scientific report 2015–2016 - Tel Aviv University Center for

Transcription

The Center for
Nanoscience
& Nanotechnology
SCIENTIFIC REPORT 2015–2016
Center for
Nanoscience &
Nanotechnology
Tel Aviv University
Tel Aviv University Center for
Nanoscience & Nanotechnology
Powering Innovation
Center for
Nanoscience &
Nanotechnology
Tel Aviv University
Center for
Nanoscience
& Nanotechnology
SCIENTIFIC REPORT
May
2016
Contents
Overview.......................................................................................................................................................................................................................6
Hubs of Innovation...............................................................................................................................................................................................7
The Micro & Nano Characterization & Fabrication Facility (MNCF)....................................................................................7
XIN Center.............................................................................................................................................................................................................7
Educational Activities........................................................................................................................................................................................8
International Summer School on Nanomedicine, Tel Aviv University.............................................................................8
Autumn Innovation Forum, Beijing.......................................................................................................................................................8
Winter School on Nano-Photonics, Tel Aviv University.............................................................................................................8
The Fred Chaoul TAU 10th Annual Nano Workshop, Hagoshrim ......................................................................................9
XIN Winter School on Physics at the Edge:, Tel Aviv University............................................................................................9
XIN Autumn Innovation Forum, Tsinghua University, Beijing...............................................................................................9
IEEE–Gertner Summer School on Nanomedicine, Tel Aviv University............................................................................9
Intersecting Pathways ..................................................................................................................................................................................9
School Visits..........................................................................................................................................................................................................9
A New Building for Tel Aviv University’s Center for Nanoscience & Nanotechnology ................................10
Researchers..............................................................................................................................................................................................................11
Dr. David Sprinzak..........................................................................................................................................................................................13
Prof. Alexander Kotlyar...............................................................................................................................................................................14
Dr. Iftach Nachman.......................................................................................................................................................................................15
Prof. Abdussalam Azem.............................................................................................................................................................................16
Prof. Karen B. Avraham................................................................................................................................................................................17
Prof. Uri Ashery................................................................................................................................................................................................18
Prof. Itai Benhar...............................................................................................................................................................................................19
Dr. Noam Shomron.......................................................................................................................................................................................21
Dr. Avigdor Eldar.............................................................................................................................................................................................22
Prof. Roy Beck...................................................................................................................................................................................................23
Dr. Yael Roichman..........................................................................................................................................................................................24
Dr. Yair Shokef...................................................................................................................................................................................................25
Prof. Tamir Tuller..............................................................................................................................................................................................26
Dr. Sharly Fleischer........................................................................................................................................................................................27
Prof. Eli Eisenberg...........................................................................................................................................................................................28
Dr. Amir Goldbourt.......................................................................................................................................................................................29
Prof. David Andelman.................................................................................................................................................................................30
Prof. Natan Shaked........................................................................................................................................................................................31
Prof. Yael Hanein.............................................................................................................................................................................................32
3 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY
CENTER FOR NANOSCIENCE & NANOTECHNOLOGY
Prof. Slava Krylov............................................................................................................................................................................................33
Prof. Gil Rosenman........................................................................................................................................................................................34
Dr. Yuval Ebenstein.......................................................................................................................................................................................35
Prof. Yosi Shacham........................................................................................................................................................................................36
Prof. Shachar Richter....................................................................................................................................................................................37
Prof. Michael Gozin.......................................................................................................................................................................................38
Prof. Chanoch Carmeli................................................................................................................................................................................39
Prof. Yossi Rosenwaks..................................................................................................................................................................................40
Dr. Tal Dvir...........................................................................................................................................................................................................41
Dr. Alexander Golberg................................................................................................................................................................................42
Prof. Judith Rishpon.....................................................................................................................................................................................43
Prof. Noam Eliaz..............................................................................................................................................................................................44
Dr. Oswaldo Dieguez...................................................................................................................................................................................45
Prof. Oded Hod................................................................................................................................................................................................46
Dr. Amir Natan.................................................................................................................................................................................................47
Prof. Michael Urbakh....................................................................................................................................................................................48
Prof. Haim Diamant......................................................................................................................................................................................50
Prof. Diana Golodnitsky ...........................................................................................................................................................................51
Prof. Gil Markovich........................................................................................................................................................................................52
Prof. Ori Cheshnovsky.................................................................................................................................................................................53
Prof. Emanuel Peled......................................................................................................................................................................................54
Prof. Abraham Nitzan..................................................................................................................................................................................55
Dr. Roey J. Amir...............................................................................................................................................................................................56
Prof. Dan Peer...................................................................................................................................................................................................57
Prof. Ronit Satchi-Fainaro..........................................................................................................................................................................58
Prof. Inna Slutsky............................................................................................................................................................................................59
Prof. Rimona Margalit..................................................................................................................................................................................60
Prof. Ehud Gazit...............................................................................................................................................................................................61
Dr. Tal Ellenbogen..........................................................................................................................................................................................62
Prof. Jacob Scheuer......................................................................................................................................................................................63
Dr. Yossi Lereah................................................................................................................................................................................................64
Dr. Alon Bahabad...........................................................................................................................................................................................65
Prof. David J. Bergman................................................................................................................................................................................66
Prof. Ady Arie....................................................................................................................................................................................................67
Prof. Amir Boag................................................................................................................................................................................................68
Dr. Moshe Goldstein....................................................................................................................................................................................69
SCIENTIFIC REPOR T 2015–2016
Prof. Yoram Dagan.........................................................................................................................................................................................70
Prof. Alexander Gerber...............................................................................................................................................................................71
Dr. Guy Cohen..................................................................................................................................................................................................72
Prof. Alexander Palevski.............................................................................................................................................................................73
Prof. Ilan Goldfarb..........................................................................................................................................................................................74
Publications.............................................................................................................................................................................................................77
Spinoffs ......................................................................................................................................................................................................................89
Startups................................................................................................................................................................................................................89
License Agreements....................................................................................................................................................................................89
Staff ...............................................................................................................................................................................................................................91
Acknowledgments.............................................................................................................................................................................................93
Scholarships............................................................................................................................................................................................................94
Overview
Tel Aviv University’s Center for Nanoscience & Nanotechnology was established in 2000,
as the first Israeli center of its kind. Since then we have expanded and grown significantly:
today the Center is affiliated with over 90 research groups, employs its own professional
staff of researchers and scientists, and runs a state-of-the-art central facility.
Tel Aviv University’s Center for Nanoscience & Nanotechnology was a pioneer and leader
in setting up a multidisciplinary environment, where laboratories from entirely different
domains work side by side under one roof. In addition, through the synergy established
between these laboratories and the Center’s Micro- and Nanofabrication Facility, a unique,
campus-wide activity was created, generating a multitude of unique projects. Over the
years we have also strengthened our ties with industry, providing extensive services to a
growing number of companies - from small startups to large corporations.
Today, with 16 years of constant growth behind it, the Center has positioned itself as an
important asset to Tel Aviv University’s researchers and the Israeli industry.
We hope you will find the information in this publication useful for identifying new
partnerships, resources and ideas. Comprehensive and constantly updated information
about the Center is available on our website at www.nano.tau.ac.il.
Hubs of Innovation
The Micro & Nano Characterization &
Fabrication Facility (MNCF)
Tel Aviv University’s Micro & Nano Characterization &
Fabrication Laboratories are the leading facilities of their
kind in Israel, with regard to providing services to both
academia and industry. More than 50 academic groups and
over 40 companies currently use the Laboratories - which
are managed by a professional team, and offer outstanding
infrastructures (thanks to a multimillion dollar investment
by both the Israeli government and TAU). The Laboratories
provide R&D services to large Israeli corporations, as well as
small startups in their earliest stages.
Since 2007, we have established standardized training routines
for students, local scientists and external users. We continue
our effort to film training sessions on specific machines in
collaboration with TEMPUS.
XIN Center
In 2014 the elite Chinese University, Tsinghua of Beijing (THU),
teamed with Tel Aviv University to launch XIN Center, a joint
venture aiming to power innovation via ties between top
Chinese and Israeli researchers in the fields of Nanoscience
and Nanotechnology.
The TAU Center’s equipment is among the most advanced
and comprehensive in Israel, spanning all types of fabrication
methods, and enabling the development of full-process
prototypes. Capabilities and technologies at the Labs include
mask design and fabrication, optical lithography and e-beam
lithography, and advanced backend techniques such as wire
bonding and dicing. Our new laser-cutting and machining
system is the first of its kind in Israel. The Labs’ process engineers
offer researchers and corporations comprehensive prototype
development services, from small-scale predefined runs to
large R&D projects and full-process development, conducted
jointly with the customer. Services - including characterization,
device design, mask preparation, sample fabrication and
backend – are continually improved and expanded, as we add
standard operating procedures of more systems, and offer
them online. Most of the equipment managed by MNCF is
housed in two buildings, and all equipment and personnel
are managed by a single financial and administrative entity.
The XIN (meaning New in Chinese) Center focuses on
collaborative, high-impact applied research, promoting
over a dozen applied research programs of TAU and THU.
A unique mentoring system is applied, whereby leading
scientists, industrialists and business figures accompany
projects throughout all stages of research, combining
internal and external resources from both Israel and China.
Emphasis is placed on co-projects conducted jointly by
researchers from both universities. Current examples include:
diagnostics and prognosis of cancer and other diseases using
the CRISPR system (Dr. Yuval Ebenstein, Prof. Ting Zhu); and
small molecules for treating Parkinson’s disease (Prof. Danny
Segal & Prof. Yan-Mei Li). Over a dozen PhD students from
both universities have already participated in exchange visits
facilitating research in the field of nanotechnology.
Educational Activities
The Center for Nanoscience & Nanotechnology organizes a
range of social and scientific activities, including an annual
workshop, monthly seminars, monthly “Nano-Beer” events,
student exchange programs and more. Over the past two
years, major activities have included:
path to commercialization. The School was organized by
Prof. Dan Peer, Dr. Artium Khatchtouriants, Dr. Inbal HazanHallevy, Prof. Karen Avraham and Prof. Yael Hanein.
Autumn Innovation Forum, October
2014, Tsinghua University, Beijing
XIN Center, a joint initiative of Tel Aviv University and Tsinghua
University, conducted its 2014 Autumn Forum in Beijing,
China. Top academics and students from both universities,
as well as entrepreneurs, investors and major government,
business and industry leaders from China and Israel, joined
together to discuss the universities’ new initiatives in the
nano-field. Dozens of early-stage technologies originating
from both universities were evaluated, and the most promising
among them were selected for further development, to be
conducted under the XIN Center. Additionally, collaborations
between researchers and student exchanges were initiated.
International Summer School on
Nanomedicine, June 2014,
Tel Aviv University
About 100 participants, including over 40 international
students, presented and discussed their novel research in
nanomedicine.
Lectures were given on the following topics: RNAi delivery,
nano-diagnostics, nano-neuro interfaces, nanotechnologies
for regenerative medicine and tissue engineering and the
Winter School on Nano-Photonics,
February 2015, Tel Aviv University
Over a hundred students and lecturers from Tel Aviv University,
Tsinghua University and other Israeli and international
universities - including Prof. John Pendry from Imperial College
and Prof. Nader Engheta from the University of Pennsylvania took part in this special event. Novel topics in nano-photonics
were presented and discussed, including: transformation
optics, meta-materials & meta-surfaces, nano-antennas and
plasmonics, quantum dots, beam shaping and nano-imaging.
The Winter School was organized by Prof. Adi Arie and Dr.
Koby Scheuer.
The Fred Chaoul TAU 10th Annual
Nano Workshop, February 2015,
Hagoshrim
IEEE–Gertner Summer School on
Nanomedicine, June 2016,
Tel Aviv University
Over one hundred of Tel Aviv University’s nanotechnology
students and lecturers presented their recent research
activities and enjoyed a range of social gatherings during this
3-day Workshop. Prof. Miles Padgett (University of Glasgow)
gave a guest lecture on shaping light for imaging and sensing.
The Workshop was organized by Dr. Tal Dvir, Dr. Tal Schwartz
and Dr. Tal Ellenbogen.
The TAU Center for Nanoscience & Nanotechnology is the
proud winner of the first ever Summer School grant from
IEEE Nano. The special Summer School for graduate students,
also supported by a generous donation from the Gertner
Institute, offers intensive training in nanomedicine. The
School’s organizers are Prof. Yael Hanein, Prof. Dan Peer and
Dr. Tal Dvir.
XIN Winter School on Physics at the
Edge: from Topological Surfaces
to Oxide Interfaces, January 2016,
Tel Aviv University
Intersecting Pathways
About 80 lecturers and students from Israel and abroad
participated in the Winter School, which included intensive
training by internationally renowned scientists – such as
Prof. Qikun Xue (Tsinghua University), Prof. Aharon Kapitulnik
(Stanford), Prof. Gabriel Aeppli (ETH), Prof. Yulin Chen (Oxford)
and Prof. Yoram Dagan (TAU). Topological surfaces and
oxide interfaces are an emerging scientific field, with great
significance for both basic and applied research. The School
was organized by Prof. Yoram Dagan and Dr. Moshe Goldstein.
XIN Autumn Innovation Forum,
October 2015, Tsinghua University,
Beijing
Top academics and students from Tel Aviv and Tsinghua
Universities, alongside entrepreneurs, investors and major
government, business and industry leaders from both
China and Israel, joined together to discuss the universities’
new initiatives in the nano-field. Promising early-stage
technologies introduced by the researchers were selected
for further development, to be conducted under the XIN
Center. Additionally, collaborations between researchers
and student exchanges were initiated.
In 2014 Tel Aviv University’s Center for Nanoscience &
Nanotechnology and the Amit Foundation established the
Intersecting Pathways project, bringing together outstanding
Torah scholars and top academic scientists for a joint learning
experience on Science & Ethics. The project builds a unique
and surprising bond that facilitates curiosity, friendship and
scholarship. Over 20 such meetings have already taken place,
attracting more than 40 frequent attendees.
School Visits
The Nano Center regularly hosts and guides groups from
k-12 schools all over Israel, in order to enrich knowledge on
nanotechnology and promote scientific excellence among
the country’s younger generation. At TAU’s advanced nano
facilities our young guests view cutting-edge experiments
from the forefront of modern science. One especially popular
demonstration is the preparation of a sensor for ionic materials,
based on an aqueous colloidal solution of electro-stable
gold nanoparticles.
A New Building for Tel Aviv University’s
Center for Nanoscience & Nanotechnology
To fulfill the growing needs of both the Center and Tel Aviv
University’s research community, a new Nano Building is
currently being planned. The modern building will house
the Nano Characterization & Fabrication Laboratory (about
600 m2), alongside 12 core research laboratories. Altogether,
about 120 engineers and researchers from academia and
industry will use the building as their main hub.
The new building will be constructed next to TAU’s Gate 2,
forming a new entrance to the University. Accessible to the
general public, it will invite visitors from the community to
experience cutting-edge science firsthand. A special space
will be dedicated to collaboration between the Center’s
researchers and their guests from both academia and industry.
The overall cost of the building is estimated at $30 M.
RESEARCHERS
(sorted by theme of research)
RESEARCHERS
Dr. David Sprinzak
Affiliation: Life Sciences
Email: [email protected]
Web: http://www.sprinzaklab.com
Research Title
Research Description
Systems developmental biology
The development of a multicellular organism is a
truly fantastic process. How genetically identical cells
differentiate into distinct cell types in an accurate
and reproducible manner remains one of the most
important questions in biology.
The long-term goal of our lab is to elucidate the
design principles of complex developmental
programs underlying organized differentiation
patterns. In particular, we are interested in: 1. How
the properties of intercellular signaling pathways
contribute to the development of tissues and organs;
2. How cellular mechanics and cellular morphology
affect, and are affected by, regulatory processes
within cells and signaling between cells.
To address these questions we apply an
interdisciplinary approach combining synthetic
biology, quantitative imaging techniques,
micropatterning technology and mathematical
models.
Selected Publications:
1. Khait I, Orsher Y, Golan O, Binshtok U, Gordon-Bar N, Amir-Zilberstein L,
Sprinzak D. Quantitative Analysis of Delta-like 1 Membrane Dynamics
Elucidates the Role of Contact Geometry on Notch Signaling. Cell
Rep. 2015 Dec 30.
2. Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S,
Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau
M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB. The
GPSM2/LGN GoLoco motifs are essential for hearing. Mamm Genome.
2015 Dec 11.
3. Yaron T., Cordova Y., Sprinzak D. Juxtacrine Signaling Is Inherently
Noisy. Biophys. J. (2014) vol. 107, Issue 10, Pages 2417–2424.
4. D. Sprinzak, A. Lakhanpal, L. LeBon, J. Garcia-Ojalvo, M. B. Elowitz.
Mutual inactivation of Notch receptors and ligands facilitates
developmental patterning PLoS Comput. Biol. 2011 Jun;7(6).
5. D. Sprinzak, A. Lakhanpal, L. LeBon, L. A. Santat, M. E. Fontes, G. A.
Anderson, J. Garcia-Ojalvo, M. B. Elowitz. Cis interactions between
Notch and Delta generate mutually exclusive signaling states,
Nature. 2010 May 6;465(729).
RESEARCHERS
Prof. Alexander Kotlyar
Web: http://www.sashakot.com/
Research Title
DNA-based nanotechnology
The main goal of our work is to develop new
conductive molecular nanowires based on G4-DNA
and complexes of DNA with metal nanoparticles.
We have synthesized nanowires composed of single
self-folded poly(G) strands of thousands of bases.
These G4-wires comprise a large number of stacked
guanine tetrads, providing better conditions for π
overlap compared to base-pairs of the canonical
double-stranded DNA. A high content of guanines,
which have the lowest ionization potential among
DNA bases, also makes charge migration through the
DNA highly probable. Indeed, we have demonstrated
charge transport in G4-DNA molecules adsorbed
in a mica substrate. Currents ranging from tens of
picoamperes to more than 100 pA were measured
on single G4-DNA molecules over distances ranging
from tens of nanometers to more than 100 nm.
These results could open a way to the realization
of nanoscale transistors and devices.
1. Eidelshtein, G., Fardian-Melamed, N., Gutkin, V., Basmanov, D., Klinov,
D., Rotem, D., Levi-Kalisman, Y., Porath, D. and Kotlyar, A. (2016).
Synthesis and Properties of Novel Silver Containing DNA Molecules.
Advanced Materials (in press).
2. Eidelshtein, G., Kotlyar, A., Hashemi, M. and Gurevich, G. (2015).
Aligned deposition and electrical measurements on single DNA
molecules. Nanotechnology 475102 (8pp).
3. Livshits, G.I., Stern, A., Rotem, D., Borovok, N., Eidelshtein, G., Migliore,
A., Penzo, E., Wind, S.J., Di Felice, R., Skourtis, S.S., Cuevas, J.C., Gurevich.
L., Kotlyar, A.B., Porath and D. (2014). Long-range charge transport
in single G4-DNA molecules. Nature Nanotechnology 9, 1040-1046.
4. Livshits, G.I., Ghabboun, J., Borovok, N., Kotlyar, A.B. and Porath D.
(2014). Comparative Electrostatic Force Microscopy of Tetra‐and
Intra‐molecular G4‐DNA. Advanced Materials 26, 4981–4985.
5. Halamish, S., Eidelshtein, G. and Kotlyar, A. (2013) Plasmon-coupled
nanostructures comprising finite number of gold particles. Plasmonics
8, 745-748.
RESEARCHERS
Dr. Iftach Nachman
Cell fate decisions in differentiation and reprogramming
4. Smith, Z.D., Nachman, I., Regev, A., Meissner, A.
(2010). Dynamic single-cell imaging of direct
reprogramming reveals an early specifying event.
Nature Biotechnol. May;28(5):521-6.
5. Yurkovsky, E., Nachman, I. (2013). Event timing
at the single cell level. Brief Funct Genomics.
12(2):90-8.
1. Goldshmidt, Y., Yurkovsky, E., Reif, A., Rosner, R., Akiva, A., Nachman,
I. (2015). Control of relative timing and stoichiometry by a master
regulator. PLoS One 10(5), e012733.
2. Pour, M., Pilzer, I., Rosner, R., Smith, Z.D., Meissner, A., Nachman, I.
(2015). Epigenetic predisposition to reprogramming fates in somatic
cells. EMBO reports 16, 370-378.
3. Aidelberg, G., Goldshmidt, Y., Nachman, I. (2012). A microfluidic
device for studying multiple distinct strains. J Vis Exp, (69), e4257,
doi:10.3791/4257.
Our goal is to understand how cells within a
population reach developmental decisions at the
phenotypic and mechanistic level: How do cells
“decide” to change their state? Why do similar
cells respond differently to the same signal? What
properties of the cell’s internal state affect its
decision? What determines these properties and
their spread in the cell population? What determines
which cell states are stable? Our lab studies these
fundamental questions in two model systems,
using methods from live cell fluorescent imaging,
microfluidics and statistical and computational
analysis.
Web: inachmanlab.com
Research Title
a
c
3D Imaging
EB formation
T=79h
T=87h
T=96h
EB
Gene
EB55
expression
proﬁling for
each EB
b
73h
75h
79h
100um
83.5h
EB57
100um
EB66
um
um
89.5h
94h
96h
EB29
98h
EB15
n=50, r=0.05 (p=0.76)
0.8
150
n=50, r=0.28 (p=0.05)
0.6
85
0.4
80
0.2
75
70
80
i
50
100
Time [Hours]
130
EB Radius [um]
180
0
80
130
EB Radius [um]
180
4
25
80
-20 -10
0
10
20
Time From Onset [Hours]
j
30
85
n=33, r=0.37 (p=0.03)
3
75
70
65
60
55
2
1
80
Onset to peak [Hours]
90
100
35
90
Onset time [Hours]
Onset Time [Hours]
95
70
80
90
Time [Hours]
0
0
g
Bry−GFP Total Points [K#]
1
1
h
2
2
60
f
3
Amplitude [K#]
e
3
Onset Slope [1/h]
d
EB31
115
EB Radius [um]
150
20
15
10
5
0
−5
50
R1
R2
R3
R1
R2
R3
RESEARCHERS
Prof. Abdussalam Azem
Web: https://en-lifesci.tau.ac.il/profile/azema
Research Title
Molecular machines function
1. Demishtein-Zohary, K., Marom, M., Neupert, W., Mokranjac, D.,
Azem, A. (2015) GxxxG Motifs hold the TIM23 Complex Together.
FEBS J. 282, 2178-2186.
2. Nisemblat, S., Yaniv, O., Parnas, A., Frolow, F., Azem, A. (2015). The
crystal structure of the human mitochondrial chaperonin symmetric
football complex. Proc. Natl. Acad. Sci. USA. 112, 6044-6049.
3. Nisemblat, S., Parnas, A., Yaniv, O., Azem, A., Frolow, F. (2014)
Crystallization and structure determination of a symmetrical football
complex of the mammalian mitochondrial Hsp60-Hsp10 chaperonins.
Acta Cryst. F. 70, 116-119.
4. Sharabi, M., Mandelberg, Y., Benayahu, D., Benayahu, Y., Azem, A.,
Haj-Ali, R. (2014) A new class of bio-composite materials of unique
collagen fibers. J. Mech. Behav. Biomed. Mater. 36C, 71-81.
5. Marom, M, Azem, A and Mokranjac, D. (2011) Understanding
the molecular mechanism of protein translocation across the
mitochondrial inner membrane: Still a long way to go. Biochem.
Biophys. Acta (Biomembranes). 1808, 990-1001
For many years, our laboratory has been interested primarily in unraveling
the molecular mechanisms behind the function of two groups of
proteins:
The first is the sophisticated machinery that mitochondria use for
translocating proteins from the cytosol. Most mitochondrial proteins
are encoded in the nuclear genome, synthesized in the cytosol as
preproteins and then imported into mitochondria. Uptake of these
preproteins into the mitochondria is mediated by a number of oligomeric
protein complexes, which are found in various places: the cytosol,
the outer mitochondrial membrane, intermembrane space, the inner
mitochondrial membrane and the mitochondrial
matrix. The translocase of the inner membrane,
TIM23 complex, with its associated proteins, is the
focus of one major project in our laboratory.
The second main topic of our research is the
chaperonin family of proteins - the most well-known
of which are the GroEL and GroES proteins of E.
coli. GroEL (cpn60 or Hsp60) binds with nascent
or stress-denatured proteins and facilitates their
refolding with the assistance of its co-chaperonin
GroES (cpn10 or Hsp10). In mitochondria, Hsp60
mediates the folding of proteins that have been
translocated from the cytosol to the matrix. The
importance of these chaperonins in mitochondria
has been heightened by the discovery of genetic
diseases caused by mutations in these proteins, as
well as their extramitochondrial roles, some related
to cancer development.
Having studied the structure and function of
mitochondrial and chloroplast chaperonins in vitro
for a long time, we recently became interested in
the mechanism behind genetic diseases. Modern
deep-sequencing technologies have facilitated the
identification of mutations responsible for recessive
genetic diseases, and we use this information
to delineate the molecular basis of the disease,
applying a two-pronged approach. We utilize a
yeast model to study the effects of the mutated
protein in a biological system, while also producing
and purifying the mutated protein in vitro, in order
to investigate its properties and its interaction with
other proteins.
RESEARCHERS
Prof. Karen B. Avraham
Web: www.tau.ac.il/~karena
Research Title
Genomics of hereditary hearing loss
A major goal in auditory science is to understand
how the cells of the inner ear develop to provide
the exquisite precision of hearing. The organ of
Corti, which houses the sensory cells of the inner
ear, develops from sensory epithelium derived from
ectoderm. Together with innervation of the sensory
spiral ganglion cells, the auditory system collects
sounds and transforms their mechanical forces
into an electrical signal that functions throughout
our lifetime. At a molecular level, the interactions
of DNA, RNA and proteins of the auditory system
orchestrate a remarkable feat that is summarized
in our ability to hear.
The challenge in auditory science is to determine
which and how a pathogenic variant in a gene or
regulatory element can cause the entire hearing
system to fail. Our group is asking the questions: (1)
What are the genes that lead to hearing loss, and
how are they involved in normal function of the inner
ear? (2) How does regulation of gene expression
govern the pathways that determine inner ear
function, and how do alterations in regulation, on
a genetic and epigenetic level, contribute to the
pathology of deafness?
1. Shefer, S., Gordon, C., Avraham, K.B. and Mintz, M. (2015). Balance
deficit enhances anxiety and balance training decreases anxiety in
vestibular mutant mice. Behav. Brain Res., 276:76-83.
2. Bhonker Y, Abu-Rayyan A, Ushakov U, Amir-Zilberstein A, Shaked
Shivatzki S, Ofer Yizhar-Barnea O, Tal Elkan-Miller T, Einav TayebFligelman E, Kim SM, Landau M, Kanaan K, Chen P, Matsuzaki F,
Sprinzak D, Avraham K.B. (2015). The GPSM2/LGN GoLoco motifs
are essential for hearing. Mamm. Genome, 27:29-46.
RESEARCHERS
Prof. Uri Ashery
Web: http://www.tau.ac.il/lifesci/departments/neuro/members/ashery/ashery.html
Research Title
Molecular mechanisms of synaptic transmission
Our laboratory investigates the functions of key
synaptic proteins in synaptic transmission and
plasticity, both in health and in neurodegenerative
diseases. The lab applies a multidisciplinary
approach, pooling expertise in molecular biology,
electrophysiology, biochemistry, optogenetics, highend imaging and computer-simulation techniques,
to understand how neurons communicate at the
cellular and molecular levels to influence animal
behavior. Recently, we integrated a novel method,
termed super-resolution microscopy, enabling
the detection of protein distribution at singlemolecule 20-nm resolution. Using several superresolution methods (dSTORM, STED) and combining
experimental and computational capabilities, our
group described how the spatial distribution of
synaptic proteins from the SNARE and active zone
families influences synaptic transmission (J. Biol.
Chem. 2012; J. Biol. Chem. 2014; Nat. Commun. 2014).
We are now using this system to investigate how
the alpha synuclein protein forms aggregates, and
to discover the mode of action of specific inhibitors,
such as chemical chaperones and aromatic small
molecules. Work is performed on brain slices,
induced pluripotent stem cells and cell lines.
1. Bar-On D, Wolter S, van de Linde S, Heilemann M, Nudelman G,
Nachliel E, Gutman M, Sauer M, Ashery U. (2012). Super-resolution
Imaging Reveals the Internal Architecture of Nano-sized Syntaxin
Clusters. J Biol Chem. 2012 3;287(32):27158-67
2. Bielopolski, N., Lam, A. D., Bar-On, D., Sauer, M., Stuenkel, E. L., and
Ashery, U. (2014). Differential interaction of tomosyn with syntaxin
and SNAP25 depends on domains in the WD40 beta-propeller core
and determines its inhibitory activity. J Biol Chem 289, 17087-17099.
3. Ehmann, N., van de Linde, S., Alon, A., Ljaschenko, D., Keung, X. Z.,
Holm, T., Rings, A., DiAntonio, A., Hallermann, S., Ashery, U., Heckmann,
M., Sauer, M., and Kittel, R. J. (2014). Quantitative super-resolution
imaging of Bruchpilot distinguishes active zone states. Nat Commun
5, 4650.
RESEARCHERS
Prof. Itai Benhar
Web: http://www.tau.ac.il/lifesci/departments/biotech/members/benhar/benhar.html
Research Title
Targeted nanomedicines
1. Artzy-Schnirman A, Blat D, Talmon Y, Fishler R, Gertman D, Oren R,
Wolchinsky R, Waks T, Benhar I, Eshhar Z, Sivan U, Reiter Y. (2011).
Electrically controlled molecular recognition harnessed to activate
a cellular response. Nano Lett. 11(11):4997-5001.
2. Vaks L, Benhar I. (2011). In vivo characteristics of targeted drugcarrying filamentous bacteriophage nanomedicines. J. Nanobiotech
9:58.
3. Saggy I, Wine Y, Shefet-Carasso L, Nahary L, Georgiou G, Benhar I
(2012) Antibody isolation from immunized animals: comparison
of phage display and antibody discovery via V gene repertoire.
4. Levi O, Tal B, Hileli S, Shapira A, Benhar I, Grabov P, Eliaz N (2016).
Optimization of EGFR high positive cell isolation procedure by
design of experiments methodology. Cytometry B Clin Cytom.
2015 Sep-Oct;88(5):338-47. doi: 10.1002/cyto.b.21246. Epub 201.
5. Halperin A, Shadkchan Y, Pisarevsky E, Szpilman AM, Sandovsky
H, Osherov N, Benhar I (2016). Novel Water-Soluble Amphotericin
B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy. J
Med Chem. 2016 Feb 11;59(3):1197-206.
For several years we have been developing targeted drug-carrying
nanomedicines, based on a core technology of genetically and chemically
engineered virus particles. We developed such guided missiles to treat
devastating diseases, such as life-threatening infections caused by
drug-resistant bacteria, and also for potential cancer therapy. Currently,
we are focusing our efforts on developing treatments of this type for
pathogenic fungi that cause life-threatening lung infections in cystic
fibrosis and transplant patients. In this novel work, the drug carriers
are none other than genetically and chemically engineered viruses.
Usually considered vicious pathogens, viruses can also be helpful to
humans. In particular, viruses named bacteriophages, that attack bacteria,
can be used for killing bacteria resistant to antibiotics, or other cells that
bear disease. Bacteriophages (phages) thrive in bacteria, and in many
cases kill the host bacteria once they have finished multiplying within
it. This ability laid the ground for classical phage
therapy, in which phages that kill disease-causing
bacteria are isolated from their natural habitats.
Our application, however, is totally different, as
we do not rely on the natural ability of the virus
to kill its host. Rather, we regard it as a long and
thin nanoparticle that can be tailored to fulfill a
specific purpose.
Filamentous phages are a family of bacterial viruses
that have only about 10 genes and grow in wellcharacterized hosts - the Gram-negative bacteria.
Structurally, the filamentous phage is a particle of
nanometric dimensions comprising a sheath of
several thousand coat proteins in a helical array,
which, during phage maturation, self-assemble
around a single-stranded circular DNA molecule at
the core. A few minor proteins cap the particle at
each end. Our group presented a novel technology
- related to the field of targeted drug delivery - in
which the phages function as targeted drug-carrying
phage nanoparticles.
For several years now we have been developing new
techniques to genetically modify these viruses to
carry drugs to specific locations in the body, in order
to treat various diseases, such as cancer and fungal
infections. This approach is based on genetically
modifying and chemically manipulating the phages:
the genetic manipulation endows the phages with
the ability to display a host-specificity-conferring
ligand (target-specific peptide, recombinant
antibody or other target-specifying entity) on
their surface. Chemically, the bacteriophages are
conjugated through labile linkages that are subject
to controlled cleavage to a drug. These targeted
drug carrying phage nanoparticles have a large
drug-carrying capacity in excess of ten thousand
drug molecules per target site.
Previously, we evaluated the effectiveness of this
RESEARCHERS
approach for the elimination of pathogenic bacteria and for cancer
therapy. In our current project, we develop such phages to treat
recalcitrant fungal infections. The antibodies in this case are specific
for binding with the pathogenic fungus – Aspergillus fumigatus (AF)
- that causes life-threatening lung infections in immunocompromised
patients. The drug Amphotericin B is to be linked to the phages by
means of chemical conjugation, through a genetically engineered labile
linker, subject to controlled release as a result of proteolytic activity of
the fungal protease Alp1.
At present we are working on conjugating the drug to the phages. To
this end we synthesized PEG conjugates of amphotericin B (AMB), to
make the drug water soluble. In a recently published
article we described the drug properties of these
compounds as free drugs: they are still very potent
as anti fungals, but very much reduced in nonspecific toxicity.
Next we plan to complete the complicated task
of conjugating the drug to the phages, and then
test the efficiency of our drug delivery system in
killing the fungus in culture and in a mouse lung
infection model.
RESEARCHERS
Dr. Noam Shomron
Affiliation: Medicine
Web: www.tau.ac.il/~nshomron
Research Title
Genomics of human diseases
The Shomron research team focuses on the analysis
of genomics, aimed at understanding human
diseases. Combining high-throughput methods and
bioinformatics, our team explores gene regulators,
such as microRNAs, in order to reach a global systems
perspective on the mechanistic roles small RNA
play during disease development.
Among our projects: Identifying microRNAs located
at the intersection of several oncogenes; Controlling
metastatic breast cancer via nanoparticles releasing
microRNAs; Revealing the influence of microRNAs
on pharmacogenomics and personalized medicine;
Exposing pathogens in human tissues based on
deep sequencing of small RNA molecules.
Overall, our team pursues research that aims to
deepen our understanding of the development of
diseases, in order to generate a significant impact
through translating ideas into clinical reality.
1. Isakov O, Perrone M, Shomron N. Exome sequencing analysis: a guide
to disease variant detection. Methods Mol Biol. 2013;1038:137-58.
2. Gilam A, Edry L, Mamluk-Morag E, Bar-Ilan D, Avivi C, Golan D,
Laitman Y, Barshack I, Friedman E, Shomron N. Involvement of IGF1R regulation by miR-515-5p modifies breast cancer risk among
BRCA1 carriers. Breast Cancer Res Treat. 2013 Apr;138(3):753-60.
3. Mor E, Kano S, Colantuoni C, Sawa A, Navon R, Shomron N.
MicroRNA-382 expression is elevated in the olfactory neuroepithelium
of schizophrenia patients. Neurobiol Dis. 2013 Jul;55:1-10.
4. Shomron N. Genetics research: jumping into the deep end of the
pool. Genet Res (Camb). 2013 Feb;95(1):1-3.
5. Isakov O, Ronen R, Kovarsky J, Gabay A, Gan I, Modai S, Shomron
N. Novel insight into the non-coding repertoire through deep
sequencing analysis. NucleicAcids Res. 2012 Jun;40(11):e86.
RESEARCHERS
Dr. Avigdor Eldar
Affiliation: Life Science
Web: http://www6.tau.ac.il/eldar/
Research Title
Elucidating bacterial communication systems
Our main interest is in understanding the design
principles of cooperative behavior in bacteria.
More specifically, we focus on how bacterial
communication (also known as quorum sensing)
is involved in the regulation of cooperation. Our
aim is to elucidate the impact of social structure,
spatial form and phenotypic heterogeneity on the
development of cooperation and its evolution. In
order to study the phenomenon of cooperation
in simple and complex structures we combine
tools from microbiology, genetics, molecular
biology, microscopy and quantitative modeling.
Our main model organisms are the gram-positive
soil bacteria B. subtilis and the gram-negative
pathogen P. aeruginosa. These two organisms
are major model systems of quorum sensing and
biofilm development, allowing us to use their superb
genetic tools and vast knowledge base as a starting
point for our investigation.
1. Avigdor Eldar (2011). Social conflict drives the evolutionary divergence
of quorum sensing. Proceedings of the National Academy of Science,
108 (33): 13635-13640 Partial penetrance facilitates developmental
evolution in bacteria.
2. Avigdor Eldar,Vasant K. Chary, Panos Xenopoulos, Michelle E.
Fontes,Oliver C. Losón, Jonathan Dworkin, Patrick J. Piggot PJ, Michael
B. Elowitz. (2009). Self-Enhanced Ligand Degradation Underlies
Robustness of Morphogen Gradients Nature, 460(7254):510-4
3. Avigdor Eldar, Dalia Rosin, Ben-Zion Shilo and Naama Barkai. (2003).
Robustness of the BMP morphogen gradient in Drosophila embryonic
patterning Developmental Cell, Vol 5, 635-646
4. Avigdor Eldar, Ruslan Dorfman, Daniel Weiss, Hilary Ashe, Ben-Zion
Shilo and Naama Barkai. (2002). Functional Roles for Noise in Genetic
Circuits. Nature 419, 304-308 (2002).
5. Avigdor Eldar and Michael Elowitz. (2010). Nature, 467(7312):167-173.
RESEARCHERS
Prof. Roy Beck
Affiliation: Physics
Web: http://www6.tau.ac.il/beck/
Research Title
Nanoscale biophysics
1. G. Jacoby, K. Cohen, K. Barkan, Y. Talmon, D. Peer, R. Beck, Predetermined
and controlled metastable phase transition in lipid-based particles.
Scientific Reports 5, 9481 (2015). DOI: 10.1038/srep09481
2. S. Pregent, A. Lichtenstein, R. Avinery, A. Laser-Azogui, F. Patolsky, R.
Beck, Probing the interactions of intrinsically disordered proteins
using nanoparticle tags. Nano Letters (2015). DOI: 10.1021/acs.
nanolett.5b00073.
3. M. Kornreich, E. Malka-Gibor, A. Laser-Azogui, O. Doron, H. Herrmann,
R. Beck, Composite bottlebrush mechanics: α-Internexin fine-tunes
neurofilament network properties. Soft Matter 11, 5839-5849 (2015).
DOI: 10.1039/C5SM00662G
4. L. Almagor, R. Avinery, J. Hirsh, R. Beck, Structural flexibility of CaV
1.2 and CaV 2.2 proximal linker fragments in solution, Biophysical
Journal 104, 2392-2400 (2013), DOI: 10.1016/j.bpj.2013.04.034,
PMID: 23746511
5. R. Beck, J. Deek, J.B. Jones, C.R. Safinya, Gel Expanded to Gel
Condensed Transition in Neurofilament Networks revealed by Direct
Force Measurements, Nature Materials 9, 40-46 (2010),PMID:19915555
In many significant biological functions the four basic building
blocks (proteins, lipids, sugars and nucleic acids) aggregate to form
supramolecular structures and assemblies. The forces and interactions
responsible for these assemblies are composed of a set of interactions
with energy scales ranging from thermal fluctuations (a few KT) to
specific covalent bonds (100s of KT). Relevant length scales in biological
systems also span many orders of magnitude, from the single amino
acid through polypeptide chains, protein complexes and organelles, all
the way up to cells and organs. These different scales present enormous
challenges, both experimentally and theoretically.
In order to properly study biological systems and
the interactions within them, it is important to
have complementary techniques covering different
length and energy scales, with proximity to their
natural environment. In our laboratory we purify the
subunit biological building blocks, using a variety
of state-of-the-art biochemical and molecular
techniques. We then reassemble them in precise
conditions, to extract the underlying physics
pertaining to their supramolecular forces, dynamics
and steady-state structures - particularly as they
appear in healthy and diseased states.
We use small and wide angle x-ray scattering (WAXS
& SAXS) to cover length scales from 0.1-100 nm.
These techniques are suitable for measuring weak
scattering from biological systems in their natural
environment. Detailed analysis and advanced
computational techniques are regularly used
to convert the reciprocal space into real-space
structures, and enable studies on the nature of
the interactions within the biological assemblies.
SAXS, in particular, provides a ready means for
determining inter-filament spacing and interactions.
Recent advances in solid-state type x-ray detectors
and high-flux microfocus x-ray sources allow
investigation of dynamic structural events, as well
as highly penetrated measurements. Conveniently,
these approaches do not require staining or other
modifications, and thus do not perturb our system,
allowing easier access to the supramolecular forces
underlying self-assembly, and simplifying data
analysis.
RESEARCHERS
Dr. Yael Roichman
Affiliation: Chemistry
Web: http://www.tau.ac.il/~roichman/
Research Title
Experimental studies of soft matter with holographic optical
tweezers
In our group we are interested in understanding
the principles governing the behavior of systems
out of thermal equilibrium. To this end we use
a combination of optical imaging and optical
manipulation to probe and image soft materials and
complex fluids. We believe that by studying in detail
many model systems far from thermal equilibrium,
we will be able to see emergent universalities. In
the past few years we have studied two different
systems driven out of equilibrium in different ways:
optically driven colloidal suspensions, and in-vitro
cytoskeleton networks containing molecular motors.
Technically, the experimental work in the group
is based on video microscopy, particle tracking
and image velocimetry for studying the dynamics
and kinetics of particles in our model systems, and
microrheology for characterizing their mechanical
properties. In addition, we develop optical imaging
techniques with improved resolution and speed,
and combine various 3D imaging techniques with
optical trapping and manipulation.
1. Diffusion of a nano-wire through an obstacle field, Dror Kasimov,
Tamir Admon, and Yael Roichman, PRE in press (2016)
2. Tomographic phase microscopy with 180o rotation of live cells in
suspension by holographic optical tweezers, Mor Habaza, Barak
Gilboa, Yael Roichman, and Natan T. Shaked, Optics Lett., 40, 18811884 (2015).
3. Viscoelastic respone of a complex fluid at intermediate distances,
Adar Sonn-Segev, Anne bernheim-Groswasser, Haim Diamant, and
Yael Roichman, Phys. Rev. Lett., 112, 088301 (2014).
4. Independent and simultaneous three-dimensional optical trapping
and imaging. Maya Yevnin, Dror Kasimov, Yael Gluckman, Yuval
Ebenstein, and Yael Roichman, Biomedical Optics Express, 4, 20872094 (2013).
5. Hydrodynamic Pair Attractions between Driven Colloidal Particles,
Yulia Sokolov, Derek Frydel, David G. Grier, Haim Diamant, and Yael
Roichman, Phys. Rev. Lett., 107, 158302, (2011).
RESEARCHERS
Dr. Yair Shokef
Affiliation: Mechanical Engineering
Web: http://shokef.tau.ac.il/
Research Title
Non-equilibrium statistical mechanics of soft matter
1. A. Ghosh, E. Teomy, and Y. Shokef, Jamming percolation in three
dimensions, Europhysics Letters 106, 16003 (2014).
2. E. Teomy and Y. Shokef Finite-density effects in the Fredrickson-Andersen
and Kob-Andersen kinetically-constrained models, The Journal of
Chemical Physics 141, 064110 (2014).
3. Y. Shokef and S.A. Safran, Scaling laws for the response of nonlinear
elastic media with implications for cell mechanics, Physical Review
Letters 108, 178103 (2012).
4. Y. Shokef, A. Souslov, and T.C. Lubensky, Order-by-disorder in the
antiferromagnetic Ising model on an elastic triangular lattice, Proceedings
of the National Academy of Sciences of the USA 108, 11804 (2011).
5. Y. Han, Y. Shokef, A.M. Alsayed, P. Yunker, T.C. Lubensky, and A.G. Yodh,
Geometric frustration in buckled colloidal monolayers, Nature 456,
898 (2008).
Our group conducts theoretical research into the dynamical behavior of soft
materials, using models and concepts inspired by recent developments in
the statistical mechanics of systems far from thermodynamic equilibrium.
Many soft systems encountered in everyday life, such as glasses, colloidal
suspensions (ink), granular media (sand), emulsions (milk) and foams
(shaving cream), as well as most biological systems, are very far from
thermal equilibrium. Even though they are in close contact with a thermal
environment, they are either (i) strongly driven by mechanical or biological
forces with a perpetual current of energy, from the driving source through
the system and out into the dissipative environment, or (ii) they fall into
metastable glassy states and fail to equilibrate with their surroundings. The
typical energy scales of fluctuation in a sheared colloid, in the membrane of a
red blood cell, or in a solution with bacteria swimming in it, are considerably
higher than the thermal energy. More dramatically, for a pile of sand or
flour, thermal energy is negligible compared to the energy required for
a single grain to overcome gravity and hop over one of its neighbors.
On top of the compelling biological and industrial interests in such
materials, soft matter systems are useful as mesoscopic models of molecular
systems. Nano-, micro- or millimeter- scale droplets, colloids and grains
arrange themselves and behave similarly to atoms
and molecules comprising materials found in nature.
However, colloids and grains are large enough, and
move slowly enough, to allow experiments that directly
show us their dynamics at the single-particle level. The
analogy with these systems thus enables us to visualize
microscopic processes governing the macroscopic
characteristics and dynamic properties of complex
materials, which are otherwise very poorly understood.
Our current research efforts focus on two main topics:
jammed matter and active matter.
The first involves using lattice-based models to
study disordered soft materials such as powders,
foams, colloids and glasses - the dynamics of which
are all extremely slow and cooperative. Some of
these models jam and remain disordered, due to
geometric frustration - namely the inability of a system
to simultaneously satisfy all of its local constraints,
making it difficult for it to reach a global optimum
which minimizes the relevant free energy. Other
models, studied analytically and numerically, consist
of kinetically constrained dynamics. Here the geometry
is implemented effectively by directly defining which
dynamical moves are allowed and which are forbidden,
in ways that may generate jamming similar to that
found in more complicated models.
The second line of research includes the study of
fluctuations generated in biological systems due
to the presence of molecular motors within them.
These motors consume chemical energy and generate
mechanical forces which drive the system out of
thermodynamic equilibrium. Moreover, biological
materials have a very nonlinear mechanical response,
and therefore the macroscopic mechanical properties
of biological systems are very different from those
of passive materials. Our activity along this avenue
includes the use of stochastic models for the dynamics
in conjunction with geometrical descriptions of the
nonlinear, finite-deformation elasticity of biological
materials.
RESEARCHERS
Prof. Tamir Tuller
Affiliation: Bio-medical Engineering
Web: http://www.cs.tau.ac.il/~tamirtul/
Research Title
Deciphering, modeling and engineering gene expression
Gene expression is the process by which information
encoded in the genome is used to synthesize
intra-cellular molecules such as proteins, which
are involved in all intra-cellular activities. The
genetic code is a table that translates triplets of
nucleotides (alphabet of the mRNA/DNA) to amino
acids (alphabet of proteins).
There is, however, redundancy in the genetic code:
61 triplets of nucleotides actually code only 20 amino
acids. In this redundancy and also in the non-coding
regions, some aspects of gene expression - e.g. the
rate at which the proteins will be generated - can
be (at least partially) encoded.
Our group is working on: 1) Deciphering how gene
expression is usually encoded in the transcript itself,
affecting its evolution; 2) Developing and analyzing
computational/ mathematical/statistical/biophysical
models that represent these rules; 3) Developing
novel approaches to computer-aided design (CAD),
and engineering gene expression based on these
models.
1. Dana, A., Tuller, T. (2014) The effect of tRNA levels on decoding
times of mRNA codons. Nucleic Acids Res. Jul 23.
2. Zur,H., Tuller, T.(2014). Exploiting Hidden Information Interleaved
in the Redundancy of the Genetic Code without Prior Knowledge.
Bioinformatics. Nov 29. pii: btu797.
3. Diament,A., Pinter,R.Y., Tuller, T.(2014). Three-dimensional eukaryotic
genomic organization is strongly correlated with codon usage
expression and function. Nature Communications. 16 Dec 2014.
4. Ben-Yehezkel, T., Atar,S., Zur,H., Diament,A., Goz,E., Marx,T., Cohen,R.,
Dana,A., Feldman,A., Shapiro,E., Tuller, T. (2015) Rationally designed,
heterologous S. cerevisiae transcripts expose novel expression
determinants. RNA Biol. 12(9):972-84.
5. Raveh, A., Margaliot, M., Sontag, E.D. Tuller,T. (2016). A model for
competition for ribosomes in the cell. J. R. Soc. Interface. Mar;13(116).
RESEARCHERS
Dr. Sharly Fleischer
Web: https://sites.google.com/site/terahertzandultrafastlab/
Research Title
Ultrafast terahertz and optical coherent control of molecules
Just as light is affected by the matter it interacts with
in traditional spectroscopy, the state of matter can
also be altered by light, and coherently driven to
yield a desired goal. This field of research is known
as ‘coherent control’.
Interested in both these mutually complementary
processes, we use intense femtosecond light fields
in both the terahertz range (THz fields, 10^12 Hz)
and the visible/near-IR range (optical fields, 10^15
Hz) to coherently control and spectroscopically
study the dynamics of molecules.
We develop new control schemes based on
combined excitation by THz and optical fields,
acting as two distinct molecular handles. We utilize
these fields to induce unique angular distributions
in molecular ensembles, and then study them
via advanced ultrafast spectroscopic methods.
With the help of intense light fields, we wish to
control and study molecules of increasing size and
complexity, and ultimately apply these methods
to big molecules and nanostructures of chemical
and biological interest.
1. Kallush, S., and Fleischer, S. (2015). Orientation dynamics of asymmetric
rotors using random phase wave functions, Phys. Rev. A 91, 063420.
2. Fleischer, S., Field, R.W, and Nelson, K. (2014), From populations to
coherences and back again – a new insight about rotating dipoles,
arXiv:1405.7025.of the Genetic Code without Prior Knowledge.
Bioinformatics. Nov 29. pii: btu797.
3. Fleischer, S., Field, R.W, and Nelson, K. (2012). Commensurate two
quantum coherences induced by time delayed THz fields, Phys.
Rev. Lett. 109, 123603.
4. Fleischer, S., Zhou, Y., Field, R.W, and Nelson, K. (2011). Molecular
orientation and alignment by intense single-cycle THz pulses, Phys.
Rev. Lett. 107, 163603.
5. Fleischer, S., Averbukh, I.Sh., and Prior, Y., (2007). Selective Alignment
of Molecular Spin Isomers, Phys. Rev. Lett. 99, 093002.
RESEARCHERS
Prof. Eli Eisenberg
Web: http://www.tau.ac.il/~elieis
Research Title
Computational analysis of RNA expression data, focusing on
RNA editing
We use the bioinformatic approach and statistical
modeling to analyze RNA expression data. In
particular, we have developed methods for
identification, quantification and analysis of A-to-I
RNA editing, an endogenous process in which the
RNA is enzymatically modified from its genomic
blueprint.
1. Paz-Yaacov, L. Bazak, H.T.Porath, I. Buchumenski, M. Danan-Gotthold,
B.A. Knisbacher, E. Eisenberg and E.Y. Levanon. Elevated RNA Editing
Activity is a Major Contributor to Transcriptomic Diversity in Tumors,
Cell Reports 13, 267-276 (2015)
2. S. Alon, S.C. Garrett, E.Y. Levanon, S. Olson, B.R. Graveley, J.J.C. Rosenthal
and E. Eisenberg. The majority of transcripts in the squid nervous
system are extensively recoded by A-to-I RNA editing, eLife 4,
e05198 (2015).
3. L. Bazak, A. Haviv, M. Barak, J. Jacob-Hirsch, P. Deng, R. Zhang, F.J.
Isaacs, G. Rechavi, J.B. Li, E. Eisenberg and E.Y. Levanon. A-to-I RNA
editing occurs at over a hundred million genomic sites, located in
a majority of human genes, Genome Research 24, 365-376 (2014).
4. E. Eisenberg and E.Y. Levanon. Human housekeeping genes, revisited,
Trends in Genetics, 29, 569-574 (2013).
5. S. Alon, E. Mor, F. Vigneault, G. Church, F. Locatelli, F. Galeano, A.
Gallo, N. Shomron and E. Eisenberg, Systematic identification of
edited microRNAs in the human brain Genome Research, 22, 15331540 (2012).
RESEARCHERS
Dr. Amir Goldbourt
Web: kuwari.tau.ac.il
Research Title
Biomolecular solid state NMR
Research in our group focuses on developing and
applying magic-angle spinning solid state NMR
for the study of complex systems, with a particular
emphasis on structural virology.
One example is the family of filamentous
bacteriophages: bacteria-infecting viruses that
share a similar virion structure and life cycle. The
virion is composed of a circular ssDNA wrapped by
thousands of similar copies of a major coat protein,
with several different minor coat proteins at both
ends. Our group prepares, purifies and uses magicangle spinning NMR techniques to characterize
the structure of various phages in atomic-detailed
resolution.
Another area of interest is the NMR of metal ions,
which play a crucial role in the function of enzymes.
Low occupancies, dynamics and other obstacles
often hinder the detailed characterization of such
sites, and our group addresses this challenge. We
develop and apply techniques for characterizing the
structural environment of metal ions such as 11B, 51V,
7
Li, 23Na and other similar nuclei exhibiting a large
anisotropic interaction in the magnetic field. For
example: lithium salts have been known as mood
stabilizing drugs for bipolar disorder patients for
over 50 years. It was hypothesized that lithium exerts
its therapeutic effect by binding with the enzyme
myo-inositol monophosphatase (IMPase), thereby
reducing inositol levels in the blood and diminishing
the hyperactive phosphatidyl-inositol cell signaling
pathway. Other targets of lithium have also been
proposed. Since lithium is mostly spectroscopically
silent, we use magic-angle spinning NMR techniques
to directly observe and characterize lithium’s binding
sites in its drug targets.
1. O. Morag, G. Abramov, A. Goldbourt (2014). Complete chemical
shift assignment of the ssDNA in the filamentous bacteriophage
fd reports on its conformation and on its interface with the capsid
shell, J. Am. Chem. Soc. 136, 2292-2301.
2. E. Nimerovsky, R. Gupta, J. Yehl, M. Li, T. Polenova, A. Goldbourt
(2014). Phase-modulated LA-REDOR: A robust, accurate and efficient
solid-state NMR technique for distance measurements between
a spin-1/2 and a quadrupole spin., J. Magn. Reson. 244, 107-113.
3. O. Morag, N. G. Sgourakis, D. Baker, A. Goldbourt (2015). The NMRRosetta capsid model of M13 bacteriophage reveals a quadrupoled
hydrophonic packing epitope, Proc. Natl. Acad. Sci. 112(4), 971-976.
4. L. Avram, A. Goldbourt, Y. Cohen (2016). Hexameric capsules studied
by magic angle spinning solid state NMR Spectroscopy: Identifying
solvent molecules in pyrogallol[4]arene capsules. Angew. Chem.
Int. Ed. 55(3), 904-907.
5. H. Ivanir, E. Nimerovsky, PK Madhu, A. Goldbourt (2015). Site-resolved
backbone and side-chain intermediate dynamics in a carbohydratebinding module protein studied by magic-angle spinning NMR.
Chem. Eur. J., 21, 10778–10785.
RESEARCHERS
Prof. David Andelman
Web: www.tau.ac.il/~andelman
Research Title
Theory of soft and biological matter
We specialize in studying soft matter and biological
systems, in collaboration with several experimental
teams worldwide. In particular, we explore the
properties of self-assembling polymers, and ways
to manipulate them at patterned surfaces and in thin
film geometries, in relation with nanolithography.
Another line of research is the exploration of bioand soft matter systems in which charges play an
important role. We investigate ionic liquids at charged
interfaces and membranes, and the response of
ionic solutions and charged macromolecules to
external electric fields.
1. Lamellar Diblock Copolymers on Rough Substrates: Self-consistent
Field Theory Studies, X. K. Man, J. Tang, P. Zhou, D. Yan, and D.
Andelman, Macromolecules 48, 7689-7697 (2015). http://arxiv.
org/abs/1506.06854.
2. Contact Angle Saturation in Electrowetting: Injection of Ions into the
surrounding Media, T. Yamamoto, M. Doi, and D. Andelman, Europhys.
Lett. 112, 56001.1-6 (2015). http://arxiv.org/abs/1510.00613.
3. Correlated Lateral Phase Separations in Stacks of Lipid Membranes, T.
Hoshino, S. Komura, and D. Andelman, J. Chem. Phys. 143, 243124.19 (2015). http://arxiv.org/abs/1508.03942.
4. Surface Tension of Electrolyte Interfaces: Ionic Specificity within a Field
Theory Approach, T. Markovich, D. Andelman, and R. Podgornik, J.
Chem. Phys. 142, 044702.1-13 (2015). http://arxiv.org/abs/1411.5222.
5. Charge-induced Phase Separation in Lipid Membranes, H. Himeno,
N. Shimokawa, S. Komura, D. Andelman, T. Hamada, and M. Takagia,
Soft Matter 10, 7959-7967 (2014). http://arxiv.org/abs/1405.4650.
RESEARCHERS
Prof. Natan Shaked
Affiliation: Bio-medical Engineering
Web: www.eng.tau.ac.il/~omni
Research Title
Biomedical optical microscopy, nanoscopy and interferometry
We are interested in the development of
interferometric imaging methods for nano-profiling
of thin elements, such as live biological cells in vitro,
lithography processes and semiconductor wafers.
Specifically, we develop interferometric and
tomographic phase microscopy methods that
can operate outside of the optical lab, in instable
environments. By using compact, low-coherence,
common-path, off-axis interferometric modules, we
obtain 3D imaging of live biological cells without
external labeling, and record the optical path
delay of light passing through the sample with
sub-nanometer accuracy. Furthermore, since these
interferometric methods are very sensitive to local
refractive-index changes, we develop plasmonic
nanoparticles, which induce local heat changes
due to photothermal excitation, as new contrast
agents in live cells.
1. P. Girshovitz and N. T. Shaked, Doubling the field of view in off-axis
low-coherence interferometric imaging, Nature – Light: Science
and Applications (Nature LSA), Vol. 3, e151, pp. 1-9, 2014.
2. P. Girshovitz and N. T. Shaked, Compact and portable low-coherence
interferometer with off-axis geometry for quantitative phase
microscopy and nanoscopy, Optics Express, Vol. 21, Issue 5, pp.
5701-5714, 2013.
3. M. Habaza, B. Gilboa, Y. Roichman, and N. T. Shaked, Tomographic
phase microscopy with 180° rotation of live cells in suspension by
holographic optical tweezers, Optics Letters, Vol. 40, Issue 8, pp.
1881-1884, 2015.
4. O. Blum and N. T. Shaked, “Prediction of photothermal phase
signatures from arbitrary plasmonic nanoparticles and experimental
verification, Nature – Light: Science and Applications (Nature LSA),
Vol. 4, e322, pp. 1-8, 2015.
5. N. Turko, I. Barnea, O. Blum, R. Korenstein, and N. T. Shaked, Detection
and controlled depletion of cancer cells using photothermal phase
microscopy, Journal of Biophotonics, Vol. 8, Issue 9, pp. 755-763, 2015.
RESEARCHERS
Prof. Yael Hanein
Affiliation: Electrical Engineering
Web: nano.tau.ac.il/hanein
Research Title
Neuro Engineering
The primary focus of our research is electronic devices
for the recording and controlled stimulation of
brain signals. These devices are designed to address
neurological disorders which cannot be treated with
contemporary drugs. Specifically, a nanomaterialbased artificial retina implant with outstanding
performance was recently produced, offering a
promising solution for blindness caused by retinal
degeneration - a condition which afflicts millions
of people worldwide. We are also developing skin
electrode arrays for reliably recording physiological
signals from humans.
1. Lilach Bareket, Nir Waiskopf, David Rand, Gur Lubin, Moshe David-Pur,
Jacob Ben-Dov, Soumyendu Roy, Cyril Eleftheriou, Evelyne Sernagor,
Ori Cheshnovsky, Uri Banin, Yael Hanein, (2014) Semiconductor
Nanorod-Carbon Nanotube Biomimetic Films for Wire-Free PhotoStimulation of Blind Retinas, Nano Letters, 14 (11), pp 66856692
DOI: 10.1021/nl5034304.
2. Vini Gautam, David Rand, Yael Hanein and K.S. Narayan, (2013) A
polymer optoelectronic interface provides visual cues to a blind
retina, Advanced Materials, 10.1002/adma.201304368.
3. Yuval Yifat, Michal Eitan, Zeev Iluz, Yael Hanein, Amir Boag, Jacob
Scheuer, (2014) Highly efficcient and broadband wide-angle
Holography Using Patch-Dipole Nano-antenna Reflect arrays, Nano
Letters, 14 (5), 24852490, 2014.
4. David-Pur M1, Bareket-Keren L, Beit-Yaakov G, Raz-Prag D, Hanein Y.
(2014) All-carbon-nanotube flexible multi-electrode array for neuronal
recording and stimulation. Biomed Microdevices.16(1):43-53. doi:
10.1007/s10544-013-9804-6.
5. Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pitta,
Eshel Ben Jacob, Hugues Berry, and Yael Hanein, Glutamate Mediated
Astrocytic Filtering of Neuronal Activity (2014), PLOS Computational
Biology, DOI: 10.1371/journal.pcbi.1003964.
RESEARCHERS
Prof. Slava Krylov
Affiliation: Mechanical Engineering
Web: www.eng.tau.ac.il/~vadis
Research Title
Design and modeling of micro and nano systems
1. J. Shklovsky, L. Engel, Y. Sverdlov, Y. Shacham-Diamand, S. Krylov,NanoImprinting Lithography of P(VDF-TrFE-CFE) for Flexible Freestanding
MEMS Devices, Microelectronic Engineering, 100, 41-46, 2012.
2. Y. Gerson, D. Schreiber, H. Grau, and S. Krylov, Meso Scale MEMS
Inertial Switch Fabricated using Electroplated Metal on Insulator
(MOI) Process, J. Micromech. Microeng., 24, pap. 025008, 2014.
3. S. Krylov, S. Lulinsky, B. R. Ilic, I. Schneider, Collective Dynamics
and Pattern Switching in an Array of Parametrically Excited Micro
Cantilevers Interacting Through Fringing Electrostatic Fields, Applied
Physics Letters, 105, 071909, 2014.
4. L. Medina, R. Gilat, B.R. Ilic, S. Krylov, Experimental Investigation of The
Snap-Through Buckling of Electrostatically Actuated Initially Curved
Pre-Stressed Microbeams, Sensors and Actuators A, 220, 323–332, 2014.
5. Y. Borisenkov, M. Kholmyansky, S. Krylov, A. Liberzon and A.
Tsinober, Multi-Array Micromachined Probe for Turbulence
Measurements Assembled of Suspended Hot-Film Sensors, IEEE
J. of Microelectromechanical Systems, 24(5), pp. 1503-1509, 2015.
Our research combines theoretical, experimental and applied aspects in
the area of modeling, design, fabrication and characterization of microand nanoelectromechanical systems (MEMS/NEMS). Our efforts focus
on the development of new approaches to actuation and sensing and
their implementation in applications, as well as the study of the typically
nonlinear electromechanical phenomena in microscale structures. A
better understanding of physical phenomena, gained through extensive
investigation, lays the foundation for the possible development of
new designs and operational concepts for micro and nano devices.
The dynamics and stability of micro- and nanostructures is one
central direction of our current activity. One of the distinguishing
features of electrostatically, magnetically or electro-thermally actuated
microstructures is that they are inherently nonlinear, and can become
unstable. Our research sheds light on the dynamic behavior and stability
of microstructures, and inspires a generation of new concepts for using
these phenomena in applications.
Over the last several years, parametrically excited
microstructures were an important part of research
in our lab. In electrostatic devices the actuation
forces are typically time- and configurationdependent functions that modulate the effective
stiffness, and can result in parametric excitation.
Our group has developed and investigated several
unusual approaches to the parametric excitation
of microstructures.
The insights gained from the investigation of
microstructures, along with the exploration of
new actuation and sensing principles, serve as
a basis for implementing these approaches in
applications. The development of new concepts
of sensors in general, and of inertial sensors (angular
rate sensors and accelerometers) in particular, is
essentially based on the results of more fundamental
theoretical and experimental research. Recently we
developed a micro accelerometer incorporating
bistable elements and based on stability boundaries
monitoring. The device was fabricated at TAU and
its functionality was demonstrated.
One of the most promising directions today is the
use of polymeric materials in MEMS/NEMS. While
well-established technologies based on silicon as
a main structural material are widely used, and
have been successfully commercialized, they are
less suitable for implementation in medical micro
devices. In addition, polymeric MEMS devices can
be naturally integrated with flexible electronics to
form a unified sensing platform. In this context, our
group (in collaboration with Prof. Yosi Shacham),
is currently developing a generic technology
based on the design, fabrication and integration
of miniature devices fabricated from electroactive
or/and conductive polymers and electroactive gels.
Recently these endeavors were extended to the
implementation of 3D printing techniques for
fabrication of micro devices.
RESEARCHERS
Prof. Gil Rosenman
Web: http://www.eng.tau.ac.il/~gilr
Research Title
Physical properties of bioinspired nanomaterials
Ultrashort aromatic and aliphatic di- and tripeptide
biomolecular nanostructures of different origin and
native conformation at the nanoscale are studied
by monitoring their basic physical properties
during a thermally induced phase transition. We
show that this fundamental process, found by us
in bioorganic systems, is governed by the thermally
activated reconformation of biomolecules, or their
spatial reconfiguration. Regardless of the origin of
di- and tripeptides and their native architecture, the
phase transition takes place by full refolding into
another similar, irreversible, and thermodynamically
stable fiber-like nanowire morphology. In
this new supramolecular arrangement, newly
observed bioorganic nanodots, with β-sheet
structure and deep reconstruction found at all
levels (molecular, electronic, peptide secondary
structure, morphological, etc.) generate new
physical properties and the appearance of blue/
green photoluminescence.
1. S. Semin, A. van Etteger, N. Amdursky, L. Kulyuk, S. Lavrov, A. Sigov,
E. Mishina, G. Rosenman, and Th. Rasing, (2015). Strong ThermoInduced Single And Two-Photon Green Luminescence In SelfOrganized Peptide Microtubes, Small, 11, 1156–1160.
2. A. Handelman, G. Shalev, G. Rosenman, Symmetry of Bioinspired
Peptide (2015). Nanostructures and Their Basic Physical Properties,
Israel Journal of Chemistry, 55, 637–644.
3. A. Handelman, N.Kuritz, A. Natan and Gil Rosenman, (2016).
Reconstructive Phase Transition in Ultrashort Peptide Nanostructures
and Induced Visible Fluorescence, Invited Feature Article, Langmuir,
32 (12), 2847–2862.
4. A. Handelman, B. Apter, N.Turko and Gil Rosenman. (2016).
Linear and Nonlinear Optical Waveguiding Effects in Bio-inspired
Diphenylalanine Peptide Nanotubes, Acta Biomater, 30, 72–77.
5. A.Handelman, S. Lavrov, A. Kudryavtsev, S. Semin, E. Mishina and
G.Rosenman, Nonlinear Optical Phenomena in Bioinspired Peptide
Nanostructures and Optical Waveguide properties ,Review paper,
Encyclopedia of Nanoscience and Nanotechnology, 10-volume set.
RESEARCHERS
Dr. Yuval Ebenstein
Web: http:// www.nanobiophotonix.com
Research Title
Single-molecule genomics
Our lab specializes in many areas of optical imaging
and spectroscopy, with emphasis on single-molecule
detection and the development of imagingbased techniques. Our research focuses on the
application of novel imaging and optical detection
approaches to genomic studies and biomarker
detection. We develop new spectroscopy and
microscopy methodologies that combine advanced
optics with tools and reagents from the realm of
nanotechnology. In addition, we have great interest
in developing unique biochemistries for genomic
analysis, based on chemo-enzymatic reactions.
1. Ebenstein, Y, Y. Michaeli, T. Shahal, D. Torchinsky, A. Grunwald, R. Hoch,
and Optical detection of epigenetic marks: Sensitive quantification
and direct imaging of individual hydroxymethylcytosine bases.
Chem. Commun., (2013) 49 (77), 8599 - 8601
2. Ebenstein Y., M. Levy-Sakin, Beyond Sequencing: Optical mapping
of DNA in the Age of Nanotechnology and Nanoscopy. Current
Opinion in Biotechnology (2013) 24, (4), 690-698.
3. Ebenstein, Y., Weiss, S., Levy-Sakin M., Grunwald A., Kim, S., Gottfried,
A., Lin, R.R., Dertinger, T., Kim, A.S., Chung, S., Colyer, R.A., Weinhold,
E., Towards Single-Molecule Optical Mapping of the Epigenome.
ACS Nano, (2014) 8, (1), 14-26.
4. Yuval Ebenstein, Jeremy Don, Shahar Zirkin, Sivan Fishman, Hila
Sharim, Yael Michaeli, Lighting Up Individual DNA Damage Sites by
In Vitro Repair Synthesis. JACS (2014), 136, (21), 7771–7776.
5. Ting F. Zhu, Yuval Ebenstein, Chunbo Lou, Wenjun Jiang, Xuejin Zhao,
Tslil Gabrieli, Cas9-Assisted Targeting of CHromosome segments
(CATCH) enables one-step targeted cloning of large gene clusters.
Nat.Comm., (2015).
RESEARCHERS
Prof. Yosi Shacham
Web: eng.tau.ac.il/~yosish
Research Title
Interconnect micro and nano fabrication
1. Yoetz-Kopelman, T., Dror, Y., Shacham-Diamand, Y., & Freeman,
A. “Cells-on-beads”: A novel immobilization approach for the
construction of whole-Cell amperometric biosensors. Sensors
and Actuators B: Chemical, (2016).
2. Ram, Y., Yoetz-Kopelman, T., Dror, Y., Freeman, A., & Shacham-Diamand,
Y. (2016). Impact of Molecular Surface Charge on Biosensing by
Electrochemical Impedance Spectroscopy. Electrochimica Acta.‫‏‬
3. Hemed, N. M., Convertino, A., & Shacham-Diamand, Y. (2016).
Investigation of Functionalized Silicon Nanowires by Self-Assembled
Monolayer. Applied Surface Science. ‫(‏‬Accepted for publication).
4. Yoetz-Kopelman, T., Porat-Ophir, C., Shacham-Diamand, Y., & Freeman,
A. (2016). Whole-cell amperometric biosensor for screening of
cytochrome P450 inhibitors. Sensors and Actuators B: Chemical,
223, 392-399.‫‏‬
5. Feiner, R., Engel, L., Fleischer, S., Malki, M., Gal, I., Shapira, A., ShachamDiamand Y. & Dvir, T., Engineered hybrid cardiac patches with
multifunctional electronics for online monitoring and regulation
of tissue function. Nature materials. 2016.
Cu interconnect requires barrier layers to prevent Cu diffusion into the
dielectrics and the Si substrate. Cu lines also require capping layers
to prevent oxidation and improve reliability, by reducing Cu surface
electromigration - mostly at the top interface where the Cu was exposed
to chemical mechanical polishing during the “Dual Damascene” fully
embedded metal positive patterning process. Electroless nickel and
cobalt alloys were found to be very useful as barrier
and capping layers for Cu metallization. The most
useful barrier and capping layers were made of
alloys of cobalt and nickel with refractory metals
(tungsten, molybdenum or rhenium) and also with
phosphorus or boron.
The coupling of living cells, serving as sensor
elements, with microelectronic devices, provides
novel opportunities for biosensors performing as
stable, sensitive, specific and accurate electronic
devices. Electroless Deposition methods, in
which metal cations are chemically reduced by a
reducing agent into a deposited metallic film, may
provide a new and effective tool for the coupling
of biological activities and electronic circuits.
Electrical characteristics (conductivity) and structure
preservation are achieved by coating the structure
with a thin metal film.
The main goal of our research is to study the new
concept of integration of metallized whole cells
with electronically interfacing biosensors. In order
to miniaturize the biosensors we want to work
with a single cell or a small number of cells located
within a small area on a chip. To achieve this, we
must be able to control the location of the cell on
the electrode, and to provide electrical contact
between cell and electrode. We hypothesize that
by using cells metallized by electroless deposition
we can achieve both goals.
RESEARCHERS
Prof. Shachar Richter
Affiliation: Materials Science and Engineering
Web: http://www.eng.tau.ac.il/~srichter/
Research Title
Bio and molecular electronics
In our group we adopt a bottom-up approach
to develop and explore various properties of
nanomaterials, self-assembled monolayers and
thin films. We start from the molecular level, and
use molecular synthesis to form the desired basic
structures which, in the next stage, are incorporated
into our novel devices. Examples include doped
proteins, chiral nanostructures and plasmonic
materials.
Our compounds can be formed in self-assembly
fashion (the self-assembled monolayers of doped
proteins), as thin films (white-emitting coating
for white LEDs) or as standalone materials
(biodegradable plastics and hydrogels made from
renewable materials).
In order to explore the properties of these materials
we have developed new types of nano-devices,
including nano-vertical transistors and circuits, solar
cells and light emitting materials. We have also
developed novel nanolithography techniques, some
of which are currently undergoing commercialization
processes.
Our group includes students, postdocs and
engineers from various disciplines - including
chemistry, physics, biology and engineering.
1. Sidelman, Noam, Moshik Cohen, Anke Kolbe, Zeev Zalevsky, Andreas
Herrman, and Shachar Richter. Rapid Particle Patterning in Surface
Deposited Micro-Droplets of Low Ionic Content via Low-Voltage
Electrochemistry and Electrokinetics. Scientific Reports 5 (2015).
2. Hendler, Netta, Elad Mentovich, Bálint Korbuly, Tamás Pusztai, László
Gránásy, and Shachar Richter. Growth Control of Peptide-Nanotube
Spherulitic Films: Experiments and Simulations. Nano Research 8,
no. 11 (2015): 3630–38.
3. Gordiichuk, Pavlo I, Dolev Rimmerman, Avishek Paul, Daniel A
Gautier, Agnieszka Gruszka, Manfred Saller, Jan Willem de Vries, et
al. ,Filling the Green Gap of a Megadalton Photosystem I Complex
by Conjugation of Organic Dyes. Bioconjugate Chemistry (2015).
4. Carmeli, Itai, Moshik Cohen, Omri Heifler, Yigal Lilach, Zeev Zalevsky,
Vladimiro Mujica, and Shachar Richter. Spatial Modulation of
Light Transmission through a Single Microcavity by Coupling of
Photosynthetic Complex Excitations to Surface Plasmons.Nature
Communications (2015).
5. Beilis, Edith, Bogdan Belgorodsky, Ludmila Fadeev, Hagai Cohen,
and Shachar Richter. Surface-Induced Conformational Changes in
Doped Bovine Serum Albumin Self-Assembled Monolayers. Journal
of the American Chemical Society 136, no. 17 (2014): 6151–54.
RESEARCHERS
Prof. Michael Gozin
Web: https://en-exact-sciences.tau.ac.il/profile/cogozin
Research Title
Chemistry of nitrogen-rich heterocycles and development of new
energetic materials
My group focuses on the development of novel
energetic compounds and nanomaterials for
various applications, including fire-extigushing
gas generators and materials for deep-well oil
and gas extraction. We work on synthesis and
comprehensive characterization of various nitrogenrich heterocycles, related metal complexes, energetic
nanomaterials based on graphene oxide derivatives
and energetic three-dimensional metal organic
frameworks. Selected Publications:
1. Yan, Qi-Long; Trzcinski, Waldemar A.; Cudzilo, Stanislaw; Paszula,
Jozef; Eugen, Trana; Liviu, Matache; Traian, Rotariu; Gozin, Michael.
Thermobaric effects formed by aluminum foils enveloping cylindrical
charges. Combustion and Flame (2016), 166, 148-157.
2. Yan, Qi-Long; Gozin, Michael; Zhao, Feng-Qi; Cohen, Adva; Pang,
Si-Ping. Highly energetic compositions based on functionalized
carbon nanomaterials”, Nanoscale (2016), 8(9), 4799-4851.
3. Cohen, Adva; Yan, Qi-Long; Shlomovich, Avital; Aizikovich, Alexander;
Petrutik, Natan; Gozin, Michael. Novel nitrogen-rich energetic
macromolecules based on 3,6-dihydrazinyl-1,2,4,5-tetrazine. RSC
Advances (2015), 5(129), 106971-106980.
4. Zeman, Svatopluk; Yan, Qi-Long; Gozin, Michael; Zhao, Feng-Qi;
Akstein, Zbynek. Thermal behavior of 1,3,5-trinitroso-1,3,5-triazinane
and its melt-castable mixtures with cyclic nitramines. Thermochimica
Acta (2015), 615, 51-60.
5. Aizikovich, A.; Shlomovich, A.; Cohen, A.; Gozin, M.. The nitration
pattern of energetic 3,6-diamino-1,2,4,5-tetrazine derivatives
containing azole functional groups. Dalton Transactions (2015),
44(31), 13939-13946.
6. Ramishetti, Srinivas; Kedmi, Ranit; Goldsmith, Meir; Leonard, Fransisca;
Sprague, Andrew G.; Godin, Biana; Gozin, Michael; Cullis, Pieter R.;
Dykxhoorn, Derek M.; Peer, Dan. Systemic gene silencing in primary
T lymphocytes using targeted lipid nanoparticlesACS Nano (2015),
9(7), 6706-6716.
RESEARCHERS
Prof. Chanoch Carmeli
Tel: 972-3- 6409826
Web: http://en-lifesci.tau.ac.il/profile/chanochc
Research Title
Nanotechnology of photosynthesis
1. Carmeli, I; Kumar, KS; Heifler, O; Carmeli, C., Naaman, R. Spin Selectivity
in Electron Transfer in Photosystem I. Agnew. Chem. Inter. Ed. 2014,
53, (34) 8953-8958.
2. H. Toporik, I. Carmeli, I. Volotsenko, M.Molotskii, Y. Rosenwaks, C.
Carmeli and N. Nelson, Large Photovoltages Generated by Plant
Photosystem I Crystals. Adv. Mater. 2012, 24, 2988–2991.
3. L. Sepunaru, I. Tsimberov, L. Forolov, C. Carmeli, I. Carmeli* and
Y.Rosenwaks*, Picosecond Electron Transfer From Photosysnthetic
Reaction Center Protein to GaAs Nano Lett. 2009, 9 (7) 2751-2755.
4. L. Frolov, Y. Rosenwaks, S. Richter, C. Carmeli and I. Carmeli,
Photoelectric Junctions Between GaAs and Photosynthetic Reaction
Center Protein, , J. Phys. Chem. C. 2008, 112, 13426-13430.
5. L. Frolov, O. Wilner, C. Carmeli and I. Carmeli, Fabrication of Oriented
Multilayers of Photosystem I Proteins on Solid Surfaces by AutoMetallization, Adv. Mater. 2008, 20, 263–266.
The reaction center photosystem I (PSI) is a
membrane protein-chlorophyll complex. PSI
functions as a photodiode converting light
quanta into electrical charges of 1V at a quantum
efficiency of ~100%. We investigate the novel
properties of hybrid PSI-metals - metal nanoparticles,
semiconductors and nanotube devices, and study
the interaction between PSI and the solids, and the
efficiency of charge transfer through the fabricated
electronic junctions.
Oriented monolayers and multilayers of PSI are
self-assembled by forming a sulfide bond between
metal surfaces and unique cysteine mutants of
genetically modified PSI from cyanobacteria. The dry
layers generate photo potential. Covalent junctions
between the protein and the solid surface form
efficient electronic junctions that mediate charge
transfer at a ps time scale. Oriented multilayers
are fabricated by autometalization, with cross
linker molecules connecting the serial layers.
When placed between metal and transparent
electrodes, photovoltage and a photocurrent are
generated. The oriented multilayers of PSI enhance
the photovoltage and photocurrent, due to the
serial arrangement of the dipoles and the enhanced
absorption cross section. A surface photo potential
of up to 100V was recorded in PSI crystals where
hundreds of layers were serially oriented.
Hybrids of carbon nanotubes and PSI are fabricated
by activating the nanotubes and attaching the
unique cysteine in the engineered protein through
small bifunctional molecules. PSI that has cysteine
on both the oxidizing and reducing ends of the
protein forms junctions - either between nanotubes
or between nanotubes and metal electrodes. The
PSI in hybrid PSI-nanotube devices thus enhances
the nonotubes’ photo conductance by an order of
magnitude.
RESEARCHERS
Prof. Yossi Rosenwaks
Web: http://www.eng.tau.ac.il/~yossir
Research Title
Nanoscale electrical devices
Prof. Rosenwaks leads a research group of 10
graduate students and scientists, and his current
research interests include: nanoscale electrical
measurements using mainly Kelvin probe force
microscopy, nanowire transistors and sensors, charge
carrier dynamics and transport in semiconductors,
and Kelvin probe microscopy of 2D materials.
1. Alex Henning, Nandhini Swaminathan, Andrey Godkin, Gil Shalev,
Iddo Amit, and Yossi Rosenwaks, Tunable diameter electrostaticallyformed nanowire for high sensitivity gas sensing, Nano Research,
DOI 10.1007/s 12274-01, (2015).
2. A. Henning, M. Molotskii, N. Swaminathan, Y. Vaknin, A. Godkin,
G. Shalev, and Y. Rosenwaks, Electrostatic Limit of Detection of
Nanowire-based Sensors, Small, DOI: 10.1002/smll.201500566, (2015).
3. G. Segev, I. Amit, A. Godkin, A. Henning, and Y. Rosenwaks, Multiple
State Electrostatically Formed Nanowire Transistors, IEEE Electron
Device Lett. DOI: 10.1109/LED.2015.2434793, (2015).
4. I. Amit, N. Jeon, L. J. Lauhon, and Y. Rosenwaks, The Impact of Dopant
Compensation on Graded p-n Junctions in Si Nanowires, ACS
Applied Materials & Interfaces, 8 (1), pp 128–134, (2016).
5. Nandhini Swaminathan, Alex Henning, Yonathan Vaknin, Klimentiy
Shimanovich, Andrey Godkin,Gil Shalev, and Yossi Rosenwaks,
Dynamic Range Enhancement Using the Electrostatically Formed
Nanowire Sensor, ACS Sensors, DOI: 10.1021/acssensors.6b00096.
RESEARCHERS
Dr. Tal Dvir
Web: dvirlab.tau.ac.il
Research Title
Tissue engineering and regenerative medicine
1. Feiner R, Engel L, Fleischer S, Malki M, Gal I, Shapira A, ShachamDiamand Y, Dvir T. Engineered hybrid cardiac patches with
multifunctional electronics for online monitoring and regulation
of tissue function. Nature Materials. 2016 Mar 14. doi: 10.1038/
nmat4590.
2. Baranes K, Shevach M, Shefi O, Dvir T. Gold Nanoparticle-Decorated
Scaffolds Promote Neuronal Differentiation and Maturation. Nano
Letters 2015 Dec 19.
3. Fleischer S, Miller J, Hurowitz H, Shapira A, Dvir T. Effect of fiber
diameter on the assembly of functional 3D cardiac patches.
Nanotechnology. 2015 Jul 24;26(29):291002.
Our lab develops smart bio- and nanotechnologies
for engineering complex tissues. Our work focuses
on engineering cardiac patches for treating patients
after heart attacks, and on developing cyborg tissues
that integrate micro- and nanoelectronics with living
organs to control their performance.
RESEARCHERS
Dr. Alexander Golberg
Affiliation: Environmental Studies
Web: http://www.tau.ac.il/~agolberg/
Research Title
Bioengineering for sustainability and health
1. Towards marine biorefineries: Selective proteins extractions from
marine macroalgae Ulva with pulsed electric fields. Polikovsky, M,
Fernand, F, Sack, M, Frey,W, Müller G, Golberg, A. Innovative Food
Science & Emerging Technologies. 2016.
2. Global potential of offshore and shallow waters macroalgal
biorefineries to provide for food, chemicals and energy: feasibility
and sustainability, Lehahn Y, Ingle, K.N, Golberg A. Algal Research.
2016.
3. Long-term Listeria monocytogenes proliferation control in milk
by intermittently delivered pulsed electric fields, implications for
food security in the low-income countries. Golberg, A. Technology.
3(1):1-6, 2015.
4. Cloud-enabled microscopy and droplet microfluidic platform for
specific detection of Escherichia coli in water. Golberg, A, Linshiz,
G, Kravets, I, Stawski, N, Hillson, N, Yarmush ML,Marks, RS, Konry, T.
Equal contributions. PLoS ONE 9(1): e86341.20.
5. Nanolayered siRNA Delivery Platforms for Local Silencing of
CTGF Reduce Cutaneous Scar Contraction in Third-Degree Burns,
Castleberry, SA, Golberg, A, Abu Sharkh,M, Khan,S, Almquist, BD,
Austen WG Jr., Yarmush,ML, Hammond, PT. Biomaterials. 2016. 14;95:2.
Global population growth and a rising quality of life in the era of climate
change are expected to increase the demand for food, chemicals and
fuels. A possible, sustainable direction for addressing this challenge is
the production of biomass and the conversion of this biomass into the
required products through a complex system known as a biorefinery.
However, concerns over net energy balance, potable water use and
environmental hazards, and uncertainty with regard to processing
technologies — mostly problems with lignin—
raise questions regarding the actual potential of
terrestrial biomass to meet the anticipated food,
feed and energy challenges in a sustainable way.
An alternative source of biomass for biorefineries
is offshore-grown macroalgae. Macroalgae have
been harvested throughout the world for centuries,
both as a food source and as a commodity for the
production of hydrocolloids. However, to date,
macroalgae still represent only a tiny percentage
of the global biomass supply: ~17∙10E6 tons fresh
weight (FW) of macroalgae compared to 16∙10E11
tons of terrestrial crops, grasses and forests. A
presently expanding body of evidence suggests
that offshore-cultivated macroalgae, which contain
very little lignin, and do not compete with food
crops for arable land or potable water, can provide
an alternative source of biomass for the sustainable
production of food, chemicals and fuels.
The goal of our laboratory is to develop a fundamental
understanding of energy flows in offshore marine
biorefineries, to boost the net energy return on
investment, and to develop new technologies at
the nano, micro and macro levels for implementing
marine biorefineries for the benefit of humanity and
society. To this end we are currently developing:
1) a climate simulator in silica and experimentally;
2) technologies for algae breeding “from spore to
sea”, microdevices for studying seaweed-bacteria
interactions; 3) a portfolio of computational and
experimental tools for biomass deconstruction
and fermentation.
RESEARCHERS
Prof. Judith Rishpon
Web: http://www.tau.ac.il/lifesci/departments/biotech/members/rishpon/rishpon.html
Research Title
Bioelectrochemistry and biosensors
1. Bareket, L., Rephaeli, A., Berkovitch, G., Nudelman, A. & Rishpon .J.
Carbon nanotubes based electrochemical biosensor for detection
of formaldehyde released from a cancer cell line treated with
formaldehyde-releasing anticancer prodrugs. Bioelec (2011).
2. Adler-Abramovich, L., Badihi-Mossberg, M., Gazit, E. & Rishpon,
J. (2010). Characterization of Peptide-Nanostructure-Modified
Electrodes and Their Application for Ultrasensitive Environmental
Monitoring Small 6, 825-831.
3. Vernick, S.; Freeman, A.; Rishpon, J.; et al.(2011). Electro-hemical
Biosensing for Direct Biopsy Slices Screening for Colorectal Cancer
Detection. JOURNAL OF THE ELECTRO-CHEMICAL SOCIETY 1581
P1-P4.
4. Rishpon, Judith; Popovtzer, Rachela; Shacham-Diamand, Yosi; et al.
(2012). Electrochemical methods of detecting colon cancer cells
and use of same for diagnosing and monitoring treatment of the
diseasePatent Number: US 08268577. Patent Assignee: Ramot
5. Rishpon, J.; Popovtzer, R.; Shacham-Diamand, Y.; et al. (2013)
Electrochemical methods of detecting cancer with 4-aminophenyl
phosphate. Patent Number: US 08530179.
Our research is centered on the fundamentals of
biological interactions at solid-liquid interfaces,
with emphasis on electrochemical biosensors.
Sensors for medical diagnostics, environmental
pollution, food safety and veterinary uses were
developed. Modification of nanoparticles, such
as carbon nanotubes, gold nanotubes or peptide
nanoparticles significantly increases the sensitivity
of the sensors, enabling measurement of extremely
low concentrations.
RESEARCHERS
Prof. Noam Eliaz
Web: http://www.eng.tau.ac.il/~neliaz/
Research Title
From corrosion in space to degradation in vivo and functionality
of implants
The Biomaterials & Corrosion Laboratory at Tel
Aviv University strives to meet the demands of
modern society by developing and studying
advanced materials for a variety of applications - in
biomedicine, space, harsh environments and other
areas. Following are some of the lab’s internationally
renowned achievements:
1) The development of a novel electrochemicallydeposited hydroxyapatite and other calcium
phosphate coatings for orthopedic and dental
implants. Our current generation of coatings is
on its way to commercial use via collaboration
with a manufacturer of dental implants, and we
are now working on future generations. These will
incorporate biological matter and drugs to reduce
infections, increase osseointegration, and improve
mechanical properties. In addition, self-assembled
monolayers applied to the titanium substrate will
enhance the strength of adhesion.
2) Electroplating and electroless plating of
rhenium-based alloys. These projects, conducted
in collaboration with Prof. Eliezer Gileadi from the
TAU School of Chemistry, and funded by the US
AFOSR and Israel’s DoD, are intended mainly for
aerospace, aircraft, and catalysis applications. Prof.
Eliaz has studied the structure of such deposits at the
atomic scale, using atom probe tomography (APT)
and aberration-corrected transmission electron
microscopy.
3) The magnetic isolation of biological matter for
purposes of diagnosing diseases (such as cancer
and osteoarthritis), determining the efficacy of drug
treatment, and monitoring the wear of artificial
joints - either at the design stage or during service
in vivo. Ours is the only lab outside the US to have
this capability, which is based on Bio-Ferrography.
1. N. Metoki, L. Liu, E. Beilis, N. Eliaz and D. Mandler. (2014) Preparation
and characterization of alkylphosphonic acid self-assembled
monolayers on titanium alloy by chemisorption and electrochemical
deposition. Langmuir, 30(23), 6791-6799.
2. H. Zanin, C. Rosa, N. Eliaz, P. May, F. Marciano and A. Lobo. (2015)
Assisted deposition of nano-hydroxyapatite onto exfoliated carbon
nanotube oxide scaffolds. Nanoscale, 7, 10218-10232.
3. O. Levi, A. Shapira, B. Tal, I. Benhar and N. Eliaz. (2015) Isolating
epideral growth factor receptor overexpressing carcinoma cells
from human whole blood by Bio-Ferrography. Cytometry: Part
B – Clinical Cytometry, 88, 136-144.
4. O. Levi, B. Tal, S. Hileli, A. Shapira, I. Benhar, P. Grabov and N. Eliaz.
(2015) Optimization of EGFR high positive cell isolation procedure
by Design of Experiments methodology. Cytometry: Part B – Clinical
Cytometry, 88, 338-347.
5. T. Nusbaum, B.A. Rosen, E. Gileadi and N. Eliaz. (2015) Effect of pulse
on-time and peak current density on pulse plated Re-Ni alloys. J.
Electrochem. Soc., 162(7), D250-D255.
RESEARCHERS
Dr. Oswaldo Dieguez
Web: http://www.eng.tau.ac.il/~dieguez/
Research Title
Atomistic simulation of materials
At the Atomistic Simulation of Materials group we
research materials by computationally solving the
equations that their atoms follow. In this way we
understand the properties of materials, perform
virtual experiments under conditions that are hard
to achieve in a real lab, and design new materials
with tailored properties.
We focus on ferroelectrics - materials with
technological applications in computer memories,
sensors and actuators. We aim to advance the design
of ferroelectrics by understanding their properties
and improving them. Current topics of interest at our
lab are ferroelectric domain walls and ferroelectrics
that show magnetic ordering (multiferroics).
We also study other materials in collaboration with
experimentalists. Over the last two years we carried
out simulations in order to understand experiments
in the growth of transition metal silicide nanoislands, learn about the structure of ReNi metallic
alloys, and characterize the adsorption of polymers
on metals in photovoltaic cells - to name several
examples.
1. Epitaxial phases of BiMnO3 from first principles; O. Diéguez and J.
Íñiguez: PHYSICAL REVIEW B 91, 184113 (2015).
2. Domain walls in a perovskite oxide with two primary structural
order parameters: first-principles study of BiFeO3; O. Diéguez, P.
Aguado-Puente, J. Junquera, and J. Iniguez: PHYSICAL REVIEW B
87, 024102 (2013).
3. First-Principles Investigation of Morphotropic Transitions and PhaseChange Functional Responses in BiFeO3-BiCoO3 Multiferroic
SolidSolutions; O. Diéguez, and J. Iniguez: PHYSICAL REVIEW LETTERS
107, 057601 (2011).
4. First-principles predictions of low-energy phases of multiferroic
BiFeO3; O. Diéguez, O.E. Gonzalez-Vazquez, J. Wojdel, and J. Iniguez:
PHYSICAL REVIEW B 83, 094105 (2011).
5. The SIESTA method; developments and applicability; E. Artacho, E.
Anglada, O. Diéguez, J.D. Gale, A. Garcia, J. Junquera, R.M. Martin,
P. Ordejon, M.A. Pruneda, D. Sanchez-Portal, and J. Soler: JOURNAL
OF PHYSICS-CONDENSED MATTER 20, 064208 (2008).
RESEARCHERS
Prof. Oded Hod
Web: http://www.tau.ac.il/~odedhod/
Research Title
Computational nanomaterials science
Nanoscience and nanotechnology open a unique
opportunity for applying highly accurate theories
to realistic material science problems. Research in
my group focuses on the theoretical study of the
mechanical, electronic, magnetic and transport
properties of systems at the nanoscale. Using
first-principles computational methods, we aim to
characterize both the ground state and dynamical
properties of such systems.
A combination of codes developed within our group,
along with commercial computational chemistry
packages, operating on a highly parallelizable
high-performance computer cluster, allows us to
address the properties and functionality of a variety
of systems, ranging from carefully tailored molecular
structures all the way to bulk systems.
In addition to questions of basic science, we
pursue the design of technologically applicable
nanoscale material properties, for future applications
in fields such as nano-electronics, nano-spintronics,
accurate and sensitive chemical sensing and nanomechanical devices.
1. R. Pawlak, W. Ouyang, A. E. Filippov, L. Kalikhman-Razvozov, S. Kawai,
T. Glatzel, E. Gnecco, A. Baratoff, Q. Zheng, O. Hod, M. Urbakh, and E.
Meyer, Single Molecule Tribology: Force Microscopy Manipulation
of a Porphyrin Derivative on a Copper Surface, ACS Nano 10, 713722 (2016).
2. J. E. Peralta, O. Hod, and G. E. Scuseria, Magnetization Dynamics
From Time-Dependent Non-Collinear Spin Density Functional
Theory Calculations, J. Chem. Theory Comput. 11, 3661-3668 (2015).
3. T. Zelovich, L. Kronik, and O. Hod, Molecule-Lead Coupling at
Molecular Junctions: Relation Between the Real- and State-Space
Perspectives, J. Chem. Theory Comput. 11, 4861-4869 (2015).
4. D. Krepel, J. E. Peralta, G. E. Scuseria, and O. Hod, Graphene
Nanoribbons-Based Ultrasensitive Chemical Detectors, J. Phys.
Chem. C 120, 3791-3797 (2016).
5. I. Oz, I. Leven, Y. Itkin, A. Buchwalter, K. Akulov, and O. Hod, Nanotubes
Motion on Layered Materials: A Registry Perspective, J. Phys. Chem.
C 120, 4466-4470 (2016).
RESEARCHERS
Dr. Amir Natan
Web: http://www.eng.tau.ac.il/~amirn/
Research Title
Multiscale simulations of materials and processes
The goal of our lab is to develop and use multiscale
models for materials, interfaces and processes for
energy applications. We also aim to bridge between
atomistic quantum and classical models and largerscale continuum equations that will eventually allow
us to simulate a whole device. We develop formalism
and code within the real-space PARSEC Density
Functional Theory (DFT) and the time dependent
DFT (TDDFT) package, and aim to achieve very fast
calculations of FOCK exchange and post HartreeFock methods for large systems. Combining DFT
and classical Molecular Dynamics (MD) we model
materials and processes for future batteries and
photovoltaic applications. We also use machine
learning strategies and DFT to improve future MD
simulations for such materials. Data mining strategies
are used to search for and select new metal oxide
materials, and to associate their structure with some
desired properties.
1. Natalia Kuritz, Michael Murat, Moran Balaish, Yair Ein-Eli, and Amir
Natan, PFC and Triglyme for Li-Air Batteries: A Molecular Dynamics
Study – Journal of Physical Chemistry B (2016) DOI: 10.1021/acs.
jpcb.5b12075.
2. Nicholas Boffi, Manish Jain and Amir Natan, Asymptotic behavior
and interpretation of virtual states: the effects of confinement and
of basis sets – J. Chem. Phys. 144, 084104 (2016).
3. M. Zuzovski, A. Boag and A. Natan, Auxilliary grid method for the
calculation of electrostatic terms in Density Functional Theory on
a real-space grid, PCCP, 17, 31510, (2015).
4. Yevgeny Rakita, Diana Golodnitsky, Amir Natan, Electrostatic
potential of polyelectrolyte molecules grafted on charged surfaces:
A Poisson-Boltzmann model, Journal of Electrochemical Society
161 (8), E3049-E3058, (2014).
5. Amir Natan, Ayelet Benjamini, Doron Naveh, Leeor Kronik, Murilo
L. Tiago, Scott P. Beckman,and James R. Chelikowsky, Real Space
Pseudopotential method for first principles calculations of general
periodic and partially periodic systems, Phys. Rev. B 78, 075109 (2008).
RESEARCHERS
Prof. Michael Urbakh
Web: www.tau.ac.il/~urbakh1/
Research Title
Theory and simulations of friction at the nanoscale
1. Urbakh M., Klafter J., Gourdon D., Israelachvili J., The nonlinear nature
of friction, Nature 430, 525-528 (2004).
2. Dudko O., Filippov A.E., Klafter J., Urbakh M., Beyond the conventional
description of dynamic force spectroscopy of adhesion bonds,
Proc. National Academy of Sciences USA, 100, 11378–11381 (2003).
3. Ma M, Grey F., Shen L., Urbakh M., Wu S., Liu Z. J., Liu Y and Zheng
Q. Water transport inside carbon nanotubes mediated by phononinduced oscillating friction, Nature Nanotech., 10, 692-696 (2015).
4. Ma M., Benassi A., Vanossi A., and Urbakh M., Critical Length Limiting
Superlow Friction, Phys. Rev. Lett. 114, Art. 055501 (2015).
5. W. Ouyang, M. Ma, Q. Zheng, and M. Urbakh, Frictional Properties
of Nanojunctions Including Atomically Thin Sheets. Nano Letters,
16, 1878−1883 (2016).
Since 1995, Michael Urbakh has been working on the theory of friction
at the nano and mesoscales. Frictional motion plays a central role in
diverse systems and phenomena that span a vast range of scales, from
the nanometer contacts inherent in micro- and nano-machines and
biological molecular motors, to the geophysical scales of earthquakes.
The focus of research in the Michael Urbakh group is on a molecular
level description of processes occurring between interacting surfaces in
relative motion, which is needed to first understand, and later manipulate,
friction. Important new results obtained by Michael Urbakh in this
field include:
• Understanding the mechanism of transition from stick-slip motion
to sliding
• Predicting and characterizing new regimes of frictional motion, in
particular chaotic stick-slip and inverted stick-slip motion
• Understanding the origin of a finite lifetime of superlubricity between
incommensurate surfaces, and suggesting novel ways to stabilize
the low-friction superlubric state
• Describing friction in terms of rupture and formation of surface
junctions
• Describong thermal effects on nanoscale friction,
and understanding the origin of unexpected
nonmonotonic dependence of nanoscale friction
on temperature
• Understanding the mechanism of wear and ripple
formation in nanoscale friction
• Understanding the mechanism of onset of sliding
motion for elastic sliders with extended rough
interfaces
• Bridging a gap between descriptions of friction
at the nano and macroscales
• Developing novel methods for controlling friction
using mechanics and chemistry
A distinctive feature of research in the Michael
Urbakh group is the development of minimal
models which focus on a small number of the
most relevant degrees of freedom of dynamical
systems, but can nevertheless explain phenomena
of high complexity. Moreover, the proposed minimal
models have enabled predictions that were later
verified experimentally. A special highlight was
the remarkable prediction of the possibility of
controlling friction mechanically via vibrations
of small amplitude and energy. Michael Urbakh
demonstrated that manipulation by mechanical
excitations, when applied at the right frequency,
amplitude and direction, pulls the molecules out of
their potential energy minima and thereby reduces
friction (at other frequencies or amplitudes the
friction can be increased). This work stimulated
experimental studies that confirmed the theoretical
prediction, and recently this idea has been used by
IBM in the development of the ultrahigh-density
data storage device Millipede.
The theoretical approaches developed in the field
of nanoscale friction led to breakthroughs in other
fields, such as single molecule force spectrosopcy
and molecular motors. In particular, Michael
RESEARCHERS
Urbakh developed a novel method for revealing molecular scale
energy landscapes from the results of force unfolding experiments,
which is now widely used in many experimental laboratories. Another
development was a new approach to building microscopic engines on
the nano and microscales, allowing efficient transformation of the fed
energy into directed motion. These engines can move translationally or
rotationally on surfaces, and perform useful functions such as pulling
a nanoscale cargo.
RESEARCHERS
Prof. Haim Diamant
Web: tau.ac.il/~hdiamant
Research Title
Theory of complex fluids
Our research group attempts to understand the
structure and dynamic response of soft materials
and complex fluids using analytical models. Recent
projects have included: instabilities in thin sheets,
dynamics of driven colloidal suspensions, and
correlations in confined fluids.
1. Diamant, H. (2015). Response of a polymer network to the motion
of a rigid sphere. Eur. Phys. J. 38, 32.
2. Oshri, O., Brau, F., Diamant, H. (2015). Wrinkles and folds in a fluidsupported sheet of finite size. Phys. Rev. E 91, 052408.
3. Sonn-Segev, A., Blawzdziewicz, J., Wajnryb, E., Ekiel-Jezewska, M.
L., Diamant, H., Roichman, Y. (2015). Structure and dynamics of a
layer of sedimented Brownian particles. J. Chem. Phys. 143, 074704.
4. Oshri, O., Diamant, H. (2016). Properties of compressible elastica
from relativistic analogy. Soft Matter 12, 664-668.
5. Goldfriend, T, Diamant, H., Witten, T. A. (2015). Hydrodynamic
interactions between two forced objects of arbitrary shape: I Effect
on alignment. Phys. Fluids 27, 123303.
RESEARCHERS
Prof. Diana Golodnitsky
Web: http://www2.tau.ac.il/nano/researcher.asp?id=dbjhegflh
Research Title
Nanomaterials and thin films for electrochemical energy storage
and conversion
1. Moran Balaish, Emanuel Peled, Diana Golodnitsky and Yair Ein-Eli,
Liquid-Free Lithium-Oxygen Batteries, Angewandte Communications,
54, 2 ,436–440 (2015)
2. E. Zygadło-Monikowska, Z. Florjańczyk, J. Ostrowska, E. Peled and D.
Golodnitsky Synthesis and characterization of lithium-salt complexes
with difluoroalkoxyborates for application as lithium electrolytes.
Electrochimica Acta, 175, 104-112 (2015)
3. K. Goldshtein, K. Freedman, D. Schneier, L. Burstein, V. Ezersky, E.
Peled and D. Golodnitsky Advanced Multiphase Silicon-Based
Anodes for High-Energy-Density Li-Ion Batteries, Journal of The
Electrochemical Society, 162 (6) A1072-A1079 (2015)
4. E. Peled, F. Patolsky, D. Golodnitsky, K.Freedman, G. Davidi, D.
Schneier Tissue-like Silicon Nanowires-Based Three-Dimensional
Anodes for High-Capacity Lithium Ion Batteries, DOI: 10.1021/acs.
nanolett.5b0074, Nano Lett., 2015
5. R. Blanga, L. Burstein, M. Berman, S. G. Greenbaum, and D.
Golodnitsky Solid Polymer-in-Ceramic Electrolyte Formed by
Electrophoretic Deposition Journal of The Electrochemical Society,
162 (11) D3084-D3089,(2015) FOCUS ISSUE ON ELECTROPHORETIC
DEPOSITION
6. D. . Golodnitsky, E. Strauss, E. Peled, S. Greenbaum, Review—On Order
and Disorder in Polymer Electrolytes Journal of The Electrochemical
Society, 162 (14) A1-A16 (2015) invited paper.
7. D. Golodnitsky , E. Strauss, T. Ripenbein, PSi-Based Supercapacitors
in the book “Porous Silicon: From Formation to Application”, v.3
Chapter 16, (2016), 345-372.
My major research activities focus on the synthesis and characterization of
materials and the study of ion-transport phenomena in new nanostructured
electrodes and solid electrolytes for energy-storage devices.
The microelectronics industry is continually reducing the size of its
products in order to produce small devices such as medical implants,
microsensors, self-powered integrated circuits or
microelectromechanical systems. Such devices
need rechargeable microbatteries with dimensions
on the scale of 1–10mm3, high energy density and
high power capability.
A 3D concentric microbattery on a Si chip or
on 3D-printed polymer substrates enables the
fabrication of a network of 10,000-30,000 units
connected in parallel, minimizing the ion-path
length between the electrodes, and providing
high capacity per footprint area. This is achieved
by the insertion of four consecutive thin-film battery
layers into the high-aspect-ratio microchannels of
the perforated chip or polymer. For the first time,
the electrophoretic deposition (EPD) method is
exploited for the preparation of thin-film active
battery materials. Different solvents and surfaceactive agents are tested, with the aim of achieving
well-dispersed nanoparticles in stable suspensions.
Such systems are controlled by the complex
interplay of concomitant phenomena, including
micellization, association of the surfactant with
the polymer and adsorption of the surfactant on
the species. Of particular interest is the effect of
these cooperative interactions on the structure and
ion-transport properties of polymer electrolytes
confined in the pores of ceramics. 3D-tomography
tests (carried out in collaboration with Imperial
College, London) provide the data sets for the
calculation of the tortuosity factor at sub-100nm
resolution. To produce core-shell and multiphase
ceramic/alkali-metal salt nanoparticles, the method
of mechanochemistry is used.
Very recent subjects under investigation include
redox processes in a high-energy-density allsolid-state lithiated Si/S battery (together with
Prof. Emanuel Peled), and adsorption phenomena
in supercapacitors based on porous silicon
nanostructures.
RESEARCHERS
Prof. Gil Markovich
Web: http://chemistry.tau.ac.il/markovich/
Research Title
Colloidal nanomaterials
The Markovich group is working on several types
of nano-systems:
1. Nanoscale chirality. Here we study the interaction
of chiral biomolecules with inorganic nanostructures
such as metal and semiconductor nanocrystals.
These interactions may lead to induction of optical
activity in plasmon and exciton resonances in the
inorganic nanoparticles, and we are interested in
understanding the mechanism of such interactions.
We have also demonstrated that nanostructures of
materials like mercury sulfide, tellurium and selenium,
which have crystal structures that are intrinsically
chiral, can be synthesized enantioselectively
using chiral biomolecules such as cysteine and its
derivatives as surface stabilizers.
2. Magnetic nanoparticles. We have performed
several studies involving magnetic nanocrystals.
In particular, we worked with magnetite (Fe3O4)
nanocrystals and studied the magnetization
dynamics of individual magnetite nanocrystals
using a variable temperature STM. Using the same
technique, we also studied the Verwey metalinsulator phase transition in individual magnetite
nanocrystals at ~100K.
Another project involving magnetic nanoparticles
is the development of printable magnetic sensors
based on nickel nanoparticle ink, together with Prof.
Alexander Gerber’s group at TAU’s School of Physics.
3. Metal nanowire films as transparent electrodes.
We are developing a simple wet chemical process
for the preparation of thin gold/silver nanowire
films, to be applied as transparent electrodes for
various applications.
1. Amir Hevroni, Boris Tsukerman, Gil Markovich, Probing magnetization
dynamics in individual magnetite nanocrystals using magnetoresistive
scanning tunneling microscopy, Phys. Rev. B 92, 224423 (2015).
2. Assaf Ben-Moshe, Sharon Grayer Wolf, Maya Bar Sadan, Lothar Houben,
Zhiyuan Fan, Alexander O. Govorov, Gil Markovich, Enantioselective
control of lattice and shape chirality in inorganic nanostructures
using chiral biomolecules, Nat. Comm. 5, 4302 (2014).
3. Ben M. Maoz, Yulia Chaikin, Alexander B. Tesler, Omri Bar Elli, Zhiyuan
Fan, Alexander O. Govorov, Gil Markovich, Amplification of Chiroptical
Activity of Chiral Biomolecules by Surface Plasmons, Nano Lett. 13,
1203-1209 (2013).
4. Daniel Azulai, Elad Cohen, Gil Markovich, Seed concentration control
of metal nanowire diameter, Nano Lett. 12, 5552-5558 (2012).
5. Assaf Ben Moshe, Daniel Szwarcman, Gil Markovich, The size
dependence of chiroptical activity in colloidal quantum dots, ACS
Nano 5, 9034–9043 (2011).
RESEARCHERS
Prof. Ori Cheshnovsky
Web: http://www3.tau.ac.il/cheshnovsky/index.php
Research Title
Single nano-object spectroscopic microscopy
1. O. Tzang, A. Pevzner, R.E. Marvel, R.F. Haglund, O. Cheshnovsky(2015).
Super-Resolution in Label-Free Photomodulated Reflectivity, Nano
Letters, 15, 1362.
2. O. Tzang, O. Cheshnovsky (2015). New modes in label-free super
resolution based on photo-modulated reflectivity, Optics Express,
23, 20926.
3. T. Juffmann, A. Milic, M. Mullneritsch, P. Asenbaum, A. Tsukernik, J.
Tuxen, M. Mayor, O. Cheshnovsky. M. Arndt. (2012). Real time single
molecule imaging of quantum interference.. Nature Nanotechnology,
7 296-299.
4. Z. Ioffe,, T. Shamai, A. Ophir, G. Noy, I. Yutsis, K. Kfir, O. Cheshnovsky,
Y. Selzer.(2008). Detection of heating in current carrying molecular
junctions by Raman scattering,Nature Nanotechnology 3, 727.
5. E. Flaxer, O. Sneh and O. Cheshnovsky. (1993) Molecular light emission
induced by inelastic electron tunneling. Science 262, 2012-2014.
Single nano-object spectroscopic microscopy
Single-molecule spectroscopic detection in fluorescent microscopy is
already well established. However, not all molecules of interest fluoresce.
In our laboratory we are developing a new approach to measuring the
light absorption of single nano-objects, including single molecules. We
use a supercontinuum laser (Fianium) and an Acousto Optical Tunable
Filter to select the wavelength. The absorption detection is then carried
out by an auto-balanced photodiode-pair aimed to suppress the laser
noise, and a lock-in detection of a special absorption modulation
technique. This is critical for enabling the detection of light absorbed by
a single particle in the order of 10-4-10-7, which is orders of magnitude
smaller than the intensity fluctuations of the light source.
One of our long-term scientific goals is to characterize the spectroscopic
properties of specially designed Si/Ge core shell nanowires (fabricated
by our collaborators in the Patolsky lab), which according to theoretical
predictions by A. Zunger are characterized by a direct band gap. In
other projects we monitor the interaction between localized plasmons
and excitons in WS2 nanorods.
Label-free super-resolution microscopy
Far-field super-resolution (SR) microscopy has
become an important tool in life sciences. However,
it relies on, and therefore is limited by, the ability to
control the fluorescence of label molecules.
We introduce a new far-field label-free SR
methodology that is based on the nonlinear
response of the reflectance to photo-modulation.
It relies on the ability to photo-excite nonlinearly
spatial distribution of temperature and charge
carriers inside the diffraction-limited spot, by an
ultra-short pump pulse. An overlapping delayed
probe pulse monitors reflectance changes. Spatial
resolution within the diffraction-limited spot is
enhanced due to nonlinearities in photo-modulated
properties of the matter. The method is suitable
for characterizing semiconductors and metals in
vacuum, ambient and liquid semi-transparent
and opaque systems, ultrathin and thick samples
alike. The fast response of the basic methodology
(picoseconds) will enable video rate scanning laser
nanoscopy.
We have demonstrated several examples of such
resolution enhancement due to nonlinearities:
The change of thermo-reflectance of VO2 upon
its characteristic insulator-to-metal transition at
~340K, the heating process of nanostructured silicon
or gold surfaces, and the nonlinear response of
photo-modulated Raman spectra. Resolution down
to 85nm is demonstrated. Based on similar ideas we
focus on improving current SR methods intended
for the biomedical research community.
RESEARCHERS
Prof. Emanuel Peled
Web: nano.tau.ac.il/peled
Research Title
Nanomaterials and thin films for electrochemical energy storage
and conversion
Our research focuses on the development and
characterization of novel and improved batteries.
We have developed a molten-sodium/air battery
operating at above the melting point of sodium
(97.8oC). This battery, in addition to eliminating
dendrite formation, can accelerate sluggish cathode
reactions and lower cell impedance. We explored
the key parameters that affect the performance of
the electrodes and their impact on the operation
of the molten-Na/air cell in glymes, PYR14TFSI ionic
liquid and polyethylene oxide-based electrolytes.
We have developed a very active oxygen reduction
reaction (ORR). By using a core-shell nanostructure
concept, we were able to reduce the amount of
platinum, while at the same time increasing the
activity of the ORR catalysts.
We have succeeded in the development of anodes
made of silicon nanowires and silicon nanoparticles
coated with protective layers. These anodes
demonstrate excellent performance that meets
the requirements of lithium batteries for portable
and electric-vehicle applications.
We investigate the impact of cathode design, type
of electrolyte and type of cathode binder on the
cathode reactions and on battery performance of
lithium-sulfur batteries. Additionally, we investigate hybrid double-layer
capacitors (HDLCs) that offer at least five times
more energy density than water-based doublelayer capacitors (DLC).
1. H. Mazor, D. Golodnitsky, L. Burstein, A. Gladkich, E. Peled,
Electrophoretic deposition of lithium iron phosphate cathode for
thin-film 3D-microbatteries, Journal of Power Sources 198, (2012)
264-272.
2. K. Goldshtein, D. Golodnitsky E. Peled, L. Adler-Abramovich, E. Gazit, S.
Khatun, P. Stallworth, S. Greenbaum. Effect of peptide nanotubeller on
structural and ion-transport properties of solid polymer electrolytes
Solid State Ionics 220 (2012) 39–46
3. E. Peled. Development and Characterization of Composite YSZ-PEI
Electrophoretically Deposited Membrane for Li-Ion Battery, J Phys.
Chem. B, 117 (2013) (6), 1577–1584
4. E. Peled, D. Golodnitsky, R. Hadar, H. Mazor, M. Goor and L Burstein,
Challenges and Obstacles in the Development of Sodium-Air
Batteries, Journal of Power Sources 244 (2013) 771-776
5. E. Peled, D. Golodnitsky, R. Hadar, H. Mazor, M. Goor and L Burstein,
Challenges and Obstacles in the Development of Sodium-Air
Batteries, Journal of Power Sources 244 (2013) 771-776
RESEARCHERS
Prof. Abraham Nitzan
Web: http://atto.tau.ac.il/~nitzan/nitzan.html
Research Title
Theoretical aspects of chemical dynamics
Research in my group focuses on theoretical aspects
of chemical dynamics. This branch of chemistry
describes the nature of physical and chemical
processes underlying the progress of chemical
reactions, with the aim of understanding such
processes and being able to predict their course
of evolution. In particular, our studies deal with
chemical processes involving interactions between
light and matter, chemical reactions in condensed
phases and at interfaces, and transport phenomena
in complex systems. Our main research emphases
are:
• Energy transfer processes in molecular systems
• Molecular dynamics in condensed phases
• Ionic transport in complex environments
• Optical properties and photochemistry of
adsorbed molecules
• Electron transport through molecular layers and
wires
• Classical and quantum thermodynamics of energy
conversion processes
1. A. Migliore and A. Nitzan, Irreversibility in redox molecular conduction:
single versus double metal-molecule interfaces Electrochimica
Acta 160, 363–375 (2015).
2. K. Kaasbjerg and A. Nitzan, Theory of light emission from quantum
noise in plasmonic contacts: above-threshold emission from higherorder electron-plasmon scattering, Phys. Rev. Letters, 114, 126803
(2015).
3. W. Dou, A. Nitzan and J. E. Subotnik, Surface hopping with a manifold
of electronic states. II. Application to the many-body AndersonHolstein model, J. Chem. Phys. 142, 084110 (2015).
4. K. Kaasbjerg and A. Nitzan, Theory of light emission from quantum
noise in plasmonic contacts: above-threshold, emission from higherorder electron-plasmon scattering, Phys. Rev. Letters, 114, 126803
(2015)
5. W. Dou, A. Nitzan and J. E. Subotnik, Surface hopping with a manifold
of electronic states, III: transients, broadening and the Marcus picture,
J. Chem. Phys. 142, 234106 (2015).
RESEARCHERS
Dr. Roey J. Amir
Web: http://chemistry.tau.ac.il/roeyamir/
Research Title
Smart polymers
Stimuli-responsive nanocarriers that can disassemble
to release their encapsulated cargo upon external
stimuli have gained increasing attention due to their
possible utilization as smart drug delivery systems.
Among the various types of stimuli, enzymes offer
great potential for the activation of biomedical
carriers, due to their overexpression in various
diseases. The design of enzyme-responsive block
copolymers is highly challenging, as the enzyme
must reach the enzyme-sensitive moieties - which
are spread along the backbone of the polymer, and
might be hidden inside the hydrophobic cores of the
self-assembled structures. The polydispersity of the
stimuli-responsive block raises another significant
challenge for the kinetic analysis and mechanistic
study of the enzymatic response, as the enzyme’s
access to the enzymatically activated moieties can
vary greatly - depending on their location along the
polymer backbone, the length of the polymer chain,
and its solubility. To address these challenges, we
are developing highly modular polymeric platforms
based on amphiphilic PEG-dendron hybrids. These
amphiphilic hybrids can self-assemble in water
into micellar nanocontainers that disassemble
and release encapsulated molecular cargo upon
enzymatic activation. The modularity of these PEGdendron hybrids offers great control and tuning of
the disassembly rate of the formed micelles, through
simple adjustment of the PEG’s length. Such smart
amphiphilic hybrids could open the way for the
fabrication of nanocarriers with tunable release
rates for drug delivery applications.
1. Harnoy, Assaf J.; Rosenbaum, Ido; Tirosh, Einat; Ebenstein, Yuval;
Shaharabani, Rona; Beck, Roy; Amir, Roey J., Enzyme-Responsive
Amphiphilic PEG-Dendron Hybrids and Their Assembly into Smart
Micellar Nanocarriers, Journal of the American Chemical Society
(2014), 136, 7531-7534.
2. Rosenbaum, Ido; Harnoy, Assaf J.; Tirosh, Einat; Buzhor Marina; Segal,
Merav; Frid, Liat; Shaharabani, Rona; Avinery, Ram; Beck, Roy; Amir,
Roey J., Encapsulation and covalent binding of molecular payload
in enzymatically activated micellar nanocarriers, Journal of the
American Chemical Society (2015), 137, 2276-2284.
3. Buzhor, Marina; Harnoy, Assaf J.; Tirosh, Einat; Barak, Ayana; Schwartz,
Tal; Amir, Roey J., Supramolecular translation of enzymatically
triggered disassembly of micelles into tunable fluorescent responses,
Chemistry - A European Journal (2015), 21, 15633–15638.
4. Amir, Roey J., Enzyme-Responsive PEG-Dendron Hybrids as Platform
for Smart Nanocarriers, Synlett (2015), 26 (19), 2617-2622.
5. Buzhor, Marina; Avram, Liat; Frish, Limor; Cohen, Yoram; Amir, Roey
J., Fluorinated Smart Micelles as Enzyme-responsive Probes for
19F-Magnetic Resonance, Journal of Materials Chemistry B (2016),
Advance Article DOI: 10.1039/C5TB02445E.
RESEARCHERS
Prof. Dan Peer
Web: http://www3.tau.ac.il/danpeer/
Research Title
Nanomedicine
Our lab searches for ways to manipulate cells’
functions in order to generate novel strategies
for the treatment of inflammatory diseases and
cancers. In addition, we develop nanomedicines
by designing highly selective targeting moieties
and novel nanocarriers. Work at the lab is based
on a multidisciplinary approach, which combines
immunology, cell and molecular biology,
genetics, protein engineering, material sciences,
nanotechnology and computational techniques.
Our ultimate goal is translating some of our findings
into drugs and therapeutics for clinical settings.
We are particularly interested in:
• Developing novel strategies for targeted drug
delivery
• Probing and manipulating the immune system
with nanomaterials
• Developing non-invasive theranostic systems for
inflammatory bowel diseases and blood cancer
• Studying the role of cell cycle regulators during
inflammatory bowel diseases and blood cancers
• Investigating novel cancer multidrug resistance
inhibitors
• Studying novel approaches to target adult stem
cells (hematopoietic, bulge, cancer)
• Harnessing RNAi as a tool for drug discovery and
therapeutic applications
• Developing tools to study immuno-nanotoxicity
• Investigating polysaccharides as building blocks
for nanotherapeutics
1. S. Weinstein, I.A. Toker, R. Emmanuel, S. Ramishetti, I. Hazan-Halevy,
D. Rosenblum, M. Goldsmith, A. Abrahamc, O. Benjamini, O. Bairey,
P. Raanani, A. Nagler, J. Liebermane,and D. Peer. (2016) Harnessing
RNAi based-nanomedicines for therapeutic gene silencing in B cell
malignancies. Proc. Natl. Acad. Sci. USA 113(1) E16-E22.
2. Dearling, J., Daka, A., Veiga, N., Peer, D., and Packard A. (2016)
ImmunoPET of colitis: defining target cell populations and optimizing
pharmacokinetics. Inflammatory Bowel Diseases. 22(3):529-538.
3. Ramishetti S., Kedmi R., Goldsmith M., Leonard F., Speague AG.,
Godin B., Gozin M., Cullis P., Dykxhoorn DM., and Peer D (2015)
Systemic Gene Silencing in Primary T lymphocytes using Targeted
Lipid Nanoparticles. ACS Nano.
4. Cohen ZR, Ramishetti S, Peshes-Yaloz N, Goldsmith M, Wohl A,
Zibly Z, and Peer D (2015). Localized RNAi Therapeutics of ChemoResistant Grade IV Glioma using Hyaluronan-Grafted Lipid-Based
Nanoparticles. ACS Nano. 9(2), 1581-1591.
5. Singh M.S., Peer D. (2016) RNA nanomedicines: the next generation
drugs? Current Opinion in Biotechnology 28-34.
RESEARCHERS
Prof. Ronit Satchi-Fainaro
Tel: 972-3-6407427
Web: http://medicine.mytau.org/satchi-fainaro/
Research Title
Cancer angiogenesis and nanomedicine research
Our research focuses on the field of nanomedicine
and angiogenesis (cancer and vascular biology).
We have major expertise in tumor biology, tumor
dormancy, angiogenesis, molecular imaging, noninvasive intravital imaging of animal models and
personalized nanomedicines for cancer theranostics
(therapy and diagnostics). Throughout our work
we have maintained an interest in understanding
the biological rationale for the design of
nanomedicines suitable for transfer to clinical
testing. Our multidisciplinary laboratory focuses
on basic research elucidating the mechanisms
underlying the switch from dormancy, leading to
the discovery of new molecular targets interrupting
tumor-host interactions. This research is followed by
the design of highly-selective targeting molecules
integrating biology, chemistry, protein engineering,
molecular imaging, computational approaches,
material sciences and nanotechnology, to selectively
guide drugs into pathological sites.
1. Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek
P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y,
Aviel-Ronen S, Barshack I, Calderón M, Haag R and Satchi-Fainaro R,
Identification of Dormancy-Associated MicroRNAs for the Design
of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes,
ACS Nano 10(2): 2028-2045 (2016).
2. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R,
Caliceti P. Novel Pullulan Bioconjugate for Selective Breast Cancer
Bone Metastases Treatment. Bioconjug Chem 2015, 18;26(3):489-501.
3. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R,
Caliceti P. Novel Pullulan Bioconjugate for Selective Breast Cancer
Bone Metastases Treatment. Bioconjug Chem 2015, 18;26(3):489-501.
4. Fisusi FA, SiewPHARMACEUTICAL_Cover A, Chooi KW, Okubanjo
O, Garrett N, Lalatsa K, Serrano D, Summers I, Moger J, Stapleton P,
Satchi-Fainaro R, Schätzlein AG, Uchegbu IF, Lomustine Nanoparticles
Enable Both Bone Marrow Sparing and High Brain Drug Levels – A
Strategy for Brain Cancer Treatments, Pharmaceutical Research
33(5):1289-1303 (2016).
5. Redy-Keisar O, Ferber S, Satchi-Fainaro R, Shabat D. NIR Fluorogenic
Dye as a Modular Platform for Prodrug Assembly: Real-Time in vivo
Monitoring of Drug Release. ChemMedChem. 2015 10(6):999-1007.
RESEARCHERS
Prof. Inna Slutsky
Web: http://www.slutskylab.com/
Research Title
Neuronal plasticty
The long-term goal of our study is to understand
cellular, molecular and network-wide mechanisms
underlying the transition from normal brain
physiology to Alzheimer’s disease (AD) pathology.
Utilizing an integrated system that combines FRET
spectroscopy / 2photon-FLIM, high-resolution
optical imaging, electrophysiology, molecular
biology and biochemistry, we explore the casual
relationships between ongoing neuronal activity,
structural rearrangements within synaptic signaling
complexes and plasticity of individual neurons, and
the whole neural network. This integrated system
has enabled us to identify new principles and novel
molecular targets that critically influence synaptic
and memory functions, initiating AD-associated
synaptic dysfunctions. Specifically, we have
identified hyperactivity of excitatory hippocampal
synapses as a primary mechanism initiating synaptic
dysfunctions, and have also found the mechanism
underlying these synaptic changes.
We believe that the integrated system we
have developed to measure structure-function
relationships at the single synapse level may
contribute to a better understanding of the initiation
of AD-related neuronal and synaptic dysfunctions,
ultimately leading to a new therapeutic approach by
reversing hippocampal hyperactivity in Alzheimer’s
patients.
1. Gazit, N., Vertkin, I., Shapira, I., Helm, M., Slomowitz, E., Sheiba, M.,
Mor, Y., Rizzoli, S., and Slutsky, I. (2016) IGF-1 Receptor Differentially
Regulates Spontaneous and Evoked Transmission via Mitochondria
at Hippocampal Synapses, Neuron 89, 583-597.
2. Frere, S. and Slutsky, I. (2016) Targeting PTEN interactions for
Alzheimers disease, Nature Neuroscience 19, 416-418.
3. Vertkin, I., Styr, B., Slomowitz, E., Ofir, N., Shapira, I., Berner, D., Fedorova,
T., Laviv, T., Barak-Broner, N., Greitzer-Antes, D., Gassmann, M., Bettler,
B., Lotan, I., and Slutsky, I. (2015) GABAB receptor deficiency causes
failure of neuronal homeostasis in hippocampal networks, Proc Natl
Acad Sci U S A 112, E3291-3299.
4. Slomowitz, E., Styr, B., Vertkin, I., Milshtein-Parush, H., Nelken, I., Slutsky,
M., Slutsky, I. (2015). Interplay between population firing stability
and single neuron dynamics in hippocampal networks. Elife 4.
RESEARCHERS
Prof. Rimona Margalit
Web: none
Research Title
Biomaterial-based targeted carriers for theranostics of cancer
and inflammation
Our group applies three lipid-based particulate
drug carriers for theranostics of major pathology
classes - all invented and developed ‘in-house’.
Four such projects are currently running at the
lab, and each project includes three stages: (i)
Formulation studies – making the drug-carrier
systems and characterizing them through structural
and physicochemical studies; (ii) In vitro studies
in cultures of the relevant target and control cell
lines, pursuing safety and retention of therapeutic
activity of the carrier-encapsulated drug; and (iii) In
vivo studies in appropriate animal models, pursuing
safety and efficacy.
Our current projects include:
1) Inhalational treatment of respiratory damage by
aerosols of hyaluronan-liposomes encapsulating
anti-inflammatory and anti-oxidant drugs - a single
drug or both in the same liposome. This is currently
at the in vivo stage, evaluating safety and efficacy
in a mouse model for acute lung inflammation.
2) Theranostics of heart inflammation (post
myocardial infarction) by macrophage-targeted
liposomes encapsulating iron nanoparticles, iron
complexes or steroids. This project, conducted in
collaboration with Prof. J. Leor from TAU’s Faculty
of Medicine, is currently at the in vitro and in vivo
stages.
3) Cancer theranostics, directed at both the cancer
cells and the tumor-associated macrophages,
by hyaluronan-liposomes encapsulating iron
complexes. This study, also in collaboration with
Prof. J. Leor, is now at the in vitro and in vivo stages.
4) Treatment of osteoarthritis via local injection,
by a collagen-based carrier encapsulating antiinflammatory drugs. This is in the initial stage of
formulation studies.
1. Ben-Mordechai T, Palevsky D, Glucksam-Galnoy Y, Elron-Gross I,
Margalit R, Leor J (2015) Targeting Macrophage Subsets for Infarct
Repair. 2015). Targeting Macrophage Subsets for Infarct Repair.
Journal of Cardiovascular Pharmacology and Therapeutics 20, 36-51.
2. Ilia Rivkin, Yifat Galnoy-Glucksam, Inbar Elron-Gross, Amichay Afriat,
Arik Eisenkraft, Rimona Margalit (2016) Treatment of respiratory
damage in mice by aerosols of drug-encapsulating targeted lipidbased particles. Journal of Cont. Rel. in publication, on line April 2016
3. Rimona Margalit and Dan Peer (2016). Lipidated glycosaminoglycan
particles and their use in drug and gene delivery for diagnosis and
therapy. US patent # 9,259,474
RESEARCHERS
Prof. Ehud Gazit
Affiliation: Molecular Microbiology and Biotechnology Department
Web: https://en-lifesci.tau.ac.il/profile/ehudg
Research Title
Molecular self-assembly of biological, bio-inspired and other
organic building blocks
The work in our group focuses on the molecular
self-assembly of biological, bio-inspired and other
organic building blocks, a key process in chemistry
and biochemistry. We apply a minimalistic approach
to define the smallest molecular recognition
and assembly modules, and understand the
physicochemical basis for their association. We
study the organization of biological systems in
diverse fields, including amyloid diseases such as
Alzheimer’s disease and Parkinson’s disease, diabetes,
viral diseases and metabolic disorders. We have
identified the ability of very short peptides, as well
as metabolites, to form typical amyloidal nanofibrils. Our study of minimal recognition modules
has led to the discovery of a family of dipeptide
nanostructures of various architectures, including
nanotubes, nanospheres, nanoplates and hydrogel,
with nanoscale order and unique mechanical, optical,
piezoelectric and semiconductive properties. These
various assemblies form from remarkably simple
building blocks that can potentially be synthesized
in large quantities at a low cost. We demonstrated
how these peptide nanostructures can be used
as casting molds for the fabrication of metallic
nano-wires and coaxial nanocables. We used inkjet
technology as well as vapor deposition methods
to coat surfaces and form peptide “nano-forests”
in a highly controlled manner. We are currently
employing microfluidic techniques to enable the
formation of assembled products with specific size
distribution, while controlling the assembly kinetics.
We recently extended our studies to peptide nucleic
acids (PNA), thereby converging the fields of peptide
nanotechnology and DNA nanotechnology.
1. Fichman, G., Guterman, T., Damron, J., Adler-Abramovich, L., Schmidt,
J., Kesselman, E., Shimon, L.J., Ramamoorthy, A., Talmon, Y., Gazit, E.
(2016). Spontaneous structural transition and crystal formation in
minimal supramolecular polymer model. Science Adv. 2, e1500827.
2. Berger, O., Adler-Abramovich, L., Levy-Sakin, M., Grunwald, A.,
Liebes-Peer, Y., Bachar, M., Buzhansky, L., Mossou, E., Forsyth, V.T.,
Schwartz, T., Ebenstein, Y., Frolow, F., Shimon, L.J.W., Patolsky, F.,
Gazit, E. (2015). Light-Emitting Self-Assembled Peptide Nucleic
Acids Exhibit Both Stacking Interactions And Watson-Crick Base
Pairing. Nature Nanotech. 10, 353-360.
3. Mondal, S., Adler-Abramovich, L., Lampel, A., Bram, Y., Lipstman, S.,
Gazit, E. (2015). Formation Of Functional Super-Helical Assemblies
By Constrained Single Heptad Repeat. Nature Commun. 6, 8615.
4. Levin, A., Mason, T.O., Adler-Abramovich, L., Buell, A.K., Meisl, G.,
Galvagnion, C., Bram, Y., Stratford, S.A., Dobson, C.M., Knowles,
T.P.J., Gazit, E. (2014). Ostwald’S Rule Of Stages Governs Structural
Transitions And Morphology Of Dipeptide Supramole.
5. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Magno, A., Caflisch,
A., Frenkel, D., Gazit, E. (2012). Phenylalanine Assembly Into Toxic
Fibrils Suggests Amyloid Etiology In Phenylketonuria. Nature Chem.
Biol. 8, 701-706.
RESEARCHERS
Dr. Tal Ellenbogen
Web: http://www.eng.tau.ac.il/~tal/neolab/
Research Title
Nanoscale light-matter interaction
We study the fundamentals of the interaction
between light and matter at the nanoscale, in order
to gain a better understanding of the underlying
physical mechanisms of this interaction, and use
it to develop the next generation of optical and
electro-optical devices.
Our research involves: extensive fabrication and
design of novel nanostructured materials for optical
and electro-optical applications; characterization
of the interaction of these materials with laser
beams and incoherent light; and the development
of relevant analytical or numerical models and
simulations.
The lab’s active lines of research and development
currently include: stimulated emission effects in nanocomplexes; emission control and synchronization for
optical computing and lab-on-a-chip applications;
nonlinear plasmonic metamaterials for optical wave
mixing applications; hybrid light-matter excitations
based on strongly coupled exciton-plasmonpolaritons and waveguide-exciton-polaritons
as means for developing all-optical and electrooptical switches, coherent light sources and optical
amplifiers; optical elements based on metamaterials
and nano-antennas for consumer electronics and
imaging devices; and new structured surfaces for
interferometric microscopy.
1. N. Segal, S. Keren-Zur, N. Hendler, T. Ellenbogen, Controlling light with
metamaterial-based nonlinear photonic crystals, Nature Photonics
9, 180-184(2015).
2. E. Eizner, O. Avayu, R. Ditcovski, T. Ellenbogen, Aluminum Nanoantenna
Complexes for Strong Coupling between Excitons and Localized
Surface Plasmons, Nano Letters 15, 6215-6221(2015).
3. O. Avayu, O. Eisenbach, R. Ditcovski and T. Ellenbogen, Optical
Metasurfaces for Polarization Controlled Beam Shaping, Optics
Letters 39, 3892-3895 (2014).
4. Marcel Rey, Roey Elnathan, Ran Ditcovski, Karen Geisel, Michele
Zanini, Miguel A Fernandez-Rodriguez, Vikrant V. Naik, Andreas
Frutiger, Walter Richtering, Tal Ellenbogen, Nicolas H. Voelcker, and
Lucio Isa, Fully Tunable Silicon Nanowire Arrays by Soft
5. Shay Keren-Zur, Ori Avayu, Lior Michaeli, and Tal Ellenbogen Nonlinear
beam shaping with plasmonic metasurfaces, ACS Photonics 3,
117-123 (2016).
RESEARCHERS
Prof. Jacob Scheuer
Web: www.eng.tau.ac.il/~kobys/
Research Title
Nano-photonic devices and applications
Nano-Photonics deals with the interaction of light
and matter at the nanoscale. This research field is
of fundamental scientific importance, while also
providing a main route to novel technologies
and applications - such as sensing, solar energy
harvesting, telecommunications and optical
computing.
Specifically in our lab we focus on the development
of nano-antennas for optical frequencies, which have
applications in many different areas: solar energy
harvesting, controlled self-assembly and beam
shaping, nano semiconductor lasers for sensing and
telecommunications, and secure communications
using fiber lasers and polymer optics.
1. G. Kaplan, K. Aydin and J. Scheuer, Dynamically controlled plasmonic
nano-antenna phased array utilizing vanadium dioxide, Opt. Mater.
Express 5, 2513-2524 (2015). (Invited).
2. E. Ben Bassat and J. Scheuer, Optimal design of radial Bragg cavities
and lasers, Opt. Lett. 40, 3069-3072 (2015).
3. M. Eitan, Z. Iluz, Y. Yifat, A. Boag, Y. Hanein, and J. Scheuer, Degeneracy
Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing,
ACS Photon. 2, 615−621 (2015).
4. D. Bar-Lev, A. Arie, J. Scheuer, and I. Epstein, Efficient excitation and
control of arbitrary surface plasmon polariton beams using onedimensional metallic gratings, J. Opt. Soc. Am. B 32, 923-932 (2015).
5. J. Scheuer and Y. Yifat, Metasurfaces make it practical, Nature
Nanotech. 10, 296-298 (2015).
RESEARCHERS
Dr. Yossi Lereah
Web: http://www.eng.tau.ac.il/~lereah/
Research Title
Application of TEM in quantum mechanics
Recent progress in the fabrication of artificial
structures at the nanometer scale enable us to
transform the established knowledge from light
optics into electron beams. The transmission
electron microscope contains the required optical
element. However, the commercial systems are
constructed for microscopy. Accordingly, it is
necessary to modify the operation of the microscope
via various methods, e.g. free lens control.
1. Noa Voloch-Bloch, Yossi Lereah, Yigal Lilach, Avraham Gover and Ady
Arie Generation of electron Airy beams, Nature, 494 331-335,(2013).
2. A. Be’er, R. Kofman, F. Phillipp and Y. Lereah, Spontaneous
crystallographic instabilities of Pb nanoparticles in a SiO matrix,
Physical Review B 76 075410 (2007).
3. Y. Lereah, R. Kofman, J.M. Penisson, G. Deutscher, P. Cheyssac, T. Ben
David and A. Bourret, Time Resolved Electron Microscopy Studies
of the Structure of Nanoparticles and Their Melting, Philosophical
Magazine (invited paper), 81, 1801 (2001).
4. Y. Lereah, Pattern Formation and Interface Propagation in the
Crystallization of Amorphous Alloys, Current Topics in Crystal Growth
7, 59 (2004). Invited paper.
5. Y. Lereah, E. Grunbaum and G. Deutscher, Formation of Dense
Branching Morphology in the Crystallization of Al:Ge Amorphous
Thin Films. Physical Review A 44 8316 (1991).
RESEARCHERS
Dr. Alon Bahabad
Web: http://www.eng.tau.ac.il/~alonb/
Research Title
Physical optics
Our group is interested in theoretical and
experimental research in various areas of physical
optics. One of our major areas of research is the
generation of coherent light sources at very high
photon energies (soft X-rays). For this we employ the
extreme nonlinear optical process of high-harmonicgeneration (HHG). HHG is driven with an intense
ultra-short light pulse which ionizes a gaseous
medium. The liberated electron then oscillates in
the laser field, gaining kinetic energy. There is a
small chance that the electron will encounter the
ion from which it has been liberated and recombine
with it. The excessive kinetic energy gained by the
electron is released in the form of a high energy
photon. During such a process hundreds of photons
in the laser field can be converted into a single
high-energy photon. We are interested in mediating
this process by employing Plasmon-assisted field
enhancement. When the laser light interacts with
a metallic nanostructure, electron oscillations on
the metal surface can lead to a significant field
enhancement. This can be utilized to assist with the
process of HHG. In addition, the geometry of the
metallic nanostructure can be used to control the
beam shape and polarization state of the generated
high harmonic radiation.
1. Itai Hadas and Alon Bahabad, Macroscopic manipulation of highharmonic-generation through bound-state coherent control, Physical
Review Letters, 113, 253902 (2014).
2. Yaniv Eliezer and Alon Bahabad, Super-transmission: The delivery of
superoscillations through the absorbing resonance of a dielectric
medium, Optics Express, 22, 31212-31226 (2014).
3. Mor Konsens and Alon Bahabad, Time-to-frequency mapping of
optical pulses using accelerating quasi-phase-matching, Physical
Review A, 93, 023823 (2016).
4. Alon Bahabad, Margaret M. Murnane and Henry C. Kapteyn, Quasi
Phase Matching of Momentum and Energy in Nonlinear Optical
Processes, Nature Photonics, 4, 570-575 (2010).
5. Ron Lifshitz, Ady Arie and Alon Bahabad, Photonic quasicrystals for
general purposes nonlinear optical frequency conversion, Physical
Review Letters, 95, Issue 13, 133901 (2005).
RESEARCHERS
Prof. David J. Bergman
Web: http://www2.tau.ac.il/nano/researcher.asp?id=abddjgchk
Research Title
Physical phenomena in composite media
The research in our group focuses on the followings:
1. Magneto-transport and magneto-optics in metaldielectric composite media, when the Hall resistivity
in the metallic constituent is greater than the Ohmic
resistivity
2. Nano-plasmonics in such a medium
3. Macroscopic physical phenomena in social
wasps: the exploitation of thermoelectric cooling
to regulate the body temperature of the Oriental
Hornet; the exploitation of ultrasonic acoustic
resonances by worker hornets and worker bees
in the construction of highly symmetric combs in
a hornets’ nest or beehive
1. D. J. Bergman, Perfect imaging of a point charge in the quasistatic
regime, Phys. Rev. A 89, 015801 (4 pp.) (2014).
2. D. J. Bergman and Y. M. Strelniker, Strong-field magneto-transport
in a two-constituent columnar composite medium where the
constituents have comparable resistivity tensors, Phys. Rev. B 86,
024414 (14 pp.) (2012).
3. M. Tornow, D. Weiss, K. von Klitzing, K. Eberl, D. J. Bergman, and Y.
M. Strelniker, Anisotropic Magnetoresistance of a Classical antidot
array, Phys. Rev. Lett. 77, 147{150 (1996).
4. D. J. Bergman and J. S. Ishay, Do Bees and Hornets Use Acoustic
Resonance in Order to Monitor and Coordinate Comb Construction?
Bulletin of Mathematical Biology 69(5), 1777, 1790 (2007).
5. D. J. Bergman and M. I. Stockman, Surface plasmon amplication by
stimulated emission of radiation: Quantum generation of coherent
surface plasmons in Nanosystems, Phys. Rev. Letters 90, 027402-1,
027402-4 (2003).
RESEARCHERS
Prof. Ady Arie
Web: http://www.eng.tau.ac.il/~ady/
Research Title
Nonlinear optics, plasmonics, electron microscopy
Our group is active in several areas of research:
nonlinear optics, plasmonics and electron beam
shaping.
In nonlinear optics, we mainly concentrate on
quadratic nonlinear processes in ferroelectric
crystals. The ability to modulate the quadratic
nonlinear coefficient is used for shaping the spatial
and spectral response of the nonlinear crystal.
In plasmonics, our efforts in recent years have
focused on generating special types of plasmonic
beams. To this end, we have developed special types
of couplers between free-space light beams and
plasmonic beams, applying concepts and coding
schemes developed in the field of holography.
In electron beam shaping, we utilize a recent
technological breakthrough, enabling us to shape
the phase and amplitude of electron beams by
passing them through a thin SiN membrane,
patterned by focused ion beam milling.
1. Voloch-Bloch N., Lereah Y., Lilach Y., Gover A. and Arie A. (2013).
Generation of electron Airy beams, Nature 494, 331-335 .
2. Suchowski H., Porat G. and Arie A. (2014). Adiabatic processes in
frequency conversion, Lasers and Photonics Reviews 8, 333-367
3. Epstein I. and Arie A. (2014). Arbitrary Bending Plasmonic Light
Waves, Physical Review Letters 112, 023903.
4. Remez R. and Arie A. (2015). Super-narrow frequency conversion,
Optica 2, 472-475 .
5. Shapira A., Naor L. and Arie A., (2015). Nonlinear optical holograms
for spatial and spectral shaping of light waves, Science Bulletin 60,
1403-1415.
RESEARCHERS
Prof. Amir Boag
Web: https://www.eng.tau.ac.il/~boag/
Research Title
Rectifying nano-antennas
The dramatic increase in worldwide demand for
electrical power makes it clear that the development
of clean, renewable alternative energy sources is
essential, with solar power harvesting as the leading
direction. The basic properties of conventional
photovoltaic solar cells are determined by their
materials’ chemistry and the corresponding
electronic properties. As a result, such solar cells have
inherent and fundamental limitations in terms of
optical bandwidth, efficiency and cost. On the other
hand, power harvesting utilizing RF approaches has
demonstrated high efficiency (exceeding 85%) in
the radio-frequency spectral range, as well as low
fabrication costs. The objective of our research is
to develop new detection and power conversion
schemes for optical frequencies, based on metallic
rectifying nano-antennas (rectennas). A nanorectenna includes two fundamental elements: an
antenna and a rectifier. The antenna receives the
EM wave and converts it into an alternating electric
current (AC). The rectifier converts the AC current
into a direct current (DC). We have demonstrated
the ability to design, optimize and fabricate
ultra-wideband nano-antenna arrays. We have
measured the spectral properties of the scattered
field from these antennas, and shown very good
agreement with numerical simulations. We have also
demonstrated preliminary success in integrating the
nano-antennas with the rectifiers. We now intend
to utilize these abilities to develop a new concept
for solar-power harvesting, which can revolutionize
the field by providing an inexpensive and efficient
approach for direct EM to DC power conversion.
1. Z. Iluz and A. Boag, Dual-Vivaldi wide band nano-antenna with
high radiation efficiency over the infrared frequency band, Optics
Letters, vol. 36, no 15, pp. 2773-2775, 2011.
2. E. Strassburg, A. Boag, Y. Rosenwaks, Reconstruction of Electrostatic
Force Microscopy Images, Review of Scientific Instruments, vol.76,
083705, 28 July 2005.
3. Y. Yifat, Z. Iluz, D. Bar-Lev, M. Eitan, Y. Hanein, A. Boag, and J. Scheuer,
High load-sensitivity in wideband infrared dual-Vivaldi nanoantennas,
Optics Letters, vol. 38, no. 2, pp. 205–207, 2013.
4. Y. Yifat, M. Eitan, Z. Iluz, Y. Hanein, A. Boag, and J. Scheuer, Highly
efficient and broadband Wide-Angle Holography Using PatchDipole Nano-antenna Reflectarrays, Nano Letters, March 19, 2014.
5. G. Y. Slepyan and A. Boag, Quantum non-reciprocity of nanoscale
antenna arrays in timed Dicke states, Physical Review Letters, vol.
111, 023602, 11 July, 2013.
RESEARCHERS
Dr. Moshe Goldstein
Web: http://www6.tau.ac.il/mgoldstein/
Research Title
Theory of low-dimensional nanoscale electronic and photonic
systems
My research involves the theoretical (both analytical
and numerical) study of low-dimensional/nanoscale
electronic and photonic systems, in and out of
equilibrium. Nanoscale systems are immensely
important as the basic building blocks of future
electronic devices, which may lead, among other
potential applications, to the eventual realization
of scalable quantum computing. They can be
fabricated using a variety of materials, including
semiconductor heterostructures, metallic nanowires
and nanograins (normal or superconducting),
carbon-based materials (graphene, nanotubes and
buckyballs), the recently discovered topological
insulators, and conducting polymers and single
molecules. Their behavior can also be simulated with
ultracold atoms in optical traps. Not less importantly,
from a more fundamental perspective, nanoscale
systems exhibit a variety of phenomena caused
by strong electronic correlations, as well as their
interplay with quantum interference effects and
nonequilibrium behavior, all of which are central
themes in current condensed matter research.
1. J. I. Väyrynen, M. Goldstein, Y. Gefen, and L. I. Glazman, Resistance
of helical edges formed in a semiconductor heterostructure, Phys.
Rev. B. 90, 115309 (2014), Editors’ Suggestion.
2. M. Goldstein, M. H. Devoret, M. Houzet, and L. I. Glazman, Inelastic
microwave photon scattering off a quantum impurity in a Josephsonjunction array”, Phys. Rev. Lett. 110, 017002 (2013).
3. B. Bradlyn, M. Goldstein, and N. Read, “Kubo formulas for viscosity:
Hall viscosity, Ward identities, and the relation with conductivity,
Phys. Rev. B 86, 245309 (2012), Editors’ Suggestion.
4. M. Goldstein, R. Berkovits, and Y. Gefen, Population switching and
charge sensing in quantum dots: A case for a quantum phase
transition, Phys. Rev. Lett. 104, 226805 (2010).
5. M. Goldstein and R. Berkovits, Duality between different geometries
of a resonant level in a Luttinger liquid, Phys. Rev. Lett. 104, 106403
(2010).
RESEARCHERS
Prof. Yoram Dagan
Web: http://minerva.tau.ac.il/dagan/index.html
Research Title
Emergent phenomena at surfaces and interfaces
Recent developments in thin-film fabrication
techniques have enabled the deposition of newly
designed and well controlled oxide interfaces. These
interfaces can have properties which are significantly
different from their constituent materials. Correlated
electrons in oxide interfaces result in a variety of
properties, such as metal-insulator transition,
superconductivity and magnetism, and these phase
transitions can be tuned by external stimuli such as
electric and magnetic fields and pressure. The ability
to tune the phase transitions makes these interfaces
particularly interesting - both from the perspective
of basic science, and as potential components for
future electronic devices. Of particular interest
are new interfaces that can be used in future
applications, such as spin-controlled electronics
(spintronics) and quantum computation. Other
fascinating examples are interfaces where multiple
orders may coexist, such as: superconductivity
coexisting with magnetism, which can result in
an exotic symmetry of the superconducting orderparameter, and ferromagnetism coexisting with
ferroelectricity. Interface design has been proven
successful in enhancing macroscopic orders, e.g.
superconductivity, ferroelectricity and combining
orders. Our challenge is to master these interfaces,
understand them and use them as a platform for
observation of exotic physical phenomena, as well
as for new applications.
1. M. Ben Shalom, M. Sachs, D. Rakhmilevitch, A. Palevski and Y. Dagan,
Tuning spin-orbit coupling and superconductivity at the SrTiO3/
LaAlO3 interface: a magneto-transport study, Phys. Rev. Lett. 104,
126802 (2010).
2. A. Ron and Y. Dagan, One-dimensional quantum wire formed at
the boundary between two insulating LaAlO3/SrTiO3 interfaces,
Phys. Rev. Lett. 112, 136801 (2014).
3. E. Lahoud, E. Maniv, M. Shaviv, M. Naamneh, A. Ribak, S. Wiedmann,
L. Petaccia, Z. Salman, K. B. Chashka, Y. Dagan, A. Kanigel, Evolution
of the Fermi surface of doped topological insulator with carrier
concentration, Phys. Rev. B 88, 195107 (2013).
4. Itai Carmeli et al. and Yoram Dagan, Tuning the Critical Temperature
of Cuprate Superconductor Films with Self‐Assembled Organic
Layers, Angewandte Chemie International Edition, 51, 7162 (2012).
5. E. Maniv, M. Ben Shalom, A. Ron, M. Goldstein, A. Palevski, and Y.
Dagan, Strong correlations elucidate the electronic structure and
phase-diagram of LaAlO3/SrTiO3 interface , Nature Communications
6, 8239 (2015).
RESEARCHERS
Prof. Alexander Gerber
Web: N/A
Research Title
Hall effect spintronics
Spintronics is an emerging field of basic and applied
research in physics and engineering, in which the
electron’s magnetic degree of freedom - its spin
- may be exploited for classical and quantum
information processing. Carrying information in
both the charge and spin of an electron potentially
enables devices with greater functional diversity.
Our research focuses mainly on the spin-dependent
Hall effect in a variety of artificial nanoscale materials,
and on its application in a new generation of
magnetic sensors, magnetic random access
memories and logic devices.
1. Milner A., Gerber A., Karpovsky M. and Gladkikh A. (1996). Spin Dependent Electronic Transport in Granular Ferromagnets. Phys.
Rev. Lett. 76, 475 - 478.
2. Gerber A. (2007). Towards Hall Effect Spintronics. Jour. Magn. Magn.
Matt., 310, 2749.
3. Segal A., Gerber A. and Karpovski M. (2011). Sixteen-states magnetic
memory based on the extraordinary Hall effect. J. Magn.Magn.
Matt. 324, 1557.
4. Simons A., Gerber A., Korenblit I.Ya., Suslov A., Raquet B., Passacantando
M., Ottaviano L., Impellizzeri G., Aronzon B. (2014). Components of
strong magnetoresistance in Mn implanted Ge. J. Appl. Phys. 115,
093703
5. Winer G., Segal A., Karpovski M., Shelukhin V., and Gerber A. (2015).
Probing Co/Pd interfacial alloying by the extraordinary Hall effect.
J. Appl. Phys. 118, 173901.
RESEARCHERS
Dr. Guy Cohen
Web: www.tau.ac.il/~gcohen/
Research Title
Computational methods for nonequilibrium quantum manybody systems
Our group investigates nonequilibrium phenomena
in chemical and condensed matter physics. We try
to understand how strongly correlated quantum
systems react to dissipative environments and to
external perturbations, particularly in the context
of the transport properties of nanosystems. This is a
deeply challenging and fundamental problem, and
we therefore work on state-of-the-art computational
methods such as quantum Monte Carlo algorithms.
We focus on methods for circumventing the
dynamical sign problem, a phenomenon which
usually prevents Monte Carlo methods from
accessing nonequilibrium physics and dynamics.
1. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., 2015. Taming the
dynamical sign problem in real-time evolution of quantum manybody problems. Phys. Rev. Lett. 115, 266802 .
2. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., 2014. Green’s Functions
from Real-Time Bold-Line Monte Carlo Calculations: Spectral
Properties of the Nonequilibrium Anderson Impurity Model. Phys.
Rev. Lett. 112, 146802.
3. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., Rabani, E., 2013.
Numerically exact long-time magnetization dynamics at the
nonequilibrium Kondo crossover of the Anderson impurity model.
Phys. Rev. B 87, 195108.
4. Cohen, G., Rabani, E., 2011. Memory effects in nonequilibrium
quantum impurity models. Phys. Rev. B 84, 075150
5. Mocatta, D., Cohen, G., Schattner, J., Millo, O., Rabani, E., Banin, U.,
2011. Heavily Doped Semiconductor Nanocrystal Quantum Dots.
Science 332, 77 –81
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RESEARCHERS
Prof. Alexander Palevski
Web: http://www.tau.ac.il/~apalev/
Research Title
Quantum electronic transport in low dimensional systems
Our research involves quantum electronic transport
in condensed matter systems at low temperatures.
Topics are quite diverse, spanning many areas of
modern solid state physics: superconductivity,
ferromagnetism, the Quantum Hall effect and
mesoscopic physics. Due to the diversity of
subjects, the materials investigated also cover a
broad range of solids: normal metals, ferromagnets,
semiconductors, topological insulators and
superconductors. The common denominator of
the devices made of these material systems at our
lab is low dimensionality - a vast majority of the
experimentally studied electronic systems are either
two- or one-dimensional. The low dimensions of the
devices fabricated in the lab are achieved via stateof-the-art nanofabrication techniques, including
photolithography, electron beam lithography,
focused ion beam microscopy and more.
In recent years research at the lab has focused mainly
on the following topics: (1) Mesoscopic phenomena
and superconductivity in two-dimensional electron
gas formed at the interface between the two large
gap insulators SrTiO3/LaAlO3 and in topological
insulators BiSe3. Quantum interference effects were
observed and analyzed, allowing us to establish
the dephasing mechanism in these exotic systems.
(2) The electronic correlations in InAs and GaAs
semiconductor nanowires. The role of the electronelectron interaction was elucidated, and the so-called
Luttinger liquid model was demonstrated as the
adequate theory for transport in quantum nanowires.
(3) Spin-orbit interaction and its effect on quantum
transport in nanowires, and the role played in
quantum interference phenomena in Aharonov
Bohm rings. Currently we are studying the effect
of the spin orbit interaction on Luttinger parameter
on Berry phase in these systems.
1. R. Hevroni, V. Shelukhin, M. Karpovski, M. Goldstein, E. Sela, Hadas
Shtrikman and A. Palevski (2016). Suppression of Coulomb blockade
peaks by electronic correlations in InAs nanowires, Phys. Rev. B 93,
035305.
2. E. Maniv, M. Ben Shalom, A. Ron, M. Mograbi, A. Palevski, M. Goldstein,
and Y. Dagan (2015). Strong correlations elucidate the electronic
phase-diagram of LaAlO3/SrTiO3 interface, Nature Communications,
6, 8239.
3. Qi I. Yang, Merav Dolev, Li Zhang, Jinfeng Zhao, Alexander D. Fried,
Elizabeth Schemm, Min Liu, Alexander Palevski, Ann F. Marshall,
Subhash H. Risbud, and Aharon Kapitulnik (2013). Emerging weak
localization effects on a topological insulator–insulating ferromagnet
(Bi2Se3-EuS) interface.Phys. Rev. B 88, 081407(R).
4. Nicholas P. Breznay, Hanno Volker, Alexander Palevski, Riccardo
Mazzarello, Aharon Kapitulnik, and Matthias Wuttig (2012). Weak
antilocalization and disorder-enhanced electron interactions in
annealed films of the phase-change compound GeSb2Te4. Phys.
Rev. 73.
5. I. Sternfeld, E. Levy, M. Eshkol, A. Tsukernik, M. Karpovski, Hadas
Shtrikman, A. Kretinin, and A. Palevski, (2011). Magnetoresistance
Oscillations of Superconducting Al-Film Cylinders Covering InAs
Nanowires below the Quantum Critical Point, Phys. Rev. Lett
RESEARCHERS
Prof. Ilan Goldfarb
Tel: 972-3-6407079
Web: http://www.eng.tau.ac.il/~ilang
Research Title
Epitaxial nanostructures
Self-assembled nanostructures are interesting from
the structural-morphological standpoint, and also
due to their unusual physical properties. In my
laboratory we explore the self-assembled formation
and mesoscopic ordering mechanisms of epitaxial
nano-island arrays on surfaces, primarily with the aid
of a time-resolved scanning tunneling microscope
(STM), and the way these growth mechanisms affect
the resulting physical properties. For example,
we have recently found that some metal-silicon
compounds which are non-magnetic in their bulk
form, can exhibit interesting magnetic properties
when grown as self-ordered nano-islands, and that
these properties can be further tuned by controlling
the size and geometry of the nano-island arrays.
1. I. Goldfarb, D. A. A. Ohlberg, J. P. Strachan, M. D. Pickett, J. J. Yang,
G. Medeiros-Ribeiro, R. S. Williams, Band offsets in transition-metal
oxide heterostructures, J. Phys. D - Appl. Phys. 46, 295303 (2013).
2. J.K. Tripathi, G. Markovich, I. Goldfarb, Self-Ordered Magnetic α-FeSi2
Nano-Stripes on Si(111), Appl. Phys. Lett. 102, 251604 (2013).
3. G. Cohen-Taguri, O. Sinkevich, M. Levinshtein, A. Ruzin, and I. Goldfarb,
Atomic structure and electrical properties of In(Te) nano-contacts
on CdZnTe(110) by scanning probe microscopy, Adv. Funct. Mater.
20(2) 215-223 (2010).
4. I. Goldfarb, Step-mediated size-selection and ordering of
heteroepitaxial nanocrystals, Nanotechnology 18, 335304 (2007).
5. I. Goldfarb, Effect of strain on the appearance of subcritical nuclei
of Ge nanohuts on Si(001), Phys. Rev. Lett. 95, 025501-4 (2005).
PUBLICATIONS
Publications
1.
2.
3.
4.
5.
6.
Nurit Atar, Eitan Grossman, Irina
Gouzman, Asaf Bolker, Vanessa
J. Murray, Brooks C. Marshall,
Min Qian, Timothy K. Minton,
Yael Hanein, Atomic Oxygen
Durable and ElectricallyConductive CNT POSS Polyimide
Flexible Films for Space
Applications, ACS Appl. Mater.
Interfaces,5b02200,DOI:10.1021/
acsami., (2015).
Nurit Atar, Eitan Grossman,
Irina Gouzman, Asaf Bolker,
and Yael Hanein, Reinforced
Carbon Nanotubes as
Electrically Conducting and
Flexible Films for Space
Applications, ACS Appl. Mater.
Interfaces,505811g,DOI:
10.1021/am, (2014).
Ariel J. Ben-Sasson, Daniel
Azulai, Hagit Gilon, Antonio
Facchetti, Gil Markovich, Nir
Tessler,Self-Assembled Metallic
Nanowire-Based Vertical
Organic Field-Effect Transistor,
ACS Applied Materials and
Interfaces,7,2149–2152, (2015).
Ayala Lampel, Yaron Bram, Anat
Ezer, Ronit Shaltiel-Kario, Jamil
S. Saad, Eran Bacharach, Ehud
Gazit,Targeting the Early Step
of Building Block Organization
in Viral Capsid Assembly, ACS
Chemical Biology,10,1785–1790,
(2015).
Michal Pellach, Yoav AtsmonRaz, Eyal Simonovsky, Hugo
Gottlieb, Guy Jacoby, Roy Beck,
Lihi Adler-Abramovich, Yifat
Miller, Ehud Gazit,Spontaneous
Structural Transition in
Phospholipid-Inspired
Aromatic Phosphopeptide
Nanostructures, ACS
nano,9,4085-4095, (2015).
Michal Pellach, Yoav AtsmonRaz, Eyal Simonovsky, Hugo
Gottlieb, Guy Jacoby, Roy Beck,
Lihi Adler-Abramovich, Yifat
Miller, Ehud Gazit,Spontaneous
Structural Transition in
Phospholipid-Inspired
Aromatic Phosphopeptide
Nanostructures, ACS
Nano,9,4085–4095, (2015).
7. Ramishetti S.*, Kedmi R.*,
Goldsmith M., Leonard F.,
Speague AG., Godin B., Gozin
M., Cullis P., Dykxhoorn DM., and
Peer D ,Systemic gene silencing
in primary T lymphocytes using
targeted lipid nanoparticles.,
ACS Nano,9(7),6706-6716,
(2015).
8. Cohen ZR*, Ramishetti S*,
Peshes-Yaloz N*, Goldsmith
M, Wohl A, Zibly Z, and Peer D
,Localized RNAi therapeutics of
chemo-resistant grade IV glioma
using hyaluronan-grafted
lipid-based nanoparticles., ACS
Nano,9(2),1581-1591, (2015).
9. O. Hazut, B.C. Huang, A. Pantzer,
I. Amit, Y. Rosenwaks, A. Kohn,
C.-S. Chang, Y.-P. Chiu, and
R. Yerushalmi,Parallel p-n
Junctions across Nanowires by
One-Step Ex Situ Doping, ACS
nano,8,8357–8362, (2014).
10. Ramishetti, Srinivas; Kedmi,
Ranit; Goldsmith, Meir; Leonard,
Fransisca; Sprague, Andrew G.;
Godin, Biana; Gozin, Michael;
Cullis, Pieter R.; Dykxhoorn,
Derek M.; Peer, Dan ,Systemic
gene silencing in primary T
lymphocytes using targeted
lipid nanoparticles., ACS
Nano,9(7),6706-6716, (2015).
11. M. Eitan, Z. Iluz, Y. Yifat*,
A. Boag, Y. Hanein, and J.
Scheuer,Degeneracy Breaking of
Wood’s Anomaly for Enhanced
Refractive Index Sensing, ACS
Photonics,2,615−621 , (2015).
12. Michal Eitan , Zeev Iluz ,
Yuval Yifat , Amir Boag ,
Yael Hanein , and Jacob
Scheuer,Degeneracy breaking of
Wood›s anomaly for enhanced
refractive index sensing,
13.
14.
15.
16.
17.
18.
ACS Photonics,5b00091,DOI:
10.1021/acsphotonics, (2015).
Michal Eitan, Zeev Iluz, Yuval
Yifat, Amir Boag, Yael Hanein,
and Jacob Scheuer,Degeneracy
Breaking of Wood’s Anomaly
for Enhanced Refractive Index
Sensing, ACS Photonics,2 (5)
,615–621, (2015).
A. Handelman,B. Apter,
N.Turko,Gil Rosenman,Linear
and Nonlinear Optical
Waveguiding Effects in Bioinspired Diphenylalanine
Peptide Nanotubes, Acta
Biomateriala,4,1-8, (2015).
G.I. Livshits, J. Ghabboun, N.
Borovok, A.B. Kotlyar, D. Porath
,Comparative Electrostatic
Force Microscopy of Tetra‐and
Intra‐molecular G4‐DNA , Adv.
Materials,26,4981-4985, (2014).
Dvashi Z, Shalom HJ, Shoat M,
Ben-Meir D, Ferber S, SatchiFainaro R, Ashery-Padan R,
Rosner M, Solomon AS and
Lavi S,Protein Phosphatase
Magnesium Dependent
1A governs the wound
healing-inflammationangiogenesis cross talk on
injury, American Journal of
Pathology,184,2396-2950,
(2014).
Tatyana Polenova, Rupal
Gupta, Amir Goldbourt,Magic
Angle Spinning NMR
Spectroscopy: A Versatile
Technique for Structural and
Dynamic Analysis of SolidPhase Systems, Analytical
Chemistry,87,5458-5469, (2015).
Yaron Bram, Ayala Lampel,
Ronit Shaltiel-Karyo, Anat Ezer,
Roni Scherzer-Attali, Daniel
Segal, Ehud Gazit,Monitoring
and Targeting the Initial
Dimerization Stage of Amyloid
Self-Assembly, Angewandte
Chemie International
Edition,54,2062–2067, (2015).
PUBLICATIONS
19. Cyrus R Safinya, Joanna Deek,
20.
21.
22.
23.
24.
25.
Roy Beck, Jayna B Jones, Youli
Li, Assembly of Biological
Nanostructures: Isotropic and
Liquid Crystalline Phases of
Neurofilament Hydrogels,
Annu. Rev. Condens. Matter
Phys.,6,113-136, (2015).
Alex Henning, Benjamin
Klein, Kris A. Bertness, Paul T.
Blanchard, Norman A. Sanford,
Yossi Rosenwaks,Measurement
of the electrostatic edge effect
in wurtzite GaN nanowires,
Appl. Phys. Lett.,105,213107-9,
(2014).
D. Permyakov, I. Sinev, D.
Markovich, P. Ginzburg, A.
Samusev, P. A. Belov, V. Valuckas,
A. Kuznetsov, B. Luk’yanchuk, A.
Miroshnichenko, D. Neshev, and
Y.S. Kivshar, Probing magnetic
and electric optical responses of
silicon nanoparticles, Appl. Phys.
Lett. ,106,171110, (2015).
G.Winer, A.Segal,
M.Karpovski, V.Shelukhin
and A.Gerber,Probing Co/
Pd interfacial alloying by the
extraordinary Hall effect, Appl.
Phys.Lett.,N/A,N/A, (2015).
Freeman, A., Dror, Y., Porat, C.
O., Hadar, N., & Diamand, Y. S.
,Silver-Coated Biologically Active
Protein Hybrids: Antimicrobial
Applications, Applied Mechanics
and Materials ,749,4, (2015).
Ilan Goldfarb, Stanley
Williams,Conduction centers
in a Ta2O5-delta Fermi glass,
Applied Physics A,114,287-289,
(2014).
S. Krylov, S. Lulinsky, B. R. Ilic, I.
Schneider,Collective Dynamics
and Pattern Switching in an
Array of Parametrically Excited
Micro Cantilevers Interacting
Through Fringing Electrostatic
Fields, Applied Physics
Letters,105,71909, (2014).
26. Shahar Shefer, Carlos Gordon,
27.
28.
29.
30.
31.
32.
Karen B. Avraham, Matti Mintz,
Balance deficit enhances anxiety
and balance training decreases
anxiety in vestibular mutant
mice, Behav. Brain Res.,276,7683, (2015).
Gal Herzog, Merav D. Shmueli,
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electrostatically actuated initially
curved pre-stressed micro
beams, Sensors and Actuators A:
Physical,220,323 – 332, (2014).
225. Carmit Porat-Ophir, Vladimir
Dergachev, Anton Belkin, Sefi
Vernicka, Genrietta Freynd,
Mikhail Katsnelson, Viktor
Chetvertnykh, Judith Rishpon,
Yosi Shacham-Diamand,Chip
level agitation effects on the
electrochemical sensing of
alkaline-phosphatase expressed
from integrated liver tissue,
Sensors and Actuators B:
Chemical,213,9, (2015).
226. Ragones, H., Schreiber, D.,
Inberg, A., Berkh, O., Kósa,
G., Freeman, A., & ShachamDiamand, Y. ,Disposable
electrochemical sensor
prepared using 3D printing
for cell and tissue diagnostics,
Sensors and Actuators B:
Chemical,216,9, (2015).
227. A. Henning, M. Molotskii,
N. Swaminathan, Y. Vaknin,
A. Godkin, G. Shalev, and Y.
Rosenwaks,Electrostatic Limit of
Detection of Nanowire-based
Sensors, Small,10,201500566,
(2015).
228. S. Semin,A. van Etteger,N.
Amdursky,L. Kulyuk,S.
Lavrov,A. Sigov, E. Mishina,G.
Rosenman,Th. Rasing,Strong
Thermo-Induced Single
And Two-Photon Green
Luminescence In SelfOrganized Peptide Microtubes,
Small,11,1156–1160 , (2015).
229. Micha Kornreich, Eti MalkaGibor, Adi Laser-Azogui, Ofer
Doron, Harald Herrmann, Roy
Beck,Composite bottlebrush
mechanics: α-internexin
fine-tunes neurofilament
network properties, Soft
matter,11,5839-5849, (2015).
230. Dan Ben-Yaakov, Roman
Golkov, Yair Shokef, and
Samuel A. Safran,Response of
adherent cells to mechanical
perturbations of the
surrounding matrix, Soft
Matter,11,1412, (2015).
231. Evgeny Nimerovsky, Anat
Haimovich, Amir Goldbourt,An
optimal double-magic flip
angle for performing the
distance measurement REDOR
experiment on a spin S=1,
Solid State Nuclear Magnetic
Resonance,NA,NA, (2015).
232. Ingeborg M Storm, Micha
Kornreich, Armando HernandezGarcia, Ilja K Voets, Roy Beck,
Martien A Cohen Stuart, Frans
AM Leermakers, Renko De
Vries,Liquid Crystals of SelfAssembled DNA Bottlebrushes,
The Journal of Physical
Chemistry B,119,4084-4092,
(2015).
233. Oman Walther, Itai Carmeli,
Reinhard Schneider, Dagmar
Gerthsen, Kurt Busch, Christian
Matyssek, Ayala Shvarzman,
Tsofar Maniv, Shachar Richter,
Hagai Cohen,Interslit coupling
via ultrafast dynamics across
gold-film hole arrays, The
Journal of Physical Chemistry
C,118,11043-11049, (2014).
Spinoffs
• NoAm ColorTech (2013) - A startup
Startups
• NanoLock (2015) - NanoLock’s
technology enables any solid-state
memory to be physically “locked,”
preventing unauthorized access at
the hardware level. Furthermore,
complete functionality of CPUs
and MicroControllers can also
be “locked” and disabled. Lead
researcher: Prof. Slava Krylov
• NanoAir (2014) - A startup
company developing paper-thin
active cooling for thin devices.
Lead researchers: Prof. Slava Krylov
and Prof. Yosi Shacham
• Cine’al (2014) - A startup company
developing jellyfish-derived super
absorbents for fluids, with a focus
on absorbing blood and proteins.
Lead researcher: Prof. Shachar
Richter
• Honeycomb Battery (2014) – A
startup company based on
3D concentric on-chip silicon
microbattery technology, enabling
fabrication of 10-30K microbattery
units in the perforated chip.
Lead researchers: Prof. Diana
Golodnitsky, Prof. Emanuel Peled
and Prof. Menachem Nathan
• StoreDot Ltd. (2013) is a leader
in the innovation of materials
and their device applications,
developing groundbreaking
technologies based on a
unique methodology for the
design, synthesis and tuning
of new organic compounds.
These proprietary compounds
dramatically improve the
performance of a range of devices,
including batteries, displays,
sensors and digital memory. Lead
researcher: Prof. Gil Rosenman
company developing novel hair
coloring using unique strongly
adhering coating beads. Lead
researcher: Prof. Amihay Freeman
• Savicell Diagnostics (2012) - A
cancer diagnostic kit. Lead
researcher: Prof. Fernando Patolsky
• Quiet Therapeutics (2010) - A
startup company developing a
drug delivery technology. Lead
researchers: Prof. Rimona Margalit
and Prof. Dan Peer
• Tracense Systems (2010) - A startup
company developing a nanotechbased “electronic nose” to sniff
out security threats like bombs,
biological warfare agents and
toxic liquids. Lead researcher: Prof.
Fernando Patolsky
License Agreements
• Aerie Pharmaceuticals (2015)
- First-in-class therapies for antibeta amyloid small molecules for
the treatment of patients with
glaucoma and dry AMD and other
eye diseases. Lead researcher: Prof.
Ehud Gazit
• Dexcel Pharma Technologies (2015)
– Parkinson’s disease therapy,
based on the identification of
new beta-synuclein recognition
modules. This disease-modifying
treatment may enable inhibition
of disease progression, in contrast
to current symptomatic therapy
that does not arrest disease
progression. Lead researcher: Prof.
Ehud Gazit
• Civan Advanced Technology
(2015) - Development of a highpower laser based on the coherent
combination of fibers. Lead
researcher: Prof. Shlomo Ruschin
• Variantyx Ltd. (2014) – Clinical
grade, end-to-end genome
analysis services for physicians
and hospitals worldwide. Lead
researcher: Dr. Noam Shomron
• Hall Effect Multi-bit magnetic
random access memory (MRAM),
signed with Samsung Global
MRAM Innovation. Lead researcher:
Prof. Alexander Gerber (2014)
• PEG-dendrimer hybrids as novel
nano-carriers for pesticides
delivery, signed with Makhteshim
Chemical Works LTD. Lead
researcher: Dr. Roey J. Amir (2014)
• A novel approach to fuel marking,
signed with Eurocontrol Technics
Group Inc. (TSX Venture: EUO).
Lead researcher: Prof. Fernando
Patolsky (2014)
• Discrimination of white blood cell
populations with label-free digital
holographic microscopy, signed
with Siemens AG. Lead researcher:
Dr. Natan Tzvi-Shaked (2014)
• Optical interferometry microscopy
system and algorithms for nondestructive optical inspection,
signed with Applied Materials Israel
Ltd. Lead researcher: Dr. Natan TzviShaked (2014)
• Electrochemical deposition of
hydroxyapatite on dental implants,
signed with SGS International Ltd.
Lead researcher: Prof. Noam Eliaz
(2014)
• Nonpharma, polypeptide
nanostructures for use in products
of field effect transistors, signed
with The Technical University of
Denmark (DTU). Lead researcher:
Prof. Ehud Gazit (2013)
SPINOFFS
• Fluorescent nanomaterial for
• New hair coloring products based
product authenticity verification,
signed with Tata Steel Ltd. Lead
researcher: Prof. Gil Markovich
(2013)
• Phenylalanine fibrils antibodies
related to PKU, signed with EMD
Millipore Corporation. Lead
researcher: Prof. Ehud Gazit. (2013)
• New drugs to treat schizophrenia
and bipolar disorder, signed with
Mental‐Heal Ltd. Lead researchers:
Prof. Moshe Portnoy, Prof. Avi
Weizman and Dr. Irit Gilad (2013)
• Targeted cancer therapy based
on miR‐21, signed with Tickro
Technologies. Lead researchers:
Dr. Ella Sklan and Dr. Rina RosinArbesfeld (2013)
on unique coating beads which
strongly adhere to the hair surface,
signed with NoAm ColorTech
Ltd. Lead researcher: Prof. Amihay
Freeman (2013)
• Improving laser efficiency in OPO
laser systems for airborne defense
systems against heat-seeking
missiles, signed with Elbit SystemsElop. Lead researcher: Prof. Ady Arie
(2012)
• Coral-derived collagen for
tissue engineering, signed with
ExceeMatrix Ltd. Lead researcher:
Prof. Dafna Benayahu (2012)
• Drug-eluting composite structures,
signed with Active Healing Bio
Medical Ltd. Lead researcher: Prof.
Meital Zilberman (2012)
• Transparent conductive coating
with nanowires for flat panel
applications, signed with Nepes.
Lead researcher: Prof. Gil Markovich
(2012)
• A new drug for Parkinson’s disease,
signed with Bioline Rx. Lead
researcher: Prof. Ehud Gazit (2012)
• Peptide nanotube electrodes for
energy storage applications, signed
with an Israeli defense industry
company. Lead researchers: Prof.
Ehud Gazit and Prof. Gil Rosenman
(2010)
• Transparent conducting nanowires,
signed with an Israeli startup in
the field of photovoltaic coatings.
Lead researcher: Prof. Gil Markovich
(2009)
Staff
Core Staff
Prof. Yael Hanein
Director
Mr. Zvi Kopolovitch
Managing Director
Ms. Michal Shenhar
Administrative Director
Dr. Yigal Lilach Electron & Ion Beam Lithography & Microscopy Manager
Dr. Artium Khatchatouriants
Bio-AFM Laboratory Manager
Mr. Valery Gerber Process Engineer & Business Development
Dr. David Schreiber
Process Engineer
Dr. Netta Handler
Process Engineer
Mr. Gidon Jacob
Equipment Engineer
Mr. Yoav Benjamin
Equipment Engineer
Mr. Yuval Kupitz
Head of International Collaborations
Dr. Inbal Halevi FTA Manager
Ms. Noa Shafir Secretary
Core Members
Prof. Shachar Richter
Department of Materials Science and Engineering
Prof. Yael Hanein
School of Electrical Engineering
Prof. Fernando Patolsky
School of Chemistry
Prof. Koby Scheuer
Prof. Dan Peer
Faculty of Life Sciences
Prof. Roy Beck-Barkai
School of Physics & Astronomy
Scientific Committee
Prof. Ori Cheshnovsky School of Chemistry (Chairperson)
Prof. Rimona Margalit
Prof. Yoram Dagan
School of Physics & Astronomy
Prof. Yael Hanein
School of Electrical Engineering (Director)
Prof. Fernando Patolsky
School of Chemistry
Prof. Dan Peer
Prof. Jacob Scheuer
Dr. Inna Slutsky
Faculty of Medicine
Prof. Amit Kohn
Department of Materials Science and Engineering
Acknowledgments
• The Chaoul Center for Nanoscale Materials and Systems
• The Marian Gertner Institute for Medical Nanosystems
• Vinci Technologies (Mr. Renaud Presberg)
• The Delaudaio Family (Argentina)
• Ms. Sara Weis (Australia)
• Mr. Shlomo Eliahu (Israel)
• Mr. Eli Horn (Brazil)
• Mr. Robert Goldberg (USA)
• James Russell DeLeon – The Center for Nanostructuring
• The Jack H. Skirball National Center for Biomedical Nanoscience
• Nanotechnology Research Fund in Cooperation with Clal Biotechnical Industries
• The Ilona Rich Institute for Nanoscale Bioscience and Biotechnologyv
• The Dr. Teodoro Jack and Dorothea Krauthamer Laboratory for Scanning Electron Microscopy
• A.V.B.A. Students Laboratory for Electron Beam Lithography
• Infrastructure Equipment for Nanotechnology Research - Wolfson Family Charitable Trust (UK)
• The Raymond and Beverly Sackler Chair in Clusters and Nanoparticles
• The Edouard Seroussi Chair for Protein Nanobiotechnology
• The Herman and Kurt Lion Chair in Nanosciences and Nanotechnologies
• The Bernard L. Schwartz Chair and Program in Nanoscale Information Technology
• Support for Nanotechnology Research donated by The Gilman Foundation
• Walanpatrias Stiftung
• Pa’amei Tikva Nanotechnology Research Fund (Israel 2004) LTD
Scholarships
• Mr. Ezekiel Solomon (Australia)
• The Cohen Family Doctoral Fellowship for the Study of Nanoscience
• The Buchman Heyman Foundation
• The Herb and Sharon Glaser Foundation
• Mr. Brian Lieber (UK)
• Mr. Doron Kochavi (Israel)
Since 2007 the Center is generously supported by the Israel Nanotechnology National
Initiative (INNI) program, founded by TELEM (2007-2016)

scientific report 2015–2016 - Tel Aviv University Center for

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