansvarig : Gert Helgesson Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Emma Karlsson Institutionen för lärande, informatik, management och etik 08524 83 777 [email protected] Title : Medicinsk vetenskapsteori och forskningsetik Kursnummer : 1386 Antal högskolepoäng : 1.5 Datum : 20151005 20151009 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Nej Kursens lärandemål : Målet med kursen är att den forskarstuderande ska få en grundläggande vetenskapsteorisk förståelse och inblick i och förståelse av centrala forskningsetiska teorier, principer och riktlinjer och därmed få möjlighet att reflektera över etiska aspekter av den egna forskningen. Målet är också att den forskarstuderande ska få en förståelse av vad som är god forskningssed, samt var gränsen går för vad som är etiskt oacceptabelt både vad gäller försök med människor och med djur. Den forskarstuderande ska efter att ha gått kursen: kunna redogöra för vetenskapsteoretiska positioner samt forskningsetiska teorier, principer och, i viss mån, riktlinjer känna till centrala vetenskapsteoretiska termer samt vanliga forskningsetiska problemsituationer och de etiska verktygen för att hantera forskningsetiska konflikter kunna analysera forskningsetiska konflikter och se kopplingen mellan vetenskapsteori och forskningsetik kunna ge hållbara forskningsetiska argument för eller mot ett förfarande ha utvecklat ett forskningsetiskt förhållningssätt Kursens innehåll : Kursen innehåller följande moment: Centrala forskningsetiska principer och teorier Grundläggande värderingar för empirisk forskning samt normer för god vetenskaplig sed Försök med människor, inklusive en genomgång av informerat samtycke, dess etiska grund och för och nackdelar med rutiner för informerat samtycke Etikprövningar och forskningsetiska riktlinjer, såsom Helsingforsdeklarationen Försöksdjursetik, innefattande argument för och emot att använda djur för forskningsändamål, samt de tre R:en Hantering av vetenskapligt författarskap Intressekonflikter i forskningen Centrala vetenskapliga termer och positioner Arbetsformer : Introducerande föreläsningar, grupparbeten och plenumdiskussioner. Examination : Deltagarna skriver en egen vetenskapsteoretisk eller forskningsetisk reflektion över sitt eget forskningsprojekt. Obligatoriska moment : Vid frånvaro krävs särskilt utförliga svar på de fall som diskuterats. Gruppdiskussionerna och plenumdiskussionerna är obligatoriska. Antal studenter : 30 35 Urval av studenter : Urvalet baseras på 1) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) 2) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering). Övrig information : Kursansvarig : Gert Helgesson Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Emma Karlsson Institutionen för lärande, informatik, management och etik 08524 83 777 [email protected] Title : Writing science and information literacy Kursnummer : 1391 Antal högskolepoäng : 3.0 Datum : 20151123 20151204 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Karolinska Institutet University Library Särskild behörighet : Kursens lärandemål : After the course, you should be able to demonstrate: understanding of how to write an original scientific article and submit it for publication the ability to write other types of texts required for a scientific career the ability to give, take and make use of constructive criticism the ability to search and manage the medical sciences literature in a structured way the ability to use resources which facilitate choosing a journal to publish your research in the ability to describe aspects of postpublication evaluation and processing of the medical sciences literature Kursens innehåll : Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structure and style, Ethical issues in writing, Publication process, Principles of medical information retrieval, Databases, Reference management, Choosing a journal and Evaluating published science Arbetsformer : Individual writing and rewriting, lectures, working in pairs and groups, webbased teaching, demonstrations, computer exercises and individual study. NOTE THAT THIS IS THE KISOLNA CAMPUS VERSION OF THE COURSE. THERE IS ALSO AN ONLINE VERSION (COURSE CODE 2561) INTENDED PRIMARILY FOR DOCTORAL STUDENTS HAVING DIFFICULTIES TO ATTEND THE KISOLNA CAMPUS COURSES. Examination : Writing a grant application (including references) with popular science summary and rewriting based on peer and teacher feedback. There are also three assignments in which participants demonstrate development of their information literacy. Obligatoriska moment : The course writing assignment is obligatory and has to be submitted about 10 days BEFORE course start. All scheduled teaching is compulsory (except where clearly stated otherwise). Absence can usually be compensated for by reading and individual work after consultation with course leaders. Antal studenter : 30 34 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : David Herron Karolinska Institutet Universitetsbibliotek 08524 841 13 [email protected] Berzelius 7B 17177 Stockholm Kontaktpersoner : Title : Vetenskapligt skrivande och informationskompetens Kursnummer : 1392 Antal högskolepoäng : 3.0 Datum : 20151026 20151106 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Karolinska Institutet University Library Särskild behörighet : Kursens lärandemål : Efter kursen ska du kunna visa: förståelse för hur man skriver en vetenskaplig artikel och skickar in den för publicering förmåga att skriva andra typer av texter som en del i det vetenskapliga arbetet förmåga att ge, ta emot och använda konstruktiv kritik förmåga att söka och hantera den vetenskapliga litteraturen på ett strukturerat sätt förmåga att använda olika resurser som stöd vid valet av tidskrift att publicera sig i förmåga att beskriva aspekter av hur man kan utvärdera publicerad vetenskap Kursens innehåll : Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structure and style, Ethical issues in writing, Publication process, Principer för medicinsk databassökning, Databaser, Referenshantering, Val av tidskrift och Evaluera publicerat vetenskap. Arbetsformer : Individuella skrivuppgifter och revision, föreläsningar, par och grupparbeten, webbaserat lärande, demonstrationer, datorövningar och individuella studier. OBS. KURSDELEN SOM BEHANDLAR VETENSKAPLIGT SKRIVANDE HÅLLS PÅ ENGELSKA OBS. DET FINNS OCKSÅ EN ONLINE VERSION AV KURSEN PÅ ENGELSKA (KURSKOD 2561) AVSEDD PRIMÄRT FÖR DOKTORANDER MED SVÅRIGHETER ATT VARA MED PÅ KI CAMPUS SOLNA KURSERNA. Examination : Skrivande av en anslagsansökan (på engelska) med populärvetenskaplig sammanfattning (på svenska) samt bearbetning (med referenser) baserat på "peer" och lärarkommentarer. Det finns också tre uppgifter som demonstrerar utvecklingen av deltagarnas informationskompetens. Obligatoriska moment : Skrivuppgiften är obligatorisk och måste inlämnas cirka 10 dagar FÖRE kursens början. Samtliga schemalagt undervisningpass är obligatoriska. Frånvaro kan oftast kompenseras efter samtal med kursledarna. Antal studenter : 30 34 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : Kursansvarig : David Herron Karolinska Institutet Universitetsbibliotek 08524 841 13 [email protected] Berzelius 7B 17177 Stockholm Kontaktpersoner : Title : Infections in the Tropics Kursnummer : 1472 Antal högskolepoäng : 7.5 Datum : 20151014 20151231 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : Kursens lärandemål : To understand the conditions under which the major infectious diseases in the tropics arise and how they are prevented/treated locally. To understand the conditions for biomedical research in a low or middle income country from within and to be able to account for some of the current local research issues. To be able to discuss these issues with health care professionals and researchers in a satisfactory way. Kursens innehåll : Field studies under local staff in low or middle income country and Swedish supervision at the primary,secondary and tertiary health care level. Joint seminars (mutual presentations of research projects) at local research institute. Students will present their findings of elective projects at the end of the course. Arbetsformer : Bedside and benchside teachings at hospitals and polyclinics/health care centers. Seminars. Elective works with oral and written presentations. Field studies will take place in in a low or middle income country. Examination : Formative assessment of ability to discuss the specific issues encountered with health care professionals and researchers. Presentation of elective projects to Swedish faculty. Every student will be examined individually. Obligatoriska moment : Field studies, joint seminars at local research institute, presentation of elective projects. Absence cannot be compensated for. Antal studenter : 5 10 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course starts with five twohour evening lectures covering the major tropical infections such as malaria, helminth infections, tuberculosis/leprosy and leishmania trypanosomiasis. These will take place Wednesday evenings between 17.3019.00 hrs, starting Oct 14, 2015 at the Dept of Infectious Diseases, Karolinska Hospital,Solna. One additional session will be devoted to designing elective projects to be conducted during the field session in Ethiopia.<br /> <br /> Field session in Ethiopia is planned for between Nov 28 Dec 21, 2015.<br /> <br /> Final course week will be between Dec 28 Dec 31, 2015 when elective projects will be reported/discussed and a written quiz issued. <br /> <br /> A fee of US$1500 will be required to contribute towards full board accommodation and local transport costs. An official receipt of the paid sum will be issued for putative reimbursement by the home Department. International travel and tuition/bench fees will be covered by the course grant. Kursansvarig : Sven Britton Institutionen för medicin, Solna 0851771967 [email protected] Oxtogsgränd 1 11157 Stockholm Kontaktpersoner : Anne Rasikari Institutionen för medicin, Solna 08517 718 61 [email protected] B3:03 Sven Britton Institutionen för medicin, Solna 0851771967 [email protected] Oxtogsgränd 1 11157 Stockholm Title : Flow cytometry: from theory to application Kursnummer : 1496 Antal högskolepoäng : 1.5 Datum : 20150921 20150925 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : Kursens lärandemål : Through this oneweek course, the participants will acquire the knowledge of flow cytometry principles. They will know flow cytometric sample preparation and analysis, protocol setup, as well as data interpretation. Kursens innehåll : The course covers basic knowledge and main applications of flow cytometry, and contains both lectures and laboratory/group work. Experts in different fields of flow cytometric application are invited to give the lectures. The participants will be able to learn: a) Principles of flow cytometry: working mechanisms of flow cytometer; molecular and cellular probes for flow cytometry; quality control; and safty procedures and intrument maintainance. b) Basic skills: flow cytometric protocol design; sample handling and storage; data processing and analysis, and data presentation. c) Major applications of flow cytometry in biomedical research: leukocyte phenotyping, endothelial cell analysis, stem cell analysis, apotosis, platelet measurement, cell function analysis (including membrane potential, oxidative metabolism, intracellular calcium mobilization, pH, and intracellular organelles), as well as nucleic acid analysis. Arbetsformer : The course includes 28 hr lectures and 12 hr handson lab work. Examination : The exam will consist two parts: a 30min written test on flow cytometric principles; and a 60 min handson lab work examining flow cytometric lab skills Obligatoriska moment : The participants must attend handson lab sections during two afternoons. The students who have missed these sections can book extra lab section time within 4 weeks to compensate the absence. Antal studenter : 20 32 Urval av studenter : The course used to receive far more applications than the maximal course slots of 32. Selection of the participants is thus needed and made according to: 1) How relevant is flow cytometry to the thesis project? 2) How urgent is the flow cytometry training for her/his project work? 3) Has the student applied for the course before? Övrig information : The course will be held during week 39 (Sept 2125, 2015; 9:0016:30). Lecture hall booked: Block Salen, T4:00 at Karolinska University HospitalSolna. Lectures will be given by 1415 lecturers, usaually half of them from institutions outside KI, with one or two from abroad. All the lecturers are wellestablished flow cytometrists on their lecture subjects. The course has been given 12 times/year at KI for 14 years. It has been highly appreciated by the participants through the years, with a median general satisfaction score never below 8 (out of 9; referred to paperbased course evaluation between 20012013), and highly remarked with the websurvey (2014). Kursansvarig : Nailin Li Institutionen för medicin, Solna 0851773996 [email protected] Clinical Pharmacology Unit Karolinska University HospitalSolna 17176 Stockholm Kontaktpersoner : Nailin Li Institutionen för medicin, Solna 0851773996 [email protected] Clinical Pharmacology Unit Karolinska University HospitalSolna 17176 Stockholm Title : Rörelseapparaten klinisk utvärdering av funktion och behandling Kursnummer : 1507 Antal högskolepoäng : 1.5 Datum : 20151012 20151016 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Molecular Medicine and Surgery Särskild behörighet : Kursens lärandemål : Kunskaper: Kunskaper om metoder, försöksplanering och statistisk bearbetning av material inom kliniska forskningsprojekt som berör rörelseorganens sjukdomar och skador. Färdighet: Kunna framställa och värdera en forskningsplan för ett projekt inom rörelseorganens sjukdomar. Förhållningssätt: Ha lärt sig ett vetenskapligt och kritiskt förhållningssätt till den vetenskapliga litteraturen inom området för rörelseorganens sjukdomar och skador. Kursens innehåll : Klinisk utvärdering av funktion och behandling inom rörelseorganens sjukdomar och skador. Arbetsformer : Katedrala föreläsningar, gruppövningar kring ett tänkt forskningsprojekt. Examination : Kursdeltagarna redovisar de forskningsprojekt som de arbetat med under kursen och projektet diskuteras med övriga kursdeltagare och en lärarpanel bestående av kursledningen och speciellt inbjudna experter. Under denna diskussion testas kursdeltagarnas kunskaper, färdigheter, värderingsförmågor och förhållningssätt utifrån lärandemålen Obligatoriska moment : Antal studenter : 5 20 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : Kunskaper: Kunskaper om metoder, försöksplanering och statistisk bearbetning av material inom kliniska forskningsprojekt som berör rörelseorganens sjukdomar och skador. Färdighet: Kunna framställa och värdera en forskningsplan för ett projekt inom rörelseorganens sjukdomar. Förhållningssätt: Ha lärt sig ett vetenskapligt och kritiskt förhållningssätt till den vetenskapliga litteraturen inom området för rörelseorganens sjukdomar och skador. Klinisk utvärdering av funktion och behandling inom rörelseorganens sjukdomar och skador. Katedrala föreläsningar, gruppövningar kring ett tänkt forskningsprojekt. Kursdeltagarna redovisar de forskningsprojekt som de arbetat med under kursen och projektet diskuteras med övriga kursdeltagare och en lärarpanel bestående av kursledningen och speciellt inbjudna experter. Under denna diskussion testas kursdeltagarnas kunskaper, färdigheter, värderingsförmågor och förhållningssätt utifrån lärandemålen Kursansvarig : Lars Weidenhielm Institutionen för molekylär medicin och kirurgi [email protected] Kontaktpersoner : Title : Experimental techniques in study of metabolic and endocrine disorders Kursnummer : 1559 Antal högskolepoäng : 1.5 Datum : 20151130 20151204 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Molecular Medicine and Surgery Särskild behörighet : Kursens lärandemål : After the course the students will be able i) to measure glucose transport in isolated rodent skeletal muscle; ii) to measure lipolysis in isolated adipocytes; iii) to dissect out mouse pancreatic islets and measure the insulin release; iv) to judge and analyze obtained data. The students will be able to describe the possibilities and limitations of the above techniques. Kursens innehåll : The aim of this course is to provide methodology to solve preclinical problems in metabolic and endocrine research. The course is laboratory based, aiming to give all participants hands on experience with isolation of pancreatic islets, skeletal muscle and adipose tissue. Theoretical and practical considerations will be presented and discussed. Arbetsformer : The course meets for five days full time, including three full day laboratory practical sessions. The first day will consist of several lectures to give a background to the metabolic questions which will be addressed in the practical part of the course. Our aim is to provide the student with a hands on experience of each technique covered. In order to achieve this, for the laboratory work the course participants will be subdivided into smaller groups. Examination : The laboratory notebook examination from each student, a short oral presentation of the project work and a short summary of the project work by each group. Obligatoriska moment : All three laboratory tasks are compulsory; as an exception, a written task could be given to a participant to compensate absence. Antal studenter : 9 18 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Alexander Chibalin Institutionen för molekylär medicin och kirurgi 0852487512 [email protected] Kontaktpersoner : Title : Epidemiology I: Introduction to epidemiology Kursnummer : 1577 Antal högskolepoäng : 1.5 Datum : 20150902 20150911 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medical Epidemiology and Biostatistics Särskild behörighet : Kursens lärandemål : After successfully completing this course students are expected to be able to: give examples of the contribution of epidemiology to science and discuss the importance of epidemiology as a research discipline. estimate and in a general way interpret measures of disease occurrence and measures of association, and describe how a specific measure is governed by the study design. explain strengths and weaknesses of common epidemiological study designs. identify and explain possible sources of bias in epidemiological studies. describe theoretical models for causation and discuss the principles of causal mechanisms. apply knowledge of epidemiological concepts when critically reviewing scientific literature. Learning outcomes are classified according to Bloom´s taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Kursens innehåll : The course gives an introduction to epidemiological theory and practice. It comprises basic principles regarding design, interpretation, and analysis of epidemiological studies. It introduces the concept of causation, concepts related to measures of disease occurrence and measures of association, common designs for epidemiological studies (with main focus on cohort studies), and the role of bias. Arbetsformer : The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts. Different strategies for teaching and learning will be used, such as lectures, group discussions and various forms of group exercises on selected topics. Examination : To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methods used are group assignments along with written and oral individual tasks. The examination is viewed as contributing to the development of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered a second chance to resubmit the examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. Obligatoriska moment : The examination tasks are compulsory. Antal studenter : 12 25 Urval av studenter : Selection will be based on 1) the relevance of the course for the applicant's project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). Submit a completed application form and give all information requested, including a short description of current research, motivation for attending and an account of previous courses. Övrig information : Course dates are: September 2, 4, 7, 9 and 11. The course is extended over 2 weeks (but still 5 full course days) in order to promote reflection and reinforce learning Kursansvarig : Fang Fang Institutionen för medicinsk epidemiologi och biostatistik [email protected] Kontaktpersoner : Gunilla Nilsson Roos Institutionen för medicinsk epidemiologi och biostatistik 08524 822 93 [email protected] Title : Biostatistics I: Introduction for epidemiologists Kursnummer : 1579 Antal högskolepoäng : 3.0 Datum : 20150916 20151006 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medical Epidemiology and Biostatistics Särskild behörighet : Kursens lärandemål : After successfully completing this course students should be able to: define the concept of probability, laws of probability, and make simple probability calculations. (S2) suggest a statistical distribution to describe a naturally occurring phenomonen and evaluate the appropriateness of the distribution given real data. (S3) present appropriate descriptive statistics for an epidemiological study. (S2) explain the difference between hypothesis testing and interval estimation and the relation between pvalues and confidence intervals. (S3) suggest an appropriate statistical test for a comparison of two groups, perform the hypothesis test using standard statistical software, and interpret the results. (S3) estimate and interpret three alternative measures of association between binary exposures and binary outcomes and discuss the relative merits of each measure for a given research question. (S3) explain the concept of confounding in epidemiological studies and demonstrate how to control/adjust for confounding using stratified analysis. (S2) explain the basis of the linear regression model, fit a linear regression model using standard statistical software, assess the fit of the model, and interpret the results. (S2) Learning outcomes are classified according to Bigg's structure of the observed learning outcome (SOLO) taxonomy: (S1) unistructural, (S2) multistructural, (S3) relational, and (S4) extended abstract. Kursens innehåll : The course introduces classical statistical concepts and methods with emphasis on methods used in epidemiology and public health. Topics covered include: the importance of statistical thinking; types of data (nominal, binary, discrete and continuous variables); data summary measures; contingency tables; graphical representations; notions of probability; probability models (distributions); principles of statistical inference; parameter estimation (mean, proportion (prevalence), incidence and ratios); concepts of confidence intervals and hypothesis tests; and a general introduction to correlation and linear regression models. Arbetsformer : Lectures, exercises focusing on analysis of real data using statistical software, exercises not requiring statistical software, group discussions, literature review. Examination : The course grade is based mainly on a written examination, but group tasks and individual written assignments are also used. The course is divided into two parts, and each part will be examined separately. To pass the course, a student must pass both parts. Students who fail will be offered a re examination within 2 months of the final day of the course. Students who fail the reexam will be given top priority for admission the next time the course is offered. If the course is not offered during the following two academic terms then another reexamination will be scheduled within 12 months of the final day of the course. Obligatoriska moment : Antal studenter : 12 25 Urval av studenter : Selection will be based on 1) the relevance of the course for the applicant's project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). Submit a completed application form and give all information requested, including a short description of current research, motivation for attending and an account of previous courses. Övrig information : The course is extended over time in order to promote reflection and reinforce learning. The course will be held the dates: September 16, 17, 18, 21, 22 and examination September 24 (week 1), and September 28, 29, 30 and October 1, 2 and examination October 6 (week 2). We strongly recommend prior knowledge in Stata software. Kursansvarig : Yudi Pawitan Institutionen för medicinsk epidemiologi och biostatistik [email protected] Kontaktpersoner : Gunilla Nilsson Roos Institutionen för medicinsk epidemiologi och biostatistik 08524 822 93 [email protected] Title : Tumor immunology and immune therapy of cancer Kursnummer : 1594 Antal högskolepoäng : 1.5 Datum : 20151116 20151120 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of OncologyPathology Särskild behörighet : Kursens lärandemål : After the course is completed the students will be able to (1) explain important aspects of tumor immunology, (2) indicate advantages and disadvantages of different immune therapy strategies, (3) explain mechanisms of immune escape, 4) hypothesize how different immunebased regimens may affect clinical outcome in patients with cancer. Kursens innehåll : This course covers basic and applied immunology and a current review of experimental research and clinical application of tumor immunology. Both preclinical and clinical aspects of cancer vaccination, adoptive cell therapy, and antibody therapy will be discussed. Development of novel therapies through modification of immune cell subsets will be presented. Features of the tumor microenvironment, cancerassociated inflammation, immune surveillance and escape, and immunosuppression will also be discussed. Planning, performing, and monitoring of clinical trials are included in the course as well. One to two days are dedicated to lectures by invited international experts from the field. Arbetsformer : Lectures, seminars, group discussions and casestudies. Examination : Oral group presentation and individual assignment based on casestudies. Every student will be individually assessed. Obligatoriska moment : Antal studenter : 12 32 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Full day lectures/assignments from Monday to Friday at the Lecture hall of the Cancer Center Karolinska (R8:00). There will at least 4 invited international speakers. Kursansvarig : Rolf Kiessling Institutionen för onkologipatologi 0851776857 [email protected] Kontaktpersoner : Andreas Lundqvist Institutionen för onkologipatologi [email protected] Jeroen Melief Institutionen för onkologipatologi [email protected] Kristina Witt Institutionen för onkologipatologi [email protected] Title : Molecular Immunology Kursnummer : 1595 Antal högskolepoäng : 3.0 Datum : 20151012 20151023 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Kursens lärandemål : After the course, the student should be able to relate their own research project to the cuttingedge developments in other areas of immunology research. Furthermore, they should have gained increased experience in preparing and presenting novel information about an immunological problem or a specific technique to their fellow students. Kursens innehåll : The course is given during 2 weeks. Invited national and international lecturers give their views on selected problems, or techniques, in immunology. The seminars take off from basic facts, but the speakers are encouraged to move on to current problems, and to focus on both scientific and methodological aspects. To merit 3 full ECTS points for the course, students will be asked, in a group project work, to study an immunological method or problem deeply at the theoretical level and lecture about this method to the fellow students. At the end of the course, a written and an oral presentation is expected from all students. Arbetsformer : Lectures, group work, oral and written presentations Examination : Evaluation of oral and written presentation of project work. Specific contibution of each group participant will be investigated and evaluated. A short written exam based on the content of the course. Obligatoriska moment : Oral presentations at the end of the course. Written project work and written test. If a student misses the presentation, a special presentation with the course leader will be arranged. Antal studenter : 10 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course will be held on weekdays with most lectures from 9.00 to 12.00. All lectures will be held at MTC Nobelsväg 16 on the Solna Campus. The course will also include invited lecturers from universities outside Sweden who are experts in their field Kursansvarig : Jonathan Coquet Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Kontaktpersoner : Robert Wallin Institutionen för medicin, Huddinge 0858589197 [email protected] Benedict Chambers Institutionen för medicin, Huddinge [email protected] Title : Epidemiology II. Design of epidemiological studies Kursnummer : 1622 Antal högskolepoäng : 1.5 Datum : 20150831 20150909 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Knowledge in epidemiology equivalent to "Epidemiology I: Introduction to epidemiology" or corresponding courses. Kursens lärandemål : After successfully completing this course you as a student are expected to be able to: in a selfdirected manner, formulate the principles of different types of common epidemiological study designs. mainly independently, explain how a specific measure of disease occurrence and measure of association is governed by the study design. in a selfdirected manner, explain and discuss epidemiological concepts, including accuracy, in the context of different epidemiological study designs. draw conclusions from epidemiological scientific papers and to review and criticize these regarding study design, results and accuracy. Learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Kursens innehåll : The course focus on issues related to study design (primarily casecontrol methodology), study base, study efficiency, matching in epidemiological studies, induction time, interpretation of epidemiologic evidence. Arbetsformer : Lectures, group discussions and various forms of group exercises on selected topics, will be used. The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts. Examination : To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methods used are group tasks along with written and oral individual tasks.The examination is viewed as a contributing to the development of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. Obligatoriska moment : Only the examination tasks are compulsory. Antal studenter : 12 25 Urval av studenter : Prerequisite knowledge Epidemiology I: Introduction to epidemiology or corresponding. We also strongly recommend Biostatistics I: Introduction for epidemiologists or equivalent. Selection will be based on 1) the relevance of the course for their research 2) the stated motivation for attending the course. Please submit a completed application form and give all information requested incl. a short description of current research, motivation for attending and an account of previous courses taken. Övrig information : The course is extended over time in order to promote reflection and reinforce learning. Course dates are: August 31, September 2, 4, 7 and 9. Kursansvarig : Karin Leander Institutet för miljömedicin 0852487498 [email protected] Box 210 (Nobels väg 13), KI 171 77 Stockholm Kontaktpersoner : Ida Kettley Cronfalk Institutet för miljömedicin [email protected] Title : Cytokines in inflammation Kursnummer : 1626 Antal högskolepoäng : 3.0 Datum : 20151116 20151127 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : None Kursens lärandemål : Objectives At the end of the course the participant should be able to: select adequate experimental methods to analyze cytokines based on specific scientific questions understand the relevance of cytokines in the context of their research project compare and contrast the function of cytokines in different organs and different diseases explain how a disease can be treated with drugs targeting cytokines hypothesize future treatment of a disease, where the modification of a cytokine pattern is the target Kursens innehåll : Learning how to measure cytokine responses in different ways and understanding the function of cytokines in immunological networks. Arbetsformer : The course is partly theoretical, partly practical, where lectures and laboratory demonstrations are integrated. Time is also allocated for discussing of lab results and lectures, and for group assignment. Examination : To pass the course the participant has to: actively participate in the discussions during the course present a seminar where different aspects of a cytokine will be discussed, i.e. disease involved and overall biological effects, and describe and discuss methods to detect it within the methods presented during the course. take a written exam during the last day of the course. This exam will cover the course's theoretical and practical content. Obligatoriska moment : Practical sessions are compulsory, unless stated not. Absence from several practical sessions cannot be compensated for, but absence from one theoretical session can be compensated for in subsequent sessions. Antal studenter : 15 25 Urval av studenter : Priority will be given to 1) PhD students working in the field of immunology 2) early stage students with at least basic knowledge in immunology (year 1 2), and 3) expressed written motivation to attend the course. Övrig information : The aim of the course is to provide an increased understanding of the function of cytokines in the context of healthy immune system and in different disease contexts. Note: This is not a basic course of immunology. Location: KI campus Solna. Time: 09.0016.00 all days. Course content includes lectures from invited experts and KI experts, and local staff are also involved in practical work. Kursansvarig : Andre Ortlieb Institutionen för klinisk neurovetenskap [email protected] Kontaktpersoner : Heidi Wähämaa Institutionen för medicin, Solna [email protected] Title : Clinical and experimental neuroimmunology Kursnummer : 1627 Antal högskolepoäng : 1.5 Datum : 20151012 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Clinical Neuroscience Särskild behörighet : Kursens lärandemål : After this course the students should be able to: (i) describe the basic clinical characteristics of the major neuroinflammatory diseases; (ii) design experiments using animal models for neuroinflammatory diseases in rats and mice, compare models and discuss their advantages and limitations, (iii) evaluate and interpret new findings and recent scientific papers in the field and (iv) speculate on molecular mechanisms underlying neuroinflammatory disease and hypothesize how knowledge on these mechanisms can enable therapy and prevention. Kursens innehåll : The course includes the overview of clinical symptoms, signs, pathology, treatments and diagnostic criteria for the most important neuroimmunological conditions including Multiple Sclerosis, Myasthenia Gravis, GuillainBarré Syndrome, Alzheimer¿s disease as well as infections, trauma, tumors and pain. Also included is an overview of experimental models of neuroimmunological diseases, with an emphasis on techniques for genetic analysis (intercrosses, congenics, transgenics etc). Key molecular concepts in neuroinflammation are covered such as immune mechanisms of disease as well as tissue degeneration/regeneration. Different techniques used to study neuroinflammation are discussed such as imaging and flow cytometry. Arbetsformer : The course combines: (i) traditional lectures given by experts in the field, consisting of a mixture of both clinicians as well as basic researchers covering diseases, technological aspects or basic processes in neuroimmunology; (ii) an individual assignment followed by an interactive presentation/discussion on the last day. The assignment will consist of a presentation of a highimpact scientific paper relevant to the student¿s own research topic and that is of importance for the neuroimmunology field. Examination : Examination will be based on the presentation of the own individual assignment and the subsequent discussion during the last day of the course (please see "Teaching and learning activities") and the feedback given to other students on their assignments. In their presentation, students should be able to comment on their article of choice in the context of the items described above under "learning outcomes". Guidelines for the preparation of the assignment will be sent out to the students two weeks before the start of the course. Obligatoriska moment : All lectures and individual presentations are compulsory. Compensation for absence can be discussed with the course directors. Antal studenter : 10 25 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : This course is part of both the Neuroscience and the Allergy, Immunology and Inflammation Doctoral Programmes Time: MondayFriday, 9:0017:00; Location: Center for Molecular Medicine (CMM), Karolinska University Hospital, Solna, building L8, lecture hall/seminar room; Speakers last year included Prof Jan Hillert (MS genetics), Docent Adnane Achour (MHCTCR interaction), Prof Tomas Olsson (MS), Dr Rayomand Press (GBS), Prof Fredrik Piehl (neuroprotection), Prof. Dr. Frauke Zipp (University of Mainz; CNSimmune cell interaction); Prof. Burkhardt Becher (University of Zurich; Tumors in the CNS) Kursansvarig : Xingmei Zhang Institutionen för klinisk neurovetenskap [email protected] CMM Stockholm Kontaktpersoner : Andre Ortlieb Institutionen för klinisk neurovetenskap [email protected] Pernilla Strid Institutionen för klinisk neurovetenskap [email protected] Maja Jagodic Institutionen för klinisk neurovetenskap +46851776258 [email protected] Neuroimmunology Unit, CMM, L8:04 17176 Stockholm Title : Basic course in Tumor Biology and Oncology Kursnummer : 1635 Antal högskolepoäng : 3.0 Datum : 20150831 20150911 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of OncologyPathology Särskild behörighet : Kursens lärandemål : This is a basic course for all PhDstudents in the field. After the course the students will have an understanding of the cancer problem, the modern view what cancer is, from a clinical and basic science view. You will get the basic foundations of cancer biology as well as aquire some ability to discuss and understand advanced problems in cancer biology. You will have an idea which are the current most important problems to solve in cancer, to improve diagnosis, prevention, treatment and quality of life. The over all aim of the course is to form a bridge between preclinical and clinical aspects of tumor biology and oncology for PhD students and to provide the students an understanding of all aspects of the cancer problem. This course is a basic introduction to modern cancer research and is recommended to all PhD students within basic and clinical cancer research. Kursens innehåll : The course will describe the causes as well as the consequences of the transformation of a normal cell into its malignant counterpart, in order to create an understanding of cancer from molecule to patient, eventually also discussing the management and treatment of malignant diseasesThe topics of the course include genetics, the cell cycle, apoptosis, immunology, diagnostics and treatment, all topics presented from the cancer perspective. There will be focus on a few malignant diseases, described in more detail serving as models for basic concepts of Tumor Biology and Oncology, including molecular genetics, curative treatment and palliative care, psychosocial aspects of cancer, ethics and epidemiology. All seminars and demonstrations are compulsory, also some lectures, as well as the written examination. Single missed occasions can be compensated during the course after discussion with te course director. Arbetsformer : The course consists of lectures, group seminars, group discussions and demonstrations. Full time during two consecutive weeks. Examination : Written examination with a focus on understanding of concepts, relations and how and how problems are dealt with in cancer research. Obligatoriska moment : This course is full time for two weeks. All seminars and demonstrations are compulsory, also some lectures, as well as the written examination. Single missed occasions can be compensated during the course after discussion with te course director. Antal studenter : 20 35 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is scheduled full time for 2 weeks. Nonclinicians will be offered to join Meetapatient sessions. Kursansvarig : Svetlana Bajalica Lagercrantz Institutionen för onkologipatologi 0851771797 [email protected] Trastvägen 24 18279 Stocksund Kontaktpersoner : Daria Glaessgen Institutionen för onkologipatologi [email protected] Title : Study design in clinical research Kursnummer : 1794 Antal högskolepoäng : 4.0 Datum : 20151116 20151204 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Molecular Medicine and Surgery Särskild behörighet : Kursens lärandemål : After completion of the course the students should be able to: 1) Independently plan and produce a study protocol including a thorough methodological evaluation and choice of appropriate study design. 2) Critically reflect on other students individual project work in a scientifically constructive way. 3) Interpret and critically evaluate scientific studies relevant to the course content. Kursens innehåll : The course is designed for PhDstudents, in particular those who are at an early stage of their research education, and those with an interest in conducting clinical research. The content of the course is as follows: 1) Basic terms in epidemiology and clinical study design, 2) Measures of disease occurrence and incidence, causality, 3) Observational studies cohort and casecontrol studies, 4) Systematic and random errors, 5) Experimental studies, randomised clinical trials, 6) Quality of life in clinical research, 7) Examination and course evaluation. Throughout the course, the students will work on an individual project (examination 1) for peerreview (examination 2). Further, students will critically review and discuss relevant scientific articles (examination 3). Arbetsformer : Lectures, seminars, individual article review, group discussions and homework tasks will be used. The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts. Therefore, much of the focus of the course is on the individual project where students are required to develop a full study protocol including several important aspects covered in the lectures, article reviews and group discussions. Students will also peerreview eachothers projects and this will form the basis for the final examination seminar. Examination : To pass the course the student must actively participate in the course and pass the examinations: 1) Individual project work: To develop a written comprehensive yet concise study protocol including several important aspects study design as discussed during the course; 2) Peerreview of other students projects followed by oral presentation own project and opposition of other students projects during the group examination; 3) Critically review scientific articles relevant to the course content and participate actively in the seminars. Obligatoriska moment : Compulsory attendance includes the scheduled lectures and seminars. Absence will need to be replaced by individual assignments following discussion with the course coordinator, e.g. article reviews, with written or oral followup. Antal studenter : 18 25 Urval av studenter : Selection will be based on 1) Date of registration as a PhD student 2) suitability of PhD project 3) The motivation to attend the course. Övrig information : Kursansvarig : Nele Brusselaers Institutionen för molekylär medicin och kirurgi 0851770942 [email protected] UGIR Norra Stationsgatan 67 17176 Stockholm Kontaktpersoner : Kalle Mälberg Institutionen för molekylär medicin och kirurgi [email protected] Title : Methods for Qualitative Content Analysis Kursnummer : 1814 Antal högskolepoäng : 4.5 Datum : 20150929 20151125 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Kursens lärandemål : After completing the course the student will be able to: * critically comment on literature describing the development and method of content analysis. * choose an adequate design for his/her own data. * describe the different elements of the analysis. * carry out the analysis. * critically evaluate the weaknesses and strengths of the method of analysis. Kursens innehåll : Development from a quantitative to a qualitative tradition of content analysis Design and choice of analysis Different elements of the analysis Application and critically evaluation Arbetsformer : The course includes lectures, seminars and individual assignments. The students will in project work during the whole course with support from lectures, individual literature assignments apply content analysis in their own research and reflect on that application in a critical way. Examination : The students will finally in their project work demonstrate their knowledge and understanding of content analysis by submitting a paper containing the use of the analysis with regard to the learning outcomes. Obligatoriska moment : The course in its whole needs active involvement of the students through participation in the various types of teaching. Antal studenter : 15 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The dates for the course are: September 2930, October 2021 and November 2425, Alfred Nobels allé 23, KI campus Huddinge. Course leaders: Kenneth Asplund and Ella Danielson Kursansvarig : Lena Koch Institutionen för neurobiologi, vårdvetenskap och samhälle 52483555 [email protected] Kontaktpersoner : Miriam Entesarian Matsson Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Title : Quality of life as an outcome measure in care sciences Kursnummer : 1873 Antal högskolepoäng : 3.0 Datum : 20151116 20151127 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Kursens lärandemål : After the course, the students should be able to critically review research papers describing quality of life results and to design a study with quality of life as an outcome measure. This includes phrasing research questions, choosing appropriate instruments, timing of assessments and procedure as well as choosing methods for analysis. Furthermore should students be able to interpret and discuss results from studies of quality of life. Kursens innehåll : The concept quality of life and healthrelated quality of life will be discussed to give insights into these concepts. Aditionally the criticism against these concepts and their measurement will be addressed.The course will further include phrasing research questions, choosing appropirate instruments, designing studies measuring quality of life (timing of assessments and procedure), choice of methods for analysis, and interpretation of results. Arbetsformer : The course is divided in two parts, the first part consist of three fulltime days and the second part of two fulltime days, three weeks later. The course is based on lectures during morning sessions, which will be followed up in groupseminars in the afternoons. Between the two parts of the course students are required to hand in one homework task which will constitute the examination. Examination : The examination consists of a review of a research proposal. The task will be introduced during the first part of the course. Obligatoriska moment : Groupseminars are compulsory and absence from them will be made up with a essaywriting on the topics that were to be discussed in the groupseminar. Antal studenter : 15 25 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Course dates: November 1617, 2627. The course will take place at Alfred Nobels Allé 23 in Huddinge. <br>A mix of learning activities will be used such as lectures, seminars, work in groups and individual assignments. The topics that will be covered include the concept quality of life, design and sample selection, data collection relating to psychometric properties of the instruments the students are using in their own research, analysis and reporting of results. Students will in groups scrutinize each other's research proposals which will be presented the last day of the course as part of the course examination assignment. Students are also asked to hand in a written individual assignment within one week of the last course day. Kursansvarig : Lena Wettergren Institutionen för neurobiologi, vårdvetenskap och samhälle 0852483650 [email protected] Kontaktpersoner : Title : Phenotyping of genetically engineered mice Kursnummer : 1974 Antal högskolepoäng : 2.0 Datum : 20151207 20151211 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Comparative medicine Särskild behörighet : Kursens lärandemål : Mål för kunskap och förståelse Efter kursen skall studenterna kunna redogöra för fenotypning av genetiskt modifierade möss, beskriva systematisk och standardiserad fenotypsanalys av både transgena och knock in/outmöss. Studenten skall kunna redovisa för olika strategier för framställning av genetiskmodifierade möss, avelsproblematik, samt för tekniker och medel för undersökning av både enklare parametrar och mer specialiserade funktioner såsom beteende, kardiovaskulär fysiologi, neurobiologi och utvecklingsbiologi samt för djurskyddsaspekter. Mål för praktiska färdigheter Efter kursen skall studenten kunna identifiera målorgan för fenotypanalys Efter kursen skall studenten kunna genomföra praktiska undersökningar av genetiskt modifierade möss (obduktionsteknik). Efter kursen skall studenten kunna identifiera och särskilja mellan olika dataanalyser. Kursens innehåll : Denna kurs syftar till att visa hur genetiskt modifierade möss kan fenotypas på ett strategiskt sätt; genom urval av relevanta "endpoints" och med användande av så få djur som möjligt, genom planering av olika testar som ska genomföras. Den ger baskunskaper i systematisk fenotypsanalys av både transgena och knockin/out möss. Kursen belyser relevanta delar av musens biologi och fysiologi, strategier för framställning av genetiskmodifierade möss, avelsproblematik, samt redogör för tekniker och medel för undersökning av både enklare parametrar och mer specialiserade funktioner såsom beteende, kardiovaskulär fysiologi, neurobiologi och utvecklingsbiologi. Kursen omfattar laborationer (obduktionsteknik), demonstrationer av olika moment. Arbetsformer : Kursen omfattar föreläsningar, laborationer, demonstrationer och grupparbete med seminarieuppgifter. Kursen går heltid och dagtid. Kursspråket är engelska. Examination : Lärandemål för kunskap och förståelse examineras genom redovisning av grupparbete. Obligatoriska moment : Grupparbeten och avslutande seminarier är obligatoriska. Bortvaro under kursen kompenseras enligt instruktioner från kursansvarig. Antal studenter : 10 20 Urval av studenter : The applicants will be first selected for the relevance of the course to their research projects. Then will the date for registration as a PhD student have priority. Övrig information : The course will take place at Comparative Medicine Learning Lab in Solna. It is a one week course with full time studies. International lecturers in the subject like Cory Baryton, Associate Professor in Molecular and Comparative Pathobiology from John Hopkins University and Björn Rozell, Professor in Laboratory Animal Pathology at University of Copenhagen will be present among others. Kursansvarig : Raoul Kuiper Institutionen för laboratoriemedicin [email protected] Kontaktpersoner : Dude Gigliotti Komparativ medicin 0852486529 [email protected] von Eulers väg 4a, plan 4 171 77 STOCKHOLM Title : Embryology I Kursnummer : 1999 Antal högskolepoäng : 1.5 Datum : 20151012 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Biosciences and Nutrition Särskild behörighet : Kursens lärandemål : At the conclusion of this course students should be have a good understanding of: Why in vitro systems are suboptimal in producing viable human embryos relative to development in vivo Main components of the culture system (culture media, tissue culture plastics, gases, incubators, workstations, laboratory environment, input materials) Physicalchemical properties of culture system (osmolarity and pH of culture media, temperature, light levels) and how they can be influenced Constitution of tubal and uterine fluids and the evolution of culture media used in ART programmes as well as nutritional requirements of the various cell stages from gamete to blastocyst Tissue culture vessels Functional characteristics of different tissue culture incubators Functional characteristics of different workstations for ART and their benefits The influence of the laboratory and clinic environment on embryo culture The influence of the quality of the input material on outcomes in ART The morphology of oocytes, zygotes and cleavage stage embryos as well as morulae and blastocysts Developmental milestones Predictors of developmental potential Biochemical tests for predicting developmental potential The use of ultrasound to assess oocyte quality Student should be aware of the general aspects and implication of the stem cells research and the potentiality that this represent for clinical application Morphological aspects of the blastocysts for derivation of ICM and Derivation methods Characterization of the embryonic stem cells and the importance of the pluripotency of these cells The different differentiations assay on stem cells and what is ongoing in this field The immunorejection problem and the production of isogonics embryonic stem cells by somatic cell nuclei transfer or therapeutic clone (SCNT) Finally the students will improve their capacity to produce coherent, logical and concise explanations of data and concepts both written and oral, through consideration of the course material. Students will also develop their ability to criticize scientific literature related with ART and reproduction physiology in a constructive and informed fashion Kursens innehåll : Divide in lectures and laboratory work Sperm theory (lecture) 1. Anatomy of the testis, sperm production and maturation, fertilization. 2. Cryopreservation of spermatozoa. 3. Sperm preparation for IVF and ICSI, criteria for ICSI. Embryology ( Lecture) 1. Follicle growth and maturation, ovulation. 2. Cell biology and oocyte genetics. 3. Embryo development invitro, morphological evaluation of embryos. 4 Cryopreservation of embryos, theory and practice. 5. Embryonic stem cells. 6. Selection of embryos for transfer and cryopreservation. Laboratory 1. How to work with sperm, oocytes and embryos. 2. Manipulation and training with mouse oocytes and mouse embryo handling. 3. Micromanipulation techniques, presentation. 4. Micromanipulation training. ICSI and embryo biopsy. Genetics (Lecture) 1. Genetic aspects of prenatal diagnostics and PGD. 2. Cloning techniques. Course test, evaluation, discussions and closing of course. Arbetsformer : Course organization The course runs for one weeks with lectures before lunch and practical training in the afternoons. José Inzunza and Julius Hreinsson are responsible for organizing the lectures and literature projects; and the practical training of the participants and the laboratory work. Teaching laboratories at Södertörns Högskola will be used for the training in embryological techniques. Examination : Writing individual. Obligatoriska moment : The laboratory parts are obligatory. Not attendance of the laboratory activity; student should present a literature work related with the subject of the missing activity. Antal studenter : 10 17 Urval av studenter : The selection is based on the usefulness of the course for the doctoral students' research projects, and the written motivation of the applicants, as to why they want to take the course. Övrig information : The course will be held at Karolinska Institute, Department of Biosciences and Nutrition, NOVUM, Huddinge Kursansvarig : Jose Inzunza Institutionen för biovetenskaper och näringslära 08585 850 93 [email protected] Hälsovägen 7, Novum 141 86 Stockholm Kontaktpersoner : Kenny Rodriguezwallberg Institutionen för onkologipatologi 0858580000 kenny.rodriguez[email protected] Reproduktionsmedicin Karolinska Universitetssjukhuset Huddinge 141 86 Stockholm Title : Advanced seminars in Tumor Biology Kursnummer : 2000 Antal högskolepoäng : 3.0 Datum : 20150901 20151222 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Kursens lärandemål : As a result of the course particiants will be able to understand and discuss advanced problems in cell and tumor biology beyond that of textbooks. The participants will improve their capacity to evaluate and discuss problem solving amd which methods to choose, outside their own area of competence. In particular they shall be able to discuss and evaluate new data in these areas. Participants will get an uptodate overview of cutting edge knowledge beyond textbooks, due to the rapid progress of the field. This is achieved by seminars lead by national or international scientists, and with teachers among the course organizers. Questions and discussion after the presentation by the speaker. Kursens innehåll : The course will cover the frontiers of research in some essential parts of tumor biology and experimental oncology. Subjects that are usually covered deal with cell cycle, apoptosis, signal transduction, cancer genetics, epigenetics incl histone regulation, cancer stem cells, proteomics incluing ubiquitin regulation, tumor immunology, infections and cancer, mathematical modelling, angiogenesis, cell cell communication, tumor heterogeneity, tisue biology and tumor microenvironment, new treatment concepts, and problems in clinical cancer research. Arbetsformer : Lectures and/or seminars in groups followed by discussions including the students once a week. Occasionally litterature studies with research articles associated with the seminars. Totally appr 18 weeks with some 20 seminars, and two meetings in a smaller group. Examination : Written examination at the end of the course («home exam»). Questions of «essay»type to test understanding and scientific maturity, incl some tests of subject knowledge. In addition to the home exam the participants are evaluated according to their activity during the seminars' Q&A sessions/discussions. Obligatoriska moment : The seminars and the meetings in smaller groups are compulsory. Lack of attenandance at single events will be compensated in ways agreed with the course leaders. Antal studenter : 8 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Seminars on Tuesdays every week between 13.00 appr 14.30 at Seminar room A 302, MTC, Nobels väg 16, KI Campus, Solna. In addition Bonus seminars may be offered occassionally as a replacement for the Tuesday seminars. Kursansvarig : Ingemar Ernberg Institutionen för mikrobiologi, tumör och cellbiologi +46852486262 [email protected] Box 280, Karolinska Institutet 17177 Stockholm Kontaktpersoner : Anita Göndör Institutionen för mikrobiologi, tumör och cellbiologi 08 524 862 03 [email protected] Margareta Wilhelm Institutionen för mikrobiologi, tumör och cellbiologi 08524 874 74 [email protected] Elena Kashuba Institutionen för mikrobiologi, tumör och cellbiologi 08524 862 59 [email protected] Title : What is life? The future of biology. Kursnummer : 2001 Antal högskolepoäng : 2.0 Datum : 20150916 20160217 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Kursens lärandemål : After the course students shall be able to discuss: 1. Theories about complexity of biological systems 2. How biocomplexity can be studied. 3. What is the place of computational simulations in modern biology? How simulations can be done? What the predictive power is. How mathematics can be used in simulating biological phernomena. 4. How one understands the organizational principles of biological systems. If selforganization is a field for study or just a trivial phenomenon. 5. How evolotionary theory can be formalized into mathematical models. 6. If quantum mechanical theory can have a role in molecular biology. 7. How genetic information can be converted to mechanical or electrical force in biological system. The students will also aquire an understanding of the conceptual and technical challenges in future biomedicine and advance your ability to ask scientific questions and identify significant and possible areas for problem solving. Kursens innehåll : Inspired by the seminal book by Erwin Schrödinger What is life? published 60 years ago we will adress this question again, in view of the impressive development since then. There are many new concepts to consider in the future of biology, such as the consequencies of the omics era, complexity, computation and simulation, as well as the role of mathematicss and physics in biological theory. The course will cover areas such as biocomplexity, quantum mechanical theory in biology, computation and simulation (in silico biology), organization of biological systems, causality in biology, how does chemistry become electric and magnetic forces and evolutionary theory in the light of molecular biology. Leading scientists with an overview perspective will be invited to discuss in the seminar form the challenges that meet us today in biology, as a result of the omics era, the availability of large amounts of data as a result of high throughput techniques, and the possibilities provided by mathematics, simulation theory and computational biology. Young scientists in this areas are also invited to lecture from their perspective. Invited experts will review these areas in lectures. They will also meet the students for an additional two hours in a workshop discussion of basic concepts. Arbetsformer : Two seminars+worskhop every month for five months, 2,53 hrs on each occassion. Every occasion consists of a appr 12 hour seminar/lecture with the invited expert followed by a two hour open discussion, i.e 34 hours on each occassion. For each seminar the students will usually be given at least one article on the topic to read. Active participation in discussions in groups with invited speaker of high international standards is a key element. You also receive DVDrecordings of all lectures for further self studies at home. Examination : Continuous by workshop discussions. Written homeexam (essay). Obligatoriska moment : The seminars are compulsory. Absence can be compensated for after discussion with the course leader. Antal studenter : 8 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Lectures 12 times/month followed by discussion with the invited speaker, altogether 3 hrs/occassion. Venue is one of the lecture halls at KI Campus, and discussiions at the seminar room A 302 at MTC, Nobels väg 16, KI Campus, Solna. Kursansvarig : Ingemar Ernberg Institutionen för mikrobiologi, tumör och cellbiologi +46852486262 [email protected] Box 280, Karolinska Institutet 17177 Stockholm Kontaktpersoner : Yvonne Strandberg Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Title : Pathology Kursnummer : 2044 Antal högskolepoäng : 3.0 Datum : 20151019 20151030 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Laboratory Medicine Särskild behörighet : Kursens lärandemål : After the course the student should understand basic pathological events and be able to analyze the connection of these events to the development of diseases. Kursens innehåll : The course is divided into two parts. The first part illustrates cell injury, adaptation, tissue repair and inflammation. New methods in cellular and molecular pathology will be discussed. During the second part of the course will focus on tumor development and malignancy. We will discuss how basic pathological responses to inflammation or injury might be the first steps on a multistep path to malignancy. Arbetsformer : This is a full time course with lectures, seminars, demonstrations and microscopy exercises. Examination : Written examination. Obligatoriska moment : Demonstration/microscopy, microscopy practice, pathology "tour" and project work are compulsory. Absence must be compensated with a written report. Antal studenter : 16 30 Urval av studenter : 1)Documented knowledge in areas such as human tissue biology, cell biology or physiology (this kind of knowledge is a prerequisite to be able to benefit from the course). Those who already have studied pathology earlier (for example medical doctors) are not prioritized. 2)Date of admission to doctoral studies (those who have been admitted longest time ago have priority). Övrig information : Kursansvarig : Barbro EkRylander Institutionen för laboratoriemedicin 0858586444 Barbro.Ek[email protected] Kontaktpersoner : Arja Kramsu Institutionen för laboratoriemedicin [email protected] Barbro EkRylander Institutionen för laboratoriemedicin 0858586444 Barbro.Ek[email protected] Title : Current Topics in Infection Biology Kursnummer : 2074 Antal högskolepoäng : 1.5 Datum : 20150902 20151216 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Huddinge Särskild behörighet : Kursens lärandemål : After the course, students should have increased their knowledge of various topics within the field of infection biology such as hostpathogen interactions including viruses, bacteria, parasites etc, innate immune factors, signalling pathways, antigen presentation, generation of cellular and humoral immune responses, as well as aspects of vaccine and antimicrobial treatment development. The goal is that the students to be able to critically analyze data and concepts presented at the seminars within the course, and to discuss the data with the invited speakers. Since the lectures presented span over several subtopics all the students should also be able to gain new information on frontline research activities relevant for their own research project and PhD studies. Kursens innehåll : The course is built up by a series of weekly seminars by invited speakers (international and national) presenting their current research in infection biology. The speakers will both give a basic introduction to their field and present their own research and discuss that in the context of the field as a whole. The lectures will cover host/microbe interactions, routes and mechanisms of infection, the susceptibility and the response of the host to such infections, and the molecular and physiological events leading to the clearance of microbes or a diseased state. Innate and adaptive immunity, inflammation, and the biology of membranes and receptors will also be presented and discussions. Arbetsformer : The seminars are one hour long and are held weekly as part of a seminar series held. A total of 1520 seminars will be held during the semester. Examination : To ensure that the examination is at the individual level, each student is required to read the review articles provided by each speaker and summarize and critically analyze one seminar in a written report. Obligatoriska moment : Attendance at the seminars is compulsory to pass the course. If a student is unable to attend some seminars, she/he can compensate by summarizing and analyzing additional seminars in a written report to make up for the absence. Antal studenter : 5 25 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Seminars will be held on Wednesday 13.0014.00 at the Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge. Kursansvarig : Yenan Bryceson Institutionen för medicin, Huddinge +46858581158 [email protected] Centrum för Infektionsmedicin, F59 14186 Stockholm Kontaktpersoner : Title : Forskningsetik Kursnummer : 2132 Antal högskolepoäng : 1.5 Datum : 20150825 20150915 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department for Clinical Science, Intervention and Technology Särskild behörighet : Kursens lärandemål : Få en inblick i och förståelse av centrala forskningsetiska teorier, principer och riktlinjer och därmed få möjlighet att reflektera över etiska aspekter av den egna forskningen. Målet är också att den forskarstuderande ska få en bättre förståelse av vad som är god vetenskap samt var gränserna går för vad som är etiskt oacceptabel forskning både vad gäller försök med människor och med djur, samt vad som gäller för forskarens egen hederlighet. Kunskap och förståelse: Den forskarstuderande ska efter att ha gått kursen kunna 1. redogöra för forskningsetiska teorier, principer och till viss del riktlinjer, 2. visa kunskap angående vanliga forskningsetiska problemsituationer och de etiska verktygen som kan användas för att hantera forskningsetiska konflikter Färdigheter: Den forskarstuderande ska efter att ha gått kursen kunna: 1. analysera forskningsetiska konflikter, 2. ge hållbara forskningsetiska argument för eller mot ett förfarande Förhållningssätt: Den forskarstuderande ska efter att ha gått kursen ha: 1. utvecklat ett forskningsetiskt förhållningssätt till andra forskarstuderande, handledare och seniora forskare, 2. förståelse för hur ett etiskt förhållningsätt uppfattas hos allmänheten Kursens innehåll : Att ge en introduktion till etiken i samband med forskning och en orientering om dess tillämpning på problem inom det vetenskapliga området. Kursen behandlar bl.a. följande teman: centrala etiska principer, teorier och argument, forskningsetik/forskaretik, grundläggande värderingar och normer för god sed i forskningen, innehåll i och värdet av regelverk så som Helsingforsdeklarationen dess funktion, tillämpning, möjligheter och begränsingar, etikprövningar, avvikelser från värderingar, forskningsfusk och vetenskaplig oredlighet. Det informerade samtyckets historia och komponenter. Försöksdjursetik, innefattande argument för och emot att använda olika djur för forskningsändamål samt de 3 R:en. Hantering av vetenskapligt författarskap (medförfattarskap, författarordning) och intressekonflikter i forskningen. Arbetsformer : Föreläsningar (ca 6t), gruppövningar, seminarier(ca 8t) och muntlig och skriftlig presentation Examination : Examination består av aktivt deltagande i seminarier, ett kortare skriftligt PM där ett tema inom ramen för kursen behandlas. Detta PM presenteras också muntligt för de andra kursdeltagarna. Doktoranden förväntas relatera temat till det egna avhandlingsarbetet. Godkänd kurs innebär aktivt deltagande i seminarier och godkänd muntlig och skriftlig presentation av examinationsuppgiften. Obligatoriska moment : Obligatoriskt är att delta vid introduktionstillfället och vid seminarier. Vid frånvaro kan detta kompenseras med utökat PM skrivande och muntlig presentation för kursen eller kursgivare. Antal studenter : 15 20 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : Kursansvarig : Sigridur Kalman Institutionen för klinisk vetenskap, intervention och teknik 08585 817 87 [email protected] Kontaktpersoner : Carol Melton Institutionen för klinisk vetenskap, intervention och teknik [email protected] Title : Vetenskapsteori Kursnummer : 2133 Antal högskolepoäng : 4.5 Datum : 20151006 20151201 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department for Clinical Science, Intervention and Technology Särskild behörighet : Kursens lärandemål : Efter kursen skall kursdeltagaren ha en bred kunskap i vetenskapsteori samt förmågan att självständigt reflektera över och kritiskt diskutera vetenskapsteoretiska problem i vetenskapligt arbete, för både den egna forskningsuppgiften och forskning i allmänhet. Kursens innehåll : En introduktion till vetenskapsteorin och en förståelse för olika slag av vetenskapligt kunskapssökande. En grundläggande orientering om vetenskapsteoretiska frågor ges. Följande teman behandlas: begreppet kunskap, vetenskap pseudovetenskap, hypoteser hypotesprövning, orsaker förklaringar, vetenskap ¿ värderingar samhälle. Arbetsformer : Föreläsningar (ca 12 t), gruppövningar, seminarier (ca 14 t) och muntlig och skriftlig presentation. Examination : Examination består av aktivt deltagande i seminarier, i ett skriftligt PM där ett tema inom ramen för kursen fördjupas och behandlas mer utförligt, och genom att detta PM presenteras muntligt för de andra kursdeltagarna. Doktoranden förväntas relatera temat till det egna avhandlingsarbetet, alternativt andra (centrala) forskningsfrågor inom den egna disciplinen.Godkänd litteraturredovisning vid seminarier samt godkänd muntlig och skriftlig presentation av examinationsuppgift krävs för godkänd. Obligatoriska moment : Obligatoriskt är att delta vid introduktionstillfället och vid seminarier. Vid frånvaro kan detta kompenseras med utökad muntlig och skriftlig presentation vid seminarium eller för kursgivaren. Antal studenter : 15 20 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : Kursansvarig : Sigridur Kalman Institutionen för klinisk vetenskap, intervention och teknik 08585 817 87 [email protected] Kontaktpersoner : Carol Melton Institutionen för klinisk vetenskap, intervention och teknik [email protected] Title : Infectious Disease Epidemiology Kursnummer : 2135 Antal högskolepoäng : 1.5 Datum : 20151012 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medical Epidemiology and Biostatistics Särskild behörighet : Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology" and "Biostatistics I: Introduction for epidemiologists", respectively, or corresponding courses. Kursens lärandemål : Participants are expected to have a basic knowledge of epidemiological tools, and the course aims to show how these tools apply to the study of infectious diseases. After successfully completing this course you as a student are expected to be able to: explain the concepts and terms used in infectious disease epidemiology list the steps of an outbreak investigation describe the functions and problems of a surveillance system design a simple model for an epidemic explain how population mixing patterns influence epidemic spread design a study to test the effectiveness of a vaccine discuss the important determinants of the antimicrobial resistance problem discuss national and EU systems to control infectious diseases Learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Kursens innehåll : Definitions; immunity; transmission routes; outbreaks; vaccinology; surveillance; models and mixing patterns; specific examples, such as antimicrobial resistance; control systems. Arbetsformer : Lectures, group discussions, computer simulations, case studies. Examination : To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methods used are group assignments along with written and oral individual tasks. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered Obligatoriska moment : Only the examination tasks are compulsory. Antal studenter : 12 25 Urval av studenter : Selection will be based on 1) the relevance of the course for the applicant's project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). Submit a completed application form and give all information requested, including a short description of current research, motivation for attending and an account of previous courses. Övrig information : Kursansvarig : Johan Giesecke Institutionen för medicinsk epidemiologi och biostatistik 0858601210 [email protected] Kontaktpersoner : Gunilla Nilsson Roos Institutionen för medicinsk epidemiologi och biostatistik 08524 822 93 [email protected] Title : To communicate science in different contexts Kursnummer : 2144 Antal högskolepoäng : 3.0 Datum : 20150916 20151001 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : After the course the student is expected to be able to: 1. Orally present own research adapted to different target groups. 2. Reflect on presentation skills and ability to adapt to different target groups. Kursens innehåll : During the course each participant will be given the opportunity to develop practical and theoretical knowledge in: Communication, perception and learning Presentation techniques Rhetoric Use of different media (such as Posters, Overheadprojector, PowerPoint, Whiteboard) Each course participant will perform three oral presentations and receive feedback on content, presentation skills and adaptation towards target group. Arbetsformer : The course design is based on reflective practice and includes selfdirected learning, lectures and literature seminar to process theoretical knowledge, and practical training in presentation skills. Examination : The assessment consists of two different tasks: 1. Reflective statement based in experience, feedback and research/literature within communication and learning. 1. Oral presentation in a popular scientific context supported by PowerPoint or similar. To pass the course the participant needs to show evidence that they reached the learning outcomes by fulfillment of the assessment criteria. Obligatoriska moment : Compulsory sessions are: 1. Oral presentation in a popular science context (video recorded) 2. Oral presentation in a scientific context and observe and give feedback to an oral presentation made by a peer. Absence from the compulsory sessions or assessment seminar can be compensated through supplementary activity. Antal studenter : 20 40 Urval av studenter : The selection for this basic general science course will be based on your admission date to doctoral education (priority given to earlier registration date). Please make sure that you have entered the correct registration date for doctoral education in your personal profile. Övrig information : This is a two week course which requires time for independent work outside of scheduled class time. Scheduled class room sessions are on the following dates: 1617 September, 2324 September, 30 September and 1 October. The course is given in ENGLISH. Kursansvarig : Cormac Mcgrath Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Ingrid Smedberg Institutionen för lärande, informatik, management och etik 08524 837 89 [email protected] Title : Cardiovascular Epidemiology Kursnummer : 2154 Antal högskolepoäng : 1.5 Datum : 20151019 20151023 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Kursens lärandemål : Students having successfully completed the course are expected to recognize different risk factors or risk indicators for cardiovascular disease and different cardiovascular phenotypes. Students should be able to discuss the study designs most commonly used within cardiovascular epidemiology. In addition, students should be able to interpret study results critically. Kursens innehåll : Overview and discussion of risk factors/risk indicators environmental, genetic and biochemical. Discussion of theories and concepts related to common epidemiological and genetic study designs cohort, casecontrol, and genetic association studies. Arbetsformer : Lectures (cathedral) Group work, to consolidate and reflect upon concepts introduced during the course. Seminars. Examination : Learning outcomes will be assessed using 1) a short individual written examination covering different research methods used within cardiovascular epidemiology, and 2) a written group examination. Obligatoriska moment : Participation in group work and article seminars is mandatory. Compensation through an individual written assignment. Antal studenter : 12 25 Urval av studenter : Eligible doctoral students will be prioritized according to 1) the relevance of the course for their research 2) the stated motivation for attending the course. We carefully consider your motivation to attend the course. There will be no selection based upon type of education and background knowledge, however we will use this information to divide student in groups for the group works, so please indicate it in your application. Övrig information : The course takes place at the Institute of Environmental Medicine (IMM), from 9 am till 4 pm Monday to Friday. There will be lectures in the morning and group works in the afternoon. Kursansvarig : Karin Leander Institutet för miljömedicin 0852487498 [email protected] Box 210 (Nobels väg 13), KI 171 77 Stockholm Kontaktpersoner : Ida Kettley Cronfalk Institutet för miljömedicin [email protected] Title : Basic Tumor Histopathology Kursnummer : 2166 Antal högskolepoäng : 1.5 Datum : 20150914 20150925 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of OncologyPathology Särskild behörighet : Kursens lärandemål : At the end of the course the participants should be able to: Distinguish normal from malignant cells in tumor tissues and be acquainted with the morphology/histology of the different tumor types, differentiation stage and tumor grade. Recognize cellular processes in the tumor tissue and its microenvironment like mitosis, cell proliferation, pleomorphism, lineage differentiation, tumor stage, necrosis, apoptosis, neural and vascular invasion, vascularisation. Understand ethical issues and legislation concerning biobanking and practical issues on tumor handling. Kursens innehåll : Tumor histopathology and grading. Introduction. Endocrine tumors. Breast tumors. Prostate tumors. Gastrointestinal tumors. CNS tumors. Hematological malignancies. Sarcoma. Gynecologycal cancers. Tumor handling and biobanking. Arbetsformer : The first day will include an introductory lecture covering general aspects of tumor morphology/histopathology and grading. In the following days we will review one tumor diagnosis per day organized in 45 min introduction , followed by 2 hrs interactive microscopy sessions using a multiheaded microscope and a digital screen, guided by pathologists expert in each field. Home exercises consisting on digital images of tumors together with the clinical history are given at least twice to the students for training. For distribution of files and examination we use KI Box. Examination : The students will get different case studies including digital images from tumors tissues and their clinical history via the KI Box account of the course. The students will then examine the cases and provide a writen description of the relevant observations leading to a correct diagnosis and answers. Images and questions have been provided by each teaching pathologist. When appropriate, antiplagiarism tools will be used according to the guidelines from the Board of Doctoral Education at KI. Obligatoriska moment : 100% attendance is recommended, due that each session is exclusive and cannot be compensated for later on. The student will be asked to review the issue presented in case of absence in a session. Antal studenter : 7 17 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The lectures take place at the lecture hall at Cancer Centrum Karolinska or Radiumhemmet. The microscopy session take place at the Division of Tumor Pathology, at Radiumhemmet. Entrance from CCK floor 2. Kursansvarig : Bertha Brodin Institutionen för onkologipatologi 51775244 [email protected] Cancer Centrum Karolinska CCK R8:00 171 76 Stockholm Kontaktpersoner : Bertha Brodin Institutionen för onkologipatologi 0851775244 [email protected] Title : Cellular and molecular infection biology Kursnummer : 2176 Antal högskolepoäng : 3.0 Datum : 20151026 20151106 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Kursens lärandemål : After the course the students will have an overview of the various aspects of microbial infections with bacteria, viruses and parasites. The students will have knowledge on the level of current understanding of the cellular and molecular mechanisms used by pathogenic microbes, since the course will provide "stateoftheartlevel" presentations in selected aspects of a hostpathogen interaction. The students will be able to give examples of interdisciplinary studies in the research field of microbehost interactions, many lectures focus on interdisciplinary themes such as microbecell interactions, microbial manipulation of host inflammatory responses, pathogen transmission and novel techniques to study microbehost interactions. Analytical and critical thinking will be encouraged by the course design. The students will also have an improved capability for scientific discussions, since the course provides the possibility to interactive discussions with invited teachers, who will attend the student presentation. After the course the students will have a more holistic picture of infection biology, and hopefully they will be encouraged to apply such new information for the benefit of their further graduate training and even get significant input for their own research. Kursens innehåll : Microbial pathogenesis, the interplay between microbes and various host responses and transmission of pathogens Arbetsformer : The course consists of lectures by inhouse and invited speakers on various topics in the discipline of cellular and molecular infection biology. Presentations will cover basic aspects of the research topic that will provide the students with a foundation in the subject. In addition, the more advanced part of the lecture will present stateoftheart research. Groups of students will prepare a seminar and another group will act as ¿opponents¿ to critically analyse the presentations. The students will subsequently participate in interactive studentdriven discussions which includes the invited teacher. Examination : The students will be assigned a series questions based on topics that have been discussed during the course in a written examination. Obligatoriska moment : The compulsory parts of the course are preparation and attendance of the lectures and the student group presentations. If the students cannot attend a lecture they should write a summary based on the course literature for this lecture. There will be a written examination at the end where the students should discuss a given problem within microbial pathogenesis and microbehost interactions. Antal studenter : 10 40 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course will be held at the Department of Microbiology, Tumor and Cell Biology (MTC). It will include lectures from International, National and local researchers in the fields of Bacteriology, Virology and Parasitology. Kursansvarig : Keira Melican Institutionen för neurovetenskap [email protected] Kontaktpersoner : Benjamin Libberton Institutionen för neurovetenskap [email protected] Gerald McInerney Institutionen för mikrobiologi, tumör och cellbiologi 08 52486951 [email protected] Nobels väg 16 17177 Stockholm Keira Melican Institutionen för neurovetenskap [email protected] Title : How to make genetically modified mice for immunological research Kursnummer : 2186 Antal högskolepoäng : 1.5 Datum : 20150907 20150911 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : Kursens lärandemål : After taking the course the student should have an in depth knowledge of how to make genetically modified mice. In summary, the student will aquire enough practical and theoretical knowledge to allow them to independently make genetically modified mice. Specifically, the student will know how to design and make DNA constructs for gene targeting and transgenesis, how to design and perform genotyping using Southern blotting and PCR, and finally how to use the modified mice in immunological experiments. Furthermore, after the course the students will know how to critically analyse experiments presented in the scientific literature and judge their scientific quality. Kursens innehåll : 1) Gene targeting and transgenesis in general: a) a short history of gene targeting and transgenesis in mice, b) when is gene targeting or transgenesis suitable for immunological experiments?, c) overview of the work process. 2) Designing and making constructs for gene targeting and transgenesis. a) how to obtain the necessary information for designing a gene targeting construct, b) different approaches to make DNA constructs for gene targeting and transgenesis 3) Conditional gene targeting. 4) Common problems in gene targeting and transgenesis, and how to solve them. 5) How to use genetically modified mice in immunological research Arbetsformer : Lectures will be the main form of teaching during the course. However, a workshop and a homework assignement will also be part of the course. In groups of three, the students will design a gene targeting project from start to finish and present their research plan. Examination : Active participation in the workshop and the scientific quality of the homework assignement will be the main criteria for the examination of the students. Obligatoriska moment : The homework assignement is compulsory. The homework can alternatively be handed in later in written form. Antal studenter : 12 16 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Alexander Espinosa Institutionen för medicin, Solna [email protected] Kontaktpersoner : Lisa Westerberg Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Alexander Espinosa Institutionen för medicin, Solna [email protected] Title : Developmental biology for regenerative medicine Kursnummer : 2188 Antal högskolepoäng : 3.0 Datum : 20150831 20150911 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Cell and Molecular Biology Särskild behörighet : Kursens lärandemål : After the course, the students should know the basics of stem cell biology and the medical use of cell therapy. The students should be able to describe and understand the theoretical basis for key technologies utilized in stem cell research. Kursens innehåll : The course covers key concepts in translational research from the laboratory to the clinic, including an advanced review of descriptive and molecular developmental biology. Arbetsformer : The pedagogic learning activities on the course consist of cathedral lectures, group discussions and student presentations. Examination : The students are examinated individually with a quiz or a written essay. The final course examination is a project presentation in groups. Obligatoriska moment : Participation in the group discussions and student presentations is mandatory. Compensation through an individual written assignment. Antal studenter : 5 8 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is organized by the Research School of the Linné Center DBRM (Developmental Biology for Regenerative Medicine). More course information can be found at the Research School web pages at www.dbrm.se. The course is full time and the course venue is the seminar room A216 at CMB, Berzeliusv 35. Kursansvarig : Matti Nikkola Institutionen för cell och molekylärbiologi [email protected] Kontaktpersoner : Title : Live cell imaging Kursnummer : 2283 Antal högskolepoäng : 3.0 Datum : 20151005 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Cell and Molecular Biology Särskild behörighet : none Kursens lärandemål : After passing the completed course, the students will be familiar with the basic principles of fluorescence microscopy and diverse live cell imaging techniques. They will be competent in independently designing and performing live cell imaging experiments and understand the possibilities/limitations of different live cell imaging techniques. Kursens innehåll : Basic principles of fluorescence microscopy and live cell imaging. Confocal Laser Scanning Microscopy Deconvolution fluorescence Microscopy Basic principles of advanced fluorescence techniques. Design and perform live cell imaging experiments. Data analysis and presentation. Arbetsformer : The pedagogic learning activities on the course consist of lectures, research seminars, laboratory work (imaging), group discussions, data processing and student presentations. Examination : The students are examinated through 1) an individually written assigment (case study), 2) a practical session and 3) a poster presentation. Obligatoriska moment : All activities (lectures, research seminars, laboratory work, group discussions, data processing and student presentations) are compulsory. If students are unable to attend they have to discuss with course organizer how this can be compensated. Compensation of the laboratory work is not possible. Antal studenter : 8 16 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course will cover theoretical and practical work on different fluorescence microscopes (confocal laser scanning microscopy, deconvolution fluorescence microscopy, grid confocal microscope) focused on live cell imaging with the application of various fluorescence techniques (Fluorescence Restoration After Photobleaching, Fluorescence Loss Induced by Photobleaching, photoactivation, fluorescence resonance energy transfer). The course includes introduction lectures, 23 research seminars from international speakers, and handson sessions at different fluorescence microscopes. Kursansvarig : Matti Nikkola Institutionen för cell och molekylärbiologi [email protected] Kontaktpersoner : Title : Clinical achievements of reproductive medicine Kursnummer : 2291 Antal högskolepoäng : 1.5 Datum : 20150921 20150925 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department for Clinical Science, Intervention and Technology Särskild behörighet : Kursens lärandemål : The objectives of this course are that at the conclusion of this course students should be able to have a comprehensive view of: The key factors involved in gamete biology, gamete physiology and in vivo and in vitro fertilization The key factors involved in early embryo development and implantation The clinical achievements of modern reproductive medicine and Assisted Reproduction Techniques (ART) The causes of subfertility and infertility and the current therapeutic approaches The link between genetics and male/female infertility and the implications in ART The difference between chromosomal and DNAbased genetic disease and the different technologies to detect them The basic genetic technology used in Preimplantation Genetic Diagnosis (PGD) The in vitro systems, culture systems and work stations used in ART The influence of the laboratory and clinic environment on embryo culture The assessment of developmental potential and the morphological aspect of normal oocytes, zygotes, cleavage stage embryos, morulae and blastocysts The implantation process The pathophysiology of repeated early pregnancy loss and ectopic pregnancy The general aspects, implication and clinical applications of stem cells research The novel development of ART for fertility preservation, cryobiology and transplantation The epigenetic aspects of assisted reproduction Kursens innehåll : Contents: Biology of the gametes, fertilization and early embryo development Normal and pathological implantation, early pregnancy loss, ectopic pregnancy, repeated miscarriage In vitro spermatogenesis and oocyte maturation Clinical investigation and therapeutic approach on female and male infertility Genetics in infertility Gonadal dysgenesia Stem cells research Assisted reproduction techniques (ART) In vitro systems and cultures Cloning. Somatic cell nuclear transfer Clinical aspects of fertility preservation Cryobiology systems for fertility preservation Preimplantation genetic diagnosis Epigenetics in assisted reproduction Experimental reproductive tissue transplantation procedures: ovarian and testicular tissue transplantation transplantation of the uterus Arbetsformer : lectures, seminaries/discussion and laboratory demonstrations Examination : Written examination and discussion Obligatoriska moment : All teaching activities, the laboratory sessions and the lectures are obligatory. In case of not attendance to the activities, students should produce a literature work related with the subject of the missing activity. Antal studenter : 6 12 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is oneweek fulltime and includes laboratory demonstration and visits to the reproductive medicine clinics at Karolinska Unversity Hospital, Huddinge. Speakers are international authorities in clinical and experimental research in reproductive medicine Kursansvarig : Kenny Rodriguezwallberg Institutionen för onkologipatologi 0858580000 kenny.rodriguez[email protected] Reproduktionsmedicin Karolinska Universitetssjukhuset Huddinge 141 86 Stockholm Kontaktpersoner : Kenny Rodriguezwallberg Institutionen för onkologipatologi 0858580000 kenny.rodriguez[email protected] Reproduktionsmedicin Karolinska Universitetssjukhuset Huddinge 141 86 Stockholm Jose Inzunza Institutionen för biovetenskaper och näringslära 08585 850 93 [email protected] Hälsovägen 7, Novum 141 86 Stockholm Title : Basic immunology Kursnummer : 2302 Antal högskolepoäng : 3.0 Datum : 20150915 20151029 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : Kursens lärandemål : To understand basic principles of innate and adaptive immunity and how different components of the immune system cooperate. To be able to relate, compare and understand experimental aspects of immunerelated disease in a clinical perspective. To adapt knowledge gained of the function of the immune system by being able to analyze and discuss an immunological/clinical case (group project). To present the group project and discuss the results as well as work in pairs with clinical cases. Kursens innehåll : The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence against infection, autoimmune and allergic disease or transplantation. Part 1: Introduction An overview of the immune system T cells B cells Antigenpresenting cells Innate vs adaptive immune responses Methods to study immune reactions. Part 2: Immune defence against bacterial and viral infections Primary immunodeficiencies Autoimmune disease Allergy Vaccination Clinical Immunology Transplantation Tumour Immunology Questions and discussions Presentation of projects. Arbetsformer : The course is given fulltime during a total of six days separated into two parts. The teaching is mainly in lecture/seminar form but also includes project work studying cases individually and pairwise, as well as in small groups. The group projects are then presented orally on the last day of the course. The project work requires studies between the two course parts, including meetings with mentors. Course literature (Abbas) and cases are handed out at the course start. An immunological quiz is connected to the different chapters in the book so that the student will be able to digest the relatively big material. The course is designed so that clinically active doctors will be better able to combine it with work in the clinic (Mondays and Fridays contain no scheduled course work) .The purpose of dividing the course into two parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts. Considering the substantial literature requirement plus the cases and project work, we estimate that an extra 32h of study is needed, which is not included in the schedule. Examination : Webbased exam on the course content. Oral presentations of smallgroup project work. At this occasion special attention is given to that all students are actively participating. The clinical cases are examined by written reports. Obligatoriska moment : Project work and attendance at the project presentation is compulsory as well as work with two clinical cases. In the case of absence a separate occasion is organized with presentation for the course organizers. The webbased exam is mandatory. Antal studenter : 12 45 Urval av studenter : Selection of students is based on 1. Date of registration as doctoral student 2.Motivation to attend the course. Övrig information : The course is divided into two parts, consisting of three days each (Tuesday to Thursday 1517 September and 2729 October). Between the two parts the participants perform project work, including meetings with mentors as well as study the literature. Teachers include specialists in different fields of immunology including both basic and clinical researchers: examples: Peter Bergman, Ola Winqvist, Rolf Kiessling, Helena Erlandsson Harris and Guro Gafvelin. Litterature includes Abbas (Basic Immunology) the book is free and is handed out at the course start and clinical cases as well as handouts etc. The course location is at or near the Center for Molecular Medicine (CMM), Karolinska University Hospital in Solna. Kursansvarig : Jan Wahlstrom Institutionen för medicin, Solna 0851770663 [email protected] Lungforskningslab L4:01 Karolinska Universitetssjukhuset, Solna 171 76 Stockholm Kontaktpersoner : Tina Heyder Institutionen för medicin, Solna [email protected] Title : Functional Fluorescence Microscopy Imaging (fFMI) in biomedical research Kursnummer : 2348 Antal högskolepoäng : 3.0 Datum : 20151102 20151113 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Clinical Neuroscience Särskild behörighet : Kursens lärandemål : At the end of the course the student should be able: 1. to use fundamental aspects of molecular structure to describe molecule (matter) interaction with light (electromagnetic radiation) and the emission of fluorescence, and to use this knowledge to discuss fluorescent properties of a fluorophore and different labeling strategies. 2. to understand the fluorescence imaging instrumentation, to define elements of a fluorescent microscope and to describe instrumentation properties in terms of sensitivity. 3. to describe the theoretical background behind fluorescence based methodologies for studying molecular interactions in live cells. Discuss pros and contras in relation to the biological problem studied. 4. to specify instrumental requirements and to design a fluorescence imaging assay for a biological problem of interest. 5. to apply a specific labeling strategy and perform a live cell fluorescence imaging assay. 6. to document experimental work in accordance with Good Laboratory Practice (GLP) guidelines. 7. to communicate the results in written and oral form. 8. to discuss the adequateness of the methodology used in the scientific literature concerned. Kursens innehåll : Fluorescence microscopy and associated techniques are becoming indispensable research tools for investigating molecular mechanisms of biological processes. Versatility of fluorescence based methodologies comes from the multifaceted possibility to characterize fluorescence emission by position, intensity, wavelength, lifetime and polarization. These methodologies bring new biological insight at an unprecedented rate and are of crucial importance for the development of life sciences. The course covers the following topics: Luminescence and the nature of light (Fluorescence, Phosphorescence, Light scattering, RayleighTyndall scattering, Raman scattering); Fluorescent markers and their photophysical properties (Organic fluorescent dyes for covalent conjugation (Rhodamine 6G, Alexa dyes, Cyanine dyes); Quantum dots; Intrinsically Fluorescent Proteins (Aequorea victoria (GFP, YFP), Discosoma coral (DsRFP) and Montipora (Keima) families); Selectively binding and intercalating dyes (DiI, DraQ 5). Labeling strategies for biomedical application. Instrumentation for fluorescence imaging (Light sources, Wavelength selection, Detectors, Readout devices, Sample holders, Problems of high blank values, Cuvettes, Solvents and Reagents, Other contaminants); Quantitation and Sensitivity (Instrumental sensitivity, Method sensitivity, Absolute sensitivity); Factors affecting quantitative accuracy (Adsorption, Photodecomposition, Oxidation, Temperature, pH, Innerfilter effects, Quenching); Fluorescence based methodologies for studying molecular interactions in live cells (FRET, FLIM, FRAP). Singlemolecule detection (Quantitative APD imaging, FCS and FCCS). Nonlinear microscopy (Multiphoton excitation, STED). Spatially resolved fluorescence imaging (STORM, PALM). Arbetsformer : The course includes lectures, laboratory sessions, discussion sessions and a project work. Examination : The final assignment consists of a written project report (5 pages) and an oral presentation of the project report (15 min). Obligatoriska moment : All sessions are compulsory. Please report any absence to the course leader in advance by email. Absence from any part of the course (lectures, laboratory sessions, discussion sessions and exam) is generally not accepted but could in special cases be compensated by an individually tailored additional module and a special written examination organized by the course committee. Antal studenter : 8 12 Urval av studenter : This course is on advanced fluorescence microscopy imaging and spectroscopy techniques for quantitative study of molecular transport and interactions in live cells. Number of participants is limited to 12. Priority will be given to applicants who can concisely (max 250 words) show in their application an urgent need to begin their independent work with these techniques. Övrig information : This is a two week course, with 10 sessions. Each session includes a lecture (1 h), laboratory practice and discussions (3 h) and time for selfstudy. Last session is reserved for assessment. <br /> The total working load for the students is estimated to be 95 h (3 hp).<br /> Experimental exercises are carried out in the fFMI laboratory CMM, L5:02, 020a.<br /> Lectures are conducted in the lecturing hall CMM L8:01, 021. Kursansvarig : Vladana Vukojevic Institutionen för klinisk neurovetenskap 51771797 [email protected] CMM L8:01 17176 Stockholm Kontaktpersoner : Title : Survey of Molecular Endocrinology Kursnummer : 2381 Antal högskolepoäng : 3.0 Datum : 20150928 20151009 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Huddinge Särskild behörighet : Kursens lärandemål : After successfully completing this course, student should have obtained a fundamental knowledge of molecular endocrinology and acquired the following abilities: 1. explain the molecular mechanisms by which peptide and steroid hormones activate their receptors to provoke their biological effects 2. comprehend how the actions of hormones are involved in diseases 3. construct pathways of the endocrine systems that link control and production of hormones in specific tissues with the actions of these hormones in their respective target organs 4. analyse and evaluate scientific reports within the research field of molecular endocrinology 5. develop an indepth comprehensive knowledge of endocrinology from a physiological, cellular, and molecular perspective 6. incorporate knowledge learned from this course to critically evaluated clinical and research case problems relating to molecular endocrinology mechanisms 7. evaluate clinical, translational and basic research articles critically and conceptualize alternative interpretations approaches and theories from primary molecular endocrine principles learned in the course 8. structure principles endocrine concept proposal in hypothesis driven objectives for a research grant 9. prepare for public speaking infront of a scientific audience Kursens innehåll : This course will cover current topics involved in hormone signalling at a cellular and molecular level from receptor interaction to gene response including receptor structure and function interactions with their hormone, second messengers, transcription regulation and autocrine and paracrine feedback signalling pathways. The course will emphasize the critical understanding of how hormones act at the molecular level and why their signalling pathways synergize or antagonize each other under normal and pathological physiological conditions. A survey of current topics in endocrinology will be used to exemplify the concepts of the course such as stem cell commitment and differentiation, the molecular signalling and genetics of embryogenesis; reproductive determination and differentiation; cancer stem cell dedifferentiation and carcinogenesis; hormonal regulation of gene expression, steroid and peptide hormone action via paracrine, autocrine signalling; endocrine mechanisms of receptor interaction, transmembrane and intracellular signal transduction, ionic signalling, and regulation of nuclear gene transcription. Arbetsformer : The course will consist of cathedralstyle lectures to exposure students to fundamental molecular endocrine concepts, current topic seminars to exemplify concepts, and studentled seminars and discussions to allow the students an opportunity to utilize conceptual knowledge within an informal environment. Examination : 1. One studentled presentation and discussion with chosen student partner Teams of two students each will be assigned a current journal article with an emphasis in molecular endocrinology to present to the rest of the class. All articles will be read by the students prior to the presentation. Each team will be assigned a faculty member who will supervise their preparation and understanding of the article to be presented at an assigned date during class. Each team will make a formal presentation on the article and will review, critique and discuss alternative interpretations of the article. (Learning outcomes 4, 6, 7, and 9) 2. one written peer evaluation report Each student will be assigned one team led presentation to critique both presenters and journal article. The critique will be formulated in a grant style format. The student will be expected to review the specific topic within molecular endocrinology that the article emphasizes. Then create a testable question and develop a hypothesis based on the topic. Then develop a methodological approach to prove the hypothesis. The student teams that present the article will be considered experts in that topic and the student will critique their position with in the field. (Learning outcomes 4, 6, 7, and 8) 3. one final exam The final written exam will assess the fundimental principles in the following learning outcomes 1, 2, 3, and 5. Obligatoriska moment : The students are expected to attend all lectures and seminars. They are expected to actively participate in discussions. Missed sessions may be replaced by written tasks adapted to the situation. Antal studenter : 5 25 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : This course will be located on the Solna campus. During lecture days, lectures will be held between 1014. Kursansvarig : John Flanagan Institutionen för laboratoriemedicin 0704816995 [email protected] CMM, L8:01 Andrology and Molecular Endocrinology Units 171 76 Solna Kontaktpersoner : Title : Aktuell Omvårdnadsvetenskap teori och praxis Kursnummer : 2407 Antal högskolepoäng : 4.5 Datum : 20151002 20151120 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Tidigare studier inom vårdområdet och närliggande områden i förhållande till forskningsprojektets inriktning. Kursens lärandemål : Kursen syftar till fördjupning i omvårdnadsämnets begreppsliga och teoretiska grunder, samt granskning och värdering av aktuell omvårdnadsvetenskaplig forskning. Mål för lärande är studerandes tillägnan av omvårdnadsvetenskaplig begrepps och teorigrund samt pågående omvårdnadsvetenskapliga paradigm och diskurser. Studerande ska kunna ställa samman vetenskapteoretiska grunder för teori och begreppsutveckling inom omvårdnad samt kunna tillämpa detta i relation till egen forskningsinriktning. Studerande ska kunna förklara den historiska utvecklingen av omvårdnad som vetenskap och kunna sammanfatta för innehållet i utvalda omvårdnadsteorier Studerande ska kunna kritiskt granska, analysera och värdera utvecklingen av omvårdnadsvetenskapliga begrepp relaterat till egen forskningsinriktning. Kursens innehåll : Vetenskapsteoretiska aspekter på omvårdnadsvetenskap Teoriutveckling och begreppsutveckling inom en vetenskap Metateoretiskt perspektiv enligt Meleis Den Nordiska utvecklingen av omvårdnad/vårdvetenskap Granskning och värdering av aktuell omvårdnadsforskning samt pågående teoriutveckling Arbetsformer : Målen bearbetas genom att studera internationell och Nordisk utveckling av omvårdnadsvetenskap. Exempel studeras på olika forskningsprogram inom omvårdnad vårdvetenskap. Vi bekantar oss med, analyserar och granskar kritiskt, paradigmutvecklingen inom ämnet idag. Kursen bygger på en huvuddel av självstudier av litteratur. Arbetsformerna på campus är seminarier samt föreläsningar. Examination : Litteraturuppgifter på obligatorisk kurslitteratur samt integrativ granskning och analys av omvårdnadsteoretiska grundbegrepp i relation till eget projekt. Obligatoriska moment : Undervisningsmomenten på campus, föreläsningar och seminarier under kursen är obligatoriska. Frånvaro kompenseras genom skriftliga eller muntliga extrauppgifter vilka beslutas av examinator. Antal studenter : 15 30 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : HT 2015 kommer fredagarna 2/10, 16/10, 6/11 och 20/11 vara obligatoriska campus samlingar för kursen. Kursen ges på Alfred Nobels Alle 23 i Huddinge (tågstation Flemingsberg). Kursansvarig : Maria Arman Institutionen för neurobiologi, vårdvetenskap och samhälle 0852483973 [email protected] Kontaktpersoner : Title : Causal Inference for Epidemiological Research Kursnummer : 2416 Antal högskolepoäng : 1.5 Datum : 20151130 20151204 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medical Epidemiology and Biostatistics Särskild behörighet : The students are expected to have taken Epidemiology I, Epidemiology II, Biostatistics I, and Biostatistics II. Exceptions can be made if the students have taken other courses with an equivalent content. Kursens lärandemål : After the course the student will be able to use counterfactuals to express and interpret causal queries be able to judge when standard statistical methodology is appropriate for causal inference, and when it is not be able to use Directed Acyclic Graphs to describe and analyze complex epidemiological scenarios be able to use Marginal Structural Models to analyze longitudinal data, with additional help from a skilled statistician Kursens innehåll : Causal inference from observational data is a key task of biostatistics and of allied sciences such as sociology, education, behavioral sciences, demography, economics, health services research, etc. These disciplines share a methodological framework for causal inference that has been developed over the last decades. This course presents this unifying causal theory and shows how biostatistical concepts and methods can be understood within this general framework. The course emphasizes conceptualization but also introduces statistical models and methods for timevarying exposures. Specifically, this course strives to a) formally define causal concepts such as causal effect and confounding, b) identify the conditions required to estimate causal effects, and c) use analytical methods that, under those conditions, provide estimates that can be endowed with a causal interpretation. The (causal) methods can be used under less restrictive conditions than the traditional statistical methods. For example, causal methods allow one to estimate the causal effect of a timevarying exposure in the presence of timedependent confounders that lie on the causal pathway between exposure and outcome. Arbetsformer : Lectures and group discussions. Examination : There will be a takehome exam handed out at the last day of the course. Students who fail will be given the opportunity to write at a maximum 2 reexams. Dates for the reexams will be announced later. Obligatoriska moment : Antal studenter : 12 25 Urval av studenter : Eligible doctoral students will be prioritized according to 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). To be considered, submit a completed application form. Give all information requested, including a short description of current research and motivation for attending, as well as an account of previous courses taken. Övrig information : Prerequisite knowledge equivalent to "Epidemiology I: Introduction to epidemiology", "Epidemiology II: Design of epidemiological studies", "Biostatistics I: Introduction for epidemiologists" and "Biostatistics II: Logistic regression for epidemiologists" or courses with corresponding learning outcomes Kursansvarig : Yudi Pawitan Institutionen för medicinsk epidemiologi och biostatistik [email protected] Kontaktpersoner : Gunilla Nilsson Roos Institutionen för medicinsk epidemiologi och biostatistik 08524 822 93 [email protected] Title : Methods in molecular biology and their applications in medical research Kursnummer : 2418 Antal högskolepoäng : 3.0 Datum : 20150907 20150918 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Laboratory Medicine Särskild behörighet : Kursens lärandemål : After the course, the students will understand the principles, from both a theoretical and practical viewpoint, of a number of basic techniques used in DNA/protein research and their application in medical research. The students should also be able to design and perform investigations with some of the discussed techniques. Kursens innehåll : The aim of this course is to confer knowledge of how basic molecular biology and protein work can be applied in clinically oriented research work. The course is designed for graduate students with limited experience of molecular biology and combines a lecture program with laboratory work. The lectures will include theoretical and practical aspects on basic concepts concerning techniques in molecular biology and proteomics and their application in medical research. Specified subjects will include cloning, RNAanalysis, promoter studies, DNAsequencing, expression, bioinformatics, antibody based protein detection and proteomics. The overall objective is to convey knowledge of possibilities and limitations with different techniques and introduce valuable methodology for the students PhDprojects. Arbetsformer : The course combines a lecture program in the morning with laboratory work in the afternoon, where course participants will be subdivided into smaller groups. Examination : The students will be asked to solve a scientific problem using methods they learned during the course. The last day of the course, the participants will give a presentation. They should be able to defend the laboratory design, discuss methodologies applied and anticipated results. The students will work in pairs. The task will be given to the participants at the end of the first week. Obligatoriska moment : Laboratory work is compulsory. To compensate for absence, selfstudies and an written essay on the topic(s) that they have missed must be performed. Antal studenter : 8 14 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course combines a lecture program in the morning with laboratory work in the afternoon, where course participants will be subdivided into smaller groups. Kursansvarig : Agne Kulyte Institutionen för medicin, Huddinge [email protected] Kontaktpersoner : Camilla Pramfalk Institutionen för laboratoriemedicin [email protected] Title : Principles of nucleic acid structure Kursnummer : 2430 Antal högskolepoäng : 4.5 Datum : 20151116 20151204 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Biosciences and Nutrition Särskild behörighet : Kursens lärandemål : After the course, the participants will be able: to describe and to visualize nucleic acid structures. to apply principles regulating nucleic acid structures. to explain the relation between structure and function in nucleic acid molecules to evaluate critically experiments used to provide RNA or DNA structural information. Kursens innehåll : A general introduction to nucleic acids nomenclature. Structural and conformational features of nucleotides. Physical properties. Hydrogen bonding and base stacking. Water and nucleic acid. Metal ion and nucleic acid. Secondary and tertiary structures of DNA and RNA. Methods to determine structures and dynamics of DNA and RNA systems (such as xray crystallography, NMR, theoretical approaches and so on) General consideration on proteinnucleic acid interactions, DNA superhelix, higher order nucleic acid structure. Small introduction to secondary structure predictions, structural database, molecular visualization. Three invited lectures on specific topic. Arbetsformer : The course consist in lectures, seminars, short presentations given by the participants. group activities under the supervision of the course leader, computer tutorials on database and molecular visualization (14 meetings of three hours each) During the course period, the participants will work individually on an written assessment portfolio, give and receive feedback on the written work. In addition, the participants will prepare and discuss a seminar on an assigned topic. The participants should integrate each lectures hour with homework and reading. Examination : A final written exam will be used to assess the participant's ability to describe and apply the structural principles of nucleic acid structures. The seminar and written assessment portfolio will be used to assess the participant's ability to explain the relation between structure and function in nucleic acid molecules and to evaluate critically experiments used to provide RNA or DNA structural information. Obligatoriska moment : The participant must participate actively by attending the lectures and the seminars, by completing the assigned tasks. In addition, the participant must complete the assessment portfolio and final exam. Absence to a lecture will be compensated with extra assignments. The students will get some key questions on the corresponding lecture, and the answers should be submit in written form for review and approval. Antal studenter : 8 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is held at Huddinge Campus. The meetings will be held from 9 to 16 during all the day of week 47, and Thursday and Friday of weeks 48 and 49. A minisymposium will be held on Friday 27th November with national and international experts (see http://www.biosci.ki.se/users/villa/teach.htm for the speakers in the previous occasions). The course is held every 1.52 years Kursansvarig : Alessandra Villa Institutionen för biovetenskaper och näringslära +4686089195 [email protected] Hälsovägen 7 NOVUM 141 83 Huddingen Kontaktpersoner : Title : Clinical Research in Lipid Metabolism Kursnummer : 2433 Antal högskolepoäng : 1.5 Datum : 20151019 20151023 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Huddinge Särskild behörighet : Kursens lärandemål : After the course the students will be able to: 1. Describe lipid and lipoprotein metabolism 2. Understand how to analyze fatty acids, and sterols (by SEC, HPLC and gaschromatography mass spectrometry) 3. Understand principles for subcellular fractionation, enzyme and receptor assays, and molecular biology of proteins in lipid metabolism 4. Describe genetic hyperlipoproteinemias 5. Understand which techniques that can be used in in vivo studies, such as biopsy techniques, microdialysis, and in turnover studies of lipid and lipoprotein metabolism Kursens innehåll : Overview and new developments within the field of clinical research in lipid metabolism. Emphasis will be laid on cholesterol metabolism, lipoproteins, lipoprotein receptors and on the regulation of enzymes involved in biosynthesis and metabolism of cholesterol, bile acids, fatty acids and triglycerides. Genetic diseases and effects of diet on clinical conditions such as atherosclerosis, obesity, diabetes, and gallstone disease will also be highlighted. Arbetsformer : Lectures (24). The participants will also be invited to present their own projects for general discussion on the methodological aspects of their project. Examination : In order to evaluate the students knowledge regarding clinical research in lipid metabolism a written examination consisting of short answer questions and multiple choice questions will be given. Obligatoriska moment : The lectures are not mandatory. However all information presented at the lectures is compulsory and will be a significant basis for the written examination. Antal studenter : 10 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant¿s doctoral project (according to written motivation) and 2) date for registration as a doctoral student (priority given to earlier registration date). Övrig information : The course is held in English and lectures and self studies will correspond to 40 working hours (1.5 ECTS credits). The location is the Red Seminar Room at Novum, Karolinska Institutet, Huddinge Kursansvarig : Mats Rudling Institutionen för medicin, Huddinge [email protected] Kontaktpersoner : Sara Straniero Institutionen för medicin, Huddinge [email protected] Ylva Bonde Institutionen för medicin, Huddinge [email protected] Lena Emtestam Institutionen för medicin, Huddinge [email protected] Title : Public health intervention and implementation research Kursnummer : 2454 Antal högskolepoäng : 7.5 Datum : 20151019 20151120 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Kursens lärandemål : At the end of the course the student should be able to: 1. Define core concepts in intervention and implementation research 2. Understand the concept of evidencebased public health 3. Understand how to critically appraise published intervention and implementation studies, as well as systematic reviews in public health 4. Describe models and frameworks of intervention and implementation research 5. Design an intervention study, which includes a relevant problem theory and a programme theory, appraisal of ethical aspects as well as evaluation design 6. Design the implementation of an evidencebased programme or practice, and describe the evaluation design 7. Understand concepts of fidelity and adaptation Kursens innehåll : As this course aims at giving doctoral students knowledge in theory, method and practice in the field of public health intervention and implementation research, the content focuses on the following themes: 1. Models and frameworks in intervention and implementation research 2. How to apply a theoretical perspective using relevant change theories 3. Intervention and implementation core components, barriers and facilitators 4. Appropriate study designs for process and outcome evaluation 5. Systematic and critical appraisal of published intervention and implementation studies 6. Dissemination of scientific results Arbetsformer : The course is based on lectures in combination with seminars in order to promote a reflective, analytical and critical approach towards this research field. The course will also use group assignments and group discussions to promote the students active participation in their learning process, as well as the ability to accomplish tasks both individually and in groups. All teaching activities aim at enhancing the student's ability to apply for example core concepts and theoretical frameworks, not the least ethical aspects, in an analytical and reflective practice and to apply this on the students own research projects. All teachers in the course are active researchers in the field of intervention and implementation research. Examination : The students' knowledge and skills in theory, method and practice in the field of public health interventions and implementation research will be assessed in relation to the expected learning outcomes through the following examinations: a. Formative assessment during active participation in seminars with presentations, in discussions and short seminar reports b. Summative assessment of a written project report, oral presentation of the report and opposition Obligatoriska moment : Participation in scheduled seminars and group work and examination is compulsory. Absence is compensated through a written summary of the literature for the seminar where the absence occurred. Antal studenter : 12 20 Urval av studenter : Selection will be based on the relevance of the course syllabus for the applicant's doctoral project (according to written motivation) Övrig information : Classroom meetings are scheduled on Mondays and Tuesdays. All teachers involved in the course are active researchers in the field of intervention and implementation research. Kursansvarig : Lydia Kwak Institutet för miljömedicin [email protected] Kontaktpersoner : Johanna Bergman Institutet för miljömedicin [email protected] Nobels väg 13 17177 Stockholm Title : Thrombosis and Hemostasis, from mechanisms to therapies Kursnummer : 2484 Antal högskolepoäng : 1.5 Datum : 20151102 20151106 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : Kursens lärandemål : The concept from bench to bed side and back will be reinforced at all levels. Therefore, at the end of the course the students should be able to: 1. Describe the molecular and cellular mechanisms of haemostasis and thrombosis, as well as the dynamic processes of primary haemostasis, secondary haemostasis, and thrombosis. 2. Explain the mechanisms underlying bleeding and thrombotic disorders. 3. Have a good understanding of current anticoagulant and antiplatelet therapies, and obtain a clear view of the challenges of future anticoagulant and antiplatelet drug developments. 4. Apply current knowledge of thrombosis and haemostasis into future research design and to formulate new treatment strategies. 5. Sharpen the sense of critical appreciation of research literature, and strengthen their ability to develop new research concepts through critical reading. Kursens innehåll : The course aims to bring in indepth knowledge of thrombosis and hemostasis, and to emphasize a translational view, from bench to bed side and back, of the hemostatic system to the students. The course is designed for the students who work in both basic and clinical aspects of hemostasis, thrombosis and cardiovascular research. The following aspects of hemostasis and thrombosis will be discussed: biochemistry of the blood clotting system; cellcell and cellprotein interactions in the cardiovascular system in relation to thrombosis and bleeding disorders; crosstalks of the clotting system with inflammation, host defense and complement systems; diagnosis of bleeding and thrombotic disorders; therapeutic strategies to fight thrombosis and bleeding with the emphasis placed on new pharmacological concepts. Arbetsformer : Lectures Seminars Group work Presentation of papers related to the key lectures Examination : Presentation of a paper related to key lectures Short written homework. Multiplechoice test. Obligatoriska moment : To participate in the lectures, group work and presentation of the group work is compulsory. The students who have missed the group work sessions can book extra session time within 4 weeks to compensate the absence. Absence in lectures should be compensated for in accordance with the course director. Antal studenter : 12 25 Urval av studenter : In case the course receives more applications than the maximal course slots. Selection of the participants is thus needed and made according to: 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) KI doctoral students prior to doctoral students from partner universities; 3) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Course will be held during week 45 (Monday Friday; 9:0016:30). Lecture hall booked: CMM lecture hall, L8:00 at Karolinska University HospitalSolna. Lectures will be given by 14 lecturers who are all wellestablished experts on their lecture subjects. The course has been given at KI over 20 years with about 10 course occasions. The course is well received by the course participants over the years. The course in HT 2014 was highly remarked in the course evaluation (linked). Kursansvarig : Nailin Li Institutionen för medicin, Solna 0851773996 [email protected] Clinical Pharmacology Unit Karolinska University HospitalSolna 17176 Stockholm Kontaktpersoner : Angela Silveira Institutionen för medicin, Solna 0851773224 [email protected] Title : Obesity basic science, clinical and epidemiological aspects Kursnummer : 2498 Antal högskolepoäng : 1.5 Datum : 20151116 20151120 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Public Health Sciences Särskild behörighet : Kursens lärandemål : At the end of the course the students should be able to: 1, Discuss different hypothesis and theories concerning the pathogenesis of obesity 2, Discuss occurence of obesity and co morbid diseases in society 3, Discuss current treatment methods of obesity and effects of these treatments on comorbid diseases 4, Discuss methods to prevent obesity and methods used to evaluate effects of treatment and prevention 5, To relate clinical and public health aspects of obesity to research aspects of obesity Kursens innehåll : The course is to give an overview of obesity in society, pathogenesis and current treatment methods. These clinical examples will be used to demonstrate how one can design various research projects related to obesity and comorbid disease preclinical, clinical, epidemiologcal and preventive projects. Arbetsformer : The course will be based on lectures, work in small seminar groups and demonstration of surgery of obesity. Examination : Written examination Obligatoriska moment : Presence at lectures, group work and demonstration is mandatory. Absence must be compensated by a written task. Antal studenter : 10 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course will take place at Danderyd University Hospital. Kursansvarig : Erik Näslund Institutionen för kliniska vetenskaper, Danderyds sjukhus 086555017 [email protected] Kontaktpersoner : Title : Cancer cell energy metabolism Kursnummer : 2515 Antal högskolepoäng : 1.5 Datum : 20151102 20151106 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of OncologyPathology Särskild behörighet : Kursens lärandemål : After the course, the student should be able to: describe and explain the role of altered cellular metabolism in cancer development and cancer progression; reflect upon the interaction between oncogenic signaling and tumor metabolism; discuss how tumor metabolism may be exploited in anticancer therapies and diagnosis/prognosis. Kursens innehåll : The course provides an introduction to cancer cell metabolism. Focus is on the roles of oncogenic signaling and tumor microenvironment as drivers of tumor development and progression. Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism are discussed. Arbetsformer : The course consists mainly of lectures, but also a minisymposium with invited international speakers and group discussions/seminars. Examination : Examination is divided into two parts: Firstly, during active participation in the Meet the scientists seminar and in connection with the beehive group preparing that. Secondly, the students will be given an individual written assignment to be delivered within two weeks after the end of the course. This assignment is a short project proposal within one topic chosen from a list of 10. The proposal will contain an overview of the field which motivates a specific research question identified by the student and a brief work plan that explains how the question/hypothesis can be solved/investigated. Obligatoriska moment : Attendance at lectures is strongly advised. Participation in the beehive and Meet the scientist session is mandatory. To compensate for absence due to e.g. illness the student may be required to write a report and/or discuss the missed subject with the course leaders. Antal studenter : 10 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Angelo De Milito Institutionen för onkologipatologi 0851771766 Angelo.De[email protected] Forskningsringen 50 17462 Sundbyberg Kontaktpersoner : Mimmi Shoshan Institutionen för onkologipatologi 08517 754 60 [email protected] Title : Basics of Qualitative research Kursnummer : 2518 Antal högskolepoäng : 1.5 Datum : 20150914 20150918 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Clinical Science and Education, Södersjukhuset Särskild behörighet : Kursens lärandemål : At the end of the course the participants will be able: 1. To describe different theoretical starting points for qualitative inquiry 2. To apply knowledge of qualitative research methods for discussing rationales for the design of the qualitative inquiry 3. To critically compare of qualitative and quantitative research (basic assumptions of the qualitative research paradigm as it compares to the quantitative paradigm) 4. To describe the common essential elements of qualitative research including How to select the appropriate: qualitative research methods based on phenomenon of interest setting for data collection,study participants, data generation strategies (including individual interviews, focus group discussion, written narratives, participants observation and field notes)and data analysis method 5. To critically comments on/evaluate the weaknesses and strengths of the studies(published papers) using qualitative research in terms of research question, aim and method 6. To design a qualitative research proposal in the field of health Kursens innehåll : The course will provide some of the most important information which students need to understand and implement successful qualitative research methods (including the common essential elements of qualitative research). In addition the course will provide step by step guidance to examine and apply current qualitative methodologies as a way to generate, manage, analysis qualitative data and moreover ,ethical considerations. The course will starts with the definition of qualitative research, basic assumptions and characteristics of qualitative research in comparison to quantitative research. Following that will be the notion of some common essential elements in qualitative methods such as: selecting the methods based on phenomenon of interest, using the literature review, choosing the setting for data collection, selecting participants, generating data and content analysis .After that , practical principle to do qualitative inquiry will be addressed. Finally ethical considerations in qualitative research will be explained. Arbetsformer : The learning activities on the course are a mix of lectures, discussions, individual and group; interview, seminar, field observation and individual presentations. Examination : The course assessment will include formative and summative assessments. The formative assessment (50%) will be made through Peer learning Activity, critic a qualitative paper, individual and group presentation, while summative assessment (50%) will be through a written examination and individual qualitative proposal. In this way, the students are examined with both groupwise and individual presentations. Obligatoriska moment : Active participation in the class discussions, individual and group assignment (individual and group interview and field observation), written assignment (an abstract of a qualitative proposal) and student presentations is mandatory. Compensation according to the instructions of the course director, which means absence in less than 2 lectures is acceptable and should be compensated by an individual project related to that particular session. Antal studenter : 10 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Hamid Khankeh Institutionen för klinisk forskning och utbildning, Södersjukhuset [email protected] Sjukhusbacken 10 118 83 Stockholm Kontaktpersoner : Jeanette Brynholt Ohrman Institutionen för klinisk forskning och utbildning, Södersjukhuset 086162935 [email protected] Title : Cellular Reprogramming from basal mechanisms to medical applications Kursnummer : 2525 Antal högskolepoäng : 1.5 Datum : 20150914 20150918 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Cell and Molecular Biology Särskild behörighet : Kursens lärandemål : Upon completion of the course, the doctoral student will be familiar with mechanisms of nuclear reprogramming and how reprogramming techniques can be utilized in various research areas. Emphasis will be put on providing the student with knowledge to critically read and evaluate research work in the reprogramming field, as well as on how appropriate reprogramming methods and procedures can be applied in various research projects. Kursens innehåll : The course is composed of lectures that address different aspects of cellular reprogramming, i.e. how cellular identity can be changed, covering both basic scientific mechanisms as well as experimental procedures of cellular reprogramming. The primary focus will be on the reprogramming of fully differentiated cells to induced pluripotent stem (iPS) cells, but direct reprogramming from one differentiated state to another will be discussed as well. Controlled differentiation of pluripotent cells to specific fates and the use of cellular reprogramming in disease modeling will be discussed. Arbetsformer : The learning activities are a mixture of lectures, discussions, group seminars and individual presentations. Examination : The students are examined with individual presentations. Obligatoriska moment : Participation in the group discussions and student presentations is mandatory. Compensation is according to the instructions of the course director. Antal studenter : 10 15 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is organized by the Research School of the Linné Center DBRM (Developmental Biology for Regegerative Medicine). More course information can be found at the Research School web pages at www.dbrm.se. The course is full time, given in English, and the course venue is the seminar room A216 at CMB, Berzeliusv 35. Kursansvarig : Matti Nikkola Institutionen för cell och molekylärbiologi [email protected] Kontaktpersoner : Title : Neuropschopharmacology Kursnummer : 2526 Antal högskolepoäng : 2.0 Datum : 20151123 20151201 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Clinical Neuroscience Särskild behörighet : Kursens lärandemål : By the end of this course the PhD students should: 1) have achieved an understanding of the etiology of psychiatric disorders and are able to account for different hypotheses in this field and how the major psychiatric diseases are treated. 2) possess skills in handling methods and animal models for studying the effects of drugs on different symptoms of psychiatric diseases. 3) be able to evaluate data and preclinical research within the research fields of psychiatric diseases. Kursens innehåll : This course will focus on pharmacological strategies in the treatment of psychiatric disorders, e.g. schizophrenia, major depression etc. The course will also discuss methods and models which are used in preclinical research concerning the mechanisms of action of different drugs in the treatment of these disorders. Arbetsformer : The pedagogic framing of the course include lectures given by invited clinicians and researchers within the field of psychiatric disorders. We will also have demonstrations of key models/methods which are used in specific research projects. Examination : Written exam Obligatoriska moment : The demonstrations are mandatory. The student has to compensate absense from this part with a written description of the model/method. Antal studenter : 15 35 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Kent Jardemark Institutionen för Fysiologi och Farmakologi 0852487918 [email protected] Kontaktpersoner : Vasco Sousa Institutionen för klinisk neurovetenskap [email protected] Title : The major global infectious diseases: tuberculosis and HIV Kursnummer : 2536 Antal högskolepoäng : 1.5 Datum : 20151123 20151127 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : Kursens lärandemål : At the end of the course the students should be able to: describe the disease mechanisms of TB and HIV infection and discuss important differences and similarities between these infections and their impact on global health. explain the challenges regarding clinical symptoms, diagnosis, treatment and drugresistance, vaccine strategies and TB/HIV coinfection. analyse how clinical management of TB and HIV can be integrated and linked to molecular knowledge as well as public health issues. discuss and critically evaluate current issues in TB and HIV research including prevention and control in low, middle and high income countries. Kursens innehåll : An overview of tuberculosis (TB) and HIV/AIDS infection and disease including relevant virology and bacteriology, TB/HIV coinfection, clinical management, international public health aspects, immunology and pathogenesis, diagnostic methods and principles of vaccines, therapy and drug resistance as well as novel research strategies. Arbetsformer : The course will consist of a mixture of lectures by invited speakers, seminars and practical sessions i.e. study questions and group assignments. The students will have access to computer rooms. Examination : Study questions and group assignment will be presented (both orally and in written) and discussed by the students and facilitators on a daily basis. Thus, the individual learning outcome will be assessed on a daily basis. Furthermore, on the last day of the course, concept maps will be used to summarize individual learning outcome. Obligatoriska moment : It is compulsory to attend all the lectures and sessions, including the group assignment. Absence has to be compensated by an individual written assignment provided by the course leader. Antal studenter : 15 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course will take place at Karolinska Universityhospital Solna, at the Center for Molecular Medicine (CMM), MondayFriday 08.3016.30. We plan to invite several speakers from TB/HIV high endemic countries to talk about reallife experiences Kursansvarig : Annelie Tjernlund Institutionen för medicin, Solna [email protected] Jordgränd 44 192 74 Sollentuna Kontaktpersoner : Anne Rasikari Institutionen för medicin, Solna 08517 718 61 [email protected] B3:03 Title : Writing Science and Information Literacy Kursnummer : 2561 Antal högskolepoäng : 3.0 Datum : 20150824 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Karolinska Institutet University Library Särskild behörighet : Kursens lärandemål : Demonstrate understanding of how to write an original scientific article and submit it for publication Demonstrate ability to write other types of texts required for a scientific career Demonstrate ability to give, take, and make use of constructive criticism Demonstrate the ability to search and manage the medical sciences literature in a structured way Demonstrate the ability to use resources which facilitate choosing a journal to publish your research Describe aspects of postpublication evaluation and processing of the medical sciences literature Kursens innehåll : Basic of scientific writing Writing an original scientific paper Supporting the text Writing in other contexts The publication process Searching the literature Managing the literature Choosing a journal Evaluating published science KIpostpublication processing Arbetsformer : This webbased course will be held using the learning management system PingPong. Content will be learnt with various learning objects and learning practised by exercises. Formative feedback will be given by teachers/peer/selfassessment. Writing and IT skills will be developed. Examination : The intended learning outcomes are assessed in the summative examination. Participants will write and rewrite a grant application and popular science summary based on teacher and peer feedback. Participants will also complete a number of assignments which demonstrate their ability to use a number of relevant IT resources in a context of scientific communication. Obligatoriska moment : There will be a number of obligatory tests and assignments to be completed. Antal studenter : 18 22 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : This is an entirely webbased course with teacher support but no physical meetings. The course is read at 25% of fulltime. Kursansvarig : David Herron Karolinska Institutet Universitetsbibliotek 08524 841 13 [email protected] Berzelius 7B 17177 Stockholm Kontaktpersoner : Title : Introduction to R statistical analysis for biologists Kursnummer : 2570 Antal högskolepoäng : 1.5 Datum : 20151109 20151113 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Cell and Molecular Biology Särskild behörighet : Kursens lärandemål : After the completion of the course, the participants will be able to make use of R for exploring and analyzing data sets. More specifically, the participants will be able to manage data sets, perform descriptive data analysis, generate plots for graphical display of data, and to perform tests such as Regression and ANOVA. A very specific goal is to provide the participants with a longterm tool and the guidelines for improving their knowledge on it. Kursens innehåll : Data sets and formats in R. Descriptive statistics. Graphical display of data. Classical tests. Regression, ANOVA, KruskalWallis. Experimental design. Graphical display of analysis. Use of documentation in R. Arbetsformer : The course consists of lectures, computer excercises and project work. Examination : The acquired knowledge and skills will be examined in two ways: by successfully completing computer exercises and by a individual project (analysis of a selected data set; which can be provided by the student). Obligatoriska moment : Attendance is compulsory in lectures and computer excercises. Absence from obligatory moments is compensated according to the instructions of the course director. Antal studenter : 10 15 Urval av studenter : Selection is based on the relevance of the course content for the doctoral project, the personal motivation included in the course application and the date for registration as a doctoral student (priority given to earlier registration date). Övrig information : The course takes place at CMB at KI Solna campus, in the seminar room A216. Entrance Berzeliusv 35. The course director is Dr. David GomezCabrero at the Department of Medicine, Solna. Email [email protected]. Kursansvarig : Matti Nikkola Institutionen för cell och molekylärbiologi [email protected] Kontaktpersoner : Title : Noncoding RNA and cancer Kursnummer : 2583 Antal högskolepoäng : 1.5 Datum : 20151130 20151204 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of OncologyPathology Särskild behörighet : Kursens lärandemål : At the end of the course, the students are expected to be able to: understand the diversity of noncoding RNAs and their importance in tumorigenesis and tumor progression. describe various methodologies for noncoding RNA research, account for applications and apply relevant approaches in their own projects. Kursens innehåll : Noncoding RNAs are key regulators of gene expression with important impact in many biological processes. Recent research has identified different classes of noncoding RNA and their roles in cancer development and progression. Through short introductory lectures and indepth discussion of key papers from the recent literature, this course will cover an uptodate introduction to the biogenesis of diverse noncoding RNAs (including small RNAs and long noncoding intergenic RNAs) and their mechanisms of gene regulation, methodologies for noncoding RNA research, expression and function of noncoding RNAs in cancer development, and their potential clinical implications. Arbetsformer : The course consists of lectures and problembased discussions. In addition, the students are required to submit a research proposal on a topic related to noncoding RNA and cancer. Examination : The examination of the course includes problembased discussions, and reviewing and presenting individual research proposal related to noncoding RNA. Obligatoriska moment : The students are expected to attend all lectures and problembased discussions, as well as to complete all assignments. In the case of absence, the student will be asked to compensate by completing another written assignment given by the course organizer. Antal studenter : 12 20 Urval av studenter : Selection will be based on the relevance of the course to the student's research project and the personal motivation for participation in this course. Övrig information : This fulltime course will be held at Cancer Center Karolinska, Karolinska University HospitalSolna. Kursansvarig : Wengonn Lui Institutionen för onkologipatologi 0851773930 Weng[email protected] Kontaktpersoner : Title : Neurogenetics Kursnummer : 2600 Antal högskolepoäng : 1.5 Datum : 20150928 20151002 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Kursens lärandemål : I) The student will be able to understand and describe the major differences and uses of human genetic studies of neurogenetic diseases using i) Twinstudies, ii) population based studies, iii) casecontrol studies, iv) family studies. Students will have an in depth knowledge and understanding of selected neurologic conditions such as Alzheimer disease, trinucleotide repeat disorders, their genetic basis and an insight into the molecular pathogenesis, if known. II) The students will also be able to describe how genetic studies can be used to increase our understanding of the biological basis of neurological conditions. III) The students will be able to contribute substantially to critical evaluation and presentation of scientific articles in the field of neurogenetics. IV) The students will have an understanding of the different genetic techniques and platforms available for studies in human (neurological) conditions.V) The students will have an insight in the application/use of genetic testing for neurological diseases. Kursens innehåll : I) The course will give examples of how different types of genetic studies can help us identify genes involced in the pathogenesis of neurological disease: i) Twinstudies, ii) population based studies, iii) casecontrol studies, iv) family studies. II) The course will give examples of different gene defects in neurological diseases such as trinucleotide repeats, point mutations, copy number variations, susceptibility genes, rearrangements, transciptional regulation and epigenetics. III) The course will provide an in depth understanding of the genetics of selected neurological diseases and how these genetic dysfunctions help us understand the molecular mechanisms of disease. Arbetsformer : Daily classroom lectures. The last session on Monday through Thursday will be in a workshop/seminar format where the students prepare a group presentation of a selected topic/genetic neurological disease. The presentation will be on the last day of the course and consitutes the examination. Examination : The examination will be on the last day of the course and it will consist of i) participating in a group presentation of a selected topic/genetic neurological disease ii) participate as an active audience when other groups have their presentations. Every student will be assessed individually in accordance with the intended learning outcomes of the course. Obligatoriska moment : All lectures/seminars are compulsory and in case of absence, the session can be compensated by a short written report using the literature after agreement with the course director. Antal studenter : 7 20 Urval av studenter : Selection will be based on 1) the applicant's written motivation 2) the date of admission to doctoral education. Övrig information : The course is part if the Frontiers Courses in Neuroscience and the course participants will be a mix of master students and PhDstudents. This is a fulltime course (9:0017:00) and will be held at the Karolinska Institutet. Details about specific lecturehalls and seminar rooms will be provided in August 2015. Kursansvarig : Caroline Graff Institutionen för neurobiologi, vårdvetenskap och samhälle 0858583619 [email protected] KIADRC, Novum plan 5 141 86 Stockholm Kontaktpersoner : Annica Rönnbäck Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Title : Brain development and Neurodevelopmental disorders Kursnummer : 2605 Antal högskolepoäng : 1.5 Datum : 20150921 20150925 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neuroscience Särskild behörighet : Background in medicine, biomedicine, neuroscience or psychology. Kursens lärandemål : The aim of this translational neuroscience course is to provide an overview on the emerging field of developmental cognitive neuroscience. In particular, we will focus on cortical brain development, development of cognitive functions in typically developing children and children with neurodevelopmental disorders e.g., AttentionDeficit /Hyperactivity Disorder (ADHD) and Autism Spectrum Disorders (ASD), and the role of both genetic and environmental factors in the etiology of these disorders. During the course, students will learn to critically evaluate and explain in presentations the content of original articles. After the course students should be able to: 1) Describe fundamental neurodevelopmental processes (e.g. neurogenesis, neuronal migration, synaptogenesis). 2) Describe genetic and molecular mechanisms controlling cortical development. 3) Describe cognitive deficits among neurodevelopmental disorders (e.g., ADHD and ASD). 4) Postulate potential genetic /molecular mechanisms underlying cognitive deficits in children with neurodevelopmental disorders Kursens innehåll : Course Curriculum Part I: Fundamentals of Developmental Neurobiology 1. Early brain development, construction of neural circuits, and modification of neural circuits as a result of experience 2. Genetic control of cortical development 3. Effects of sex hormones on brain development Part II: Functional Brain development in humans 1. AgeRelated Changes in executive function (e.g., working memory) 2. Working memory, and training induced plasticity 3. The molecular genetics of executive function Part III: Neurodevelopmental Aspects of Clinical Disorders 1. The neurobiology and genetics of ADHD 2. Advances in the Cognitive Neuroscience of ASD 3. Childhood psychiatric disorders as anomalies in neurodevelopmental trajectories Arbetsformer : A variety of teaching and learning strategies are presented during the course to facilitate students learning. These strategies include short lectures, small group discussions, computerbased learning, and problem based learning. Examination : The examination will consist of an oral group presentation focusing on cognitive deficits found in children with neurodevelopmental disorders (e.g. ADHD and ASD) and the potential genetic / molecular mechanisms underlying these deficits. At the beginning of the course, students will be assigned into different working group themes e.g., ADHD and ASD. These groups will work together throughout the course and prepare for the final oral presentation. During the course there will also be formative assessments to give students immediate feedback about their learning process during the different milestones of the course and clarify any questions relating to the final assessment. Course grades Pass: Students demonstrate an understanding of brain development and cognitive deficits found in neuro developmental disorders, and can postulate/hypothesize potential genetic / molecular mechanisms underlying these deficits based upon findings from both basic and clinical literature. Obligatoriska moment : All lectures and seminars are mandatory. In order to make up for absence of a particular lecture, the students will be required to read specific chapters from the recommended literature and write a short report. Antal studenter : 15 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : We are very honored to have Professor Pasko Rakic from Yale University School of Medicine as our keynote speaker and other top international speakers, including Professor Derrick MacFabe from the University of Western Ontario. The course will take place at KI Solna campus (Monday through Friday between 09:0016:30). Note: The title of the course will change to "Neurodevelopmental Disorders: From basic research to the clinic". Kursansvarig : Rochellys Heijtz Institutionen för neurovetenskap 0852487886 [email protected] Retzius Väg 8 17177 Stockholm Kontaktpersoner : Title : Mechanisms of Gene Regulation in Metabolism Kursnummer : 2608 Antal högskolepoäng : 1.5 Datum : 20151105 20151111 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Physiology and Pharmacology Särskild behörighet : Kursens lärandemål : At the end of the course students will understand and be able to discuss the different mechanisms that regulate gene expression. They will be able to describe how these processes can affect metabolic disease and disease progression. The students will be able to choose the most appropriate methodologies to study diverse aspects of gene regulation in metabolism. Kursens innehåll : This course aims at giving students an overview of the current understanding of how metabolism and metabolic dysfunction are controlled at the level of gene regulation. During one week, students will focus on the genetic and epigenetic mechanisms that affect transcriptional output in diverse organs and tissues in health and disease situations. This will include: basic mechanisms of gene transcription, transcription factors and coregulators, mRNA splicing and genetic variability, the chromatin landscape and associated DNA and histone modifications, noncoding RNAs and regulation of gene expression. Attention will be given to single gene analysis as well as global regulation of gene expression. In each module the student will be introduced to the basic concepts in the field and analyze situations in which dysregulation of the processes under examination leads to metabolic disease. Each module will include a chapter dedicated to the presentation and discussion of current experimental approaches relevant to research in that particular field of science. Arbetsformer : This course will consist mainly of lectures and group discussions covering both theoretical and practical questions related to the different areas of gene regulation and metabolism. Some sessions will be dedicated to problem solving and presentation of stateoftheart methodologies relevant to research in each field. Examination : Examination will consist of an oral presentation in which students discuss an example of metabolic disorder caused by dysregulation of gene expression and propose a research plan to further study that problem. The research plan should include appropriate methodology learned during the course. Obligatoriska moment : Presence at lectures, group work, and final presentation and discussion is mandatory. To compensate for absence a written essay on the missed topic must be performed. Antal studenter : 10 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course duration is 5 weekdays and it's divided in two blocks. The first block (Nov 5 6) addresses more general knowledge in mechanisms of gene regulation with focus on metabolism, and the second (Nov 9 11), the more specialised course content. We always have an invited lecturer who will be announced closer to the date since we are still awaiting confirmation. Kursansvarig : Jorge Ruas Institutionen för Fysiologi och Farmakologi (08)52487261 [email protected] von Eulers väg 8 17177 Stockholm Kontaktpersoner : Title : Basic Course in Medical Statistics a distance course Kursnummer : 2609 Antal högskolepoäng : 3.0 Datum : 20150921 20151002 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : The course participants shall after the course be able to perform basic summaries, analyses and presentation of data, as well as have enhanced their ability to recognise, understand and critically view the statistics being presented in medical articles. Kursens innehåll : The course is an introduction to basic statistical principles and how statistics play a part in medical research. Concepts being treated are hypothesis, type I error, type II error, estimates, measurement of dispersion, regression analysis, inference making and how to present the results. Arbetsformer : The course will be a distance course by using the platform edX. The course contains videolectures, exercises with suggested solutions and 2 statistical software demonstration videos Statistica and SPSS. The first and last day of the course will be facetoface with an introduction the first day and seminars and group discussions the last day. In addition to the different videomoments the time will be spent working on computer based exercises and reading the course literature. Examination : Course requirements: Correct answers on the computer based exercises. The doctoral student will during the seminars have to demonstrate their ability to recognise, understand and criticize the statistics presented in the medical articles by active participation in the discussions. Obligatoriska moment : Attendance is mandatory for the seminars on the last day of the course. If the student is absent, he or she can compensate the absence by handing in written answers to questions concerning the compulsory moments. Antal studenter : 40 50 Urval av studenter : Date for registration as a doctoral student (priority given to earlier registration date). Please make sure that you have entered the correct registration date for doctoral education in your personal profile. Övrig information : Kursansvarig : Mesfin Tessma Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Margareta KrookBrandt Institutionen för lärande, informatik, management och etik 52487118 Margareta.Krook[email protected] Title : Frontiers in Cogntive Neuroscience Kursnummer : 2616 Antal högskolepoäng : 1.5 Datum : 20150914 20150918 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neuroscience Särskild behörighet : 180 hp in medicine, biomedicine, biology, psychology, or cognitive science, or master degree in medical imaging engineering Kursens lärandemål : After the course the student must be able to: (1) account for current concepts and key principles of cognitive neuroscience; (2) show an understanding of the interdisiplinary nature of cognitive neuroscience with its roots in both psychology and neuroscience; (3) discuss and critically evaluate scientific articles in the field; (4) To show basic knowledge about the strengths and weakness of the different stateoftheart methods used in cognitive neuroscience. Kursens innehåll : (1) Series of lectures informing about the state of art knowledge about: (i) Perception and sensory mechanisms; (ii) action planning and execution (iii); (iv) sex differences in the brain; (v) higher cognitive functions including working memory and creativity; (vi) memory; and (vii) cognitive effects of aging (2) Seminars where the students will critically discuss key published papers, and group presentations where they will present their analyses and conclusions for the whole group. Arbetsformer : Lectures, seminars, and group presentations. Examination : The oral presentation and group discussions during the last day¿s seminar count as examination. We will assess individual students¿ ability to discuss and reason about current issues and problems in cognitive neuroscience. Obligatoriska moment : The group seminar is obligatory. In addition to that, the students are assumed to take part in the lectures. The student will be able to compensate missing attendance by submitting written reports on the missed material later. Antal studenter : 12 30 Urval av studenter : Selection will be based on 1) having signed up for the doctoral programme in Neuroscience or similar field, 2) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 3) date for registration as a doctoral student (priority given to earlier registration date)<br> For more information about the doctoral programmes at KI, see: https://internwebben.ki.se/en/doctoralprogrammes0 Övrig information : Full day course, Monday to Friday. Kursansvarig : Henrik Ehrsson Institutionen för neurovetenskap 0852487231 [email protected] Retzius väg 8 17177 Stockholm Kontaktpersoner : Title : Write your research results and get them published Kursnummer : 2618 Antal högskolepoäng : 3.0 Datum : 20151012 20151023 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Women's and children's health Särskild behörighet : None. Kursens lärandemål : AFTER ATTENDING THE COURSE, THE PhD STUDENT SHOULD BE ABLE TO: Explain the characteristics and disposition of different written presentation media and decide which forum is the most suitable for a specific text Understand, and apply, the terminology associated with scientific writing Write an abstract Use the correct structure and language to compose a scientific paper and follow the editorial requirements Revise a manuscript according to a checklist with the most common lanuage and structure mistakes in scientific writing Use the focus points in a scientific paper (where the readers focus their reading) Identify the main scope and focus of the research and summarize information aligned to the target group Apply the structure of popular science writing and use popular science as a tool for presentations Give a poster presentation Design a scientific poster and reflect upon structure, language and style Understand the ethics in publication Use the software EndNote for reference management Search for references in databases (e.g. PubMed) and decide what sources are reliable Respond to the reviewer´s comments Write a cover letter Reflect on his/her own development as a writer of different texts during the course Kursens innehåll : THE MAIN SCOPE OF THE COURSE is how to write about research in different contexts and forums. THE CONTENT OF THE COURSE: Terminology associated to scientific writing Designing and writing a poster an abstract a draft for a research paper a project plan a reply to the reviewer´s comments a cover letter a popular science paper The writing process: structure, language, style Editorial requirements of different journals Summarising and presenting information aiming at the target audience Identifying the main scope of a research project References and reference management (EndNote software) Data base search Basic rhetoric for poster presentations References Ethics in publication Arbetsformer : Lectures, seminares, writing exercises, group assignments and practical exercises. As part of the learning process, the Ph.D students will be members of inclass review groups, giving feedback to their colleagues. Examination : 1) Written assignments reflecting the learning goals of the course: draft for scientific and popular science paper, poster, electronic poster, and abstract. 2) Evaluation sessions, where the PhD students give each other feed back on the written assignments as a part of the learning process 3) Poster presentation, where the PhD students present their posters to another course participant (there are no presentations in front of a larger group) Obligatoriska moment : Lectures, workshops, evaluation sessions, and group assignments as well as all written assignments. Absence can be compensated: a) during next years course b) individual assigments Antal studenter : 18 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to LATER registration date) Övrig information : Welcome to apply for the Ph. D. writing course 2618 on Scientific and popular science writing! <p> During the course, you will have the opportunity to write a draft for a scientific manuscript, an abstract, a popular science article, a press release, and to design a poster. The popular science writing is used as a tool for finding the core of your research project, poster design and presentations. <p> The course also covers: presentation techniques for presenting your poster at a conference, how to answer the reviewer's questions, letter to the editor, review article, cover letter, and ethics in publication. New Ph.D. students are given priority to the course, as we believe that writing is an essential skill that should be acquired as soon as possible during your time as a doctoral student. However, students who have already published articles will benefit as much from the course as newly registered students, as you write about your own research projects, starting on your own level, and in your own pace. The course curriculum takes into consideration that all students have different background knowledge and are on different stages of their doctoral education. In order to participate in the course, you need either some preliminary data from your own research project or other data provided by your supervisor to work with. Our intention is that you should be able to use everything you write and design during the course: this will keep motivation high and make sure that you are spending your time in the best possible way. <p> Please address all questions to Anna Hildenbrand Wachtmeister: [email protected] Cellphone: 0707890607 <p> We are looking forward to meeting you in the course! Kursansvarig : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Kontaktpersoner : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Lalit Kumar Institutionen för kvinnors och barns hälsa [email protected] Title : Write your research results and get them published Kursnummer : 2618 Antal högskolepoäng : 3.0 Datum : 20150928 20151009 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Women's and children's health Särskild behörighet : None. Kursens lärandemål : AFTER ATTENDING THE COURSE, THE PhD STUDENT SHOULD BE ABLE TO: Explain the characteristics and disposition of different written presentation media and decide which forum is the most suitable for a specific text Understand, and apply, the terminology associated with scientific writing Write an abstract Use the correct structure and language to compose a scientific paper and follow the editorial requirements Revise a manuscript according to a checklist with the most common lanuage and structure mistakes in scientific writing Use the focus points in a scientific paper (where the readers focus their reading) Identify the main scope and focus of the research and summarize information aligned to the target group Apply the structure of popular science writing and use popular science as a tool for presentations Give a poster presentation Design a scientific poster and reflect upon structure, language and style Understand the ethics in publication Use the software EndNote for reference management Search for references in databases (e.g. PubMed) and decide what sources are reliable Respond to the reviewer´s comments Write a cover letter Reflect on his/her own development as a writer of different texts during the course Kursens innehåll : THE MAIN SCOPE OF THE COURSE is how to write about research in different contexts and forums. THE CONTENT OF THE COURSE: Terminology associated to scientific writing Designing and writing a poster an abstract a draft for a research paper a project plan a reply to the reviewer´s comments a cover letter a popular science paper The writing process: structure, language, style Editorial requirements of different journals Summarising and presenting information aiming at the target audience Identifying the main scope of a research project References and reference management (EndNote software) Data base search Basic rhetoric for poster presentations References Ethics in publication Arbetsformer : Lectures, seminares, writing exercises, group assignments and practical exercises. As part of the learning process, the Ph.D students will be members of inclass review groups, giving feedback to their colleagues. Examination : 1) Written assignments reflecting the learning goals of the course: draft for scientific and popular science paper, poster, electronic poster, and abstract. 2) Evaluation sessions, where the PhD students give each other feed back on the written assignments as a part of the learning process 3) Poster presentation, where the PhD students present their posters to another course participant (there are no presentations in front of a larger group) Obligatoriska moment : Lectures, workshops, evaluation sessions, and group assignments as well as all written assignments. Absence can be compensated: a) during next years course b) individual assigments Antal studenter : 18 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to LATER registration date) Övrig information : Welcome to apply for the Ph. D. writing course 2618 on Scientific and popular science writing! <p> During the course, you will have the opportunity to write a draft for a scientific manuscript, an abstract, a popular science article, a press release, and to design a poster. The popular science writing is used as a tool for finding the core of your research project, poster design and presentations. <p> The course also covers: presentation techniques for presenting your poster at a conference, how to answer the reviewer's questions, letter to the editor, review article, cover letter, and ethics in publication. New Ph.D. students are given priority to the course, as we believe that writing is an essential skill that should be acquired as soon as possible during your time as a doctoral student. However, students who have already published articles will benefit as much from the course as newly registered students, as you write about your own research projects, starting on your own level, and in your own pace. The course curriculum takes into consideration that all students have different background knowledge and are on different stages of their doctoral education. In order to participate in the course, you need either some preliminary data from your own research project or other data provided by your supervisor to work with. Our intention is that you should be able to use everything you write and design during the course: this will keep motivation high and make sure that you are spending your time in the best possible way. <p> Please address all questions to Anna Hildenbrand Wachtmeister: [email protected] Cellphone: 0707890607 <p> We are looking forward to meeting you in the course! Kursansvarig : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Kontaktpersoner : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Lalit Kumar Institutionen för kvinnors och barns hälsa [email protected] Title : Write your research results and get them published Kursnummer : 2618 Antal högskolepoäng : 3.0 Datum : 20151116 20151127 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Women's and children's health Särskild behörighet : None. Kursens lärandemål : AFTER ATTENDING THE COURSE, THE PhD STUDENT SHOULD BE ABLE TO: Explain the characteristics and disposition of different written presentation media and decide which forum is the most suitable for a specific text Understand, and apply, the terminology associated with scientific writing Write an abstract Use the correct structure and language to compose a scientific paper and follow the editorial requirements Revise a manuscript according to a checklist with the most common lanuage and structure mistakes in scientific writing Use the focus points in a scientific paper (where the readers focus their reading) Identify the main scope and focus of the research and summarize information aligned to the target group Apply the structure of popular science writing and use popular science as a tool for presentations Give a poster presentation Design a scientific poster and reflect upon structure, language and style Understand the ethics in publication Use the software EndNote for reference management Search for references in databases (e.g. PubMed) and decide what sources are reliable Respond to the reviewer´s comments Write a cover letter Reflect on his/her own development as a writer of different texts during the course Kursens innehåll : THE MAIN SCOPE OF THE COURSE is how to write about research in different contexts and forums. THE CONTENT OF THE COURSE: Terminology associated to scientific writing Designing and writing a poster an abstract a draft for a research paper a project plan a reply to the reviewer´s comments a cover letter a popular science paper The writing process: structure, language, style Editorial requirements of different journals Summarising and presenting information aiming at the target audience Identifying the main scope of a research project References and reference management (EndNote software) Data base search Basic rhetoric for poster presentations References Ethics in publication Arbetsformer : Lectures, seminares, writing exercises, group assignments and practical exercises. As part of the learning process, the Ph.D students will be members of inclass review groups, giving feedback to their colleagues. Examination : 1) Written assignments reflecting the learning goals of the course: draft for scientific and popular science paper, poster, electronic poster, and abstract. 2) Evaluation sessions, where the PhD students give each other feed back on the written assignments as a part of the learning process 3) Poster presentation, where the PhD students present their posters to another course participant (there are no presentations in front of a larger group) Obligatoriska moment : Lectures, workshops, evaluation sessions, and group assignments as well as all written assignments. Absence can be compensated: a) during next years course b) individual assigments Antal studenter : 18 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to LATER registration date) Övrig information : Welcome to apply for the Ph. D. writing course 2618 on Scientific and popular science writing! <p> During the course, you will have the opportunity to write a draft for a scientific manuscript, an abstract, a popular science article, a press release, and to design a poster. The popular science writing is used as a tool for finding the core of your research project, poster design and presentations. <p> The course also covers: presentation techniques for presenting your poster at a conference, how to answer the reviewer's questions, letter to the editor, review article, cover letter, and ethics in publication. New Ph.D. students are given priority to the course, as we believe that writing is an essential skill that should be acquired as soon as possible during your time as a doctoral student. However, students who have already published articles will benefit as much from the course as newly registered students, as you write about your own research projects, starting on your own level, and in your own pace. The course curriculum takes into consideration that all students have different background knowledge and are on different stages of their doctoral education. In order to participate in the course, you need either some preliminary data from your own research project or other data provided by your supervisor to work with. Our intention is that you should be able to use everything you write and design during the course: this will keep motivation high and make sure that you are spending your time in the best possible way. <p> Please address all questions to Anna Hildenbrand Wachtmeister: [email protected] Cellphone: 0707890607 <p> We are looking forward to meeting you in the course! Kursansvarig : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Kontaktpersoner : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Lalit Kumar Institutionen för kvinnors och barns hälsa [email protected] Title : Write your research results and get them published Kursnummer : 2618 Antal högskolepoäng : 3.0 Datum : 20150907 20150918 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Women's and children's health Särskild behörighet : None. Kursens lärandemål : AFTER ATTENDING THE COURSE, THE PhD STUDENT SHOULD BE ABLE TO: Explain the characteristics and disposition of different written presentation media and decide which forum is the most suitable for a specific text Understand, and apply, the terminology associated with scientific writing Write an abstract Use the correct structure and language to compose a scientific paper and follow the editorial requirements Revise a manuscript according to a checklist with the most common lanuage and structure mistakes in scientific writing Use the focus points in a scientific paper (where the readers focus their reading) Identify the main scope and focus of the research and summarize information aligned to the target group Apply the structure of popular science writing and use popular science as a tool for presentations Give a poster presentation Design a scientific poster and reflect upon structure, language and style Understand the ethics in publication Use the software EndNote for reference management Search for references in databases (e.g. PubMed) and decide what sources are reliable Respond to the reviewer´s comments Write a cover letter Reflect on his/her own development as a writer of different texts during the course Kursens innehåll : THE MAIN SCOPE OF THE COURSE is how to write about research in different contexts and forums. THE CONTENT OF THE COURSE: Terminology associated to scientific writing Designing and writing a poster an abstract a draft for a research paper a project plan a reply to the reviewer´s comments a cover letter a popular science paper The writing process: structure, language, style Editorial requirements of different journals Summarising and presenting information aiming at the target audience Identifying the main scope of a research project References and reference management (EndNote software) Data base search Basic rhetoric for poster presentations References Ethics in publication Arbetsformer : Lectures, seminares, writing exercises, group assignments and practical exercises. As part of the learning process, the Ph.D students will be members of inclass review groups, giving feedback to their colleagues. Examination : 1) Written assignments reflecting the learning goals of the course: draft for scientific and popular science paper, poster, electronic poster, and abstract. 2) Evaluation sessions, where the PhD students give each other feed back on the written assignments as a part of the learning process 3) Poster presentation, where the PhD students present their posters to another course participant (there are no presentations in front of a larger group) Obligatoriska moment : Lectures, workshops, evaluation sessions, and group assignments as well as all written assignments. Absence can be compensated: a) during next years course b) individual assigments Antal studenter : 18 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to LATER registration date) Övrig information : Welcome to apply for the Ph. D. writing course 2618 on Scientific and popular science writing! <p> During the course, you will have the opportunity to write a draft for a scientific manuscript, an abstract, a popular science article, a press release, and to design a poster. The popular science writing is used as a tool for finding the core of your research project, poster design and presentations. <p> The course also covers: presentation techniques for presenting your poster at a conference, how to answer the reviewer's questions, letter to the editor, review article, cover letter, and ethics in publication. New Ph.D. students are given priority to the course, as we believe that writing is an essential skill that should be acquired as soon as possible during your time as a doctoral student. However, students who have already published articles will benefit as much from the course as newly registered students, as you write about your own research projects, starting on your own level, and in your own pace. The course curriculum takes into consideration that all students have different background knowledge and are on different stages of their doctoral education. In order to participate in the course, you need either some preliminary data from your own research project or other data provided by your supervisor to work with. Our intention is that you should be able to use everything you write and design during the course: this will keep motivation high and make sure that you are spending your time in the best possible way. <p> Please address all questions to Anna Hildenbrand Wachtmeister: [email protected] Cellphone: 0707890607 <p> We are looking forward to meeting you in the course! Kursansvarig : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Kontaktpersoner : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Lalit Kumar Institutionen för kvinnors och barns hälsa [email protected] Title : Write your research results and get them published Kursnummer : 2618 Antal högskolepoäng : 3.0 Datum : 20151130 20151211 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Women's and children's health Särskild behörighet : None. Kursens lärandemål : AFTER ATTENDING THE COURSE, THE PhD STUDENT SHOULD BE ABLE TO: Explain the characteristics and disposition of different written presentation media and decide which forum is the most suitable for a specific text Understand, and apply, the terminology associated with scientific writing Write an abstract Use the correct structure and language to compose a scientific paper and follow the editorial requirements Revise a manuscript according to a checklist with the most common lanuage and structure mistakes in scientific writing Use the focus points in a scientific paper (where the readers focus their reading) Identify the main scope and focus of the research and summarize information aligned to the target group Apply the structure of popular science writing and use popular science as a tool for presentations Give a poster presentation Design a scientific poster and reflect upon structure, language and style Understand the ethics in publication Use the software EndNote for reference management Search for references in databases (e.g. PubMed) and decide what sources are reliable Respond to the reviewer´s comments Write a cover letter Reflect on his/her own development as a writer of different texts during the course Kursens innehåll : THE MAIN SCOPE OF THE COURSE is how to write about research in different contexts and forums. THE CONTENT OF THE COURSE: Terminology associated to scientific writing Designing and writing a poster an abstract a draft for a research paper a project plan a reply to the reviewer´s comments a cover letter a popular science paper The writing process: structure, language, style Editorial requirements of different journals Summarising and presenting information aiming at the target audience Identifying the main scope of a research project References and reference management (EndNote software) Data base search Basic rhetoric for poster presentations References Ethics in publication Arbetsformer : Lectures, seminares, writing exercises, group assignments and practical exercises. As part of the learning process, the Ph.D students will be members of inclass review groups, giving feedback to their colleagues. Examination : 1) Written assignments reflecting the learning goals of the course: draft for scientific and popular science paper, poster, electronic poster, and abstract. 2) Evaluation sessions, where the PhD students give each other feed back on the written assignments as a part of the learning process 3) Poster presentation, where the PhD students present their posters to another course participant (there are no presentations in front of a larger group) Obligatoriska moment : Lectures, workshops, evaluation sessions, and group assignments as well as all written assignments. Absence can be compensated: a) during next years course b) individual assigments Antal studenter : 18 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to LATER registration date) Övrig information : Welcome to apply for the Ph. D. writing course 2618 on Scientific and popular science writing! <p> During the course, you will have the opportunity to write a draft for a scientific manuscript, an abstract, a popular science article, a press release, and to design a poster. The popular science writing is used as a tool for finding the core of your research project, poster design and presentations. <p> The course also covers: presentation techniques for presenting your poster at a conference, how to answer the reviewer's questions, letter to the editor, review article, cover letter, and ethics in publication. New Ph.D. students are given priority to the course, as we believe that writing is an essential skill that should be acquired as soon as possible during your time as a doctoral student. However, students who have already published articles will benefit as much from the course as newly registered students, as you write about your own research projects, starting on your own level, and in your own pace. The course curriculum takes into consideration that all students have different background knowledge and are on different stages of their doctoral education. In order to participate in the course, you need either some preliminary data from your own research project or other data provided by your supervisor to work with. Our intention is that you should be able to use everything you write and design during the course: this will keep motivation high and make sure that you are spending your time in the best possible way. <p> Please address all questions to Anna Hildenbrand Wachtmeister: [email protected] Cellphone: 0707890607 <p> We are looking forward to meeting you in the course! Kursansvarig : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Kontaktpersoner : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Lalit Kumar Institutionen för kvinnors och barns hälsa [email protected] Title : Brain circuits Kursnummer : 2624 Antal högskolepoäng : 1.5 Datum : 20150907 20150911 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neuroscience Särskild behörighet : Kursens lärandemål : By the end of the course the student shall be able to: Explain the structure and function of main neuronal circuits in the brain. Describe the principles for excitatory and inhibitory networks, including receptors and neurotransmittors, as well as the action of different chemical neuromodulators. Describe principles, use and readout of optogenetics and recording technologies. Describe principles of viral labeling and tracing of neuronal circuits. Explain how dysfunctions of networks can manifest as neuropsychiatric disorders. Describe animal behavior tests probing specific networks and network functions. Kursens innehåll : The course will cover the organization and function of main circuits in the brain, including the interaction and participation of different cell types, the interplay between excitation and inhibition, and how circuit output result in behavior. Different techniques for labeling and manipulation of neuronal circuits will be discussed, including molecular targeting, optogenetics and transsynaptic viral tracing. The connection between deficient circuit functions and neuropsychiatric disorder will be included, as well as animal behavior tests probing specific circuits and circuit (dys)functions. Specific emphasis will be put into describing the technologies currently used in the neuroscience field. Arbetsformer : Lectures by invited experts and group exercises. Examination : The student should in discussions and a seminar presentation demonstrate the ability to critically evaluate original research papers on the topics covered and be able to show that the intended learning outcomes for the course are reached. Obligatoriska moment : The seminar presentations are obligatory. Antal studenter : 16 28 Urval av studenter : We welcome highly motivated applicants from all areas of neuroscience. Basic knowledge of how neurons function and of brain anatomy is a prerequisite to benefit from the course. Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project according to the written motivation in the application, 2) date for registration as a PhD student (priority given to earlier reg. date), 3) Experience of neuroscience research as stated in the written motivation. Övrig information : The course will be given in lecture hall Tellus, Department of Neuroscience, Scheeles väg 1, Karolinska Institutet, Solna. Time: 9.0017.00 Monday to Friday. Invited teachers are international scientists with important contributions to and expertise in their respective fields, often involving development or application of novel technologies. Confirmed speakers: Karl Deisseroth Stanford University, Peter Magill University of Oxford, Daniel Huber University of Geneva, Menno Witter NTNU Trondheim, Laura Busse University of Tubingen, Ofer Yizhar Wiezmann Institute of Science, Jeremiah Cohen Johns Hopkins, Konstantinos Meletis, Marie Carlén and Gilad Silberberg Karolinska Institutet, and more. Kursansvarig : Marie Carlen Institutionen för neurovetenskap 0852483043 [email protected] Kontaktpersoner : Title : Neurodegenerative disorders I From molecule to treatment Kursnummer : 2629 Antal högskolepoäng : 1.5 Datum : 20151005 20151009 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Kursens lärandemål : The student should after the course: 1) understand cellular processes and molecular mechanisms of neurodegeneration 2) understand mechanisms of protein turnover, degradation and aggregation 3) based on knowledge of these mechanisms critically be able to evaluate the concept of conformational disorders and its relevance to the different neurodegenerative disorders 4) have achieved basic knowledge about epidemiology, symptoms, pathology and current treatments of the most common neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis and multiple sclerosis. 5) In addition, the student should understand how the pathology of these disorders is reflected in their symptoms. 6) Based on this understanding, the student should be able to discuss the effects of treatments, if they are (or may be) symptomatic or curative. 7) Be able to evaluate the relevance of different disease models, their advantages and limitations with respect to the clinical picture and to what is known about disease mechanisms. Kursens innehåll : The course will cover topics related to the degeneration of neural cells, apoptosis and necrosis as well as the cellular and biochemical reactions to neuronal injury. During the course we will also present and discuss symptoms, diagnosis, pathology, epidemiology, genetics and treatment of the most common neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis and multiple sclerosis. Molecular mechanisms of current and future treatment strategies, disease models and their potential will be presented and discussed. In addition, the students may within group assignments study less common neurodegenerative diseases such as frontotemporal dementia, Lewy body disease, ataxias, prion diseases as well as vascular, inflammatory or trauma related causes of neurodegeneration such as stroke, epilepsy or trauma. Arbetsformer : The course runs day time for 1 week fulltime with lectures by invited scientists, literature seminars as group assignments, and individual studies. Examination : The examination part includes: the group assignments, the oral presentations by the students and the following general discussion between all participants. All students are individually assessed. Obligatoriska moment : The group assignments, the oral presentations by the students and the following general discussion between all participants are compulsory. Students that are absent from these parts will have to individually submit a written presentation of the subject. Antal studenter : 10 30 Urval av studenter : If selection of course participants is necessary, we will prioritize 1) students for whom the course is mandatory, 2) students with an educational plan encompassing the topics of the course, and 3) students close to thesis defence missing course on the topic. Övrig information : The course will be held at Karolinska Institutet, Huddinge. Kursansvarig : Elisabet Åkesson Institutionen för neurobiologi, vårdvetenskap och samhälle 08585 838 92 [email protected] Kontaktpersoner : Helena Karlström Institutionen för neurobiologi, vårdvetenskap och samhälle 08585 837 77 [email protected] Maria Roos Institutionen för neurobiologi, vårdvetenskap och samhälle 0858585417 [email protected] Title : Neurodegenerative disorders II cellular and molecular mechanisms Kursnummer : 2630 Antal högskolepoäng : 1.5 Datum : 20151012 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Kursens lärandemål : The student should: Understand and critically evaluate relevant cellular and molecular pathophysiological mechanisms of neurodegenerative disorders such as stroke, Alzheimer¿s disease, frontotemporal dementia, Lewy body disease, Parkinson¿s disease, multiple sclerosis, amyotrophic lateral sclerosis, ataxias, prion diseases, epilepsy and trauma, and the mechanisms of current and/or possible future treatments. Understand and be able to perform the common assays of cell degeneration, and discuss the results, taking into account the limitations of the assays. Be able to discuss the present disease models, propose alternative models, and critically evaluate these models from the perspectives of a) clinical picture, b) disease mechanisms, and c) treatment mechanisms. Kursens innehåll : The course is a continuation of the course Neurodegenerative disorders ¿ From molecule to treatment, but it can also be taken as a separate course, provided the participant has in other ways achieved the learning outcomes of that course. The course addresses topics in basic and clinical research on neurodegenerative disorders, with a particular focus on the cellular and molecular mechanisms. The focus will be on a deeper understanding of cellular and molecular mechanisms, and the techniques to study them. Arbetsformer : The course runs daytime for 1 week fulltime with some key lectures by invited scientists, laboratory practicals, literature seminars, and discussions in small groups and the entire class. Examination : Written examination followed by group discussions on the examination questions, and a general discussion between all participants. Obligatoriska moment : Laboratory practicals, literature seminars and the exam (including the group discussion after the exam) are compulsory. Students that are absent from literature seminars and/or practicals will have to submit a written presentation of the subject. Antal studenter : 12 24 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Lars Tjernberg Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Kontaktpersoner : Sophia Schedin Weiss Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Title : Human physiology an overview Kursnummer : 2644 Antal högskolepoäng : 3.0 Datum : 20150914 20150925 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Physiology and Pharmacology Särskild behörighet : Kursens lärandemål : The student will after completed course have an overview and understanding of how the organ systems of the human body function and interact under normal conditions. The course content will also be possible to use for further studies in a PhD education where knowledge about human biology is of value. More specifically, the student will be able to: Demonstrate knowledge about basic functions of and interaction between organ systems. Assemble and share information in selected areas. Demonstrate a critical and scientific attitude to literature sources for the different course tasks. Kursens innehåll : Overview of cellular and integrative physiology Basic anatomy and biochemistry Physiology of the nervous system Endocrinology Digestion physiology Cardiovascular physiology Renal physiology, fluid balance, acidbase balance Respiration Arbetsformer : Different learning forms such as problem based learning, lectures and a handson human lab session. Full time during two consecutive weeks. Examination : To pass the course, the student has to show that the learning outcomes have been achieved. Assessment methods used are an oral quiz along with a written exam. Obligatoriska moment : The examination tasks and the handson human lab are compulsory. Students that are absent from the oral quiz or the handson lab will have to compensate it in agreement with the course organizer. Students that are absent from the exam or do not obtain a passing grade in the first examination will be offered a second examination. Antal studenter : 10 30 Urval av studenter : Selection is based on 1) the date of admission to doctoral education 2) the relevance of the syllabus to the doctoral projects of the applicants. Övrig information : Lectures will take place in mornings and afternoons. Most of the lectures will take place at von Eulers väg 4a/b, KI Solna. � Among the lecturers are Carl Johan Sundberg and Jessica Norrbom. Kursansvarig : Jessica Norrbom Institutionen för Fysiologi och Farmakologi [email protected] Kontaktpersoner : Charlotte Schönbeck Institutionen för Fysiologi och Farmakologi [email protected] Title : Människans fysiologi en översikt Kursnummer : 2644 Antal högskolepoäng : 3.0 Datum : 20150907 20150918 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Physiology and Pharmacology Särskild behörighet : Kursens lärandemål : Studenten ska efter genomgången kurs ha översiktlig kunskap och förståelse för hur människokroppens organsystem fungerar och samverkar under normala betingelser. Kursinnehållet ska kunna användas för fortsatt fördjupning inom en forskarutbildning där vissa humanbiologiska kunskaper är av värde. Färdigheter Muntligt kunna redogöra för organsystemens funktion. Sammanställa och delge information muntligt och skriftligt för utvalda fördjupningsområden. Förhållningssätt och värderingsförmåga Uppvisa ett kritiskt och vetenskapligt förhållningssätt till litteratur som inhämtas för olika fördjupningsuppgifter. Kursens innehåll : Översikt av cellulär och integrativ fysiologi Basal anatomi och biokemi Nervsystemets fysiologi Endokrinologi Digestionsfysiologi Hjärt cirkulationsfysiologi Njurfysiologi, vätskebalans, syrabasfysiologi Respiration Arbetsformer : Kursen innehåller delvis problembaserad undervisning, föreläsningar och en praktisk laboration. Examination : För att bli godkänd i kursen måste studenten visa att lärandemålen har uppnåtts. Detta bedöms genom en muntlig dugga och en skriftlig tentamen. Obligatoriska moment : Moment som är obligatoriska är examinationsuppgifter och praktisk laboration. Vid eventuell frånvaro vid muntlig dugga eller laboration kompenseras detta i överenskommelse med kursens koordinator. I anslutning till kursen ges ett resttentamenstillfälle. Antal studenter : 10 20 Urval av studenter : Urval sker utifrån 1) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) 2) utifrån kursplanens relevans för sökandes doktorandprojekt (enligt motivering). Övrig information : Föreläsningar är fördelade under förmiddag och eftermiddag och äger rum vid KI Campus, Solna. Doktorander har en del gemensamma föreläsningar med kursdeltagare från den fristående kursen Människans Fysiologi. Bland föreläsarna finns bland annat Håkan Westerblad och Carl Johan Sundberg. Kursansvarig : Carl J Sundberg Institutionen för Fysiologi och Farmakologi 0852486886 [email protected] von Eulers väg 8 17177 Stockholm Kontaktpersoner : Charlotte Schönbeck Institutionen för Fysiologi och Farmakologi [email protected] Title : Surgical Techniques in Rat and Mouse Kursnummer : 2647 Antal högskolepoäng : 2.0 Datum : 20150921 20150925 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Comparative medicine Särskild behörighet : Passed both Laboratory Animal Science for Researchers Rodents and Lagomorphs AND Laboratory Animal Science for Project Directors, OR have a FELASA C certificate. Kursens lärandemål : After the course the participants are expected to be able to: 1. handle pre, peri and postoperative care of rats and mice, including asepsis and analgesia 2. recognize microsurgery instruments and their use 3. set and use a microsurgery microscope 4. use appropriate suture materials 5. catheterize blood vessels and to collect blood Kursens innehåll : Analgesia and perioperative care, aseptic surgical techniques, basic surgical techniques including instrumentation, suturing and tissue handling, vein and artery cannulation, explorative laparotomy and blood sampling techniques. Rat will be our main animal model during the course (as techniques are easier to learn in a larger model), but mouse will also be available. Arbetsformer : A minor part of the learning activities are lectures (10%). The laboratory activities account for 70 % of the course. The remaining part of learning activities are demonstrations and project work (tutoring available). Examination : Assessment of learning outcomes To satisfactorily complete this course the participant must: 1) be able to perform a jugular vein cannulation and to perform blood sampling techniques 2) write a report of provided fictive research projects or of participant's own research project Obligatoriska moment : The presence of participants is required during all scheduled moments. Absence to lectures can be compensated by a written task. The laboratory moments are compulsory. A retake might be offered at the next course. Antal studenter : 10 16 Urval av studenter : The course offers very few places and only applications from PhD students registered at Karolinska Institutet will be considered. The relevance of microsurgery to the applicants research project, will also be considered. Övrig information : The course will take place at Comparative Medicine Learning Lab in Solna. Professor René Remie from the Netherlands and Professor Michael Axelsson from Gothenburg University, both experts on microsurgery techniques in rodents, are the course leaders. The course is to 95% practical. One week full time labs. Kursansvarig : Dude Gigliotti Komparativ medicin 0852486529 [email protected] von Eulers väg 4a, plan 4 171 77 STOCKHOLM Kontaktpersoner : Title : Mesenchymal stem cells biology and clinical potential. Kursnummer : 2652 Antal högskolepoäng : 2.0 Datum : 20151012 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department for Clinical Science, Intervention and Technology Särskild behörighet : None. Kursens lärandemål : After the completed course, the student will be able to describe the basics of stem cell biology and transplantation and a number of novel technologies and approaches in mesenchymal stem cell research and regenerative medicine. The student can demonstrate an interdisciplinary understanding of central concepts in mesenchymal stem cell science and critically evaluate different methods and techniques used. The student will be able to extract and integrate information from stateoftheart lectures in combination with overview articles and literature searches on the internet within the research field. Kursens innehåll : The course covers key concepts in translational research on mesenchymal stem cells from the laboratory to the patient in the clinic. This includes a general overview of stem cell biology, transplantation immunology, mesenchymal stem cell history, sources, homing and circulation and interaction with the immune system. Experts will give an advanced summary of the latest events in the mesenchymal stem cell field. The student will be required to take an active part, contribute and value discussions on ethical dilemmas in the transplantation area and in workshops on relevant topics in the mesenchymal stem cellfield. Networking with students and speakers is highly encouraged in this course. Arbetsformer : The pedagogic framing of this course is based on lectures with corresponding review papers. The course includes workshops with illustrative predicaments where the students are required to take an active part in the discussions. Group discussions and workshops will be conducted where the students discuss and integrate information from the lectures and review papers. The students prepare and present their examination task in a written report that is handed in after the course. Examination : Individual written project report that will be performed and handed in at the end of the course. The individual performance of each student will be evaluated separately. Obligatoriska moment : The lectures, workshops and discussions are mandatory. Compensation according to the instructions of the course director. Antal studenter : 10 30 Urval av studenter : The selection process will be based on a comprehensive assessment of the students: 1. Motivation for the course 2. Topic of their PhD project 3. Years since PhD registration Övrig information : The course is coorganised with the Swedish network for Mesenchymal stem cell biology and is given at Karolinska Institutet in Huddinge. Invited international key experts in the mesenchymal stem cell field will lecture at the course. The examination task (written report) will be handed in after the end of the course. Kursansvarig : Katarina Le Blanc Institutionen för laboratoriemedicin [email protected] Kontaktpersoner : Title : Grounded Theory in Health Research Kursnummer : 2654 Antal högskolepoäng : 3.0 Datum : 20151130 20151211 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Clinical Science and Education, Södersjukhuset Särskild behörighet : Kursens lärandemål : At the end of the course the participants should: 1. Be able to describe the experience of a classroom climate that incorporates principles of respect, mutuality, cooperation, collaboration, and teamwork. 2. Be able to demonstrate understanding of philosophical and practical underpinnings of grounded theory. 3. Be able to express understanding of the essential characteristics of grounded theory and exploration methodology. 4. Be able to apply knowledge of grounded theory in discussing rationales for design of grounded theory study. 5. Be able to understand and assess the applicability of a grounded theory methodology for a particular research problem. 6. Be able to critically comment/evaluate strength and weakness of studies(published papers) using grounded theory methodology 7. Be able to implicate grounded theory research findings for practice and future research 8. Be able to design grounded theory research proposals including: Title, Background, Research question, Study goal and objectives, Methodology and reasons to choose grounded theory methodology, Study population, Study sample (participants), Sampling method, Sample size, Inclusion and exclusion criteria, Data gathering technique/s, Data analysis method, Limitation, Ethical consideration, Trustworthiness/ Credibility(validity& reliability) Kursens innehåll : The course will provide practical, handson experience in using grounded theory research. Students will gain a knowledge and understanding of main features and the basic characteristics of grounded theory, the applicability of grounded theory for particular research problems, including those of their own original grounded theory research projects; and how to critically appraise appropriateness of grounded theory. The teachers will share their experience of grounded theory research method, the application of grounded theory in their respective fields and provide advice and consultation on the advanced use of cuttingedge grounded theory. The course will start with a deep discussion about what grounded theory is, the aim of grounded theory and when to use grounded theory. Then teachers will continue with key characteristics of grounded theory research, the applicability of grounded theory for particular research problems, how to conduct a grounded theory study; and evaluation of rigor in this approach. Students will learn to evaluate and make comments on published grounded theory studies in terms of methodology, data gathering, quality of gathered data, data analysis approach, display of result, study limitation and ethical considerations. Finally implications of grounded theory findings for practice and future research will be discussed and students will learn to design a grounded theory research proposal in their respective fields. Arbetsformer : The learning activities of the course are a mix of lectures, discussions, individual and group activities; interviews, seminars, field observations and individual and group presentations. Examination : The course assessment will include formative and summative assessments. The formative assessment (50%) will be made through Peer learning Activity, critic a grounded theory paper, individual and group presentations, while the summative assessment (50%) will be through a written examination, and individual qualitative data gathering and analysis and finally a written grounded theory proposal in their respective fields. In this way, the students are examined with both groupwise and individual presentations. Obligatoriska moment : Active participation in the class discussions, individual and group assignments (individual and group data gathering by interviews and field observations and data analysis), written assignment (a complete grounded theory proposal) and student presentations are mandatory. Compensation according to the instructions of the course director, which means absentees less than 2 lectures is acceptable and should be compensated by individual projects related to absentee¿s session. Antal studenter : 10 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is held at Department of Clinical Science and Education at Södersjukhuset in Stockholm. Kursansvarig : Hamid Khankeh Institutionen för klinisk forskning och utbildning, Södersjukhuset [email protected] Sjukhusbacken 10 118 83 Stockholm Kontaktpersoner : Jeanette Brynholt Ohrman Institutionen för klinisk forskning och utbildning, Södersjukhuset 086162935 [email protected] Title : Introduktionskurs i R datahantering, analys och grafisk presentation Kursnummer : 2657 Antal högskolepoäng : 1.5 Datum : 20151105 20151127 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Laboratory Medicine Särskild behörighet : Grundläggande statistikkunskaper (motsvarande "Grundläggande kurs i medicinsk statistik") Kursens lärandemål : Efter kursen ska doktoranden kunna använda R för datahantering, statistisk analys och grafisk presentation av data. Man ska också kunna installera nya funktioner i R. Kursens innehåll : R är ett kraftfullt program/programspråk för analys och grafisk presentation av data. R är helt kostnadsfritt och i de flesta ett fullgott alternativ till kommersiella statistikprogram. Programspråket är helt textbaserat vilket gör det svårare att komma igång med jämfört med program som har ett grafiskt gränssnitt. När man behärskar det ger det dock en större flexibilitet, bättre kontroll över analyserna och en automatisk dokumentation av utförda analyser. Kursens fokus ligger på struktur och grundläggande funktioner i programspråket R. Därutöver presenteras ett urval av funktioner för datahantering, statistisk analys och grafik. De metoder som tas upp är sådana som vanligen används inom klinisk medicinsk forskning (t.ex. ttest, chi2test, regressionsanalys, överlevnadsanalys, boxplot, linje, punkt, stapel och cirkeldiagram). Kursen fokuserar på hur de statistiska metoderna utförs i R och inte t.ex. deras teoretiska bakgrund, användningsområden eller tolkning. Arbetsformer : Föreläsningar och praktiska övningar. Examination : Varje kursdag avslutas med praktiska övningsuppgifter som löses enskilt. Korrekta lösningar krävs för godkänd kurs. Obligatoriska moment : Föreläsningar och inlämningsuppgifter är obligatoriska. Antal studenter : 10 20 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : Kursdatum: 56/11, 13/11, 20/11, 27/11. Egen laptop behövs för de praktiska övningarna. Kursen hålls vid Karolinska Universitetssjukhuset, Huddinge. Kursansvarig : Jonatan Lindh Institutionen för laboratoriemedicin 0858581201 [email protected] Avd. för klin. farmakologi, C1:68 Karolinska universitetssjukhuset Huddinge 14186 Stockholm Kontaktpersoner : Marine Andersson Institutionen för laboratoriemedicin 08585 81064 [email protected] Title : Metoder för statistisk analys: Från variansanalys till multilevel modeling Kursnummer : 2666 Antal högskolepoäng : 4.0 Datum : 20151012 20151030 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Clinical Neuroscience Särskild behörighet : Kursens lärandemål : Efter genomgången kurs ska studenterna kunna använda sig av följande statistiska analysmetoder: (1) Variansanalys; (2) Multipel regressionsanalys; (3) Risk och Oddskvoter; (4) Logistisk regression; (5) Cox regression; (6) Faktoranalys; (7) Strukturekvationsmodellering; (8) Multilevel Modeling. Kursens innehåll : De ovan angivna statistiska analysmetoderna. Arbetsformer : Kursen består av föreläsningar och datorövningar. Föreläsningarna kommer att täcka det teoretiska materialet och beskrivas med relevanta exempel. I datorövningarna kommer de olika analysmetoderna att användas på givna data. Vid datorövningarna används programmet SPSS. Examination : Kursen examineras genom att studenterna utför de i kursen ingående analysmetoderna samt presenterar och tolkar resultaten från dessa i form av en skriftlig rapport. Obligatoriska moment : Inga obligatoriska moment. Antal studenter : 15 25 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : Datum med undervisning: 8/10; 14/10; 15/10; 19/10, 22/10; 27/10; 29/10; Vi håller till i Huddinge; En stor del av undervisningen finns tillgänglig på nätet. Kursansvarig : Kimmo Sorjonen Institutionen för klinisk neurovetenskap [email protected] Kontaktpersoner : Miriam Entesarian Matsson Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Title : Evidensbaserad verksamhet inom hörsel, öron, språk och tal Kursnummer : 2668 Antal högskolepoäng : 4.5 Datum : 20150901 20151218 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department for Clinical Science, Intervention and Technology Särskild behörighet : Kursens lärandemål : formulera och motivera en klinisk/motsvarande forskningsfråga inom verksamhet och forskningsfälten hörsel, öron, språk eller tal självständigt söka information i primära och sekundära informationskällor och granska informationen kritiskt i enlighet med utvald evidenshierarki eller kriterier redogöra för och beräkna power samt visa förmåga att analysera effektstyrka reflektera över betydelse och konsekvenser för verksamheten samt förmedla dessa presentera, diskutera och argumentera för tillvägagångssätt och resultat skriftligt och muntligt Kursens innehåll : Kursdeltagarens kliniska/annan erfarenhet och nuvarande forskningsområde ligger till grund för formulering av en forskningsfråga inom området. Kritisk granskning av befintlig evidens sammanställs och analyseras med relevanta statistiska metoder. Resultatet bearbetas för skriftlig och muntlig presentation för olika målgrupper (t ex forskare, kliniker samt målgrupp i det omgivande samhället). Arbetsformer : Föreläsningar i metod och statistik, eget arbete och gruppövningar i granskningsprocessen, handledning samt seminarier Examination : Samtliga lärandemål examineras genom den skriftliga och muntlig rapporteringen. Obligatoriska moment : Seminarier. Form för kompensation av ev frånvaro beslutas i samråd med kursansvarig Antal studenter : 2 8 Urval av studenter : Urvalet baseras på 1) kursplanens relevans för den sökandes doktorandprojekt (enligt motivering), 2) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) Övrig information : Forskarutbildningskursen ges parallellt som kurs på avancerad nivå (då med annan kursplan och annan examinationsuppgift). Kursansvarig : Ellika Schalling Institutionen för klinisk vetenskap, intervention och teknik 0858587411 [email protected] Kontaktpersoner : Christina Hedestedt Institutionen för klinisk vetenskap, intervention och teknik [email protected] Title : Tumor microenvironment Kursnummer : 2671 Antal högskolepoäng : 1.5 Datum : 20151123 20151127 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of OncologyPathology Särskild behörighet : Kursens lärandemål : After completion of the course, the students will be able to describe and discuss the tumor microenvironment and how it contributes to the carcinogenic process. Kursens innehåll : The course is designed for PhDstudents with an interest in tumor biology. It consists of lectures and experimental demonstration. The course will specifically address the concepts of tumor associated fibroblasts and macrophages, hypoxia, tumor metabolism, metastasis and tumor vascular angiogenesis and lymphangiogenesis. Experimentally, students will be able to describe the advantages and pitfalls of laser dissection. Arbetsformer : The course will be organized with a series of lectures, experimental demonstration, group discussion and examination at the final day. Examination : To pass the course the learning outcomes of the course must be reached. This will be evaluated individually during the group discussion and based on the written exam. Obligatoriska moment : Antal studenter : 20 25 Urval av studenter : Selection of students will be based on personal motivation and the relevance of the course content for their research. Priority will be given to registered doctoral students at KI. If necessary, a further selection will be based on the date for registration as a doctoral student. Övrig information : The course will be held at CCK lecture Hall, R8:00, Karolinska University Hospital, Solna. Kursansvarig : Yujuan Zheng Institutionen för onkologipatologi [email protected] Kontaktpersoner : Teresa Frisan Institutionen för cell och molekylärbiologi 0852486385 [email protected] Berzelius väg 35 S17177 Stockholm Title : Introduction to teaching at KI Kursnummer : 2686 Antal högskolepoäng : 1.0 Datum : 20150902 20151007 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : At the end of the course we expect you to: Be able to explain general aspects of how to facilitate student learning in different teaching situations Be able to reflect upon own teaching experiences and use educational concepts in a discussion about teaching and learning Kursens innehåll : During the course we will discuss and elaborate on practical issues regarding teaching and learning in laboratory, seminars and lectures. We will discuss and work with ways to challenge students and what to do to facilitate their learning. Course participants will observe (auscultate) teaching and reflect upon their experiences. We will touch upon the role of the teacher and KI teaching policies as well as strategies for coping with stress. Arbetsformer : The course is designed to promote active learning and a variety of teaching and learning strategies will be used during the course. Examples are lectures, small group discussion, peer teaching, group work, literature studies, auscultation of teaching and reflection in groups. Examination : To satisfactorily complete this course you must demonstrate that you have reached the learning outcomes by orally presenting your reflections of literature studies and auscultation of teaching. Obligatoriska moment : The assessment seminar the last day of the course is mandatory. If absent, the student need to present his/her knowledge at a separate occasion. Antal studenter : 15 30 Urval av studenter : Priority will be given to doctoral students who have just started or soon will be involved in teaching and that have no teacher training. Övrig information : The course is scheduled 2 September, 15 September and 7 October. In addition, time for reading and auscultation must be planned by the course participants. Kursansvarig : Juha Nieminen Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Ingrid Smedberg Institutionen för lärande, informatik, management och etik 08524 837 89 [email protected] Title : Multidisciplinary perspectives on active ageing research Kursnummer : 2688 Antal högskolepoäng : 4.5 Datum : 20150921 20151217 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Kursens lärandemål : The students shall be able to: Theorize on complexity of research directed towards older people, and reflect on methodological challenges in ageing research Analyse research on ageing from a multidisciplinary perspective within the framework of different ageing theories Critically judge and hypothesize on research questions within the field of ageing from different disciplinary viewpoints Kursens innehåll : To reach the intended learning outcomes, the course will be built on the research projects of the students involved. Definitions and concepts relevant for the focus of those projects will be penetrated to make students aware of their own frame of reference and of the theory that forms a base for their research design. The course will include an overview of current ageing research issues within different professional and scientific domains in health, covering the four levels health promotion, prevention of disease and disability, rehabilitation and preservation of function. A focus on a persons resources for developing an active life, and their possible implications in research will be analysed. Arbetsformer : Lectures, seminars, study of and group discussions on scientific literature and individual work based on each student's research project. Examination : The students will be examined at a seminar, where a written assignment related to the students research project will be presented, discussed and evaluated. The paper should include an attempt to apply the perspective of empowerment as well as a multidisciplinary approach on the project. Obligatoriska moment : Active participation in the seminars, which are mandatory. Absence from a seminar must be compensated by means of a written task, suggested by the course leader. Antal studenter : 15 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) the usefulness for the applicant's future research. Övrig information : The dates for the course meetings are September 21, October1213, December 16 17, from 9.0016.00. The meetings will take place in Flemingsberg, Alfred Nobels allé 23. Doctoral students from various disciplines are welcome to apply. Kursansvarig : Elisabeth Rydwik Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Kontaktpersoner : Miriam Entesarian Matsson Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Elisabeth Rydwik Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Title : Basic Laboratory Safety Kursnummer : 2690 Antal högskolepoäng : 1.8 Datum : 20151109 20151116 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Experience of and/or education in laboratory work Kursens lärandemål : After successfully completing this course you as a student should be able to evaluate the risks associated with experiments in the laboratory. The hazards could originate from chemicals, microbiological agents, cell cultures and human blood/tissues. You should also be able to identify the needs for suitable personal protective equipment, routines for waste management and transport. In addition, you should be familiar with the regulatory framework that governs these topics, the basic needs of a safe laboratory, and be able to identify the chain of responsibilities. Kursens innehåll : The course aims at giving theoretical and practical knowledge on chemical and biological aspects of laboratory safety. Topics will deal with writing risk assessments, chemical health risks including allergy, cancer and flammable agents, handling and storage of dangerous chemicals, handling of microorganisms and cell cultures including human blood and tissue samples, laboratory acquired infections, biosafety measures including personal protection devices, ventilated workplaces, genetically modified microorganisms, biosecurity and dual use, transport of dangerous goods, waste management and the sustainable laboratory. Arbetsformer : The information will be given as lectures, group discussions, practical sessions, web tutorials and computer sessions during a total of six days. Examination : The examination is based on an individual written examination and performance of an approved risk assessment. Obligatoriska moment : Presence during some activities, like introduction, group discussions, practical sessions and examination, is compulsory according to schedule. Students can not compensate for absence during compulsory activities, but are referred to coming courses for these activities. Antal studenter : 30 42 Urval av studenter : Selection will be based on 1) date for registration as a doctoral student (priority given to earlier registration date), 2) the relevance of the course syllabus for the applicants doctoral project (according to written motivation). Övrig information : Kursansvarig : Roland Möllby Institutionen för mikrobiologi, tumör och cellbiologi 0852487175 [email protected] Kontaktpersoner : Ingela Djupedal Universitetsförvaltningen [email protected] Åsa Belin Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Anne Eklöf Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Title : Basic Laboratory Safety Kursnummer : 2690 Antal högskolepoäng : 1.8 Datum : 20150928 20151005 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Experience of and/or education in laboratory work Kursens lärandemål : After successfully completing this course you as a student should be able to evaluate the risks associated with experiments in the laboratory. The hazards could originate from chemicals, microbiological agents, cell cultures and human blood/tissues. You should also be able to identify the needs for suitable personal protective equipment, routines for waste management and transport. In addition, you should be familiar with the regulatory framework that governs these topics, the basic needs of a safe laboratory, and be able to identify the chain of responsibilities. Kursens innehåll : The course aims at giving theoretical and practical knowledge on chemical and biological aspects of laboratory safety. Topics will deal with writing risk assessments, chemical health risks including allergy, cancer and flammable agents, handling and storage of dangerous chemicals, handling of microorganisms and cell cultures including human blood and tissue samples, laboratory acquired infections, biosafety measures including personal protection devices, ventilated workplaces, genetically modified microorganisms, biosecurity and dual use, transport of dangerous goods, waste management and the sustainable laboratory. Arbetsformer : The information will be given as lectures, group discussions, practical sessions, web tutorials and computer sessions during a total of six days. Examination : The examination is based on an individual written examination and performance of an approved risk assessment. Obligatoriska moment : Presence during some activities, like introduction, group discussions, practical sessions and examination, is compulsory according to schedule. Students can not compensate for absence during compulsory activities, but are referred to coming courses for these activities. Antal studenter : 30 42 Urval av studenter : Selection will be based on 1) date for registration as a doctoral student (priority given to earlier registration date), 2) the relevance of the course syllabus for the applicants doctoral project (according to written motivation). Övrig information : Kursansvarig : Roland Möllby Institutionen för mikrobiologi, tumör och cellbiologi 0852487175 [email protected] Kontaktpersoner : Ingela Djupedal Universitetsförvaltningen [email protected] Åsa Belin Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Anne Eklöf Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Title : Measuring physical activity with focus on wearable monitors applications for clinical and epidemiological studies Kursnummer : 2693 Antal högskolepoäng : 3.0 Datum : 20151023 20151123 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Kursens lärandemål : The primary objective of the course is to promote high quality research in clinical and epidemiological studies through understanding of principles for measuring physical activity and methods for analyzing physical activity data. By the end of the course the student should be able to: 1. Reflect on the concepts relevant for the relation between physical activity and health and understand measurement principles for assessing these concepts and especially the principles of of wearable monitors such as accelerometry. 2. Choose and justify the best method of choice for assessment of physical activity in accordance with different research questions, study designs and populations. 3. Apply the best method of choice for assessment of physical activity in relation to a specific research question. 4. Design a validation or calibration study in clinical and/or epidemiological studies in different populations. 5. Analyse physical activity data and interpret the outcomes in accordance with different research questions, study designs and populations. Kursens innehåll : Assessment of physical activity using questionnaires and wearable monitors in different types of studies Sensor development and measurement principles Calibration and validation Different approaches handling and analyzing the data and outcomes Statistical considerations Interpretation of results Arbetsformer : The course has the primary focus on measurement of physical activity using accelerometry and its use in clinical and epidemiological studies. An overview of other methods to measure physical activity such as questionnaires, heart rate monitoring or a combination of different physiological measures will also be covered. The course is based on demonstrations, workshops and seminars in combination with a few lectures in order to promote a reflective, analytical and critical approach towards this research field. Students will be encouraged to be interactive in demonstrations, workshops and seminars. There will be handson experience with students wearing accelerometer throughout a week and opportunities for exploring, processing and analysis this data. Examination : The learning outcomes will be examined by a written assignment were the students apply the course content to their own doctoral projects. The written assignments will be presented and discussed in a seminar where the students are respondents and opponents on each other¿s work. After the seminar the students will be given one week to refine their work based on the feedback they are given. Obligatoriska moment : Active participation in workshops and seminars. Absence from a seminar must be compensated by means of a written task, suggested by the course leader. Antal studenter : 15 24 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is given in English. Localities will be KI Campus Huddinge, Alfred Nobels Alle 23. Course days are planned to Oct 23, Nov 24th and an examination day Nov 23. There will be assignments to do during the period of the course. The platform PingPong will be used for online learning, discussions and documents. The course consist of lectures, lab and seminars. Professor Malcom Granat, Professor Ulf Ekelund and Associate Professor Örjan are invited lecturers. Kursansvarig : Maria Hagströmer Institutionen för neurobiologi, vårdvetenskap och samhälle 0852488836 [email protected] Kontaktpersoner : Title : Metoder för systematisk litteraturöversikt Kursnummer : 2704 Antal högskolepoäng : 7.5 Datum : 20150907 20151215 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Clinical Neuroscience Särskild behörighet : Kursens lärandemål : Efter avslutad kurs förväntas deltagarna: *kunna reflektera över vilket bidrag den egna forskningsöversikten tillför kunskapsfältet och identifiera frågor som kvarstår *ha utvecklat färdigheter i användandet av forskningssyntes som en vetenskaplig process *kunna kritiskt utvärdera procedurer vid systematiska litteraturöversikter Kursens innehåll : Utveckla färdigheter att: *använda systematiskt tillvägagångssätt och att sammanfatta kunskap utifrån en vetenskaplig process *reflektera över hur den valda frågeställningen inom ramen för avhandlingsarbetet bidrar till kunskapsbasen inom aktuellt forskningsområde Centralt i kursen är att utveckla färdigheter att använda systematiskt tillvägagångssätt och att sammanfatta kunskap utifrån en vetenskaplig process. Olika syften och metoder för forskningsöversikter exemplifieras. Processen i en systematisk litteratur översikt karaktäriseras av en tydligt formulerad fråga som besvaras genom systematiska och explicita metoder för att identifiera, välja ut, kritiskt bedöma och analysera relevanta studier utifrån frågeställningen. Arbetsformer : Kursen tillhandahåller en introduktion i metoder för systematisk litteraturgenomgång. Kursdeltagaren utvecklar ett protokoll för och genomför en systematisk litteraturgenomgång som fokuserar på en valfri komponent/aspekt som kommer att appliceras i deltagarens eget avhandlingsarbete. Kritiskt bedöma och diskutera svagheter och styrkor i det egna och kursdeltagarnas protokoll och översikter (reviews). Kursen är en distanskurs på deltid som omfattar tre till fyra tillfällen om 12 dagar varav ett är slutseminarium. Under kursen varieras arbetsformerna med t.ex. föreläsningar, eget arbete, granskning av andras arbete och gruppdiskussioner, för att kursdeltagarna utifrån denna erfarenhet ska kunna reflektera över hur kunskapen inom det egna forskningsfältet byggs upp. I kursen får deltagarna prova på att arbeta systematiskt utifrån principer om forskningssyntes och även bearbeta och kritiskt granska olika procedurer för forskningsöversikter. Vid första tillfället diskuteras frågeställningen och hur den valda komponenten inom ramen för det egna avhandlingsarbetet kan användas i studentens egna forskning. Till andra tillfället görs en individuell skriftlig plan eller protokoll för hur man implementerar en systematisk forskningsöversikt utifrån frågeställningen om den valda komponenten (23 sidor, 1,5 radavstånd, 12 punkter Times, Roman). Uppgiften skickas i form av ett word dokument (döpt med ditt namn). Examination : Kursen examineras individuellt genom muntlig och skriftlig examination i form av en systematisk forskningsöversikt. För godkänd kurs krävs att lärandemålen är uppfyllda, vilket innebär godkänt resultat på den skriftliga examinationen samt aktivt deltagande i obligatoriska delar. Examinationen består av: 1) En individuell uppsats i formen av en systematisk översikt och består av en litteratur genomgång utifrån den valda frågeställningen (812 sidor, 1,5 radavstånd, 12 punkter Times Roman Fokus i den sista uppgiften kommer att vara på: a) hur kursdeltagaren har undersökt och sammanfattat den valda frågeställningen i den individuellt genomförda forskningssyntesen b) hur studenten, i en metoddiskussion, har kritiskt granskat procedurer i den egna systematiska genomgången 2) Aktivt deltagande i det sista seminariet, där den individuella uppgiften (punkt 1) presenteras och diskuteras. Examination för kursen kommer att tillhandahållas under ett år efter kursens slut. Obligatoriska moment : Deltagandet i slutseminariet är obligatoriskt. Frånvaro från det sista seminariet ska kompenseras med en skriftlig kritisk diskussion av en annan students skriftliga rapport till det sista seminariet. Antal studenter : 15 20 Urval av studenter : 1. Doktorander i Forskarskolan i vårdvetenskap har företräde över andra sökanden. <br /> 2. Doktorander har företräde över andra sökanden<br /> 3. KI doktorander har företräde över andra doktorander<br /> 4. Motivering Övrig information : Kursen är en distanskurs på deltid som omfattar fem till sex tillfällen om 12 dagar varav ett är slutseminarium.<br /> Tider och lokal<br /> Tillfälle 1: 7 september, 9.0016.00<br /> Tillfälle 2: 8 september, 9.0016.00<br /> Tillfälle 3: 9 september, 9.0016.00<br /> Tillfälle 4: 1 oktober, 9.0016.00<br /> Tillfälle 5: 5 november, frivillig handledning, OBS detta datum kan komma att ändras i samråd med er!<br /> Tillfälle 6: (detta sker i halvklass och ni kommer att närvara en av de två dagarna): 14 eller 15 december, 9.0016.00<br /> Samtliga tillfällen är på Solna campus.<br /> <br /> De två första tillfällena består av föreläsningar och hjälp att starta upp ert egna arbete. Föreläsare under dessa dagar är Agneta Pettersson, (projektledare från SBU, Statens beredning för medicinsk utvärdering), Yvonne Wengström (Karolinska Institutet) och Petter Gustavsson (Karolinska Institutet). Vid tillfälle tre får ni personlig hjälp i bibliotekets lokaler av bibliotekets kunniga personal. Dessa tre tillfällen är viktiga för att komma igång med arbetet. <br /> <br /> Kontaktperson: Ann Rudman Kursansvarig : Ann Rudman Institutionen för klinisk neurovetenskap 0739343478 [email protected] Kontaktpersoner : Miriam Entesarian Matsson Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Title : Hematopoiesis and hematopoietic stem cells in health and disease Kursnummer : 2717 Antal högskolepoäng : 2.0 Datum : 20151026 20151030 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Huddinge Särskild behörighet : None Kursens lärandemål : After the completed course, the student will be able to describe the basics of hematopoietic stem cell development, stem cell transplantation, development of different types of leukemia and a number of novel technologies and approaches for hematopoietic stem cell research and clinical treatment. The student will be able to demonstrate an interdisciplinary understanding of central concepts in hematopoietic stem/progenitor cells, regulation of hematopoiesis, engraftment and immunological aspects of stem cell transplantion and critically evaluate different methods and techniques used. The student will be able to extract and integrate information from stateoftheart lectures in combination with overview articles and literature searches on the internet within the research field. Kursens innehåll : The course covers key concepts in hematology from the laboratory to the patient in the clinic. This includes visits to hematology clinic including bone marrow sampling and ward round as well as laboratory demonstration. There will be a general overview of hematology including development of fetal and adult hematopoiesis, molecular regulation of hematopoiesis, leukemic stem cells, immunological consideration in stem cell transplantation, future treatment, stem cell homing and summary of the latest events in the normal development of hematopoiesis as well as development and treatment of hematological disorders including myeloid and lymphoid leukemia. The student will be required to take an active part, contribute and value discussions on stem cell transplantation. Arbetsformer : The pedagogic framing of this course is based on lectures with corresponding review papers. The course includes workshops with illustrative predicaments where the students are required to take an active part in the discussions. Group discussions/workshop will be conducted where the students discuss and integrate information from the lectures and review papers. The students prepare and present their examination task in a written report that is handed in after the course. Examination : Individual written project report that will be performed and handed in at the end of the course. The individual performance of each student will be evaluated separately. Obligatoriska moment : The lectures and discussions are mandatory. Compensation according to the instructions of the course director. Antal studenter : 8 30 Urval av studenter : The selection process will be based on a comprehensive assessment of the students: 1. Motivation for the course 2. Topic of their PhD project 3. Registration date (priority given to students with earlier registration date) Övrig information : The course is given in Huddinge. Kursansvarig : Julian Walfridsson Institutionen för medicin, Huddinge [email protected] Kontaktpersoner : Julian Walfridsson Institutionen för medicin, Huddinge [email protected] Title : Culture and Brain Kursnummer : 2721 Antal högskolepoäng : 2.0 Datum : 20150901 20160215 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Kursens lärandemål : After the course students should be able to describe the interplay between culture (in a wide sense of the word) our brain and health, wellbeing and learning. They shall also be able to explain different scientific paradigms by which such questions are studied. Specifically, students shall be able to 1) give examples of how experience and performance of culture are perceived by the brain, 2) give examples of how culture might be used in prevention, health care and rehabilitation, 3) also give examples where brain and educational science meet and inform each other, 4) discuss possible mechanisms, and 5) propose further studies that will increase and enhance our understanding of the field. Kursens innehåll : Inspired by the fast development in the cross disciplinary field of culture brain health, we will address questions concerning how activities and experiences in different fields of culture (music, literature, fine arts, physical activity etc) are perceived by and affect the human brain in ways that influence wellbeing, health, healing and rehabilitation, and also how processes and plastic structures in brain influence learning. The course will cover questions such as how brain perceives culture, brain plasticity, use of culture in health care and rehabilitation, and the crossroad between brain and educational research. The course will touch upon a large number of different sorts of culture, and make students familiar with different scientific paradigms in various academic disciplines studying these phenomena, and wide range of different scientific approaches and techniques. Arbetsformer : In average 12 lectures each month for five months, each immediately followed by a seminar, 23 hrs on each occasion. Lectures and seminars held by internationally leading scientists in the fields, whose work quailify to be presented on the website "Kulturella hjärnan". (www.culturalbrain.se). Every occasion consists of a appr 12 hour seminar/lecture with the invited expert followed by a two hour open discussion, i.e 34 hours on each occassion. For each seminar the students will usually be given at least one article on the topic to read. Active participation in discussions in groups with invited speaker of high international standards is a key element. You also receive DVDrecordings of all lectures for further self studies at home. Examination : On an individual basis. Continuous by workshop discussions. Written homeexam (essay). Obligatoriska moment : The seminars are compulsory. Absence can be compensated for after discussion with the course leader. Antal studenter : 10 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Ingemar Ernberg Institutionen för mikrobiologi, tumör och cellbiologi +46852486262 [email protected] Box 280, Karolinska Institutet 17177 Stockholm Kontaktpersoner : Bertha Brodin Institutionen för onkologipatologi 51775244 [email protected] Cancer Centrum Karolinska CCK R8:00 171 76 Stockholm Henrik Brändén Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Title : Writing skills for science Kursnummer : 2743 Antal högskolepoäng : 1.0 Datum : 20150813 20150816 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Cell and Molecular Biology Särskild behörighet : Kursens lärandemål : After the completed course, the students will be able to explain and relate the basic components of a good scientific manuscript in the IMRaD format, and demonstrate knowledge on the different linguistic strategies for constructing sentences and paragraphs for improved readability and flow in scientific manuscripts and other communications. Kursens innehåll : The course consists of two major parts: 1) A creative writing workshop focusing on the use of creative writing techniques for improved communication in science and in general, and in using text as a tool in communication. The creative writing workshop includes writing exercises and readings and discussions. 2) A scientific writing workshop on writing IMRaD style articles including exercises in analysing the structure of published papers. The workshop includes perspectives from an editor's point of view about factors affecting rejection or acceptance of a paper. Arbetsformer : The course includes presentations, readings, writing exercises and text analysis exercises. Examination : The students will be examined on the basis of their active participation in individual exercises (writing exercises and IMRaD style article analysis). Obligatoriska moment : The writing and text analysis exercises and readings are obligatory. Absence from compulsory parts is compensated according to the instructions from the course directors. Antal studenter : 10 15 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : This writing course is organised as an intensive weekend camp at Solvik. Participants will be able to enhance their creative and professional writing skills with instructors from Harvard Medical School, Uppsala University and Karolinska Institutet in a relaxed small group setting. The course is free of cost with basic summer camp food. The participants will live in shared accommodation and must bring their own bed linen and towels. Solvik is located in a beautiful archipelago setting in Värmdö, just half an hour from central Stockholm with public transport from Slussen. Kursansvarig : Matti Nikkola Institutionen för cell och molekylärbiologi [email protected] Kontaktpersoner : Title : The Developing Brain Kursnummer : 2780 Antal högskolepoäng : 1.5 Datum : 20150831 20150904 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neuroscience Särskild behörighet : Kursens lärandemål : By the end of the course the student shall be able to describe the major steps contributing for the development of the brain and transfer new knowledge acquired in the course into their specific projects or fields of research. The student should be able to explain basic principles behind neural development such as patterning, specification from neural stem cells to neurons and oligodendrocytes, migration, neurite outgrowth, axon pathfinding, synapse formation, neuroglia interactions, the role of neuronal activity, and regeneration final circuit integration. Describe key concepts such as epigenetic states, cell potency and faterestriction, transcriptional programs. To apply and understand the readout of modern methods of probing developmental questions including inducible genetic fatemapping, manipulation and tissue culture systems in different animal model systems as well as transcriptomic analysis. Kursens innehåll : The course will cover the main developmental steps for creating the mature circuits in the brain, including the patterning of the neural plate and thus the origin of cell types, the interplay between intrinsic and extrinsic factors, neuroglia interactions and the role of network activity in shaping the final circuits. Different molecular and tracing technologies, and model organisms will be covered. An important aspect of the course regards molecular technologies for labeling, transcriptional analysis and genetic manipulation of defined neural populations. Connections between aberrant developmental processes and neurological disorders will be covered. Arbetsformer : Lectures by invited experts, group work, seminar presentations. Examination : The students should demonstrate their knowledge about the items stated as individual learning outcomes during interaction with invited experts, group work and presentations. They should demonstrate that they can critically evaluate original research papers on these topics in a seminar presentation and in discussions. Obligatoriska moment : All lectures and the seminar presentation (examination) are compulsory. Student who cannot attend will be given the opportunity to perform an individual seminar presentation and take part in an individual exam. Antal studenter : 12 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is a full time course (09.0016.00) and will be given at the Department of Neuroscience (Room Tellus, Scheeles väg 1, 5th floor). Confirmed external speakers are: Paola Arlotta, Harvard, USA. Steve Goldman, Rochester Univ, USA. Yevgenia Kozorovitskiy, Northwestern, USA. Denis Jaubadon, Univ. Geneva, CH. Eve Seuntjens, GIGANeuroscience, BE. Kursansvarig : Jens HjerlingLeffler Institutionen för medicinsk biokemi och biofysik jens.hjerling[email protected] Kontaktpersoner : Goncalo CasteloBranco Institutionen för medicinsk biokemi och biofysik Goncalo.Castelo[email protected] Title : Present your research! Kursnummer : 2787 Antal högskolepoäng : 1.5 Datum : 20150831 20151110 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Women's and children's health Särskild behörighet : None Kursens lärandemål : The overall aim of the course is to give the Ph.D. student knowledge in presenting research results orally with support of visual media like power point slides, whiteboard, flipchart and a scientific poster. After attending the course, the Ph.D. Student should: 1. BE ABLE TO DESIGN AN ORAL PRESENTATION IN AN ADEQUATE WAY WITH EMPHASIS ON : a. Setting goals and aims for the presentation b. Structure of the presentation c. Simplification of research results in order to enhance the understanding d. Choice of pictures e. Language f. Adjusting to different presentation types like poster presentation, grant proposal, and for example your dissertation lecture, or presentation of your research results to your research group, or a journal club g. Time management: how much time do I have at my disposal and how to keep the time limits h. Basic rhetoric and presentation techniques 2. BE ABLE TO DESIGN AND USE SUPPORTIVE MEDIA FOR A SUCCESSFUL PRESENTATION: a. Power Point slides ¿ interesting and structured, adjusted to the room conditions and the audience b. Scientific poster ¿ illustrative, good flow and conclusive c. Flipchart, whiteboard and other supporting media 3. KNOW THE BASICS ABOUT HOW TO PRESENT (presentation techniques and rhetoric): a. Body language and posture b. Language and pace c. How to prepare yourself for a presentation d. How to remember what you want to present e. Building confidence (be less nervous) to present f. What to avoid doing during a presentation g. How to deal with questions from the audience 4. HAVE GAINED KNOWLEDGE ON HOW TO INTERACT WITH THE AUDIENCE: a. Catching the audience¿s attention b. Keeping the audience´s attention for a longer period of time c. How to impress your audience d. How to address the audience e. Communicating with the audience f. How to make the audience trust you g. Preparing the presentation with different audiences in mind h. Different learning styles which influences the audience´s attention i. Attention curve of the audience j. How to enhance the learning of the audience Kursens innehåll : The scope of the course is to design and give oral presentations of your research results in different contexts. The main content of the course: 1. DESIGN AND DISPOSITION OF AN ORAL PRESENTATION (poster presentation, grant proposal, short presentation of research results): a. Goals and aims b. Structure c. Simplifications to enhance understanding d. Choice of pictures e. Language f. Time management: how much time, keeping the time limits 2. PRESENTATION TECHNIQUES AND RHETORIC FOR ORAL PRESENTATIONS: a. Body language and posture b. Language and pace c. How to prepare yourself for a presentation d. How to remember what you want to present e. Building confidence (be less nervous) to present f. What to avoid doing during a presentation g. How to deal with questions from the audience 3. DESIGN AND USE OF SUPPORTING MEDIA FOR A PRESENTATION: a. Power Point slides including introduction to power point b. Scientific poster c. Flipchart, whiteboard and other supporting media 4. INTERACTION WITH THE AUDIENCE: a. Catching the audience's attention b. How to address the audience c. Keeping the audience´s attention for a longer period of time d. Communicating with the audience e. How to make the audience trust you f. Preparing the presentation with different audiences in mind g. Different learning styles which influences the audience´s attention h. How to impress your audience i. Attention curve of the audience j. How to ease the learning of the audience 5. PRACTICAL EXERCISES: a. Presenting in front of an audience: i. Grant proposal ii. Poster presentation iii. Presentation of student´s choice b. Presentation exercises in pairs or small groups c. Presenting to different audiences d. Body language e. Language and pace f. How to use your audience as an asset g. How to interact with your audience h. How to remember your presentation i. Give an receive feedback on presentations j. Deal with nervousness and stay focused on your presentation k. Video recording of presentation with feedback from different perspectives Arbetsformer : Lectures, written assignments, workshops, coaching, group work, and practical exercises in groups and with peer. Examination : Poster presentation including scientific poster, grant proposal presentation, and a presentation of your own choice. Obligatoriska moment : Three complete presentations (designed and presented to the class): q. Poster presentation including a scientific poster b. Grant proposal presentation c. One presentation of the student ´s own choise Antal studenter : 16 18 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Welcome to apply for Ph.D. course Present your research! The course takes place on the following days: 31st of August, 1st OR 2nd of September, 22nd of September, 3rd of November, 10th of November. The reason for giving the course over a longer period of time is to give you a chance to practice the skills your learn during the course. This course is suitable for anyone that wants to improve his or her presentation techniques skills; no matter if you are starting off on a beginner's level or if your skills are quite advanced. You will be working together with very experienced teachers, both in groups and individually, and we will focus on your individual needs. Different approachess and techniques are used based on the latest research in the field and we focus a lot on the participant's individual needs in terms of needs (aims, nervousness, structure, bodylangugage, voice etc) and different kinds of presentations that you might need to give. Kursansvarig : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Kontaktpersoner : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Title : Present your research! Kursnummer : 2787 Antal högskolepoäng : 1.5 Datum : 20150825 20151109 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Women's and children's health Särskild behörighet : None Kursens lärandemål : The overall aim of the course is to give the Ph.D. student knowledge in presenting research results orally with support of visual media like power point slides, whiteboard, flipchart and a scientific poster. After attending the course, the Ph.D. Student should: 1. BE ABLE TO DESIGN AN ORAL PRESENTATION IN AN ADEQUATE WAY WITH EMPHASIS ON : a. Setting goals and aims for the presentation b. Structure of the presentation c. Simplification of research results in order to enhance the understanding d. Choice of pictures e. Language f. Adjusting to different presentation types like poster presentation, grant proposal, and for example your dissertation lecture, or presentation of your research results to your research group, or a journal club g. Time management: how much time do I have at my disposal and how to keep the time limits h. Basic rhetoric and presentation techniques 2. BE ABLE TO DESIGN AND USE SUPPORTIVE MEDIA FOR A SUCCESSFUL PRESENTATION: a. Power Point slides ¿ interesting and structured, adjusted to the room conditions and the audience b. Scientific poster ¿ illustrative, good flow and conclusive c. Flipchart, whiteboard and other supporting media 3. KNOW THE BASICS ABOUT HOW TO PRESENT (presentation techniques and rhetoric): a. Body language and posture b. Language and pace c. How to prepare yourself for a presentation d. How to remember what you want to present e. Building confidence (be less nervous) to present f. What to avoid doing during a presentation g. How to deal with questions from the audience 4. HAVE GAINED KNOWLEDGE ON HOW TO INTERACT WITH THE AUDIENCE: a. Catching the audience¿s attention b. Keeping the audience´s attention for a longer period of time c. How to impress your audience d. How to address the audience e. Communicating with the audience f. How to make the audience trust you g. Preparing the presentation with different audiences in mind h. Different learning styles which influences the audience´s attention i. Attention curve of the audience j. How to enhance the learning of the audience Kursens innehåll : The scope of the course is to design and give oral presentations of your research results in different contexts. The main content of the course: 1. DESIGN AND DISPOSITION OF AN ORAL PRESENTATION (poster presentation, grant proposal, short presentation of research results): a. Goals and aims b. Structure c. Simplifications to enhance understanding d. Choice of pictures e. Language f. Time management: how much time, keeping the time limits 2. PRESENTATION TECHNIQUES AND RHETORIC FOR ORAL PRESENTATIONS: a. Body language and posture b. Language and pace c. How to prepare yourself for a presentation d. How to remember what you want to present e. Building confidence (be less nervous) to present f. What to avoid doing during a presentation g. How to deal with questions from the audience 3. DESIGN AND USE OF SUPPORTING MEDIA FOR A PRESENTATION: a. Power Point slides including introduction to power point b. Scientific poster c. Flipchart, whiteboard and other supporting media 4. INTERACTION WITH THE AUDIENCE: a. Catching the audience's attention b. How to address the audience c. Keeping the audience´s attention for a longer period of time d. Communicating with the audience e. How to make the audience trust you f. Preparing the presentation with different audiences in mind g. Different learning styles which influences the audience´s attention h. How to impress your audience i. Attention curve of the audience j. How to ease the learning of the audience 5. PRACTICAL EXERCISES: a. Presenting in front of an audience: i. Grant proposal ii. Poster presentation iii. Presentation of student´s choice b. Presentation exercises in pairs or small groups c. Presenting to different audiences d. Body language e. Language and pace f. How to use your audience as an asset g. How to interact with your audience h. How to remember your presentation i. Give an receive feedback on presentations j. Deal with nervousness and stay focused on your presentation k. Video recording of presentation with feedback from different perspectives Arbetsformer : Lectures, written assignments, workshops, coaching, group work, and practical exercises in groups and with peer. Examination : Poster presentation including scientific poster, grant proposal presentation, and a presentation of your own choice. Obligatoriska moment : Three complete presentations (designed and presented to the class): q. Poster presentation including a scientific poster b. Grant proposal presentation c. One presentation of the student ´s own choise Antal studenter : 16 18 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Welcome to apply for Ph.D. course Present your research! The course takes place on the following days: 25th of August, 26th OR 27th of August, 21st of September, 2nd of November, 9th of November. The reason for giving the course over a longer period of time is to give you a chance to practice the skills your learn during the course. This course is suitable for anyone that wants to improve his or her presentation techniques skills; no matter if you are starting off on a beginners level or if your skills are quite advanced. You will be working together with very experienced teachers, both in groups and individually, and we will focus on your individual needs. Different approachess and techniques are used based on the latest research in the field and we focus a lot on the participant's individual needs in terms of needs (aims, nervousness, structure, bodylangugage, voice etc) and different kinds of presentations that you might need to give. Kursansvarig : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Kontaktpersoner : Anna Hildenbrand Wachtmeister Institutionen för kvinnors och barns hälsa 0707890607 [email protected] Title : How to conduct systematic reviews and metaanalyses Kursnummer : 2790 Antal högskolepoäng : 3.0 Datum : 20151019 20151104 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Molecular Medicine and Surgery Särskild behörighet : Kursens lärandemål : After completion of the course the students should be able to: 1) Independently plan and produce a study protocol to perform a systematic review and metaanalysis, including a detailed description of the selection of the eligible studies and statistical methodology. 2) Critically reflect on other students individual project work in a scientifically constructive way. 3) Interpret and critically evaluate scientific studies relevant to the course content. Kursens innehåll : The course is designed for PhD students, in particular those who are at an early stage of their research education, and those with an interest in conducting systematic reviews and metaanalysis. The content of the course is as follows: 1) Basic terms in systematic reviews and metaanalyses, 2) How to write a study protocol for a systematic review, 3) How to perform a systematic literature search, 4) Data extraction and quality assessment of included studies, 5) Statistical methods used in metaanalyses and interpretation, 6) Problems and limitations of systematic reviews and metaanalysis, 7) Examination and course evaluation. Throughout the course, the students will work on an individual project and will have to peerreview the project of another student. Further, students will critically review and discuss relevant scientific articles. Arbetsformer : Lectures, seminars, individual article review, group discussions, practical sessions (one on systematic literature search, one on statistical methods) and homework tasks will be used. The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts. Therefore, much of the focus of the course is on the individual project where students are required to develop a full study protocol including several important aspects covered in the lectures, article reviews and group discussions. Students will also peerreview each other¿s projects and this will form the basis for the final examination seminar. Examination : To pass the course the student must actively participate in the course and pass the examinations: 1) Individual project work: To develop a written comprehensive yet concise study protocol including several important aspects as discussed during the course; 2) Peerreview of other students¿ projects followed by an oral presentation of their own project and opposition of other students projects during the group examination; 3) Critically review scientific articles relevant to the course content and participate actively in the seminars. Obligatoriska moment : Compulsory attendance includes the scheduled lectures and seminars. Absence will need to be replaced by individual assignments following discussion with the course coordinator, e.g. article reviews, with written or oral followup. Antal studenter : 20 25 Urval av studenter : Selection will be based on 1) Date of registration as a PhD student 2) suitability of PhD project 3) The motivation to attend the course. Övrig information : Kursansvarig : Nele Brusselaers Institutionen för molekylär medicin och kirurgi 0851770942 [email protected] UGIR Norra Stationsgatan 67 17176 Stockholm Kontaktpersoner : Kalle Mälberg Institutionen för molekylär medicin och kirurgi [email protected] Title : Medical developmental biology Kursnummer : 2794 Antal högskolepoäng : 1.5 Datum : 20150817 20150821 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neuroscience Särskild behörighet : Kursens lärandemål : After the course the doctoral student is expected to be able: To fully understand and review the basic biology and definitions of embryonic and fetal stem cells, To understand and review the most fundamental genetic and epigenetic/transcriptional regulatory mechanisms guiding the development of the essential organs, To understand and review the basic principles of regenerative medicine and perinatal physiology. Kursens innehåll : To achieve a better understanding of embryonic and fetal development, and to provide better healthcare for newborns and children, it is necessary to understand the development in basic research to be able to more rapidly apply such knowledge in clinical care. In this course, worldleading scientists in the fields of developmental biology, stem cell research, and regenerative medicine, will discuss the molecular mechanisms, cell biology, genetics and epigenetics of development in general and more specifically in a wide variety of organs, with a particular bias towards human development and disease. The nature of the course is translational and provide a wide range of knowledge from transcriptional mechanisms to basic physiology and patient care. Arbetsformer : The course is based on lectures from morning to lunch by prominent lecturers. There are practical workshops and clinical visits in the afternoons. The course is considered demanding and requires fulltime presence and attention. Examination : Every student needs to make either a fifteen minute individual presentation or to present their projects by poster presentation. The oral and poster presentations are examined by at least four course leaders and the participants receive immediate feedback directly from the course leaders/examiners. Further feedback is given continuously throughout the course. Every student will be individually assessed. Obligatoriska moment : Full presence is absolutely required. Necessary absence will be regulated with the course leader and given as extra tasks. Antal studenter : 8 14 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : This is an international exchange course between Karolinska Institutet (KI) and University of Toronto (U of T) on developmental and perinatal biology with a translational focus. It has been organised since 1996 and now has over 500 alumni. It takes place every second year in Toronto and every other second at KI, and 2015 it will take place at KI. In addition to lectures from 20 leading researchers in the field from KI and Toronto, workshops, and "meet the expert" sessions, there is also an extensive social program to allow the building of new contacts and interactions between the two universities. For 2015, this program includes visits to the Canadian Embassy and City Hall of Stockholm. The course is also closely linked to the Mats Sundin postdoc fellowship for exchange between KI and U of T. Please note that this is a fulltime course. Kursansvarig : Ola Hermanson Institutionen för neurovetenskap 46852487477 [email protected] Kontaktpersoner : Ola Hermanson Institutionen för neurovetenskap 46852487477 [email protected] Title : Introduction to Stata for epidemiologists Kursnummer : 2796 Antal högskolepoäng : 1.0 Datum : 20150914 20150915 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Kursens lärandemål : After successfully completing this course you as a student should independently be able to: use Stata to open and describe a dataset import and export datasets in different formats produce tables of descriptive statistics count and present table of counts provide a graphical presentation of continuous variables generate new variables and recode existing variables test univariable associations for continuous and categorical data Kursens innehåll : This course is designed to introduce students to the basics of Stata. It will focus on the minimum set of commands students should know to organize their own work. Specific topics include data management, datareporting, graphics and basic use of dofiles. By the end of this course, the student should be capable of using Stata independently. As motivating and instructive examples both lectures and exercises will be based on real studies published in top scientific journals. Arbetsformer : Lectures and computer exercises using Stata®. Examination : Written examination. Students who do not obtain a passing grade in the first examination will be offered a second chance to resubmit the examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. Obligatoriska moment : Examination is compulsory. Antal studenter : 12 25 Urval av studenter : Selection according to 1) the relevance of the course for the applicant's project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). Submit a completed application form and give all information requested, including a short description of current research, motivation for attending and an account of previous courses. Övrig information : The present course covers an introduction to the Stata package and basic commands for data manipulation and presentation. The content on how Stata can be used to manage and analyse epidemiological data is not covered. Kursansvarig : Nicola Orsini Institutet för miljömedicin [email protected] Kontaktpersoner : Ida Kettley Cronfalk Institutet för miljömedicin [email protected] Title : Biostatistics II: Logistic regression for epidemiologists Kursnummer : 2797 Antal högskolepoäng : 2.0 Datum : 20151207 20151216 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology" (course 1577) and "Biostatistics I: Introduction for epidemiologists" (course 1579) or corresponding courses Kursens lärandemål : After successfully completing this course you as a student are expected to be able to: choose a suitable regression model for assessing a specific research hypothesis using data collected from an epidemiological study, fit the model using standard statistical software, evaluate the fit of the model, and interpret the results. explain the concept of confounding in epidemiological studies and demonstrate how to control/adjust for confounding using statistical models. apply and interpret appropriate statistical models for studying effect modification. critically evaluate the methodological aspects (design and analysis) of a scientific article reporting an epidemiological study. Learning outcomes are classified according to Bloom´s taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Kursens innehåll : This course focuses on the application of linear and logistic regression in the analysis of epidemiological studies. Topics covered include a brief introduction to continuous and binary outcome data, univariable and multivariable models, interpretation of parameters for continuous and categorical predictors, flexible modeling of quantitative predictors, confounding and interaction, model fitting and model diagnostics. Arbetsformer : Lectures, computer lab with exercises focusing on analysis of real data sets using statistical software, exercises not requiring statistical software, group discussions, literature review. Examination : To pass the course, the student has to show that the learning outcomes have been achieved. The course grade is based solely on a written examination. The focus of the exam will be on understanding concepts and their application to analysis of epidemiological studies rather than mathematical detail. The course examination will be held within one week of the final day of the course. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. If the course is not offered during the following two academic terms then a third examination will be scheduled within 12 months of the final day of the course. Obligatoriska moment : Examination. Antal studenter : 12 25 Urval av studenter : Prerequisite knowledge equivalent to Epidemiology I and Biostatistics I or corresponding courses. Eligible doctoral students will be prioritized according to 1) the relevance of the course for their research, and 2) the stated motivation for attending the course. To be considered, please submit a completed application form and give all information requested including a short description of current research and motivation for attending, as well as an account of previous courses taken. Övrig information : The course is extended over time in order to promote reflection and reinforce learning. The course will be given the following dates: December 7, 9, 11, 14, 16. Compared to the previous version of this course, linear regression will be covered more and thus the number of higher education credits is increased to 2.0 from 1.5. Kursansvarig : Nicola Orsini Institutet för miljömedicin [email protected] Kontaktpersoner : Ida Kettley Cronfalk Institutet för miljömedicin [email protected] Title : Människans Fysiologi en översikt Kursnummer : 2827 Antal högskolepoäng : 3.0 Datum : 20151216 20160115 Språk : Svenska Nivå : Forskarnivå Kursansvarig institution : Department of Physiology and Pharmacology Särskild behörighet : Kursens lärandemål : Studenten ska efter genomgången kurs ha översiktlig kunskap och förståelse för hur människokroppens organsystem fungerar och samverkar under normala betingelser. Kursinnehållet ska kunna användas för fortsatt fördjupning inom en forskarutbildning där vissa humanbiologiska kunskaper är av värde. Färdigheter Skriftligt kunna redogöra för organsystemens funktion. Sammanställa och delge information skriftligt för utvalda fördjupningsområden. Förhållningssätt och värderingsförmåga Uppvisa ett kritiskt och vetenskapligt förhållningssätt till data som presenteras under föreläsningar och i kurslitteratur. Kursens innehåll : Nervsystemets fysiologi Muskel Autonoma nervsystemet och endokrinologi Högre hjärnfunktioner Hjärta och cirkulation Njure och syrabas Respiration Digestion Samt samspelet mellan olika organsystem. Arbetsformer : Kursen innehåller föreläsningar, gruppdiskussioner i form av frågestunder samt problembaserad undervisning. Dessutom ges en frivillig dugga som ger bonuspoäng på tentamen. Examination : För att bli godkänd i kursen måste studenten visa att lärandemålen har uppnåtts. Detta bedöms genom en skriftlig tentamen. Obligatoriska moment : Moment som är obligatoriskt under kursen är tentamen. I anslutning till kursen ges ett resttentamenstillfälle. Antal studenter : 10 20 Urval av studenter : Urval av kursdeltagare baseras på 1) datum för doktorandregistrering (där tidigare registreringsdatum har förtur) 2) kursplanens relevans för sökandes doktorandprojekt (enligt motivering). Övrig information : Bland föreläsarna kommer ni att träffa Håkan Westerblad och Bo Rydqvist. Föreläsningarna ligger för det mesta på förmiddagarna. Kursansvarig : Hakan Westerblad Institutionen för Fysiologi och Farmakologi [email protected] Kontaktpersoner : Charlotte Schönbeck Institutionen för Fysiologi och Farmakologi [email protected] Title : Introduction to Quantile Regression and Related Methods Kursnummer : 2833 Antal högskolepoäng : 1.5 Datum : 20151102 20151106 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Biostatistics I or corresponding knowledge. Kursens lärandemål : The main objective of this course is to introduce regression techniques for analyzing data arising in epidemiology, environmental health, and other global health domains. After a brief review of regression methods, the course will focus on quantile estimation. Statistical reasoning will be emphasized through problem solving and applications. At the completion of this course, a student will be able to: 1) Interpret commonly used statistics and regression methods; 2) When reading journal articles, identify potential errors and limitations in the analyses; 3) Develop judgment about which statistical technique to use in a given situation; and 4) Implement the described statistical techniques, including estimation and hypothesis testing, using statistical software. Kursens innehåll : Course Topics: The following is a tentative list of topics to be covered: 1. Descriptive statistics ¿ measures of location and dispersion; empirical quantiles 2. Advantages of using quantiles. Examples from the existing literature 3. The concept of regression. Examples of regression 4. Extending the concept of quantiles to a regression framework 5. Quantile regression: examples and applications to real datasets 6. Censored quantile regression: examples and applications to real datasets Arbetsformer : Laboratory Sessions: Lab sessions will take place every afternoon; they will be used to review the material that was covered in the lectures and to work through additional problems and computing issues. During these handson lab sessions, the students will have the opportunity to utilize the methods presented in the morning lectures to the analysis of reallife data examples. Computing: This course will provide an introduction to the R statistical package. R is free software and can be downloaded at www.rproject.org. Full information about the usage of the software will be provided during the course. Any student who has his or her own favorite statistical package is welcome to use it. The final exam does not require the use of a computer. Examination : Final assignment that assesses that all learning outcomes of the course are reached. Obligatoriska moment : Antal studenter : 15 30 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Matteo Bottai Institutet för miljömedicin 08524 870 24 [email protected] Kontaktpersoner : Johanna Bergman Institutet för miljömedicin [email protected] Nobels väg 13 17177 Stockholm Title : Philosophy of science and research ethics, statistics and oral scientific communication Kursnummer : 2839 Antal högskolepoäng : 7.5 Datum : 20150921 20151023 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : communicate own research well adjusted to different contexts by using various means of communication based on theories of communication and learning assess the quality of peers' communication of own research and give constructive feedback accordingly articulate considerations on philosophy of science and research ethics in relation to the own research project be able to perform basic summaries, analyses and presentation of data, as well as have enhanced their ability to recognize, understand and critically view the statistics being presented in medical articles Kursens innehåll : Philosophy of science and research ethics 1.5 hp Oral communication techniques 3 hp Basic statistics 3 hp Arbetsformer : The pedagogic framing is based on student activity with interactive lectures, seminars and workshops. The scheduled facetoface activities in the course will be mixed with individual work and feedback from teachers and peers via the web based platform PingPong. Examination : The knowledge, skills and attitudes acquired in the course will be assessed through written assignments and oral presentations. Obligatoriska moment : Assignments, seminar and group activities. Absence from seminar and group activities can be compensated by self studies and written assignments. Antal studenter : 24 30 Urval av studenter : The selection for this general science course will be based on your admission date to doctoral education (priority given to earlier registration date). Please make sure that you have entered the correct registration date for doctoral education in your personal profile. Övrig information : The content and focus of course 2839 is equivalent to the three independent courses 2144 "To communicate science in different contexts", 1386 "Ethics and Philosophy of Science" and 1383/2609 "Basic Course in Medical Statistics". It is required that students have not attended any of these courses previously (or their equivalent). Transfer of credits from previously attended courses will not be approved/possible. This is a five week course which requires time for independent work outside of scheduled class time. Scheduled class room sessions are on the following dates: 2125 September, 28 September2 October, 59 October, 1216 October and 1923 October. The course is given in ENGLISH. Kursansvarig : Cormac Mcgrath Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Title : The third dimension of nuclear functions Kursnummer : 2841 Antal högskolepoäng : 1.5 Datum : 20151012 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : ingen särskild behörighet efterfrågas Kursens lärandemål : Following the completion of the course the students will be able to describe the basic principles of 3D genome organisation and how this relates to nuclear functions such as transcription, replication, DNA repair and telomere maintenance. The students will also be able to design experiments for studying the 3D structure of chromatin, compartmentalisation of nuclear functions in the nuclear space and to critically evaluate results obtained with these techniques. Kursens innehåll : The course covers the basic principles of genome regulation in 3D and how marks of the primary chromatin fibre relate to the 3D structure of chromatin. Particular attention will be paid to the regulation the nuclear architecture during development, and its role in lineage specification by means of coordination of transcription and replication in space and time. Speakers will include the course organizers and several wellknown international researchers dedicated to research on relevant aspects of chromatin. Arbetsformer : The learning activities used in the course include lectures, research seminars and research article presentation by the students. Each student will present a recent publication in the form of a journal club. Students will also be encouraged to actively participate in the course. There will be substantial time for discussions after the lectures and research seminars. Examination : Examination is based on the journal club presentation and a written test. Every student will present a preselected article, and will be the opponent for the presentation of a fellow student. The student's performance at these two occasions combined with the test results will be the basis for the final assessment. Obligatoriska moment : The lectures, seminars and journal club presentations are compulsory. Compensation according to the instructions of the course director. Antal studenter : 8 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : This is a 5day (Monday to Friday) fulltime doctoral course offered by the 'Tumorbiology/Oncology doctoral programme'. The course will take place at the Department of Microbiology, Tumor and Cell Biology. Kursansvarig : Anita Göndör Institutionen för mikrobiologi, tumör och cellbiologi 08 524 862 03 [email protected] Kontaktpersoner : Anita Göndör Institutionen för mikrobiologi, tumör och cellbiologi 08 524 862 03 [email protected] Title : The cell cycle Kursnummer : 2843 Antal högskolepoäng : 1.5 Datum : 20151116 20151120 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Biosciences and Nutrition Särskild behörighet : Kursens lärandemål : Upon completion of the course the students should: Be able to explain the key aspects of the cell cycle Show uptodate knowledge on the molecular mechanisms that regulate the cell cycle. Explain the relevance of the cell cycle for health and disease. Understand and discuss diverse pharmacological strategies targeting the cell cycle. Critically evaluate different experimental models and technologies used in cell cycle research Be familiar with stateofthe art methodologies used for studies in cell cycle Be capable of designing experiments for studies on cell cycle Be able to relate the contents of the course to their specific projects and field of research Present and discuss the most recent findings in cell cycle research Kursens innehåll : The course will cover key aspects of cell cycle, including cell cycle control, DNA replication, chromosome segregation, checkpoints, mitosis and asymmetric cell division. During the course, we will openly and critically discuss the latest research advances in a broad spectrum of experimental organisms. The course will have a special focus on the molecular events that regulate the cell cycle and their relevance for human diseases, such as developmental disorders and cancer. Arbetsformer : The teaching modes will consist of lectures and research seminars by invited speakers, including time for discussions with each speaker. In addition, the students will work in groups, with a guiding tutor, to critically review original articles that are relevant to the content of the course, with specific focus on the background, the technologies and experimental models used and the significance and implication of the findings. Finally, the students will work on teams to prepare posters that summarise the most important 'takehome messages' of the course and putting them in the context of their own research activities. The original papers and the posters will be presented in a minisymposium that will take place the last day of the course. Examination : Each student will be examined by his/her individual journal club presentation and his/her contribution to the poster session that will take place during the minisymposium. All learning outcomes will be assessed. Obligatoriska moment : Attendance to the lectures, research seminars, journal clubs and mini symposium are compulsory. Compensation could be done according to the instructions of the course director. Antal studenter : 15 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : 'The cell cycle' is a 5day (Monday to Friday) fulltime doctoral course offered by the 'Developmental biology and cellular signalling doctoral programme'. The course will take place at the Bioscience and Nutrition department (South Campus, Huddinge). Kursansvarig : Victoria Menendez Benito Institutionen för biovetenskaper och näringslära [email protected] Kontaktpersoner : Title : Exploring entrepreneurial opportunities in research Kursnummer : 2844 Antal högskolepoäng : 1.5 Datum : 20151116 20151120 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : After the course, a doctoral student shall be able to; demonstrate an understanding of the opportunities of innovation, entrepreneurship and utilization, use basic business tools in their own research project, assess their new skills and reflect on the possible future effects (individual, organization or society). Kursens innehåll : The course aims to increase the awareness of the potential of innovation and entrepreneurship. It begins with an introduction to entrepreneurship, what it is and how it can be used in the doctoral education. The doctoral students are then given a number of practical business tools to use in a minor innovation projects based on their own research. Arbetsformer : The course runs over five full days, including two days of training and three days of own work. Learning activities consist of seminars and workshops as well as group and individual work. With the individual assignments the doctoral students are given the opportunity to take a closer look at the actual benefits of the new knowledge and put it into a larger context, with value for their own research. Examination : The doctoral students are examined by a written individual assignment and design of a poster. In the written assignment the doctoral student describes what they learned, how it can be utilised in their own research and reflect on the effects for the future. The poster describes a concrete example of application of the new knowledge in their own research project. Obligatoriska moment : Attendance is mandatory. The course director assesses if and in that case how absence can be compensated. Antal studenter : 10 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course will be given at KI Campus in Solna, in collaboration with the actors of the local innovation system. Kursansvarig : Hanna Jansson Institutionen för lärande, informatik, management och etik 0852483861 [email protected] Kontaktpersoner : Title : Cellbased heart regeneration Kursnummer : 2845 Antal högskolepoäng : 1.5 Datum : 20150928 20151002 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Cell and Molecular Biology Särskild behörighet : Kursens lärandemål : Upon completion of the course, the doctoral students will be able to describe important principles in studying the development of the human heart, relate these to heart disease, and critically evaluate important methods and technologies applied in the context of regenerative medicine for heart disease. Kursens innehåll : The developmental principles, logic, pathways, technology, and model systems to unravel human heart disease. Regenerative cardiology, bioartificial heart tissues and translational bench to bedside regenerative medicine. Arbetsformer : The learning modes used in the course include lectures, discussions, seminars and a one day research symposium. Examination : The students are examined with individual and group presentations on the course themes. Obligatoriska moment : Participation in the group discussions and student presentations is mandatory. Compensation is according to the instructions of the course director. Antal studenter : 20 35 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is jointly organized by SCRMC/Emerging Strategic Research Theme on Stem Cell at Hong Kong University and DBRM Research School (www.dbrm.se) at KI. The course takes place at CMB, seminar room A216, Berzelius v 35 in Solna. One day of the course is organized in the form of a research symposium at Nobel Forum. Kursansvarig : Matti Nikkola Institutionen för cell och molekylärbiologi [email protected] Kontaktpersoner : Title : Integration of Neuroimaging and Cognition in Normal Aging and Dementia Kursnummer : 2846 Antal högskolepoäng : 1.5 Datum : 20151109 20151113 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Neurobiology, Care Sciences and Society Särskild behörighet : Previous knowledge in cognitive processes, brain anatomy and neuroimaging is a requirement. Kursens lärandemål : After attending the course, the graduate student will be able to (1) describe and differentiate neural and cognitive profiles that accompany normal aging and different types of dementia (2) select the most appropriate methods in order to address scientific questions pertaining to neural correlates of cognitive functions, (3) identify, combine and test different risk factors for dementia (genetic, biological, environmental) on brain integrity and cognition, (4) compute analyses in the most commonly used neuroimaging softwares (e.g., SPM, Freesurfer). Kursens innehåll : This course focuses on the study of the neural bases of cognitive decline in normal aging and dementia. The main neuroimaging methods included in this course are: Structural MRI (including volumetry and DTI), functional MRI, molecular PET and MRI (neurotransmission (e.g., dopamine) and markers of Alzheimer's disease amyloidbeta, iron). Each day of the course constitutes a specific subtopic. Day 1 is about "the essentials" on dementia, cognitive trajectories and neural changes in normal aging and dementia. On Days 2 and 3, cognitive and neuroimaging data will be integrated (day 2: structural and functional MRI; day 3: molecular neuroimaging PET/MRI, and multimodal and multivariate imaging). On Day 4, genetic, biological and environmental modifiers of cognition and neural integrity are considered. On Day 5, an introduction to cognitive and brain plasticity in aging is provided. Arbetsformer : The course contains: (1) short lectures that provide uptodate knowledge about the brain correlates of cognitive decline in normal aging and dementia, (2) seminars where methods linking neuroimaging and cognitive data are discussed based on the literature, (3) handson sessions where the students compute analyses on real data. Each subtopic (e.g., atrophy and cognition in normal aging and dementia) includes one lecture with relevant literature, a seminar on the methods used to address the question of interest and/or handson implementing the methods on real data. Examination : The students will be evaluated on group presentations during seminars and on an individual written examination consisting of a 2page essay describing how the student can test his/her hypotheses related to his/her thesis based on the knowledge and methods acquired during the course. After the end of the course, one week is given to allow the students to send the essay. Obligatoriska moment : All parts of the course are compulsory. Absence is compensated for by a written assignment. Antal studenter : 8 20 Urval av studenter : We welcome students from different academic backgrounds (master in psychology, neuroscience, medicine, biology, engineering, neuroepidemiology). Students with specific backgrounds such as cognitive psychology and neuroscience will be prioritized. Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). Övrig information : The course is held during 5 consecutive days (MondayFriday) from ca 9.00 to 16.00 (with breaks). Address: Aging Research Center (ARC), Gävlegatan 16, 113 30 Stockholm. Kursansvarig : Grégoria Kalpouzos Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Kontaktpersoner : Alireza Salami Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Francesca Mangialasche Institutionen för neurobiologi, vårdvetenskap och samhälle [email protected] Title : Cancer and cancer stem cells Kursnummer : 2849 Antal högskolepoäng : 1.5 Datum : 20151116 20151120 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medicine, Solna Särskild behörighet : Kursens lärandemål : After completion of the course, the student will be able to describe the concept of cancer stem cells, the relationship between cancer and cancer stem cells, as well as assays to identify these stem cells. Within this framework, the student will be able to demonstrate an understanding for the development of cancer in the context of solid tumors and leukemia. In addition, the students will be able to critically evaluate the advantages and drawbacks of basic mechanisms employed for cancer treatment in the clinic. Kursens innehåll : The course covers key principles of cancer development and cancer therapies, and provides an appreciation for the concept of cancer stem cells and its implications from a clinical and basic science perspective. This includes a general overview of molecular and cellular mechanisms underlying cancer development, drug resistance, disease relapse, cancer stem cells, therapeutic stem cell transplantation and clinical care for the treatment of solid tumors and leukemia, immunological cancer related considerations, and perspectives for novel cancer therapies. The student will be required to take an active part in this course by contributing with presentations and discussions related to cancer and cancer stem cells. Arbetsformer : The pedagogic frame of this course is based on lectures combined with topicrelated research articles. The course includes workshops where the students are required to present articles, integrate the knowledge acquired from lectures and reading of the articles, and actively discuss their acquired knowledge as a group. Each student will research, prepare and present his or her examination task orally. Examination : The individual performance of each student will be evaluated separately based on their presentation of a cancer stem cellrelated topic and the feedback the students provide to their fellow students. The content and organization of the presentation and discussion will follow a format provided by the instructors. Obligatoriska moment : The lectures and discussions are mandatory. Absence is compensated according to the instructions of the course director. Antal studenter : 10 30 Urval av studenter : The selection process will be based on a comprehensive assessment of the applicants, including students and postdoctoral researchers: 1. Motivation for the course 2. Topic of their PhD project 3. Years since PhD registration (priority will be given to earlier registration date) Övrig information : The course is organised by the Department of Medicine, KI Solna and the Center for Hematology and Regenerative Medicine, KI Huddinge. The course sessions will take place at KI Solna and KI Huddinge campuses. There will be a course lunch during the course week. Kursansvarig : Natalia Landazuri Institutionen för medicin, Solna [email protected] Kontaktpersoner : Hong Qian Institutionen för medicin, Huddinge [email protected] Natalia Landazuri Institutionen för medicin, Solna [email protected] Title : Initiating entrepreneurial thinking in connection to research Kursnummer : 2852 Antal högskolepoäng : 1.5 Datum : 20150914 20151218 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : After the course, a doctoral student shall be able to; describe selected business tools for e.g. needs assessment, ideation, market analysis and business modelling, understand the qualities and challenges with interdisciplinary team work, assess their new skills and reflect on the implementation in research and development. Kursens innehåll : Entrepreneurship courses give their participants tools to come up with ideas, plan and carry out projects. These courses also increase the participants knowledge of what happens outside their own academic context. This course contains a selection of lectures from courses within everything from ideation and design to startup and business modelling. Each course is unique in that the participating doctoral student selects six (6) lectures from a sample of the courses offered within the framework of the Stockholm School of Entrepreneurship (SSES). Arbetsformer : The course is offered in evenings and parttime over one semester. The doctoral student selects, in discussion with the course director, at the beginning of the course six (6) lectures to attend. Learning activities consist of these lectures (and/or seminars), an online individual learning log and an individual reflection. With the individual assignments the doctoral student is given the opportunity to take a closer look at the actual benefits of the new knowledge and put it into a larger context, and value for their own research. Examination : The doctoral students are examined by an individual learning log and an individual assignment. In the assignment the doctoral student describes what they learned, how it can be utilised in their own research and reflect on the effects of the new knowledge. Obligatoriska moment : Attendance at six (6) selected lectures is mandatory. The course director assesses if and in that case how absence from compulsory parts can be compensated. Antal studenter : 10 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course is given by KI but individual lectures/seminars will be held at the Royal Institute of Technology (KTH), Stockholm School of Economics (SSE), Stockholm University (SU) and/or the University College of Arts, Crafts and Design (Konstfack). Find out more about the different topics/courses that will form the basis for this course at www.sses.se. The course can be completed in a shorter time period depending on individual interest. Kursansvarig : Hanna Jansson Institutionen för lärande, informatik, management och etik 0852483861 [email protected] Kontaktpersoner : Title : Translational lung cancer research Kursnummer : 2854 Antal högskolepoäng : 1.5 Datum : 20151021 20151022 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Kursens lärandemål : At the end of the course the student is expected to: Understand lung cancer tissue processing for biobanking, and extraction of DNA, RNA and proteins Know how to apply molecular techniques on clinical lung cancer tissue samples Have basic knowledge about lung cancer pathology Be oriented about the frontlines of genomic, transcriptomic and proteomic lung cancer research Understand standard and targeted therapy concepts for lung cancer, and coupled biomarker research and diagnostics. Kursens innehåll : The course aims to convey a basic understanding of how modern high throughput molecular analyses can be applied to clinical lung cancer tissue, with regard to opportunities and limitations imposed by diagnostic sampling and tissue processing. The students will be introduced to basic diagnostic algorithms, treatment strategies, cancer histopathology and molecular diagnostics, as well as to exploratory translational research in lung cancer genomics, transcriptomics and proteomics. A final goal is that the students shall be able to formulate a translational project related to their own research interest. Arbetsformer : The course will be organized as a one day lecture/seminar module (in Stockholm), followed by a second day with microscopy seminars and visits/introductions to pathology laboratory units for tissue processing, biobanking and molecular diagnostics (in Uppsala). As a basic learning process we emphasize informal critical dialectic constructive discussions throughout the course ("Filip och Fredrik pedagogic"). The students will be provided before the starting of the course with material that they should read in advance and that will be used as base for the lectures and discussions during the course days. Examination : To pass the course the students must show that they have reached the learning outcomes of the course. This will be assessed formatively during the two days "on site" and by writing a potential translational lung cancer project related to their own research interests afterwards. Obligatoriska moment : Full attendance during the two days "on site" module is compulsory. Antal studenter : 10 15 Urval av studenter : Selection of students will be based on personal motivation and the relevance of the course content for their research. Priority will be given to register doctoral students at KI and Uppsala University. If necessary, a further selection will be based on the date for registration as a doctoral student. Övrig information : The course is organised in two days. The first day, organised as lecture/seminar module, will take place at the Dept of Cell and Molecular Biology (CMB) Karolinska Institutet, Stockholm. The second day, with microscopy seminars and visits/introductions to pathology laboratory units for tissue processing, biobanking and molecular diagnostic, will be held at the Department of Pathology, Rudbeck laboratory, Uppsala University Hospital. Course directors Johan Botling [email protected] Patrick Micke [email protected] Course coordinator: Teresa Frisan [email protected] Kursansvarig : Teresa Frisan Institutionen för cell och molekylärbiologi 0852486385 [email protected] Berzelius väg 35 S17177 Stockholm Kontaktpersoner : Title : Digital photomicrography Kursnummer : 2855 Antal högskolepoäng : 1.5 Datum : 20151019 20151023 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Laboratory Medicine Särskild behörighet : Kursens lärandemål : After completing the course, the participants will have a working knowledge of the fundamentals of optical microscopy and be able to use appropriate presentation methods for conveying their research results in a clear and informative way. Multimedia software and image processing software will be used including Adobe Photoshop® as well other digital microscopy software for image acquisition. Kursens innehåll : The course will include theory and practice investigating conventionallight microscopy, dark field, ultraviolet fluorescence, phase contrast and interference (DIC). Additionally, the course will dedicate one day to confocal microscopy and the Analysis and Measurement of Data through theoretical and practical sessions. Following the mastery of microscopy, the course explores fundamentals of digital photography. The participants will be exposed to digital cameras and their proper operation. There is an overview of video and still digital cameras relative to application needs. Relevant issues such as capture, processing, transmission and storage concerns are explored. Participants will work individually with popular image editing softwares such as Adobe Photoshop® as well as other imaging softwares. Exercises have been created to develop image processing imperatives such as file resolution and type, adjusting of tones and contrast, and composition. Arbetsformer : The course will consist of lectures and practical micrography laborations. Examination : Each student's knowledge will be assesed through an oral examination during a practical microscopy laboration. Obligatoriska moment : Practical micrography sessions are compulsory, as is an overall attendance of 100%. Absence can be compensated for by completing extra work as agreed with the course organizer. Antal studenter : 10 18 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : This course has a strong theoretical and handson component evenly distributed over the five days and will run from 8:3017:00 Monday Friday in lecture room Bi515, floor 5, KTH/Teknik och Hälsa, (Bipontus) Alfred Nobels Allé 10 at KTH Huddinge University Campus. The workshop explores in good depth fundamentals of bright field microscopy, as well as various other microscopy techniques such as fluorescence and phase. A significant amount of content is also dedicated to electronic imaging and image processing using Adobe Photoshop®. This is an approved PhD course, number HL201U at KTH Royal Institute of Technology, and 2855 at Karolinska Institutet, and has a credit value of 1.5 point. The course is run in conjunction with contract education for external participants. The number of participants is limited to 18. Kursansvarig : Moustapha Hassan Institutionen för laboratoriemedicin 08585 838 62 [email protected] Kontaktpersoner : Jennifer Usterud Institutionen för laboratoriemedicin 08585 832 38 [email protected] Title : Teaching and Learning in Higher Education: educational course for doctoral students a distance course Kursnummer : 2856 Antal högskolepoäng : 4.5 Datum : 20150911 20151217 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Kursens lärandemål : At the end of the course, students are expected to: Be familiar with different roles of a professional university teacher and current conditions related to teachinglearning within higher education. Be able to use educational concepts in discussions of teaching and learning situated in Higher Education. Design teaching in regards to outcome or competency based frameworks for curriculum design and also in relation to theories of learning or research on student learning in higher education. Kursens innehåll : Roles and conditions related to being a professional university teacher. Students learning in higher education Different forms of teaching and learning activities Design of teaching for learning Arbetsformer : The course is based on theories of experiential learning, a reflective attitude and learning through participation and collaboration. Teaching is conducted via the learning platform Ping Pong and is constructed largely around the students' own reading of literature, written assignments, peer feedback and online group discussions. The majority of assignments are based on the students describing, examining and reflecting over their own teaching and relating this to literature/theory. Examination : In a final examination assignment, the participant apply course content in reviewing and discussing development of one a teaching situation related to their own practice. This is presented through a written essay. To pass the course, the participant is required to: Complete all module assignments and participate actively in group work and discussions online during the course Conduct the assignment of being a "critical friend"; observing and giving feedback on a colleagues teaching. Giving feedback to a peers´ examination assignment Pass the final examination assignment, which is judged using assessment criteria. Obligatoriska moment : Participation in group discussions online Doing the examination assignment Provide peer feedback on course and examination assignments. Antal studenter : 5 7 Urval av studenter : Priority will be given to students with planned teaching included in their individual study plan. Enter a brief motivation and indicate the area within which the teaching is to be given. Secondly, selection will be based on registration date as a doctoral student. Please make sure that you have entered the correct registration date for doctoral education in your personal profile. Övrig information : The course aims to prepare students for teaching in higher education and contribute to the professional development as teacher. The course is a distance course and teaching is conducted via the learning platform Ping Pong and is constructed largely around the students' own reading of literature, written assignments, peer feedback and online group discussions. The course is given in English. Kursansvarig : Cormac Mcgrath Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Ingrid Smedberg Institutionen för lärande, informatik, management och etik 08524 837 89 [email protected] Title : Orientation in qualitative research methods Kursnummer : 2857 Antal högskolepoäng : 1.5 Datum : 20151105 20151119 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Public Health Sciences Särskild behörighet : None Kursens lärandemål : At the end of the course the students should be able to: understand and explain the theoretical basis for the main qualitative methods understand and explain the main differences between qualitative and quantitave research know the main qualitative research methods (content analysis, phenomenography, grounded theory, narrative analysis, discourse analysis), understand the differences between them and know how to choose the method most adequate for the research question at hand plan and carry out a qualitative research interview, a focus group discussion and an observation session, including know how to handle the information gathered and analyse the data understand the ethical aspects of qualitative research and how to handle them in a professional way explain how the validity/quality is assessed in qualitative research prepare the outline of an article based on data collected during the course Kursens innehåll : Theoretical basis for qualitative research The main qualitative research methods (participant selection, data collection, handling of data, analysis) Validity/quality assessment of qualitative research Ethics in qualitative research Reading and writing qualitative research Arbetsformer : Lectures Group work Practising observations, interviewing and moderating focus group discussions Practising handling of qualitative data by hand and using software Practising how to analyse qualitative data and writing it up Seminars to discuss the experiences from the practical sessions Examination : an individual written examination to assess aquired knowledge and understanding of qualitative research assessment of the practical assignments and how the experiences are presented in the seminars the drafts for an article based on the data collected in the practical assignments to assess the understanding of the process and ablity to analyse data and condense information Obligatoriska moment : Practical assignments are compulsory and have to be carried out during the course. This cannot be compensated for. Antal studenter : 8 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course meets inperson on three consecutive Thursdays, 5 November, 12 November and 19 November; with practical assignments outside of course Kursansvarig : Rachel Irwin Institutionen för folkhälsovetenskap [email protected] Kontaktpersoner : Title : Longitudinal data analysis classical and modern statistical methods Kursnummer : 2858 Antal högskolepoäng : 3.0 Datum : 20151102 20151113 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Learning, Informatics, Management and Ethics Särskild behörighet : Basic medical statistics Kursens lärandemål : After successful completion of the course the student will be able to: 1. Understand the underlying characteristics of longitudinal data 2. Identify appropriate tests for longitudinal studies 3. Manage longitudinal datasets and prepare these for statistical analysis using statistical software program SPSS 4. Apply both simple and complex statistical methods of longitudinal data 5. Use SPSS to perform the above mentioned statistical analysis 6. Present and interpret the results of analysis Kursens innehåll : The aim of the course is to introduce statistical models and methods for the analysis of longitudinal data and to develop statistical skills of analyzing correlated data. The main focus will be on frequently used statistical methods and how these should be used to provide more insight concerning research questions in longitudinal studies. Thus the course covers both classical and modern methods to analyze longitudinal data. Topics include Univariate repeated measures analysis of variance, Multivariate repeated measures analysis of variance, Drawbacks and limitations of classical methods; General linear models for longitudinal data; Linear mixed effects models; Non linear longitudinal data models and handling missing data. The underlying mathematical theory will not be stressed, and the main focus will be on concepts and applications. Arbetsformer : Teaching methods include lectures, computer based exercise and seminars 34 scheduled days during two weeks. Participants will have access to materials from a number of studies and are given the opportunity to use the statistical software program, SPSS during practice sessions. In addition, you will have seminars, group discussion and presentations. Examination : Assessment of the intended learning outcomes by the computer based exercises (should all be approved) and the final seminar. Obligatoriska moment : Computer based exercises, seminars, presentations and some lectures are mandatory. The course leader assesses whether and if so, how absence can be compensated. Antal studenter : 18 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : The course will consist of four scheduled whole days per week for two weeks. Course dates: 2 3/11, 5 6/11, 9 10/11, 12 13/11; 2015 Kursansvarig : Mesfin Tessma Institutionen för lärande, informatik, management och etik [email protected] Kontaktpersoner : Margareta KrookBrandt Institutionen för lärande, informatik, management och etik 52487118 Margareta.Krook[email protected] Title : DNA damage and maintenance of genome integrity Kursnummer : 2859 Antal högskolepoäng : 1.5 Datum : 20151012 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : The institute of Environmental Medicine Särskild behörighet : Kursens lärandemål : After the course, the student shall be able to: Regarding knowledge and understanding, describe how exposure to various environmental agents and anticancer drugs can lead to modifications of DNA account for various types of DNA damage and how they can be analyzed, as well as the molecular mechanisms by which cells detect, signal, and repair DNA damage to maintain the integrity of the genome describe epigenetic mechanisms in relation to genome instability account for the connections between DNA damage/DNA repair capacity and human disease, particularly cancer Regarding skills and ability, plan and perform one established method used for studying genotoxic effects such as comet assay, micronuclei assay or gammaH2AXstaining Regarding judgment and approach, evaluate their own results and critically assess research papers relevant to the field of DNA damage, DNA repair and genome instability. Kursens innehåll : Drugs and many environmental pollutants such as airborne particles, hydrocarbons, metals, manufactured nanoparticles as well as different mixtures may affect the genome integrity by causing changes in the genome or epigenome. Effective maintenance and interpretation of the genome is essential for normal cell division, tissue homeostasis, and cellular and organismal fitness. DNA damage and errors in DNA replication, recombination and repair, and epigenetic mechanisms all contribute to genomic instability and tumor progression. The course focuses on the formation of DNA damage as well as molecular mechanisms devoted to the preservation of genome integrity in eukaryotic cells. Topics include DNA damage formation and analysis, DNA damage recognition and repair pathways, cell cycle checkpoint mechanisms, and DNA repair as target for therapeutic intervention. The course emphasizes the relevance of these mechanisms in human disease development. The course also includes a practical part in which the students perform one selected assay for assessing DNA damage following cellular exposure to a substance of interest for the student. The course builds on a strong core of researchers with expertise in multiple aspects of genome biology across a broad range of research areas including Toxicology, Cancer biology, and Molecular Biology research. Arbetsformer : The teaching includes lectures, seminars, laboratory sessions, oral presentations and group assignments. Examination : The students will present in an oral form their laboratory group work and demonstrate their skills in discussing their own work and the work presented by their fellow students. Obligatoriska moment : Participation in the laboratory sessions is mandatory. Absence can be compensated with an individual task. Antal studenter : 10 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) Övrig information : Kursansvarig : Kristian Dreij Institutet för miljömedicin 08524 875 66 [email protected] Kontaktpersoner : Johanna Bergman Institutet för miljömedicin [email protected] Nobels väg 13 17177 Stockholm Title : Extracellular vesicles: a tool for diagnostics and therapy. Kursnummer : 2860 Antal högskolepoäng : 2.0 Datum : 20151109 20151113 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Laboratory Medicine Särskild behörighet : Kursens lärandemål : After the completed course, the student will be able to describe the basics of extracellular vesicles (EV) biology and function as well as a number of novel technologies and approaches in EV isolation and characterization. The student can demonstrate an interdisciplinary understanding of central concepts in EV biology and critically evaluate different methods and techniques used. The student will be able to extract and integrate information from stateoftheart lectures in combination with overview articles and literature searches on the internet within the research field. Kursens innehåll : The course covers key concepts in EV biology and function from the laboratory to the patient in the clinic. This includes a general overview of EV isolation and characterization approaches, tools as diagnostics and prognostics of various diseases and the possible use of EVs in therapy. Experts will give an advanced summary of the latest events in the EVfield. The student will be required to take an active part, contribute and value discussions in workshops on relevant topics in the EVfield. Networking with students and speakers is highly encouraged in this course. Arbetsformer : The pedagogic framing of this course is based on lectures with corresponding review papers. The course includes workshops with illustrative predicaments where the students are required to take an active part in the discussions. Group discussions and workshops will be conducted where the students discuss and integrate information from the lectures and review papers. The students prepare and present their examination task in a written report that is handed in after the course. Examination : An individual written project report consisting of 2 A4 pages covering one of three topics provided by the course leaders is expected to be handed in after the course. The last date to hand in the report is 1 week after the last day of lectures on the course. The written report will be evaluated on the understanding of central concepts in EV biology and integration of discussions from the course and provided course literature. Obligatoriska moment : The lectures, workshops and discussions are mandatory. Compensation according to the instructions of the course director. Antal studenter : 10 20 Urval av studenter : Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). Post docs and master students are welcome to apply and will be accommodated if spaces are available. Övrig information : The course covers key concepts in EV biology and function from the labratory to the patient in the clinic. Invited speakers represent world leading scientists in the field including Professor Matthew JA Wood from the Department of Physiology, Anatomy and Genetics at University of Oxford. Prof. Wood is a worldleading scientist in developing RNAbased therapies for neurological diseases. He has developed systems for creating engineered exosomes which can target specific molecules to the brain, which paves the way for generating targetspecific exosomebased therapies. The course including lectures, workshops and discussions will be scheduled full time from Monday to Friday in "Cellen", Hälsovägen 79, Novum Huddinge. Time to prepare the individual examinations will be given during two days the following week. Kursansvarig : Nina Heldring Institutionen för laboratoriemedicin 0700626390 [email protected] Karolinska Institutet HERM, Novum 14157 Huddinge Kontaktpersoner : Samir ElAndaloussi Institutionen för laboratoriemedicin Samir.El[email protected] Title : Biomedical Ecology The microbiota in health and disease Kursnummer : 2861 Antal högskolepoäng : 1.5 Datum : 20151123 20151127 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Microbiology, Tumor and Cell Biologi Särskild behörighet : Kursens lärandemål : After finishing the course the student should be able to show knowledge about: the composition and function of the intestinal microbiota and its cross talk with the host. the establishment of the microbiota during different stages of life, and its impact on the development and function of the immune system and host tissues. the role of how an altered intestinal function and dysbiosis might occur in connection with different diseases/disturbances. The student should be able to show insight in: methods to study the intestinal microbiota as well as data analyses and interpretation. the microbiota as the largest metabolic organ in the body and its physiological and pathophysiological role in health and disease. the role of the hostmicroflora crosstalk for the intestinal ecology/homeostasis. Kursens innehåll : The course will cover the aspects of the composition and function of the intestinal microbiota from birth, during life and the ageing period, how it might be influenced by diet and disease, and hostmicrobe crosstalk. Sequencing techniques will be introduced for the study the microflora and compared to biochemical methods. Novel findings will be discussed by lecturers in the research frontline on the translational topics of normal flora in relation to inflammatory bowels diseases (IBD), irritable bowels syndrome (IBS) celiac disease, reumatological and neurophysiological diseases. The course will be suitable for clinical and preclinical PhD students and researchers where the microbiota is of significance, including areas such as allergy, asthma, systemic autoimmune diseases, cardiovascular diseases, obesity, rheumatology, neurophysiological disturbances such as autism spectrum disorders, chronic fatigue, nutrition including effects of pre and probiotics, diabetes, metabolic syndrome, infectious diseases and bioinformatics. The course replaces the previous course 2300. Arbetsformer : The course will combine lectures, student work shops and student seminars, and practical laboratory work lectures by well established frontline researchers in their respective fields. laboratory experiments on the students own intestinal flora. work shops/combined with focused literature studies within defined areas which will be summarized in terms of student seminars. flipped class room and peer learning using the competence of the course attendees. Examination : Summative examination includes laboratory work and student presentations that are evaluated by the respective tutor at the specific course module and written examination of the course content by multiplechoice questions covering all topics discussed. Obligatoriska moment : Laboratory work and student workshops and seminars. Participants that are absent from the laboratory part and seminars will have to present a written paper on the subject. Antal studenter : 12 24 Urval av studenter : Selection will be based on the relevance of the course syllabus for the applicant's doctoral project (according to written motivation). Övrig information : Kursansvarig : Åsa Sjöling Institutionen för mikrobiologi, tumör och cellbiologi 08524 875 04 [email protected] Kontaktpersoner : Katrin Pütsep Institutionen för mikrobiologi, tumör och cellbiologi [email protected] Title : Regulatory RNAs in Development, Disease and Evolution Kursnummer : 2865 Antal högskolepoäng : 2.0 Datum : 20151007 20151016 Språk : Engelska Nivå : Doctoral level Kursansvarig institution : Department of Medical Biochemistry and Biophysics Särskild behörighet : Kursens lärandemål : After completing the course, the students should be able to: describe the different kinds of regulatory RNAs in development, disease and evolution, and their mechanism of action describe and critically evaluate the application of emerging experimental strategies for the study of regulatory RNAs transfer the knowledge acquired in the course into their specific projects and fields of research. Kursens innehåll : The course will cover key concepts concerning regulatory RNAs and their mechanisms of action. The following themes will be covered: Different kinds of regulatory (noncoding) RNAs in eukaryotes, regulatory RNAs in development and disease, regulatory RNAs in virus and bacteria, evolution of regulatory RNAs, RNA dynamics and RNA methodologies (bioinformatics and emerging experimental strategies). Arbetsformer : The learning activities include lectures, seminars, group discussions and presentations. The students will present themselves with short chalk talks on the first day. They will be divided into groups and will have several sessions designated for groups discussions and brainstorming to transfer and apply the new knowledge acquired during the course into their specific projects and fields of research. Each group will present and discuss their conclusions from these discussions to all the other students and course directors. Examination : Examination according to the intended learning outcomes of the course will take place in form of a presentation, where the course participants will discuss the transfer of the knowledge acquired during the course into their specific projects and fields of research. Each course participant will be assessed individually. Obligatoriska moment : Lectures, seminars, group discussions and presentations are mandatory. Compensation in case of absence according to the instructions of the course director. Antal studenter : 15 30 Urval av studenter : The selection is based on relevance of the course content for their doctoral project and the personal motivation included in the course application. Övrig information : The course is full time. Most of the course lectures will be given at the main seminar room at the Scheele building, Department of Medical Biochemistry and Biophysics (A3 311). The students will participate in a Karolinska Institutet conference on Regulatory RNAs and Chromatin at the Nobel Forum, October 16th 2015, with the following speakers confirmed: Leonie Ringrose, Institute of Molecular Biotechnology, Vienna, Austria, Johan Jakobsson, Lund University, John Rinn, Harvard University, USA, Raffaella Santoro, University of Zurich, Switzerland, Marcel Dinger, Garvan Institute of Medical Research, Sidney, Australia and Tony Kouzarides, University of Cambridge, United Kingdom. The course is jointly organized by Karolinska Institutet and Uppsala University and cofunded by the doctoral programme in Regenerative medicine, doctoral programme in Cell Biology and Genetics (see https://internwebben.ki.se/en/doctoralprogrammes0) and DBRM (www.dbrm.se). <br>This course has previously been given as a one week course (1,5 hp), course number 2698. Kursansvarig : Goncalo CasteloBranco Institutionen för medicinsk biokemi och biofysik Goncalo.Castelo[email protected] Kontaktpersoner :