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2007 Annual Report
EVOLUTION
5841 S. Maryland Avenue
Chicago, Illinois 60637
OF
SCIENCE & MEDICINE
KNOWING IS NOT ENOUGH; WE MUST APPLY.
BEING WILLING IS NOT ENOUGH; WE MUST
“
—Leonardo
IN
da Vinci
THE WORLDS OF SCIENCE AND MEDICINE,
THE ONLY CONSTANT IS CHANGE.
Contents
A MESSAGE
DO.”
3
AND
BUILDING STRENGTH
4
RESEARCH, TECHNOLOGY AND CLINICAL PRACTICE KEEPS THE
TRANSFORMING CARE
8
CENTER
FROM
LEADERSHIP
AT THE
12
CULTIVATING INNOVATION
16
CREATING COMMUNITY
20
ADVANCING KNOWLEDGE
24
FINANCIALS
30
LEADERSHIP
32
CHANGE
OF
DIVISION
WORLDS.
AND THE
OF THOSE
FOSTERING DISCOVERY
UNIVERSITY
OF
CHICAGO,
THE CONSTANT EVOLUTION OF
BIOLOGICAL SCIENCES
MEDICAL
AT THE FOREFRONT
DEMANDS THAT WE EXTEND RESEARCH INTO THE BASIC BIOLOGY
OF DISEASE.
IT
REQUIRES US TO USE NEW TOOLS, SUCH AS ROBOTIC
SURGERY, TO IMPROVE TREATMENT.
IT
PROMPTS US TO COLLABORATE
WITH LOCAL HEALTH INSTITUTIONS TO CREATE A NETWORK OF MEDICAL
CARE FOR OUR IMMEDIATE NEIGHBORS.
TECHNOLOGY
RECRUITMENT & PROMOTIONS
36
FEDERAL GRANTS
38
PHILANTHROPY
50
TRANSFORMS THE WAY PEOPLE WORK AND LEARN, THE WAY
SCIENTISTS CONDUCT RESEARCH, AND THE WAY PATIENTS RECEIVE TREATMENT.
SCIENCE AND MEDICINE ARE EVOLVING, AND
MEDICAL CENTER IS STEERING THE WAY.
THE
UNIVERSITY
OF
CHICAGO
2007 ANNUAL REPORT
1
At the University of Chicago Medical Center,
evolution is more than a field of study
or classroom discussion. It is an expectation,
a way of making things better day after day. Physicians, scientists,
have improved our patients’ experiences and outcomes while
nurses, staff, students and administrators here drive institutional
reducing costs, a key component in the Medical Center’s strong
evolution. They advance our understanding of the world and of
financial performance in a difficult fiscal environment.
medicine, and apply those advances to patient care.
THIS
Another evolution in thinking is the growing bond between the
This year the pace of change has quickened. The result is an
Medical Center and the surrounding community. Our work through
institution that is constantly adapting to new methods and to
the South Side Health Collaborative has helped patients find primary
novel circumstances. It is an institution that is coming closer
care close to home, and the ongoing evolution of that program
together—forming innovative, cooperative partnerships with other
has inspired us to extend our connections to multiple health care
institutions and collaborating with the community.
centers and general care hospitals nearby.
In research and education, our ties with other institutions are
ALWAYS HAS BEEN A PLACE WHERE RESEARCH
helping us expand our reach. Our deepening relationship with
AND TEACHING MEET APPLIED MEDICINE .
N OW,
THEY
Argonne National Laboratory, a Department of Energy facility
EVOLVE TOGETHER—A SYMBIOTIC RELATIONSHIP IN WHICH
25 miles to the west, has enabled our researchers to exchange
STUDENTS LEARN FROM LEADING EXPERTS, PATIENTS
ideas and technologies with those at Argonne and to advance
BENEFIT FROM THE LATEST INNOVATIONS, AND SCIENTISTS
research in a variety of fields.
THRIVE WORKING WITH THE MOST ADVANCED TECHNOLOGY
Due to these collaborations, our reputation as a leading center for
AND LEADERS ACROSS FIELDS.
research, teaching and patient care continues to rise. Not only
was the Medical Center on the U.S. News & World Report Honor
One example of this comes from a new book, Your Inner Fish, by
Neil Shubin, PhD, associate dean for organismal and evolutionary
biology. As a paleontologist, Dr. Shubin studies fish fossils,
including a species that evolved to live on land 375 million years
Roll of the nation’s best hospitals, but also the Pritzker School of
Medicine rose another notch in the education hierarchy, making it
the fastest rising medical school in the country, moving up seven
slots since 2004.
ago. “It turns out,” he wrote, “that being a paleontologist is a
At this institution, diverging branches of science and medicine
huge advantage in teaching human anatomy… . The best road
change, evolve and continue to grow together. This is, in fact,
maps to human bodies lie in the bodies of other animals. The
written in stone.
simplest way to teach students the nerves in the human head is
to show them the state of affairs in sharks.”
That sort of cross-boundary thinking also reaches into the realm
of patient care and cost efficiency. Medical Center President
David Hefner has consolidated, standardized and streamlined
many of the Medical Center’s complex processes in ways that
Valerie B. Jarrett
Chair, University of Chicago Medical Center Board of Trustees
James L. Madara
Chief Executive Officer, University of Chicago Medical Center
Vice President for Medical Affairs, University of Chicago
Dean of the Division of the Biological Sciences and the
Pritzker School of Medicine
The words etched into this entryway encapsulate the three branches of the one
institutional tree: the University of Chicago Medical Center. “The University of Chicago
University Clinics” is inscribed above, with “The Pritzker School of Medicine” on one
side and “The Division of the Biological Sciences” on the other. As the three branches
intertwine, they distinguish and define the evolving nature of this institution.
2
UNIVERSITY OF CHICAGO MEDICAL CENTER
2007 ANNUAL REPORT
3
A pharmacy technician readies chemotherapy treatment;
U.S. News & World Report ranks UCMC’s cancer program
No. 7 nationally.
Academically, the University of Chicago fared exceedingly
neurosurgery (No. 14), kidney disease (No. 22), heart and
well in these rankings. Two bioscience graduate programs—
heart surgery (No. 23), geriatrics (No. 24) and ear, nose and
paleontology and ecology/evolutionary biology—were ranked
throat (No. 25). Additionally, the gynecology and respiratory
the best in the nation. The Pritzker School of Medicine was
disorders programs scored in the top 50. These lists put the
15 th on the list. Graduate programs in the biological sciences
University of Chicago in a class of its own in Illinois.
ranked
18 th
overall.
NO
Of more than 5,400 hospitals evaluated, the Medical Center
tied for 17 th, and because the University of Chicago scored
OTHER HOSPITAL IN THE STATE HAS EVER MADE THE
U.S. NEWS HONOR ROLL,
AND NO OTHER GRADUATE
20
highly in so many areas, it earned a spot in the magazine’s
PROGRAM HAS SCORED IN THE TOP
elite list of “Honor Roll” hospitals. Two specialty programs
EDUCATION OR THE BIOLOGICAL SCIENCES OVERALL.
IN MEDICAL
were ranked in the top 10 nationally: digestive disorders at
BUILDING STRENGTH
INNOVATION IS
U NIVERSITY ’ S
A HALLMARK OF THE
UNIVERSITY
OF
No. 6 and cancer at No. 7. Six other programs ranked in the
Physicians and professors were not the only Medical Center
top 25 of their fields: endocrinology (No. 11), neurology and
employees recognized nationally this year. In the United
CHICAGO. THE
States, the best hospital nursing staffs are honored with
Magnet status by the American Nurses Credentialing Center.
REPUTATION FOR ADVANCING THE BOUNDARIES OF
Fewer than 5 percent of hospitals nationwide have earned
EDUCATION IS SHARED—AND STRENGTHENED—BY THE
MEDICAL CENTER,
PRITZKER SCHOOL
that status. In February 2007, Medical Center nurses won that
DIVISION OF BIOLOGICAL SCIENCES AND THE
OF MEDICINE. IT ’S A REPUTATION BUILT ON THE CARE AND INNOVATION
THAT FACULTY AND STAFF EXHIBIT EVERY DAY. EVIDENCE OF IT CAN BE
FOUND IN THE NATIONAL RANKINGS, GRANT FUNDING AND AWARDS THE
INSTITUTION CONTINUES TO ACCRUE. EACH YEAR, U.S. NEWS & WORLD
R EPORT RANKS THE NATION ’ S HEALTH CARE CENTERS , AS WELL AS
COLLEGES AND GRADUATE PROGRAMS. IN 2007, AS IN YEARS PAST,
THE UNIVERSITY OF CHICAGO WAS WELL REPRESENTED ON THOSE LISTS.
THE
prestigious honor. Magnet status recognizes only hospitals
where patient care is at the highest level of excellence, with
outstanding patient outcomes and shorter stays.
University of Chicago physicians have long been recognized as
among the best in the nation. Now, with Magnet status,
Medical Center nurses are receiving recognition for their
national prominence as well.
“This was an important step for us as an institution,” said
Medical Center President David S. Hefner. “If we’re going to
focus on the most difficult cases, we have to provide superb
Opening next year, the Jules and Gwen Knapp Center for Biomedical
Discovery will house translational research programs in cancer and
other medical specialties.
4
During fiscal year 2007, the University of Chicago Medical Center
progressed in several key areas, including revenue and cost control,
under the combined leadership of David Hefner (left), president of
UCMC, and James Madara, MD, chief executive officer of UCMC and
dean of the Biological Sciences Division.
nursing care. Receiving Magnet status is evidence that we do.
It provides outside verification of the excellence of our nurses
—something we are proud of and have always known.”
2007 ANNUAL REPORT
5
Olufunmilayo Olopade, MD, won a 2006 MacArthur
Fellowship, commonly called a “genius grant.”
Jeffrey Matthews, MD, chairman of surgery, has
been a driving force in surgical innovation.
A recent addition to the faculty, Sudhir Srivastava, MD, is the world leader in totally
endoscopic coronary artery bypass surgery, a revolutionary procedure that frees the
patient from an invasive, sternum-splitting operation.
pediatric and adult patients to the University of Chicago Medical
Center or other hospitals from the scenes of emergencies and
in inter-hospital transfers. Staffed by specially trained flight
nurses, residents, dispatchers and pilots who are prepared to
fly at a moment’s notice, UCAN is one of only a few such
programs in the United States.
The past year has been a time of transition, as well as honor.
An $11.5 million National Cancer Institute grant obtained in
In 2006, the hospitals and the Biological Sciences Division
the past year has enabled Olufunmilayo Olopade, MD, and a
Individuals at the Medical Center also have earned high honors.
reorganized to create the University of Chicago Medical
team of doctors to explore new avenues of research in breast
In June, Richard Schilsky, MD, an internationally recognized
Center. By combining resources and services, the two parts
cancer. Olopade, a 2006 MacArthur Fellow, and co-principal
expert in gastrointestinal cancers, cancer pharmacology and
of the institution have been able to work more cooperatively
investigators Gini Fleming, MD, and Maryellen Giger, MD,
drug development, was named president-elect of the American
and smoothly under the umbrella leadership of CEO and
lead a team of 11 basic, clinical and population-science
Society of Clinical Oncology, the world’s leading professional
Dean James Madara.
investigators to focus on more effective ways to prevent and
organization representing physicians who care for people with
detect an aggressive type breast cancer and treat women at
cancer. Schilsky, who served as associate dean for clinical
increased risk for it.
research at the Medical Center prior to his election, will take
The organizational change is just one sign of how the institution is evolving to create a better place for inquiring, learning
and healing. Success in attracting support from public and
The University also has become a national leader in health
private sources is another. Chicago physicians and scientists
disparities research, and the nonprofit, health-focused Robert
continue to compete successfully for grants and awards that
Wood Johnson Foundation selected the Medical Center to
support their work.
distribute $6 million in grants for work in this area. Those
A $23 million National Institutes of Health grant recently
awarded to Chicago is a prime example. One of 12 Clinical
and Translational Science Awards made by NIH nationally,
grants fund numerous ways to study and eventually help
office in June 2008. And after serving as president-elect,
Jeffrey Apfelbaum, MD, the chairman of anesthesia and critical
care, recently was installed as president of the American
Society of Anesthesiologists during the organization’s annual
meeting, held this past October.
remedy the inequities in health care at clinics and research
An authority on the surgical treatment of diseases of the
institutions both here and abroad.
pancreas, bile ducts and liver, Jeffrey Matthews, MD, joined
this grant ultimately will enable researchers to provide
The Medical Center especially stands out when patients with
patients new and better treatments more efficiently and
complex diseases need urgent access to multiple specialists.
quickly. Chicago will apply that funding in a variety of ways to
Since 1983, the University of Chicago Aeromedical Network
transform research discoveries into new therapies.
(UCAN) has transported critically ill or injured neonatal,
the Medical Center team in late 2006. As chairman of
surgery, Matthews has brought new leadership to an already
well-recognized department.©
Medical Center nurses gained Magnet status in 2007,
the nation’s highest honor for nursing excellence.
6
2007 ANNUAL REPORT
7
Achatz is a star in the world of modern cuisine, doctors use
the same pioneering treatment for anyone looking for innovative
Many women from across the United States who
have lost a pregnancy in the second trimester
turn to Arthur Haney, MD, for his expertise in
performing abdominal cerclage.
ways to beat cancer.
The cancer care at the Medical Center allowed Achatz to continue
working at his popular restaurant and assembling a cookbook
that is slated to come out this year. His story was featured in
many news outlets as he went through treatment. The culinary
When a spot on his tongue first appeared, Achatz’s dentist
told him not to worry. When it got bigger he saw a doctor, but
a biopsy came back negative. When it continued to grow and
TRANSFORMING CARE
MEDICINE
TRANSFORMS THE WAY WE LIVE.
NOT
SO LONG AGO, WOMEN
MEDICAL BREAKTHROUGHS WILL CONTINUE TO CHANGE
SOCIETY. BUT THE UNIVERSITY OF CHICAGO IS TRANSFORMING LIVES
RIGHT NOW THROUGH SPECIALIZED TREATMENT AND ADVANCED CARE.
LIKE CHEF GRANT ACHATZ. RENOWNED FOR HIS AVANT-GARDE DISHES,
HE HAD BECOME A NATIONAL SENSATION BY SUMMER 2007, WINNING
RAVE REVIEWS FOR HIS RESTAURANT, A LINEA , WHICH WAS NAMED
A MERICA’ S BEST RESTAURANT BY GOURMET MAGAZINE.
pulling for the young chef who faced a terrible prospect for his
professional future and for his personal well-being.
began causing pain, discomfort while eating and impediments
The treatment worked. In December 2007, just a few months
to his speech, another doctor found a tumor. Achatz, one of
after beginning therapy, doctors told Achatz that his cancer
the world’s top chefs, had stage 4B squamous cell carcinoma
was in full remission. Achatz released a statement at the time:
of the oral tongue. Then 33, he consulted with several cancer
“Where other doctors at prominent institutions saw little hope
specialists from across the United States who all told him
of a normal life, let alone a cure, these doctors saw an oppor-
that his only treatment option was surgery to remove nearly
tunity to think differently, preserve my tongue and taste, and
three-quarters of his tongue, which would include his taste
maintain a long-term high quality of life. Through the use of a
buds. Faced with a life-threatening disease and a career-
new and rigorous chemotherapy and radiation protocol, they
threatening decision, Achatz turned to University of Chicago
were able to achieve a full remission while ensuring that the
oncologist Everett Vokes, MD, for yet another opinion.
use of invasive surgery on my tongue was not needed.”
Vokes, along with several other University of Chicago head and
In its more day-to-day operations as well, the Medical Center
neck cancer experts, suggested a clinical trial that compared
is renowned for advanced care and individualized treatments.
two slightly different combinations of chemotherapy and
Modern technology and new research drive new interventions,
radiation therapy to treat the cancer. If the first-line therapy
and patients reap the benefits of those advances.
worked, Achatz would not require surgery—saving his taste buds.
For example, couples have flown from as far as Nigeria and
For Vokes, Achatz’s treatment plan was no different from what
Norway for treatment at the Center for Reproductive Medicine
other University of Chicago patients with advanced, non-
and Fertility, a University of Chicago clinic and laboratory in
metastatic tongue cancer receive. “We’re giving Grant what we
Chicago’s West Loop. Directed by David Cohen, MD, the center
think should be the first line for the typical patient,” Vokes
serves women and couples who are searching for answers to
said in the Oct. 22, 2007, issue of People magazine. “We
complex reproductive health and infertility questions.
don’t change that because a famous chef comes here.” Though
During the past year, the center’s doctors and staff have
performed more than 300 assisted reproductive technology
GAVE BIRTH AT HOME, POLIO LEFT PEOPLE DISABLED, AND VACCINES WERE
UNCOMMON.
world and much of the mainstream media seemed to be
Susan Cohn, MD, and John Cunningham, MD, together have steadily
increased the number of pediatric clinical trials at the Medical Center.
procedures. But the number of procedures is not what makes
the center unique. It is the willingness and ability of the
physicians, nurses and staff to individualize treatments. The
facility is gaining national and international distinction as
clinicians and staff dedicate themselves to care for patients
who hope to preserve fertility prior to cancer therapies and
for those who require gestational surrogacy or egg donors.
When chef Grant Achatz was diagnosed with advanced tongue cancer, several
renowned specialists suggested he have his tongue removed. But he was able to
keep his taste buds thanks to an innovative University of Chicago clinical trial.
8
2007 ANNUAL REPORT
9
Brittany and her parents
T HE M EDICAL C ENTER
more time to transport the organ. The device may increase the
HAS RECRUITED SEVERAL
donor supply, too, by allowing a heart that might otherwise
LEADERS IN PEDIATRIC HEMATOLOGY AND ONCOLOGY
have been considered unfit for transplant to stabilize. The
WHO BRING AN UNPRECEDENTED LEVEL OF EXPERTISE
University of Chicago is the third medical center in the United
TO THAT SECTION’S RESEARCH AND THERAPIES AND
States to use the device with patients.
WHO ARE SEEKING MORE EFFECTIVE TREATMENTS FOR
Cardiac and thoracic surgeons also are exploring the use of a
CANCER AND OTHER CONDITIONS.
mechanical valve that is durable enough to last many years
without replacement and doesn’t require the patient to stay on
blood thinners indefinitely. This past fall, some Medical Center
In early 2007, Susan Cohn, MD, came to Chicago to develop
patients began participating in a study in which they received
a pediatric clinical trials office. An expert in neuroblastomas
the On-X (SP) mechanical valve, allowing them to stop taking
(cancerous nerve tumors), Cohn has helped develop the
blood thinners after six months. The FDA has approved the
infrastructure for such trials and actively encourages parents
valve for use with blood thinners; this study will determine if
to enroll their affected children in the studies.
patients can safely stop taking that medication. A similar study
The number of pediatric patients enrolled in cancer clinical
has been completed successfully in Europe, and Chicago is
trials has increased six fold during the past year with the help
one of many institutions participating in the U.S. trial.
of John Cunningham, MD, who joined the Medical Center staff
in late 2006. Cunningham, section chief of pediatric hematology
and oncology, is an internationally known expert in childhood
inflates a patient’s colon with carbon dioxide, then acquires
Valluvan Jeevanandam, MD, holds a mechanical valve—currently in
clinical trial—that may allow patients with replacement valves to stop
using blood thinners.
transplant using a three-point match—which a willing, available,
images from the CT scan to analyze the intestinal tract. Patients
have minimal discomfort during the procedure, and, unlike
traditional colonoscopy, they don’t have to undergo anesthesia.
The evolution of medicine also means improving patient care.
biological parent can provide.
In the past year, the researchers and doctors in pediatric
ground at the University of Chicago. The cardiac and thoracic
hematology and oncology have focused on coordinating their
surgery section currently is conducting two ongoing trials that
efforts with adult-oriented research at the Medical Center.
take advantage of new technology or therapies.
Cohn is teaming up with Christine Hartford, MD, a pediatric
About four years ago, 13-year-old Brittany Goodrich approached
her mother, ready to admit she had a problem. She was 5’5”,
94 pounds and obsessed with which foods to eat.
Brittany and her parents started seeing a counselor, then a
dietician and finally a psychiatrist. But months into treatment
for anorexia nervosa, Brittany was not regaining lost weight.
When her parents heard about a treatment called the Maudsley
approach, which actively involves the family during meal times,
the Goodriches sought a practicing doctor and found Daniel le
Grange, PhD, who trained at the Maudsley Hospital in London
and is the director of the eating disorders program at the
University of Chicago.
Building on his work on anorexia nervosa, Le Grange recently
published a study that shows nearly 40 percent of bulimia nervosa
participants in family-based treatment stopped binging and
purging, compared to only 18 percent of those who received
supportive psychotherapy, the standard therapy. Six months after
treatment, almost 30 percent of participants who received
family-based treatment were still abstinent compared to only 10
percent of participants who received supportive psychotherapy,
which focuses on issues underlying the eating disorder.
“Parents are in a unique position to help their adolescents
with eating disorders,” Le Grange said, “yet treatment typically
excludes them from the process. Now we have substantial evidence
that we need to bring them back in.”
Brittany has progressed at a modest pace and has gained
more than 30 pounds in the three years since she has been
seeing Le Grange.
in the colon. Instead of using an invasive scope, Dachman
technique enabling physicians to perform parental bone marrow
chromosome, the scientists found a way to perform the
technologies for new purposes. Radiologist Abraham Dachman,
colonoscopy, a procedure that uses a CT scan to look for polyps
at St. Jude Children’s Research Hospital that developed a
typical donor matches require a six-point match on a specific
The Goodrich family
MD, has been ahead of the pack with the use of the virtual
cancers and blood diseases. He was part of a research team
transplants for children without an exact donor match. While
Sometimes the evolution of medicine means using existing
Like many other specialties at Chicago, diabetes care has become
more individualized for patients. The Kovler Diabetes Center,
which opened in January 2007, offers patients examinations,
second opinions and educational opportunities. The center also
A small piece of equipment about the size of a cardboard
partners with researchers, which could lead to more clinical
moving box, for example, could mean faster recovery times and
studies and trials of innovative treatments with patients there.
increased chances for heart transplant patients. The small
The facility, which brings individual resources together under
machine, called the TransMedics Organ Care System, can hold a
one umbrella, will help to communicate and foster interaction
The new director of pediatric oncology, Stephen Skapek, MD,
beating heart and enable doctors like Valluvan Jeevanandam, MD,
between the clinical and research halves. Biochemist
is tackling kids’ cancer another way. Skapek studies several
chief of the cardiac and thoracic surgery section, to transfer a
Christopher Rhodes, PhD, oversees the center’s research side.
types of developing cells, specifically blood vessel cells in
heart without soaking it in a preservative solution and cooling
Chicago scientists are investigating wide-ranging aspects of
developing eyes and immature skeletomuscular cells. His
it. Currently, a donor heart goes into a jar filled with such a
diabetes, including its complications, the effects of new drugs,
research on how those cells grow—or don’t—will enable him
solution. Sometimes that heart doesn’t work well afterward.
genetic susceptibility and new forms of this disease.©
cancer specialist, and Mark Ratain, MD, an authority on solid
tumors and a specialist in pharmacogenetics, to test new
medications on children and young adults with cancer.
to develop ways to stymie cancer cells.
Another hurdle of heart transplantation is that the donor heart
As more patients participate in clinical trials and scientists
must be transplanted within four hours, limiting the geographic
discover new treatments for pediatric cancers and blood
boundaries of recipients. The TransMedics machine keeps the
diseases, heart patients also will be helping to break new
heart beating so that Jeevanandam and other physicians have
10
2007 ANNUAL REPORT
11
Slated to open this summer, the University of Chicago Howard T. Ricketts Lab, a new
Biosafety Level 3 facility at Argonne National Laboratory, will provide safe and ultramodern
space for scientists to conduct advanced research in biodefense and infectious disease.
Fossils of the creature, found on Ellesmere Island in Arctic
“Late-life lovin’ indicates more than just mojo.” Even ABC
Canada, are the most compelling examples yet of an animal
News couldn’t resist having a little fun with the headline,
that was at the cusp of the fish-tetrapod transition. Tiktaalik’s
“Grandma’s Still Got It: Sex Persists Into the 80s.”
skull, neck, ribs and parts of its limbs are similar to those of
four-legged animals known as tetrapods, but Tiktaalik also had
fish-like features, such as a primitive jaw, fins and scales. The
finding was featured on the cover of Nature and was the subject of back-to-back research papers. It was also the impetus
for Shubin’s recent book, Your Inner Fish: A Journey Into the
3.5-Billion-Year History of the Human Body.
While Shubin was discovering a creature that was bridging an
evolutionary gap, Michael Coates, PhD, another evolutionary
developmental biologist at Chicago, was examining how one
creature seems to defy that scientific process. Coates worked
with researchers from the University of Witwatersrand in
Johannesburg, South Africa, to show that modern lamprey
FOSTERING DISCOVERY
From 21st century research to fossils that are hundreds
of millions of years old, University of Chicago scientists
are making discoveries that reach the very foundation of
biological evolution. Paleontologist Neil Shubin, PhD,
was named associate dean for organismal biology and
anatomy at the University and provost of the Field
Museum in 2006. A few months before, with colleagues
from the Academy of Natural Sciences in Philadelphia
and Harvard University, Shubin published two reports
about Tiktaalik roseae, a 375-million-year-old species
that bridges the gap between fish and land animals.
The survey found that most people ages 57 to 85 think of sexuality as an important part of life and that the frequency of sexual
activity, for those who are active, declines only slightly from the
50s to the early 70s. The study also found that sexual activity is
closely tied to overall health, which is even more important than
age. As health declines steadily after the early 70s, so does the
prevalence of sexual activity, particularly for women.
Farr Curlin, MD, tackled an equally attention-grabbing subject: religion. An authority on the religious beliefs of
physicians, Curlin explored several facets of medicine and
religion, including what types of doctors are most and least
religious and how doctors’ religious commitments influence
their decisions to treat underserved populations.
species have remained much the same throughout at least
360 million years of independent evolutionary history.
Curlin and his colleagues surveyed 1,144 practicing physicians
from all specialties. Family physicians are found to be the
Lampreys lack jaws, teeth, scales, paired fins, and any trace
of bone or hard tissue. Some of the modern forms are parasitic
and attach themselves to and feed on other fish. Fossil lampreys are exceptionally rare, and Coates and his colleagues’
discovery of the earliest known example, found in the Eastern
most religious, psychiatrists the least. But religion appears to
play little role in the likelihood of whether a doctor will care for
the underserved; less religious doctors are found to serve that
population more frequently. Curlin also explored how conscience
and religion affect doctors’ treatment recommendations.
Cape of South Africa, revealed an extraordinary match between
ancient and modern forms. Their finding, like Shubin’s, was
featured in Nature.
DISCOVERY
Research at Chicago often leads to stimulating discussions,
SURVEYS AND RESEARCH STUDIES.
whether they focus on evolutionary biology, new technologies
MAJOR PART OF THE WORK MANY SCIENTISTS PERFORM
and treatments, or better care for patients. And no subject is
HERE , AND THE
CHICAGO
AT
ENCOMPASSES MORE THAN
COLLABORATION
H OWARD T. R ICKETTS R EGIONAL
off limits. The news stories flooded in when Stacy Tessler
Lindau, MD, MAPP, and Chicago colleagues released the
BIOCONTAINMENT LABORATORY
CHICAGO’S
results of their survey of seniors’ sex habits in The New England
OF
Journal of Medicine. Canada’s Globe and Mail trumpeted,
LABORATORY,
IS A LEADING EXAMPLE
COOPERATION WITH
A
DEPARTMENT
OF
ARGONNE NATIONAL
ENERGY
FACILITY.
Neil Shubin, PhD, has helped the world understand the evolutionary
journey of the human body in his new book, Your Inner Fish.
12
IS A
2007 ANNUAL REPORT
13
Discovery at Chicago encompasses more than surveys and
year. Bridging work from the two research organizations,
research studies. Collaboration is a major part of the work
scientists at the institute work to encourage cutting-edge
many scientists perform here, and the Howard T. Ricketts
developments in genomics and systems biology. The institute’s
Regional Biocontainment Laboratory is a leading example of
director, Kevin White, PhD, already has been awarded a
Chicago’s cooperation with Argonne National Laboratory, a
$9.1 million grant from the National Institutes of Health to study
Department of Energy facility.
the genome of the fruit fly. The award is part of a $57 million
The Ricketts lab is a new Biosafety Level 3 (BSL3) facility—
part of the National Strategic Plan for Biodefense and
Infectious Disease Research and supported by the National
scientific mission—the ENCyclopedia Of DNA Elements
(ENCODE)—to understand every part of the genome needed
for organisms to develop and survive.
Institutes of Health—that will provide biocontainment space
With the help of colleagues, White’s research could lead to
vital to scientists conducting advanced research in biodefense
important developments in how researchers study the human
Changing diabetes care
and infectious disease.
genome because so much of human disease and evolution,
Scientific inquiry and collaboration are key factors in the pursuit
of excellent health care. Endocrinologist Louis Philipson, MD,
PhD, and geneticist Graeme Bell, PhD, worked together to provide
one patient—and eventually many others—with a better way to
treat diabetes.
The first was 6-year-old Lilly Jaffe, who spent most of her
young life dealing with insulin shots, blood-glucose gauges and
constant monitoring of her diet, calories and sugar levels.
Diagnosed with Type 1 diabetes when she was just one month
old, Lilly became accustomed to a life of interrupted play and
frequent visits to the school nurse. But all that changed during
the summer of 2006, when Lilly visited physicians at the
University of Chicago Medical Center.
Before doctors and researchers around the world read about
similar cases in the Aug. 3, 2006, issue of The New England
Journal of Medicine, British scientist Andrew Hattersley had
discovered that sulfonylurea drugs used to treat Type 2 diabetes
patients also could work for certain patients with permanent
neonatal diabetes, an early-onset form of Type 1 diabetes that can
be caused by rare genetic mutations. Within weeks of Hattersley’s
pre-publication talk in May, a University of Chicago team was
preparing to treat Lilly, who had one of those mutations, with
sulfonylurea drugs.
Over a week-long stay in Chicago’s Clinical Research Center,
Philipson and Bell watched carefully as Lilly began taking pills
and was weaned off of her insulin. Six pills a day now help her
pancreas to regulate her insulin levels without shots.
Lilly became the first Chicago patient to be treated in this way for
neonatal diabetes. In the year since Lilly began her new treatment,
Philipson and Bell diagnosed more than 20 children with the
same mutation. They also have found a series of new mutations
in the insulin gene itself that causes the equivalent of Type 1
diabetes in both children and adults. Many have heard about
Lilly’s treatment through newspaper articles or television coverage,
and they have turned to the University of Chicago for hope.
Once construction of the lab is completed in early 2008,
Lilly Jaffe
14
researchers there will study the biology of emerging diseases
such as susceptibility to disease and other differences among
individuals, is based on expression of genes.
and disease-causing agents, test the usefulness of new drugs
The collaboration between Argonne and Chicago is advanta-
and vaccines, and develop novel tools to detect, treat and
geous for both institutions. Argonne scientists have the
prevent illness. The facility will meet or exceed the highest
opportunity to research topics that are outside the typical
standards for biocontainment.
realm of the Department of Energy, with easier access to stu-
“Few laboratories in the United States are capable of safely
working on multiple microbes that cause diseases such as
anthrax, plague and hemorrhagic fever,” said Olaf Schneewind,
By scanning the human genome in search of variations that may
signal recent evolution, Jonathan Pritchard, PhD, found more than
700 genes that appear to have evolved during the past 10,000
years of human evolution—and may still be evolving.
dents and fellows. And collectively, both teams have a larger
pool of scientists to work with, as well as access to different
kinds of projects and a broader scope of programs.©
MD, PhD, the Chicago microbiologist who heads the Ricketts
project. The lab will support the very best science and technology in a central, state-of-the-art facility to produce drugs,
vaccines and diagnostic devices to counter bioterrorism and
emerging infectious diseases.
Though smaller BSL3 labs are in place at the University and
at Argonne, the $31 million, 35,000-square-foot Ricketts
facility will enable researchers to study more pathogens in
Kevin White, PhD, leads the Institute for Genomic and Systems Biology,
a joint effort with Argonne National Laboratory.
greater depth. Some of the organisms considered for possible
study there are anthrax, methicillin-resistant Staphylococcus
aureus and Yersinia pestis, which causes plague.
The lab—named for Howard Taylor Ricketts, a researcher at the
University of Chicago who discovered the organisms that cause
Rocky Mountain spotted fever and typhus—is one of nine
Regional Biocontainment Laboratories funded by the National
Institute of Allergy and Infectious Disease. Work at the Ricketts
lab will support the Great Lakes Center of Excellence, a
consortium of 14 NIAID-funded research institutions in the
Midwest headed by Schneewind.
Further solidifying Chicago’s relationship with Argonne, the
Institute for Genomics and Systems Biology was created last
2007 ANNUAL REPORT
15
It also can be seen in the pediatric emergency room at Comer
Children’s Hospital. The hallways are hushed because each
consultation or exam room has a sliding glass door, which
keeps sound in—and out. A curtain inside the room shields
the patient from passers-by. The area also includes two trauma
rooms, an office for Child Protective Services and social workers,
and a pelvic exam room for victims of sexual abuse. Big-screen
TVs, computer play stations and lots of toys in the waiting
room help distract kids from what ails them. The pediatric ER
New high-speed, multi-slice CT scanners let physicians peer
into the body in ways they could only dream of a few years ago.
sees about 100 patients a day. Doctors and nurses slide in
and out of the trauma rooms, which are equipped with X-ray
HHMI investigator Bruce Lahn, PhD, (right) directs an innovative, cross-disciplinary
laboratory in the largest science building on campus, constructed to exacting
standards so that scientists can pursue research that crosses traditional boundaries
among physics, chemistry and biology.
machines and virtually all other tools needed in an emergency.
The pediatric emergency department—among the newest spaces
THE
NEW FACILITIES AT THE
MEDICAL CENTER
ENABLE
at the Medical Center—is just one example of how the University
DOCTORS AND RESEARCHERS TO TAKE ADVANTAGE OF
of Chicago is taking advantage of architectural, technological and
INNOVATIVE TECHNOLOGY, WHICH IS ONE OF THE REASONS
scientific innovation. And there is more architectural growth on
PATIENTS TURN TO THE
the horizon: The Jules and Gwen Knapp Center for Biomedical
UNIVERSITY
OF
CHICAGO
SPECIALIZED TREATMENT AND ADVANCED CARE.
Discovery is slated to open in 2008. That building—at the
corner of Drexel Avenue and 57th Street—will house researchers
studying tailor-made cancer treatments and the Ludwig Center
for Metastasis Research, as well as laboratories and office space.
Additionally, plans are in the works for the new hospital pavilion,
an 11-floor facility that will be integrated into other facilities
on the Medical Center campus. The pavilion will provide 240
private patient rooms for adult surgery and hematology/oncology,
CULTIVATING INNOVATION
WITHOUT
as well as 28 operating rooms. Cancer care, high-tech imaging,
THE RIGHT TOOLS, EVEN THE BEST DOCTORS IN THE WORLD
ARE HAMPERED .
TO
ENSURE THAT
M EDICAL C ENTER
THE
UNIVERSITY
OF
CHICAGO
PROVIDES EQUIPMENT AND FACILITIES THAT
FOSTER MEDICAL EVOLUTION BY ADVANCING RESEARCH IN THE BASIC
of robotics for a variety of surgeries that allow patients to recover
more quickly and with less pain. Doctors use the da Vinci robotic
system to make minimal incisions and precise movements
during surgeries. Surgeons here use the robot to operate on
patients with endometrial cancer and abdominal aortic aneurysms,
and to perform cardiac bypasses and prostatectomies.
neuroscience and other specialties also will be housed in the
The shorter recovery periods appeal to patients in several
pavilion. The design phase of the building is slated for com-
departments that use the Medical Center’s two da Vinci
pletion in spring 2008.
machines: cardiac, gynecological, pediatrics, transplants,
PHYSICIANS ,
RESEARCHERS AND STAFF CAN WORK AT THE HIGHEST POSSIBLE LEVELS,
During the past year, the Medical Center has advanced the use
urological and vascular. Doctors here performed 517 robotThe new hospital pavilion, currently in the planning and
design process, will combine the latest technology with
the best use of space.
assisted surgeries in 2007, ranging from removing prostates
and cysts to replacing the vaginal vault and performing liver
resections. The popularity of robot-assisted procedures has led
to frequent logistical discussions during robotic surgery meetings.
SCIENCES AND OFFERING IMPROVED PATIENT CARE.
EVIDENCE OF THIS
INTEGRATIVE SCIENCE, WHERE
Though the Medical Center has two of the massive robots,
STUDENTS AND FACULTY CONDUCT RESEARCH IN TECHNOLOGICALLY ADVANCED
robotic surgery means doctors keep them in frequent use.
LABS—AND IN CLOSE CONJUNCTION WITH THE PHYSICAL SCIENCES.
This fall, cardiothoracic surgeon Sudhir Srivastava, MD, joined
CAN BE SEEN IN THE
GORDON CENTER
FOR
each requiring a room of its own, the increasing demand for
the staff. Srivastava, a pioneer in robotic surgery, has initiated a
program that will enable patients to undergo minimally invasive
heart surgery. By way of four to five fingertip-size holes on the
side of the chest, he uses the surgical robot to perform coronary
bypass surgeries. Patients recover in dramatically less time
16
2007 ANNUAL REPORT
17
FOR
Brownian dynamics model of OmpF porin
than with traditional bypass surgery, during which the sternum
ruptures, the patient suffers serious internal hemorrhage and
Technological changes have transformed life in day-to-day
must be cracked open. And the healing process is far less
can bleed to death. With traditional surgery to repair such an
practices outside of surgery, too. The Medical Center is under-
painful than for traditional surgery, which typically requires
aneurysm, the hospital stay and recovery time may be up to
going a five-year, $70 million effort that is more than a mammoth
weeks of recovery. Srivastava, a world leader for performing
10 days. With the robotic procedure, patients can go home in
upgrade of hardware and software; it will overhaul the way the
the operation, is revolutionizing cardiothoracic surgery by
two to three days.
Medical Center processes information, especially patient medical
providing life-changing surgery—and allowing patients to return
to their daily lives quickly.
procedures. Gastroenterologist Irving Waxman, MD, is a leader
prostatectomies, with surgeons performing more than 550
in endoscopic ultrasound—an evolving technique that uses a
radical prostatectomies this year alone using the da Vinci system.
probe to capture images of thoracic and abdominal organs. This
The section, led by Arieh Shalhav, MD, also performs a variety of
procedure gives physicians new ways to treat gastrointestinal
laparoscopic kidney procedures, robotic surgeries for bladder
diseases and is part of the advanced work performed by the
cancer and numerous other treatments. As with other robotic
team at the Center for Endoscopic Research and Therapeutics.
surgeries, patient recovery is quicker—and less painful—than
The center is unique in the country for its specialized care,
with traditional surgeries requiring larger incisions.
interventional treatments and research investigation.
Sarah Temkin, MD, is one of only a few dozen doctors in the
A lot of brains work overtime at the University of Chicago. The
“brain” in Benoit Roux’s computer is so large that it doesn’t fit
in his 10-by-12-foot office in the Gordon Center for Integrative
Science. Instead, the computer is housed at Argonne National
Laboratory where it works 24 hours a day, seven days a week.
“It never sleeps,” Roux said.
Roux, PhD, studies cells, their membranes and the channels that
allow some substances to pass in and out of the tiny structures.
The computers he uses—at Argonne and other labs—work nonstop
for months at a time. The one at Argonne, for example, has
1,000 central processing units (an average personal computer has
only one) and is typically 95 percent full of jobs. For Roux, the
computers are estimating the forces between certain atoms, how
atoms or molecules bind or don’t bind to each other, and the way
certain substances permeate a cell membrane while others don’t.
Roux and his colleagues combine computational and experimental data from multiple sources. By doing so, they are able to
get a more complete story about or a more valid calculation of a
particular topic. “We try to weave a tapestry of information
together,” Roux said.
That mix of information will change as more and more computer
processing is available. For example, this fall, Argonne is starting
to assemble the IBM Blue Gene supercomputer, which, when
completed in about two years, will be the most powerful civilian
computer in the world.
Additionally, Roux and his team received a grant from the
Department of Energy for 4 million computer hours at another
facility in Oak Ridge, Tenn.
country who use robotic surgery for gynecological cancers. She
information. The Phoenix Project could not be more aptly named,
as it represents a rebirth for the hospitals’ aging computer
systems. Alex Lickerman, MD, the physician sponsor for the
upgrade, compares the progress to a submarine emerging from
the water. With the updates so far—bringing computers from
dated, text-based systems to a graphics-based interface—the
periscope is rising from the water. From now until 2009, the
submarine will start to come into view, and doctors and nurses
will be able to use the computer system to get a variety of
information, including best practices, drug interaction warnings
and medical alerts.©
has performed more than two dozen such surgeries. “It’s such
a great improvement in cancer care,” Temkin said. “Someone
can have major cancer surgery and go home the next day.”
Vascular surgeon Hisham Bassiouny, MD, has begun to use the
robotic system to treat abdominal aortic aneurysm, a condition
in which the aorta swells and becomes weak. If the aorta
Irving Waxman, MD, performs advanced endoscopic procedures
for esophageal, gastric, pancreatic, lung and rectal tumors.
are pioneering ways to use endoscopy for a new generation of
The urology section has become the state leader in robotic
“Tapestry of Information”
18
Medical Center physicians who specialize in gastroenterology
Sarah Temkin, MD, uses the da Vinci robotic system to perform
minimally invasive surgeries for gynecological cancers.
2007 ANNUAL REPORT
19
The program also has provided a way for the Medical Center
to practice more aggressive outreach and to help patients navigate the health care system, overcome barriers and clarify
misconceptions about medicine or care. So far, the collaborative has connected more than 1,500 patients with primary
care medical homes.
Part of a joint effort to create strong medical networks throughout
the South Side, University of Chicago’s John Hickner, MD, (left)
works with local physician Kwame Foucher, MD, at ACCESS
Grand Boulevard Health Center.
Patients have found that the health care facilities are convenient and well resourced. Fifteen of those centers are federally
qualified health facilities; the others are a private clinic, a
substance abuse and mental health center, and Project
Brotherhood, a clinic that serves African-American men.
CREATING COMMUNITY
THE UNIVERSITY
OF
CHICAGO MEDICAL CENTER
IS WORKING TO IMPROVE
THE QUALITY OF LIFE AND CARE NOT ONLY FOR PATIENTS WHO ENTER ITS
The rates for heart failure, diabetes, renal failure, bronchitis,
Project Brotherhood now has an even closer tie to the University
asthma and hypertension are all higher among those on Chicago’s
of Chicago. Its founder, Eric Whitaker, MD, MPH, joined the
South Side than for people in the state of Illinois as a whole.
Medical Center in October as executive vice president for
Infant mortality rates in some South Side neighborhoods are
strategic affiliations and associate dean for community-based
three to four times higher than the state average of 0.73
research. Whitaker, an authority in public health, will be a key
percent and the Chicago average of 0.9 percent.
player in implementing the Urban Health Initiative, an entity
Since 2004, when the Medical Center renovated and expanded
whose aim will be to connect patients to their communities’
its emergency room, patient visits have increased by 14 percent.
health resources, as well as to each other.
The University of Chicago’s ER is the second busiest in the
As part of the effort to collaborate with community health
city. For these reasons, helping patients who use the ER find
facilities, the Medical Center has given grants to some of its
a medical “home” by connecting them to local clinics has
partners. ACCESS, a health care organization that runs several
become a priority for the Medical Center.
clinics accessible to South Side residents, received $350,000
More than two years ago, the Medical Center began working to
to increase the number of exam rooms at one of its sites.
put some of its emergency room patients in touch with primary
At these outside facilities, patients can seek primary care for
care physicians in the surrounding areas. After sick patients
basic health concerns and also receive treatment in some spe-
came to the Medical Center for urgent care, patient advocates
cialty areas. Pregnant women with a low risk of complications
helped connect those who didn’t have family doctors or regular
can visit obstetricians and even deliver their babies at some
care to area clinics where they could receive follow-up
of these partner clinics. The care they receive is every bit as
medical attention.
good as what they would receive at the University of Chicago,
Emergency room physicians, nurses and other staff were
but the facilities are closer to home and, often, have more
relieved to know that their patients could get care after their
beds available.
visits to the Medical Center ER, said James Walter, MD, chief
The South Side Health Collaborative, initially led by Michelle
of emergency medicine.
Obama, vice president for community and external affairs, has
become a model for the Medical Center’s work with the Urban
DOORS BUT ALSO FOR THOSE IN THE COMMUNITY SURROUNDING THE
BY
CAMPUS.
CENTERS,
THE SOUTH SIDE OF CHICAGO, ONE OF THE PRIMARY AREAS
FROM WHICH MEDICAL CENTER PATIENTS COME, IS HOME TO 1.1 MILLION
RESIDENTS. BUT THE HEALTH OF THOSE RESIDENTS IS OFTEN RELATIVELY
POOR , AS REFLECTED IN EXTRAORDINARILY HIGH RATES OF COMMON
DISEASES AND INFANT MORTALITY.
TEAMING UP WITH
UNIVERSITY
19
CHICAGO
FOLLOW-UP
OF
TO HELP PATIENTS FIND
COMMUNITY-BASED HEALTH
HAS BEEN ABLE
TREATMENT OR A
REGULAR PHYSICIAN.
Health Initiative. But the emergency room is a gateway to
another issue that doctors, nurses, researchers and staff are
helping to solve: disparities in health care.
“We’re a canary in the mineshaft,” said Thomas Fisher Jr.,
The health care centers, all on the city’s South Side, have been
MD, PhD, an emergency medicine physician and health dis-
able to meet, coordinate and team up—something that had not
parities researcher, speaking of the types of patient ailments
happened before—through the South Side Health Collaborative.
seen in the ER. This fall, the Hyde Park native is launching
Eric Whitaker, MD, MPH, guides efforts to create tighter bonds with the community
through progressive programs related to the Urban Health Initiative.
20
2007 ANNUAL REPORT
21
focus groups both inside and outside of the Medical Center—
The University also has become a leader in educating medical
and Reflection, during which they painted fences, planted
with doctors and administrators, primary care providers and
students about health care disparities. In fall 2006, Monica
gardens, cleaned beaches and bonded with community
patients. Fisher will be working with a leadership committee
Vela, MD, assistant professor of medicine, led an optional,
members, co-workers, family and friends.
of area residents in an effort to encourage community members
week-long orientation course on that topic. Two-thirds of the
and health care providers to focus on special needs in the
first-year medical students and 30 faculty members participated
area and to empower the community with tools to fill gaps in
in lectures and visits to local clinics.
health care.
Thomas Fisher Jr., MD, MPH, with patient
22
parade through the city streets. Hundreds of hospital employees
and their friends and family turn out annually to participate
To help build that leadership are grants totaling $6 million from
Vela said. Students gained a new view of health care and an
in the event.
the Robert Wood Johnson Foundation. The grants are distributed
introduction to the special needs of some communities. Within
in part by Marshall Chin, MD, who leads the Finding Answers:
the past year, Vela has seen an increase in the number of
Disparities Research for Change program. For the past decade,
students who attended health disparities conferences or who
Chin has worked with the Health Disparities Collaborative, a
requested that the Medical Center sponsor more events related
nationwide network of more than 1,000 health centers that aim
to disparities. There also has been more participation in student-
to make medical care more equitably accessible for underserved
driven free clinics and community roles. This past fall, the health
groups. A major review of literature about disparities in health
care disparities course was required for incoming students.
Other employees reach out to high school or middle school
students through science fair coaching or judging, job shadowing
and mentoring. Nubia Chaidez, a community relations officer
for the Medical Center, said the mentoring programs are a way
for hospital staff and community members to learn more
about each other. The mentoring program, which brings six to
eight local high school students to the Medical Center to learn
The Medical Center reaches out to the community in many ways,
about clinical and non-clinical hospital work, helps create a
in addition to clinical initiatives and research. For the past
pipeline to the health care industry. Students learn that they can
five years, scores of faculty and staff have gathered each May
be lawyers, marketing consultants or other types of hospital
Other University researchers have focused on specific conditions
to participate in service projects in surrounding neighborhoods.
administrators—not just doctors, nurses or other clinicians. ©
that tend to afflict certain races or ethnic groups more than
This year, a record 200 people came to the Day of Service
journal Medical Care Research and Review. All 20 authors
Growing up in Hyde Park, Thomas Fisher Jr. saw social and
racial imbalances all around him. “What I noticed were larger
issues of societal inequities,” he said, not just disparities related
to health care. Education and services were not as available to
the poor or to people of color as they were to others. But health
care, Fisher said, is different. “It’s not just about resources. It’s
intrinsic to the ability of a person to be productive in society.”
Through undergraduate studies at Dartmouth and medical
school at the University of Chicago, Fisher’s interest in the subject
grew. Before earning his medical degree and completing an
emergency medicine residency at the Medical Center, he decided
to pursue a master’s degree in public health at Harvard.
Fisher’s interest in health disparities has gone beyond his
coursework. He worked with Eric Whitaker, MD, MPH, on Project
Brotherhood, a clinic that pledges “to improve the health and
welfare of African-American men.” He also teaches and works at
the University’s Center for the Study of Race, Politics and Culture.
Since he began working as an emergency medicine physician
a little more than a year ago, Fisher has initiated a focus group
that will both target inequities in community health care and
offer solutions. That research, supported by a grant from the
Department of Medicine, complements other disparities work
throughout the Medical Center.
Working at Chicago has given Fisher a chance to return to his
roots and pursue his passion. “My goal here is to be a change
agent,” he said. “This is work that needs to be done.”
parade, a decades-long tradition each fall during which children
“It served as an ignition or fuel for them wanting to learn more,”
care has been published as a 300-page supplement to the
“A change agent”
Any year isn’t complete without the South Side’s Bud Billiken
work at the University of Chicago.
others. Geneticist Rick Kittles, PhD, focuses his research on
why black men are more susceptible to prostate cancer than
white men. In addition, the Center for Interdisciplinary Health
Disparities Research, supported in part by a national SPORE
The Salinas family of Calumet City has found a medical home with Chicago
Family Health Center, one of 19 South Side Health Collaborative partners.
(Specialized Program of Research Excellence) grant and led by
researchers Olufunmilayo Olopade, MD, Gini Fleming, MD, and
Maryellen Giger, MD, will aim to determine, among other things,
why black women are more likely to suffer from an aggressive
and more deadly type of breast cancer than white women.
Icy Cade-Bell, MD, provides on-location health
checks for neighborhood children via the pediatric
Mobile Healthcare Van.
2007 ANNUAL REPORT
23
The University of Chicago and Cambridge University are the only sources of access for
graduate students interested in HHMI’s new biomedical research campus in Virginia, the
Janelia Farm Research Cooperative.
In the past year, Pritzker students have received research
biomedical questions. The program grants a PhD in biology
funding from the Howard Hughes Medical Institute, the Fogarty
and features flexible training and the opportunity to research
International Center for Advanced Study in the Health Sciences
in a collaborative, interdisciplinary environment.
and the Fulbright Scholar Program, and have been awarded
two Alpha Omega Alpha Student Research Fellowships. Another
ADVANCING KNOWLEDGE
WITH SO MANY BRIGHT, FOCUSED STUDENTS AT THE PRITZKER SCHOOL
OF MEDICINE AND IN THE BIOLOGICAL SCIENCES DIVISION, EVOLUTION
IS INEVITABLE. EACH CLASS BRINGS A NEW SET OF EXPERIENCES AND
KNOWLEDGE, AND STUDENTS ARE HELPING TRANSFORM THE RESEARCH
IN THESE CORRIDORS. SINCE HOLLY HUMPHREY, MD, BECAME DEAN FOR
MEDICAL EDUCATION IN 2003, APPLICATIONS TO THE MEDICAL SCHOOL
HAVE INCREASED 69 PERCENT, COMPARED WITH AN 8 PERCENT INCREASE
FOR MEDICAL SCHOOLS NATIONALLY. WHILE THE TOTAL NUMBER OF
APPLICANTS HAS BEEN ON THE RISE, SO HAS THE PERCENTAGE OF
UNDERREPRESENTED MINORITIES, WHICH HAS INCREASED TO ABOUT 23
PERCENT, FROM 14 PERCENT JUST A FEW YEARS AGO. BOTH INCREASES
HAVE RESULTED IN A HIGH-PERFORMING AND DIVERSE CLASS OF STUDENTS.
three students have been named Albert Schweitzer Fellows.
Several BSD graduate students and Pritzker medical students
have been lead authors on published papers. For example,
evolutionary biology graduate student Matt Friedman’s discov-
The new PhD program in biophysics began this fall with four
eries on the coelacanth fossil appeared in Evolution &
students who will work toward joint degrees from the Biological
Development, and fourth-year medical student Rachel Sherman,
Sciences and the Physical Sciences divisions. The program
whose finding that doctors believe placebos can have a
requires each student to team up with two labs and two
therapeutic effect, was detailed in the Journal of General
mentors, and will provide a path for graduate students to study
Internal Medicine.
interdisciplinary science. In addition, students in the program
will be “interface scholars”—part of the academic and research
community with opportunities to attend special seminars and
Biology student Matt Howard studies aquatic life, part of the hands-on
research facet of the University’s popular biodiversity class.
to travel—at HHMI, thanks to a grant of $1 million to start
the program and its continuing support of the University.
Another student, PhD candidate Rudy Faust, is the first
Chicago student to be part of HHMI’s Janelia Farm Research
Cooperative in Ashburn, Va. Faust is studying neuroscience at
the $500 million research campus, which is partnered with
the University of Chicago and Cambridge University. As
HHMI’s first freestanding campus, Janelia Farm provides a
The expertise of Professor Michael LaBarbera, PhD, is one of the reasons University of
Chicago students gain a sound knowledge of biology, essential for understanding many of
the most pressing problems of modern society.
24
setting in which small research groups can explore fundamental
2007 ANNUAL REPORT
25
David Meltzer, MD, PhD
Pritzker also has begun recognizing, and supporting with
grants, outstanding faculty members through the Academy of
Distinguished Medical Educators. This spring marked the
second time such teachers were recognized for their work in
medical education.
In addition to that recognition, the BSD has retooled the
tenure track, opening its doors for more faculty members to
strive for that professional accomplishment. Faculty on all
three BSD tracks—research scholars, clinical scholars and
clinician-educators—are eligible for tenure; previously, only
research scholars were on the tenure track. The new system
Bill McDade, MD, PhD, associate dean of multicultural affairs, works with underrepresented
minority undergraduate students in the Chicago Academic Medicine Program, or CAMP,
which offers a glimpse of medical school.
was developed after a committee recommended the changes
in 2004.
Doctors of Patient Care
This fall, the Department of Medicine added one more section
to its roster: Hospital Medicine. The new section, headed by
David Meltzer, MD, PhD, specializes in inpatient care. The
“hospitalist” concept, about 10 years old, has gained traction in
recent years, and Chicago has been hiring such physicians since
its inception.
General medicine doctors improve hospital patient care the
more they work in it, Meltzer said, but they are also more likely
to burn out if they devote too much of their time to hospital care.
The academic hospitalist program combines hospital care with
research, quality improvement and medical education to help
physicians establish sustainable careers that allow them to gain
substantial inpatient clinical experience without burning themselves out. Meltzer and his colleagues also developed the
Hospitalist Scholars Program to train practicing hospitalists in
research, education and quality improvement so they have the
tools needed to succeed.
The first students to complete the hospitalist program have
opted to stay with the University of Chicago after graduation,
rejecting job offers from Johns Hopkins and Northwestern, to
name a few. The combination of research, education and clinical
practice enticed them to stay.
Additionally, a $4 million grant from the Agency on Health
Care Research and Quality for research on hospital medicine,
pharmacogenetics and social networks for physicians will help
support research activities in this section.
Hospitalists who work at the Medical Center practice both here
and at Mercy Hospital, where some of Chicago’s emergency room
patients choose to register, often finding shorter wait times for
common ailments. A Medical Center attending is stationed daily
at Mercy, helping to provide exceptional health care with
neighboring partners of the University of Chicago.
26
The three tracks apply to different types of faculty work.
Research scholars, the traditional tenure track, spend the
bulk of their time conducting scholarship that is not directly
related to clinical care. Clinical scholars, by contrast, work
as both physicians and scholars, and often study human
subjects and disease. The third track, for clinician-educators,
is for faculty members active in clinical work, as well as
teaching or administration.
W ITH
SHIP,
A TRADITION OF INTERDISCIPLINARY SCHOLAR THE
UNIVERSITY
OF
CHICAGO
IS COMMITTED TO
INTELLECTUAL DISCOVERY THAT CHALLENGES STUDENTS
OF EXCEPTIONAL PROMISE TO BECOME LEADERS IN
SCIENCE AND MEDICINE.
Some learning focuses on finding and training students
before they arrive here—either as high school students or as
undergraduates. Two new programs are giving those younger
students a chance to get involved with research or education
at the University of Chicago.
The Chicago Academic Medicine Program offers underrepresented minority undergraduate students the chance to get a
taste of what medical school is like. And the Pritzker School of
Medicine Education in Research program gives college juniors
and seniors the opportunity to take part in an eight-week
research experience on campus. These programs developed
Kerstin Stenson, MD, (center) an expert on surgical treatment of head and neck cancers,
leads rounds in Mitchell Hospital with residents, medical students and nurses.
from existing ones that the Medical School continues to offer:
the Young Scientist Training Program and Training Early
Achievers for Careers in Health Research, both of which aim
to help students explore the field of medicine. ©
2007 ANNUAL REPORT
27
THE
“
PROCESS OF SCIENTIFIC DISCOVERY IS,
IN EFFECT, A CONTINUAL FLIGHT FROM WONDER.”
—Albert
SOMETIMES
Einstein
CHANGE BRINGS UNCERTAINTY.
BUT
IN THE EVOLUTION
OF SCIENCE AND MEDICINE, ONE THING SEEMS CERTAIN:
IF
OF
UNIVERSITY
MORE.
THE PAST YEAR HAS SEEN SIGNIFICANT CHANGES AT THE
CHICAGO,
ANTISEPTICS
THE YEARS TO COME WILL PRODUCE MANY
ANTIBIOTICS TOOK ANOTHER
TODAY,
1865;
PRACTICE.
DID NOT ARRIVE ON THE MEDICAL SCENE UNTIL
63
YEARS TO REACH CLINICAL
RESEARCH IN GENETICS MAKES POSSIBLE LEAPS FORWARD THAT
USED TO TAKE LIFETIMES .
THE
SPEED AT WHICH TECHNOLOGY AND
SCIENTIFIC RESEARCH ARE MOVING IS BLISTERING.
THE MEDICAL CENTER
DIVISION OF BIOLOGICAL SCIENCES
ARE WELL PREPARED TO WELCOME—AND TO EMBRACE—CHANGE. AN
INTERDISCIPLINARY SPIRIT, TOP-FLIGHT FACILITIES AND, MOST OF ALL,
SKILLED, DEDICATED AND CARING PEOPLE MAKE SUCH CHANGE POSSIBLE.
AND THE
PERHAPS CHANGE ISN’T THE ONLY CONSTANT IN SCIENCE AND MEDICINE.
AT THE UNIVERSITY OF CHICAGO MEDICAL CENTER, THERE IS ALSO
A WILLINGNESS TO ADAPT TO IT, TO LEARN FROM IT AND TO USE IT TO
IMPROVE PEOPLE’S LIVES.
28
2007 ANNUAL REPORT
29
FINANCIAL HIGHLIGHTS
AT
FINANCIAL REPORT 2007
A TIME OF CHALLENGE AND GREAT OPPORTUNITY FOR ACADEMIC MEDICINE,
WE ARE PROUD OF THE COMMITMENT, PROGRESS AND ACHIEVEMENTS MADE
UNIVERSITY OF CHICAGO MEDICAL CENTER AND THE BIOLOGICAL
SCIENCES DIVISION, BOTH FOR ITS PATIENT COMMUNITY AND TO SCIENCE.
LAST YEAR MARKED A BOLD, NEW BEGINNING FOR THE MEDICAL CENTER AS
WE CONSOLIDATED ALL OF THE UNIVERSITY’S PATIENT CARE ACTIVITIES UNDER
A SINGLE GOVERNANCE AND MANAGEMENT STRUCTURE. OUR HISTORICAL
STATEMENT OF REVENUES AND EXPENSES
DIVISION OF BIOLOGICAL SCIENCES
STATEMENT OF REVENUES AND EXPENSES
For the years ended June 30, 2007 and 2006 (in millions of dollars)
For the years ended June 30, 2007 and 2006 (in millions of dollars)
BY THE
COMMITMENT TO CARING FOR THOSE IN NEED DRIVES A POWERFUL FOCUS IN
STRATEGY: LEVERAGING OUR NEW STRUCTURE TO OPTIMIZE OUR DISTINCTION
RATHER THAN OUR SIZE, TO ENHANCE OUR PROGRAMMATIC AND FINANCIAL
Operating revenues
Compensation, supplies, services and other
Provision for doubtful accounts
2007
2006
1,122
953
Revenues
855
835
Tuition
56
44
Depreciation and interest
64
61
Medicaid Provider Tax
62
0
Operating expenses
1,037
940
Operating income
85
13
increase in revenues and applying the $4 million surplus generated
Investment income and unrestricted gifts, net
55
59
operating income up substantially, to $85 million in fiscal year
in 2006. Strong investment results and philanthropy drove an 18
Other, net
1
0
2007. A number of factors are responsible for this increase in
percent growth in net assets to $1.3 billion at year end.
Excess of revenues over expenses
STRENGTH RATHER THAN SIMPLE GROWTH.
This strategy has proven to be strong, driving Medical Center
income. First, although overall patient activity in the hospitals and
clinics increased by only about 1 percent, net revenues rose by
10 percent, reflecting a shift toward complex care for patients
drawn to the Medical Center from the entire region. New insurance contracts and continued improvement in the revenue cycle
also contributed. Additionally, two years of income from the
Illinois Medicaid provider tax program was received in 2007,
which included $18 million owed from 2006 but delayed due to
pending federal government approval. By comparison, operating
costs increased by less than 3 percent due to more effective
deployment of staff.
Financial strength is the key to planning an ambitious future, which
BALANCE SHEET
Health Initiative is a broad commitment to improve the health of
For June 30, 2007 and 2006 (in millions of dollars)
nearby residents by collaborating in meaningful ways with health
220
210
Endowment and gifts
67
59
183
176
15
15
Patient care
UCMC transfers for academic renewal
Other income
60
54
Total revenues
576
543
Faculty and other academic compensation
234
218
Grants and contracts
176
167
29
27
Expenses
Total expenses
250
186
Investments
732
612
nearly $82 million in charity care, measured at cost, for patients
Property, plant and equipment, net
533
497
covered by Medicaid or without insurance, with income from the
Other assets
38
26
2007 Illinois Medicaid provider tax program offsetting $18 million
Total assets
1,553
1,321
Current liabilities
196
189
Notes and accounts receivable
Long-term debt, less current maturities
395
364
Investments at market value
accounting adjustments to reflect more accurately the value of
excel in delivering primary and specialty care to a broad range of
Net assets
assets, contributed to the increase in net assets. Altogether net
patients. Through the Urban Health Initiative, the intent is to
Total liabilities and net assets
assets increased to $911 million by year end. The Medical Center
create a contemporary model that optimizes societal resources
continued its annual support of $15 million to the Biological
to deliver health care at the right places, at the right time.
The 2007 financial performance reflects enhanced coordination
539
-4
4
2007
2006
90
117
For June 30, 2007 and 2006 (in millions of dollars)
Cash and cash equivalents
recognizes that our partner healthcare providers in the community
127
BALANCE SHEET
of this amount. In a world of finite resources, the Medical Center’s
expertise continues to fill a need few others can—providing highly
141
580
Surplus generated (applied)
Current assets
Chicago’s South Side. Last year, the Medical Center provided
reduction in liabilities for general reserves, as well as other
Other liabilities
51
92
Total liabilities
642
645
911
676
1,553
1,321
PATIENT ACTIVITY
Land, buildings and equipment, net
Total assets
Current liabilities
Notes and bonds payable
58
52
982
780
433
382
1,563
1,331
33
32
229
196
Net assets
1,301
1,103
Total liabilities and net assets
1,563
1,331
For the years ended June 30, 2007 and 2006
among all of the components of the biomedical enterprise. We are
focused on supplying the complex care that is most suited to an
Admissions
academic medical center, while also linking to a larger network of
Patient days
percent to $580 million, representing continued investment in
community-based providers. On this basis, the Medical Center
Length of stay
biomedical faculty, graduate and medical education, and ground-
and the Biological Sciences Division are securing the capital
DCAM visits
breaking research, including the first full year of operations for
required for significant investment in new facilities, technology
ER visits
the Gordon Center for Integrative Science. This infusion of resources
and programs that deliver on our missions and are among the
into our academic programs was supported through a 6 percent
finest in the nation.
30 UNIVERSITY OF CHICAGO MEDICAL CENTER
Grants and contracts
2006
educating future physicians and scientists. The Medical Center
The budget of the Biological Sciences Division increased by 7
29
2007
care providers and organizations throughout the neighborhoods on
million and unrealized gains of $49 million. A $35 million
Medical Center’s market position “At the Forefront of Medicine.”
31
Facilities and other expenses
includes as a top priority the Urban Health Initiative. The Urban
specialized medical care, conducting biomedical research and
in the basic biological and clinical sciences that underpin the
72
2006
Financial aid
Investments also performed well, with investment income of $55
Sciences Division for the Academic Renewal Fund, which invests
141
2007
2007
2006
26,377
26,933
165,914 174,995
6.29
6.50
402,355 394,720
85,092
79,534
2007 ANNUAL REPORT
31
THE UNIVERSITY OF CHICAGO MEDICAL CENTER
DIVISION OF THE BIOLOGICAL SCIENCES &
PRITZKER SCHOOL OF MEDICINE
MEDICAL CENTER BOARD
TRUSTEES
OFFICERS
LEADERSHIP
Valerie B. Jarrett, Chair
Nicholas K. Pontikes
Paul F. Anderson
James Reynolds, Jr.
Robert H. Bergman
Thomas A. Reynolds III
MAYA BORDEAUX (Interim)
Vice President and Chief
Human Resources Officer
Edward McC. Blair, Jr.
Thomas F. Rosenbaum (ex officio)
Ellen Block
Jeffrey T. Sheffield
Otis W. Brawley, MD
Jorge A. Solis
Deborah A. Bricker
John A. Svoboda
JAMES L. MADARA, MD
CEO, University of Chicago
Medical Center
Sara and Harold Lincoln Thompson
Distinguished Service Professor
Dean, Division of the Biological
Sciences and Pritzker School of Medicine
University Vice President for Medical
Affairs
Kevin J. Brown
Michael Tang
John Bucksbaum
Christina M. Tchen
Frank M. Clark
J. Richard Thistlethwaite, MD
(ex officio)
James S. Crown (ex officio)
Allison S. Davis
Craig J. Duchossois
James S. Frank
Stanford J. Goldblatt
Rodney L. Goldstein
Linda H. Heagy
David S. Hefner (ex officio)
OF
MarrGwen Townsend
LAWRENCE J. FURNSTAHL
Chief Financial and Strategy Officer
Treasurer
MAYUMI FUKUI
Vice President for Managed Care and
Program Development
MEDICAL STAFF
ORGANIZATION
Paula Wolff
Robert J. Zimmer (ex officio)
William J. Hunckler III
J. RICHARD THISTLETHWAITE, MD, PhD
President
STEPHEN G. WEBER, MD, MS
Vice President
Jeffrey D. Jacobs
Kenneth Lehman
JEFFREY A. FINESILVER
Vice President and Director,
Comer Children’s Hospital
Terry L. Van Der Aa
Bruce W. White
LIFE TRUSTEES
Carol Levy
Marshall Bennett
Barry L. MacLean
Lindy Bergman
James L. Madara, MD (ex officio)
Sidney Epstein
Cheryl Mayberry-McKissack
Robert Feitler
Dane A. Miller
Jules F. Knapp
Ralph G. Moore
Howard G. Krane
Christopher J. Murphy III
John D. Mabie
Emily Nicklin
Marjorie I. Mitchell
Brien M. O’Brien
Michael Rosenberg
Timothy K. Ozark
Robert G. Schloerb
Robert G. Weiss
MARTIN FEDER, PhD
Faculty Dean of Academic Affairs
DAVID S. HEFNER
Medical Center President
James C. Tyree
Kelly R. Welsh
THOMAS CUTTER, MD
Medical Director of Perioperative Services
P. ALLAN KLOCK, JR., MD
Secretary
HARVEY GOLOMB, MD
Dean of Clinical Affairs
Chief Medical Officer
D. ALLAN GRAY
Vice President for Perioperative Services
DAVID HICKS
Chief Pharmacy Officer
DAVID HO
Vice President for Finance
SANDRA CULBERTSON, MD
Councilor
HOLLY HUMPHREY
Dean of Medical Education
Chair, Education Committee
FRED OVSIEW, MD
Councilor
VICKIE L. HUMPHREY
Vice President for Support Services
BRUCE MINSKY, MD
Associate Dean for Clinical Quality
Chief Quality Officer
MICHELLE R. OBAMA
Vice President for Community
and External Affairs
JAMIE M. O’MALLEY
Vice President and
Chief Nursing Officer, Patient Services
JOSÉ QUINTANS, MD, PhD
Associate Dean and Master,
Biological Sciences Collegiate Division
MICHELE SCHIELE
Associate Dean and Vice President
for Development
NANCY SCHWARTZ, PhD
Dean of Graduate Affairs
ANN SCHWIND
Associate Dean for Administration
SANDRA SENTI
Chief Information Officer
SUSAN S. SHER
Vice President for Legal and Governmental Affairs
General Counsel
NEIL SHUBIN, PhD
Associate Dean for Organismal and
Evolutionary Biology
Provost of the Field Museum
JULIAN SOLWAY, MD
Associate Dean for Translational Medicine
WALTER STADLER, MD
Associate Dean of Clinical Research
KELLY M. SULLIVAN
Vice President for Communications and Marketing
MARK A. URQUHART
Vice President for Facilities, Design and
Construction
ERIC WHITAKER, MD, MPH
Executive Vice President of Strategic Affiliations
Associate Dean for Community-Based Research
CAROLYN WILSON
Associate Dean and Vice President for Faculty
Practice Administration
ERIC B. YABLONKA
Vice President and Chief Information Officer
ANESTHESIA AND CRITICAL CARE
Jeffrey Apfelbaum, MD
MEDICINE
Joe G.N. Garcia, MD
ORGANISMAL BIOLOGY AND ANATOMY
Jan-Marino Ramirez, PhD
BEN MAY DEPARTMENT FOR CANCER
RESEARCH
Marsha Rosner, PhD
MICROBIOLOGY
Olaf Schneewind, MD, PhD
PATHOLOGY
Vinay Kumar, MD
MOLECULAR GENETICS AND CELL BIOLOGY
Richard Fehon, PhD
PEDIATRICS
Michael Schreiber, MD (Acting)
NEUROBIOLOGY
S. Murray Sherman, PhD
PSYCHIATRY
Emil Coccaro, MD
NEUROLOGY
Christopher Gomez, MD, PhD
RADIATION AND CELLULAR ONCOLOGY
Ralph Weichselbaum, MD
OBSTETRICS AND GYNECOLOGY
Arthur Haney, MD
RADIOLOGY
Richard Baron, MD
OPHTHALMOLOGY AND VISUAL SCIENCES
William Mieler, MD
SURGERY
Jeffrey Matthews, MD
ECOLOGY AND EVOLUTION
Joy Bergelson, PhD
FAMILY MEDICINE
Bernard Ewigman, MD, MPH
HEALTH STUDIES
Ronald Thisted, PhD
HUMAN GENETICS
T. Conrad Gilliam, PhD
VINAY KUMAR, MD
Executive Vice Dean
Chair of Pathology
KENNETH SHARIGIAN
Associate Dean and Vice President for
Organizational Strategy and Planning
DEPARTMENT CHAIRS
BIOCHEMISTRY AND MOLECULAR BIOLOGY
Anthony Kossiakoff, PhD
32
MICHAEL J. KOETTING
Vice President for Planning
2007 ANNUAL REPORT
33
DIVISIONAL OVERSIGHT
AND GOVERNANCE
EXECUTIVE COMMITTEE
CLINICAL CHAIRS COMMITTEE
RESEARCH ADVISORY COMMITTEE
James Madara, UCMC Executive Office, Chair
Holly Humphrey, Medical Education
Olaf Schneewind, Microbiology
Jeffery Apfelbaum, Anesthesia and Critical Care
Vinay Kumar, Pathology, Chair
Jeffrey Apfelbaum, Anesthesia and Critical Care
David Jablonski, Evolutionary Biology
Michael Schreiber, Pediatrics
Richard Baron, Radiology
Joe Garcia, Medicine
Richard Baron, Radiology
Stephen Kent, Institute for Biophysical Dynamics
Emil Coccaro, Psychiatry
T. Conrad Gilliam, Human Genetics
Albert Bendelac, Immunology
Bernard Ewigman, Family Medicine
Christopher Gomez, Neurology
Joy Bergelson, Ecology and Evolution
Anthony Kossiakoff, Biochemistry and
Molecular Biology
Eric Schwartz, Neurobiology, Pharmacology
and Physiology
Jeffery Matthews, Surgery
Eric Beyer, Cell Physiology
Vinay Kumar, Pathology
Nancy Schwartz, Graduate Affairs and
Kennedy Center
Jan-Marino Ramirez, Organismal Biology and Anatomy
Douglas Bishop, Genetics
Michelle Le Beau, Cancer Research Center
Ann Schwind, UCMC Executive Office
Marsha Rosner, Ben May Department for Cancer Research
Emil Coccaro, Psychiatry
Peggy Mason, Committee on Neurobiology
Michele Seidl, UCMC Executive Office
Arthur Haney, Obstetrics and Gynecology
David Hefner, UCMC Executive Office
Michele Seidl, UCMC Executive Office (ex officio)
Kenneth Sharigian, UCMC Executive Office
Bernard Ewigman, Family Medicine
Kenneth Sharigian, UCMC Executive Office (ex officio)
Martin Feder, Academic Affairs
Elizabeth McNally, Institute for
Cardiovascular Research
S. Murray Sherman, Neurobiology
Holly Humphrey, UCMC Executive Office
Vinay Kumar, UCMC Executive Office and Pathology
Neil Shubin, Organismal and Evolutionary Biology
Richard Fehon, Molecular Genetics and
Cell Biology
Lawrence Furnstahl, UCMC Executive Office
Maryellen Giger, Medical Physics
Harvey Golomb, UCMC Executive Office
Geoffrey Greene, Cancer Biology
Arthur Haney, Obstetrics and Gynecology
David Hefner, UCMC Executive Office
William Mieler, Ophthalmology and Visual
Science
Julian Solway, Translational Research
Victoria Prince, Developmental Biology
Ronald Thisted, Health Studies
José Quintans, Collegiate Division
J. Richard Thistlethwaite, Medical Staff Office
Jan-Marino Ramirez, Organismal Biology
and Anatomy
Philip Ulinski, Computational Neuroscience
Mark Ratain, Clinical Pharmacology and
Pharmacogenomics
Marsha Rosner, Ben May Department for
Cancer Research
Walter Stadler, Clinical Research
Carolyn Wilson, UCMC Executive Office
Michele Schiele, Development
Holly Humphrey, Chair
Joy Bergelson, Ecology and Evolution
Ann Schwind (ex officio)
Kenneth Sharigian (ex officio)
Neil Shubin
Richard Fehon, Molecular Genetics and Cell Biology
Anthony Kossiakoff, Biochemistry and Molecular Biology
Vinay Kumar, UCMC Executive Office and Pathology
Jan-Marino Ramirez, Organismal Biology and Anatomy
Marsha Rosner, Ben May Department for Cancer Research
Olaf Schneewind, Microbiology
Eric Schwartz, Neurobiology, Pharmacology and Physiology
Michele Seidl, UCMC Executive Office
S. Murray Sherman, Neurobiology
Ronald Thisted, Health Studies
34
Michael Schreiber, Pediatrics
Ralph Weichselbaum, Radiation and Cellular Oncology
Carolyn Wilson, UCMC Executive Office
Roy Weiss, Clinical Research Center
BASIC SCIENCE CHAIRS COMMITTEE
Nancy Schwartz
William Mieler, Ophthalmology and Visual Science
Ralph Weichselbaum, Radiation and Cellular
Oncology
EDUCATION COMMITTEE
José Quintans
BSD VISITING COMMITTEE
M. Roy Schwarz, Co-Chair
Janice Katz
Trisha Rooney Alden
Douglass B. Given, Co-Chair
Elliott Kieff
Paul S. Russell
Christopher Alafi
Gwen Knapp
Catherine Ryan
Diane Patricia Atwood
Victoria Mitchell Kohn
David R. Schwartz
Douglas S. Basler
H. Jonathan Kovler
Carole Segal
Matthew Bucksbaum
Kenneth L. Kummer
John B. Snyder
Jordan J. Cohen
Mitchell Lederer
James A. Star
Marvin Conney
John D. Mabie
James Stephen
Mildred Conney
Mary Ann MacLean
John Svoboda
Kim Duchossois
Roland V. McPherson
Paul Talalay
Christopher S. Eklund
Rosemarie Mitchell
Laura Thrall
James S. Frank
Thomas L. Mitchell
Daniel C. Tosteson
L. Patrick Gage
Steven Nakovich
Scott Wald
Ellen R. Gordon
Timothy K. Ozark
Elizabeth White
Robert G. Hershenhorn
Charles Palmer
David Whitney
Hollye Harrington Jacobs
Charles Polsky
Joan T. Zajtchuk
David Kalt
Thomas A. Reynolds III
Russ Zajtchuk
Attallah Kappas
Theodore H. Roberts
Laurence Zung
David Katz
Paul G. Rogers
2007 ANNUAL REPORT
35
THE UNIVERSITY OF CHICAGO
DIVISION OF THE BIOLOGICAL SCIENCES
2006-2007 RECRUITMENT AND PROMOTIONS
RECRUITMENT
PROMOTIONS
ANESTHESIA & CRITICAL CARE
Frank Dupont, Assistant Professor
Ori Gottlieb, Assistant Professor
Michael Hernandez, Assistant Professor
Igor Tkachenko, Assistant Professor
BEN MAY DEPARTMENT
CANCER RESEARCH
FOR
Richard Jones, Assistant Professor
HEALTH STUDIES
Habibul Ahsan, Professor
Tyler Vanderweele, Assistant Professor
HUMAN GENETICS
Nanduri Prabhakar, Professor
James Rhee, Assistant Professor
Christopher Rhodes, Professor
Rita Rossi-Foulkes, Assistant Professor
Andrey Rzhetsky, Professor
Aisha Sethi, Assistant Professor
Patrick Singleton, Instructor
Andrew Skol, Instructor
Nilam Soni, Instructor
Maria Tsoukas, Assistant Professor
Kaveeta Vasisht, Instructor
Roopa Vemulapalli, Instructor
Victoria Villaflor, Assistant Professor
Barton Wicksteed, Assistant Professor
John Cunningham, Professor
Ronald Espinal, Instructor
Heather Fagan, Instructor
Jeffrey Gossett, Instructor
Daniel Johnson, Associate Professor
Heather Johnston, Instructor
Ivan Moskowitz, Assistant Professor
Adriana Orozco-Kellermeier, Instructor
Timothy Sentongo, Assistant Professor
Mala Setty, Instructor
Kelley Staley, Instructor
Wim Van Drongelen, Assistant Professor
Rachel Wolfson, Instructor
Christine Yu, Instructor
NEUROBIOLOGY
PSYCHIATRY
Jason MacLean, Assistant Professor
Constance (Tina) Drossos, Instructor
Peter Nierman, Assistant Professor
Lisa Sanchez-Johnson, Assistant Professor
Marie Tobin, Associate Professor
Shona Vas, Assistant Professor
Kevin White, Professor
MEDICINE
Steven Archer, Professor
Sameer Badlani, Instructor
George Bakris, Professor
Nisha Bansal, Instructor
George Bell, Instructor
John Beshai, Assistant Professor
Kristine Bordenave, Assistant Professor
Rebecca Brown, Instructor
Keme Carter, Assistant Professor
Suma Dronavalli, Instructor
Thomas Fisher, Instructor
Caroline Harada, Instructor
Keiki Hinami, Instructor
James Holaska, Assistant Professor
Haochu Huang, Assistant Professor
Susan Kim, Assistant Professor
Rick Kittles, Associate Professor
Jerry Krishnan, Associate Professor
Ratneshwar Lal, Professor
Gregory Lam, Instructor
Tanguy Lim-Seiwert, Instructor
Michael Maitland, Instructor
Rupa Mehta, Assistant Professor
Babak Mokhlesi, Assistant Professor
Dan Nicolae, Associate Professor
Anne O'Connor, Assistant Professor
Monica Peek, Assistant Professor
Minoli Perera, Instructor
Blase Polite, Instructor
36
NEUROLOGY
John Jacobsen, Assistant Professor
Adil Javed, Assistant Professor
Daniel Llano, Instructor
OBSTETRICS & GYNECOLOGY
Susan Fee, Associate Professor
Sabrina Holmquist, Assistant Professor
Natasha Jenkins, Instructor
Sarah Temkin, Assistant Professor
Mishka Terplan, Assistant Professor
OPHTHALMOLOGY &
VISUAL SCIENCE
Michael Grassi, Assistant Professor
Ana Loduca, Assistant Professor
PATHOLOGY
Hikmat Al-Ahmadie, Assistant Professor
Elizabeth Hyjek, Assistant Professor
Jeffrey Mueller, Instructor
Husain Sattar, Instructor
PEDIATRICS
Martin Bazi, Instructor
Edith Chernoff, Assistant Professor
Susan Cohn, Professor
Rena Conti, Instructor
RADIATION &
CELLULAR ONCOLOGY
Stanley Liauw, Instructor
Bruce Minsky, Professor
Joseph Salama, Instructor
RADIOLOGY
Paul Chang, Professor
Aytekin Oto, Associate Professor
Kenji Suzuki, Assistant Professor
SURGERY
Peter Angelos, Professor
Robert Bielski, Assistant Professor
Kathleen Goss, Assistant Professor
Mahesh Gupta, Associate Professor
Ginard Henry, Assistant Professor
Hue Luu, Assistant Professor
Karl Matlin, Professor
Jeffrey Matthews, Professor
Russell Reid, Assistant Professor
Martin ter Beest, Assistant Professor
Mirjam Zegers, Assistant Professor
BEN MAY DEPARTMENT
CANCER RESEARCH
FOR
ORGANISMAL BIOLOGY
& ANATOMY
Anning Lin, Professor
Robert Ho, Professor
BIOCHEMISTRY &
MOLECULAR BIOLOGY
PATHOLOGY
Tobin Sosnick, Professor
Anthony Chang, Assistant Professor
Anthony Montag, Professor
HUMAN GENETICS
PEDIATRICS
Bruce Lahn, Professor
Holly Benjamin, Associate Professor
Maria Dowell, Assistant Professor
Mark Hostetler, Associate Professor
Peter Koenig, Associate Professor
Tracy Koogler, Associate Professor
Poj Lysouvakon, Assistant Professor
Cathy Mavrolas, Associate Professor
Swarupa Nimmagadda, Assistant Professor
Tamara Nix, Assistant Professor
Helaine Ross, Professor
MEDICINE
Marisa Alegre, Associate Professor
Vineet Arora, Assistant Professor
Anirban Basu, Assistant Professor
Saima Chohan, Assistant Professor
K. Douglas Hogarth, Assistant Professor
Michelle Josephson, Professor
Ann Mauer, Associate Professor
Patrick Murray, Professor
Elaine Petrof, Assistant Professor
K. Gautham Reddy, Assistant Professor
Daniel Spergel, Assistant Professor
Walter Stadler, Professor
Esra Tasali, Assistant Professor
Janis Tupesis, Assistant Professor
Tammy Utset, Associate Professor
Monica Vela, Assistant Professor
Chad Whelan, Associate Professor
Amittha Wickrema, Associate Professor
Tracie Wilcox, Assistant Professor
Todd Zimmerman, Associate Professor
MOLECULAR GENETICS
& CELL BIOLOGY
Jocelyn Malamy, Associate Professor
NEUROLOGY
Maria Baldwin, Assistant Professor
PSYCHIATRY
Harriet de Wit, Professor
RADIATION &
CELLULAR ONCOLOGY
Bulent Aydogan, Assistant Professor
Steven Chmura, Assistant Professor
RADIOLOGY
Samuel Armato, Associate Professor
Yulei Jiang, Associate Professor
Gillian Newstead, Professor
Mario Zaritzky, Assistant Professor
SURGERY
Tong-Chuan He, Associate Professor
Donald Liu, Professor
Arieh Shalhav, Professor
Mindy Statter, Associate Professor
Dana Suskind, Associate Professor
OBSTETRICS & GYNECOLOGY
Stuart Slaw, Assistant Professor
S. Diane Yamada, Associate Professor
2007 ANNUAL REPORT
37
FEDERAL GRANTS
Abe, Mark, Pediatrics
National Heart, Lung, and Blood Institute
“Characterization of a ERK8, a New MAPK
in Lung”
Bergelson, Joy, E&E
National Science Foundation
“Forces Shaping Microbial Communities in the
Phyllosphere of Arabidopsis thaliana”
Brorson, James, Neurology
National Inst. of Neurological Disorders and Stroke
“AMPA Receptor Expression and Selective
Neuronal Death”
Abney, Mark A., Human Genetics
National Center For Human Genome Research
“Methods for Complex Trait Mapping in
Large Pedigrees”
Bergelson, Joy, E&E
National Institute of General Medical Sciences
“Evolutionary Genetics of R Loci in Arabidopsis”
Burnet, Deborah, Medicine
Nat. Inst. of Diabetes and Digestive and
Kidney Diseases
“Reach Out Chicago Children’s Diabetes
Prevention Project”
Adams, Erin J., BMB
National Institutes of Health
“Molecular Recognition of Ligand by the
Gamma Delta T Cell Receptor”
Alegre, Maria-Luisa, Medicine
National Institute of Allergy and
Infectious Diseases
“Role of NF-kB Activation in Acute
Allograft Rejection”
Alexander, Caleb, Medicine
Agency for Healthcare Research and Quality
“A Randomized Controlled Trial (RCT) to
Decrease Out-of-Pocket Prescription Costs”
Alexander, Kenneth, Pediatrics
National Cancer Institute
“Anti-HPV RNA Interference Using
Modified RNAs”
Alverdy, John, Surgery
“Pseudomonas Effects on the Gut Barrier
from Surgery”
Anderson, Allen, Medicine
“Treatment of Preserved Cardiac Function
Heart Failure with an Aldosterone
Antagonist (TOPCAT)”
Bergelson, Joy, E&E
“The Pattern of Polymorphism in
Arabidopsis thaliana”
Cohn, Susan, Pediatrics
“Children’s Oncology Group Chair Award”
Cohn, Susan L., Pediatrics
“National Childhood Cancer Foundation for the
Children’s Oncology Group”
Daugherty, Christopher, Medicine
“Ethics and Clinical Trials in Advanced
Cancer Care”
Daum, Robert S., Pediatrics
National Institute of Allergy and Infectious
Diseases
“Spread of Community-Acquired MRSA
Among Household Contacts”
Beyer, Eric C., Pediatrics
“Connexons in Cardiovascular
Cell Communication”
Cagney, Kathleen A., Health Studies
National Institute on Aging
“Neighborhood Context and the Health
of Older Adults”
Chong, Anita S., Surgery
Kidney Diseases
“Spleen Regulation of Beta-Cell Regeneration”
Cohn, Susan L., Pediatrics
“NANT (New Approaches to Neuroblastoma
Therapy) Consortium”
Bezanilla, Francisco, Pediatrics
“Electrophysiological Studies of Voltage
Gated Channels”
Cagney, Kathleen A., Health Studies
“Socioeconomic Status (SES) and Age-Related
Disability in a Biracial Community”
Infectious Diseases
“Stem Cells for Tolerance Induction”
Conzen, Suzanne D., Medicine
“Glucocorticoid Receptor-Mediated Survival
Signaling in Breast Cancer”
Bezanilla, Francisco, Pediatrics
National Institute on Mental Health
“Surface Plasmon-Coupled Flourescence
Microscope to Study Ion Channel Dynamics”
Cai, Hua, Medicine
“Angiotensin II Uncoupling of eNOS
in Hypertension”
Christian, Susan L., Human Genetics
National Inst. of Neurological Disorders
and Stroke
“Genomic Imbalances in Autism”
Correa, Ana Maria, Pediatrics
“Voltage-Gating in Bacterial Ion Channels”
Birukov, Konstantin, Medicine
“Mechanochemical Regulation of
Endothelial Permeability”
Cai, Hua, Medicine
“Endocardial Dysfunction in Humans with
Atrial Fibrillation”
Clark, Marcus Ramsay, Medicine
“B Cell Receptor Regulation of Antigen
Processing”
Birukov, Konstantin, Medicine
“Control of Lung Permeability by
Oxidized Phospholipids”
Chang, Eugene B., Medicine
Kidney Diseases
“Inflammatory Bowel Disease (IBD) and
Mucosal Inflammation, Immunology, and
Microbiology of the GI Tract”
Clark, Marcus Ramsay, Medicine
“Relationships Between B Cell Antigen
Receptor Signaling and Endocytosis”
Cox, Nancy Jean, Medicine
“Genome-Wide Association Mapping of
Metabolic, Lung and Cardiovascular
Phenotypes”
Claud, Erika C., Pediatrics
National Institute of Child Health
and Human Development
“Regulation of Inflammation in Immature
Intestine”
Nat. Inst. of Diabetes and Digestive and Kidney
Diseases
“Copy-Number Polymorphism Analysis of the
Type-2 Diabetes Gene Calpain 10”
Coates, Michael I., Evol Biology
Environmental Protection Agency
“Loss, Generation and Maintenance of
Ecomorphological Diversity in Marine Teleost
Fishes: Deep Time Perspectives on
Contemporary Biodiversity Basis”
National Institute on Deafness and Other
Communication Disorders
“Identification of Sex-Specific Genes for
Stuttering”
Bishop, Douglas K., Rad Onc
“Genetic Dissection of BRCA1’s
Recombination Function”
Bassiouny, Hisham, Surgery
and Stroke
“MR Determination of Carotid
Atherosclerosis Progression”
Bissonnette, Bruce, Medicine
“Roles of ErbB Signaling in
Colonic Carcinogenesis”
Boone, David, Medicine
Kidney Diseases
“Regulation of TLR Signals and IBD by A20”
Borevitz, Justin, E&E
“Genome Wide Association Mapping in
Arabidopsis thaliana”
Brady, Matthew J., Medicine
Kidney Diseases
“Role of PTG in Adipocytic Glycogen Metabolism”
Bray, Elizabeth, MGCB
Department of Energy
“Molecular-Genetic Analysis of Osmoregulation,
Osmotic Adjustment and Growth in Arabidopsis”
Kidney Diseases
“Research Training in Digestive Diseases
and Nutrition”
Kidney Diseases
“Role and Regulation of Intestinal
Na/H Exchangers”
Kidney Diseases
“Cytoprotective Role of Heat Shock Proteins
in IBD”
Chervonsky, Alexander V., Pathology
Kidney Diseases
“Genetic Control of Homing of Autoimmune
T Cells”
Chervonsky, Alexander V., Pathology
Diseases
“Fas in Host Defense and Autoimmune
Diseases”
Coccaro, Emil F., Psychiatry
“Impulsive Aggression: A Twin Study of
Behavior and 5-HT”
“Fluoxetine and Divalproex: Treatment
Correlates in Intermittent Explosive
Disorder (IED)”
“Social Information Processing: Assessment
Development”
Coe, Fredric L., Medicine
Diseases
“Pathogenesis of Calcium Nephrolithiasis”
Dalvi, Arif, Neurology
National Inst. of Neurological Disorders and
Stroke
“POSTCEPT: A Longitudinal Observational
Follow-up of the PRECEPT Study Cohort”
Dalvi, Arif, Neurology
National Inst. of Neurological Disorders and
Stroke
“PROGENI: Parkinson’s Disease Collaborative
Study of Genetic Linkage”
Beyer, Eric C., Pediatrics
National Eye Institute
“Biology of Lens Intercellular Communication”
Bakris, George, Medicine
Kidney Diseases
“AASK Cohort Study”
Bendelac, Albert, Ben May Dept Can Res
Infectious Diseases
“Interdisciplinary Training Program
in Immunology”
Cohen, Ronald N., Medicine
“Role of SMRT and NCoR in Adipocyte
Differentiation and Function”
Diseases
“Graft Rejection and Accommodation by
Anti-Gal mABs”
Bishop, Douglas K., Rad Onc
“Meiotic Interactions of the RecA
Homologue Dmc1”
Bendelac, Albert, Pathology
Infectious Diseases
“Glycolipid Presentation by CD1d”
Cho, Judy, Medicine
Kidney Diseases
“IBD Consortium Genetics Research Center”
Cohen, Ronald N., Medicine
“Recruitment of Corepressors in the Adipocyte”
Burnet, Deborah, Pediatrics
Kidney Diseases
“Reducing Type-2 Diabetes Risk in
African-American Youth”
Armato, Samuel G., Radiology
“Computerized Analysis of Mesothelioma on
Computed Tomography (CT) Scans”
Bell, Graeme, Medicine
Kidney Diseases
“Diabetes Research Training Center”
Cho, Judy, Medicine
Kidney Diseases
“IBD Genetics Consortium Data Coordinating
Center”
“Genome-Wide Association for Asthma and
Lung Function”
Coyne, Jerry, E&E
“Genetic Basis of Species Differentiation in
Drosophila”
Crispino, John D., Ben May Dept Can Res
“Mechanisms of Leukemogenesis in
Down Syndrome”
Curlin, Farr A., Medicine
National Center for Complementary and
Alternative Medicine
“Religious Commitments and Clinical
Engagements”
Dale, William, Medicine
“Emotions in Medical Decision-Making
in Older Adults”
Daum, Robert S., Pediatrics
Centers for Disease Control
“MRSA Colonization and Control in the Cook
County Jail”
Dawson, Glyn, Pediatrics
and Stroke
“Glycosphingolipid Metabolism and Mental
Retardation”
De Wit, Harriet, Psychiatry
National Institute on Drug Abuse
“Drug Abuse and Impulsivity: Human
Laboratory Models”
De Wit, Harriet, Psychiatry
“Craving During Smoking Abstinence:
Does It Abate or Incubate?”
Deplewski, Dianne, Pediatrics
Diseases
“Role of PPAR Gamma Amino-Terminus
in the Adipocyte”
Di Rienzo, Anna, Human Genetics
Diseases
“Evolutionary Genetics of the
Metabolic Syndrome”
Di Rienzo, Anna, Human Genetics
“Local Adaptations in Humans”
Dignam, James J., Health Studies
“An Investigation of Approaches to
Estimating Cause-Specific Survival After
Early Stage Cancer”
Doi, Kunio, Radiology
“CAD for CT Nodules in Lung Cancer
Detection”
Dolan, Mary Eileen, Medicine
“Role of DNA Repair in Protecting Against
Secondary Leukemias”
2007 ANNUAL REPORT
39
Dolan, Mary Eileen, Medicine
“Pharmacology of Cyclophosphamide
and Other Alkylators”
Fichera, Alessandro, Surgery
“Timing of Rectal Cancer Response to
Chemoradiation”
Gao, Jia-Hong, Radiology
National Center for Research Resources
“3T MRI Scanner for High Resolution
MRI/MRIS Research”
Giger, Maryellen L., Radiology
“Optimization of Computer-Aided Diagnosis
(CAD) Output in Breast Imaging”
Du, Wei, Ben May Dept Can Res
“Control of Cell Proliferation and Differentiation
in the Developing Retina”
Fleming, Gini, Medicine
“Cancer and Leukemia Group B”
National Institute of Biological Imaging
and Bioengineering
“Development and Optimization of Magnetic
Source MRI”
Army Research Office
“Correlative Feature Analysis for
Multi-Modality Breast CAD”
Dudek, Steven, Medicine
“Cortactin in Regulation of Pulmonary Vascular
Permeability”
Dudek, Steven, Medicine
“Endothelial Cell Cytoskeletal Regulation
by Cortactin”
Dulawa, Stephanie, Psychiatry
“Mechanisms for 5-HTT Control of PPI and
Perseverative Behavior Using Mouse Models”
Dulawa, Stephanie, Psychiatry
“Mechanism of the Antidepressant Response
in 5-Ht1Ar Mice”
Dulin, Nickolai, Medicine
“Activation of Protein Kinase A
by Endothelin-1”
Dwyer, Gregory, E&E
“Mechanisms of Disease Transmission
Variability in Host Susceptibility and Forest
Defoliator Outbreaks”
Ehrmann, David A., Medicine
“Sleep, Metabolic, and Cardiovascular
Dysfunction in Polycystic Ovarian
Syndrome (PCOS)”
Ehrmann, David A., Medicine
Nat. Inst. of Diabetes and Digestive
and Kidney Diseases
“Post-Diabetes Prevention Program”
Ewigman, Bernard G., Family Medicine
Health Resources and Services Administration
“Faculty Development in Prime Care”
Feder, Martin, Organ Bio and Anatomy
“Ecological and Evolutionary Physiology of
Stress Response and Stress Proteins”
Fehon, Richard G., MGCB
and Stroke
“Function of Merlin, a Drosophila NF2
Gene Homologue”
Fehon, Richard G., MGCB
“Functions of the Epithelial Septate Junction”
Ferguson, Edwin L., MGCB
“Establishment of DPP Activity Gradient in
Drosophila”
Fleming, Gini, Medicine
“Gynecologic Oncology Group Developmental
Therapeutics Committee: Chair/Co-Chair”
Foster, Ian, Instr/Research
“Architecture Work Group Participation”
Office of Naval Research
“MRI of Current Density and Current
Pathways Study”
Foster, Ian, Instr/Research
“Architecture Work Group Participation”
Garcia, Joe G.N., Medicine
“Cytoskeletal Regulation of Lung Endothelial
Pathobiology”
Fozzard, Harry A., Medicine
“Structure-Function of the Cardiac Sodium
Channel”
“Ventilator-Associated Lung Injury:
Molecular Approaches”
Franzoso, Guido, Ben May Dept Can Res
“The NF-kB Target Gadd45B in Lymphocytes
and Liver”
“Particulate Matter Research Center
(Toxicity Project)”
Franzoso, Guido Ben May Dept Can Res
“Roles of Gadd45-beta in JNK Signaling,
Apoptosis, and Cancer”
“Pulmonary Hypertension and the Hypoxic
Response in Sudden Cardiac Death (SCD)”
Frim, David M., Surgery
and Stroke
“Hydrocephalus, Intracranial Pressure, and
Neurocognition”
“Endothelial Cell Phenotypes in Health
and Disease”
Fu, Yang-Xin, Pathology
Infectious Diseases
“The Development and Function of
Lymphoid Tissues”
“The Role of IgE in Airway Inflammation”
and Kidney Diseases
“The Role of Lymphoid Microenvironment
in Autoimmunity”
“Enhanced Immunity Inside of Tumor
Microenvironment”
Gajewski, Thomas F., Pathology
“Countering Immune Resistance in the
Melanoma Tumor Microenvironment”
Gajewski, Thomas F., Pathology
“T Cell Responsiveness and Homeostasis
in Anti-Tumor”
Gershon, Elliot S., Psychiatry
“Fine Genomic Mapping of 13q32
in Bipolar Disorder”
“A Collaborative Genetic Study of
Bipolar Disorder”
“Multidisciplinary Psychiatric Genetics
Training Program”
Getz, Godfrey S., Pathology
“Lymphotoxin/LIGHT in Lipoprotein Metabolism
and Atherosclerosis”
Getz, Godfrey S., Pathology
“ApoA1 Determining HDL Subclasses and
Atherosclerosis”
and Bioengineering
“Research Training in Medical Physics”
National Institute of Arthritis and
Musculoskeletal and Skin Diseases
“Computerized Radiographic Analysis of Bone
Structure”
Gilad, Yoav, Human Genetics
“Natural Selection on Gene Regulation
in Humans”
Gilliam, T. Conrad, Human Genetics
“Genetics of Common Heritable Disorders
in Venezuela”
Gilliam, T. Conrad, Human Genetics
“National Center for the Study of
Cellular Networks”
Gomez, Christopher M., Neurology
and Stroke
“Acetylcholine Receptor Genes in
Slow-Channel Syndrome”
Gornicki, Piotr, MGCB
Department of Agriculture
“International Wheat Genome Sequencing
Consortium: A Physical Map and Sample
Sequencing of the Homoeologous Group-3
Chromosomes of Wheat”
Gray, Lawrence A., Pediatrics
“Mother’s Soothing: Metabolic and
Physiologic Advantages”
Grdina, David, Rad Onc
“Delayed Radioprotection by Thiols”
Glick, Benjamin, MGCB
“The Transitional ER-Golgi System
in Budding Yeasts”
“Prevention of Low Dose Radiation-Induced
Genomic Instability With Clinically Relevant
Non-Protein Thiols and Vitamin E”
Glick, Susan, Medicine
“Cultural Competence Training for Resident
Physicians”
“D609 A Novel Cytoprotectant
and Selective Antitumor Agent”
Glotzer, Michael A., MGCB
“Molecular Dissection of Cytokinesis”
Green, William, Neurobiology
National Inst. of Neurological
Disorders and Stroke
“The Neuronal a-bungarotoxin Binding Site”
Glotzer, Michael A., MGCB
“Control of Central Spindle Assembly”
Goldberg, Jay M., NPP
“Cellular Mechanisms of the Vestibular System”
Goldstein, Steve A.N., Pediatrics
“Research Career Training in Pediatrics”
“Cardiac K2P and Kv4 Potassium Channels”
“Investigation of the Role of Staphylococcus
aureus Cytotoxins and Heme-Iron Uptake
Pathways in a Murine Model of Pneumonia”
Greenberg, Jean, MGCB
“Mechanism of ACD2 in Plant Cell
Survival During Abiotic Stress”
“Molecular Basis of Pathogen-Induced
Cell Death in Plants”
“Comparative Analyses of Resistance
Gene Evolution”
“ALD1-Dependent Signaling in the Plant
Defense Response”
“Effectors Required for Epiphytic Growth
of P Syringae”
Golovkina, Tatyana, Microbiology
“Subversion of Innate Immune Response
by Retroviruses”
Greene, Geoffrey, Ben May Dept Can Res
“Graduate Training Program in Cancer Biology”
Golovkina, Tatyana, Microbiology
“Novel Pathways in Retroviral Tumorigenesis”
Grove, Elizabeth, Neurobiology
“The Role of the Cortical Hem
in Patterning the Telencephalon”
“Molecular Mechanisms of Cerebral
Cortical Patterning”
“The Specific Role of FGF8 and FGF17
in Cortical Patterning”
Gupta, Mahesh P., Surgery
“The Role of PARP-SIR2 Signalling
in Heart Failure”
Hale, Melina E, Organ Bio and Anatomy
“Reticulospinal Control of Alternative
Startle Behaviors”
Halpern, Howard, Rad Onc
and Bioengineering
“Very Low Frequency EPR Imaging for
in Vivo Physiology”
Halpern, Howard, Rad Onc
and Bioengineering
“Magnitude Improvement of Molecular
Signaling Imaging”
Hamann, Kimm Jon, Medicine
“Oxidants and Caspases: Initiation of
Reperfusion Injury”
Hanck, Dorothy, Medicine
“Cardiac Channels: Targets of Drugs That
Affect Kinetics”
Haraf, Daniel J., Rad Onc
“Oropharyngeal Function After Radiotherapy
With Intensity Modulated Radiation
Therapy (IMRT)”
Harvey, Ronald G., Ben May Dept Can Res
“Molecular Mechanisms of Multistage
Carcinogenesis: Core 2”
Harvey, Ronald G., Ben May Dept Can Res
“Molecular Mechanisms of Multistage
Carcinogenesis: Project 2”
Hatsopoulos, Nicholas G., Organ Bio and
Anatomy
and Stroke
“Coding of Action by Motor and Premotor
Cortical Ensembles”
Haydon, Rex C., Surgery
“BMP6-Mediated Osteogenesis”
He, Tong-Chuan, Surgery
“Regulation of Beta-Catenin Signaling by
Tyrosine Phosphorylation”
2007 ANNUAL REPORT
41
Herbst, Arthur L., Ob Gyn
“Continuation of Follow-Up of
DES Exposed Cohorts”
Ho, Robert K. Organ Bio and Anatomy
and Kidney Diseases
“Specification of Blood Lineages in
a Vertebrate Embryo”
Hoover, Robert, Medicine
and Kidney Diseases
“Regulation of the Sodium Chloride
Cotransporter”
Kang, Un Jung, Neurology
and Stroke
“The Neuroprotective Mechanism of DJ-1
in Parkinson’s Disease”
Karczmar, Gregory, Radiology
and Bioengineering
“High Spectral and Spatial Resolution
Imaging of Breast Cancer”
“Fast Spectroscopic MR Imaging of
Breast Cancer”
Huang, Elbert, Medicine
“Individualizing Diabetes Care
for Older People”
“Dynamic Spatial and Spectral Contrast
Enhanced MRI of Breast”
Imamoto, Akira, Ben May Dept Can Res
National Institute for Dental Research
“Developmental/Genetic Analysis
of DiGeorge Models”
Kee, Barbara Lynne, Pathology
“Regulation of Lymphocyte Development
by Helix-Loop-Helix Proteins”
Jablonski, David, E&E
“Macroevolutionary Consequences of
Abundance in Paleogene Bivalves”
Keenan, Kathryn, Psychiatry
“Preadolescent Precursors to
Depression in Girls”
Jabri, Bana, Pathology
and Kidney Diseases
“IEL and NKG2 Receptors in Celiac Disease”
Kent, Stephen Brian Henry, BMB
“A Systemic Approach to the Chemical
Synthesis of G-Protein Coupled Receptors
and Kidney Diseases
“Regulation of Normal Human
IEL By NKGD2D and IL-15”
Kidwell, Susan M., Evol Biology
“Ecological Insight from Temperate
Large-Mammal Death Assemblages
in Yellowstone National Park”
“Mechanism Underlying Immune-Modulatory
Effects of LcrV”
Jacobson, Jeffrey, Medicine
“Endothelial Barrier Regulation by Simvastatin”
Jacobson, Kristen, Psychiatry
“The VETSA Longitudinal Study of Cortisol
and Aging”
Josephs, Robert, MGCB
“Structure, Interaction, and Mechanism
in Sickle Hemoglobin”
Kalinichenko, Vladimir, Medicine
“Fox Transcription Factors in Development
of Pulmonary Capillaries”
Kang, Un Jung, Neurology
and Stroke
“The Neuroprotective Effect of
Tetrahydrobiopterin”
Kindler, Hedy, Medicine
“Phase II Study of BAY 43-9006 for Patients
with Imatinib-Resistant Gastrointestinal
Stromal Tumors”
King, Andrea C., Psychiatry
“Efficacy of Naltrexone in Women’s
Smoking Cessation”
King, Andrea C. Psychiatry
National Institute on Alcohol Abuse
and Alcoholism
“Alcohol Stimulation and Sedation
in Binge Drinkers”
King, Andrea C., Psychiatry
National Institute on Alcohol Abuse
and Alcoholism
“Alcohol Effects on Smoking Urge
and Behavior”
Kittles, Rick, Medicine
Department of Defense
“Admixture Mapping for Prostate Cancer
Susceptibility Genes in African Americans
“EphB2 as a Prostate Cancer Tumor Suppressor
and Risk Factor in African Americans”
Department of Health and Human Services
“Construction and Application of a US
Admixture Map”
Lahey, Benjamin, Health Studies
“Genetic Epidemiology of Youth
Conduct Problems”
Li, Qiang, Radiology
“CAD for Lung Cancer Detection and
Classifiction in CT”
Maki, Carl G., Rad Onc
“P53 Localization and Activity
in Normal and Human Tumor Cells”
Konetzka, Rita Tamara, Health Studies
“The Impact of Public Reporting on Nursing
Home Quality of Care”
Lahn, Bruce T., Human Genetics
“Paralleling Single-Cell Gene
Expression Profiling”
Li, Wen-Hsiung, E&E
“Statistical Studies of DNA Evolution”
Maki, Carl G., Rad Onc
“Physical and Functional Interactions Between
PML and MDM2”
Kossiakoff, Anthony, BMB
“Integrated Centers for Structure and
Function Innovation”
Lal, Ratneshwar, Medicine
“Amyloid Ion Channels to Design Therapeutics
for Neurodegenerative Diseases”
Kossiakoff, Anthony, BMB
“Chaperone Assisted Crystallography”
Lam, Ying-Wan, Neurobiology
and Stroke
“Circuit Basis of the Cortical Control of
Sensory Information Flow in the Thalamus”
Kraig, Richard, Neurology
and Stroke
“Glial Reaction to Ischemic Brain Injury”
Kreitman, Martin, E&E
“Resolving Spatial Patterning and Egg Size
in Drosophila”
Kron, Stephen J., MGCB
“Molecular Library Screening By MALDI-TOF
Scanning Of Functional Peptide Arrays”
“BCR-ABL Kinase Assays for STI571
Sensitivity or Response”
Kidney Diseases
“Undergraduate Training Program in
Chemical and Physical Biology”
“Radiation-Induced G1 Checkpoint Arres
in Yeast”
“Bcr-Abl Thiophosphorolation Profiling
in Chronic Myelogenous Leukemia (CML)
Using Matrix Assisted Laser Desorption
Ionisation (MALDI)”
“Role of the Lig3 BRCT Domains
in DNA Repair”
and Kidney Diseases
“Undergraduate Training Program in
Chemical and Physical Biology”
Lahey, Benjamin, Health Studies
“Validity of DSM-IV Subtypes of Attention
Deficit Hyperactivity Disorder (ADHD)
for Young Children”
Lamppa, Gayle K., MGCB
“A Novel Genetic Strategy to Explore the
Chloroplast Import Pathway”
Lauderdale, Diane S., Health Studies
“Time Allocated for Sleep:
Sociodemographic Correlates
and Secular Change”
Le Grange, P. Daniel F., Psychiatry
“Treatment for Adolescent Anorexia Nervosa”
Le Grange, P. Daniel F., Psychiatry
“Ecological Momentary Assessment
of Anorexia Nervosa”
Le Beau, Michelle M., Medicine
“Etiology of Treatment Induced
Secondary Leukemia”
Lee, Kwang-Sun, Pediatrics
“Competition, Volume, NICU Level and
Outcome in California”
Lee, Raphael, Surgery
“Non-Ionizing Research: Electrical Stimulation
of Biological Tissues”
Leff, Alan, Medicine
“Transcellular Communication in
Airway Inflammation and Airway
Hyperresponsiveness”
Li, Yanchun, Medicine
“Cardiovascular Effect of the Vitamin D
Endocrine System”
and Kidney Diseases
“Vitamin D and Diabetic Nephropathy”
“Preventative Role of Vitamin D Receptor (VDR)
in Colorectal Carcinogenesis”
Lin, Anning, Ben May Dept Can Res
“Integration of TNF Signaling in Apoptosis”
Lin, Anning, Ben May Dept Can Res
“Targeting BAD by c-Jun N-terminal kinase
(JNK) for Cell Survival”
Lingen, Mark W., Pathology
“Molecular Profiling of Premalignant
Oral Lesions”
Lingen, Mark W., Pathology
“Oral Cancer, Chemoprevention,
and Anti-Angiogenesis”
Makinen, Marvin W., BMB
“Predoctoral Training Program in Chemistry
and Biology”
Malamy, Jocelyn, MGCB
“The Adaptation of Plant Development to
Environmental Stress”
Margoliash, Daniel, Organ Bio and Anatomy
“Characterization of Non-Linear Auditory
Receptive Fields”
“Neurophysiology of Sensorimotor Learning”
“CRCNS: Statistics of Temporal Patterns in
Sleep Mechanisms of Learning”
National Institute on Deafness
and Other Communication Disorders
“Cholinergic Regulation of a Sensorimotor
Nucleus”
Lipton, Rebecca Bornstein, Pediatrics
and Kidney Diseases
“Chicago Childhood Diabetes Registry”
Marks, Jeremy, Pediatrics
and Stroke
“Mechanisms of Copolymer-Mediated
Neuroprotection”
Llano, Daniel, Neurology
National Institute on Deafness
and Other Communication Disorders
“Functional Organization of Auditory
Corticothalamic Projection Systems”
Marks, Jeremy, Pediatrics
“Imaging Polymer-Mediated Repair of the
Neuronal Plasma Membrane at the Nanoscale
Level”
Long, Manyuan, E&E
“Detection of Distribution of New Genes
in Drosphila Phylogeny”
Mason, Peggy, Neurobiology
“Training in Neural Systems”
Long, Manyuan, E&E
“Variation of D. melanogaster Chromosome 4”
Lengyel, Ernst Robert, Ob Gyn
“Regulation of Adhesion and Proteolysis
in Ovarian Cancer”
Long, Manyuan, E&E
“Genomic Analysis for Rates and Patterns of
New Gene Originations in Drosophila”
Lesniak, Maciej S., Surgery
and Stroke
“Targeted Adenoviral Gene Therapy for
Malignant Glioma”
Macleod, Kay, Ben May Dept Can Res
“Functions of pRb in Stress Erythropoiesis”
Madara, James L., Pathology
and Kidney Diseases
“Functional Morphology of Intestinal
Permeability”
and Stroke
“Pain Modulation and Visceral Stimulation”
and Stroke
“Roles for VMM Cells During Micturation and
Continence”
Mastrianni, James A., Neurology
and Stroke
“The Role of the Lyosome in
ER-Associated Degradation of Prp”
2007 ANNUAL REPORT
43
Matlin, Karl S., Surgery
“Cell-Matrix Interactions in Epithelial
Polarization”
Meltzer, David, Medicine
Centers for Disease Control
“Chicago Center of Excellence in Health
Promotion Economics”
Olopade, Olufunmilayo, Medicine
“Basic Medical Research Training in
Medical Oncology”
Phan, Kinh Luan D., Psychiatry
“Neuro-Genetic Markers of SSRI Treatment
Response in Social Anxiety Disorder”
“Effectiveness of Training Early Achievers for
Careers in Health (TEACH) Research”
Nicosia, Antonia, Ob Gyn
Agency for International Development
“A Multicenter, Open-Label Study on the
Efficacy, Cycle Control and Safety of a
Contraceptive Vaginal Ring Delivering a Daily
Dose of 150mcg of Nestrorone and 15mcg of
Ethinylestradiol (150/15 NES/EE CVR)
Protocol 300 B”
Matthews, Jeffrey B., Surgery
and Kidney Diseases
“Salt Transport in Surgical Diarrheal Disease”
Palmer, Abraham A., Human Genetics
“Mouse QTL Translational Genetic Study
of Methamphetamine Sensitivity”
Philipson, Louis, Medicine
and Kidney Diseases
“Minority Predoctoral Fellowship Program”
Mc Gehee, Daniel S., Anesthesia & CC
“Nicotinic Modulation of the
Mesoaccumbens DA System”
“MD/PhD Program in Medicine, Social
Sciences, and Aging”
Nishikawa, Robert, Radiology
“High-Performance Computer Cluster
for Image Analysis”
Palmer, Abraham A., Human Genetics
“Translational Genetic Study of Fear
and Anxiety”
“The Processing of Tonic and Burst Activity
Patterns in DA Terminals in the NAcc”
Meredith, Stephen C., Pathology
National Inst. of Neurological
Disorders and Stroke
“N-Methyl and Other Peptide Inhibitors
of Fibrillogenesis”
Noth, Imre, Medicine
“Combination Therapy in Idiopathic
Pulmonary Fibrosis”
Pan, Tao, BMB
“Kinetic/Thermodynamic/Structural Studies of
RNA Folding”
Pilipenko, Evgeny, Microbiology
Diseases
“The Role of Proteasomes in Viral
RNA Translation”
Noth, Imre, Medicine
“IPFnet: Idiopathic Pulmonary Fibrosis
Clinical Research Network”
Pan, Xiaochuan, Radiology
and Bioengineering
“Targeted Imaging in Helical Cone Beam CT”
Ober, Carole, Human Genetics
“Sex-Specific Genetic Architecture of
Asthma-Associated Quantitative Traits”
Pan, Xiaochuan, Radiology
“Phase-enhancement Micro-Computed
Tomography”
“Positional Cloning of a 6p-Linked
Asthma Gene”
Peek, Monica, Medicine
and Kidney Diseases
“The Impact of Shared Decision-Making
Among African-Americans with Diabetes”
“Nicotinic and Dopamine Receptor
Interactions in the Ventral Tegmental
Area (VTA)”
“Adolescent Cocaine Abuse:
Electrophysiology and Behavior”
McCloskey, Michael S., Psychiatry
“Individual Cognitive-Behavioral Psychotherapy
for Intermittent Explosive Disorder (IED)”
McCrea, Robert A., Neurobiology
“Physiology of Oculomotor Premotor Pathways”
McDade, William A., Anesthesia & CC
and Kidney Diseases
“The University of Chicago Young
Scientist Program”
Millen, Kathleen J., Human Genetics
and Stroke
“Genetic Analysis of Roof Plate Function
in the Central Nervous System (CNS)”
Millen, Kathleen J., Human Genetics
“Finding the Cause of Vertebrate
Congenital Caudal Duplication”
Miller, Michael, Evol Biology
“Patterns and Processes of Diversity
in Arbuscular Mycorrhizal Fungi
(Glomeromycota)”
Moffat, John Keith, BMB
“Time-Resolved Macromolecular
Crystallography”
“Gene-Environment Interactions and
the Origins of Asthma”
“HLA-G at the Maternal-Fetal Interface”
Popko, Brian J., Neurology
and Stroke
“Genetic Analysis of Glycan Function in
Myelinating Cells”
Qin, Kenan, Pediatrics
National Institute of Child Health and
Human Development
“Regulation of Testosterone Synthesis in
Theca Cells”
Quigg, Richard, Medicine
and Kidney Diseases
“Pathogenic Role of the Complement
System in Murine Lupus”
and Kidney Diseases
“Nephrology Research Training”
“Targeting Complement Inhibitors to the Human
Proximal Tubule”
Popko, Brian J., Neurology
and Stroke
“National Center for Drug Discovery in
Neurodegeneration”
Quinn, Michael T., Medicine
“Increasing Organ and Tissue Donation in the
Service Industry/Factory Workplace: A Peer
Educator Approach”
Posner, Mitchell C., Surgery
“American College of Surgeons Oncology
Group—Chair, Gastrointestinal Committee”
Quintans, Jose, Pathology
“Medical Scientist National Research
Service Award”
Preuss, Daphne, MGCB
“Cell-Cell Interactions During Pollen
Tube Guidance”
Ramirez, Jan-Marino, Organ Bio and Anatomy
“Substance P in the Central Respiratory
Neural Network”
Preuss, Daphne, MGCB
“Dynamics of Centromere Evolution in the
Brassicaceae Family”
Ramirez, Jan-Marino, Organ Bio and Anatomy
“Hypoxic Effects on Mammalian Respiratory
Neural Network”
Price, Trevor D., E&E
“Analysis of Regional Variation in Bird Species
Diversity Along the Himalayas”
Ratain, Mark J., Medicine
“Pharmacogenetics of Anticancer Agents
Research Group”
Peter, Marcus E., Ben May Dept Can Res
“The Role of CD95 as a Tumor Promoter”
Prince, Victoria E., Organ Bio and Anatomy
Human Development
“Role of cdx Genes and RA in
Regionalizing the Endoderm”
“Phase I Clinical Trials of Anticancer Agents”
Pelizzari, Charles, Rad Onc
Army Research Office
“Cone-Beam Computed Tomography for ImageGuided Radiation Therapy of Prostate Cancer”
Perozo, Eduardo, Pediatrics
“High Resolution Structural Dynamics
of K Channels”
Mueller, Gregory M., Evol Biology
Department of Education
“Graduate Assistance in Areas of National
Need: Evolutionary Environmental Biology”
“Molecular Genetic Studies of Fertility
in the Hutterites”
Natarajan, Viswanathan, Medicine
“Nox4 in Endothelial Cell ROS Production,
Signaling, and Motility”
“Genetic and Mechanistic Determinants
of Rhinovirus-Induced Asthma”
McNally, Elizabeth M., Medicine
“Cardiovascular Sciences Training Grant”
Natarajan, Viswanathan, Medicine
“Intracellular S1P and Signaling in Lung
Endothelial Cells”
Odenike, Olatoyosi, Medicine
“Phase I Study of PXD101 in Combination with
5-Aza for Advanced Hematologic Malignacies”
“Molecular Characterization of the
Two CD95 Pathways”
Prince, Victoria E., Organ Bio and Anatomy
Kidney Diseases
“Early Development of the Zebrafish Pancreas”
“Sulfonylurea KATP Channels
in Vascular Spasm”
Naureckas, Edward, Medicine
Veterans' Administration
“Outcomes Associated With Salmetrol Use
in Obstructive Lung Disease”
“CD95 Signaling Mechanisms”
Pritchard, Jonathan K., Human Genetics
“Linkage Disequilibrium Methods for Complex
Trait Mapping”
“Sarcoglycan in Myopathy and Muscle
Membrane Stability”
Petrof, Elaine, Medicine
and Kidney Diseases
“Probiotic Effects on Gut Epithelial HSPs
and NF-kB”
Rathouz, Paul, Health Studies
“Social-Emotional Contexts of Adolescent
Smoking Patterns”
Nelson, Deborah, NPP
“Role of Ion Channels in Mononuclear
Phagocyte Activation”
Ojakangas, Catherine, Surgery
and Stroke
“Cerebral Mechanisms of Skill Learning
in Humans”
Pruett-Jones, Stephen, E&E
“Mechanisms of Sperm Competition
in Fairy Wrens”
Rebay, Ilaria, Ben May Dept Can Res
“Cell-Cell Signaling in Embryonic and Retinal
Development”
“Molecular Regulation of Cardiac KATP
Channels in Ischemia”
Newstead, Gillian, Radiology
“New Approaches to Sampling and
Analyzing Contrast Media”
Pfister, Catherine, E&E
Department of Education
“Graduate Assistance in Areas
of National Need: Ecology”
Przeworski, Molly, Human Genetics
“Identifying Human Adaptations: Theory and
Applications”
Reder, Anthony T., Neurology
“Treatment of Multiple Sclerosis”
McKee, Mark D., Surgery
“CEA-Directed Cancer Treatment
with Gene-Modified T Cells”
McLeod, Rima, Ophthalmology
“Innate Immune Receptors for
Toxoplasma Gondii”
“Chicago Specialized Programs of Research
Excellence (SPORE) in Breast Cancer”
“Genetics of Breast Cancer in Blacks”
Perozo, Eduardo, Pediatrics
“Structural Dynamics of Mechanosensitive
Channels”
“Clinical Therapeutics”
“Clinical Trials Working Group”
2007 ANNUAL REPORT
45
Reder, Anthony T., Neurology
and Stroke
“Quality of Life Outcomes in
Neurological Disorders”
Roos, Raymond P., Neurology
and Stroke
“Picornavirus - Host Cell Interactions
and Disease”
Refetoff, Samuel, Medicine
and Kidney Diseases
“Thyroid Physiology Studies of Inherited
Disorders”
Rosenfield, Robert L., Pediatrics
and Kidney Diseases
“Pediatric Endocrinology Research Training
Grant”
Refetoff, Samuel, Medicine
and Kidney Diseases
“Integrated Clinical and Basic Science
Endocrinology Research”
Rosengart, Axel, Neurology
“Magnetically Targeted Thermal Cancer Therapy
Using Designer Nanospheres”
Schilsky, Richard, Medicine
“Quality of Life of African American
Survivors of Cancer”
Rosner, Marsha, Ben May Dept Can Res
and Stroke
“Signaling Pathways In Differentiating
Neuronal Cells”
Schneewind, Olaf, Microbiology
Infectious Diseases
“Bioterrorism: Molecular Analysis and
Intervention”
“Role of Raf Kinase Inhibitory Protein
in Prostate Cancer”
Infectious Diseases
“LcrV Plague Vaccine with Altered Immune
Modulatory Properties”
Rezania, Kourosh, Neurology
“Clinical Trial of Ceftriaxone
in Subjects with ALS”
Rhodes, Christopher J., Medicine
and Kidney Diseases
“Metabolic Control of Proinsulin
Biosynthesis Translation”
Rhodes, Christopher J., Medicine
and Kidney Diseases
“Mitogenic Signal Transduction
in Pancreatic Beta Cells”
Rice, Phoebe A., BMB
“Structure Biochemistry of RecombinaseDNA Complexes”
Rock, Ronald S., BMB
“Allostery in Myosins Studied at
the Molecular Level”
Roe, Michael W., Medicine
and Kidney Diseases
“Calcium Signaling in Pancreatic
Beta Cell Endoplasmic Reticulum”
Roizman, Bernard, Microbiology
“Functions of Herpes Simplex Virus ICP22
and US1.5”
Roizman, Bernard, Microbiology
“Dissection of the Functions of Herpes Simplex
Virus ICPO”
Roizman, Bernard, MGCB
“Selective Degradation of mRNA
by Herpes Simplex Virus 1”
Roman, Brian B., Radiology
“NMR Detection of Gene Expression”
Roman, Brian B., Radiology
and Bioengineering
“Imaging Pancreatic B-Cell Function
by Magnetic Resonance”
“Modulation of Head and Neck Cancer by
Protein Kinase C”
Ross, Helaine Friedman, Pediatrics
“Ethical Issues in Living Donor Transplantation”
Roth, Steven, Anesthesia & CC
“The Role of Adenosine in Retinal Ischemia”
Rothman-Denes, Lucia, MGCB
“Genetics and Regulation (NRSA)”
Rothman-Denes, Lucia, MGCB
Infectious Diseases
“Novel Transcribing Activities in N-4
Infected E. coli”
Sanchez-Johnsen, Lisa A.P., Psychiatry
“Cultural Proficient Smoking and Weight
Control Treatment”
Scanu, Angelo M., Medicine
“Biology of Proteolytic Derivatives of Lp(a)”
Schilsky, Richard, Medicine
“CALGB Human Specimen Repositories”
Infectious Diseases
“Surface Proteins and Sortases of Bacillus
anthracis”
Infectious Diseases
“Surface Protein Anchoring in Gram Positive
Bacteria”
Infectious Diseases
“Targeting Yop Proteins by Yersinia
Enterocolitica”
Roux, Benoit, Pediatrics
“Computational Studies of Ion Channels”
Infectious Diseases
“Biodefense Training in
Host-Pathogen Interactions”
“Polarizable Force Field for Proteins
and Lipids”
Schreiber, Hans, Pathology
“CD8+ T Cells and Immunological
Tumor Regression”
“Putting Molecular Dynamics to the Test:
Ion Permeation”
“Manipulation of Tumor Specific Immunity”
Salgia, Ravi, Medicine
“Studies of a Novel Therapeutic Target in
Non-Small Cell Lung Cancer (NSCLC)”
Salgia, Ravi, Medicine
“Role of c-Met in Small Cell Lung Cancer
(SCLC) and Potential for Novel Therapies”
“Immunology of Unique Tumor
Specific Antigens”
Schwartz, Nancy B., Pediatrics
“Biological Basis of Mental Retardation”
“JP Kennedy Mental Retardation and
Developmental Disabilities Research Center
(MRDDRC)”
“Graduate Training in Growth and
Development”
“Proteoglycan Synthesis in Mutant
Mouse Systems”
“Post Baccalaureate Research Education
Program (PREP)”
Sherman, S. Murray, Neurobiology
“Effects of Visual Deprivation on the
Visual System”
“Information Processing in Sensory Systems”
“Auditory Coticothalamic Projection Sytems”
and Stroke
“The Thalamocortical Synapse in Layers IV
and VI”
Shilling, Rebecca, Medicine
Diseases
“ICOS Expression Levels and Th Development”
Shubin, Neil H., Organ Bio and Anatomy
“Late Davonian Tetapodomorph Fishes
and the Origin of Tetrapods”
Sidky, Emil, Radiology
and Bioengineering
“Helical CT Reconstruction and
Lung Cancer Screening”
Sipkins, Dorothy A., Medicine
“Imaging Cell Homing and Engraftment
in the Bone Marrow”
Sisodia, Sangram S., Neurobiology
“Modulation of Beta Amyloid Peptide
Deposition by Environmental Enrichment”
Sisodia, Sangram S., Neurobiology
“PKC Modulations for the Treatment of
Alzheimers Disease”
Small, Stephen, Anesthesia & CC
“Immersive Simulation Team Training Impact
on Rescue, Recovery, and Safety Culture”
Stadler, Walter M., Medicine
“Phase II Study of AZD2171 in Pts with
Advanced Refractory Renal Cell Carcinoma”
Small, Steven L., Neurology
National Institute on Deafness and
Other Communication Disorders
“Functional Neuroanatomy of Normal
and Impaired Language”
Staley, Jonathan P., MGCB
“Mechanisms for Rearranging RNA During
Pre-mRNA Splicing”
“Neurophysiological Measurement in
Aphasia Treatment”
“Bioinformatics Infrastructure for
Large Scale Studies of Aphasia Recovery”
Smith, Peter J., Pediatrics
Maternal and Child Health Bureau
“Illinois Medical Home Project”
Solway, Julian, Medicine
National Institute of Allergy
and Infectious Diseases
“Molecular Mechanisms of Asthma”
“Research Training in Respiratory Biology”
“Plasticity Regulation of Contracted Airway
Smooth Muscle”
“Imaging Airway Myocyte Ca2+ Signaling
in Living Animals”
Sosnick, Tobin R., BMB
“Kinetic Studies of Protein Folding”
Sosnick, Tobin R. BMB
“The Protein Problem”
Spergel, Daniel J., Medicine
National Institute of Child Health and Human
Development
“Calcium Signaling in the Pubertal Activiation
of the GnRH Pulse Generator”
Sperling, Anne I., Medicine
Infectious Diseases
“CD43 Regulation of Immune Responses”
Sperling, Anne I., Medicine
“Mechanisms of Resolution in
Experimental Asthma”
Stadler, Walter M., Medicine
“Dynamic Contrast-Enhanced MRI
as a BAY 43-9006 Marker”
Steinberg, Gary, Surgery
“Bladder Ca Microsatellite Analysis of
Urinary Sediment”
Stephens, Matthew, Ben May Dept Can Res
“Genome Analysis: Data Accuracy,
Haplotyping and Mapping”
Stephens, Matthew, Human Genetics
“Multipoint and Significance Methods for
Genome-Wide Association Studies”
Storb, Ursula B., MGCB
Infectious Diseases
“Mechanism of Immunoglobulin
Hypermutation”
Storb, Ursula B., MGCB
Infectious Diseases
“Immunoglobin Somatic Mutation”
Sun, Xiao Jian, Medicine
and Kidney Diseases
“Mechanism of Insulin-Induced
Ubiquitination of IRS-1”
Svensson, Eric C. Medicine
“Transcriptional Regulation of
Cardiac Development”
Sweiss, Nadera, Medicine
Diseases
“SCSSc-01: High-Dose Immunosuppressive
Therapy Using Total Body Irrasiation,
Cyclophosphamide, TGAM, and Autologous
Transplantation with Auto-CD34+HPC vs
Intravenous Pulse Cyclophosphamide for the
Tx of Severe Systemic Sclerosis (SCOT)”
Tang, Wei-Jen, Ben May Dept Can Res
“Calmodulin-Activated Adenyl Cyclase Toxins”
Tang, Wei-Jen, Ben May Dept Can Res
“SK2-Associated Protein Kinase CK2:
Molecular Basis and Physiological Roles”
Tasali, Esra Fatma, Medicine
“Pathways Linking Reduced Sleep Duration and
Quality to Obesity Risk”
Thinakaran, Gopal, Neurobiology
“Amyloidogenic Processing of APP”
2007 ANNUAL REPORT
47
Thinakaran, Gopal, Neurobiology National Inst.
of Neurological Disorders and Stroke
“Mouse Model for Neuroprotection”
Thirman, Michael J., Medicine
“MLL Fusions and Cooperating Mutations
in Acute Leukemia”
Thirman, Michael J., Medicine
“Molecular Genetics of MLL-Associated
Leukemia”
Thistlethwaite, J. Richard, Surgery
Infectious Diseases
“Immunosuppression Withdrawal in Liver
Transplant Recipients Workscope: Planning
Grant for Clinical Trial of Immunosuppression
Withdrawal in Liver Transplant Recipients”
Tupesis, Janis, Medicine
“Bioterrorism Training and Curriculum
Development Program (BTCDP)”
Turkewitz, Aaron, MGCB
“Biogenesis of Dense Core Secretory Granules
in Tetrahymena”
Turkewitz, Aaron, MGCB
“Characterization of a Dynamin-Related
Protein Involved in Endocytosis in
Tetrahymea thermophila”
Turner, Jerrold R., Pathology
and Kidney Diseases
“Regulation of Paracellular Permeability by
IFNgamma and TNFalpha”
and Kidney Diseases
“Physiological Regulation of Intestinal
Epithelial Transport and Barrier Function”
“Regulation of Intestinal Transport”
Ulinski, Philip S., Organ Bio and Anatomy
“Training in Computational Neuroscience”
“Undergraduate Training in Computational
Neuroscience: From Biology to Model and
Back Again”
“Computational Neuroscience Annual Meeting”
Van Besien, Koen, Medicine
“Busulfan Conditioning: Optimization,
Kinetics, Genomics”
Van Cauter, Eve, Medicine
“Alterations of Circadian Timing in
Sleep and Aging”
and Kidney Diseases
“Sleep Disturbance as a Non-Traditional Risk
Factor in Chronic Kidney Disease (CKD)”
“Predictors of Adverse Metabolic Effects of
Sleep Loss”
Van Voorhees, Benjamin, Medicine
“Primary Care-Based Depression Prevention
for Adolescents”
Van Voorhees, Benjamin, Medicine
“Development of Internet Intervention
for Depression”
Vanden Hoek, Terry L., Medicine
“Optimizing Heart and Brain Cooling During
Cardiac Arrest”
Vanden Hoek, Terry L., Medicine
Office of Naval Research
“Proteomic Development of Molecular Vital
Signs: Mapping a Mitochondrial Injury
Severity Score to Triage and Guide
Resuscitation of Hemorrhagic Shock”
Verin, Alexander, Medicine
“Microtubules in Lung Endothelial
Cell Barrier Regulation”
Verin, Alexander, Medicine
“ATP in Lung Endothelial Barrier
Enhancement”
Vezina, Paul, Psychiatry
“Nicotine Exposure: Molecular to
Behavioral Consequences”
“Neuropsychopharmacology Training in Drug
Abuse Research”
“Sensitization and Stimulant
Self-Administration”
Vokes, Everett E., Medicine
“Clinical Trials Working Group”
Vokes, Tamara, Medicine
“Clinical Utility of Texture Analysis in
Osteoporosis”
Wang, Chyung-Ru, Pathology
Infectious Diseases
“Regulation and Function of Murine CD1
Molecules”
Wang, Chyung-Ru, Pathology
Infectious Diseases
“Group 1 CD1 in Infectious Disease and
T-Cell Development”
Wang, Eileen Y., Ob Gyn
Human Development
“Placental Progesterone Biosynthesis
in Preterm Pregnancy”
Wang, Zhenguo, Medicine
“Creating Oncolytic Adenovirus Targeting
Tumor Lympahtics”
Webb, Gene C., Medicine
and Kidney Diseases
“Signal Transduction Leading to Insulin
Synthesis”
Weichselbaum, Ralph R., Rad Onc
“Mechanisms of Resistance to Radio Inducible
Gene Therapy”
Weichselbaum, Ralph R., Rad Onc
“DNA Damage Targeted Gene Therapy in
Head and Neck Cancer”
Weigert, Martin, Pathology
“Genetics and Regulation of Autoantibodies”
Weiss, Roy, Emanuel, Medicine
“Nuclear Cofactors in Human Thyroid Disease”
White, Kevin P., Human Genetics
“A Cis Regulatory Map of the Drosophila
Genome”
“Comparative Studies of Gene Regulation in
Drosophila”
“Genomic Analyses of Drosophila Development”
“The Mechanisms and Regulatory Networks
of Alternative Splicing in Drosophila”
“Molecular Genetics of Caloric Restriction
in Aging Flies”
White, Steven, Medicine
“Regulation of Airway Epithelial Repair”
Wickrema, Amittha, Medicine
“Transcriptional Regulation of Myeloma
Cell Growth”
Zhuang, Xiaoxi, Neurobiology
“Genetic and Behavioral Dissection
of Inhibitory Control”
Wicksteed, Barton, Medicine
and Kidney Diseases
“Does Insulin or Glucose Regulate
Alpha-Cell Function?”
“Epigenetic Mechanisms in
Motor Habits Stability”
Wolfe, Andrew, Pediatrics
Human Development
“Growth Factor Regulation of the
GnRH Neuron”
“Genetic Manipulation of Phasic
Dopaminergic Activity”
Wootton, John Timothy, E&E
“River Food Web Response to Riparian
Zone Management”
Wootton, John Timothy, E&E
“Quantitative Interaction Strengths in
Omnivorous Food Webs Across a Gradient
in Primary Productivity”
Wu, Chung-I, E&E
“Transcriptional and Genic Basis of Incipient
Speciation”
Xu, Ming, Anesthesia & CC
“Molecular Determinants of Compulsive
Cocaine-Taking”
Xu, Ming, Anesthesia & CC
“Role of C-Fos In Cocaine Actions”
Yu, Ping, Pathology
Infectious Diseases
“Generation and Analysis of Immunity Inside
Tumor Tissues”
Yuan, Chun-Su, Anesthesia & CC
National Center for Complementary and
Alternative Medicine
“Herbal Effects on Oxidant Dynamics of
Cardiomyocytes”
Zacny, James P., Anesthesia & CC
“Behavioral Effects of Opioids in Volunteers”
Zacny, James P., Anesthesia & CC
“A Model of Inhalant Abuse Using Inhalant
Responders”
Zhang, Jian, Medicine
“Cbl-b in T Cell Activation and Autoimmunity”
Zhang, Jian, Medicine
“IL-4 Potentiates T Cell Death in
Autoimmune Arthritis”
2007 ANNUAL REPORT
49
2007 Annual Report
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