Tuesday

Tuesday
May 3, 2016
199
200
200
326 General
Business Meeting
Tahoma 5,
TCC
309 Bipolar, Horizontal and Amacrine
cells [VN] #2829-2835
356 Integration in stem cell therapy –a
challenge and a hope for vision — SIG [NT,
AP, CL, RE, RC, VN]
336 Corneal Wound Repair and
Regenerative Medicine [CO] #3475-3481
308 THC, Telehealth and Trichiasis: A CL
potpourri [CL] #2822-2828
Tahoma 3,
TCC
337 Next generation sequencing: What’s
next? — Minisymposium [BI] #3482-3488
355 Applications of Genome Editing
Techniques in Biology of Anterior Segment —
SIG [AP, BI, CL, CO, GL, LE, GEN]
335 Photoreceptor degeneration, rescue
and live imaging [RC] #3468-3474
307 Stem Cells: Disease Models and
Therapeutics I [RC] #2815-2821
Tahoma 1/2,
TCC
Tahoma 4,
TCC
354 Big Data and Data Visualization - Novel
insights into retina disorders, glaucoma and
cataract — SIG [GL, RE]
334 Eye and pregnancy —
Minisymposium [IM, CL, CO, LE, PH, RE]
#3463-3467
Skagit 4/5,
TCC
618-620
349 MOI Group - Intra-operative OCT [MOI]
333 Drug Delivery [PH] #3456-3462
306 Cornea Endothelium [CO] #28082814
615-617
Minisymposium [VI, CL, EY, RE] 3450-3455
332 Optics of the eye and vision —
305 AO Imaging [VI] #2801-2807
611/612
351 Identifying Your Career Options using
MyIDP, ScienceCareers.org, LinkedIn & More
352 NIH-CSR Workshop on the Review of
Grant Applications
331 Lens Development [LE] #3443-3449
609
608
330 Dry Eye: Clinical and Epidemiology
[CO] #3436-3442
350 Making a difference — how you can
advocate your research to patients and the
public using social media as an effective
outreach tool
304 Ocular Surface Neovascularization,
Innervation, and Immunology [CO]
#2794-2800
353 Managing Patients with Diabetic Macular
Edema, Neovascular AMD, and Retinal Vein
Occlusion: How to Best Utilize Data from
Clinical Trials — SIG [RE, CL, IM, PH, VN]
358 MIT Outstanding Poster Award Competition
1–2:30pm
Cross-Sectional Group/Workshops/SIGs
606/607
329 Retinal Vascular Diseases [RE]
#3429-3435
328 OCT Angiography 2 [RE] #3422-3428
327 Glaucoma Visual Fields and Visual
Function [GL] #3415-3421
11am–12:45pm
Papers/Minisymposia
357 Eighth Annual Women in Eye and Vision
Research (WEAVR) Luncheon
303 Imaging the ocular circulation Minisymposium [RE] #2785-2793
6C
10:15–10:55am
6E
302 Glaucoma Neuroprotection [GL]
#2778-2784
301 Fluids inside and around the eyes
in ocular health and pathologies —
Minisymposium [AP, GL, NT, PH, RE]
#2772-2777
8:30–10:15am
Papers/Minisymposia
6B
6A
2AB
Room
Tuesday, May 3
373 Connecting the retina to the brain:
The mouse — Minisymposium [VN]
#3848-3852
372 Photoreceptor degeneration and
phototransduction [BI] #3841-3847
371 A wide view on Glaucoma
epidemiology [CL] #3834-3840
370 Retinal Development II: Cell
differentiation and determination [RC]
#3827-3833
369 Microbiology / Immunology /
Translational / Innate immunity [IM]
#3820-3826
368 Amblyopia [EY] #3813-3819
367 Trabecular Meshwork and Aqueous
Humor Dynamics [GL] #3806-3812
366 Optical imaging, adaptive optics and
vision [VI] #3799-3805
365 Lens fiber cell biology [LE] #3792-3798
364 Novel signaling mechanisms in
refractive development [AP] #3785-3791
363 Corneal cell and molecular biology
and imaging [CO] #3778-3784
362 AMD Imaging [RE] #3771-3777
361 Retinal Stem Cells and
Transplantation [RE] #3766-3770
360 Glaucoma Imaging I [GL]
#3759-3765
3:45 –5:30pm
Papers/Minisymposia
1 – 2:30pm
Room 2AB
MIT Outstanding
Poster Award
Competition
5:45 – 7pm
6B
ARVO/
Champalimaud
Award Lecture
1:00 – 2:30pm
Room 6E
(tickets required)
8th Annual
WEAVR
Luncheon
on Skybridgel
9am – 4pm
NAEVR Central
9am – 5:30pm
Exhibit Hall
opens 7am
Exhibit hours
Atrium Lobby
7am – 6pm
ARVO Annual
Meeting
Registration
386 ARVO/Champalimaud
Award Lecture
5:45–7pm
201
Glaucoma Clinical studies / Pharmacology [GL, RE]
Trauma: Effects and Outcomes [CL]
Lens development and fiber cell biology [LE]
Amblyopia [EY]
IOL Optical Properties and Presbyopia Correction [VI]
Retinal Genetics [GEN]
Molecular and biochemical mechanisms of retinal disease [BI]
Diabetic Retinopathy [RC]
Diabetic retinopathy and steroids [RE ]
Inflammation / Infection/ Imaging /
Non infectious Uveitis [IM, GL]
AMD and anti-VEGF Therapy 2 [RE ]
Clinical Imaging - Miscellaneous [MOI, LE, LV]
314
315
316
317
318
319
320
321
322
323
324
325
Corneal Neovascularization and Conjunctival
Cell Biology and Surgery [CO, RC]
Glaucoma Biomechanics [GL]
Ganglion Cells and Beyond [VN, LV]
Clinical electrophysiology [VN]
Genes and proteins in myopia: Humans and
Animal models [AP]
Retinoids and carotenoids: Visual cycle and
macular pigment [BI]
Angiogenesis: Molecular and Cellular Effectors I [RC]
What is New in Retinoblastoma? [AP]
AMD Clinical Research 2 [RE ]
Retinal Prosthesis and Stem Cells [RE ]
Functional Imaging [MOI, AP]
338
339
340
341
342
343
344
345
346
347
348
Session
Title
Glaucoma Blood Flow [GL]
313
Session
Number
Glaucoma Surgery I [GL]
312
11am–12:45pm
Keratoconus and Collagen Crosslinking [CO]
8:30–10:15am
Dry Eye II [CO]
Session
Title
Posters
311
n
310
Session
Number
Tuesday, May 3
3743 - 3758
3713 - 3742
3688 - 3712
3659 - 3687
3629 - 3658
3617 - 3628
3606 - 3616a
3588 - 3605
3574 - 3587
3540 - 3573
3489 - 3539
Program
Number
3371 - 3414
3321 - 3370
3287 - 3320
3239 - 3286a
3201 - 3238
3171 - 3200
3132 - 3170
3102 - 3131
3078 - 3101
3059 - 3077
3046 - 3058
3003 - 3045
2957 - 3002
2923 - 2956
2883 - 2922
2836 - 2882
Program
Number
D0235 - D0250
D0174 - D0203
D0099 - D0123
C0133 - C0161
B0301 - B0330
B0220 - B0231
B0153 - B0163a
B0028 - B0045
B0014 - B0027
A0238 - A0271
A0092 - A0142
Board
Number
D0308 - D0351
D0124 - D0173
D0029 - D0062
C0039 - C0086a
C0001 - C0038
B0271 - B0300
B0232 - B0270
B0107 - B0136
B0065 - B0088
B0046 - B0064
B0001 - B0013
A0352 - A0394
A0306 - A0351
A0272 - A0305
A0143 - A0182
A0045 - A0091
Board
Number
Glaucoma Visual Fields and Electrophysiology [GL]
Accommodation [VI]
Clinical Aspects of Refractive Error [CL]
Ocular pharmacological and biological
applications of nanotechnology [NT]
Drug Delivery [PH, RE, LV, VN, RC, MOI, EY]
Vitreoretinal Interface Disase [RE ]
Melanoma and Lymphoma: from Models to Man [AP]
Uveitis Epidemiology [IM, CL]
Macular Edema Clinical and Translational [RE ]
Müller Cells and Astrocytes In Development
and Disease [RC, GL, LE, NT]
Clinical and Other Applications of OCT [MOI, AP]
376
377
378
379
380
381
382
383
384
385
4216 - 4272
4185 - 4215
4149 - 4184
4121 - 4148
4088 - 4120
4042 - 4087
3997 - 4041
3986 - 3996
3970 - 3985
3952 - 3969
3897 - 3951
3853 - 3896
Program
Number
D0251 - D0307
D0204 - D0234
D0063 - D0098
D0001 - D0028
C0162 - C0194
C0087 - C0132
B0175 - B0219
B0164 - B0174
B0137 - B0152
B0089 - B0106
A0183 - A0237
A0001 - A0044
Board
Number
2:45–3:45pm: All Posters and Networking — authors will be present at poster
boards
1–2:30pm: MIT Outstanding Poster Award Competition
(Room 2AB)
Poster board numbers correspond to poster location in Exhibit Hall
A = Poster Area A , B = Poster Area B , C = Poster Area C and D =Poster Area D
Ocular Surface Health and Disease [CO]
375
Session
Title
374
Session
Number
3:45–5:30pm
NOTES
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202
Tuesday – Papers/Minisymposium – 2772 – 2789
Room 6A
Room 6B
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Anatomy and Pathology/Oncology / Glaucoma /
Nanotechnology and Regenerative Medicine /
Physiology/Pharmacology / Retina
Glaucoma
301 Fluids inside and around the eyes
in ocular health and pathologies Minisymposium
Fluid dynamics inside and around the eye affect
multiple aspects of eye health and disease. This
symposium will share how fluids maintain a
healthy eye environment, how their disruption can
contribute to disease, and how we can harness their
power for therapeutics.
Moderators: Yeni H. Yucel and Shahar Frenkel
2773 — 8:47 Fluid shifts in microgravity: The
visual impairment and intracranial pressure
syndrome in U.S. astronauts. Christian Otto.
Division of Space Life Sciences, Universities
Space Research Association, Houston, TX; Human
Research Program, NASA Johnson Space Center,
Houston, TX
2774 — 9:04 What has genomics taught us
about aqueous humor dynamics, cerebral spinal
fluid dynamics and ocular perfusion pressure?
Louis R. Pasquale. Harvard Medical School,
Boston, MA *CR
2775 — 9:21 Pharmacokinetics of
Chemotherapy Delivery for Retinoblastoma.
David H. Abramson. Memorial Sloan Kettering
Cancer, New York, NY; Ophthalmology, Weill
Cornell Medical School, New York, NY
2776 — 9:38 Drug delivery for ocular surface
malignancies. Jacob Pe’er. Hadassah-Hebrew Univ
Med Ctr, Jerusalem, Israel
2777 — 9:55 Fluidics: Drivers for selective
drug delivery into the eye. Uday B. Kompella.
University of Colorado Denver, Aurora, CO *CR
Moderators: Adriana Di Polo and Keith R. Martin
2778 — 8:30 The yin and yang of the
complement cascade in glaucoma - the
importance of timing and location. Gareth R.
Howell1, P. Williams1, J. Harder1, J. Tribble2, K.
Pepper1, S. Cross2, P. Morgan2, J. E. Morgan2, S. W.
John1. 1The Jackson Laboratory, Bar Harbor, ME;
2
Cardiff University, Cardiff, United Kingdom
2779 — 8:45 Soluble Fas ligand provides
long-term protection in a chronic mouse model
of glaucoma by inhibiting glial activation,
inflammation, and apoptosis. Meredith S.
Gregory-Ksander1, 2, F. Fei1, 2, A. MarshakRothstein3, B. Ksander1, 2, A. Krishnan1, 2. 1Schepens
Eye Research Institute, Mass Eye & Ear Infirmary,
Boston, MA; 2Ophthalmology, Harvard Medical
School, Boston, MA; 3Medicine, University of
Massachusetts Medical School, Worcester, MA
2780 — 9:00 Müller glial cell-specific GDNF
expression promotes retinal ganglion cell
survival in DBA/2J mice. Anna M. Demetriades1,
C. Pan1, L. C. Byrne2, E. Ahmed1, J. Harder3, S. W.
John3, J. G. Flannery2. 1Weill Cornell Medicine,
New York, NY; 2University of California, Berkeley,
Berkeley, CA; 3The Jackson Laboratory, Bar
Harbor, ME
2781 — 9:15 Citicoline preserves optic
nerve integrity and visuomotor function
following chronic intraocular pressure
elevation. Yolandi van der Merwe1, 2, X. Yang1, 3,
L. C. Ho1, 4, Y. Yu5, Y. Chau5, C. K. Leung6, 7, I.
P. Conner2, 3, M. B. Steketee3, G. Wollstein2, 3, J.
S. Schuman2, 3, K. C. Chan1, 3. 1Neuroimaging
Laboratory, University of Pittsburgh, Pittsburgh,
PA; 2Department of Bioengineering, University
of Pittsburgh, Pittsburgh, PA; 3UPMC Eye
Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh,
Pittsburgh, PA; 4Department of Electrical and
Electronic Engineering, University of Hong Kong,
Hong Kong, China; 5Division of Biomedical
Engineering, Hong Kong University of Science
and Technology, Hong Kong, China; 6University
Eye Center, Hong Kong Eye Hospital, Hong Kong,
China; 7Department of Ophthalmology and Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, China *CR
2782 — 9:30 AMP-activated protein kinase,
a conserved energy biosensor, signals early
neuronal pathogenesis in glaucoma through
inhibition of the mammalian target of
rapamycin. Nicolas A. Belforte, J. L. Cueva Vargas,
A. Di Polo. Neuroscience, University of Montreal
Hospital Research Center, Montreal, QC, Canada
2784 — 10:00 Ocular hypertension induces
early mitochondrial alterations in retinal
endothelial cells in a murine glaucoma model.
Yoko Ito2, A. M. Wilson1, C. Vande Velde2, P.
Sapieha1, A. Di Polo2.1Ophthalmology and Visual
Science, University of Montreal, Montreal, QC,
Canada; 2Neuroscience, CRCHUM (University of
Montreal), Montreal, QC, Canada
Room 6C
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Retina
303 Imaging the ocular circulation Minisymposium
New technologies for imaging the ocular circulation
are poised to revolutionize are approach to studying
these disorders and managing patients. This
symposium provides a comprehensive review of the
most promising new approaches for assessing the
ocular circulation with a particular focus on OCT
angiography.
Moderators: Philip J. Rosenfeld and
Richard F. Spaide
2785 — 8:30 Adaptive Optics Scanning Light
Ophthalmoscopy Microangiography. Richard
B. Rosen. Ophthalmology, New York Eye &
Ear Infirmary of Mount Sinai, New York, NY;
Ophthalmology, Icahn School of Medicine at Mount
Sinai, New York, NY *CR
2786 — 8:40 Understanding of inflammatory
and non-inflammatory choroidal thickening
using laser speckle flowgraphy. Susumu Ishida.
Hokkaido Univ Grad Sch of Med, Sapporo, Japan
2787 — 8:50 En Face OCT Measurement of
the Ocular Circulation. David Huang. Oregon
Health & Science Univ, Portland, OR *CR
2788 — 9:00 OCTA - overview of the
technology and outlook for the future. James G.
Fujimoto. Electrical Engineering and Computer
Science, Massachusetts Insttitute of Technology,
Cambridge, MA *CR
2789 — 9:10 Quantitative flow assessments
with OCT Angiography. Johannes F. De
Boer. Physics and Astronomy, VU Amsterdam,
Amsterdam, Netherlands *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
203
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2772 — 8:30 Aqueous humor dynamics in
health and disease. Carol B. Toris. Case Western
Reserve University, Cleveland, OH; University
of Nebraska Medical Center, Ophthalmology and
Visual Sciences, Omaha, NE
302 Glaucoma Neuroprotection
2783 — 9:45 Improved neuronal survival
after intravitreal injection of an α-synuclein
antibody in a glaucoma animal model. Julia
Teister, F. Anders, V. Prokosch, S. Beck, S. Funke,
C. Manicam, A. Gericke, N. Pfeiffer, F. H. Grus.
Ophthalmology, University Medical Center, Mainz,
Mainz, Germany
2790 – 2809 – Tuesday – Papers/Minisymposium
2790 — 9:20 Noninvasive visualization and
analysis of the human parafoveal capillary
network using swept source OCT optical
microangiography. Srinivas R. Sadda. University
of California - Los Angeles, Los Angeles, CA;
Doheny Image Reading Center, Doheny Eye
Institute, Los Angeles, CA *CR
2791 — 9:30 OCTA in retinal vascular diseases.
Nadia K. Waheed. New England Eye Center/Tufts
University, Boston, MA *CR
2792 — 9:40 Imaging Choroidal
Neovascularization with OCTA. David
Sarraf. Stein Eye Institute, Los Angeles, CA;
Ophthalmology, UCLA, Los Angeles, CA *CR
2793 — 9:50 OCTA in atrophic maculopathies.
Giovanni Staurenghi. University of Milan, Milano,
Italy *CR
— 10:00 Discussion
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
Room 606/607
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Cornea
304 Ocular Surface Neovascularization,
Innervation, and Immunology
Moderators: Pedram Hamrah and
Mark Rosenblatt
2794 — 8:30 Corneal Sub-Basal Nerve Plexus
Density in Parkinson’s Disease. Hannah Kersten1,
S. Misra1, R. H. Roxburgh2, H. V. Danesh-Meyer1,
C. N. McGhee1. 1Ophthalmology, University of
Auckland, Auckland, New Zealand; 2Neurology,
Auckland City Hospital, Auckland, New Zealand
2795 — 8:45 Reversibility of diet-induced
corneal degeneration in a mouse model. Aubrey
Hargrave1, M. Chintalapati2, P. Mehta2, P. Landry1,
S. Magadi1, C. W. Smith2, A. R. Burns1. 1College of
Optometry, University of Houston, Houston, TX;
2
Pediatric-Children’s Nutrition Research Center,
Baylor College of Medicine, Houston, TX
2796 — 9:00 Relationships between
central corneal nerve parameters and tear
neuropeptides. Fiona Stapleton1, C. Chao1, 2, I.
Jalbert1, P. S. Mandathara1, S. Kolanu1, M. D.
Willcox1, M. Markoulli1, J. You3, 1, J. Kim1, E. Lum1,
B. Golebiowski1. 1Optometry and Vision Science,
University of New South Wales, Kensington
Sydney, NSW, Australia; 2College of Optometry,
State University of New York, New York, NY;
3
Save Sight Institute, Sydney University, Sydney,
NSW, Australia
2797 — 9:15 Pathological lymphangiogenesis
is regulated by galectin-8-dependent crosstalk
among VEGF-C, podoplanin and integrin
pathways. Wei-Sheng Chen, Z. Cao, S. Sugaya,
M. J. Lopez, V. Sendra, N. V. Laver, P. Hamrah,
N. A. Panjwani. Ophthalmology, Tufts University,
Boston, MA
2798 — 9:30 Cholinergic regulation of
dendritic cell uptake and immune response to
topically applied antigens to the conjunctiva.
Stephen C. Pflugfelder, C. S. De Paiva, T. G.
Coursey, F. L. Barbosa. Ophthalmology, Baylor
College of Medicine, Houston, TX
2799 — 9:45 The ocular surface phenotype of
Spdef -/- mice: Accumulation of debris but lack
of infection upon challenge with Pseudomonas
aeruginosa. Ilene K. Gipson, S. Spurr-Michaud, A.
Tisdale, B. B. Menon. Ophthalmology, Schepens
Eye Research Inst/MEEI, Boston, MA
2800 — 10:00 Infrared thermography used
to provide evidence for the pre-ocular tear film
being a fluid shell. Thomas J. Millar, B. Schuett.
School of Science and Health, Western Sydney
University, Penrith, NSW, Australia
Room 611/612
Tuesday, May 03, 2016 8:30 AM-10:15 AM
2805 — 9:30 Individual inner retinal neurons
imaged in the living eye of monkey and human.
Ethan A. Rossi1, R. Sharma1, C. Granger1, 2,
C. Schwarz1, Q. Yang1, J. J. Hunter1, 3, D. R.
Williams1, 2. 1Center for Visual Science, University
of Rochester, Rochester, NY; 2The Institute of
Optics, University of Rochester, Rochester, NY;
3
Ophthalmology, Flaum Eye Institute, Rochester,
NY *CR
2806 — 9:45 Label Free Imaging of Ganglion
Cells in the Living Mouse Eye. Jesse B.
Schallek1, 2, A. Joseph3, 2, A. Guevara-Torres3, 2.
1
Flaum Eye Institute, University of Rochester,
Rochester, NY; 2Center for Visual Science,
University of Rochester, Rochester, NY; 3The
Institute of Optics, University of Rochester,
Rochester, NY *CR
2807 — 10:00 Measuring organelle motility
in RPE cells in the living human retina. Zhuolin
Liu, K. Kurokawa, O. P. Kocaoglu, F. Zhang, D.
T. Miller. optometry school, Indiana University,
Bloomington, IN *CR
Visual Psychophysics/Physiological Optics
305 AO Imaging
Room 615/617
Moderators: Nicole M. Putnam and
Donald T. Miller
2801 — 8:30 Aging, age-related macular
degeneration, and the neural economy
hypothesis. Ann E. Elsner, J. A. Papay, K. D.
Johnston, B. King, S. L. Polster, T. Y. Chui,
S. A. Burns. Optometry, Indiana University,
Bloomington, IN
2802 — 8:45 Modeling the Relationship
Between Foveal Cone Density and Outer
Segment Length. Melissa A. Wilk1, R. F.
Cooper2, 4, B. M. Wilk3, C. S. Langlo1, J. Carroll1, 3.
1
Cell Biology, Neurobiology, & Anatomy, Medical
College of Wisconsin, Hartford, WI; 2Psychology,
University of Pennsylvania, Philadelphia, PA;
3
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 4Ophthalmology, University of
Pennsylvania, Philadelphia, PA
2803 — 9:00 Contiguous mapping of retinal
pigment epithelium (RPE) cell morphometry
across the horizontal meridian of the living
human eye. Charles Granger1, 2, H. Song2, Q.
Yang2, K. Saito3, K. Nozato3, D. R. Williams1, 2, M.
M. Chung2, 4, E. A. Rossi2. 1The Institute of Optics,
University of Rochester, Rochester, NY; 2Center for
Visual Science, University of Rochester, Rochester,
NY; 3Canon U.S.A. Inc., Melville, NY;4Flaum Eye
Institute, University of Rochester, Rochester, NY
*CR
2804 — 9:15 Imaging Photoreceptor Shedding
in the Living Human Eye. Omer P. Kocaoglu,
Z. Liu, K. Kurokawa, D. T. Miller. School of
Optometry, Indiana University, Bloomington, IN
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Cornea
306 Cornea Endothelium
Moderators: Ula V. Jurkunas and Noriko Koizumi
2808 — 8:30 New evidence suggesting that
the central endothelium presents features of
peripheral endothelium in Fuchs endothelial
corneal dystrophy. Zhiguo HE1, P. Gain1, A. S.
Jun2, F. Forest1, 3, L. Kallay2, J. Dumollard3, F.
Bergandi4, M. Peoc’h3, G. Thuret1, 5. 1Corneal Graft
Biology, Engineering and Imaging Laboratory,
EA2521, Jean Monnet University, Saint Etienne,
France; 2Cornea, Cataract, and Refractive Surgery
Services, Wilmer Eye Institute/Johns Hopkins
Medical Institutions, Baltimore, MD; 3Department
of Pathology, University Hospital of Saint-Etienne,
Saint Etienne, France; 4Department of Anatomy,
Jean Monnet University, Saint Etienne, France;
5
Institut Universitaire de France, Paris, France
2809 — 8:45 Trinucleotide repeat expansion
and TCF4 gene expression in Fuchs endothelial
corneal dystrophy. Keisuke Ogata1, N. Okumura1,
R. Hayashi1, M. Nakahara1, M. Nakano2, K.
Tashiro2, S. Kinoshita3, U. Schlötzer-Schrehardt4,
T. Tourtas4, F. E. Kruse4, N. Koizumi1. 1Department
of Biomedical Engineering, Faculty of Life and
Medical Sciences, Doshisha University, Kyotanabe,
Japan; 2Department of Genomic Medical Sciences,
Kyoto Prefectural University of Medicine, Kyoto,
Japan; 3Department of Frontier Medical Science and
Technology for Ophthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan; 4Department
of Ophthalmology, University of ErlangenNürnberg, Erlangen-Nuremberg, Germany
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
204
Tuesday – Papers/Minisymposium – 2810 – 2824
2810 — 9:00 UV-A Irradiation Induced
Mouse Model of Fuchs Endothelial Corneal
Dystrophy. Cailing Liu1, T. Miyai1, D. Vojnovic1,
I. E. Kochevar2, U. V. Jurkunas1. 1Schepens Eye
Research Institute, Massachusetts Eye and Ear,
Department of Ophthalmology, Harvard Medical
School, Boston, MA; 2Wellman Center for
Photomedicine, Massachusetts General Hospital,
Boston, MA
2811 — 9:15 Unfolded protein accumulation
induced endoplasmic reticulum stress of corneal
endothelial cells in Fuchs endothelial corneal
dystrophy. Naoki Okumura1, K. Hashimoto1, M.
Kitahara1, M. Nakahara1, S. Kinoshita2, T. Tourtas3,
U. Schlötzer-Schrehardt3, F. E. Kruse3, N. Koizumi1.
1
Doshisha University, Kyotanabe, Japan; 2Kyoto
Prefectural University of Medicine, Kyoto, Japan;
3
University of Erlangen-Nürnberg, Erlangen,
Germany *CR
2813 — 9:45 Functional gene transfer for
antiapoptotic therapy of corneal endothelial
cells - a magnetofection approach. Marta
Czugala3, O. Mykhaylyk1, A. K. Gruenert3, F. E.
Kruse3, S. Wesselborg2, C. Plank1, T. A. Fuchsluger3.
1
Institute of Experimental Oncology, Technical
University Munich, Munich, Germany; 2Institute
of Molecular Medicine I, University Hospital
Düsseldorf, Düsseldorf, Germany; 3Department of
Ophthalmology, University Erlangen-Nurnberg,
Erlangen, Germany
2814 — 10:00 Corneal Endothelial Pump Is
Dependent on Buffering Lactic Acid Efflux.
Joseph A. Bonanno, E. Kim, S. Li. School of
Optometry, Indiana University, Bloomington, IN
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Retinal Cell Biology
307 Stem Cells: Disease Models and
Therapeutics I
Moderators: Valeria Canto Soler and
David M. Gamm
2815 — 8:30 Endogenous expression of
mutant BEST1 results in decreased Cl- and
Ca2+ conductance in human retinal pigment
epithelium. Michael D. O’Connor, M. Mangala, M.
Cameron, J. Morley. School of Medicine, Western
Sydney University, Penrith, NSW, Australia
2816 — 8:45 Human embryonic stem
cell-derived retinal pigment epithelial cells
functionally integrate and rescue photoreceptors
in a large-eyed model of geographic atrophy.
Sandra Petrus-Reurer1, 2, A. Plaza Reyes2, L.
Antonsson2, S. Stenfelt2, H. Bartuma1, S. Panula2,
H. Andre1, O. Hovatta2, F. Lanner2, A. P. Kvanta1.
1
Clinical Neuroscience, Section for Ophtalmology
and Vision, Karolinska Institutet, St. Erik Eye
Hospital, Stockholm, Sweden; 2Department of
Clinical Sciences, Intervention and Technology,
Karolinska Insitutet, Stockholm, Sweden
2817 — 9:00 Exogenous factors induce rod
and cone photoreceptor-specific progenitors
from adult mouse retinal stem cells. Brian G.
Ballios1, S. Khalili2, K. Grise2, L. Donaldson3,
G. Bernier4, M. Shoichet5, V. Wallace1, 6, D. van
der Kooy2. 1Department of Ophthalmology and
Vision Sciences, University of Toronto, Toronto,
ON, Canada; 2Molecular Genetics, University
of Toronto, Toronto, ON, Canada; 3Division of
Ophthalmology, McMaster University, Hamilton,
ON, Canada; 4Maisonneuve-Rosemont Hospital,
Centre de recherché, Université de Montréal,
Montréal, ON, Canada; 5Chemical Engineering and
Applied Chemistry, University of Toronto, Toronto,
ON, Canada; 6Vision Science Research Program,
Toronto Western Hospital, Toronto, ON, Canada
2818 — 9:15 Human Stem Cell Derived Retinal
Spheroids Characterized Non-Invasively for
Structure and Function by Multimodal Imaging.
Andrew Browne2, 1, C. Arnesano3, T. Kuu4, H.
Pollack4, R. Moats4, L. Thomas4, 2, J. Aparicio4,
S. Fraser3, 4, D. Cobrinik4, 2. 1Ophthalmology,
Cleveland Clinic, Cole Eye Institute, Cleveland,
OH; 2Ophthalmology, University of Southern
California, Los Angeles, CA; 3Department of
Biomedical Engineering, University of Southern
California, Los Angeles, CA; 4Children’s Hospital
of Los Angeles, Los Angeles, CA *CR
2819 — 9:30 Patient-specific iPSCs to
investigate pathophysiology and develop
treatments for RPGR-associated XLRP. Joseph
C. Giacalone, E. R. Burnight, T. P. Sharma, L. A.
Wiley, D. Ochoa, M. Collins, R. F. Mullins, B. A.
Tucker, E. M. Stone. Department of Ophthalmology
& Visual Sciences, Stephen A. Wynn Institute for
Vision Research, Carver College of Medicine,
University of Iowa, Iowa City, IA
2820 — 9:45 Gene-edited human induced
pluripotent stem cell derived 3D retinas for the
systematic optimization of retinal cup formation
by small molecule screening. Karl J. Wahlin2, S.
R. Sripathi1, K. Eldred3, J. Heng4, R. Johnston3, C.
Berlinicke1, D. J. Zack1. 1Ophthalmology, Johns
Hopkins School of Medicine, Baltimore, MD;
2
Ophthalmology, University of California, San
Diego, LaJolla, CA; 3Biology, Johns Hopkins
University, Baltimore, MD; 4Neuroscience, Johns
Hopkins School of Medicine, Baltimore, MD
2821 — 10:00 The effect of human embryonic
stem cell-derived extracellular vesicles (hESEVs)
on Müller cells and their potential use for retinal
regeneration. Debora B. Farber. Ophthalmology,
Stein Eye Institute/UCLA, Los Angeles, CA
Room Tahoma 3, TCC
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
308 THC, Telehealth and Trichiasis:
A CL potpourri
Moderators: Ingrid E. Zimmer-Galler and
Anand Vinekar
2822 — 8:30 Time requirements for
ophthalmology documentation with electronic
health records (EHRs): a time-motion and big
data study. Sarah Read-Brown, M. R. Hribar, J.
Wallace, L. G. Reznick, T. Yackel, M. F. Chiang.
Oregon Health & Science University, Portland, OR
*CR
2823 — 8:45 Teleophthalmology in a
Community Setting to Improve Eye Health
Among Latinos: A Paradigm Shift. Judy E. Kim1,
V. Medic1, A. Castro2, B. Rodriguez2, M. Bonet2,
M. DeNomie3, Z. Franco3, V. Bilen4, S. Cho1, S.
Ahamed4. 1Ophthalmology, Medical College of
Wisconsin, Milwaukee, WI; 2United Community
Center, Milwaukee, WI; 3Medical College of
Wisconsin, Milwaukee, WI; 4Marquette University,
Milwaukee, WI *CR
2824 — 9:00 Institutional Quality
Improvement for American Board of
Ophthalmology Maintenance of Certification.
Jennifer Weizer1, G. Greenberg2, V. Harrison2,
T. Blachley1, P. P. Lee1. 1Kellogg Eye Center,
University of Michigan, Ann Arbor, MI; 2University
of MIchigan, Ann Arbor, MI
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
205
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2812 — 9:30 Regulation of mitochondrial
respiration under cell culture stress in human
corneal endothelial cells. Shigeru Kinoshita2,
M. Ueno1, K. Asada2, M. Toda2, K. Nagata4, C.
Sotozono1, N. Kosaka3, T. Ochiya3, J. Hamuro1.
1
Ophthalmology, Kyoto Prefectural Univ of Med,
Kamigyo-Ku, Japan; 2Frontier Medical Science and
Technology for Ophthalmology, Kyoto Prefectural
Univ of Med, Kyoto, Japan; 3Division of Molecular
and Cellular Medicine, National Cancer Center
Research Institute, Tokyo, Japan; 4Toray Inc.,
Kamakura, Japan *CR
Room Tahoma 1/2, TCC
2825- – 2835 – Tuesday – Papers/Minisymposium
2825 — 9:15 Increased Incidence of Glaucoma
Diagnosis Following Passage of Medical
Marijuana Legislation. David S. Sanders2,
J. R. Ehrlich2, T. Blachley2, T. Cooney2, J. D.
Stein2, 1. 1Institute for Healthcare Policy and
Innovation, University of Michigan, Ann Arbor,
MI; 2Department of Ophthalmology and Visual
Sciences, University of Michigan, Ann Arbor, MI
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2826 — 9:30 Study of Knowledge, Attitudes
and Practices Related to Eye Diseases in the
Southern Indian States of Andhra Pradesh
and Telangana. Srinivasa Pallerla. School of
Optometry, university of New South Wales,
Hyderabad, India; Andhra Pradseh Right To Sight
Society, Hyderabad, India
2827 — 9:45 Surgical Simulation in Lowresource Settings Improves Intra-operative
Aspects of Trichiasis Surgery Training. Emily W.
Gower1, 2, A. B. Kello3, M. Kollmann4, J. Johnson5.
1
Public Health Sciences, Wake Forest School of
Medicine, Winston-Salem, NC; 2Ophthalmology,
Wake Forest School of Medicine, Winston Salem,
ND; 3Light For the World, Addis Ababa, Ethiopia;
4
CBM, Nairobi, Kenya; 5Wake Forest Innovations,
Winston-Salem, NC *CR
2828 — 10:00 Barriers to accessing surgery
for trachomatis trichiasis in Kongwa, Tanzania.
Ryan J. Bickley1, H. Mkocha2, B. E. Munoz1, S.
K. West1. 1Wilmer Eye Institute, Johns Hopkins
University School of Medicine, Baltimore, MD;
2
Kongwa Trachoma Project, Kongwa, United
Republic of Tanzania
Room Tahoma 5, TCC
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Visual Neuroscience
2831 — 9:00 Rod photoreceptors mediate
light-evoked activity of dopaminergic amacrine
cells across a wide range of light intensities.
Xiwu Zhao2, 1, S. Qiao2, 3, Y. Zhong3, K. Y. Wong1,
D. Zhang2.1Ophthalmology & Visual Sciences,
University of Michigan, Ann Arbor, MI; 2Eye
Research Institute, Oakland University, Rochester,
MI; 3Institute of Neurobiology, Fudan University,
Shanghai, China
2832 — 9:15 The absence of complexin 3
alters rod bipolar cell pathway function. Joshua
H. Singer1, L. S. Mortensen4, S. J. Park2, J. Ke1,
L. Zhang1, N. Brose4, J. Rhee4, J. B. Demb2, 3.
1
Biology, University of Maryland, College Park,
MD; 2Ophthalmology, Yale University, New
Haven, CT; 3Cellular and Molecular Physiology,
Yale University, New Haven, CT; 4AG Synapse
Physiology, Max-Planck-Institute of Experimental
Medicine, Göttingen, Germany
2833 — 9:30 Calcium signaling at Cx36 gap
junctions in the mouse retina. John O’Brien1,
Y. Lin1, W. Kothmann2, 3, K. B. Moore1, C. K.
Mitchell1, J. S. Diamond2. 1Ophthalmology, Univ of
Texas Houston Med Sch, Houston, TX; 2NINDS,
Bethesda, MD; 3American University,
Washington, DC
2834 — 9:45 Connectomics of irradianceencoding ON bipolar-cell inputs to ipRGCs.
Shai Sabbah1, M. Kim1, G. Manoff1, A. Bhatia-Lin1,
C. Papendorp1, K. Briggman2, D. M. Berson1.
1
Neuroscience, Brown University, Providence, RI;
2
National Institute for Neurological Disorders and
Stroke, National Institute of Health, Bethesda, MD
2835 — 10:00 Postnatal development of rod
bipolar cell dendrites in mouse retina. Ivan
Anastassov, F. Dunn. Ophthalmology, University of
California San Francisco, San Francisco, CA
309 Bipolar, Horizontal and
Amacrine cells
Moderators: Joshua H. Singer and
Catherine W. Morgans
2829 — 8:30 Quantification of the neurons
in the rod pathway of human retina. Sammy C.
Lee, R. J. Aghajani, P. R. Martin, U. Grunert. Save
Sight Institute - Department of Ophthalmology,
University of Sydney, Sydney, NSW, Australia
2830 — 8:45 Cone photoreceptors generate
inhibitory ON and OFF responses in
dopamingergic amacrine cells via distinct
OFF pathways. Sheng-Nan Qiao1, 2, Y. Zhong2,
D. Zhang1. 1Eye Research Institute, Oakland
University, Rochester, MI; 2Institute of
Neurobiology, Fudan University, Shanghai, China
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
206
Tuesday – Posters – 2836 – 2856
Exhibit/Poster Hall A0045-A0091
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Cornea
310 Dry Eye II
Moderator: Penny A. Asbell
2836 — A0045 Difference in tear meniscus
between conjunctivochalasis eyes and normal
eyes using anterior segment optical coherence
tomography. Kanako Kimura, Y. Takamura, M.
Gozawa, S. Yokota, T. Matsumura, M. Inatani.
Department of Ophthalmology, Faculty of Medical
Sciences, University of Fukui, Eiheiji, Yoshida,
Fukui, Japan
2837 — A0046 Objective Measurement of
Eyelash Parameters and their Relation to Dry
Eye Disease. John D. Rodriguez1, P. Corcoran1, E.
Angjeli1, C. Sundstrom1, G. W. Ousler2. 1Research
and Development, Ora Institute, Andover, MA; 2Dry
Eye, Ora, Inc., Andover, MA *CR
2839 — A0048 Sleep disturbance is associated
with dry eye syndrome in a rural population
in Korea : Study group for Environmental Eye
Disease (SEED). Hyungseon Yeom1, N. Kim2, J.
Song3, H. Lee4, H. Kim1. 1Department of Preventive
Medicine, Yonsei University School of Medicine,
Seoul, Korea (the Republic of); 2Department of
Public Health, Yonsei University Graduate School,
Seoul, Korea (the Republic of); 3Department of
Ophthalmology, Korea University College of
Medicine, Seoul, Korea (the Republic of); 4Institute
of Vision Research, Department of Ophthalmology,
Yonsei University College of Medicine, Seoul,
Korea (the Republic of)
2840 — A0049 Sleep disorders in dry eye
disease and allied irritating ocular diseases.
Masahiko Ayaki, M. Kawashima, K. Negishi,
T. Kishimoto, M. Mimura, K. Tsubota. Keio
University, Tokyo, Japan
2841 — A0050 Clinical characteristics of dry
eye patients with depression. Jelle Vehof1, 2, N.
Sillevis Smitt - Kamminga1, C. J. Hammond2.
1
Ophthalmology, University Medical Center
Groningen, Groningen, Netherlands; 2Twin research
and genetic epidemiology, King’s College London,
London, United Kingdom
2842 — A0051 Impact of Clinically Significant
Dry Eye on Self-Reported Driving Performance.
Priya M. Mathews, S. Karakus, P. Y. Ramulu, E.
K. Akpek. Wilmer Eye Institute, Johns Hopkins
University School of Medicine, Baltimore, MD *CR
2850 — A0059 Repeatability of Ocular Surface
Cooling Measurement. Wing Li1, 2, A. D. Graham2,
M. C. Lin1, 2. 1Vision Science Graduate Group,
University of California, Berkeley, CA; 2Clinical
Research Center, School of Optometry, University
of California, Berkeley, CA
2844 — A0053 Baseline Characteristics in the
Dry Eye Assessment and Management (DREAM)
Study. Milton M. Hom. Optometry, Private Practice,
Azusa, CA *CR, f
2852 — A0061 The Efficacy of Strip
Meniscometry and DEQS for Dry Eye Screening
during Medical Health checkups. Sho Ishikawa1,
N. Kato1, M. Takeuchi2. 1Ophthalmology,
Saitama Medical University, Moroyama, Japan;
2
Opthalmology, National Defence Medical Collage,
Tokorozawa, Japan
2845 — A0054 Objective Signs Correlate With
Subjective Symptoms in Dry Eye (DE). William
H. Ridder, E. Borsting, P. Yoshinaga, H. V. Ha, S.
Ridder. Southern California College of Optometry,
Marshall B. Ketchum University, Cypress, CA
2846 — A0055 Dermatological alterations in
Dry Eye Disease. Rossen M. Hazarbassanov1,
N. Queiroz-Hazarbassanov2, L. M. VasquezPinto3, M. M. Amaral3, J. P. Gomes1, M. Campos1.
1
Ophthalmology and Visual Sciences, Paulista
School of Medicine, Federal University of Sao
Paulo, Sao Paulo, Brazil; 2Pathology Department,
School of Veterinary Medicine and Animal
Sciences, Sao Paulo, Brazil; 3Natura Product
Technology, Cajamar, Brazil *CR
2847 — A0056 Correlation between
corneal changes by confocal microscopy and
symptomatology in patients with dry eye
syndromes. Tudor Tepelus1, G. B. Chiu2, J.
Huang1, P. Huang1, S. R. Sadda1, 3, O. L. Lee1, 3.
1
Ophthalmology, Doheny Image Readind Center/
Doheny Eye Institute, Los Angeles, CA; 2USC Eye
Institute, Keck School of Medicine, Los Angeles,
CA; 3UCLA Department of Ophthalmology/David
Geffen School of Medicine, Doheny Eye Center,
Los Angeles, CA *CR
2848 — A0057 Pain In Dry-Eye Patients
Without Corresponding Clinical Signs - A
Retrospective Analysis. Philipp Steven1, 4, T.
Schneider1, 4, I. Ramesh2, S. E. Siebelmann1, 4, U.
Gehlsen1, 4, J. Loeser3, D. Spohn3. 1Ophthalmology,
University of Cologne, Cologne, Germany;
2
Psychosomatic Medicine, University of Cologne,
Cologne, Germany; 3Anaesthesiology and Intensive
Care Medicine, University of Cologne, Cologne,
Germany;4Cluster of Excellence: Cellular Stress
Responses in Aging-associated Disease (CECAD),
University of Cologne, Cologne, Germany
2849 — A0058 Effects of experimental tear film
instability on sensory responses to corneal cold,
mechanical and chemical stimuli. Ping Situ1, T.
L. Simpson2, C. G. Begley1. 1School of Optometry,
Indiana University Bloomington, Bloomington,
IN; 2School of Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada
2851 — A0060 Ocular Surface Thermal
Imaging Pre- and Post-CAESM. Christian
Sundstrom1, K. J. Lane1, E. Angjeli1, P. Corcoran1,
G. W. Ousler2. 1Research and Development,
Ora,Inc., Andover, MA; 2Dry Eye, Ora, Inc.,
Andover, MA *CR
2853 — A0062 Identification of dry eye
subtypes by tear interferometry. Reiko Arita1, 7, N.
Morishige2, 7, T. Fujii3, 7, S. Fukuoka6, 7, J. Chung4,
K. Seo5, Y. Fukuda1, K. Itoh1. 1Itoh Clinic, Saitama,
Japan;2Ophthalmology, Yamaguchi University,
Ube, Japan; 3Development, Kowa, Tokyo, Japan;
4
Ophthalmology, Kim’s Eye Hospital, Konyang
University, Seoul, Korea (the Republic of);
5
Ophthalmology, Yonsei University college of
medicine, Seoul, Korea (the Republic of); 6Omiya
Hamada Ophthalmic Clinic, Saitama, Japan; 7Lid
and Meibomian Gland Working Group, Toko, Japan
*CR
2854 — A0063 Altered sub-basal nerve plexus,
increased dendritic cells, differential cytokine
profile and associated vitamin D deficiency
explains pain in evaporative dry eye (EDE).
Rashmi Deshmukh1, R. shetty1, A. Agrawal1,
A. Ghosh2, R. Shroff1. 1Cornea and Refractive
Services, Narayana Nethralya, Bangalore, India;
2
Narayana Nethralaya Foundation, GROW Research
Laboratory, Bangalore, India
2855 — A0064 A Comparison of SPEED
Scores in Contact Lens and Non-Contact Lens
Wearers. Andrew D. Pucker1, L. Jones-Jordan1, J.
T. Kwan2, C. Kunnen4, S. Srinivasan3. 1College of
Optometry, The Ohio State University, Columbus,
OH; 2Southern California College of Optometry,
Marshall B Ketchum, Fullerton, CA; 3School of
Optometry and Vision, University of Waterloo,
Waterloo, ON, Canada; 4College of Optometry,
University of Houston, Houston, TX *CR
2856 — A0065 Isotretinoin Study: Ocular
Surface Comparison between Exposed and
Unexposed Groups. Thao N. Yeh2, 1, M. C. Lin2, 1.
1
Vision Science Graduate Group, University of
California, Berkeley, Berkeley, CA; 2Clinical
Research Center, School of Optometry, University
of California, Berkeley, Berkeley, CA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
207
Tuesday Posters
8:30 am – 10:15 am
2838 — A0047 Discomfort over Time
Associated with various Ocular Demodex
Treatment Products. William Ngo1, L. W. Jones1,
S. Srinivasan1, E. Bitton2. 1University of Waterloo,
Waterloo, ON, Canada;2University of Montreal,
Montreal, QC, Canada *CR
2843 — A0052 Dry Eye Symptoms and Visual
Function with Digital Device Use. Jennifer
Harthan1, L. O’Dell6, 2, J. T. Kwan3, M. M. Hom7, S.
G. Hauswirth8, A. Schachter4, 9, S. Schachter4, 9, W.
Hauser5, A. Kabat5. 1Illinois College of Optometry,
Chicago, IL; 2Adjunct Clinical Faculty, Salus
University, Elkins Park, PA; 3Marshall B. Ketchum
University, Fullerton, CA; 4Adjunct Clinical
Faculty, SCCO, Fullerton, CA; 5Southern College of
Optometry, Memphis, TN; 6Private Practice, York,
PA; 7Private Practice, Azusa, CA; 8Private Practice,
Bloomington, MN; 9Private Practice, Pismo Beach,
CA *CR
2857 – 2874 – Tuesday – Posters
2857 — A0066 Development of the 2-item Daily
Ocular Symptoms Survey to assess day-to-day
fluctuations in discomfort and dryness. Archana
Boga, B. Golebiowski, F. Stapleton. Optometry,
University of New South Wales, Sydney, NSW,
Australia
Tuesday Posters
8:30 am – 10:15 am
2858 — A0067 Ocular Surface Thermal
Imaging in Normal and Dry Eye Subjects.
Michael Watson1, K. J. Lane2, E. Angjeli2, P.
Corcoran2, J. D. Rodriguez2, G. W. Ousler1. 1Dry
Eye, Ora, Inc., Andover, MA;2Research and
Development, Ora, Inc., Andover, MA *CR
2859 — A0068 Clinical findings of Dry Eye
Disease in a large Norwegian cohort based
on osmolarity measurements. Sjur Reppe1, X.
Chen3, 4, S. Ræder3, 4, T. P. Utheim2, 5, Ø. A. Utheim2,
A. Stojanovic4, 8, N. S. Lagali6, D. A. Dartt7, B.
Tashbayev3. 1Department of Medical Biochemistry,
Oslo University Hospital, Oslo, Norway;
2
Department of Ophthalmology, Oslo University
Hospital, Oslo, Norway; 3The Norwegian Dry
Eye Clinic, Oslo, Norway; 4Synslaser Surgery AS,
Oslo, Norway; 5Department of Ophthalmology,
Vestre Viken Hospital Trust, Drammen, Norway;
6
Department of Clinical and Experimental
Medicine, Linköping University, Linköping,
Sweden;7Department of Ophthalmology, Harvard
Medical School, Boston, MA; 8Eye Department,
University Hospital North Norway, Tromsø, Norway
2860 — A0069 Prevalence of hyperosmolarity
and symptoms of DED in the US population.
Venkiteshwar S. Manoj. Medical Affairs, TearLab
Corporation, Seattle, WA *CR
2861 — A0070 Tear Cytokine Biomarkers in
Dry Eye Patients Subjected to Environmental
Stress and Treated with Topical 0.1%
Fluorometholone. Margarita Calonge1, 2, J.
Pinto-Fraga1, 2, A. Enriquez-De-Salamanca1, 2, I.
Fernández2, 1, M. J. González-García1, 2, A. LópezMiguel1, 3, A. López-de-la-Rosa1, R. W. Beuerman4, 5,
V. L. Calder6, M. E. Stern7. 1Ophthalmology, IOBAUniversity of Valladolid, Valladolid, Spain;2CIBERBBN (Biomedical Research Networking Center in
Bioengineering, Biomaterials and Nanomedicine),
Madrid, Spain; 3VISION I+D, SL, Valladolid,
Spain; 4SILK, Department of Ophthalmology,
University of Tampere, Tampere, Finland;
5
Singapore Eye Research Institute, Singapore,
Singapore; 6University College London, UCL,
London, United Kingdom; 7Allergan Inc., Irvine,
CA *CR, f
2862 — A0071 Effect of punctal occlusion on
blinks in eyes with severe aqueous tear deficient
dry eye. Hiroaki Kato1, N. Yokoi1, R. Sakai1, M.
Niu1, A. Watanabe1, S. Kinoshita2, C. Sotozono1.
1
Department of Ophthalmology, Kyoto Prefectural
Univ of Medcine, Kyoto City Kamigyoku, Japan;
2
Department of Frontier Medical Science and
Technology for Ophthalmology, Kyoto Prefectural
Univ of Medicine, Kyoto, Japan *CR
2863 — A0072 Environmental nitration of
ocular lactoferrin may contribute to dry eye
disease. Amani Y. Alhalwani1, 2, J. E. Repine2, J. A.
Huffman1. 1Chemistry and biochemistry, University
of Denver, Englewood, CO; 2Webb-Waring Center,
University of Colorado School of Medicine,
Denver, CO
2864 — A0073 Randomized, controlled,
crossover trial comparing the impact of sham
or intranasal neurostimulation on conjunctival
goblet cell degranulation. Koray Gumus1, 3, K.
Schuetzle1, J. D. Loudin2, S. C. Pflugfelder1. 1Cullen
Eye Institute, Baylor College of Medicine, Houston,
TX; 2Allergan (Oculeve), South San Francisco, CA;
3
Department of Ophthalmology, Erciyes University
School of Medicine, Kayseri, Turkey *CR, f
2865 — A0074 Safety and efficacy of
ciclosporin 1 mg/mL cationic emulsion (CsA
CE) over 12 months in patients with severe dry
eye disease (DED) in the SANSIKA Phase III
trial. Gysbert B. Van Setten1, F. C. Figueiredo2, A.
Leonardi3, M. Amrane4, J. Garrigue4, D. Ismail4,
C. Baudouin5, 6. 1St Eriks Eye Hospital, Karolinska
Inst/St Eriks Eye Hosp, Danderyd, Sweden; 2Royal
Victoria Infirmary, Newcastle University, Newcastle
upon Tyne, United Kingdom; 3Department of
Neuroscience, Ophthalmology Unit, University of
Padua, Padua, Italy; 4Santen SAS, Evry, France;
5
Quinze-Vingts National Ophthalmology Hospital,
Paris, France; 6UPMC University, Paris, France
Vision Institute, INSERM UMRS968, CNRS
UMR7210, Paris, France *CR, f
2866 — A0075 Prospective, randomized trial
of the two mucin secretogogues for the treatment
of dry eye in office workers. Jun Shimazaki1, S.
Den-Shimazaki2, M. Saga3, K. Fukagawa4, 6, M.
Sakata5, M. Iwasaki4, T. Okano7. 1Ophthalmology,
Tokyo Dental College, Ichikawa, Japan; 2Shimazaki
Eye Cloinic, Tokyo, Japan; 3Ichikawa Shapo Eye
Clinic, Ichikawa, Japan; 4Ryogoku Eye Clinic,
Tokyo, Japan; 5Shinjuku Eye Clinic, Tokyo, Japan;
6
Iidabashi Eye Clinic, Tokyo, Japan; 7Smile Eye
Clinic, Yokohama, Japan *CR, f
2867 — A0076 Clinical Effects and Safety
of 3% Diquafosol Ophthalmic Solution for
Patients with Dry Eye after Cataract Surgery.
Dae Hyun Park, J. Chung, S. Lee. Ophthalmology,
Soonchunhyang University Hospital, Seoul, Korea
(the Republic of) f
2868 — A0077 The effect of topical rebamipide
on environmental stress induced dry eye in
the wild type mice. Takashi Kojima1, 2, O. M.
Ibrahim2, T. Inaba2, S. Nakamura2, M. Dogru2, K.
Tsubota2.1Ophthalmology, Gifu Red Cross Hospital,
Nagoya, Japan; 2Ophthalmology, Keio University
School of Medicine, Tokyo, Japan *CR
2869 — A0078 The effect of 3% diquafosol
sodium eye drops on the meibomian gland
alterations of the superoxide dismutase-1
knockout mice. Keisuke Ikeda1, 2, M. Dogru2, 1, M.
Kawashima1, T. Kojima1, K. Higa2, A. Igarashi2,
T. Yamaguchi2, S. Den-Shimazaki2, K. Tsubota1, J.
Shimazaki2. 1Keio University School of Medicine,
Tokyo, Japan; 2Ophthalmology, Tokyo Dental
College Ichikawa General Hospital, Ichikawa,
Japan *CR
2870 — A0079 Effect of 2% rebamipide
ophthalmic suspension in dry eye rabbit model.
Hiroshi Toshida1, T. Ohta1, C. Suto2, K. Shinji3,
M. Karasawa3, A. Murakami3. 1Ophthalmology,
Juntendo University Shizuoka Hospital, Izunokuni,
Japan; 2Ophthalmology, Saiseikai Kurihashi
Hospital, Saitama, Japan; 3Ophthalmology, Juntendo
University, Tokyo, Japan *CR
2871 — A0080 Pooling of two randomized
Phase III clinical trials of ciclosporin 1 mg/
mL cationic emulsion (CsA CE) as a treatment
for severe keratitis in patients with dry eye
disease (DED). Elisabeth Messmer1, A. Leonardi2,
M. Amrane3, D. Ismail3, F. C. Figueiredo4, C.
Baudouin5, 6. 1Department of Ophthalmology,
Ludwig-Maximilian-University Munich, München,
Germany; 2Department of Neuroscience,
Ophthalmology Unit, University of Padua, Padua,
Italy; 3Santen SAS, Evry, France; 4Royal Victoria
Infirmary, Newcastle University, Newcastle upon
Tyne, United Kingdom; 5Quinze-Vingts National
Ophthalmology Hospital, Paris, France; 6UPMC
University, Paris 6, Vision Institute, INSERM
UMRS968, CNRS UMR7210, Paris, France *CR, f
2872 — A0081 A Multi-Center Phase 3 Safety
and Tolerability Study of Isunakinra (EBI-005)
in Subjects with Moderate to Severe Dry Eye
Disease. Leontia Burke3, M. H. Goldstein1, 2, K. L.
Tubridy1.1Development, Eleven Biotherapeutics,
Cambridge, MA; 2New England Eye Center, Tufts
Medical Center, Boston, MA; 3Clinical Operations,
Eleven Biotherapeutics, Cambridge, MA *CR, f
2873 — A0082 The effect of TRPM8-agonist
menthol eyedrops on tear meniscus area and
height. Peter Corcoran2, E. Angjeli2, K. J. Lane2,
G. W. Ousler3, M. Watson3, M. B. Abelson1, 4.
1
Ophthalmology, Ora, Inc, Andover, MA; 2Research
and Development, Ora Institute, Andover, MA;
3
Dry Eye, Ora, Inc, Andover, MA; 4Ophthalmology,
Harvard Medical School, Boston, MA *CR
2874 — A0083 A Phase 3 Multi-Center,
Randomized Controlled Evaluation of the
Efficacy, Safety and Tolerability of Isunakinra
in Subjects with Moderate to Severe Dry Eye
Disease. Karen L. Tubridy, PharmD, 1 Michael H.
Goldstein, MD, 1,2 Marianne Magill, MS 1. 1 Eleven
Biotherapeutics (Cambridge, MA) 2 New England
Eye Center, Tufts Medical Center (Boston, MA).
Karen L. Tubridy1, M. H. Goldstein1, 2, M. Magill3.
1
Development, Eleven Biotherapeutics, Cambridge,
MA; 2New England Eye Center, Tuft’s Medical
Center, Boston, MA; 3Consultant, Natick, MA
*CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
208
Tuesday – Posters – 2875 – 2892
2875 — A0084 Safety, Tolerability and
Pharmacokinetics of P-321 Ophthalmic Solution
in Subjects with Mild to Moderate Dry Eye
Disease. Jose L. Boyer1, A. Woodring1, J. Ansede1,
W. Thelin1, M. R. Johnson1, K. N. Sall2, G. N.
Foulks3, R. C. Boucher4. 1Parion Sciences, Durham,
NC; 2Sall Research Medical Center, Artesia,
CA; 3University of Louisville, Louisville, KY;
4
University of North Carolina, Chapel Hill, NC
*CR, f
2877 — A0086 Efficacy of Topical Application
of a Transient Receptor Potential Melastatin
8 Agonist in Patients with Dry Eye. Kyung
Chul Yoon1, J. Yang1, Y. Kang1, L. Cui1, 2, Y. Li1, 2,
H. Lee1, I. You3.1Department of Ophthalmology,
Chonnam National University Medical School
and Hospital, Gwangju, Korea (the Republic of);
2
Department of Biomedical Science and Center for
Creative Biomedical Scientists, Chonnam National
University, Gwangju, Korea (the Republic of);
3
Department of Ophthalmology, Chonbuk National
University College of Medicine, Jeonju, Korea (the
Republic of) f
2878 — A0087 Results of clinical trials with a
novel RNA-based therapy (SYL1001) to treat
patients with ocular pain associated to dry eye
disease. Ana Isabel Jimenez1, J. M. Benitez Del
Castillo3, 8, J. Moreno-Montanes2, 8, I. JimenezAlfaro7, F. Muñoz-Negrete6, 8, K. Palumaa4, K.
Turman5, C. Paneda1, T. Martinez1, V. Ruz1, V.
Gonzalez1. 1Ophthalmology, Sylentis, Madrid,
Spain; 2Clinica Universidad Navarra, Pamplona,
Spain; 3Hospital Clínico San Carlos, Madrid, Spain;
4
East-Tallinn Central Hospital Eye Clinic, Madrid,
Spain; 5Eye Clinic Dr. Krista Turman, Tallin,
Estonia; 6Hospital Ramón y Cajal, Madrid, Spain;
7
Fundación Jiménez Díaz, Madrid, Spain; 8Oftared,
Madrid, Spain *CR, f
2879 — A0088 Clinical comparison of gel-type
artificial tears. Joseph G. Vehige2, M. M. Hom1, P.
A. Simmons2, D. A. Hollander2. 1Private Practice,
Azusa, CA; 2Allergan, Plc, Dublin, Ireland *CR, f
2881 — A0090 Effect of gel-based artificial
tears on tear film thickness in patients with dry
eye disease. Doreen Schmidl1, 2, K. Witkowska1, 2,
R. M. Werkmeister2, P. Wozniak1, A. Bata1, K.
Fondi1, C. Baar1, G. Garhofer1, L. Schmetterer1, 2.
1
Department of Clinical Pharmacology, Medical
University of Vienna, Vienna, Austria; 2Center
for Medical Physics and Biomedical Engineering,
Medical University of Vienna, Vienna, Austria f
2882 — A0091 Clinical Evaluation of Schirmer
Test Variations on the Predictability of Benefit
from Artificial Tears. Matthew Young1, H.
Zhong2, E. Peterson2, E. Patel2, D. Schwartz1, Y.
Michael1, C. Leffler1. 1Ophthalmology, Virginia
Commonwealth University, North Chesterfield,
VA; 2Virginia Commonwealth University School of
Medicine, Richmond, VA
Exhibit/Poster Hall A0143-A0182
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Cornea
311 Keratoconus and Collagen
Crosslinking
Moderators: May Griffith and Mark Yorek
2883 — A0143 Same Day vs. Sequential
CK+CXL in the Treatment of Ectasia. Olivia
Dryjski1, R. Rubinfeld2, 1, R. Lindstrom6, D. Kim2,
M. Choi2, S. Shetty3, R. Ambrosio5, A. Cummings4.
1
Ophthalmology, Medstar Georgetown University
Hospital/Washington Hospital Center, Washington,
DC; 2Ophthalmology, Re:Vision Private Practice,
Washington, DC; 3Ophthalmology, Weill Cornell
Medical College, New York Presbyterian
Hospital, New York, NY; 4Wellington Eye Clinic,
Beacon Hospital, Dublin, Ireland; 5Instituto de
Olhos Renato Ambrosio, Rio de Janeiro, Brazil;
6
Ophthalmology, Minnesota Eye Consultants,
University of Minnesota, Minneapolis, MN *CR, f
2884 — A0144 Monitoring of O2 concentrations
during Corneal Cross-Linking (CXL) by
Phosphorescence Lifetime Imaging Microscopy
(PLIM). Rebecca M. McQuaid1, M. C. Mrochen3,
R. Dmitriev2, D. Papkovski2, B. Vohnsen1.
1
Ophthalmology, Univ Coll Dublin/IROC
Innocross, Dublin, Ireland; 2School of Biochemistry
and Cell Biology, University College Cork, Cork,
Ireland; 3Ophthalmology, IROC Science AG,
Zurich, Switzerland
2885 — A0145 Corneal Collagen Crosslinking
and Intracorneal Ring Segments: Simultaneous
vs Sequential Surgery. Reda Issa1, P. S. Hersh1, S.
Greenstein2. 1Ophthalmology, Rutgers University
- New Jersey Medical School, Newark, NJ;
2
Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA f
2886 — A0146 Corneal Cross-Linking Before
Intrastromal Ring Segment Implantation
Decreases The Effectiveness Of The Rings. Lucia
Ibares-Frias1, 2, P. Gallego1, 3, R. Cantalapiedra3,
G. G. Gonçalves de Almeida Cunha3, J. MerayoLloves1, 4, M. Martínez-García1, 3. 1Group of Optical
Diagnostic Techniques, University of Valladolid,
Valladolid, Spain; 2Ophthalmology, Hospital Clínico
Universitario de Valladolid, Valladolid, Spain;
3
Cellular Biology, Histology and Pharmacology
Department, Faculty of Medicine, University
of Valladolid, Valladolid, Spain; 4Instituto
Universitario Oftalmológico Fernandez-Vega,
Oviedo, Spain
2887 — A0147 Corneal endothelial loss after
corneal crosslinking for keratoconus. Naoko
Kato1, 2, M. Shinzawa2, K. Konomi2, K. Kasai2, 3,
J. Shimazaki2. 1Department of Ophthalmology,
Saitama Medical University, Saitama, Japan;
2
Ophthalmology, Tokyo Dental College Ichikawa
General Hospital, Chiba, Japan; 3Department of
Ophthalmology, Jikei University, Tokyo, Japan
*CR, f
2888 — A0148 Biocompatible Chondroitin
sulfate-based cross-linker restores corneal
mechanics and collagen alignment. Xiaokun
Wang, J. Sohn, G. Ma, S. C. Yiu, J. Elisseeff.
ophthalmology, Johns Hopkins University,
Baltimore, MD
2889 — A0149 Effect of Epithelial Removal on
the Corneal Curvature in Keratoconic Eyes prior
to Crosslinking. Michael W. Belin1, J. C. Siordia2.
1
Ophthalmology, University of Arizona, Marana,
AZ; 2University of Arizona, Tucson, AZ *CR
2890 — A0150 One-year outcomes of changes
in corneal densitometry after accelerated
(45mW/cm2) transepithelial corneal collagen
cross-linking for keratoconus. Yang Shen, W. Jian,
L. Sun, M. Li, T. Han, M. Tian, X. Zhou. Eye and
ENT Hospital of Fudan University, Shanghai, China
2891 — A0151 Freiburg keratoconus
registry: Implementation and first findings of a
monocentric keratoconus registry. Stefan J. Lang,
D. Boehringer, T. Reinhard. Eye Center, AlbertLudwigs-University of Freiburg, Freiburg, Germany
2892 — A0152 Preliminary Results Of A
Randomized Controlled Trial Comparing
Transepithelial Corneal Cross-Linking With
Iontophoresis And Standard Cross-Linking
In Patients With Progressive Keratoconus.
sebastiano serrao1, G. Lombardo2, M. Rosati1, D.
schiano lomoriello1, M. Lombardo1. 1Fondazione
Bietti Roma, Rome, Italy; 2Consiglio Nazionale
delle Ricerche, Istituto per i Processi ChimicoFisici, Messina, Italy f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
209
Tuesday Posters
8:30 am – 10:15 am
2876 — A0085 Topical ocular ciclosporin 1 mg/
mL cationic emulsion in patients with dry eye
with severe keratitis: Experience through the
French early access program. Serge Doan1, P.
Pisella2, 3, B. Cochener4, M. Amrane5, D. Ismail5,
C. Baudouin6, 7, M. Labetoulle8. 1Ophthalmology,
Bichat Hospital & A de Rothschild Foundation,
Paris, France; 2University François Rabelais, Tours,
France; 3Department of Ophthalmology, Bretonneau
Hospital, Tours, France; 4Brest University Medical
School, Morvan Hospital, Brest, France; 5Santen
SAS, Evry, France; 6Quinze-Vingts National
Ophthalmology Hospital, Paris, France; 7UPMC
University, Paris 6, Vision Institute, INSERM
UMRS968, CNRS UMR7210, Paris, France;
8
Department of Ophthalmology, Bicêtre Hospital,
APHP, Paris-Sud University, Le Kremlin-Bicêtre,
France *CR, f
2880 — A0089 Fingerprick Autologous Blood
as a Novel Treatment for Dry Eye Syndrome and
Persistent Epithelial Defects. Jonathan Y. Than1,
J. Wawrzynski1, J. Moore2, A. Patel3, S. Shah4, N.
Nesaratnam1, A. Sharma1. 1Moorfields Eye Centre
at Bedford Hospital, London, United Kingdom;
2
The Royal Victoria Hospital, Belfast, United
Kingdom; 3Heart of England NHS Foundation
Trust, Birmingham, United Kingdom;4Birmingham
and Midland Eye Centre at City Hospital,
Birmingham, United Kingdom f
2893 – 2917 – Tuesday – Posters
2893 — A0153 Non invasive label free
hyperspectral method to assess corneal crosslinking efficacy. Giuseppe Lombardo1, V. Villari1,
N. Micali1, N. Leone1, M. Lombardo2. 1IPCF, CNR,
Messina, Italy;2IRCCS Fondazione G.B. Bietti,
Rome, Italy *CR
2894 — A0154 Correlation Between Eye
Rubbing And Keratoconus Severity In A
Treatment-Naive Keratoconic Population.
Mohamed Zaidi, L. Lhuillier, N. Ouamara, C. Goetz,
N. Houmad, S. Maxime, A. ehrhardt, J. Perone, O.
Guechi, A. Agapie, P. Krawczyk. Ophtalmology,
Regional Hospital of Metz Thionville (France),
Metz, France
Tuesday Posters
8:30 am – 10:15 am
2895 — A0155 Ultrastructural Study of
lamellar organization of Peripheral and Central
Stroma of Keratoconus Cornea. Aljoharah
Alkanaan2, 1, O. Kirat3, R. Barsotti2, T. Almubrad1,
A. Khan1, S. Akhtar1.1King Saud University, Riyadh,
Saudi Arabia; 2Salus University, Philadelphia, PA;
3
King Khaled Eye Specialist Hospital, Riyadh,
Saudi Arabia
2896 — A0156 A pilot study of corneal
sensitivity and its associations in keratoconus.
Preeji S. Mandathara1, F. Stapleton1, J.
Kokkinakis1, 2, M. D. Willcox1. 1School of Optometry
and Vision Science, University of New South
Wales, Randwick, NSW, Australia; 2The Eye
Practice, Sydney, NSW, Australia
2897 — A0157 Determining the Efficacy of
Corneal Cross-linking (CXL) Protocols for
Different Corneal Thicknesses: Theoretical
Model and Experimental Validation. Sabine
Kling1, 2, F. Hafezi2, 3.1Laboratory of Ocular Cell
Biology, University of Zurich, Zurich, Switzerland;
2
University of Geneva, Geneva, Switzerland;
3
ELZA Institute, Dietikon/Zurich, Switzerland
2898 — A0158 Four-year results of riboflavin
ultraviolet-A corneal collagen cross-linking for
progressive corneal ectasia in 129 eyes. Samar A.
Al-Swailem, S. Al Zaid. King Khaled Eye Specialist
Hosp, Riyadh, Saudi Arabia
2899 — A0159 Relationship between
repeatability in corneal topography parameters
and increased disease severity in keratoconic
eyes. Ciara Bergin, F. Majo, K. Hashemi, I.
Guber. Ophthalmology, Jules-Gonin Eye Hosptial,
Lausanne, Switzerland
2900 — A0160 Keratoconus is not attributable
to eye rubbing in a young Down’s syndrome
cohort. Stephanie Campbell, J. Woodhouse, K.
Meek. Cardiff Centre for Vision Sciences, Cardiff
University, Cardiff, United Kingdom
2901 — A0161 Stromal demarcation line: is it
predictive for Cross-Linking efficiency? Louis
Lhuillier1, N. Houmad1, M. Zaidi1, S. Maxime1, A.
Ehrhardt1, A. Agapie1, O. Guechi1, P. Krawczyk1, H.
Duong Nguyen Viet2, 1, J. Perone1. 1Ophthalmology,
CHR Metz, Metz, France; 2Hoang Quoc Hung
Hospital, Hô Chi Minh ville, Viet Nam
2902 — A0162 Correlation of Anterior
and Posterior Corneal Shape in Clinical
Keratoconus. Jaime Larrea Gonzalez1, A. J.
Ramirez-Miranda1, A. Navas1, E. O. GraueHernandez1, A. Jimenez-Corona2.1Cornea and
Refractive Surgery, Instituto de Oftalmología Conde
de Valenciana, Mexico City, Mexico; 2Research
& Evaluation, Instituto de Oftalmología Conde de
Valenciana, Mexico City, Mexico
2903 — A0163 To differentiating keratoconus
and contact lens-related corneal warpage by
combining pattern analysis of focal changes in
anterior corneal topography, pachymetry, and
epithelial thickness maps. Maolong Tang, Y. Li,
D. Huang. Oregon Health and Science University,
Portland, OR *CR
2904 — A0164 Outcome Of Implantable
Collamer Lens In Keratoconus. Salem G. Almalki.
Ophathalmology, King Khalid Eye Specialist
Hospital, Riaydh, Saudi Arabia
2905 — A0165 Is keratoconus risk associated
with genetic variation of aldehyde dehydrogenase
ALDH3A1 gene? Piotr Krawczyk1, 2, J. Perone1, A.
ambroziak2, J. giebultowicz2, O. Guechi1, A. agapie1,
N. Ouamara1, L. Lhuillier1, N. Houmad1, H. Duong
Nguyen Viet3, J. szaflik2. 1ophthalmology, Regional
hospital center, Mercy hospital, METZ cedex 03,
France; 2ophthalmology, Medical University of
Warsaw, Warsaw, Poland;3University of Medicine
and Pharmacy of Ho Chi Minh City, Ho Chi Minh
City, Viet Nam
2910 — A0170 Corneal Collagen Crosslinking
for progressive keratoconus: a prognosis factor
analysis. Everardo Hernandez-Quintela, M. CostaGonzález, N. Ramos Betancourt, M. Ramirez,
J. D. Martinez, V. Sánchez-Huerta. Cornea and
Refractive Surgery, Asociación para Evitar la
Ceguera en México, Hospital “Dr. Luis Sánchez
Bulnes”, Mexico City, Mexico
2911 — A0171 NC-1059 peptide-assisted
transepithelial riboflavin penetration in an exvivo rabbit corneal model. Daniel M. Gore3, P.
French1, D. O’Brart2, C. Dunsby1, B. D. Allan3.
1
Physics Department, Imperial College, London,
United Kingdom; 2Ophthalmology, St. Thomas’
Hospital, London, United Kingdom; 3External
Disease Service, Moorfields Eye Hospital, London,
United Kingdom *CR
2912 — A0172 Alterations to Bowman’s layer
and local molecular deregulation driving focal
corneal weakening: new evidence towards
Keratoconus etiopathogenesis. Natasha Pahuja1,
N. R. Kumar2, R. SHROFF1, R. shetty1, A. Sinha
Roy2, A. Ghosh2. 1Cornea-Refractive, Narayana
Nethralaya, Pune, India; 2Narayana Nethralaya,
Bangalore, India *CR, f
2913 — A0173 Characteristics of corneal
astigmatism of anterior and posterior surface in
healthy individuals and keratoconus patients.
Ingo Schmack, G. Shajari, M. PourSadeghian, M.
Remy, F. Hengerer, T. Kohnen. Ophthalmology,
Goethe-University, Frankfurt, Germany
2906 — A0166 Hair cortisol analysis in
progressive and stable keratoconus patients.
Janine Lenk, E. Spoerl, L. E. Pillunat, F. Raiskup.
Department of Ophthalmology, Univ. Hospital Carl
Gustav Carus, TU Dresden, Dresden, Germany
2914 — A0174 The role of Transforming
growth factor beta 2 (TGF-beta 2) in the
pathogenesis of keratoconus. Omer Iqbal, W.
Brambl, C. Bouchard. Ophthalmology, Loyola
University Chicago, Maywood, IL
2907 — A0167 Collagen arrangement from
Second Harmonic Microscopy in corneas
following cross-linking. James Germann, E.
Martinez-Enriquez, S. Marcos. Instituto de Óptica,
CSIC, Madrid, Spain
2915 — A0175 In-vivo Penetration of WST11
to the Corneal Stroma using Dextran with
Various Molecular Weights. Arie Marcovich1, 2, A.
Brandis1, I. Samish1, I. Pinkas1, I. Feine1, A. Goz1, 2,
Y. Salomon3, A. Scherz1. 1Plant and Environmental
Sciences, Weizmann Institute of Science, Rehovot,
Israel; 2Ophthalmology, Kaplan Medical Center,
Rehovot, Israel; 3Biological Regulation, Weizmann
Institute of Science, Rehovot, Israel *CR
2908 — A0168 An ex vivo investigation into the
effect of accelerated crosslinking using pulsed
and continuous UVA irradiation modes on
corneal enzymatic resistance. Nada H. Aldahlawi1,
S. Hayes1, D. P. O’Brart2, A. Akhbanbetova1, S. L.
Littlechild1, K. M. Meek1. 1School of Optometry
and Vision Sciences, Cardiff University, Cardiff,
United Kingdom; 2Department of Ophthalmology,
Keratoconus Research Institute St Thomas Hospital,
London, United Kingdom
2909 — A0169 Is topography guided
crosslinking the next stage in the evolution
of crosslinking: Refractive, keratometric and
biomechanical outcomes. Aarti Agrawal1, N.
Pahuja1, R. shetty1, A. Ghosh2, A. Sinha Roy2.
1
Cataract and refracrive surgery, Narayana
Nethralaya, Mumbai, India; 2Narayana Netharalaya,
Bangalore, India *CR
2916 — A0176 Functional And Anatomical
Modifications In A Six-Month Follow-up Of
Patients Treated With Collagen Cross-linking.
Riccardo Scotto, D. Musetti, F. Licata, C. E.
Traverso. DiNOGMI, University of Genoa,
Genova, Italy
2917 — A0177 Trans-Epithelial Accelerated
Corneal Cross-linking for Keratoconus in
Children: 18 month follow-up. Alejandro Navas,
A. Olivo-Payne, A. Abdala, E. Hernandez-Bogantes,
A. J. Ramirez-Miranda, E. O. Graue-Hernandez.
Instituto de Oftalmologia - Catarata, Institute of
Ophthalmology “Conde de Valenciana”,
Mexico City, Mexico
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
210
Tuesday – Posters – 2918– 2937
2918 — A0178 Health-Related Quality of Life
Improvement in Keratoconic Patients Subjected
to the Athens Protocol Treatment. Ioannis
Datseris1, G. Asimellis2, 3, A. J. Kanellopoulos3, 4.
1
OMMA Surgical, Athens, Greece; 2Kentucky
College of Optometry, Pikeville, KY; 3LaserVision.
gr Clinical & Research Eye Institute, Athens, Greece;
4
Ophthalmology, NY University, NY, NY *CR
2919 — A0179 The persistence of pain relief
after corneal crosslinking in mild bullous
keratopathy eyes. Takashi Ono1, Y. Terada2, Y.
Mori1, R. Nejima1, M. Ogata1, K. Minami1, K.
Miyata1. 1Miyata Eye Hospital, Miyakonojo, Japan;
2
Tokyo Metropolitan Geriatric Hospital,
Itabashi-ku, Japan
2920 — A0180 Correlation between central
stromal demarcation line depth and flattening of
the cornea after corneal cross-linking comparing
two different treatment protocols. Niklas
Pircher, A. Gschliesser, R. Donner, J. Lammer, G.
Schmidinger. Ophthalmology, Medical University
of Vienna, Wien, Austria
2922 — A0182 Trans-epithelial and Stromal
Pulsed-Light Accelerated Corneal Cross-linking
for Patients with Progressive Keratoconus.
Andrew Olivo-Payne, A. Abdala, E. HernandezBogantes, A. J. Ramirez-Miranda, A. Navas, D.
Loya, E. O. Graue-Hernandez. Department of
Ophthalmology, Instituto de Oftalmologia Conde de
Valenciana, Mexico City, Mexico
Exhibit/Poster Hall A0272-A0305
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Glaucoma
312 Glaucoma Surgery I
Moderators: Beth Edmunds, Leonard Seibold and
Mark R. Lesk
2923 — A0272 Cell adhesion and protein
adsorption studies of 3D printed photopolymers.
Richard M. Lee1, 2, M. Alband2, M. Penny2, S. T.
Hilton2, S. Brocchini1, 2, P. T. Khaw1. 1National
Institute for Health Research (NIHR) Biomedical
Research Centre at Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, London, United Kingdom; 2UCL
School of Pharmacy, London, United Kingdom
2925 — A0274 Collagen VIII and XI as
Biomarkers for Post-operative Conjunctival
Fibrosis. Tina T. Wong2, 3, L. Toh2, S. Chu2, J.
Chua1, L. Seet2, 3. 1Singapore National Eye Centre,
Singapore National Eye Centre, Singapore,
Singapore; 2Ocular Therapeutics and Drug Delivery,
Singapore Eye Research Institute, Singapore,
Singapore; 3Duke NUS Medical School,
Singapore, Singapore
2926 — A0275 Utility of purified collagenase
(Xiaflex®) as a possible aid in glaucoma
surgery: A pilot study. Robert A. Honkanen1, K.
Kaplowitz1, E. Yung1, A. G. Fong1, J. P. Wright2.
1
Ophthalmology, SUNY Stony Brook, Stony Brook,
NY; 2School of Medicine, Stony Brook University,
Stony Brook, NY *CR
2927 — A0276 Novel MRTF/SRF inhibitors
prevent conjunctival scarring after glaucoma
filtration surgery: An ex vivo and in vivo study.
Cynthia Yu-Wai-Man3, R. M. Lee3, S. Larsen1,
R. Neubig2, P. T. Khaw3. 1Vahlteich Medicinal
Chemistry Core, College of Pharmacy, University
of Michigan, MI; 2Department of Pharmacology
and Toxicology, Michigan State University, MI;
3
National Institute for Health Research (NIHR)
Biomedical Research Centre at Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom
2928 — A0277 Effects of rho-associated protein
kinase inhibitor Y-27632 on scarring formation
after glaucoma filtration surgery. Hideaki
Okumichi, W. Iwata, S. Okimoto, J. Ko, Y. Kiuchi.
Department of Ophthalmology and Visual Science,
Institute of Biomedical and Health Sciences,
Hiroshima University, Hiroshima, Japan
2929 — A0278 Effects of ripasudil (K-115),
a Rho kinase inhibitor, on the activation of
human conjunctival fibroblasts. Akiko Futakuchi,
T. Inoue, T. Fujimoto, M. M. Inoue, H. Tanihara.
Ophthalmology, Kumamoto University Hospital,
Chuo-ku, Kumamoto city, Japan *CR
2930 — A0279 Anti-fibrotic effect of a
multilayered nanoparticle system for delivery
of siSPARC in a mouse model of experimental
glaucoma surgery. Yang Fei Tan1, 2, L. Seet2, L.
Toh2, S. Venkatraman1, T. T. Wong2, 1. 1Nanyang
Technological University, Singapore, Singapore;
2
Singapore Eye Research Institute, Singapore,
Singapore
2931 — A0280 The antiproliferative effect
of bevacizumab on human tenon fibroblasts
is presumably not through VEGF inhibition.
Charlotte Fischer, V. Mans, N. Feltgen, H. Hoerauf,
C. van Oterendorp. Ophthalmology, University
medicine Goettingen, Germany, Goettingen, Germany
2932 — A0281 Lipid nanoemulsion associated
with paclitaxel as a new antiscarring agent in
experimental glaucoma surgery. Vital P. Costa1,
M. Occhiutto1, F. R. Freitas2, P. Picciarelli2,
R. Maranhao2.1Ophthalmology, University of
Campinas, Sao Paulo, Brazil; 2INCOR, University
of Sao Paulo, Sao Paulo, Brazil *CR
2933 — A0282 Effects of gelatin hydrogel
containing transforming growth factor-β
antibody in a canine filtration surgery model.
Michiko Miki1, S. Kojima1, T. Sugiyama2, D.
Jin3, S. Takai3, R. Kohmoto1, M. Ueki1, T. Ikeda1.
1
ophthalmology, Osaka Medical College, Takatsukicity, Japan; 2Nakano Eye Clinic, Kyoto, Japan;
3
Pharmacology, Osaka Medical College,
Takatsuki, Japan
2934 — A0283 Effect of Uveitis Activity on
Surgical Outcomes in Uveitic Glaucoma. Hye Jin
Kwon1, 2, W. L. Tao1, L. L. Lim1, 2, J. G. Crowston1, 2,
J. Ruddle1, 2, G. Y. Kong1, 2. 1Department of
Ophthalmology, Royal Victorian Eye and Ear
Hospital, East Melbourne, VIC, Australia;
2
Department of Ophthalmology, Centre for Eye
Research, East Melbourne, VIC, Australia
2935 — A0284 Subconjunctival injection vs
surgical sponge application of mitomycin-C
(MMC) during trabeculectomy in a county clinic.
Mallika Doss1, 2, A. Z. Chuang1, L. Blieden1, 2. 1Ruiz
Department of Ophthalmology and Visual Science,
The University of Texas Health Science Center
(UTHealth) McGovern Medical School, Houston,
TX; 2Robert Cizik Eye Clinic, Houston, TX
2936 — A0285 Comparison of intraoperative
injection of Mitomycin (MMC) versus
conventional sponge-applied MMC during
double site phaco-trabeculectomy. Vivek
Pullutipadath Sasikumar1, S. Reich2, M. Pillai1, A.
Kanathia1, S. Priya1, P. S1, J. Serle2. 1Aravind Eye
Center, India, India; 2Ophthalmology, Icahn School
of Medicine of Mount Sinai Hospital, New York,
NY *CR, f
2937 — A0286 Does type of postoperative antiglaucoma drug affect morphological changes of
filtering bleb after trabeculectomy? - Utilizing
the data from the Collaborative Bleb-Related
Infection Incidence and Treatment Study. Yuji
Yamamoto1, K. Mori1, I. Yokota2, Y. Ikeda1, M.
Ueno1, K. Imai1, H. Yoshikawa1, S. Teramukai2, S.
Kinoshita1, C. Sotozono1. 1Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan;
2
Biostatistics, Kyoto Prefectural University of
Medicine, Kyoto, Japan
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
211
Tuesday Posters
8:30 am – 10:15 am
2921 — A0181 Progression after corneal crosslinking in keratoconus eyes with KMax≥58.0 D.
Samuel J. Küchler1, C. Tappeiner1, D. Epstein2, B.
E. Frueh1. 1Ophthalmology, University Hospital
Berne, Berne, Switzerland; 2Private Practice,
Berne, Switzerland
2924 — A0273 Conjunctival tissue proteome
demonstrates abnormal expression of wound
response proteins in glaucoma patients. Hannu
M. Uusitalo1, 2, A. Jylhä1, J. Nättinen1, 3, A.
Vaajanen2, M. Härkönen2, M. Nykter3, L. Zhou4,
R. W. Beuerman1, 4. 1Ophthalmology, SILK, PPM,
University of Tampere, Tampere, Finland; 2Tays
Eye Center, Tampere University Hospital, Tampere,
Finland; 3BioMediTech, University of Tampere,
Tampere, Finland; 4SERI, Singapore, Singapore
2938 – 2958 – Tuesday – Posters
2938 — A0287 Safety and Efficacy of
Trabeculectomy with Mitomycin C Injection. Sze
H. Wong1, S. M. Walsman2, 1, A. S. Khouri1. 1Institute
of Ophthalmology and Visual Science, Rutgers New
Jersey Medical School, Newark, NJ; 2Hudson Eye
Physicians and Surgeons, Jersey City, NJ
2939 — A0288 Non-penetrating deep
sclerectomy versus trabeculectomy for open
angle glaucoma in Mexican population. David
Berrones Medina, A. Hernández-Vargas, J. JimenezArroyo, A. Castillejos- Chévez, J. Jiménez-Roman.
Ophthalmology, Asociación para Evitar la Ceguera
en Mexico, Mexico City, Mexico
2940 — A0289 Attaining intraocular pressure
of 10 mmHg or less: a comparison of tube
and trabeculectomy surgery in eyes with
pseudophakic glaucoma and initial glaucoma
surgery. Alissa Meyer, K. Harbie, C. Rodgers,
N. Rosenberg, M. B. Sherwood. Ophthalmology,
University of Florida, Gainesville, FL
Tuesday Posters
8:30 am – 10:15 am
2941 — A0290 Changes in Cup-to-Disc Ratio
Following Trabeculectomy. Cassie N. Confait, O.
Idowu, M. Moroux. Ophthalmology, University of
Mississippi Medical Center, Madison, MS
2942 — A0291 Aberrometric changes induced
by trabeculectomy performed in an Argentinian
teaching hospital. Pablo R. Ruisenor Vazquez, J.
F. Casiraghi. Glaucoma Section, Ophthalmology
Division, Hospital de Clínicas, University of
Buenos Aires, Capital Federal, Argentina
2943 — A0292 Toric intraocular lens in patients
with glaucoma undergoing phacoemulsification
and trabeculectomy: two years follow-up. Yael
Azses, A. Garcés-Valencia, C. Prado Larrea, R.
Castañeda Diez, J. Jiménez-Roman. Asociación
para evitar la ceguera en México, Mexico City,
Mexico
2944 — A0293 Long-term outcomes of
trabeculectomy in contact lens wearers. Jose
A. Paczka1, 2, L. A. Giorgi-Sandoval2, 3, A. OrozcoGarcía4, 2. 1Institute of Ophthalmology and Visual
Sciences, University of Guadalajara, Guadalajara,
Mexico; 2Research, Unidad de Diagnostico
Temprano del Glaucoma, Guadalajara, Mexico;
3
Research, Asistencia e Investigacion en Glaucoma,
Guadalajara, Mexico; 4Ophthalmology, Antiguo
Hospital Civil de Guadalajara, Guadalajara, Mexico
2945 — A0294 Risk of Surgical Failure in
Patients with Hypotony after Trabeculectomy.
Carole H. Kim1, V. L. Tseng1, 2, P. Romero1, F.
Yu1, 3, J. Caprioli1, H. Quarry1, A. L. Coleman1, 2.
1
Stein Eye Institute, David Geffen School of
Medicine at UCLA, Los Angeles, CA; 2Department
of Epidemiology, UCLA Fielding School of
Public Health, Los Angeles, CA; 3Department of
Biostatistics, UCLA Fielding School of Public
Health, Los Angeles, CA *CR
2946 — A0295 Effect and Risk Factor for
Failure of Trabeculectomy in the Glaucoma
Patients with Low Baseline Intraocular Pressure
in the Collaborative Bleb-Related Infection
Incidence and Treatment Study. Yosuke Miyoshi1,
H. Sakata1, Y. Kiuchi1, Y. Sugimoto2, Y. Murakami3,
T. Higashide4, K. Sugiyama4. 1Ophthalmology,
Hiroahima University Hospital, Hiroshima, Japan;
2
Ophthalmology, Hiroshima Prefectural Hospital,
Hiroshima, Japan; 3Ophthalmology, Hiroshima Red
Cross Hospital & Atomic-bomb Survivors Hospital,
Hiroshima, Japan; 4Ophthalmology, Kanazawa
University Hospital, Kanazawa, Japan
2947 — A0296 Early Postoperative
Complications of the Ex-PRESS Implantation
versus Trabeculectomy: A Randomized Clinical
Trial. Shogo Arimura, Y. Takihara, S. Miyake, K.
Iwasaki, M. Gozawa, T. Matsumura, T. Tomomatsu,
Y. Takamura, M. Inatani. Ophthalmology,
University of Fukui, Fukui, Japan f
2948 — A0297 The evaluation of the safety
of a self-assembling peptide gel as a potential
device for providing a clear operative field
in the trabeculectomy. Kenji Matsushita1,
R. Kawashima1, K. Uesugi1, 2, H. Okada2, H.
Sakaguchi1, K. Nishida1. 1Ophthalmology, Osaka
University Medical School, Suita, Japan; 2Menicon
Co., Ltd., Kasugai, Japan *CR
2949 — A0298 Trabeculectomy in Both Eyes;
the First-Operated Versus the Second-Operated
Eyes: A Comparative, Multicenter Study. Kentaro
Iwasaki1, Y. Takamura1, T. Nishida2, A. Sawada2,
K. Iwao3, A. Shinmura5, S. Kunimatsu-Sanuki4, H.
Tanihara3, K. Sugiyama5, T. Nakazawa4, M. Inatani1.
1
ophthalmology, University of Fukui, Fukui, Japan;
2
University of Gifu, Gifu, Japan; 3University of
Kumamoto, Kumamoto, Japan; 4University of
Tohoku, Tohoku, Japan; 5University of Kanazawa,
Kanazawa, Japan
2950 — A0299 Hypotony Maculopathy after
Trabeculectomy. Victoria L. Tseng1, 2, A. L.
Coleman1, 2, P. Romero1, F. Yu1, K. W. RobertsonBrown1, J. Caprioli1. 1UCLA/Stein Eye Institute,
Los Angeles, CA;2Epidemiology, UCLA Fielding
School of Public Health, Los Angeles, CA *CR
2951 — A0300 Uveitis, Glaucoma, Hyphema
Syndrome: A Referral-Based, Retrospective
Analysis. Trevor A. Smith, A. Cheung, J. C. Hart,
C. Chen. Ophthalmology, Beaumont Health - Royal
Oak, Royal Oak, MI
2952 — A0301 Early post-operative wound
leak after trabeculectomy with mitomycin C with
and without placement of bandage contact lens.
Ingrid Chang, K. D. Bojikian, D. Gupta, P. P. Chen.
Ophthalmology, University of Washington,
Seattle, WA
2953 — A0302 The effect of trabeculectomy
surgery on the central visual field in patients
with glaucoma and an established central visual
field defect using Micro-perimetry and Optical
coherence tomography. Gokulan Ratnarajan1, 2,
J. K. Jolly2, 3, J. Salmon2. 1Ophthalmology, Queen
Victoria Hospital, Chalfont St Peter, United
Kingdom; 2Oxford Eye Hospital, Oxford, United
Kingdom; 3Nuffield Laboratory of Ophthalmology,
Oxford, United Kingdom f
2954 — A0303 The effect of intraoperative
application of chemically defined bioadhesive
powder for trabeculectomy in rabbit eyes.
Yoshifumi Okamoto1, S. Hoshi1, M. Arai2, G.
Kishino1, F. Okamoto1, T. Oshika1. 1University
of Tsukuba, Tsukuba, Japan; 2Arai Eye Clinic,
Fukuoka, Japan
2955 — A0304 Second Trabeculectomy
After Failure of The First Trabeculectomy :
Outcomes and Risk Factors for Failure. Pradtana
Hirunpatravong, R. Alizadeh, P. Romero, K. NouriMahdavi, J. Caprioli. Ophthalmology, Glaucoma
division, JSEI, UCLA, Los Angeles, CA
2956 — A0305 Alteration of lymphatic vessels
after filtration surgery in mouse. Akira Matsuda,
Y. Asada, S. Iwamoto, J. Sugita. Ophthalmology,
Juntendo Univ School of Med, Tokyo, Japan
Exhibit/Poster Hall A0306-A0351
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Glaucoma
313 Glaucoma Blood Flow
Moderators: Yali Jia and Ruikang K. Wang
2957 — A0306 Optic disc perfusion in eyes
with primary open angle glaucoma and normal
tension glaucoma using optical coherence
tomography-based microangiography. Karine D.
Bojikian1, C. Chen2, J. C. Wen1, Q. Zhang2, C. Xin2,
D. Gupta1, R. C. Mudumbai1, M. A. Johnstone1, R.
K. Wang2, 1, P. P. Chen1. 1Ophthalmology, University
of Washington, KIRKLAND, WA; 2Bioengineering,
University of Washington, Seattle, WA *CR
2958 — A0307 OCT Angiography Vessel
Density in Normal, Glaucoma Suspects and
Glaucoma Eyes: Structural and Functional
Associations in the Diagnostic Innovations in
Glaucoma Study (DIGS).Adeleh Yarmohammadi1,
L. M. Zangwill1, A. Diniz-Filho1, M. Suh1, 2, P.
C. Manalastas1, N. Fatehee1, A. Belghith1, S.
Yousefi1, F. A. Medeiros1, R. N. Weinreb1. 1Hamilton
Glaucoma Center, Shiley Eye institute, Department
of Ophthalmology, University of Callifornia San
Diego, La Jolla, CA; 2Inje University, college of
medicine, Haeunda Paik Hospital, Busan, Korea
(the Republic of) *CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
212
Tuesday – Posters – 2959 – 2978
2959 — A0308 OCT Angiography of the
Optic Nerve Head to differentiate normal from
glaucoma eyes. Manuele Michelessi1, G. Manni2, L.
Tanga1, M. Ferrazza1, F. Berardo1, G. Roberti1, E.
Elmo2, F. Oddone1. 1IRCCS - Fondazione GB Bietti,
Rome, Italy; 2University of Rome Tor Vergata,
Rome, Italy
2960 — A0309 Comparison of the Optic
Disc Microvascular and Structure in Open
Angle Glaucoma Patients and Related Factors.
Kimikazu Sakaguchi, T. Higashide, S. Udagawa,
S. Ohkubo, K. Sugiyama. Dept of Ophthalmology,
Kanazawa University, Kanazawa, Japan f
2961 — A0310 Optical coherence tomography
angiography in glaucoma. Jens Ulrich Werner,
C. Enders, G. K. Lang, G. E. Lang. Department of
Ophthalmology, University of Ulm, Ulm, Germany
*CR
2963 — A0312 Normalization of Retinal
Vessel Density profile in healthy subjects. Ivania
Pereira1, 2, H. Resch2, S. Holzer2, F. Schwarzhans1,
J. Wu3, G. Fischer1, C. Vass2. 1Center for Medical
Statistics Informatics and Intelligent Systems,
Section for Medical Information Management
and Imaging, Medical University Vienna, Vienna,
Austria; 2Department of Ophthalmology, Medical
University of Vienna, Vienna, Austria; 3Christian
Doppler Labor for Ophthalmic Image Analysis
(OPTIMA), Department of Ophthalmology,
Medical University of Vienna, Vienna, Austria *CR
2964 — A0313 Evaluation of retinal vessel
morphology in Open Angle Glaucoma using
a novel Optical Coherence Tomography
based method. Robert Kromer1, 3, S. Boelefahr1,
A. Bartels2, S. C. Beutelspacher3, M. Klemm1.
1
Department of Ophthalmology, Hamburg
Medical Center Hamburg-Eppendorf, Hamburg,
Germany; 2Vision Systems, Hamburg University
of Technology, Hamburg, Germany; 3Department
of Ophthalmology, Ruprecht-Karls-University
Heidelberg, Medical Faculty Mannheim,
Mannheim, Germany
2965 — A0314 Phenotype of a Subgroup of
Primary Open Angle Glaucoma Patients with
Optic Nerve Susceptibility. Reza Alizadeh, P.
Hirunpatravong, P. Romero, J. Caprioli. Glaucoma,
Jules Stein Eye Institute, University of California,
Los Angeles, CA
2967 — A0316 Association between retinal
microcirculation perfusion and retinal thickness
at macula region in glaucoma patients: An
Optical Coherence Tomography Angiography
study. Huan Xu, X. Kong. Ophthalmology and
Vision Science, Eye and ENT hospital,Fudan
University,Shanghai,China, Shanghai, China
2968 — A0317 Retinal vascular caliber in
normal-tension glaucoma patients according
to visual field severity. Kojiro Imai2, K. Mori1, Y.
Ikeda1, 3, M. Ueno1, H. Yoshikawa1, Y. Maruyama1,
Y. Yamamoto1, S. Kinoshita4, C. Sotozono1.
1
Department of Ophthalmology, Kyoto Prefectural
Univ of Med, Kyoto, Japan; 2Department for
Medical Innovation and Translational Medical
Science, Kyoto Prefectural Univ. of Med., Kyoto,
Japan;3Oike-Ikeda Eye Clinic, Kyoto, Japan;
4
Department of Frontier Medical Science and
Technology for Ophthalmology, Kyoto Prefectural
Univ. of Med., Kyoto, Japan
2969 — A0318 Total retinal blood flow in
healthy and glaucomatous human eyes measured
with 3 beam Doppler optical coherence
tomography. Richard Haindl1, A. Wartak1, W.
Trasischker1, 2, B. Baumann1, M. Pircher1, C. K.
Hitzenberger1. 1Medical University of Vienna,
Vienna, Austria; 2Harvard Medical School and
Wellman Center for Photomedicine, Massachusetts
General Hospital, Boston, MA
2970 — A0319 Primary angle-closure glaucoma
causes significant decrease in both retinal
ganglion cell complex thickness and optic nerve
blood flow. Hideki Fukuoka, R. N. Weinreb, N.
A. Afshari. Shiley Eye Institute, University of
California, San Diego, La Jolla, CA
2971 — A0320 Preperimetric glaucoma
study 2: The relationship between optic nerve
head blood flow and visual field progression
in preperimetric glaucoma. Yukihiro Shiga1, N.
Aizawa1, S. Tsuda1, K. Omodaka1, Y. Yokoyama1, T.
Yasui2, K. Kato3, T. Nakazawa1. 1Ophthalmology,
Tohoku University, Sendai, Japan; 2Yasui Eye
Clinic, Sendai, Japan; 3Kato Eye Center, Sendai,
Japan *CR, f
2972 — A0321 Baseline retrobulbar blood flow
velocities correlate more strongly with changes
in retinal capillary density over 4 years in open
angle glaucoma patients with diabetes mellitus.
Casey Seizys1, A. Harris1, A. Verticchio Vercellin2,
N. Moore1, A. Huang1, D. WuDunn1, G. Eckert3,
B. A. Siesky1. 1Ophthalmology, Indiana University
School of Medicine, Indianapolis, IN; 2University
Eye Clinic, IRCCS Policlinico San Matteo, Pavia,
Italy; 3Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
2973 — A0322 Baseline retrobulbar blood
flow correlates more strongly with longitudinal
changes in macular structure in glaucoma
patients of African descent. Alice Chandra
Verticchio Vercellin4, A. Harris1, B. A. Siesky1,
A. Huang1, C. Ridenour1, I. Januleviciene2, L.
Siaudvytyte2, G. Eckert3, N. Moore1, T. A. Ciulla1.
1
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN; 2Ophthalmology,
Lithuanian Univ of Health Sciences, Kaunas,
Lithuania; 3Biostatistics, Indiana University School
of Medicine, Indianapolis, IN; 4University Eye
Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
*CR
2974 — A0323 Ophthalmic artery blood flow
velocities predict functional and structural
glaucoma progression after 5 years. Andrew
Huck1, A. Harris1, A. Verticchio Vercellin2, N.
Moore1, T. J. Knight1, C. C. Frye1, G. Eckert3, B.
A. Siesky1. 1Ophthalmology, Indiana University
School of Medicine, Indianapolis, IN; 2University
Eye Clinic, IRCCS Policlinico San Matteo, Pavia,
Italy; 3Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
2975 — A0324 Association of optic disc
haemorrhages in open angle glaucoma with
vascular symptoms. Gregor Thomaschewski, K. R.
Pillunat, E. Spoerl, L. E. Pillunat. Ophthalmology,
Univ Clinic Carl Gustav Carus Dresden, Dresden,
Germany f
2976 — A0325 Systemic and local factors
related to optic nerve head blood flow in patients
with glaucoma. Yutaro Yamada, T. Higashide, S.
Takeshima, S. Udagawa, K. Sugiyama. Kanazawa
University, Kanazawa, Japan f
2977 — A0326 Alzheimer’s disease and
primary open angle glaucoma may share nailfold
capillary abnormalities. Paul A. Knepper1, 2,
C. Cousins3, K. Carey1, I. Bielskus1, M. Patel1,
N. J. Volpe2, T. Patrianakos4, M. Giovingo4, L.
R. Pasquale5, R. Stern3. 1Ophthalmology and
Visual Sciences, University of Illinois at Chicago,
Chicago, IL; 2Ophthalmology, Northwestern
University, Chicago, IL; 3Neurology, Boston
University, Boston, MA; 4Ophthalmology, John H.
Stroger, Jr. Hospital, Chicago, IL; 5Ophthalmology,
Massachusetts Eye and Ear Infirmary, Boston, MA
*CR
2978 — A0327 Systemic blood and ocular
perfusion pressures influence retrobulbar
blood flow in open-angle glaucoma patients
with diabetes mellitus. Betul Kaskan1, A. Harris1,
N. Moore1, A. Verticchio Vercellin2, R. Frantz1,
C. Jonescu-Cuypers1, G. Eckert3, B. A. Siesky1.
1
Ophthalmology, Indiana University School of
Medicine, Istanbul, Turkey; 2University Eye
Clinic, IRCCS Policlinico San Matteo, Pavia,
Italy; 3Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
213
Tuesday Posters
8:30 am – 10:15 am
2962 — A0311 OCT Angiography Macular
Vessel Density, Ganglion Cell Complex Thickness
and Visual Fields in Healthy, Glaucoma Suspect
and Glaucomatous Eyes. Naeem Fatehee2, 1, L. M.
Zangwill2, 1, A. Diniz-Filho2, 1, A. Yarmohammadi2, 1,
M. H. Suh2, 1, P. C. Manalastas2, 1, A. Belghith2, 1,
S. Yousefi2, 1, F. A. Medeiros2, 1, R. N. Weinreb2, 1.
1
Shiley Eye Institute, University of California San
Diego, La Jolla, CA;2Hamilton Glaucoma Center,
La Jolla, CA *CR
2966 — A0315 Correlation between isolated
hemifield defects, OCT-based microangiography
(OMAG) and the macular vulnerability zone
(MZV). Yungtai Kung1, C. Chen1, 2, P. P. Chen1,
Q. Zhang1, 2, R. K. Wang1, 2, R. C. Mudumbai1.
1
Ophthalmology, University of Washington, Seattle,
WA; 2Bioengineering, University of Washington,
Seattle, WA *CR
Tuesday Posters
8:30 am – 10:15 am
2979 – 2996 – Tuesday – Posters
2979 — A0328 Diabetic status influences
retrobulbar blood flow involvement in
glaucomatous functional progression over five
years. Colin Ridenour1, A. Harris1, B. A. Siesky1,
A. Verticchio Vercellin2, T. J. Knight1, A. Huang1,
J. Carr1, G. Eckert3, N. Moore1. 1Ophthalmology,
Indiana University School of Medicine, Avon,
IN; 2University Eye Clinic, IRCCS Policlinico
San Matteo, Pavia, Italy; 3Biostatistics, Indiana
University School of Medicine, Indianapolis, IN
*CR
2985 — A0334 Lower baseline ophthalmic
artery blood flow velocities predict glaucomatous
functional progression differently according to
gender. Amelia Huang1, A. Harris1, A. Verticchio
Vercellin2, N. Moore1, T. J. Knight1, B. Kaskan1,
C. Jonescu-Cuypers1, G. Eckert3, B. A. Siesky1.
1
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN; 2University Eye
Clinic, IRCCS Policlinico San Matteo, Pavia,
Italy;3Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
2980 — A0329 Longitudinal changes in
macular thickness correlate with changes in
retrobulbar vascular resistance in open-angle
glaucoma patients with diabetes mellitus.
Thai Do1, A. Harris1, A. Verticchio Vercellin2, N.
Moore1, C. Ridenour1, A. Belamkar1, G. Eckert3,
B. A. Siesky1. 1Ophthalmology, Indiana University
School of Medicine, Indianapolis, IN; 2University
Eye Clinic, iRCCS Policlinico San Matteo, Pavia,
Italy; 3Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
2986 — A0335 Retrobulbar blood flow
velocities predict functional progression in openangle glaucoma patients differently according
to age. Alexander Snyder1, A. Harris1, N. Moore1,
A. Verticchio Vercellin2, C. Ridenour1, G. Eckert3,
S. Wentz1, B. A. Siesky1. 1Ophthalmology, Indiana
University School of Medicine, Indianapolis,
IN; 2University Eye Clinic, IRCCS Policlinico
San Matteo, Pavia, Italy; 3Biostatistics, Indiana
University School of Medicine, Indianapolis, IN
*CR
2981 — A0330 Longitudinal changes in
retrobulbar blood flow more strongly correlate
with changes in optic nerve head structure in
open-angle glaucoma patients with diabetes
mellitus. Tyler J. Knight1, A. Harris1, B. A. Siesky1,
N. Moore1, C. Ridenour1, B. Kaskan1, G. Eckert3,
A. Verticchio Vercellin2. 1Ophthalmology, Indiana
University School of Medicine, Indianapolis,
IN; 2University Eye Clinic, IRCCS Policlinico
San Matteo, Pavia, Italy; 3Biostatistics, Indiana
University School of Medicine, Indianapolis, IN
*CR
2987 — A0336 Large choroidal vessel thickness
drives change in choroidal thickness with IOP
following Trabeculectomy. Xuemin Zhang1,
E. Cole2, A. Pillar1, M. Adhi2, N. K. Waheed2,
O. Saeedi1.1Ophthalmology, University of
Maryland School of Medicine, Burtonsville, MD;
2
Ophthalmology, Tufts Medical Center, Boston, MA
2982 — A0331 Retinal blood flow more
strongly correlates with systemic blood pressure
and ocular perfusion pressure in open-angle
glaucoma patients with diabetes mellitus.
Katherine Hutchins1, A. Harris1, N. Moore1, A.
Verticchio Vercellin2, C. Ridenour1, B. Kaskan1,
G. Eckert3, B. A. Siesky1. 1Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN;
2
University Eye Clinic, IRCCS Policlinico San
Matteo, Pavia, IN; 3Biostatistics, Indiana University
School of Medicine, Indianapolis, IN *CR
2983 — A0332 Racial differences in
correlations between optic nerve head
morphology and ocular blood flow in healthy
eyes. Koosha Ramezani, A. Harris, B. A. Siesky, C.
Olinde, D. WuDunn, B. Kaskan, J. Eikenberry, L.
A. Tobe, L. Racette. Department of Ophthalmology,
Eugene and Marilyn Glick Eye Institute,
Indianapolis, IN *CR
2984 — A0333 Retinal arterial vessel crosssectional area more strongly correlates with
structural parameters in open-angle glaucoma
patients of African descent. Brent A. Siesky1, A.
Harris1, A. Verticchio Vercellin2, A. Huang1, T. J.
Knight1, Y. Catoira-Boyle1, G. Eckert3, D. WuDunn1,
N. Moore1. 1Ophthalmology, Indiana University
School of Medicine, Indianapolis, IN; 2University
Eye Clinic, IRCCS Policlinico San Matteo, Pavia,
Italy; 3Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
2988 — A0337 Relationship between oxygen
saturation of the retinal vessels and visual field
defect in glaucoma patients: comparison with
each hemifield. Kazuyuki Hirooka, T. Shimazaki,
Y. Nakano, E. Nitta, K. Ukegawa, S. Sato, A.
Tsujikawa. Ophthalmology, Kagawa Univ Faculty
of Medicine, Kita-gun, Japan
2989 — A0338 Retrobulbar blood flow predicts
functional and structural progression in openangle glaucoma patients with greater body
mass indices. Leslie A. Tobe1, A. Harris1, B. A.
Siesky1, N. Moore1, A. Huang1, C. Ridenour1, Y.
Catoira-Boyle1, G. Eckert2, A. Verticchio Vercellin3.
1
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN; 2Biostatistics, Indiana
University School of Medicine, Indianapolis,
IN;3University Eye Clinic, IRCCS Policlinico San
Matteo, Pavia, Italy *CR
2990 — A0339 Ocular perfusion pressure as
a surrogate for ocular perfusion: mathematical
and statistical methods to interpret clinical data.
Giovanna Guidoboni1, A. Harris2, A. Guglielmi3,
S. Cassani1, B. A. Siesky2. 1Mathematical Sciences,
Indiana University Purdue University Indianapolis,
Indianapolis, IN; 2Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN;
3
Mathematics, Politecnico di Milano, Milano,
Italy*CR
2991 — A0340 Computer-aided ophthalmic
artery waveform analysis in healthy individuals
and glaucoma patients. Lucia Carichino1, G.
Guidoboni1, 2, A. Verticchio Vercellin4, G. Milano4,
C. Cutolo3, C. Tinelli5, A. De Silvestri5, S. Lapin6, 7,
B. A. Siesky2, A. Harris2. 1Mathematical Sciences,
Indiana University Purdue University Indianapolis,
Indianapolis, IN; 2Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN;
3
University Eye Clinic, DiNOGMI, University
of Genoa, Genoa, Italy; 4University Eye Clinic,
Foundation IRCCS, Policlinico San Matteo, Pavia,
Italy; 5Clinical Epidemiology and Biometric Unit,
Foundation IRCCS, Policlinico San Matteo, Pavia,
Italy; 6Washington State University, Pullman,
WA; 7Kazan Federal University, Kazan, Russian
Federation *CR
2992 — A0341 The Effect of Systemic
Hyperoxia on Optic Nerve Head Blood Flow
in Glaucoma. Naoki Kiyota, Y. Shiga, M. Sato, S.
Maekwa, K. Omodaka, K. Maruyama, H. Takahashi,
H. Kunikata, T. Nakazawa. Ophthalmology, Tohoku
university school of medicine, Sendai-shi, Japan
2993 — A0342 Ocular neurovascular changes
during head-down posture predict future retinal
nerve fiber layer loss in glaucoma suspects.
Giacinto Triolo1, 2, W. J. Feuer1, P. F. Monsalve1,
L. E. Vazquez1, J. J. McSoley1, L. Ventura1, V.
Porciatti1. 1Ophthalmology, Bascom Palmer Eye
Institute, University of Miami Miller School of
Medicine, Miami, FL; 2Ophthalmology, University
Scientific Institute San Raffaele, Milan, Italy
2994 — A0343 Choroidal Volume Change with
Acute Intraocular Pressure Elevation in Primary
Angle-Closure Suspects. Ya Xing Wang1, R. Jiang1,
H. Shi2, L. Xu1, J. B. Jonas3. 1Beijing Institute of
Ophthalmology, Beijing Tongren Hospital, Beijing,
China; 2College of Biomedical Engineering, Capital
Medical University, Beijin, China; 3Department of
Ophthalmology, Medical Faculty Mannheim of the
Ruprecht-Karls-University, Manheim, Germany
2995 — A0344 Evaluation of retinal blood flow
before and after topical tafluprost treatment
in glaucoma patients using adaptive optics
scanning laser ophthalmoscopy. Yuto Iida, T.
Akagi, H. Nakanishi, H. Ikeda, S. Morooka, K.
Suda, T. Hasegawa, H. Yamada, M. Yoshikawa, A.
Uji, N. Yoshimura. Department of Ophthalmology
and Visual Sciences, Kyoto University, Kyoto City,
Japan *CR
2996 — A0345 Assessment of the ophthalmic
artery and the superior ophtalmic vein blood
flow in glaucoma patients with Phase contrast
MRI, preliminary results. Veronique Promelle2, 1,
S. Milazzo2, 1, G. Pagé3, 1, J. Daouk3, 1, R.
Bouzerar3, 1, O. Balédent3, 1. 1Université de Picardie
Jules Verne, Amiens, France; 2Ophthalmology,
University Hospital of Amiens, Amiens, France;
3
Medical Image Processing Unit, University
Hospital of Amiens, Amiens, France
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
214
Tuesday – Posters – 2997 – 3019
2997 — A0346 The effect of low cerebrospinal
fluid pressure on optic disc and macula perfusion
in monkey model using optical coherence
tomography angiography. Ningli Wang. Dept
of Ophthalmology, Beijing Tongren Eye Center,
Beijing, China
2998 — A0347 Vasodilating effect of Ripasudil
Hydrochloride Hydrate on isolated rabbit
posterior ciliary arteries. Takako Sugimoto,
H. Chuman, N. Nao-i. Opthalmology, Miyazaki
University, Miyazaki, Japan
2999 — A0348 The effect of chronic
hypertension on retinal autoregulation in rats.
Anna K. van Koeverden, Z. He, C. T. Nguyen, A. J.
Vingrys, B. V. Bui. Optometry and Vision Sciences,
The University of Melbourne, Parkville, VIC,
Australia
3001 — A0350 The effect of ocular perfusion
pressure lowering on vessel diameter and
astrocyte calcium in the rat retina. Grant Cull1,
L. Wang1, H. Li3, B. V. Bui2. 1Ophthalmology,
Devers Eye Institute, Portland, OR; 2Department
of Optometry and Vision Sciences, The University
of Melbourne, Melbourne, VIC, Australia;
3
Department of Ophthalmology, Shanghai Tenth
People’s Hospital, Shanghai, China
3002 — A0351 Localization of AT1 and MAS
receptors on porcine retinal arteries. Arnar
Ossur Hardarson1, S. Ingthorsson2, T. Eysteinsson1.
1
Physiology, University of Iceland, Reykjavik,
Iceland; 2Stem Cell Research Unit, University of
Iceland, Reykjavik, Iceland
Exhibit/Poster Hall A0352-A0394
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Glaucoma / Retina
314 Glaucoma Clinical studies /
Pharmacology
Moderators: Kuldev Singh and Shan C. Lin
3003 — A0352 Review of anterior segment
neovascularization cases treated with intravitreal
vascular endothelial growth factor inhibitors.
Maria Velazquez-Lamela, N. Bhagat, M. A. Zarbin,
A. S. Khouri. Ophthalmology, Rutgers-NJMS,
New York, NY
3005 — A0354 Autophagy and Mitochondrial
Dysfunction in Tenon Fibroblasts from
Exfoliation Glaucoma Patients. J Mario Wolosin1,
A. Want1, S. Gillespie1, Z. Wang1, R. Ritch2, A.
M. Bernstein1.1Ophthalmology, Icahn School
of Medicine, New York, NY; 2Visual Sciences,
NYEER, New York, NY
3006 — A0355 Additive ocular hypotensive
effects of Bimatoprost Sustained-Release
intracameral implant on potent topical therapy
in monkeys. Susan S. Lee, A. S. Almazan, H. Li, A.
N. Ghebremeskel, P. M. Hughes, M. R. Robinson, J.
A. Burke. Allergan, Inc., Irvine, CA *CR
3007 — A0356 Assessing Concordance of
Aqueous Humor Flow and IOP Changes After
Timolol. Sayoko E. Moroi1, M. G. Trese1, D. Reed1,
M. Renner1, V. Gulati2, A. Kazemi3, J. McLaren3,
D. Musch1, C. Toris4, A. J. Sit3. 1Ophthalmology,
Univ of Michigan-Kellogg Eye Ctr, Ann Arbor,
MI; 2Ophthalmology, UNMC, Omaha, NE;
3
Ophthalmology, Mayo Clinic, Rochester, MN;
4
Ophthalmology, Case Western Reserve University,
Cleveland, OH *CR, f
3008 — A0357 Elevated IOP primarily
induces responses in the vascular cells in animal
models of glaucoma in vivo and in vitro. Verena
Prokosch2, K. Brockhaus1, F. Anders2, M. Meyer
zu Horste1, N. Pfeiffer2, S. Thanos1. 1Institute for
Experimental Ophthalmology, University Hospital
Muenster, Muenster, Germany; 2Medical University
Center Mainz, Mainz, Germany
3009 — A0358 Priming of the NLRP3
inflammasome in optic nerve head astrocytes by
mechanical strain and stimulation of the P2X7
receptor. Claire H. Mitchell, F. Albalawi, J. Lim, W.
Lu. University of Pennsylvania, Philadelphia, PA
3010 — A0359 The Soluble Guanylate Cyclase
Stimulator IWP-953 Increases Conventional
Outflow Facility in Mouse Eyes. Pei Ge1, I.
Navarro2, M. Kessler1, S. Bernier1, N. Perl1, R.
Sarno1, J. Masferrer1, G. Hannig1, W. D. Stamer2.
1
Ironwood Pharmaceuticals, Cambridge, MA;
2
Ophthalmology, Duke University, Durham, NC *CR
3011 — A0360 Altered interactions of
concomitant administrations of ROCK inhibitor
and parasympathetic agonist in mouse IOP and
outflow dynamics. Reiko Yamagishi1, M. Honjo1, Y.
Aoyama1, T. Uchida1, 2, M. Aihara1. 1Ophthalmology,
University of Tokyo, Bunkyo-ku, Japan; 2Senju
Pharmaceutical Co., Ltd., Kobe, Japan *CR
3012 — A0361 The effect of TRPV4 in Primary
Cilia Signaling. Na Luo1, X. Hu1, M. Qi1, Y. Sun1, 2.
1
Ophthalmology, Medicine school of Indiana
University, Indianapolis, IN; 2Glick Eye Institute,
Indianapolis, IN
3013 — A0362 Mechanical strain modulates
TRPV4-dependent cytoskeletal reorganization
in the trabecular meshwork. David Krizaj1, 2, M.
Lakk1, T. T. Phuong1. 1Ophthalmology & Visual
Sciences, Univ of Utah School of Med, Salt Lake
City, UT; 2Neurobiology & Anatomy, University of
Utah, Salt Lake City, UT *CR
3014 — A0363 Trabecular meshwork Wnt
signaling pathway is altered by non-Pigmented
ciliary epithelium derived exosomes. Natalie
Lerner. Clinical Pharmacology, Ben-Gurion
University of the Negev, Beer-Sheva, Israel
3015 — A0364 The multiple hit theory of
primary open angle glaucoma. Michael Giovingo1,
K. Green2, K. Carey2, I. Bielskus2, M. Patel2, L.
R. Pasquale3, T. Patrianakos1, J. R. Samples4, E.
Martin1, P. A. Knepper2, 5. 1Ophthalmology, John H.
Stroger, Jr. Hospital of Cook County, Chicago, IL;
2
Ophthalmology and Visual Sciences, University of
Illinois at Chicago, Chicago, IL; 3Ophthalmology,
Massachusetts Eye and Ear, Chicago, IL;
4
Vista University, Parker, CO; 5Ophthalmology,
Northwestern University, Chicago, IL *CR
3016 — A0365 Source of Optic Nerve
Metabolic Vulnerability in DBA/2J Model of
Glaucoma. Denise M. Inman1, P. G. Palmer2.
1
Pharmaceutical Sciences, Northeast Ohio Medical
University, Rootstown, OH;2Bio-Med Science
Academy, Rootstown, OH
3017 — A0366 Digoxin derivatives with
selectivity for the α2β3 isoform of Na,K-ATPase
potently reduce intraocular pressure. Dan
Heller1, A. Marcovich4, A. Katz2, D. M. Tal2, M.
Habeck2, E. Ben Zeev3, B. Rabah4, Y. Barkana1,
S. J. Karlish2. 1Department of ophthalmology,
Assaf Harofe medical center, Rehovot, Israel;
2
Deptartment of Biological Chemistry, Weizmann
Institute of Science, Rehovot, Israel; 3Israel
National Centre for Personalized Medicine,
Weizmann Institute of Science, Rehovot, Israel;
4
Department of ophthalmology, Kaplan medical
center, Rehovot, Israel *CR
3018 — A0367 Ocular hypotensive properties
of water soluble prodrugs of the ATP sensitive
potassium channel opener cromakalim. Uttio
Roy Chowdhury1, K. B. Viker1, P. I. Dosa2, M.
P. Fautsch1.1Ophthalmology, Mayo Clinic,
Rochester, MN; 2Medicinal Chemistry, Institute
for Therapeutics Discovery and Development,
University of Minnesota, Minneapolis, MN
3019 — A0368 Long-term latanoprost release
from a subconjunctival drug delivery system.
Franziska Kopp1, T. Eickner1, K. Falke2, R.
Guthoff1, 2. 1Institute for Biomedical Engineering,
University Medical Center Rostock, Rostock,
Germany; 2Department of Ophthalmology, University
Medical Center Rostock, Rostock, Germany
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
215
Tuesday Posters
8:30 am – 10:15 am
3000 — A0349 The longitudinal changes of
optic nerve head blood flow of the normal rats
using laser speckle flowgraphy. yasushi wada.
Ophthalmology, Ophthalmology and Visual
Science, Kanazawa University Graduate School of
Medical Science, Kanazawa, Japan., Kanazawa city,
Japan; Ophthalmology, Ophthalmology, National
Hospital Organization Kanazawa Medical Center,
Kanazawa, Japan., Kanazawa, Japan., Japan
3004 — A0353 Effects of Atorvastatin
on Aqueous Humor Outflow and Porcine
Trabecular Meshwork Cells. Lin Cong, J. Zhang,
S. Fu, Y. Zhang, Y. Zhang. Huashan Hospital of
Fudan University, Shanghai, China
3020 – 3034 – Tuesday – Posters
3020 — A0369 Efficacy and safety of switching
prostaglandin analogue-monotherapy to
tafluprost/timolol fixed-combination. Kazuyoshi
Kitamura, T. Chiba, F. Mabuchi, K. Kashiwagi.
Biomedical Enginnering, University of Yamanashi,
Chuo, Japan *CR, f
3021 — A0370 Design and Development of
ENV515 Intraocular Applicator for Intracameral
Injections of ENV515 Glaucoma Extended
Release (XR) Therapy. Tomas Navratil1, J.
Delgado2, A. Garcia1, G. Willard2, A. Corson2, R.
S. Verhoeven1, L. Trevino1, R. Schiffman1. 1Envisia
Therapeutics, Research Triangle Park, NC; 2EGGilero, Durham, NC *CR, f
Tuesday Posters
8:30 am – 10:15 am
3022 — A0371 Intracameral Administration
of a Sustained Release Bimatoprost Implant
Efficiently Delivers Bimatoprost to Target Tissue
Reducing Risk of Topical Prostaglandin AnalogAssociated Adverse Events. Jennifer Seal1, S.
Perera2, M. Coote3, M. R. Robinson1, P. M. Hughes1,
A. N. Ghebremeskel1, J. A. Burke1, M. Attar1.
1
Allergan plc, Irvine, CA; 2Singapore National
Eye Centre, Singapore, Singapore;3Melbourne Eye
Specialists, Melbourne, VIC, Australia *CR, f
3023 — A0372 Results of Phase IIB SYLTAG
clinical trial with bamosiran in patients with
glaucoma. Victoria Gonzalez1, J. MorenoMontanes2, 9, M. Oll3, K. N. Sall4, K. Palumaa5,
H. Dubiner6, K. Turman7, F. Muñoz-Negrete8, 9, V.
Ruz1, A. Jimenez1. 1Ophthalmology, Sylentis, Tres
Cantos Madrid, Spain; 2Ophthalmology, Clinical
Universidad Navarra, Navarra, Spain; 3Tartu
olikooli kliinikum, Tartu, Estonia; 4Sall Research
medical center, Artesia, CA; 5East-Tallinn Central
Hospital Eye Clinic, Tallinn, Estonia; 6Clayton eye
center, Morrow, GA; 7Eye Clinic Dr. Krista Turman,
Talliin, Estonia; 8Hospital Ramón y Cajal, Madrid,
Spain; 9Oftared, Pamplona, Spain *CR, f
3024 — A0373 A Phase 1 Pharmacokinetic
Study to Assess the Relative Systemic
Bimatoprost Exposure Following Placement of
a Novel Bimatoprost Ocular Insert in Healthy
Adults. Gary Walker1, J. E. Patrick4, K. N.
Sall2, W. G. Kramer3, R. L. Phelps5, S. Soni1, M.
Gee-Shihabi6, C. P. Semba1. 1Clinical Research,
ForSight VISION 5, Menlo Park, CA; 2Sall Eye
Research Medical Center, Artesia, CA; 3Kramer
Consulting, LLC, North Potomac, MD; 4Patrick’s
Pharmaceutical Consulting, LLC, Aiken, SC;
5
PharmAdvance Consulting, Inc, Sequim, WA;
6
Intertek Pharmaceutical Services, San Diego, CA
*CR, f
3026 — A0375 Patient satisfaction related to
tolerance when treated with preservative-free
latanoprost; results from the PASSY survey
in six European countries. Hans G. Lemij1, I.
Stalmans2, C. Erb3, F. Munoz4. 1Ophthalmology,
Rotterdam Eye Hosp (Oogziekenhuis Rotterdam),
Rotterdam, Netherlands; 2University Hospitals
Leuven, Leuven, Belgium; 3Augenklinik am
Wittenbergplatz, Berlin, Germany; 4Ramon y Cajal
Hospital, Madrid, Spain *CR
3027 — A0376 Efficacy of 4% Hydroquinone
in Japanese Glaucoma Patients with Topical
Prostaglandin Analogue-induced Eyelid
Pigmentation: A Randomized, EvaluatorsBlinded, Left-Right Comparison Study. Koichi
Ono1, R. Ueki2, T. Kimura3, K. Akimoto4, R.
Umeya1, K. Akashi2, S. Ohgiya2, M. Kawashima5.
1
Department of Ophthalmology, Juntendo
Tokyo-Koto Geriatric Medical Center, Koto-ku,
Japan;2Department of Dermatology, Juntendo
Tokyo-Koto Geriatric Medical Center, KotoKu, Japan; 3Department of Ophthalmology,
Ueno Eye Clinic, Taito-ku, Japan; 4Department
of Dermatology, Skin Care Ueno Clinic, Taitoku, Japan; 5Department of Dermatology, Tokyo
Women’s Medical University, Shinjuku-ku, Japan f
3028 — A0377 The In Vivo Effect of
Preservative Benzalkonium Chloride on Corneal
Immune Cells and Clinical Signs in Glaucoma
Therapy. Yureeda Qazi1, A. Cruzat3, 1, B. M.
Cavalcanti1, C. Colon1, D. Witkin1, T. C. Chen4,
P. Hamrah2, 1. 1Ocular Surface Imaging Center,
Massachusetts Eye and Ear Infirmary, Boston, MA;
2
New England Eye Center, Tufts University, Boston,
MA; 3Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA; 4Glaucoma, Massachusetts
Eye and Ear Infirmary, Boston, MA *CR, f
3029 — A0378 A phase I First-In Human
single ascending dose study of ISTH0036, a
potent and selective antisense oligonucleotide
targeting transforming growth factor beta 2
(TGF-β2) for the treatment of primary openangle glaucoma. Bogomil Voykov1, K. Lorenz2, C.
Schuart3, P. Richter1, B. Wilhelm4, L. Choritz3, V.
Prokosch-Willing2, P. Fettes5, E. Leo5, N. Pfeiffer2.
1
Centre for Ophthalmology, University Hospital
Tuebingen, Tuebingen, Germany; 2Ophthalmology,
University Medical Center Mainz, Mainz, Germany;
3
Ophthalmology, Otto-von-Guericke-University,
Magdeburg, Germany; 4STZ Eyetrial at the Centre
for Ophthalmology, University Hospital Tuebingen,
Tuebingen, Germany; 5Isarna Therapeutics GmbH,
Munich, Germany *CR, f
3025 — A0374 Completed 28-Day and Ongoing
12-Month Safety and Efficacy Evaluation of
ENV515 (travoprost) Intracameral Implant in
Phase 2 Study. Thomas R. Walters1, T. Navratil2, S.
Pittman2, V. Conley2, L. Trevino2, B. E. Silverstein3,
M. Depenbusch4, S. L. Mansberger5, R. Schiffman2.
1
Texan Eye/Keystone Research, Austin, TX;
2
Envisia Therapeutics, Research Triangle Park, NC;
3
Shasta Eye Medical Group, Redding, CA; 4Arizona
Eye Center, Phoenix, AZ; 5Devers Eye Institute,
Portland, OR *CR, f
3030 — A0379 Long-term Efficacy and
Safety of Latanoprostene Bunod 0.024% for
Intraocular Pressure Lowering in Patients with
Open-Angle Glaucoma or Ocular Hypertension:
APOLLO and LUNAR Studies. Jason L. Vittitow1,
J. M. Liebmann2, P. L. Kaufman3, F. A. Medeiros4,
K. R. Martin5, R. N. Weinreb6. 1Clinical Affairs,
Bausch + Lomb, Bridgewater, NJ; 2Department of
Ophthalmology, Edward S. Harkness Eye Institute,
Columbia University Medical Center, New York,
NY; 3Department of Ophthalmology & Visual
Sciences, Univ of Wisconsin Sch of Med & Public
Hlth, Madison, WI; 4Hamilton Glaucoma Center,
Shiley Eye Institute, University of California,
San Diego, La Jolla, CA; 5Eye Department,
Addenbrooke’s Hospital and Cambridge NIHR
Biomedical Research Centre, Cambridge, United
Kingdom; 6Hamilton Glaucoma Center, Shiley
Eye Institute and Department of Ophthalmology,
University of California, San Diego, La Jolla, CA
*CR, f
3031 — A0380 IOP-lowering effects of NCX
667 in combination with travoprost in ocular
normotensive and transient hypertensive
rabbits. Elena Bastia1, E. Masini2, M. Durante2,
M. Bergamini3, E. Ongini1, F. Impagnatiello1.
1
Nicox Research Institute, Bresso (MI), Italy;
2
NEUROFARBA, Section of Pharmacology and
Toxicology, Firenze, Italy; 3Nicox Ophthalmics Inc.,
Fort Worth, TX *CR
3032 — A0381 Intraocular pressurelowering efficacy and safety of 0.4% ripasudil.
Hideki Mochizuki2, 1, K. Noma2, Y. Kiuchi1.
1
Ophthalmology, Hiroshima University, Hiroshima,
Japan; 2Private practice, Hiroshima, Japan
3033 — A0382 Specific clinical features of
intraocular pressure-lowering effect in ripasudil
(K-115): insights from 52-week phase 3 study.
Hidenobu Tanihara1, T. Inoue1, T. Yamamoto5, Y.
Kuwayama4, H. Abe7, A. Fukushima2, H. Suganami3,
M. Araie6. 1Department of Ophthalmology,
Faculty of Life Sciences, Kumamoto University,
Kumamoto, Japan; 2Department of Ophthalmology
and Visual Science, Kochi Medical School, Kochi,
Japan; 3Kowa Company, Ltd, Nagoya, Japan;
4
Fukushima Eye Clinic, Osaka, Japan; 5Department
of Ophthalmology and Visual Science, Gifu
University Graduate School of Medicine, Gifu,
Japan; 6Kanto Central Hospital of the Mutual Aid
Association of Public School Teachers, Tokyo,
Japan; 7Niigata University of Health and Welfare,
Niigata, Japan *CR, f
3034 — A0383 Intraocular pressure-lowering
and ocular exposure of NCX 1653, a novel
nitric oxide-donating travoprost in models of
ocular hypertension and glaucoma. Francesco
Impagnatiello1, L. Storoni1, S. Brambilla1, E.
Masini2, C. Lanzi2, C. B. Toris3, M. Bergamini4,
E. Ongini1, E. Bastia1. 1Nicox Research Institute,
Bresso (MI), Italy; 2NEUROFARBA, Section
of Pharmacology and Toxicology, Firenze,
Italy;3University of Nebraska Medical Center,
Omaha, NE; 4Nicox Ophthalmics Inc., Fort Worth,
TX *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
216
Tuesday – Posters – 3035 – 3057
3035 — A0384 Efficacy of Latanoprostene
Bunod 0.024% vs. Timolol Maleate 0.5% for
Intraocular Pressure Lowering in Patients with
Open-Angle Glaucoma or Ocular Hypertension:
the LUNAR Study.James H. Peace1, F. A.
Medeiros2, K. R. Martin3, J. L. Vittitow4, R. N.
Weinreb5. 1United Medical Research Institute,
Inglewood, CA; 2Hamilton Glaucoma Center, Shiley
Eye Institute, University of California, San Diego,
La Jolla, CA; 3Eye Department, Addenbrooke’s
Hospital and Cambridge NIHR Biomedical
Research Centre, Cambridge, United Kingdom;
4
Clinical Affairs, Bausch + Lomb, Bridgewater, NJ;
5
Hamilton Glaucoma Center, Shiley Eye Institute
and Department of Ophthalmology, University of
California, San Diego, La Jolla, CA *CR, f
3037 — A0386 Long-term Safety and
Intraocular Pressure Lowering Efficacy of
Latanoprostene Bunod 0.024% in Japanese
Subjects with Open-Angle Glaucoma or Ocular
Hypertension: the JUPITER Study. Kazuhide
Kawase1, J. L. Vittitow2, T. Yamamoto1, M. Araie3.
1
Gifu University Hospital, Gifu, Japan; 2Clinical
Affairs, Bausch + Lomb, Bridgewater, NJ; 3Kanto
Central Hospital of The Mutual Aid Association of
Public School Teachers, Tokyo, Japan *CR, f
3038 — A0387 Evidence for GPR18 role in
diurnal regulation of intraocular pressure.
Alex Straiker, O. oehler, L. Daily, E. leishman, H.
Bradshaw. Indiana University, Bloomington, IN
3039 — A0388 Intravitreal Aflibercept or
Ranibizumab for Rubeosis Iridis - 1 year follow
up. Joao J. Nassaralla1, J. J. Nassaralla3, A. A.
Nassaralla2. 1Ophthalmology, Instituto de Olhos de
Goiania and UnB, Goiania, Brazil; 2Ophthalmology,
FMSLM, Campinas, Brazil; 3Ophthalmolgy, UFG,
Goiania, Brazil f
3040 — A0389 Stability study of Bamosiran
(a siRNA compound) in ophthalmic solution in
different containers. Veronica Ruz, V. Gonzalez,
A. Jimenez, L. Company, Y. Ruiz, C. Astrain.
Ophthalmology, Sylentis, Madrid, Spain *CR
3049 — B0004 Epidemiology Of Ocular
Injuries In Major Trauma-The Bronx
Experience. Lediana Goduni1, D. Poulsen1, 3, J.
Mbekeani1, 2. 1Medicine, Albert Einstein College of
Medicine, Bronx, NY; 2Surgery, North Bronx Health
Network, Bronx, NY; 3Ophthalmology and Visual
Sciences, Montefiore Medical Center, Bronx, NY
3043 — A0392 A Multicenter Study Assessing
Inter-Examiner Agreement of Gonioscopic
Shaffer Grading in Patients with Open-Angle
Glaucoma and/or Ocular Hypertension. Reihab
Ahmed, B. Khan, M. Chen, M. R. Robinson, S. S.
Lee. Allergan plc, Irvine, CA *CR, f
3050 — B0005 Characterisitics Of Ocular
Trauma In Elderly Patients Of The Bronx.
Isaac Chocron1, 3, D. Poulsen1, 3, L. Goduni1, J.
Mbekeani1, 2. 1Albert Einstein College of Medicine,
Bronx, NY; 2Surgery, North Bronx Health Network,
Bronx, NY; 3Opthalmology & Visual Sciences,
Montefiore Medical Center, Bronx, NY
3044 — A0393 Does Knowledge of the Risk
Factors of Glaucoma Impact Adherence in
patients of African descent? Kadé Diallo4,
S. Bigatti2, B. Sutton3, J. Torbit3, L. Racette1.
1
Ophthalmology-Glick Eye Institute, Indiana
University School of Medicine, Indianapolis, IN;
2
Indiana University Fairbanks School of Public
Health, Indianapolis, IN; 3Indianapolis Eye Care
Center, Indiana University School of Optometry,
Indianapolis, IN;4Ophthalmology, Glick Eye
Insttitute, Indiana University School of Medicine,
Indianapolis, IN
3045 — A0394 Age-related changes in aqueous
humor dynamics in healthy Chinese adults.
tao guo. ophthalmology, Shanghai ninth people’s
hospital,Shanghai JiaoTong University School
of Medicine, ShangHai, China; ophthalmology,
Shanghai Tenth people’s hospital, ShangHai, China
Exhibit/Poster Hall B0001-B0013
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
315 Trauma: Effects and Outcomes
Moderator: Roomasa Channa
3046 — B0001 Orbital fracture management
and race. Kalla A. Gervasio, A. Y. Wu. Icahn School
of Medicine at Mount Sinai, New York, NY
3047 — B0002 A Review of Orbital Fractures
at a Level 1 Trauma Center - Do all visually
asymptomatic patients require emergent
ophthalmological evaluation? Mehul Patel.
Ophthalmology, Howard University, Arlington, VA
3048 — B0003 Aetiology and injury patterns
of orbital fractures across age groups in a
tertiary centre in Singapore: A retrospective
study of 333 patients. Kailing Yong1, 2, I. loh3, S.
shen1, 2. 1Singapore National Eye Centre, Singapore,
Singapore; 2Singapore Eye Research Institute,
Singapore, Singapore; 3ENT, Changi General
Hospital, Singapore, Singapore
3041 — A0390 Changes in ocular hypotensive
effect of Rho-associated protein kinase inhibitor,
Ripasudil, with pilocarpine and timolol in rabbit
eye. Yu Mizuno, Y. Kiuchi. Hiroshima University,
Hiroshima, Japan
3051 — B0006 Epidemiology of Outpatient
Ocular Trauma - The Bronx Experience.
David Poulsen1, 2, L. Goduni1, J. Mbekeani1, 3.
1
Ophthalmology, Albert Einstein College of
Medicine, Bronx, NY;2Ophthalmology, Montefiore
Medical Center, Bronx, NY; 3Surgery, North Bronx
Health Network, Bronx, NY
3052 — B0007 Endophthalmitis After Open
Globe Repair. Xintong Li, M. A. Zarbin, P. D.
Langer, N. Bhagat. Ophthalmology, Rutgers New
Jersey Medical School, Newark, NJ
3053 — B0008 The Inland Empire Eye
Emergency Epidemiology Study. Kimberly M.
Chan, C. G. Maddux, M. Rauser. Ophthalmology,
Loma Linda University, Loma Linda, CA
3054 — B0009 Outcomes of Post-traumatic
Glaucoma in Assault Injuries. Kelly Lee, C.
Seery, A. Yadgarov, A. S. Khouri. Institute of
Ophthalmology & Visual Sciences, Rutgers New
Jersey Medical School, Newark, NJ
3055 — B0010 Anterior chamber collapse
syndrome is caused by presumed early life
trauma in canines and felines. Gillian C. Shaw,
R. R. Dubielzig, L. B. Teixeira. Comparative
Ocular Pathology Laboratory, Department of
Pathobiological Sciences, University of Wisconsin,
Madison, WI
3056 — B0011 Severe acute ocular chemical
injuries - retrospective clinical audit of 38
consecutive new admissions in a tertiary hospital
in the UK. Borja Salvador-Culla1, J. Hogg2, A.
Okonkwo2, J. Mulroy1, G. S. Figueiredo2, 3, F. C.
Figueiredo2, 3. 1Ophthalmology, Royal Victoria
Infirmary, Newcastle Upon Tyne, Boston, MA;
2
Ophthalmology, Royal Victoria Infirmary,
Newcastle University, Newcastle Upon Tyne,
United Kingdom; 3Institute of Genetic Medicine,
Newcastle University, Newcastle upon Tyne,
United Kingdom
3057 — B0012 Knowledge, Attitudes, and
Practices of Eye Safety Among Skilled Manual
Workers. Rohini Rao, M. Gardiner, M. Hymowitz.
Ophthalmology, Massachusetts Eye And Ear
Infirmary, Boston, MA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
217
Tuesday Posters
8:30 am – 10:15 am
3036 — A0385 Integrated Efficacy of
Latanoprostene Bunod 0.024% vs. Timolol
Maleate 0.5% for Intraocular Pressure Lowering
in Patients with Open-Angle Glaucoma or
Ocular Hypertension: APOLLO and LUNAR
Studies. Paul L. Kaufman1, J. M. Liebmann2,
J. L. Vittitow3, R. N. Weinreb4. 1Department of
Ophthalmology & Visual Sciences, Univ of
Wisconsin Sch of Med & Public Hlth, Madison,
WI;2Department of Ophthalmology, Edward S.
Harkness Eye Institute, Columbia University
Medical Center, New York, NY; 3Clinical Affairs,
Bausch + Lomb, Bridgewater, NJ; 4Hamilton
Glaucoma Center, Shiley Eye Institute and
Department of Ophthalmology, University of
California, San Diego, La Jolla, CA *CR, f
3042 — A0391 Effect of Brimonidine 0.15%
versus Pilocarpine 2% on Angle configuration
and Miosis in Eyes with Angle Closure. David
Chen1, 2, B. Mani1, 2, S. Perera1, 2, R. Husain1, 2,
T. Aung1, 2.1Singapore Eye Research Institute,
Singapore, Singapore; 2Singapore National Eye
Centre, Singapore, Singapore *CR, f
3058 – 3077 – Tuesday – Posters
3058 — B0013 Review of Malpractice
Litigation in Ocular Trauma over Eight Decades.
Sherveen S. Salek1, S. B. Engelhard2, C. Shah2, A.
Sim2, A. Reddy1. 1Ophthalmology, Johns Hopkins
Hospital - Wilmer Eye Institute, Baltimore, MD;
2
University of Virginia, Charlottesville, VA
Exhibit/Poster Hall B0046-B0064
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Lens
316 Lens development and fiber
cell biology
Moderator: Salil A. Lachke
Tuesday Posters
8:30 am – 10:15 am
3059 — B0046 Lentoid bodies derived from
human induced pluripotent stem cells model the
human lens genesis in vitro. Qiuli FU1, Z. Qin1,
J. Ji2, K. Yao1, 2. 1the 2nd Affiliated Hospital of
Zhejiang University, Hangzhou, China; 2Medical
School of Zhejiang University, Hangzhou, China
3060 — B0047 A 3D Lens Cell Culture
Platform to Mimic the Developing Lens. Eddie
Wang, D. Wang, A. Geng, A. Maniar, X. Gong.
Optometry, University of California, Berkeley,
Berkeley, CA
3061 — B0048 Identification of abnormally
expressed miRNAs in Tdrd7 null mouse lens.
Deepti Anand1, C. E. Barnum1, S. A. Lachke1, 2.
1
Department of Biological Sciences, University of
Delaware, Newark, DE; 2Center for Bioinformatics
and Computational Biology, University of
Delaware, Newark, DE
3062 — B0049 Requirements for cellular folate
during lens development. Maria Muccioli, T. F.
Plageman. College of Optometry, The Ohio State
University, Logan, OH
3063 — B0050 Identification of a new RNA
binding protein Rbm24 linked to anophthalmia,
microphthalmia and lens defects. Soma Dash1, S.
A. Lachke1, 2. 1Department of Biological Sciences,
University of Delaware, Newark, DE; 2Center
for Bioinformatics and Computational Biology,
University of Delaware, Newark, DE
3064 — B0051 On cluster sizes during lens
growth in the mouse. Hrvoje Sikic1, 2, S. Bassnett1.
1
Ophthalmology, Washington University in
St.Louis, St. Louis, MO; 2Mathematics, University
of Zagreb, Zagreb, Croatia
3065 — B0052 Postnatal human lens growth:
finding the relationship between dimensions and
weight. Ashik Mohamed1, 2, R. C. Augusteyn2, 3,
H. A. Durkee4, V. S. Sangwan1, 3, J. A. Parel3, 4.
1
Prof. Brien Holden Eye Research Centre, L V
Prasad Eye Institute, Hyderabad, India; 2School of
Optometry and Vision Science, The University of
New South Wales, Sydney, NSW, Australia; 3Vision
Cooperative Research Centre, Brien Holden Vision
Institute, Sydney, NSW, Australia; 4Ophthalmic
Biophysics Center, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL
3066 — B0053 Automatic quantification
of fluorescence signal in rat lens epithelium.
Nooshin Talebizadeh1, Z. Yu1, N. Z. Hagström2,
C. Wählby2, P. G. Soderberg1. 1Neuroscience
department, Uppsala University, Uppsala, Sweden;
2
Department of Information Technology, Uppsala
University, Uppsala, Sweden
3067 — B0054 The role of fibrillin-1 in ciliary
zonule synthesis and lens growth. Wendell Jones,
S. Bassnett. Biomedical Sciences, Washington
University, St.Louis, MO
3068 — B0055 RanGAP1, the most
Prominently SUMOylated Lens Proteins
Regulates Cell Cycle in Lens. David W. Li1, 2, W.
Ji1, X. Hu1, L. Gong2, Z. Huang1, L. Wang2, 1, Y.
Liu2, Q. Nguyen1. 1University of Nebraska Medical
Center, Omaha, NE; 2Zhongshan Ophthalmic
Center, Sun Yat-sen University, Guangzhou, China
3069 — B0056 Imaging the glutathione redox
potential in the intact lens. Miduturu Srinivas1,
J. Gao1, R. Mathias2, N. SLAVI1. 1Biological and
Vision Sciences, SUNY College of Optometry,
New York, NY;2Physiology, SUNY Stony Brook,
Stony Brook, NY
3070 — B0057 Cell-Cell Adhesion Mediated
by the Second Extracellular Domain of
Connexin 50 Promotes Lens Epithelial-Fiber
Cell Differentiation. Jean X. Jiang, Z. Hu, W. Shi,
S. Gu. Biochemistry, University of Texas Health
Science Center, San Antonio, TX
3071 — B0058 Alpha N-catenin, a Neuronal
Subtype Catenin Exhibits Fiber Cell Specific
Distribution; Regulation of the Alpha N-catenin:
N-Cadherin Interaction by Periaxin in Mouse
Lens. Rupalatha Maddala1, J. Qiu1, R. Pratheepa
Kumari1, V. Rao2. 1Ophthalmology, Duke University
Medical Center, Durham, NC; 2Ophthalmology &
Pharmacology, Duke University Medical Center,
Durham, NC
3073 — B0060 Tropomodulin 1 regulation
of actin is required for the formation of large
paddle protrusions between mature lens fiber
cells. Velia M. Fowler1, C. Cheng1, R. B. Nowak1,
S. K. Biswas2, W. Lo2, P. G. FitzGerald3. 1Cell and
Molecular Biology, The Scripps Research Institute,
La Jolla, CA; 2Department of Neurobiology,
Morehouse School of Medicine, Atlanta, GA;
3
Department of Cell Biology and Human Anatomy,
University of California, Davis, CA
3074 — B0061 The interaction of BFSP1 and
its proteolytically derived fragments with cell
membranes. Roy A. Quinlan1, 5, A. Tapodi2, D.
Clemens4, K. Nemeth-Cahalan3, I. Vorontsova3,
P. Jakus2, C. Cawood1, M. Jarrin1, J. E. Hall3.
1
School of Biological and Biomedical Sciences,
Biophysical Sciences Inst, Durham Univ, Durham,
United Kingdom; 2Department of Biochemistry and
Medical Chemistry, Pecs, Hungary;3Physiology and
Biophysics, UC Irvine, Irvine, CA; 4Life Sciences
Addition, UC Berkeley, Berkeley, CA; 5Biophysical
Sciences Institute, UNiversity of Durham, Durham,
United Kingdom *CR
3075 — B0062 Proteomic and
Immunohistochemical Characterization of Lens
Fiber Cell Vesicles. Romell Gletten1, Z. Wang1, K.
Walker2, A. C. Grey3, P. J. Donaldson3, K. L. Schey1.
1
Biochemistry, Vanderbilt University, Nashville,
TN; 2School of Public Health & Psychosocial
Studies (HY), Auckland University of Technology,
Auckland, New Zealand; 3School of Medical
Sciences, The University of Auckland, Auckland,
New Zealand
3076 — B0063 Nuclear degradation during
formation of the organelle-free zone in nonhuman primate lenses. M J. Costello1, A.
Mohamed2, K. Gilliland1, J. Wenke3, K. L. Schey3.
1
Cell Biology and Physiology, University of North
Carolina, Chapel Hill, NC; 2LV Prasad Eye Institute,
Prof. Brien Holden Eye Research Centre, L V
Prasad Eye Institute, Hyderabad, India;, Hyderabad,
India; 3Biochemistry, Vanderbilt University,
Nashville, TN
3077 — B0064 Determination of the best
method of ex vivo conservation of the crystalline
lens. Amparo Navea1, A. Fandiño1, A. Felipe1, C.
Artigas2, J. M. Artigas1. 1FISABIO Oftalmologia
(FOM), Valencia, Spain; 2Universidad Cardenal
Herrera CEU, Valencia, Spain
3072 — B0059 The Role of BASP-1 and
MARCKS in Lens Cytoarchitecture and
Function. Rasiah Pratheepa kumari, N. Skiba, V.
Rao. Opthalmology, Duke University, Durham, NC
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
218
Tuesday – Posters – 3078 – 3101
Exhibit/Poster Hall B0065-B0088
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Eye Movements/Strabismus/Amblyopia/NeuroOphthalmology
317 Amblyopia
Moderators: Jingyun Wang and
Frank A. Proudlock
3078 — B0065 Binocular iPad game treatment
for amblyopia is more successful than
patching. Krista R. Kelly1, R. M. Jost1, L. Dao2,
C. L. Beauchamp2, J. N. Leffler3, E. E. Birch1, 4.
1
Retina Foundation of the Southwest, Dallas, TX;
2
Pediatric Ophthalmology, PA, The Center for Adult
Strabismus, Dallas, TX; 3Children’s Eye Care of
North Texas, PA, Dallas, TX; 4Ophthalmology,
University of Texas Southwestern Medical Center,
Dallas, TX f
3080 — B0067 Play Station PortableTM as
a therapy for amblyopia in children. Ricardo
Torres-Vidal, J. Villaseñor-Solares, A. Ortiz Flores,
M. Cedillo-Ley, G. Garcia-Guzman. Asociacion
para Evitar la Ceguera en Mexico, Mexico City,
Mexico
3081 — B0068 Newly Developed Binocular
Treatment of Amblyopia using Head-Mounted
Display. Haeng Jin Lee, S. Kim. Ophthalmology,
Seoul National University Hospital, Seoul, Korea
(the Republic of)
3082 — B0069 Perceptual training significantly
improves visual functions in children with
amblyopia. Ge Chen1, L. Wang2, F. Hou3, Z. Lu3, C.
Huang1. 1Chinese Academy of Sciences, Institute
of Psychology, Beijing, China; 2Department of
Ophthalmology, Peking University People’s
Hospital, Beijing, China; 3Department of
Psychology, The Ohio State University, Columbus,
OH *CR
3083 — B0070 Baseline factors and visual
acuity outcome following binocular amblyopia
treatment. Angie De La Cruz1, R. M. Jost1, K. R.
Kelly1, E. E. Birch1, 2. 1Pediatric Vision Laboratory,
Retina Foundation of the Southwest, Dallas, TX;
2
University of Texas Southwestern Medical Center,
Dallas, TX
3084 — B0071 Do reminders on a smartphone
increase compliance in amblyopia treatment?
Aldo Vagge, K. Gunton, B. Schnall. Wills Eye
Hospital, Philadelphia, PA
3086 — B0073 Quality of life and functional
vision concerns of children with cataracts and
their parents. Yolanda S. Castañeda1, C. S. ChengPatel1, D. A. Leske2, S. M. Wernimont2, S. R. Hatt2,
L. Liebermann2, E. E. Birch1, 3, J. M. Holmes2.
1
Retina Foundation of the Southwest, Dallas, TX;
2
Department of Ophthalmology, Mayo Clinic,
Rochester, MN; 3UT Southwestern Medical Center,
Dallas, TX
3093 — B0080 Amblyopia Treatment
Outcomes Assessment Using AAO’s IRIS-7
Measure. Constance E. West1, 2, P. Cobb1, D. L.
White3. 1Pediatric Ophthalmology, Cincinnati
Childrens Hospital Medical Center, Cincinnati,
OH; 2Department of Ophthalmology, University of
Cincinnati, Cincinnati, OH; 3James M Anderson
Center, Cincinnati Childrens Hospital Medical
Center, Cincinnati, OH *CR
3094 — B0081 New Pediatric Vision
Screener - Data Analysis and Validation. Boris
I. Gramatikov, K. Irsch, Y. Wu, D. L. Guyton.
Ophthalmology, Johns Hopkins Wilmer Eye Inst,
Baltimore, MD *CR
3087 — B0074 Interocular contrast differences
and the stability of fixational eye movements.
Rajkumar Nallour Raveendran, W. R. Bobier, R. J.
Babu, B. Thompson. Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada
3095 — B0082 Dilated Eye Examination among
Multi-ethnic Preschool Children. Xuejuan Jiang1,
K. Tarczy-Hornoch2, 3, S. A. Cotter4, M. Torres1,
R. Varma1. 1USC Eye Institute/Department of
Ophthalmology, University of Southern California,
Los Angeles, CA; 2Ophthalmology, University
of Washington, Seattle, WA; 3Seattle Children’s
Hospital, Seattle, WA; 4Southern California College
of Optometry, at Marshall B. Ketchum University,
Fullterton, CA
3088 — B0075 Effects of amblyopia
and strabismus on the performance of a
manipulation task involving precision grasping,
placement, and action sequencing. Ewa
Niechwiej-Szwedo, D. A. Gonzalez. Department of
Kinesiology, University of Waterloo, Waterloo,
ON, Canada
3096 — B0083 Comparison of the Amblyopia
Preferred Practice Patterns of the American
Academy of Ophthalmology with the Practices
of an Academic Pediatric Ophthalmology
Division. Tehilla Steiner, I. Friedman, J. Rosenberg.
Ophthalmology, Montefiore Medical Center,
Bronx, NY
3089 — B0076 Distance versus near visual
acuity in older children and adults with
amblyopia. Cindy X. Guo. Optometry and Vision
Science, University of Auckland, Auckland, New
Zealand f
3097 — B0084 Assessment of the plusoptiX A12
photoscreener to detect amblyogenic risk factors
in Nebraska. Thomas Williams1, D. Suh2, 3. 1School
of Medicine, Creighton University School of
Medicine, Omaha, NE; 2Ophthalmology and Visual
Sciences, University of Nebraska Medical Center,
Omaha, NE; 3Pediatric Ophthalmology, Children’s
Hospital and Medical Center, Omaha, NE
3090 — B0077 Interocular differences in
size perception of black-white figure ground
asymmetries in anisometropic amblyopia. jing
liu, J. Li, Z. Chen, X. Cai, J. Yuan, D. Deng, M.
Yu. State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Center,Sun Yat-Sen
University, Guangzhou, China
3091 — B0078 Sparing of coarse stereopsis in
stereodeficient children depends on amblyogenic
factors. Kimberly Meier1, B. Sum2, L. M. Wilcox3,
D. Giaschi2. 1Department of Psychology, University
of British Columbia, Vancouver, BC, Canada;
2
Department of Ophthalmology & Visual Sciences,
University of British Columbia, Vancouver,
BC, Canada; 3Department of Psychology, York
University, Toronto, ON, Canada
3092 — B0079 Comparison of two angular
eye charts for assessment of visual acuity in
amblyopia : Thibaudet and Snellen tests. Claire
Iscar1, 2, V. Promelle1, 2, E. Haritchabalet1, S.
Milazzo1, 2.1Ophthalmology, Amiens University
Hospital, Amiens, France; 2Université de Picardie
Jules Verne, Amiens, France
3098 — B0085 Assessment of the OPTEC
vision screener in the detection of amblyopia
in the pediatric population. Mary Haschke, H.
Kinberg, D. W. Suh. U of Nebraska Medical Center,
Omaha, NE
3099 — B0086 Referral basis for infantile
cataracts. Priyanka Kumar, P. Lenhart, S. R.
Lambert. Emory Eye Clinic, Atlanta, GA
3100 — B0087 Visual Profile of Children
Passing/Failing a UK School Vision Screening
Protocol. Kathryn Saunders, L. O’Donoghue,
S. McCullough. Biomedical Sciences Research
Institute, Ulster University, Coleraine, United
Kingdom
3101 — B0088 Preschool Vision Screening by
Parents Using an iPad in Saudi Arabia. Noura
A. Aldossary1, 2, A. M. AlSaqr2, E. B. Ciner1, N.
Aldohayan3. 1Salus University, Riyadh, Saudi
Arabia; 2Optometry Department, King Saud
University, Riyadh, Saudi Arabia; 3Ophthalmology,
Prince Sultan Military Medical City, Riyadh,
Saudi Arabia
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
219
Tuesday Posters
8:30 am – 10:15 am
3079 — B0066 A Randomized Trial of
AmblyzTM Liquid Crystal Occlusion Glasses vs
Traditional Patching for Treatment of Moderate
Unilateral Amblyopia in Children: 6-Month
Outcome. Paxton Ott1, D. Neely1, J. Galli1, T.
Damarjian1, J. Schliesser1, H. Smith1, K. Haider1,
G. Roberts1, D. Sprunger1, D. Plager1, J. Wang2.
1
Vision Sciences, Indiana University School of
Medicine, Clayton, IN; 2Pennsylvania College of
Optometry, Salus University, Elkins Park, PA f
3085 — B0072 Trends in the incidence and
causes of amblyopia and strabismus among
teenagers. Yinon Shapira1, M. Mimouni1, Y.
Machluf2, Y. Chaiter3, E. Mezer1, 4. 1Ophthalmology,
Rambam Healthcare Campus, Haifa, Israel;
2
Weizmann Institute of Sciences, Rechovot, Israel;
3
Israel Defense Forces, Medical Corps, Haifa,
Israel; 4Bruce and Ruth Rappaport Faculty of
Medicine, Technion, Israel Institute of Technology,
Haifa, Israel
3102 – 3126 – Tuesday – Posters
Exhibit/Poster Hall B0107-B0136
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Visual Psychophysics/Physiological Optics
318 IOL Optical Properties and
Presbyopia Correction
Moderators: Fabrice Manns and Geunyoung Yoon
Tuesday Posters
8:30 am – 10:15 am
3102 — B0107 Comparative Analysis of
Accuracy and Predictability of Intraocular Lens
Power Calculation after Refractive Surgery:
Conventional Regression Formula versus ASCRS
Calculator. Byeong Soo Kang1, J. Oh1, 2, M. Kim1, 2,
W. Wee1, 2. 1Department of Ophthalmology, Seoul
National University Hospital, Seoul, Korea (the
Republic of); 2Laboratory of Ocular Regenerative
Medicine and Immunology, Biomedical Research
Institute, Seoul National University Hospital, Seoul,
Korea (the Republic of)
3103 — B0108 Corneal curvature is
a key determinant of Haigis and SRKT
formulae accuracy of for intentional myopic
overcorrection. Andre Messias, R. F. Dalto, F.
Miriam, W. Queiroz, R. P. Coelho, J. S. Paula.
Ophthalmology, University of Sao Paulo, Ribeirao
Preto, Brazil
3104 — B0109 The tolerance analyses of
cylindrical axial misalignment of a TIOL.
Huawei Zhao. R&D, Abbott Medical Optics, Inc.,
Santa Ana, CA *CR
3105 — B0110 An objective method to measure
astigmatism tolerance with a small-aperture vs.
monofocal intraocular lens. Eugenia K. Thomas1,
L. Lin1, S. Vilupuru1, R. Ang2. 1Clinical Research,
AcuFocus, Inc., Irvine, CA; 2Asian Eye Institute,
Makati City, Philippines *CR
3106 — B0111 Masurement of the pseudoaccommodation curve of intraocular lenses in
virtually implanted subjects. Jaume Pujol1, S.
O. Luque2. 1Physiology & Membrane Biology,
Universitat Politecnica Catalunya, Terrassa, Spain;
2
10Lens S.L.U., Terrassa, Spain *CR
3107 — B0112 Long Term Follow-up of
Posterior Chamber Phakic Intraocular Lens for
Myopia. Bronson M. LeClair1, 2, H. V. Gimbel1, 2,
J. T. Fan1. 1School of Medicine, Loma Linda
Univeristy, Loma Linda, CA; 2Gimbel Eye Centre,
Calgary, AB, Canada
3108 — B0113 Refractive and safety outcomes
of individuals submitted to phakic intraocular
lens implantation (ICL) and correlation of
ocular measurements. Fabio Kenji K. Matsumoto.
Ophthalmology, São Paulo Federal University UNIFESP, São Paulo, Brazil
3109 — B0114 Bilateral Macular Protection
Pigment and Lens Density Status in Recently
Operated Unilateral Pseudophakic Patients.
Amy Schnegg1, 2, W. E. Sponsel1, 2, R. A. Bone3,
M. A. Reilly4, S. Leon2, S. Cervantes1. 1William
E. Sponsel, M.D., San Antonio, TX; 2Rosenberg
School of Optometry, University of the Incarnate
Word, San Antonio, TX; 3Physics, Florida
International University, Miami, FL; 4Biomedical
Engineering, University of Texas San Antonio, San
Antonio, TX *CR
3110 — B0115 Chromatic aberration of
intraocular lenses measured in vitro and in vivo.
Daniel H. Chang1, H. A. Weeber2, M. Lowery3, P.
Piers2. 1Empire Eye and Laser Center, Bakersfield,
CA; 2Abbott Medical Optics, Groningen,
Netherlands; 3Abbott Medical Optics, Santa Ana,
CA *CR
3111 — B0116 Intraocular lens with
heterogeneous refractive index correcting field
and chromatic aberrations. Enrique-Josua
Fernandez, P. Artal. Physics, Universidad de
Murcia, Murcia, Spain *CR
3112 — B0117 Implantation of an add-on
intraocular lens for patients with age-related
macula degeneration. Uwe Oberheide1, 2, O.
Kermani2, G. Gerten2. 1Applied optics and
electronics, TH Köln Cologne University of Applied
Sciences, Cologne, Germany; 2Augenklinik am
Neumarkt, Cologne, Germany *CR
3113 — B0118 In vivo evaluation of the tilt in
the human crystalline lens or intraocular lens
using a full-length optical coherence tomography
(OCT)-based biometer. AKENO TAMAOKI1, 2, T.
Kojima3, T. Buehren5, R. Hashizume1, Y. Tanaka4, K.
Tanaka6, 2, K. Ichikawa4. 1Ophthalmology, Chukyo
Hospital, Nagoya, Japan; 2Shinshu University
Interdisciplinary Graduate School of Science and
Technology, Nagano, Japan;3Ophthalmology,
Gifu Red Cross Hospital, Gifu, Japan; 4Chukyo
Eye Clinic, Nagoya, Japan; 5Carl Zeiss Meditec,
Jena, Germany; 6Faculty of Engineering, Shinshu
University, Nagano, Japan *CR
3114 — B0119 Visual quality with combinations
of optimized and non-optimized corrective
elements. Georgios Zoulinakis1, R. Montés-Micó1,
T. Ferrer Blasco1, D. Iskander2. 1Faculty of Physics,
University of Valencia, Valencia, Spain; 2Wroclaw
University of Technology, Wroclaw, Poland
3115 — B0120 Assessing the optical quality
of commercially available intraocular lenses
by means of modulation transfer function and
straylight. Eleni Papadatou1, G. Labuz2, T. J. Van
Den Berg2, J. Esteve-Taboada1, D. Madrid-Costa1,
N. Lopez-Gil3, R. Montés-Micó1. 1University of
Valencia, Valencia, Spain; 2Rotterdam Ophthalmic
Institute, Rotterdam, Netherlands; 3University of
Murcia, Murcia, Spain *CR
3116 — B0121 Straylight measurements in
intraocular lenses with an optical integration
method. Alexandros Pennos, H. S. Ginis,
A. Gambin, P. Artal. Laboratorio de Optica,
Universidad de Murcia, Murcia, Spain
3117 — B0122 Halo measurement method
for intraocular lenses. Marrie Van der Mooren,
P. Piers, J. Graver, H. A. Weeber. R&D Implants,
AMO Groningen BV, Groningen, Netherlands *CR
3118 — B0123 Parameters affecting both Far
Peripheral Vision in phakic eyes and Negative
Dysphotopsia with Intraocular Lenses. Michael
Simpson. Simpson Optics LLC, Arlington, TX
3119 — B0124 Age-related objective and
subjective dysphotopsia. Maana Aujla1, J.
Wolffsohn1, 2, A. L. Sheppard1, 2. 1School of Life and
Health Sciences, Aston University, Birmingham,
United Kingdom; 2Aston Research Centre for
Healthy Ageing, Aston University, Birmingham,
United Kingdom
3120 — B0125 Impact of Stiles-Crawford peak
decentration with small apertures. Pedro Prieto,
S. Manzanera, C. Robles, P. Artal. Laboratorio de
Óptica, Universidad de Murcia, Murcia, Spain *CR
3121 — B0126 Clinical efficacy of pihhole soft
contact lenses for correcting presbyopia. Si Yoon
Park, T. Kim, J. Jung, Y. Ji, E. Kim, K. Seo, H.
Lee. Department of Ophthalmology, Department
of Ophthalmology, Yonsei University College of
Medicine, Seoul, Korea (the Republic of) f
3122 — B0127 Clinical Correlates of Multifocal
Defocus Curve. Linda Tsai, S. Kasthurirangan, J.
Depew, P. Smith, K. Featherstone. Abbott Medical
Optics, Santa Ana, CA *CR, f
3123 — B0128 Toric Multifocal Intraocular
Lens: 24 months Follow-Up. Valeria Oliva, A.
Navas. Cornea, Conde de Valenciana, Mexico,
Mexico
3124 — B0129 Crosslink Gain-Control
Model to Predict Binocular Defocus Curve
for Multifocal Intraocular Lenses. Lin He, S.
Jasti. Global Clinical & Regulatory Affairs, Alcon
Laboratories Inc. (Novartis), Ft Worth, TX *CR
3125 — B0130 Impact of higher-order
aberrations on depth-of-field. Juan F. ZapataDiaz1, I. Marin-Franch2, 3, H. Radhakrishnan1,
N. Lopez-Gil3. 1Optometry, The University of
Manchester, Manchester, United Kingdom; 2Óptica
y Optometría y Ciencias de la Visión, Universitat
de València, Valencia, Spain; 3Ciencias de la Visión
research group, Universidad de Murcia, Murcia,
Spain
3126 — B0131 Subjective preference to
orientation of an angular bifocal IOL design.
Aiswaryah Radhakrishnan, C. Dorronsoro, S.
Marcos. Instituto de Optica, CSIC, Madrid, Spain
*CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
220
Tuesday – Posters – 3127 – 3144
3127 — B0132 Preclinical evaluation of
tolerance to astigmatism with an extended range
of vision IOL. Carmen Canovas, A. Alarcon, J.
Graver, H. A. Weeber, P. A. Piers. R&D, AMO
Groningen B.V., Groningen, Netherlands *CR
3128 — B0133 Testing vision with physical
and simulated multifocal corrections in an
adaptive optics visual simulator. Maria Vinas1,
C. Dorronsoro1, A. Radhakrishnan1, E. LaVilla2,
J. Schwiegerling2, S. Marcos1. 1Instituto de Optica
(CSIC), Madrid, Spain; 2College of Optical
Sciences. University of Arizona, Tucson, AZ
3129 — B0134 Eye Tracker with Distance
Measurement for Autofocus Eyeglass. Zengzhuo
Li2, 1, G. Li2, 1. 1Electrical and computer engineering,
The Ohio State University, Columbus, OH;
2
Department of Ophthalmology and Visual Science,
The Ohio State University, Columbus, OH
3131 — B0136 Design and evaluation of a
surface-changing accommodating IOL. Andres
De La Hoz1, E. Martinez-Enriquez1, H. Subhash1, D.
Pascual1, N. Bekesi1, C. Dorronsoro1, N. AlejandreAlba1, 2, S. Marcos1. 1Instituto de Optica, CSIC,
Madrid, Spain; 2Fundación Jimenez Díaz, Madrid,
Spain *CR
Exhibit/Poster Hall B0232-B0270
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Genetics Group
319 Retinal Genetics
Moderators: Jacque L. Duncan and Carlo Rivolta
3132 — B0232 A tandem duplication of
PRDM13 in a family with North Carolina
Macular Dystrophy (MCRD1). Lori S. Sullivan1,
S. J. Bowne1, D. C. Koboldt2, R. S. Fulton2, K. G.
Locke3, K. D. Webb-Jones3, D. K. Wheaton3, R.
K. Wilson2, D. G. Birch3, S. P. Daiger1, 4. 1Human
Genetics Center, Univ Texas Hlth Sci Ctr Houston,
Houston, TX; 2The Genome Institute, Washington
University School of Medicine, St. Louis,
MO;3Retina Foundation of the Southwest, Dallas,
TX; 4Ruiz Dept. of Ophthalmology, Univ Texas
Hlth Sci Ctr Houston, Houston, TX
3134 — B0234 SRD5A3: a gene for complex
LCA and early onset retinal dystrophy. Elise
Heon1, 2, S. Li2, 1, E. Tavares2, 1, H. Macdonald1, A.
Vincent1. 1Ophthalmology and Vision Sciences, The
Hospital for Sick Children, Toronto, ON, Canada;
2
Genetics and Genome Biology, The Hospital for
Sick Children, Toronto, ON, Canada
3135 — B0235 Complex Multi-Allelic Inherited
Retinal Dystrophy: Multiple Genes Contributing
Independently and Concurrently in Extended
Families. Dianna K. Wheaton1, 4, K. D. WebbJones1, S. J. Bowne2, L. S. Sullivan2, R. Chen3, S. P.
Daiger2, D. G. Birch1, 4. 1Retina Foundation of the
Southwest, Dallas, TX; 2Univ Texas Health Science
Center, Houston, TX; 3Baylor College of Medicine,
Houston, TX; 4Ophthalmology, Univ Texas
Southwestern Medical Center, Dallas, TX
3136 — B0236 Heterogeneity and complexity
of EYS mutations in autosomal recessive retinitis
pigmentosa in northern Sweden. Irina Golovleva1,
F. Jonsson1, M. Burstedt2. 1Medical Biosciences,
Umeå University, Umea, Sweden; 2Clinical
Sciences, Umeå University, Umeå, Sweden
3137 — B0237 Exome Analysis Detected a
Novel 7.4 kb Deletion in the PRPH2 Gene as
the Underlying Cause of Recessive Retinal
Degeneration in a Consanguineous Family.
Kameron Kishaba1, P. Biswas1, J. Suk1, I. Ullah2,
M. A. Naeem2, S. Riazuddin2, 3, J. Akram3, 4, J.
Hejtmancik5, S. Riazuddin6, R. Ayyagari1. 1Shiley
Eye Institute, University of California, San Diego,
La Jolla, CA; 2National Center of Excellence in
Molecular Biology, University of the Punjab,
Lahore, Pakistan; 3Allama Iqbal Medical College,
University of Health Sciences, Lahore, Pakistan;
4
National Centre for Genetic Diseases, Shaheed
Zulfiqar Ali Bhutto Medical University, Islamabad,
Pakistan; 5OMGS/OGVFB, National Eye Institute,
NIH, Bethesda, MD; 6The Wilmer Eye Institute,
John’s Hopkins University School of Medicine,
Baltimore, MD
3138 — B0238 Phenotypic Variability in
RDH12 Retinopathy. Ruifang Sui1, X. Zou1, Z. Ge2,
H. Li1, M. Xu2, R. Chen2, F. Dong1. 1Ophthalmology,
Peking Union Med College Hosp, Beijing, China;
2
Molecular and Human genetics, Baylor College of
Medicine, Houston, TX
3139 — B0239 A mutation in Adiponectin
receptor 1 causes autosomal-dominant retinitis
pigmentosa. Liping Yang. Peking University Eye
Center, Peking University Third Hospital, Beijing,
China
3140 — B0240 Mutation analysis of RHO
gene in 225 Chinese families with retinitis
pigmentosa. Jianjun Chen2, 1, L. Han2, 1, Z. Fan2, 1,
Z. Wu2, 1, Z. Zhong2, 1. 1Tongji University, Shanghai,
China;2Shanghai Tenth People’s Hospital,
Shanghai, China
3141 — B0241 Two distinct phenotypes in
the same family are caused by the Schiff base
counterion mutation p.E113K in rhodopsin.
Marta Owczarek-Lipska1, C. Reiff2, G. Spital3,
C. Roeger1, H. Hinz1, C. Jüschke1, H. Thiele4,
J. Altmüller4, P. Nürnberg4, R. Da Costa1, J.
Neidhardt1. 1Human genetics, University of
Oldenbrug, Oldenburg, Germany; 2Eye Center,
Albert-Ludwigs-University of Freiburg, Freiburg,
Germany;3Ophthalmology, St. Franziskus-Hospital,
Münster, Germany; 4Cologne Center for Genomics,
University of Cologne, Cologne, Germany
3142 — B0242 Autosomal dominant Retinitis
Pigmentosa caused by a deletion not reported
in the human rhodopsin gene: a case report.
Maria Moussalli. Ophthalmology, Hospital Italiano,
Capital Federal, Argentina
3143 — B0243 Identification of the first
CHM promoter mutation in a patient with
choroideremia. Alina Radziwon, I. M. MacDonald.
Ophthalmology, University of Alberta, Edmonton,
AB, Canada
3144 — B0244 Identification of a novel
frame-shift deletion in the CHM gene in a
consanguineous family. Aditya A. Guru1, P.
Biswas1, J. Suk1, K. Kishaba1, I. Ullah2, M.
A. Naeem2, S. Riazuddin2, 3, S. Riazuddin4, R.
Ayyagari1, J. Hejtmancik5. 1Shiley Eye Institute,
UCSD, San Diego, CA; 2National Centre of
Excellence in Molecular Biology, University of the
Punjab, Lahore, Pakistan; 3Allama Iqbal Medical
College, University of Health Sciences, Lahore,
Pakistan; 4The Wilmer Eye Institute, Johns Hopkins
University School of Medicine, Baltimore, MD;
5
OMGS/OGVFB, National Eye Institute, NIH,
Bethesda, MD *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
221
Tuesday Posters
8:30 am – 10:15 am
3130 — B0135 The Effect of Peripherally
Positioned Capsulorhexis in Phaco Ersatz
studied using 3D Finite Element Model.
Hooman Mohammad Pour1, 2, S. Devineni2, S.
Kanapathipillai2, F. Manns3, 4, A. Ho1, 5. 1Brien
Holden Vision Institute, Kensington, NSW,
Australia; 2Mechanical and Manufacturing
Engineering, University of New South Wales,
Kensington, NSW, Australia; 3Ophthalmic
Biophysics Center, Bascom Palmer Eye Institute,
University of Miami, Miami, FL; 4Department of
Biomedical Engineering, Biomedical Optics and
Laser Laboratory, University of Miami, Miami,
FL; 5School of Optometry and Vision Science,
University of New South Wales, Kensington, NSW,
Australia
3133 — B0233 North Carolina Macular
Dystrophy (NCMD / MCDR1) mutations found;
PRDM13. Kent W. Small1, A. P. DeLuca5, F. P.
Cremers3, C. Hoyng3, M. J. Leys2, B. Bakall6, R.
A. Lewis4, R. Silva-Garcia1, K. Rohrschneider7,
E. M. Stone5, 8. 1Molecular Insight, Research
Foundation, Glendale, CA; 2cell biology, neurology
and anatomy, WVU Eye Institute, Morgantown,
WV; 3Biology, Raboud University Medical
Center, Nijmegen, Netherlands; 4Baylor College
of Medicine, Houston, TX; 5Department of
Ophthalmology and Visual Sciences, Stephen A.
Wynn Institute for Vision Research, Iowa City,
IA; 6Associated Retina Consultants, University
of Arizona College of Medicine, Phoenix, AZ;
7
University of Heidelberg, Heidelberg, Germany;
8
The Stephen A. Wynn Institute for Vision
Research, Iowa City, IA
3145 – 3163 – Tuesday – Posters
3145 — B0245 Variable expression of TIMP3related maculopathy due to an atypical mutation
in a large family. Jerry Lee1, R. Sisk2, C. Linne3,
L. Krueger4, S. Schoenberger5, L. Fritsche6, E. Y.
Chew7, B. P. Brooks1, A. Agarwal8, Z. Ahmed9, R.
B. Hufnagel1. 1Ophthalmic Genetics and Visual
Function Branch, National Eye Institute (NEI/NIH),
Bethesda, MD; 2Cincinnati Eye Institute, Cincinnati,
OH; 3Washington University, St. Louis, MO;
4
University of Kentucky, Lexington, KY; 5Retina
Physicians and Surgeons, Dayton, OH; 6University
of Michigan, Ann Arbor, MI; 7National Eye Institute
(NEI/NIH), Bethesda, MD; 8Vanderbilt University,
Nashville, TN; 9University of Maryland,
Baltimore, MD
Tuesday Posters
8:30 am – 10:15 am
3146 — B0246 Challenges in the diagnosis
of autosomal recessive bestrophinopathy:
additional case reports. Benedikt Book1, H. B.
Stoehr2, B. H. Weber2, G. Spital1. 1Department of
Ophthalmology, St. Franziskus Hospital Muenster,
Muenster, Germany; 2Institute of Human Genetics,
University Regensburg, Regensburg, Germany *CR
3147 — B0247 Novel genetic variants
causing hereditary vitreoretinopathies. Diem
K. Bui1, N. Jain1, G. B. Hubbard1, S. Shankar1, 2.
1
Ophthalmology, Emory Eye Center, Atlanta, GA;
2
Department of Human Genetics, Emory University,
Atlanta, GA
3148 — B0248 Frmd4b Suppresses Retinal
Dysplasia in Nr2e3rd7 Mice by Restoring the
Integrity of External Limiting Membrane. Yang
Kong1, 2, J. R. Charette1, J. Naggert1, L. Zhao1, P.
M. Nishina1, 2.1The Jackson Laboratory, Bar Harbor,
ME; 2The Graduate School of Biomedical Science
and Engineering, University of Maine, Orono, ME
3149 — B0249 Zebrafish and Mouse
Models with Mutations in the Novel Gene
ASRGL1 Develop Retinal Degeneration (RD)
Recapitulating the Human Phenotype. Pooja
Biswas1, V. R. Chavali2, N. W. Khan3, J. Suk1, M.
Homsher2, S. Riazuddin4, 5, J. Hejtmancik6, S.
Riazuddin7, R. Ayyagari1. 1Shiley Eye Institute,
University of California San Diego, La Jolla, CA;
2
Ophthalmology, University of Pennsylvania,
Philadelphia, PA;3W.K. Kellogg Eye Center,
University of Michigan, Ann Arbor, MI; 4National
Centre of Excellence in Molecular Biology,
University of the Punjab, Lahore, Pakistan; 5Allama
Iqbal Medical College, University of Health
Sciences, Lahore, Pakistan; 6OMGS/OGVFB,
National Eye Institute, NIH, Bethesda, MD; 7The
Wilmer Eye Institute, Johns Hopkins University
School of Medicine, Baltimore, MD
3151 — B0251 Generation and characterization
of Fam161a Conditional Knockout mice. Avigail
Beryozkin1, A. Obolensky1, S. Meyer1, A. Ejzenberg1,
C. Matsevich1, Y. Arsenijevic2, C. Rivolta2, E.
Banin1, D. Sharon1. 1Ophthalmology, HadassahHebrew University Medical Center, Jerusalem,
Israel; 2University of Lausanne, Lusanne,
Switzerland
3152 — B0252 A spontaneous Kunming mouse
for Usher syndrome caused by homozygous
mutations of Ush2a and Pde6b. Zuoming Zhang2, 1,
L. Zhang2, L. Yao2, J. Xue2. 1Ophthalmology &
Visual Science, Fourth Military Medical Univ,
Xi’an, China; 2Clinical Aerospace Medicine, Fourth
Military Medical University, Xi’an, China
3153 — B0253 Whole exome sequencing
reveals a homozygous splicing mutation in
CEP78 as the cause of atypical Usher syndrome
in Eastern Jewish patients. Dror Sharon1,
P. Namburi1, R. Ratnapriya2, C. Lazar2, A.
Obolensky1, T. Ben-Yosef3, E. Pras4, M. Gross5, E.
Banin1, A. Swaroop2. 1Ophthalmology, HadassahHebrew Univ Medical Ctr, Jerusalem, Israel;
2
Neurobiology-Neurodegeneration & Repair
Laboratory, National Eye Institute, National
Institutes of Health, Bethesda, MD; 3The Rappaport
Faculty of Medicine, Technion-Israel Institute of
Technology, Haifa, Israel; 4Ophthalmology, Assaf
Harofeh Medical Center, Zerifin, Israel;5Department
of Otolaryngology - Head and Neck Surgery,
Hadassah-Hebrew University Medical Center,
Jerusalem, Israel., Jerusalem, Israel
3154 — B0254 The Genetics of Usher
Syndrome in the Israeli and Palestinian
Populations. Samer Khateb1, A. Khalaileh1, T. BenYosef2, A. Raas-Rothschild2, I. Chowers1, E. Banin1,
D. Sharon1. 1Genetics Department, Meir Medical
Center, Kfar Saba, Israel; 2Genetics department,
Technion-Israel Institute of Technology, Haifa, Israel
3155 — B0255 HDAC1/2 are critical for RPE
homeostasis and health. Mark E. Kleinman, K.
Jung, J. Roney, S. C. Prajapati, D. Lou, S. Dubey,
J. Brown, K. Mohan. Ophthalmology and Visual
Sciences, University of Kentucky, Lexington, KY
*CR
3156 — B0256 Genetic Testing Based on Next
Generation Sequencing (NGS) for Retinitis
Pigmentosa (RP) in Brazilian Patients. Juliana
M. Sallum1, K. A. Costa1, M. Salles1, J. P. Chiang2.
1
Ophthalmology, UNIFESP, Sao Paulo, Brazil;
2
Genetic Eye Diseases, Oregon Health Sciences
University, Portland, OR
3150 — B0250 A new mouse model of cone
photoreceptor function loss (cpfl9) with cone
photoreceptor degeneration. Bo Chang, J. Wang,
B. FitzMaurice. Ophthalmology, The Jackson
Laboratory, Bar Harbor, ME
3157 — B0257 Diagnostic Utility of a Next
Generation Sequencing Retinal Panel in a
Māori and Polynesian population with Inherited
Retinal Disease. Andrea L. Vincent1, 2, A. Coysh1,
K. Van Bysterveldt1, V. F. Oliver1, G. C. Black3.
1
Ophthalmology, New Zealand National Eye
Centre, University of Auckland, Auckland, New
Zealand; 2Eye Department, Greenlane Clinical
Centre, Auckland District Health Board, Auckland,
New Zealand; 3Manchester Centre for Genomic
Medicine, Institute of Human Development,
University of Manchester, Manchester, United
Kingdom
3158 — B0258 Comprehensive Molecular
Diagnosis of a Large Chinese Patient Cohort
With Autosomal Dominant Retinitis Pigmentosa.
Fei Xu1, 2, M. Xu3, Z. Sun1, Z. Ge3, H. Li1, Y. Li3,
L. Yang1, H. Zhang2, F. Dong1, R. Chen3, R. Sui1.
1
ophthalmology, Peking Union Medical College
Hospital, Beijing, China; 2Ophthalmology, Eye
Hospital, China Academy of Chinese Medical
Sciences, Beijing, China; 3Molecular and Human
Genetics, Human Genome Sequencing Center,
Baylor College of Medicine, Houston, TX
3159 — B0259 Phenotype Based Targeted Next
Generation Sequencing Complemented with
Microarray Analysis has high yield in Clinical
Genetic Testing of Inherited Eye Disorders. Suma
P. Shankar1, 2, J. Yan2, S. Richards1, B. Bunke1, M.
Hegde1, J. Alexander1. 1Human Genetics, Emory
University School of Medicine, Atlanta, GA;
2
Ophthalmology, Emory University School of
Medicine, Atlanta, GA
3160 — B0260 Retinal panel exome
sequencing- a diagnostic tool to hereditary
retinal disorders. Dinesh Kumar Kandaswamy1, 2,
M. Prakash3, J. Graw2, S. T. Santhiya1. 1Department
of Genetics, Dr ALM PG IBMS, University of
Madras, Chennai, India; 2Institute of Developmental
Genetics, Helmholtz Zentrum Munchen, Munich,
Germany; 3Retinal Unit, Regional Institute of
Ophthalmology, Egmore Eye Hospital, Chennai, India
3161 — B0261 RetDegenDx: A retinal
dystrophy genetic diagnosis prediction tool. Dana
Schlegel1, B. Katz2, V. Bichucher2, R. Starbuck2,
W. Xu2, J. Durrah2, E. Al-Sharif1, A. DeOrio2, N.
W. Khan1, K. T. Jayasundera1. 1Retinal Dystrophy,
Kellogg Eye Center, Ann Arbor, MI; 2University of
Michigan, Ann Arbor, MI
3162 — B0262 Unfolding mutation screen for
inherited eye disease. Caitlyn McCafferty, Y. V.
Sergeev. National Eye Institute, National Institutes
of Health, Washington DC, DC
3163 — B0263 In-silico unfolding: a role
of missense changes in Stargardt’s disease.
Yuri V. Sergeev1, C. McCafferty1, K. Fujinami2,
B. Falsini1, 3, W. M. Zein1, K. T. Jayasundera4,
M. Michaelides5, B. P. Brooks1, P. A. Sieving1.
1
OGVFB, National Eye Institute, Bethesda, MD;
2
National Institute of Sensory Organs, Tokyo,
Japan; 3Catholic Medical University, Rome,
Italy; 4University of Michigan, Ann Arbor, MI;
5
Moorfields Eye Hospital, London, United Kingdom
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
222
Tuesday – Posters – 3164 – 3181
3164 — B0264 Influence of Risk Alleles
for Age-Related Macular Degeneration on
Recessive Stargardt Disease Phenotypes.
Robert Sisk1, 2, R. B. Hufnagel3, B. Zanke4,
Z. Ahmed3. 1Ophthalmology, University of
Cincinnati, Cincinnati, OH; 2Ophthalmology,
Cincinnati Children’s Hospital, Cincinnati,
OH; 3Otolaryngology, University of Maryland,
Baltimore, MD; 4Arctic Dx, Bonita Springs, FL *CR
3165 — B0265 A combination of
oculopharyngeal muscular dystrophy and
a variant of enhanced S-cone syndrome in
Bukharan Jews due to linked mutations
in PABPN1 and NRL. Tamar Ben-Yosef1, H.
Newman2, I. Braverman3, 1, S. Blumen3, 1, R. Hanna3,
B. Tiosano3, I. Perlman1, 2. 1Technion, Haifa, Israel;
2
Ophthalmology, Tel-Aviv Medical Center, Tel Aviv,
Israel; 3Hillel Yaffe Medical Center, Hadera, Israel
3166 — B0266 Interrogating the M/L Opsin
Cluster using Exome Sequencing. Adam P.
DeLuca, S. Whitmore, R. M. Johnston, J. S. East,
H. T. Daggett, J. M. Hoffmann, T. E. Scheetz, E.
M. Stone. Stephen A. Wynn Institute for Vision
Research, University of Iowa, Iowa City, IA
3168 — B0268 Quantitative Analysis of
Photoreceptor Swelling in Late-Onset Retinal
Degeneration Using Adaptive Optics. Jianfei
Liu, C. A. Cukras, J. Tam. National Eye Institute,
National Institutes of Health, Bethesda, MD
3169 — B0269 How multimodal retinal
imaging can help with Next Generation
Sequencing interpretation: the example of cone
and cone-rod dystrophies. Elise BoulangerSemama1, 3, S. El Shamieh2, S. Mohand-Said2,
3
, V. Démontant2, C. Condroyer2, A. Antonio2,
C. Michiels2, F. Boyard2, J. Sahel2, 3, C. Zeitz2,
I. S. Audo2, 3. 1Ophthalmology, Fondation
Ophtalmologique Adolphe de Rothschild, Paris,
France; 2INSERM, U968, CNRS, UMR_7210,
Sorbonne Universités, UPMC Univ Paris 06,
UMR_S 968, Institut de la Vision, Paris, F-75012,
France; 3DHU ViewMaintain, INSERM-DHOS CIC
1423, Centre Hospitalier National d’Ophtalmologie
des Quinze-Vingts, Paris, F-75012, France
Exhibit/Poster Hall B0271-B0300
3175 — B0275 Retinal degeneration associated
with transition zone protein MKS6. Katie L.
Bales1, W. R. Lewis3, B. K. Yoder3, R. A. Kesterson2,
A. K. Gross1. 1Vision Science, University of
Alabama at Birmingham, Birmingham, AL;
2
Genetics, University of Alabama, Birmingham,
AL; 3Cellular, Developmental and Integrative
Biology, University of Alabama at Birmingham,
Birmingham, AL
3176 — B0276 RPE cell specific loss of
ERK1/2 leads to retinal degeneration. Aswin
Pyakurel1, 3, D. Balmer3, M. L. Zhu4, M. Saba El
Leil5, J. Daraspe6, B. Humbel6, L. Voisin5, Y. Le4,
J. Von Lintig2, S. Meloche5, R. Roduit1, 3. 1Hopital
ophtalmique Jules-Gonin, University of Lausanne,
Lausanne, Switzerland; 2School of Medicine,
Case Western Reserve University, Cleveland, OH;
3
Institute for Research in Ophthalmology, Sion,
Switzerland; 4University of Oklahoma Health
Sciences Center, Oklahama, OK; 5Université de
Montréal, Montreal, QC, Canada; 6University of
Lausanne, Lausanne, Switzerland
Moderators: Isabelle S. Audo and
Marina S. Gorbatyuk
3177 — B0277 Elucidating the role of Retinal
Pigment Epithelium (RPE)-specific ABCA4 in
Stargardt disease. Tamara L. Lenis1, Z. Jiang1,
S. Sarfare2, A. Le1, S. Eddington1, D. Bok1, R. S.
Molday3, S. Nusinowitz1, M. Redmond4, G. H.
Travis1, R. A. Radu1. 1Stein Eye Institute, UCLA,
Los Angeles, CA; 2Ora, Inc., Andover, MA;
3
University of British Columbia, Vancouver, BC,
Canada; 4National Eye Institute, Bethesda, MD
3171 — B0271 The USH1G scaffold protein
SANS is part of the cytoplasmic dynein transport
module in the photoreceptor inner segments.
Uwe Wolfrum1, N. Sorusch1, K. Boldt2, M. Ueffing2,
K. A. Wunderlich1. 1Cell and Matrix Biology,
Johanne Gutenberg University of Mainz, Mainz,
Germany; 2Institute for Ophthalmic Research,
University of Tübingen, Tübingen, Germany
3178 — B0278 Membrane-type Frizzled
Related Protein (MFRP) is needed for
photoreceptor cell function by retaining
docosahexaenoic acid (DHA). Nicolas G. Bazan1,
B. Jun1, B. Chang2, W. C. Gordon1.1Neuroscience
Center of Excellence, Louisiana State University
Health, New Orleans, LA; 2The Jackson Laboratory,
Bar Harbor, ME
3172 — B0272 Changes in RDS/Peripherin-2
binding properties and complex formation
underlie macular dystrophy. Rahel S. Zulliger1,
S. M. Conley2, D. Chakraborty2, M. W. Stuck2, M.
I. Naash1.1Biomedical Engineering, University of
Houston, Houston, TX; 2University of Oklahoma
Health Sciences Center, Oklahoma City, OK
3179 — B0279 Increased VEGF-A promotes
multiple distinct aging diseases of the eye
through shared pathomechanisms. Alexander
Marneros. Massachusetts General Hospital,
Charlestown, MA; Harvard Medical School,
Boston, MA
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Biochemistry/Molecular Biology
320 Molecular and biochemical
mechanisms of retinal disease
3173 — B0273 Identification of possible target
binding site in retinal degeneration 3 (RD3)
protein. Igor V. Peshenko, E. V. Olshevskaya, A. M.
Dizhoor. Research, Salus University, Elkins Park, PA
3174 — B0274 Clinical, genetic and functional
study of ABCA4 mutations in Stargardt patients.
Kailun Jiang1, L. L. Molday1, H. B. Stoehr2, B. H.
Weber2, D. Maberley1, R. S. Molday1. 1University
of British Columbia, Coquitlam, BC, Canada;
2
University of Regensburg, Regensburg, Germany
*CR
3180 — B0280 Transgenic expression of human
photoreceptor guanylyl cyclase GUCY2D with
LCA1 mutations: diversity of physiological
effects and localization in photoreceptors. Elena
V. Olshevskaya1, S. L. Boye2, K. T. McCullough2,
I. V. Peshenko1, S. E. Boye2, A. M. Dizhoor1.
1
Research, Salus University, Elkins Park, PA;
2
Ophthalmology, University of Florida, Gainesville,
FL *CR
3181 — B0281 Role of Complement-1q Tumor
Necrosis Factor Related Protein 5 (CTRP5/
C1QTNF5) in Late-Onset Retinal Degeneration
(L-ORD) Pathology. Shruthi Karnam1, V. R.
Chavali2, G. Reddy3, R. Ayyagari1. 1Shiley Eye
Institute, University of California San Diego,
La Jolla, CA; 2Ophthalmology, University of
Pennsylvania, Philadelphia, PA; 3National Institute
of Nutrition, Hyderabad, India
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
223
Tuesday Posters
8:30 am – 10:15 am
3167 — B0267 Investigations for the
underlying genetic cause in a consanguineous
family with complete achromatopsia. Markus
N. Preising, A. Zuliani, B. Lorenz. Department of
Ophthalmology, Justus-Liebig University,
Giessen, Germany
3170 — B0270 Implications of retinal imaging
for identification of Danon disease patients.
Bohdan Kousal1, 2, F. Majer2, H. Vlaskova2,
L. Dvorakova2, T. Palecek5, M. Kubanek3, V.
Stara4, J. Sikora2, P. Liskova1, 2. 1Department of
Ophthalmology, First Faculty of Medicine, Charles
University in Prague and General University
Hospital, Prague, Czech Republic; 2Institute of
Inherited Metabolic Disorders; First Faculty
of Medicine, Charles University in Prague and
General University Hospital, Prague, Czech
Republic; 3Department of Cardiology, Institute
for Clinical and Experimental Medicine, Prague,
Czech Republic; 4Pediatric Clinic, Second Faculty
of Medicine, Charles University in Prague and
Faculty Hospital Motol, Prague, Czech Republic;
5
Department of Cardiovascular Medicine, First
Faculty of Medicine, Charles University in Prague
and General University Hospital, Prague, Czech
Republic
3182– 3202 – Tuesday – Posters
3182 — B0282 Genetic dissection of rod and
cone contributions to the ERG in the living mouse.
Gabriel Peinado2, K. E. Ronning2, R. Herrmann2,
M. E. Burns2, 3, E. N. Pugh1, 3. 1Cell Biology
and Human anatomy, UC Davis, Davis, CA;
2
Center for Neuroscience, UC Davis, Davis, CA;
3
Ophthalmology and Vision Science, UC Davis,
Davis, CA
Tuesday Posters
8:30 am – 10:15 am
3183 — B0283 Functional Diversity of
Human ATF6 Mutations Associated with
Achromatopsia. Wei-Chieh Chiang1, P. Chan1,
S. Kohl2, A. Vincent3, A. Skorczyk-Werner4, M. R.
Krawczynski4, S. H. Tsang5, E. Heon3, B. Wissinger2,
J. H. Lin1. 1Pathology, University of California,
San Diego, La Jolla, CA; 2Institute for Ophthalmic
Research, University of Tubingen, Tubingen,
Germany; 3Department of Ophthalmology and
Vision Sciences, University of Toronto, Toronto,
ON, Canada; 4Department of Medical Genetics,
Poznan University of Medical Sciences, Poznan,
Poland; 5Department of Ophthalmology, Columbia
University, New York, NY
3184 — B0284 A Biochemical Analysis of the
Living Human Vitreous. Jan Kokavec, S. H. Min,
M. H. Tan, J. S. Gilhotra, H. S. Newland, S. R.
Durkin, R. J. Casson. South Australian Institute of
Ophthalmology, University of Adelaide, Adelaide,
SA, Australia
3185 — B0285 Lipidomic and Proteomic
Characterization of Subretinal Fluid in Coats
Disease. Lisa M. Lagrou1, M. D. Pawar1, A.
Capone, Jr.2, M. T. Trese2, C. G. Besirli1. 1Kellogg
Eye Center/Ophthalmology, University of
Michigan, Ann Arbor, MI; 2Associated Retinal
Consultants, Royal Oak, MI
3186 — B0286 Observed versus predicted exon
3 skipping in OPN1LW using a hexamer-linearadditive model (HAL). Maureen Neitz, J. Neitz, J.
Rowlan, C. Davidoff. Ophthalmology, University of
Washington, Seattle, WA
3187 — B0287 Sphingosine kinase 2
induces angiogenic effects by enhancing
neovascularisation in the mouse model of
retinopathy of prematurity. Jeanette Christophel1,
L. Hattenbach3, J. Pfeilschifter1, W. Pfeilschifter2.
1
Dep. of General Pharmacology and Toxicology,
Goethe University Hospital, Frankfurt/Main,
Germany; 2Dep. of Neurology, Goethe University
Hospital, Frankfurt/Main, Germany; 3Department
of Ophthalmology, Ludwigshafen Hospital,
Ludwigshafen, Germany *CR
3188 — B0288 Photoreceptor structure and
gene expression in the canine NPHP5-LCA
ciliopathy model. Louise M. Downs, E. M. Scott,
S. Genini, W. A. Beltran, G. D. Aguirre. University
of Pennsylvania, School of Vetinary Medicine,
Philadelphia, PA
3189 — B0289 Embryonic chick retinal cell
cultures: a model for Light-Induced Retinal
Degeneration (LIRD). Robin H. Schmidt1, N. F.
Henneman1, P. E. Girardot1, S. W. Gooding1, P. P.
Cunha1, J. H. Boatright1, 2. 1Ophthalmology, Emory
University, Atlanta, GA; 2Center for Visual and
Neurocognitive Rehabilitation, Atlanta, GA
3190 — B0290 Serum Hyperhomocystinemia:
A Risk Factor for Retinal Vein Occlusions.
Neha R. Chandak, S. Banait, S. Daigavane.
Ophthalmology, Datta Meghe Institute of Medical
Sciences, Nagpur, India
3191 — B0291 Localization and Functional
Analysis of ABCA4 Variants Associated
with Stargardt Disease. Laurie L. Molday1, R.
Allikmets2, R. S. Molday1. 1Biochemistry and
Molecular Biology, University of British Columbia,
Vancouver, BC, Canada; 2Ophthalmology,
Columbia University, New York City, NY
3192 — B0292 Investigating the
pathomechanism of FAM161A-associated
retinal disease in primary ciliated cells. Heidi
B. Stoehr1, M. Schwarzfischer1, L. Braun1, A.
Aslanidis2, T. Langmann2, U. Kellner3, 4. 1Human
Genetics, University Regensburg, Regensburg,
Germany; 2Laboratory for Experimental
Immunology of the Eye, University Cologne,
Cologne, Germany; 3MVZ ADTC Siegburg GmbH,
Rare Retinal Disease Center, Siegburg, Germany;
4
RetinaScience, Bonn, Germany
3193 — B0293 RPGR, a retinal ciliopathy
protein, localizes to cilia in a prenylation
dependent manner. Wei Zhang, N. R. Kollu, L. Li,
M. Anand, H. Khanna. Ophthalmology, University
of Massachusetts Medical School, Worcester, MA
3194 — B0294 Whole transcriptome
sequencing in rd10 revealed new factors and
pathways involved in stem cells biology and
neuroprotection in the inner retina and ciliary
body. Jerome E. Roger1, L. Gieser2, M. Barnes1, A.
Hamon1, C. Masson-Garcia1, M. Perron1, 3. 1CERTO
/ Neuro-PSI, Orsay, France; 2NEI / NIH, Bethesda,
MD; 3CNRS, Orsay, France
3195 — B0295 MicroRNA-124-3p Represses
Retinal Pigment Epithelial Cells Proliferation
and Migration by Targeting RhoG. JongHwa
Jun. Ophthalmology, Dongsan Medical Center,
Keimyung University, Daegu, Korea
(the Republic of)
3196 — B0296 A PAR-ting Gift:
3-Aminobenzamide attenuates PARP-1dependent cell death induced by Melphalan in
a Retinoblastoma cell line. Brittany Townley1, 2,
M. K. Krevosky2, J. Bowen2.1National Cancer
Institute, National Institutes of Health, Bethesda,
MD; 2Biology, Bridgewater State University,
Bridgewater, MA
3197 — B0297 MicroRNA-21 Implicated
in Down-Regulation of PPAR-α in Diabetic
Retinopath. Yusuke Takahashi1, 2, Q. Chen3, 2, F.
Qiu3, E. Moran3, 2, M. H. Greg3, 2, K. Zhou3, R.
V. Rajala3, 4, J. Ma3, 2.1Medicine, University of
Oklahoma Health Sciences Center, Oklahoma
City, OK; 2Harold Hamm Diabetes Center,
Oklahoma City, OK; 3Physiology, University of
Oklahoma Health Sciences Center, Oklahoma City,
OK;4Ophthalmology, University of Oklahoma
Health Sciences Center, Oklahoma City, OK
3198 — B0298 Optical Sensing of Molecular
Structure in Vitreous of Patients with Decreased
Contrast Sensitivity. Matin Khoshnevis1, 2, A.
Sampathkumar4, G. A. Garcia1, 2, J. Sebag1, 3. 1VMR
Institute for Vitreous Macula Retina, Huntington
Beach, CA; 2School of Medicine, University of
California, Irvine, Irvine, CA; 3Ophthalmology,
Doheny Eye Institute/UCLA, Los Angeles, CA;
4
Electromagnetic Sciences, Lizzi Center for
Biomedical Engineering, Riverside Research,
Dayton, OH
3199 — B0299 Investigation of VEGF165
induced retinal vascular inflammation in vitro.
Ashley Mackey, Y. Ng. Ophthalmology, Schepens
Eye Research Institute/Mass Eye and Ear,
Boston, MA
3200 — B0300 Oxidative stress, autophagy, and
exosome liberation in retinal pigment epithelium
cells. Sandra Atienzar, G. Serrano, N. Martinez,
D. López, L. Vidal, N. Morillas, A. Urdaneta, B.
Prieto, J. Barcia, F. Sancho, F. Rómero. Phisiology,
Catholic University of Valencia, Valencia, Spain
Exhibit/Poster Hall C0001-C0038
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Retinal Cell Biology
321 Diabetic Retinopathy
Moderator: Julia V. Busik
3201 — C0001 Photoreceptor distortion
accompanies inner retina degeneration and loss
of visual function in streptozotocin-diabetic rats.
Alistair J. Barber, Z. Nasralah. Ophthalmology,
Penn State Hershey College of Medicine, Hershey, PA
3202 — C0002 Molecular mechanisms
underlying the mechanical control of retinal
endothelial activation associated with diabetes.
Kaustabh Ghosh1, X. Yang1, A. Bhaskaran1, A.
Das2, T. S. Kern3.1Bioengineering, University
of California, Riverside, Riverside, CA;
2
Ophthalmology, University of New Mexico,
Albuquerque, NM; 3Medicine, Case Western
Reserve Univ, Cleveland, OH *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
224
Tuesday – Posters – 3203 – 3224
3203 — C0003 The Role Of Acid
Sphingomyelinase In Shifting The Balance
Between Pro-inflammatory And Reparative Bone
Marrow Cells In Diabetic Retinopathy. Walter
V. Esselman1, H. Chakravarthy2, S. N. Navitskaya2,
S. V. O’Reilly2, E. Beli3, Q. Wang2, N. Kady2, C.
Huang2, M. B. Grant3, J. V. Busik2. 1College of
Human Medicine, Michigan State University,
East Lansing, MI; 2Physiology, Michigan State
University, East Lansing, MI; 3Ophthalmology,
Indiana University, Indianapolis, IN
3211 — C0011 miR15a/16 mediates protective
effects of beta-adrenergic signaling to reduce
leukostasis in diabetic retinopathy. Li Liu, E. Ye,
J. J. Steinle. Anatomy and Cell Biology, Wayne
State University, Detroit, MI
3204 — C0004 A novel role of poly(ADPribose) polymerase 1 in mitochondrial damage
in diabetic retinopathy. Manish Mishra, R. A.
Kowluru. Ophthalmology, Kresge Eye Institute,
Detroit, MI
3213 — C0013 12/15 lipoxygenase and Vascular
Endothelial Growth Factor Signaling in Retinal
Cells. Nehal M. Elsherbiny1, 2, A. Ibrahim1, 2, H.
M. Saleh1, K. Hussein1, K. Elmasry5, N. Sheibani3,
M. A. Al-Shabrawey1, 4. 1Oral Biology and
Anatomy, College of Dental medicine, Augusta
university, Augusta, GA; 2Biochemistry, Faculty of
Pharmacy, Mansoura University, Mansoura, Egypt;
3
Ophthalmology and Visual Sciences, University
of Wisconsin, Madison, WI; 4The Culver Vision
Discovery Institute, Georgia Regents University,
Augusta, GA; 5Cellular Biology and Anatomy,
Medical college of Georgia, Augusta University,
Augusta, GA
3205 — C0005 Effect of Hyperglycemia on
Circadian Rhythm of Human Retinal Vascular
Endothelial Cells. Sankarathi Balaiya, K. Chalam.
Ophthalmology, University of Florida College of
Medicine, Jacksonville, FL
3207 — C0007 Inhibiting VEGF Signaling
by Targeting Receptor Trafficking in Diabetic
Retinopathy. Weiquan Zhu, D. S. Shi, J. Winter, B.
Rich. Department of Internal Medicine, University
of Utah, Salt Lake City, UT
3208 — C0008 The Tumor Necrosis
Factor α (TNF-α) Disturbs Kir4.1 Rhythm
in Muller Cells. Ashay D. Bhatwadekar1, I.
Hassan1, S. Majumdar1, V. Jadhav1, J. V. Busik2.
1
Ophthalmology, Eugene and Marilyn Glick
Eye Institute, Indianapolis, IN; 2Department of
Physiology, Michigan State University, East
Lansing, MI
3209 — C0009 Sphingosine-1-Phosphate
demonstrates anti-angiogenic and antiinflammatory properties. Carolina Franco
Nitta1, 2, F. Monickaraj1, S. Rangasamy4, P.
McGuire3, A. Das1, 2. 1Surgery, University of New
Mexico Health Sciences Center, Albuquerque, NM;
2
Surgery, NMVA Health Care System, Albuquerque,
NM; 3Cell Biology and Physiology, University of
New Mexico Health Sciences Center, Albuquerque,
NM;4Translational Genomics Research Institute,
Phoenix, AZ
3210 — C0010 Possible involvement of
aquaporin 4 and nitric oxide in the high glucoseinduced swelling of Muller cells in rat retina.
Teruyo Kida, H. Oku, M. Fukumoto, Y. Okuda, S.
Morishita, T. Horie, H. Suzuki, T. Kobayashi, T.
Ikeda. Ophthalmology, Osaka Medical College,
Takatsuki, Japan
3214 — C0014 Potential of Human Donor
Tissues for Discovery and Targeted Research on
Diabetic Retinopathy. Patrice E. Fort1, 2, Y. Qi1,
A. Myers1. 1Ophthalmology and Visual Sciences,
University of Michigan, Ann Arbor, MI; 2Molecular
and Integrative Physiology, University of Michigan,
Ann Arbor, MI
3215 — C0015 The relationship between
retinal blood flow, neuronal function and glia
in the early diabetic retina,. Samuel A. Mills1,
A. I. Jobling1, B. V. Bui2, Z. He2, U. Greferath1,
J. Wang2, F. Hui2, E. L. Fletcher1. 1Anatomy and
Neuroscience, The University of Melbourne,
Melbourne, VIC, Australia; 2Optometry and Vision
Science, The University of Melbourne, Melbourne,
VIC, Australia
3216 — C0016 NOX4 Stabilizes Barrier
Function of Human Retinal Endothelial Cells
and Retinal Pigment Epithelial Cells. Heba
M. Saleh1, 2, K. Hussein1, 5, A. S. Ibrahim1, 4, K.
Elmasry3, 2, N. M. El-Sherbiny1, 4, D. Fulton6, 7, M.
A. Al-Shabrawey1, 2. 1Oral Biology and Anatomy,
Dental College of Georgia, Augusta University,
Augusta, GA; 2Culver Vision Discovery Institute
and Ophthalmology, Medical College of Georgia,
Augusta University, Augusta, GA; 3Cellular
Biology and Anatomy, Medical College of Georgia,
Augusta University, Augusta, GA; 4Biochemistry
Department, Faculty of Pharmacy, Mansoura
University, Mansoura, Egypt; 5Oral and Dental
Research Division, Department of Surgery and
Medicine, National Research Center, Cairo,
Egypt; 6Vascular Biology Center, Medical College
of Georgia, Augusta University, Augusta, GA;
7
Pharmacology and Toxicology, Medical College of
Georgia, Augusta University, Augusta, GA
3218 — C0018 Elevated homocysteine in
the vitreous of diabetic patients and blood of
type 1 and 2 diabetic animal models; Potential
role of homocysteine in blood retinal barrier
dysfunction. Isha Sharma, A. S. Ibrahim, H. M.
Saleh, S. Rizwan, G. I. Liou, M. A. Al-Shabrawey, A.
M. Tawfik. augusta university, Augusta, GA
3219 — C0019 Activated Monocytes
Contribute to the Mechanical Control of Diabetic
Retinal Endothelial Activation. Arun Bhaskaran,
X. Yang, H. Scott, K. Ghosh. Department of
Bioengineering, University of California, Riverside,
Riverside, CA
3220 — C0020 Rho/ROCK-mediated Retinal
Endothelial Stiffening Impairs TRPV4 Signaling
and Promotes Diabetic Retinal Inflammation.
Xiao Yang1, A. Bhaskaran1, H. Scott1, S. Ardekani1,
J. Xu2, U. Mohideen2, T. S. Kern3, K. Ghosh1.
1
Bioengineering, University of California,
Riverside, Riverside, CA; 2Physic, University of
California, Riverside, Riverside, CA; 3Case Western
Reserve University, Cleveland, OH
3221 — C0021 Measurement of acute vascular
permeability and associated signaling in ex
vivo rat retinae. Eleni Karatsai, M. B. Powner, S.
Dragoni, P. Turowski. UCL, London,
United Kingdom
3222 — C0022 Detailed quantitative and
qualitative evaluation of potential ganglion cell
pathology in the retina of Zucker Diabetic Fatty
(ZDF) Rats. Akos Lukats1, K. Szabo1, A. Enzsoly1, 2,
A. Szabo1, A. Szel1, B. Dekany1, G. M. Somfai2, K.
Laurik2, 1, T. Radovits3, C. Matyas3, R. I. Hajdu1, 2.
1
Human Morphology and Developmental Biology,
Semmelweis University, Budapest, Hungary;
2
Department of Ophthalmology, Semmelweis
University, Budapest, Hungary; 3Heart Center,
Semmelweis University, Budapest, Hungary
3223 — C0023 Up-regulation of SLC2A9
(Glut9) in normal and diabetic human retina
implicates altered urate transport in diabetesinduced retinal barrier dysfunction. Manuela
Bartoli1, D. Gutsaeva1, M. Thounaojam1, P. M.
Martin2, F. Lamoke2. 1Ophthalmology, Medical
College of Georgia -Augusta University, Augusta,
GA; 2Biochemistry and Molecular Biology, Medical
College of georgia-Augusta University, Augusta, GA
3224 — C0024 Blockade of NOX2 or arginase
prevents diabetes-induced retinal endothelial
cell senescence by restoring NO bioavailability.
Modesto Rojas1, 2, T. Lemtalsi1, 2, H. A. Toque3,
Z. Xu1, 2, E. Shosha1, 2, D. Fulton1, R. Caldwell3,
R. B. Caldwell1, 2. 1Vascular Biology Center,
Augusta University, Augusta, GA; 2Research,
Veterans Affairs Medical Center, Augusta, GA;
3
Pharmacology and Toxicology, Augusta University,
Augusta, GA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
225
Tuesday Posters
8:30 am – 10:15 am
3206 — C0006 Aerobic exercise protects
retinal function in type 2 diabetic mice. Mamoru
Kamoshita, H. Osada, E. Toda, K. Sano, M.
Kawashima, N. Nagai, H. Shinoda, K. Tsubota, Y.
Ozawa. Ophthalmology, Keio University School of
Medicine, Shinjuku, Japan
3212 — C0012 Epac1 is required for BetaAdrenergic Receptor Regulation of VEGF
in Retinal Endothelial Cells Grown in High
Glucose. Youde Jiang, J. J. Steinle. Wayne State
University, Detroit, MI
3217 — C0017 Barrier function studies of
VEGF and ANG-2 in human endothelial cells.
Guido Hartmann. Roche Innovation Center Basel,
Hoffman La Roche, Basel, Switzerland *CR
3225 – 3242 – Tuesday – Posters
3225 — C0025 Loss of thioredoxin reductase-1
in the hyperglycemic milieu stimulates retinal
vessel senescence and senescence-associated proinflammatory phenotype. Menaka Thounaojam1,
F. Lamoke2, D. Gutsaeva1, W. Jahng3, P. M. Martin2,
M. Bartoli1. 1Opthalmology, Georgia Regents
University, Augusta, GA; 2Biochemistry and
Molecular Biology, Georgia Regents University,
Augusta, GA; 3Organic Chemistry, Biochemistry,
American University of Nigeria, Yola, Nigeria
3226 — C0026 Regulation of retinal blood
barrier by TNF alpha convertase, ADAM17, and
its implication in diabetic macular edema. Diana
Gutsaeva1, K. Hussein1, F. Lamoke1, H. Kwok2, A.
Solomon3, P. M. Martin1, M. A. Al-Shabrawey1, M.
Bartoli1. 1Georgia Regents University, AUGUSTA,
GA; 2University of Macau, Macau, Macao;
3
Allosterix-Pharma, Moshav-Shilat, Israel *CR
Tuesday Posters
8:30 am – 10:15 am
3227 — C0027 Pharmacological inhibition
of STAT3 suppresses pathologic retinal neovascular growth in the mouse model of oxygeninduced retinopathy. Jose R. Hombrebueno, A.
Lynch, G. Obasanmi, M. Chen, H. Xu. Centre for
Experimental Medicine, Queen’s University Belfast,
Belfast, United Kingdom
3228 — C0028 Effects of erythropoietin
on glucose induced exacerbation of hypoxic
damage in cultured photoreceptor-like cells.
Christopher J. Layton1, 2, C. S. Kawai1, G. de
Moraes3, K. Jenkins1, A. Y. Goh1. 1School of
Medicine, University of Queensland, Brisbane,
QLD, Australia; 2Ophthalmology Research Unit,
Gallipoli Medical Research Institute, Brisbane,
QLD, Australia; 3Faculdade de Medicina de Marília,
Marila, Brazil
3229 — C0029 Tip/Stalk cell behaviour
in endothelial HUVEC monolayers. Elmira
Jalilian1, M. Fruttiger1, P. Coffey2. 1Cell biology,
UCL institute of Ophthalmology, London, United
Kingdom; 2Ocular Biology & Therapeutics, UCL
Institute of Ophthalmology, London,
United Kingdom *CR
3230 — C0030 Exosomes Released From
Human Retinal Endothelial Cells Upon 15HETE Treatment or ER Stress Induction:
Potential Role of Nanoparticles in Diabetic
Retinopathy. Khaled Elmasry1, 2, K. Hussein3, 4, H.
M. Saleh3, 6, A. S. Ibrahim3, 5, N. M. El-Sherbiny3, 5, I.
Helwa1, Y. Liu1, 6, M. A. Al-Shabrawey3, 6. 1Cellular
Biology and Anatomy, Medical College of
Georgia at Augusta University, Augusta, GA;
2
Human Anatomy and Embryology, Faculty
of Medicine, Mansoura University, Mansoura,
Egypt; 3Oral Biology, Dental college of Georgia
at Augusta University, Augusta, GA; 4Surgery and
Medicine, Oral and Dental Research Division,
National Research Center, Cairo, Egypt; 5Clinical
Biochemistry, Faculty of Pharmacy, Mansoura
University, Mansoura, Egypt; 6Culver Vision
Discovery Institute and Ophthalmology, Augusta, GA
3231 — C0031 Intermittent fasting prevents
diabetic retinopathy by correcting the circadian
clock and affecting monocyte infiltration and
inflammation in the retina. Eleni Beli1, Y. Yan2,
L. Moldovan1, T. Salazar1, Y. Duan3, P. Hu1, E.
Hutchinson1, S. Hindi5, J. V. Busik4, M. B. Grant1.
1
Ophthalmology, Indiana University School
of Medicine, Indianapolis, IN; 2MD Anderson
Cancer Center, University of Texas, Houston,
TX;3Physiology, Indiana University School of
Medicine, Indianapolis, IN; 4Physiology, Michigan
State University, East Lansing, MI; 5Chemistry,
IUPUI, Indianapolis, IN
3232 — C0032 Neuroprotective role of GDNF
and BDNF in diabetic retinopathy. Yun-Zheng
Le, M. L. Zhu. Medicine, Cell Biology, and
Ophthalmology, and Harold Hamm Oklahoma
Diabetes Center, Univ of Oklahoma Hlth Sci Ctr,
Oklahoma City, OK
3238 — C0038 Microscopic study of surgically
excised vitreoretinal membranes. Rino Frisina1,
E. Zampedri2, E. zampedri1, F. Tessarolo1, F.
Piccoli3, E. Bonomi4, P. Caciagli3, G. Nollo4, F.
Romanelli1.1Multizonal Unit of Ophthalmology of
Autonomous Province of Trento, Rovereto, Trento,
Italy; 2Depatment of Neurological and Movement
Sciences, AOUI Verona, University of Verona Eye
Clinic, Verona, Italy; 3Department of Laboratory
Medicine, Azienda Provinciale per i Servizi
Sanitari, Trento, largo Medaglie d’oro 9, Trento,
Italy, Italy; 4Healthcare Research and Innovation
Program (IRCS-PAT), Bruno Kessler Foundation,
Trento, Italy
Exhibit/Poster Hall C0039-C0086a
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Retina
3233 — C0033 Integrin Expression in Cultured
Retinal Endothelial Cells and Retinal Pericytes.
Andrew T. Tsin, R. Moritz, S. Vellanki, R. LeBaron.
Biology, University of Texas San Antonio,
San Antonio, TX
322 Diabetic retinopathy and steroids
3234 — C0034 Regulatory mechanisms of
the neuroprotective function of αA- and αBcrystallins in retinal neurons and glia. Anne
Ruebsam, M. Losiewicz, J. Jiang, P. E. Fort.
Departments of Ophthalmology and Visual
Sciences, Kellogg Eye Center, University of
Michigan, Ann Arbor, MI
3239 — C0039 The presence of diabetic
macular edema in patients with new onset
vitreous hemorrhage associated with
proliferative diabetic retinopathy. J. Brown1, 2,
J. Brown1, 2, Jeremiah Brown1, 2.1Retina, Brown
Retina Institute, San Antonio, TX; 2Ophthalmology,
University of Texas Health Science Center, San
Antonio, San Antonio, TX *CR
3235 — C0035 Systematic Analysis of
the Effects of Diabetes-Relevant Stimuli
on Endothelial Expression of Extracellular
Matrix Constituents. Meredith J. Giblin, J. S.
Penn. Department of Ophthalmology and Visual
Sciences, Vanderbilt University School of Medicine,
Nashville, TN *CR
3236 — C0036 Muller cells treated with alpha 1
antitrypsin (AAT) in vitro showed less expression
of VEGF and IL6. Gustavo Ortiz, J. E. Gallo.
Ophthalmology, Universidad Austral,
Pilar, Argentina
3237 — C0037 Diverse Actions of Interleukin-6
on Human Müller Versus Human Retinal
Endothelial Cells Under Hyperglycemic
Conditions. Brandon Coughlin, D. J. Feenstra, S.
Mohr. Department of Physiology, Michigan State
University, East Lansing, MI
Moderators: James C. Folk, Young Hee Yoon and
Baruch D. Kuppermann
3240 — C0040 Short Term Results of
Fluocinolone Acetonide Intravitreal Implant
(Iluvien®) for Diabetic Macular Edema in Highly
Treated Eyes. Nisha Dhawlikar1, S. P. Shah1, 2, D.
L. Yarian1, 2, J. L. Prenner1, 2, E. S. Friedman1, 2,
H. F. Fine1, 2, H. M. Wheatley1, 2, D. B. Roth1, 2.
1
Rutgers - Robert Wood Johnson Medical School,
New Brunswick, NJ; 2NJ Retina, New Brunswick,
NJ *CR
3241 — C0041 Statistical modeling to predict
initial treatment response to Ozurdex for
diabetic macular edema. Karishma Habbu1, 2,
R. Singh1, S. Srivastava1, F. Silva1, P. K. Kaiser1,
A. Babiuch1, C. Al-Dhubaib3. 1Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 2Case Western
Reserve School of Medicine, Cleveland, OH;
3
Triple Analytics, Cleveland, OH *CR
3242 — C0042 Retinal inter vascular arcade
area and susceptibility to diabetic maculopathy.
Randev Mendis1, R. Chakrabarti2, Q. Findlay3.
1
Canberra Retina Clinic, Canberra, ACT, Australia;
2
Victoria Eye and Ear Hospital, Melbourne, VIC,
Australia; 3The Canberra Hospital, Canberra, ACT,
Australia
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
226
Tuesday – Posters – 3243 – 3262
3243 — C0043 Integrity of Outer Retinal
Layers After Resolution of Central Involved
Diabetic Macular Edema. Ilkay Kilic Muftuoglu2, 1,
N. Mendoza2, R. Gaber2, M. Ragheb2, Q. You2,
W. R. Freeman2. 1Ophthalmology, Istanbul
Training And Research Hospital, Istanbul, Turkey;
2
Ophthalmology, University Of California
San Diego, San Deigo, CA
3244 — C0044 Prospective study to evaluate
the safety of Dexamethasone Intravitreal
Implant in Diabetic Macular Edema. Silvio Di
Monaco, S. Berteramo, N. Delle Noci, C. Iaculli.
Department Of Ophthalmology, Institute Of
Ophthalmology-Policlinico Di Foggia-Italy,
Foggia, Italy
3245 — C0045 Role of Soluble Vascular
Endothelial Growth Factor Receptor Signaling
and Other Factors or Cytokines in Diabetic
Macular Edema. Hidetaka Noma, K. Yasuda,
M. Shimura. Ophthalmology, Tokyo Medical
University Hachioji Medical Center, Tokyo, Japan
3247 — C0047 Subthreshold laser grid
photocoagulation for the treatment of diabetic
macular edema. Pietro Frascio, R. Rosa, D.
Musetti, M. Musolino, C. Cutolo, C. E. Traverso, M.
Nicolo. Clinica Oculistica Genova, Genova, Italy
3248 — C0048 Ocular photostimulation
with the 577 nm micropulse yellow laser in the
management of clinically significant diabetic
macular edema (CSDME) - 2nd Year of Followup. Ezio Cappello1, E. Cecchin1, A. Toso1, S.
Morselli1, G. Dorin2. 1Ophthalmology, Ospedale
San Bassiano - Bassano del Grappa, Bassano del
Grappa, Italy; 2Eyengineering Inc., Ojai, CA *CR
3249 — C0049 Reduced efficacy of intravitreal
dexamethasone implant in diabetic macular
edema with subfoveal cystoid spaces. Hae Jung
Sun, S. Lee. Ophthalmology, Soonchunhyang
University Hospital, Seoul, Korea (the Republic of)
3250 — C0050 Potential Beneficial Effect
of Low Dose Danazol in Combination With
Renin Angiotensin System Inhibitors in
Diabetic Macular Edema: a 12-week Double
Blind Randomized Controlled Trial. Michael
Singer1, A. Orlando2, 3, V. Clift4, D. Bar-Or4, 2.
1
Med Ctr Ophthalmology Assoc, San Antonio,
NY; 2Trauma Research, Swedish Medical Center,
Englewood, CO; 3Trauma Research, St. Anthony
Hospital, Lakewood, CO; 4Ampio Pharmaceuticals,
Englewood, CO *CR, f
3252 — C0052 Hyperreflective Retinal Spots
in Diabetic Eyes with and without Diabetic
Macular Edema: B-Scan and en-face Spectral
Domain Optical Coherence Tomography
Evaluation. Edoardo Midena1, 2, S. Bini1, T.
Torresin1, F. Martini1, P. Pucci1, A. Daniele1, R.
Parrozzani2, O. Kotsafti2, S. Vujosevic1. 1University
of Padova, Padova, Italy; 2GB Bietti Foundation,
IRCCS, Roma, Italy
3253 — C0053 Twelve-month treatment with
intravitreal dexamethasone implant for diabetic
macular edema. Valentina Sarao1, 2, D. Veritti1, 2,
P. Lanzetta1, 2. 1Medical and Biological Sciences Ophthalmology, University of Udine, Udine, Italy;
2
Istituto Europeo di Microchirurgia Oculare-IEMO,
Udine, Italy *CR
3254 — C0054 Macular volume is better than
central foveal thickness measured by SD-OCT
for the detection of moderate and severe macular
edema. David Rivera1, 2, A. Jimenez-Corona1,
L. Perez-Peralta1, 2, S. Cardenas-Gonzalez1, E.
O. Graue-Hernandez1. 1Medicine, Institute of
Ophthalmology Fundación Conde De Valenciana,
Mexico City, Mexico; 2Centro de Atención Integral
del Paciente con Diabetes, Instituto Nacional De
Ciencias Médicas y Nutrición Salvador Zubirán,
Mexico, Mexico
3255 — C0055 Dexamethasone implant with
fixed or individualized regimen in the treatment
of diabetic macular edema: the UDBASA study.
Paolo Lanzetta4, 1, D. Veritti4, 1, V. Sarao4, 1, E.
Giancipoli2, F. Boscia2, C. Furino3, G. Alessio3.
1
Istituto Europeo di Microchirurgia Oculare-IEMO,
Udine, Italy; 2Department of Ophthalmology,
University of Sassari, Sassari, Italy; 3Department of
Basic Medical Sciences, Neuroscience, and Sense
Organs, University of Bari-Policlinico, Bari, Italy;
4
Department of Medical and Biological Sciences Ophthalmology, University of Udine, Udine, Italy
*CR, f
3256 — C0056 Safety and Efficacy of
Intravitreal Ocriplasmin in Diabetic Macular
Edema with Vitreomacular Adhesion. Bernardete
Pessoa1, J. Coelho1, 2, S. Monteiro1, N. Ferreira1,
J. Melo Beirão1, 3, A. Meireles1, 3. 1Ophtalmology,
Centro Hospitalar do Porto, Porto, Portugal;
2
Physiology and Cardiothoracic surgery, Faculdade
de Medicina da Universidade do Porto, Porto,
Portugal; 3Neuroscience, Instituto de Ciências
Biomédicas Abel Salazar, Porto, Portugal *CR
3257 — C0057 Preliminary results from the
RESPOND trial: Investigator-driven study in
Portugal to evaluate real-life safety and efficacy
of ILUVIEN in patients with chronic DME. Joao
Figueira1, 2, M. Amaro3, J. Henriques4, V. Rosas5.
1
CEC, AIBILI, Coimbra, Portugal; 2Ophthalmology
Department, Coimbra University Hospital,
Coimbra, Portugal; 3Ophthalmology Department,
Hospital Vila Franca de Xira, Vila Franca de Xira,
Portugal; 4Instituto de Retina e Diabetes Ocular
de Lisboa, Lisboa, Portugal; 5Ophthalmology
Department, Centro Hospitalar de São João, Porto,
Portugal *CR, f
3258 — C0058 Clinical effectiveness of the
fluocinolone acetonide implant in diabetic
macular oedema resistant to anti-VEGF therapy.
Spyridon E. Chalkiadakis1, 2, F. J. Harris1, 2, S.
Taylor1, 2.1Ophthalmology, University Of Surrey,
Guildford, United Kingdom; 2Ophthalmology,
Royal Surrey County Hospital, Guilford,
United Kingdom
3259 — C0059 Real-World Assessment of
Dexamethasone Intravitreal Implant in Diabetic
Macular Edema: Interim Analysis from the
REINFORCE Study. Howard F. Fine1, M. Singer2,
P. U. Dugel3, A. Capone, Jr.4, J. Maltman5. 1Rutgers
UMDNJ Dept Ophthalmology, NJ Retina, New
Brunswick, NJ; 2University of Texas Health Science
Center, San Antonio, TX; 3Retinal Consultants
of Arizona, Phoenix, AZ; 4Associated Retinal
Consultants, Royal Oak, MI; 5Allergan plc,
Irvine, CA *CR, f
3260 — C0060 Oral kalliginogenase improved
chorioretinal blood flow levels and significantly
reduced subfoveal choroidal thickness in
diabetic macular edema patients. Eiko Tsuiki1,
K. Suzuma1, 2, Y. H. Mohamed1, Y. Yamada1, M.
Matsumoto1, T. Kitaoka1. 1Ophthalmology and
Visual Sciences, Graduate School of Biomedical
Sciences, Nagasaki University, Nagasaki, Japan;
2
Ophthalmology and Visual Sciences, Kyoto
University, Kyoto, Japan f
3261 — C0061 Variations Of The Diabetic
Macular Edema After Cataract Surgery On
Patients Being Treated With NSAIDs And/Or
Resveratrol Supplements. Luigi Zompatori, E.
Sterbini, R. Salvati, S. Altimari. Tivoli Hospital,
Tivoli, Italy
3262 — C0062 Variations in the size of retinal
cysts as a tomographic factor predictor for
retreatment with Ozurdex in patients with
refractory diabetic macular edema. Félix
Alexander Manco Lavado1, 2, M. Ramoa Osorio1, 2,
M. Lopez1, 2, L. Manzanas Leal1, 2, I. Alonso de la
Fuente1, 2, M. Hernando Verdugo3. 1Ophthalmology,
Hospital Clinico Universitario, Valladolid, Spain;
2
Ophthalmology, IOBA (University of Valladolid),
Valladolid, Spain; 3Pharmacy, Hospital Clinico
Universitario, Valladolid, Spain
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
227
Tuesday Posters
8:30 am – 10:15 am
3246 — C0046 Indocyanine green-guided
targeted photocoagulation of macroaneurysms
in macular edema: a pilot study. Benedicte M.
Dupas1, E. Philippakis1, S. meimon2, C. Bonnet3,
J. GIRMENS3, M. Paques3. 1Hospital Lariboisiere,
Paris, France; 2Office National d’Etudes et de
Recherches Aéronautiques, Département d’Optique
Théorique et Appliquée (ONERA-DOTA, Chatillon,
France; 3Clinical Investigation Center 1423,
Quinze-Vingts Hospital, INSERM & Université
Pierre et Marie Curie-Paris, Paris, France
3251 — C0051 Identification of AntiHexokinase-1 Antibody in the Sera from Patients
with Diabetic Macular Edema. Tatsuya Yoshitake,
T. Murakami, K. Suzuma, S. Yoshitake, A. Uji, M.
Fujimoto, Y. Miwa, N. Yoshimura. Ophthalmology
and Visual Sciences, Kyoto University Graduate
School of Medicine, Kyoto, Japan *CR
3263 – 3284 – Tuesday – Posters
3263 — C0063 Efficacy and safety of
dexamethasone intravitreal implant for diabetic
macula edema in clinical practice: real-world
results. Brian Savoie, J. Jonisch. Ophthalmology,
North Shore Long Island Jewish Health System,
Bellerose, NY
3264 — C0064 Visit Adherence in Diabetic
Macular Edema Patients. Neepa Shah, L.
Kanu, N. Fuerst, M. Lau, D. Dao, E. Atkinson,
B. L. VanderBeek. Ophthalmology, University of
Pennsylvania, Philadelphia, PA
Tuesday Posters
8:30 am – 10:15 am
3265 — C0065 Early effects of intravitreal
steroid on severe diabetic macular edema:
morphological and functional features. Simona
Maria Caprani1, S. Donati1, J. Cattaneo1, M.
Mazzola1, L. Premoli1, M. Bianchi1, Z. Stefano1, M.
Romano2, S. Gandolfi3, F. Semeraro4, C. Azzolini1.
1
Department of Surgical and Morphological
Sciences - Section of Ophthalmology, University
of Insubria, Varese, Italy; 2Ophthalmology Clinic,
University of Napoli, Napoli, Italy; 3Ophthalmology
Clinic, University of Parma, Parma, Italy;
4
Ophthalmology Clinic, University of Brescia,
Brescia, Italy
3270 — C0070 Novel Serum Cytokines and
Chemokines in Diabetic Macular Edema. Finny
Monickaraj1, C. Franco Nitta1, 2, P. McGuire3, A.
Das1, 2. 1Surgery/Ophthalmology, University of
New Mexico School of Medicine, Albuquerque,
NM; 2New Mexico VA Health Care System,
Albuquerque, NM; 3Cell Biology & Physiology,
University of New Mexico School of Medicine,
Albuquerque, NM
3277 — C0077 Does the Vitreous Protect
the Retina, Vasculature, and Optic Nerve
from Impact During Intravitreal Injection of
Dexamethasone Implants? Stavros N. Moysidis1,
N. Koulisis1, L. C. Olmos1, A. A. Moshfeghi1, N.
A. Rao1, M. S. Humayun1, 2, D. C. Rodger1. 1USC
Eye Institute, University of Southern California,
Los Angeles, CA; 2USC Institute for Biomedical
Therapeutics, Los Angeles, CA *CR
3271 — C0071 Quantitative evaluation of
hard exudates in diabetic macular edema after
intravitreal injection of steroid and anti-vascular
endothelial growth factor. Yong Un Shin, H. Cho,
H. Lim, S. Park, E. Hong. Ophthalmology, Hanyang
University Guri Hospital, Gyeonggi-do, Korea
(the Republic of)
3278 — C0078 Precision Size and Shape
Extended Release Intravitreal Dexamethasone
Implants. Sanjib K. Das, S. Williams, J. Tully,
R. S. Verhoeven, M. Yang, T. Navratil, R.
Schiffman. Implantable implant Research, Envisia
Therapeutics, Morrisville, NC
3272 — C0072 The outcome of chronic
diabetic macular oedema in patients treated with
intravitreal Fluocinolone acetonide (Iluvien).
Ibraheem El-Ghrably. Ophthalmology, James Cook
University Hospital, Newcastle Upon-Tyne,
United Kingdom *CR
3266 — C0066 Role of Vascular Changes in
Diabetic Cystoid Macular Edema: An Optical
Cohorens Tomography (OCT)-based study.
Ata Baytaroğlu1, A. Agin1, Y. Çevik2, U. Acar1, G.
Sobaci1.1Ophthalmology, Hacettepe University,
Ankara, Turkey; 2Ophthalmology, Ardahan State
Hospital, Ardahan, Turkey
3273 — C0073 A retrospective evaluation of
the efficacy and safety of fluocinolone acetonide
0.2 μg implant in patients with chronic diabetic
macular edema with insufficient response to
other therapies.Angelina Meireles1, 2, J. Coelho1,
B. Pessoa1. 1Ophthalmology, Centro Hospitalar do
Porto - HSA, Porto, Portugal; 2Medicine Faculty,
Abel Salazar Biomedical Sciences Institute,
Porto, Portugal
3267 — C0067 Pro-permeability Factors in
Diabetic Macular Edema; the Diabetic Macular
Edema Treated with Ozurdex (DMEO) Trial.
Tahreem A. Mir, A. Scott, L. He, R. Channa, C.
Mayerle, J. T. Handa, S. A. Kherani, Y. S. Han, G.
Wang, J. Qian, P. A. Campochiaro. The Wilmer
Eye Institute, Johns Hopkins University School of
Medicine, Baltimore, MD *CR, f
3274 — C0074 Dexamethasone implant in
diabetic macular edema patients with high
visual acuity. Riccardo Sacconi1, M. Battaglia
Parodi2, S. Casati1, R. Lattanzio2, F. Bandello2,
G. Marchini1.1Ophthalmology Unit, University
of Verona, AOUI, Verona, Italy; 2Ophthalmology,
University Vita-Salute, Scientific Institute San
Raffaele, Milano, Italy *CR
3268 — C0068 Repeatability and
reproducibility of retinal and choroidal thickness
measurements in Diabetic Macular Edema using
Swept-source Optical Coherence Tomography.
Anna Sala-Puigdollers, J. Zarranz-Ventura,
M. Figueras-Roca, M. Hereu, T. Hernandez,
M. Morató, M. Mesquida, V. Llorens, M. Sainz
de la Maza, A. Adan Civera. Department of
Ophthalmology, Hospital Clínic de Barcelona,
Barcelona, Spain
3275 — C0075 Qualitative and quantitative
analysis of retinal vascular impairment in
Diabetic Maculopathy: an OCT-Angiography
assessment. Gabriel J. Coscas2, 1, M. Lupidi3, 2,
F. Tito3, C. Cagini3, F. Coscas2, 1. 1Department
of Ophthalmology, Creteil Eye Clinic Univ
Hospital, Creteil, France; 2Centre Ophtalmologique
De L’Odeon, Paris, France; 3Department of
Biochemical and Surgical Sciences, Section of
Ophthalmology, University of Perugia, Perugia, Italy
3269 — C0069 Trends in diabetic macular
edema therapy at a single academic institution.
Levi N. Kanu1, N. Shah1, N. Fuerst1, M. Lau1, E.
Atkinson1, D. Dao1, B. L. VanderBeek1, 2. 1Scheie
Eye Institute, Department of Ophthalmology,
Perelman School of Medicine at the University of
Pennsylvania, Philadelphia, PA; 2Center for Clinical
Epidemiology and Biostatistics, Perelman School
of Medicine at the University of Pennsylvania,
Philadelphia, PA
3276 — C0076 Modifications of Retinal
Inflammatory Biomarkers after Intravitreal
Steroid and anti-VEGF Treatment in Diabetic
Macular Edema. Stela Vujosevic1, T. Torresin1,
S. Bini1, M. Berton1, F. Martini1, P. Pucci1, A.
Daniele1, E. Midena1, 2. 1Ophthalmology, University
of Padova, Padova, Italy; 2G.B. Bietti Foundation,
IRCCS, Rome, Italy
3279 — C0079 Early intravitreal triamcinolone
acetonide for persistent diabetic macular edema
after vitrectomy. Masahiko Sugimoto, M. Kondo,
A. Ichio. Ophthalmology, Mie University School of
Medicine, Tsu, Japan f
3280 — C0080 Diabetic macular edema
treatment management by french retinal
specialists. Lise Qu1, F. Fajnkuchen1, 2, G. Chaine1,
A. Giocanti1. 1CHU d’Avicenne, Paris, France;
2
Centre Ophtalmologique d’Imagerie et de Laser,
France, Paris, France *CR
3281 — C0081 Clinical management of
diabetic macular edema by retina specialists in
clinical practice in Spain: OBSERVAR Study.
Beatriz Romero1, A. Pareja3, M. Abraldes2, M.
Roura1. 1Novartis Pharma, Barcelona, Spain;
2
Complexo Hospitalario Universitario de Santiago
de Compostela, Santiago de Compostela, Spain;
3
Hospital Universitario de Canarias, Tenerife, Spain
*CR
3282 — C0082 Change in retinal function
and morphology in patients with Diabetic
macular edema switching from anti-VEGF to
steroid (Fluocinolone acetonide). Radha Das,
U. Chakravarthy. School of Medicine, Queens
University, Belfast, BELFAST, United Kingdom *CR
3283 — C0083 Sustained Intraocular Delivery
of Fluocinolone Acetonide Slows Progression of
Diabetic Retinopathy. Peter A. Campochiaro1, C.
C. Wykoff2, B. Kapik3, K. E. Green3. 1Surgery, Johns
Hopkins Wilmer Eye Inst, Baltimore, MD; 2Retina
Consultants of Houston, Houston, TX; 3Alimera
Sciences, Inc., Alpharetta, GA *CR, f
3284 — C0084 Incidence and risk factor
of elevated intraocular pressure after
dexamethasone intravitreal implant. Jiwoong
Lee, H. Lim. Ophthalmology, Pusan National
University, Busan, Korea (the Republic of)
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
228
Tuesday – Posters – 3285 – 3303
3285 — C0085 Ocular Safety of Intravitreal
Anti Connective Tissue Growth Factor
Neutralizing Antibody. Narsis Daftarian1, 2, T.
Motevasseli1, A. Bagheri2, 3, M. Rezaeikanavi2,
H. Ahmadieh1, 2, Z. Soheili4. 1Ophthalmology,
Ophthalmic Research Center, SBMU, Tehran, Iran
(the Islamic Republic of); 2Ophthalmology, Ocular
Tissue Engineering Research Center, SBMU,
Tehran, Iran (the Islamic Republic of); 3Genetics,
3-University of Social Welfare and Rehabilitation
Sciences, Tehran, Iran (the Islamic Republic
of); 4Genetics, 4- National Institute of Genetic
Engineering and Biotechnology, Tehran, Iran (the
Islamic Republic of)
3286 — C0086 Substained intraocular
hypertension or steroids-induced Glaucoma
after dexamethasone implant (DEX implant)
intravitreal injection, myth or reality? Amina
Rezkallah1, L. Kodjikian1, A. Macles2, H. El
Chehab2, A. Vie1, E. Agard2, A. NGuyen1, C. Dot2.
1
Hôpital de la Croix Rousse, Lyon, France; 2Hôpital
d’instruction des armées Desgenettes, Lyon, France
Exhibit/Poster Hall D0029-D0062
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Immunology/Microbiology / Glaucoma
323 Inflammation / Infection/ Imaging /
Non infectious Uveitis
Moderators: Philip I. Murray and Richard W. Lee
3287 — D0029 Diagnostic evaluation of
RTVue-100 fourier-domain corneal anterior
module OCT system in uveitic eyes of various
etiologies. Noriyasu Hashida, S. Koh, T. Soma,
Y. Oie, N. Maeda, K. Nishida. Department of
Ophthalmology, Osaka University Graduate School
of Medicine, Suita, Japan f
3288 — D0030 A comparison of ocular syphilis
phenotypes between HIV-Infected and nonHIV adult patients. Yan Yee Hah1, S. Yap1, S.
Ho1, S. Teoh1, 2, R. V. Agrawal1. 1Ophthalmology
Department, Tan Tock Seng Hospital, Singapore,
Singapore; 2Eagle Eye Centre, Singapore,
Singapore *CR
3289 — D0031 Prophylactic and therapeutic
effects of oral administration of transgenic rice
on birch pollen-induced allergic conjunctivitis
in mice. Waka Ishida1, K. Fukuda1, L. Yang2, F.
Takaiwa2, A. Fukushima1. 1Ophthalmology, Kochi
Medical School, Nankoku, Japan; 2Functional
Transgenic Crop Research Unit, National Institute
of Agrobiological Sciences, Tsukuba, Japan
3291 — D0033 Second harmonic generation
imaging of corneal stroma after infection
by Pseudomonas aeruginosa. Danielle M.
Robertson, M. Petroll. Ophthalmology, Univ Texas
Southwestern Medical Ctr, Dallas, TX
3292 — D0034 Clinical features and Seasonal
Variation of HLA B27 positive associated
anterior uveitis in an Argentine Tertiary
University Hospital. Mariana Ingolotti1, M.
S. Ormaechea1, J. Fernandez1, M. Portela1, A.
Lupinacci1, C. A. Couto2, M. J. Saravia1, B. A.
Schlaen1. 1Hospital Universitario Austral, Pilar,
Argentina; 2Hospital de Clinicas, Capital Federal,
Argentina
3293 — D0035 The Herpes Simplex Virus LAT
Gene is Associated with a Broader Repertoire of
Virus-Specific Exhausted CD8+ T Cells Retained
within the Trigeminal Ganglia of Latently
Infected HLA Transgenic Rabbits. Lbachir
BenMohamed, A. Khan, R. Srivastava, S. Wechsler,
A. B. Nesburn. Gavin Herbert Eye Institute,
University of California Irvine, Irvine, CA
3294 — D0036 Beta-glucan modulates Th2
immune response by inducing IL-10+ CD4 T
cells in allergic conjunctivitis. Hyun Soo Lee1, J.
Kwon1, C. Rho2, C. Joo1. 1Seoul St.Mary Hospital,
Seoul, Korea (the Republic of); 2Ophthalmology,
Daejeon St. Mary’s Hospital, Daejeon, Korea
(the Republic of)
3295 — D0037 Serum lipopolysaccharide
levels are associated with disease activity of the
oral mucous membrane in Behçet’s Disease. L.
Low1, Liying Low1, L. Morton1, G. R. Wallace1, D.
Situnayake2, S. Rauz1, P. I. Murray1. 1Academic
Unit of Ophthalmology, University of Birmingham,
Birmingham, United Kingdom; 2Rheumatology
Department, Behçet’s Syndrome National Centre of
Excellence, Birmingham, United Kingdom
3296 — D0038 Variable clinical course of
cytomegalovirus anterior uveitis in Japanese
patients. Yosuke Harada, K. Fukuda, A. Nakahira,
K. Tada, T. Sumi, A. Fukushima. Development
Dept., Kochi Medical School, Nankoku, Japan
3297 — D0039 Involvement of NETosis in
LPS-induced ocular inflammation in a mouse
model. Tilda Barliya1, 2, D. Rima3, Y. Nisgav1, 2,
M. Dachbash1, 2, D. Gaton1, 4, G. Kenet3, 4, D.
Weinberger1, 4, T. Livnat2, 3. 1Rabin Medical Center,
Petach Tikva, Israel; 2Felsenstein Medical Research
Center (FMRC), Petach Tikva, Israel; 3The Israeli
National Hemophilia Center, Sheba Medical Cener,
Ramat Gan, Israel; 4Sackler School of Medicine,
Tel-Aviv University, Tel-Aviv, Israel
3298 — D0040 Naïve retina-specific T cells
provide neuroprotection to retinal ganglion
cells in mouse models of glaucoma. Jennifer L.
Kielczewski1, R. Horai2, R. R. Caspi2. 1Laboratory of
Immunology & Imaging Core, NEI/NIH, Bethesda,
MD; 2Laboratory of Immunology, NEI/NIH,
Bethesda, MD
3299 — D0041 The rd8 mutation in the
Crumbs1 gene upregulates activation markers on
retinal and brain microglia and CD11c-eYFP+
cells. Samantha Dando1, C. Naranjo-Golborne1,
H. Chinnery2, M. Ruitenberg3, P. G. McMenamin1.
1
Monash Biomedicine Discovery Institute and
Department of Anatomy and Developmental
Biology, Monash University, Clayton, VIC,
Australia; 2Department of Optometry and Vision
Sciences, University of Melbourne, Parkville,
VIC, Australia; 3School of Biomedical Sciences,
University of Queensland, St Lucia, QLD, Australia
3300 — D0042 A monoclonal antibody
targeting the HSV-1/2 glycoprotein B inhibits
the development herpes simplex virus type 1
retinitis in mice. Dirk Bauer1, M. Alt2, M. Dirks2,
M. Kasper1, A. Buch3, U. Dittmer2, A. Goergens4,
B. Sodeik3, A. Heiligenhaus1, R. Michael2,
A. Krawczyk2. 1Ophtha-Lab, Department of
Ophthalmology at St. Franziskus Hospital, Munster,
Germany; 2Institute of Virology, University Hospital
Essen, Essen, Germany; 3Department of Virology,
Hannover Medical School, Hannover, Germany;
4
Department for Transfusion Medicine, University
Hospital Essen, Essen, Germany *CR
3301 — D0043 Ocular Manifestations In
Dengue Fever. Anne-Laure Remond, N. Butel,
C. Fardeau, M. Errera, P. LeHoang, B. Bodaghi.
Department of Ophthalmology, Pitie-Salpetriere,
Paris, France
3302 — D0044 Th17-associated cytokines in
aqueous humor of acute primary angle-closure
eyes. Shida Chen, Y. liu, X. li, X. Zhang. zhongshan
ophthalmic center, Guangzhou, China
3303 — D0045 The relationship between
quantitative pupillometry and estimated
ganglion cell counts in patients with glaucoma.
Dolly S. Chang, M. V. Boland, K. Arora, D. S.
Friedman. Ophthalmology, Wilmer Eye Institute,
Johns Hopkins University, Baltimore, MD
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
229
Tuesday Posters
8:30 am – 10:15 am
3286a — C0086a Novel biomarkers of diabetic
retinopathy based on dynamic fluorescein
enhanced fluorescent imaging. Jennifer J. KangMieler, E. Dosmar, W. Liu, S. Hu, K. M. Tichauer.
Biomedical Engineering, Illinois Institute of
Technology, Chicago, IL
3290 — D0032 Inhibition of Fibrin
and Inflammation with Enoxaparin and
Triamcinolone in a Juvenile Rabbit Model of
Lensectomy. Jonathon Young1, D. Conklyn2, J.
Bogaard3, H. Whiteley4, I. S. Kassem2, 1. 1Cell
Biology, Neurobiology & Anatomy, Medical
College of Wisconsin, Milwaukee, WI; 2Department
of Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 3Ophthalmology, University
of Illinois at Chicago, Chicago, IL; 4Veterinary
Medicine, University of Illinois at UrbanaChampaign, Champaign, IL *CR
Tuesday Posters
8:30 am – 10:15 am
3304 – 3324 – Tuesday – Posters
3304 — D0046 Aqueous humour cytokines
in Fuchs uveitis syndrome patients with or
without secondary glaucoma. Carsten Heinz1, 2,
M. Kasper1, O. Tektas3, D. Bauer1, K. Walscheid1,
J. Koch1, P. Muether4, A. Heiligenhaus1, 2.
1
Ophthalmology, St. Franziskus Hospital,
Muenster, Germany; 2Ophthalmology, University
Duisburg-Essen, Essen, Germany; 3Anatomy,
University Nuremberg-Erlangen, Erlangen,
Germany;4Ophthalmology, University Koeln,
Koeln, Germany
3310 — D0052 Variability in full-field
electoretinogram measurements in patients with
birdshot chorioretinopathy. Jared E. Knickelbein,
M. Wei, B. G. Jeffrey, R. B. Nussenblatt, H. Sen.
National Eye Institute, Bethesda, MD
3305 — D0047 Validation study for an imagebased standardized grading system for scleritis.
Maggie M. Wei, J. E. Knickelbein, K. R. Armbrust,
D. Cunningham, S. Vitale, R. B. Nussenblatt, H.
Sen. Department of Ophthalmology, National
Institute of Health, Bethesda, MD
3312 — D0054 Visual Acuity and Inflammation
Outcomes in Intermediate Uveitis. Elliot Crane1,
M. Shum1, J. S. Kim1, E. Kim1, A. B. Crane1, D. S.
Chu1, 2. 1Rutgers New Jersey Medical School, Pine
Brook, NJ; 2Metropolitan Eye Research and Surgery
Institute, Palisades Park, NJ
3306 — D0048 Establishment and
characterization of hIRBP-induced experimental
autoimmune uveoretinitis in mice. Jian Li1, J.
Ren2, W. Yip1, X. Zhang1, S. Chan2, W. Chu1, C.
C. Pang1. 1Department of Ophthalmology and
Visual Sciences, The Chinese University of Hong
Kong, Hong Kong, China; 2School of Biomedical
Sciences, The Chinese University of Hong Kong,
Hong Kong, China
3313 — D0055 TIGIT+ Tregs May Be
Associated with Clinical Remission of NonInfectious Uveitis. Rose Gilbert1, 2, X. Zhang1, R.
Sampson1, O. Tomkins-Netzer2, 1, G. Galatowicz1,
V. L. Calder1, S. Lightman2, 1. 1UCL Institute
of Ophthalmology, London, United Kingdom;
2
Moorfields Eye Hospital, London, United Kingdom
3307 — D0049 Differentiating Endophthalmitis
from Uveitis and Vitreoretinal Lymphoma by
Aqueous and Vitreous IL-6 and IL-10. David
Kuo, M. M. Wei, K. R. Armbrust, I. Yeung, C. Chan,
R. B. Nussenblatt, H. Sen. National Eye Institute,
National Institutes of Health, Bethesda, MD
3308 — D0050 Adalimumab in patients with
active and inactive, non-infectious uveitis:
VISUAL I and VISUAL II trials. Antoine P.
Brezin1, A. D. Dick2, 3, G. J. Jaffe4, S. Ohno5, K.
Namba5, H. Goto6, N. Inomata7, A. P. Song8, M.
Kron9, A. Camez9, Q. Nguyen10. 1INRA, CNRS,
University of Burgundy, Hopital Cochin-Univ
Paris Descartes, Paris, France; 2University of
Bristol, Bristol Eye Hospital, Bristol, United
Kingdom;3National Institute for Health Research
(NIHR) Biomedical Research Centre at
Moorfields Eye Hospital and University College
London, Institute of Ophthalmology, London,
United Kingdom; 4Duke University, Durham,
NC;5Hokkaido University Graduate School
of Medicine, Sapporo, Japan; 6Tokyo Medical
University, Tokyo, Japan; 7AbbVie GK Japan,
Tokyo, Japan; 8AbbVie Inc., North Chicago,
IL; 9AbbVie Deutschland GmbH & Co KG,
Ludwigshafen, Germany; 10Truhlsen Eye Institute,
University of Nebraska Medical Center, Omaha, NE
*CR, f
3309 — D0051 The effect of topical
difluprednate on vascular leakage in noninfectious uveitis. Daniel Feiler, C. Y. Lowder, K.
Baynes, S. K. Srivastava. Ophthalmology, Cleveland
Clinic Cole Eye Institute, Cleveland, OH *CR
3311 — D0053 Literature Review:
Comorbidities and Complications with
Intermediate Uveitis. Eliott Kim, E. Crane, J.
S. Kim, M. Shum, D. S. Chu. Rutgers University,
Newark, NJ
3314 — D0056 The development of ocular
complications in subjects diagnosed with
intermediate uveitis. Jason S. Kim, E. Kim, E.
Crane, M. Shum, D. S. Chu. Rutgers University,
New York, NY
3315 — D0057 Determination of CD4/
CD8 ratio in undiluted vitreous samples
provides useful information for the diagnosis
of ocular sarcoidosis. Joachim Van Calster, R.
Van Ginderdeuren. University Hospitals Leuven,
Leuven, Belgium
3316 — D0058 Choroidal thickness is a marker
for successful tapering of therapy in VKH
disease. Enzo Castiglione, R. Anguita, T. Barrueto,
C. Lopez, F. Rojas, R. Vidal. Departamento de
Oftalmologia, Universidad de Chile, Santiago, Chile
3317 — D0059 Tubulointerstitial Nephritis
and Uveitis Syndrome: Characterization of
Clinical Features. Anjum F. Koreishi, R. Desai,
A. Birnbaum, D. Pyatetsky, D. A. Goldstein.
Ophthalmology, Northwestern University,
Chicago, IL
3318 — D0060 Increased Frequency of Herpes
Simplex Virus-Specific Effector Memory
CD26+CD8+ T Cells in HSV-Seropositive
Ocular Herpes Asymptomatic Patients. Anthony
B. Nesburn, R. Srivastava, A. Khan, S. Wechsler,
L. BenMohamed. Gavin Herbert Eye Institute,
University of California Irvine, Irvine, CA
3319 — D0061 Exploring associations
between anatomical and functional parameters
in Birdshot chorioretinopathy using optical
coherence tomography and electroretinography.
William R. Tucker1, 2, A. E. Hobby2, 1, I. T. Hossain2,
C. J. Hammond2, M. R. Stanford2, O. A. Mahroo2, 1.
1
Medical Retina, Moorfields Eye Hospital, London,
United Kingdom; 2Ophthalmology, King’s College
London, St Thomas’ Hospital Campus, London,
United Kingdom
3320 — D0062 Computational Methods for
Analyzing Patient Data. Alexander B. Crane,
E. Crane, M. Shum, J. S. Kim, E. Kim, D. S. Chu.
Ophthalmology, Rutgers, Pine Brook, NJ
Exhibit/Poster Hall D0124-D0173
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Retina
324 AMD and anti-VEGF Therapy 2
Moderators: Milam A. Brantley and
Jay M. Stewart
3321 — D0124 AAV2 Mediated Expression
of Intraceptor Flt23k Shows No Endoplasmic
Reticulum Stress Response. Austin Bohner, X.
Zhang, H. Uehara, B. Archer, B. Ambati. John
Moran Eye Center, University of Utah School of
Medicine, Salt Lake City, UT
3322 — D0125 Dose-Efficacy and Safety of
Targeted Intraceptor Flt23k Nanoparticle in
Mice. Xiaohui Zhang, A. Bohner, S. Bondalapati,
S. K. Kumar Muddana, H. Uehara, B. Archer, B.
Ambati. Moran Eye Center, University of Utah,
Salt Lake City, UT
3323 — D0126 Systemic VEGF Inhibition
does not modulate ocular inflammatory cell
infiltrate in the murine laser-induced choroidal
neovascularization (CNV) Model. Adrian WillOrrego, S. Liao, Y. Qiu, E. Fassbender, S. Shen, N.
Kotagiri, B. D. Jaffee, S. H. Poor. Ophthalmology,
Novartis Institutes for Biomedical Research,
Cambridge, MA *CR
3324 — D0127 Retinal Toxicity of Intravitreal
Injection of Ziv-Aflibercept in albino rabbits.
Dan M. Ramon5, Y. Shahar2, 1, A. Massarweh3, I.
Mann3, I. Perlman3, 4, A. Loewenstein1, 2. 1Sackler
Faculty of Medicine, Tel-Aviv University, Tel-Aviv,
Israel; 2Department of Ophthalmology, Tel-Aviv
Medical Center, Tel-Aviv, Israel; 3Department
of Physiology and Biophysics, Technion-Israel
Institute of Technology, Ruth & Bruce Rappaport
Faculty of Medicine, Haifa, Israel; 4Rappaport
Institute, Haifa, Israel; 5Ruth & Bruce Rappaport
Faculty of Medicine, Technion-Israel Institute of
Technology, Haifa, Israel
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
230
Tuesday – Posters – 3325 – 3343
3325 — D0128 Ranibizumab and Bevacizumab
treatment after retinal ischemia-reperfusion
injury in a rodent model. Marina Renner, S.
Lohmann, D. Schulte, G. Stute, H. Dick, S. Joachim.
Experimental Eye Research Institute, University
Eye Hospital, Bochum, Germany
3326 — D0129 Clearance of Aflibercept
Following Intravitreal Injection in a Rat Model.
Ruti Sella1, 2, O. Gal-Or1, A. Dotan1, M. Dachbash3,
Y. Nisgav3, D. Weinberger1, 2, R. Ehrlich1, 2, T.
Livnat2, 3.1Department of Ophthalmology, Rabin
Medical Center, Petach-Tikva, Israel; 2Sackler
School of Medicine, Tel-Aviv University, Tel Aviv,
Israel; 3Laboratory of Eye Research, Felsentstein
Medical Research Center, Rabin Medical Center,
Petach-Tikva, Israel
3328 — D0131 ROS-responsive nanoparticles
to extend the lifetime of anti-angiogenic
drugs. Viet Anh Nguyen Huu1, J. Zhu2, J. Luo2, S.
Patel2, G. Collet3, C. de Gracia Lux3, K. Zhang2,
A. Almutairi3.1Nanoengineering & School of
Pharmacy, University of California, San Diego,
La Jolla, CA; 2School of Medicine, University of
California, San Diego, La Jolla, CA; 3School of
Pharmacy, University of California, San Diego,
La Jolla, CA
3329 — D0132 Experimental model to
characterize bubble formation in intravitreal
injections. Jackson Abou Chehade, E. Elborgy, S.
Alniemi, B. Nicholson, R. Iezzi. Ophthalmology,
Mayo Clinic, Rochester, MN
3330 — D0133 Optimal Buffer for Storage of
Ranibizumab at Low Concentrations. Hui Yee
Chua1, R. V. Agrawal5, T. T. Wong4, P. Preiser3,
S. Venkatraman2. 1Interdisciplinary Graduate
School, Nanyang Technological University,
Singapore, Singapore; 2Materials Science and
Engineering, Nanyang Technological University,
Singapore, Singapore; 3Biological Sciences,
Nanyang Technological University, Singapore,
Singapore;4Singapore Eye Research Institute,
Ocular Drug Delivery Group Singapore National
Eye Centre, Singapore, Singapore; 5National
Healthcare Group Eye Institute, Tan Tock Seng
Hospital, Singapore, Singapore
3332 — D0135 Factors associated with
retreatment after photodynamic therapy
combined with intravitreal ranibizumab for
polypoidal choroidal vasculopathy. Wataru
Kikushima, Y. Sakurada, A. Sugiyama, N. Tanabe, S.
Yoneyama, H. Iijima. Ophthalmology, University of
Yamanashi, Chuo, Japan
3333 — D0136 Real Life Setting Treatment
By Anti-Vascular Endothelial Growth Factor
For Wet Age-Related Macular Degeneration:
Inactivation Of Lesion And Long Term
Outcomes. Mohamed Maher Haouas2, 1, G.
Thuret2, 3, P. GAIN2, M. Paques1, J. Sahel1, J.
Girmens1. 1DHU SightRestore, Quinze-Vingts
National Hospital, Paris, France;2Ophtalmology,
Hospital North, Saint-Etienne, France; 3France
University Institute, Paris, France *CR
3334 — D0137 Real-life outcomes of switching
AntiVEGF treatment from ranibizumab to
aflibercept for neovascular agerelated macular
degeneration (nAMD): UK multicentre study.
Faruque D. Ghanchi1, N. Patel2, J. S. Talks3, A. J.
Lotery4, S. Sivaprasad7, C. Bailey5, R. Johnston6,
M. McKibbin8. 1Ophthalmology, Bradford teaching
Hospitals, Bradford, United Kingdom; 2East Kent
University Hospitals, Canterbury, United Kingdom;
3
Newcastle Upon Tyne Hospitals Foundation NHS
Trus, Newcastle upon Tyne, United Kingdom;
4
Faculty of Medicine, University of Southampton,
Southampton, United Kingdom; 5Bristol Eye
Hospital, Bristol, United Kingdom; 6Gloucestershire
Hospitals NHS Foundation Trust, Gloucester,
United Kingdom; 7Kings College Hospital, London,
United Kingdom; 8St James University Hospital,
Leeds, United Kingdom *CR
3335 — D0138 Real-world treatment patterns
in injection cost and frequency for ranibizumab
versus aflibercept in patients with wet agerelated macular degeneration: A 2-year US
claims analysis. Szilard Kiss1, Y. Rajput2, C.
Quezada Ruiz2, K. Wilson3, A. Huang3, D. M.
Smith3, H. Varker3, S. S. Johnston3. 1Physics &
Astronomy/Sch of Optometry, Weill Cornell
Medical College, New York, NY; 2Genentech, Inc.,
South San Francisco, CA; 3Truven Health Analytics,
Bethesda, MD *CR
3336 — D0139 Factors associated with poor
response to aflibercept after switching from
ranibizumab or bevacizumab in neovascular
age-related macular degeneration (AMD).
Sarah Cheng, T. Leng. Ophthalmology, Stanford
University, Palo Alto, CA *CR
3337 — D0140 Safety and complications of
Intravitreal injections performed over 8 years at
a tertiary eye centre in Singapore. Yanping Xu, C.
S. Tan. Ophthalmology, National Healthcare Group
Eye Institute, Singapore, Singapore
3338 — D0141 Patient-level Meta-analysis of
the Safety of Bevacizumab vs Ranibizumab in
International Randomized Clinical Trials for the
Treatment of Neovascular Age-Related Macular
Degeneration. James A. Shaffer. Ophthalmology,
University of Pennsylvania, Philadelphia, PA f
3339 — D0142 Evaluation of cytotoxicity
of Pazopanib on proliferation of vascular
endothelial growth factor enriched choroidal
vascular endothelial cells. K. V. Chalam,
B. Mynampati Arunadithya, K. Sambhav.
Ophthalmology, University of Florida,
Jacksonville, FL
3340 — D0143 A real-world evaluation of
frequency of ranibizumab and aflibercept
deliveries for treatment-naïve patients with
neovascular age-related macular degeneration:
12-month results from the French LYVE survey.
Oudy Semoun1, R. Blanco-Garavito1, S. Y. Cohen2,
L. Finzi3, C. Maurin3, E. H. Souied1. 1Ophtalmology,
Centre Hospitalier Intercommunal de Créteil,
Créteil, France; 2Centre Imagerie et Laser, Paris,
France; 3Retine, Novartis Pharma SAS, RueilMalmaison, France *CR
3341 — D0144 Angiogenesis Agents Levels
After Bevacizumab Intravitreal Injection in
Patients with Neovascular Age-related Macular
Degeneration. Thiago Cabral1, 2, L. H. Lima1, J.
Polido1, E. P. Correia3, P. D. Serracarbassa3, C. V.
Regatieri1, B. Rubens1. 1Ophthalmology, UNIFESP,
Vitoria/ES, Brazil; 2Ophthalmology, UFES, Vitória,
Brazil; 3Ophthalmology, HSPE/IAMSPE,
Sao Paulo, Brazil
3342 — D0145 Real-world one year outcomes
of a switch to aflibercept from ranibizumab in
neovascular age related macular degeneration.
Maria C. Citu, R. R. Crosby-Nwaobi, M.
Eleftheriadou, C. Vazquez-Alfageme, L. Nicholson,
S. Sivaprasad, P. Hykin, R. D. Hamilton. NIHR
Biomedical Research Centre at Moorfields Eye
Hospital and UCL Institute of Ophthalmology,
London, United Kingdom *CR
3343 — D0146 Real World U.S. Outcomes
of Anti-Vascular Endothelial Growth Factor
(VEGF)Therapy in Neovascular AMD (NAMD):
Risk of Vision Loss is Greatest in Patients with
Better Baseline Visual Acuity. Forbes Huang1, K.
Westby1, D. F. Williams2, T. A. Ciulla1, S. Zaveri1,
S. Patel1. 1Ophthotech, Princeton, NJ; 2Vestrum
Health, Naperville, IL *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
231
Tuesday Posters
8:30 am – 10:15 am
3327 — D0130 What is the biologically
relevant KD for VEGF binding to ranibizumab
in the eye? A comparison of in-vivo and in-vitro
estimates. Norman Mazer1, D. Schwab1, L. HuttonSmith2, H. M. Byrne2, E. A. Gaffney2, P. Maini2,
G. Hartmann3, J. Moelleken4, C. Gassner4, J. T.
Regula4. 1Clinical Pharmacology, Roche Innovation
Center Basel, Basel, Switzerland; 2Wolfson
Centre of Mathematical Biology, University of
Oxford, Oxford, United Kingdom; 3Neuroscience
Ophthalmology and Rare Diseases, Roche
Innovation Center Basel, Basel, Switzerland; 4Large
Molecule Research, Roche Innovation Center
Penzberg, Penzberg, Germany *CR
3331 — D0134 No excuses. Bevacizumab
should be first choice in AMD. Freekje Van
Asten1, C. Michels2, C. C. Hoyng1, G. van der
Wilt2, B. Klevering1, M. M. Rovers2, J. P. Grutters2.
1
Ophthalmology, Radboud umc, Nijmegen,
Netherlands; 2Health Evidence, Radboud umc,
Nijmegen, Netherlands
3344 – 3364 – Tuesday – Posters
3344 — D0147 Variation in Ophthalmologist
Use of Anti-VEGF Therapy Among Medicare
Beneficiaries. Rachel Thakore1, P. B. Greenberg6, 4,
D. French2, 3, J. J. Behrens5. 1Warren Alpert Medical
School of Brown University, Providence, RI;
2
Department of Ophthalmology and the Center for
Healthcare Studies, Feinberg School of Medicine,
Northwestern University, Chicago, IL; 3Veterans
Affairs Health Services Research and Development
Service, Chicago, IL; 4Ophthalmology, Providence
VA Medical Center, Providence, RI; 5Center
for Healthcare Studies, Feinberg School of
Medicine, Northwestern University, Chicago, IL;
6
Ophthalmology, Warren Alpert Medical School of
Brown University, Providence, RI
3351 — D0154 Association between prior
response to ranibizumab treatment and disease
quiescence: Implications for AMD dosing.
Rahul N. Khurana1, L. K. Chang1, H. Shapiro2, A.
Ghanekar2, S. Gune2.1Retina, Northern California
Retina Vitreous Associates, Mountain View, CA,
CA; 2Genentech, Inc., South San Francisco, CA
*CR, f
3345 — D0148 Patient satisfaction with nurse
delivered intravitreal injections. adam mapani,
Y. Khan. Medical Retina Service, Moorfields Eye
Hospital, London, United Kingdom *CR
3353 — D0156 Time to recurrence in
neovascular age-related macular degeneration
after ranibizumab treatment: baseline
characteristics of treatment-naive patients
enrolled in the ORACLE study.François Devin9,
E. Fourmaux1, G. quentel2, J. Uzzan3, M. Quaranta
El-Maftouhi4, C. Français-Maury5, W. Roquet6, L.
Castelnovo10, S. Razavi7, L. Finzi8. 1Ophtalmology,
Palais Galien, Bordeaux, France;2Centre Imagerie
et Laser, Paris, France; 3Ophtalmology, Clinique
Mathilde, Rouen, France; 4Ophtalmology, Centre
Rabelais, Lyon, France; 5Ophtalmology, Centre
de l’Odéon, Paris, France; 6Ophtalmology, Centre
Blatin, Clermont-Ferrand, France; 7Ophtalmology,
Clinique Saint-Gatien, Tours, France; 8Retine,
Novartis Pharma SAS, Rueil-Malmaison, France;
9
Ophtalmology, Centre Monticelli Paradis,
Marseille, France; 10Ophtalmology, Clinique Maison
Rouge, Strasbourg, France *CR
Tuesday Posters
8:30 am – 10:15 am
3346 — D0149 Outcomes of an intravitreal
injection clinic. Elizabeth Atchison1, S. J. Bakri1, A.
F. Omar2. 1Ophthalmology, Mayo Clinic, Rochester,
MN; 2Ophthalmology, UT Southwestern Medical
Center, Dallas, TX *CR
3347 — D0150 Evaluation of the efficiency
of intravitreal Aflibercept in patients affected
with Occult Choroidal Neovascularisation
(OCNV), Polypoidal Choroidal Vasculopathy
(IPVC) and Retinal Angiomatous Proliferation
(RAP) previously treated with intravitreal
Ranibizumab. Simona Altimari, R. Salvati, L.
Zompatori. San Giovanni Evangelista Hospital,
Tivoli, Italy
3348 — D0151 Efficacy of aflibercept in
wet age-related macular degeneration nonresponsive to ranibizumab. Darren Shu Jeng Ting,
J. Suleman, P. S. Severn, S. Pushpoth. The James
Cook University Hospital, Middlesbrough,
United Kingdom
3349 — D0152 Prediction of low and high antiVEGF treatment requirements during the PRN
phase from early OCT images in neovascular
age-related macular degeneration. Hrvoje
Bogunovic1, S. M. Waldstein1, A. Sadeghipour1,
T. Schlegl1, B. Gerendas1, A. Osborne2, U.
Schmidt-Erfurth1. 1Christian Doppler Laboratory
for Ophthalmic Image Analysis, Department of
Ophthalmology, Vienna Reading Center, Vienna,
Austria; 2Genentech, Inc, South San Francisco, CA
*CR, f
3350 — D0153 Consideration of the benefit of
additional intravitreal anti-vascular endothelial
growth factor injection in polypoidal choroidal
vasculopathy patients with chronic subfoveal
subretinal fluid.Jeehyun Kim, Y. Kim, K. Kim.
Keimyung University Dongsan Medical Center,
Daegu, Korea (the Republic of)
3352 — D0155 Retinal angiomatous
Proliferations- does the treatment outcome
depend on the stage? A retrospective
follow-up. Johanna Maass. Ophthalmology,
Universitätsklinikum Carl Gustav Carus,
Dresden, Germany
3354 — D0157 An overview of medical
practices in neovascular age-related macular
degeneration: evaluating the changes in
France between 2013 and 2016. Nathalie San
Nicolas1, V. Gualino2, J. Zerbib3, T. Grenet4, M.
Streho5, J. Halfon6, P. Cornut7, A. Bourhis8, C.
Maurin1, H. Masse9. 1Novartis Pharma SAS, RueilMalmaison, France; 2Ophtalmology, Clinique
Honoré Cave, Montauban, France; 3Ophtalmology,
Private practice, Nice, France; 4Centre Imagerie
et Laser, Paris, France; 5Centre Exploration de
la Vision, Rueil-Malmaison, France; 6Cabinet
D’ophtalmologie des Halles de Tours, Tours,
France; 7Pôle Vision, Clinique Du Val d’Ouest,
Lyon, France; 8Ophtalmology, Polyclinique
de L’Atlantique, Saint-Herblain, France;
9
Ophtalmology, CHU Nantes, Nantes, France *CR
3355 — D0158 Efficacy of Aflibercept in
Treatment-naïve Neovascular Age-related
Macular Degeneration: Two-Year Real World
Outcomes. Maria Eleftheriadou, C. VazquezAlfageme, M. C. Citu, R. R. Crosby-Nwaobi, S.
Sivaprasad, P. Hykin, R. D. Hamilton, P. J. Patel.
NIHR Biomedical Research Centre at Moorfields
Eye Hospital and UCL Institute of Ophthalmology,
London, United Kingdom *CR
3356 — D0159 Recurrences in neovascular
age related macular degeneration: are they
predictable in a clinical setting? Stefano Erba, G.
Delledonne, C. D. Bianchi, M. Cozzi, A. Babbi, M.
V. Cigada, F. Bottoni, G. Staurenghi. Biomedical
and clinical sciences “Luigi Sacco”, Sacco Hospital
Eye Clinic, University of Milan, Milano, Italy *CR
3357 — D0160 Fc receptor inhibition reduces
susceptibility to oxidative stress in human
RPE cells treated with bevacizumab, but not
aflibercept. Mahdy Ranjbar, M. Brinkmann,
D. Zapf, Y. Miura, M. Rudolf, S. Grisanti.
Ophthalmology, University of Lübeck,
Lübeck, Germany
3358 — D0161 Comparative Effects of
Bevacizumab and Aflibercept on VEGF and IGF
Signaling in Human Retinal Endothelial Cells
Exposed to Hyperoxia and Intermittent Hypoxia.
Amirfarbod Yazdanyar, C. Cai, A. Taimur, E. shrier,
D. R. Lazzaro, G. Valencia, J. Aranda, K. Beharry.
Ophthalmology, SUNY Downstate Medical Center,
Brooklyn, NY
3359 — D0162 No improvement in visual
outcome over time in two cohorts from the same
county in patients treated for wet AMD. Marion
Schroeder, L. Rung, M. K. Lovestam Adrian. Lund
University, Malmö, Sweden
3360 — D0163 Impact of practice modifications
on infectious endophthalmitis rates following
intravitreal injection of anti-vascular endothelial
growth factor. Maya Maloney, A. Barkmeier, S. J.
Bakri, R. Iezzi, J. Pulido, W. Smith, J. Erie. Mayo
Clinic, Rochester, MN *CR
3361 — D0164 Suppression of laser-induced
choroidal neovascularization by intravitreal
injection of collagen type Ii, alpha 1 peptide in
mouse model. Byul-Nim Ahn, D. Hur, J. Yang, S.
Kim. Inje Univ. Busan Paik hospital, Busan, Korea
(the Republic of)
3362 — D0165 Adherence to treatment
determines 5-year outcome in neovascular AMD
in a real-life setting. Robert G. Wilke, H. G. Sachs.
KH Dresden - Friedrichstadt, Dresden, Germany
*CR
3363 — D0166 Ranibizumab, Bevacizumab,
and Aflibercept accumulation and their effect
on cell migration and permeability on human
ARPE-19 cells. Patricia Fernandez1, 2, M.
Saenz de Viteri1, S. Recalde1, 2, M. Hernandez1, 2,
J. Bezunartea-Bezunartea1, 2, E. Alonso1, M.
Moreno-Orduna1, N. Aguado1, I. Belza1, A.
Garcia-Layana1, 2. 1Experimental Ophthalmology
Laboratory, Clinica Universidad de Navarra,
Pamplona, Spain; 2IdiSNA, Navarra Institute for
Heatl Research, Pamplona, Spain *CR
3364 — D0167 Peripapillary Choroidal
Thickness Change of Polypoidal Choroidal
Vasculopathy after Anti-Vascular Endothelial
Growth Factor Treatment. Kyou Ho Lee, J.
Lee. Ophthalmology, Severance hospital, Yonsei
University, Seoul, Korea (the Republic of)
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
232
Tuesday – Posters – 3365 – 3382
3365 — D0168 Clinical outcomes of treatment
switching in neovascular age-related macular
degeneration (nAMD): a retrospective cohort
study in the United States (US) using electronic
medical records. Frances Milnes1, R. Griner2,
A. Ferreira1, A. Skelly3, P. U. Dugel4. 1Novartis
Pharma AG, Basel, Switzerland; 2IMS Health Inc.,
Burlington, MA; 3Novartis Ireland Limited, Dublin,
Ireland; 4Retinal Consultants of Arizona,
Phoenix, AZ *CR
3366 — D0169 Systemic Pharmacodynamic
Effects of Anti-Vascular Endothelial Growth
Factor (VEGF) Agents in Patients With Wet AgeRelated Macular Degeneration. Peter K. Kaiser1,
L. Kodjikian2, J. Korobelnik3, O. Zeitz4, R. Vitti5,
C. Metzig4, C. Ahlers4, T. dicioccio5, J. Hoechel4.
1
Ophthalmology, Cole Eye Institute, Cleveland,
OH; 2Hopital de la Croix-rousse, Lyon, France;
3
Université de Bordeaux, Bordeaux, France;4Bayer
Pharma AG, Berlin, Germany; 5Regeneron
Pharmaceutical Inc., Tarrytown, NY *CR, f
3368 — D0171 Ranibizumab treatment
according to the subtypes of choroidal
neovascularisation due to neovascular Agerelated Macular Degeneration in a real-life.
3 years interim analysis of a French national
observational and multicentric retrospective
study: COLOR. David Sayag1, F. Coscas2,
G. Mimoun3, C. Favard2, C. Francais-Maury2,
V. Krivosic2, V. Pierre-Kahn1. 1Rétina, Centre
Exploration Vision, PARIS, France; 2Centre
Ophtalmologique de l’Odéon, Paris, France; 3Centre
Ophtalmologique d’Imagerie de l’Ecole Militaire,
Paris, France
3369 — D0172 Anatomical and functional
effects of subretinal rAAV.sVEGFR-1 gene
therapy on retinal-choroidal structures in
nonhuman primates. Sharmila Vijay1, K. W.
Woodburn1, P. Sharma1, T. W. Chalberg1, V.
Woodley2, J. Attwood2, M. S. Lawrence2, M. Gasmi1.
1
Avalanche Biotechnologies, Menlo Park, CA;
2
RxGen Inc, Hamden, CT *CR
3370 — D0173 6 weeks PRN intravitreal
treatments results for macular diseases. One
year clinical practice data. Marcos J. Rubio Caso,
R. Morwani Morwani, C. Veiga Sanchez-Tinajero,
L. Arias Barquet, J. Caminal Mitjana. Hospital
Universitari de Bellvitge, Sant Boi de Llobregat Barcelona, Spain *CR
Tuesday, May 03, 2016 8:30 AM-10:15 AM
Multidisciplinary Ophthalmic Imaging Group /
Lens / Low Vision
325 Clinical Imaging - Miscellaneous
Moderators: Linda M. Zangwill and
Masahiro Miura
3371 — D0308 Window to the central nervous
system-Retinal examination for early diagnosis
of Alzheimer’s disease. Lily Yu-Li Chang1, 2, M.
L. Acosta1, 2, J. Black1, 2. 1Optometry, University of
Auckland, Auckland, New Zealand; 2New Zealand
National Eye Centre, The University of Auckland,
Auckland, New Zealand
3372 — D0309 Retinal Biomarkers of
Alzheimer’s Disease. Heather Whitson1, 2, S.
Farsiu3, S. S. Stinnett3, L. Kwark3, G. Potter4, J.
Burke5, S. W. Cousins3, E. M. Lad3. 1Medicine, Duke
University, Durham, NC; 2GRECC, Durham VA
Medical Center, Durham, NC; 3Ophthalmology,
Duke University, Durham, NC; 4Psychiatry and
Behavioral Sciences, Duke University, Durham,
NC; 5Neurology, Duke University, Durham, NC
3373 — D0310 Retinal imaging in early and
late Alzheimer’s disease. Lajos Csincsik1, T.
Shakespeare2, N. Quinn4, R. E. Hogg4, S. Crutch2,
R. Craigh5, T. Peto3, 1, I. Lengyel1. 1ORBIT, UCL
Institute of Ophthalmology, London, United
Kingdom; 2Dementia Research Centre, UCL
Institute of Neurology, London, United Kingdom;
3
NIHR Biomedical Research Centre, Moorfields
Eye Hospital NHS Foundation Trust, London,
United Kingdom; 4Queen’s University - Centre for
Experimental Medicine, Belfast, United Kingdom;
5
University of Edinburgh, Edinburgh, United
Kingdom
3374 — D0311 A technique for measurement
of ganglion cell and retinal nerve fiber layer
thickness change with age in an Alzheimer’s
disease (AD) mouse model using human
spectral domain optical coherence tomography
(OCT). Keegan Harkins, M. A. Sadiq, V. Gulati,
S. J. Havens, S. Fan, T. Rudebush, D. A. Ghate.
Ophthalmology, Truhlsen Eye Institute - UNMC,
Omaha, NE
3375 — D0312 Assessment of corneal
properties using Optical Coherence Tomography
Speckle: A pilot study. Danilo A. Jesus, D.
Iskander. Wroclaw University of Technology,
Wroclaw, Poland
3376 — D0313 Microscope-integrated
Intraoperative Optical Coherence Tomography
Enables Real-Time Monitoring Of Corneal
Structural Alterations During Collagen
Crosslinking. Sebastian E. Siebelmann1, 2, J.
Horstmann1, 2, M. M. Hermann1, B. Bachmann1,
C. Cursiefen1, P. Steven1, 2. 1Department of
Ophthalmology, University of Cologne, Cologne,
Germany; 2Cluster of Excellence: Cellular Stress
Responses in Aging-associated Diseases (CECAD),
University Hospital of Cologne, Cologne, Germany
*CR
3377 — D0314 A New Method for Measuring
Corneal Epithelial Thickness. Esther Young, H.
Bagherinia, P. Sha, M. K. Durbin. R&D, Carl Zeiss
Meditec, Inc., Dublin, CA *CR
3378 — D0315 Non-invasive Assessments of the
Sclera and Cornea after Collagen Crosslinking
and Glycosaminoglycan Depletion using Multimodal MRI. Kevin C. Chan1, 2, L. C. Ho1, 4, I. A.
Sigal2, 3, N. Jan2, 3, X. Yang1, 2, Y. van der Merwe1, 3,
G. Wollstein2, 3, J. S. Schuman2, 3. 1NeuroImaging
Laboratory, University of Pittsburgh, Pittsburgh,
PA; 2UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 3Department of
Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, PA;
4
Department of Electrical and Electronic
Engineering, University of Hong Kong, Hong
Kong, China *CR
3379 — D0316 Corneal subbasal nerve plexus
Decreases in Limbal stem cell deficiency patients.
Pichaya Chuephanich, C. Supiyaphun, C. Aravena
Perez, T. Bozkurt, F. Yu, S. X. Deng. Ophthalmology,
Jules Stein Eye Institute, Los Angeles, CA
3380 — D0317 Pediatric Anterior Segment
Ultrasound Biomicroscopy Image Analysis: Intra
and Inter-observer Agreement. Haoxing Chen1, A.
Qureshi1, O. Saeedi2, 3, M. A. Kaleem2, 3, J. Margo2, 3,
S. Kalarn3, J. D. Leath2, 3. 1University of Maryland
School of Medicine, Baltimore, MD; 2Department
of Ophthalmology, University of Maryland Eye
Associates, Baltimore, MD; 3Department of
Ophthalmology and Visual Sciences, University of
Maryland School of Medicine, Baltimore, MD
3381 — D0318 Assessment and Comparison
of Automated Anterior Chamber Metrics
between Casia Swept-Source OCT vs Pentacam
Scheimpflug Imaging. Kenneth Marion1, 2, A.
Dastiridou1, 2, B. Francis1, 2, V. Chopra1, 2. 1Doheny
Eye Institute, Los Angeles, CA; 2University of
California Los Angeles, Los Angeles, CA *CR
3382 — D0319 Anterior chamber angle
imaging with Automatic Gonio-Photography.
Carlo Alberto Cutolo1, A. Bagnis1, R. Scotto1, C.
Bonzano1, P. Frascio1, M. Pascolini2, C. Tanassi2,
C. E. Traverso1.1University Eye Clinic, University
of Genoa, Genoa, Italy; 2NIDEK Technologies Srl,
Padua, Italy *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
233
Tuesday Posters
8:30 am – 10:15 am
3367 — D0170 A systematic review to assess
the “Treat-and-Extend” dosing regimen
compared to monthly and as-needed dosing for
neovascular age-related macular degeneration
using ranibizumab.Sohaib R. Rufai1, 2, H.
Almuhtaseb1, H. Lee1, 2, R. Paul2, B. Stuart2, T.
Kendrick2, A. J. Lotery1, 2. 1Southampton Eye Unit,
University Hospital Southampton, Southampton,
United Kingdom; 2Faculty of Medicine, University
of Southampton, Southampton, United Kingdom
*CR
Exhibit/Poster Hall D0308-D0351
3383 – 3405 – Tuesday – Posters
3383 — D0320 Imaging of aqueous outflow
system structures using ultrahigh-resolution
optical coherence tomography. Rene M.
Werkmeister1, S. Sapeta1, V. Aranha dos Santos1, G.
Garhofer2, L. Schmetterer1, 2. 1Center for Medical
Physics and Biomedical Engineering, Medical
University of Vienna, Vienna, Austria; 2Department
of Clinical Pharmacology, Medical University of
Vienna, Vienna, Austria
3384 — D0321 Blood-neural-barrier disruption
has different effects on fluorescein angiography
dynamics in the eye and brain. Flora Hui1, C. T.
Nguyen1, Z. He1, R. Gurrell2, R. Fish2, A. J. Vingrys1,
B. V. Bui1. 1University of Melbourne, Melbourne,
VIC, Australia; 2Neuroscience and Pain Research
Unit, Pfizer, Cambridge, United Kingdom *CR
Tuesday Posters
8:30 am – 10:15 am
3385 — D0322 Modeling and experimental
testing of iris thermal damage limits. David
Dewey, A. Vankov, G. Schuele. R&D, Abbott
Medical Optics, Sunnyvale, CA *CR
3386 — D0323 Measurement of Iris Lesion
Volume with Anterior Segment Swept-Source
Optical Coherence Tomography. Laura Vickers1,
H. AKIL1, 2, E. Baghdasaryan1, 2, O. L. Lee1, 2.
1
Ophthalmology, Doheny Eye Institute-UCLA,
Pasadena, CA; 2Doheny Image Reading Center,
Los Angeles, CA
3387 — D0324 Video imaging during
visual field perimetry. Jacques R. Charlier1, X.
Zanlonghi2. 1Research, Metrovision, Perenchies,
France; 2Clinique Sourdille, Nantes, France *CR
3388 — D0325 Ocular biometric parameters
variation between closed and opened angles in
Thai population. Kulawan Rojananuangnit, P.
Salyapongse. Ophthalmology, Mettapracharak(Wat
Rai Khing) hospital, Nakhon Pathom, Thailand
3389 — D0326 Novel fshape mapping of
peripapillary RNFL and choroidal thickness for
group-wise comparison of glaucoma and healthy
aging. Sieun Lee1, K. Popuri1, J. A. Matsubara2, B.
Eadie2, A. Merkur2, P. MacKenzie2, M. V. Sarunic1,
M. Beg1. 1Simon Fraser University, Vancouver,
BC, Canada; 2University of British Columbia,
Vancouver, BC, Canada
3390 — D0327 Imaging of scar tissue in the
filtering bleb by anterior-segment polarizationsensitive OCT. Masahiro Yamanari1, S. Tsuda2,
T. Kokubun2, 3, K. Omodaka2, Y. Yokoyama2, N.
Himori2, S. Kunimatsu-Sanuki2, K. Maruyama2,
H. Kunikata2, T. Nakazawa2. 1Tomey Corporation,
Nagoya, Japan; 2Department of Ophthalmology,
Tohoku University Graduate School of Medicine,
Sendai, Japan; 3Department of Ophthalmology,
Katta General Hospital, Shiroishi, Japan *CR
3391 — D0328 Assessment of diagnostic
information acquired by Transverse Section
Enhanced Depth Imaging Optical Coherence
Tomography in Patients with Optic Nerve Head
Drusen. Katharina Blobner, M. M. Maier, N.
Feucht. Department of Ophthalmology, Technische
Universität München, Munich, Germany
3392 — D0329 Three Dimension Spectral
Domain Optical Coherence Tomography: an
Important Tool for Diagnosis, Treatment and
Follow-up of Optic Disc Pit in Elderly Patients.
Luis Alberto Zeman Bardeci, M. Iglicki, M. Cotic,
M. Mendaro, L. Adamo, J. Bar, P. Chiaradia, M.
Zas. División Oftalmología, Hospital de Clínicas,
City of Buenos Aires, Argentina
3393 — D0330 Distinguishing Ischemic Optic
Neuropathy from Optic Neuritis by Ganglion
Cell Analysis. Carlos E. Mendoza1, 2, N. ErlichMalona1, N. Patel1, 3, C. Monaco1, E. Cole1,
T. Hedges1. 1New England Eye Center, Tufts
Medical Center. Tufts University, Boston, MA;
2
Neurology, New York University, New York, NY;
3
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL
3394 — D0331 RetinAsk Update: Image and
Image Analysis, Worth a Million Words? Jessica
Taibl, S. I. Sayegh. The EYE Center, Champaign, IL
3395 — D0332 Torsional Indirect Traumatic
Optic Neuropathy (TITON): Identifying
Biomarkers of Trauma using Matrix Assisted
Laser Desorption/Ionization (MALDI). Kirstin
Jones1, R. D. Glickman2, B. I. Asemota3, M. A.
Reilly1. 1Biomedical Engineering, UTSA, San
Antonio, TX; 2UTHSCSA, San Antonio, TX; 3St.
Louis University School of Medicine, St. Louis, MO
3396 — D0333 Thickness of the macula,
retinal nerve fiber layer, and ganglion cell-inner
plexiform layer in branch retinal vein occlusion :
the repeatability study of spectral domain optical
coherence tomography. Min Su Kim1, H. Lim1,
K. Shin1, J. Kim1, 2. 1Ophthalmology, Chungnam
National University College of Medicine, Daejeon,
Korea (the Republic of); 2R & D Division,
Chungnam Natl Univ Hosp, Daejeon, Korea (the
Republic of)
3397 — D0334 Predicting future visual
acuity outcomes from early morphologic and
functional response in anti-VEGF treated
retinal vein occlusion. Wolf-Dieter Vogl1, S. M.
Waldstein2, B. Gerendas2, T. Schlegl1, J. Wu2, D.
Podkowinski2, U. Schmidt-Erfurth2, G. Langs1.
1
Medical University of Vienna, Christian Doppler
Laboratory for Ophthalmic Image Analysis,
Department of Ophthalmology, Computational
Imaging Research Lab, Vienna, Austria; 2Medical
University of Vienna, Christian Doppler Laboratory
for Ophthalmic Image Analysis, Department of
Ophthalmology, Vienna Reading Center, Vienna,
Austria *CR
3398 — D0335 Evolution of Short-wavelength
Autofluorescence changes in Central Serous
Chorioretinopathy over 12 months. Marta
Zola3, P. Sanghi2, N. Patrao3, D. Menon3, P.
Hykin1, S. Sivaprasad1.1NIHR Moorfields
Biomedical Research Center, London, United
Kingdom; 2University College London, Institute
of Ophthalmology, London, United Kingdom;
3
Moorfields Eye Hospital, London, United Kingdom
*CR
3399 — D0336 New Public Retinal Image
Database for Tortuosity Evaluation. Jeffrey
C. Wigdahl1, R. Annunziata2, L. Hughes3, S.
Borooah4, A. Ruggeri1, E. Trucco2. 1Information
Engineering, University of Padova, Padova,
Italy; 2Vampire Project, School of Science and
Engineering (Computing), University of Dundee,
Dundee, United Kingdom; 3College of Medicine
and Veterinary Medicine, University of Edinburgh,
Edinbrugh, United Kingdom; 4Center for
Regenerative Medicine, University of Edinburgh,
Edinburgh, United Kingdom
3400 — D0337 A retrospective, observational
analysis of the impact of a telemedicine system to
identify ocular disease in patients with diabetes
mellitus screened in a non-eye care medical
setting. Ingrid E. Zimmer-Galler1, Y. Chu2, C. Y.
Weng2, J. A. Martinez3, S. gupta4. 1Clinical-Retina,
Johns Hopkins Medical Institutions, Baltimore,
MD; 2Baylor College of Medicine, Houston, TX;
3
Austin Retina, Austin, TX; 4Retinal Specialty
Institute, Pensacola, FL *CR
3401 — D0338 Quantitative Fundus
Autofluorescence (qAF) in Diabetic Patients.
Andrew Hsu, M. Ahmad, T. Smith. Ophthalmology,
New York University School of Medicine,
New York, NY
3402 — D0339 The prognostic effect of
peripheral non-perfusion on macular thickness
and visual acuity in diabetic and venous
occlusive retinopathies. Razek Georges Coussa, C.
Archambault, M. Mikhail, F. Antaki, D. E. Lederer.
Ophthalmology, McGill University, Montreal, QC,
Canada *CR
3403 — D0340 Automated Detection
and Classification of Longitudinal Retinal
Changes Due to Microaneurysms for Diabetic
Retinopathy Screening. Kedir Adal1, 3, P. van
Etten2, J. Martinez2, K. Rouwen2, L. Vliet3, K. A.
Vermeer1. 1Rotterdam Ophthalmic Inst, Rotterdam,
Netherlands; 2Rotterdam Eye Hospital, Rotterdam,
Netherlands; 3Delft University of Technology, Delft,
Netherlands
3404 — D0341 Combining Medical Data
and Fundus Images to Detect Eye Diseases in
Patients with Diabetes. Carla Agurto Rios1, S.
C. Nemeth1, G. Zamora1, W. Bauman2, P. Soliz1,
E. Barriga1.1VisionQuest Biomedical LLC,
Albuquerque, NM; 2Retina Institute of South Texas,
San Antonio, TX *CR
3405 — D0342 Fluorescence Lifetime Imaging
Ophthalmoscopy in Diabetic Retinopathy.
Martin Hammer1, 2, J. Schmidt1, S. Peters1, L.
Sauer1, N. Müller3, M. Klemm4, R. Augsten1, D.
Meller1.1Ophthalmology, University Hospital Jena,
Jena, Germany; 2Center for Medical Optics and
Photonics, Univ. of Jena, Jena, Germany; 3internal
Medicine, University Hospital Jena, Jena, Germany;
4
Technical University, Ilmenau, Germany
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
234
Tuesday – Posters – 3406 – 3414
3406 — D0343 Can Retinal Vascular
Geometry predict future progression of Diabetic
Retinopathy? Maged Habib2, B. Al-Diri1, R.
R. Crosby-Nwaobi3, S. Sivaprasad3, D. Steel2.
1
Computer Science, Lincoln University, Lincoln,
United Kingdom; 2Sunderland Eye Infirmary,
Sunderland, United Kingdom; 3Moorfields Eye
Hospital, London, United Kingdom
3414 — D0351 Comparison of Common
Radiographic Techniques in Identifying
Intraoperatively “Lost” Surgical Needles
and Vitrectomy Trocars. Yigit Akduman2, J. M.
Newman3, M. Zulfiqar1, E. I. Akduman1. 1Saint Louis
University, St. Louis, MO; 2Clayton High School,
St. Louis, MO; 3SureVision, St. Louis, MO
3407 — D0344 Atypical vascularization of
the foveal avascular zone in the human macula.
Delia DeBuc1, J. Tian1, T. R. Campagnoli1, W. Lee1,
H. Jiang1, J. Wang1, S. -. Reuven2, A. Grinvald5,
W. E. Smiddy1, G. M. Somfai3, 4. 1Ophthalmology,
University of Miami, Miami, FL; 2Optical Imaging,
Ltd, Rehovot, Israel; 3Retinology Unit, Pallas
Kliniken, Olten, Switzerland; 4Ophthalmology,
Semmelweis University, Budapest, Hungary;
5
Weizmann Institute of Science, Rehovot, Israel
*CR
Tuesday Posters
8:30 am – 10:15 am
3408 — D0345 Optical Coherence Tomography
Minimum Intensity as an objective measure for
the detection of hydroxychloroquine toxicity.
Ali M. Allahdina1, P. F. Stetson2, W. T. Wong1, E. Y.
Chew1, C. A. Cukras1. 1National Eye Institute, NIH,
Bethesda, MD; 2Research and Development, Carl
Zeiss Meditec, Dublin, CA *CR, f
3409 — D0346 Quantitative fundus
autofluorescence in patients treated with
hydroxychloroquine. Francesco Viola1, 2, M. Di
Nicola3, 2, E. Benatti3, 2, E. Tabacchi2, R. Clerici3, A.
Santaniello2, A. Invernizzi2.1Department of Clinical
Sciences and Community Health, University of
Milan, Milan, Italy; 2Fondazione IRCCS Cà Granda
Ospedale Maggiore Policlinico, Milan, Italy;
3
University of Milan, Milan, Italy
3410 — D0347 Lipofuscin RPE Imaging in
Vegetarians and Non-vegetarians: Dietary and
Age Effects. Pooja A. Padgaonkar, S. S. Kommana,
L. Wu, N. Mendez, B. C. Szirth, A. S. Khouri.
Rutgers-New Jersey Medical School, Newark, NJ
3411 — D0348 Retinal and choroidal features
in active posterior uveitis and panuveitis assessed
by swept-source optical coherence tomography.
Alfredo Adan Civera, J. Matas, A. De Pouplana,
V. Llorenç, M. Mesquida, A. Sala, M. Sainz de la
Maza, J. Zarranz-Ventura. Ophthalmology, Hospital
Clinic, Barcelona, Spain
3412 — D0349 Correlation In Retinal Nerve
Fiber Layer Thickness In Uveitis And Healthy
Eyes Using Scanning Laser Polarimetry And
Optical Coherence Tomography. David Bellocq,
L. Kodjikian, P. Denis. Ophthalmology, Croix
Rousse University Hospital, LYON, France
3413 — D0350 Ultra-Widefield Fluorescein
Angiography in Intermediate Uveitis. Wipada
Laovirojjanakul, N. Acharya, J. A. Gonzales.
Uveitis, Francis I. Proctor Foundation, UCSF, San
Francisco, CA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
235
Tuesday – General Business Meeting
Room 618/620
Tuesday, May 03, 2016 10:15 AM-10:55 AM
326 General Business Meeting
- Welcome - ARVO President, Dr. John Clark, MD,
FARVO
- Presentation of ARVO Distinguished Service
Awards - ARVO President, Dr. John Clark, MD,
FARVO
- Dr. William Mieler, MD, FARVO
- Dr. Dimitri Azar, MD, MBA, FARVO
- Dr. Linda McLoon, PhD, FARVO
- Presentation of the Joanne G. Angle Award to Dr.
Sheila West, PhD, FARVO - ARVO President Dr.
John Clark, MD, FARVO
Tuesday General
Business Meeting
10:15 am – 10:55 am
- Presentation of the VSS Award to Kavitha
Ratnam, BSc, - ARVO President Dr. John Clark,
MD, FARVO
- Presentation of Certificate of Appreciation to Dr.
David Huang for his outstanding contributions
to ARVO’s “Telling the Story of OCT” Project ARVO President, Dr. John Clark, MD, FARVO
- Presentation of the David L. Epstein Award to
Dr. Jonathan G. Crowston, MBBS, PhD - ARVO
Foundation Chair, Dr. Mark Petrash, PhD, FARVO
- Presentation of Membership Update and Election
Results - ARVO Executive Vice President, Dr. Craig
E. Crosson, PhD, FARVO
- Introduction of Incoming Officers - ARVO
Executive Vice President, Dr. Craig E. Crosson,
PhD, FARVO
- Dr. Crosson presents the membership and annual
meeting attendance update
- Dr. Crosson presents the election results for EVP
and EIC positions
- Dr. Crosson presents the 2016-2017 Board officers
- Conclude Meeting - ARVO Executive Vice
President, Dr. Craig E. Crosson, PhD, FARVO
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
236
Tuesday – Papers/Minisymposium – 3415 – 3427
Room 6A
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Glaucoma
327 Glaucoma Visual Fields and
Visual Function
Moderators: Allison M. McKendrick and
Lyne Racette
3415 — 11:00 The effect of ametropia on
glaucomatous visual field loss. Tobias Elze1, 2, L.
Shen3, M. Wang1, M. V. Boland4, S. Wellik5, C. De
Moraes6, J. S. Myers8, P. Bex7, L. R. Pasquale3.
1
Schepens Eye Research Institute, Harvard Medical
School, Boston, MA; 2Max Planck Institute for
Mathematics in the Sciences, Leipzig, Germany;
3
Massachusetts Eye and Ear Infirmary, Harvard
Medical School, Boston, MA; 4Wilmer Eye
Institute, Johns Hopkins University School of
Medicine, Baltimore, MD; 5Bascom Palmer Eye
Institute, Miami, FL; 6Edward S. Harkness Eye
Institute, Columbia University Medical Center,
New York, NY; 7Northeastern University, Boston,
MA; 8Wills Eye Hospital, Philadelphia, PA *CR
3417 — 11:30 The Influence of Perimetric
Stimulus Size on Defect Detectability in Early
Glaucoma. John G. Flanagan1, P. H. Artes2,
M. Wall3, E. Young4, T. Callan4, V. Patella4, M.
Monhart4, 5, G. C. Lee4. 1School of Optometry and
Vision Science, University of California Berkeley,
Berkeley, CA; 2Plymouth University, Plymouth,
United Kingdom; 3University of Iowa, Iowa City,
IA; 4Carl Zeiss Meditec, Dublin, CA; 5Carl Zeiss
AG, Feldbach, Switzerland *CR
3418 — 11:45 Cognitive Decline is Associated
with Increased Visual Field Variability in
Glaucoma. Maria Valeria C. Silva1, 2, A. DinizFilho1, 2, S. Cronemberger2, F. A. Medeiros1.
1
Laboratory of Performance and Visual Function,
Department of Ophthalmology, University of
California San Diego, La Jolla, CA; 2Department of
Ophthalmology and Otorhinolaryngology, Federal
University of Minas Gerais, Belo Horizonte,
Brazil*CR
3420 — 12:15 Relationship between Subjective
Driving Concerns and Objective Driving
Performance on a Simulator in Patients with
Glaucomatous Visual Field Loss. Priscila C.
Correa1, 2, C. P. Gracitelli1, 2, E. R. Boer1, A.
Diniz-Filho1, A. Paranhos Jr.2, F. A. Medeiros1.
1
Laboratory of Performance and Visual Fuction,
Department of Ophthalmology, University of
California San Diego, La Jolla, CA; 2Departament
of Ophthalmology, Federal University of São Paulo,
São Paulo, Brazil *CR
3421 — 12:30 Predicting Patient-Reported
Disability in Glaucoma from Results of Standard
Automated Perimetry. Ricardo Y. Abe1, 2, A.
Diniz-Filho1, C. P. Gracitelli1, F. A. Medeiros1.
1
Laboratory of Performance and Visual Function,
Department of Ophthalmology, University of
California San Diego, La Jolla, CA; 2Department
of Ophthalmology, University of Campinas UNICAMP, Campinas, Brazil *CR
Room 6B
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Retina
328 OCT Angiography 2
Moderators: Philip J. Rosenfeld and
Richard B. Rosen
3422 — 11:00 The features of age-related
macular degeneration imaged by optical
coherence tomography based angiography.
Ruikang K. Wang1, Q. Zhang1, C. S. Lee1, K.
Attaran-Rezaei1, P. J. Rosenfeld2.1Ophthalmology,
University of Washington, Seattle, WA; 2Bascom
Palmer Eye Insitute, University of Miami Miller
School of Medicine, Miami, FL *CR
3424 — 11:30 Angiographic optical coherence
tomography (OCT) of subretinal hyperreflective
material (SHRM). Kunal K. Dansingani1, 5, F.
Gilani1, 5, N. Phasukkijwatana2, 6, E. A. Novais3, L.
Querques4, D. Sarraf2, 7, N. K. Waheed3, J. S. Duker3,
G. Querques4, L. Yannuzzi1, 5, K. Freund1, 5. 1Vitreous
Retina Macula Consultants of New York, New York,
NY; 2Stein Eye Instutute UCLA, Los Angeles, CA;
3
New England Eye Center, Tufts University School
of Medicine, Boston, MA; 4University Vita-Salute
San Raffaele, IRCCS Ospedale San Raffaele, Milan,
Italy; 5LuEsther T. Mertz Retinal Research Center,
New York, NY; 6Department of Ophthalmology,
Faculty of Medicine, Siriraj Hospital, Mahidol
University, Bangkok, Thailand; 7Stein Eye
Institute, Greater Los Angeles VA Health Center,
Los Angeles, CA *CR
3425 — 11:45 OCT-based angiography of
choroidal neovascularization by removing
projection artifacts. Qinqin Zhang1, A. Zhang1, C.
S. Lee1, A. Lee1, L. Roisman2, G. Gregori2, M. K.
Durbin3, L. An3, P. F. Stetson3, P. J. Rosenfeld2, R.
K. Wang1. 1University of Washington, Seattle, WA;
2
Bascom Palmer Eye Insitute, Miami, FL; 3Carl
Zeiss Meditec. Inc, Dublin, CA *CR
3426 — 12:00 A Comparison of Optical
Coherence Tomography Angiography to
Fluorescein Angiography for the Imaging of
Type 1 Neovascularization. Maiko Inoue1, 2, J. J.
Jung3, 2, C. Bala2, 4, T. E. de Carlo5, A. Shahlaee6,
M. A. Klufas8, J. S. Duker5, A. C. Ho6, M. Quaranta
El-Maftouhi7, D. Sarraf8, K. Freund2, 4. 1Yokohama
City University Medical Center, Yokohama, Japan;
2
Vitreous Retina Macula Consultants of New York,
New York, NY; 3East Bay Retina Consultants,
Inc., Oakland, CA; 4The LuEsther T. Mertz Retinal
Research Center, Manhattan Eye, Ear and Throat
Hospital, New York, NY; 5New England Eye Center
and Tufts Medical Center, Tufts University, Boston,
MA; 6Mid Atlantic Retina, The Retina Service of
Wills Eye Hospital, Thomas Jefferson University,
Philadelphia, PA; 7Centre Ophtalmologique
Rabelais, Lyon, France; 8Stein Eye Institute at
UCLA, Los Angeles, CA *CR
3427 — 12:15 Sensitivity and specificity of
choroidal neovascularization detection in agerelated macular degeneration with optical
coherence tomography angiography. Ambar
Faridi1, 2, Y. Jia1, S. S. Gao1, K. Bhavsar1, 2, D. J.
Wilson1, A. Sill1, C. J. Flaxel1, T. S. Hwang1, A.
Lauer1, D. Huang1, S. T. Bailey1. 1Ophthalmology,
Oregon Health & Science University, Casey Eye
Institute, Portland, OR; 2Ophthalmology, VA
Portland Health Care System, Portland, OR *CR
3423 — 11:15 Exploring choriocapillaris under
reticular pseudodrusen using OCT-Angiography.
Florian Alten, P. Heiduschka, C. R. Clemens,
N. Eter. Ophthalmology, University Eye Hosp
Muenster, Muenster, Germany *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
237
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3416 — 11:15 Disrupted Ocular Motor
Behaviour in Preperimetric Glaucoma. Dan
Milea1, S. Sharma1, M. Drouet2, S. Leruez2, M.
Baskaran3, M. E. Nongpiur3, T. Aung5, O. White4, C.
Lamirel6. 1Visual Neuroscience Group, Singapore
Eye Research Institute, Singapore, Singapore;
2
University Angers, Angers, France; 3SERI,
Singapore, Singapore; 4University of Melbourne,
Melbourne, SA, Australia; 5Singapore Eye Research
Institute, Singapore, Singapore; 6Fondation
Rothschild, Paris, France
3419 — 12:00 Detection of Glaucoma
Progression is Delayed in African Descent
Compared to European Descent Subjects.
Carolina P. Gracitelli1, 2, L. M. Zangwill1, A.
Diniz-Filho1, R. Y. Abe1, R. N. Weinreb1, C.
A. Girkin3, J. M. Liebmann4, F. A. Medeiros1.
1
Hamilton Glaucoma Center, Shiley Eye Institute,
Department of Ophthalmology, University of
California San Diego, La Jolla, CA; 2Department of
Ophthalmology, Federal University of Sao Paulo,
Sao Paulo, Brazil; 3School of Medicine, University
of Alabama, Birmingham, Alabama, Birmingham,
AL; 4Harkness Eye Institute, Columbia University
Medical Center, New York, New York., New York,
NY *CR
3428 – 3444 – Tuesday – Papers/Minisymposium
3428 — 12:30 Optical Coherence Tomography
Angiography of Choroidal Neovascularization
and Inflammatory Pigment Epithelial
Detachments Occurring in Idiopathic
Multifocal Choroiditis. Sarwar Zahid1, J. J.
Jung2, K. C. Chen1, T. R. Kaden1, Q. Ghadiali3, C.
Bala3, S. Rofagha2, K. Freund3, 1, L. Yannuzzi3, 1.
1
Ophthalmology, New York University, New York,
NY; 2East Bay Retina Consultants, Inc., Oakland,
CA;3Vitreous Retina Macula Consultants of
New York, New York, NY
Room 6C
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Retina
329 Retinal Vascular Diseases
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
Moderators: Susumu Ishida and
Baruch D. Kuppermann
3429 — 11:00 Retinal non-perfusion
in the posterior pole determines risk of
neovascularisation in central retina vein
occlusion. Luke Nicholson, C. Vazquez-Alfageme,
N. V. Patrao, I. Triantafyllopoulou, P. Hykin, S.
Sivaprasad. NIHR Moorfields Biomedical Research
Centre and UCL Institute of Ophthalmology,
London, United Kingdom *CR
3430 — 11:15 Impact of initial visual acuity
on anti-VEGF treatment outcomes in patients
with macular edema secondary to retinal vein
occlusions. Karen M. Wai1, 2, M. Khan1, F. Silva1,
S. K. Srivastava1, J. P. Ehlers1, A. Rachitskaya1,
P. K. Kaiser1, A. Schachat1, A. Babiuch1, A. Yuan1,
R. Singh1. 1Cole Eye Institute, Cleveland Clinic,
Cleveland, OH; 2Case Western Reserve University
School Of Medicine, Cleveland, OH *CR
3431 — 11:30 Effect of intravitreal
dexamethasone implant on intraocular
cytokines and chemokines in eyes with branch
and central retinal vein occlusion. Sandra
Rezar2, K. Eibenberger2, A. Pollreisz2, W. Buehl2,
M. Georgopoulos2, C. Krall1, G. Weigert2, U.
Schmidt-Erfurth2, S. Sacu2. 1Department of Medical
Statistics, Medical University of Vienna, Vienna,
Austria; 2Department of Ophthalmology, Medical
University of Vienna, Vienna, Austria *CR, f
3432 — 11:45 Safety and efficacy of
ranibizumab 0.5 mg vs dexamethasone 0.7 mg
intravitreal implant in patients with branch
or central retinal vein occlusion: long-term
results of the COMRADE-Extension study.
Nicolas Feltgen1, T. Bertelmann2. 1Ophthalmology,
University Hospital, Goettingen, Germany;
2
Clinical Research Retina, Novartis Pharma GmbH,
Nuernberg, Germany *CR, f
3433 — 12:00 A Novel Experimental Model
for Investigating the Role of Microglial Cells in
Retinal Edema. Hannah Canter1, A. C. Palacio1,
H. Lu1, B. G. Borghuis2, S. Schaal1. 1Department
of Ophthalmology and Visual Scineces, University
of Louisville School of Medicine, Louisville,
KY; 2Department of Anatomical Sciences and
Neurobiology, University of Louisville School of
Medicine, Louisville, KY
3434 — 12:15 Novel software to assess
correlation between MAIA microperimetry
and OCT imaging of ellipsoid zone in type 2
idiopathic macular telangiectasia. Eleonora M.
Lad1, D. Mukherjee1, R. R. Vann2, T. E. Clemons3, E.
Y. Chew4, G. J. Jaffe1, S. Farsiu5. 1Ophthalmology,
Duke Eye Center, Durham, NC; 2Research Triangle
High School, Durham, NC; 3Ophthalmology,
EMMES, Rockville, MD; 4Division of
Epidemiology and Clinical Applications, National
Eye Institute, Bethesda, MD; 5Biomedical
Engineering, Duke University Medical Center,
Durham, NC *CR, f
3435 — 12:30 Biological rationale for the
clinical effect of aflibercept in patients with
idiopathic macular telangiectasia type 1. Laura
Kowalczuk1, A. Dirani1, A. Matet1, A. Daruich1,
A. Ambresin1, I. Mantel1, N. Turck2, F. F. BeharCohen1. 1Department of ophthalmology, Jules Gonin
eye hospital, University of Lausanne, Fondation
Asile des aveugles, Lausanne, Switzerland;
2
Department of Human Protein Science, University
of Geneva, Geneva, Switzerland
3439 — 11:45 Microvascular responses of
the bulbar conjunctiva in dry eye. Alexandra
Levitt1, W. Chen1, 2, A. Galor1, 4, J. Yuan1, 2, C. D.
Sarantopoulos4, 3, N. Shalabi1, 4, H. I. Batawi1, 4, A. L.
McClellan4, W. J. Feuer1, R. C. Levitt4, 3, J. Wang1.
1
Bascom Palmer Eye Institute, University of Miami,
Miami, FL; 2Zhongshan Ophthalmic Centre, Sun
Yat-sen University, Guangzhou, China; 3Department
of Anesthesiology, Perioperative Medicine and Pain
Management, University of Miami, Miami, FL;
4
Miami Veterans Administration Medical Center,
Miami, FL *CR
3440 — 12:00 Effects of punctal occlusion
on tear protein levels in dry eye patients. Louis
Tong1, L. Zhou1, R. W. Beuerman1, S. Simonyi2, D. A.
Hollander2, M. E. Stern3. 1Singapore National Eye
Centre, Singapore, Singapore; 2Allergan plc, Irvine,
CA; 3Baylor College of Medicine, Mission Viejo,
CA *CR, f
3441 — 12:15 Evaluation for Dropout Lesions
on Infrared Meibography Using Optical
Coherence Tomography Meibography. YoungSik Yoo1, Y. Byon1, C. Joo1, G. Yoon2. 1The Catholic
University of Korea, Seoul, Korea (the Republic
of); 2Rochester University, Rochester, NY
3442 — 12:30 Tear Lipid Layer Thickness
and Variability Both Impact Tear Film
Stability. Meng C. Lin1, 2, A. D. Graham2, P.
Satjawatcharaphong2, W. Li1, 2, T. N. Yeh1, 2, M.
Lerma2, K. Lin2. 1Vision Science Graduate Group,
University of California, Berkeley, CA; 2Clinical
Research Center, School of Optometry, University
of California, Berkeley, CA
Room 606/607
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Room 609
Cornea
Tuesday, May 03, 2016 11:00 AM-12:45 PM
330 Dry Eye; Clinical and Epidemiology
Moderators: Kyoungyul Seo and Penny A. Asbell
3436 — 11:00 Remote Assessment of Dry Eye
Symptoms using two Web-Based Questionnaires.
Francisco Amparo, R. Dana. Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA
3437 — 11:15 Association between Air
Pollution and Dry Eye Disease in South Korea.
Dong Hyun Kim1, S. Hwang1, Y. Choi2. 1Department
of Ophthalmology, Gachon University Gil
Medical Center, Incheon, Korea (the Republic
of); 2Department of Preventive Medicine, Gachon
University College of Medicine, Incheon, Korea
(the Republic of)
3438 — 11:30 Does dry eye severity correlate
with somatosensory function in the V1
distribution of the trigeminal nerve? Anat
Galor2, 1, B. Seiden2, K. T. McManus2, J. J. Park2,
R. C. Levitt3, C. D. Sarantopoulos3, E. Felix4.
1
Ophthalmology, Bascom Palmer, Miami, FL;
2
Ophthalmology, Miami VAMC, Miami, FL;
3
Anesthesiology, Miami VAMC, Miami, FL;
4
Research Services, Miami VAMC, Miami, FL
Lens
331 Lens Development
Moderators: Jeffrey M. Gross and
Judith A. West-Mays
3443 — 11:00 RNA sequencing analysis of Celf1
mouse mutants identifies a cohort of abnormally
expressed lens development regulators.
Archana D. Siddam1, D. Anand1, L. Paillard3,
S. A. Lachke1, 2.1Dept of Biological Sciences,
University of Delaware, Hockessin, DE; 2Center
for computational biology and bioonformatics,
University of Delaware, Newark, DE; 3institut de
génétique et développement de rennes, Rennes,
France
3444 — 11:15 Anisotropic geometry of lens
placode cells is mediated by planar polarized
inhibition of junctional contraction during
invagination. Timothy F. Plageman. College of
Optometry, The Ohio State University, Columbus,
OH
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
238
Tuesday – Papers/Minisymposium – 3445 – 3462
3445 — 11:30 Conditional Deletion of
Apaf-1 Disrupts Mouse Lens and Anterior
Segment Development. Lixing W. Reneker, L.
Wang, G. Chandran, A. Lueckenotte, R. Irlmeier.
Ophthalmology, University of Missouri-Columbia,
Columbia, MO
3446 — 11:45 Functional Dissection Shows
FOXE3 Contributes to Peters Anomaly
through the Transcriptional Regulation of an
Autophagy Associated Co-Chaperone, DNAJB1.
Shahid Y. Khan1, S. Vasanth1, F. Kabir1, A. O.
Khan2, Z. Ma3, S. Riazuddin4, 5, N. Pourmand6,
N. A. Zaghloul7, J. Hejtmancik3, S. Riazuddin1.
1
The Wilmer Eye Institute, Johns Hopkins
University School of Medicine, Baltimore,
MD; 2Pediatric Ophthalmology, King Khaled
Eye Specialist Hospital, Riyadh, Saudi Arabia;
3
Ophthalmic Genetics and Visual Function
Branch, National Eye Institute, Bethesda, MD;
4
National Centre of Excellence in Molecular
Biology, University of the Punjab, Lahore,
Pakistan; 5National Centre for Genetic Diseases,
Shaheed Zulfiqar Ali Bhutto Medical University,
Islamabad, Pakistan; 6Biomolecular Engineering,
University of California, Santa Cruz, Santa Cruz,
CA;7Department of Medicine, University of
Maryland, Baltimore, MD
3448 — 12:15 Functional Assessment of
FYCO1 Underlines the Association with
Autophagy and Confirms the Indispensable
Role in Lens Development. Firoz Kabir1, S. Y.
Khan1, S. Riazuddin2, 4, J. Akram3, 4, J. Hejtmancik5,
S. Riazuddin1. 1The Wilmer Eye Institute, Johns
Hopkins University School of Medicine, Baltimore,
MD; 2National Centre of Excellence in Molecular
Biology, University of the Punjab, Lahore,
Pakistan;3Allama Iqbal Medical College, University
of Health Sciences, Lahore, Pakistan; 4National
Centre for Genetic Diseases, Shaheed Zulfiqar Ali
Bhutto Medical University, Islamabad, Pakistan;
5
Ophthalmic Genetics and Visual Function Branch,
National Eye Institute, Bethesda, MD
3449 — 12:30 ADAM10 is a key regulator of
NOTCH signaling. D J. Sidjanin1, 3, J. Toonen2.
1
Cell Biology, Neurobiology and Anatomy, Medical
College of Wisconsin, Milwaukee, WI; 2Neurology,
Washington University School of Medicine, St.
Louis, MO; 3Human and Molecular Genetics
Center, Medical College of Wisconsin,
Milwaukee, WI
Room 615/617
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Visual Psychophysics/Physiological Optics /
Clinical/Epidemiologic Research /
Eye Movements/Strabismus/Amblyopia/NeuroOphthalmology / Retina
Physiology/Pharmacology
332 Optics of the eye and vision Minisymposium
Moderator: Haydee E. Bazan
Optics of the eye is the most important first step
for vision which has been studied objectively
using various methods to quantify optical quality
of the eye. How the visual system perceives the
retinal images formed through the eye’s optics is
an intriguing question to ask. This minisymposium
proposes to advance our understanding of how
optics of the eye affects neural processing of retinal
image quality and emmetropization.
Moderators: Thomas W. Raasch and
Geunyoung Yoon
3450 — 11:00 Introduction. Thomas W. Raasch.
Ohio State University, Columbus, OH
3451 — 11:05 Neural mechanism of long-term
adaptation to the eye’s aberration. Geunyoung
Yoon. Flaum Eye Institute, University of Rochester,
Rochester, NY; Center for Visual Science,
University of Rochester, Rochester, NY
3452 — 11:25 Neural interpretation of optical
blur and its impact on image quality perception.
Susana Marcos. Instituto de Optica, CSIC, Madrid,
Spain
3453 — 11:45 Peripheral optics of the eye
and its relevance to visual performance and
refractive error development. David A. Atchison.
Queensland University of Technology, Brisbane,
QLD, Australia
3454 — 12:05 Binocular combination of
different monocular optical blurs. Martin Banks.
Optometry & Vision Science, UC Berkeley,
Berkeley, CA
3455 — 12:25 Comparison of different
binocular approaches to overcome presbyopia.
Pablo Artal. Lab. Optica, Universidad de Murcia,
Murcia, Spain *CR
333 Drug Delivery
3456 — 11:00 Determination of the effect
size of conjunctival and episcleral circulation
on transscleral drug delivery. Bing Gu1, X. Li1,
J. Liu1, X. Ding1, L. Cheng1, 2. 1Institute of Ocular
Pharmacology, School of Ophthalmology and
Optometry, Wenzhou Medical University, Wenzhou,
China; 2Department of Ophthalmology, University
of California San Diego, Jacob’s Retina Center at
Shiley Eye Institute, San Diego, CA
3457 — 11:15 Dendrimer Nanofibers for
Ocular Drug Delivery. Michael G. Lancina1,
S. Husain2, S. Singh2, H. Yang3. 1Biomedical
Engineering, Virginia Commonwealth University,
Richmond, VA; 2Ophthalmology, Medical
University of South Carolina, Charleston, SC;
3
Chemical and Life Science Engineering, Virginia
Commonwealth University, Richmond, VA
3458 — 11:30 MiDROPS™ for Topical
Delivery of Lipophilic Compounds to the
Anterior and Posterior Segment of the Eye.
Drew Wassel, C. Calbert, D. Nuno, A. Quiambao, J.
Green, P. Vanlandingham, A. Dockins, A. Sparkes,
E. Phelps, M. Lambros, R. Farjo. EyeCRO,
Oklahoma City, OK
3459 — 11:45 Selective Episcleral
Drug Delivery of Neuroprotective Drugs.
Toxicokinetics of a Neuroprotective Estradiol
Analog and Implications for Treatment of
Traumatic and Neurodegenerative Ocular
Conditions. Jacques Manders, J. Moreno, R. brito,
M. C. Vargas-Dougherty, P. P. Ko, C. Mendes, G.
C. Matsutani, R. A. De Carvalho. 3t Ophthalmics,
Irvine, CA *CR
3460 — 12:00 An Injectable, Biodegradable,
And Biocompatible Reverse Thermal Gel
Designed for Controlled, Intra-vitreal Drug
Delivery. yadong wang, T. R. Friberg, M. Sinha,
H. Awada, X. Ding. university of pittsburgh,
Pittsburgh, PA
3461 — 12:15 Intraocular Sustained Delivery
System Of Flurbiprofen; Efficacy And
Pharmacokinetics. Miltiadis K. Tsilimbaris1,
S. Blazaki1, C. Tsika1, K. Pachis2, I. Naoumidi1,
C. Tsatsanis1, M. Tzatzarakis1, S. Antimisiaris2.
1
Medicine, University of Crete, Heraklion, Greece;
2
Pharmacology, University of Patras, Patras, Greece
3462 — 12:30 Intranasal delivery of
nanomicelle curcumin promotes corneal
epithelial wound healing in streptozotocininduced diabetic mice. Xianggen Wu, C. Guo,
M. Li, X. Qi, F. Cui, F. Li. Shandong Eye Institute,
Qingdao, China
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
239
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3447 — 12:00 β1-integrin deletion from lens
activates AKT signaling and EGR1 expression in
the epithelium leading to fibrosis and apoptosis.
Yichen Wang, A. M. Terrell, D. Anand, S. A. Lachke,
M. K. Duncan. University of Delaware, Newark, DE
Room 611/612
3463 – 3477 – Tuesday – Papers/Minisymposium
Room Skagit 4/5, TCC
Room Tahoma 1/2, TCC
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Immunology/Microbiology / Clinical/
Epidemiologic Research / Cornea / Lens /
Physiology/Pharmacology / Retina
Retinal Cell Biology
334 Eye and pregnancy Minisymposium
There are physiological and immunological changes
in the eye during pregnancy. Pregnancy also
modifies the course of eye diseases or the indication
for surgery (e.g. diabetic retinopathy, refractive
surgery). In the end therapy during pregnancy is
a challenge for both the ophthalmologist and the
patient. There is uncertainty how to handle eye
diseases in pregnant patients and also how to treat
them without hazard to the unborn. The proposed
minisymposium will present the latest state of
knowledge regarding eye, immune system and
pregnancy.
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
Moderators: Friederike Mackensen, Thomas Ness
and Lyndell L. Lim
3463 — 11:00 Physiological changes during
pregnancy and mode of delivery. Thomas Ness.
Eye Center, University of Freiburg, Freiburg,
Germany *CR
3464 — 11:15 Immunity during pregnancy.
David Klatzmann. University of Pierre and
Marie Curie, Paris, France; Assistance Publique Hôpitaux de Paris, Paris, France
3465 — 11:45 Retina diseases in pregnancy.
Emily Y. Chew. National Eye Inst/NIH, Bethesda, MD
3466 — 12:00 Uveitis in pregnancy. Lyndell L.
Lim. Centre for Eye Research Australia, University
of Melbourne, Melbourne, VIC, Australia *CR
3467 — 12:15 Prenatal exposure in pregnancy:
what ophthalmologists need to know. Christina
D. Chambers. Pediatrics, University of California
San Diego, La Jolla, CA; Family Medicine and
Public Health, University of California San Diego,
La Jolla, CA
335 Photoreceptor degeneration, rescue
and live imaging
Moderator: Michael Robichaux
3468 — 11:00 Mutation in human retinal
membrane guanylyl cyclase 1 (RetGC1,
GUCY2D) associated with CORD6 deregulates
cGMP synthesis in photoreceptors and causes
progressive blindness in transgenic mouse
model. Alexander M. Dizhoor, E. V. Olshevskaya, I. V.
Peshenko. Research, Salus University, Elkins Park, PA
3469 — 11:15 A novel, safe, non-invasive
method to detect dying photoreceptors in the
living rat. Francesca Mazzoni, C. Müller, S. C.
Finnemann. Department of Biological Sciences,
Center for Cancer, Genetic Diseases and Gene
Regulation, Fordham University, Bronx, NY
3470 — 11:30 Interleukin-17 (IL-17) in Models
of Retinal and RPE Degeneration. Jiyang Cai1,
J. Chen1, P. Xu1, Z. Zhao1, Y. Cong2, Y. Chen1.
1
Ophthalmology, University of Texas Medical
Branch, Galveston, TX; 2Microbiology and
Immunology, University of Texas Medical Branch,
Galveston, TX
3471 — 11:45 The neuroprotective effects
of PARP inhibition in different types of
photoreceptor degeneration. Ayse Sahaboglu1,
S. Vagionitis2, A. Sharif3, M. Barth2, K. jiao4, M.
Kulkarni1, D. Trifunovic1, M. Ueffing1, E. Zrenner1,
F. Paquet-Durand1. 1Division of Experimental
Ophthalmology, Institute of Ophthalmic Research,
Tubingen, Germany; 2Graduate School of
Cellular and Molecular Neuroscience, Tubingen,
Germany;3Weizmann Institute of Science, Rehovot,
Israel; 4The 2nd People’s Hospital of Yunnan
Province, Kunming, China
3472 — 12:00 Inactivation of Hif1a rescues
rods and cones from degeneration induced by
a chronic hypoxia-like response: HIF1A as
therapeutic target in AMD? Christian Grimm1,
M. Barben1, D. Ail1, B. Kast1, C. Schori1, C. GigerLange1, S. Michalakis2, M. Samardzija1. 1Lab for
Retinal Cell Biol, Ophthalmology, University of
Zurich, Schlieren / Zurich, Switzerland; 2Center for
Integrated Protein Science Munich (CIPSM) and
Department of Pharmacy-Center for Drug Research,
Ludwig-Maximilians-Universität München,
Munich, Germany
3473 — 12:15 Missing Motility: Highresolution in vivo imaging of retinal microglia
reveals stationary ramified cells. Eric Miller1, P.
Zhang2, 3, M. Goswami2, 3, R. J. Zawadzki3, 4, E. N.
Pugh3, 2, M. E. Burns1, 4. 1Center for Neuroscience,
UC Davis, Davis, CA; 2Cell Biology and Human
Anatomy, UC Davis, Davis, CA; 3EyePod Rodent
Imaging Laboratory, UC Davis, Davis, CA;
4
Ophthalmology and Vision Science, UC Davis,
Davis, CA
3474 — 12:30 Investigating the molecular
mechanisms of Late-Onset Retinal Degeneration
using patient-specific induced pluripotent stem
cells. Zoya Qureshy1, K. Miyagishima2, K. CloreGronenborn1, C. Zhang2, R. Sharma1, V. Rajan1,
V. Khristov2, C. Cukras3, S. S. Miller2, K. Bharti1.
1
Unit on Ocular Stem Cell and Translational
Research, National Eye Institute, National Institutes
of Health, Bethesda, MD; 2Section on Epithelial
& Retinal Physiology & Disease, National Eye
Institute, National Institutes of Health, Bethesda,
MD; 3Clinical Trials Branch, National Eye Institute,
National Institutes of Health, Bethesda, MD
Room Tahoma 3, TCC
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Cornea
336 Corneal Wound Repair and
Regenerative Medicine
Moderators: James D. Zieske and Che J. Connon
3475 — 11:00 Adipose-derived Mesenchymal
Stem Cells Therapy for Cornea Regeneration:
A Multi-photon Intravital Study in a Mouse
Model. Ladan Espandar1, J. Mandell1, T. Blanco2.
1
University of Pittsburgh, Pittsburgh, PA; 2Duke
University, Durham, NC
3476 — 11:15 Mesenchymal stem cells restore
corneal transparency via secretion of hepatocyte
growth factor. Sharad Mittal, A. Amouzegar,
M. Omoto, S. Chauhan. Schepens Eye Research
Institute, Harvard Medical School, Boston, MA *CR
3477 — 11:30 Extracellular vesicles derived
from human mesenchymal stem cells promote
corneal wound repair by increasing epithelial cell
proliferation and reducing neovascularisation in
a rat corneal alkali burn model. Thomas Ritter1,
C. Lal2, O. Treacy1, G. A. O’Malley1, S. Naicker1, H.
Elbadawy3, A. E. Ryan1, G. Fahy4, M. J. Leahy2, M.
Griffin1, S. Rani1. 1Regenerative Medicine Institute,
Nt’l Univ of Ireland, Galway, Galway, Ireland;
2
School of Physics, College of Natural Sciences,
National University of Ireland, Galway, Ireland,
Galway, Ireland; 3The Veneto Eye Bank Foundation,
Venice, Italy; 4Department of Ophthalmology,
University Hospital Galway, National University of
Ireland, Galway, Ireland, Galway, Ireland
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
240
Tuesday – Papers/Minisymposium – 3478 – 3488
3478 — 11:45 The Effect of Bone Marrow
Mesenchymal Stem Cell Secretome on Corneal
Epithelial Wound Healing. Medi Eslani1, A.
Movahedan1, I. Putra1, J. Hamouie1, A. Tadepalli1,
X. Shen1, N. Afsharkhamseh1, E. Ghahari1, P.
Hematti2, A. R. Djalilian1. 1Ophthalmology and
Visual Sciences, University of Illinois at Chicago,
Chicago, IL; 2Division of Hematology/Oncology,
Department of Medicine, University of Wisconsin
School of Medicine and Public Health,
Madison, WI
3479 — 12:00 Somatic Gene Therapy of
Mucopolysaccharidosis with CRISPR/Cas9
Genome Editing. Winston W. Kao1, T. Ferreira1, F.
Dong1, Y. Hu2, M. K. Call1, V. J. Coulson-Thomas1,
J. Zhang1, T. Rice1. 1Ophthalmology, University
of Cincinnati, Cincinnati, OH; 2Developmnetal
biology, Cincinnati Children’s Hospital medical
Center, Cincinnati, OH
3480 — 12:15 Quercetin inhibits corneal
scar formation in vivo. Dimitrios Karamichos1,
P. Kivanany2, T. B. McKay1, M. Petroll2.
1
Ophthalmology, Dean McGee Eye Institute/
OUHSC, Oklahoma city, OK;2University of Texas
Southwestern Medical Center, Dallas, TX
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Biochemistry/Molecular Biology
337 Next generation sequencing:
What’s next? - Minisymposium
High-throughput sequencing approaches of
targeted, whole exome, and whole genome next
generation sequencing (NGS) have been successful
in identifying known and novel genes underlying
inherited eye disorders. Determining the prevalence
of gene defects, advancing the molecular biologic
and pathway underpinnings and developing new
drug targets for therapeutic trials are potential
outcomes of this technology.
Moderators: Christina Zeitz, Qingjiong Zhang and
Marina S. Gorbatyuk
— 11:00 Introduction
3482 — 11:04 Exome sequencing identifies
novel gene defect in achromatopsia. Susanne
Kohl. Inst for Ophthalmic Rsrch Tuebingen,
Tuebingen, Germany
3483 — 11:18 Non-coding cis-acting genetic
defects in inherited blindness: from targeted
locus resequencing to interpretation. Elfride
De Baere. Center for Medical Genetics, Ghent
University and Ghent University Hospital, Ghent,
Belgium
3484 — 11:32 Identifying elusive molecular
defects underlying inherited retinal diseases
employing stem cell technology and
transcriptomics. Frans P. Cremers. Raboud
university medical center, Nijmegen, Netherlands
3485 — 11:46 Bioinformatics prediction
tools to help validating gene function defects.
Vachiranee Limviphuvadh. Biomolecular Function
Discovery Division, Bioinformatics Institute,
A*STAR, Singapore, Singapore
3486 — 12:00 Revisiting the Mendelian
disease paradigm: Lessons from next-generation
sequencing for retinal and macular degenerative
diseases. Anand Swaroop. National Eye Institute,
Bethesda, MD
3487 — 12:14 Knowledge Base for sensory
systems for biologists and clinicians. Thierry D.
Leveillard. Institut De La Vision, Paris, France;
Genetics, UPMC-UMRS 968, Paris, France
3488 — 12:28 Genetic signatures of rod and
cone-dominant retinas and mouse models of
retina degeneration. Krzysztof Palczewski. Case
Western Reserve Univ, Cleveland, OH
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
241
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3481 — 12:30 ROCK Inhibitor HA1077:
Potently Inhibits Corneal Fibrosis and
Neovascularization. Michael K. Fink1, 5, S.
Gupta1, 3, S. Ebers1, 4, E. Crider1, 4, M. Possin1, 4, E.
A. Giuliano1, 3, P. R. Sinha1, 3, F. G. Rieger1, 4, R.
R. Mohan1, 2. 1Harry S. Truman Veterans Hospital,
Columbia, MO; 2Veterinary Medicine & Surgery,
Biomedical Sciences, Veterinary Pathology, and
Mason Eye Institute, University of Missouri,
Columbia, MO; 3Veterinary Medicine & Surgery,
University of Missouri, Columbia, MO; 4Mason Eye
Institute, University of Missouri, Columbia, MO;
5
Veterinary Medicine & Surgery and Veterinary
Pathology, University of Missouri, Columbia, MO
Room Tahoma 4, TCC
3489 – 3507 – Tuesday – Posters
Exhibit/Poster Hall A0092-A0142
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Cornea / Retinal Cell Biology
338 Corneal Neovascularization and
Conjunctival Cell Biology and Surgery
Moderators: Choun-Ki Joo and Pedram Hamrah
3489 — A0092 The Effect of Mitomycin C in
Recurrent Pterygium Surgery with Amniotic
Membrane Transplantation. Byung Yi Ko, K. Han.
Ophthalmology, Konyang University College of
Medicine and Hospital, Daejeon, Korea
(the Republic of)
3490 — A0093 Validity of a new comprehensive
pterygia grading scale for use in clinical research
and clinical trial. Olivia L. Lee1, 2, P. Huang1, 2,
J. Huang1, 2, T. Tepelus1, 2, S. R. Sadda1, 2. 1Doheny
Image Reading Center, Doheny Eye Institute,
Pasadena, CA; 2Doheny Eye Institute, UCLA,
Los Angeles, CA *CR
Tuesday Posters
11:00 am – 12:45 pm
3491 — A0094 Incidence and Clinical
Characteristics of Stocker’s Line in Patients
with Pterygium. Hiroto Obata, Y. Arai, S. Makino.
Ophthalmology, Jichi Medical University, Tochigi,
Japan
3492 — A0095 Risk Factors for Recurrence
after Pterygium Surgery: An Image Analysis
Study. Sang Beom Han1, 2, J. Hwang2, J. Hyon2,
S. Lee1, J. Choi3. 1Ophthalmology, Kangwon
National University Hospital, Chuncheon, Korea
(the Republic of); 2Ophthalmology, Seoul National
University Bundang Hospital, Seongnam, Korea
(the Republic of); 3Saevit Eye Hospital, Goyang,
Korea (the Republic of)
3493 — A0096 Pterygium surgery: a
simplified approach to optimal cosmesis
and low recurrence. Rachel Shah, P. Channa.
Ophthalmology, Montefiore Medical Center/Albert
Einstein College of Medicine, Bronx, NY
3494 — A0097 Pterygium Surgery with
Mitomycin C in a HispanoAmerican Population
in Oaxaca, Mexico. Lucia Mendoza1, W. Teofilo1,
C. Arriaga1, S. I. Sayegh2. 1Clinica Narmi, Oaxaca,
Mexico; 2The EYE Center, Champaign, IL
3495 — A0098 Standardized strategy and longterm surgical outcomes in primary and recurrent
pterygium. Seika Den, Y. Satake, N. Nakayama, T.
Yamaguchi, J. Shimazaki. Ophthalmology, Tokyo
Dental College Hospital, Chiba, Japan
3496 — A0099 Supra-Tenon’s Excision of
Pterygium with 0.1ml Adjunctive Bevacizumab
(STEP 0.1): A Novel Recurrence-Free Technique
of Pterygium Surgery. Sayan Basu1, 3, R. Goyal1,
A. Hoshing1, D. K. Mishra2, V. Dave3. 1Cornea
and Anterior Segment, L V Prasad Eye Institute,
Hyderabad, India; 2Ocular Pathology Laboratory, L
V Prasad Eye Institute, Hyderabad, India; 3Center
for Ocular Regeneration, L V Prasad Eye Institute,
Hyderabad, India
3497 — A0100 TITLE: Excision,
Cryotherapy, and Postoperative Mitomycin
C for the Treatment of Conjunctival-corneal
Intraepithelial Neoplasia. Luana Campos, L.
Pinheiro Teixeira, M. Martins Abrahao, B. A.
Nassaralla, A. Nassaralla. Nuffield Dept of Clinical
Neurosciences, Instituto de Olhos de Goiania,
Goiania, Brazil *CR
3498 — A0101 Upper and Lower Conjunctival
Fornix Depth in Healthy Caucasian Eyes: A
Method of Objective Assessment. Valerie Saw1, 2,
D. Carpenter3, S. Hau1, D. Booth1, H. Jasim1, E.
Tay1, C. Daniel1, G. Jutley1. 1Cornea & External
Disease, Moorfields Eye Hospital, London, United
Kingdom; 2UCL Institute of Ophthalmology,
London, United Kingdom; 3Ocular Prosthetics
Department, Moorfields Eye Hospital, London,
United Kingdom
3499 — A0102 Giant Conjunctival CystsClinical Features of 13 Cases. Mamta V. Shah1, N.
Farber1, C. L. Shields2, J. A. Shields2, M. Dweck3,
O. Gorenburg4, E. Wladis5, T. Nakra6, R. Allen7,
R. Shinder1.1Ophthalmology, SUNY Downstate
Medical Center, Albertson, NY; 2Ocular Oncology,
Wills Eye Hospital, Thomas Jefferson University,
Philadelphia, PA; 3Mount Sinai Doctors Brooklyn
Heights, Brooklyn, NY; 4Clear View Medical
P.C., Brooklyn, NY; 5Ophthalmology, Lions Eye
Institute, Albany Medical College, Albany, NY;
6
Texas Oculoplastic Consultants, Austin, TX;
7
Ophthalmology, University of Iowa, Iowa City, IA
3500 — A0103 A clinical survey on
subcutaneous triamcinolone acetonide eyelid
injection for vernal keratoconjunctivitis. Tomoko
Kawamura-Tsukahara, Y. SAEKI, J. Huang, E.
Uchio. ophthalmology, Fukuoka University,
Fukuoka, Japan
3501 — A0104 The withdrawal rate
of oral and topical corticosteroids in
vernal keratoconjunctivitis after topical
immunosuppresants. Mika Shinoda, Y. Saeki,
J. Huang, T. Tsukahara, E. Uchio. Fukuoka
University, Fukuoka, Japan
3502 — A0105 Valproic acid promotes
inflammation in conjunctival wound healing.
Li-Fong Seet1, 2, L. Toh1, T. T. Wong1, 2. 1Ocular
Therapeutics & Drug Delivery, Singapore Eye
Research Institute, Singapore, Singapore; 2Research,
Duke-NUS Medical School Singapore, Singapore,
Singapore
3503 — A0106 Reducing Adenoviral Patient
Infected Days (RAPID) Planning Study:
Agreement between Clinician and AdenoPlusTM
in the Diagnosis of Adenoviral Conjunctivitis.
Mary Migneco1, M. O. Gordon1, A. T. Hartwick6,
S. Johnson2, J. Harthan3, C. Morettin3, T. Than4, E.
Shorter5, J. Huecker1. 1Ophthalmology, Washington
University in St. Louis, St. Louis, MO; 2Optometry,
Northeastern State University, Tahlequah, OK;
3
Optometry, Illinois College of Optometry,
Chicago, IL; 4Optometry, University of Alabama,
Birmingham, Birmingham, AL; 5Ophthalmology,
Illinois Eye and Ear Infirmary, Chicago, IL;
6
Optometry, Ohio State University, Columbus, OH f
3504 — A0107 The Effect of Preserved Antiglaucoma Eye-drops on Goblet Cells and the
Expression of Pro-inflammatory Markers.
Javier Moreno-Montanes1, 3, G. Carracedo2, 3, E.
Carnero1, 3, A. Bleau1, B. Fonseca2, 3, A. MartínezÁguila2, 3, J. J. Pintor2, 3, A. Guarnieri1, 3. 1Dep. of
Ophthalmology, University of Navarra, Pamplona,
Spain; 2Dep. of Biochemistry and Molecular
Biology IV (Faculty of Optic and Optometry),
University Complutense, Madrid, Spain;
3
OFTARED, RETICS Patología Ocular, Instituto
Carlos III, Madrid, Spain *CR
3505 — A0108 Novel Characterization of
Resident Plasmacytoid Dendritic Cells in the
Conjunctiva. Aakash Gupta1, A. Jamali1, 2, M. J.
Lopez1, 2, V. Sendra1, 2, D. L. Harris1, 2, H. Moein1, 2,
Y. Seyed-Razavi1, 2, P. Hamrah2, 3. 1Ophthalmology,
Tufts Medical Center, Tufts University School of
Medicine, Boston, MA; 2Ophthalmology, Schepens
Eye Research Institute/Massachusetts Eye and
Ear, Harvard Medical School, Boston, MA;
3
Ophthalmology, Cornea Service, New England
Eye Center, Tufts Medical Center, Tufts University
School of Medicine, Boston, MA
3506 — A0109 Immune Responses Induced
by chlamydial Polymorphic Membrane Protein
C formulated with probiotic Lactobacillus
rhamnosus as an Adjuvant in Conjunctival
Immunization. Aleksandra Inic-Kanada1, M.
Stojanovic2, E. Marinkovic2, E. Stein1, I. Lukic2, S.
Belij1, N. Schuerer1, J. Montanaro1, E. Ghasemian1,
R. Djokic2, T. Barisani-Asenbauer1. 1OCUVAC
- Laura Bassi, Center for Pathophysiology,
Infectiology and Immunology, Medical University
of Vienna, Vienna, Austria; 2Department of
Research and Development, Institute of Virology,
Vaccines and Sera - TORLAK, Belgrade, Serbia
3507 — A0110 Rebamipide enhances the
barrier function of human conjunctival
epithelium. Yoshiyuki Satake, K. Higa, M. Dogru,
T. Yamaguchi, J. Shimazaki. Ophthalmology, Tokyo
Dental College, Ichikawa, Japan *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
242
Tuesday – Posters – 3508 – 3530
3508 — A0111 Time course of oxidative stress
markers and inflammatory mediators in human
conjunctival epithelial cells exposed to diesel
exhaust particles. Romina M. Lasagni Vitar1, J.
Tau2, A. Tesone2, N. Janezic1, A. Hvozda Arana1,
C. Reides1, A. Berra2, S. M. Ferreira1, S. Llesuy1.
1
General and Inorganic Chemistry Division,
IBIMOL (UBA-CONICET), Faculty of Pharmacy
and Biochemistry, University of Buenos Aires,
Buenos Aires, Argentina; 2Ocular Investigation
Laboratory, Pathology Department, Faculty of
Medicine, University of Buenos Aires, Buenos
Aires, Argentina
3517 — A0120 Topical Low-Molecular-Weight
Heparin-Taurocholate 7 Inhibits Corneal
Neovascularization. Jae Yong Kim, M. Cheon, E.
Kim, M. Kim, H. Tchah. Ophthalmology, University
of Ulsan College of Medicine, Asan Medical
Center, Seoul, Korea (the Republic of)
3509 — A0112 Oxidative stress measures in
human tears and associations with conjunctival
ultraviolet autofluorescence. Kristina Haworth1,
H. L. Chandler2. 1Southern College of Optometry,
Memphis, TN;2The Ohio State University College
of Optometry, Columbus, OH
3519 — A0122 Blockade with Anti- Epithelial
Membrane Protein-2 Antibody Decreases VEGF
Expression in Human Corneal Limbal Epithelial
Cells. Ann M. Chan, M. Wadehra, L. K. Gordon.
University of California, Los Angeles, Los Angeles,
CA *CR
3510 — A0113 Naringenin inhibits corneal
neovascularization by anti-inflammatory and
anti-oxidant mechanisms. Ana T. Oguido, A. M.
Casella, W. Verri Junior, M. Hohmann, F. Ribeiro.
Ophyhalmology, Univeridade Estadual de Londrina,
Londrina, Brazil
3520 — A0123 PI3K/Akt/mTOR - A new
target for corneal angiogenesis treatment?
Javier A. Calles1, T. Sasore2, A. Lopez-Garcia1,
B. N. Kennedy2, Y. Diebold1. 1IOBA - University
of Valladolid, Valladolid, Spain; 2UCD SBBS &
Conway Institute - University College Dublin,
Dublin, Ireland
3512 — A0115 Potential modulatory role
for MMP14 cleavage of VEGFR1 during
angiogenesis. Kyuyeon Han, J. Chang, D. T. Azar.
Ophthalmology and Visual Sciences, University of
Illinois at Chicago, Brookfield, IL
3513 — A0116 miR-184 directly regulates
corneal angiogenesis. Jong Kook, H. Peng, W.
Yang, O. Volpert, R. M. Lavker. Feinberg School of
Medicine, Northwestern University, Chicago, IL
3514 — A0117 Antiangiogenic Effect of a Novel
Fusion Protein PFMC inhibiting NFKB pathway
on Corneal Alkali Injury Rat Model. Juan P.
Salica1, 2, A. Fichetti2, E. Chuluyan3, D. Guerrieri3,
J. E. Gallo1, 2. 1Ophthalmology, Universidad
Austral, Pilar, Argentina; 2Nanomedicine and
Vision Group, Universidad Austral, ilarP, Argentina;
3
Pharmacology Department, Universidad de Buenos
Aires, Capital Federal, Argentina
3515 — A0118 Anti-inflammatory and antifibrotic effects of novel peptide GQDGLAGPK
in alkaline burns rabbit. Lee Yoon Jin, H. Lee, Y.
Lee, J. Yang. Inje university Busan paik hospital,
Busan, Korea (the Republic of)
3516 — A0119 Anti-Angiogenic Polymer
Therapeutic for Corneal Neovascularization.
Crystal Shin, X. Yuan, D. Marcano, L. Isenhart,
K. Simmons, S. C. Pflugfelder, G. Acharya.
Ophthalmology, Baylor College of Medicine,
Houston, TX
3521 — A0124 The Neuropeptide
Adrenomedullin as a New Target to Treat
Corneal Angiogenesis. Deshea L. Harris1, A.
Jamali1, A. Abbouda1, H. Moein1, P. Hamrah1, 2.
1
Ophthalmology, Tufts Medical Center, Boston,
MA; 2New England Eye Center, Boston, MA
3522 — A0125 Regression Of Corneal
Neovascularization Associated With Corneal
Epithelial Defect After Treatment With
Regenerating Agents ( Cacicol®). Olivia Esteban,
M. A. del Buey, I. Perez, C. Almenara, M. Martinez,
J. A. Cristóbal. Ophthalmolgy, Hospital,
Zaragoza, Spain
3523 — A0126 Induced capillary remodelling
in inflammatory ocular angiogenesis model.
Anthony Mukwaya1, B. Bourghardt Peebo1, M.
Xeroudaki1, Z. Ali2, L. Jensen2, 3, N. S. Lagali1.
1
Ophthalmology, Linkoping University, Linköping,
Sweden; 2Department of Medical and Health
Sciences, Division of Cardiovascular Medicine,
Linköping University, Linkoping, Sweden;
3
Department of Microbiology, Tumor and Cell
biology, the Karolinska Institute, Stockholm,
Sweden *CR
3524 — A0127 Mechanistic studies for Vascular
Endothelial Growth Factor-A and -B induced
neuronal and endothelial cell growth. Victor
H. Guaiquil, Y. Luo, J. Sarkar, M. Rosenblatt.
Department of Ophthalmology and Visual Sciences,
University of Illinois-Chicago, Chicago, IL
3526 — A0129 Background Data in a
Rabbit Model of Suture-Induced Corneal
Neovascularization (CNV). Mark Vezina1, C. Li1,
M. Bussieres2. 1Ocular and Neuroscience, Charles
River, Senneville, QC, Canada; 2V & O Services,
St. Lazare, QC, Canada *CR
3527 — A0130 DELTA Scoring System: A
Novel method for clinical grading of corneal
neovascularization. SUNEEL Gupta1, 2, M. K.
Fink1, 4, P. R. Sinha1, 2, R. R. Mohan1, 3. 1Harry S.
Truman Memorial Veteran Hospital, Columbia,
MO; 2Veterinary Medicine & Surgery, University of
Missouri, Columbia, MO; 3Veterinary Medicine &
Surgery, Biomedical Sciences, Veterinary Pathology
and Mason Eye Institute, University of Missouri,
Columbia, MO; 4Veterinary Medicine & Surgery
and Veterinary Pathology, University of Missouri,
Columbia, MO
3528 — A0131 Pro-angiogenic Factors are
Elevated in the Cornea of Patients undergoing
Transplant for Conditions Associated with
Infection Compared to Non-infectious or
Inflammation Alone. Jennifer L. Wu1, J. K.
Jinkins1, D. J. Carr1, 2. 1Ophthalmology, Dean
McGee Eye Institute, Oklahoma City, OK;
2
Ophthalmology, University of Oklahoma Health
Sciences Center, Oklahoma City, OK
3529 — A0132 Macrophages, angiopoietin 2,
and corneal neovascularization: translational
implications. Giulio Ferrari1, C. giacomini1, F.
Bignami1, D. moi1, A. ranghetti1, C. doglioni1, L.
naldini1, P. Rama1, R. mazzieri2. 1San Raffaele
Scientific Institute, Milan, Italy; 2Diamantina
Institute Faculty of Medicine and Biomedical
Sciences, The University of Queensland, Brisbane,
QLD, Australia
3530 — A0133 Comparison of Two Treatments
for Corneal Neovascularization One-Year
Follow-Up: Photodynamic therapy with
Verteporfin vs Photodynamic Therapy combined
with Subconjunctival Ranibizumab. Alexandra
Pena1, A. Navas2, E. O. Graue-Hernandez2, G.
de Wit3, R. Bolanos3, 1. 1Ophthalmology, Regional
Hospital Lic. Adolfo Lopez Mateos Issste, Mexico
City, Mexico;2Cataract and refractive surgery,
Institute of Ophthalmology Conde de Valenciana,
Mexico, Mexico; 3Cornea and refractive surgery,
Association to prevent blindness in Mexico,
Mexico, Mexico
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
243
Tuesday Posters
11:00 am – 12:45 pm
3511 — A0114 MMP12 Inhibits Corneal
Neovascularization Through Regulation of
CCL2. Matilda F. Chan, M. Wolf, S. M. Clay.
Ophthalmology, Univ of California-San Francisco,
San Francisco, CA
3518 — A0121 Topical Fosaprepitant
Treatment in Established Corneal
Neovascularization. Fabio Bignami, A. Lorusso,
P. Rama, G. Ferrari. Cornea and Ocular Surface
Disease Unit, Eye Repair Lab, IRCCS San Raffaele
Scientific Institute, Milan, Italy *CR
3525 — A0128 Relation of Tenascin X and
VEGF in the corneal cauterization model.
Takayoshi Sumioka1, Y. Okada1, O. Yamanaka1,
Y. Nidegawa1, M. Miyajima2, K. Matsumoto3,
S. Saika1. 1Ophthalmology, Wakayama Medical
University, Wakayama, Japan; 2Animal center,
Wakayama Medical University, Wakayama, Japan;
3
Interdisciplinary Center for Science Research,
Department of Biosignaling and Radioisotope
Experiment, Shimane University, Shimane, Japan
3531 – 3551 – Tuesday – Posters
3531 — A0134 Effects of Vascular Endothelial
Growth Factor-A and -B on angiogenesis and
nerve regeneration of the cornea. qiang zhou,
V. H. Guaiquil, Y. Luo, M. Sun, M. Rosenblatt.
Ophthalmology & Visual Science, University of
Illinois at Chicago, Chicago, IL
3532 — A0135 Angiopoietin-like 3 (ANGPTL3)
Does not Induce Corneal Neovascularization
(CoNV) after Intrastromal Injection of Plasmid
DNA Encoding ANGPTL3 in Mice. Duo Sun, H.
Li, Y. Liu, P. Stevis, V. Gusarova, C. Romano, J.
Cao. Regeneron Pharmaceuticals, Inc., Tarrytown,
NY *CR
Tuesday Posters
11:00 am – 12:45 pm
3533 — A0136 Maspin regulates human lymph
endothelial cell tube formation in a biphasic
manner. Sally S. Twining, D. Warejcka, X. Moua.
Biochemistry and Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI
3539 — A0142 Comparison of Surgical
Methods and the Use of Mitomycin-C for the
Treatment of Recurrent Pterygium. Hyunjoo J.
Lee, Y. J. Kim. Ophthalmology, Boston University
School of Medicine, Boston, MA
3545 — A0243 Decreased Intraocular Pressure
after Tarsal Strip for Ectropion Repair. Chad
Kaplan, T. Nees, L. Ghadiali, D. Blumberg, L. AlAswad, G. A. Cioffi, C. De Moraes, B. Winn, J. M.
Liebmann. Ophthalmology, Columbia University,
New York, NY
Exhibit/Poster Hall A0238-A0271
3546 — A0244 Change in biomechanical
parameters analyzed with the Corvis ST
following trabeculectomy. Karin R. Pillunat, E.
Spoerl, L. E. Pillunat. Ophthalmology, Univ Clinic
Carl Gustav Carus Dresden, Dresden, Germany f
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Glaucoma
339 Glaucoma Biomechanics
Moderators: Massimo A. Fazio and Rafael Grytz
3534 — A0137 VEGF-C trap to block
lymphangiogenesis after corneal transplantation.
Susie Choi. Ophthalmology, University of Utah,
Salt Lake City, UT
3540 — A0238 Aqueous Humor Flow in the
Posterior Chamber of the Eye in the Case of
Iridotomy. Jennifer H. Tweedy1, M. Dvoriashyna2,
R. Repetto2. 1Department of Bioengineering,
Imperial College London, London, United
Kingdom; 2Department of Civil, Chemical and
Environmental Engineering, University of Genoa,
Genoa, Italy *CR
3535 — A0138 Overexpression of
monocyte-derived Wnt5a promotes corneal
lymphangiogenesis. Roberto Sessa1, P.
Padmanaban1, S. Wan1, S. Shen1, A. Smith3, T.
Yamaguchi2, R. A. Lang3, L. Chen1.1Optometry,
UC Berkeley, Berkekely, CA; 2Center for Cancer
Research, National Institutes of Health, Frederick,
MD; 3Visual Systems Group, Cincinnati Children’s
Hospital Medical Center, Cincinnati, OH
3541 — A0239 Regionally Discrete Aqueous
Humor Outflow Quantification using Fluorescein
Canalograms. Eric N. Brown1, R. Loewen2, 3, P.
Sengupta2, 3, J. S. Schuman2, 3, I. A. Sigal2, 3, N.
A. Loewen2, 3.1Department of Ophthalmology,
Vanderbilt University, Nashville, TN; 2Department
of Ophthalmology, University of Pittsburgh,
Pittsburgh, PA; 3The Louis J Fox Center for Vision
Restoration, University of Pittsburgh, Pittsburgh, PA
3536 — A0139 RNA sequencing-based
comparative transcriptome analysis of nasaltemporal difference of corneal lymphangiogenesis.
guangyu li1, 2, Y. Wen1, 2, L. zhang1, 2, L. Chen1, 2.
1
Vision Science Graduate Group, University of
California, Berkeley, Berkeley, CA; 2Center for
Eye Disease and Development, Program in Vision
Science and School of Optometry, University of
California, Berkeley, CA
3542 — A0240 Treatment with AICAR
decreases intraocular pressure in perfused ex
vivo human anterior segments. Ayan Chatterjee1,
G. Villarreal3, D. Oh2, D. J. Rhee2. 1Wills Eye
Hospital, Philadelphia, PA; 2Department of
Ophthalmology and Visual Sciences, Case Western
Reserve University, Cleveland, OH; 3Wilmer Eye
Institute, Baltimore, MD *CR
3537 — A0140 Specific Inhibition of
Inflammatory Corneal Lymphangiogenesis by
Topical Inhibition of VEGF-C and -D. Felix
Bock1, A. Schneider1, M. Baldwin2, C. Cursiefen1.
1
Ophthalmology, University of Cologne, Cologne,
Germany; 2Opthea Pty Ltd/ Circadian Technologies
Limited, South Yarra, VIC, Australia *CR
3538 — A0141 Tracking Changes in Corneal
Tomography After Pterygium Excision to
Aid Planning Future Refractive Surgery.
Michael Korchak1, S. L. Cremers2, J. Ha2, J.
Koppinger1, 3, J. A. Martinez2, 1. 1Ophthalmology,
Medstar Georgetown/Washington Hospital Center,
Washington, DC; 2Visionary Ophthalmology,
Rockville, MD; 3Georgetown University School of
Medicine, Washington, DC
3543 — A0241 Estimating human trabecular
meshwork stiffness by numerical modeling
and advanced OCT imaging. Ke Wang1,
M. A. Johnstone2, C. Xin3, S. Padilla2, R. K.
Wang3, C. R. Ethier1.1Biomedical Engineering,
Georgia Institute of Technology, Atlanta, GA;
2
Ophthalmology, University of Washington, Seattle,
WA; 3Bioengineering, University of Washington,
Seattle, WA
3544 — A0242 Bidirectional interactions
between trabecular meshwork cells and
their extracellular matrix in the presence of
dexamethasone. Vijaykrishna Raghunathan2, C.
J. Murphy1, 2, P. Russell2.1Ophthalmology & Vision
Science, University of California Davis, Davis, CA;
2
Surgical & Radiological Sciences, University of
California Davis, Davis, CA
3547 — A0245 Assessment of residual effects
due to topical medication on corneal stiffness in
primary open angle glaucoma. Sushma Tejwani1,
M. Francis2, S. Dinakaran1, R. Mehta1, R. shetty2,
A. Sinha Roy2. 1Glaucoma, Narayana Nethralaya,
Bangalore, India; 2Narayana Nethralaya, Bangalore,
India *CR
3548 — A0246 Estimating diurnal changes
in ocular dimension fluctuations using the
Triggerfish Contact Lens Sensor and assessing
its potential in 24-hour monitoring of heart
rate variability in glaucoma patients. Monika
E. Danielewska1, M. Rekas2, A. Byszewska2, J.
Wierzbowska2, K. Petz2, D. Iskander1. 1Department
of Biomedical Engineering, Wroclaw University
of Technology, Wroclaw, Poland; 2Department of
Ophthalmology, Military Institute of Medicine,
Warsaw, Poland
3549 — A0247 Corneal Peak Distance (PD)
is Higher in Primary Angle Closure Glaucoma
(PACG) Subjects than in Normal and Primary
Open Angle Glaucoma (POAG) Subjects. Owen
Png1, M. Baskaran2, 3, T. Tun2, S. Sharma2, Y. Tham2,
C. Cheng2, 3, T. Aung2, 3, M. J. Girard4. 1Duke-NUS
Graduate Medical School, Singapore, Singapore;
2
Singapore Eye Research Institute, Singapore,
Singapore; 3Singapore National Eye Centre,
Singapore, Singapore; 4National University of
Singapore, Singapore, Singapore
3550 — A0248 Correlating corneal
biomechanical properties with lamina cribosa in
healthy subjects. Francisco Pérez Bartolomé, J.
Martínez de la Casa, I. Camacho Bosca, F. Sáenz
Francés, J. García Feijoó. Ophthalmology, Hospital
Clínico San Carlos, Madrid, Spain
3551 — A0249 Ocular rigidity: a novel noninvasive clinical method. Diane N. Sayah2, 1,
J. Mazzaferri2, L. Beaton2, F. Lalonde2, 3, M.
Hidalgo2, 4, S. Costantino2, 5, M. R. Lesk2, 5. 1School
of Optometry, University of Montreal, Roxboro,
QC, Canada; 2Ophthalmology, MaisonneuveRosemont Hospital Research Center, Montreal,
QC, Canada; 3Biomedical Sciences, University of
Montreal, Montreal, QC, Canada; 4Institut National
de la Recherche Scientifique, Varennes, QC,
Canada; 5Ophthalmology, University of Montreal,
Montreal, QC, Canada *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
244
Tuesday – Posters – 3552 – 3571
3552 — A0250 The Relationships between
Corneal Elasticity Measured by Surface Wave
Elastography and other Ocular Variables. Arash
Kazemi1, J. W. McLaren1, C. M. Pruet1, S. Lin2, 1,
X. Zhang1, A. J. Sit1. 1Ophthalmology, Mayo Clinic
Rochester, Rochester, MN; 2Ophthalmology, Wills
Eye Hospital, Philadelphia, PA
3553 — A0251 Relationships between Axial
Length and Ocular Biomechanical Properties.
Christopher M. Pruet, A. Kazemi, X. Zhang, J. W.
McLaren, A. J. Sit. Ophthalmology, Mayo Clinic,
Rochester, MN*CR
3554 — A0252 Progression in infantile
glaucoma: comparing structural and biometric
changes. Kara M. Cavuoto, K. Jaben, T. C. Chang.
Univ of Miami Sch of Medicine, Miami, FL
3556 — A0254 Shape Changes of the Anterior
Lamina Cribrosa in Healthy and Glaucoma Eyes
following Acute Intraocular Pressure Elevations.
Tin A. Tun1, O. Png2, B. Mani1, 2, S. Sharma1,
H. M. Htoon1, 2, S. Thakku1, C. Cheng1, 2, N. G.
Strouthidis3, 1, T. Aung1, 2, M. J. Girard1. 1Singapore
Eye Research Institute, Singapore, Singapore;
2
Duke-NUS Graduate Medical School, Singapore,
Singapore; 3NIHR Biomedical Research Centre,
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology, London,
United Kingdom
3557 — A0255 A Novel Virtual Fields Method
to Measure the Biomechanical Properties
of Human Optic Nerve Head Tissues.
Liang Zhang1, 2, M. Baskaran3, 4, T. Aung3, 5, N.
Strouthidis3, 6, M. J. Girard2, 3. 1NUS Graduate
School for Integrative Sciences and Engineering,
National University of Singapore, Singapore,
Singapore; 2Ophthalmic Engineering & Innovation
Laboratory, Department of Biomedical Engineering,
National University of Singapore, Singapore,
Singapore; 3Singapore Eye Research Institute,
Singapore National Eye Centre, Singapore,
Singapore; 4Eye-ACP, Office of Clinical, Academic
and Faculty Affairs, Duke-NUS Medical School,
Singapore, Singapore; 5Yong Loo Lin School
of Medicine, National University of Singapore,
Singapore, Singapore; 6NIHR Biomedical Research
Centre, Moorfields Eye Hospital NHS Foundation
Trust and UCL Institute of Ophthalmology, London,
United Kingdom
3559 — A0257 Finite element analysis of
pressure effect on biomechanical response of
the optic nerve head in glaucoma. Yingyan Mao.
Beijing Tongren Eye Center, Beijing Institute of
Ophthalmology, Beijing, China
3560 — A0258 Probabilistic Modeling of
Intracranial Pressure Effects on Optic Nerve
Biomechanics. C R. Ethier1, A. J. Feola1, J.
Raykin1, J. G. Myers2, E. S. Nelson2, B. C. Samuels3.
1
Biomedical Engineering, Georgia Institute of
Technology, Atlanta, GA; 2NASA Glenn Research
Center, Cleveland, OH; 3Ophthalmology, UAB,
Birmingham, AL
3561 — A0259 In vivo evaluation of optic
disc changes and anterior lamina cribrosa
displacement after acute cerebrospinal fluid
pressure reduction in healthy humans. Muriel
Poli1, 3, A. M. Bron4, E. Sellem2, P. Denis3, C.
Burillon3. 1Centre Ophtalmologique Pole Vision Val
d’Ouest, Lyon, Dominica; 2Centre Ophtalmologique
Kleber, Lyon, France; 3Centre Hospitalier
Universitaire, Lyon, France; 4Centre Hospitalier
Universitaire, Dijon, France
3562 — A0260 Asymmetry in anterior lamina
cribrosa surface tilting may contribute to retinal
nerve fiber layer defect in myopia. Eun Jung Lee,
J. Han, C. Kee. Ophthalmology, Samsung Medical
Center, Sungkyunkwan university, Seoul, Korea
(the Republic of)
3563 — A0261 Optic Nerve (ON) Sheath
Traction on the Temporal Peripapillary Sclera in
Adduction: Biomechanical Evidence for a Role
in Normal Tension Glaucoma (NTG). Andrew
Shin, J. Park, J. L. Demer. Ophthalmology, Stein
Eye Institute, UCLA, Los Angeles, CA
3564 — A0262 Regional Variations in the
Strains of the Human Optic Nerve Head. Dan
Midgett2, T. D. Nguyen2, H. A. Quigley1, M. Pease1,
C. Franck3, M. Patel3. 1Ophthalmology, Johns
Hopkins, Baltimore, MD; 2Mechanical Engineering,
Johns Hopkins University, Baltimore, MD;
3
Engineering, Brown University, Providence, RI
3565 — A0263 In-vivo Modulation of
Intraocular and Intracranial Pressures Causes
Nonlinear and Non-monotonic Deformations
of The Lamina Cribrosa. Huong Tran1, 2, A. P.
Voorhees1, B. Wang1, 2, N. Jan1, 2, E. Tyler-Kabara3,
L. Kagemann1, 2, H. Ishikawa1, 2, J. S. Schuman1, 2,
M. A. Smith1, 2, G. Wollstein1, I. A. Sigal1, 2. 1UPMC
Eye Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh
School of Medicine, Pittsburgh, PA; 2Department
of Bioengineering, University of Pittsburgh,
Pittsburgh, PA; 3Department of Neurosurgery,
University of Pittsburgh, Pittsburgh, PA *CR
3566 — A0264 Novel method reveals
heterogeneous micro-scale response of sclera
collagen bundles to homogeneous macro-scale
stretch. Ning-Jiun Jan1, 2, M. Iasella2, M. Lester2,
D. Hu1, K. L. Lathrop1, A. P. Voorhees1, H. Tran1, 2,
G. Wollstein1, J. S. Schuman1, 2, I. A. Sigal1, 2.
1
Ophthalmology, University of Pittsburgh School of
Medicine, UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Pittsburgh, PA; 2Bioengineering, Swanson
School of Engineering, University of Pittsburgh,
Pittsburgh, PA *CR
3567 — A0265 Collagen crimp waviness,
tortuosity and period have different patterns
around the eye. Danielle Hu1, N. Jan1, 2, M.
Iasella1, 2, H. Tran1, 2, Y. Ling1, J. S. Schuman1, 2,
A. Judisch1, A. P. Voorhees1, G. Wollstein1, 2, I. A.
Sigal1, 2. 1Opthalmology, University of Pittsburgh,
Pittsburgh, PA; 2Bioengineering, University of
Pittsburgh, Pittsburgh, PA *CR
3568 — A0266 ONH Deformation in Porcine
Eyes Using Ultrasound Speckle Tracking. Elias
Pavlatos, X. Pan, R. T. Hart, P. Weber, J. Liu. The
Ohio State University, Columbus, OH
3569 — A0267 Polarization Sensitive Optical
Coherence Tomography (PSOCT) Demonstrates
Strain Dependent Birefringence in Ocular
Tissues. Joseph Park, A. Shin, J. L. Demer. Jules
Stein Eye Institute, University of California Los Angeles, Los Angeles, CA
3570 — A0268 Finite Element (FE) Modeling
of Optic Nerve Head (ONH) Biomechanics in a
Rat Model of Glaucoma. Stephen A. Schwaner1,
M. Pazos4, H. Yang2, C. F. Burgoyne2, C. R.
Ethier3, 1.1Mechanical Engineering, Georgia Institute
of Technology, Atlanta, GA; 2Ophthalmology,
Devers Eye Institute, Portland, OR; 3Biomedical
Engineering, Georgia Institute of Technology,
Atlanta, GA; 4Departamento del Luminotecnia,
Hospital Esperanza. Parc de Salut Mar.,
Barcelona, Spain
3571 — A0269 Effects of intracranial and
intraocular pressure modification on the optic
nerve of young and old rats. Da Zhao, C. T.
Nguyen, Z. He, A. J. Vingrys, B. V. Bui. Optometry
and Vision Sciences, University of Melbourne,
Melbourne, VIC, Australia
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
245
Tuesday Posters
11:00 am – 12:45 pm
3555 — A0253 Racioethnic Differences in the
Biomechanical Environment of the Lamina
Cribrosa. Jonathan P. Vande Geest1, 5, S. Ram3,
S. J. Howerton1, F. Danford1, U. Utzinger4, 5,
J. J. Rodriguez3, 2.1Aerospace and Mechanical
Engineering, The University of Arizona, Tucson,
AZ; 2Graduate Interdisciplinary Program of
Biomedical Engineering, The University of Arizona,
Tucson, AZ; 3Electrical and Computer Engineering,
The University of Arizona, Tucson, AZ; 4BIO5
Institute, The University of Arizona, Tucson,
AZ; 5Biomedical Engineering, The University of
Arizona, Tucson, AZ
3558 — A0256 Influence of tissue viscoelasticity
on the optic nerve head perfusion: a
mathematical model. Daniele Prada1, R. Sacco3,
B. Cockburn4, L. Bociu5, J. Webster6, B. A. Siesky2,
A. Harris2, G. Guidoboni1, 2. 1Mathematical
Sciences, Indiana University-Purdue University
Indianapolis, Indianapolis, IN; 2Ophthalmology,
Indiana University, Indianapolis, IN; 3Mathematics,
Politecnico di Milano, Milano, Italy; 4Mathematics,
University of Minnesota, Minneapolis, MN;
5
Mathematics, North Carolina State University,
Raleigh, NC; 6Mathematics, College of Charleston,
Charleston, SC *CR
3572 – 3589 – Tuesday – Posters
3572 — A0270 A Pilot Study for the Initial
Validation of a Tree Shrew Model of Glaucoma.
Brian C. Samuels, C. A. Girkin, L. Hethcox, J. C.
Downs, W. Zhan. Ophthalmology, University of
Alabama at Birmingham, Birmingham, AL
3573 — A0271 Generation of a viable, fertile
Matrix-Gla (Mgp)-floxed mouse by CRISPR/
CAS9 technology. Relevance for the creation
of stiffness mouse models of glaucoma. Terete
Borras1, 2, K. Pandya3, 4, D. Cowley3, R. Elliott1.
1
Ophthalmology, Universsity of North Carolina
at Chapel Hill, Chapel Hill, NC; 2Gene Therapy
Center, Chapel Hill, NC; 3University of North
Carolina at Chapel Hill, Chapel Hill, NC;
4
Transviragen, Raleigh, NC
Exhibit/Poster Hall B0014-B0027
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Visual Neuroscience / Low Vision
340 Ganglion Cells and Beyond
Tuesday Posters
11:00 am – 12:45 pm
Moderator: Michael B. Manookin
3574 — B0014 Morphological characteristics
of retinal ganglion cells in the giant panda
(Ailuropoda melanoleuca) retina. Wenyao Wang1,
C. Wang2, Y. Zhou1, R. Wei2, Y. Nan1, L. Deng2,
J. Gao1, C. Zhang3, D. Li2, M. Pu1. 1Anatomy/
Embryology, Peking University, Beijing, China;
2
China Conservation and Research Center for the
Giant Panda (CCRCGP), Chengdu, China; 3Peiking
University Third Hospital, Beijing, China
3575 — B0015 Morphological and
physiological diversity of retinal ganglion cells in
the vertebrate retina. Ji-Jie Pang, F. Gao, S. M.
Wu. Ophthalmology, Baylor College of Medicine,
Houston, TX
3576 — B0016 Properties of novel types of
transient On ganglion cells in the rabbit retina.
Ye Long, S. L. Mills. Univ of Texas Health Science
Center at Houston, Houston, TX
3577 — B0017 Electrical and Visual STA
Types Correlate in Mouse Retina. Sudarshan
Sekhar, A. Jalligampala, E. Zrenner, D. L. Rathbun.
Experimental Retinal Prosthetics Group, Institute
for Ophthalmic Research, University of Tuebingen,
Tuebingen, Germany *CR
3578 — B0018 In search of the color-coding
ganglion cell. Michael B. Manookin, J. A.
Kuchenbecker, M. Neitz, J. Neitz. Ophthalmology,
University of Washington, Seattle, WA
3579 — B0019 TRPV4 Augments The
Excitability Of Mouse Retinal Ganglion
Cells. Oleg Yarishkin1, M. B. Kozhemyakin1,
D. A. Ryskamp1, D. Krizaj1, 2. 1Department of
Ophthalmology and Visual Sciences, University
of Utah School of Medicine, John A. Moran Eye
Institute, Salt Lake City, UT; 2Department of
Neurobiology and Anatomy, University of Utah
School of Medicine, John A. Moran Eye Institute,
Salt Lake City, UT
3580 — B0020 Spatial extent of inputs to
primate ganglion cells in natural viewing
conditions. Nora Brackbill1, N. Shah2, G. A. Goetz3,
A. Tikidji-Hamburyan3, C. Rhoades4, A. Sher5,
A. Litke5, E. Chichilnisky3. 1Physics, Stanford
University, Stanford, CA; 2Electrical Engineering,
Stanford University, Stanford, CA; 3Neurosurgery,
Ophthalmology, and Hansen Experimental Physics
Laboratory, Stanford University, Stanford, CA;
4
Bioengineering, Stanford University, Stanford, CA;
5
Santa Cruz Institute for Particle Physics, University
of California, Santa Cruz, Santa Cruz, CA
3581 — B0021 Comparing receptive field
center size with dendritic field size of ganglion
cells in salamander retinas. Jing Wang, R. L.
Seilheimer, J. Sabharwal, S. M. Wu. Ophthalmology,
Baylor College of Medicine, Houston, TX
3582 — B0022 Determining the contribution of
specific retinal circuits to mouse retinal ganglion
cell space-time tuning. Jasdeep Sabharwal1, 2,
R. L. Seilheimer1, 2, J. Wang1, C. S. Cowan3, S. M.
Wu1.1Ophthalmology, Baylor College of Medicine,
Houston, TX; 2MSTP, Baylor College of Medicine,
Houston, TX; 3Neurobiology, Friedrich Miescher
Institute for biomedical research, Basel, Sweden
3583 — B0023 Sodium channel band
expression in the AIS: fundamentals of activation
threshold. Alex E. Hadjinicolaou2, 1, P. Werginz3, V.
Raghuram2, 1, F. Rattay3, S. I. Fried2, 1. 1Department
of Neurosurgery, Harvard Medical School, Boston,
MA; 2Vision Research Laboratory, Boston VA
Medical Center, Boston, MA; 3Institute for Analysis
and Scientific Computing, Vienna University of
Technology, Vienna, Austria
3584 — B0024 Antipsychotic drugs improve
visual responses of ganglion cells in a rat model
of retinitis pigmentosa. Ralph Jensen. VA Boston
Healthcare System, Boston, MA
3585 — B0025 Effect of brain state on visual
stimulus detectability in lateral geniculate
nucleus of anaesthetized marmosets. Paul R.
Martin1, 2, A. N. Pietersen1, 2, N. Zeater1, 2, S. K.
Cheong3, S. G. Solomon4, 5. 1Save Sight Institute,
University of Sydney, Sydney, NSW, Australia;
2
Australian Research Council Centre of Excellence
for Integrative Brain Function, Sydney, NSW,
Australia; 3Center for Visual Science, University
of Rochester, Rochester, NY; 4School of Medical
Sciences, University of Sydney, Sydney, NSW,
Australia; 5Experimental Psychology, University
College London, London, United Kingdom
3586 — B0026 Selective vulnerability of
specific retinal ganglion cell subtypes in a mouse
model of ocular hypertension. Yvonne Ou1, R.
Jo1, E. M. Ullian1, R. O. Wong2, L. Della Santina3.
1
Department of Ophthalmology, University of
California, San Francisco, San Francisco, CA;
2
Department of Biological Structure, University
of Washington, Seattle, WA; 3Department of
Pharmacy, University of Pisa, Pisa, Italy
3587 — B0027 Large scale matching of anatomy
and function of retinal ganglion cells. Filippo
Pisano1, E. Zampaglione2, N. McAlinden1, J.
Roebber2, M. D. Dawson1, K. Mathieson1, A. Sher2.
1
Dept.of Physics-University of Strathclyde, Institute
of Photonics, Glasgow, United Kingdom; 2Santa
Cruz Institute for Particle Physics, University of
California Santa Cruz, Santa Cruz, CA
Exhibit/Poster Hall B0028-B0045
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Visual Neuroscience
341 Clinical electrophysiology
Moderator: Jan J. Kremers
3588 — B0028 Effect of varying skin surface
electrode position on electroretinogram
responses recorded using a handheld stimulating
and recording system. Angharad E. Hobby1, 2,
D. Kozareva2, 3, E. H. Yonova2, 3, I. T. Hossain2, M.
Katta2, B. Huntjens1, A. Binns1, C. J. Hammond2, 3,
O. A. Mahroo2, 4. 1Division of Optometry & Visual
Sciences, City University London, London, United
Kingdom; 2Department of Ophthalmology, King’s
College London, St Thomas’ Hospital Campus,
London, United Kingdom; 3Department of Twin
Research and Genetic Epidemiology, King’s
College London, St Thomas’ Hospital Campus,
London, United Kingdom; 4Moorfields Eye
Hospital, London, United Kingdom
3589 — B0029 The heritability of implicit times
of photopic flicker electroretinogram responses
recorded using a handheld recording system
with skin electrodes. Xining He1, 2, E. H. Yonova1, 4,
D. Kozareva1, 4, M. Katta1, C. J. Hammond1, 4, O. A.
Mahroo1, 3. 1Department of Ophthalmology, King’s
College London, St Thomas’ Hospital Campus,
London, United Kingdom; 2Moorfields Eye
Hospital, 162 City Road, London, United Kingdom;
3
Institute of Ophthalmology, University College of
London, London, United Kingdom; 4Department of
Twin Research and Genetic Epidemiology, King’s
College of London, St Thomas’ Hospital Campus,
London, United Kingdom
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
246
Tuesday – Posters – 3590 – 3610
3590 — B0030 Altering the amplitude of
photopic negative responses recorded using the
RETeval visual electrodiagnostic system for
patients with glaucoma. Muneyoshi Kaneko1,
S. Machida2, S. Sakamoto3, N. Satou3, D.
Kurosaka4. 1Ophthalmology, Morioka Municipal
Hospital, Morioka, Japan; 2Ophthalmology,
Dokkyo Medical University, Koshigaya, Japan;
3
Ophthalmology, Sakamoto Eye Clinic, Miyako,
Japan;4Ophthalmology, Iwate Medical University,
Morioka, Japan
3591 — B0031 Multifocal electroretinography
to evaluate retinal function in the setting of a
multicenter clinical trial. Silvia N. Simao. CORC,
AIBILI, Coimbra, Portugal f
3592 — B0032 Screening test characteristics
of a novel hand-held ERG device in detection of
referable diabetic retinopathy. Taras V. Litvin1, 2,
G. H. Bresnick1, 3, G. Y. Ozawa1, K. Kanai1, J. A.
Cuadros1, 3. 1School of Optometry, UC Berkeley,
Berkeley, CA; 2Vision Science Graduate Group, UC
Berkeley, Berkeley, CA; 3EyePACS, LLC,
San Jose, CA *CR
3594 — B0034 Towards rapid assessment of
retinal function in clinic: comparison of implicit
times of photopic flicker electroretinogram
responses recorded using a conventional and
a portable system in patients with Birdshot
chorioretinopathy. Omar A. Mahroo1, 2, A. E.
Hobby1, 3, E. H. Yonova1, D. Kozareva1, I. T.
Hossain1, M. Katta1, C. J. Hammond1, M. R.
Stanford1. 1King’s College London, London, United
Kingdom; 2UCL Institute of Ophthalmology,
London, United Kingdom; 3City University,
London, United Kingdom
3595 — B0035 Super-normal flicker ERG
amplitudes in eyes with non-ischemic CRVO.
Ryohei Miyata2, K. Kato2, Y. Matsui1, M. Kozawa2,
H. Matsubara2, M. Sugimoto2, M. Kondo2.
1
Ophthalmology, Okanami General Hospital, Iga,
Japan; 2Ophthalmology, Mie University Graduate
School of Medicine, Tsu, Japan *CR
3597 — B0037 Multifocal electroretinogram
responses in former preterms with and without
history of retinopathy of prematurity (ROP).
Pablo Altschwager1, 2, R. M. Hansen1, 2, A.
Moskowitz1, 2, J. Bush1, A. B. Fulton1, 2. 1Boston
Children’s Hospital, Boston, MA; 2Harvard Medical
School, Boston, MA
3598 — B0038 Repeated Flicker
electroretinograms recordings before and after
intravitreal ranibizumab injection in eyes with
central retinal vein occlusion. Shunsuke Yasuda,
S. Ueno, S. Kachi, T. Kominami, A. Nakanishi, C.
Piao, H. Terasaki. Ophthalmology, Nagoya Univ
Graduate Sch of Med, Nagoya, Japan
3599 — B0039 Intravitreal Bevacizumab
and Laser Treatment for Type 1 Retinopathy
of Prematurity (ROP): Electroretinographic
Responses to Full-Field Stimuli. Domenico
Lepore1, E. A. Swanson2, L. Orazi1, F. Molle1, A.
Baldascino1, J. D. Akula2, R. M. Hansen2, A. B.
Fulton2. 1Ophthalmology, Catholic University of the
Sacred Heart, Rome, Italy; 2Ophthalmology, Boston
Children’s Hospital, Boston, MA *CR, f
3600 — B0040 Multimodal investigation
on inherited retinal dystrophies: an objective
approach to describe disease presentation and
progression. Lucia Ziccardi1, D. Giannini1, G.
Lombardo2, 3, S. serrao1, M. Varano1, A. Bruson4, M.
Bertelli4, M. Lombardo1. 1Ophthalmology, IRCCS
“G.B. Bietti” Eye Foundation, Rome, Italy; 2Ist. per
i processi Chimico-FIsici CNR-IPCF, Consiglio
Nazionale delle Ricerche, Messina, Italy; 3Vision
Engineering Italy, srl, Rome, Italy; 4MAGI Human
Medical Genetics Institute, Rovereto, Italy *CR
3601 — B0041 Function of the visual pathway
in preterm children at school age. Hanna
M. Akerblom1, S. Andreasson2. 1Neurosience,
Ophthalmology, Uppsala University, Uppsala,
Sweden; 2Ophthalmology, Lund University, Lund,
Sweden
3602 — B0042 Electrophysiology and anatomy
of the retina in albinism: is there a correlation
with visual acuity? Arlene V. Drack1, Z. hu1, T.
Kehoe1, A. Kemerley2, 3, M. Helms1, S. Bhattarai1,
W. Pfeifer1.1Ophthalmology, Univ of Iowa Hospitals
and Clinics, Iowa City, IA; 2University of Iowa,
Iowa City, IA; 3University of Des Moines,
Des Moines, IA *CR
3603 — B0043 Longitudinal study of retinal
and optic nerve function in patients with
multiple sclerosis - a baseline report. Christina
Gerth-Kahlert, K. Landau, J. V. Hanson. University
of Zurich, Zurich, Switzerland *CR
3604 — B0044 Visual Evoked Potential (VEP)
Testing and Craniofacial Synostosis (CS):
Results in 67 Patients. Simone L. Li, R. W. Hertle,
W. Lawhon, N. Hanna, A. Patel, A. Murthy, T. Chen.
Ophthalmology, Akron Children’s Hospital,
Akron, OH
3605 — B0045 Repeatability And
Reproducibility Of Short-Duration Transient
Visual Evoked Potentials In Normal Older
Adults. Rick Trevino, C. Majcher, A. Henry, U. Bui,
W. E. Sponsel. Rosenberg School of Optometry,
University of the Incarnate Word, San Antonio, TX
Exhibit/Poster Hall B0153-B0163a
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Anatomy and Pathology/Oncology
342 Genes and proteins in myopia:
Humans and Animal models
3606 — B0153 Whole Exome Sequencing
Identifies a Rare Variant Co-segregating with
High Myopia. Bethany A. Kloss1, S. W. Tompson1,
K. Whisenhunt1, S. J. Huang1, T. Rosenberg2, T. L.
Young1.1University of Wisconsin, Madison, WI;
2
National Eye Clinic, Kennedy Center, Glostrup,
Denmark
3607 — B0154 Replication of known loci and
suggestive linkage for Familial Myopia on three
chromosomes in African-Americans. Joan E.
Bailey-Wilson1, A. M. Musolf1, C. L. Simpson1,
L. Portas2, 1, F. Murgia2, 1, Q. Li1, D. Stambolian3.
1
Computational and Statistical Genomics Branch,
National Human Genome Research Institute, NIH,
Baltimore, MD; 2Institute of Population Genetics,
Sassari, Italy; 3Ophthalmology, University of
Pennsylvania, Philadelphia, PA
3608 — B0155 Genome-wide DNA methylation
analysis and epigenetic variations associated
with High-Grade Myopia. Kereena Chukka.
Department of Biotechnology, Acharya Nagarjuna
University, Guntur, India
3609 — B0156 Mfrp regulates ocular growth in
mice and interacts with Prss56. Mark P. Krebs, W.
Hicks, P. M. Nishina. The Jackson Laboratory, Bar
Harbor, ME
3610 — B0157 lrp2-/- zebrafish eyes show
modulation of multiple genetic pathways,
including Bmp signaling, that cause myopia.
Brian Link, A. L. Pavlovich, J. Bader, J.
C. Besharse, R. F. Collery. Cell Biology,
Neurobiology, and Anatomy, Medical College of
Wisconsin, Milwaukee, WI
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
247
Tuesday Posters
11:00 am – 12:45 pm
3593 — B0033 Evaluation of the RETeval 30
Hz Flicker ERG in the Assessment of Diabetic
Patients. Ange-Lynca Kantungane2, 1, V. Popovic1,
M. Faris1, 2, J. Hamilton2, 1, S. Coupland2, 1.
1
ophthalmology, University of Ottawa Eye Institute,
Ottawa, ON, Canada; 2ophthalmology, Ottawa
Hospital Research Institute, Ottawa, ON, Canada
*CR
3596 — B0036 The light adaptation
phenomenon in human: receptoral and postreceptoral involvement. Alódia Brasil5, 1, T.
I. Tsai1, G. S. Souza5, 2, A. M. Herculano5, D.
F. Ventura3, L. L. Silveira5, 6, J. J. Kremers1, 4.
1
Ophthalmology, Friedrich-Alexander-UniversitatErlangen-Nurnberg, Erlangen, Germany; 2Núcleo
de Medicina Tropical, Universidade Federal do
Pará, Belém, Brazil; 3Experimental Psychology,
University of São Paulo, São Paulo, Brazil;
4
Anatomy II, Friedrich-Alexander-UniversitatErlangen-Nurnberg, Erlangen, Germany;
5
Biological Sciences Institute, Federal University of
Para, Belém, Brazil; 6Ceuma University,
Sao Luis, Brazil
3611 – 3630 – Tuesday – Posters
3611 — B0158 Systematic integrated
comparison of omics studies highlights
similarities in the biological basis of animal and
human myopia. Nina Riddell, L. Giummarra, S. G.
Crewther. Psychology and Public Health, La Trobe
University, Melbourne, VIC, Australia
3612 — B0159 Proteomic analysis implicates
energy metabolism in recovery from FDM.
Loretta Giummarra, N. Riddell, S. G. Crewther.
Psychology & Public Health, La Trobe University,
Melbourne, VIC, Australia
3613 — B0160 Functional contribution by
PPARα expression to emmetropization in mice.
Chanyi Lu, J. Ke, J. Yan, M. Zheng, J. Qu, X. Zhou.
Wenzhou Medical University, School of Optometry
and Ophthalmology | Eye Hospital, Wenzhou, China
3614 — B0161 Declines in FP receptor-linked
signaling may contribute to form-deprived
myopic development in guinea pigs. jinglei yang.
Wenzhou Medical University, Wenzhou, China
Tuesday Posters
11:00 am – 12:45 pm
3615 — B0162 Reduced mRNA expression
of apolipoproteinD is associated with recovery
from myopia in guinea pig retina. Lena D.
Fuchs1, M. P. Feldkaemper2, S. A. McFadden1.
1
Behavioural Sciences, University of Newcastle,
Australia, Newcastle, NSW, Australia; 2Section of
Neurobiology of the Eye, Institute for Ophthalmic
Research, Tuebingen, Germany
3616 — B0163 Eliminating the Master Clock
Gene in the Murine Retina Produces Myopia.
Duk Cheon Lee5, R. Chakraborty1, 5, P. Iuvone1, 2,
R. A. Stone3, M. T. Pardue5, 4. 1Ophthalmology,
Emory University, Atlanta, GA; 2Pharmacology,
Emory University, Atlanta, GA; 3Ophthalmology,
University of Pennsylvania, Philadelphia, PA;
4
Biomedical Engineering, Georgia Institue
of Technology / Emory University, Atlanta,
GA;5Center for Visual and Neurocognitive
Rehabilitation, Atlanta VA center, Decatur, GA
3616a — B0163a Alkaline Phosphatase
Enriched Exosomes as Guidance Cues in the
Developing Avian Optic Chiasm. Daniel Elefant1,
I. Hernandez-Morato1, J. Kumaratilake2, S. C.
Sharma1, S. A. Newman1. 1New York Medical
College, Valhalla, NY; 2University of Adelaide,
Australia, Adelaide, SA, Australia
Exhibit/Poster Hall B0220-B0231
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Biochemistry/Molecular Biology
343 Retinoids and carotenoids: Visual
cycle and macular pigment
Moderator: Lu Chen
3617 — B0220 Retinal and RPE/Choroid
Uptake of Lutein, Zeaxanthin, and β-Carotene in
Mice. Preejith P. Vachali1, B. Li1, A. Gorusupudi1,
Z. Shen3, B. M. Besch2, S. Longo3, K. Nelson1, P. S.
Bernstein1.1Ophthalmology, University of Utah, Salt
Lake City, UT; 2School of Medicine, University of
Utah, Salt Lake City, UT; 3University of Utah,
Salt Lake City, UT
3618 — B0221 In vivo Mechanisms of mesoZeaxanthin Production. Paul S. Bernstein, R.
Shyam, A. Gorusupudi, B. Li, P. P. Vachali, K.
Nelson. Department of Ophthalmology, Univ of
Utah/Moran Eye Center, Salt Lake City, UT
3619 — B0222 Macular pigment spatial profile
classification: are our eyes deceiving us? Byki
Huntjens, I. Ctori. Optometry and Visual Science,
City University London, London, United Kingdom
3620 — B0223 Do ethnic variations in foveal
morphology explain variations in macular
pigment spatial density distribution? Irene Ctori,
B. Huntjens. Optometry and Visual Science, City
University London, London, United Kingdom
3621 — B0224 RPE-specific knock-out of
Retinol Dehydrogenase 10 altered retinoid
profile. Younghwa Shin1, G. P. Moiseyev1, K.
M. Farjo1, Y. Takahashi2, J. Ma1. 1Physiology,
University of Oklahoma HSC, Oklahoma City, OK;
2
Endocrinology, University of Oklahoma HSC,
Oklahoma City, OK
3622 — B0225 Role of CD36 in Carotenoid
Transport in the Vertebrate Eye. Rajalekshmy
Shyam, P. P. Vachali, A. Gorusupudi, P. S.
Bernstein. Ophthalmology, University of Utah,
Salt Lake City, UT
3623 — B0226 Sodium 4-Phenylbutyrate
Improves Cone Survival and Function in a
Mouse Model for Leber Congenital Amaurosis.
Songhua Li1, M. Samardzija2, Z. Yang1, C.
Grimm2, M. Jin1. 1Department of Ophthalmology,
LSU Health Sciences Center, New Orleans, LA;
2
Department of Ophthalmology, University of
Zurich, Zurich, Swaziland
3624 — B0227 Crystal Structure of the
Human Lutein-Binding Protein (StARD3)
Binding Domain with Phase Extension to 1.74
Å Resolution. Binxing Li1, M. P. Horvath2, E. W.
George2, Q. Tran2, S. Shihab1, T. Mattinson1, P. S.
Bernstein1. 1Department of Ophthalmology, Univ
of UT Sch Med/Moran Eye Ctr, Salt Lake City, UT;
2
Department of Biology, University of Utah,
Salt Lake City, UT
3625 — B0228 Heterologous Expression of
Functional PDE6 Requires Cooperative Action
of AIPL1 and the Inhibitory Pγ-subunit. Kota
Gopalakrishna, K. Boyd, N. Artemyev. Molecular
Physiology and Biophysics, University of Iowa,
Iowa City, IA
3626 — B0229 Acyl-CoA synthetase and
N-terminal regions of fatty acid transport
protein 4 (FATP4) are important for interacting
with and inhibiting RPE65 isomerase of the
visual cycle. Minghao Jin, J. F. Green, S. Adtani, S.
Li. Department of Ophthalmology, LSU School of
Medicine, New Orleans, LA
3627 — B0230 The Photosensitivity of
Rhodopsin and the Spectral Reflectivity of the
Mouse Fundus Measured in Vivo with Scanning
Laser Ophthalmoscopy. Pengfei Zhang1, M.
Goswami1, R. J. Zawadzki1, 2, E. N. Pugh1. 1Cell
Biology and Human Anatomy, University of
California, Davis, Davis, CA; 2Ophthalmology &
Vision Science, UC Davis, Sacramento, CA
3628 — B0231 Interrelationships between
Macular, Skin, and Serum Carotenoids.
Christopher D. Conrady, J. E. Bell, B. M. Besch,
A. Gorusupudi, W. Gellermann, K. Farnsworth, P.
S. Bernstein. Ophthalmology, University of Utah Moran Eye Center, Salt Lake City, UT *CR
Exhibit/Poster Hall B0301-B0330
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Retinal Cell Biology
344 Angiogenesis: Molecular and
Cellular Effectors I
Moderator: Baerbel Rohrer
3629 — B0301 Retinal HIF-1α and VEGF
levels differ between C57BL/6N and C57BL/6J
mice with hyperoxia induced lung injury.
Michelle Lajko1, H. J. Cardona2, J. M. Taylor2, K.
N. Farrow2, A. A. Fawzi1. 1Dept of Ophthalmology,
Feinberg School of Medicin at Northwestern
University, Chicago, IL; 2Dept of Pediatrics,
Feinberg School of Medicine at Northwestern
University, Chicago, IL
3630 — B0302 Nuclear receptor RORa
regulates retinal inflammation and
neovascularization in retinopathy through
SOCS3. Chi-Hsiu Liu1, Y. Sun1, J. SanGiovanni2,
L. Evans1, K. Tian1, A. Stahl3, T. Kamenecka4, L.
Solt4, J. Chen1. 1Department of Ophthalmology,
Boston Children’s Hospital, Boston, MA; 2National
Institutes of Health, Bethesda, MD; 3University of
Freiburg, Freiburg, Germany; 4the Scripps Research
Institute, Jupiter, FL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
248
Tuesday – Posters – 3631 – 3649
3631 — B0303 Comparative Systems
Pharmacology of HIF Stabilization in the
Prevention of Retinopathy of Prematurity.
George Hoppe1, S. Yoon1, B. Gopalan2, R. Brown1,
K. Case1, A. Vasanji3, E. R. Chan4, J. E. Sears1, 5.
1
Cole Eye Institute, Cleveland Clinic, Cleveland,
OH; 2Yorg Corp, Plano, TX; 3ImageIQ Inc,
Cleveland, OH; 4Institute for Computational
Biology, Case Western Reserve University School
of Medicine, Cleveland, OH; 5Cellular and
Molecular Medicine, Cleveland Clinic, Cleveland, OH
3632 — B0304 A study of ocular blood flow in
oxygen-induced ischemic retinopathy model rats
using Laser Speckle Flowgraphy-Micro. Tadashi
Matsumoto1, Y. Saito2, T. Itokawa1, T. shiba1, H.
Takahashi2, Y. Hori1. 1Toho University Omori
Medical Center, Ota-ku, Japan; 2School of Medicine
Showa University, Tokyo, Japan
3633 — B0305 Following an oxygen-induced
retinopathy Wnt/β-catenin signaling in
microvascular endothelial and Müller cells is
essential for vascular repair. Andreas Ohlmann,
B. B. Mueller, D. Woehl, E. R. Tamm. Dept. of
Anatomy, University of Regensburg, Regensburg,
Germany
3635 — B0307 The Role of Hyperoxia-Induced
Vaso-obliteration of Cerebral Blood Vessels
and Glycolysis in the Development of ROP and
PVL. Lingkun Kong1, H. leeming1, C. Patel2, K.
B. Ghaghada2, K. W. Wright3. 1Ophthalmology,
Baylor College of Medicine, Houston, TX; 2The
Singleton Department of Pediatric Radiology, Texas
Children’s Hospital, Houston, TX; 3Ophthalmology,
Keck School of Medicine, Los Angeles, CA
3636 — B0308 Non-vascular alterations and
functional impairment persist after Anti-VEGF
therapy in Oxygen Induced Retinopathy (OIR)
mouse model. Magali E. Ridano1, V. E. Lorenc1, 2,
P. Subirada1, M. Paz1, D. O. Croci Russo3, J. D.
Luna Pinto4, G. A. Rabinovich3, M. C. Sanchez1.
1
Department of Clinical Biochemistry, Faculty of
Chemical Sciences, National University of Córdoba,
CICIBI-CONICET, Córdoba capital, Argentina;
2
Department of Ophthalmology, The Johns Hopkins
School of Medicine, Baltimore, MD; 3Faculty of
Medicine, University of Buenos Aires, IByMECONICET, Capital Federal, Argentina; 4Private
Eye Center Romagosa, VER Foundation, Córdoba
capital, Argentina
3638 — B0310 Inhibition of Uncoupling Protein
2 Promotes Postnatal Growth and Physiologic
Retinal Vascular Development in a Rat Model
of Oxygen Induced Retinopathy. Xiaokun Han1, 2,
A. J. Liu1, E. Kunz1, C. A. Bretz1, M. Hartnett1, H.
Wang1. 1Department of Ophthalmology, Moran
Eye Center, University of Utah, Salt Lake City,
UT; 2Department of Ophthalmology, The Fourth
Affiliated Hospital of China Medical University,
Shenyang, China
3639 — B0311 Ferrochelatase is required
for retinal neovascularization. Halesha D.
Basavarajappa1, 2, L. C. Shaw1, S. L. Calzi1, K.
Sishtla1, M. B. Grant1, T. W. Corson1, 2. 1Department
of Ophthalmology, Indiana University School
of Medicine, Indianapolis, IN; 2Department of
Biochemistry and Molecular Biology, Indiana
University School of Medicine, Indianapolis, IN
*CR
3640 — B0312 Dysregulated autophagy
contributes to pathological angiogenesis in a
mice model of retinal angiomatous proliferation.
Heckel E, Pundir S, Patel G, Kim JS, Lacombe
MJ, Saba N, Fredrick T, Sun Y, Smith LEH,
Joyal JS. Emilie Heckel1, S. Pundir1, G. Patel1, J.
Kim Suang1, L. Marie Josee1, N. Saba2, T. Fredrick2,
L. E. Smith2, J. Joyal1. 1Pharmacology, CHU SainteJustine, Montreal, QC, Canada; 2Childrens.Harvard,
Boston, MA
3641 — B0313 Erythropoietin receptor
signaling contributes to the development of
pathologic retinal angiogenesis. Colin A. Bretz1,
H. Wang1, S. Becker1, V. Divoky2, M. Hartnett1.
1
Ophthalmology, John A Moran Eye Center, Salt
Lake City, UT; 2Biology, Palacky University,
Olomouc, Czech Republic
3642 — B0314 Neovascular changes and
angiogenic factor production during combined
intrauterine growth restriction and oxygeninduced retinopathy. Silke Becker1, H. Wang1, B.
Yu3, R. H. Lane2, M. Hartnett1. 1John A. Moran Eye
Center, University of Utah, Salt Lake City, UT;
2
Children’s Hospital of Wisconsin, Wilwaukee, WI;
3
Department of Neonatology, University of Utah,
Salt Lake City, UT
3643 — B0315 Myeloid cell ER-stress
contributes to pathological retinal
neovascularisation in ischemic retinopathy.
Gaëlle Mawambo1, A. Dejda2, K. Miloudi3, P.
Sapieha1, 2. 1Biochemistry, University of Montreal,
Montreal, QC, Canada; 2Ophthalmology,
Maisonneuve-Rosemont Hospital Research
Centre, Montreal, QC, Canada; 3Neurology and
Neurosurgery, McGill University, Montreal, QC,
Canada
3644 — B0316 Receptor-independent
activation of Wnt Signaling protects retinal
vasculature and visual function in a mouse
model of familial exudative vitreoretinopathy.
Zhongxiao Wang, C. Liu, Y. Sun, Y. Gong, J. D.
Akula, J. Chen, T. Favazza, N. Saba, T. Fredrick,
P. Morss. Ophthalmolopgy, Boston Children’s
Hospital, Boston, MA
3645 — B0317 PEDF Expression Regulates
Retinal Endothelial Cell Proangiogenic
Properties through Modulation of Extracellular
Matrix and Cell Junctional Proteins. Nader
Sheibani2, 1, S. Park2, J. Falero-Perez2, C. M.
Sorenson3, 1. 1McPherson Eye Research Institute,
Univ of Wisconsin-Madison, Madison, WI;
2
Ophthalmology, University of Wisconsin-Madison,
Madison, WI; 3Pediatrics, University of WisconsinMadison, Madison, WI
3646 — B0318 Thrombospodin-1 Inhibition
of Neovascularization in the Retina and Jaw
as a Contributing Factor in BisphosphonateRelated Osteonecrosis of the Jaw (BRONJ).
Bennett McAllister1, T. Harris1, J. Borke2, S. Kang2,
S. Nakasato2, J. Elo2, S. Fulzele3, C. Guerra2.
1
College of Optometry, Western University of
Health Sciences, Pomona, CA; 2College of Dental
Medicine, Western University of Health Sciences,
Pomona, CA; 3Medical College of Georgia, Augusta
University, Augusta, GA
3647 — B0319 Old player, new game:
supplementing, rather than inhibiting,
CCL2 may more effectively limit retinal
neovascularization. Salome Murinello1, P.
D. Westenskow1, 2, E. Aguilar1, A. Schrick3, M.
Friedlander1. 1Cell and Molecular Biology, The
Scripps Research Institute, La Jolla, CA; 2The Lowy
Medical Research Institute, La Jolla, CA; 3Point
Loma Nazarene University, San Diego, CA
3648 — B0320 Role of gremlin, an agonist of
vascular endothelial growth factor receptor 2, in
retinal angiogenesis. Sang Jin Kim1, 2, J. YUN2, J.
Kim2. 1Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Korea (the Republic of); 2Samsung
Biomedical Research Institute, Seoul, Korea
(the Republic of)
3649 — B0321 Intravitreal injection of PBS
reduces retinal neovascularization in the mouse
oxygen-induced retinopathy model. Maria
Vähätupa1, 2, H. Uusitalo-Järvinen1, 3, T. Järvinen4, 3,
H. M. Uusitalo1, 3, G. Kalesnykas2, 1. 1Department of
Ophthalmology, University of Tampere, Tampere,
Finland; 2Experimentica Ltd., Kuopio, Finland;
3
Tampere University Hospital, Tampere, Finland;
4
Department of Anatomy, University of Tampere,
Tampere, Finland *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
249
Tuesday Posters
11:00 am – 12:45 pm
3634 — B0306 Sirt3-deficient retina
revascularizes faster by shifting cellular
metabolism towards glycolysis in a mouse model
of proliferative retinopathy. Sheetal Pundir1, 2,
E. Heckel3, 2, J. Kim Suang1, 2, G. Patel3, 2, L. Marie
Josee2, D. Toledano2, J. Joyal1, 2. 1Pharmacology &
Therapeutics, McGill University, Montreal, QC,
Canada; 2Research, CHU-St. Justine Hospital,
Montreal, QC, Canada; 3Pharmacology, University
of Montreal, Montreal, QC, Canada
3637 — B0309 Endomucin inhibits VEGFinduced endothelial cell migration, growth,
and morphogenesis by suppressing VEGFR2
signaling. Patricia A. D’Amore, C. Park-Windhol,
Y. Ng, J. Yang, V. Primo, M. Saint-Geniez.
Ophthalmology, Schepens Eye Res Inst, MEEI,
Boston, MA *CR
3650 – 3666 – Tuesday – Posters
3650 — B0322 Role of the BMP9/Alk1
signaling pathway for the prevention of
pathological neovascularization. Bruno
Larrivee1, 2, K. Ntumba2. 1Ophthalmology,
Université de Montréal, Montreal, QC,
Canada;2Hôpital Maisonneuve-Rosemont, Montreal,
QC, Canada
3651 — B0323 Sustained Intravitreal Drug
Delivery with Injectable Polymer-Nanoparticle
Hydrogels. Mark W. Tibbitt1, E. A. Appel2, A.
Jayagopal3, R. Langer1. 1Koch Institute for
Integrative Cancer Research, Massachusetts
Institute of Technology, Cambridge, MA;
2
Department of Materials Science & Engineering,
Stanford University, Stanford, CA; 3Pharma
Research and Early Development, Ophthalmology
Discovery and Biomarkers, Roche Innovation
Center Basel, F. Hoffmann-La Roche Ltd, Basel,
Switzerland *CR
Tuesday Posters
11:00 am – 12:45 pm
3652 — B0324 Bone marrow derived
CX3CR1+ progenitors facilitate vascular repair
in a murine model of ischemic retinopathy.
Edith Aguilar, S. Sakimoto, S. Murinello, P. D.
Westenskow, Y. Usui, F. Bucher, M. Kitano, D.
Feitelberg, M. Friedlander. Cell Biology, Scripps
Research Institute, Del Mar, CA
3653 — B0325 Regulation of oxidative
stress and inflammation by Nrf2 improves
revascularization in oxygen-induced retinopathy.
Yanhong Wei1, J. gong1, R. K. Thimmulappa2, S.
Biswal2, E. J. Duh1.1Ophthalmology, Johns Hopkins
University School of Medicine, Baltimore, MD;
2
Environmental Health Sciences, Bloomberg
School of Public Health, Johns Hopkins University,
Baltimore, MD
3654 — B0326 Effects of human endothelial
colony forming cells on oxygen induced
retinopathy in various immune competent celldepleted mice. Susumu Sakimoto1, E. Aguilar1, V.
Marchetti2, S. Murinello1, Y. Usui1, F. Bucher1, D.
Feitelberg1, J. K. Trombley1, P. D. Westenskow1,
M. Friedlander1. 1Cell and Molecular Biology, The
Scripps Research Institute, La Jolla, CA; 2Stemcell
Technologies, Vancouver, BC, Canada *CR
3655 — B0327 Preventing pathological
angiogenesis in the retina using a microRNA
that regulates endothelial cell survival. Daniel
Feitelberg1, F. Bucher1, P. D. Westenskow1, E.
Aguilar1, Y. Usui1, S. Murinello1, C. M. Wittgrove1,
P. Keshavarzian2, S. Weis2, D. Cheresh2, M.
Friedlander1. 1Department of Cell and Molecular
Biology, The Scripps Research Institute, La Jolla,
CA; 2Department of Pathology and Moores Cancer
Center, University of Calfornia, San Diego,
La Jolla, CA
3656 — B0328 The role of DNA repair in
the choice between sprouting or proliferating
angiogenesis in the context of proliferative
retinopathies. Matina Economopoulou1, M.
Troulinaki2, R. Garcia-Martin2, L. E. Pillunat1,
A. Nussenzweig3, T. Chavakis2. 1Ophthalmology,
University clinic, TU Dresden, Dresden, Germany;
2
IKL, University Clinic, TU Dresden, Dresden,
Germany; 3NCI, NIH, Bethesda, MD
3657 — B0329 Disruption of astrocytic gap
junctions promotes revascularization and
diminishes abnormal vessel growth in oxygeninduced retinopathy. Nefeli Slavi1, J. Ackert1,
H. Wulff2, M. Srinivas1.1Biological and Vision
Sciences, SUNY College of Optometry, New York,
NY; 2Pharmacology, University of California,
Davis, California, CA
3658 — B0330 Use of endothelial colony
forming cell vesicles to modulate retinal
angiogenesis. Margaret Dellett, E. Brown, J.
Guduric-Fuchs, R. Medina, D. A. Simpson. Centre
for Experimental Medicine, Queen’s University
Belfast, Belfast, United Kingdom
Exhibit/Poster Hall C0133-C0161
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Anatomy and Pathology/Oncology
345 What is New in Retinoblastoma?
Moderators: Matthew W. Wilson and
Timothy W. Corson
3659 — C0133 Decreasing cell survival in
Retinoblastoma through PDGFR- β blockade.
Zachary Goldsmith1, V. M. Morales1, 3, M. McEwen1,
W. Coppess1, A. Irvine1, R. C. Brennan1, 2, M. W.
Wilson1, 4.1Ophthalmology, University of Tennessee
Health Science Center, Memphis, TN; 2Oncology,
St. Jude Children’s Research Hospital, Memphis,
TN; 3Microbiology, Immunology and Biochemistry,
University of Tennessee Health Science Center,
Memphis, TN; 4Surgery, St. Jude Children’s
Research Hospital, Memphis, TN
3660 — C0134 Determining the Role of
Adhesion G-Protein Coupled Receptors in
Retinoblastoma. Jonathan Guihurt Santiago,
R. Herrera Camacho, J. Flores Otero. Anatomy
and Neurobiology, UPR-RCM Institute of
Neurobiology, San Juan, PR
3662 — C0136 Hypoxia and Notch inhibition
both enhance sensitivity of Retinoblastoma cells
to Melphalan. Laura Asnaghi, Q. Yang, A. Tripathy,
A. Hanaford, H. Kaur, C. Eberhart. Johns Hopkins
University, Baltimore, MD
3663 — C0137 Gene Expression Profiles
of Retinoblastoma Cells with Different
Proliferation Patterns: Focusing on Genes
Regarding Cell-to-Cell and Cell-to-Matrix
Adhesion. Do Yeh Yoon2, 1, D. Jo2, 3, J. Kim2, 4,
Y. Yu2, 1, J. Kim2, 3. 1Ophthalmology, College of
Medicine, Seoul National University, Seoul, Korea
(the Republic of); 2Fight against AngiogenesisRelated Blindness (FARB) Laboratory, Clinical
Research Institute, Seoul, Korea (the Republic of);
3
Biomedical Sciences, College of Medicine, Seoul
National University, Seoul, Korea (the Republic of);
4
Tumor Microenvironment Research Center, Global
Core Research Center, Seoul National University,
Seoul, Korea (the Republic of)
3664 — C0138 Expression of Stem Cell
Markers: ABCG2, MCM2 and C-kit in
Retinoblastoma. Bhavna Chawla1, A. Gadkar1, S.
Mohanty2, M. Sharma2. 1Rajendra Prasad Centre for
Ophthalmic Sciences, All India Institute of Medical
Sciences, New Delhi, India; 2Stem Cell Facility, All
India Institute of Medical Sciences,
New Delhi, India
3665 — C0139 Looking for the best
retinoblastoma mouse model using in vivo
spectral domain optical coherence imaging.
Stephanie Lemaitre1, 3, F. Poyer1, N. Cassoux2, 3, F.
Doz5, L. Desjardins2, P. Freneaux4, C. Thomas1.
1
CMIB : Chemistry, Modelling and Imaging
for Biology, Institut Curie, ORSAY, France;
2
Ophtalmology oncology, Institut Curie, Paris,
France; 3Université Paris Descartes, PARIS,
France; 4Biopathology, Institut Curie, Paris, France;
5
Pediatric Oncology, Institut Curie, Paris, France
3666 — C0140 Preclinical Acute Safety Study
of Combined Intravitreal Carboplatin, Etoposide
Phosphate, and Topotecan for Retinoblastoma
with Vitreous Seeding. Stephen J. Smith1, H. E.
Grossniklaus2, A. Smith4, V. Elner1, J. Harbour3, B.
Smith5, B. G. Mohney6. 1Ophthalmology, University
of Michigan, Ann Arbor, MI; 2Ophthalmology,
Emory University, Atlanta, GA; 3Ophthalmology,
UNiversity of Miami, Bascom Palmer Eye Institute,
Miami, FL; 4SUNY Brockport, Rochester, NY;
5
Hematology/Oncology, University of Rochester,
Rochester, NY; 6Ophthalmology, Mayo Clinic,
Rochester, MN
3661 — C0135 Growth hormone-releasing
hormone (GHRH) antagonist induces apoptosis
in retinoblastoma. WAI KIT CHU1, F. Li1, K.
Law1, S. CHAN2, H. Cheung4, A. Schally3, C. C.
Pang1. 1Department of Ophthalmology and Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, Hong Kong; 2School of Biomedical
Sciences, The Chinese University of Hong Kong,
Hong Kong, Hong Kong; 3Endocrine, Polypeptide
and Cancer Institute, University of Miami, Miami,
FL; 4Department of Biomedical Engineering,
University of Miami, Miami, FL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
250
Tuesday – Posters – 3667 – 3687
3667 — C0141 A novel rabbit model of
intraarterial chemotherapy / ophthalmic
artery chemosurgery. Anthony B. Daniels8, 9,
M. T. Froehler2, J. M. Pierce1, A. Nunnally4, T.
M. Bridges5, D. L. Friedman6, 9, A. Richmond7, 3.
1
Ophthalmology and Visual Sciences, Vanderbilt
Eye Institute, Nashville, TN; 2Cerebrovascular
Program, Vanderbilt University Medical Center,
Nashville, TN; 3Cancer Biology, Vanderbilt
University, Nashville, TN;4Surgical Research,
Vanderbilt University Medical Center, Nashville,
TN; 5Pharmacology, Vanderbilt University,
Nashville, TN; 6Pediatrics, Vanderbilt University
Medical Center, Nashville, TN; 7Tennessee Valley
Healthcare System, Department of Veterans
Affairs, Nashville, TN; 8Ophthalmology and Visual
Sciences, Cancer Biology, and Radiation Oncology,
Vanderbilt University Medical Center, Nashville,
TN; 9Vanderbilt-Ingram Cancer Center, Vanderbilt
University Medical Center, Nashville, TN
3668 — C0142 Rabbit model of ocular
photodynamic therapy using an indirect
ophthalmoscope delivery system. Jonathan W.
Kim1, 2, P. Chevez-Barrios3. 1Children’s Hospital
Los Angeles, Los Angeles, CA;2Ophthalmology,
USC Eye Institute, Los Angeles, CA; 3Pathology,
Methodist Hospital, Houston, TX
3670 — C0144 The Value of “en toto” globe
submission in the assessment of high risk
retinoblastoma cases and subsequent plan for
treatment. Hani ALBalawi1, H. Al-Khatan2, A.
Maktabi3. 1University Of Tabuk, Tabuk, Saudi
Arabia; 2King Saud University, Riyadh, Saudi
Arabia; 3King Khaled Eye specialist Hospital,
Riyadh, Saudi Arabia
3671 — C0145 Increased Frequency of Positive
Family History of Retinoblastoma in Recently
Encountered Cases. Rafaela Faraj, Z. M. Correa,
J. J. Augsburger. Ophthalmology, University of
Cincinnati, Cincinnati, OH
3672 — C0146 The clinical presentation of
retinoblastoma patients with mosaics. Shahar
Frenkel, J. Pe’er. Ophthalmology, HadassahHebrew Univ Med Ctr, Jerusalem, Israel
3673 — C0147 Fluorescein Angiography
Findings in Diffuse Retinoblastoma: Two Case
Reports With Clinicopathologic Correlation.
Maria Paula Fernandez1, S. N. Al-Holou3, O. G.
Fischer1, A. M. Berrocal2, S. R. Dubovy1. 1Ocular
Pathology Laboratory, bascom Palmer Eye Institute,
Miami, FL; 2Bascom Palmer Eye Institute, Mimai,
FL; 3Henry Ford Hospital, Detroit, MI
3676 — C0150 An International Survey of
Classification and Treatment Choices for Group
D Retinoblastoma Eyes. Christina Scelfo1, J.
H. Francis1, T. L. Jenkins2, B. P. Marr1, D. H.
Abramson1. 1Memorial Sloan Kettering Cancer
Center, New York, NY; 2WillsEye Hospital,
Philadelphia, PA
3677 — C0151 Visual outcomes of macular
retinoblastoma tumors treated with systemic
chemotherapy and repetitive laser ablation.
Julia Sein, G. Lueder. Ophthalmology, Washington
University in St. Louis, St Louis, MO
3678 — C0152 Anterior chamber seeding in
retinoblastoma: is it an indication for adjuvant
chemotherapy. A long term follow up study.
Vikas Khetan, S. Krishnakumar, S. Kummamuri,
A. Ramesh. Ophthalmology, Sankara Nethralaya,
Chennai, India
3679 — C0153 Brachytherapy with Ru106 plaques as a primary treatment for
retinoblastoma in Israel. Jacob Pe’er, S. Frenkel.
Ophthalmology, Hadassah-Hebrew University
Medical Center, Jerusalem, Israel
3680 — C0154 Retinal reattachment and ERG
recovery after ophthalmic artery chemosurgery
for advanced retinoblastoma in eyes with
minimal baseline retinal function. Aliaa H.
Abdelhakim1, J. H. Francis1, 2, P. Gobin1, 3, B.
P. Marr1, 2, D. H. Abramson1, 2, S. E. Brodie1, 4.
1
Ophthalmic Oncology, Memorial Sloan Kettering
Cancer Center, New York, NY; 2Ophthalmology,
Weill Cornell Medical College, New York, NY;
3
Interventional Neuroradiology, Weill Cornell
Medical College, New York, NY; 4Ophthalmology,
Icahn School of Medicine at Mount Sinai,
New York, NY
3681 — C0155 Dynamics of New Tumor
Development during and after Chemotherapy
against Retinoblastoma: Groundwork for
Novel Translational Approaches. Dong Hyun
Jo2, 1, J. Kim2, 3, Y. Yu2, 4, J. Kim2, 1. 1Department of
Biomedical Sciences, College of Medicine, Seoul
National University, Seoul, Korea (the Republic
of); 2Fight against Angiogenesis-Related Blindness
(FARB) Laboratory, Clinical Research Institute,
Seoul National University Hospital, Seoul, Korea
(the Republic of); 3Tumor Microenvironment
Research Center, Global Core Research Center,
Seoul National University, Seoul, Korea (the
Republic of); 4Department of Ophthalmology,
College of Medicine, Seoul National University
Hospital, Seoul, Korea (the Republic of)
3682 — C0156 Concomitant first line
intra-arterial (IAC) and intra-vitreal (IVC)
chemotherapy with melphalan for unilateral
group D retinoblastoma (Rb) with diffuse
vitreous seeding at presentation.Francis L.
Munier1, M. Gaillard1, C. Stathopoulos1, M.
Beck-Popovic2, F. Puccinelli3, S. L. Houghton1.
1
Ophthalmology, Jules-Gonin Eye Hospital,
Lausanne, Switzerland; 2Pediatric HematologyOncology Unit, Centre Hospitalier Universitaire
Vaudois, Lausanne, Switzerland; 3Neuroradiology
Unit, Centre Hospitalier Universitaire Vaudois,
Lausanne, Switzerland
3683 — C0157 Multimodal analysis of macular
toxicity following intra-arterial (IAC) and/or
intravitreal (IVC) melphalan in retinoblastoma
(Rb): evidence for infra-clinical changes by optic
coherence tomography (OCT) and adaptive
optics (AO). yousra Falfoul1, A. Dirani1, M.
Gaillard1, F. Puccinelli2, M. Beck-Popovic2, F.
L. Munier1. 1Hopital Ophtalmique, Jules Gonin,
Lausanne, Switzerland; 2centre hospitalier
universitaire vaudois, Lausanne, Switzerland
3684 — C0158 Combined Melphalan/
Topotecan intra-arterial chemotherapy (MTIAC) for salvage in retinoblastoma relapse
following melphalan intra-arterial chemotherapy
(M-IAC). Anthony Manassero1, M. Gaillard2, C.
stathopoulos2, S. houghton2, F. puccinelli3, M. BeckPopovic3, F. L. Munier2. 1Fondation Rothschild,
Paris, France; 2Hopital Ophtalmique Jules Gonin,
Lausanne, Switzerland; 3CHUV, Lausanne,
Switzerland
3685 — C0159 Ophthalmic artery
chemosurgery as a local route for optic nerve
delivery of chemotherapy. Paula Schaiquevich1,
P. Taich1, F. Requejo2, M. Asprea2, M. Sgroi2,
P. Gobin3, D. H. Abramson3, G. Chantada2.
1
CONICET-Hosp de Ped JP Garrahan, Ciudad,
Argentina; 2Hospital de Pediatria JP Garrahan,
Buenos Aires, Argentina; 3Memorial Sloan
Kettering Cancer Center, NYC, NY
3686 — C0160 Acute Vaso-occlusion and
Chorioretinal Toxicity following Intravitreal
Melphalan Injection. Hassan A. Aziz, J. L. Berry,
J. W. Kim. Ophthalmology and Visual Sciences,
USC Eye Institute, Miami, FL
3687 — C0161 Intraocular Pressure Changes
Following Intravitreal Melphalan and Topotecan
for the Treatment of Retinoblastoma with
Vitreous Seeding. Matthew Karl, J. Francis, S.
Iyer, B. P. Marr, D. H. Abramson. Ophthalmology,
Memorial Sloan Kettering Cancer Center,
New York, NY *CR
3674 — C0148 Retrograde Differentiation of
Retinoblastoma in Infants. Ananth Sastry, H. A.
Aziz, J. L. Berry, J. W. Kim. Ophthalmology, USC
Eye Institute, Los Angeles, CA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
251
Tuesday Posters
11:00 am – 12:45 pm
3669 — C0143 Analysis of Nucleic Acid content
in the Aqueous Humor of Retinoblastoma Eyes.
Jesse L. Berry1, 2, J. W. Kim2, 1. 1Ophthalmology,
USC Eye Institute, Los Angeles, CA;
2
Ophthalmology, The Vision Center at Children’s
Hospital Los Angeles, Los Angeles, CA
3675 — C0149 Clinical Characterization of
Vitreous Seeds in Retinoblastoma. Jasmine
H. Francis1, 2, B. P. Marr1, 2, D. H. Abramson1, 2.
1
Ophthalmic Oncology, Memorial Sloan Kettering
Cancer Center, New York, NY; 2Ophthalmology,
Weill Cornell Medical Center, New York, NY *CR
3688 – 3707 – Tuesday – Posters
Exhibit/Poster Hall D0099-D0123
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Retina
346 AMD Clinical Research 2
Moderators: Pearse A. Keane and Yoko Ozawa
Tuesday Posters
11:00 am – 12:45 pm
3688 — D0099 Effects of central macular
thickness on visual and anatomical outcomes
in age-related macular degeneration patients:
comparison between ranibizumab and
aflibercept. Shinichi Sakamoto1, H. Takahashi1, 2,
Y. Inoue1, 3, Y. Yanagi3, 4, A. Sato1, M. Takezawa1,
T. Tanabe2, Y. Fujino2, H. Kawashima1.
1
Ophthalmology, Jichi medical university,
Shimotsuke-city, Japan; 2JCHO Tokyo Shinjyuku
Medhical Center, Tokyo, Japan; 3Ophthalmology,
Tokyo university, Tokyo, Japan; 4Singapore
National Eye Centere, Singapore, Singapore *CR
3689 — D0100 Predictive factors for nonresponse to intravitreal aflibercept treatment in
neovascular age-related macular degeneration.
Norihiro Nagai1, 2, M. Suzuki1, 2, A. Uchida2, T.
Kurihara2, M. Kamoshita1, 2, S. Minami2, H.
Shinoda2, K. Tsubota2, Y. Ozawa1, 2. 1Laboratory of
Retinal Cell Biology, Keio University, School of
Medicine, Tokyo, Japan; 2Ophthalmology, Keio
University, School of Medicine, Tokyo, Japanf
3690 — D0101 Natural History of RodMediated Dark Adaptation Over 2 Years in
Eyes with Intermediate Age-Related Macular
Degeneration. Cynthia Owsley1, M. Clark1, G.
McGwin2, 1, E. C. Strauss3.1Dept of Ophthalmology,
University of Alabama at Birmingham,
Birmingham, AL; 2Epidemiology, University
of Alabama at Birmingham, Birmingham, AL;
3
Genentech, South San Francisco, CA *CR
3691 — D0102 Face stimulus challenges
visual processing in age-related macular
degeneration. Pasi Vottonen1, K. Kaarniranta1, 2, A.
Pääkkönen3, I. M. Tarkka4. 1Ophthalmology, Kuopio
University Hospital, Kuopio, Finland; 2University
of Eastern Finland, Kuopio, Finland; 3Clinical
Neurophysiology, Kuopio University Hospital,
Kuopio, Finland; 4Health Sciences, University of
Jyväskylä, Jyväskylä, Finland
3692 — D0103 Low energy stereotactic
radiotherapy in combination with an anti VEGF
treat and extend regimen for treatment of
neovascular age related macular degeneration:
12 month outcomes. Katja B. Hatz1, 2, F.
Zimmermann3, D. Kardamakis4, E. Lazaridis5,
C. Tuerksever1, 2, C. Pruente1, 2. 1Vista Klinik,
Binningen, Switzerland; 2Dep. of Ophthalmology,
Kantonsspital Baselland, Liestal, Switzerland; 3Dep.
of Radiooncology, University Hospital Basel, Basel,
Switzerland; 4Dep. of Radiooncology, Medical
School Patras, Patras, Greece; 5EyeRAD SWISS
Medical Center, Basel, Switzerland *CR
3693 — D0104 One-year Outcomes following
Intravitreal Aflibercept for Polypoidal Choroidal
Vasculopathy in Japanese Patients: The
APOLLO study. Yuji Oshima1, K. Kimoto2, N.
Yoshida3, K. Fujisawa4, S. Sonoda5, T. Kubota2, T.
Murata3, T. Sakamoto5, K. Sonoda1, T. Ishibashi1.
1
Ophthalmology, Graduate School of Medical
Sciences, Kyushu University, Fukuoka, Japan;
2
Ophthalmology, Oita University Faculty of
Medicine, Yufu, Japan; 3Ophthalmology, Shinshu
University School of Medicine, Matsumoto,
Japan; 4Ophthalmology, Japan Community Health
care Organization Kyushu Hospital, Kitakyushu,
Japan; 5Ophthalmology, Kagoshima University
Graduate School of Medical and Dental Sciences,
Kagoshima, Japan *CR, f
3694 — D0105 Comparative study of different
methods for analyzing correlated continuous
data. Bernard Rosner1, G. Ying2, R. Glynn1, M.
G. Maguire2. 1Medicine (Biostatistics), Harvard
Medical School, Boston, MA; 2Ophthalmology,
Perelman School of Medicine, University of
Pennsylvania, Philadelphia, PA
3695 — D0106 Systemic confounders for serum
patterns of omega-3- and -6-polyunsaturated
fatty acids in patients with different retinal
pathologies. Anima Buehler1, M. Augustynik1, F.
Bucher1, J. Wöhrl2, G. Martin1, G. R. Schlunck1,
H. Agostini1, D. Boehringer1, G. Pütz2, A. Stahl1.
1
Eye Center, Albert-Ludwigs-University Freiburg,
Freiburg, Germany; 2Department of Clinical
Chemistry, University Hospital Freiburg, Freiburg,
Germany *CR
3696 — D0107 Rapid evaluation of risk factors
linked to age-related macular degeneration
(AMD): STARS questionnaire. M Isabel Lopez7, 8,
A. Garcia-Layana3, 4, F. Gomez Ulla1, 6, J. RuizMoreno2, 7, M. S. Figueroa5, 6, J. Pastor8, 3. 1Instituto
Gomez Ulla, Santiago de Compostela, Spain;
2
Universidad de Castilla la Mancha, Albacete,
Spain; 3RETICS OFTARED, Madrid, Spain;
4
Clinica Universitaria de Navarra, Pamplona,
Spain; 5Hospital Ramón y Cajal, Madrid, Spain;
6
Fundación Retina Plus +, Santiago de Compostela,
Spain; 7Sociedad Española de Retina y Vitreo,
Santiago de Compostela, Spain; 8IOBA/HCUV,
Valladolid, Spain *CR
3697 — D0108 Detecting Macular
Degeneration with Diagnostic Retinoscopy.
Clinton N. Sims. Department of Ophthalmology and
Visual Sciences, University of Louisville,
Ft Myers, FL *CR
3698 — D0109 Expression of VEGF-A,
VEGF-C, VEGF-D and soluble receptors in
Clinical Age-Related Macular Degeneration.
Gianna C. Teague1, J. Ma1, W. Johnson2, M. E.
Baldwin3, K. Lashkari1.1Schepens Eye Research
Institute, Massachusetts Eye & Ear Infirmary,
Boston, MA; 2Department of Physics, Suffolk
University, Boston, MA; 3Circadian Technologies
Ltd, Opthea Pty Ltd, South Yarra, VIC, Australia
*CR
3699 — D0110 Incidence rate of massive
submacular hemorrhage and its risk factors in
polypoidal choroidal vasculopathy. Joon Hee
Cho, N. Ryoo, K. Cho, K. Park, S. Woo, S. Park.
Ophthalmology, Seoul National University Bundang
Hospital, Seongnam, Korea (the Republic of)
3700 — D0111 The reliability of rod and cone
sensitivity measurements using a novel darkadapted chromatic perimeter. Rose S. Tan1, 2, R.
H. Guymer1, 2, E. Caruso1, C. D. Luu1, 2. 1Centre for
Eye Research Australia, Melbourne, VIC, Australia;
2
Department of Surgery (Ophthalmology), The
University of Melbourne, Melbourne, VIC,
Australia
3701 — D0112 Practice patterns in agerelated macular degeneration (AMD). Angelica
Ly, L. Nivison-Smith, B. Zangerl, M. Kalloniatis.
Centre for Eye Health, SOVS, UNSW Australia,
Kensington, NSW, Australia
3702 — D0113 Perception of Haidinger’s
Brushes in Macular Disease Depends on Macular
Pigment Optical Density and Visual Acuity.
Philipp L. Mueller, S. Müller, M. Gliem, K. Küpper,
F. G. Holz, W. M. Harmening, P. Charbel Issa.
Department of Ophthalmology, University of Bonn,
Bonn, Germany *CR
3703 — D0114 One year results of intravitreal
aflibercept injection in the treatment of wet
age related macular degeneration. Awatif O.
Barakat, C. Ton Van, J. Hung, S. Bouakaz, T. Tran.
Ophthalmology, Lille Catholic Hospitals,
Lille, France
3704 — D0115 Intravitreal Autologous Bone
Marrow Derived Stem Cells in Dry Age-related
Macular Degeneration. Rubens C. Siqueira, C.
Costa Cotrim, A. Messias, M. V. Sousa, L. Toscano,
R. Jorge. Ophthalmology, Sao Paulo University, Sao
Jose do Rio Preto, Brazil f
3705 — D0116 New rapid digital dark
adaptometer that shows high sensitivity and
specificity for early AMD. Ian Murray, D. Carden,
J. M. Kelly. Faculty of Life Sciences, University of
Manchester, Manchester, United Kingdom *CR
3706 — D0117 Dark adaptation impairment
in patients with drusen. Miriam Garcia Planas1, 2,
M. Biarnes1, 2, J. Mones1, 2. 1Institut de la Macula,
Barcelona, Spain; 2Barcelona Macula Foundation,
Barcelona, Spain
3707 — D0118 Impact of optical coherence
tomography (OCT) on decision to continue
treatment for neovascuar age-related macular
degeneration. Cornelia Volz1, F. Grassmann2,
R. Greslechner1, D. A. Maerker1, P. Peters1, H.
Helbig1, M. Gamulescu1. 1University Eye Clinic,
University of Regensburg, Parsberg, Germany;
2
Institute of Human Genetics, University of
Regensburg, Regensburg, Germany
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
252
Tuesday – Posters – 3708 – 3723
3708 — D0119 Recurrence of neovascular
(wet) age-related macular degeneration (AMD)
in patients discharged from care in a real-world
clinical practice in the UK. fadi alfaqawi, S.
Elsherbiny, B. Mushtaq. Birmingham and Midland
Eye Centre, Birmingham, United Kingdom
3709 — D0120 Threshold versus Area
Assessment to Determine Aspects of Rod
Photoreceptor Loss in Subjects with AgeRelated Macular Degeneration (AMD). Tad
Daniels1, J. Felius1, 2, D. G. Birch1, 2, K. G. Csaky1, 2.
1
Retina Foundation of the Southwest, Dallas, TX;
2
Opthalmology, University of Texas Southwestern
Medical Center, Dallas, TX
3710 — D0121 Biofluids NMR metabolomics
in Age-related macular degeneration. Deeba
Husain1, I. Laines1, A. S. Martins2, D. Duarte2,
A. Barros2, R. M. Silva3, 4, A. Gil2, J. W. Miller1.
1
Ophthalmology, Mass eye and ear, Harvard
Medical School, Boston, MA; 2University of Aveiro,
CICECO - Aveiro Institute of Materials, Aveiro,
Portugal; 3Faculdadw de Medicina, Universidade
de Coimbra, Coimbra, Portugal; 4Association for
Innovation and Biomedical Research on Light,
Coimbra, Portugal *CR
3712 — D0123 Decreased Plasma Levels of
Dickkopf-1 in Patients with Exudative Agerelated Macular Degeneration. Zhen Liu1, F. Qiu1,
Y. Zhou1, J. He1, J. Ma2, Z. Liu1. 1medical college
of xiamen university, Eye Institute of Xiamen
University, Xiamen, China; 2Physiology, The
University of Oklahoma Health Sciences Center,
Oklahoma, OK
Exhibit/Poster Hall D0174-D0203
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Retina
347 Retinal Prosthesis and Stem Cells
3715 — D0176 Effect of stimulus pulse on
evoked potential amplitude in the superior
colliculus of rats by electrical stimulation with
Suprachoroidal-Transretinal Stimulation (STS)
retinal prosthesis. Yukari Nakano1, Y. Terasawa1, 2,
H. Kanda3, K. Osawa1, M. Ozawa4, T. Miyoshi5,
H. Sawai6. 1Research and Development Division,
Nidek Co., Ltd., Gamagori, Japan; 2Graduate School
of Materials Science, Nara Institute of Science
& Technology, Ikoma, Japan; 3Department of
Applied Visual Science, Osaka University Graduate
School of Medicine, Suita, Japan; 4Nidek Co.,
Ltd., Gamagori, Japan; 5Department of Integrative
Physiology, Osaka University Graduate School
of Medicine, Suita, Japan; 6Department of Health
Sciences, School of Nursing, Osaka Prefecture
University, Habikino, Japan *CR
3716 — D0177 Development of an alpha retinal
ganglion cell model for epiretinal electrode
stimulation. Ethan D. Cohen1, E. Neufeld2, H.
Montanaro2, M. I. Iacono1, L. M. Angelone1, W.
Kainz1. 1Div. Biomedical Physics, Office of Sci. and
Eng. Labs, Ctr. for Dev. & Rad. Health, FDA, Silver
Spring, MD; 2Computational Life Sciences, IT’IS
Research Foundation, Zurich, Switzerland
3717 — D0178 Electric stimulus duration
alters network-mediated responses depending
on retinal ganglion cell type. Maesoon Im1, 2, S.
I. Fried2, 3. 1Ophthalmology, Henry Ford Hospital,
Northville, MI;2Boston VA Healthcare System,
Boston, MA; 3Neurosurgery, Massachusetts General
Hospital/HMS, Boston, MA
3718 — D0179 Relative power consumption
at the electrode-retina interface during retinal
stimulation with voltage versus current
controlled stimulus pulses. Kiran Nimmagadda2, 3,
N. Davuluri4, J. D. Weiland1, 4. 1Ophthalmology,
USC, Los Angeles, CA; 2Neuroscience Graduate
Program, University of Southern California,
Los Angeles, CA; 3USC - Caltech MD/PhD
Program, Los Angeles, CA; 4Biomedical
Engineering, University of Southern California,
Los Angeles, CA
3719 — D0180 Surgical feasibility of widefield dual-array suprachoroidal-transretinal
stimulation (STS) prosthesis in middle-sized
animals. Takeshi Morimoto2, H. Kanda2, T.
Miyoshi3, T. Endo1, T. K. Lohmann4, 2, K. Nishida1, T.
Fujikado2. 1Ophthalmology, Osaka Univ Graduate
Sch of Med, Suita, Japan; 2Applied Visual Science,
Osaka University Graduate School of Medicine,
Suita, Japan; 3Integrative Physiology, Osaka
University Graduate School of Medicine, Suita,
Japan; 4Ophthatmology, Aachen RWTH Aachen
University, Aachen, Germany
3720 — D0181 Evaluation of the spatial
resolution of electrode arrays for suprachoroidal
retinal prosthesis by recording single-unit
activities in the lateral geniculate nucleus.
Hiroyuki Kanda1, T. Miyoshi2, T. Morimoto1,
T. Fujikado1. 1Applied Visual Science, Osaka
University Graduate School of Medicine, Suita,
Japan; 2Integrative Physiology, Osaka University
Graduate School of Medicine, Suita, Japan *CR
3721 — D0182 Spatio-temporal characteristics
of retinal responses to subretinal photovoltaic
stimulation. Richard Smith1, E. Ho2, G. A. Goetz2, 3,
X. Lei3, T. Kamins3, J. Harris3, K. Mathieson4,
D. V. Palanker2, 5, A. Sher1. 1Santa Cruz Institute
for Particle Physics, UC Santa Cruz, Santa Cruz,
CA; 2Hansen Experimental Physics Lab, Stanford,
Palo Alto, CA; 3Electrical Engineering, Stanford,
Palo Alto, CA; 4Institute of Photonics, University
of Strathclyde, Glasgow, United Kingdom;
5
Ophthalmology, Stanford, Palo Alto, CA *CR
3722 — D0183 Spatial aspects of electrical
desensitization in mouse retina. Archana
Jalligampala1, 2, E. Zrenner1, D. L. Rathbun1.
1
Institute for Ophthalmic Research & Center for
Integrative Neuroscience, University of Tuebingen,
Tuebingen, Germany; 2Graduate Training Center of
Neuroscience, University of Tuebingen, Tuebingen,
Germany *CR
3723 — D0184 Implications of low prosthetic
contrast sensitivity for delivery of visual
information. Georges A. Goetz1, 2, R. Smith3, X.
Lei4, L. Galambos4, T. Kamins4, K. Mathieson5, A.
Sher3, D. V. Palanker2, 6. 1Neurosurgery, Stanford
University, Stanford, CA; 2Hansen Experimental
Physics Laboratory, Stanford University, Stanford,
CA; 3Santa Cruz Institute for Particle Physics,
University of California Santa Cruz, Santa Cruz,
CA; 4Electrical Engineering, Stanford University,
Stanford, CA; 5Institute of Photonics, University
of Strathclyde, Glasgow, United Kingdom;
6
Ophthalmology, Stanford University, Stanford, CA
*CR
Moderators: Eyal Banin and Jose Sahel
3713 — D0174 Evaluation of electrical
stimulation of the retina with optical coherence
tomography. Alejandra Gonzalez Calle, J. D.
Weiland. Biomedical Engineering, University of
Southern California, Los Angeles, CA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
253
Tuesday Posters
11:00 am – 12:45 pm
3711 — D0122 Spectral Domain Optical
Coherence Tomography 2-Year Localized
Precursors to New Onset Geographic Atrophy
in Age-Related Macular Degeneration. Malini
Veerappan1, V. Tai1, S. Chiu1, K. Winter1, A.
El-Hage-Sleiman1, E. Lad1, C. Harrington1, R.
Gunther1, W. T. Wong3, E. Y. Chew3, C. A. Toth1, 2.
1
Duke Eye Center, Duke University Medical
Center, Durham, NC; 2Department of Biomedical
Engineering, Duke University, Durham, NC;
3
National Eye Institute, National Institutes of
Health, Bethesda, MD *CR, f
3714 — D0175 Focal electrical stimulation of
the retina. Andrew C. Weitz1, 2, D. Nanduri2, R.
J. Greenberg3, M. S. Humayun1, 2, R. H. Chow4, 2,
J. D. Weiland1, 2. 1Ophthalmology, University of
Southern California, Los Angeles, CA; 2Biomedical
Engineering, University of Southern California,
Los Angeles, CA; 3Second Sight Medical Products,
Inc., Sylmar, CA; 4Physiology & Biophysics,
University of Southern California, Los Angeles, CA
*CR, f
3725 – 3742 – Tuesday – Posters
3725 — D0186 Apoptosis reduction by a
photoelectric dye used for Okayama Universitytype retinal prosthesis (OURePTM). Shihui Liu1, T.
Matsuo1, O. Hosoya2, T. Uchida3. 1Ophthalmology,
Okayama University Graduate School of Medicine,
Dentistry, and Pharmaceutical Sciences, Okayama,
Japan; 2Neurogenomics, Okayama University
Graduate School of Medicine, Dentistry, and
Pharmaceutical Sciences, Okayama, Japan;3Polymer
Materials Science, Okayama University Graduate
School of Natural Science and Technology,
Okayama, Japan
Tuesday Posters
11:00 am – 12:45 pm
3726 — D0187 Retinal safety of near infrared
radiation in photovoltaic restoration of sight.
Henri Lorach1, 2, J. Wang1, 2, D. Lee1, 3, R. Dalal1,
P. Huie3, D. V. Palanker1, 2. 1Ophthalmology,
Stanford University, Stanford, CA; 2HEPL, Stanford
University, Stanford, CA; 3Ophthalmology, Gachon
University, Incheon, Korea (the Republic of) *CR
3727 — D0188 Fabrication and in-vitro
characterization of novel hydrogel-based
electrodes for visual prostheses. Yasuo
Terasawa1, 3, H. Tashiro2, Y. Nakano1, K. Osawa1,
M. Ozawa4, T. Noda3, T. Tokuda3, J. Ohta3, K.
Haraguchi5. 1Vision Institute, R&D Div, NIDEK
Co Ltd, Gamagori, Japan; 2Department of Health
Sciences, Faculty of Medical Sciences, Kyushu
University, Fukuoka, Japan; 3Materials Science,
Nara Institute of Science and Technology, Ikoma,
Japan; 4Nidek Co.,Ltd., Gamagori, Japan; 5College
of Industrial Technology, Nihon University,
Narashino, Japan *CR
3728 — D0189 Focal activation of retinal
ganglion cells with epiretinal implants: The
AIS as a key component. Paul Werginz1, A.
Hadjinicolaou2, 3, S. I. Fried2, 3, F. Rattay1. 1Institute
for Analysis and Scientific Computing, Vienna
University of Technology, Vienna, Austria; 2Vision
Research Laboratory, Boston VA Medical Center,
Boston, MA; 3Department of Neurosurgery,
Massachusetts General Hospital & Harvard Medical
School, Boston, MA
3729 — D0190 Extraction of directly-evoked
Retinal Ganglion Cell response from stimulus
artifact using three artifact subtraction
algorithms. Jungryul Ahn1, M. Choi2, D. Park1, K.
Koo2, Y. Goo1.1Department of Physiology, School
of Medicine, Chungbuk National University,
Cheong-ju, Korea (the Republic of); 2Department
of Biomedical Engineering, University of Ulsan,
Ulsan, Korea (the Republic of)
3730 — D0191 Oscillatory Rhythm in
Degenerate Mouse (rd10) Retina Modulates
Retinal Ganglion Cell Response to Electrical
Stimulus. Dae-jin Park1, J. Ahn1, S. Cha1, Y. Goo1,
S. Senok2. 1Department of Physiology, School
of Medicine, Chungbuk National University,
Cheongju, Korea (the Republic of); 2Neuroscience,
College of Medicine, Alfaisal University, Riyadh,
Saudi Arabia
3731 — D0192 Towards an improvement of
the visual function preservation in RCS rats
by transplantation of human stem-cell-derived
RPE and photoreceptor precursor cells. Laura
Fontrodona1, L. Miquel2, Y. Muñoz2, D. Mora
Ramírez1, A. Salas Torras1, B. Ferreira-de-Souza1,
M. Riera1, S. Albert2, A. Veiga2, J. Garcia-Arumi1.
1
Ophthalmology, Vall d’Hebron Research Institute
(VHIR), Barcelona, Spain; 2Stem Cell Bank, Center
of Regenerative Medicine in Barcelona (CMRB),
Barcelona, Spain
3732 — D0193 Acute Synaptic and Neuronal
Anatomical Changes Following Insertion of
Sub-Retinal Electrode Array in an Enucleated
Human Eye. Jinghua Chen1, G. DeWalt2, W.
Eldred2, M. Gingerich3, D. Shire3, J. F. Rizzo4,
H. J. Kaplan1. 1Ophthalmology and Visual
Sciences, University of Louisville, Louisville, KY;
2
Department of Biology, Boston University, Boston,
MA; 3Bionic Eye Technologies, Inc., Fishkill,
NY;4Ophthalmology, Harvard Medical School,
Boston, MA *CR
3733 — D0194 ARGUS II® Electronic
Epiretinal Prosthesis In Advanced Dry Amd:
Safety And Feasibility Study And Preliminary
Functional Results. Paulo E. Stanga1, 2, A. Jalil1,
E. TSAMIS1, 2, A. Papayannis1, J. D. Dorn3, R.
J. Greenberg3, W. Mcguire3. 1Manchester Vision
Regeneration (MVR) Lab at Manchester Royal
Eye Hospital & NIHR/Wellcome Trust Manchester
CRF and Manchester Royal Eye Hospital, Central
Manchester University Hospitals NHS Foundation
Trust, Manchester, United Kingdom; 2Institute
of Human Development, Faculty of Medical
and Human Sciences, University of Manchester,
Manchester, United Kingdom; 3Second Sight
Medical Products, Inc, Sylmar, CA *CR, f
3734 — D0195 Local and systemic immune
responses associated with rejection of iPSderived RPE allografts transplanted into rhesus
macaques. Trevor J. McGill1, 2, J. W. Stoddard2, L.
M. Renner2, R. Bonnah2, E. Johnson2, I. Messaoudi3,
S. T. Bailey1, A. Lauer1, S. Mitalipov3, D. J. Wilson1,
M. Neuringer2, 1. 1Ophthalmology, Casey Eye
Institute, OHSU, Portland, OR; 2Neuroscience,
Oregon National Primate Research Center,
Beaverton, OR; 3Oregon National Primate Research
Center, Beaverton, OR
3735 — D0196 A New Immunodeficient
Dystrophic RCS Rat Model for Transplantation
Studies Using Human Derived Cells. Biju
Thomas2, C. H. Shih2, D. Zhu1, J. C. Martinez2,
D. R. Hinton2, 1, M. S. Humayun2. 1Pathology,
University of Southern California Keck School
of Medicine, Los Angeles, CA; 2Ophthalmology,
University of Southern California Keck School of
Medicine, Los Angeles, CA
3736 — D0197 Dissociation protocol and
optimal conditions for clinical-grade induced
pluripotent stem cell-derived retinal precursor
cells. Brittni Scruggs, B. A. Tucker, C. Jiao, J.
Riley, E. M. Stone, R. F. Mullins, E. H. Sohn. Wynn
Institute for Vision Research, University of Iowa,
Iowa City, IA *CR
3737 — D0198 Human retinal progenitor
sheet transplants in immunodeficient retinal
degenerate (RD) rats. Magdalene J. Seiler1, 2, B. T.
McLelland2, A. Mathur2, R. lin2, D. T. Alexander2,
P. N. Patel2, B. Cummings1, 2, R. B. Aramant2.
1
Physical Medicine & Rehabilitation, University
of California, Irvine, Irvine, CA; 2Sue & Bill
Gross Stem Cell Research Center, University of
California, Irvine, Irvine, CA *CR
3738 — D0199 Optimizing subretinal injection
conditions for retinal gene and stem cell therapy.
Elliott H. Sohn, C. Jiao, B. Scruggs, D. Brack, E.
M. Stone, R. F. Mullins, B. A. Tucker. University of
Iowa Dept of Ophthalmology, Wynn Institute for
Vision Research, Iowa City, IA *CR
3739 — D0200 Optimizing a Biodegradable
Scaffold for Clinical Applications of iPS Cell
Derived RPE Tissue. Vladimir Khristov, N.
Hotaling, Y. Li, H. Qian, Q. Wan, R. Sharma, A.
Maminishkis, J. Amaral, S. S. Miller, J. Davis, K.
Bharti. National Eye Institute, Bethesda, MD
3740 — D0201 Survivability And Surface
Coverage Of Human Retinal Pigment
Epithelium (Rpe) On Aged Human Bruch’s
Membrane (Bm) Can Be Restored Using
Patch Grafts Of Young BM. Qun Zeng1, A. Del
Priore1, A. Hondur1, L. V. Del Priore2, T. H. Tezel1.
1
Department of Ophthalmology, The Edward
Harkness Eye Institute, Columbia University,
College of Physicians and Surgeons, New York,
NY; 2Department of Ophthalmology, Storm Eye
Institute, Medical University of South Carolina,
Charleston, SC
3741 — D0202 Intravitreal Autologous
Bone Marrow Derived Stem Cells in Ischemic
Maculopathy Results after 12 Months Followup. Felipe P. Borges, R. C. Siqueira, M. W.
Rodrigues, A. J. Dos Santos, A. Messias, R. Jorge.
Ophthalmology, University of Sao Paulo, Ribeirao
Preto, Brazil f
3742 — D0203 Clincal trial: subretinal
transplantation of CTS hESC derived RPE
in the treatment of wet Age-related Macular
Degeneration (wAMD). Zheng Qin Yin1, Y. Liu1,
S. Li1, H. Xu1, Y. Wang1, C. Qian2, Q. Zhou3.
1
Ophthalmology, Southwest Hospital, Third Military
Medical University, Chongqing, China; 2Southwest
Hospital,Third Military Medical University,
Chongqing, China; 3Institute of zoology,Chinese
Acadamy of Sciences, Beijing, China f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
254
Tuesday – Posters – 3743 – 3758
Exhibit/Poster Hall D0235-D0250
Tuesday, May 03, 2016 11:00 AM-12:45 PM
Multidisciplinary Ophthalmic Imaging Group /
Anatomy and Pathology/Oncology
348 Functional Imaging
Moderators: Xincheng Yao and Ravi S. Jonnal
3743 — D0235 Hyperspectral Measurement
of Retinal Oximetry in Diabetes. Joel Kaluzny2,
H. Li1, P. L. Nesper2, W. Liu1, H. F. Zhang2, A.
Fawzi2. 1Department of Biomedical Engineering,
Northwestern University, Evanston, IL;
2
Department of Ophthalmology, Northwestern
University, Chicago, IL
3744 — D0236 Hyperspectral snapshot camera
for functional imaging of the retina. Jason
Dwight1, R. Coffee2, M. E. Pawlowski1, C. Y. Weng2,
T. Tkaczyk1. 1Bioengineering, Rice University,
Houston, TX;2Ophthalmology, Baylor College of
Medicine, Houston, TX
3746 — D0238 Normal limits of retinal
oximetry and retinal venous oxygen saturation
in atrophic diseases. Olof B. Olafsdottir1, 3, S. H.
Hardarson1, 3, E. Vandewalle2, T. Eysteinsson1, 3,
M. S. Gottfredsdottir3, K. Van Keer2, L. Abegao
Pinto4, I. Stalmans2, E. Stefansson3, 1. 1University of
Iceland, Reykjavik, Iceland; 2University Hospitals
Leuven, Leuven, Belgium; 3Landspitali University
Hospital, Reykjavik, Iceland;4Centro Hospitalar de
Lisboa Central, Lisbon, Portugal *CR
3747 — D0239 Comparison of different
imaging protocols used in retinal vessel oximetry.
Rebekka Heitmar. Optometry & Vision Sciences,
Aston University, Birmingham, United Kingdom
3748 — D0240 Automatic quantitative
oximetry analysis in smaller retinal microvessels acquired by the retinal function imager,
RFI, non-invasively. Sagi -. Reuven1, 2, R. Wilf4,
F. -. Rotbart1, J. Wang5, D. DeBuc5, A. Mohan6, A.
Grinvald3. 1Optical Imaging Ltd, Rehovot, Israel;
2
IDC Hertzelia, Herzelia, Israel; 3Neurobiology,
Weizmann Institute of Science, Rehovot, Israel;
4
Optical Imaging, Rehovot, Israel; 5Bascom Palmer
Eye Institute, Miami, FL; 6Narayana Nethralaya,
Bangalore, India *CR
3751 — D0243 Impact of oral contranceptive
pill (OCP) on vessels functionality. Alessandro
Rabiolo, F. Corvi, D. Monteduro, L. Benatti, G.
Querques, F. Bandello. Ophthalmology, IRCCS,
Vita-Salute San Raffaele University, Milan, Italy
*CR
3752 — D0244 Multi-modal optical
coherence tomography enables concurrent
imaging of retinal neural activity and vascular
hemodynamics. Taeyoon Son1, B. Wang1, D.
Thapa1, Y. Lu1, D. Cao2, X. Yao1, 2. 1Department of
Bioengineering, University of Illinois at Chicago,
Chicago, IL; 2Department of Ophthalmology and
Visual Sciences, University of Illinois at Chicago,
Chicago, IL *CR
3757 — D0249 fMRI Studies: Calpain
Inhibitor SNJ-1945 Ameliorates Dysfunction in
Injured Rat RGCs. Takayuki Oka1, C. Yabuta1,
T. R. Shearer2, M. Azuma1, 2. 1Senju Laboratories
of Ocular Sciences, Senju Pharmaceutilal Co
Ltd, Kobe, Japan; 2Department of Integrative
Biosciences, Oregon Health & Science University,
Portland, OR *CR
3758 — D0250 Visualizing retina signal
transduction with dual beam electron imaging.
Holland Cheng1, L. Xing1, H. Wang1, R. Luo2, J.
Shyue2, P. G. FitzGerald1, K. Lam1. 1University of
California, Davis, CA;2NanoLab, Milpitas, CA
3753 — D0245 Retinotopic Mapping After
Bilateral Implantation Of A Multifocal
Diffractive IOL. José F. Costa1, A. C. Rosa1, 2,
Â. Miranda3, C. F. Lobo1, 2, F. Silva4, M. CasteloBranco2, 4, J. N. Murta1, 2. 1Ophthalmology, Centro
Hospitalar e Universitário de Coimbra, Coimbra,
Portugal; 2Faculdade de Medicina da Universidade
de Coimbra, Coimbra, Portugal; 3ICNAS - Institute
for Nuclear Sciences Applied to Health, Coimbra,
Portugal; 4IBILI - Institute for Biomedical Imaging
and Life Sciences, Coimbra, Portugal
3754 — D0246 Functional Evaluation of
Subretinal Space iPSC-RPE Implant In a LaserInduced RPE Injury Model In Pig. Yichao Li, J.
Amaral, R. Zhou, A. Maminishkis, S. S. Miller, H.
Qian, K. Bharti. National Eye Institute, Rockville, MD
3755 — D0247 Development of a custom
imaging system for simultaneous monitoring
of retinal and cortical physiology. Yusi Liu1, Q.
Wang2, A. Rege1, S. Cunningham1, K. Raje1, H.
Modi2, N. Thakor2, I. E. Zimmer-Galler3, P. L.
Gehlbach3. 1Vasoptic Medical Inc., Baltimore, MD;
2
Department of Biomedical Engineering, the Johns
Hopkins University, Baltimore, MD; 3The Wilmer
Eye Institute, Johns Hopkins University School of
Medicine, Baltimore, MD *CR
3756 — D0248 Functional magnetic
resonance imaging as an innovative tool to
assess neuroadaptation after cataract surgery.
Andreia M. Rosa1, 2, Â. Miranda2, J. F. Costa1,
E. A. Almeida1, F. Silva2, M. Castelo-Branco2, J.
N. Murta1, 2. 1Ophthalmology, Centro Hospitalar
e Universitário de Coimbra, Coimbra, Portugal;
2
IBILI, Faculty of Medicine, Coimbra, Portugal
3749 — D0241 Temporal dynamics of inner
retinal vasculature and oxygen extraction
fraction during light flicker stimulation in
humans. Anthony E. Felder, N. P. Blair, M. Shahidi.
Ophthalmology & Visual Sciences, University of
Illinois at Chicago, Chicago, IL
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
255
Tuesday Posters
11:00 am – 12:45 pm
3745 — D0237 Abnormal retinal venous
oxygen saturation in retinal vascular disease.
Sveinn H. Hardarson1, 2, T. Bek3, T. S. Eliasdottir1, 2,
E. Stefansson1, 2. 1University of Iceland, Reykjavik,
Iceland;2Ophthalmology, Landspitali, Reykjavik,
Iceland; 3Department of Ophthalmology, Aarhus
University Hospital, Aarhus, Denmark *CR
3750 — D0242 Alterations in retinal tissue
oxygen tension due to light flicker stimulation
in rat. Norman P. Blair, M. R. Tan, A. E. Felder,
P. Teng, J. Wanek, M. Shahidi. Ophthalmology
and Visual Sciences, Univ of Illinois at Chicago,
Chicago, IL *CR
Tuesday – Workshops/SIGs
Room 615/617
Room 606/607
Room 608
Tuesday, May 03, 2016 1:00 PM-2:30 PM
Tuesday, May 03, 2016 1:00 PM-2:30 PM
Tuesday, May 03, 2016 1:00 PM-2:30 PM
Multidisciplinary Ophthalmic Imaging Group
350 Making a difference - how you can
advocate your research to patients and
the public using social media as an
effective outreach tool
351 Identifying Your Career Options
using MyIDP, ScienceCareers.org,
LinkedIn & More
349 MOI Group - Intra-operative OCT
The utility of intra-operative OCT has been
demonstrated in both clinical and research studies
for assisting ophthalmic surgical procedures. This is
a rapidly evolving technology that has a significant
impact on ophthalmic surgery. This MOI session
provides the most updated information regarding
intra-operative OCT and discusses the current
limitations and future directions.
Moderators: Joseph A. Izatt, Justis P. Ehlers
and Zhuolin Liu
— 1:00 Opening Remarks
— 1:03 Integrative Advances for
Intraoperative OCT Guided Ophthalmic
Surgery. Yuankai Tao. Cleveland Clinic,
Cleveland, OH
Tuesday Workshops/SIGs
1:00 pm – 2:30 pm
— 1:20 The future of ophthalmic
microsurgery--guided by 4D OCT. Cynthia
A. Toth. Duke Univ Eye Center, Durham, NC;
Biomedical Engineering, Duke University, Durham,
NC *CR, f
— 1:37 Microscope-Integrated Image-Guided
Ophthalmic Surgery: Clinical Evidence and New
Paradigms. Justis P. Ehlers. Cleveland Clinic,
Cleveland, OH *CR, f
— 1:54 Future directions in intra-operative
OCT development. Joseph A. Izatt. Duke
University, Durham, NC *CR
— 2:11 In-Situ Intraoperative OCT: Natural
visual and haptic interaction with the otherwise
imperceptible. John Galeotti. Robotics Institute,
Carnegie Mellon University, Pittsburgh, PA;
Bioengineering, University of Pittsburgh,
Pittsburgh, PA *CR
Communicating the importance of our vision
research to the wider community is vital. Patients
want to understand our latest research and find
out what it might mean for them, law makers
and regulators want to know what is important to
people, and we want funders to continue to support
our research efforts. Social media is an effective
outreach tool available to many people in all walks
of life. During this workshop we will explore how
we could all use social media more, e.g. Twitter, to
raise the profile of our vision research.
Moderators: Juliet A. Moncaster and
Julie T. Daniels
— 1:00 Why advocacy is important: Research
changes lives. Peng T. Khaw. NIHR Biomedical
Research Centre, Moorfields Eye Hospital &
UCL Institute of Ophthalmology, London, United
Kingdom
— 1:20 Advocacy group perspective. Michael
Buckley. Brightfocus Foundation, USA, Clarksburg,
MD
— 1:40 Advocacy workshop Using social
media to promote vision research. Steven M.
Christiansen. Ophthalmology and Visual Sciences,
University of Iowa, Iowa City, IA
— 2:00 Seeing Social Clearly: How Social
Media Can Be a Top Ally in Advocacy and
Outreach. Heather Fernandez. Fearey Group,
Seattle, WA
— 2:28 Closing Remark
This workshop will empower trainees to identify
core skills, create career awareness and build
competence in identifying career opportunities
and developing strategies when searching for jobs.
Members-in-training will identify their transferable
knowledge and skills and practice communicating
this to others. The workshop will be followed by
four hours of one-on-one counseling sessions (1520 minutes each) to interested trainees. Together,
the workshop and the 1-on-1 sessions will provide
basic science and clinical trainees with structure
and resources for exploring career paths. Sign-up
for a one-on-one counseling session during the
workshop.
Moderators: Peter F. Hitchcock, Michael H. Elliott
and Esther M. Bowie
— 1:00 Looking Beyond Academia: Identifying
Your Options using MyIDP, ScienceCareers.org,
LinkedIn & More. Andrew Green. Career Center,
UC Berkeley, Berkeley, CA
Room 611/612
Tuesday, May 03, 2016 1:00 PM-2:30 PM
352 NIH-CSR Workshop on the Review
of Grant Applications
Sponsored by the Center for Scientific Review
(CSR) at the National Institutes of Health (NIH)
this workshop is designed to inform grant applicants
about the NIH peer review process and also provide
information about the study sections that review
visual system grant applications. Scientific Review
Officers (SROs) from CSR will be present for the
presentation and to answer any questions.
— 1:00 Introduction. Michael Chaitin. National
Institutes of Health, Bethesda, MD
— 1:45 Panelist. Nataliya Gordiyenko. Center
for Scientific Review, National Institutes of Health,
Bethesda, MD
— 2:00 Panelist. Paek-Gyu Lee. Ophthalmology,
Center for Scientific Review/NIH, Bethesda, MD
— 2:15 Panelist. Maqsood A. Wani. Center for
Scientific Review, National Institutes of Health,
Bethesda, MD
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
256
Tuesday – Workshops/SIGs
Room 6A
Tuesday, May 03, 2016 1:00 PM-2:30 PM
Retina / Clinical/Epidemiologic Research /
Immunology/Microbiology / Physiology/
Pharmacology / Visual Neuroscience
353 Managing Patients with Diabetic
Macular Edema, Neovascular AMD,
and Retinal Vein Occlusion: How to
Best Utilize Data from Clinical Trials
- SIG
The SIG will provide a forum for interpretation of
significance of data and discussion on how results
will be translated into clinical practice. There will
be no rehash of data presented elsewhere at ARVO.
Audience participation will be encouraged.
Moderators: Peter A. Campochiaro and
Diana V. Do
What Is a Desired Endpoint in the Management
of DME ? Quan Dong Nguyen. Truhlsen Eye
Institute, University of Nebraska Medical Center,
Omaha, NE *CR
Which anti-VEGF Agent Do You Use and Why?
What is the Role of Corticosteroids in the
Mangement of DME? Robert L. Avery. California
Retina Consultants, Santa Barbara, CA *CR
What Is the Role of Wide-angle Retinal Imaging
in the Management of Vaso-Occlusive Diseases?
David S. Boyer. Retina-Vitreous Associates Medical
Group, Beverly Hills, CA *CR
Room Skagit 4/5, TCC
Tuesday, May 03, 2016 1:00 PM-2:30 PM
Clinical/Epidemiologic Research / Glaucoma /
Retina
354 Big Data and Data Visualization
- Novel insights into retina disorders,
glaucoma and cataract - SIG
The approach to obtaining, analysing healthcare
datasets will be discussed from the perspective
of different countries and in different areas in
ophthalmology. How data visualisation can provide
novel insights beyond outcome metrics will be
shown.
Panelist. Anne L. Coleman. Jules Stein Eye Institue,
Los Angeles, CA
Room Tahoma 3, TCC
Tuesday, May 03, 2016 1:00 PM-2:30 PM
Panelist. Haogang Zhu. Insitiute of Ophthalmology,
UCL, London, United Kingdom *CR
Nanotechnology and Regenerative Medicine
Group / Anatomy and Pathology/Oncology /
Clinical/Epidemiologic Research / Retinal Cell
Biology / Retina / Visual Neuroscience
Room Tahoma 1/2, TCC
356 Integration in stem cell therapy -a
challenge and a hope for vision - SIG
Tuesday, May 03, 2016 1:00 PM-2:30 PM
Cornea / Anatomy and Pathology/Oncology /
Biochemistry/Molecular Biology / Clinical/
Epidemiologic Research / Cornea / Genetics /
Glaucoma / Lens
355 Applications of Genome Editing
Techniques in Biology of Anterior
Segment - SIG
We will explore the potentials of somatic editing
techniques, e.g., CRISPR, etc. for both in vivo
and in vitro experimental models for studying
pathogenesis and treatment regimens of congenital
and acquired anterior segment diseases.
Moderators: Winston W. Kao, Kohji Nishida and
Ting Xie
Somatic Gene Therapy of Mucopolysaccharidosis
with CRISPR/Cas9 Genome Editing. Winston
W. Kao. Ophthalmology, University of Cincinnati,
Cincinnati, OH
Stem cell therapy offers hope for blinding diseases.
This SIG will cover basic science and clincial trail
of stem cell therapy for RPE, photoreceptor, and
retinal ganglion cell repair, with a focus on the issue
of integration of transplanted cells.
Moderators: David M. Gamm and Wei Li
Organizer and panelist. Zheng Qin Yin.
Ophthalmology, Southwest Hospital, Third Military
Medical University, Chongqing, China
Panelist. Jeffrey L. Goldberg. Byers Eye Institute at
Stanford University, Palo Alto, CA
Panelist. Michael J. Young. 1Schepens Eye
Research Institute, Massachusetts Eye and Ear,
Boston, MA, 2Ocular Regenerative Medicine
Institute, Harvard Medical School, Boston, MA
Panelist. Jeffrey Stern. Neural Stem Cell Institute,
Rensselaer, NY
Panelist. Nishida. Ophthalmology, Osaka
University, Osaka, Japan
Panelist. Ting Xie. The Stowers Institute for
Medical Research, Kansas City, MO
Novel mouse models delivered by the CRISPR
Express. Yueh-Chiang Hu. Developmental Biology,
Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
Gene knock-in and Gene knock-out in iPS
cells and primary corneal epithelial cells
with CRISPR-Cas9 system. Koji Kitazawa.
Ophtalmology, Kyoto Prefecture Medical
University, Keoto, Japan
Use of genome editing to label lineagespecific transcription factors during corneal
embryogenesis in vitro. Satoshi Kawasaki.
Ophthalmology, Osaka University, Osaka, Japan
Moderators: Adnan Tufail and Mark C. Gillies
Panelist. Aaron Y. Lee. University of Washington,
Seattle, WA
Panelist. David Crabb. City University, London,
United Kingdom *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
257
Tuesday Workshops/SIGs
1:00 pm – 2:30 pm
Do Frequent Injections of Anti-VEGF Agents
Cause GA? Philip J. Rosenfeld. Bascom Palmer
Eye Institute, University of Miami, Miami, FL *CR
Panelist. Vincent Daien. Université de Montpellier,
Montpellier, France
Tuesday – All Posters
Exhibit/Poster Hall
Tuesday, May 03, 2016 2:45 PM-3:45 PM
359 All Posters / Networking
All Posters
2:45 pm – 3:45 pm
All presenters will be at their posters.
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
258
Tuesday – Papers/Minisymposium – 3759 – 3770
Room 6A
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Glaucoma
360 Glaucoma Imaging I
Moderators: Gadi Wollstein and Malik Y. Kahook
3759 — 3:45 Longitudinal reproducibility of
spectral domain optical coherence tomography
(SD-OCT) in children with stable glaucoma
and physiological cupping. Limin Xu2, M. ElDairi1, 4, E. Silverstein5, S. Freedman1, 3. 1Pediatric
Ophthalmology, Duke Eye Center, Durham, NC;
2
Duke University School of Medicine, Durham,
NC; 3Glaucoma, Duke Eye Center, Durham, NC;
4
Neuro-Ophthalmology, Duke Eye Center, Durham,
NC; 5Department of Ophthalmology, Virginia
Commonwealth University, Richmond, VA *CR
3760 — 4:00 Reference planes for measuring
of lamina cribrosa depth with optical
coherence tomography. Jayme R. Vianna, V. M.
Danthurebandara, G. P. Sharpe, D. Hutchison, A.
Belliveau, L. Shuba, M. T. Nicolela, B. C. Chauhan.
Glaucoma, Dalhousie University, Halifax, NS,
Canada *CR
3762 — 4:30 Diagnostic Innovations in
Glaucoma Study (DIGS): OCT Angiography
Vessel Density in Glaucomatous Eyes with Focal
Lamina Cribrosa Defects. Min Hee Suh1, 2, L.
M. Zangwill1, A. Belghith1, A. Yarmohammadi1, P.
C. Manalastas1, A. Diniz-Filho1, N. Fatehee1, S.
Yousefi1, R. N. Weinreb1. 1Ophthalmology, Hamilton
Glaucoma Center, Shiley Eye Institute, University
of California, San Diego, San Diego, CA;
2
Ophthalmology, Inje University Haeundae Paik
Hospital, Busan, Korea (the Republic of) *CR, f
3764 — 5:00 Impact of lamina cribrosa (LC)
and optic nerve head (ONH) surface deformation
on visual field (VF) progression in glaucoma: A
5-year prospective study. Christopher K. Leung,
Z. Wu, L. Chen. School of Medicine, The Chinese
University of Hong Kong, Hong Kong, Hong Kong
*CR
3765 — 5:15 Mitochondrial Flavoprotein
Fluorescence in Glaucoma Suspects, Primary
Open-Angle Glaucoma, and Healthy Controls.
Lawrence Geyman1, 2, A. Pinhas3, 1, B. Krawitz1, 2,
S. Mo1, 2, M. Field4, R. B. Rosen1. 1New York Eye
and Ear Infirmary of Mount Sinai, New York,
NY; 2Icahn School of Medicine at Mount Sinai,
New York, NY; 3North Shore-LIJ Health System,
Manhasset, NY; 4University of Michigan,
Ann Arbor, MI *CR
Room 6B
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Retina
361 Retinal Stem Cells and
Transplantation
Moderator: David M. Gamm
3766 — 3:45 Generation of retinal
photoreceptors from cGMP-Manufactured
Human IPSC line. Jie Zhu, H. Cifuentes, J.
Reynolds, D. A. Lamba. Ophthalmology, Buck
Institute for Research on Aging, Novato, CA
3767 — 4:00 A novel biosynthetic RPEBrM (Retinal Pigment Epithelium-Bruch’s
Membrane) assembly suitable for retinal
transplantation therapy. Andrew J. Lotery1, 6, G.
Ward1, 2, P. Alexander1, D. Johnston3, A. Page3,
A. J. Cree1, A. Bhaskar4, S. Mahajan5, 2, M.
Grossel2, J. Ratnayaka1. 1Clinical Neurosciences,
University of Southampton, Southampton,
United Kingdom; 2Department of Chemistry,
University of Southampton, Southampton, United
Kingdom; 3Biomedical Imaging Unit, University
of Southampton, Southampton, United Kingdom;
4
Faculty of Engineering and the Environment,
University of Southampton, Southampton, United
Kingdom; 5Institute for Life Sciences, University
of Southampton, Southampton, United Kingdom;
6
Southampton Eye Unit, University Hospital
Southampton NHS Foundation Trust, Southampton,
United Kingdom
3768 — 4:15 Phase I/II clinical trial of human
embryonic stem cell (hESC)-derived retinal
pigmented epithelium (RPE) transplantation
in Stargardt disease (STGD): One-year results.
Manjit S. Mehat. UCL Institute of Ophthalmology,
London, United Kingdom; NIHR Moorfields
Biomedical Research Centre, London,
United Kingdom f
3769 — 4:30 Transplantation of Autologous
induced Pluripotent Stem Cell-Derived Retinal
Pigment Epithelium Cell Sheets for Exudative
Age Related Macular Degeneration : A Pilot
Clinical Study.Yasuo Kurimoto1, 2, Y. Hirami1, 2, M.
Fujihara1, 2, C. Morinaga3, 1, M. Yamamoto1, 2, K.
Fujita4, S. Sugita3, 1, M. Mandai3, 1, M. Takahashi3, 1.
1
Ophthalmology, Institute for Biomedical Research
and Innovation Hospital, Kobe, Japan;
2
Ophthalmology, Kobe City Medical Ctr Gen Hosp,
Kobe, Japan; 3Laboratory for Retinal Regeneration,
RIKEN Center for Developmental Biology,
Kobe, Japan; 4Clinical Support Unit, Institute for
Biomedical Research and Innovation Hospital,
Kobe, Japan f
3770 — 4:45 Studies of Structure and
Function in Whole Eye Transplantation. Kia M.
Washington1, 2, Y. Li3, C. Komatsu1, M. R. Miller1, 4,
Y. van der Merwe4, 5, G. Wollstein4, 5, V. L. Fu4,
V. S. Gorantla1, K. C. Chan4, 5, J. S. Schuman4, 5.
1
Department of Plastic Surgery, University of
Pittsburgh, Pittsburgh, PA; 2VA Pittsburgh
Healthcare System, Pittsburgh, PA; 3Department of
Plastic and Reconstructive Surgery, Xijing Hospital,
Fourth Military Medical University, Xi’an, China;
4
Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 5Department of
Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, PA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
259
Tuesday Papers
Minisymposium
3:45 pm – 5:30 pm
3761 — 4:15 Lamina cribrosa pore tortuosity
in healthy and glaucomatous eyes. Bo Wang1, 2,
K. Lucy1, J. S. Schuman1, 2, I. A. Sigal1, 2, R.
A. Bilonick1, 3, C. D. Lu4, H. Ishikawa1, 2, L.
Kagemann1, 2, J. G. Fujimoto4, G. Wollstein1, 2.
1
UPMC Eye Center, Eye and Ear Institute,
Department of Ophthalmology, University of
Pittsburgh School of Medicine, Pittsburgh, PA;
2
Department of Bioengineering, Swanson School of
Engineering, University of Pittsburgh, Pittsburgh,
PA; 3Department of Biostatistics, University of
Pittsburgh School of Public Health, Pittsburgh,
PA; 4Department of Electrical Engineering and
Computer Science, Massachusetts Institute of
Technology, Cambridge, MA *CR
3763 — 4:45 Swept-Source OCT Optic Nerve
Head Structural Features of Primary Open
Angle Glaucoma and Disc Hemorrhage. Sophie
Cai1, M. K. Shoji1, E. Taniguchi1, D. Li1, L. A.
Pereira1, 2, S. C. Brauner1, S. H. Greenstein1,
A. Turalba1, L. R. Pasquale1, 3, L. Shen1.
1
Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA; 2Ministry of Education
of Brazil, CAPES Foundation, Brasilia, Brazil;
3
Channing Division of Network Medicine, Brigham
and Women’s Hospital, Boston, MA
3771 – 3786 – Tuesday – Papers/Minisymposium
Room 6C
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Retina
362 AMD Imaging
Moderators: Pearse A. Keane and
Robyn H. Guymer
Tuesday Papers/
Minisymposium
3:45 pm – 5:30 pm
3771 — 3:45 Peripheral Retinal Abnormalities
Associated with Age-Related Macular
Degeneration in the Age-Related Eye Diseases
Study 2 (AREDS2). Thomas R. Friberg1, A.
Domalpally2, R. Danis2, T. E. Clemons3, S. R.
Sadda4, C. A. Toth5, E. Y. Chew6. 1Ophthalmology
and BioEngineering, Univ of Pittsburgh, Pittsburgh,
PA; 2Reading Center, Univ of Wisconsin, Madison,
WI; 3Emmes Corporation, Bethesda, MD; 4Doheny,
Los Angeles, CA; 5Duke Eye Center, Durham, NC;
6
National Eye Institute, Bethesda, MD *CR, f
3772 — 4:00 Evaluation of intraretinal
migration of retinal pigment epithelium in agerelated macular degeneration by polarization
sensitive SLO and OCT. Masahiro Miura1, 2, S.
Sugiyama3, 5, A. E. Elsner4, S. Makita5, Y. Hong5, Y.
Yasuno5, T. Iwasaki1, 2, H. Goto2. 1Tokyo Medical
University, Ibaraki Medical Center, Ophthalmology,
Ami, Japan; 2Tokyo Medical University,
Ophthalmology, Tokyo, Japan; 3Tomey Corp,
Nagoya, Japan; 4School of Optometry, Indiana
University, Bloomingtom, IN; 5Computational
Optics Group, Univ of Tsukuba, Tsukuba, Japan
*CR
3773 — 4:15 Evaluating choroidal
pigmentation in the setting of polypoidal
choroidal vasculopathy in a Caucasian
population. Talia R. Kaden1, A. C. Tan2, F. Gilani2,
S. Zahid1, L. Yannuzzi2. 1Ophthalmology, New York
University, New York, NY; 2Vitreous Retina Macula
(VRM) Consultants, New York, NY
3774 — 4:30 Autofluorescent (AF) sub-retinal
pigment epithelium (sub-RPE) deposits in agerelated macular degeneration (AMD) accumulate
preferentially at the fovea. Thomas Ach1, 3, J. S.
Koplon3, C. E. Huisingh3, J. D. Messinger3, A. V.
Zarubina3, K. R. Sloan2, C. A. Curcio3. 1Department
of Ophthalmology, University Hospital Wuerzburg,
Wuerzburg, Germany; 2Computer and Information
Sciences, University of Alabama at Birmingham,
Birmingham, AL; 3Department of Ophthalmology,
University of Alabama at Birmingham,
Birmingham, AL *CR
3775 — 4:45 Histological stages of subretinal
drusenoid deposits (SDD) in eyes with agerelated macular degeneration (AMD). Christine
A. Curcio1, J. D. Messinger1, Y. Zhang1, D. Neely1,
K. Freund2, 3, R. F. Spaide2, 3. 1Ophthalmology, Univ
of Alabama at Birmingham, Birmingham, AL;
2
Vitreous Retina Macula Consultants of New York,
New York, NY; 3LuEsther T. Mertz Retinal
Research Center, Manhattan Eye, Ear, and Throat
Hospital Manhattan Eye, Ear, and Throat Hospital,
New York, NY *CR
3781 — 4:30 Loss of human corneal epithelial
cell identity exhibited by deletion of PAX6 using
the CRISPR/Cas9 system. Koji Kitazawa1, 2, T.
Hikichi2, T. Nakamura3, C. Sotozono1, S. Kinoshita3,
S. Masui2, 4. 1Ophthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan; 2Center for
iPS Cell Research & Application, Kyoto, Japan;
3
Frontier Medical Science and Technology for
Ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan; 4CREST, Tokyo, Japan
*CR
3776 — 5:00 Fully Automated Identification
of Lesion Activity in Neovascular AMD. Anat
Loewenstein1, D. Goldenberg1, U. Chakravarthy2,
G. Young3, M. Havilio3, O. Rafaeli3, G.
Benyamini3.1Ophthalmology, Tel Aviv Medical
Center, Tel Aviv, Israel; 2Queen’s University, Center
for Experimental Medicine, Belfast, Ireland; 3Notal
Vision, Tel Aviv, Israel *CR
3782 — 4:45 Small Wnt Inhibitors Modulate
the Expansion of Limbal Stem/Progenitor Cells
in vitro. Hua Mei, C. Zhang, E. R. Baclagon, J. J.
Zheng, S. X. Deng. Department of Ophthalmology,
Jules Stein Eye Institute, UCLA, Los Angeles, CA
3777 — 5:15 Automated identification
and quantification of subretinal fibrosis in
neovascular age-related macular degeneration
using polarization-sensitive optical coherence
tomography. Philipp K. Roberts2, M. Sugita1, G.
Dèak2, B. Baumann1, S. Zotter1, M. Pircher1, S.
Sacu2, C. K. Hitzenberger1, U. Schmidt-Erfurth2.
1
Center for Medical Physics and Biomedical
Engineering, Medical University of Vienna, Vienna,
Austria; 2Department of Ophthalmology, Medical
University of Vienna, Vienna, Austria *CR
Room 606/607
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Cornea
363 Corneal cell and molecular biology
and imaging
Moderators: Sophie X. Deng, Che J. Connon and
Friedrich E. Kruse
3778 — 3:45 Limbal Stem Cells Activate
Autophagy to Recruit Ocular Master Regulator
PAX6 in Cellular Stress Response to Ultraviolet
A Radiation. Maria Laggner, A. Pollreisz,
G. Schmidinger, U. Schmidt-Erfurth, Y. Chen.
Ophthalmology, Medical University of Vienna,
General Hospital of Vienna, Vienna, Austria
3779 — 4:00 Autophagy, a protective factor
in limbal epithelium, is positively regulated
by a microRNA family. Han Peng1, J. Kook1,
J. Katsnelson2, W. Yang1, C. He1, R. M. Lavker1.
1
Northwestern University, Chicago, IL; 2Rush
Medical College, Chicago, IL
3780 — 4:15 Screening apoptosis markers in
human corneal endothelium and epithelium.
Siddharth Mahajan, D. Thieme, F. E. Kruse, T.
A. Fuchsluger. Department of Ophthalmology,
University of Erlangen-Nurnberg, Erlangen,
Germany
3783 — 5:00 Bowman’s Layer Acoustic
Impedance in Normal and Keratoconus
Corneas. Ronald H. Silverman1, 2, R. Urs1, H. O.
Lloyd1, T. J. Archer3, M. Gobbe3, D. Z. Reinstein3, 1.
1
Ophthalmology, Columbia University Medical
Center, New York, NY; 2F.L. Lizzi Center for
Biomedical Engineering, Riverside Research,
New York, NY; 3London Vision Clinic, London,
United Kingdom *CR
3784 — 5:15 Potential Of High Resolution
Gabor-Domain Optical Coherence Microscopy
For Early Diagnosis Of Corneal Disease. Patrice
Tankam1, Z. He2, G. Thuret2, H. B. Hindman1,
T. Lepine2, P. Gain2, J. P. Rolland-Thompson1.
1
Ophthalmology, University of Rochester,
Rochester, NY; 2Universite Jean Monnet,
Saint Etienne, France
Room 608
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Anatomy and Pathology/Oncology
364 Novel signaling mechanisms in
refractive development
Moderators: Thomas T. Norton and Xiaoying Zhu
3785 — 3:45 Crystalline lens thickness is
modulated by spectacle lens defocus in chicks.
Sally A. McFadden1, N. Bilton2, 1, S. Harrison1,
M. H. Howlett3, 1. 1Psychology, University of
Newcastle, Callaghan, NSW, Australia; 2School of
Biomedical Sciences, Charles Sturt University, Port
Macquarie, NSW, Australia; 3Netherlands Institute
for Neuroscience, Amsterdam, Netherlands
3786 — 4:00 Investigation of the role of
ZNF644 in emmetropization and refractive error
using zebrafish. Ross F. Collery1, T. L. Young2, B.
Link1. 1Medical College of Wisconsin, Milwaukee,
WI;2Ophthalmology and Visual Sciences,
University of Wisconsin School of Medicine and
Public Health, Madison, WI
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
260
Tuesday – Papers/Minisymposium – 3787 – 3807
3787 — 4:15 Ascorbic acid, and not L-DOPA,
protects against form-deprivation myopia
in retinal degeneration mouse models. Erica
Landis1, 2, H. Park1, R. Chakraborty1, C. Sidhu1,
P. Iuvone1, 5, M. T. Pardue3, 4. 1Ophthalmology,
Emory University, Atlanta, GA; 2Neuroscience,
Emory University, Atlanta, GA; 3Biomedical
Engineering, Georgia Institute of Technology,
Atlanta, GA; 4Center for Visual and Neurocognitive
Rehabilitation, Veterans Affairs Medical Center,
Atlanta, GA; 5Pharmacology, Emory University,
Atlanta, GA
3788 — 4:30 Intrinsic Ocular Mechanisms
Underlie Lens-Induced Astigmatism in Chicks.
William K. Stell1, V. Popa1, C. Kee2. 1Cumming
School of Medicine, University of Calgary, Calgary,
AB, Canada;2School of Optometry, The Hong Kong
Polytechnic University, Kowloon, Hong Kong
3789 — 4:45 Origin of different responses
to myopia-inducing stimuli in two guinea pig
strains. Liqin Jiang, S. Kochik, Y. Shen, C. F.
Wildsoet. Ophthalmology and Visual Sciences,
School of Optometry, UC Berkeley, Berkeley, CA
3790 — 5:00 Visually Regulated Gene
Expression of Apolipoprotein A-1 in Chick Eyes.
Jody A. Summers Rada, A. Harper, J. Moore. Cell
Biology, University of Oklahoma Health Science
Center, Oklahoma City, OK
3795 — 4:30 The molecular basis of crystallin
gene expresssion in lens: Role of FGF signaling
and c-MAF. Ales Cvekl1, Q. Xie1, R. McGreal1, R.
Harris1, S. Limi1, C. Gao4, W. Liu1, L. W. Reneker2,
L. Musil3. 1Albert Einstein Coll of Medicine, Bronx,
NY; 2University of Missouri, Columbia, MO;
3
Oregon Health Science University, Portland, OR;
4
National Eye Institute, Bethesda, MD
3796 — 4:45 Gene Expression in Single
Fiber Cells of the Ocular Lens: A window into
molecular heterogeneity in a functional tissue.
Suraj P. Bhat1, 2, R. K. Gangalum1, D. Mock1. 1Jules
Stein Eye Institute UCLA, Los Angeles, CA;
2
Molecular Biology Institute and Brain Research
Institute, UCLA, Los Angeles, CA
3797 — 5:00 Lens differentiation rides the
wave of p27Kip1 to lens fiber cell denucleation.
Allen Taylor1, S. Rowan1, M. Chang1, F. Shang1, N.
Reznikov2, L. Lyu1, 3, K. Liu1, 3. 1Tufts University,
Boston, MA;2Department of Materials, Imperial
College, London, United Kingdom; 3Key
Laboratory of Bio-Resources and Eco-Environment
of Ministry of Education, College of Life Science,
Sichuan University, Chengdu, China
3798 — 5:15 Characterization of Lens Fiber
Cell Membrane Microdomains by Proteomics
Analysis of Lipid Rafts. Vasanth Rao, R.
Pratheepa kumari, N. Skiba. Opthalmology, Duke
University, Durham, NC
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Lens
365 Lens fiber cell biology
Moderators: Velia M. Fowler and
Michael L. Robinson
3792 — 3:45 Beta1 integrin is a negative
regulator of lens epithelial to fiber cell
differentiation in the early lens. Melinda K.
Duncan, M. Pathania, Y. Wang. Biological Sciences,
University of Delaware, Newark, DE *CR
3793 — 4:00 A Critical Role for N-cadherin
in Lens Fiber Cell Migration along the EFI
for Lens Morphogenesis. Caitlin Logan1, S.
Rajakaruna1, G. Radice1, M. L. Robinson2, A.
Menko1, 3. 1Pathology Anatomy and Cell Biology,
Thomas Jefferson University, Philadelphia, PA;
2
Miami University, Oxford, OH; 3Wills Vision
Research Center at Jefferson, Philadelphia, PA
3803 — 4:45 Stereoscopic acuity as a function
of induced monocular defocus measured with an
adaptive optics simulator. Silvestre Manzanera1,
A. Alarcon2, C. Canovas2, P. Prieto1, A. Gambin1,
H. A. Weeber2, P. A. Piers2, P. Artal1. 1Laboratorio
de Optica, University of Murcia, Murcia, Spain;
2
AMO, Groningen, Netherlands *CR
3804 — 5:00 Neural Binocular Summation
Altered by Abnormal Interocular Disparities
in Normally Developed Visual Systems. Robert
Dowd1, A. Barbot1, 3, G. Yoon1, 2, K. R. Huxlin1, 3,
D. Tadin3. 1Flaum Eye Institute, University
of Rochester, Rochester, NY; 2Biomedical
Engineering, University of Rochester, Rochester,
NY; 3CVS Department, University of Rochester,
Rochester, NY
3805 — 5:15 Improving vision by pupil shape
optimization. Sergio Bonaque-González1, 2, N.
Lopez-Gil2, S. Rios1. 1Universidad de La Laguna,
Santa Cruz de Tenerife, Spain; 2Grupo de Ciencias
de la Vision, Universidad de Murcia, Murcia, Spain
*CR
Room 615/617
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Room 611/612
Room 609
3802 — 4:30 Through-focus binocular
contrast sensitivity of monofocal and multifocal
intraocular lens predicted by an adaptive optics
visual simulator. Aixa Alarcon1, C. Canovas1, S.
Manzanera2, P. Prieto2, K. Hileman3, P. A. Piers1,
P. Artal2. 1Abbott Medical Optics, Groningen,
Netherlands; 2Laboratorio de Optica, Universidad
de Murcia, Murcia, Spain; 3Abbott Medical Optics,
Santa Ana, CA *CR
Glaucoma
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Visual Psychophysics/Physiological Optics
367 Trabecular Meshwork and Aqueous
Humor Dynamics
366 Optical imaging, adaptive optics
and vision
Moderators: Haiyan Gong and Ted S. Acott
Moderators: Nancy J. Coletta and
Alberto De Castro
3799 — 3:45 Dominant role of arachidonic
acid pathways in light-activated rod-induced
neurovascular response accessed by retinal
optical imaging. Daniel Y. Tso, M. Begum.
Neurosurgery/Neuroscience/Ophthalmology, SUNY
Upstate Medical University, Syracuse, NY
3800 — 4:00 A Programmable Aperture
Adaptive Optics SLO. Stephen A. Burns, A. De
Castro, L. Sawides, T. Luo. School of Optometry,
Bloomington, IN
3801 — 4:15 Magnification Characteristics
on Optical Coherence Tomography Systems.
Dirk-Uwe G. Bartsch. Ophthalmology, Univ of
California-San Diego, La Jolla, CA *CR
3806 — 3:45 Investigation of the two types
of cellular connections of Schlemm’s canal
inner wall cells and their role in giant vacuole
and pore formation by serial block-face
scanning electron microscopy.Julia Lai1, 2, D.
Getchevski1, A. Zavras1, D. Huang1, S. Srikumar1,
H. Gong1, 2. 1Ophthalmology, Boston University
School of Medicine, Boston, MA; 2Anatomy
and Neurobiology, Boston University School of
Medicine, Boston, MA
3807 — 4:00 Crosstalk between TGFβ2 and
TLR4 in the trabecular meshwork. Colleen M.
McDowell, H. Hernandez, A. F. Clark. North Texas
Eye Research Institute, University of North Texas
Health Science Center, Fort Worth, TX *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
261
Tuesday Papers
Minisymposium
3:45 pm – 5:30 pm
3791 — 5:15 Non-visual factors influencing
emmetropization in chicks. Xiaoying Zhu2, 1,
J. Wallman3, S. A. McFadden2. 1Biology and
Vision Sciences, SUNY College of Optometry,
New York, NY; 2School of Psychology, University
of Newcastle, Callaghan, NSW, Australia; 3Biology,
City College of New York, New York, NY
3794 — 4:15 Analysis of FGFR2 Regulated
Transcripts in the Newborn Mouse Lens. Michael
L. Robinson, S. L. Padula, T. Hoang, L. Liu, C.
Liang. Biology, Miami University, Oxford, OH
3808 – 3824 – Tuesday – Papers/Minisymposium
3808 — 4:15 Schlemm Canal (SC) Response
to Elevated Intraocular Pressure (IOP) Varies
with Morphologic Phenotype. Larry Kagemann1, 2,
G. Wollstein1, H. Ishikawa1, 2, I. A. Sigal1, 2, J. S.
Schuman1, 2. 1UPMC Eye Center, Eye and Ear
Institute, Ophthalmology and Visual Science
Research Center, Department of Ophthalmology,
University of Pittsburgh School of Medicine,
University of Pittsburgh School of Medicine,
Pittsburgh, PA; 2Bioengineering, Swanson School
of Engineering, University of Pittsburgh, Pittsburgh,
PA *CR
3809 — 4:30 A role for exosomes in steroid
induced ECM accumulation in the TM. W.
Michael Dismuke, W. D. Stamer. Duke University,
Durham, NC
3810 — 4:45 The role of VEGF on outflow
facility in mice with glucocorticoid-induced
ocular hypertension. Ester Reina-Torres, J. M.
Sherwood, D. R. Overby. Bioengineering, Imperial
College London, London, United Kingdom
Tuesday Papers/
Minisymposium
3:45 pm – 5:30 pm
3811 — 5:00 The Role of Growth
Differentiation Factor-15 in Regulation of
Contractile Properties of Human Trabecular
Meshwork Cells. Arumugam Ramachandran
Muralidharan1, R. Maddala1, V. Rao1, 2.
1
Ophthalmology, Duke University Medical Center,
Durham, NC; 2Pharmacology, Duke University
School of Medicine, Durham, NC
3812 — 5:15 Human Adipose-derived Stem
Cells Integrate into Normal Mouse Trabecular
Meshwork. Yi Zhou1, 2, H. Yun1, E. Yang1, X. Xia2, J.
S. Schuman1, 3, Y. Du1, 3. 1Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 2Ophthalmology,
Xiangya Hospital, Central South University,
Changsha, China; 3Ophthalmology, McGowan
Institute for Regenerative Medicine, University of
Pittsburgh, Pittsburgh, PA
Room 618/620
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Eye Movements/Strabismus/Amblyopia/NeuroOphthalmology
368 Amblyopia
Moderators: Irene Gottlob, Huibert J. Simonsz
and Susan M. Culican
3813 — 3:45 High heterogeneity in the
receptive-field subunit maps of multiple nearby
neurons in infant V2. Bin Zhang1, 2, X. Tao2,
G. Shen2, J. M. Wensveen2, E. L. Smith2, Y. M.
Chino2. 1Optometry, Nova Southeastern University,
Plantation, FL; 2Optometry, University of Houston,
Houston, TX
3814 — 4:00 Disconnection of ipsilateral
FEF from the attention network in strabismic
amblyopia during coherent motion task. Sheila
G. Crewther1, H. Wang2, M. Liang3, T. Yu2, J. Wang3,
D. P. Crewther4, R. Laycock1, Z. Yin2. 1School of
Psychology and Public Health, La Trobe University,
Melbourne, VIC, Australia; 2Key Laboratory of
Visual Damage and Regeneration and Restoration
of Chongqing, Southwest Eye Hospital, Southwest
Hospital,Third Military Medical University,
Chongqing, China; 3Department of Radiology,
Third Military Medical University, Chongqing,
China; 4Centre for Human Psychopharmacology,
Swinburne University, Melbourne, VIC, Australia
3815 — 4:15 Binocular Interactions during
Rapid Alternating Occlusion as measured with
Visual Evoked Potentials. Hilary A. Hamer1, A.
McLeod2, A. Panorgias1. 1Vision Science, New
England College of Optometry, Malden, MA;
2
Specialty and Advanced Care, New England
College of Optometry, Boston, MA
3816 — 4:30 Home use binocular dichoptic
video content treatment for amblyopia-pilot
study. chaim Stolovitch. Ophthalmology, Tel Aviv
Medical center, Tel Aviv, Israel f
3817 — 4:45 Greater eye movement
disconjugacy with near fixation in amblyopia
during binocular viewing is associated with
increased microsaccade rate. Howard S. Ying1,
S. Rhiu3, 1, C. Yang1, V. Xu2, R. Geary2, B. I.
Gramatikov2, D. L. Guyton2, K. Irsch2. 1Ophthal
& Visual Sciences, Boston University School
of Medicine, Boston, MA; 2Ophthalmology,
The Johns Hopkins University, Baltimore, MD;
3
Ophthalmology, Hallym University College of
Medicine, Hwaseong, Korea (the Republic of) *CR
3818 — 5:00 Disinvestment of populationwide eye screening at age 6-24 months in
the Netherlands. Frea Sloot1, H. Karaman1, 2,
A. Sami1, 2, S. E. Loudon1, J. Benjamins3, H. J.
Simonsz1. 1Ophthalmology, Erasmus Medical
Center, Rotterdam, Netherlands; 2Orthoptics,
University of Applied Sciences, Utrecht,
Netherlands; 3Public Health Service Icare, Meppel,
Netherlands f
3819 — 5:15 Detection of Amblyopia in Young
Children via Retinal Rivalry Using a Video
Game Styled Interface on a Tablet Device. Ryan
Gise1, S. Kane2. 1Ophthalmology, Albert Einstein
College of Medicine/ Montefiore Medical Center,
New York, NY; 2Ophthalmology, Columbia
University Medical Center, New York, NY
Room Skagit 4/5, TCC
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Immunology/Microbiology
369 Microbiology / Immunology /
Translational / Innate immunity
Moderator: Lucy H. Young
3820 — 3:45 Phenotypic and functional
characterization of intraocular T cell response
in intraocular tuberculosis. Soumyava Basu1, 2,
R. Tagirasa3, M. Barik1, 2, S. Devadas3. 1Retina and
Uveitis, LV Prasad Eye Institute, Bhubaneswar,
India; 2Prof Brien Holden Eye Research Institute,
Bhubaneswar, India; 3Institute of Life Sciences,
Bhubaneswar, India f
3821 — 4:00 Thrombospondin-derived peptide
attenuates Sjögren’s syndrome-associated ocular
surface inflammation. Laura Contreras-Ruiz1,
F. A. Mir2, B. Turpie1, S. Masli1. 1Department
of Ophthalmology, Boston University School
of Medicine, Boston, MA; 2Hamad Medical
Corporation, iTRI, Doha, Qatar *CR
3822 — 4:15 Identifying the mechanism
of NF-kB activation by Toxoplasma gondii’s
strain II dense granule GRA15 (GRA15 (II)).
Eleni Konstantinou1, N. Yang3, J. P. Saeij2, L. H.
Young1. 1Ophthalmology, Massachusetts Eye and
Ear Infirmary, Harvard Medical School, Boston,
MA; 2The department of Pathology, Microbiology
& Immunology at, The University of California,
Davis, CA; 3Singapore Institute for Clinical
Sciences, Singapore, Singapore
3823 — 4:30 Rose bengal-mediated
photodynamic antimicrobial therapy to inhibit
Pseudomonas aeruginosa isolates in agar plates
and contaminated contact lens cases. Heather A.
Durkee1, N. Relhan1, A. Arboleda1, M. C. Aguilar1,
K. A. Alawa1, F. Halili1, C. Rowaan1, G. Amescua2,
H. W. Flynn2, D. Miller3, J. A. Parel1, 4. 1Ophthalmic
Biophysics Center, Department of Ophthalmology,
Bascom Palmer Eye Institute, University of Miami
Miller School of Medicine, Miami, FL; 2Anne Bates
Leach Eye Hospital, Department of Ophthalmology,
Bascom Palmer Eye Institute, University of
Miami Miller School of Medicine, Miami, FL;
3
Ocular Microbiology Laboratory, Department
of Ophthalmology, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 4CHU Sart-Tillman, Department of
Ophthalmology, University of Liege, Liege, Belgium
3824 — 4:45 Contrary effects of Interleukin-1
receptor antagonist (Ra) and IL-36Ra on corneal
innate immune defense against Pseudomonas
aeruginosa keratitis. Nan Gao1, F. X. Yu1, T.
Standiford2.1Wayne State Univ/Kresge Eye
Inst, Detroit, MI; 2Pulmonary and Critical Care
Medicine, Ann Arbor, MI
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
262
Tuesday – Papers/Minisymposium – 3825 – 3841
3825 — 5:00 TLR2 and ALX/FPR2 receptor
“cross talk” is essential for Resolvin D1 (RvD1)mediated inflammation resolution and protection
in Staphylococcus aureus endophthalmitis. Pawan
Kumar Singh1, 2, A. Kumar1, A. Kumar1, 2. 1Kresge
Eye Institute, Wayne State University School of
Medicine, Detroit, MI; 2Department of Anatomy
and Cell Biology, Wayne State University School of
Medicine, Detroit, MI
3826 — 5:15 A Novel Pollen/TLR4 Concept,
an Innate Immunity Signaling Initiating IL33/ST2 Pathways in Th2-dominant Allergic
Inflammation. De-Quan Li1, J. LI1, 2, L. Zhang1,
X. Chen1, 2, S. C. Pflugfelder1, X. Hua1, F. Bian1.
1
Ophthalmology, Baylor College of Medicine,
Houston, TX; 2School of Optometry and
Ophthalmology, Wenzhou Medical University,
Wenzhou, China
Room Tahoma 1/2, TCC
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Retinal Cell Biology
370 Retinal Development II: Cell
differentiation and determination
Moderators: Luca Della Santina and
Andrew J. Fischer
3828 — 4:00 Tet2 and Tet3 methylcytosine
dioxygenases are required for retinal
neurogenesis during zebrafish eye development.
Jeffrey M. Gross, P. Seritrakul. Ophthalmology,
University of Pittsburgh School of Medicine,
Pittsburgh, PA
3829 — 4:15 The microRNA miR-18a regulates
NeuroD and photoreceptor differentiation. Scott
M. Taylor, P. F. Hitchcock. Ophthalmology and
Visual Sciences, University of Michigan,
Ann Arbor, MI
3830 — 4:30 Type 4 cone bipolar cell dendrite
morphology is maintained by DSCAM and BAX
in the adult mouse retina. Aaron B. Simmons1,
S. Bloomsburg1, D. Briggs1, J. Hix3, E. Pecor3, S.
Billingslea1, J. Young1, P. G. Fuerst1, 2. 1Biological
Sciences, University of Idaho, Moscow, ID;
2
WWAMI Medical Education Program, University
of Idaho, Moscow, ID; 3North Idaho College, Coeur
d’Alene, ID
3832 — 5:00 Reelin and Synaptic Genes are
Enriched in GCL Transcriptome during Early
Inner Plexiform Layer Development. Steve T.
Huynh1, D. M. Sherry4, P. Gunaratne2, 3, D. C.
Otteson1, 3. 1College of Optometry, University
of Houston, Houston, TX; 2Baylor College of
Medicine, Houston, TX; 3Department of Biology,
University of Houston, Houston, TX; 4Health
Sciences Center, University of Oklahoma,
Oklahoma CIty, OK
3833 — 5:15 The role of Satb2 in establishing
Direction-Selective Retinal Ganglion Cell
identity in the mouse retina. Andreea Nistorica,
N. Sweeney, D. Feldheim. MCDB, University of
California Santa Cruz, Santa Cruz, CA
Room Tahoma 3, TCC
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Clinical/Epidemiologic Research
371 A wide view on Glaucoma
epidemiology
Moderators: Paul R. Healey and
Andrew J. Tatham
3834 — 3:45 Twelve years incidence of
open-angle glaucoma in the Thessaloniki
Eye Study. Fotis Topouzis1, M. Wilson2, A.
Harris3, P. Founti1, 4, F. Yu5, 6, T. Pappas1, E.
Anastasopoulos1, A. Salonikiou1, V. Kilintzis1, A.
L. Coleman5, 7. 1Department of Ophthalmology,
School of Medicine, Aristotle University of
Thessaloniki, Thessaloniki, Greece; 2Wayne State
University, Detroit, MI; 3Indiana University School
of Medicine, Indianapolis, IN; 4Moorfields Eye
Hospital, London, United Kingdom; 5Stein Eye
Institute, University of California Los Angeles
(UCLA), Los Angeles, CA; 6Department of
Biostatistics, Fielding School of Public Health,
University of California Los Angeles (UCLA),
Los Angeles, CA; 7Department of Epidemiology,
Fielding School of Public Health, University of
California Los Angeles (UCLA), Los Angeles, CA
*CR
3835 — 4:00 Sex hormone levels and
risk of primary open-angle glaucoma in
postmenopausal women. Jae H. Kang2, J.
L. Wiggs1, L. R. Pasquale1, 2. 1Department of
Ophthalmology, Brigham and Women’s Hospital,
Boston, MA; 2Medicine, Brigham and Women’s
Hospital / Harvard Medical School, Boston, MA
3836 — 4:15 Evaluation of activity-normalized
fall rates in glaucoma. Pradeep Y. Ramulu, A.
Mihailovic, S. K. West, D. S. Friedman. Wilmer Eye
Inst/Johns Hopkins, Baltimore, MD *CR
3837 — 4:30 Association between Glaucoma
Progression and Medication Adherence: 7-Year
Study of Veterans Affairs Maryland Health Care
System Database. Eva DeVience1, S. DeVience2,
K. Williams1, M. V. Boland3, L. Im1, R. Ballinger4,
D. S. Friedman5, O. Saeedi1. 1Department of
Ophthalmology, University of Maryland, Baltimore,
MD; 2University of Maryland, Baltimore, MD;
3
Wilmer Eye Institute and Health Sciences
Informatics, Baltimore, MD; 4VA Maryland
Health Care System, Baltimore, MD; 5Wilmer Eye
Institute, Baltimore, MD
3838 — 4:45 Cost-effectiveness analysis of
following patients with glaucoma. Vishva M.
Danthurebandara, J. R. Vianna, G. P. Sharpe, D.
Hutchison, A. Belliveau, L. Shuba, M. T. Nicolela,
B. C. Chauhan. Ophthalmology and Visual
Sciences, Dalhousie University, Halfax, NS, Canada
*CR
3839 — 5:00 Cost-utility analysis of cataract
extraction by phacoemulsification versus
combined phacotrabeculectomy in treating
chronic angle closure glaucoma (CACG) with
coexisting cataract. Xiaofei MAN. Ophthalmology,
Xin Hua Hospital Affiliated to Shanghai Jiao Tong
University School of Medicine, Shanghai, China
3840 — 5:15 Driving Performance in
Subjects with Glaucomatous Visual Field Loss
as Investigated in a Driving Simulator. Amir
Marvasti, A. Diniz-Filho, E. R. Boer, P. Rosen, F.
A. Medeiros. Shiley Eye Institute, University of
California, San Diego, San Diego, CA *CR
Room Tahoma 4, TCC
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Biochemistry/Molecular Biology
372 Photoreceptor degeneration and
phototransduction
Moderators: Michael Redmond, Radha Ayyagari
and Christian Grimm
3841 — 3:45 ARL2BP is essential for the
function of rod and cone photoreceptor cells.
Abigail R. Hayes1, 2, R. Singh2, V. Ramamurthy1, 2.
1
Biochemistry, West Virginia University,
Morgantown, WV;2Ophthalmology, West Virginia
University, Morgantown, WV
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
263
Tuesday Papers
Minisymposium
3:45 pm – 5:30 pm
3827 — 3:45 Laminin β2 Chain Regulates
Retinal Progenitor Cell Mitotic Spindle
Orientation. Dmitri Serjanov, G. bachay, D. D.
Hunter, W. J. Brunken. Ophthalmology, Upstate
Medical University, Syracuse, NY
3831 — 4:45 Ccnd1-Cdk4 stimulates Müller
glia cell cycle re-entry in the mouse retina.
Sheik Pran Babu Sardar Pasha1, 2, F. Calegari3, M.
Karl1, 2. 1Retinal Regeneration and Degeneration,
Deutsches Zentrum für Neurodegenerative
Erkrankungen e. V. (DZNE) in der HelmholtzGemeinschaft, Dresden, Germany; 2Retinal
Development & Regeneration, Technische
Universität Dresden,DFG-Center for Regenerative
Therapies Dresden & Cluster of Excellence,
Dresden, Germany; 3Neural Stem Cells in the
Mammalian Brain, Technische Universität Dresden,
DFG-Center for Regenerative Therapies Dresden
(CRTD)& Cluster of Excellence, Dresden, Germany
3842 – 3852 – Tuesday – Papers/Minisymposium
3842 — 4:00 Trafficking of transducin-α by
UNC119A/B and ARL3GTP dependent diffusion.
Wolfgang Baehr, C. D. gerstner, C. HankeGogokhia, G. ying, J. M. Frederick. Ophthalmology,
Univ of Utah Sch of Med, Salt Lake City, UT
3843 — 4:15 The Role of Circadian Rhythms in
Regulating the Cone Phototransduction Cascade
Shutoff in Zebrafish Retina. Stephan C. Neuhauss,
J. Keim, J. Zang. Institute of Molecular Life
Sciences, University of Zurich, Zurich, Switzerland
3844 — 4:30 Posttranslational Lipid
Modification Controls the Trafficking of
Transducin to the Photoreceptor Cilium. Maxim
Sokolov, M. Belcastro, J. Murphy, S. Kolandaivelu.
Ophthalmology, West Virginia Univ Eye Institute,
Morgantown, WV
Tuesday Papers/
Minisymposium
3:45 pm – 5:30 pm
3845 — 4:45 Ablation of Retbindin Alters
Flavin Levels and Leads to Rod and Cone
Photoreceptor Degeneration. Muayyad R.
Al-Ubaidi1, R. Kelley2, J. Du3, J. Hurley4, M. I.
Naash1. 1Biomedical Engineering, University of
Houston, Houston, TX; 2Cell Biology, University of
Oklahoma, Oklahoma city, OK; 3Ophthalmology,
University of Washington, Seattle, WA;
4
Biochemistry, University of Washington, Seattle, WA
3846 — 5:00 Design, generation, and initial
characterization of gene-edited mice for
the analysis of the peripherin-2/rds (P/rds)
cytoplasmic C-terminal domain. Andrew F.
Goldberg1, B. Cavanaugh1, M. L. Milstein1, V. A.
Kimler1, K. P. Mitton1, T. Saunders2. 1Eye Research
Institute, Oakland University, Rochester, MI;
2
Transgenic Animal Model Core, University of
Michigan, Ann Arbor, MI
3847 — 5:15 Long-term treatment with 9-cisβ-carotene rich alga Dunaliella Bardawil inhibits
photoreceptor degeneration in a mouse model of
retinoid cycle defect. Ifat Sher1, 2, V. Edelshtain1, 2,
A. Tzameret1, 2, D. Harats3, A. Shaish3, Y.
Rotenstreich1, 2. 1Goldschleger Eye Institute, Sheba
Medical Center, Tel-Hashomer, Israel; 2Sackler
Medical School, Tel Aviv University, Tel Aviv,
Israel; 3The Bert W. Strassburger Lipid Center,
Sheba Medical Center, Tel Hashomer, Israel
Room Tahoma 5, TCC
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Visual Neuroscience
373 Connecting the retina to the brain:
The mouse - Minisymposium
The advent of powerful molecular tools available
in the mouse has seen many investigators shift their
focus to this animal model. This minisymposium
highlights recent studies in the mouse that advance
understanding of the function and diversity of
retinal ganglion cells, the connections from the
retinal ganglion cells to high visual areas, and
the organization of the central visual targets. The
speakers will be asked to compare the mouse model
with other larger animal models where similar
earlier studies have been performed.
Moderators: William R. Taylor and Scott A. Nawy
3848 — 3:45 What the mouse eye tells the
mouse’s brain: a functional classification of
retinal ganglion cells. Tom Baden. Bernstein
Centre for Computational Neuroscience, University
of Tuebingen, Tuebingen, Germany; Centre for
Integrative Neuroscience, University of Tuebingen,
Tuebingen, Germany
3849 — 4:05 Multiple synaptic mechanisms
underlying direction selectivity in the mouse
retina. Wei Wei. University of Chicago, Chicago, IL
3850 — 4:25 New roles for intrinsically
photosensitive retinal ganglion cells. Tiffany
Schmidt. Neurobiology, Northwestern University,
Evanston, IL
3851 — 4:45 Direction Selectivity in the Mouse
Superior Colliculus. Jianhua Cang. Northwestern
University, Evanston, IL
3852 — 5:05 Visual processing in the mouse
thalamocortical pathway. Cristopher Niell.
Biology Dept / Institute of Neuroscience, University
of Oregon, Eugene, OR
— 5:25 Discussion
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
264
Tuesday – Posters – 3853 – 3874
Exhibit/Poster Hall A0001-A0044
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Cornea
374 Ocular Surface Health and Disease
Moderator: Noriko Koizumi
3853 — A0001 APR-246/PRIMA-1Met inhibits
and reverses squamous metaplasia in human
conjunctival epithelium. Cheng Li, W. Li, Z. LIU,
J. Li. Ophthalmology and Visual Sciences, Eye Inst
& Affiliated Xiamen Eye Ctr, Xiamen, China
3854 — A0002 The Effect of Betadine on
Vision. Caren Oquindo1, W. H. Ridder1, K.
Dhamdhere2, J. A. Burke2. 1Southern California
College of Optometry, Marshall B. Ketchum
University, Fullerton, CA; 2Allergan, Inc.,
Irvine, CA *CR
3855 — A0003 The Effect of Betadine on Vision
and on Cornea in Rabbits. Kavita Dhamdhere, A.
S. Almazan, M. Engles, J. A. Burke. Allergan Inc,
Irvine, CA
3856 — A0004 Hoxc8 misexpression prevents
embryonic eyelid fusion and transforms cornea
and conjunctiva into keratinized skin. Lara S.
Carroll. Moran Eye Center, University of Utah, Salt
Lake City, UT
3858 — A0006 IKZF1 Expression and
Upregulation by polyI:C in Human Ocular
Surface Epithelial Cells. Mayumi Ueta1, H.
Nishigaki1, K. Shinomiya2, N. Yokoi2, C. Sotozono2,
S. Kinoshita1. 1Department of Frontier Medical
Science and Technology for Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan;
2
Department of Opthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan
3859 — A0007 Ocular Surface Adverse
Events of Systemic Inhibitors of the Epidermal
Growth Factor Receptor (EGFRi): a Prospective
Trial. Alejandro Saint-Jean1, 2, A. Eixarch2, N.
Reguart4, N. Pardo4, C. Castella2, 3, M. Sainz De La
Maza2, A. Adan Civera2, B. Sanchez Dalmau2, M.
Aldea5, R. Torres2. 1Ophthalmology, CHU Nantes,
Nantes, France; 2Ophthalmology, Hospital Clinic
Barcelona, Barcelona, Spain; 3Clinique Sourdille,
Nantes, France; 4Oncology Department, Hospital
Clinic, Barcelona, Spain; 5Unit of Infections and
Cancer (UNIC), Cancer Epidemiology Research
Programme, Institute of Oncology, IDIBELL,
Barcelona, Spain f
3861 — A0009 PROSE lens use for exposure
keratopathy in trigeminal and facial nerve
palsies. Elizabeth Marlow, J. Ciralsky, M. Lee,
G. Lelli. Ophthalmology, Weill Cornell Medical
College, New York, NY
3862 — A0010 Impact of conjunctival
autograft on pterygium treatment: evaluation
of related symptoms and patients satisfaction
after surgery. Bruna Duarte Moron de Andrade,
G. Capecci Siqueira, P. Dechichi Neto, A. Terra
Baccega, M. Gonçalves Monteiro Viturino, A. Mylla
Boso, D. de Paiva Almeida, M. Alves. Department
of Ophthalmology, UNICAMP, Campinas, Brazil
3863 — A0011 Correlation between Meibomian
Gland Dysfunction and Keratitis in Patients with
Demodex Brevis Infestation. Lingyi Liang1, H.
Ke1, S. C. Tseng2. 1Cornea, Zhongshan Ophthalmic
Center, Guangzhou, China; 2Ocular Surface
Research and Education Center, Miami, FL *CR
3864 — A0012 The Evaluation of Worldwide
Distribution of Adenoviral Genotypes in Acute/
Epidemic Keratoconjunctivitis and Adenoviralnegative Keratoconjunctivitis with Next
Generation Sequencing.Cecilia S. Lee1, A. Y.
Lee1, L. Akileswaran1, D. W. Stroman2, K. NajafiTagol2, S. Kleiboeker4, A. Wald3, R. N. Van Gelder1.
1
Ophthalmology, University of Washington, Seattle,
WA; 2NovaBay Pharmaceuticals, Inc., Emeryville,
CA; 3Infectious Diseases, University of Washington,
Seattle, WA; 4ViraCor-IBT Laboratories, Inc, Lee’s
Summit, MO *CR, f
3865 — A0013 Safety and efficacy study
to evaluate wiping the lid margins with tap
water alone or in combination with lid hygiene
shampoo in subjects with normal meibomian
glands. Hirotaka Tanabe, M. Kaido, M.
Kawashima, R. Ishida, K. Tsubota. Ophthalmology,
Keio Univ School of Medicine, Tokyo, Japan *CR, f
3866 — A0014 Histatin-1 as a peptide based
therapy for human corneal epithelial wound
healing. Dhara Shah, Z. Pasha, M. Ali, V. K.
Aakalu. Department of Ophthalmology, University
of Illinois at Chicago, Chicago, IL
3867 — A0015 Non-invasive technique for
dynamic measurement of tear film surface
quality based on interferometry. Dorota H.
Szczesna-Iskander, S. Drobczynski. Dept. of Optics
and Photonics, Wroclaw University of Technology,
Wroclaw, Poland
3868 — A0016 Stimulation of Corneal
Nociceptors Results in Pro-inflammatory
Molecular and Cellular Responses. Yashar SeyedRazavi1, 2, P. Hamrah3, 4. 1Ophthalmology, Tufts
Medical Center, Boston, MA;2Ophthalmology,
Schepens Eye Research Institute/Massachusetts Eye
and Ear, Harvard Medical School, Boston, MA;
3
Ophthalmology, Schepens Eye Research Institute/
Massachusetts Eye and Ear, Cornea & Refractive
Surgery Service, Harvard Medical School, Boston,
MA; 4Ophthalmology, Cornea Service, New
England Eye Center, Tufts Medical Center,
Boston, MA
3869 — A0017 Crosstalk Between Selective
Autophagy and Nrf2-ARE Pathway Through
p62/SQSTM1 Confers Limbal Stem Cell
Resistance to Ultraviolet-A Irradiation. Ying-Ting
Chen1, M. Laggner1, F. Gruber2, E. Tschachler2,
U. Schmidt-Erfurth1, A. Pollreisz1. 1Department
of Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Department of Dermatology,
Medical University of Vienna, Vienna, Austria
3870 — A0018 Ocular surface stories after
cataract surgery. Rodrigo M. Torres1, 2, P. G.
Lódolo1, 2. 1Ophthalmology, Centro de Ojos Dr
Lodolo, Colonia Avellaneda, Argentina; 2Asociación
Entrerriana de Oftalmología, Paraná, Argentina
3871 — A0019 A Structural Equation Model
(SEM) Relating Eye Pain (EP) and Ocular
Surface Measurements (OSMs). Richard A.
Bilonick1, 2, A. Galor3. 1UPMC Eye Center, Eye and
Ear Institute, Ophthalmology and Visual Science
Research Center, Department of Ophthalmology,
University of Pittsburgh School of Medicine,
Pittsburgh, PA; 2Biostatistics, University of
Pittsburgh Graduate School of Public Health,
Pittsburgh, PA; 3Bascom Palmer Eye Institute,
University of Miami, Miami, FL
3872 — A0020 Human blinking ‘eye-on-achip’. Jeongyun Seo1, W. Y. Byun1, A. Frank1, M.
Massaro-Giordano2, V. Lee2, V. Y. Bunya2, D. Huh1.
1
Bioengineering, University of Pennsylvania,
Phildelphia, PA;2Scheie Eye Institute, Department
of Ophthalmology, Perelman School of Medicine
at the University of Pennsylvania, Philadelphia, PA
*CR
3873 — A0021 A disease model of aqueous
deficient dry eye in a microengineered ocular
surface tear film platform. Nicole Qiaozhi Lu, M.
P. Grant, J. Elisseeff. Wilmer Eye Institute, Johns
Hopkins University, Baltimroe, MD
3874 — A0022 Contralateral investigation of
postoperative refractive surgery inflammation:
Small-incision Lenticule Extraction vs LASIK.
Marianthi Stergiou1, A. J. Kanellopoulos1, 2, G.
Asimellis1, 3.1LaserVision.gr Eye Institute, Athens,
Greece; 2Ophthalmology, NYU Medical School,
NY, NY; 3Kentucky College of Optometry,
Pikeville, KY *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
265
Tuesday Posters
3:45 pm – 5:30 pm
3857 — A0005 Identification and
Characterization of Long Noncoding RNA
Contributions to Mouse Corneal Development.
Weiwei Chen1, 2, S. Yang1, 2, Z. Zhou1, 2, X. Zhao1, 2,
D. Yan1, 2. 1State Key Laboratory of Ophthalmology,
Wenzhou Medical University, Wenzhou, China;
2
School of Ophthalmology and Optometry,
Wenzhou Medical University, Wenzhou, China
3860 — A0008 A role of primary cilia in
Anterior Segment Dysgenesis disorders. Carlo
Iomini, G. Laura, E. Revenkova. Ophthalmology,
Icahn School of Medicine at Mount Sinai,
New York, NY
3875 – 3896 – Tuesday – Posters
3875 — A0023 First Report of Simultaneous
Double-Headed Pterygiectomy with Conjunctival
Autograft, Amniotic Membrane and Fibrin
Glue. Jenny Ha1, J. A. Martinez1, 2, Y. Hosseini1,
M. Korchak2, J. Koppinger3, 2, S. L. Cremers1.
1
Visionary Ophthalmology, Rockville, MD;
2
Ophthalmology, Medstar Georgetown University
Hospital / Washington Hospital Center, Washington,
DC; 3Georgetown University School of Medicine,
Washington, MD
3876 — A0024 The impact of meibomian gland
dysfunction on the ocular surface parameters
of glaucoma patients on long-term topical
hypotensive medications. Mehmet C. Mocan,
E. Uzunosmanoglu, S. Kocabeyoglu, M. T. Irkec.
Department of Ophthalmology, Hacettepe Univ
School of Medicine, Ankara, Turkey
Tuesday Posters
3:45 pm – 5:30 pm
3877 — A0025 Microfluidic system based
high throughput toxicity and efficacy screening
system for eyedrops in ocular surface
experiments. Kyong Jin Cho2, J. Ju3, R. Lee1, D.
Kim5, 4, J. Kim1.1Biomedical Science, Dankook
University Graduate School, Cheonan, Korea
(the Republic of); 2Ophthalmology, College of
Medicine, Dankook University, Cheonan, Korea
(the Republic of); 3Biomedical Engineering, College
of Health Science, Korea University, Seoul, Korea
(the Republic of); 4Biomedical Engineering, College
of Medicine, Dankook University, Cheonan, Korea
(the Republic of); 5Beckman Laser Institute Korea,
Cheonan, Korea (the Republic of)
3878 — A0026 Signal detection theory
examination of ocular surface sensory processing
of corneal pneumatic stimuli. Varadharajan
Jayakumar, T. L. Simpson. University of Waterloo,
Waterloo, ON, Canada
3879 — A0027 Ocular Involvement In
Sjogren’s syndrome - The Singapore Sjogren’s
Syndrome Study. Rachel Lim, D. Gunasekeran,
J. Kam, B. Thong, R. V. Agrawal. Tan Tock Seng
Hospital, Singapore, Singapore
3880 — A0028 HLA class I genes associated
with Cold Medicine related Stevens-Johnson
Syndrome with Severe Ocular Complications in
the Brazilian population. Tais H. Wakamatsu1, M.
Ueta2, K. Tokunaga3, Y. Okada4, R. R. Loureiro1,
K. A. Costa1, J. M. Sallum1, J. Milhomens1, C.
Sotozono5, J. P. Gomes1, S. Kinoshita5. 1Federal
University of Sao Paulo, Sao Paulo, Brazil;
2
Department of Frontier Medical Science and
Technology for Ophthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan; 3Department
of Human Genetics, University of Tokyo, Tokyo,
Japan; 4Human Genetics and Disease Diversity,
Tokyo Medical and Dental University, Tokyo,
Japan; 5Department of Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan
3881 — A0029 Evaluation Of Changes In
Ocular Surface After Vitrectomy Surgery. Chiara
Del Noce, F. Bruzzone, S. Lai, M. ROLANDO, C.
E. Traverso. DINOGMI, University of Genoa Eye
Clinic, Genoa, Italy
3882 — A0030 Deletion of the Vitamin D
Receptor Affects Meibomian Gland of Mice. Kai
Jin1, M. Kawashima1, M. Ito2, K. Sano1, K. Tsubota1.
1
Ophthalmology, Keio University, school of
medicine, Tokyo, Japan; 2National Defense Medical
College, Saitama, Japan
3883 — A0031 Calculating the health
economic burden of microbial keratitis (MK)
admission in a tertiary referral centre in the
UK. Jasvir Virdee1, G. Moussa1, N. Gooch2, J.
Kigozi2, C. Penaloza2, S. Rauz1. 1Academic Unit of
Ophthalmology, The University of Birmingham,
Birmingham, United Kingdom; 2Health Economics
Unit, The University of Birmingham, Birmingham,
United Kingdom
3884 — A0032 Using corneal chemical
detection thresholds to select subjects for ocular
surface discrimination sensory panels. Trefford
L. Simpson4, 1, N. J. Keir2, W. Ngo3, 1, Y. Feng4, 1.
1
University of Waterloo, Waterloo, ON, Canada;
2
Cooper Vision, Pleasanton, CA; 3School of
Optometry & Vision Science, Centre for Contact
Lens Research, Waterloo, ON, Canada; 4School
of Optometry & Vision Science, Waterloo, ON,
Canada *CR
3885 — A0033 Ocular Surface Homeostatic
Surveillance by Th17 Cells in the Closed Eye.
Cameron K. Postnikoff, K. K. Nichols. Vision
Sciences, University of Alabama at Birmingham,
Birmingham, AL
3886 — A0034 Grading Bulbar Redness Using
The Keratograph 5M. Correlations With Efron
And Mcmonnies Scales. Néstor Ventura Abreu1,
F. Pérez Bartolomé1, C. Sanz Pozo1, J. Martínez de
la Casa1, J. Moreno-Montanes2. 1Ophthalmology,
Hospital Clínico San Carlos, Madrid, Spain;
2
Ophthalmology, Clínica Universitaria de Navarra,
Pamplona, Spain
3887 — A0035 Novel pterygium animal
model using White New Zealand rabbit and
murine fibroblasts (NIH 3T3 cell line). Julio C.
Hernandez2, J. E. Valdez2, J. Zavala2, J. Valenzuela1.
1
Tecnologico de Monterrey, School of Medicine,
Monterrey, Mexico; 2Ophthalmology and Visual
Sciences Research Chair, Tecnologico de Monterrey
School of Medicine, Monterrey, Mexico
3888 — A0036 Lax Eyelid Syndrome,
Obstructive Sleep Apnea Syndrome (OSAS), and
Ocular Surface Inflammation. Mackenzie Becker1,
C. Kirk1, R. Narala2, S. Kumar1, W. Adams1, C. S.
Bouchard1.1Ophthalmology, Loyola University
Medical Center, Maywood, IL; 2Kresge, Detroit, MI
3890 — A0038 Prosthetic Replacement of
the Ocular Surface Ecosystem Therapy for
Sjogren’s Syndrome Patients. Billy X. Pan, G. B.
Chiu, M. Heur. Ophthalmology, USC Eye Institute,
Los Angeles, CA
3891 — A0039 Prevalence and risk factors of
superior limbal keratoconjunctivitis in Graves’
disease. Anfal Almazrooei1, O. Hamam1, L.
Dupasqiuer2, M. Berche1, E. Heron2, C. baudouin1,
A. Labbé1.1Service d’Ophtalmologie, CHNO des
Quinze-Vingts, Paris, France; 2Department of
Internal Medicinel, CHNO des Quinze-Vingts,
Paris, France
3892 — A0040 Modulating the toxic effects
of benzalkonium chloride on human corneal
epithelial cells in vitro. Elham Ghahari, M.
Ghahari, S. Gidfar, B. Y. Milani, S. Sanjari, M.
Eslani, T. S. Vajaranant, A. A. Aref, A. R. Djalilian.
ROI, University of Illinois at Chicago, Chicago, IL
3893 — A0041 Corneal bioimpedance
evaluation in an animal model of anterior
surface inflammation. Mario Crespo-Moral1, A.
Holgueras-López1, A. Guimerà2, 3, R. Villa2, 3, M.
Maldonado1. 1IOBA - University of Valladolid,
Valladolid, Spain; 2Institut de Microelectrònica
de Barcelona IMB-CNM (CSIC), Barcelona,
Spain; 3CIBER-BBN, Networking Center on
Bioengineering, Biomaterials and Nanomedicine,
Zaragoza, Spain*CR
3894 — A0042 Reproducibility and Outcomes
of Simple Limbal Epithelial Transplantation
(SLET) technique. Alexandra Abdala, A. J.
Ramirez-Miranda, A. Lichtinger, A. Navas, E. O.
Graue-Hernandez. Instituto de Oftalmologia Conde
de Valenciana, Mexico City, Mexico *CR
3895 — A0043 Topical Interferon Alpha-2b In
Giant Squamous Ocular Surface Neoplasia. Erick
Hernandez-Bogantes, A. Olivo-Payne, A. Abdala,
J. Serna-Ojeda, E. O. Graue-Hernandez, A. Navas,
A. J. Ramirez-Miranda. Cornea and Refractive
Surgery, Insituto de Oftalmologia Fundacion Conde
de Valenciana, Mexico D.F, Mexico
3896 — A0044 The fate of mesenchymal stem
cells after subconjunctival implantation. Juan Li,
C. Zuo, S. Ou, S. Li, L. Zhang, C. Jia, Z. Liu, W. Li.
Xiamen University Medical College, Eye Institute
of Xiamen University, Xiamen, China
3889 — A0037 A novel murine behavioral
model of ocular neuropathic pain. Romulo
Albuquerque1, J. Cho1, B. Taylor2, J. Ambati1.
1
Ophthalmology, University of Kentucky,
Lexington, KY; 2Physiology, University of
Kentucky, Lexington, KY *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
266
Tuesday – Posters – 3897 – 3918
Exhibit/Poster Hall A0183-A0237
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Glaucoma
375 Glaucoma Visual Fields and
Electrophysiology
Moderators: Mitra Sehi and Ryo Asaoka
3897 — A0183 Antigen-antibody interactions
predict the classification and progression of
glaucoma. Sarah Liebezeit, S. Beck, D. Wolters,
J. Teister, K. Lorenz, N. Pfeiffer, F. H. Grus.
Experimental Ophthalmology, Mainz, Germany
3898 — A0184 Visual Field Characteristics of
patients with Primary Angle Closure Glaucoma:
Types of defects and Hemi-field comparisons.
Eray Atalay1, M. Nongpiur1, 2, S. Perera1, 3, T. T.
Wong1, 3, T. Aung1, 3. 1Singapore Eye Research
Institute, Singapore, Singapore; 2Duke-NUS
Medical School, Singapore, Singapore; 3Singapore
National Eye Center, Singapore, Singapore
3899 — A0185 Depth of Visual Field Loss
Using Threshold Automated Perimetry Increases
with Eccentricity in Glaucoma Subjects. Robert
Wanzek1, E. Lee1, T. Eden1, A. Turpin2, L. Chong2,
M. Wall1.1University of Iowa, Iowa City, IA;
2
Computing and Information Systems, University of
Melbourne, Melbourne, VIC, Australia
3901 — A0187 Frequency of occurrence of
abnormal test points with HFA 24-2 and 10-2 in
glaucoma patients. Hiroki Nomoto, C. Matsumoto,
S. Okuyama, S. Hashimoto, T. Kayasawa, M. Eura,
T. Numata, S. Yamao, Y. Shimomura. Department
of Ophthalmology, Kinki Univ School of Medicine,
Sayama, Japan
3902 — A0188 Characteristics of glaucomatous
central visual field loss as measured with the 10-2
testing pattern. Denise Pensyl, M. Sullivan-Mee,
M. K. Tran, G. Tsan, S. Katiyar. Albuquerque VA
Medical Center, Albuquerque, NM
3903 — A0189 A modified visual field index
to measure the central visual function in eyes
with fixation involvement. Debananda Padhy, A.
Rao. Glaucoma service, L V Prasad Eye Institute,
Bhubaneswar, India
3905 — A0191 Scheie Visual Field Grading
System. Prithvi Sankar, E. G. Miller-Ellis, A.
Lehman, V. M. Addis, J. D. Henderer, D. Choi,
L. O’Keefe, M. Ramakrishnan, V. J. Natesh, G.
J. Whitehead, J. M. O’Brien. Ophthalmology,
University of Pennsylvania, Philadelphia, PA
3906 — A0192 Correlation of visual
field defects and exploratory visual search
performance in open angle glaucoma patients
using a computer digit-based task. Cassia
Senger, A. Messias, J. S. Paula. Department of
Ophthalmology, Ribeirão Preto Medical School University of São Paulo, Ribeirão Preto, Brazil
3907 — A0193 Longitudinal Changes in the
Useful Field of View and Standard Automated
Perimetry in Patients with Glaucoma. Nara
L. Lopes1, 2, C. P. Gracitelli1, 2, A. Diniz-Filho1,
A. Paranhos Jr.2, F. A. Medeiros1. 1Laboratory of
Performance and Visual Function, Department of
Ophthalmology, University of California San Diego,
La Jolla, CA; 2Department of Ophthalmology,
Federal University of Sao Paulo, São Paulo, Brazil
*CR
3908 — A0194 Is Vision-Related Quality of
Life Impaired in Patients with Preperimetric
Glaucoma? Roberta A. Nascimento1, 2, C. P.
Gracitelli1, 2, A. Diniz-Filho1, L. M. Zangwill1, R.
N. Weinreb1, A. Paranhos Jr.2, F. A. Medeiros1.
1
Laboratory of Performance and Visual Function,
Department of Ophthalmology, University of
California San Diego, La Jolla, CA; 2Department of
Ophthalmology, Federal University of São Paulo,
São Paulo, Brazil *CR
3909 — A0195 Integrated Visual Field
and Relative Risk for Quality of Life Loss.
MARCOS MUNOZ1, O. Pujol2, A. Anton-Lopez1, 2,
R. Maull2, L. Pastor2, Z. Vega2, C. Mora2, S.
Gudiña2, A. Morilla-Grasa1, V. Garcia1. 1Dept
of Ophthalmology, Institut Catala de Retina,
Barcelona, Spain; 2Parc Salut Mar, Barcelona, Spain
*CR
3910 — A0196 Minimally important
Differences in the NEI-VFQ 25: Data from the
TVT study. Aachal Kotecha1, W. J. Feuer2, K.
Barton1, S. Gedde2. 1NIHR Biomedical Research
Centre, UCL Institute of Ophthalmology &
Moorfields Eye Hospital NHS Foundation Trust,
London, United Kingdom; 2Bascom Palmer Eye
Institute, University of Miami Miller School of
Medicine, Miami, FL *CR, f
3911 — A0197 Evaluating Silent Reading
Performance with the Eye Tracking System
in Patients with Glaucoma. Noriaki Murata1, 2,
M. Daiki1, T. Togano1, T. Fukuchi1. 1Division of
Ophthalmology and Visual Science, Graduated
School of Medical and Dental Science, Niigata
University, Niigata-shi, Japan; 2Department of
Orthoptics and Visual Sciences, Faculty of Medical
Technology, Niigata University of Health and
Welfare, Niigata-shi, Japan
3912 — A0198 Predicting Driving Performance
using the Performance-Centered Portable Test
(PERCEPT) in Patients with Glaucoma. Luciana
A. Fernandez1, 2, A. Diniz-Filho1, C. P. Gracitelli1, 2,
E. R. Boer1, P. Rosen1, A. Paranhos Jr.2, F. A.
Medeiros1. 1Laboratory of Performance and
Visual Function, Department of Ophthalmology,
University of California San Diego, La Jolla, CA;
2
Department of Ophthalmology, Federal University
of São Paulo, Sao Paulo, Brazil *CR
3913 — A0199 Illness perception and beliefs
in people newly diagnosed with glaucoma and
ocular hypertension. Csilla Ajtony1, T. Boodhna2,
L. McDonald2, P. Turnbull3, R. R. Bourne3, 1,
D. Crabb2.1Glaucoma Service, Moorfields Eye
Hospital NHS Trust London, London, United
Kingdom; 2Optometry and Visual Science, School
of Health Science, City University London, London,
United Kingdom; 3Ophthalmology, Hinchingbrooke
Health Care NHS Trust, Huntingdon, United Kingdom
3914 — A0200 Preliminary Assessment of
Humphrey Visual Field Automated Perimetry
Reliability Indices as a Predictor of Mortality
Risk. Oliver L. Yeh1, R. Singh2, A. K. Junk1, 2, K.
M. Cavuoto1, T. C. Chang1, 2. 1Bascom Palmer Eye
Institute, Miami, FL; 2Ophthalmology, Miami
Veterans Affairs Healthcare System, Miami, FL
3915 — A0201 The Association between
progression of visual field loss and body mass
index in normal tension glaucoma. Kyu-Ryong
Choi, A. Kim, K. Han, R. Jun. Department of
Ophthalmology, Ewha Womans University, Seoul
3916 — A0202 Monitoring Visual Field Loss
Progression In Open Angle Glaucoma Using
Eyesuite Perimetry Software. Carmen MendezHernandez, F. Pérez Bartolomé, J. García Feijoó.
Ophthalmology, Hospital Clinico San Carlos,
Madrid, Spain
3917 — A0203 Sequence effects during visual
field assessment. Marco A. Miranda1, P. H. Artes2.
1
Visual Neuroscience, NIHR Biomedical Research
Centre, Moorfields Eye Hospital and UCL IoO,
London, United Kingdom; 2School of Health
Professions, Plymouth University, Plymouth, United
Kingdom
3918 — A0204 Visual field analysis tools for
real world clinics. Susan R. Bryan, D. Crabb.
Optometry and Visual Science, City University
London, London, United Kingdom *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
267
Tuesday Posters
3:45 pm – 5:30 pm
3900 — A0186 Preperimetric glaucoma study
1: Analysis of visual field defect in preperimetric
glaucoma. Naoko Aizawa1, Y. Shiga1, S. Tsuda1,
K. Omodaka1, Y. Yokoyama1, T. Yasui2, K. Kato3, T.
Nakazawa1. 1Ophthalmology, Tohoku University,
Sendai, Japan; 2Yasui eye clinic, Rifu, Japan; 3Kato
eye center, Taiwa, Japan *CR, f
3904 — A0190 Probable Central Nervous
System Mediated Enhancement of Perimacular
Visual Function. Shannon Leon1, W. E. Sponsel1, S.
L. Groth2, N. Satsangi5, T. Maddess4, M. A. Reilly3,
A. Schnegg1, R. Trevino1, C. Majcher1. 1Rosenberg
School of Optometry, San Antonio, TX; 2University
of North Carolina, Chapel Hill, NC; 3University of
Texas San Antonio, San Antonio, TX; 4Australian
National University, Canberra, ACT, Australia;
5
University of Texas Health Science Center,
San Antonio, TX
3919 – 3940 – Tuesday – Posters
3919 — A0205 Detecting Glaucomatous
Progression from Localized Visual Function
Changes with Corrections for Multiple
Comparison. Srinivas Rajaraman1, R. Singh1, S.
Yousefi2, C. Bowd2, L. M. Zangwill2, R. N. Weinreb2,
M. Balasubramanian1. 1Electrical and Computer
Engineering, The University of Memphis, Memphis,
TN; 2Shiley Eye Institute, University of California,
San Diego, CA *CR, f
3920 — A0206 Reducing variability of
perimetric global indices from eyes with
progressive glaucoma by censoring unreliable
sensitivity data. Manoj Pathak1, S. Demirel2, S.
K. Gardiner2. 1Mathematics and Statistics, Murray
State University, Murray, KY; 2Legacy Research
Institute, Portland, OR
3921 — A0207 Behavioural evidence that
retinal ganglion cells do not saturate with 15dB
perimetric stimuli. Andrew J. Anderson1, A. M.
McKendrick1, A. Turpin2. 1Optometry & Vision
Sciences, University of Melbourne, Parkville, VIC,
Australia; 2Computing and Information Systems,
The University of Melbourne, Parkville, VIC,
Australia
Tuesday Posters
3:45 pm – 5:30 pm
3922 — A0208 Current Perimetric Procedures
have Low Probability of Detecting Glaucomatous
Progression in Moderate to Advanced Disease.
Andrew Turpin1, A. M. McKendrick2. 1Computing
and Information Systems, University of Melbourne,
Melbourne, VIC, Australia; 2Optometry & Vision
Science, University of Melbourne, Melbourne, VIC,
Australia *CR
3923 — A0209 The detection of progression
from moderate visual field damage requires a
visual field test that assesses for spatial spread
rather than deficit depth. Allison M. McKendrick1,
W. H. Morgan2, A. Turpin3. 1Optometry & Vision
Science, University of Melbourne, Parkville,
VIC, Australia; 2Lions Eye Institute, University
of Western Australia, Nedlands, WA, Australia;
3
Computing and Information Systems, University of
Melbourne, Parkville, VIC, Australia *CR
3924 — A0210 Introducing a novel technique
to investigate performance of the GOANNA
visual field algorithm in human observers.
Luke Chong1, 2, A. Turpin3, A. M. McKendrick1.
1
Department of Optometry and Vision Sciences, The
University of Melbourne, Parkville, VIC, Australia;
2
School of Optometry, University of California
Berkeley, Berkeley, CA; 3Department of Computing
and Information Systems, The University of
Melbourne, Parkville, VIC, Australia *CR
3925 — A0211 Performance of an Accelerated
Threshold Visual Field Test Strategy. Gary
C. Lee1, A. Heijl2, P. Sha1, T. Callan1, M. K.
Durbin1, T. Severin3, S. Radhakrishnan4, 5, A. G.
Iwach4, 5, B. Bengtsson2. 1Clinical and Applications
Development, Carl Zeiss Meditec, Inc, Dublin,
CA; 2Ophthalmology, University of Lund, Malmo,
Sweden; 3East Bay Eye Center, San Ramon, CA;
4
Glaucoma Center of San Francisco, San Francisco,
CA; 5Glaucoma Research and Education Group,
San Francisco, CA *CR
3926 — A0212 Repeatability of SITA Standard
and SITA Fast Visual Fields. Sophia Yu, G. C. Lee,
M. K. Durbin, T. Callan. Clinical & Applications
Development, Carl Zeiss Meditec, Inc, Dublin, CA
*CR
3927 — A0213 Evaluating equivalence between
the new Humphrey Field Analyzer (HFA3) and
HFA II-i. Thomas Callan1, P. Sha1, J. Y. Luu1, S.
Yu1, A. Chang1, T. Severin2, Y. Duh3. 1Carl Zeiss
Meditec, Inc., Dublin, CA; 2East Bay Eye Center,
San Ramon, CA; 3ClinReg Consulting Services,
Inc., Laguna Beach, CA *CR
3928 — A0214 Reliability of the Heidelberg
Edge Perimeter (HEP) glaucoma screening
compared to conventional 24-2-visual field tests
in glaucoma patients. Matthias M. Mauschitz1, C.
K. Brinkmann2, F. G. Holz2, M. M. Breteler1, R. P.
Finger2. 1German Center for Neurodegenerative
Diseases, Bonn, Germany; 2Department for
Ophthalmology, University of Bonn, Bonn,
Germany *CR
3929 — A0215 Threshold fluctuation
comparison between Oculus Smartfield Spark
strategy and Humphrey Sita Fast. Rodrigo
Abreu1, P. Rodriguez-Esteve1, C. Pena-Betancor2,
M. Gonzalez-Hernandez2, M. Gonzalez-de la
Rosa3. 1Ophthalmology, University Hospital of
La Candelaria, El Sauzal, Spain; 2Ophthalmology,
University Hospital of the Canary Island, La
Laguna, Spain; 3University of La Laguna, La
Laguna, Spain *CR
3930 — A0216 Comparison of visual field
artifact from two visual field analyzers. Tamara
L. Berezina1, A. S. Khouri1, C. Horan2, R. D.
Fechtner1. 1Institute of Ophthalmology and Visual
Science, Rutgers - New Jersey Medical School,
Newark, NJ; 2University Hospital, Newark, NJ *CR
3931 — A0217 An internal review comparing
the reliability indices of Humphrey visual fields
at our various facilities. Daniel Malach, J. Tannir,
B. A. Hughes, R. Swendris, A. Shukairy, C. Kim.
Kresge Eye Institute, Wayne State University
School of Medicine, Detroit, MI
3932 — A0218 Comparison of Compass and
Humphrey perimeters in detecting glaucomatous
defects. Paolo Fogagnolo1, A. Modarelli1, M.
Digiuni1, G. Montesano1, F. Oddone2, N. Orzalesi1,
L. Rossetti1.1Dipartimento Testa-Collo, San Paolo
Hospital, University of Milan, Italy, Milan, Italy;
2
GB Bietti Foundation, Rome, Italy *CR, f
3933 — A0219 Comparison of two strategies to
calculate perimetric sensitivity with the Compass
perimeter. Luca Rossetti, P. Fogagnolo, M.
Digiuni, A. Modarelli, G. Montesano. Dipartimento
Testa-Collo, San Paolo Hospital, University of
Milan, Milano, Italy *CR
3934 — A0220 Normal threshold size of stimuli
in children using a game-based visual field test.
Yanfang Wang1, 2, Z. Ali2, 1, T. Robinson3, S. Shakir2, 1,
T. Fernandes1, S. Biswas2, 1, C. Fenerty2, 1, D.
Henson1, 2, T. Aslam2, 1. 1University of Manchester,
Manchester, United Kingdom; 2Manchester Royal
Eye Hospital, Manchester, United Kingdom; 3None,
Manchester, United Kingdom
3935 — A0221 OPTIC study: Feasibility
and reliability of perimetry in children with
glaucoma. Dipesh E. Patel1, 2, B. C. Walters4, 5, I.
Russell-Eggitt1, 5, J. S. Rahi1, 3, P. Cumberland1, 5.
1
Life Course Epidemiology and Biostatistics
Section, UCL Institute of Child Health, London,
United Kingdom; 2Moorfields Eye Hospital,
London, United Kingdom; 3UCL Institute of
Ophthalmology, London, United Kingdom; 4Great
Ormond Street Hospital, London, United Kingdom;
5
Ulverscroft Vision Research Group, London,
United Kingdom
3936 — A0222 Clinical validation of a tablet
perimeter. Algis J. Vingrys1, J. K. Healey1, S.
Liew1, V. Saharinen1, M. Tran1, W. Wu1, Y. X. Kong2.
1
Optometry & Vision Sciences, University of
Melbourne, Melbourne, VIC, Australia; 2Centre of
Eye Research Australia, Melbourne, VIC, Australia
*CR
3937 — A0223 Development of a LED-Based
Visual Field System: Comparison with Standard
Automated Perimetry. Jaheon Kang. Department
of Ophthalmology, Kyung Hee University Hospital
at Gangdong, Seoul, Korea (the Republic of)
3938 — A0224 Spatial Interpolation Enables
Normative Data Comparison in Gaze-Contingent
Perimetry. Jonathan Denniss, A. Astle. School of
Psychology, University of Nottingham, Nottingham,
United Kingdom
3939 — A0225 Effectiveness of tracking
function of imo®, a head-mount type perimeter.
Takuya Numata1, C. Matsumoto1, S. Yamao1, H.
Nomoto1, F. Tanabe1, S. Hashimoto1, S. Okuyama1,
Y. Shimomura1, M. Aihara2, S. Kimura3, K.
Yamanaka3. 1Kinki Univ Faculty of Medicine,
Osaka-Sayama City, Japan; 2The University of
Tokyo, Bunkyou-ku, Japan; 3CREWT Medical
Systems, Tokyo, Japan *CR
3940 — A0226 The nGoggle: A Portable
Brain-Based Method for Assessment of Visual
Function Deficits in Glaucoma. Felipe A.
Medeiros1, J. K. Zao1, Y. Wang1, M. Nakanishi1,
Y. Lin1, A. Diniz-Filho1, T. Jung2. 1Laboratory of
Performance and Visual Function, University of
California San Diego, La Jolla, CA; 2Swartz Center
for Computational Neuroscience, University of
California San Diego, San Diego, CA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
268
Tuesday – Posters – 3941 – 3959
3941 — A0227 Temporal Contrast Sensitivities
are Locally Reduced around 4Hz for L-coneand around 10Hz for M-cone isolating stimuli
in Glaucoma Patients. Cord R. Huchzermeyer,
S. Haubner, R. Laemmer, C. Y. Mardin, J. J.
Kremers. Department of Ophthalmology, FriedrichAlexander-University Erlangen-Nürnberg,
Erlangen, Germany
3942 — A0228 Shape discrimination in
glaucoma. Graeme J. Kennedy, G. Loffler.
Department of Life Sciences, Glasgow Caledonian
University, Glasgow, United Kingdom
3943 — A0229 Evaluation of pattern ERG
responses using various electrodes. Anna
Shengelia1, P. H. Derr2, C. Tello1. 12Manhattan
Eye, Ear and Throat Hospital, Hofstra North ShoreLIJ School of Medicine, Hempstead, New York,
New York, NY; 2Diopsys, East Windzor, NJ *CR
3944 — A0230 Comparison of pattern ERG to
structural and functional change in subjects with
suspected glaucoma. Annahita Amireskandari, D.
Mantopoulos, F. M. Kapetansky, M. A. Slabaugh.
Ophthalmology, Ohio State University, Columbus, OH
3945 — A0231 Repeated-Patteren
Electroretinography, a new procedure for
electrophysiological diagnosis of glaucoma that
may improve Patteren Electroretinography
specificity. Nicola Cardascia1, A. Maviglio2, D.
Sisto1, P. Ferreri1, G. Alessio1. 1Ophthalmology,
Policlinico Bari Univ di Bari A Moro, Rutigliano,
Italy; 2Ophthalmology, ASL Brindisi, Mesagne,
Italy
3947 — A0233 Electrophysiological function of
intrinsically photosensitive retinal ganglion cells
severely impaired in glaucoma patients. Manami
Kuze1, M. Ayaki2, K. Tsubota2, M. Kondo1, T.
Morita3.1Ophthalmology, Mie University Graduate
School of Medicine, Matsusaka, Japan; 2Department
of Ophthalmology, Keio University School of
Medicine, Shinjyuku, Japan; 3International College
of Arts and Sciences Department of Environmental
Science, Fukuoka Women’s University, Fukuoka,
Japan
3948 — A0234 Next generation PERG
system and method for human studies. Pedro
F. Monsalve1, G. Triolo1, 3, J. Toft-NIelsen4, R.
Delgado4, E. Miskiel4, J. Bohorquez2, O. Ozcan2, W.
J. Feuer1, V. Porciatti1. 1Ophthalmology, Bascom
Palmer Eye institute, Miami, FL; 2Biomedical
Engineering, University of Miami, MIami, FL;
3
Ophthalmology, University Scientific Institute San
Raffaele, Milan, Italy; 4Intelligent Hearing System
Corp., Miami, FL *CR
3950 — A0236 RETeval in Patients with
Glaucoma and/or Diabetes. Victor Chen1, D. B.
Kim3, S. E. Brodie4, G. Wu2. 1UC San Diego, San
Jose, CA; 2Ophthalmology, UC San Francisco
School of Medicine, San Francisco, CA; 3UC
Berkeley, Berkeley, CA; 4Ophthalmolgy, Icahn
School of Medicine at Mt. Sinai, New York, NY
3951 — A0237 Visual and Auditory Induced
Event-Related Brain Dynamics in Glaucoma.
Masaki Nakanishi1, 2, A. Diniz-Filho1, E. R. Boer1, A.
Elhosseiny1, T. Jung2, F. A. Medeiros1. 1Laboratory
of Performance and Visual Function, University of
California San Diego, La Jolla, CA; 2Swartz Center
for Computational Neuroscience, University of
California San Diego, La Jolla, CA *CR
Exhibit/Poster Hall B0089-B0106
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Visual Psychophysics/Physiological Optics
376 Accommodation
Moderator: Mary Ann Croft
3952 — B0089 Does dynamic accommodation
respond to the shape of the blurred retinal
image without changes in physical vergence?
Ivan Marin-Franch1, 2, P. Bernal-Molina1, 2, A. J.
Del Águila-Carrasco1, 2, P. B. Kruger3, J. EsteveTaboada1, R. Montés-Micó1, N. Lopez-Gil2.
1
Departamento de Óptica y Optometría y Ciencias
de la Visión, Universitat de València, Burjassot,
Spain; 2Ciencias de la Visión research group,
Facultad de Óptica y Optometría, Universidad de
Murcia, Murcia, Spain; 3College of Optometry,
State University of New York, New York, NY
3953 — B0090 Determination of porcine
ciliary muscle contractility to adapt innovative
lens replacement materials. Thomas Stahnke1,
T. Noack2, R. Patejdl2, S. Hartleib2, A. Wree3, O.
Stachs1, N. Grabow4, R. Guthoff4. 1Department
of Ophthalmology, Rostock University Medical
Center, Rostock, Germany; 2Department of
Physiology, Rostock University Medical Center,
Rostock, Germany; 3Institute of Anatomy, Rostock
University Medical Center, Rostock, Germany;
4
Institute of Biomedical Engineering, Rostock
University Medical Center, Rostock, Germany
3954 — B0091 Effect of phenylephrine on static
and dynamic accommodation. Paula BernalMolina1, 2, A. J. Del Águila-Carrasco1, 2, N. LopezGil2, F. Lara2, P. B. Kruger3, R. Riquelme-Nicolás2,
R. Montés-Micó1, J. Esteve-Taboada1, I. MarinFranch1, 2. 1Universidad de Valencia, Burjassot,
Spain; 2Universidad de Murcia, Murcia, Spain;
3
State University of New York, New York, NY
3955 — B0092 Defining the Nyquist Sampling
limit for Dynamic Accommodation. Vivek
Labhishetty, W. R. Bobier, V. Lakshminarayanan.
School of Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada
3956 — B0093 Accommodative Accuracy and
Stability In Passive and Active Viewing Tasks in
Children with Uncorrected Hyperopia. Tawna
L. Roberts1, 2, J. S. Benoit2, 3, R. E. Manny2, S. B.
Stevenson2, H. A. Anderson2. 1Ophthalmology,
Akron Children’s Hospital, Akron, OH; 2University
of Houston College of Optometry, Houston, TX;
3
University of Houston TIMES Institute, Houston, TX
3957 — B0094 On the usefulness of Badal
optometer to stimulate accommodation. Mikel
Aldaba1, 2, J. Pujol1, 2, C. Otero1, 2. 1Centre for
Sensors, Instruments and Systems Development,
Universitat Politècnica de Catalunya, Terrassa,
Spain; 2Davalor Research Center, Universitat
Politècnica de Catalunya, Terrassa, Spain *CR
3958 — B0095 Retinal blood vessels may be
used to detect the sign of defocus. Norberto
Lopez-Gil1, M. T. Jaskulski1, F. Vargas-Martin1,
P. B. Kruger2. 1Physics, Universidad de Murcia,
Murcia, Spain; 2State University of New York
(SUNY), New York, NY
3959 — B0096 OCT Biometry of
the Crystalline Lens during Dynamic
Accommodation. Siobhan Williams1, 2, M.
Ruggeri1, 2, F. Manns1, 2, G. Gregori3, Y. Chang1, 2,
S. H. Yoo3, J. A. Parel1, 4. 1Ophthalmic Biophysics
Center, Bascom Palmer Eye Institute, University
of Miami Miller School of Medicine, Miami,
FL; 2Biomedical Optics and Laser Laboratory,
Department of Biomedical Engineering, University
of Miami College of Engineering, Miami, FL;
3
Bascom Palmer Eye Institute, University of Miami
Miller School of Medicine, Miami, FL; 4Vision
Cooperative Research Centre, Sydney, NSW,
Australia *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
269
Tuesday Posters
3:45 pm – 5:30 pm
3946 — A0232 Steady-State Pattern
Electroretinogram and Transient Visual Evoked
Potentials Analysis in Glaucomatous and Healthy
Eyes. Michael Waisbourd, A. Resende, A. Dilru, S.
Puri, M. Moster, L. A. Hark, L. Katz, A. Mantravadi.
Ophthalmology, Wills Eye Hospital, Philadelphia,
PA *CR, f
3949 — A0235 Repeatability of Steady-State
Pattern Electroretinogram and Full-Field
Electroretinogram using a novel office-based
testing platform in normal subjects. Arthur
Resende, M. Waisbourd, L. A. Hark, A. Mantravadi,
L. Katz. Ophthalmology, Wills Eye Hospital,
Philadelphia, PA *CR, f
3960 – 3977 – Tuesday – Posters
3960 — B0097 Dynamic Interaction of the
Ciliary Muscle and Crystalline Lens during
Accommodation evaluated with SD-OCT. Marco
Ruggeri1, C. De Freitas1, S. Williams1, 2, V. M.
Hernandez1, 2, F. Cabot1, 3, K. Alawa1, Y. Chang1, 2,
G. Gregori4, S. H. Yoo1, 3, J. A. Parel1, 5, F. Manns1, 2.
1
Ophthalmic Biophysics Center, Bascom Palmer
Eye Institute, University of Miami Miller School
of Medicine, Miami, FL; 2Biomedical Optics and
Laser Laboratory, Department of Biomedical
Engineering, University of Miami, College of
Engineering, Coral Gables, FL; 3Anne Bates
Leach Eye Hospital, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 4Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 5Brien Holden Vision Institute and
Vision Cooperative Research Centre, Sydney, NSW,
Australia *CR
3961 — B0098 Axial length and dynamic
disaccommodation changes accompanying
prolonged near work. Yilei Shao, J. Ye, Y. Yuan, S.
huang, M. Shen, F. Lu. School of Ophthalmology &
Optometry, Wenzhou Medical University, Wenzhou,
China
Tuesday Posters
3:45 pm – 5:30 pm
3962 — B0099 Near work-induced transient
myopia after short near work duration among
Malay adults. Azmir Ahmad1, 2, A. Chen2.
1
Optometry, Faculty of Health Sciences, Universiti
Teknologi MARA (UiTM), Puncak Alam, Malaysia;
2
iROViS, Health and Wellbeing CORE, Research
Mangement Center (RMC), Universiti Teknologi
MARA (UiTM), Shah Alam, 40460, Malaysia
3963 — B0100 Static and Dynamic
Accommodation and Pupil Responses of Early
Presbyopes Viewing through Monovision
Corrections. Meznah S. Almutairi, B. Altoaimi,
A. Bradley. Optometry, Indiana University,
Bloomington, IN
3964 — B0101 Dynamic Changes of
the Internal Structure of the Lens with
Accommodation. Yu-Cherng Chang1, 2, M.
Ruggeri1, 2, K. George3, S. H. Yoo3, J. A. Parel1, 4, F.
Manns1, 2. 1Ophthalmic Biophysics Center, Bascom
Palmer Eye Institute, University of Miami Miller
School of Medicine, Miami, FL; 2Biomedical Optics
and Laser Laboratory, Department of Biomedical
Engineering, University of Miami College of
Engineering, Coral Gables, FL; 3Anne Bates
Leach Eye Hospital, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 4Vision Cooperative Research Centre,
Sydney, NSW, Australia *CR
3965 — B0102 Heritability of ocular
dimensions and geometry in humans. Antonio
Benito1, J. Tabernero1, L. Hervella1, J. F. SánchezRomera2, J. R. Ordoñana2, M. Ruiz-Sánchez3,
J. M. Marín3, P. Artal1.1Laboratorio de Óptica,
Universidad de Murcia, Murcia, Spain; 2Murcia
Twin Registry, Area of Psychobiology, Murcia,
Spain; 3Hospital Universitario Arrixaca,
Murcia, Spain
3966 — B0103 3D Cinema And Visual
Discomfort. Christine Tanguy1, C. Hugny
Larroque1, S. Ferragut2, M. Lamard2, B.
Cochener1, 2. 1Ophtalmologie, Chu Morvan, Brest,
France; 2LATIM, Brest, France
3967 — B0104 Study of accommodative
function examination to assess visual fatigue
induced by watching 3D video. Li Zhang, L. Xu,
J. Li, S. Zhao. Ophthalmology, Beijing Tongren
Hospital, Beijing Institute of Ophthalmology,
Beijing, China
3968 — B0105 Accommodation response to
step changes in disparity vergence when viewing
stereoscopic displays. Ana Fernandez, D. Seidel,
L. E. Sweeney, L. Gray. Vision Sciences, Glasgow
Caledonian University, Glasgow, United Kingdom
3969 — B0106 Changes in visual function,
ocular biometry and dry eye in naïve diabetic
patients after euglycemic control. Karim
Mohamed-Noriega1, G. Gonzalez-Saldivar1, J.
González-González2, R. Rodriguez-Gutiérrez2, J.
Mohamed-Noriega1, H. Cavazos1, G. Villarreal
Méndez1, J. H. Gonzalez1, E. Cuervo-Lozano1, J.
Mohamed-Hamsho1. 1Dpto. Oftalmologia, Hospital
Universitario, Facultad de Medicina, Universidad
Autonoma de Nuevo Leon, Monterrey, Mexico;
2
Endocrinology, Hospital Universitario “Dr. José E.
Gonzalez”, Universidad Autónoma de Nuevo León,
Monterrey, Mexico
Exhibit/Poster Hall B0137-B0152
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Clinical/Epidemiologic Research
377 Clinical Aspects of Refractive Error
Moderator: Robert Wojciechowski
3970 — B0137 Effectiveness of Low-Cost
Glasses Distribution in the USA, Guatemala,
Ghana, Cambodia, Peru and the Dominican
Republic. Laetitia Truong1, B. Briggs3, L. Weiner1,
N. Mamdani2, O. Kosoko-Lasaki1, 3. 1Creighton
University School of Medicine, Omaha, NE;
2
First Sight,LLC, Omaha, NE; 3Health Sciences
Multicultural and Community Affairs, Creighton
University, Omaha, NE
3971 — B0138 Disparities in eyeglass insurance
coverage in Canada. Gordon Ngo1, G. E. Trope3, Y.
M. Buys2, Y. Jin2. 1Medicine, University of Western
Ontario, London, ON, Canada; 2Ophthalmology and
Vision Sciences, University of Toronto, Toronto,
ON, Canada; 3Cell Biology, University of Toronto,
Toronto, ON, Canada
3972 — B0139 Spectacle use in a rural
population in the state of Telangana in South
India. Srinivas Marmamula, R. Challa, E. K, R. C.
Khanna. GPR ICARE, L V Prasad Eye Institute,
Hyderabad, India
3973 — B0140 Spectacle Coverage in Older
Adults from Parintins: The Brazilian Amazon
Region Eye Survey (BARES). Galton C.
Vasconcelos6, 1, N. N. Cavascan1, A. Berezovsky1,
C. C. Cunha1, S. Munoz2, J. M. Furtado3, J.
M. Cohen4, M. J. Cohen5, R. Belfort1, S. R.
Salomao1. 1Departamento de Oftalmologia e
Ciências Visuais, Escola Paulista de Medicina,
Universidade Federal de São, São Paulo, Brazil;
2
Departamento de Salud Publica, Universidad de
La Frontera., Temuco, Chile; 3Departamento de
Oftalmologia, Otorrinolaringologia e Cirurgia
de Cabeça e Pescoço, Faculdade de Medicina
de Ribeirão Preto USP, Ribeirão Preto, Brazil;
4
Divisão de Oftalmologia, Departamento de
Cirurgia, Faculdade de Medicina, Universidade
Federal do Amazonas, Manaus, Brazil; 5Instituto de
Olhos de Manaus, Manaus, Brazil; 6Oftalmologia
e Otorrinolaringologia, Universidade Federal de
Minas Gerais UFMG, Belo Horizonte, Brazil
3974 — B0141 Prevalence of refractive
errors in a large German cohort of children
and adolescents. Heike Lange1, 2, M. Vogel2, A.
Ohlendorf3, S. Wahl3, P. M. Wiedemann1, W. Kiess2, 4,
F. G. Rauscher1.1Department of Ophthalmology,
University Hospital Leipzig, Leipzig, Germany;
2
Leipzig Research Centre for Civilization Diseases
-LIFE, Faculty of Medicine, University of Leipzig,
Leipzig, Germany; 3Institute for Ophthalmic
Research, University Tübingen, Tübingen,
Germany; 4Centre of Paediatric Research, Hospital
for Children and Adolescents, University of
Leipzig, Leipzig, Germany *CR
3975 — B0142 Longitudinal changes in
refractive error in Korean children. Young Shin
Kim, S. Park. Ophthalmology, Soonchunhyang
University Seoul Hospital, Seoul, Korea (the
Republic of)
3976 — B0143 National Eye Survey of Trinidad
and Tobago: the prevalence and risk factors
for refractive error. Shivaa S. Ramsewak5, N.
Verlander4, F. Deomansingh3, A. Fraser3, V.
Maharaj3, S. Sharma3, D. Singh2, R. R. Bourne1, T.
Braithwaite1. 1Vision and Eye Research Unit, Anglia
Ruskin University, Cambridge, United Kingdom;
2
Caribbean Eye Institute, Valsayn, Trinidad and
Tobago; 3Department of Optometry, University
of the West Indies, Saint Augustine, Trinidad and
Tobago; 4Public Health England, London, United
Kingdom; 5London School of Hygiene and Tropical
Medicine, London, United Kingdom
3977 — B0144 Familial Concordance
of Refractive Errors in Korean Children:
The Korea National Health and Nutrition
Examination Survey 2008-2012. Dong Hui
Lim1, 2, T. Chung1, J. Han3, S. Nam1, H. Yim2.
1
Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Korea (the Republic of); 2Preventive
Medicine, Graduate School, College of Medicine,
The Catholic University of Korea, Seoul, Korea (the
Republic of); 3Ophthalmology, Myongji Hospital,
Seoul, Korea (the Republic of)
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
270
Tuesday – Posters – 3978 – 3996
3978 — B0145 Comparison of refractive
error measurements in adults obtained by
autorefraction and subjective refraction. Prateek
Gajwani, L. I. Mudie, D. Zhao, C. Ogega, E.
Johnson, D. S. Friedman. Wilmer Eye Institute,
Baltimore, MD
3979 — B0146 Prevalence of myopia and
astigmatism in adults in Germany. Arne
Ohlendorf1, 2, H. Lange3, 4, M. Vogel4, S. Wahl1, 2,
P. M. Wiedemann3, W. Kiess4, 5, F. G. Rauscher3.
1
Carl Zeiss Vision International GmbH, Technology
& Innovation, Aalen, Germany; 2University
Tuebingen, Institute for Ophthalmic Research,
Tuebingen, Germany; 3University Hospital Leipzig,
Department of Ophthalmology, Leipzig, Germany;
4
Faculty of Medicine, Leipzig Research Centre for
Civilization Diseases - LIFE, Leipzig, Germany;
5
Hospital for Children and Adolescents, Centre of
Paediatric Research, Leipzig, Germany *CR
3980 — B0147 Posterior corneal shape
following gain or loss of keratometric
astigmatism. Joseph M. Miller1, 2, M. W. Belin1, E.
M. Harvey1, 2. 1Ophthalmology and Vision Science,
University of Arizona, Tucson, AZ; 2College of Public
Health, University of Arizona, Tucson, AZ *CR
3982 — B0149 Longitudinal changes of
Astigmatism in School-aged Children. Lili Wang1,
X. Guo1, X. Ding1, M. He1, 2. 1State Key Laboratory
of Ophthalmology, Zhongshan Ophthalmic Center,
Sun Yat-sen University, Guangzhou, China;
2
Centre for Eye Research Australia, University of
Melbourne, Melbourne, VIC, Australia
3983 — B0150 Distribution of mean refractive
error for London 2012 competitors and support
teams. Manbir Nagra1, C. Wilson2, S. Ceccon1,
W. D. Thomson1, P. J. D’Ath1. 1Division of
Optometry and Visual Science, City University
London, London, United Kingdom; 2Chelsea and
Westminster Hospital NHS Foundation Trust,
London, United Kingdom
Exhibit/Poster Hall B0164-B0174
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Nanotechnology and Regenerative Medicine
Group
378 Ocular pharmacological
and biological applications of
nanotechnology
Moderators: Christine F. Wildsoet and T
homas A. Fuchsluger
3986 — B0164 Controlled vancomycin
release from biodegradable nanoparticles.
Emily Dosmar1, J. J. Kang-Mieler1, W. F. Mieler2.
1
Biomedical Engineering, Illinois Institute
of Technology, Chicago, IL;2Department of
Ophthalmology and Visual Sciences, University of
Illinois at Chicago, Chicago, IL
3987 — B0165 Efficacy and dose dependent
response of intravenous dendrimertriamcinolone acetonide conjugates in CNV
suppression. Siva Pramodh Kambhampati1, 2,
I. A. Bhutto1, K. Ho1, G. A. Lutty1, 2, K.
Rangaramanujam1, 2. 1Wilmer Eye Institute
-Ophthalmology, Johns Hopkins School
of Medicine, Baltimore, MD; 2Center for
Nanomedicine, Johns Hopkins School of Medicine,
Baltimore, MD
3988 — B0166 Novel polymer-based
mucoadhesive and degradable nanoparticles
for delivery of ophthalmic drugs. Nicole
Mangiacotte1, G. Prosperi-Porta2, M. Jamard1,
L. Liu1, H. Sheardown1. 1Chemical Engineering,
McMaster University, Hamilton, ON, Canada;
2
Cumming School of Medicine, University of
Calgary, Calgary, AB, Canada
3989 — B0167 Study on the effect of size of
nanocarriers on trans-scleral transport. Rini R.
Joseph2, T. T. Wong1, 3, S. Venkatraman2. 1Singapore
National Eye Centre, Singapore, Singapore,
Singapore; 2Materials Science and Engineering,
Nanyang Technological University, Singapore,
Singapore; 3Ocular Drug Delivery Group, Singapore
Eye Research Institute, Singapore, Singapore
3990 — B0168 Mucoadhesive nanoparticle eye
drop platform: tracking of ocular retention and
treatment of experimental dry eye. Shengyan Liu1,
M. Dozois1, C. Chang1, D. Hileeto2, H. Liang3, 4,
M. Reyad3, 4, S. R. Boyd3, 4, L. W. Jones2, F. Gu1.
1
Chemical Engineering, University of Waterloo,
Waterloo, ON, Canada; 2Centre for Contact Lens
Research, University of Waterloo, Waterloo, ON,
Canada; 3Keenan Research Centre for BIomedical
Science, St. Michael’s Hospital, Toronto, ON,
Canada; 4Department of Opthalmology & Vision
Sciences, University of Toronto, Toronto, ON,
Canada *CR
3991 — B0169 Evaluation of Antioxidant
Catalase in Sodium Hyaluronate-albuminchitosan microparticles for inhibition of
LPS-induced ROS in Ex-vivo models of
choroidal neovascularization. Rodney C. Siwale.
Pharmaceutical Sciences, Western New England
University College of Pharmacy, Springfield, MA
3992 — B0170 Release of Avastin from
laser-stimulated nanocarriers. Lauren M.
Wright1, A. Catala2, K. L. Nash2, R. D. Glickman1.
1
Ophthalmology, Univ. of Texas Hlth. Sci. Ctr., San
Antonio, TX; 2Physics & Astronomy, Univ. Texas
San Antonio, San Antonio, TX
3993 — B0171 Nanoparticle Mediated Efficient
Treatment Strategy for Photocoagulation of
Retinal and Choroidal Neovascularization
of Diabetic Retinopathy. Rupesh Singh, M.
Balasubramanian. Electrical and Computer
Engineering, University of Memphis, Memphis,
TN *CR
3994 — B0172 Targeted Delivery of
YSA-Functionalized PLGA Nanoparticles
to Endothelial Cells. Arun K. Upadhyay1,
T. Carpenter2, E. Grayck2, U. B. Kompella1.
1
Department of Pharmaceutical Sciences, University
of Colorado Denver, Aurora, CO; 2Pediatric Critical
Care Medicine, University of Colorado Denver,
Aurora, CO
3995 — B0173 Magnetic Hyperthermia
Treatment in Y-79 Retinoblastoma and ARPE19 RPE Cells: Concentration Dependent Effect
of Iron Oxide Nanoparticle. Naziha Slimani1,
M. D. Pawar1, Z. Gursel Ozkurt1, R. Tucker2, P.
Vaishnava2, C. G. Besirli1, H. Demirci1. 1kellogg eye
center, Canton, MI; 2kettering university, Flint, MI
3996 — B0174 Long Term Culture of Human
Lens Tissue for Screening Drugs with the
Potential to Prevent PCO. Jacquelyn V. Gerhart1,
M. Greenbaum2, R. Getts1, M. George-Weinstein3.
1
Genisphere, LLC, Hatfield, PA; 2Lankenau Medical
Center, Wynnewood, PA; 3Cooper Medical School
of Rowan University, Camden, NJ *CR
3984 — B0151 Refractive Error & Academic
Achievement. Lesley Doyle, S. McCullough, K.
Saunders. School of Biomedical Sciences, Ulster
University, Coleraine, United Kingdom
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
271
Tuesday Posters
3:45 pm – 5:30 pm
3981 — B0148 Total, corneal and ocular
residual astigmatism: Distribution in a German
population and age-dependency - The Gutenberg
Health Study. Alexander K. Schuster1, N. Pfeiffer1,
A. Schulz2, R. Hoehn1, 3, K. A. Ponto1, 4, M. Blettner5,
P. S. Wild2, 4, A. Mirshahi1, 6. 1University Medical
Center Mainz, Department of Ophthalmology,
Mainz, Germany; 2Preventive Cardiology and
Preventive Medicine / Center for Cardiology,
University Medical Center Mainz, Mainz, Germany;
3
Department of Ophthalmology, Inselspital,
Bern, Switzerland; 4Center for Thrombosis
and Hemostasis (CTH), University Medical
Center, Mainz, Germany; 5Institute for Medical
Biostatistics, Epidemiology and Informatics,
University Medical Center Mainz, Mainz, Germany;
6
Dardenne Eye Clinics, Bonn, Germany
3985 — B0152 Prevalence of refractive errors
and self-reported near-work, indoor and outdoor
activities in Norwegian adolescents. Jon V. B.
Gjelle, L. A. Hagen, S. Arnegard, S. J. Gilson, R. C.
Baraas. Optometry and Visual Science, University
College of Southeast Norway, Kongsberg, Norway
3996 – 4016 – Tuesday – Posters
Exhibit/Poster Hall B0175-B0219
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Physiology/Pharmacology / Eye Movements/
Strabismus/Amblyopia/Neuro-Ophthalmology /
Low Vision / Multidisciplinary Ophthalmic
Imaging / Retinal Cell Biology / Retina /
Visual Neuroscience
379 Drug Delivery
Moderators: Vatinee Y. Bunya and Antonino Asero
Tuesday Posters
3:45 pm – 5:30 pm
3997 — B0175 SHP2 (PTPN11) over-expression
by AAV gene delivery impairs neuronal
cell growth in SH-SY5Y cells and induces
neurodegeneration of SD rat retinal ganglion
cells. Nitin Chitranshi1, V. Gupta1, R. Vanderwall1,
Y. Dheer1, S. L. Graham1, 2. 1Macquarie University,
Sydney, NSW, Australia; 2University of Sydney,
Save Sight Institute, Sydney, NSW, Australia
3998 — B0176 Effect of Conjunctival Ring
with Dexamethasone Sodium Phosphate on
Rabbit VEGF-induced Blood-Retinal Barrier
Breakdown. Hiroaki Takahashi1, W. Asayama1, H.
Obata2, T. Matsunaga2, A. Kanda3, 4, K. Noda3, 4, S.
Ishida3, 4. 1Research & Development Division, Senju
Pharmaceutical Co., Ltd., Kobe, Japan; 2Research
& Development Division, SEED Co., Ltd., Saitama,
Japan; 3Laboratory of Ocular Cell Biology and
Visual Science, Hokkaido University Graduate
School of Medicine, Sapporo, Japan; 4Department
of Ophthalmology, Hokkaido University Graduate
School of Medicine, Sapporo, Japan *CR
3999 — B0177 Fabrication and
characterisation of implants for intraocular
delivery of triamcinolone acetonide. Kathryn
McAvoy, D. Jones, R. Thakur. Pharmacy, Queens
University Belfast, Belfast, United Kingdom
4000 — B0178 Eye Drop Adherence
Following Retina Surgery. Daniel Glasser1, S.
Charoenthongtrakul1, H. Wafapoor1, R. L. Avery2,
A. M. Eaton1. 1Research, Retina Health Center, Fort
Myers, FL; 2California Retina Consultants, Santa
Barbara, CA *CR
4001 — B0179 Morphological and
electrophysiological study of the effects of
intravitreal mycophenolic acid in a model of
experimental chronic uveitis in rabbits. Andre
M. Liber1, G. L. Ioshimoto1, T. Z. Igami1, A. SilvaCunha2, B. V. Nagy1, M. F. Costa1, F. M. Damico1,
D. F. Ventura1. 1Ophthalmology, Universidade de
Sao Paulo, Sao Paulo, Brazil; 2Universidade Federal
de Minas Gerais, Belo Horizonte, Brazil
4002 — B0180 Pharmacokinetics Including
Ocular Distribution Characteristics of
Suprachoroidally Administered CLS011A in
Rabbits Could be Beneficial for a Wet AMD
Therapeutic Candidate. Jennifer Kissner1,
S. R. Patel1, J. J. Prusakiewicz2, D. Alton2, G.
Bikzhanova2, L. Geisler2, B. Burke1, G. Noronha1.
1
Clearside Biomedical, Inc, Alpharetta, GA;
2
Covance Laboratories, Inc, Madison, WI *CR
4003 — B0181 Factors affecting protein
aggregation for bevacizumab. Alexander T.
Nguyen, L. T. Tainsh, P. Coady, M. Ghiassi, L. J.
Rizzolo, R. A. Adelman. Ophthalmology and Visual
Sciences, Yale School of Medicine, New Haven, CT
4004 — B0182 Lens Capsule Biodegradable
Lipid Implant for Sustained-Release Anti-VEGF
Therapy of Neovascular AMD. Sarah Molokhia1,
R. M. Burr1, M. Flood2, M. Vallrath3, G. Winter3,
B. K. Ambati2, 1. 1Ophthalmology, iVeena, Salt
Lake City, UT; 2Moran Eye Center, Salt Lake City,
UT; 3Ludwig-Maximilians-Universität München,
Munich, Germany *CR
4005 — B0183 Novel modeling for the
Enhancement of Decision-Making Worthiness
of Ocular Pharmacokinetic Study Results.
Muhammad Abdulrazik. East Jerusalem Biomedical
Institute, East Jerusalem
4006 — B0184 Effect of a latanoprosteluting contact lens on IOP in glaucomatous
monkeys. J. B. Serle2, J. B. Ciolino1, 3, A. Ross1, 3,
R. Tulsan1, 3, R. Wang2, D. Kohane3, Janet B.
Serle2. 1Ophthalmology, Massachusetts eye and
ear infirmary, Boston, MA; 2Ophthalmology. Icahn
School of Medicine at Mount Sinai, New York, NY;
3
Anaesthesia, Boston Children’s Hospital, Boston,
MA *CR
4007 — B0185 The Preclinical Safety, Toxicity
and Pharmacokinetics (Pk) of Targeted
Episcleral Delivery of Topotecan (TPT),
Melphalan (MEL) and Its Combination with
Dexamethasone (DEX).Ricardo A. De Carvalho1, 4,
P. P. Ko1, 2, A. Murphree3, R. Brito1, J. Moreno1, P.
N. Wahjudi1, M. C. Vargas-Dougherty1, C. Mendes4,
G. C. Matsutani4, J. Manders1. 13T Ophthalmics,
Irvine, CA; 2Eye Care for Animals, San Diego,
CA; 3Childrens Hospital of Los Angeles, USC,
Los Angeles, CA; 43T Biopolymers, Sao Paulo,
Brazil *CR
4008 — B0186 An engineered porous silica
particle for sustained intravitreal delivery of
mycophenolic acid. Yuqin Wang2, 1, D. Warther2, K.
Huffman2, S. Rios2, D. Sengmany2, W. R. Freeman2,
M. Sailor3, L. Cheng2. 1Specialty of Uveitis, 2.
Eye Hospital of Zhejiang Province, School of
Ophthalmology and Optometry, Wenzhou Medical
University, Wenzhou, China; 2Department of
Ophthalmology, 1. Jacob’s Retina Center at Shiley
Eye Institute, University of California San Diego,
San Diego, CA; 3Department of Chemistry and
Biochemistry, University of California,
San Diego, CA *CR
4009 — B0187 Continuous Intravitreal AntiVEGF Delivery by Encapsulated Cell Technology
(ECT): Modeling of Disease Maintenance
in Patients with CNV Secondary to AMD.
Christian Landeros, M. Rivera, A. M. Lelis, L.
Orecchio, K. Kauper. Ophthalmology, Neurotech
Pharmaceuticals, Inc., Cumberland, RI *CR
4010 — B0188 Dexamethasone Degradation
During In Vitro Release from an Intravitreal
Implant. Brock Matter1, A. Ghaffari1, D.
Bourne1, Y. Wang2, S. Choi2, U. B. Kompella1.
1
Pharmaceutical Sciences, University of Colorado,
Aurora, CO; 2Center for Drug Evaluation and
Research, FDA, Silver Spring, MD
4011 — B0189 Sustained-release Drug-eluting
Microrods as Ocular Implants. Anthony Ng1, X.
Ng1, Y. Liu2, Y. Peng1, J. S. Mehta2, T. T. Wong2, 1,
S. Venkatraman1. 1School of Materials Science &
Engineering, Nanyang Technological University,
Singapore, Singapore; 2Singapore Eye Research
Institute, Singapore, Singapore
4012 — B0190 Cryopreservation as a Novel
Method for Encapsulated Cell Therapy
Packaging, Storage, and Distribution. Michael
Rivera, K. Kauper, J. Duggan, C. Landeros, L.
Orecchio, C. Cortellessa, A. M. Lelis. Neurotech
Pharmaceuticals, Inc., Cumberland, RI *CR
4013 — B0191 A 6-Week Toxicity and
Toxicokinetics Study of a Single Bilateral
Intracameral Administration of ENV905
(difluprednate) Ophthalmic Implant in New
Zealand White Rabbits. RiLee Robeson1, R. S.
Verhoeven1, A. Garcia1, P. Miller2, J. Miller3, T.
Navratil1, R. M. Schiffman1. 1Ophthalmology,
Envisia Therapeutics, Morrisville, NC; 2OSOD,
Madison, WI; 3Covance Laboratories, Madison, WI
*CR
4014 — B0192 Evaluation of the
Biocompatibility of a New Dexamethasone
Implant in the Rabbit Eye (GLP study). Michael
M. Burr1, 2, S. Molokhia1, 2, B. Ambati1, 2. 1iVeena,
Salt Lake City, UT; 2Moran Eye Center, Salt Lake
City, UT *CR
4015 — B0193 Evaluation of a sustained release
formulation of bevacizumab. Sahar Awwad1, 2, A.
Al-Shohani1, 2, P. T. Khaw2, S. Brocchini1, 2. 1UCL,
School of Pharmacy, London, United Kingdom;
2
National Institute for Health Research (NIHR)
Biomedical Research Centre at Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom
4016 — B0194 Sustain release of genistein from
nanoparticles surface modified IOL by ester
bond to prevent posterior capsular opacification
in rabbit eyes. Jinlu Liu2, 1, B. Ambati1, J.
Kong2.1Ophthalmology, Moran eye center, Salt Lake
City, UT; 2Ophthalmology, The fourth Affiliated
Hospital of China Medical University,
Shenyang, China
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
272
Tuesday – Posters – 4017 – 4035
4017 — B0195 Protective Effects of Sustained
Unoprostone Release Device in Rhodopsin
Pro347Leu Transgenic Rabbits. Nobuhiro
Nagai2, Y. Izumida2, H. Kaji3, M. Nishizawa3, A.
Katsuyama2, S. Yamada2, T. Nakazawa1, M. Kondo4,
H. Terasaki5, Y. Mashima6, T. Abe2. 1Ophthalmology,
Tohoku University, Sendai, Japan; 2Tohoku
University Graduate School of Medicine, Sendai,
Japan; 3Graduate School of Engineering, Tohoku
University, Sendai, Japan; 4Mie Univ Graduate
School of Med, Mie, Japan; 5Nagoya Univ School
of Medicine, Nagoya, Japan; 6R-Tech Ueno,
Tokyo, Japan *CR
4018 — B0196 A Sustained Release
Formulation of Novel Quininib-Hyaluronic Acid
microneedles inhibits Angiogenesis and Retinal
Vascular Permeability in vivo. Orla M. Galvin1,
A. Srivastava2, O. Carroll2, R. Kulkarni3, S. Dykes3,
S. Vickers3, K. Dickinson3, R. Jones3, S. Cheetham3,
A. Pandit2, B. N. Kennedy1. 1The Conway Institute,
School of Biomolecular and Biomedical Science,
University College Dublin, Dublin, Ireland; 2Centre
for Research in Medical Devices, Bioscience
Building, National University of Ireland Galway,
Galway, Ireland; 3RenaSci Ltd, Nottingham,
United Kingdom *CR
4019 — B0197 Sustained release of DE-117 via
intracameral polycaprolactone glaucoma device.
Jean Kim1, M. Kudisch1, S. Mudumba2, H. Asada3,
E. Shibuya3, R. Bhisitkul1, T. Desai1. 1University
of California, San Francisco, San Francisco,
CA; 2Santen, Inc., Emeryville, CA; 3Santen
Pharmaceutical Co., Nara, Japan *CR
4021 — B0199 Treatment of Chronic
Allergic Conjunctivitis with Sustained Release
Dexamethasone Using a Modified Conjunctival
Allergen Challenge (Ora-CAC®) Model. Deepa
Mulani1, E. B. McLaurin2, C. Repke3, M. Sato4,
P. J. Gomes5, E. Ankerud1, M. Bassett6, C. D.
Blizzard6, A. Driscoll6, A. Sawhney6. 1Clinical,
Ocular Therapeutix Inc, Bedford, MA; 2Total Eye
Care, Memphis, TN; 3Philadelphia Eye Associates,
Philadelphia, PA; 4East West Eye Institute,
Los Angeles, CA; 5ORA, Andover, MA; 6Ocular
Therapeutix Inc, Bedford, MA *CR, f
4022 — B0200 Exosomes released from
ethanol-damaged RPE cells produce damage
in neighboring cells. Francisco J. Romero1, S.
Atienzar-Aroca1, G. Serrano2, N. Martinez1, L.
Vidal-Gil1, J. BArcia1, J. Sancho-Pelluz1. 1School
of Medicine, Universidad Católica de Valencia
San Vicente Mártir, Valencia, Spain; 2Complejo
Hospitalario de Albacete, Albacete, Spain
4024 — B0202 Spectral time sharing to
simultaneously measure rhodopsin absorbance
and retinol fluorescence while mitigating light
scatter in living frog retina suspensions. Gabriel
Gonzalez-Fernandez1, R. J. DeSa2. 1Ophthalmology,
University of Mississippi Medical Center, Jackson,
MS; 2Research & Development, Olis, Bogart, GA
*CR
4025 — B0203 rAAV8 biodistribution and
shedding after subretinal injection in nonhuman primates. Immanuel Philipp Seitz1, 2, M.
Fischer1, 2, S. Michalakis3, B. Wilhelm4, N. Kahle4,
E. Zrenner2, M. Ueffing2, K. Bartz-Schmidt1, 2, M.
Biel3, B. Wissinger2, T. Peters2. 1University Eye
Hospital Tübingen, Tübingen, Germany; 2Institute
for Ophthalmic Research, University of Tübingen,
Centre for Ophthalmology, Tübingen, Germany;
3
Center for Integrated Protein Science Munich
(CIPSM), Departement of Pharmacology, LudwigMaximilians-Universität München, Munich,
Germany; 4STZ eyetrial, University of Tübingen,
Centre for Ophthalmology, Tübingen, Germany
4026 — B0204 Ocular and systemic safety of a
HIV-1-derived lentiviral vector after subretinal
injection in Macaca fascicularis eyes. Corinne
Kostic1, A. Matet1, F. Mavilio2, S. Martin2, A.
Bemelmans3, F. F. Behar-Cohen1, Y. Arsenijevic1.
1
Dpt Ophthalmology, Jules-Gonin Eye Hosp, Univ
Lausanne, Lausanne, Switzerland; 2Genethon,
Evry, France; 3URA2210, CEA/CNRS, MirCEN,
Fontenay-les-Roses, France
4027 — B0205 Evaluation of efficacy of
liposomal triamcinolone acetonide as targeted
anti-inflammatory treatment in a rabbit model
of experimental uveitis. Chee Wai Wong1, 2, B.
Czarny3, S. Ng1, 2, V. A. Barathi2, B. Metselaar4, G.
Storm4, T. T. Wong1, 2. 1Ophthalmology, Singapore
National Eye Centre, Singapore, Singapore;
2
Singapore Eye Research Institute, Singapore,
Singapore; 3Department of Pharmacy, National
University of Singapore, Singapore, Singapore;
4
MIRA Institute for Biomedical Technology and
Technical Medicine, University of Twente,
Twente, Netherlands
4028 — B0206 Bioactivity Studies
Of Biodegradable GDNF/VitE Loaded
Microspheres In Organotypic Cultures Of
Neonatal Rat Retina. Rocio Herrero-Vanrell1, 2,
C. García-Caballero1, 2, B. Arango-González3,
I. Bravo-Osuna1, 2, M. Ueffing3. 1Pharmacy and
Pharmaceutical Technology, Faculty of Pharmacy,
Complutense University, Madrid, Spain; 2Red
Temática de Investigación Cooperativa Sanitaria en
Enfermedades Oculares OFTARED and Instituto
de Investigación Sanitaria del Hospital Clínico
San Carlos (IdISSC), Madrid, Spain; 3Institute for
Ophthalmic Research, University of Tübingen,
Tübingen, Germany
4029 — B0207 Sustained Release
Biodegradable Formulations for Intraocular
Delivery: Extended Release of Hydrophilic
APIs and Combination Products. Janet Tully,
M. Yang, M. Sandahl, S. Williams, R. Schiffman.
Ophthalmology, Envisia Therapeutics,
Moorisville, NC *CR
4030 — B0208 Electric field-mediated targeting
of drug delivery in the suprachoroidal space. Jae
Hwan Jung, B. Chiang, M. R. Prausnitz. Chemical
and Biomolecular Engineering, Georgia Institute of
Technology, Atlanta, GA
4031 — B0209 A Novel Biocompatible,
Membrane-Interactive Delivery System
for Administration of an Ophthalmic Antiinflammatory Drug. Kevin L. Ward1, K. S.
Crawford1, 2, M. Liu1, A. L. Cromwick1, S. P.
Barman1. 1Integral Biosystems LLC, Bedford, MA;
2
PharmOcu, Bedford, MA *CR
4032 — B0210 Determination of the
optimum delivery route for the intraglandular
administration of botulinum toxin A in patients
with refractory epiphora. Christina Y. Weng1,
E. Houle2, K. C. Oktavec3, J. Tian4, S. L. Merbs4.
1
Ophthalmology, Baylor College of MedicineCullen Eye Institute, Houston, TX; 2Ophthalmology,
University of Vermont, Burlington, VT;
3
Ophthalmology, Columbia University, New York,
NY; 4Ophthalmology, Johns Hopkins University,
Baltimore, MD f
4033 — B0211 Ultrahigh field MR - Imaging
of a polymeric Injectable Local Drug Delivery
System. Karen Falke1, T. Lindner3, S. Polei3, F.
Kopp2, T. Eickner2, T. Stahnke2, A. Jünemann1, O.
Stachs1, R. Guthoff2. 1Eye Deparment, University
of Rostock, Rostock, Germany; 2Institute for
Biomedical Engineering, University of Rostock,
Rostock, Germany; 3Core Facility Multimodal
Small Animal Imaging, Rudolf Zenker Institut
for Institute for Experimental Surgery, University
Medicine Rostock, Rostock, Germany
4034 — B0212 Targeted delivery of sFLT-MO
using cyclic RGD peptide suppresses laser CNV.
Hironori Uehara, S. K. Muddana, X. Zhang, A.
Bohner, B. Ambati. Ophthalmology, Moran Eye
Center, University of Utah, Salt Lake City, UT
4035 — B0213 Calixarene-based
nanoformulation for ocular delivery of
curcumin: in vitro and in vivo anti-inflammatory
activity evaluation. Anna Rita Blanco1, G.
Granata2, C. Geraci2, I. Paterniti3, E. Esposito3, S.
Cuzzocrea3, G. M. Consoli2. 1SIFI SpA, Lavinaio,
Italy; 2Institute of Biomolecular Chemistry,
National Research Council (CNR), Catania, Italy;
3
Department of Biological and Environmental
Sciences, University of Messina, Messina, Italy
*CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
273
Tuesday Posters
3:45 pm – 5:30 pm
4020 — B0198 Sustained Release of Travoprost
for Glaucoma Therapy via a Biodegradable
Wafer, NanoM-TP. Shikha P. Barman1, M. Liu1,
K. Crawford2, 1, K. Ward1. 1Drug Delivery, Integral
BioSystems, Bedford, MA; 2Preclinical, PharmOcu,
LLC, Andover, MA *CR
4023 — B0201 In vitro and In vivo Sustained
Release of Dexamethasone from a PRINT
Microparticle Suspension. Melissa Sandahl, M.
Hernandez, J. Tully, G. owens, R. S. Verhoeven,
R. Robeson, S. Williams, R. Schiffman. Envisia
Therapeutics, Inc, Morrisville, NC *CR
4036 – 4055 – Tuesday – Posters
4036 — B0214 In vivo fluorescence retinal
imaging following AAV2-mediated gene delivery
in the rat retina. Joo Yong Lee1, H. Lee2, J. Kim2.
1
Ophthalmology, Asan Medical Center, Seoul;
2
Department of Microbiology, Cellular Dysfunction
Research Center, Asan Medical Center, Seoul,
Korea (the Republic of)
4037 — B0215 Cell-penetrating peptides
as non-invasive drug delivery vehicles for
ranibizumab and bevacizumab. Felicity de
Cogan1, L. J. Hill1, P. Morgan-Warren1, M. Chen2,
R. Scott3, H. Xu2, A. Logan1.1Inflammation and
ageing, University of Birmingham, Birmingham,
United Kingdom; 2Queens University, Belfast,
United Kingdom; 3Moorfields Eye Hospital, Dubai,
United Arab Emirates
Tuesday Posters
3:45 pm – 5:30 pm
4038 — B0216 Utility of Commercially
Available Cationic Lipid-based Delivery of
CRISPR-Cas9 to the Retina in vivo. Sandy S.
Hung1, V. Chrysostomou4, H. Shen6, F. li2, A. E.
King2, J. G. Crowston4, A. Pébay1, B. V. Bui3,
G. Liu5, A. W. Hewitt7, 2. 1Neuroregeneration
Unit, Centre for Eye Research Australia, East
Melbourne, VIC, Australia; 2Menzies Institute
for Medical Research, Tasmania, TAS, Australia;
3
Optometry and Vision Sciences, University of
Melbourne, Melbourne, VIC, Australia; 4Glaucoma
Research Unit, Centre for Eye Research Australia,
Melbourne, VIC, Australia; 5Cytoprotection Unit,
Centre for Eye Research Australia, Melbourne, VIC,
Australia; 6Department of Microbiology, Monash
University, Melbourne, VIC, Australia; 7Clinical
Genetics Unit, Centre for Eye Research Australia,
Melbourne, VIC, Australia
4039 — B0217 A Biodegradable, SustainedReleased, Tacrolimus Microfilm Drug Delivery
System for the Management of Allergic
Conjunctivitis in a Mouse Model. Yu-Chi Liu1,
X. Ng3, H. Ang1, C. Lwin2, S. Venkatraman3, T.
T. Wong4, J. S. Mehta1. 1Cornea and External
Eye Disease, Singapore Eye Research Institute,
Singapore, Singapore; 2Singapore Eye Research
Institute, Singapore, Singapore; 3Nanyang
Technological University, Singapore, Singapore;
4
Singapore National Eye Centre, Singapore,
Singapore
4040 — B0218 Wolfram Syndrome murine
models: phenotyping and gene therapy. Jolanta
M. Jagodzinska1, 2, D. Bonnet-Wersinger1, S.
Koks3, B. Delprat1, 2, C. P. Hamel1, 4, C. DelettreCirballet1, 2.1Institute for Neurosciences of
Montpellier, INSERM, Montpellier, France;
2
Univeristy of Montpellier, Montpellier, France;
3
Institute of Biomedicine and Translational
Medicine, University of Tartu, Tartu, Estonia;
4
Ophthalmology, Hôpital Gui de Chauliac,
Montpellier, France
4041 — B0219 X-Linked Inhibitor of Apoptosis
Gene Therapy Protects Retinal Structure in a
Feline Model of Retinal Detachment. Sarah J.
Wassmer2, 1, B. C. Leonard3, 1, S. G. Coupland3, 1, J.
Hamilton1, A. N. Baker1, L. Fang1, 4, C. Tsilfidis2, 1.
1
Regenerative Medicine, Ottawa Hospital Research
Institute, Ottawa, ON, Canada; 2Cellular and
Molecular Medicine, University of Ottawa,
Ottawa, ON, Canada; 3Ophthalmology, University
of Ottawa Eye Institute, Ottawa, ON, Canada;
4
Ophthalmology, Fujian Medical University Union
Hospital, Fujian, China *CR
Exhibit/Poster Hall C0087-C0132
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Retina
380 Vitreoretinal Interface Disase
Moderator: Itay Chowers
4042 — C0087 Ocriplasmin in a porcine
model for PVD induction. Bart Jonckx, I.
Etienne, T. Janssens, J. H. Feyen. Ophthalmology,
ThromboGenics NV, LEUVEN, Belgium *CR
4043 — C0088 Repeated injections of
ocriplasmin in the Göttingen mini-pig. Jean
H. Feyen1, K. Tenneson2, M. Vezina2, B. Jonckx1.
1
Preclinical Research, ThromboGenics NV, Leuven,
Belgium; 2Ocular and Neuroscience, Charles River
Laboratories, Montreal, QC, Canada *CR
4044 — C0089 Preclinical insights into
ocriplasmin safety and mechanism of action.
Michaël PORCU, I. Etienne, A. Candi, A. Verborg,
M. Eelen, B. Jonckx, J. H. Feyen. Preclinical
Research, ThromboGenics NV, Leuven, Belgium
*CR
4045 — C0090 The ocriplasmin for
vitreomacular traction intravitreal injection
decisions (OVIID-I) trial: full study
results. Ramin Tadayoni1, D. C. Carr2, Z.
Zhao2. 1Ophthalmology, Hopital LariboisiereOphthalmologie, Paris, France; 2Pharmaceuticals,
Alcon Research, Ltd., Fort Worth, TX *CR, f
4046 — C0091 Pharmacologic Closure
Rate of Full Thickness Macular Hole
with Ocriplasmin—1 year follow-up data.
Priya Sharma1, E. Rahimy2, C. D. Regillo3.
1
Ophthalmology Residency, Wills Eye Hospital,
Philadelphia, PA; 2Vitreoretinal Fellowship, Wills
Eye Hospital, Philadelphia, PA; 3Midatlantic Retina,
Wills Eye Hospital, Philadelphia, PA *CR
4047 — C0092 Ocriplasmin for vitreo-macular
traction: a Wide-Field OCT Study. Chiara
Preziosa, I. D’Agostino, U. Nava, S. Erba, M. G.
Cereda, F. Bottoni, G. Staurenghi. Biomedical and
Clinical Sciences “Luigi Sacco”, Sacco Hospital,
Eye Clinic, University of Milan, Milan, Italy *CR
4048 — C0093 Acute Ocriplasmin Retinopathy
(AOR): Electroretinographic (ERG), SD-OCT
and clinical features of 6-months monitoring.
Katerina Hufendiek, K. Hufendiek, J. Brahms,
A. Bajor, C. Framme. University Eye Hospital,
Medical School Hannover, Hannover, Germany.,
Hannover, Germany
4049 — C0094 Clinical results of Ocriplasmin
versus C3F8 gas for symptomatic Vitreomacular
Traction Syndrome. Katherine Atkins, S. Taylor.
Ophthalmology, Royal Surrey County Hospital,
Guildford, United Kingdom
4050 — C0095 Evaluation of full-field
electroretinogram changes after ocriplasmin
injection in a substudy of symptomatic
vitreomacular adhesion subjects from the
OASIS trial. Joseph I. Markoff1, D. G. Birch2,
R. Sergott3, P. Kozma-Wiebe4. 1physiology,
Wills Eye Hospital, Moorestown, NJ; 2Retina
Foundation of the Southwest, Dallas, TX; 3NeuroOphthalmology, Wills Eye Hospital, Philadelphia,
PA; 4ThromboGenics, Leuven, Belgium *CR, f
4051 — C0096 Immune-histochemical
characteristics of idiopathic epiretinal
membranes. Inge Sarens1, R. Van Ginderdeuren1, 2,
P. Stalmans1, J. Van Calster1. 1Ophthalmology, UZ
Leuven, Leuven, Belgium;2Pathology, UZ Leuven,
Leuven, Belgium
4052 — C0097 Vitreous Biomarkers in
Idiopathic Epiretinal Membrane. Parisa Emaminaeini, P. Singh, J. D. Boss, A. Kumar, A. Tewari.
Ophthalmology, Kresge Eye Institute, Detroit, MI
4053 — C0098 Paravascular Inner Retinal
Defects Associated with Epiretinal Membranes.
Akitaka Tsujikawa1, Y. Miyoshi1, S. Manabe1, Y.
Nakano1, T. Fujita1, C. Shiragami1, K. Hirooka1,
A. Uji2, Y. Muraoka2. 1Ophthalmology, Kagawa
Univerisity Faculty of Medicine, Miki, Japan;
2
Ophthalmology and Visual Sciences, Kyoto
University Graduate School of Medicine, Kyoto,
Japan
4054 — C0099 Changes in Vitreomacular
Attachment with Aging: A Comparison Between
Healthy Patients and Diabetics. Brooke L.
Nesmith, A. C. Palacio, Y. Schaal, A. Gupta, S.
Schaal. Department of Ophthalmology and Visual
Sciences, University of Louisville, Louisville, KY
4055 — C0100 Characteristics of Epiretinal
Membrane Remnant Edge by Optical Coherence
Tomography after Pars Plana Vitrectomy. Raouf
Gaber, Q. You, M. Alam, I. Kilic, N. Mendoza, F.
Tsai, W. R. Freeman. Ophthalmology, University of
California San Diego, San Diego, CA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
274
Tuesday – Posters – 4056 – 4076
4056 — C0101 Prevalence of Metamorphopsia
in Patients with Vitreomacular Traction and its
Impact on Quality of Life: The MeMo Study.
Praveen J. Patel1, J. Brazier2, C. Hirneiss3, M.
Tangelder4, B. Lescrauwaet5. 1NIHR Biomedical
Centre at Moorfields Eye Hospital and UCL
Institute of Ophthalmology, London, United
Kingdom; 2Health Economics and Decision
Science, University of Sheffield, Sheffield, United
Kingdom;3Department of Ophthalmology, LudwigMaximilians-University, Munich, Germany;
4
Thrombogenics Inc, Leuven, Belgium; 5Xintera
Ltd, London, United Kingdom *CR
4057 — C0102 Epiretinal membrane formation
following treatment of retinal breaks. Abdallah
Jeroudi, K. J. Blinder. Vitreoretinal Surgery and
Diseases, The Retina Institute, St. Louis, MO
4058 — C0103 Internal Limiting Membrane
Peeling With Chromovitrectomy Induces Retinal
Glial Activation. Ahmet Hondur2, 1, Q. Zeng2, T.
H. Tezel2. 1Department of Ophthalmology, Gazi
University, Ankara, Turkey; 2Ophthalmology,
Columbia University College of Physicians and
Surgeons, The Edward Harkness Eye Institute,
New York, NY
4060 — C0105 Retinal displacement and
predictive factors for idiopathic macular hole
surgery. Qinghuai Liu, Z. Hu, P. Xie, S. Yuan.
Ophthalmology, Nanjing Medical University,
Nanjing, China
4061 — C0106 The different type of
contraction of epiretinal membrane in lamellar
macular hole. Alessandra Acquistapace, M. G.
Cereda, M. V. Cigada, F. Bottoni, G. Staurenghi.
Biomedical and Clinical Sciences “Luigi Sacco”,
Sacco Hospital Eye Clinic, University of Milan,
Milan, Italy *CR
4062 — C0107 Optic pit maculopathy Morphological criteria in SD-OCT examination.
Klaus Wehrmann, N. Feucht, C. P. lohmann, M.
M. Maier. Department of Ophthalmology, TU
München, Muenchen, Germany
4064 — C0109 Spanish Retina Society- VMT
study: Prevalence Of Vitreomacular Adhesions
And Tractions In A Healthy Population Over 45
Years Of Age. Miguel A. Zapata1, M. S. Figueroa2.
1
Retina, Hospital Vall Hebron, Barcelona, Spain;
2
Retina, Hospital Universitario Ramon y Cajal,
Madrid, Spain
4065 — C0110 Analysis of the ganglion cell
layer-inner plexiform layer thickness after
internal limiting membrane peeling in epiretinal
membrane, macular hole patients. Jung Min
Park1, J. Lee1, S. Lee2.1ophthalmology, Maryknoll
medical center, Busan, Korea (the Republic of);
2
Haeundae Paik Hospital, Busan, Korea
(the Republic of)
4066 — C0111 Effect of changes in central
macular thickness (CMT) and shape on visual
acuity after idiopathic epiretinal membrane
(ERM) removal. Sung Il Kang. Ophthamology,
Kyemyung Univ. Dongsan Medical Center, Daegu,
Korea (the Republic of)
4067 — C0112 Functional and morphological
assessment of patients with idiopatic epiretinal
membrane after surgical treatment. Giancarlo
Dell’Aversana Orabona, B. Gallo, A. Orrico,
P. Melillo, S. Rossi, F. Testa, M. Della Corte, F.
Simonelli. Multidisciplinary department of medicalsurgical and dental specialities, Second University
of Naples, Naples, Italy
4068 — C0113 En-face Imaging of epiretinal
membrane using swept source optical coherence
tomography. Jee Taek Kim. Ophthalmology,
Chung Ang University Hospital, Seoul, Korea (the
Republic of)
4069 — C0114 Idiopathic macular hole
in the fellow eye: prognostic significance of
vitreomacular traction at the first examination.
Polina Astroz Evtouchenko, E. Philippakis, R.
Tadayoni, A. Gaudric. Ophtalmology, Lariboisière
Hospital, Paris, France
4070 — C0115 Do peripheral retinal lesions
impact the vitreo interface in the posterior
pole? Nicola Quinn1, K. Graham1, D. Elliot1,
R. Hennessy1, D. Wright2, A. Muldrew1, U.
Chakravarthy1, T. Peto3, 4, R. E. Hogg1. 1Centre for
Experimental Medicine, Queen’s University Belfast,
Fintona, United Kingdom; 2Centre for Public
Health, Queen’s University Belfast, Belfast, United
Kingdom; 3NIHR Biomedical Research Centre,
Moorfield’s Eye Hospital NHS Foundation Trust,
London, United Kingdom; 4UCL of Opthalmology
London, London, United Kingdom *CR
4071 — C0116 Prevalence of macular
abnormalities assessed by Optical Coherence
Tomography in patients with Usher Syndrome.
Beatrice Gallo1, R. Colucci1, A. De Benedictis1, R.
Brunetti-Pierri1, P. Melillo1, S. Rossi1, F. Testa1,
C. Azzolini2, M. Della Corte1, F. Simonelli1. 1Eye
Clinic, Multidisciplinary Department of Medical,
Surgical and Dental Sciences, Second University of
Naples, Naples, Italy; 2Section of Ophthalmology,
Department of Surgical and Morphological
Sciences, University of Insubria, Varese, Italy
4072 — C0117 Long term follow-up of fellow
eye in patients with lamellar macular hole. Ugo
Nava, I. D’Agostino, C. Preziosa, M. G. Cereda,
F. Bottoni, G. Staurenghi. Biomedical and Clinical
Sciences “Luigi Sacco”, Sacco Hospital Eye Clinic
University of Milan, Milan, Italy *CR
4073 — C0118 Early spectral domain
optical coherence tomography findings after
spontaneous vitreomacular traction release.
David Ehmann, A. Shahlaee, E. Rahimy, J. Hsu.
Wills Eye Hospital, Philadelphia, PA
4074 — C0119 Real-life experience after
intravitreal ocriplasmin for vitreomacular
traction and macular hole. Irini Chatziralli1,
G. Theodossiadis2, E. Parikakis3, I. Datseris4,
P. Theodossiadis1. 12nd Department of
Ophthalmology, University of Athens, Athens,
Greece; 22nd Department of Ophthalmology, Henry
Dunant Hospital, Athens, Greece; 3Ophthalmiatrion
Athinon, Athens, Greece; 4OMMA Eye Institute,
Athens, Greece
4075 — C0120 Characteristics of the
vitreomacular interface diseases assessed
by optical coherence tomography. Antonio
Ferreras1, 2, P. Ramiro3, P. Calvo1, 2, A. B. Pajarin4,
B. Abadia1. 1Ophthalmology, Miguel Servet
University Hospital. IIS Aragon, Zaragoza,
Spain; 2Ophthalmology, University of Zaragoza,
Zaragoza, Spain; 3Hospital Clínico Universitario
Lozano Blesa, Zaragoza, Spain; 4Centro de Salud
Seminario, Zaragoza, Spain*CR
4076 — C0121 Lamellar macular hole
associated with epiretinal membrane. Clinical
and morphological aspects. Elena Zampedri, R.
Frisina, F. romanelli. APSS Trento, Multizonal Unit
of Ophthalmology, Rovereto, Italy
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
275
Tuesday Posters
3:45 pm – 5:30 pm
4059 — C0104 The effect of spontaneous vs.
surgical posterior vitreous detachment (PVD)
on epiretinal membrane (ERM) formation in
patients undergoing pars plana vitrectomy
(PPV) for symptomatic vitreous opacities. Olga
Shif1, P. H. Scharper1, M. Ahmed2. 1Ophthalmology,
Krieger Eye Institute at Sinai Hospital of Baltimore,
Baltimore, MD; 2Ophthalmology, Wilmer Eye
Institute at Johns Hopkins, Baltimore, MD
4063 — C0108 ORBIT: A phase IV clinical
study - lessons learned from patient selection
criteria for ocriplasmin intravitreal injection.
Brian C. Joondeph2, 1, J. S. Duker3, 4, D. S. Boyer5, 6,
J. S. Heier7, P. K. Kaiser8, M. W. MacCumber9, 10,
D. J. Pieramici11, 12. 1Rocky Vista University School
of Osteopathic Medicine, Parker, CO; 2Colorado
Retina Associates, Denver, CO; 3New England Eye
Center, Boston, MA; 4Tufts University School of
Medicine, Boston, MA; 5Retina-Vitreous Associates
Medical Group, Los Angeles, CA; 6University of
Southern California/Keck School of Medicine,
Los Angeles, CA; 7Ophthalmic Consultants of
Boston, Boston, MA; 8Cole Eye Institute, Cleveland
Clinic, Cleveland, OH; 9Illinois Retina Associates,
Chicago, IL; 10Rush University Medical Center,
Chicago, IL; 11California Retina Consultants,
Santa Barbara, CA; 12California Retina Research
Foundation, Santa Barbara, CA *CR, f
4077 – 4095 – Tuesday – Posters
4077 — C0122 Noval treatment for newly
symptomatic subretinal fluid in X-Linked
(Juvenile) Retinoschisis. Gibran S. Khurshid1,
S. Mukhtar2, P. Gupta3. 1National Eye Institute,
University of Florida, Gainesville, FL; 2VCU
School of Medicine, Richmond, VA; 3John hopkins,
Baltimore, MD
4078 — C0123 Topography of the Vitreoretinal
Interface in Vitreomacular Traction Syndrome.
Scott Walter1, D. S. Grewal1, D. Cunefare2,
P. K. Bhullar1, S. Farsiu2, T. H. Mahmoud1.
1
Ophthalmology, Duke University Eye Center,
Durham, NC; 2Biomedical Engineering, Duke
University, Durham, NC *CR
Tuesday Posters
3:45 pm – 5:30 pm
4079 — C0124 An assessment of vitreous
degeneration in eyes with macular holes and
vitreomacular traction. Quraish Ghadiali1, 2,
S. Zahid3, M. Engelbert1, 2. 1Ophthalmology,
Manhattan Eye Ear & Throat Hospital, New York,
NY; 2Vitreous Retina Macula Consultants of
New York, New York, NY; 3Ophthalmology,
New York University, New York, NY
4080 — C0125 The association between the
presence of epiretinal membrane and nerve fiber
layer defect in an adult Japanese population:
The Chikusei Eye Study. Atsuro Uchida1, M.
Sasaki1, 2, Y. Ozawa1, K. Motomura1, K. Yuki1, K.
Yamagishi3, N. Sawada4, S. Tsugane4, H. Iso5, K.
Tsubota1. 1Ophthalmology, Keio University School
of Medicine, Tokyo, Japan; 2Ophthalmology,
Tokyo Medical Center, Tokyo, Japan;3Public
Health Medicine, University of Tsukuba, Tsukuba,
Japan; 4Research Center for Cancer Prevention and
Screening, National Cancer Center, Tokyo, Japan;
5
Public Health, Social and Environmental Health,
Osaka University Graduate School of Medicine,
Osaka, Japan
4081 — C0126 Tangential Contraction and
Early Vision Loss in Idiopathic Epiretinal
Membrane Patients. Ik Soo Byon. Pusan National
University Yangsan Hospital, Yangsan, Korea
(the Republic of)
4082 — C0127 The Evolution of Pre-Existing
Epiretinal Membranes Following Cataract
Extraction. Kevin Wells, L. Lindsell, G. Reilly.
Ophthalmology, Georgetown University Hospital,
Washington, DC
4083 — C0128 Correlation Between Degree
of Metamorphopsia and Optical Coherence
Tomography Findings in Epiretinal Membrane.
Sung Yong Park, M. Jung, P. Kim, C. Moon.
Ophthalomology, Soonchunhyang Univ. Cheonan
Hospital, Cheonan-si, Korea (the Republic of)
4084 — C0129 Internal Limiting Membrane
Folding in Epiretinal Membrane: Prevalence,
Morphologic Characteristics, and Clinical
Implications. Seung Hun Park, S. Ahn, E. Hong, B.
Lee. Ophthalmology, Hanyang University Hospital,
Seoul, Korea (the Republic of)
4085 — C0130 Vitreoretinal interface
abnormalities in older patients with history of
retinopathy of prematurity. Aristomenis Thanos1,
Y. Yonekawa1, B. Todorich1, B. Thomas1, N. T.
Huang2, K. A. Drenser1, M. T. Trese1, A. Capone1.
1
Retina, Associated Retinal Consultants, Royal
Oak, MI; 2Medicine, Oakland University William
Beaumont School of Medicine, Rochester, MI
4086 — C0131 Vitreous Proteins Implicated
in Idiopathic Macular Hole Formation. Sharon
D. Solomon1, R. Semba1, P. Zhang1, R. Turner3, J.
Qian1, Y. Zhao1, P. A. Campochiaro1, I. E. ZimmerGaller1, I. Han1, Y. M. Paulus2, S. A. Shah1. 1Wilmer
Eye Institute Johns Hopkins, Baltimore, MD;
2
Kellogg Eye Center, Ann Arbor, MI; 3University of
Maryland, Baltimore, MD
4087 — C0132 Association of Epiretinal
Membrane with Development of Lamellar Hole.
Seong Joon Ahn, J. Kim, S. Park, B. Lee. Hanyang
University, Seoul, Korea (the Republic of)
Exhibit/Poster Hall C0162-C0194
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Anatomy and Pathology/Oncology
381 Melanoma and Lymphoma: from
Models to Man
Moderators: Jonathan H. Lin, Gülçin Gezgin and
Zelia M. Correa
4088 — C0162 Epidemiological Trends in 1,739
Cases of Orbital Lymphoma in the United States.
Siya Huo, M. Andreoli, V. K. Aakalu, P. Setabutr.
Ophthalmology, Illinois Eye and Ear Infirmary,
Chicago, IL
4089 — C0163 Comprehensive Genomic
Profiling of Orbital and Ocular Adnexal
Lymphomas Identifies Frequent Alterations in
MYD88 and Chromatin Modifiers: New Routes
to Targeted Therapies.Rajesh C. Rao1, 2, A.
Cani1, M. Soliman1, D. H. Hovelson1, C. Liu1, A. S.
McDaniel1, M. J. Haller1, J. Bratley1, S. Rahrig1, C.
A. Briceno1, S. A. Tomlins1. 1University of Michigan,
Ann Arbor, MI; 2Ophthalmology, VA Ann Arbor
Healthsystem, Ann Arbor, MI *CR
4090 — C0164 Diagnostic significance of
the vitreous fluid of patients with intraocular
B-cell lymphoma. Kenji Nagata1, T. Inaba2,
K. Kitazawa3, 1, Y. Sekiyama1, S. Kinoshita3, C.
Sotozono1.1Ophthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan; 2Infection
Control and Laboratory Medicine, Kyoto
Prefectural University of Medicine, Kyoto, Japan;
3
frontier medical science and technology for
ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan
4091 — C0165 Enhancement of radiation
effects on lymphoma cells using gold
nanoparticles: an in vitro study and Monte
Carlo simulation. Fatemeh Alikarami1, 2, S.
Asadi3, S. Balagholi2, 4, M. Rezaeikanavi2, M. Safa1.
1
Department of Hematology, School of Allied
Medicine, Iran University of Medical Sciences,
Tehran, Iran (the Islamic Republic of); 2Ocular
Tissue Engineering Research Center, Shahid
Beheshti University of Medical Sciences, Tehran,
Iran (the Islamic Republic of); 3Department of
Physics, K. N. Toosi University of Technology,
Tehran, Iran (the Islamic Republic of); 4Department
of Hematology, Faculty of Allied Medicine, Tehran
University of Medical Sciences, Tehran, Iran (the
Islamic Republic of)
4092 — C0166 Clinical features of Systemic
metastatic retinal lymphoma in Japanese
patients. Rumiko Taki1, A. Takeda1, H. Yoshikawa1,
T. Fukuhara1, R. Arita1, Y. Suehiro2, I. Choi2, T.
Ishibashi1, K. Sonoda1. 1Ophthalmology, Kyushu
University, Fukuoka, Japan; 2Haematology, National
Hospital Organization Kyusyu Cancer Center,
Fukuoka, Japan f
4093 — C0167 Combined intravitreal
methotrexate and immunochemotherapy
followed by reduced-dose whole-brain
radiotherapy for newly diagnosed primary
B-cell intraocular lymphoma. Junko Matsuda1, 2,
T. Kaburaki2, R. Tanaka2, M. Takamoto2, H.
Nakahara2, K. Ohtomo2, Y. Fujino2, J. Numaga1,
H. Yamashita4, M. Kurokawa3, M. Aihara2.
1
Ophthalmology, The Tokyo Metropolitan Geriatric
Hospital, Tokyo, Japan; 2Ophthalmology, The
University of Tokyo Hospital, Tokyo, Japan;
3
Hematology, The University of Tokyo Hospital,
Tokyo, Japan; 4Radiology, The University of Tokyo
Hospital, Tokyo, Japan f
4094 — C0168 Repeat Episcleral Plaque
Brachytherapy: Clinical Outcomes in Patients
Treated for Locally Recurrent Choroidal
Melanoma (CM). Benjamin King1, H. Wynn1, B.
Gao1, V. M. Morales3, M. T. Ballo2, M. W. Wilson1.
1
Department of Ophthalmology, University of
Tennessee Health Sciences Center, Memphis, TN;
2
Department of Radiation Oncology, University
of Tennessee Health Sciences Center, Memphis,
TN;3Department of Microbiology, Immunology
and Biochemistry, University of Tennessee Health
Sciences Center, Memphis, TN
4095 — C0169 A new method to determine
correct Ruthenium-106 brachytherapy dose to
ocular tumor apex using ultrasonography B-scan
artifacts. Jens F. Kiilgaard1, C. Espensen1, 2, P. K.
Jensen3, L. S. Fog2, K. Klemp1, H. C. Fledelius1,
L. Specht2. 1Ophthalmology, Rigshospitalet,
Copenhagen, Denmark; 2Oncology, Rigshospitaet,
Copenhagen, Denmark; 3Ophthalmology, Roskilde
Hospital, Roskilde, Denmark
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
276
Tuesday – Posters – 4096 – 4119
4096 — C0170 Genetic Risk Factors for
Radiation Vasculopathy. Thanos D. Papakostas1,
A. Lane1, C. Awh1, M. Morrison1, M. M. DeAngelis2,
E. S. Gragoudas1, I. K. Kim1. 1Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA;
2
Moran Eye Center, Salt Lake City, UT
4097 — C0171 Radiation retinopathy after
proton beam therapy in uveal melanoma.
Ira Seibel, A. I. Riechardt, A. Davids, A. Böker,
M. Rehak, A. Hager, A. M. Joussen. Charité
Universitätsmedizin Berlin, Berlin, Germany
4098 — C0172 Intravitreal Dexamethasone
for Recalcitrant CME following Brachytherapy
Treatment of Uveal Melanoma. William F. Mieler.
Illinois Eye & Ear Infirmary, Chicago, IL
4099 — C0173 High dose (2.5 mg) intravitreal
bevacizumab as rescue therapy for persistent
post-radiation cystoid macular edema. M. Ali
Khan, A. Mashayekhi, K. Ferguson, J. A. Shields,
C. L. Shields. Ophthalmology, Wills Eye Hospital,
Philadelphia, PA
4100 — C0174 Glaucoma after Iodine-125
Brachytherapy for Uveal Melanoma: Incidence
and Risk Factors. Eun-Ah Kim1, M. Kamrava2,
J. Lamb2, J. Caprioli1, T. A. McCannel1. 1Jules
Stein Eye Institute, Los Angeles, CA; 2Department
of Radiation Oncology David Geffen School of
Medicine, Los Angles, CA
4102 — C0176 A numerical model to calculate
the influence of the viscosity of the vitreous
humor during laser-induced thermal damage in
choroidal melanomas. Alcides Fernandes1, O. P.
Garcia2, P. R. Lyra2, R. C. Lima2. 1Ophthalmology,
Emory University, Atlanta, GA; 2Mechanical
Engineering, Federal University of Pernambuco,
Recife, Brazil
4103 — C0177 Establishment of Orthotopic
Lacrimal Gland B-cell Lymphoma Model in
Mice. Min Joung Lee1, S. Park2, S. Yoon2, J. Ko2,
H. Lee2, M. Kim2, 3, W. Wee2, 3, S. Khwarg3, J.
Oh2, 3. 1Ophthalmology, Hallym University Sacred
Heart Hospital, Anyang, Korea (the Republic of);
2
Laboratory of Ocular Regenerative Medicine
Immunology, Biomedical Research Institute, Seoul,
Korea (the Republic of);3Ophthalmology, Seoul
National University Hospital, Seoul, Korea
(the Republic of)
4104 — C0178 Zeaxanthin inhibits Growth
and Invasion of Human Uveal Melanoma in
Nude Mouse Model. Dan-Ning Hu1, X. L. Xu2, C.
E. Iacob1, A. Jordan1, S. Gandhi1, D. L. Gierhart3,
R. B. Rosen1.1New York Eye and Ear Infirmary
of Mount Sinai, New York, NY; 2Memorial
Sloan-Kettering Cancer Center, New York, NY;
3
ZeaVision LLC, Chesterfield, MT *CR
4106 — C0180 C-Kit Expression in an Animal
Model of Uveal Melanoma Mirrors That of
Humans. Taylor Nayman, D. Sanft, R. Amade,
S. Aldrees, E. Esposito, M. N. Burnier. Ocular
Pathology, McGill University, Montreal, QC,
Canada
4107 — C0181 Expression of Several
Melanoma Markers in a Uveal Melanoma
Animal Model. Luiza A. Minussi, C. A. Moreira, J.
P. Passos, S. Bakalian, F. Muccioli, M. N. Burnier.
McGill, Campinas, Brazil
4108 — C0182 Mouse eye as a model for
non-surical investigation of cancer nanotheranostics. Mayank Goswami2, 1, X. Wang1, P.
Zhang2, 1, W. Xiao3, Y. Li3, R. J. Zawadzki2, 4, K.
Lam3, E. N. Pugh2, 1.1Cell Biology and Human
Anatomy, UC Davis, Davis, CA; 2EyePod Mouse
Imaging Laboratory, UC Davis, Davis, Afghanistan;
3
Comprehensive Cancer Center, Department of
Biochemistry and Molecular Medicine, UC Davis,
Sacramento, CA; 4Ophthalmology & Vision
Science, UC Davis, Sacramento, CA *CR
4109 — C0183 Verteporfin inhibits growth
of human ocular glioma in vitro without light
activation. Ahmad Al Moujahed1, K. Brodowska1,
T. Stryjewski1, J. Cichy2, E. S. Gragoudas1, D.
G. Vavvas1.1Ophthalmology, Massachusetts Eye
and Ear Infirmary, Harvard Medical School,
Boston, MA; 2Dept. of Immunology, Faculty of
Biochemistry, Biophysics and Biotechnology,
Jagiellonian University, Krakow, Poland *CR
4110 — C0184 The differences in expression
of HMB 45, Melan A and COX 2 in canine and
human uveal melanoma. Evangelina Esposito,
P. M. Barros, E. Perlmann, E. Mayo-Goldberg, A.
T. Dias, M. N. Burnier. Henry C. Witelson Ocular
Pathology Laboratory, McGill University, Montreal,
QC, Canada
4111 — C0185 Assessment of the activity of
different AU-011 doses in a xenograft uveal
melanoma model. Patrick T. Logan, P. Zoroquiain,
S. Aldrees, M. F. Qutub, N. Vila, M. N. Burnier.
Pathology, McGill University, Montreal, QC,
Canada *CR
4112 — C0186 Expression of SIRT1 in a Uveal
Melanoma Animal Model. Debra-Meghan Sanft1,
C. Mastromonaco2, A. T. Dias2, M. Burnier3, S. C.
Maloney2, M. N. Burnier2. 1Ophthalmology, McGill
University, Montreal, QC, Canada; 2Henry C
Whitelson Ocular Pathology Laboratory, Montreal,
QC, Canada; 3Faculdade de Ciencias Medicas e
Saude de Juiz de Fora, Juiz de Fora, Brazil
4113 — C0187 Metastatic Ocular Melanoma
to the Liver Exhibits Infiltrative and Nodular
Growth Patterns in Mouse Models. Shuo You1,
Q. Zhang1, J. lattier2, H. Yang1, S. kang1, H. E.
Grossniklaus1.1Emory University, Atlanta, GA; 2MD
Anderson Cancer Institute, Houston, TX
4114 — C0188 Ocular metastasis in dogs:
a retrospective study of 320 cases. Leandro
B. Teixeira, R. R. Dubielzig. Experimental
Ophthalmology, UW-Madison Sch of Vet Med,
Madison, WI
4115 — C0189 GnRH Expression in Uveal
Melanoma as a potential therapeutic target.
Juliana Portela Passos, P. Zoroquiain, J. J.
Mansure, W. Almajed, O. Dias, M. N. Burnier.
Henry C. Witelson Ocular Pathology Laboratory,
McGill University, Ancaster, ON, Canada
4116 — C0190 ZEB1 targets multiple
malignancy-related components to promote
uveal melanoma cell dedifferentiation,
proliferation, invasion, and metastasis. Yao
Chen2, 1, X. Lu1, D. E. Durango1, D. S. Darling1,
L. Gao2, Y. Liu1, D. C. Dean1. 1Department of
Periodontics, Endodontics, and Dental Hygiene,
University of Louisville, Louisville, KY; 2The
Second Xiangya Hospital, Central South University,
Changsha, China
4117 — C0191 The effect of oncometabolite
2-hydroxyglutarate on the biological behavior of
differentiated melanocytes and uveal melanoma
cells. Cindy Weidmann1, C. Quirke1, C. Yao1, C. M.
Lowry3, J. Pomerleau1, J. Wagner3, S. Landreville1, 2.
1
Axe médecine régénératrice et Centre universitaire
d’ophtalmologie-Recherche, Centre de Recherche
du CHU de Québec, Quebec City, QC, Canada;
2
Département d’ophtalmologie, Université Laval,
Quebec City, QC, Canada; 3Département de
médecine nucléaire et de radiobiologie, Université
de Sherbrooke, Sherbrooke, QC, Canada
4118 — C0192 Pharmacological Inhibition
of Paxillin Reduces Cell Proliferation in
Uveal Melanoma Cell Lines. Bradley Gao1, L.
Djenderedjian1, W. Coppess1, Z. Goldsmith1, M.
W. Wilson1, 2, V. M. Morales1, 3. 1Ophthalmology,
University of Tennessee Health Science Center,
Memphis, TN; 2Surgery, St. Jude Children’s
Research Hospital, Memphis, TN; 3Microbiology,
Immunology and Biochemistry, University of
Tennessee Health Science Center, Memphis, TN
4119 — C0193 The Effect of varying intensities
of Blue Light on The Proliferation of Human
Uveal Melanoma Cell-lines. Sultan Aldrees1, 2,
P. Zoroquiain1, P. Logan1, V. Bravo-Filho1, J.
Coblentz1, M. N. Burnier1. 1Pathology, McGill
University, Montreal, QC, Canada; 2Ophthalmology,
King Saud University, Riyadh, Saudi Arabia *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
277
Tuesday Posters
3:45 pm – 5:30 pm
4101 — C0175 Extrascleral tumor extension
associated with localized scleral melt following
plaque brachytherapy for uveal melanoma:
histopathologic findings. Chau Pham, S. Couch, G.
J. Harocopos. Ophthalmology and Visual Sciences,
Washington University in St Louis, St Louis, MO
4105 — C0179 Loss of BAP1 results in high
metastatic rate in a mouse ocular melanoma
model. Hua Yang1, Z. Li1, Q. Zhang1, C. M.
Craven1, S. E. Woodman2, T. A. McCannel3, H. E.
Grossniklaus1.1Ophthalmology, Emory University,
Atlanta, GA; 2Department of Melanoma Medical
Oncology and Systems Biology, University of
Texas, MD Anderson Cancer Center, Houston, TX;
3
Ophthalmology, UCLA, Los Angeles, CA
4120 – 4140 – Tuesday – Posters
4120 — C0194 Paxillin regulates UM cell
survival by PKC-delta signaling. Vanessa M.
Morales1, 2, S. R. Chintalapudi1, Z. Goldsmith1,
B. Gao1, P. Mendoza3, H. E. Grossniklaus3, M.
W. Wilson1, 4.1Ophthalmology, University of
Tennessee Health Science Center, Memphis, TN;
2
Microbiology, Immunology and Biochemistry,
University of Tennessee Health Science Center,
Memphis, TN; 3Ophthalmology, Emory University,
Atlanta, GA; 4Surgery, St. Jude Children’s Research
Hospital, Memphis, TN
Exhibit/Poster Hall D0001-D0028
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Immunology/Microbiology /
Clinical/Epidemiologic Research
382 Uveitis Epidemiology
Moderators: Ludwig M. Heindl and Steven Yeh
Tuesday Posters
3:45 pm – 5:30 pm
4121 — D0001 Thickening of retinal layers in
anterior uveitis in the absence of macular edema
and epiretinal membranes. Rafael S. Grajewski,
K. Burian, C. Cursiefen, L. M. Heindl. Department
of Opthalmology, University Eye Clinic Cologne,
Cologne, Germany
4122 — D0002 Baseline prognostic factors in
patients with Birdshot retinochoriopathy( BRC).
Chrysoula Koutsiouki1, A. G. Robson1, 2, G. E.
Holder1, 2, A. Rees1, C. Pavesio1, M. C. Westcott1, 3.
1
Medical Retina, Moorfields Eye Hospital, London,
United Kingdom; 2Electrodiagnostic, UCL Institute
of Ophthalmology, London, United Kingdom;
3
Medical Retina, Institute of ophthalmology,
London, United Kingdom *CR
4123 — D0003 One year prediction of low
vision in uveitis patients. Mia K. Grand1, 2,
H. Putter2, T. Missotten3, K. A. Vermeer1.
1
Rotterdam Ophthalmic Institute, Rotterdam,
Netherlands; 2Department of Medical statistics and
Bioinformatics, Leiden University Medical Center,
Leiden, Netherlands; 3Rotterdam Eye Hospital,
Rotterdam, Netherlands
4124 — D0004 Susac’s syndrome: Clinical
characteristics, clinical classification and long
term prognosis. Ofira Zloto1, J. Chapman2, R.
Sheinfeld2, T. Sharon1, R. Huna- Baron1, R. manor3,
Y. Shoenfeld4, V. Vishnevskia Dai1. 1Department of
Ophthalmology, Goldschleger Eye Institute, Sheba
Medical Center, Tel Hashomer, Israel; 2Department
of Neurology and the Sagol Neuroscience Center,
Sheba Medical Center, Tel Hashomer, Israel;
3
Department of Ophthalmology, Rabin Medical
center, Petah Tiqva, Israel; 4Zabludowicz Center for
Autoimmune Diseases, Sheba Medical Center, Tel
Hashomer, Israel
4125 — D0005 Uveitic Glaucoma: Longterm Clinical Outcome and Risk Factors for
Progression. Yael Sharon1, R. Friling1, 2, M.
Lusky1, B. Quizhpe Campoverde3, A. Radgonde3,
M. Kramer1.1Ophthalmology, Rabin Medical
Center - Beilinson Hospital, Petach-Tikva,
Israel; 2Ophthalmology, Schneider Children’s
Medical Center of Israel, Petach-Tikva, Israel;
3
Ophthalmology, Hadassah University Hospital,
Jerusalem, Israel
4126 — D0006 The Impact Of Applying The
Proposed New 2014 International Criteria
For Behçet’s Disease: The Birmingham UK
Experience. Philip I. Murray1, 2, T. Blake2, D.
Carruthers2, E. Damato2, A. K. Denniston1, 2, J.
Hamburger1, 2, A. Richards2, A. Poveda-Gallego2,
V. Sewell2, D. Mitton2, D. Situnayake2. 1College
of Medical and Dental Sciences, University of
Birmingham, Birmingham, United Kingdom;
2
Sandwell and West Birmingham Hospitals NHS
Trust, Birmingham, United Kingdom
4127 — D0007 Clinical Characteristics of
Multiple Sclerosis Associated Uveitis in the
Southeastern United States. Russell W. Read.
Ophthalmology, University of Alabama at
Birmingham, Birmingham, AL *CR
4132 — D0012 Analysis and outcome of 80
cases of herpetic anterior uveitis at a tertiary
referral eye care centre in Singapore. Rosalynn
Siantar1, R. Lim1, E. Wong1, S. Ho1, S. Teoh2, R. V.
Agrawal1.1Ophthalmology, National Healthcare
Group Eye Institute, Tan Tock Seng Hospital,
Singapore, Singapore, Singapore; 2Eagle Eye
Centre, Singapore, Singapore
4133 — D0013 Juvenile idiopathic arthritis
- associated uveitis: occurrence and course
of ocular hypotony. Arnd Heiligenhaus1, 2, M.
Böhm1, 4, C. Tappeiner1, 3, M. Breitbach1, B. ZurekImhoff1, C. Heinz1, 2.1Department of Ophthalmology
at St. Franziskus Hospital Münster, Muenster,
Germany; 2University of Duisburg-Essen, Essen,
Germany; 3Department of Ophthalmology,
Inselspital, University, Bern, Switzerland;
4
Department of Ophthalmology, University Clinic,
Essen, Germany
4134 — D0014 The demographics and
comorbid conditions of patients diagnosed
with intermediate uveitis. May Shum, E. Crane,
J. S. Kim, E. Kim, D. S. Chu. Institution of
Ophthalmology and Visual Sciences, Rutgers New
Jersey Medical School, Newark, NJ
4128 — D0008 Malpractice Litigation in
Uveitis and Ocular Inflammation. Ashvini
Reddy1, S. B. Engelhard2, C. Shah2, A. Sim2.
1
Ophthalmology, Wilmer Eye Institute, Johns
Hopkins, Baltimore, MD;2Ophthlamology,
University of Virginia, Charlottesville, VA
4135 — D0015 Syphilitic Uveitis in Orange
County, California, 2015: A Case Series. Doran
Spencer1, C. Ried4, A. Pirouz2, A. Lam3, S. Lu1, M.
Mehta1. 1Ophthalmology, UC Irvine, Orange, CA;
2
Retinal Consultants of Orange County, Fullerton,
CA; 3St Jude Medical Center, Fullerton, CA;
4
Orange County Health Care Agency, Santa Ana, CA
4129 — D0009 Clinical characteristics of
Japanese patients with scleritis. Rie Tanaka, K.
Ohtomo, M. Takamoto, K. Komae, J. Numaga, Y.
Fujino, M. Aihara, T. Kaburaki. Ophthalmology,
The University of Tokyo Hospital, Bunkyo-ku, Japan
4136 — D0016 Chronic manifestations of
Vogt-Koyanagi-Harada disease. On-Tat Lee, H.
A. Aziz, J. Tan, J. L. Berry, D. C. Rodger, N. A. Rao.
Ophthalmology, USC Eye Institute, Los Angeles,
CA
4130 — D0010 JIA & Uveitis: The Patients’
Perspective. Brian Do1, 2, N. V. Nayak1, S. Kedhar1,
C. Samson1. 1Ophthalmology, The New York
Eye & Ear Infirmary of Mount Sinai, New York,
NY;2Ophthalmology, The Icahn School of Medicine
at Mount Sinai, New York, NY
4137 — D0017 Association of Vitamin D Levels
with Non-infectious Uveitis. Lindsay Grotting,
S. Davoudi, G. Papaliodis, L. Sobrin. Harvard
Department of Ophthalmology, Massachusetts Eye
and Ear, Boston, MA
4131 — D0011 Longitudinal vision related
quality of life in patients with non-infectious
uveitis. Elizabeth A. Sugar1, V. Venugopal5, J.
E. Thorne4, K. D. Frick2, G. N. Holland3, R. C.
Wang6, A. Robert3, J. T. Holbrook5. 1Department
of Biostatistics, Bloomberg Sch Public Hlth-JHU,
Baltimore, MD; 2Cary Business School, Johns
Hopkins University, Baltimore, MD; 3Jules Stein
Eye Institute, UCLA, Los Angeles, CA; 4Wilmer
Eye Institute, Johns Hopkins University, Baltimore,
MD; 5Epidemiology, Johns Hopkins University,
Baltimore, MD; 6Texas Retina Associates,
Dallas, TX *CR, f
4138 — D0018 Multimodal Imaging Of
Kyrieleis Plaques. Paola Carrai2, F. Pichi3, 1, A.
Invernizzi4, A. Mantovani6, F. Ricci5, G. Staurenghi4,
S. K. Srivastava3. 1San Giuseppe Hospital, Milan,
Italy; 2University of Milan, Milan, Italy; 3Cole
Eye Institute, Cleveland Clinic, Cleveland, OH;
4
Ospedale Sacco, Milan, Italy; 5Tor Vergata, Roma,
Italy; 6Ospedale Valduce, Como, Italy
4139 — D0019 The Bronx Epidemiology of
Uveitis Study (BEUS): A Clinic-based CaseControl Study of Uveitis and Potential Associated
Risk Factors. Stephen Walters, J. Powell, J.
Koelhoffer, D. C. Gritz. Ophthalmology, Montefiore
Medical Center, New York, NY
4140 — D0020 Ocular manifestations in
patients diagnosed with granulomatosis with
polyangiitis. Ana K. Escalona Brito, M. PedrozaSeres, R. Bobadilla. Ophthalmology, Instituto De
Oftalmologia Conde De Valenciana, DF, Mexico
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
278
Tuesday – Posters – 4141 – 4159
4141 — D0021 What about the ocular
inflammation in the elderly? Alejandro J.
Zermeno-Arce1, R. Bobadilla2, M. Pedroza-Seres2,
R. Moreno-Mendoza1. 1General Ophthalmology,
Instituto de Oftalmología Conde de Valenciana,
Mexico City, Mexico; 2Uveitis and Ocular
Inflammation, Instituto de Oftalmología Conde de
Valenciana, Mexico City, Mexico
4142 — D0022 Traumatic Uveitis Following
Blunt Ocular Trauma and Complications.
Ricardo Moreno-Mendoza1, M. Pedroza-Seres2,
R. Bobadilla2, M. Almanza1, A. J. Zermeno-Arce1.
1
General Ophthalmology, Instituto de Oftalmología
Conde de Valenciana, Mexico City, Mexico;
2
Uveitis and Ocular Inflammation, Instituto de
Oftalmología Conde de Valenciana, Mexico City,
Mexico
4143 — D0023 Characteristics of Multiple
Sclerosis Associated Uveitis. Himanshu Banda, C.
Stelton, S. Yeh. Ophthalmology, Emory University,
Atlanta, GA *CR
4144 — D0024 Birdshot’s chorioretinopathy: a
proposed morphological classification. Florence
Hoogewoud2, 1, S. Salah2, M. Guillard2, C. Bonnet2,
A. P. Brezin2, D. Monnet2. 1Geneva University
Hospital, Geneva, Switzerland; 2Cochin University
Hospital, Paris, France
4146 — D0026 Vogt Koyanagi Harada
Syndrome a review of 114 patients in Mexican
population. Rosalva Bobadilla, M. Pedroza-Seres.
Hospital Conde de Valenciana, Coacalco, Mexico
4147 — D0027 Novel Risk Factors for Ocular
Manifestations of Sarcoidosis in an Urban
Population. Devi Mehrotra, E. J. Schwaber, J.
Powell, T. Aldrich, D. C. Gritz. Montefiore Med
Ctr-Albert Einstein Coll of Med, Bronx, NY
4148 — D0028 Familial Cases of birdshot
Chorioretinopathy: genetic and epidemiology.
Clémence Bonnet, D. Monnet, A. P. Brezin.
Ophtalmologie, Hopital Cochin, Paris, France
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Retina
383 Macular Edema Clinical and
Translational
Moderator: Giuseppe Querques
4149 — D0063 Repeated Dexamethasone
Implants in Patients with Refractory Macular
Edema Receiving Anti-VEGF Therapy. Betsy
Colon, M. Busquets, P. Matthew. Retina, Associates
in Ophthalmology, Pittsburgh, PA
4150 — D0064 Dexamethasone implant with
rescue ranibizumab for treating macular edema
secondary to retinal vein occlusion. Sundeep Kasi,
E. Rahimy, J. A. Haller, A. Shahlaee. Retina, Wills
Eye Hospital, Philadelphia, PA *CR, f
4151 — D0065 Twelve-Month Follow-Up Of
Dexamethasone Implants For Macular Edema
From Various Diseases In Vitrectomized And
Non-Vitrectomized Eyes: Results From The Pan
American Collaborative Retina Study Group.
Renata T. Kato1, E. A. Novais1, M. Maia1, P. A.
Mello Filho1, J. R. Dias1, M. Avila5, A. Maia1, J.
Arevalo4, L. Wu2, M. H. Berrocal3, M. Farah1.
1
Federal University of Sao Paulo, Sao Paulo, Brazil;
2
Asociados de Macula, Vitreo y Retina de Costa
Rica, San Jose, Costa Rica; 3University of Puerto
Rico, San Juan, PR; 4Wilmer Eye Institute, John
Hopkins University, MD; 5Federal University of
Goiás, Sao Paulo, Brazil *CR
4152 — D0066 A 12-Month, Open-Label,
Multicenter Study to Assess the Safety and
Efficacy of Ozurdex 0.7 mg for the Treatment of
Macula Edema Related to Branch Retinal Vein
Occlusion in Korea; the COBALT Study. Young
Hee Yoon1, J. Kim4, D. Chang2, S. Simonyi3, J. LEE1.
1
Ophthalmology, Asan Medical Center, University
of Ulsan, College of Medicine, Seoul, Korea (the
Democratic People’s Republic of);2Allergan, Seoul,
Korea (the Democratic People’s Republic of);
3
Medical Affairs, Allergan, Singapore, Singapore;
4
Ophthalmology, Kim’s Eye Hospital, Konyang
University College of Medicine, Seoul, Korea (the
Democratic People’s Republic of) *CR, f
4153 — D0067 Dexamethasone implant
(Ozurdex©) intraocular pressure outcomes
in the real-world. Javier Zarranz-Ventura1, 2,
A. Sala-Puigdollers1, D. Velazquez Villoria3, M.
Figueras-Roca1, S. Copete3, L. N. Distefano3,
A. Boixadera Espax3, J. Garcia-Arumi3, A.
Adan Civera1. 1Ophthalmology, Hospital Clinic
Barcelona, Barcelona, Spain; 2Medical Retina
Service, Moorfields Eye Hospital, London, United
Kingdom; 3Retina Service, Hospital Vall de Hebron,
Barcelona, Spain *CR
4154 — D0068 Staged Combination Therapy
using Ranibizumab and Ozurdex for Retinal
Vein Occlusion Macular Edema: The RandO
Protocol. Peter Cikatricis1, A. Sarmad1, B.
Mushtaq1, S. Elsherbiny1, R. Chavan1, E. Damato1,
A. Mitra1, Y. C. Yang1, 2, P. Lip1. 1Birmingham
Midland Eye Centre, Birmingham, United
Kingdom; 2Wolverhampton Eye Infirmary,
Wolverhampton, United Kingdom
4155 — D0069 Bevacizumab in the treatment
of macular edema complicating retinal vein
occlusions. Julio A. Urrets-Zavalia1, M. GonzalezCastellanos1, E. Esposito1, 2, N. Crim1, L. Correa1,
D. Martinez1, M. Barros-Centeno1, H. M. Serra3.
1
Ophthalmology, University Clinic Reina Fabiola,
Universidad Catolica de Cordoba, Cordoba,
Argentina; 2Henry C. Wittelson Eye Pathology
Laboratory, McGill University, Montreal, QC,
Canada; 3CIBICI-CONICET, Faculty of Chemical
Sciences, Universidad Nacional de Cordoba,
Cordoba, Argentina
4156 — D0070 Comparing bevacizumab,
ranibizumab, and aflibercept for early reduction
of macular edema in patients with retinal vein
occlusions (RVO). Michael E. Jansen1, L. Tyler1, D.
Kermany2, J. Waters1, M. Singer2. 1Ophthalmology,
University of Texas Health Science Center, San
Antonio, TX; 2Medical Center Ophthalmology
Associates, San Antonio, TX *CR
4157 — D0071 Clinical management of
macular edema secondary to retinal vein
occlusion by retina specialists in clinical practice
in Spain: OBSERVAR Study. Carmen Navarro
Darder1, M. Abraldes3, A. Pareja2, M. Roura1, B.
Romero1. 1Novartis Pharma, Barcelona, Spain;
2
Hospital Universitario de Canarias, Tenerife, Spain;
3
Complexo Hospitalario Universitario de Santiago
de Compostela, Santiago de Compostela, Spain *CR
4158 — D0072 Anti-VEGF treatment of
macular edema using a treat-and-extend regimen
in retinal vein occlusion in clinical practice.
Manar Addou Regnard, A. Glacet-Bernard, R.
Mascali, E. H. Souied. Ophthalmology, Hôpital
Intercommunal de Créteil, University Paris Est,
Créteil, France
4159 — D0073 Management of macular edema
secondary to RVO with visual impairment in
real-life practice in France: Findings from the
cross-sectional BOREAL RVO study. Audrey
Derveloy1, A. Glacet Bernard2, F. Fajnkuchen3,
C. P. Garcher4, J. Girmens5, L. Kodjikian9, C.
Delcourt7, P. Guillausseau8, P. Massin6. 1Novartis
Pharma SAS, Rueil-Malmaison, France; 2Centre
Hospitalier Intercommunal de Créteil, Créteil,
France; 3Ophtalmology, Hopital Avicenne, Bobigny,
France; 4Ophtalmology, CHU Dijon, Dijon,
France; 5Hopital des Quinze-Vingt, Paris, France;
6
Ophtalmology, Hopital Lariboisiére, Paris, France;
7
ISPEP, Bordeaux, France; 8Hopital Lariboisiére,
Paris, France; 9Ophtalmology, Hospice Civils de
Lyon, Lyon, France *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
279
Tuesday Posters
3:45 pm – 5:30 pm
4145 — D0025 Patterns of Ocular
Manifestations in Ebola Virus Disease Survivors
in the Port Loko, Sierra Leone. Matthew Vandy1,
J. Mattia1, J. Chang2, D. Platt2, Y. Mansaray3,
A. Kamara3, R. Pinto6, D. Bausch4, J. Shantha5,
S. Yeh5, K. Dierberg2. 1Lowell and Ruth Gess
Eye Hospital, Freetown, Sierra Leone; 2Partners
in Health, Boston, MA; 3Lunsar Baptist Eye
Hospital, Port Loko, Sierra Leone; 4World Health
Organization, Geneva, Switzerland; 5Emory Eye
Center, Atlanta, GA; 6University of Toronto,
Toronto, ON, Canada
Exhibit/Poster Hall D0063-D0098
4160 – 4182 – Tuesday – Posters
4160 — D0074 Real World Comparison Of
Ranbiziumab And Bevacizumab For Macular
Edema Secondary To Retinal Vein Occlusions.
Mehnaz Khan, K. M. Wai, F. Q. Silva, S. K.
Srivastava, J. P. Ehlers, A. Rachitskaya, R. Deasy,
A. Schachat, P. K. Kaiser, A. Yuan, R. P. Singh. Cole
Eye Institute, Cleveland Clinic, Cleveland, OH *CR
4168 — D0082 Correlation of diabetic macular
edema intraretinal cyst reflectivity on SD-OCT
to anti-VEGF treatment response. Nathan R.
Haines1, R. Sanders2, R. Y. Hwang1, J. Olson1.
1
Ophthalmology, University of Colorado Health Eye
Center, Denver, CO; 2Mercer University School of
Medicine, Macon, GA
4175 — D0089 Increased Frequency of Topical
Steroids Provides Benefit in Treatment of
Postsurgical Cystoid Macular Edema. Saleema
A. Kherani, Y. S. Han, G. Hafiz, C. Krispel, T. A.
Liu, T. A. Mir, P. A. Campochiaro. Ophthalmology,
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD *CR, f
4161 — D0075 Retina specialists treating
cystoid macular edema secondary to retinal vein
occlusion recommend different treatments for
patients than they would choose for themselves.
Marlene D. Wang1, S. P. Shah1, 2, K. W. Jeng1, H.
Feng1, H. F. Fine1, 2, J. L. Prenner1, 2. 1Rutgers
Robert Wood Johnson Medical School, New
Brunswick, NJ; 2NJ Retina, New Brunswick, NJ *CR
4169 — D0083 Optical coherence tomography
of macular edema in uveitis and retinal vein
occlusion: a comparative study. Pierre Sustronck,
N. Massamba, V. Touitou, P. Lehoang, B. Bodaghi.
Pitié-Salpetrière, Charenton le Pont, France
4176 — D0090 Dexamethasone intravitreal
implant for macular edema associated with
retinitis pigmentosa. Junghyun Park1, H. Yu2.
1
Ophthalmology, Seoul Paik Hospital, Inje
University, Seoul, Korea (the Republic of);
2
Ophthalmology, Seoul National University, Seoul,
Korea (the Republic of)
4162 — D0076 Real world clinical audit of
aflibercept for management of macular edema
secondary to central retinal vein occlusion.
Kaivon Pakzad-Vaezi1, M. El-Atfy2, E. Vrizidou1,
P. Addison1. 1Medical Retina, Moorfields Eye
Hospital, London, United Kingdom; 2University
College London, London, United Kingdom *CR
Tuesday Posters
3:45 pm – 5:30 pm
4163 — D0077 Individualized ranibizumab
dosing effective for maintaining visual acuity
gains in patients with BRVO and CRVO. Mimi
Liu1, P. Wang2, Z. Haskova2. 1Colorado Retina
Associates, Denver, CO; 2Genentech, Inc, South
San Francisco, CA *CR, f
4164 — D0078 Presence of subretinal fluid
at baseline preserves from photoreceptor
alterations in diabetic macular edema
and cystoid macular edema due to central
retinal vein occlusion. Ana-Maria Philip1, D.
Podkowinski1, E. Pablik2, A. Montuoro1, S. M.
Waldstein1, B. Gerendas1, U. Schmidt-Erfurth1.
1
Christian Doppler Laboratory for Ophthalmic
Image Analysis, Department of Ophthalmology,
Vienna Reading Center, Vienna, Austria, Vienna,
Austria; 2Center for Medical Statistics, Informatics,
and Intelligent Systems Medical University Vienna,
Vienna, Austria *CR, f
4165 — D0079 Correlation of Subfoveal
Choroidal Thickness with Change in Central
Foveal Thickness and BCVA in Hispanic and
Caribbean Patients Treated with Anti-VEGF
for Diabetic Macular Edema. Amy Mehta, B. B.
Johnson, P. Rosenbaum, J. Levine. Ophthalmology,
Bronx Lebanon Hospital Center, New York, NY
4166 — D0080 Predictive factors for visual
outcome and risk factors for persistent macular
edema in patients with branch retinal vein
occlusion. Taneto Tomiyasu, Y. Hirano, N. Suzuki,
M. Yoshida, A. Uemura, T. Yasukawa, Y. Ogura.
Department of Ophthalmology and Visual Science,
Nagoya City University Graduate School of
Medical Sciences, Nagoya, Japan
4167 — D0081 Predictive Value of
Peripapillary Retinal Nerve Fiber Layer
Thickness in Patients with Retinal Vein
Occlusion. Anton M. Kolomeyer, Y. Ling, E. Duerr,
G. Wollstein, J. N. Martel. UPMC, Pittsburgh, PA
4170 — D0084 Adaptive Optics Scanning
Laser Ophthalmoscopy (AOSLO) in Patients
with Central Retinal Vein Occlusion (CRVO)
and Cystoid Macular Edema (CME): A
SCORE2 Ancillary Study.Shane Griffin9, A.
Roorda1, M. M. Chung2, H. Song2, J. Carroll3, J.
I. Morgan4, T. Chui5, 6, R. B. Rosen5, B. A. Blodi7,
I. U. Scott8, J. L. Duncan9. 1School of Optometry
and Vision Science Graduate Group, University of
California at Berkeley, Berkeley, CA; 2Flaum Eye
Institute, Center for Visual Science, University
of Rochester, Rochester, NY; 3Department of
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 4Scheie Eye Institute, Department
of Ophthalmology, University of Pennsylvania,
Philadelphia, PA; 5Department of Ophthalmology,
New York Eye and Ear Infirmary of Mount Sinai,
New York, NY; 6Icahn School of Medicine at
Mount Sinai, New York, NY; 7Department of
Opthalmology and Visual Sciences, University of
Wisconsin Madison, Madison, WI; 8Hershey Eye
Center, Penn State, Hershey, PA; 9Department
of Ophthalmology, University of California San
Francisco, San Francisco, CA *CR, f
4171 — D0085 Baseline and sequential
predictors of chronic refractory macular edema
secondary to branch retinal vein occlusion
after anti-VEGF; a long-term follow-up study.
June-Gone Kim, B. Moon, J. LEE, Y. Yoon.
Ophthalmology, Asan Medical Center, Seoul, Korea
(the Republic of)
4172 — D0086 Two cases of unexpected
radiation retinopathy: one after 20 Gy orbital
and one after 30 Gy whole-brain radiation.
Katarina Hurtikova1, S. Tschuppert1, H. Gerding1, 2.
1
Departement of Ophthalmology, Pallas Klinik,
Olten, Switzerland; 2Department of Ophthalmology,
University of Münster, Münster, Germany
4173 — D0087 Reduction of macular edema
from radiation retinopathy using intravitreal
dexamethasone-implant (Ozurdex®). James
Snitzer, S. C. Oliver. Ophthalmology, University of
Colorado Denver, Denver, CO *CR
4174 — D0088 A Retrospective Observational
Study on the Prevalence of Pseudophakic
Cystoid Macular Oedema (CMO) in a Diabetic
Population. Elizabeth M. Walsh1, R. D. Hamilton2, 1,
C. Pavesio2, 1.1Medical Retinal, Moorfields Eye
Hospital, London, United Kingdom; 2NIHR BRC at
Moorfields Eye Hospital, London, United Kingdom
*CR
4177 — D0091 Drug-induced macular edema.
Victor Llorens, M. Mesquida, B. Molins, J. Matas,
A. Sala-Puigdollers, J. Zarranz-Ventura, M. Sainz
De La Maza, A. Adan Civera. Clínic Institute of
Ophthalmology, Hospital Clínic of Barcelona,
Barcelona, Spain
4178 — D0092 Relationship Between
Prostaglandin Analog Use and Cystoid Macular
Edema. Kam Vaziri1, S. Pershing2, K. S. Kishor1,
S. G. Schwartz1, 3, H. W. Flynn1, J. Fortun1, D. M.
Moshfeghi2, A. A. Moshfeghi4. 1Ophthalmology,
Bascom Palmer Eye Insititue, Palm Beach Gardens,
FL; 2Ophthalmology, Byers Eye Institute, Stanford
University School of Medicine, Palo Alto, CA;
3
Ophthalmology, Veterans Affairs Palo Alto Health
Care System, Palo Alto, CA; 4Ophthalmology, USC
Eye Institute, University of Southern California
Keck School of Medicine, Los Angeles, CA
4179 — D0093 Characterization of
DL-2-aminoadipic acid-induced retinal
neovascularization and leakage in nonhuman
primates. W. Hu, R. Brookes, A. Lewis, V. Woodley,
D. James, S. Henry, R. J. Goody, J. Attwood, M. S.
Lawrence, Wenzheng Hu. RxGen, Inc.,
Hamden, CT *CR
4180 — D0094 Aqueous Angiopoietin-like
4 Levels Correlate with Nonperfusion Area
and Macular Edema in Branch Retinal Vein
Occlusion. Dong Ho Park, J. Kim, J. Im, J. Shin,
I. Kim. Ophthalmology, Kyungpook National Univ
Hospital, Daegu, Korea (the Republic of)
4181 — D0095 Analysis of Aqueous Cytokines
According to Naïve Diabetic Macular Edema
Patterns as based on Optical Coherence
Tomography. Jin Young Kim1, W. Lee2, S. Park2.
1
Ophthalmology, Department of Ophthalmology,
Jeju National University Hospital, Jeju National
University School of Medicine, Jeju, Korea (the
Republic of); 2Ophthalmology, Department of
Ophthalmology, Kangdong Sacred Heart Hospital,
Hallym University College of Medicine, Seoul,
Korea (the Republic of)
4182 — D0096 Aqueous humour
Biomarkers:Bespoke Therapeutical
approach to Macular edema in Retinal Vein
Occlusions(ABVO study). Neha Sudhakar Peraka.
Retina Ophthalmology, Narayana Nethralaya,
Bangalore, India
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
280
Tuesday – Posters – 4183 – 4201
4183 — D0097 Increased FXII activity in
vitreous of patients with Diabetic Macular
Edema (DME) and in animal models of VEGFand bradykinin-induced retinal edema. Tuna
Ustunkaya, N. Murugesan, A. C. Clermont, E. P.
Feener. Vascular Biology, Joslin Diabetes Center,
Boston, MA
4184 — D0098 In vitro effects of interleukin-6
on the outer blood-retinal barrier. Marina
Mesquida2, 1, P. J. Lait3, D. A. Copland3, J. Liu3,
V. Llorens1, M. Sainz De La Maza1, A. Adan
Civera1, A. D. Dick3, R. W. Lee3, 4, B. Molins2.
1
Ophthalmology, Hospital Clinic de Barcelona,
Barcelona, Spain; 2Fundació Clínic per a la
Recerca Biomèdica, Barcelona, Spain; 3School of
Clinical Sciences, University of Bristol, Bristol,
United Kingdom;4Biomedical Research Centre
at Moorfields Eye Hospital, National Institute for
Health Research, London, United Kingdom *CR
Exhibit/Poster Hall D0204-D0234
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Retinal Cell Biology / Glaucoma / Lens /
Nanotechnology and Regenerative Medicine
384 Müller Cells and Astrocytes In
Development and Disease
Moderator: Patrice E. Fort
4186 — D0205 Tumor suppressor p27KIP1
modulates cell-cycle entry and limited
neurogenic potential in radial Müller glia.
Edward Levine1, 2, D. M. Defoe3, F. Vazquez-Chona2.
1
Vanderbilt Eye Institute, Vanderbilt University,
Nashville, TN; 2Ophthalmology & Visual Sciences,
University of Utah, Salt Lake City, UT; 3Biomedical
Sciences, ETSU College of Medicine,
Johnson City, TN
4187 — D0206 Pharmacologic Inhibition
of Intermediate Filament Accumulation in
Astrocytes and Müller Glia Mediates Retinal
Neuroprotection. Jeremy M. Sivak1, 2, D. Chan1, 2,
X. Guo1, I. Livne-Bar3.1Vision Sciences, Krembil
Research Institute, University Health Network,
Toronto, ON, Canada; 2Vision Sciences and
Ophthalmology, University of Toronto, Toronto,
ON, Canada; 3School of Optometry, University of
California at Berkeley, Berkeley, CA *CR
4189 — D0208 The Role of Notch Signaling in
the Regenerating Adult Zebrafish Retina. Joshua
Hobgood. Biology, University of Notre Dame,
South Bend, IN
4190 — D0209 Changes in miRNAs in Müller
glia after retinal injury and Dicer deletion.
Stefanie G. Wohl, T. A. Reh. Biological Structure,
University of Washington, Seattle, WA
4191 — D0210 Müller cell processes occupy
the subretinal space in geographic atrophy
and Stargardt disease. Malia M. Edwards1, D.
McLeod1, I. A. Bhutto1, R. Grebe1, M. Villalonga3,
V. L. Bonilha2, J. G. Hollyfield2, J. M. Seddon3, 4,
G. A. Lutty1. 1Wilmer Eye Institute, Johns Hopkins
University School of Medicine, Baltimore, MD;
2
Cole Eye Institute, Cleveland Clinic, Cleveland,
OH; 3Ophthalmic Epidemiology and Genetics
Service, New England Eye Center, Tufts Medical
Center, Boston, MA; 4Ophthalmology, Tufts
University School of Medicine, Boston, MA
4192 — D0211 Gliotic remodeling in long-term
organotypic culture of the human retina. Arnold
Szabo1, M. Hudak1, A. Kusnyerik2, A. Lukats1,
Z. Nagy2, J. Nemeth2, A. Szel1. 1Department of
Human Morphology and Developmental Biology,
Semmelweis University, Budapest, Hungary;
2
Department of Ophthalmology, Semmelweis
University, Budapest, Hungary
4193 — D0212 Inhibition of Muller Cell
Circadian Rhythms by siRNA Knockdown of
Period Genes. Lili Xu2, A. Liu3, J. S. Penn1, D.
McMahon2. 1Ophthalmology, Vanderbilt University,
Nashville, TN;2Biological Sciences, Vanderbilt
University, Nashville, TN; 3Department of Biology,
University of Memphis, Memphis, TN
4194 — D0213 ChR2 Stimulation in Müller
cells Modulates the Retinal Light Response.
Cameron Baker, J. Tang, M. Berry, E. Isacoff, J.
G. Flannery. Technology, Univeristy California
Berkeley, Berkeley, CA
4195 — D0214 The role of FAK in fibrotic
matrix contraction by dedifferentiated Müller
cells. Rintaro Tsukahara1, K. Umazume2, N.
Yamakawa2, T. Iwasaki1, H. J. Kaplan3, H.
Goto2, S. Tamiya3, 4.1Ophthalmology, Tokyo
Med Univ, Ibaraki Med Ctr, Inashikigun, Japan;
2
Ophthalmology, Tokyo Med Univ, Shinjuku, Japan;
3
Ophthalmology and Visual Sciences, University
of Louisville, Louisville, KY; 4Biochemistry and
Molecular Biology, University of Louisville,
Louisville, KY
4196 — D0215 Role of Dexamethasone
preventing Müller glial cells swelling. Lourdes
M. Siqueiros1, 2, H. Charles-Messance1, R.
Bolanos3, 4, C. Montañez2, J. Sahel1, 5, A. Rendon1,
R. Tadayoni1, 6, A. Giocanti7. 1Institut de la Vision/
INSERM/UPMC Univ Paris 06/CNRS/CHNO
des Quinze-vingts, Paris, France; 2Genetics and
Molecular Biology, CINVESTAV, Mexico, Mexico;
3
Association to prevent blindness in Mexico, Dr.
Luis Sanchez Bulnes Hospital, Mexico, Mexico;
4
Ophthalmology, Regional Hospital, Adolfo López
Mateos, ISSSTE, Mexico, Mexico; 5Fondation
Ophtalmologique Adolphe de Rothschild, Paris,
France; 6Ophthalmology, Hôpital Lariboisière,
AP-HP, Univ Paris Diderot, Paris, France;
7
Ophthalmology, Avicenne hospital,
Bobigny, France
4197 — D0216 Coordinating reactive gliosis
and regeneration following damage to the adult
zebrafish retina. Ryan Thummel2, J. L. Thomas1,
A. H. Ranski2, G. W. Morgan3. 1Department of
Biological Structure, University of Washington,
Seattle, WA; 2Department of Anatomy/Cell Biology
and Ophthalmology, Wayne State University
School of Medicine, Detroit, MI; 3Department of
Biochemistry, University of Washington, Seattle, WA
4198 — D0217 Implication of
24-S-hydroxycholesterol in Müller glial cell’s
membrane dynamics in the rat. Arthur Ferrero1,
S. Gambert-Nicot2, N. Acar2, A. M. Bron1, 2, L.
Bretillon2, C. P. Garcher1, 2.1Ophthalmology,
University Hospital Dijon, France, Dijon, France;
2
CSGA, UMR1324 INRA, 6265 CNRS, Burgundy
University, Eye and Nutrition Research Group,
Dijon, France
4199 — D0218 The effect of systemic
administration of methylene blue and metformin
on photoreceptor degeneration caused by
selective Müller cell disruption. Weiyong Shen,
M. X. Yam, S. Lee, Y. Wang, S. Chung, L. Zhu, M.
C. Gillies. Save Sight Institute, The University of
Sydney, Sydney, NSW, Australia
4200 — D0219 The influence of X-box Binding
Protein 1 and the Unfolded Protein Response on
Müller glia differentiation into retinal neurons.
Todd McLaughlin1, 2, J. Yang1, 4, J. J. Wang1, 2, S.
X. Zhang1, 3. 1Departments of Ophthalmology and
Ross Eye Institute, University at Buffalo, State
University of New York, Buffalo, NY; 2SUNY Eye
Institute, State University of New York, Buffalo,
NY; 3Department of Biochemistry, University at
Buffalo, State University of New York, Buffalo,
NY; 4State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Center, Sun Yat-sen
University, Guangzhou, China
4201 — D0220 Retinal degeneration triggers
the activation of the Hippo pathway effector
gene YAP in reactive Müller cells. christel
Masson-Garcia, A. Hamon, J. Bitard, J. E. Roger,
M. Perron. Institute of Neuroscience, CNRS, Certo,
Orsay, France
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
281
Tuesday Posters
3:45 pm – 5:30 pm
4185 — D0204 Repopulation of the retina by
myeloid cells following depletion of endogenous
retinal microglia in adult mice. Yikui Zhang, L.
Zhao, X. Wang, R. N. Fariss, W. T. Wong. National
Eye Institute, Bethesda, MD
4188 — D0207 Effect of TNF-α on the
expression of glial fibrillary acidic protein
(GFAP) and on the photoreceptor differentiation
of human Müller glial stem cells in vitro. Erika
Aquino, K. Eastlake, A. Angbohang, P. T. Khaw,
G. Limb. NIHR Biomedical Research Centre for
Ophthalmology, UCL Institute of Ophthalmology
and Moorfields Eye Hospital, London,
United Kingdom
4202 – 4221 – Tuesday – Posters
4202 — D0221 Müller cell-derived YAP
signaling as a new neuroprotective pathway
in the degenerating retina. Annaïg Hamon2, 1, J.
E. Roger2, 1, J. Bitard2, 1, C. Masson-Garcia2, 1, E.
Grellier2, 1, M. Perron2, 1. 1Certo, Orsay, France;
2
Neuro-Psi, Orsay, France
4203 — D0222 Lin28a regulates retinal
neurogliogenesis and confers ectopic neural
potential on Müller glia. Xiaohuan Xia, I. Ahmad.
Ophthalmology and Visual Science, Univ of Neb
Med Center, Omaha, NE
Tuesday Posters
3:45 pm – 5:30 pm
4204 — D0223 Impact of a reduction of
plasmalogen levels on Müller cell metabolism.
Charlotte Pallot1, J. Mazzocco2, S. Gregoire2, L.
Leclere2, B. Buteau2, A. M. Bron1, 2, C. P. Garcher1, 2,
L. Bretillon2, N. Acar2. 1Ophthalmology, University
hospital, Dijon, France; 2INRA, Eye and Nutrition
research group, Dijon, France
4205 — D0224 Immunolocalization of Gap
Junction Protein Connexin 43 (GJA1) in retina
and Glial Müller Cells in WT and Dp-71 null
mice. Rodrigo Bolanos1, 2, L. M. SIQUEIROS3,
Y. Garfias4, 5, C. Montañez6, J. Sahel3, X. P.
Guillonneau3, A. Rendon3. 1Anterior Segment
Department, Association to Prevent Blindness in
Mexico, Dr Luis Sánchez Bulnes, Mexico, Mexico;
2
Ophthalmology Service, Regional Hospital,
Adolfo López Mateos, ISSSTE, Mexico, Mexico;
3
Laboratoire de Physiopathologie Cellulaire et
Moléculaire de la Rétine, Sorbonne Universités,
UPMC Univ Paris 06, INSERM, CNRS, Institut
de la Vision, Paris, France; 4Department of
Biochemistry, Faculty of Medicine. Universidad
Nacional Autónoma de México, UNAM., Mexico,
Mexico; 5Research Unit, Institute of Ophthalmology
“Conde de Valenciana”, Mexico, Mexico;
6
Department of Genetics and Molecular Biology,
CINVESTAV, Mexico, Mexico
4206 — D0225 Glucose effect on Rat and
Human Müller Cells Viability and VEGF
Secretion. Sandeep Vellanki1, A. Ferrigno2, Y.
Alanis1, B. S. Betts-Obregon1, A. T. Tsin1. 1Biology,
University of Texas at San Antonio, San Antonio,
TX; 2Escuela de Medicina, Tecnologico de
Monterrey, Monterrey, Mexico
4207 — D0226 Plasmalogens and cell-cell
communication between retinal glial cells. Julie
Mazzocco1, C. Pallot2, B. Buteau1, S. Gregoire1, L.
Leclere1, A. M. Bron2, C. P. Garcher2, L. Bretillon1,
N. Acar1.1Eye & Nutrition Research Group, Dijon,
France; 2ophthalmology, university hospital,
Dijon, France
4208 — D0227 Primary muller glial cultures
of primate origin. Shweta Singhal1, 2, V. Pakala2,
M. N. Mehta2, V. A. Barathi2, T. Wong1, 2. 1Singapore
National Eye Centre, Singapore, Singapore; 2Retina,
Singapore Eye Research Institute, Singapore,
Singapore
4209 — D0228 TRPV4 and TRPC1 channels
regulate strain sensitivity in retinal neurons and
glia. Andrew Jo, S. Redmon, A. Iuso, T. Molnar,
T. T. Phuong, D. Krizaj. Ophthalmology & Visual
Sciences, University of Utah, Salt Lake City, UT
4210 — D0229 Retinal Ganglion Cells
Control Spatial Patterning of Astrocytes During
Development. Matthew L. O’Sullivan1, J. A.
Brzezinski3, T. M. Glaser4, J. Kay1, 2. 1Neurobiology,
Duke University School of Medicine, Durham,
NC; 2Ophthalmology, Duke University School
of Medicine, Durham, NC; 3Ophthalmology,
University of Colorado School of Medicine, Aurora,
CO; 4Cell Biology and Human Anatomy, University
of California Davis School of Medicine, Davis, CA
4211 — D0230 Endothelin-1 Induced the
Reactivation of Primary Rat Ocular Astrocytes.
Shaoqing He1, H. Ma1, Y. H. Park1, J. Wang2,
T. Yorio1. 1North Texas Eye Research Institute,
University of North Texas Hlth Sci Ctr, Fort Worth,
TX; 2Depart. of Ophthalmology, TongJi Hospital,
Tongji Medical College, Huazhong University of
Science and Technology, Wuhan, China
4212 — D0231 Sigma-1 receptor mediated
secretion of BDNF by optic nerve head
astrocytes. Barbara A. Mysona1, 3, J. Zhao2, 3, S.
B. Smith1, 3, K. E. Bollinger2, 3. 1Department of
Cellular Biology and Anatomy, Augusta University,
Augusta, GA; 2Department of Ophthalmology,
Medical College of Georgia, Augusta, GA; 3James
and Jean Culver Vision Discovery Institute, Augusta
University, Augusta, GA
4213 — D0232 Retinal astrocytes protect
neurons against metabolic stress by inducing the
PI3K pathway. Samih Alqawlaq1, 2, I. Livne-Bar3,
D. Chan1, 2, J. M. Sivak1, 4. 1Department of vision
science, Krembil Research Institute, Toronto, ON,
Canada; 2Ophthalmology and Vision Science,
University of Toronto, Toronto, ON, Canada;
3
School of Optometry, University of California
Berkeley, Berkeley, CA; 4Laboratory of Medicine
and Pathobiology, University of Toronto, Toronto,
ON, Canada
4214 — D0233 A novel method to assess
astrocyte calcium in rat retina. Hui Li2, L. Wang1,
G. Cull1. 1Devers Eye Institute, Portland, OR;
2
Ophthalmology, Shanghai Tenth People’s Hospital,
Shanghai, China
4215 — D0234 Glial cells of the optic nerve
and Persistent Fetal Vasculature (PFV) disease.
Stacey L. Hose1, C. Zhang2, J. S. Zigler1, J. Qian1,
D. Sinha1. 1Ophthalmology, Johns Hopkins Wilmer
Eye Inst, Baltimore, MD; 2Montefiore Medical
Center, Albert Einstein College of Medicine,
Bronx, NY
Exhibit/Poster Hall D0251-D0307
Tuesday, May 03, 2016 3:45 PM-5:30 PM
Multidisciplinary Ophthalmic Imaging Group /
Anatomy and Pathology/Oncology
385 Clinical and Other Applications
of OCT
Moderators: Delia DeBuc and Brandon J. Lujan
4216 — D0251 Ganglion cell loss in early
Alzheimer’s disease: evidence in optical
coherence tomography. Cristina Castella1,
A. Saint-Jean1, M. Balasa2, B. Sanchez1.
1
Ophthalmology, CHU Nantes, Nantes, France;
2
Neurology, Hospital Clinic Barcelona, Barcelona,
Spain
4217 — D0252 Investigation of Retinal
thickness using OCT in Autism Spectrum
Disorder. Julie-Anne Little2, P. M. Anketell2, 1, L.
Doyle2, K. Saunders2. 1Belfast Health and Social
Care Trust, Belfast, United Kingdom; 2Biomedical
Sciences Research Institute, Ulster University,
Coleraine, United Kingdom
4218 — D0253 Optic Nerve Head Perfusion
and Retinal Structural Measurement by Optical
Coherence Tomography in Multiple Sclerosis.
Liang Liu1, S. Rebecca2, Y. Jia1, X. Zhang1, O. Tan1,
D. Huang1.1Casey Eye Institute, Oregon Health &
Science University, Portland, OR; 2Department of
Neurology, Portland VA Medical Center, Oregon
Health & Science University, Portland, OR *CR
4219 — D0254 Progressive loss of retinal
ganglion cells and RNFL in non-optic neuritis
eyes of multiple sclerosis patients - a longitudinal
study. Elizabeth C. Graham1, 2, Y. You1, 2, M. H.
Barnett3, J. Parratt3, C. Yiannikas3, A. Klistorner1, 2.
1
Ophthalmology, Sydney University, Gladesville,
NSW, Australia; 2Ophthalmology and Vision
Science, Macquarie University, Sydney, NSW,
Australia; 3Neurology, Sydney University, Sydney,
NSW, Australia
4220 — D0255 Longitudinal Follow-Up of
Papilledema by Optical Coherence Tomography
Macular Segmentation. Kim Jiramongkolchai1, T.
Bhatti1, I. Aboobakar1, C. Mehanna2, M. El-Dairi1.
1
Duke Eye Center, Duke University, Durham, NC;
2
Ophthalmology, American University of Beirut,
Beirut, Lebanon
4221 — D0256 Swept-source Optical
Coherence Tomography Angiography Features
in Behçet’s Uveitis. Salim Ben Yahia1, 2, N.
Abroug1, 2, S. Khochtali1, 2, R. Kahloun1, 2, B.
Jelliti1, 2, F. Nouira3, M. Khairallah1, 2. 1Department
of Ophthalmology, Fattouma Bourguiba University
Hospital, Monastir, Tunisia; 2Faculty of Medicine,
University of Monastir, Monastir, Tunisia; 3Laser
Center of Sousse, Sousse, Tunisia
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
282
Tuesday – Posters – 4222 – 4240
4222 — D0257 Inter-method agreement in
retinal blood vessels diameter analysis between
Dynamic Vessel Analyzer and Optical Coherence
Tomography. Maria Vittoria Cicinelli1, L.
Benatti1, L. Tomasso1, F. Corvi1, A. Mazzaferro2,
A. Carnevali3, I. Zucchiatti1, L. Querques1,
F. Bandello1, G. Querques1. 1Ophthalmology,
San Raffaele Scientific Institute, Milan, Italy;
2
Ophthalmology, University of Messina, Milan,
Italy;3ophthalmology, University of Magna Graecia,
Catanzaro, Italy
4223 — D0258 Structure-Function Analysis
in Chiasmal Compression Helps Predict Visual
Prognosis. Juthamat Witthayaweerasak1, 2,
M. Sun1, 3, A. Shariati1, J. Li1, Y. J. Liao1.
1
Ophthalmology, Stanford Medical Center, Stanford,
CA; 2Ophthalmology, Prince of Songkla University,
Hatyai, Thailand; 3Ophthalmology, Chang Gung
Memorial Hospital, Taoyuan, Taiwan
4225 — D0260 Ganglion Cell Complex
Thickness Distributions Measured with 3D OCT1 Maestro in Normal Eyes. Qi Yang, Y. Dong, W.
Huang, D. Leung, C. A. Reisman, K. Chan. Topcon
Advanced Biomedical Imaging Laboratory, Topcon
Medical Systems, Oakland, NJ *CR
4226 — D0261 Diagnostic accuracy of retinal
nerve fiber layer, macular ganglion cell complex
and optic nerve head measurements using
spectral-domain optical coherence tomography.
Frédéric Pollet-Villard, C. Chiquet, J. Romanet, F.
Aptel. Ophtalmology, Grenoble University Hospital,
Grenoble, France
4227 — D0262 In Vivo Assessment Of Optic
Nerve Head Pre-Laminar Neural Tissue
Thickness In Glaucoma: Diagnostic Performance
And Correlation With Conventional Parameters.
Bernardo de Padua Soares Bezerra1, F. S S Lopes2,
D. Torres Dias2, M. Ushida3, I. Matsubara3, F.
Nishimura Kanadani1, S. Dorairaj4, T. Santos
Prata2, 3. 1Glaucoma, instituto de Olhos Ciências
Médicas, Belo Horizonte, Brazil; 2Universidade
Federal de São Paulo, São Paulo, Brazil; 3Hospital
Medicina dos Olhos, Osasco, Brazil; 4Mayo Clinic,
Jacksonville, FL
4229 — D0264 Comparative Analysis: To assess
the level of agreement between PRIMUS (ZEISS
India) and CIRRUS (ZEISS Dublin CA) SDOCT Normative Database limits. Krunalkumar
Ramanbhai Patel1, G. T C1, S. Natesh2. 1Carin, Carl
Zeiss India, Bangalore, India; 2Nethra Eye Hospital,
Bangalore, India *CR
4230 — D0265 Ethnic Variation in optic disc
and macular structure by Optical Coherence
Tomography. Paolo Turchetti1, F. Pacella2, F.
Izzo1, C. Fazioli1, C. Mirisola1, S. Altimari1. 1INMPNIHMP, Rome, Italy; 2University Sapienza, Roma,
Italy
4231 — D0266 Assessment of eccentric
vitreous density in healthy subjects using optical
coherence tomography. Robert J. Barry1, 2, H.
Ibrahim1, T. Macdonald1, M. Allie6, P. I. Murray1,
6
, P. A. Keane3, T. Aslam4, 5, A. K. Denniston2, 1.
1
Academic Unit of Ophthalmology, University
of Birmingham, Birmingham, United Kingdom;
2
Department of Ophthalmology, University
Hospitals Birmingham NHS Foundation Trust,
Birmingham, United Kingdom; 3Department of
Ophthalmology, Moorfields Eye Hospital, London,
United Kingdom; 4Department of Ophthalmology,
Manchester Royal Eye Hospital, Manchester,
United Kingdom; 5University of Manchester,
Manchester, United Kingdom; 6Department of
Ophthalmology, Birmingham & Midland Eye
Centre, Birmingham, United Kingdom
4232 — D0267 Quantification of intraretinal
hard exudates with Enface Optic Coherence
Tomography. Sowmya Srinivas1, M. G. Nittala1, A.
H. Hariri1, M. Pfau1, J. Gasperini2, S. R. Sadda1.
1
Ophthalmology, Doheny Eye Institute, University
of California, Los Angeles, CA; 2Ophthalmology,
South coast retinal center, Long beach, CA *CR
4233 — D0268 Reduced Ganglion cell
volumetric assessment by spectral-domain
optical coherence tomography in patients with
Geographic Atrophy. Hema L. Ramkumar, Q. You,
D. G. Bartsch, W. R. Freeman. Ophthalmology,
University of California, San Diego, La Jolla, CA
4234 — D0269 Significance of Choroidal
Hyper-reflective foci visualised on
Enhanced Depth Imaging in Central Serous
Chorioretinopathy. Namritha V. Patrao2, D.
Menon2, M. Zola2, P. Sanghi1, L. Nicholson2, P.
Hykin2, S. Sivaprasad2. 1Institute of Ophthalmology,
University College of London, London, United
Kingdom; 2NIHR Moorfields Biomedical Research
Centre, London, United Kingdom *CR
4235 — D0270 Assessment of vitreous
inflammation before and after corticosteroid
therapy in patients with uveitic cystoid macular
edema using optical coherence tomography.
Hussein Ibrahim2, R. J. Barry2, 1, M. Allie3, P.
I. Murray2, 1, P. A. Keane4, T. Aslam5, 6, A. K.
Denniston1, 2. 1Department of Ophthalmology,
University Hospitals Birmingham NHS Foundation
Trust, Birmingham, United Kingdom; 2Academic
Unit of Ophthalmology, University of Birmingham,
Birmingham, United Kingdom; 3Department
of Visual Function, Birmingham and Midland
Eye Centre, Birmingham, United Kingdom;
4
Department of Ophthalmology, Moorfields Eye
Hospital, London, United Kingdom; 5Department
of Ophthalmology, Manchester Royal Eye Hospital,
Manchester, United Kingdom; 6University of
Manchester, Manchester, United Kingdom
4236 — D0271 Comparison of retinal ganglion
cell - inner plexiform layer thickness measured
by Cirrus and Spectralis optical coherence
tomography in eyes with diabetic macular
edema. Julia Hafner, S. G. Prager, J. Lammer,
K. Kriechbaum, C. Scholda, U. Schmidt-Erfurth.
Ophthalmology and Optometry, Medical University
Vienna, Austria, Vienna, Austria
4237 — D0272 Retinal thickness irregularities
in preclinical diabetic retinopathy. Alan Poon1, 2,
T. Wright2, A. Dupuis5, 3, C. A. Westall2, 4. 1Institute
of Medical Science, University of Toronto, Toronto,
ON, Canada; 2Ophthalmology and Vision Sciences,
The Hospital for Sick Children, Toronto, ON,
Canada; 3Dalla Lana School of Public Health,
University of Toronto, Toronto, ON, Canada;
4
Ophthalmology and Vision Sciences, University of
Toronto, Toronto, ON, Canada; 5Clinical Research
Services, The Hospital for Sick Children, Toronto,
ON, Canada
4238 — D0273 Type 2 diabetes mellitus
patients with white dots in the central fundus
and neuroretinal degeneration. Stanley Darma1,
R. O. Schlingemann1, P. Kok1, M. D. Abramoff3,
F. Holleman2, F. D. Verbraak1, 4. 1Ophthalmology,
Academic Medical Center, Amsterdam,
Netherlands; 2Internal Medicine, Academic Medical
Centre, Amsterdam, Netherlands; 3Ophthalmology
and Visual Sciences, University of Iowa, Iowa City,
IA;4Biomedical Engineering and Physics, Academic
Medical Centre, Amsterdam, Netherlands
4239 — D0274 Perifoveal vessels and
structural changes visualized in deeper layers of
diabetic retinas. Edmund Arthur, J. A. Papay, B.
P. Haggerty, C. A. Clark, A. E. Elsner. School of
Optometry, Indiana University, Bloomington, IN
4240 — D0275 A Novel Spectral Domain
Optical Coherence Tomography (SD-OCT)
Classification Scheme for the Differential
Diagnosis of Macular Edema of Diabetic and
Retinal Veno-Occlusive Origin. Mikel Mikhail,
R. Coussa, D. E. Lederer. McGill University,
Montreal, QC, Canada
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
283
Tuesday Posters
3:45 pm – 5:30 pm
4224 — D0259 The eye as a window to the
brain. Retinal structure is associated with
cerebral injury in HIV-infected children. Frank
D. Verbraak1, N. Demirkaya1, C. Blokhuis2, S.
Cohen2, F. Wit3, 4, M. Caan5, H. Scherpbier2, M. D.
Abramoff6, 7, D. Pajkrt2. 1Ophthalmology, Academic
Medical Center, Amsterdam, Netherlands;
2
Pediatric Infectious Diseases, Emma Children’s
Hospital, Amsterdam, Netherlands; 3Infectious
Diseases, Academic Medical Center, Amsterdam,
Netherlands; 4Amsterdam Institute for Global
Health ans Development, Amsterdam, Netherlands;
5
MRI, Academic Medical Center, Amsterdam,
Netherlands; 6Ophthalmology and Visual Science,
University of Iowa, Iowa, IA; 7Biomedical
Engineering, Iowa Institute for Biomedical Imaging,
Iowa, IA
4228 — D0263 Diurnal variation in summary
measures and inter-visit test-retest variability
of standard automated perimetry and spectral
domain optical coherence tomography. John
Pearce, T. Maddess. John Curtin School of Medical
Research, Australian National University, Canberra,
ACT, Australia *CR
4241 – 4263 – Tuesday – Posters
4241 — D0276 Preoperative Optical Coherence
Tomography Findings in Macular Epiretinal
Membrane. Miyu Ichida, Y. Hirano, N. Suzuki, T.
Tomiyasu, T. Yasukawa, Y. Ogura. Department of
Ophthalmology and Visual Science, Nagoya City
University Graduate School of Medical Sciences,
Nagoya, Japan
4242 — D0277 Selective Depletion Of Ganglion
Cells Layer In Unaffected Fellow Eye Of Patients
With Idiopathic Epiretinal Membranes In
Controlateral Eye. Andrea M. Coppe, G. Lapucci,
G. Ripandelli. GB Foundation Study Ophth IRCCS,
Rome, Italy
4243 — D0278 Radial symmetry of the foveal
pit curvature assessed with optical coherence
tomography. Dean A. VanNasdale, A. Eilerman.
Optimedica, Ohio State Univ College of Optometry,
Columbus, OH
Tuesday Posters
3:45 pm – 5:30 pm
4244 — D0279 Location of foveola relative to
optic nerve head in healthy eyes using spectral
domain optical coherence tomography (SDOCT). Robert A. Sharpe, D. Williams, R. H. Trivedi,
J. Blice. Ophthalmology, Medical University of
South Carolina, Charleston, SC
4245 — D0280 Axonal pore paths get closer
to the optic nerve center with increased depth
through the lamina cribrosa. Zachary M. Dong1,
B. Wang1, 2, J. S. Schuman1, 2, K. Lucy1, R. A.
Bilonick1, 3, C. D. Lu4, I. A. Sigal1, 2, L. Kagemann1, 2,
J. G. Fujimoto4, H. Ishikawa1, 2, G. Wollstein1, 2.
1
UPMC Eye Center, Eye and Ear Institute,
Department of Ophthalmology, University of
Pittsburgh School of Medicine, Ophthalmology and
Visual Science Research Center, Pittsburgh, PA;
2
Department of Bioengineering, Swanson School of
Engineering, University of Pittsburgh, Pittsburgh,
PA; 3Department of Biostatistics, University of
Pittsburgh School of Public Health, Pittsburgh,
PA; 4Department of Electrical Engineering and
Computer Science, Massachusetts Institute of
Technology, Cambridge, MA
4246 — D0281 Optical Coherence Tomography
Minimum Intensity Abnormalities in
Hydroxychloroquine Toxicity. Paul F. Stetson1,
A. M. Allahdina2, S. Vitale2, C. Cukras2. 1Research
and Development, Carl Zeiss Meditec, Dublin, CA;
2
National Eye Institute, Bethesda, MD *CR, f
4247 — D0282 Outer retinal reflectivity on
En-face OCT as a new tool to detect early stage
hydroxychloroquine maculopathy. Adrien Viotte,
G. Bigan, M. Flores, C. Girard, B. Y. Delbosc, M.
Saleh. ophtalmology, CHU Besançon,
Besançon, France
4248 — D0283 Photoreceptor anisotropy in
macular oedema and MacTel : a multiangle OCT
study. Alexandre Pedinielli1, M. Laguarrigue2, S.
Mrejen2, F. Rossant2, R. Tadayoni1, A. Gaudric1, V.
Krivosic1, M. Paques2. 1Ophthalmology, Hôpital
Lariboisière, Paris, France; 2Quinze-Vingts
Hospital, Paris, France
4249 — D0284 Compartmentalization of
intraretinal empty spaces in MacTel by SS OCT.
Pascal W. Hasler, C. Gyger, P. Maloca. Eye Clinic,
University Hospital Basel, Arlesheim, Switzerland
*CR
4250 — D0285 Altered Photoreceptor Bands
Surrounding Areas of Loss in MacTel Cause
En Face OCT Endpoint Variability. Brandon
J. Lujan1, 2, E. Y. Chew3, J. L. Duncan4, B. J.
Antony1, 5, V. Makhijani1, 6, A. Roorda1. 1School
of Optometry and Vision Science Graduate
Program, University of California, Berkeley,
Berkeley, CA; 2Ophthalmology, Casey Eye
Institute, OHSU, Portland, OR; 3Epidemiology
and Clinical Applications, National Eye Institute/
National Institutes of Health, Bethesda, MD;
4
Ophthalmology, University of California, San
Francisco, San Francisco, CA; 5Electrical &
Computer Engineering, Johns Hopkins University,
Baltimore, MD; 6Ophthlalmology, Bronx-Lebanon
Hospital, Bronx, NY *CR
4251 — D0286 Ocular Coherence Tomography
Used to Support an Investigational New
Drug Application for a C3 Complement
Inhibitor Targeting Macular Degeneration.
Margaret E. Collins1, J. S. Slakter2, R. Munger3,
P. Wells1, C. Kolodziej1, P. Deschatelets4, R.
Stoll5. 1Ophthalmology, Charles River, Reno,
NV; 2NYU Medical School, Great Neck, NY;
3
Animal Ophthalmology, Dallas, TX; 4Potentia
Pharmaceuticals, Inc, Crestwood, KY; 5Stoll &
Associates, Storrs Mansfield, CT *CR
4252 — D0287 Measurement of macular hole
dimensions by OCT shadowgraphy. Saruban
Pasu, P. Tanna, J. W. Bainbridge. Moorfields Eye
Hopsital, London, United Kingdom
4253 — D0288 En Face Spectral-Domain
Optical Coherence Tomography Imaging of
Photoreceptor Layer in Repaired Macular Hole.
Yonguk Kim, H. Kwak, S. Yu. Ophthalmology,
Kyung Hee University Hospital, Seoul, Korea
(the Republic of) *CR
4254 — D0289 Ocular Coherence Tomographic
Imaging in Patients with Recurrent Full
Thickness Macular Holes. Eli Levitt, G. Yu, A.
Bassiri, J. G. Arroyo. Eye, Beth Israel Deaconess
Medical Center, Coral Gables, FL
4255 — D0290 Comparison of Corneal
Topography, Optic Coherence Tomography,
Macula Pigment Optic Density of High Myopic
Eyes And Emmetropic Eyes in Terms of Visual
Acuity, Axial Length, Posterior Segment Signs.
Zeliha Yazar, A. Metin Kayhan. Ophthalmology,
Ankara Numune Edu & Rsrch Hosp, Ankara, Turkey
4257 — D0292 A New Quantitative
Approach in Analyzing Polypoidal Choroidal
Vasculopathy In Vivo Using En Face Optical
Coherence Tomography. Jonathan Chou1, E.
Chan2, J. Simonett3, A. A. Fawzi3. 1Ophthalmology,
Massachusetts Eye & Ear Infirmary, Cambridge,
MA; 2Ophthalmology, National University
Hospital, Singapore, Singapore; 3Ophthalmology,
Northwestern University, Chicago, IL
4258 — D0293 Optical Coherence Tomography
in the Evaluation of Neovascular Lesions
and Serous Pigment Epithelial Detachments
in Polypoidal Choroidal Vasculopathy. Eric
Weinlander, A. Domalpally, E. Corkery, B. A. Blodi.
Ophthalmology and Visual Sciences, University of
Wisconsin School of Medicine, Madison, WI
4259 — D0294 Correlation of Indocyanine
Green Angiography and Optical Coherence
Tomography in Polypoidal Choroidal
Vasculopathy. Tarek Alasil1, N. M. sanz2, P. A.
Keane2, P. Coady1, A. Tufail2, R. A. Adelman1.
1
Ophthalmology and Visual Sciences, Yale
University, New Haven, CT; 2Ophthalmology and
Visual Sciences, Moorfields Eye Hospital, London,
United Kingdom
4260 — D0295 Optical Density of Subretinal
Fluid in Proliferative Vitreoretinopathy. Rayan
Alshareef, V. Sun, A. Dan, M. Kapusta. School of
Medicine, McGill University, Montreal,
QC, Canada
4261 — D0296 Multicolor and Optical
Coherence Tomography Appraisal of Deep
Retinal Capillary Ischemia. Rosa Dolz-Marco2, 1,
L. Monje-Fernandez1, 3, M. Andreu-Fenoll1, 2, N.
Garcia-Marin1, R. Gallego-Pinazo1, 4. 1Macula
Unit, University and Polytechnic Hospital La Fe,
Valencia, Spain; 2Institute for Health Research,
University and Polytechnic Hospital La Fe, Spain,
Valencia, Spain; 3University Hospital Complex of
León, Leon, Spain; 4Retics Oftared (RD12/0034);
Prevention, Early Detection And Treatment Of
The Prevalent Degenerative And Chronic Ocular
Pathology, Institute of Health Carlos III,
Madrid, Spain *CR
4262 — D0297 Swept Source OCT Imaging
of Retinal Colobomas. Kelly Rue, A. Y. Kim,
H. A. Aziz, L. C. Olmos. Ophthalmology, USC,
Los Angeles, CA *CR
4263 — D0298 Spectral Domain Optical
Coherence Tomography Imaging of Subretinal
Bands Associated with Chronic Retinal
Detachment. Nikisha Kothari, A. Kuriyan, H.
W. Flynn. Ophthalmology, Bascom Palmer Eye
Institute, Miami, FL
4256 — D0291 Spectral-Domain Optical
Coherence Tomography Findings in
Peters’Anomaly infants. Jiaxu Hong1, X. Sun1,
R. Dana2, J. Xu1. 1Ophthalmology, Eye & Ear,
Nose, Throat Hospital, Shanghai, China; 2Harvard
Medical School, Boston, MA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
284
Tuesday – Posters – 4264 – 4272
4264 — D0299 Limitations of Retinal
Thickness Analysis in Cross-Sectional Data.
Daniel Rock3, L. Marahrens3, R. Kern1, T.
Ziemssen1, A. Fritsche2, F. Ziemssen3. 1Department
of Neurology, University Hospital Carl Gustav
Carus at the Dresden University of Technology,
Dresden, Germany, Dresden, Germany;
2
Department of Internal Medicine, Eberhard Karls
University, Tuebingen, Germany, Tuebingen,
Germany; 3Center for Ophthalmology, Eberhard
Karls University, Tuebingen, Germany, Tuebingen,
Germany *CR
4265 — D0300 3D diagnostic imaging of
retinoblastoma with a novel optical coherence
tomography clinical system. Oleg Nadiarnykh1,
A. Moll2, J. F. De Boer1. 1Physics, Vrije University,
Amsterdam, Netherlands; 2Ophthalmology,
VU University Medical Center, Amsterdam,
Netherlands *CR
4266 — D0301 Diagnosing senile Retinoschisis,
SD-OCT versus ultrasound echography
examination. Arne Bringewatt, S. Burzer, N.
Feucht, C. P. lohmann, M. M. Maier. Department of
Ophthalmology, Klinikum rechts der Isar, Munich,
Germany
4271 — D0306 The impact of swept-source
optical coherence tomography (SS-OCT) in
the management of scleral inflammation. Maite
Sainz De La Maza, M. Hereu, M. Hernandez,
M. Mesquida, V. Llorenç, A. Sala-Puigdollers, J.
Matas, B. Molins, A. Adan Civera, J. ZarranzVentura. Clinic Institute of Ophthalmology, Hospital
Clinic of Barcelona, Barcelona, Spain
4272 — D0307 Scleral toricity measurement
with 1050 nm Swept-Source Optical Coherence
Tomography. Ahmed M. Hagag1, 2, M. Tang1, Y.
Li1, D. Huang1. 1Department of Ophthalmology,
Oregon Health and Science University, Portland,
OR; 2Mansoura Faculty of Medicine, Mansoura,
Egypt *CR
Tuesday Posters
3:45 pm – 5:30 pm
4267 — D0302 Spectral domain optical
coherence tomography measurement of the
retinal pigment epithelium and Bruch’s
membrane complex thickness, and its
associations in a large population cohort,
UK Biobank. Zaynah A. Muthy2, 1, F. Ko2, 1, P.
J. Foster2, 1, N. G. Strouthidis2, 1, Q. Yang5, C.
A. Reisman5, U. Chakravarthy3, A. J. Lotery4,
A. Tufail1, 2, P. A. Keane1, 2, P. J. Patel2, 1. 1UCL
Institute Of Ophthalmology, London, United
Kingdom; 2NIHR Biomedical Research Centre,
Moorfields Eye Hospital, London, United Kingdom;
3
Optometry & Vision Science, Queens University of
Belfast, Belfast, United Kingdom;4Ophthalmology,
Southampton General Hospital, Hampshire, United
Kingdom; 5Topcon Advanced Biomedical Imaging
Laboratory, Oakland, NJ *CR
4270 — D0305 SD-OCT Assessment of Retinal
Structure After Subretinal Implantation of
a Substrate-Adherent Monolayer of Human
Embryonic Stem Cell-Derived Retinal Pigment
Epithelium. Ana Martynova5, A. H. Kashani5,
R. A. Brant1, M. Koss2, D. Zhu4, D. R. Hinton4,
D. O. Clegg3, M. S. Humayun5. 1Department of
Ophthalmology, UNIFESP Hospital Sao Paulo,
Sao Paulo, Brazil; 2Ophthalmology, University
of Heidelberg, Heidelberg, Germany; 3Molecular,
Cellular and Developmental Biology, University
of California, Santa Barbara, Santa Barbara, CA;
4
Pathology, University of Southern California,
Los Angeles, CA; 5Ophthalmology, University of
Southern California, Los Angeles, CA *CR
4268 — D0303 Visualization of the Macula
in Gas-filled Eyes using Swept-Source
Optical Coherence Tomography: Comparison
with Spectral-Domain Optical Coherence
Tomography. Byung Ro Lee, S. Ahn, S. Park.
Ophthalmology, Hanyang Univ Hosp, Seoul
4269 — D0304 Monitoring X-Linked
Retinoschisis (XLRS) by Optical Coherence
Tomography (OCT). Emily A. Swanson, R. J.
Munro, L. Ambrosio, T. S. Bowe, A. Moskowitz,
R. M. Hansen, J. D. Akula, A. B. Fulton.
Ophthalmology, Boston Children’s Hospital,
Boston, MA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
285
4273a – 4273h – Tuesday – ARVO/Champalimaud Lecture
Room 6B
Tuesday, May 03, 2016 5:45 PM-7:00 PM
386 ARVO/Champalimaud Award
Lecture - Strengthening eye care
services across Africa: The KCCO/
Seva Canada/Seva Foundation Project
The António Champalimaud Vision Award,
established by the Champalimaud Foundation
in 2006, honors outstanding contributions to the
preservation and understanding of sight.
Vision loss remains a significant problem in subSaharan Africa. In the last 15 years there has been
considerable work that provides eye care providers
with some of the evidence necessary to inform
practices, programmes, and policies. First, the
presentation will cover our growing understanding
of the epidemiology of vision loss and major causes
as well as the major challenges faced. Second,
based upon work throughout Africa (and other
places) the factors that are associated with improved
eye care service delivery will be reviewed. Third,
new socio-entrepreneurial models and their impact
will be reviewed. Fourth, the evidence for action
related to human resources for eye health will be
covered. The final section of the talk will cover
continuing challenges and the operational research
needs.
Tuesday, Lecture
5:45 pm – 7:00 pm
4273a — 5:45 Panelist discussion. Paul
Courtright. Kilimanjaro Centre for Community
Ophthalmology
4273b — 5:45 Panelist discussion. Susan
Lewallen. Kilimanjaro Centre for Community
Ophthalmology
4273c — 6:00 Panelist discussion. Heidi Chase.
Seva Foundation
4273d — 6:15 Panelist discussion. Suzanne
Gilbert. Seva Foundation
4273e — 6:30 Panelist discussion. Penny Lyons.
Seva Canada
4273f — 6:45 Panelist discussion. Ken Bassett.
Seva Canada
4273g — 6:45 Panelist discussion. Gerald
Msukwa. Visiting Ophthalmologist
4273h — 6:45 Panelist discussion. Levi Kendeke.
Visiting Ophthalmologist
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
286