Tuesday

Transcription

Tuesday

Tuesday
May 6, 2014
LEADING EYE AND VISION RESEARCH
MAY 4 – 8 | ORLANDO, FLORIDA
105
196
302 Structure function [GL] #2644-2650
303 New Perspectives on Color Vision
— Minisymposium [VI, BI, PH, VN]
#2651-2656
304 Eye movements [EY, CL] #2657-2663 #323 General
Business Meeting
305 Neuroprotection [GL] #2664 – 2670
306 Stem Cells: Biology and Therapeutic
Applications [RC] #2671-2677
S 230A-D
S 230EF
S 230GH
S 310A-D
S 310E-H
334 Dry Eye Disease [CO] #3054-3060
S 331A-D
310 Cornea surgery, non-refractive [CO]
#2697-2703
333 The Microbiome of the Eye and
Beyond — How the Microbiome Influences
Resistance against Opportunistic Pathogens
— Minisymposium [IM, CO, RC] #3049-3053
331 Myopia [AP] #3035-3041
S 330GH
309 New Insights into the Anatomy
of Blood and Lymphatic Vasculature
of the Eye — Minisymposium [AP]
#2691-2696
S 330CD
330 Phototransduction [BI, VN] #3028-3034
332 PCO [LE] #3042-3048
308 Mechanisms in retinal degeneration
[BI] #2685-2690
S 320GH
329 Physiology / Pharmacology [PH] #30213027
328 Mechanisms in retinal angiogenesis and
retinopathy [RC] #3014-3020
327 Visual fields and visual function [GL]
#3007-3013
326 Spatial vision [VI] #3000-3006
325 Early AMD [RE] #2993-2999
324 Keratoconus, biomechanics and
keratoprosthesis [CO] #2986-2992
335 Real life management of retinal disease
[RE] #3061-3067
11am–12:45pm
S 330EF
307 Life-and-death consequences of
visual impairment [CL] #2678-2684
S 320CD
S 320AB
301 Bipolar and amacrine cells [VN]
#2637-2643
S 210DE
10:15–10:55am
311 Novel Approaches for Retinal
Drug and Gene Delivery — TVST
Minisymposium [RE, PH] #2704-2710
8:30–10:15am
Hall SB
Room
Tuesday, May 6
361 Contributions of neuronal and vascular
defects to early diabetic retinopathy — SIG
360 Non-Invasive Targeted Molecular
Imaging in the Living Eye — SIG
359 Long term career considerations for
graduate students — SIG
354 The Symbiosis of Global Eye Research:
Building Bridges between the Developed
and Developing Worlds
358 Nuclear receptors (NRs) in retinal
development and disease: identifying
new signaling pathways with therapeutic
potential — SIG
357 Managing Patients with Diabetic
Macular Edema, Neovascular AMD, or
Retinal Vein Occlusion: How to Best Utilize
Data from Clinical Trials — SIG
356 RPE autofluorescence in a new light—
(SIG)
353 NIH-CSR Peer Review Workshop
352 Safely Taking Risks in Public and
Patient Involvement
355 En Face OCT imaging of the Eye —
SIG
351 Low Vision Group: Binocular Vision
Meets Low Vision [LV]
1–2:30pm
Workshop/SIG
373 Corneal endothelium [CO] #35803586
372 Inflammatory Tissue Damage and
Immunoregulation [IM] #3573-3579
371 Lens cell survival, development, and
aging [LE] #3566-3572
370 Eye-Health and Nutrition: From
Cradle to Grave — Minisymposium [CL]
#3560-3565
369 Pathophysiology of AMD and
retinopathies [RC] #3553-3559
368 Glaucoma pharmacology and clinical
studies [GL] #3546-3552
367 Neuro-ophthalmology [EY]
#3539-3545
366 Visual function in eye disease [VI]
#3533-3538
365 Drusen and drusenoid structures
[RE] #3526-3532
364 Leading Edge — New Directions in
the Analysis of Retinal Image Motion
— Minisymposium [VN] #3521-3525
3:45 –5:30pm
385 Where Are the
Women? Exploring
Roles in ARVO 40074013
6th Annual
WEAVR Luncheon
1:00 – 2:30pm
Level 1/South Hall B
(tickets required)
WEAVR
Silent Auction
9:30am – 3:45pm
Level 1/South Hall A
NAEVR Central
in ARVO Central
9am – 4pm
Exhibit Hall
9am – 4pm
with optional exhibit
hours
7:30 – 9am and
4 – 5:30pm
5:30–7pm
197
Oculoplastics [EY]
Cataract surgery II [LE]
Clinical and Translational Studies in Ocular
Infection and Immunity [IM, CO, RE]
Posterior Segment Infection and Inflammation #1 [IM]
Intraocular pressure / Aqueous humour dynamics [PH]
Blood flow [GL]
RPE/Retina Cell Biology and Degeneration, II [RC]
315
316
317
318
319
320
321
Non-melanoma intraocular lesions:
Retinoblastoma and beyond [AP, RE, RC]
Eyelids/Ptosis/Oculoplastics [EY]
Penetrating keratoplasty and other [CO]
Surgery and wound healing [GL]
Immunology, angiogenesis and genetics [CO]
Genetics II: Genetics of Retinal Degenerations and
Dystrophies [GEN, RE, RC]
Gene Therapy and Delivery [PH]
OCT imaging - Clinical studies of choroid [MOI, RE, RC]
OCT imaging - Clinical studies of retina [MOI, RE, RC]
Posterior Segment Imaging [RE, MOI]
AMD: Mechanism and Protection [RC, RE]
Retinoids, Carotenoids and Macular Pigment [BI, CL, RE]
ERG and VEP: human studies [VN]
Retinal Development [VN]
336
337
338
339
340
341
342
343
344
345
346
347
348
349
Session
Title
Conjunctiva biology and disease, ocular surface
health and disease 2 [CO]
314
Session
Number
Vision testing in children [VI]
11am–12:45pm
Refractive Error [VI]
313
Session
Title
8:30–10:15am
312
Session
Number
Tuesday, May 6 n Posters
3512-3520
3493-3511
3466-3492
3432-3465
3398-3431
3359-3397
3341-3358
3295-3340
3251-3294
3209-3250
3152-3208
3121-3151
3103-3120
3068-3102
Program
Number
2950-2985
2917-2949
2883-2916
2866-2882
2817-2865
2794-2816
2776-2793
2749-2775
2736-2748
2711-2735
Program
Number
(D0112-D0120)
(D0093-D0111)
(D0066-D0092)
(C0280-C0313)
(C0091-C0124)
(C0052-C0090)
(C0034-C0051)
(B0235-B0280)
(B0191-B0234)
(B0116-B0157)
(A0322-A0378)
(A0291-A0321)
(A0273-A0290)
(A0001-A0035)
Board
Number
(D0001-D0036)
(C0001-C0033)
(B0281-B0314)
(B0099-B0115)
(B0050-B0098)
(A0379-A0401)
(A0255-A0272)
(A0131-A0157)
(A0118-A0130)
(A0093-A0117)
Board
Number
Corneal biomechanics and keratoprosthesis [CO]
IOL and Accomodation [VI, LE]
Glaucoma genetics [GL]
377
378
379
3978-4006
3921-3977
3864-3920
3846-3863
(D0037-D0065)
(C0223-C0279)
(C0166-C0222)
(C0148-C0165)
(C0125-C0147)
(B0158-B0190)
(B0001-B0049)
(A0213-A0254)
(A0158-A0212)
(A0064-A0092)
(A0036-A0063)
Board
Number
Poster board numbers correspond to poster location in Level 1/South Hall A
A = Poster Area A , B = Poster Area B , C = Poster Area C and D =Poster Area D
Stem Cell II: Restoration of Photoreceptors [RC, RE]
CNV Management [RE]
Retinal and choroidal vascular diseases [RE, MOI, RC, PH]
Endophthalmitis and trauma [RE]
3823-3845
3790-3822
3741-3789
3699-3740
3644-3698
3615-3643
3587-3614
Program
Number
2:45–3:45pm: All Posters and Networking — authors will be present at poster
boards
1-2:30pm: MIT Outstanding Poster Award Session and Judging
(Room S 320EF)
384
383
382
381
Retinal disorders and management [RE]
Dry Eye Disease #2 [CO]
376
380
Myopia [AP]
Myopia - prevalence, risk factors, and possible
treatments [CL, VI]
374
Session
Title
375
Session
Number
3:45–5:30pm
NOTES
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198
Tuesday – Papers/Minisymposium – 2637 – 2650
S 210DE
S 230A-D
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Visual Neuroscience
Glaucoma
301 Bipolar and amacrine cells
302 Structure function
Moderators: Erika D. Eggers and
Kirill A. Martemyanov
Moderators: Balwantray C. Chauhan, David F.
Garway-Heath and Christopher Bowd
2637 — 8:30 The Atrx Chromatin Remodeler is
Required in Retinal Bipolar Cells for Amacrine
and Horizontal Cell Survival. Pamela S. Lagali1, 2,
C. Medina1, 2, K. Yan1, A. Baker1, S. G. Coupland3, 4,
V. A. Wallace1, 2, D. Picketts1, 2. 1Regenerative
Medicine, Ottawa Hospital Research Institute,
Ottawa, ON, Canada; 2Biochemistry, Microbiology
and Immunology, University of Ottawa,
Ottawa, ON, Canada; 3Cellular and Molecular
Medicine, University of Ottawa, Ottawa, ON,
Canada; 4Ophthalmology, University of Ottawa Eye
Institute, Ottawa, ON, Canada
2644 — 8:30 Evidence of axonopathy during
early-stage experimental glaucoma: relationship
between in vivo imaging and histological
findings. Brad Fortune1, 3, T. A. Lusardi2, 3, J.
Reynaud1, 3, T. E. Choe1, 3, C. Piper1, 3, G. Cull1, 3,
C. Burgoyne1, 3, L. Wang1, 3. 1Discoveries in Sight
Research Laboratories, Devers Eye Institute,
Legacy Health, Portland, OR; 2Robert Stone
Dow Neurobiology Laboratories, Legacy Health,
Portland, OR; 3Legacy Research Institute, Legacy
Health, Portland, OR *CR
2639 — 9:00 A Synaptic Basis for Small World
Network Design in the ON Inner Plexiform
Layer of the Rabbit Retina. J Scott Lauritzen,
N. T. Nelson, C. L. Sigulinsky, N. Sherbotie, J.
Hoang, R. L. Pfeiffer, J. R. Anderson, C. B. Watt,
B. W. Jones, R. E. Marc. Ophthalmology & Visual
Sciences, University of Utah, Salt Lake City,
UT *CR
2640 — 9:15 A non-spiking, wide-field
amacrine cell that rapidly integrates visual
signals over long distances in the primate.
Michael B. Manookin1, C. Puller1, F. Rieke2, M.
Neitz1, J. Neitz1. 1Ophthalmology, University
of Washington, Seattle, WA; 2Physiology and
Biophysics and HHMI, University of Washington,
Seattle, WA
2641 — 9:30 Cocaine- and amphetamineregulated transcript (CART): a novel retinal
neuropeptide. S. Anna Sargsyan, P. Iuvone.
Ophthalmology, Emory University, Atlanta, GA
2642 — 9:45 Cellular localization and rhythmic
expression of melatonin receptor 1 in the rat
retina. Shi-Jun Weng, W. Sheng, X. Yang, Y.
Zhong. Fudan University, Shanghai, China
2645 — 8:45 Longitudinal Evaluation of
Structural and Functional Progression in
Glaucoma with 10-Year Follow-Up. Xuejiao
Yang1, 2, G. Wollstein1, I. I. Bussel1, Y. Ling1, 3, R.
A. Bilonick1, 3, H. Ishikawa1, 4, L. Kagemann1, 4, C.
Mattox5, J. G. Fujimoto6, J. S. Schuman1, 4. 1UPMC
Eye Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh,
Pittsburgh, PA; 2State Key Laboratory of
Ophthalmology, Zhongshan Ophthalmic Center,Sun
Yat-sen University, Guangzhou, China; 3Department
of Biostatistics, Graduate School of Public
Health, University of Pittsburgh, Pittsburgh,
PA; 4Department of Bioengineering, Swanson
School of Engineering, University of Pittsburgh,
Pittsburgh, PA; 5New England Eye Center, Tufts
Medical Center, Boston, MA; 6Department of
Electrical Engineering and Computer Science,
Massachusetts Institute of Technology, Cambridge,
MA *CR
2646 — 9:00 Structural and Metabolic
Correlates of Transsynaptic Neurodegeneration
with Eye Morphology and Visual Function in
Glaucoma. Jesse D. Lawrence1, I. P. Conner2, 3, L.
C. Ho1, S. Kim1, 3, G. Wollstein2, J. S. Schuman2, 3,
K. C. Chan1, 2. 1NeuroImaging Laboratory,
Department of Radiology, University of Pittsburgh,
Pittsburgh, PA; 2UPMC Eye Center, Eye and Ear
Institute, Ophthalmology and Visual Science
Research Center, Department of Ophthalmology,
University of Pittsburgh, Pittsburgh,
PA; 3Department of Bioengineering, University of
Pittsburgh, Pittsburgh, PA *CR
2648 — 9:30 Does Glaucomatous Structural
Damage Indeed Precede Functional Deficit? An
Extended Long-Term Cohort Perspective. Divya
Narendra1, G. Wollstein1, D. Foote1, Y. Ling1, 2, R.
A. Bilonick1, 2, H. Ishikawa1, 3, L. Kagemann1, 3, C.
Mattox4, J. G. Fujimoto5, J. S. Schuman1, 3. 1UPMC
Eye Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh
School of Medicine, Pittsburgh, PA; 2Department
of Biostatistics, Graduate School of Public
Health, University of Pittsburgh, Pittsburgh, PA;
3
Department of Bioengineering, Swanson School of
Engineering, University of Pittsburgh, Pittsburgh,
PA; 4New England Eye Center, Tufts Medical
Center, Boston, MA; 5Department of Electrical
Engineering and Computer Science, Massachusetts
Institute of Technology, Cambridge, MA *CR
2649 — 9:45 Glaucomatous retinal nerve fiber
layer loss is associated with slower reaction
times under a divided attention task. Andrew
J. Tatham1, P. Rosen1, E. R. Boer1, 2, L. M.
Zangwill1, R. N. Weinreb1, D. Meira-Freitas1,
M. Della Penna3, F. A. Medeiros1. 1Hamilton
Glaucoma Center, University of California San
Diego, La Jolla, CA; 2Department of Mechanical
Engineering, Delft University of Technology, Delft,
Netherlands; 3Entropy Control, Inc., La Jolla,
CA *CR, f
2650 — 10:00 Incorporating 10-2 visual
field data for estimating retinal ganglion cell
counts in glaucoma. Ivan M. Tavares1, 2, A. J.
Tatham2, L. M. Zangwill2, R. N. Weinreb2, F. A.
Medeiros2. 1Ophthalmology, Federal University
of Sao Paulo, Sao Paulo, Brazil; 2Ophthalmology,
UCSD Hamilton Glaucoma Center, La Jolla,
CA *CR, f
2643 — 10:00 The influence of dopamine on
contrast sensitivity in physiologically defined
retinal ganglion cells. Michael L. Risner, D.
Sprinzen, D. McMahon. Biological Sciences,
Vanderbilt University, Nashville, TN
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
199
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2638 — 8:45 AAV-Mediated Expression
Targeting of Retinal Rod Bipolar Cells with An
Optimized mGluR6 Promoter. Zhuo-Hua Pan1, 2,
Q. Lu2, T. Ganjawala2, J. Cheng3.1Ophthalmology,
Wayne State Univ Sch of Med, Detroit,
MI; 2Anatomy & Cell Biology, Wayne State
University, Detroit, MI; 3Neuroscience Center,
University of North Carolina, Chapel Hill, NC *CR
2647 — 9:15 Accommodative Movements
of the Choroid in the Region of the Optic
nerve in Young and Old Eyes. MaryAnn
Croft1, J. A. Kiland1, G. A. Heatley1, T. Nork1, J.
McDonald1, A. Katz1, E. Lutjen-Drecoll2, P. L.
Kaufman1, 3. 1Ophthalmology, Univ of WisconsinMadison, Madison, WI; 2Anatomy II, University
of Erlangen-Nuremberg, Erlangen, Germany;
3
Wisconsin National Primate Research Center,
National Primate Research Center, University of
Wisconsin-Madison, Madison, WI *CR
2651 – 2671 – Tuesday – Papers/Minisymposium
S 230EF
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics /
Biochemistry/Molecular Biology / Physiology/
Pharmacology / Visual Neuroscience
303 New Perspectives on Color Vision Minisymposium
This session provides a comprehensive overview
of recent advances in the understanding of human
color vision. Color vision will be approached from
different viewpoints. The objective of the session is
to give an overview of the current techniques, data
and ideas on cone signal processing as the basis of
color vision.
Moderators: Jan Kremers and Rigmor Baraas
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2651 — 8:30 Introduction to new perspectives
on color vision. Rigmor Baraas. Optometry &
Visual Science, Buskerud University College,
Norway, Kongsberg, Norway
2652 — 8:35 New Perspectives on the Genetics
of Color Vision. Maureen Neitz. Ophthalmology,
University of Washington, Seattle, WA
2653 — 8:55 Noninvasive Electrophysiology
of Cone Opponent processes in the Human
Retina. Jan Kremers. Dept of Ophthalmology,
University Hospital Erlangen, Erlangen, Germany
2654 — 9:15 Cone-by-cone assessment of
visual function in vivo. Lawrence Sincich.
Sch of Optometry, The University of Alabama,
Birmingham, AL
2655 — 9:35 The retinal circuitry of
cone-opponent processing. EJ Chichilnisky.
Neurosurgery, Stanford University, Stanford, CA
2656 — 9:55 Integrating color with
non-chromatic features. Steven K.
Shevell. 1Psychology and Ophthalmology &
Visual Science, University of Chicago, Chicago,
IL; 2Institute for Mind and Biology, University of
Chicago, Chicago, IL
2658 — 8:45 Visualisation of two dimensional
null regions in Infantile Nystagmus for
functional and clinical use. Vijay Patel, F. A.
Proudlock, I. Gottlob. Ophthalmology Group,
University of Leicester, Leicester, United Kingdom
2659 — 9:00 Visual field deficits in
albinism. Viral Sheth, I. Gottlob, S. Mohammad, R.
J. McLean, F. A. Proudlock. Ophthalmology, The
University Of Leicester, Leicester, United Kingdom
2660 — 9:15 Magnetic Resonance Imaging
(MRI) of Differential Compartmental Function
of Extraocular Muscles (EOMs) During Vertical
Fusional Vergence. Joseph L. Demer1, 2, R. A.
Clark1. 1Ophthalmology, Jules Stein Eye Inst,
UCLA, Los Angeles, CA; 2Neurology, UCLA, Los
Angeles, CA
2661 — 9:30 Functional Activity Significantly
Correlates to Symmetrical Vergence Peak
Velocity: An fMRI study of Vision Therapy. Tara
Alvarez, R. Jaswal, S. Gohel, B. B. Biswal.
Biomedical Engineering, New Jersey Institute of
Technology, Newark, NJ
2662 — 9:45 Persistence of oculomotor
training effects in mild traumatic brain
injury (mTBI). Preethi Thiagarajan1, 2, K. J.
Ciuffreda2. 1Retina Foundation of the Southwest,
Dallas, TX; 2State College of Optometry, State
University of New York, New York, NY
2663 — 10:00 The Infant Aphakia Treatment
Study (IATS): Fixational Instabilities Following
Extraction of Unilateral Infantile Cataract. Joost
Felius1, 2, C. Busettini3, S. R. Lambert4, M. J.
Lynn5, E. Hartmann3. 1Retina Foundation of the
Southwest, Dallas, TX; 2Ophthalmology, University
of Texas Southwestern Medical Center, Dallas,
TX; 3Vision Sciences, University of Alabama at
Birmingham, Birmingham, AL; 4Ophthalmology,
Emory University, Atlanta, AL; 5Biostatistics and
Bioinformatics, Emory University, Atlanta, AL f
S 310A-D
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Glaucoma
305 Neuroprotection
S 230GH
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology / Clinical/Epidemiologic
Research
304 Eye movements
Moderators: Avery H. Weiss and Joseph L. Demer
2657 — 8:30 Crouzon Syndrome: Relationship
of Eye Movements to Pattern Strabismus. Avery
H. Weiss1, 2, J. O. Phillips1, 3. 1Ophthal, Roger
Johnson Vis Lab, Seattle Children’s Hosp/W-7729,
Seattle, WA; 2Ophthalmology, University of
Washington, Seattle, WA; 3Otolaryngology,
University of Washington, Seattle, WA
Moderators: Ian Trounce, Nicholas MarshArmstrong and Franz H. Grus
2664 — 8:30 Acid sphingomyelinase activation
suppresses the ischemia-induced production of
TNF-α in the retina. Jie Fan, O. Alsarraf, C. E.
Crosson. Ophthalmology-Storm Eye Inst, Medical
Univ of South Carolina, Charleston, SC *CR
2665 — 8:45 The phosphodiesterase inhibitor
Ibudilast attenuates glial cell reactivity,
production of proinflammatory cytokines
and neuronal loss in experimental glaucoma.
Nicolas Belforte, J. L. Cueva-Vargas, A. Di
Polo. Department of Neuroscience, University of
Montreal Hospital Research Center, Montreal, QC,
Canada
2666 — 9:00 The effect of IOP reduction in
a rat model of chronic ocular hypertension
induced by a circumlimbal suture. Hsin-Hua
Liu1, Z. He1, J. M. Kezic2, C. T. Nguyen1, A.
J. Vingrys1, B. V. Bui1. 1Optometry & Vision
Sciences, University of Melbourne, Parkville, VIC,
Australia; 2Anatomy & Developmental Biology,
Monash University, Clayton, VIC, Australia
2667 — 9:15 Knockout Of Caspase-7 Protects
Against Optic Nerve Crush-Induced Retinal
Ganglion Cell Death. Shreyasi Choudhury1, 2,
Y. Liu1, A. F. Clark1, I. Pang1, 2. 1North Texas Eye
Research Institute, Cell Biology and Immunology,
University of North Texas Health Science Center,
Fort Worth, TX; 2Department of Pharmaceutical
Sciences, University of North Texas Health Science
Center, Fort Worth, TX *CR
2668 — 9:30 Long Term Resveratrol Treatment
Provides Differential Protection of Injured
Retinal Ganglion Cell Dendrites. James D.
Lindsey1, K. X. Duong-Polk1, D. Hammond1, C.
K. Leung2, R. N. Weinreb1. 1Hamilton Glaucoma
Center, University of California San Diego, La
Jolla, CA; 2University Eye Center, Hong Kong Eye
Center, Hong Kong, Hong Kong
2669 — 9:45 Neuritin1 Promotes Retinal
Ganglion Cell Survival And Axonal Regeneration
Following Optic Nerve Crush. Tasneem P.
Sharma1, 2, Y. Liu1, 2, I. Pang3, 2, R. J. Wordinger1, 2,
A. F. Clark1, 2. 1CBI - Visual Sciences, University
of North Texas Health Science Center, Fort Worth,
TX; 2NTERI, University of North Texas Health
Science Center, Fort worth, TX; 3Pharmaceutical
Sciences, University of North Texas Health Science
Center, Fort worth, TX *CR
2670 — 10:00 The role of focal adhesion kinase
(FAK) in retinal ganglion cells regeneration. M
Livia Bajenaru1, B. Albo Obeso1, X. Luo2, A.
C. Santos1, O. Khoury1, E. Trakhtenberg1, W.
Dietrich2, J. L. Goldberg3, K. Park2. 1Miller School
of Medicine, Univ of Miami, Bascom Palmer Eye
Inst, Miami, FL; 2Miller School of Medicine, Miami
Project to Cure Paralysis, Miami, FL; 3Shiley Eye
Institute, University of California San Diego, San
Diego, CA
S 310E-H
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Retinal Cell Biology
306 Stem Cells: Biology and
Therapeutic Applications
Moderators: David M. Gamm and
Andrea S. Viczian
2671 — 8:30 Differentiation of Human Stem
Cells to Retinal Ganglion-like Cells using a
CRISPR/Cas9 Engineered Reporter Line. Donald
J. Zack, V. Sluch, V. Ranganathan, C. Berlinicke.
Ophthalmology, Wilmer Eye Inst, Johns Hopkins
Univ, Baltimore, MD
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices.
200
2672 — 8:45 A High Throughput Screen
for small molecules that promote stem
cell differentiation into Retinal Pigmented
Epithelium. Julien Maruotti1, J. Fuller1, K. Wahlin1,
V. Sluch1, C. Kim1, J. Wan1, K. Bharti2, J. Davis2,
S. S. Miller2, D. J. Zack1. 1Ophthalmology, Johns
Hopkins University, Baltimore, MD; 2National Eye
Institute, Bethesda, MD
2673 — 9:00 Induced Pluripotent Stem
Cell-derived Tissues Elicit Selective
Immunogenicity. Daniel Feitelberg1, P. D.
Westenskow1, S. Bravo1, T. Zhao2, Z. Rong2, C.
M. Wittgrove1, L. P. Paris1, D. O. Clegg3, Y. Xu2,
M. Friedlander1. 1Cell and Molecular Biology, The
Scripps Research Institute, La Jolla, CA; 2Molecular
Biology, University of California, San Diego, La
Jolla, CA; 3Molecular, Cell and Developmental
Biology, University of California, Santa Barbara,
Santa Barbara, CA
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
307 Life-and-death consequences of
visual impairment
Moderators: Pradeep Y. Ramulu and
Jeffrey R. Willis
2678 — 8:30 Regional Variations in Reported
Eye Care and Disease Prevalence: Analysis of
the 2010 BRFSS Database. Ilyse Kornblau1, K.
Pierson2, Y. Kuo2, B. F. Godley1.1Ophthalmology
and Visual Sciences, UTMB, Galveston,
TX; 2Epidemiology, UTMB, Galveston, TX
2679 — 8:45 Prevalence of Poor Vision
among Individuals Hospitalized in the
United States. Jeffrey R. Willis1, P. Y.
Ramulu2. 1Ophthalmology, University of CaliforniaDavis, Sacramento, CA; 2Ophthalmology, Johns
Hopkins University, Baltimore, MD
2680 — 9:00 Utilization of home care
services by Canadian elderly with and without
uncorrectable vision loss. Lina Chen1, G. E.
Trope1, 2, Y. M. Buys1, 2, Y. Jin1, 3. 1University of
Toronto, Toronto, ON, Canada; 2University Health
Network, Toronto, ON, Canada; 3Dalla Lana School
of Public Health, Toronto, ON, Canada
2675 — 9:30 Using patient-derived iPSCs to
identify new drug treatments for JNCL. Luke A.
Wiley1, K. Anfinson1, E. E. Kaalberg1, S. Shrestha1,
S. Swaminathan1, A. V. Drack1, R. Mullins1, E. M.
Stone1, 2, B. A. Tucker1. 1Stephen A. Wynn Institute
for Vision Research, Department of Opthalmology
& Visual Sciences, University of Iowa, Iowa City,
IA; 2Howard Hughes Medical Institute, Department
of Ophthalmology & Visual Sciences, University of
Iowa, Iowa City, IA
2681 — 9:15 Driving visual fields and
retrospective at-fault motor vehicle collision
involvement in older drivers: a population-based
study. Carrie E. Huisingh1, G. McGwin1, J. M.
Wood2, C. Owsley1. 1Department of Opthalmology,
609 Callahan Eye Hospital, Birmingham,
AL; 2School of Optometry and Vision Sciences
and Institute of Health and Biomedical Innovation,
Queensland University of Technology, Kelvin
Grove, QLD, Australia
2676 — 9:45 Gene Therapy for MAKassociated RP. Edwin M. Stone1, 2, A. V. Drack1,
R. M. Johnston1, H. T. Daggett1, J. M. Hoffmann1,
C. M. Hass1, J. A. Penticoff1, M. M. Collins1, R.
Mullins1, B. A. Tucker1. 1Stephen A Wynn Institute
for Vision Research, Department of Ophthalmology
and Visual Sciences, University of Iowa, Iowa City,
IA; 2Howard Hughes Medical Institute, Department
of Ophthalmology and Visual Sciences, University
of Iowa, Iowa City, IA
2682 — 9:30 Visual impairment, age-related
eye diseases and mortality: the Singapore Malay
Eye Study (SiMES). Rosalynn G. Siantar1, T.
Y. Wong1, 2, P. Ong1, K. Y. Chow3, C. Cheng1, 2,
P. Mitchell4, C. Y. Cheung1, 2. 1Singapore Eye
Research Institute, Singapore National Eye Centre,
Singapore, Singapore; 2Ophthalmology, Yong
Loo Lin School of Medicine, National University
of Singapore, Singapore, Singapore; 3National
Registry of Diseases Office, Ministry of Health,
Singapore, Singapore; 4Centre for Vision Research,
University of Sydney, Sydney, NSW, Australia
2677 — 10:00 Targeting protein degradation
pathways in macular degeneration using a
human iPS cell model of Best disease. Ruchira
Singh1, 3, D. Kuai1, J. Meyer1, M. Smith1, K.
Wallace1, A. Verhoeven1, D. M. Gamm2, 3. 1Waisman
Center, University of Wisconsin, Madison,
WI; 2Dept. of Ophthalmology and Visual Sciences,
University of Wisconsin, Madison, WI;3McPherson
Eye Research Institute, University of Wisconsin,
Madison, WI
2683 — 9:45 Visual Acuity and Increased
Mortality: The Role of Allostatic Load and
Functional Status. Dandan D. Zheng1, S. L.
Christ3, B. L. Lam2, S. Tannenbaum1, D. J.
Lee1.1Epidemiology & Public Health, University of
Miami, Miami, FL; 2Bascom Palmer Eye Institute,
University of Miami, Miami, FL; 3Department of
Human Development and Family Studies, Purdue
University, West Lafayette, IN
2684 — 10:00 Glaucoma-Associated Longterm Mortality in a Rural Cohort from India:
The Andhra Pradesh Eye Disease Study. Rohit
C. Khanna1, 2, M. Gudlavalleti3, 4, P. Giridhar1, 2,
S. Marmamula1, 2, H. B. Pant4, G. Shantha5, 6, S.
Chakrabarti2, C. Gilbert3, G. N. Rao1, 2. 1Allen
Foster Research Centre for Community Eye
Health, International Centre for Advancement
of Rural Eye care, L V Prasad Eye Institute,
Hyderabad, India; 2Brien Holden Eye Research
Centre, L V Prasad Eye Institute, Hyderabad,
India; 3International Centre for Eye Health,
Department of Clinical Research, London School
of Hygiene and Tropical Medicine, London, United
Kingdom; 4Indian Institute of Public Health,
Hyderabad, India; 5Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD;
6
Department of Internal Medicine, Wright Center
for Graduate Medical Education, Scranton, PA
S 320GH
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Biochemistry/Molecular Biology
308 Mechanisms in Retinal
degeneration
Moderators: Kenneth P. Mitton and Jan Wijnholds
2685 — 8:30 Structural and Functional
Changes in the ABCA4 Transporter
Associated with Mutations that Cause Retinal
Degeneration. Yaroslav Tsybovsky, K. Palczewski.
Pharmacology, Case Western Reserve University,
Cleveland, OH
2686 — 8:45 CRB proteins expression and
localization in human retina. Lucie Pellissier1, J.
Klooster2, J. Wijnholds1. 1Neuromedical Genetics,
NIN, Amsterdam, Netherlands;2Retinal Signal
Processing, NIN, Amsterdam, Netherlands
2687 — 9:00 The Progressive Rod-Cone
Degeneration (PRCD) Protein is Secreted
Through the Conventional ER/Golgi-Dependent
Pathway. Tamar Ben-Yosef1, L. Remez1, D.
Zobor2, S. Kohl2. 1Genetics Dept - Faculty of Med,
Technion, Haifa, Israel; 2Institute for Ophthalmic
Research, University Clinics Tuebingen, Tuebingen,
Germany
2688 — 9:15 Mechanisms of axonal
regeneration in postnatal and adult monkey
retinal gangli-on cells. Solon Thanos1, 2, S.
Mertsch1, 2, K. Schlich1, 2. 1Institute of Experimental
Ophthalmology, University of Münster, Münster,
Germany; 2Center of Excellence Cells in Motion
(CiM), University of Münster, Münster, Germany
2689 — 9:30 Annexin-V Imaging of
Degenerating Axons Following Experimental
Anterior Ischemic Optic Neuropathy. Gun
Ho Lee, M. Shariati, J. Ma, Y. J. Liao. Stanford
University, Palo Alto, CA
201
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2674 — 9:15 Safety outcome of subretinal
human embryonic stem cell-derived pigment
epithelium (hESC-RPE) transplantation in
Yucatan mini-pigs with oral or intravenous
immunosupression. Paulo Falabella1, 2, M. J.
Koss1, F. R. Stefanini1, M. Pfister1, G. J. Chader2,
B. B. Thomas2, P. Thomas1, D. O. Clegg3, D. R.
Hinton2, M. S. Humayun2. 1Doheny Eye Institute,
Los Angeles, CA; 2Department of Ophthalmology
- Keck School of Medicine, University of Southern
California, Los Angeles, CA; 3University of
California, Santa Barbara, Santa Barbara, CA
S 320CD
2690 — 9:45 In Vivo Model of the Molecular,
Functional, and Morphological Changes
Occurring During Blood Retinal Barrier
Disruption by VEGF. Kenneth P. Mitton1,
R. Schunemann1, E. Guzman1, W. Dailey1, M.
Cheng1, K. A. Drenser1, 2, M. T. Trese1, 2. 1Eye
Research Institute, Oakland University, Rochester,
MI; 2Associated Retinal Consultants, Royal Oak, MI
S 330CD
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Anatomy/Pathology
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
309 New Insights into the Anatomy of
Blood and Lymphatic Vasculature of
the Eye - Minisymposium
This minisymposium highlights the emerging
methods of in-vivo and in-vitro visualization of
blood and lymphatic vasculature of the anterior
and posterior segments of the eye. It also
provides an overview of how these methods have
contributed to improved understanding of disease
pathophysiology, surveillance, and treatment.
Moderators: Ludwig M. Heindl and
Robert J. Zawadzki
— 8:30 Introduction
2691 — 8:32 Immunhistochemical Detection
of Blood and Lymphatic Vessels: Potency
and Limitations of Novel Markers. Falk
Schroedl. 1Ophthalmology, Paracelsus Medical
University, Salzburg, Austria; 2Anatomy, Paracelsus
Medical University, Salzburg, Austria
2692 — 8:47 In Vivo Imaging of Blood Vessels:
Potential and Limitations of OCT-based methods
at the Ocular Surface and Fundus. Robert J.
Zawadzki. Ophthalmology & Vision Science, UC
Davis, Sacramento, CA
2693 — 9:02 Vasculature of the Cornea and
Ocular Surface: New Implications for Corneal
Transplantation and Dry Eye Disease. Claus
Cursiefen. Dept of Ophthalmology, Koln,
Germany *CR
2694 — 9:17 Vasculature of the Conjunctiva:
New Implications for Ocular Tumors. Ludwig M.
Heindl. Department of Ophthalmology, University
of Cologne, Cologne, Germany
2695 — 9:32 Vasculature of the Retina
and Choroid: New Implications for retinal
diseases. Richard F. Spaide. Vitreous Retina Macula
Consultants, New York, NY *CR
2696 — 9:47 In Vivo Imaging of Lymphatics:
Challenges and Opportunities. Yeni H. Yucel.
Ophthal & Vision Sciences, Univ of Toronto/St
Michael Hosp, Toronto, ON, Canada
— 10:02 Concluding remarks /
Panel discussion
S 331A-D
Hall SB
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Cornea
Retina / Physiology/Pharmacology
310 Cornea surgery, non-refractive
311 Novel Approaches for
Retinal Drug and Gene Delivery
- TVST Minisymposium
Moderators: Shiro Amano, Frank Larkin and
Vincent M. Borderie
2697 — 8:30 Factors associated with thickness
of eye bank-prepared DSAEK graft tissue. Grace
M. Wang1, M. A. Woodward1, M. O’Keefe2, I.
Vadakkepattath2, M. Titus3, T. Blachley1, D. C.
Musch1, R. M. Shtein1. 1University of Michigan
Kellogg Eye Center, Ann Arbor, MI; 2Midwest EyeBanks, Ann Arbor, MI; 3Saving Sight, Columbus,
MO *CR
The symposium intends to review recent advances
in retinal drug and gene delivery with specific
emphasis on novel approaches that address current
limitations and can translate into clinical practice.
This minisymposium is sponsored by Translational
Vision Science and Technology, an ARVO
journal. TVST will publish a paper on this session
later in 2014.
2698 — 8:45 Comparison of Gebauer SLc and
Moria CBm ALK Microkeratomes for DSAEK
lamella preparation and storage. Matthias Fuest,
A. Flammersfeld, S. Salla, P. Walter, M. Hermel.
Ophthalmology, RWTH Aachen University, Aachen,
Germany
Moderators: Stephen Kim and
Jennifer J. Kang Mieler
2699 — 9:00 Pre-Descemetic Automated
Endothelial Keratoplasty (PDAEK), towards an
automated DMEK preparation technique. Mor
Dickman1, J. Brekelmans1, P. Steijger-Vermaat2, T.
Wesseling2, F. van Marion2, F. Van den Biggelaar1,
T. Berendschot1, R. M. Nuijts1. 1University
Eye Clinic Maastricht, Maastricht University
Medical Center, Maastricht, Netherlands; 2Euro
Cornea Bank, Euro Tissue Bank, Beverwijk,
Netherlands *CR
2700 — 9:15 Preparation of large grafts for
Endothelial Keratoplasty. Vito Romano, A.
Tey, N. Hill, J. Chen, C. Britten, S. Ahmad, M.
Batterbury, C. E. Willoughby, S. Kaye. Royal
Liverpool University Hospital, University of
Liverpool, Liverpool, United Kingdom
2701 — 9:30 Comparison of corneal endothelial
change post DSAEK using paired grafts from the
same donor to two recipients. Tsutomu Inatomi,
H. Nakagawa, K. Miyamoto, C. Sotozono, S.
Kinoshita. Ophthalmology, Kyoto Prefectural Univ
of Med, Kamigyo-Ku, Japan
2702 — 9:45 Relationship between
Hyperopic Shift after DSAEK and Corneal
Anterior Curvature, Posterior Curvature, and
Thickness. William B. Wainright1, R. McNabb1,
A. Carlson1, T. Kim1, N. A. Afshari2, A. N.
Kuo1. 1Ophthalmology, Duke University, Durham,
NC; 2Ophthalmology, University of California, San
Diego, San Diego, CA *CR
2704 — 8:30 Nanotechnology for Drug and
Gene Delivery to the Eye. Uday Kompella.
Pharmaceutical Sciences & Ophthalmology, UC
Denver, Aurora, CO
2705 — 8:45 Safety, pharmacokinetics, and
efficacy of intraocular NSAIDs for retinal
disease. Stephen Kim. Ophthalmology, Vanderbilt
University, Nashville, TN
2706 — 9:00 Hydrogel and nanoparticles for
posterior drug delivery. Jennifer J. Kang Mieler.
Biomedical Engineering, Illinois Institute of
Technology, Chicago, IL *CR
2707 — 9:15 Phase I clinical study of a thirdgeneration simian immunodeficiency virus
(SIV)-based lentiviral vector carrying human
pigment epithelium-derived factor (hPEDF) gene
for patients with retinitis pigmentosa. Yasuhiro
Ikeda. Dept of Ophthalmology, Kyushu University,
Fukuoka, Japan f
2708 — 9:30 AAV vector gene delivery for
treatment of retinal disease. Shannon Boye.
Ophthalmology, University of Florida, Gainesville,
FL
2709 — 9:45 Suprachoroidal drug
delivery. Timothy Olsen. Dept of Ophthalmology,
Emory, Atlanta, GA
2710 — 10:00 Topical drug delivery for retinal
disease. Baruch Kupperman. Gavin Herbert Eye
Inst Dept Ophthal, University of California, Irvine,
Irvine, CA *CR
2703 — 10:00 Quality of Life Before and
After Keratoplasty for Fuchs Endothelial
Dystrophy. Eleanor Trousdale1, D. Hodge2, K.
H. Baratz1, L. J. Maguire1, W. M. Bourne1, S. V.
Patel1. 1Ophthalmology, Mayo Clinic, Rochester,
MN; 2Biomedical Statistics and Informatics, Mayo
Clinic, Jacksonville, FL *CR, f
202
Tuesday – Posters – 2711 – 2732
Exhibit/Poster Hall SA A0093-A0117
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
312 Refractive Error
Moderator: Christine Wildsoet
2711 — A0093 SPARCS: A novel assessment
of contrast sensitivity and its validity in patients
with refractive error. Yi Sun2, 1, E. Erdem1, A.
Lyu1, C. Zangalli1, S. S. Wizov1, D. Lo1, E. Spaeth1,
J. Richman1, G. L. Spaeth1. 1Wills Eye Institution,
Philadelphia, PA; 2Opthalmology, West China
Hospital, Chengdu, China *CR, f
2712 — A0094 Quality of Functional Vision
Through Adjustable Spectacles [FocusSpecs]
Phase II. Ran He, H. Gaiser, N. Solaka, L. Deng, B.
D. Moore. The New England College of Optometry,
Boston, MA
2714 — A0096 Comparing Visual Image
Quality with Objectively and Subjectively
Derived Spectacle Corrections in Subjects with
Keratoconus. Jason D. Marsack1, L. Anderson1, A.
Ravikumar1, H. A. Anderson1, J. J. Rozema2, 3, R.
A. Applegate1. 1Optometry, University of Houston,
Houston, TX; 2Ophthalmology, Antwerp University
Hospital, Edegem, Belgium; 3Faculty of Medicine
and Health Sciencies, University of Antwerp,
Wilrijk, Belgium *CR
2715 — A0097 Refractive Retinoscopy. Clinton
Sims. University of Louisville, Louisville, KY *CR
2716 — A0098 The impact of target type and
verbal instructions on accommodative status
during objective refraction. Barbara M. Junghans,
S. Liu, Y. Yeung, K. Watt, L. Asper. School of
Optometry and Vision Science, Univ of New South
Wales, UNSW Sydney, NSW, Australia
2717 — A0099 Evaluation of a real-time
Hartman-Shack based autorefractor. Florence
Cabot1, 2, V. Hernandez2, 3, F. Manns2, 3, S. H. Yoo1, 2,
A. Ho4, 5, J. A. Parel2, 6. 1Anne Bates Leach Eye
Hospital, Bascom Palmer Eye Institute, University
of Miami Miller School of Medicine, Miami,
FL; 2Ophthalmic Biophysics Center, Bascom
Palmer Eye Institute, University of Miami Miller
School of Medicine, Miami, FL; 3Department
of Biomedical Engineering, University of
Miami College of Engineering, Coral Gables,
FL; 4Brien Holden Vision Institute, Sydney,
NSW, Australia; 5Optometry and Vision Science,
University of New South Wales, Sydney, NSW,
Australia; 6Vision Cooperative Research Centre,
Sydney, NSW, Australia *CR
2719 — A0101 A Comparison of Two
Automated Tests of Refractive Error. James R.
Drover1, 2, D. Mayo3, D. Bautista2, L. Bramwell2,
N. Kielly3, S. Caldwell1, S. Cornick1, M. Davis1,
M. Pollard1. 1Psychology, Memorial University of
Newfoundland, St. John’s, NF, Canada; 2Pediatrics,
Memorial University of Newfoundland, St. John’s,
NF, Canada; 3Optometrist, Private Practice, St.
John, NF, Canada
2720 — A0102 Comparison of two methods for
performing subjective refractions. Shui T. Lai.
Vmax Vision, Maitland, FL *CR
2721 — A0103 Epidemiology of the
predominance of noncorneal ocular regular
astigmatism (ORA) compared to anterior
corneal astigmatism. Jonathan Crews, L. Kugler.
Ophthalmology, UNMC, Omaha, NE
2722 — A0104 Comparison Of A New
Prototype Of Netra-G Cell Phone-Based
Refraction With Subjective Refraction. Nadine
Solaka1, R. Modi2, H. Gaiser1, V. Pamplona2, D.
Schafran2, R. He1, B. D. Moore1. 1New England
College of Optometry, Boston, MA; 2EyeNetra Inc.,
Boston, MA *CR
2723 — A0105 Identification and Comparison
of Critical Axis Combinations for Estimating the
Refractive Power of the Eye using NETRA. Vitor
F. Pamplona2, J. Kartik1, S. Bharadwaj1, P. Nakhate2,
N. Sharpe2. 1L.V.Prasad Eye Institute, Hyderabad,
India; 2EyeNetra Inc, Somerville, MA *CR
2724 — A0106 Racial difference in the
defocus calibration of eccentric infrared
photorefraction. Shrikant Bharadwaj1, 2, V. Kumar1,
G. Sravani1. 1Prof Brien Holden Centre for Eye
Research, L V Prasad Eye Institute, Hyderabad,
India; 2Bausch & Lomb School of Optometry, L V
Prasad Eye Institute, Hyderabad, India
2725 — A0107 Accuracy of the Spot Pediatric
Vision Screener for Detection of Hyperopia,
Astigmatism and Anisometropia. Hilary Gaiser1,
B. D. Moore1, N. Solaka1, D. M. Ledoux2, J.
Sandoval2, A. R. Shah2, C. Rook2, R. He1. 1New
England College of Optometry, Boston,
MA; 2Children’s Hospital, Boston, MA
2726 — A0108 Refraction along the vertical
meridian in different refractive groups. Pauline
Kang, P. Gifford, H. A. Swarbrick. School of
Optometry and Vision Science, The University of
New South Wales, Sydney, NSW, Australia *CR
2727 — A0109 Refractive error and
ocular components among schoolchildren
in Campinas, Brazil. Rodrigo P. Lira1, 2, C.
L. Arieta2, D. Maziero2, T. M. Passos2, G. L.
Astur2,. E. Santo2, A. Bertolani2, L. F. Pozzi2,
R. S. Castro2. 1Ophthalmology, UFPE, Recife,
Brazil; 2Ophthalmology, UNICAMP, Campinas,
Brazil
2728 — A0110 Periphery Retinal Contour in
Children with Myopia of Prematurity. Jingyun
Wang1, C. A. Clark2. 1Department of
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN; 2Indiana University
School of Optometry, Bloomington, IN
2729 — A0111 Can current models of
accommodation and vergence predict
accommodative behavior in myopic children?
William R. Bobier1, V. Sreenivasan2, E. L.
Irving1.1School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 2School of Optometry, Indiana University,
Bloomington, IN
2730 — A0112 Environmental Alteration
of Crystalline Lens Power by Light During
Refractive Development in Chicks. Yuval
Cohen1, 3, R. Iribarren2, A. S. Solomon3, R. A.
Stone1. 1Department of Ophthalmology, University
of Pennsylvania School of Medicine, Philadelphia,
PA; 2Centro Medico San Luis, Buenos Aires,
Argentina; 3Goldschleger Eye Research Institute,
Tel Aviv, Israel
2731 — A0113 Asymmetries in Peripheral
Refraction Change with Emmetropization and
Induced Eye Growth. Alexandra Benavente-Perez,
A. Nour, D. Troilo. Biological Sciences, SUNY
College of Optometry, New York, NY
2732 — A0114 Long-term follow-up after
Artisan phakic intraocular lens implantation
in hyperopia. Gwyneth A. Van Rijn, H. P.
Jongman, J. Wijnen, G. P. Luyten. Ophthalmology,
Leiden University Medical Center, Leiden,
Netherlands *CR
203
Tuesday Posters
8:30 am – 10:15 am
2713 — A0095 A method for patient selfrefraction and on-site eyeglass assembly. Jennie
Weinkle, C. Pole, B. Thomas, J. Schiffman, W. Shi,
R. K. Lee. Bascom Palmer Eye Institute, University
of Miami Miller School of Medicine, Miami, FL
2718 — A0100 Evaluation of a low-cost
wavefront aberrometer for measuring refractive
errors. Eduardo Lage1, F. A. Vera-Diaz2, S. R.
Dave1, D. Lim1, C. Dorronsoro3, S. Marcos2, F.
Thorn2, N. J. Durr1. 1Madrid-MIT M+Vision
Consortium, Massachusetts Institute of Technology,
Cambridge, MA; 2New England College of
Optometry, Boston, MA; 3Instituto de Óptica “Daza
de Valdés”, Consejo Superior de Investigaciones
Científicas, Madrid, Spain *CR
2733 – 2750 – Tuesday – Posters
2733 — A0115 Genome-wide analysis of
newly developed quantitative phenotypes of
astigmatism. Rui Chen1, S. Kim1, H. Huang2, L.
Shen1, J. Wang3. 1Department of Radiology and
Imaging Sciences, Indiana University School
of Medicine, Indianapolis, IN; 2Department of
Computer Science and Engineering, Univnrsity
of Texas at Arlington, Arlington, TX; 3Eugene
and Marilyn Glick Eye Institute, Department of
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN
Tuesday Posters
8:30 am – 10:15 am
2734 — A0116 The Utility of Cycloplegic
Refraction: Differences Between Manifest and
Cycloplegic Refractions in a Large Population.
Julie M. Schallhorn1, 2, C. S. Schallhorn4, S. C.
Schallhorn2, 3. 1F.I. Proctor Foundation, University
of California, San Francisco, San Francisco,
CA; 2Ophthalmology, University of California,
San Francisco, San Francisco, CA;3Optical
Express, Glasgow, United Kingdom; 4University of
California, San Diego, San Diego, CA *CR
2735 — A0117 Improved Refractive Outcomes
of PGY-4 Cataract Surgery after Structure and
Process Changes at a Teaching Program. Bennett
Y. Hong1, A. Torab Parhiz2, N. Mehta2, T. Chou2, S.
Y. Wu3, T. Haque2, A. Abazari2, K. Kaplowitz2, R.
A. Honkanen2, 4. 1The School of Medicine at Stony
Brook University, Stony Brook, NY; 2Department of
Ophthalmology, The School of Medicine at Stony
Brook University, Stony Brook, NY; 3Department
of Preventive Medicine, The School of Medicine
at Stony Brook University, Stony Brook,
NY;4Ophthalmology, SUNY Eye Institute, Stony
Brook, NY
Tuesday, May 06, 2014 8:30 AM-10:15 AM
313 Vision testing in children
Moderator: Angela M. Brown
2736 — A0118 The contrast sensitivity of
the newborn infant. Angela M. Brown1, D. T.
Lindsey1, 2, J. G. Cammenga1, L. Chandler3, S.
Heintzman3, H. Bookless3, P. J. Giannone4, 3.
1
College of Optometry, Ohio State University,
Columbus, OH; 2Department of Psychology,
Ohio State University, Mansfield, OH; 3College
of Medicine, Ohio State University, Columbus,
OH; 4College of Medicine, University of Kentucky,
Lexington, KY *CR
2737 — A0119 An automated test of infant
visual acuity using remote eye-tracking. Pete
R. Jones1, S. Kalwarowsky1, J. Wattam-Bell2, M.
Nardini1, 3. 1Institute of Ophthalmology, UCL,
London, United Kingdom; 2Division of Psychology
and Language Sciences, UCL, London, United
Kingdom; 3Department of Psychology, Durham
University, Durham, United Kingdom
2738 — A0120 Suitability of computer
generated grating acuity stimuli for assessment
of grating acuity in children. Howard P.
Apple1, 3, T. K. Leonard-Green1, E. M. Harvey1, 2,
J. M. Miller1, 2, D. Apple3. 1Ophthalmology and
Vision Science, University of Arizona, Tucson,
AZ; 2College of Public Health, University of
Arizona, Tucson, AZ; 3Apple Medical Incubator,
Inc., Winter Park, FL
2739 — A0121 Inter-observer and Intraobserver Reliability of Measurements of
the Obliquity of Palpebral Fissures. Amy L.
Davis, J. D. Twelker, J. M. Miller, E. M. Harvey.
Ophthalmology and Vision Science, University of
Arizona, Tucson, AZ
2740 — A0122 Meridional amblyopia
in astigmatic students documented with
computer generated stimuli on commercial
displays. Tina K. Leonard-Green1, H. P. Apple1, 2,
D. Apple2, M. Crescioni1, J. M. Miller1, 3, J. D.
Twelker1, 3, A. L. Davis1, I. Campus1, E. M.
Harvey1, 3. 1Ophthalmology and Vision Science,
University of Arizona, Tucson, AZ; 2Apple Medical
Incubator Inc, Winter Park, FL; 3College of Public
Health, University of Arizona, Tucson, AZ
2741 — A0123 Accommodation patterns
in astigmatic children during visual task
performance. Erin M. Harvey1, 2, J. M. Miller1, 2,
H. P. Apple3, P. Parashar4, D. Apple3, J. D.
Twelker1, 2, M. Crescioni1, T. K. Leonard-Green1,
A. L. Davis1. 1Ophthalmology and Vision Science,
University of Arizona, Tucson, AZ; 2College of
Public Health, University of Arizona, Tucson,
AZ; 3Apple Medical Incubator, Winter Park,
FL; 4Internal Medicine, University of Arizona,
Tucson, AZ
2742 — A0124 Direction discrimination of
global motion low contrast patterns in school
aged children. Lotte-Guri Bogfjellmo1, 2, P. J.
Bex3, H. Falkenberg1. 1Optometry and Visual
science, Buskerud and Vestfold University College,
Kongsberg, Norway; 2Optometry and visual
science, Buskerud and Vestfold university college,
Kongsberg, Norway; 3Schepens Eye Research
Institute, Harvard Medical School, Boston, MA
2743 — A0125 Posterior corneal curvature
conforms to anterior cornea curvature in
astigmatic Tohono O’odham Native American
schoolchildren. Joseph M. Miller1, 2, E. M. Harvey1,
J. D. Twelker1, M. W. Belin1, D. Sherrill3. 1Ophthal
& Vision Science, University of Arizona, Tucson,
AZ; 2Optical Sciences, University of Arizoan,
Tucson, AZ; 3Public Health, University of Arizona,
Tucson, AZ *CR
2744 — A0126 Native American schoolchildren
tend to emmetropize to the spherical equivalent,
regardless of level of astigmatism. John D.
Twelker1, 2, J. M. Miller1, 2, E. M. Harvey1. 1Ophthal
& Vision Science, University of Arizona, Tucson,
AZ; 2Public Health, University of Arizona, Tucson,
AZ
2745 — A0127 Objective near heterophoria in
emmetropic and hyperopic preschool children.
Vidhyapriya Sreenivasan1, E. Ciner2, W. Harbison2,
B. Alva1, M. T. Kulp3, T. Candy1.1Optometry,
Indiana University, Bloomington, IN; 2Pennsylvania
College of Optometry, The Eye Institute, Salus
University, Elkins Park, PA; 3Optometry, The Ohio
State University, Columbus, OH
2746 — A0128 A comparison of foveal
structure and function between the amblyopic
eye and normal fellow eye in children. Na Liao,
C. Li, Y. Li, H. Chen, Q. Wang. wenzhou medical
university, Wenzhou, China
2747 — A0129 Visual Performance and
the use of Coloured Filters in Deaf children.
Peter M. Allen1, 2, R. Hollingsworth1, 2, A.
Ludlow4, R. Calver1, A. Wilkins3. 1Vision and
Hearing Sciences, Anglia Ruskin University,
Cambridge, United Kingdom; 2Vision and Eye
Research Unit, Postgraduate Medical Institute,
Anglia Ruskin University, Cambridge, United
Kingdom; 3Pyschology, Essex University,
Colchester, United Kingdom; 4Pyschology,
University of Birmingham, Birmingham, United
Kingdom *CR
2748 — A0130 Recognition of Global and
Local Aspects of Objects by School Children
with Visual Impairment. Arieh S. Solomon1, L.
Rahmani1, 2. 1Goldschleger Eye Research, Tel-Aviv
University, Tel-Hashomer, Israel; 2Levenstein
Rehabilitation Center, Ranana, Israel
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Cornea
314 Conjunctiva biology and disease,
Ocular surface health and disease 2
Moderator: Saaeha Rauz
2749 — A0131 Polymorphism -1486T/C
TLR 9 gene as a risk factor in infectious
blepharitis. Daniela Garcia Romero1, A. Babayan1,
O. Fernandez1, K. Tellez-Alcaide2, A. RoblesContreras2, H. J. Perez-Cano2. 1Cornea, Hospital de
la luz, Mexico, Mexico; 2Centro de Investigación
Biomédica, Hospital de la luz, Mexico, Mexico
2750 — A0132 Applicability of detecting auto
fluorescence as early sign of pinguecula. Naoko
Shibata1, K. Sasaki2, N. Yamanaka3, N. Hatsusaka1,
H. Sasaki1, 2. 1Ophthalmology, Kanazawa Medical
University, Kanazawa, Japan; 2Division of
Environmental Vision Research, Institute of General
Medical Research, Kanazawa Medical University,
Kanazawa, Japan;3Pathology, Tokyo Research
Institute of Nephrology, Tokyo, Japan
204
2751 — A0133 Prevalence of Allergic
Conjunctivitis, Ocular Surface Disease Subtypes,
and Mixed Disease. Dominick L. Opitz1, J. T.
Kwan2, J. Harthan1, E. Baas1, M. M. Hom3.1Illinois
College of Optometry, Chicago, IL; 2Southern
California College of Optometry at Marshall
B. Ketchum University, Fullerton, CA; 3Private
Practice, Azusa, CA *CR
2752 — A0134 Presence of Human Papilloma
Virus in pterygium and its association with
an apoptotic proteome profile. Victor M.
Bautista1, L. Sámano-Hernández1, 2, H. GonzálezMárquez2, M. Ortiz-Casas1, H. Mejia-Lopez1, Y.
Garfias3, 4. 1Microbiology and Ocular Proteomics,
Inst de Ophthal Conde de Valenciana, Mexico,
Mexico; 2Ciencias de la Salud, Universidad
Autónoma Metropolitana-Iztapalapa, Mexico,
Mexico; 3Bioquímica, Facultad de Medicina,
UNAM, Mexico, Mexico; 4Biología Celular y
Tisular, Instituto de Oftalmología “Conde de
Valenciana”, Mexico, Mexico
2754 — A0136 Outcomes of Pterygium
Extended Removal Followed by Extended
Conjunctival Transplant (P.E.R.F.E.C.T. for
Pterygium®) in a U.S. Southwest population.
Dhyana Velasco, J. M. Roman, L. Rose. University
of New Mexico School of Medicine, Albuquerque,
NM
2755 — A0137 Ocular surface epithelial wound
healing after pterygium excision. Hongshan Liu.
Ophthalmology, Zhongshan Ophthalmic Ctr Hainan
Eye Hosp, Haikou, China
2756 — A0138 Safety and effectiveness of
Biodegradable Implant with Conjunctival flap
surgery for Calcified Scleromalacia. Sangchul
Yoon1, J. Ahn2, K. Seo1. 1Department of
Ophthalmology, Yonsei University, Severance
Hospital, Seoul, Republic of Korea; 2Department
of Ophthalmology, Siloam Eye Hospital, Seoul,
Republic of Korea f
2757 — A0139 The effect of sirolimus and
tacrolimus for modification of conjunctival
wound healing response. Sam Young Yoon1,
H. Tchah2, M. Kim2, J. Kim2. 1Department
of Ophthalmology, Kangdong Sacred Heart
Hospital, Seoul, Republic of Korea; 2Department
of Ophthalmology, Asan Medical Center, Seoul,
Republic of Korea *CR
2758 — A0140 Correlation between acute
conjunctivitis and yellow dust on ocular surface.
Ryota Koh, H. Hayashi, E. Uchio. Ophthalmology,
Fukuoka University, Fukuoka, Japan
2760 — A0142 Conjunctival Goblet Cells
Produce MUC16. Ilene K. Gipson, S. SpurrMichaud, A. Tisdale, C. Marko. Harvard Med Sch/
Dept Ophthal, Schepens Eye Research Inst/MEEI,
Boston, MA
2761 — A0143 TNF-α Inhibits NHE8
Expression in Conjunctival Epithelial Cells.
Mingwu Wang1, Y. Zhao2, J. Li2, F. Ghishan2, H.
Xu2. 1Dept of Ophthalmology, Univ of Arizona
College of Med, Tucson, AZ; 2Pediatrics, Univ of
Arizona College of Med, Tucson, AZ
2762 — A0144 IL-13 Promotes Mucous
Production in Cultured Palpebral Conjunctival
Goblet Cells. Johanna Tukler Henriksson, T. G.
Coursey, S. C. Pflugfelder. Ocular Surface Center,
Cullen Eye Institute, Department of Ophthalmology,
Baylor College of Medicine, Houston, TX
2763 — A0145 Optimization of a protein
extraction method compatible with proteomic
approaches using new device for conjunctival
impression. Pierre Roy1, J. Soria2, J. Etxebarria3,
T. M. Suarez-Cortes2. 1OPIA Technologies SAS,
Paris, France; 2Bioftalmik Applied Research, Derio,
Spain; 3Department of Ophthalmology, Cruces
Hospital, Baracaldo, Spain*CR
2764 — A0146 Hyperosmolar Stress
Downregulates NHE8 Expression in Human
Conjunctival Epithelial Cells. William
Stevenson1, Y. Zhao1, J. Li2, F. Gishan2, H. Xu2, M.
Wang1. 1Department of Ophthalmology and Vision
Science, University of Arizona Medical Center,
Tucson, AZ; 2Department of Pediatrics, University
of Arizona Medical Center, Tucson, AZ
2765 — A0147 The use of Platelet Rich
Fibrin Membrane in Rabbit Conjunctival
Tissue Damage. Mehmet E. Can1, H. B.
Cakmak1, Y. Toklu1, G. Dereli Can1, H.
Unverdi2, S. Hucemenoglu2, G. Güler3, S. C.
Irkkan4. 1Ophthalmology, Yildirim Beyazit
University Ankara Ataturk Training and Research
Hospital, Ankara, Turkey; 2Pathology, Ankara
Training And Research Hospital, Ankara,
Turkey; 3Pathology, Hacettepe University Faculty
of Medicine, Ankara, Turkey; 4Pathology, Dr
Abdurrahman Yurtaslan Ankara Oncology Training
and Research Hospital, Ankara, Turkey
2766 — A0148 Ex Vivo Expansion of Human
Oral Mucosal Epithelial Cells: Serum Selection
Is a Determinant Factor for Cell Proliferation,
Differentiation and Gene Expression. Camilla
Gram1, 2, D. Krohn-Hansen11, 2, E. Gulliksen1, 2,
M. Moe1, 2, L. K. Drolsum1, 2, B. Nicolaissen1, 2,
A. Shahdadfar1, 2. 1Department of Ophthalmology,
Center for Eye Research, Oslo, Norway; 2Oslo
University Hospital, Oslo, Norway
2767 — A0149 Sentinel Lymph Node Biopsy for
Ocular Adnexal Melanomas. Mary Champion1, J.
Neis2, Y. Schnayder2, J. Sokol1. 1Oculofacial Plastic
and Orbital Surgery, University of Kansas, Prairie
Village, KS; 2Otolaryngology, University of Kansas,
Kansas City, KS
2768 — A0150 Lipoxin A4 Inhibits Histaminestimulated Increase in [Ca2+], ERK Activation,
and Mucin Secretion in Cultured Rat
Conjunctival Goblet Cells. Robin R. Hodges1, 2,
D. Li1, 2, J. A. Bair1, 2, M. A. Shatos1, 2, N. Chiang3, 4,
C. N. Serhan3, 4, D. Dartt1, 2. 1Schepens Eye
Research Institute, Boston, MA; 2Ophthalomolgy,
Harvard Medical School, Boston, MA; 3CET&RI,
Brigham and Womens Hospital, Boston, MA;
4
Anesthesiology, Perioperative and Pain Medicine,
Harvard Medical School, Boston, MA *CR
2769 — A0151 Oxidative Stress Measures
and Correlations with Lipid and DNA Damage
Assays for Human Tears and Conjunctival
Cells. Kristina M. Haworth, H. L. Chandler. College
of Optometry, Ohio State University, Columbus,
OH
2770 — A0152 Expression of Housekeeping
gene, Hypoxanthine Phosphoribosyltransferase-1
(HPRT-1) in Conjunctival Epithelial Cells
Under Various Storage Conditions.Rosa M.
Corrales1, 2, R. Patel1, 2, W. Stringer1, 2, J. Brace1, 2, B.
Butler1, 2. 1Ocular Surface Diagnostic Innovations,
LLC, Tampa, FL; 2Point Guard Partners LLC,
Tampa, FL *CR
2771 — A0153 Qualitative and quantitative
analysis of the eyelid and conjunctiva
microbiota: importance of the lid hygiene before
ocular surgery. Asuncion Peral1, C. Niño-Rueda1, P.
Calvo del Bosque1, C. Garcia-Garcia2. 1Optometry
& Vision, Faculty of Optics and Optometry UCM,
Madrid, Spain; 2Microbiology II, Faculty of Optics
and Optometry UCM, Madrid, Spain
2772 — A0154 Conjunctival microbial
flora in Stevens-Johnson syndrome ocular
sequelae patients at a tertiary eye care centre in
India. Renu Venugopal1, S. Sangwan2, G. Satpathy3,
T. Agarwal1, N. Sharma1. 1Ophthalmology, All
India Institute of Medical Sciences, New Delhi,
India; 2Anatomy, All India Institute of Medical
Sciences, New Delhi, India; 3Ocular Microbiology,
Dr. R. P. Centre for Ophthalmic Sciences, All India
Institute of Medical Sciences, New Delhi, India
205
Tuesday Posters
8:30 am – 10:15 am
2753 — A0135 Epidemiological profile and
comparison between refraction before and after
the pterygium surgery. Adriana R. Almeida, C.
M. Nardelli Silva, T. S. Guimarães, L. Stival, J. J.
Nassaralla. Instituto de Olhos de Goiânia, Goiânia,
Brazil f
2759 — A0141 Human goblet cell function in
an in vitro allergic microenvironment. Laura
Garcia-Posadas1, D. Li2, 3, R. R. Hodges2, 3, M.
A. Shatos2, 3, Y. Diebold1, D. Dartt2, 3.1Ocular
Surface Group, IOBA-University of Valladolid,
Valladolid, Spain; 2Schepens Eye Research
Institute/Massachusetts Eye and Ear, Harvard
Medical School, Boston, MA; 3Department of
Ophthalmology, Harvard Medical School,
Boston, MA
2773 — A0155 Pre-Clinical and Clinical
Inflammation of Ocular Adnexa in Graftversus-Host Disease. Samantha Herretes1, J.
C. Murillo1, S. Duffort1, C. Betancurt1, Z. AlMohtaseb1, T. Ali1, D. Waren1, H. Barreras2, R.
Levy1, 2, V. L. Perez1, 2. 1Ophthalmology, Bascom
School of Medicine, Miami, FL;2Immunology and
Microbiology, University of Miami Miller School
of Medicine, Miami, FL *CR
2774 — A0156 IFN-γ influences the
proliferation and differentiation of
conjunctival goblet cells. Terry G. Coursey, J.
Tukler Henriksson, M. Chen, S. C. Pflugfelder.
Ophthalmology, Ocular Surface Center, Baylor
College of Medicine, Houston, TX
Tuesday Posters
8:30 am – 10:15 am
2775 — A0157 Automated quantitative
analysis of conjunctival microcirculation. Che
Liu1, H. Jiang1, J. Wang1, Z. Xu1, 2, A. Tao1, 2,
D. DeBuc1. 1Ophthalmology, Bascom Palmer
Eye Institute, Miami, FL; 2Ophthalmology and
Optometry, Wenzhou Medical College, Wenzhou,
China
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Neuro-Ophthalmology
315 Oculoplastics
Moderator: Ann P. Murchison
2776 — A0255 The learning curve for
endoscopic endonasal dacryorhinostomy. Sungbok Lee1, K. Kim1, H. Lee1, J. Kim1, S. Seo2, H.
Ahn3, H. Lee1. 1Chungnam National University
College of Medicine, Daejeon, Republic of
Korea; 2Gyeongsang National University College
of Medicine, Jinju, Republic of Korea; 3Dong-A
University College of Medicine, Busan, Republic
of Korea
2777 — A0256 External Transconjunctival
Dacryocystorhinostomy: Success without
disfiguring scar. Suryasnata Rath1, A. Ganguly1, S.
Mohapatra1, K. RamaRao2. 1Ophthalmic Plastics,
Orbit and Oncology, L V Prasad Eye Institute,
Bhubaneswar, India; 2Anatomy, Kalinga Institute of
Medical Sciences, Bhubaneswar, India
2778 — A0257 An alternative
technique describing laser-assisted
conjunctivodacryocystorhinostomy (CDCR)
using the 532nm diode laser. Neel Kumar1, 2,
D. Lazar1, 2, A. B. al-Hariri1, 3. 1Ophthalmology,
Ochsner Clinic Foundation, New Orleans,
LA; 2Ophthalmology, Louisiana State Univ
& Ochsner Clinic Fdtn, New Orleans,
LA; 3Ophthalmology, Worley & Hariri Oculoplastic
Surgery, New Orleans, LA
2779 — A0258 Ocular Complications Following
Acoustic Neuroma Resection. Ian Kirchner, S. A.
Kondapalli, D. K. Yoo, C. S. Bouchard. Department
of Ophthalmology, Loyola University Chicago
Stritch School of Medicine, Maywood, IL
2780 — A0259 Is exenteration must in each
case of adenoid cystic carcinoma of lacrimal
gland? Vishnukant Ghonsikar1, N. Pushker1, M.
Bajaj1, B. Chawla1, S. Kashyap1, S. Bakhshi2, S.
Sen1. 1DR R P Centre For Ophthalmic Sciences,
AIIMS, New delhi, India; 2Medical Oncology, Dr.
B.R.A. Institute Rotary Cancer Hospital, AIIMS,
New delhi, India
2781 — A0260 Orbital volume replacement
after enucleation: comparision between two
different sized implants using computed
tomography parameters. Rodrigo F.
Almeida1, 2, F. Emy1, I. L. Barbosa1, A.
P. Figueiredo1. 1Ophthalmolgy, Federal
University of Minas Gerais, Belo Horizonte,
Brazil; 2Oculoplastics, Instituto de Olhos de Belo
Horizonte, Belo Horizonte, Brazil f
2782 — A0261 Evisceration with Injectable
Hydrogel Implant. Elysa A. Brown, I. Koreen,
R. Yeatts. Ophthalmology, Wake Forest Medical
Center, Winston Salem, NC
2783 — A0262 Orbital Volume
Augmentation Using Expandable Hydrogel
Implants in Acquired Anophthalmia and
Phthisis Bulbi. Esther Lee1, 2, C. Bernardino3,
F. Levin2.1Ophthalmology, University of
Southern California Eye Institute, Los Angeles,
CA; 2Ophthalmology, Yale University, New Haven,
CT; 3Oculoplastics and Aesthetic Surgery, Vantage
Eye Center, Monterey, CA
2784 — A0263 Review of Ocular Findings in
Patients With Orbital Wall Fractures: A 5 -Year
Retrospective Analysis. Heidi Eiseman, M. E.
Rauser, S. Terrill, S. Choi. Ophthalmology, Loma
Linda University, Loma Linda, CA
2785 — A0264 Evaluation and management
outcomes of orbital wall fractures presenting
to a tertiary hospital in Singapore. Dinesh
Gunasekeran1, P. Tan2, E. Goh2. 1Yong
Loo Lin School of Medicine, National
University of Singapore (NUS), Singapore,
Singapore; 2Ophthalmology, National Healthcare
Group Eye Institute, Tan Tock Seng Hospital,
Singapore, Singapore
2786 — A0265 Effect of creams and gels
used as lubricant in the resistance of silicone
tubes. Jacqueline M. Sousa, M. Dittrich, P.
Bersanetti, R. Nogueira, P. Schor, S. Bison.
UNIFESP, São Paulo, Brazil
2787 — A0266 Comparison of Complication
Rates of Medpor versus Silicone Spherical
Orbital Implants. Charity H. Grannis1, S. Falcone2,
R. Mancini1. 1Ophthalmology, UT Southwestern,
Dallas, TX; 2Management, University of New
Mexico, Albuquerque, TX
2788 — A0267 Retrospective review to evaluate
the collaborative management and multidisciplinary approach to skull-base pathology at
a Tertiary medical center. Julie Linden1, P. Batra2,
K. Itani1, R. Mancini1. 1Ophthalmology, University
of Texas Southwestern Medical Center, Dallas,
TX; 2Otorhinolaryngology, University of Texas
Southwestern Medical Center, Dallas, TX
2789 — A0268 Canalicular Laceration Repair:
An Analysis of Variables Affecting Success. Ann
P. Murchison1, 2, J. R. Bilyk2. 1Emergency
Department, Wills Eye Hospital, Philadelphia,
PA; 2Skull Base Division, Neuro-Ophthalmology
Service, Wills Eye Hospital, Philadelphia, PA
2790 — A0269 Surgical and Epidemiologic
Factors Affecting Canalicular Laceration
Repair with the Mini Monoka Monocanalicular
Stent. Blair K. Armstrong1, M. Rabinowitz2,
B. Kenney3, R. Penne2. 1Wills Eye Hospital,
Philadelphia, PA; 2Oculoplastic and Orbital
Surgery Service, Wills Eye Hospital, Philadelphia,
PA; 3Research, Wills Eye Hospital, Philadelphia, PA
2791 — A0270 Canalicular lacerations:
demographic analysis and management
experience from a level one trauma center. Irina
Belinsky, C. C. Lo, P. Patel, C. Petris, E. Kim.
Ophthalmology, NYU Langone Medical Center,
New York, NY
2792 — A0271 Characterisation of the
Lacrimal Punctum using Spectral Domain
Anterior Segment Optical Coherence
Tomography: An Exploratory Study. Hannah
Timlin, P. Keane, A. Day, M. Abdullah, D. Ezra.
Moorfields Eye Hosptial, London, United Kingdom
2793 — A0272 Comparison of Brow Lifting
Techniques with Correlation to Dry Eye
Syndrome and Lagophthalmos. Krysta Goslin2,
C. Czyz1, 2, C. Nabavi1, 2, S. Zhang-Nunes1, 2, K.
Cahill1, 2, J. Foster1, 2. 1Oculoplastics, Ophthalmic
Surgeons and Consultants of Ohio, Columbus,
OH; 2Ophthalmology, Ohio State University,
Columbus, OH *CR
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Lens
316 Cataract surgery II
Moderator: Linda Musil
2794 — A0379 Cataract surgery in HIV
patients. Grace Chew, S. C. Teoh. Tan Tock Seng
Hospital, Singapore, Singapore
206
2795 — A0380 Visual and cognitive
improvement following cataract surgery
in dementia patients. Jonathan H. Lass1, 3, J.
Belkin1, T. Steinemann1, T. Majer4, A. Lerner2, S.
Debanne3, G. Gilmore4. 1Ophthalmology and Visual
Sciences, Case Western Reserve Univ, Cleveland,
OH; 2Neurology, Case Western Reserve University,
Cleveland, OH; 3Epidemiology and Biostatistics,
Case Western Reserve University, Cleveland,
OH; 4School of Applied Social Sciences, Case
Western Reserve University, Cleveland, OH f
2796 — A0381 A novel Clinical Characteristics
of Complicated Cataract in Retinitis
Pigmentosa. Min Hou, M. Wu, Y. Liu, B. Cheng,
D. Zheng, Y. Liu. Zhongshan Ophthamic Center,
Guangzhou, China
2797 — A0382 Cataract Surgery for
Keratoconus: Timing and Outcomes. David
Truong, R. Bowman. Ophthalmology, UT
Southwestern Medical Center, Dallas, TX
2799 — A0384 Brown-McLean syndrome in
a pediatric patient and literature review. Jaime
D. Martinez1, A. K. Tourkmani-Masri1, A. Galor2, 3,
F. Beltran1. 1Asociacion para Evitar la Ceguera,
Mexico, Mexico; 2Ophthalmology department,
Miami Veterans Affairs Medical Center, Miami,
FL; 3Bascom Palmer Eye Institute, Miami, FL
2800 — A0385 Large capsulorrhexis with
7-mm diameter intraocular lens implantation
for cataract surgery in the eyes with diabetes
mellitus. Makoto Gozawa, Y. Takamura, T.
Tomomatsu, T. Matsumura, Y. Takihara, M. Inatani.
ophthalmology, University of Fukui, Eiheiji-cho,
Japan f
2801 — A0386 Risk factors for Intraoperative
Floppy Iris Syndrome in Women. Komal Joshi1,
S. Muylaert1, 2, T. Chou1. 1Ophthalmology, State
University of New York Stony Brook, Stony Brook,
NY; 2New York Eye and Ear Infirmary, New York,
NY
2803 — A0388 Visual Outcome of Cataract
Surgery in Patients With Chronic Uveitis With
or Without Intraocular Lens. Eliott Kim1, D. S.
Chu1, 2, A. Ragam1. 1Rutgers University, Newark,
NJ; 2Metropolitan Eye Research and Surgery
Institute, Palisades Park, NJ *CR
2804 — A0389 Use of mini-capsulorhexis in the
Phaco-Ersatz technique for cataract surgery in
a rabbit model. Esdras A. Arrieta1, M. C. Aguilar1,
A. Arboleda1, 2, M. Taneja1, 3, P. Vaddavalli3, J.
Moilanen4, 5, F. Manns1, 2, V. Hernandez1, 2, J.
Watling5, J. A. Parel1, 5. 1Ophthalmic Biophysics
Center, Bascom Palmer Eye Institute, University
of Miami Miller School of Medicine, Miami,
FL; 2Department of Biomedical Engineering,
University of Miami College of Engineering, Coral
Gables, FL; 3LV Prasad Eye Institute, Hyderabad,
India; 4Helsinki University Central Hospital,
Helsinki, Finland; 5Vision Cooperative Research
Centre, Brien Holden Vision Institute, UNSW,
Sydney, NSW, Australia *CR
2805 — A0390 Cataract surgery and Straylight
in patients with Retinitis Pigmentosa. Thomas
J. Van Den Berg1, M. C. van Bree2, I. van
den Born2. 1Straylight Lab, Netherlands
Inst for Neurosci, Royal Acad, Amsterdam,
Netherlands; 2Rotterdam Eye Hospital, Rotterdam,
Netherlands *CR, f
2806 — A0391 Standardizing cataract
surgery rating between resident and attending
ophthalmologists: An educational intervention.
Michael Nolan1, A. Pittner1, W. McGaghie3,
G. Hill2, S. Dwarakanathan2, R. Feder4, A. V.
Farooq5, A. Traish5, C. S. Bouchard1. 1Department
of Ophthalmology, Loyola University Medical
Center, Maywood, IL; 2Leischner Institute for
Medical Education, Loyola University Stritch
School of Medicine, Maywood, IL; 3Division
of Ophthalmology, John H. Stroger, Jr. Hospital
of Cook County, Chicago, IL; 4Department of
Ophthalmology, Northwestern University, Chicago,
IL; 5Department of Ophthalmology and Visual
Sciences, University of Illinois at Chicago, Chicago,
IL
2807 — A0392 Mature Cataract Surgery
Outcomes Stratified by Surgeon Experience.
Ankur Gupta, S. M. Johnson, J. Nunn, E. Areiter.
Department of Ophthalmology, University of
Virginia School of Medicine, Charlottesville, VA
2809 — A0394 Outcomes of resident performed
mature cataract surgery: A 1 year study. Jonathan
Huz, N. Kalbag, A. S. Khouri. The Institute of
Ophthalmology and Visual Science, Rutgers New
Jersey Medical School, Newark, NJ
2810 — A0395 Practice Patterns With Regards
to Management of Inadequate Capsular Support
for Intracapsular or Sulcus Intraocular Lens
Placement During Cataract Surgery. Rebecca
Sorenson, S. H. Tucker, I. U. Scott, G. C.
Papachristou. Ophthalmology, Penn State Milton S.
Hershey Medical Center, Hershey, PA
2811 — A0396 Cataract Surgery Quality of
Care: An Evaluation of International Cataract
Surgery Clinical Practice Guidelines. Connie
Wu, A. Wu, B. Young, D. Wu, P. B. Greenberg.
Warren Alpert Medical School at Brown University,
Providence, RI
2812 — A0397 Visual outcomes after
uncomplicated complex cataract surgery:
Malyugin ring versus iris hooks. Jacey Hanna,
N. Kalbag, A. S. Khouri. The Institute of
Ophthalmology and Visual Science, Rutgers New
2813 — A0398 Impact of lens thickness on
hyper mature cataract surgical complications:
preliminary results of a prospective study. Addou
Regnard Manar, F. Fajnkuchen, A. Bui, G. Chaine,
A. Giocanti-Auregan. Hopital Avicenne, Bobigny,
France
2814 — A0399 Endophthalmitis Prophylaxis
for Cataract Surgery in State versus Private
Institutions - Does it Vary? Lisa Dang, J. S.
Weiss. Ophthalmology, Louisiana State University/
Ochsner Medical Center, New Orleans, LA
2815 — A0400 Postoperative course of
patients undergoing phacoemulsification
cataract extraction with Malyugin Ring™ pupil
expansion. Jonathan Fay1, 2, A. Shrivastava1, 2,
P. Channa1, 2, A. Madu1, 2. 1ophthalmology,
Albert Einstein College of Medicine, New York,
NY; 2ophthalmology, Montefiore Medical Center,
New York, NY
2816 — A0401 Phacoemulsificaton Cataract
Extraction Complication Rates of Secondand Third-Year Residents at a High Volume
Academic Center in North Carolina with a
Integrated, Intensive Surgical Curriculum. Adam
Dao, K. Cohen. Ophthalmology, University of
North Carolina, Chapel Hill, NC
2808 — A0393 Resident Postoperative Cataract
Surgery Outcomes in Patients Receiving Toric
Intraocular Lenses. Christopher Hamamdjian, B.
Hughes, J. Ramocki, J. Suchomel. Ophthalmology,
Kresge Eye Institute, Detroit, MI
207
Tuesday Posters
8:30 am – 10:15 am
2798 — A0383 Functional visual improvement
after cataract surgery in eyes with agerelated macular degeneration; Results of the
Ophthalmic Surgical Outcomes Data (OSOD)
Project. Michael Stock1, 2, D. Vollman1, 2, E.
Baze3, 4, A. Chomsky5, 6, M. K. Daly7, 8, M. G.
Lawrence9, 10. 1Department of Ophthalmology and
Visual Sciences, Washington University School
of Medicine, St Louis, MO; 2St Louis VA Medical
Center, St Louis, MO; 3Michael E. DeBakey
VA Medical Center, Houston, TX; 4Cullen Eye
Institute, Baylor College of Medicine, Houston,
TX; 5VA Tennessee Valley Healthcare System
Center, Nashville, TN; 6Vanderbilt Eye Institute,
Vanderbilt University Medical School, Nashville,
TN; 7VA Boston Healthcare System, Boston,
MA; 8Havard University Medical School, Boston,
MA; 9Minnesota VA Medical Center, Minneapolis,
MN; 10Department of Ophthalmology & Visual
Neurosciences, University of Minnesota Medical
School, Minneapolis, MN
2802 — A0387 Safety and Efficacy of
Concomitant Prophylactic Sclerostomy
with Cataract Surgery in Eyes with
Nanonpthalmos. Sharmila Rajendrababu, G.
V. Puthuran, N. Babu. glaucoma, Aravind Eye
Hospital, Madurai, India *CR
Exhibit/Poster Hall SA B0050-B0098
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Immunology/Microbiology / Cornea / Retina
317 Clinical and Translational Studies
in Ocular Infection and Immunity
Moderator: Sunir Garg
Tuesday Posters
8:30 am – 10:15 am
2817 — B0050 Retinal vascular changes and
immune restoration in a cohort of HIV patients
on highly active antiretroviral therapy. Petrina
Tan1, L. Li2, O. Hee1, C. Y. Cheung2, R.
V. Agrawal1, T. Lim1, T. Y. Wong2, 3, S. C.
Teoh1. 1Ophthalmology, National Healthcare Group
Eye Institute, Tan Tock Seng Hospital, Singapore,
Singapore; 2Ophthalmology, Singapore Eye
Research Institute, Singapore National Eye Centre,
Singapore, Singapore; 3Ophthalmology, Yong Loo
Lin School of Medicine, National University of
Singapore, Singapore, Singapore
2818 — B0051 Pyroptosis and AIDS-related
human cytomegalovirus (HCMV) retinitis:
Caspase-1-dependent or caspase-1-independent
interleukin-1β expression in response to HCMV
infection is cell-type dependent. Richard D. Dix1, 2,
C. I. Alston1, H. Chien1. 1Department of Biology,
Georgia State University, Atlanta, GA; 2Department
of Ophthalmology, Emory University School of
Medicine, Atlanta, GA
2819 — B0052 Neuro-retinal degeneration in
HIV-positive children (NOVICE-study). Frank
D. Verbraak1, 2, N. Demirkaya1, S. Cohen3, D.
Pajkrt3, M. D. Abramoff4.1Ophthalmology,
Univ of Amsterdam Acad Med Ctr, Amsterdam,
Netherlands; 2Biomedical Engineering and
Physics, Academic Medical Center, Amsterdam,
Netherlands; 3Child Care, Academic Medical
Center, Amsterdam, Netherlands; 4Ophthalmology,
Iowa University Hospital, Iowa, IA
2820 — B0053 Neuroretinal degeneration
in HIV. Nazli Demirkaya1, F. Wit3, 4, T.
Su9, I. Stolte8, K. Kooij3, 4, T. J. Van Den
Berg5, M. D. Abramoff6, 7, P. Reiss3, 4, F. D.
Verbraak1, 2. 1Ophthalmology, Academic Med Ctr
Amsterdam, Amsterdam, Netherlands; 2Biomedical
Engineering and Physics, Academic Medical
Center, Amsterdam, Netherlands; 3Infectious
Diseases, Academic Medical Center, Amsterdam,
Netherlands; 4Amsterdam Institute for Global
Health and Development, Amsterdam,
Netherlands; 5Netherlands Ophthalmic Research
Institute, Amsterdam, Netherlands; 6Ophthalmology
and Visual Sciences, University of Iowa Hospital
and Clinics, Iowa, IA; 7Biomedical Engineering,
Iowa Institute for Biomedical Imaging, Iowa,
IA;8Municipal and Regional Health Service,
Amsterdam, Netherlands; 9Radiology, Academic
Medical Center, Amsterdam, Netherlands *CR
2821 — B0054 Knockdown of suppressor of
cytokine signaling (SOCS)1 or SOCS3 gene
expression during human cytomegalovirus
(HCMV) infection results in altered expression
of SOCS inducers and cell-type-dependent
SOCS expression. Hsin Chien1, C. I. Alston1,
R. D. Dix1, 2. 1Department of Biology, Georgia
State University, Atlanta, GA;2Department of
Ophthalmology, Emory University School of
2822 — B0055 Stimulation of Suppressor
of Cytokine Signaling (SOCS)1 and SOCS3
Expression by Murine Cytomegalovirus
(MCMV) Does Not Necessarily Require
Productive Virus Replication. Christine I.
Alston1, H. Chien1, M. K. Han1, J. E. Fleming1,
R. D. Dix1, 2. 1Department of Biology, Georgia
State University, Atlanta, GA; 2Department of
Ophthalmology, Emory University School of
2823 — B0056 Microbial patient and
operating room personnel sampling and culture
evaluation of an ambulatory ophthalmological
unit. A novel protocol. David J. Sackel1, A. J.
Kanellopoulos1, 2, G. Chatzilaou2, G. Asimellis2, L.
T. Sperber1. 1Ophthalmology, New York University,
New York, NY; 2Laservision.gr Eye Institute,
Athens, Greece *CR
2824 — B0057 Ocular Toxoplasmosis: Clinical
and serological correlation. Marcelo Valeiras, D.
Bar, V. Soledad, L. C. Gimena, V. Julián, G. Martín,
H. Sebastián, R. Uriel, D. Andrés, G. Iribarren.
Retina, hospital aleman, Buenos aires, Argentina
2825 — B0058 Trends of Methicillin- Resistant
Staphylococcus Aureus (MRSA) Keratitis in
Western Pennsylvania: A 14- year study. Victoria
Chang, R. P. Kowalski. UPMC, Pittsburgh, FL
2826 — B0059 The influence of non-steroidal
anti-inflammatory drug on the effects of
antifungal drug in treating experimental
fungal keratitis. Liya Wang1, 2, H. Zhang1, 2, S.
Liu1, 2, J. Li1, 2, H. Liu1, 2, Y. Xie1, 2. 1Henan Eye
Institute, Zhengzhou, China; 2Henan Eye Hospital,
zhengzhou, China
2827 — B0060 Tacrolimus for the
Treatment of Subepithelial Infiltrates
Resistant to Topical Steroids After Adenoviral
Keratoconjunctivitis. Juliana Ferreira da
Costa Vargas1, R. Coral Ghanem2, V. Coral
Ghanem2. 1Universidade da Região de Joinville
- UNIVILLE, Joinville, Brazil; 2Sadalla Amin
Ghanem Eye Hospital, Joinville, Brazil
2828 — B0061 Unilateral Diffuse Nummular
Infiltrates and Microcystic Edema Secondary to
Lyme Disease in the Pediatric Population. Mikel
S. Ehntholt1, G. W. Zaidman2, 1.1New York Medical
College, Valhalla, NY; 2Ophthalmology, Westchester
Medical Center, Valhalla, NY
2829 — B0062 Demodex infestation as a
potential cause of keratitis. Lingyi Liang, Y. Chen,
C. Li, J. Chen. Zhongshan Ophthalmic Center,
Guangzhou, China
2830 — B0063 Outcome of Late-onset
Keratitis Complicating the Implantation of
Intrastromal Corneal Ring Segments. Samar A.
Al-Swailem1, M. AL-Jindan2. 1Anterior Segment,
King Khaled Eye Specialist Hosp, Riyadh, Saudi
Arabia; 2Ophthalmology, King Fahad Teaching
hospital of Alkhobar, Alkhobar, Saudi Arabia
2831 — B0064 Multiplex PCR Assay
for Screening of Mycotoxin genes from
Ocular Isolates of Fusarium species. Orapin
Anutarapongpan1, 2, J. Maestre1, R. A. Oechsler1, 3,
E. C. Alfonso1, T. P. O’Brien1, D. Miller1. 1Bascom
Palmer Eye Institute, Miller School of Medicine,
University of Miami, Miami, FL; 2Ophthalmology,
Faculty of Medicine, Srinagarind Hospital,
Khon Kaen University, Khon Kaen,
Thailand; 3Ophthalmology, Federal University of
São Paulo, São Paulo, Brazil
2832 — B0065 Case series of severe microbial
keratitis in young patients secondary to cosmetic
contact lens use. Carrie Zaslow, A. Steiner, V.
Boniuk, J. Winokur, I. J. Udell. North Shore LIJ
Department of Ophthalmology, New Hyde Park,
NY
2833 — B0066 Aciclovir Effect As Antifungal
Adjuvanted On Fungi Isolated From Patients
With Keratitis. Daniela Castro Farías, J. R.
Herrerías Vilmamil, V. M. Bautista, H. MejiaLopez. Research Unit/Department of Microbiology
and Proteomics, Institute of Ophthalmology Conde
de Valenciana, México, Mexico
2834 — B0067 Acanthamoeba keratitis: 8
years survey with Broad-range real-time PCR
and culture. Pablo L. Goldschmidt1, S. Degorge1,
L. Merabet1, F. Daban1, C. Temstet1, L. Batellier1, V.
Borderie2, L. Laroche2, C. Chaumeil1. 1Laboratoire,
Quinze Vingts Nt, Paris, France; 2Service 5, Quinze
Vingts Nt Eye Center, Paris, France
2835 — B0068 Sterile Vitritis after
Keratoprosthesis Implantation: Incidence,
Management, and Outcomes. Rosalind C. Vo,
J. K. Alexander, A. J. Aldave. Jules Stein Eye
Institute, Los Angeles, CA
2836 — B0069 Microbiological study of corneal
ulcer patients at Bellevue Hospital Center. Feilin
Zhu, L. Park, E. J. Cohen. Dept of Ophthalmology,
NYU Medical Center, New York, NY
2837 — B0070 Epidemic Keratoconjunctivitis
in India: Is it adenoviral or
microsporidial? Praveen K. Balne1, S. Sharma1, S.
Das2, S. K. Sahu2. 1Jhaveri Microbiology Centre, L
V Prasad Eye Institute, Hyderabad, India; 2Cornea
and Anterior Segment Services, L V Prasad Eye
Institute, Bhubaneswar, India
2838 — B0071 Experience with valganciclovir
in the treatment of presumed Epstein - Barr
Virus (EBV)-associated uveitis. Ninani Kombo,
C. Foster. Massachusetts Eye Research and Surgery
Insitution, Cambridge, MA
208
2839 — B0072 Epidemiology And Outcomes Of
Kocuria Keratitis. Arturo J. Ramirez-Miranda1, J.
L. Pedro Aguilar1, V. M. Bautista2, M. Ortiz-Casas2,
A. Navas1, E. O. Graue1. 1Cornea and Refractive
Surgery, Instituto de Oftalmologia “Conde de
Valenciana”, Mexico City, Mexico; 2Microbiology,
Instituto de Oftalmologia “Conde de Valenciana”,
Mexico City, Mexico
2840 — B0073 In vitro Antibiotic Susceptibility
Profile of Ocular Pathogens - Results from
the First ARMOR Canada Surveillance
Study. Joseph M. Blondeau1, C. M. Sanfilippo2,
T. W. Morris2, J. Deane3, D. F. Sahm3. 1Clinical
Microbiology, Royal University Hospital,
Saskatoon, Canada; 2Microbiology and Sterilization
Sciences, Bausch & Lomb Incorporated, Rochester,
NY; 3Eurofins Medinet, Chantilly, VA *CR
2841 — B0074 Toxoplasma gondii serotype
associated with patients experiencing severe
ocular toxoplasmosis in Brazil. Alessandra
Commodaro1, C. Muccioli2, C. Silveira2, L. V.
Rizzo3, R. Belfort, Jr.2, M. Grigg1. 1NIAID, National
Institute of Heallth, Bethesda, MD; 2Ophthalmolgy,
Federal University of São Paulo, São Paulo,
Brazil; 3Hospital Albert Einstein, São Paulo, Brazil
2843 — B0076 Association of toxocara
infection with central serous chorioretinopathy
(CSC). Yoon Hyung Kwon1, N. Kim1, Y. Kim2,
W. Ryu1, H. Ahn1. 1ophthalmology, Dong-A
University, college of medicine, Busan, Republic of
Korea; 2Anatomy, mitochondria hub center, Dong-A
University, College of Medicine, busan, Republic
of Korea
2844 — B0077 Epidemiological and clinical
characteristics of presumed ocular tuberculosis:
a 12-year experience in a tertiary center in
Brazil. Inara Contin1, J. F. Ramos2, O. H. Leite2,
C. E. Hirata1, J. H. Yamamoto1. 1Ophthalmology,
Universidade de São Paulo, Faculdade de Medicina,
São Paulo, Brazil; 2Infectious Disease, Universidade
de São Paulo, Faculdade de Medicina, São Paulo,
Brazil
2845 — B0078 Comparing Culturing
Techniques in Corneal Ulcers. Aaron
J. Smith1, T. Smith2, S. Hoadley1, K. W.
Crowder1. 1Ophthalmology, Univ of Mississippi
Medical Center, Jackson, MS; 2jackson eye
associates, jackson, MS
2846 — B0079 In Vivo Confocal Microscopy
Reveals Differential Corneal Immune Response
in Patients with Central vs. Peripheral HSV
Keratitis. Rodrigo T. Muller1, R. Pourmirzaie1,
S. Aggarwal1, B. M. Cavalcanti1, A. Jamali2, D.
Langston1, P. Hamrah1, 2. 1Massachusetts Eye
and Ear Infirmary, Boston, MA; 2Schepens Eye
Research Institute, Boston, MA
2848 — B0081 Clinical characteristics of acute
retinal necrosis: an 8-year review. Shriji Patel, R.
J. Rescigno, M. Zarbin, P. D. Langer, N. Bhagat.
Institute of Ophthalmology & Visual Science,
Rutgers New Jersey Medical School, Newark,
NJ *CR
2849 — B0082 Intravitreal Clindamycin
And Dexamethasone For Ocular
ToxoplasmosiS. Carlos A. Abdala1, M. P.
Muñoz2. 1Retina & Vitreous, Unidad Laser Clinica
Oftalmologica, Barranquilla, Colombia; 2Retina
and Vitreous, Clinica Oftalmologica de Cartagena Universidad del Sinu, Cartagena, Colombia
2850 — B0083 Utility and costs of ophthalmic
consultation for fungemia. Devon Ghodasra,
K. Eftekhari, A. R. Shah, B. L. VanderBeek.
Scheie Eye Institute, University of Pennsylvania,
Philadelphia, PA
2851 — B0084 Is Acanthamoeba
Castellanii sensitive to magnetic fields? Esteban
Perez1, D. Miller2, 3, A. Arboleda1, M. Taneja1, 4, W.
Lee1, M. C. Aguilar1, F. Cabot1, 3, V. Sargent1, G.
Amescua3, J. A. Parel1, 5. 1Ophthalmic Biophysics
Center, Bascom Palmer Eye Institute, University of
Miami Miller School Medicine, Miami, FL; 2Ocular
Microbiology Laboratory, Bascom Palmer Eye
Institute, University of Miami Miller School of
Medicine, Miami, FL; 3Anne Bates Leach Eye
Hospital, Bascom Palmer Eye Institute, University
of Miami Miller School of Medicine, Miami, FL; 4L
V Prasad Eye Institute, Hyderabad, India; 5Vision
Cooperative Research Centre, Brien Holden Vision
Institute, UNSW, Sydney, NSW, Australia
2852 — B0085 Dexamethasone Intravitreal
Implant in the Treatment of Persistent
Uveitic Macular Edema in the Absence of
Active Inflammation. Jennifer Cao1, M. L.
Mulvahill3, L. Zhang3, B. C. Joondeph2, M. S.
Dacey2. 1Ophthalmology, University of Colorado,
Denver, CO; 2Colorado Retina Associates, Denver,
CO; 3School of Public Health, University of
Colorado, Aurora, CO *CR
2853 — B0086 The In Vitro Evaluation of the
Virucidal Efficacy of Povidone-Iodine against
Multiple Ocular Adenoviral Types. Eric G.
Romanowski, K. E. Oconnor, K. A. Yates, R. M.
Shanks, R. P. Kowalski. The Charles T. Campbell
Laboratory, UPMC Eye Center, University of
Pittsburgh, Pittsburgh, PA
2854 — B0087 Long-term outcome of patients
with cytomegalovirus-induced anterior uveitis
treated with antiviral therapy. Mo Lise Qu1, M.
Angi1, V. Touitou1, E. Champion1, F. Rozenberg2,
P. Lehoang1, B. Bodaghi1. 1Ophthalmology, DHU
ViewMaintain, Pitie Salpetriere Hospital, Paris,
France; 2Virology, Cochin, Paris, France
2855 — B0088 Rose Bengal- and Riboflavinmediated Photodynamic Therapy of Fungal
Keratitis Isolates. Alejandro Arboleda1, 2, D.
Miller3, 4, F. Cabot1, 4, M. Taneja1, 5, M. C. Aguilar1,
K. Alawa1, 2, E. Perez1, G. Amescua4, S. H. Yoo1, 4, J.
A. Parel1, 6. 1Ophthalmic Biophysics Center, Bascom
School of Medicine, Miami, FL; 2Department of
Biomedical Engineering, University of Miami
College of Engineering, Coral Gables, FL; 3Ocular
Institute, University of Miami Miller School
of Medicine, Miami, FL; 4Anne Bates Leach
Eye Hospital, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 5LV Prasad Eye Institute, Hyderabad,
India; 6Vision Cooperative Research Centre, Brien
Holden Vision Institute, UNSW, Sydney, NSW,
Australia
2856 — B0089 Idiopathic multifocal choroiditis
(MFC)/punctate inner choroidopthy (PIC) with
acute photoreceptor loss out of proportion to
clinically visible lesions. Marion R. Munk1, 2,
J. J. Jung3, 4, K. Biggee6, U. Schmidt-Erfurth2,
W. R. Tucker5, H. Sen5, 7, A. A. Fawzi1, L. M.
Jampol1. 1Dept of Ophthalmology, Northwestern
University, Feinberg School of Medicine, Chicago,
IL; 2Department of Ophthalmology, Medical
University Vienna, Vienna, Austria; 3Department
of Ophthalmology, New York University School
of Medicine, New York, NY;4Vitreous Retina
Macula Consultants of New York, New York,
NY; 5Department of Ophthalmology, National Eye
Institute, National Institute of Health, Bethesda,
MD; 6Department of Ophthalmology, Casey Eye
Institute/Oregon Health and Science, Portland,
OR; 7Department of Ophthalmology, THe George
Washington University, Washington, WA
2857 — B0090 Endophthalmitis Caused
by Streptococcal Species: Clinical
Settings, Microbiology, Management, and
Outcomes. Harry W. Flynn, A. E. Kuriyan, W.
Smiddy, A. M. Berrocal, T. A. Albini, D. Miller.
University of Miami, Miami, FL
2858 — B0091 Assessment Of Retinal
Vasculitis Using The Retinal Function Imager
(RFI). Nicole Stuebiger1, A. Tao2, 3, W. Lee2,
S. Pineda2, H. Jiang2, J. Wang2, J. L. Davis2,
D. DeBuc2. 1Department of Ophthalmology,
Charite, University Medicine Berlin, Berlin,
Germany; 2Bascom Palmer Eye Institute,
University of Miami, Miami, FL;3Ophthalmology
and Optometry, School of Ophthalmology and
Optometry, Wenzhou Medical College, Wenzhou,
China *CR
2859 — B0092 Systemic treatment
with glutathione PEGylated liposomal
methylprednisolone (2B3-201) improves
therapeutic efficacy in a model of ocular
inflammation. Arie Reijerkerk, C. C. Appeldoorn,
J. Rip, M. de Boer, P. Gaillard. to-BBB technologies
BV, Leiden, Netherlands *CR
209
Tuesday Posters
8:30 am – 10:15 am
2842 — B0075 20-year experience of Birdshot
Chorioretinopathy: Prognostic factors of
long-term visual outcome. SARA TOUHAMI,
C. Fardeau, C. Simon, J. Knoeri, B. Bodaghi, P.
Lehoang. Ophthalmology, Pitié Salpétrière Hospital,
Paris, France
2847 — B0080 Recurrent toxoplasmic
retinochoroiditis: a study of 58 cases with initial
aqueous humor analysis. Alexandre Matet, E.
Champion, V. Touitou, C. Fardeau, C. Terrada,
N. Cassoux, L. Paris, P. LeHoang, B. Bodaghi.
Ophthalmology, DHU ViewMaintain, Pitie
Salpetriere Hospital, Paris, France
2860 — B0093 Visual Function and Macular
Architecture in Patients with Inactive Zones
2 and 3 Toxoplasmic Retinochoroiditis. Tiago
E. Arantes, M. H. Azevedo, G. L. Moura, E. N.
Camilo, B. M. Cavalcanti. Fundação Altino Ventura,
Recife, Brazil
2861 — B0094 Antimicrobial susceptibility
profile of viridans group streptococci isolated
from endophthalmitis. Katiane Santin, P.
Bispo, A. L. Hofling-Lima. Visual Sciences and
Ophthalmology, UNIFESP, São Paulo, Brazil
Tuesday Posters
8:30 am – 10:15 am
2862 — B0095 Are liquid media useful
in the laboratory diagnosis of infective
endophthalmitis? Swapna R. Motukupally1, V.
Sethi2, S. Sharma1, A. Mathai2, K. Chathoth1, V.
Nanapur1. 1Jhaveri Microbiology Centre, L V Prasad
Eye Institute, Banjara Hills, Hyderabad, India; 2Smt.
Kannuri Santhamma Centre for Vitreo-retinal
Diseases, LV Prasad Eye Institute, Banjara Hills,
Hyderabad, India
2863 — B0096 Prevalence of Accessory
Gene Regulator (AGR) subtypes, DeltaHemolysin (HLD) toxin, and correlation with
Biofilm production among Staphylococcus
epidermidis endophthalmitis isolates. James
Wong2, 1, L. C. Huang2, J. Stringham1, J. Maestre1,
D. Miller1, H. W. Flynn1, 2. 1Bascom Palmer Eye
Institute, Miami, FL; 2University of Miami School
of Medicine, Miami, FL
2864 — B0097 Anti-adhesive, bactericidal and
lytic effects of taurolidine on biofilm formation:
in vitro endophthalmitis model. Zainab
Bentaleb-Machkour1, F. Benbouzid1, F. Renaud2,
S. Balvay2, P. Rivory2, D. Hartmann2, P. Denis1,
L. Kodjikian1. 1Ophthalmology, Croix-Rousse
Hospital, Lyon, Lyon, France; 2Biomaterials and
Biological Interactions, Microbiology Laboratory,
Lyon I University, Lyon, France
2865 — B0098 Endophthalmitis caused
by Staphylococcus epidermidis: SCCmec
Types and Prevalence of the Panton-Valentine
Leukocidin (PVL) Toxin. Jack Stringham1, J.
Wong1, 2, L. C. Huang2, J. Maestre1, D. Miller1, H.
W. Flynn1, 2. 1Bascom Palmer Eye Institute, Miami,
FL; 2University of Miami School of Medicine,
Miami, FL
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Immunology/Microbiology
318 Posterior Segment Infection and
Inflammation #1
Moderator: Phillip S. Coburn
2866 — B0099 Regional heterogeneity in the
endothelial glycocalyx and basement membrane
of the retinal vasculature. Marie N. O›Connor1,
S. Nourshargh2, J. Greenwood1.1Cell Biology,
UCL Institute of Ophthalmology, London, United
Kingdom; 2William Harvey Research Institute,
Barts and The London School of Medicine and
Dentistry, Queen Mary University of London,
London, United Kingdom
2867 — B0100 Distribution of glycoprotein
B and UL144 genotypes in immunocompetent
patients with cytomegalovirus endotheliitis and
iridocyclitis. Naoko Oka, T. Suzuki, T. Inoue, T.
Kobayashi, Y. Ohashi. Ehime university School of
Medicine, Toon, Japan
2868 — B0101 Characterization of ocular
lesions in gp91phox-/- and p47phox-/- mice with
ocular pathological features of human chronic
granulomatous disease. Yujuan Wang1, 2, E. L.
Falcone3, D. Shen1, M. S. Abu-Asab4, A. Ogilvy4,
S. M. Holland3, C. Chan1, 4. 1Immunopathology
Section, Laboratory of Immunology, National Eye
Institute, Bethesda, MD; 2State Key Laboratory
of Ophthalmology, Zhongshan Ophthalmic
Center, Sun Yat-sen University, Guangzhou,
China; 3Immunopathology Section, Laboratory
of Clinical Infectious Diseases, National Institute
of Allergy and Infectious Diseases, Bethesda,
MD; 4Histopathology Core, Laboratory of
Immunology, National Eye Institute, Bethesda, MD
2869 — B0102 Ocular Toxoplasmosis: Clinical
Features in 279 Patients from Central Cuba. Jose
D. Diaz1, J. Bustillo2, D. C. Gritz1. 1Albert Einstein
College of Medicine, Bronx, NY; 2Instituto Superior
de Ciencias Médicas de Sancti Spiritus, Sancti
Spiritus, Cuba
2870 — B0103 The role of CodY in S. aureus
endophthlamitis. Ama Sadaka2, 1, T. Suzuki3, K.
Palmer4, M. Gilmore2. 1University of Cincinnati,
Cincinnati, OH; 2Massachusetts Eye and Ear
Infirmary, Cincinnati, OH; 3Ehime University,
Matsuyama, Japan; 4University of Texas, Dallas, TX
2871 — B0104 Toll-like receptor 3 is expressed
in all layers of the human retina. Mohammed
Qutub, N. Vilà, S. Maloney, D. Faingold, N.
AlSaati, E. Antecka, M. N. Burnier. Henry C.
Witelson Ocular Pathology Laboratory, McGill
University, Montreal, QC, Canada
2872 — B0105 Role of MyD88-dependent
and MyD88-independent Pathways in Bacillus
cereus Endophthalmitis. S.Madhumathi
Parkunan1, A. M. Roehrkasse2, R. L. Staats3, M. C.
Callegan4, 5. 1Microbiology & Immunology, Univ
of Oklahoma Hlth Sciences Ctr, Oklahoma City,
OK; 2Biology, Oklahoma Christian University,
Oklahoma City, OK; 3Animal Sciences, Oklahoma
State University, Stillwater, OK; 4Ophthalmology,
University of Oklahoma Health Sciences Center,
Oklahoma City, OK; 5Dean McGee Eye Institute,
Oklahoma City, OK
2873 — B0106 An ex vivo model of postintravitreal injection endophthalmitis using
enucleated pig eyes. Douglas Sigford, S. Schaal,
Q. Zeng, A. Palacio, Y. Barak, T. H. Tezel.
Ophthalmology and Visual Science, University of
Louisville, Louisville, KY
2874 — B0107 Effect of Enzymatic Vitreolysis
with Plasmin on Intravitreal Antibiotics
Therapy in a Mouse Model of Staphylococcal
Endophthalmitis. Joaquin Tosi, P. K. Singh, A.
Kumar. Ophthalmology, Kresge Eye Institute,
Detroit, MI
2875 — B0108 Retinal Pigment Epithelium
Dysfunction Facilitates Endogenous Bacterial
Endophthalmitis. Phillip S. Coburn1, F. C.
Miller2, M. C. Callegan1. 1Ophthalmology, The
Univ of Oklahoma Hlth Sci Ctr, Oklahoma City,
OK; 2Biology, Oklahoma Christian University,
Edmond, OK
2876 — B0109 In Vivo Scoring of the
Endotoxin-Induced Uveitis Model using Optical
Coherence Tomography: Comparison with
Fundus Imaging and Histology. Abrar A. Rageh1,
H. Roehrich1, S. Abdullah2, B. Burckhard3, D.
A. Ferrington1, S. Montezuma1. 1Ophthalmology,
University of Minnesota, Minneapolis,
MN; 2Medical School, University of Minnesota,
Minneapolis, MN; 3Medical School, University of
North Dakota, Grand Forks, ND
2877 — B0110 IL6: a new target for
the treatment of ocular toxoplasmosis
recurrence? Elise Rochet1, A. Pfaff1, T. Bourcier2,
E. Candolfi1, 2. 1Institut de Parasitologie et
Pathologie Tropicale, Strasbourg, France; 2Hôpitaux
Universitaires de Strasbourg, Strasbourg, France
2878 — B0111 Mycobacterium tuberculosis
secreted protein ESAT-6 activates the
NLRP3 inflammasome in retinal pigment
epithelium. Soumyava Basu1, 2, N. Kerur1, B. J.
Fowler1, J. Ambati1. 1Department of Ophthalmology,
University of Kentucky, Lexington, KY; 2L V
Prasad Eye Institute, Bhubaneswar, India *CR
2879 — B0112 Green tea extract as a multiple
compound is the most potent anti-inflammatory
agents in endotoxin-induced uveitis. Yongjie
Qin1, K. Chu1, Y. Yip1, W. Li1, S. Chan2, C. Pang1.
1
Ophthalmology and visual sciences, CUHK., Hong
Kong, Hong Kong; 2School of Biomedical Sciences,
CUHK, Hong Kong, Hong Kong
210
2880 — B0113 Intravitreal dexamethasone
implant in non-infectious uveitis : a one-year
follow-up. Emmanuelle Champion, J. Cardoso,
A. Darugar, A. Fel, V. Touitou, P. Lehoang, B.
Bodaghi. Ophthalmology, DHU ViewMaintain,
Pitie Salpetriere Hospital, Paris, France
2881 — B0114 Decrease in Hemoglobin
As the Cause of Interferon-Induced
Retinopathy. Meghan Berkenstock, F. McCartney,
J. M. Ackert. Ophthalmology, Drexel University
College of Medicine, Philadelphia, PA
2882 — B0115 Ex-press shunt implantation
in Uveitic Glaucoma. Swetha Dhanireddy, N. C.
Kombo, C. Foster. Massachusetts Eye Research and
Surgery Institution, Cambridge, MA
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Physiology/Pharmacology
319 Intraocular Pressure / Aqueous
humour dynamics
2883 — B0281 BK2A78: A novel nonpeptide bradykinin B2 agonist lowers
intraocular pressure (IOP) in ocular
hypertensive cynomolgus monkeys. Ganesh
Prasanna1, N. Sharif1, B. H. Li1, M. Hellberg1,
T. Krause1, S. Yacoub1, D. Scott1, C. R. Kelly1,
I. Pang2, K. Combrink1. 1Bio Med (NIBR)/
Ophthalmology Research, Novartis, Cambrige,
MA; 2Pharmaceutical Sciences, UNT Health
Science Center, Fort Wort, TX *CR
2884 — B0282 The Use of Tissue Plasminogen
Activator to Reduce Elevated Intraocular
Pressure Induced by Prednisolone in
Sheep. Oscar A. Candia1, R. Gerometta2, J.
Danias3. 1Ophthalmology, Mount Sinai School of
Medicine, New York, NY; 2Oftalmologia, UNNE,
Corrientes, Argentina; 3Ophthalmology, SUNY
Downstate Medical Center, Brooklyn, NY
2885 — B0283 Simulating the effect of
trabecular meshwork resistance and episcleral
venous pressure on conventional aqueous humor
outflow dynamics. James C. Tan1, E. R. Chu1, 2,
J. M. Gonzalez1, A. Yelenskiy1, M. K. Ko1, S. L.
Graham2, E. Kim1. 1Ophthalmology, Keck School
of Medicine, University of Southern California,
Los Angeles, CA; 2Australian School of Advanced
Medicine, Macquarie University, North Ryde, NSW,
Australia *CR
2886 — B0284 Differential effects
of nitric oxide synthase inhibitors on
conventional outflow facility in mice. Jason
Y. Chang1, 3, C. R. Ethier1, 2, W. Stamer3, D. R.
Overby1.1Bioengineering, Imperial College
London, London, United Kingdom; 2Biomedical
Engineering, Georgia Institute of Technology,
Atlanta, GA; 3Ophthalmology, Duke University,
Durham, NC
2888 — B0286 Role of Caveolin-1 in
Intraocular Pressure and Conventional Outflow
Regulation. Michael H. Elliott1, 2, X. Gu2, N.
E. Ashpole3, 4, G. L. Griffith1, T. M. Boyce1, M.
Tanito5, E. R. Tamm6, W. Stamer4. 1Ophthalmology/
Dean McGee Eye Institute, University of
Oklahoma Health Sciences Center, Oklahoma
City, OK; 2Oklahoma Center for Neuroscience,
University of Oklahoma Health Sciences
Center, Oklahoma City, OK; 3Biomedical
Engineering, University of Arizona, Tucson, AZ;
4
Ophthalmology/Duke Eye Center, Duke University,
Durham, NC; 5Ophthalmology, Shimane University
Faculty of Medicine, Shimane, Japan; 6Institute
of Human Anatomy, University of Regensburg,
Regensburg, Germany
2889 — B0287 Efficacy and Safety of Topical
New Sodium Pump Inhibitor (NSPI) in Reducing
Intraocular Pressure in a Canine Model. Jonathan
B. Jacobs1, 2, R. W. Hertle3, 4, J. Dunmire4, L.
F. Dell’Osso1, 2, L. A. Dalvin5, D. Yang3, M.
Evano-Chapman4. 1Daroff-Dell’Osso Ocular
Motility Lab, Cleveland VA Med Ctr, Cleveland,
OH; 2Neurology (School of Med) and Biomedical
Engr, Case Western Reserve University, Cleveland,
OH; 3Ophthalmology, Children’s Hospital Medical
Center of Akron, Akron, OH; 4Ophthalmology,
SUMMA Medical Center, Akron, OH; 5Graduate
Medical Education, Mayo Clinic, Rochester,
MN *CR
2890 — B0288 Effect Of Hydrogen SulfideReleaseing Compounds On Aqueous Humor
Dynamics. Ya Fatou Njie-Mbye1, J. Robinson1,
C. Ezeudu1, L. Mitchell1, M. Kulkarni-Chitnis1,
C. A. Opere2, S. E. Ohia1. 1Pharmaceutical
Sciences, Texas Southern University, Houston,
TX; 2Pharmacy Sciences, Creighton University,
Omaha, NE
2891 — B0289 Ocular Hypotensive Effect Of
Baicalein In Sprague-Dawley Rats. Hoi-Lam Li,
C. Leung, H. Chan, C. To, C. Do. The Hong Kong
Polytechnic University, Hong Kong, Hong Kong
2892 — B0290 Effects of brimonidine on
the intraocular pressure and blood-aqueous
barrier permeability after phacoemulsification
and intraocular lens implantation in glaucoma
subjects. Yoshiaki Kiuchi, K. Ideguchi, Y.
Sugimoto, T. Chikama. Ophthalmology & Visual
Science, Hiroshima University, Minami-Ku,
Japan f
2893 — B0291 Effect of Pilocarpine on
Intraocular Pressure and Schlemm’s Canal in
Experimental Glaucomatous Monkey Eyes.
Shenouda Yacoub, B. H. Li, R. Daly, S. S. Webb,
B. Thomas, G. Jernigan, Q. Sessums, D. Scott, G.
Prasanna, D. S. Rice. Glaucoma Research, Novartis
Institutes for Biomedical Research, Fort Worth,
TX *CR
2894 — B0292 Effect on physiologic
intraocular pressure of four topic formulations
of valsartan and its impact on conjunctival
irritation: a pilot study in rabbits. Oscar Olvera
Montaño, Y. Contreras Rubio, L. M. Baiza-Duran,
P. A. Márquez. Medical Management, Laboratorios
Sophia S.A. de C.V., Zapopan, Mexico *CR
2895 — B0293 In Vivo Dimensions of
Schlemm’s Canal in Normal and Experimental
Glaucomatous Monkey Eyes. Byron H. Li, S.
Yacoub, R. Daly, S. S. Webb, B. Thomas, Q.
Sessums, G. Jernigan, T. Krause, G. Prasanna, D.
S. Rice. Glaucoma Research, Novartis Institutes for
Biomedical Research, Fort Worth, TX *CR
2896 — B0294 Comparative IOP lowering
in a 7-day repeated dose study of latanoprost,
travoprost, bimatoprost, tafluprost, and ONO9054 in normotensive Monkeys. Shinsaku
Yamane, T. Karakawa, K. Moriyuki, M. Sugitani,
Y. Hirota. Department of Biology & Pharmacology,
Ono Pharmaceutical Co., Ltd., Mishima-Gun,
Japan *CR
2897 — B0295 Melatonin, IIK7 and 5-MCANAT potentiate adrenergic receptor-mediated
ocular hypotensive effects in rabbits: significance
for combination therapy in glaucoma. Alejandro
Martínez-Águila, A. Crooke, F. Huete-Toral, A.
Martin-Gil, B. Fonseca, J. Pintor. Biochemistry and
Molecular Biology IV, Complutense University,
Madrid, Spain
2898 — B0296 Oxygen Levels and Distribution
in Rhesus Monkeys: Association with Intraocular
Pressure and Aqueous Outflow Facility. Carla
J. Siegfried1, Y. Shui1, F. Bai1, D. C. Beebe1, 2, G.
A. Heatley3, T. Nork3, B. Tian3, J. McDonald3,
J. A. Kiland3, P. L. Kaufman3. 1Department of
Ophthalmology and Visual Sciences, Washington
University, St Louis, MO;2Department of Cell
Biology and Physiology, Washington University,
St. Louis, MO; 3Department of Ophthalmology and
Visual Sciences, University of Wisconsin, Madison,
WI *CR
2899 — B0297 Effect of ONO-9054 on Aqueous
Humor Dynamics in Monkeys. Tomohiro
Karakawa, S. Yamane, Y. Goto, M. Sugitani, Y.
Hirota. Department of Biology & Pharmacology,
Ono Pharmaceutical Co., Ltd., Mishima-Gun,
Japan *CR
2900 — B0298 Effect of AR-13324 on episcleral
venous pressure (EVP) in Dutch Belted rabbits.
Jeffrey W. Kiel1, C. Kopczynski2. 1Ophthalmology,
Univ of Texas Hlth Sci Ctr SA, San Antonio,
TX; 2Aerie Pharmaceuticals, Inc., Research Triangle
Park, NC *CR
2901 — B0299 Type of Anesthesia Affects
Aqueous Flow and Efficacy of Aqueous Flow
Suppressants in the Mouse. Carol B. Toris1, S.
Fan1, C. L. Hays1, B. M. Ishimoto2.1Ophthalmology,
Univ of Nebraska Medical Ctr, Omaha,
NE; 2Ocumetrics, Mountain View, CA *CR
211
Tuesday Posters
8:30 am – 10:15 am
Moderators: Oscar A. Candia and
Carla J. Siegfried
2887 — B0285 Mechanical and cytokine
stimulation of smooth muscle actin expression
in human trabecular meshwork cells. Jin Liang,
I. D. Navarro, P. Gonzalez, F. Yuan, W. Stamer.
Ophthalmology, Duke University, Durham, NC
Tuesday Posters
8:30 am – 10:15 am
2902 — B0300 Visualization of Aqueous
Humor Dynamics upon Chronic Ocular
Hypertension and Hypotensive Drug Treatment
using Gadolinium-enhanced MRI. Leon
C. Ho1, 2, I. P. Conner3, C. Do4, S. Kim1, 5, E.
X. Wu2, G. Wollstein3, J. S. Schuman3, K. C.
Chan1, 3. 1Neuroimaging Laboratory, Department
of Radiology, University of Pittsburgh, Pittsburgh,
PA;2Department of Electrical and Electronic
Engineering, The University of Hong Kong, Hong
Kong, China; 3Department of Ophthalmology,
University of Pittsburgh, Pittsburgh, PA; 4School of
Optometry, The Hong Kong Polytechnic University,
Hong Kong, China; 5Center for Neuroscience
Imaging Research, Institute for Basic Science
(IBS), Dept. of Biological Science, SKKU, Suwon,
2903 — B0301 Physiological Temperature
Oscillations Alter Matrix Metalloproteinase
MMP-2,9 Secretion by TM5 Human Trabecular
Meshwork Cells Independent of Clock
Genes Per2 and Cry2. Stanley K. Li1, 2, J.
Banerjee1, C. Jang3, A. Sehgal3, R. A. Stone4, M.
Civan1, 5. 1Physiology, University of Pennsylvania,
Philadelphia, PA; 2School of Optometry, Hong
Kong Polytechnic University, Hong Kong, Hong
Kong; 3Neuroscience, University of Pennsylvania,
Philadelphia, PA; 4Ophthalmology, University
of Pennsylvania, Philadelphia, PA;5Medicine,
University of Pennsylvania, Philadelphia, PA
2904 — B0302 Importin-2 and RAN GTP
control nuclear import of glucocorticoid
alpha (GRα) receptor following DEX
treatment in human trabecular meshwork
cell-line (NTM5). Adnan Dibas1, A. F. Clark3,
2
, T. Yorio1, 2. 1Pharmacology & Neuroscience,
University of North Texas Hlth Sci Ctr, Fort Worth,
TX; 2North Texas Eye Research Institute, Fort
Worth, TX; 3Cell Biology and Anatomy, University
of North Texas Health Science Center at Fort Worth,
Fort Worth, TX
2905 — B0303 Cell culture of trabecular
meshwork cells under continuous oxidative stress
by photocatalytic generation of H2O2. Shaun
P. Garland1, J. Morgan2, C. J. Murphy2, 3, P.
Russell2. 1Biomedical Engineering, University
of California, Davis, Davis, CA; 2Department
of Surgical & Radiological Sciences, School of
Veterinary Medicine, University of California,
Davis, Davis, CA; 3Department of Ophthalmology
& Vision Sciences, School of Medicine, University
of California, Davis, Davis, CA *CR
2906 — B0304 Myocilin Mutations Alter GPCR
Endocytosis. Trent J. Bowen1, N. R. Congrove1,
W. Stamer2, B. S. McKay1. 1Ophthalmology and
Vision Science, University of Arizona College of
Medicine, Tucson, AZ; 2Ophthlamology, Duke
University, Durham, NC
2907 — B0305 Strain Survey of Aqueous
Humor Dynamics in the Mouse. J Cameron
Millar1, 2, I. Pang2, 3, A. F. Clark1, 2. 1Cell Biology
and Immunology, University of North Texas Health
Science Center, Fort Worth, TX; 2North Texas Eye
Research Institute, University of North Texas Health
Science Center, Fort Worth, TX; 3Department of
Pharmaceutical Sciences, University of North Texas
Health Science Center, Fort Worth, TX
2908 — B0306 Sphingosine-1-Phosphate
(S1P) Decreases Outflow Facility by Reducing
Effective Filtration Area for Aqueous Humor
Outflow in Bovine Eyes. Laiyin Ma, E. D. Cha, H.
Gong. Ophthalmology, Boston University School of
Medicine, Boston, MA
2909 — B0307 Role of Vascular Endothelial
Growth Factor (VEGF) in the regulation of
conventional outflow facility in mice. Ester
Reina-Torres1, J. M. Sherwood1, W. Stamer2, D.
R. Overby1. 1Bioengineering, Imperial College
London, London, United Kingdom; 2Department of
2910 — B0308 Role of VEGF in Conventional
Outflow Homeostasis. Katy C. Liu1, G. Li2, D.
R. Overby3, W. Stamer2. 1University of North
Carolina at Chapel Hill School of Medicine,
Chapel Hill, NC; 2Department of Ophthalmology,
Duke University, Durham, NC; 3Department of
Bioengineering, Imperial College London, London,
United Kingdom
2911 — B0309 Repeatability of Episcleral
Venous Pressure Measurement. Arash Kazemi, J.
W. McLaren, A. J. Sit. Ophthalmology, Mayo Clinic
Rochester MN, Rochester, MN *CR
2912 — B0310 Automated Assessment
of Episcleral Venous Pressure during
Venomanometry. Jay W. McLaren, A. J. Sit.
Ophthalmology, Mayo Clinic, Rochester, MN *CR
2913 — B0311 Pressure Difference between
the Anterior Chamber and the Vitreous Cavity
in Eyes with Pupillary Block. Sun Ho Park, Y.
Kim, K. Choi. Department of Ophthalmology,
Soonchunhyang University College of Medicine,
Soonchunhyang University Seoul Hospital, Seoul,
Republic of Korea
2914 — B0312 Biophysical properties of
aqueous humor in patients suffering from
glaucoma and cataract. Javier Cabrerizo1,
J. J. Urcola1, G. Saracibar1, C. Dalmasso1, E.
Vecino2. 1Ophthalmology, University Hospital of
Araba, Vitoria-Gasteiz, Spain; 2Universidad del Pais
Vasco, Bilbao, Spain *CR
2916 — B0314 Six months study on signs and
symptoms of polyquad preserved travoprost/
timolol fixed combination on previously treated
glaucoma patients. Teresa Rolle1, R. R. Penna1, L.
Dallorto1, F. Campana2, L. Scudeller3, S. Lanteri4,
G. C. Rossi4. 1Department of Surgical Sciences- Eye
Clinic, University of Torino, Torino, Italy; 2Unità
Complessa di Oculistica, Presidio Ospedaliero S.
Croce e Carle, Cuneo, Italy; 3IRCCS Policlinico
San Matteo, Clinical Epidemiology and Biometric
Unit, Scientific Direction, Pavia, Italy; 4IRCCS
Policlinico San Matteo-Eye Clinic, University of
Pavia, Pavia, Italy *CR
Exhibit/Poster Hall SA C0001-C0033
Tuesday, May 06, 2014 8:30 AM-10:15 AM
Glaucoma
320 Blood flow
Moderators: Alon Harris and Ali S. Hafez
2917 — C0001 The role of systemic arterial
stiffness in open-angle glaucoma with/without
diabetes mellitus. Seong Hee Shim, Y. Kim, J. Bae,
J. Kim. Ophthalmology, Sungkyunkwan University
School of Medicine, Kangbuk Samsung Hospital,
Seoul, Republic of Korea
2918 — C0002 Thigh cuff induced dynamic
blood flow autoregulation in the optic nerve head
of normal healthy human subjects. Grant Cull, L.
Wang, S. Thompson. Devers Eye Institute, Portland,
OR
2919 — C0003 The relationship between
the choroidal thickness and the variability of
ambulatory blood pressure in normal subjects
and open angle glaucoma patients. Sae Heun
Rho1, H. Seo1, S. Rho2. 1Ophthalmology, Dong-A
University Hospital, Busan, Republic of Korea;
2
Ophthalmology, CHA Bundang Medical Center,
CHA University, Seongnam, Republic of Korea
2920 — C0004 Baseline ophthalmic artery
blood flow velocities predict structural
and functional glaucoma progression after
four years. Austin L. Gerber1, A. Harris1, A.
Amireskandari1, G. Eckert2, D. WuDunn1, J.
Abrams1, I. Januleviciene3, M. A. Muchnik1, B.
A. Siesky1. 1Ophthalmology, Indiana Univ School
of Med, South Bend, MI; 2Biostatistics, Indiana
University School of Medicine, Indianapolis,
IN; 3Ophthalmology, Lithuanian University of
Health Sciences, Kaunas, Lithuania *CR
2915 — B0313 Dynamic alterations in
conventional outflow function in Bmp2-induced
ocular hypertensive mice. Guorong Li, P.
Gonzalez, S. Farsiu, W. Stamer. Ophthalmology,
Duke University, Durham, NC
212
2921 — C0005 Changes of peripapillary
retina and retinal nerve fiber layer thicknesss in
diabetic macular edema patients who response
to single intravitreal anti-VEGF injection. SUJIN
KIM1, M. Yeom1, S. Lee2, C. Kim2, S. Lee2,
J. Lee3. 1Department of Ophthalmology,
Maryknoll Medical Center, BUSAN, Republic of
Korea; 2Department of Ophthalmology, College of
Medicine, Kosin University, BUSAN, Republic of
Korea; 3Department of Ophthalmology, College
of Medicine, Pusan National University, BUSAN,
Republic of Korea
2922 — C0006 Retrobulbar and retinal
capillary blood flow predict glaucomatous
structural progression in patients with diabetes.
Annahita Amireskandari1, A. Harris1, B. A.
Siesky1, G. Eckert2, J. Park1, I. Januleviciene3,
D. WuDunn1. 1Ophthalmology, Indiana
IN; 2Biostatistics, Indiana University School of
Medicine, Indianapolis, IN; 3Ophthalmology,
Lithuanian University of Health Sciences, Kaunas,
Lithuania *CR
2924 — C0008 Is Retinal Oxygen Saturation
Related to Retinal Nerve Fiber Layer Thickness
in Glaucoma Patients? Martin Hammer1, 2, L.
Ramm1, S. Peters1, L. Sauer1, R. Augsten1. 1Dept
of Ophthalmology, Universityhospital Jena, Jena,
Germany; 2Center for Biomedical Optics and
Photonics, Univ. of Jena, Jena, Germany *CR
2925 — C0009 Retinal Oxygen Saturation
during 100% Oxygen breathing in Healthy
Subjects and Glaucoma Patients. Olof
B. Olafsdottir1, T. S. Eliasdottir1, 2, J. V.
Kristjansdottir1, 2, S. H. Hardarson1, E.
Stefansson1, 2. 1Ophthalmology, University of
Iceland, Reykjavik, Iceland; 2Ophthalmology,
Landspitali - The National University Hospital,
Reykjavik, Iceland *CR
2926 — C0010 Comparison of retinal
oxygenation and vasculature, retinal nerve
fiber layer and visual field defects in different
subtypes of glaucoma. Yi Fang Lee4, 1, C.
Ong1, 3, Z. Yap1, C. Cheng2, A. Mohla1, M.
E. Nongpiur3, S. Perera1. 1Ophthalmology,
Singapore National Eye Centre, Singapore,
Singapore; 2Ophthalmology, Tan Tock Seng
Hospital, Singapore, Singapore; 3Ophthalmology,
Singapore Eye Research Institute, Singapore,
Singapore; 4Ophthalmology, Changi General
Hospital, Singapore, Singapore
2927 — C0011 Nitric oxide isoforms and their
effect on ophthalmic artery responses and the
survival of retinal neurons. Panagiotis Laspas, E.
Goloborodko, C. Manicam, N. Pfeiffer, A. Gericke.
Ophthalmology Department, University Medical
Center, Mainz, Germany
2934 — C0018 Retrobulbar blood flow
in glaucoma patients with and without
diabetes. Tara Schaab1, A. Harris1, A.
Amireskandari1, G. Eckert2, B. Wirostko3, J. Ling1,
P. Kanakamedala1, B. A. Siesky1. 1Ophthalmology,
Indiana University School of Medicine,
Indianapolis, IN; 2Biostatistics, Indiana
IN;3Ophthalmology, University of Utah, Salt Lake
City, UT *CR
2929 — C0013 Longitudinal changes in retinal
capillary blood flow correlate with changes
in macular thickness in glaucoma patients of
African descent. Priyanka Kanakamedala1, A.
Harris1, B. A. Siesky1, G. Eckert2, L. Racette1,
M. A. Muchnik1, T. Schaab1, J. Ling1, A.
Amireskandari1. 1Indiana University School of
Medicine, Indianapolis, MI;2Biostatistics, Indiana
IN *CR
2935 — C0019 A Comparison of Short
Posterior Ciliary Arteries in Normal and
Glaucomatous Dogs. Catherine Fick, R. R.
Dubielzig. Pathobiological Sciences, UW School of
Veterinary Medicine, Madison, WI
2930 — C0014 Longitudinal changes in retinal
capillary blood flow in glaucoma patients of
African descent versus European descent
over four years. Joshua Park1, A. Harris1, A.
Amireskandari1, G. Eckert2, L. Racette1, L. A. Tobe1,
P. Kanakamedala1, B. A. Siesky1. 1Ophthalmology,
Indianapolis, IN; 2Biostatistics, Indiana University
School of Medicine, Indianapolis, IN *CR
2931 — C0015 Racial Differences in Ocular
Blood Flow in People with Healthy Eyes. Carine
Olinde, A. Harris, B. A. Siesky, D. WuDunn, J.
Eikenberry, L. A. Tobe, D. Awonusi, I. Altaras, L. C.
Ozobu, L. Racette. Department of Ophthalmology
- Eugene and Marilyn Glick Eye Institute, Indiana
University, Indianapolis, IN *CR
2932 — C0016 Retinal Blood Flow in Patients
with Primary Open Angle Glaucoma and
Optic Disc Hemorrhage. Christopher Hudson1, 2,
N. Espahbodi1, A. M. Shahidi1, 2, F. Yusof2, 3, R.
Cheng1, M. Jong1, G. E. Trope1, Y. M. Buys1, J. G.
Flanagan1, 2. 1Department of Ophthalmology and
Vision Sciences, University of Toronto, Toronto,
ON, Canada; 2School of Optometry & Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 3Department of Optometry and Visual
Science, International Islamic University of
Malaysia, Bandar Indera Mahkota, Malaysia *CR
2933 — C0017 Evaluation of retrobulbar
blood flow velocity using colour Doppler
imaging: influence of different operators and
devices. Alice Chandra Verticchio Vercellin1, 2, G.
Milano1, 2, C. Cutolo1, C. Dellafiore3, 2, M. Lava3, 2, P.
Distante1, S. Lombardo1, 2, S. Lanteri1, 2, C. Tinelli2,
F. Calliada3, 2. 1Eye Clinic, University of Pavia,
Pavia, Italy; 2Fondazione I.R.C.C.S. Policlinico
San Matteo, Pavia, Italy; 3Institute of Radiology,
Fondazione I.R.C.C.S. Policlinico San Matteo,
Pavia, Italy
2936 — C0020 In Topically Treated Glaucoma
Patients the Flicker Response of Retinal
Vessels is More Pronounced than in Control
Subjects. Richard P. Stodtmeister, A. Gedenk, M.
Haustein, E. Spoerl, K. R. Pillunat, L. E. Pillunat,
N. Terai. Ophthalmology, University Hospital Carl
Gustav Carus, Dresden, Germany
2937 — C0021 Internal and External Retinal
Arteriolar Diameter and Retinal Nerve Fiber
Layer Thickness in Patients with Primary OpenAngle Glaucoma. Nausica Ghilardi1, A. Russo1, D.
Rizzoni2, C. Costagliola3, F. Semeraro1. 1Eye Clinic,
University of Brescia, Brescia, Italy; 2Medical
Clinic, University of Brescia, Brescia,
Italy; 3Department of Health Sciences, University of
Molise, Campobasso, Italy
2938 — C0022 Assessment of retinal blood flow
in patients with glaucoma related altitudinal
visual field asymmetry. Ayda M. Shahidi1, 2, C.
Hudson1, 2, S. R. Patel1, D. Huang3, O. Tan3, Y. M.
Buys1, G. E. Trope1, J. G. Flanagan1, 2. 1Department
of Ophthalmology and Vision Sciences, Toronto
Western Reasearch Institute/University Health
Network, Toronto, ON, Canada; 2School of
Optometry and Vision Sciences, University of
Waterloo, Waterloo, ON, Canada; 3Casey Eye
Institute, Oregon Health and Science University,
Portland, OR *CR
2939 — C0023 Changes in retinal
capillary blood flow correlate with changes
in macular thickness in glaucoma patients
with diabetes. Nathaniel McIntyre1, A.
Harris1, A. Amireskandari1, G. Eckert2, D.
WuDunn1, J. Abrams1, Y. Catoira-Boyle1, B. A.
Siesky1. 1Ophthalmology, Indiana University
School of Medicine, Indianapolis, IN; 2Biostatistics,
Indianapolis, IN *CR
2940 — C0024 Retinal capillary dropout
increases over time in open-angle glaucoma
patients with diabetes. Patrick Egan1, A.
Harris1, B. A. Siesky1, G. Eckert2, Y. CatoiraBoyle1, J. Abrams1, I. Januleviciene3, T. Schaab1,
A. Amireskandari1. 1Ophthalmology, Indiana
MI; 2Biostatistics, Indiana University School of
Medicine, Indianapolis, IN; 3Ophthalmology,
Lithuanian University of Health Sciences, Kaunas,
Lithuania *CR
213
Tuesday Posters
8:30 am – 10:15 am
2923 — C0007 The Influence of the Energy
Drinks on the Blood Oxygenation of the Optic
Nerve’s Capillaries. Vasile Diaconu, L. LeNgoc, A. Thuy. Ecole D, University of Montreal,
Montreal, QC, Canada
2928 — C0012 Longitudinal changes in
retrobulbar blood flow are strongly correlated
to changes in optic nerve head morphology
in patients of African descent. Scott Wentz1,
A. Harris1, B. A. Siesky1, G. Eckert2, L.
Racette1, J. Park1, L. A. Tobe1, J. Ling1, A.
Amireskandari1. 1Ophthalmology, Indiana
MI; 2Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
2941 — C0025 Changes in retinal capillary
blood flow correlate with changes in optic nerve
head morphology in glaucoma patients with
diabetes. John Ling1, A. Harris1, B. A. Siesky1,
G. Eckert2, B. Wirostko3, P. Kanakamedala1, T.
Schaab1, A. Amireskandari1. 1Indiana University
School of Medicine, Indianapolis, IN; 2Biostatistics,
Indianapolis, IN; 3Ophthalmology, University of
Utah, Salt Lake City, UT *CR
2948 — C0032 Retinal Blood Flow Response to
Ocular Perfusion Pressure Modification. Joseph
Paul1, J. A. Armitage3, A. Fouras2, C. T. Nguyen1,
A. J. Vingrys1, B. V. Bui1, Z. He1. 1Optometry
and Vision Sciences, The University of
Melbourne, The University of Melbourne,
VIC, Australia; 2Mechanical and Aerospace
Engineering, Monash University, Melbourne, VIC,
Australia; 3Medicine, Deakin University, Warn
Ponds, VIC, Australia
2942 — C0026 Characterize Aquaporin 4
(AQP4) expression within the retrolaminar of
the optic nerve head (ONH) during early and
advanced experimental glaucoma (EG).Simon
Thompson, G. Cull, L. Wang. Devers Eye Institute,
Legacy Health, Portland, OR
2949 — C0033 Non-invasive Cerebrospinal
Fluid Pressure, Ocular Hemodynamic
Parameters and Their Correlation with
Neuroretinal Rim Area in Normal-tension
Glaucoma and Healthy Controls. Lina
Siaudvytyte1, I. Januleviciene1, A. Ragauskas3, L.
Bartusis3, 1, A. Harris2, 1. 1Eye Clinic, Lithuanian
University of Health Sciences, Kaunas,
Lithuania; 2Eugene and Marilyn Glick Eye
Institute, Indiana University School of Medicine,
Indianapolis, IN; 3Telematics Science Laboratory
of Kaunas University of Technology, Kaunas,
Lithuania f
Tuesday Posters
8:30 am – 10:15 am
2943 — C0027 Transfer Function Analysis of
Blood Flow Autoregulation in Humans Optic
Nerve Head. Jintao Yu, L. Wang, S. Thompson,
G. Cull. Devers Eye Institute,Legacy Research
Institute, Portland, OR
2944 — C0028 Ocular blood flow
autoregulation compromised in glaucoma
patients with diabetes. Brent A. Siesky1, A.
Harris1, A. Amireskandari1, O. Tan2, S. R. Sadda3, S.
Srinivas4, D. Huang2. 1Ophthalmology, Indiana Univ
Sch of Medicine, Zionsville, IN; 2Ophthalmology,
Casey Eye Institute, Oregon Health and Science
University, Portland, OR;3Ophthalmology, Doheny
Eye Institute, University of Southern California,
Los Angeles, CA; 4Ophthalmology, Doheny Eye
Institute, Los Angeles, CA *CR
2945 — C0029 Evaluation of the Effect
of Elevated IOP on Retinal Capillary Bed
and Total Retinal Blood Flow in Rats Using
Optical Microangiography. Zhongwei Zhi1, J.
C. Morrison2, W. O. Cepurna2, E. C. Johnson2,
R. K. Wang1, 3. 1Bioengineering, University of
Washington, Seattle, WA; 2Ophthalmology, Casey
Eye Institute-OHSU, Portland, OR;3Ophthalmology,
University of Washington, Seattle, WA *CR
2946 — C0030 Effect of intraocular pressure
and cerebrospinal fluid pressure on retinal
hemodynamics. Lucia Carichino1, G. Guidoboni1, 2,
B. A. Siesky2, A. Amireskandari2, I. Januleviciene3,
A. Harris2. 1Mathematics, Indiana Univ Purdue Univ
Indianapolis, Indianapolis, IN; 2Ophthalmology,
Indiana University Sch of Medicine, Indianapolis,
IN; 3Eye Clinic, Lithuanian University of Health
Sciences, Kaunas, Lithuania *CR
2947 — C0031 Nycthemeral Rhythm of
Bilateral Ocular Perfusion Pressure (OPP)
via 24-hour Telemetry in Nonhuman Primates
(NHP). Kevin J. Byrne, L. A. Hethcox, C. A.
Girkin, J. C. Downs. Ophthalmology, University of
Alabama at Birmingham, Birmingham, AL
Exhibit/Poster Hall SA D0001-D0036
Tuesday, May 06, 2014 8:30 AM-10:15 AM
321 RPE/Retina Cell Biology and
Degeneration, II
Moderator: William C. Gordon
2950 — D0001 Expression of HLA-G in the
retinal pigment epithelial cell line, ARPE-19.
Signe G. Svendsen1, C. Wu2, H. B. Juel1, C. Faber3,
E. D. Carosella2, J. LeMaoult2, M. H. Nissen1. 1Int.
Health, Immunology and Microbiology, University
of Copenhagen, Copenhagen, Denmark; 2HematoImmunology Research, CEA, Hospital Saint Louis,
Paris, France;3Ophthalmology, Glostrup Hospital,
Glostrup, Denmark
2951 — D0002 Oxytocinergic Signaling via
GPCR in a Single HEK293 Cell with Stable
Expression of the Oxytocin Receptor. De-Ann
M. Pillers1, 2, M. Chiu1, P. Halbach1, N. York1, B. R.
Pattnaik1, 3. 1Pediatrics, University of WisconsinMadison, Madison, WI; 2McPherson Eye Research
Institute, University of Wisconsin-Madison,
Madison, WI; 3Ophthalmology & Visual Sciences,
University of Wisconsin-Madison, Madison, WI
2952 — D0003 Increased Wnt Inhibitory
Factor 1 in Light and Oxidative Stress-induced
Retinal Degeneration. Ae Jin Choi1, J. Yoon1,
H. J. Lim2, H. Chung1. 1Ophthalmology, Konkuk
University School of Medicine, Seoul, Republic of
Korea; 2Biomedical Science & Technology, Konkuk
University, Seoul, Republic of Korea
2953 — D0004 Expression of Piwi/piRNA
in human ocular tissues: Role in maintaining
functional integrity of retinal pigment epithelial
cells and implication in proliferative diabetic
retinopathy. Subbulakshmi Chidambaram1, S.
Sivagurunathan1, K. Palanisamy1, S. Natarajan1,
P. Rishi2, J. Arunachalam1. 1Vision Research
Foundation, Chennai, India; 2Medical Research
Foundation, Sankara Nethralaya, Chennai, India
2954 — D0005 Expression of the lactate
receptor Gpr81 in mouse retina and its
regulation in mouse models of hemochromatosis
and diabetes. Vadivel Ganapathy1, P. Arjunan1,
J. Gnana-Prakasam1, S. Ananth1, P. M. Martin1, 2,
S. B. Smith2, 3. 1Biochemistry & Molecular
Biology, Georgia Regents University, Augusta,
GA; 2Ophthalmology, Georgia Regents University,
Augusta, GA; 3Cellular Biology and Anatomy,
Georgia Regents University, Augusta, GA
2955 — D0006 NADPH Oxidase4derived H2O2 Promotes Aberrant Retinal
Neovascularization via Activation of VEGF
Receptor 2 Pathway in Oxygen-induced
Retinopathy.Jingming Li1, 2, J. J. Wang1, 3, S.
X. Zhang1, 3. 1Department of Medicine and
Endocrinology, OUHSC, Oklahoma City,
OK; 2Department of Ophthalmology, Affiliated
Eye Hospital of Nanchang University, Nanchang,
China; 3Departments of Ophthalmology &
Biochemistry, SUNY-Buffalo and SUNY Eye
Institute, Buffalo, NY
2956 — D0007 Absence of the antiinflammatory receptor GPR109A is associated
with compromised outer blood-retinal barrier
integrity. Pamela M. Martin1, 2, D. Gambhir1, W.
Promsote1, R. Veeranan-Karmegam1. 1Biochemistry
and Molecular Biology, Georgia Regents University,
Augusta, GA; 2Ophthalmology, Georgia Regents
University, Augusta, GA
2957 — D0008 Age-dependent increases in
lysosomal pH, lysosomal gene expression and
autofluorescence of mouse RPE cells; parallels
with the ABCA4-/- mice suggest causal factors
in age-dependent pathophysiology. Jason Lim1,
W. Lu1, A. M. Laties2, C. H. Mitchell1, 3. 1Anatomy
and Cell Biology, University of Pennsylvania,
Philadelphia, PA; 2Ophthalmology, University
of Pennsylvania, Philadelphia, PA; 3Physiology,
University of Pennsylvania, Philadelphia, PA
2958 — D0009 Outer retinal parameters
studied with Artificial Intelligence methods
predict teleost predatory behavior. Joaquin
De Juan1, N. Martinez-Ruiz1, J. L. Girela1, B.
Boughlala1, D. Gil2. 1Biotecnologia, University of
Alicante, Alicante, Spain; 2Computer Technology,
University of Alicante, Alicante, Spain
2959 — D0010 Olfactomedin 1 may suppress
APP cleavage through its interaction with
BACE1. Shokichi Takahama, N. Nakaya, S. I.
Tomarev. National Eye Institute / National Institutes
of Health, Bethesda, MD
214
2960 — D0011 Activation of inflammatory
signaling in the T17M RHO mice. Tapasi Rana,
M. S. Gorbatyuk. Vision Sciences, University of
Alabama, Birmingham, AL
2961 — D0012 ARL13b and CCDC41 is a
key molecules for docking and tethering of a
primary ciliary vesicle in human retinal pigment
epithelial cells. Kwangsic Joo1, J. Kim1, S. Lee2,
J. Kim1. 1Graduate school of medical science
and engineering, KAIST, Daejeon, Republic of
Korea; 2Ophthalmology, Incheon Metropolitan
Medical Center, Incheon, Republic of Korea
2962 — D0013 Calcium-Induced Apoptosis in
retinal degeneration of S334terRho and P23H
Rho Rats. Vishal M. Shinde, A. Lenox, M. S.
Gorbatyuk. Vision Science, University of alabama
at Birmingham, Birmingham, AL
2964 — D0015 Role of claudin-19 and
claudin-3 on the barrier function of human
retinal pigment epithelium (RPE). Shaomin
Peng1, 2, P. Y. Zhao1, R. A. Adelman3, L. J.
Rizzolo1. 1Surgery/Ophthalmology, Yale
University, New Haven, CT; 2Ophthalmology, 2nd
Hospital of Harbin Medical University, Harbin,
China; 3Ophthalmology, Yale University, New
Haven, CT
2965 — D0016 Investigation of new receptors
of the scavenger family for the phagocytosis
of spent photoreceptor outer segments by
RPE cells. Quentin Rieu1, 2, J. Chatagnon1, 2, E. F.
Nandrot1, 2. 1Therapeutics, INSERM, U968, UPMC
Univ Paris 06, UMR_S 968, Paris, France; 2CNRS,
UMR_7210, Institut de la Vision, Paris, France
2966 — D0017 Effect Of Low Oxygen Culture
On Secretion Of Trophic And Angiogenic Factors
By RPE Cells. Jean-Michel Bourget1, 2, V. Beaulieu
Leclerc1, 2, O. Rochette-Drouin1, 2, S. Landreville1, 2,
S. Proulx1, 2. 1CUO-Recherche, Centre LOEX de
l’Université Laval, Centre de recherche du CHU de
Québec, axe médecine régénératrice, Québec, QC,
Canada;2Département d’ophtalmologie et d’ORL,
Faculté de médecine, Université Laval, Québec,
QC, Canada
2968 — D0019 Sildenafil Treatment Inhibits
Zebrafish Rod Photoreceptor Outer Segment
Shedding. Leah J. Campbell, A. M. Jensen. Biology
Department, University of Massachusetts Amherst,
Amherst, MA *CR
2969 — D0020 Myocilin is constitutively
released with exosomes from RPE in situ.
Christina Locke1, N. R. Congrove1, W. Stamer2,
B. S. McKay1. 1Ophthalmology and Vision
Science, University of Arizona, Tucson, AZ;
2
2970 — D0021 RPE dedifferentiation can be
inhibited by small molecules. Enrique Salero1,
J. Moroney1, J. L. Goldberg2. 1Ophthalmology,
Bascom Palmer Eye Institute, Miami,
FL; 2Ophthalmology, UC San Diego, Shiley Eye
Center, San Diego, CA
2971 — D0022 Disease-causing mutations
associated with four bestrophinopathies exhibit
disparate effects on the localization, but not
the oligomerization, of Bestrophin-1.Adiv A.
Johnson1, 2, Y. S. Lee2, L. Y. Marmorstein2, A. D.
Marmorstein2. 1Physiological Sciences Graduate
Interdisciplinary Program, University of Arizona,
Tucson, AZ; 2Ophthalmology, Mayo Clinic,
Rochester, MN
2972 — D0023 Isoform Switch of RPGR
During Photoreceptor Development. Xun
Sun1, O. V. Bulgakov1, M. Adamian2, Z. Wu1, T.
Li1. 1Neurobiology, Neurodegeneration & Repair
Laboratory (NNRL), National Eye Institute,
Bethesda, MD; 2The Berman-Gund Laboratory
for the Study of Retinal Degenerations, Harvard
Medical School, Boston, MA
2973 — D0024 Deletion of EFEMP1 is
protective against the development of basal
deposits in mouse eyes. Youwen Zhang1, J.
B. Stanton2, Y. S. Lee1, A. D. Marmorstein1, L.
Marmortein1. 1Ophthalmology, Mayo Clinic,
Rochester, MN; 2Surgery, University of Arizona,
Tucson, AZ
2974 — D0025 Diffusion across and
proteoglycan content in Bruch’s membrane are
altered in mice carrying an Efemp1 mutation.
Samuel D. Cross1, A. Zayas2, J. B. Stanton3, A. D.
Marmorstein1, L. Marmortein1. 1Ophthalmology,
Mayo Clinic, Rochester, MN; 2Pathology and
Laboratory Medicine, Universidad Central Del
Caribe, Bayamón; 3Surgery, University of Arizona,
Tucson, AZ
2975 — D0026 Activation of the TGF-beta
and IGF signaling pathway during retina
regeneration in adult zebrafish. Markus
Tschopp1, 2, C. Tappeiner1, E. Maurer1, K.
Schürch1, P. Sallin3, A. Jazwinska3, V. Enzmann1.
1
Department of Ophthalmology, University
of Bern, Bern, Switzerland; 2Department of
Ophthalmology, University of Basel, Basel,
Switzerland; 3Department of Biology, University of
Fribourg, Fribourg, Switzerland
2976 — D0027 Outer segment targeting
of the CNG Channel in Xenopus rod
photoreceptors. Jillian N. Pearring, V. Y.
Arshavsky. Duke Eye Center, AERI, Duke
2977 — D0028 Apical localization of the
CLC-2 chloride channel in polarized RPE
cells. Guillermo Lehmann-Mantaras1, I. Benedicto1,
E. de la Fuente2, D. Gravotta1, E. RodriguezBoulan1. 1Ophthalmology, Well Cornell Medical
College, New York, NY; 2Facultad de Medicina,
Universidad Catolica del Norte, Coquimbo, Chile
2978 — D0029 miR-302 regulates retinal
epithelial cell fate; New insights into TGFβ
signalling reveal a role for for the polycomb
protein EZH2. Darrell Andrews1, N. Faherty1,
G. Oliverio1, C. J. O’Brien2, G. Cagney1, J.
Crean1. 1School of Biomolecular and Biomedical
Science, University College Dublin, Dublin,
Ireland; 2School of Medicine and Medical Science,
University College Dublin, Dublin, Ireland
2979 — D0030 RPE tight junctions are
regulated by endothelial cells. Ignacio
Benedicto1, 3, G. Lehmann-Mantaras1, 3, S. Rafii2, 4,
E. Rodriguez-Boulan1, 3. 1Ophtalmology, Weill
Cornell Medical College, New York, NY; 2Genetic
Medicine, Weill Cornell Medical College, New
York, NY; 3Margaret Dyson Vision Research
Institute, Weill Cornell Medical College, New York,
NY; 4Ansary Stem Cell Institute, Weill Cornell
Medical College, New York, NY
2980 — D0031 Neuroprotectin D1
is Synthesized during Moderate Light
Preconditioning. Eric J. Knott, W. C. Gordon, N.
G. Bazan. Neuroscience Center, Louisiana State
Univ Hlth Sci Ctr, New Orleans, LA
2981 — D0032 Long term organotypic
culture of the human retina. Arnold Szabo1, A.
Enzsoly2, K. Szabo1, A. Szel1,. Lukáts1. 1Dept.
Human Morphology and Developmental Biology,
Semmelweis University, Budapest, Hungary; 2Dept.
of Ophthalmology, Semmelweis University,
Budapest, Hungary
2982 — D0033 Exogenous COL18A1 Restores
Retinal Function in a Patient Specific Model of
Knobloch Syndrome. Huy V. Nguyen1, Y. Li2, I.
H. Maumenee3, S. H. Tsang4.1Columbia University
College of Physicians and Surgeons, New York,
NY; 2Ophthalmology, Columbia University,
New York, NY; 3Illinois Eye and Ear Infirmary,
University of Illinois at Chicago, Chicago,
NY; 4Pathology and Cell Biology, Columbia
University, New York, NY
215
Tuesday Posters
8:30 am – 10:15 am
2963 — D0014 Mouse Prpf3, 8 and 31 mutants
show altered rhythms of retinal phagocytosis and
adhesion. Deborah Lew1, 2, M. H. Farkas3, K. M.
Bujakowska1, 3, J. Chatagnon1, 2, S. S. Bhattacharya4,
5
, E. Pierce3, E. F. Nandrot1, 2. 1Therapeutics,
INSERM, U968, UPMC Univ Paris 06, UMR_S
968, Paris, France; 2CNRS, UMR_7210, Institut
de la Vision, Paris, France; 3Ophthalmology,
Ocular Genomics Institute, Massachusetts Eye and
Ear Infirmary, Harvard Medical School, Boston,
MA; 4Institute of Ophthalmology, University
College London, London, United Kingdom; 5Centro
Andaluz de Biología Molecular y Medicina
Regenerativa, Andalusian Center of Molecular
Biology and Regenerative Medicine, Sevilla, Spain
2967 — D0018 Three-dimensional analysis
of transparent optic nerves reveals enhanced
regeneration and reduced branching of axons
in EphA4 KO mice after traumatic lesion.
Vincent Pernet, S. Joly, N. Jordi, M. E. Schwab.
Brain Research Institute, ETH/Univ Zurich, Zurich,
Switzerland
2983 — D0034 Functional Investigation of
the Role of Prickle 2 in Retinal Photoreceptors.
Sameila Okpodu1, 2, C. Liu2, H. May-Simera2,
W. Graf1, A. Swaroop2, T. Li2. 1Physiology and
Biophysics, Howard University, Washington,
DC; 2Neurobiology Neurodegeneration & Repair
Laboratory (N-NRL), National Eye Institute/
National Institutes of Health, Bethesda, MD
2984 — D0035 Evaluation of Human
Embryonic Stem Cell-Derived Retina as a
Potential Retinoblastoma Model. Victor Liao, N.
Harutyunyan, J. Aparicio, D. Cobrinik, T. C. Lee.
Opthamology, Children Hospital Los Angeles,
Los Angeles, CA
Tuesday Posters
8:30 am – 10:15 am
2985 — D0036 HO-1 gene therapy for
protection of retinal ganglion cells after optic
nerve crush injury in rat. Ming-Hui Sun1, C. Sun2,
K. Chen1, Y. Tsao3. 1Ophthalmology, Chang Gung
Memorial Hospital -LinKou, Kwei-Shan, Tao-Yuan,
Taiwan; 2opthalmology, Chang Gung Memorial
Hospital, KeeLong, Taiwan; 3ophthalmology,
Mackay Memorial Hospital, Taipei, Taiwan
216
Tuesday – Business Meeting
S 230GH
Tuesday, May 06, 2014 10:15 AM-10:55 AM
323 General Business Meeting
Welcome – ARVO President Justine R. Smith,
FRANZCO, PhD, FARVO
Presentation of ARVO Distinguished Service
Awards – ARVO President Justine R. Smith,
FRANZCO, PhD, FARVO
• Peng Tee Khaw, MD, PhD, FARVO, Immediate Past President
• Anton M. Kolomeyer, MD, PhD, Trustee Members-in-Training
• Jacob Pe’er, MD, FARVO, Vice President
Executive Vice President’s Remarks - ARVO
Executive Vice President Craig E. Crosson, PhD,
FARVO
Presentation of Joanne G. Angle Service Award ARVO Executive Vice President Craig E. Crosson,
PhD, FARVO
• Martine Jager, MD, PhD, FARVO
Tuesday Business
Meeting
10:15 am – 10:55 am
Introduction of Incoming Officers –
ARVO President Justine R. Smith, FRANZCO,
PhD, FARVO
Open Discussion – ARVO President Justine R.
Smith, FRANZCO, PhD, FARVO
Conclude Meeting – ARVO President Justine R.
Smith, FRANZCO, PhD, FARVO
217
S 210DE
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Cornea
324 Keratoconus, biomechanics and
keratoprosthesis
Moderators: Keith M. Meek, Mark R. Wilkins
and Dan Epstein
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
2986 — 11:00 Genomic Deletions of RXRACOL5A1, FAM46A-IBTK, HS3ST3B1-PMP22,
and GRIA4 in Familial Keratoconus Patients.
Yutao Liu1, 2, K. K. Abu-Amero3, Y. Bykhovskaya4,
S. Strickland1, A. Al-Muammar3, X. Li5, J. I.
Rotter5, Y. S. Rabinowitz4, R. R. Allingham2,
M. A. Hauser1, 2. 1Medicine, Duke University
Medical Center, Durham, NC;2Ophthalmology,
Duke University Medical Center, Durham,
NC; 3Ophthalmology, King Saud University,
Riyadh, Saudi Arabia; 4Cornea Eye Institute,
Cedars-Sinai Medical Center, Los Angeles,
CA; 5Institute for Translational Genomics and
Population Sciences, Los Angeles BioMedical
Research Institute, Torrance, CA
2987 — 11:15 Long-term (up to 5 years)
results of corneal cross-linking in children
with progressive keratoconus. Beatrice
E. Frueh1, M. Imesch1, C. Tappeiner1, D.
Epstein2.1Ophthalmology, Univ of Bern Inselspital,
Bern, Switzerland; 2Bernese Research Institute,
Bern, Switzerland
2988 — 11:30 Crosslinking Corneal Collagen
in vivo using Rose Bengal and Green Light. Irene
E. Kochevar1, H. Zhu1, C. Alt1, R. W. Redmond1,
S. Melki2. 1Wellman Center for Photomedicine,
Massachusetts General Hospital, Harvard Medical
School, Boston, MA; 2Boston Eye Group, Boston,
MA *CR
2989 — 11:45 The Effect of Corneal Collagen
Crosslinking on Stromal Transport, Electrical,
and Mechanical Properties. R Glenn Hepfer1,
C. Shi1, G. Waring1, 2, H. Yao1.1Bioengineering,
Clemson University, Charleston,
SC; 2Ophthalmology, Medical University of South
Carolina, Charleston, SC
2990 — 12:00 Adjunctive Collagen
Crosslinking of the Residual Stromal Bed in
LASIK: Finite Element Analysis of Impact on
Refractive Outcome and Surgically Induced
Deformation. Ibrahim Seven1, 2, A. Sinha Roy3, W.
J. Dupps1, 2. 1Ophthalmic Research, Cleveland Clinic
Cole Eye Institute, Cleveland, OH; 2Biomedical
Engineering, Lerner Research Institute, Cleveland,
OH; 3Narayana Netralaya, Bangalore, India *CR
2991 — 12:15 Titanium to enhance
biointegration of the Boston Keratoprosthesis
with corneal tissue: a study in rabbits. Borja
Salvador Culla1, 3, K. Jae Jeong2, H. H. Chiang3,
J. Chodosh1, C. H. Dohlman1, D. S. Kohane3, 4.
1
Cornea - Keratoprosthesis, Massachusetts Eye &
Ear Infirmary, Harvard Medical School, Boston,
MA; 2Chemical Engineering, University of New
Hampshire, Durham, NH; 3Anesthesia - Kohane
Laboratory for Biomaterials and Drug Delivery,
Boston Children’s Hospital, Harvard Medical
School, Boston, MA; 4Langer Laboratory, Koch
Institute, Massachusetts Institute of Technology,
Cambridge, MA
2992 — 12:30 Towards nondestructive
assessment of corneal viscoelasticity by imaging
lamb wave propagation with OCT. Kirill Larin,
M. D. Twa, S. Wang. Kirill Larin, University of
Houston, Houston, TX
S 230A-D
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Retina
325 Early AMD
Moderators: Usha Chakravarthy and
Milam A. Brantley
2993 — 11:00 Effect of Aspirin Use
on Progression of Age-Related Macular
Degeneration in the Age-Related Eye Disease
Study 2 (AREDS2) Participants. Mary E.
Aronow1, M. L. Klein2, T. E. Clemons3, F. L. Ferris1,
E. Agron1, B. A. Blodi4, E. Y. Chew1. 1Division
of Epidemiology and Clinical Applications,
National Eye Institute/National Institutes of
Health, Bethesda, MD; 2Casey Eye Institute,
Portland, OR; 3EMMES Corporation, Rockville,
MD; 4University of Wisconsin, Madison, WI f
2994 — 11:15 Treatment Response to AREDS
Components as a Function of CFH and ARMS2
Risk in Patients with AMD. Carl C. Awh1,
B. Zanke2. 1Tennessee Retina, PC, Nashville,
TN; 2ArcticDX, Toronto, ON, Canada *CR
2995 — 11:30 Intravitreal Autologous
Bone Marrow CD34+ Stem Cell Therapy for
Macular Degenerative Disease--A Pilot Clinical
Trial. Susanna S. Park, G. Bauer, A. Panorgias,
R. J. Zawadzki, M. Abedi, J. S. Werner, J. Nolta.
Ophthalmology & Vision Science, Univ of
California Davis Eye Ctr, Sacramento, CA f
2996 — 11:45 Evaluation of the AdaptDx™
for detection of age-related macular
degeneration. Gregory R. Jackson1, 4, I. U. Scott1,
I. K. Kim2, D. A. Quillen1, A. Iannaccone3, J. G.
Edwards4. 1Ophthalmology, Penn State College
of Medicine, Hershey, PA; 2Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston,
MA; 3Ophthalmology, University of Tennessee
Health Science Center, Memphis, TN; 4MacuLogix,
Hummelstown, PA *CR
2997 — 12:00 Development of a novel
bio-compatible polymer film for use as a
Bruch’s membrane substitute. Gareth Ward1, 2,
H. Thomson1, P. Alexander1, 3, J. Ratnayaka1,
A. Treharne2, G. Attard2, M. Grossel2, A.
Lotery1, 3. 1Clinical and Experimental Sciences,
Faculty of Medicine, University of Southampton,
Southampton, United Kingdom; 2Faculty of
Natural and Environmental Sciences, University of
Southampton, Southampton, United Kingdom; 3Eye
Unit, University Hospital Southampton NHS
Foundation Trust, Southampton, United Kingdom
2998 — 12:15 Morphologic Changes in
the Retinal Periphery in Patients with AgeRelated Macular Disease and Controls.The
Croatian OPERA (Optos PERipheral RetinA)
Study. Vesna Jurisic Friberg2, 1, G. Bencic1, M.
Zoric-Geber1, B. Andrijevic Derk1, T. Knezević4,
Z. Vatavuk1, T. R. Friberg3, 1. 1Ophthalmology,
Kbc Sestre Milosrdnice and the University
of Zagreb, Zagreb, Croatia; 2Ophthalmology,
Children’s Hospital of UPMC, Pittsburgh,
PA; 3Ophthalmology, UPMC Eye Center/University
of Pittsburgh, Pittsburgh, PA; 4Ophthalmology,
Polyclinic Ghetaldus, Zagreb, Croatia *CR
2999 — 12:30 Fundus Autofluorescence in
Monkeys Deficient in Lutein/Zeaxanthin and
Omega-3 Fatty Acids. Laurie Renner1, T. Adevai1,
A. Bemis1, M. Neuringer1, 2, T. J. McGill2. 1Oregon
National Primate Research Center, Oregon Health
& Science University, Beaverton, OR; 2Casey Eye
Institute, Oregon Health & Science University,
Portland, OR
S 230EF
Tuesday, May 06, 2014 11:00 AM-12:45 PM
326 Spatial vision
Moderators: Glen L. McCormack and
Frank Schaeffel
3000 — 11:00 Foveal blue scotoma correlated
with the shape of the foveal pit. Yun Chen1,
W. Lan1, 2, F. Schaeffel1. 1Institute for Opthalmic
Research, University Hospital Tubingen, Tubingen,
Germany; 2Zhongshan Ophthalmic Center, State
Key Laboratory of Ophthalmology, Guangzhou,
China
3001 — 11:15 Brightness in human rod vision
is regulated by neural adaptation to photon
statistics. Michael E. Rudd1, 2, F. Rieke1, 2. 1Howard
Hughes Medical Institute, Seattle, WA; 2Department
of Physiology and Biophysics, University of
Washington, Seattle, WA
3002 — 11:30 Neural Sharpening of Images
Moving in Stereoscopic Depth. Glen L.
McCormack1, J. Van Cura1, P. J. Bex2. 1Vision
Science, New England College of Optometry,
Boston, MA; 2Schepens Eye Research Institute,
Harvard Medical School, Boston, MA
218
3003 — 11:45 Monocular attenuation and
binocular inhibition underlie effects of unilateral
mean luminance on binocular combination. Pan
Zhang1, Q. He1, Z. Lu2, C. Huang1.1Key Laboratory
of Behavioral Science, Institute of Psychology,
Chinese Academy of Sciences, Beijing,
China; 2Laboratory of Brain Processes (LOBES),
Departments of Psychology, The Ohio State
University, The Ohio, OH
3004 — 12:00 Quantify Functional
Impairments in Myopic Vision. Ge Chen1, 2, Z.
Lu3, C. Huang1. 1CAS, Institute of Psychology,
Beijing, China; 2Chinese Academy of Sciences,
Beijing, China; 3Department of Psychology, Ohio
State University, Ohio, OH
3005 — 12:15 Does age-related decline in vision
and hearing result in difficulties separating
visual and auditory signals in time? Yu Man
Chan, M. J. Pianta, A. M. McKendrick. Optometry
and Vision Sciences, University of Melbourne,
Parkville, VIC, Australia
3006 — 12:30 Comparison of reading
performance between three different standmounted visual aids using an artificial macular
scotoma. Carlos Aguilar, E. Castet. LPC, CNRS,
Marseille, France *CR
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Glaucoma
327 Visual fields and visual function
Moderators: Brad Fortune and David P. Crabb
3007 — 11:00 Global Visit Effects In Pointwise
Longitudinal Modeling Of Glaucomatous Visual
Fields. Susan R. Bryan1, 2, K. A. Vermeer1, B.
Li2, P. H. Eilers2, H. G. Lemij3, E. M. Lesaffre2,
4 1
. Rotterdam Ophthalmic Institute, Rotterdam,
Netherlands; 2Department of Biostatistics, Erasmus
Medical Center, Rotterdam, Netherlands;3Glaucoma
Service, Rotterdam Eye Hospital, Rotterdam,
Netherlands; 4L-Biostat, KU Leuven, Leuven,
Belgium *CR
3008 — 11:15 Glaucomatous patterns
of binocular visual field loss identified by
unsupervised machine learning. Christopher
Bowd1, S. Yousefi1, D. Meira-Freitas1, 5, M. H.
Goldbaum1, L. M. Zangwill1, R. N. Weinreb1,
J. M. Liebmann3, 4, C. A. Girkin2, F. A.
Medeiros1. 1Hamilton Glaucoma Center of the
California, San Diego, San Diego, CA; 2Department
of Ophthalmology, University of Alabama,
Birmingham, AL; 3New York University School
of Medicine, New York, NY; 4Department of
Ophthalmology, Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York,
NY; 5Department of Ophthalmology, Federal
University of São Paulo, São Paulo, Brazil *CR,f
3010 — 11:45 Standard or Fast? - Differences
in precision between SITA Standard and SITA
Fast testing algorithms and their utility for
detecting visual field deterioration.Luke J.
Saunders, R. A. Russell, D. P. Crabb. Optometry
and Visual Science, City University London,
3011 — 12:00 The Fast Component of Visual
Field Decay Improves after Trabeculectomy. John
Mark S. de Leon1, N. Abdollahi1, P. Azarbod1, E.
Morales1, F. Yu1, 2, J. Caprioli1.1Ophthalmology,
Jules Stein Eye Institute, UCLA, Los Angeles,
CA; 2Biostatistics and Epidemiology, University of
California, Los Angeles, CA
3012 — 12:15 Are we getting better at detecting
glaucoma before the disease becomes advanced?
An examination of trends in visual field severity
at the time of diagnosis. trishal boodhna, L. J.
Saunders, R. Russel, D. P. Crabb. City University,
London, London, United Kingdom
3013 — 12:30 Comparison of fMRI
measurements in LGN and Primary Visual
Cortex with visual deficits in Glaucoma. Joanne
Powell1, A. Choudhary1, 3, L. Parkes2, S.
Wuerger1. 1University of Liverpool, Liverpool,
United Kingdom; 2University of Manchester,
Manchester, United Kingdom; 3Royal Liverpool
University Hospital., Liverpool, United Kingdom
S 310E-H
Tuesday, May 06, 2014 11:00 AM-12:45 PM
328 Mechanisms in retinal
angiogenesis and retinopathy
3016 — 11:30 Ataxia telangiectasia mutated
(ATM) dysregulation precipitates in diabetic
retinopathy. Ashay D. Bhatwadekar1, 2, M. Korah3,
S. Caballero3, J. Baas1, M. Grant1, 3.1Ophthalmology,
Indiana University, Indianapolis, IN; 2Pharmacology
and Toxicology, Indiana University, Indianapolis,
IN; 3Pharmacology and Therapeutics, University of
Florida, Gainesville, FL
3017 — 11:45 The role of 53bp1 and of
the endothelial DNA repair cascade in the
vasoprolifarative retinopathies. Matina
Economopoulou1, 2, R. Zengler1, 2,
L. E. Pillunat1, A. Nussenzweig3, T.
Chavakis2. 1Ophthalmology, University Clinic
Dresden, Dresden, Germany; 2Institute for clinical
pathobiochemistry, University clinic, TU, Dresden,
Germany; 3Laboratory of Genome Integrity, CCR,
NCI, NIH, Bethesda, MD
3018 — 12:00 Laminin β2 and γ3 chains
regulate microglial activation and the
downstream effects of microglia on retinal
vascular development. Saptarshi Biswas1, 2,
J. Chu1, 2, G. Bachay1, 2, D. D. Hunter1, 2, W. J.
Brunken1, 2. 1Ophthalmology, SUNY Downstate
Medical Center, Brooklyn, NY; 2SUNY Eye
Institute, Brooklyn, NY
3019 — 12:15 Targeting of calcium/calmodulindependent protein kinase II delta and gamma
isoforms inhibits growth factor-induced retinal
angiogenesis in vitro. Sadaf Ashraf, H. McCauley,
A. W. Stitt, G. J. McGeown, T. M. Curtis. Centre for
Experimental Medicine, Queens University Belfast,
Belfast, United Kingdom
3020 — 12:30 Deletion of Thioredoxin
Interacting Protein (TXNIP) Augments
Hyperoxia-induced Vaso-obliteration in Ischemic
Retinopathy. Azza B. El-Remessy1, 2, M. A.
Abdelsaid1, 3, A. Ergul1, 3, S. Matragoon1, 2. 1Clin &
Experimental Therapeutics, University of Georgia,
Augusta, GA; 2Culver VDI, Georgia Regents
University, Augusta, GA; 3Physiology, Georgia
Regents University, Augusta, GA
Moderators: Maria Grant and Azza B. El-Remessy
3014 — 11:00 Changes in retinal vessel
caliber with flicker light stimulation in eyes
with diabetic retinopathy. Laurence S. Lim1, 2, P.
Ong1, E. Tai1, 2, G. C. Cheung1, W. S. Foulds1, T. Y.
Wong1, 2. 1Ophthalmology, Singapore National Eye
Center, Singapore, Singapore; 2Ophthalmology,
Yong Loo Lin School of Medicine, National
University of Singapore, Singapore, Singapore
S 320AB
3015 — 11:15 Amacrine cell-derived VEGF is
required for development and maintenance of
the retinal vasculature in mice. Yoshihiko Usui, T.
Kurihara, P. D. Westenskow, E. Aguilar, L. P. Paris,
S. K. Moreno, C. M. Wittgrove, D. Feitelberg, M.
Friedlander. Cell Biology, The Scripps Research
Institute, San Diego, CA
3021 — 11:00 Nonretrograde Endocannabinoid
Signaling Modulates Retinal Ganglion
Cell Calcium Homeostasis Through The
Trpv1 Cation Channel. Andrew O. Jo1, D.
A. Ryskamp1, 2, S. Redmon1, 2, P. Barabas1,
D. Krizaj1, 2. 1Ophthalmology & Visual
UT;2Interdepartmental Program in Neuroscience,
University of Utah, Salt Lake City, UT
Tuesday, May 06, 2014 11:00 AM-12:45 PM
329 Physiology / Pharmacology
Moderator: Naj Sharif
219
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
S 310A-D
3009 — 11:30 What types of visual field defects
are hazardous for driving? Fiona C. Glen, N. D.
Smith, D. P. Crabb. Optometry and Visual Science,
City University London, London, United Kingdom
3022 — 11:15 Studies on function and
regional distribution of TRPV4 in the porcine
lens. Nicholas A. Delamere, A. Mandal, M.
Shahidullah. Physiology, University of Arizona,
Tucson, AZ
3023 — 11:30 Hydrodynamic and
Morphological Changes in the Aqueous Humor
Outflow Pathway after Y27632 Treatment
in Laser-Induced Hypertensive Monkey
Eyes. Chen-Yuan C. Yang1, 2, C. Chen2, C. B.
Toris3, H. Gong2, 1. 1Anatomy and Neurobiology,
Boston University School of Medicine, Boston,
MA; 2Ophthalmology, Boston University School of
Medicine, Boston, MA; 3Ophthalmology & Visual
Sciences, University of Nebraska Medical Center,
Omaha, NE
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3024 — 11:45 Pharmacological Evidence for
Serotonin-2B Receptor-Mediated Bovine Ciliary
Muscle Contraction. Naj Sharif1, M. KulkarniChitnis2, Y. Njie-Mbye2, S. E. Ohia2.1Pharmaceutical
Research, Alcon Research, Ltd (a Novartis
company), Fort Worth, TX; 2Pharmaceutical
Sciences, Texas Southern University, Houston,
TX *CR
3025 — 12:00 Trabecular meshwork exosomes
enhance cellular collagen uptake. W Michael
Dismuke, W. Stamer. Ophthalmology, Duke
3026 — 12:15 A Renal-Like Organic Anion
Transport System in Ciliary Epithelium. Ryan
Pelis1, M. Coca-Prados2. 1Pharmacology, Dalhousie
University, Halifax, NS, Canada;2Ophthalmology
and Visual Sciences, Yale University, New Haven,
CT
3027 — 12:30 CNP reverses AGE effects
on RPE by Acting Downstream from VEGF
Release. Mohammad Dahrouj, Y. Liu, C. E.
Crosson, Z. Ablonczy. Ophthalmology, Medical
Univ of South Carolina, Charleston, SC *CR
S 320GH
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Biochemistry/Molecular Biology /
Visual Neuroscience
330 Phototransduction
3030 — 11:30 Protecting Cone Photoreceptor
Structure & Function: Age-Related Cone
Degeneration Involves Cone Arrestin (Arr4)
Expression. Cheryl M. Craft1, 2, J. S. Pak1, 2, J. D.
Deming1, 2, L. L. Rife1, 2, B. M. Brown1, 2. 1Mary
D. Allen Laboratory for Vision Research, Doheny
Eye Institute, Los Angeles, CA; 2Departments of
Ophthalmology & Cell & Neurobiology, Keck
School of Medicine of the University of Southern
3031 — 11:45 Inhibition of transducin
GTPase shifts global gene expression in the
mouse retina. Vladlen Z. Slepak1, A. Pronin1, 2, K.
Levay1, Q. Wang1, D. Velmeshev3, M. Faghihi3, A.
Majumder4, K. Boyd4, N. Artemyev4. 1Molecular
and Cellular Pharmacology, University of Miami
Miller School of Medicine, Miami, FL; 2Bascom
Palmer Eye Institute Dept Ophthalmology,
Miami, FL; 3Psychiatry, University of Miami
Miller School of Medicine, Miami, FL; 4Molecular
Physiology and Biophysics, University of Iowa,
Iowa City, IA
3032 — 12:00 Bicarbonate Regulates Cyclic
GMP Synthesis in Retinal Rods and Cones.
Xiao-Hong Wen1, T. Isayama1, A. Pertzev2, R. K.
Sharma2, C. L. Makino1, T. Duda2.1Department
of Ophthalmology, Massachusetts Eye and Ear
Infirmary & Harvard Medical School, Boston, MA;
2
Research Divisions of Biochemistry and Molecular
Biology, The Unit of Regulatory and Molecular
Biology, Salus University, Elkins Park, PA
3033 — 12:15 Zebrafish phosphodiesterase
6: circadian subfunctionalisation of novel
inhibitory subunits. Xesus Abalo, D. Lagman, D.
Larhammar. Neuroscience, Uppsala Universitet,
Uppsala, Sweden
3034 — 12:30 Different Impacts of Visual
Pigment Dephosphorylation by PP2A in Mouse
Rods and Cones. Alexander V. Kolesnikov, V.
J. Kefalov. Ophthalmology and Visual Sciences,
Washington University in St Louis, St Louis, MO
S 330CD
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Anatomy/Pathology
331 Myopia
Moderators: Cheryl M. Craft and
Sergey A. Vishnivetskiy
3028 — 11:00 Rhodopsin binding-induced
conformational changes in arrestin-1. Sergey A.
Vishnivetskiy1, Q. Chen1, M. Kim2, N. Van Eps2, T.
Zhuang1, W. L. Hubbell2, C. R. Sanders1, E. Xu3, V.
V. Gurevich1. 1Pharmacology, Vanderbilt University,
Nashville, TN; 2UCLA, Los Angeles, CA; 3Van
Andel Institute, Grand Rapids, MI
3029 — 11:15 Self-association does not play a
decisive role in the distribution of arrestin-1 in
dark-adapted rods. Vsevolod V. Gurevich, S. A.
Vishnivetskiy, S. Kook, E. Gurevich. Pharmacology,
Vanderbilt University, Nashville, TN
Moderators: Alexandra Benavente-Perez and
Ravi Metlapally
3036 — 11:15 The role of cell-cell coupling
in myopia development and light adaptation.
Michelle Teves1, Q. Shi2, W. K. Stell3, D. Eng1. 1B.
Sc. Neuroscience Program, University of Calgary,
Calgary, AB, Canada; 2Graduate Neuroscience
Program, University of Calgary, Calgary, AB,
Canada; 3Cell Biology and Anatomy, and Hotchkiss
Brain Institute, University of Calgary, Calgary, AB,
Canada
3037 — 11:30 Differential gene expression in
tree shrew retina compared with retinal pigment
epithelium (RPE) in response to six hours of
minus-lens wear. Li He, M. R. Frost, T. T. Norton.
Department of Vision Sciences, University of
3038 — 11:45 C57BL/6 mouse eyes treated by
dopamine D1 receptor agonist and antagonist
during form deprivation: an opposite effect
on axial length and refractive development.
Xiangtian Zhou, W. Xiong, F. Huang, J. Yang, J.
Qu. School of Ophthalmology and Optometry,
Wenzhou Medical College, Wenzhou, Zhejiang,
China
3039 — 12:00 Outdoor Exposure Does Not
Inhibit Experimental Myopia. Richard A.
Stone1, Y. Cohen1, A. M. McGlinn1, S. Davison2,
S. Casavant2, J. Huang1, T. S. Khurana3, M.
T. Pardue4, 5, P. M. Iuvone4. 1Ophthalmology,
Univ of Pennsylvania School of Medicine,
Philadelphia, PA; 2Laboratory of Avian Medicine
and Pathology, New Bolton Center, Kennett Square,
PA; 3Physiology, Univ of Pennsylvania School
of Medicine, Philadelph1a, PA; 4Ophthalmology,
Emory University School of Medicine, Atlanta,
GA; 5Rehab R&D Center of Excellence, Atlanta VA
Medical Center, Atlanta, GA
3040 — 12:15 Influence of Oral
7-Methylxanthine on Lens-induced and Form
Deprivation Myopia in Chickens. Kai Wang1, 2,
D. Nava2, K. Trier3, C. Wildsoet2. 1Ophthalmology
Department, Peking University People’s Hospital,
Beijing, China; 2Wildsoet Lab, School of
Optometry, University of California, Berkeley,
Albany, CA; 3Trier Research Laboratories, Hellerup,
Denmark
3041 — 12:30 Changing Material Properties
of the Tree Shrew Sclera during Minus Lens
Compensation and Recovery. Rafael Grytz1,
J. T. Siegwart2, T. T. Norton2. 1Department
of Ophthalmology, University of Alabama at
Birmingham, Birmingham, AL; 2Department
of Vision Sciences, University of Alabama at
Birmingham, Birmingham, AL
3035 — 11:00 Zebrafish as a Model to Study
Emmetropization, Refractive Error, and Retinal
Substructure using Spectral Domain-Optical
Coherence Tomography. Ross F. Collery1,
F. Moehring1, R. F. Cooper3, A. M. Dubis1, J.
Carroll1, 2, B. A. Link1. 1Cell Biology, Neurobiology
and Anatomy, Medical College of Wisconsin,
Milwaukee, WI; 2Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 3Biomedical
Engineering, Marquette University, Milwaukee, WI
220
S 330EF
S 330GH
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Lens
Immunology/Microbiology / Cornea /
332 PCO
Moderators: Linda Musil and Hiroshi Sasaki
3042 — 11:00 The role of fibronectin in
posterior capsular opacification. Mallika Pathania,
Y. Wang, M. K. Duncan. Biological Sciences,
University of Delaware, Newark, DE
3043 — 11:15 Growth factor signaling
and extracellular matrix in lens cell
differentiation. Linda Musil, B. Boswell.
Biochemistry & Molecular Biology, Oregon Health
& Science Univ, Portland, OR
3044 — 11:30 An in vitro evaluation of
the Anew Zephyr™ open bag IOL in the
prevention of PCO using a human capsular
bag model. Michael Wormstone1, J. A. Eldred1,
D. J. Spalton2. 1School of Biological Sciences,
University of East Anglia, Norwich, United
Kingdom; 2King Edward VII Hospital, London,
United Kingdom *CR
3046 — 12:00 Cyclosporine A Induces
Autophagic Cell Death in Lens Epithelial Cells
to Prevent Posterior Capsule Opacification Ex
Vivo. Heather L. Chandler, R. B. Matusow, E.
Curto, K. J. Gervais. The Ohio State University,
Columbus, OH
3047 — 12:15 Vimentin is required for Repair
Function During Wound Healing following Mock
Cataract Surgery. Janice L. Walker1, 2, B. Bleaken1,
L. Zhang1, A. S. Menko1, 2.1Pathology, Anatomy
& Cell Biology, Thomas Jefferson University,
Philadelphia, PA; 2Wills Vision Research Center at
Jefferson, Philadelphia, PA
3048 — 12:30 Mimosine suppresses
proliferation and epithelial mesenchymal
transition in lens epithelial cells. Forum Kayastha,
D. Ganatra, A. Patel, H. Madhu, A. Vasavada. Cell
and Molecular Biology, Iladevi Cataract and IOL
Research Centre, Ahmedabad, India
The mini symposium will discuss the topic of the
microbiome relative to host resistance to ocular
opportunistic pathogens.
Moderators: Michelle C. Callegan and
Robert M. Shanks
3049 — 11:00 Influences of the cytokine
interleukin-22 on the microbiome of mucosal
barriers. Lauren A. Zenewicz. Microbiology &
Immunology, The University of Oklahoma Health
Sciences Center, Oklahoma City, OK
3050 — 11:30 NRLP3 inflammasome
and conjunctival goblet cell control of
bacterial keratitis and conjunctivitis. Darlene
Dartt. 1Schepens Eye Research Institute/
Massachusetts Eye and Ear, Boston,
MA; 2Ophthalmology, Harvard Medical School,
Boston, MA
3051 — 11:50 The microbiome and recurrent
keratitis. Stephen Kaye. Ophthalmology, Royal
Liverpool Univ. Hospital, Liverpool, United
Kingdom
3052 — 12:10 Microbial colonization of
healthy and infected ocular surface. Valery
Shestopalov. 1Ophthalmology, Bascom Palmer Eye
Institute, University of Miami, Miami, FL;2Vavilov
Institute of Genetics, Moscow, Russian Federation
3053 — 12:30 Microbiome in ocular
disease. Michael Zegans. Surgery (Ophthal) &
Microbiology, Dartmouth, Lebanon, NH
S 331A-D
Tuesday, May 06, 2014 11:00 AM-12:45 PM
3056 — 11:30 The effect of macrolide and
tetracycline antibiotics on lipid expression in
human meibomian gland epithelial cells. Yang
Liu, W. R. Kam, J. Ding, D. A. Sullivan. Schepens
Eye Research Institute, Massachusetts Eye and Ear,
3057 — 11:45 Activity of Corneal Cold
Thermoreceptor Nerve Endings Encodes
Tear Fluid Hyperosmolality in Mice. Carlos
Belmonte1, 2, A. Parra2, O. Gonzalez1, 3, J. MerayoLloves1, 3, J. Gallar2. 1Instituto de Oftalmología
Fernández-Vega, Fundacion de Investigación
Oftalmológica, Oviedo, Spain; 2Instituto de
Neurociencias, Univ Miguel Hernandez-CSIC, San
Juan de Alicante, Spain; 3Oftalmología, Universidad
de Oviedo, Oviedo, Spain
3058 — 12:00 L-Carnitine Suppresses the
Production of Pro-inflammatory Cytoiknes
by Preventing the Hyperosmolarity-Induced
Oxidative Stress in Human Corneal Epithelial
Cells. Xia Hua1, 2, R. Deng1, 3, Z. Zhang1, 3, Z. Su1, 3,
L. De-Quan1, S. C. Pflugfelder1. 1Ophthalmology,
Baylor College of Medicine, Houston, TX; 2Tianjin
Eye Hospital, Tianjin, China;3School of Optometry
and Ophthalmology, Wenzhou Medical University,
Wenzhou, China
3059 — 12:15 Stress-Induced Damage to
the Ocular Surface Resembling Dry Eye
can Occur Independently of Chronic T cellmediated Disease. Michael E. Stern1, 4, K. S.
Held1, C. S. Schaumburg1, E. Oh1, S. Ugarte1, L.
A. Wheeler1, M. Calonge2, J. Y. Niederkorn3, S. C.
Pflugfelder4. 1Biological Sciences, Allergan, Inc,
Irvine, CA; 2Ophthalmology, IOBA - University
of Valladolid, Valladolid, Spain; 3Ophthalmology,
UT Southwestern School of Medicine, Dallas,
TX; 4Ophthalomology, Baylor School of Medicine,
Houston, TX *CR
3060 — 12:30 Clusterin (CLU) Prevents Ocular
Surface Damage in a Mouse Model for Human
Dry Eye Disease. M Elizabeth Fini, A. Bauskar,
S. Jeong. USC Institute for Genetic Medicine,
Keck School of Medicine, University of Southern
Cornea
334 Dry Eye Disease
Moderators: David A. Sullivan, Kelly K. Nichols
and Carlos Belmonte
3054 — 11:00 A metabolome-wide study
of dry eye disease. Jelle Vehof1, 2, P. G.
Hysi1, C. J. Hammond1, 3. 1Twin Research &
Genetic Epidemiology, St. Thomas’ Hospital,
King’s College London, London, United
Kingdom; 2Ophthalmology, University Medical
Center Groningen, Groningen, Netherlands;
3
Ophthalmology, St. St. Thomas’ Hospital, King’s
College London, London, United Kingdom
221
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3045 — 11:45 Prevention of secondary cataract
development with photodynamic therapy with
Verteporfin - an in vitro study on human lens
epithelial cells (hLEC’s). Valeska A. Mueller1, 2,
N. W. Schwarz3, 2, S. Albrecht2, M. Hatami2, T.
Skutella2. 1Opthalmology, City Augenarzt, Berlin,
Germany; 2Dept. of Anatomy and Cellbiology,
Ruprecht-Karls-Universität-Heidelberg, Heidelberg,
Germany; 3Opthalmology, Augentagesklinik
Warschauer Str., Berlin, Germany *CR
333 The Microbiome of the Eye
and Beyond - How the Microbiome
Influences Resistance against
Opportunistic Pathogens Minisymposium
3055 — 11:15 Meibomian Gland Dysfunction
Determines the Severity of the Dry Eye
Conditions in Visual Display Terminal
Workers. Huping Wu, Y. Wang, N. Dong. Xiamen
Eye Center, Xiamen, China
3061 — 11:00 Baseline characteristics of over
10,000 patients enrolled into the LUMINOUS
study. Christopher S. Brand. Ophthalmology,
Royal Hallamshire Hospital, Sheffield, United
Kingdom *CR, f
3066 — 12:15 United Kingdom Neovascular
AMD Database study: Time to reactivation
after a pause in treatment - outcomes from
92,000 intravitreal ranibizumab injections.
Pearse A. Keane1, M. McKibbin3, A. Y. Lee1,
U. Chakravarthy2, R. Johnston4, C. A. Egan1, D.
A. Sim1, J. Zarranz-Ventura5, A. Tufail1. 1NIHR
Biomedical Research Centre for Opht, Moorfields
Eye Hospital NHS Foundation Trust, London,
United Kingdom; 2Ctr for Vascular & Vision
Sciences, Queen’s University, Belfast, United
Kingdom; 3Ophthalmology, St. James’s University
Hospital, Leeds, United Kingdom; 4Retinal Service,
Cheltenham General Hospital, Cheltenham, United
Kingdom; 5Retina Service, Bristol Eye Hospital,
Bristol, United Kingdom*CR
3062 — 11:15 Ranibizumab in the real world
clinical setting: results from the one year interim
analysis of the LUMINOUS study. Paul Mitchell.
Ophthalmology, University of Sydney, Sydney,
NSW, Australia *CR, f
3067 — 12:30 The Home Monitoring of the
Eye (HOME) Study: Potential implication
of Findings on Management of Intermediate
AMD Patients. Alexander J. Brucker. Scheie Eye
Institute, Philadelphia, PA f
Hall SB
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Retina
335 Real life management of
retinal disease
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
Moderator: Michael D. Abramoff
3063 — 11:30 Patients undergoing treatment
for wet age-related macular degeneration in one
eye rarely present for an unscheduled emergent
office visit when they develop wet AMD in
their second eye. Sabrina Prabakaran1, 2, S. M.
Cohen1, 2. 1Morsani College of Medicine, USF,
Tampa, FL; 2Retina Vitreous Associates of Florida,
Tampa, FL
3064 — 11:45 Real-world observations of
ranibizumab treatment for neovascular agerelated macular degeneration in patients
from Africa, Asia and the Middle East: Final
results from the UNVEIL study. Naresh
Yadav1, S. diTommaso2, H. Kim3, K. Legodi4,
M. M. Mahgoub5, V. Mester6, E. Wu2. 1Narayana
Nethralaya, Bangalore, India; 2Novartis Pharma
AG, Basel, Switzerland; 3Ophthalmology, Kangnam
Sacred Heart Hospital, Hallym University,
Seoul, Republic of Korea; 4Ophthalmology,
Medforum Medi-clinic, Pretoria, South
Africa;5Ophthalmology, Ain Shams University,
Cairo, Egypt; 6Ophthalmology, Samaya Specialized
Center, Abu Dhabi, United Arab Emirates *CR
3065 — 12:00 Real World Vision Outcomes
in DME Treated with Anti-VEGF Injections
- An Analysis of EMR Data From a Large
Health System. Joanna Campbell1, A. L. Cole7,
A. Almony2, H. Ingraham3, N. M. Holekamp4, 5,
S. Marks3, H. Chandwani1, J. W. Kowalski1, S.
Kiss6. 1GHOSR, Allergan, Irvine, CA; 2Carolina Eye
Associates, Southern Pines, NC;3Ophthalmology,
Geisinger Health System, Danville, PA; 4The
Pepose Vision Institute, Chesterfield,
MO; 5Ophthalmology, Washington University
School of Medicine, St Louis, MO;6Ophthalmology,
Weill Cornell Medical College, New York,
NY; 7CHDA, Allergan, Irvine, CA *CR
222
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Anatomy/Pathology / Retinal Cell Biology /
Retina
336 Non-melanoma intraocular lesions:
Retinoblastoma and beyond
Moderators: Nora V. Laver, Hans E. Grossniklaus
and Rebecca C. Stacy
3068 — A0001 Comparative Analysis Of
ABCG2+ Stem-Like Retinoblastoma Cells
And Induced Pluripotent Stem Cells As ThreeDimensional Aggregates. Gail M. Seigel1, 2, L.
Cassidy1, R. Diaz3, R. Y. Tsai3. 1Center for Hearing
and Deafness, University at Buffalo, Buffalo,
NY; 2SUNY Eye Institute, Buffalo, NY; 3Applied
StemCell, Inc., Menlo Park, CA *CR
3069 — A0002 Optical Coherence Tomography
Enables Imaging of Retinoblastoma Tumor
Initiation in the TAg-RB Mouse Model.
Andrea Wenzel1, 2, M. Shadmand1, 2, T. W.
Corson1, 2. 1Eugene and Marilyn Glick Eye
Institute, Indiana University School of Medicine,
Indianapolis, IN; 2Ophthalmology, Indiana Univ
School of Medicine, Indianapolis, IN *CR
3071 — A0004 Topotecan pharmacokinetics
and safety after super-selective ophthalmic
artery infusion concomitant to melphalan in
children with retinoblastoma. Paula J. Taich1,
A. Ceciliano2, E. Buitrago1, F. Villasante2,
C. Sampor1, G. Mato1, G. L. Chantada1, P.
Schaiquevich1. 1Hospital de Pediatria JP Garrahan,
Buenos Aires, Argentina; 2Maternidad Suizo
Argentina, Argentina, Buenos Aires, Argentina
3072 — A0005 Evaluation of the Efficacy of
Topotecan Loaded Au-Tethered Liposomes and
AU-011 for the Treatment of Retinoblastoma in
vitro. Kristen Jijelava1, S. Kang1, U. Kompella2, S.
A. Durazo2, E. de los Pinos3, J. MacDougall3, H. E.
Grossniklaus1. 1Ophthalmology, Emory University
School of Medicine, Atlanta, GA; 2Pharmaceutical
Sciences, University of Colorado, Denver,
CO; 3Aura Biosciences, Cambridge, MA *CR
3073 — A0006 Small molecules that selectively
inhibit growth of MYCNARB1+/+ retinoblastoma
cells. Kamakshi Sishtla1, 2, T. W. Corson1, 2. 1Eugene
and Marilyn Glick Eye Institute, Indianapolis,
IN; 2Department of Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN
3080 — A0013 Histopathological Analysis of
Cell Division Cycle 25 (CDC25) Phosphatase
Protein in Retinoblastoma. Seema Kashyap1,
L. Singh1, N. Pushker2, S. Sen1, A. Sharma3,
B. Chawla2. 1Ocular Pathology, All India
Institute of Medical Sciences, New Delhi,
India; 2Ophthalmology, Dr. R. P. Centre for
Ophthalmic Sciences, All India INstitute of Medical
Sciences, New Delhi, India; 3Ocular Microbiology,
Dr. R. P. Centre for Ophthalmic Sciences, All India
Institute of Medical Sciences, New Delhi, India
3075 — A0008 Role of HMG protein in
Primary Retinoblastoma. Mithalesh Singh1,
S. Kashyap1, L. Singh1, N. Pushker2, S. Sen1,
A. Sharma3, B. Chawla2. 1Ocular Pathology,
Dr R. P. Centre for Ophthalmic Sciences, All
India Institute of Medical sciences, New Delhi,
India; 2Ophthalmology, Dr R. P. Centre for
Ophthalmic Sciences, All India Institute of Medical
sciences, New Delhi, India; 3Ocular Microbiology,
Dr R. P. Centre for Ophthalmic Sciences, All India
Institute of Medical sciences, New Delhi, India
3081 — A0014 Retinoblastoma (Rb) in Saudi
Arabia- Fifteen Year Retrospective Comparative
Review of a Registry: 1983-1997 vs. 1998-2007
at King Khaled Eye Specialist Hospital. Amir
Pirouzian1, 2, S. Mesfer2, H. Al Katan2, A. M.
Maktabi2, M. Karoui2, N. Asghar2, B. Zaman2, W.
Ahmed2, R. Khandekar2, D. P. Edward1, 2. 1Wilmer
Eye Institute, Johns Hopkins University, Baltimore,
MD; 2Ophthalmology, King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia
3076 — A0009 Ubiquitin carboxyl-terminal
esterase L1 (UCHL1) expression is reduced in
retinoblastoma tumor samples. Patricia SanchezDiaz1, 2, M. Kane1, E. P. Cummings1, J. C. Chang2,
G. E. Tomlinson2, 3, J. Y. Hung2, 3. 1Rosenberg
School of Optometry, University of the Incarnate
Word, San Antonio, TX; 2Greehey Children’s
Cancer Research Institute, University of Texas
Health Science Center at San Antonio, San Antonio,
TX; 3Pediatrics, University of Texas Health Science
Center at San Antonio, San Antonio, TX
3077 — A0010 Analysis of Mitochondrial DNA
Mutations and Altered Protein Expression in
Human Retinoblastoma. Lata Singh1, S. Kashyap1,
N. Saini2, N. Pushker3, S. Sen1, T. C. Nag4, A.
Sharma5, S. Bakhshi6, B. Chawla3, J. Kaur7. 1Ocular
Pathology, All India Institute of Medical Sciences,
New Delhi, India; 2Functional Genomics Unit,
Institute of Genomics and Integrative Biology,
New Delhi, India; 3Ophthalmology, Dr. R. P. Centre
for Ophthalmic Sciences, All India Institute of
Medical Sciences, New Delhi, India; 4Anatomy,
All India Institute of Medical Sciences, New Delhi,
India; 5Ocular Microbiology, Dr. R. P. Centre for
Sciences, New Delhi, India; 6Medical Oncology,
All India Institute of Medical Sciences, New Delhi,
India; 7Ocular Biochemistry, Dr. R. P. Centre for
Sciences, New Delhi, India
3078 — A0011 Review of anatomopathological
features and high-risk factors in 45 primary
enucleated eyes with retinoblastoma. Alexandre
Azevedo, L. Teixeira, J. Soares, C. D. Macedo.
UNIFESP, Sao Paulo, Brazil
3079 — A0012 Histopathologic Grading of
Anaplasia for Retinoblastoma. Pia R. Mendoza1,
G. B. Hubbard1, J. R. Wells1, C. S. Specht2, Q.
Zhang1, H. E. Grossniklaus1.1Ophthalmology,
Emory University, Atlanta, GA; 2Pathology, Penn
State Milton S. Hershey Medical Center, Hershey,
PA
3082 — A0015 Spontaneous Resolution
Of Macular Pucker In Two Patients With
Retinoblastoma. Jelena Potic1, 2, M. Beck Popovic3,
M. Gaillard1, A. Balmer1, F. L. Munier1. 1Hopital
Ophtalmique Jules-Gonin, Lausanne,
Switzerland; 2University of Belgrade, University
Eye Clinic, Clinical Center of Serbia, Belgrade,
Serbia;3Unité d’hémato-oncologie pédiatrique
CHUV, Lausanne, Switzerland
3083 — A0016 Retinal vessel architecture in
retinoblastoma pre and post treatment. Clare
Wilson1, 2, K. Wong3, M. S. Sagoo3, M.
Reddy3. 1Ophthalmology Department, Great
Ormond Street Hospital, London, United
Kingdom; 2Department of Vision Science, UCL
Institute of Ophthalmology, London, United
Kingdom; 3Ophthalmology, Barts Health, London,
United Kingdom *CR
3084 — A0017 Primary and Salvage Proton
Radiotherapy for Intraocular Retinoblastoma:
1990 - 2013. Yoshihiro Yonekawa1, S.
M. MacDonald2, J. E. Munzenrider2, S.
Mukai1.1Ophthalmology, Massachusetts Eye and
Ear Infirmary, Boston, MA; 2Radiation Oncology,
Massachusetts General Hospital, Boston, MA
3085 — A0018 Focal treatment of
retinoblastoma tumors with simultaneous
810nm and 532nm lasers. Ashwin Mallipatna, V.
Surendranath. Retinoblastoma Service, Narayana
Nethralaya, Bangalore, India
3086 — A0019 Treatment Patterns and
Survival of Patients with Retinoblastoma: A
Surveillance, Epidemiology, and End Results
Dataset Evaluation. Diana A. Tamboli1, A. D.
Singh2, A. Topham3. 1Ophthalmology, Loyola
University Chicago, Stritch School of Medic,
Maywood, IL; 2Ophthalmology, Cleveland Clinic,
Cleveland, OH; 3Coalition of National Cancer
Cooperative Group Inc., Philidelphia, PA
223
Tuesday Posters
11:00 am – 12:45 pm
3070 — A0003 Lymphocytic microparticles
suppress growth of retinoblastoma. Qian Qiu,
C. Yang, H. Tahiri, C. Gagnon, P. Hardy. Research
Center of CHU Sainte-Justine, University of
Montreal, Montreal, QC, Canada
3074 — A0007 Establishment of a new
retinoblastoma mouse model by intravitreal
injection of human retinoblastoma Y79 cells
into nude mice eyes - Comparison of SLO/
OCT vs. histological follow up. Alexander V.
Tschulakow1, H. Rodemann2, U. Schraermeyer1, 3,
S. Julien1, 3. 1section of experimental vitreoretinal
surgery, institute for ophtalmic research, Tuebingen,
Germany; 2Department of Radiation Oncology,
Tuebingen, Germany; 3STZ OcuTox, Preclinical
Drug Assessment, Hechingen, Germany
3087 — A0020 Clinical Predictors of high risk
pathological features in advanced enucleated
Retinoblastoma. Azza M. Maktabi1, M. Karaoui5,
S. Al-Mesfer2, H. Al Katan1, S. M. Elkhamary3, D.
Edward4. 1Pathology and Laboratory department,
King Khalid Eye Specialist Hospital,KKESH,
Riyadh, Saudi Arabia; 2Oncology Division, King
Khalid Eye Specialist Hospital, Riyadh, Saudi
Arabia; 3Diagnostic Imaging Department, King
Khalid Eye Specialist Hospital, Riyadh, Saudi
Arabia; 4Reasearch Department, King Khalid Eye
specialist Hospital, Riyadh, Saudi Arabia; 5Medicine
and Peadiatric Department, King Khalid Eye
Specialist Hospital, Riyadh, Saudi Arabia
Tuesday Posters
11:00 am – 12:45 pm
3088 — A0021 Long-term outcomes of Group
B eyes in retinoblastoma patients treated with
chemoreduction and low-dose IMRT radiation
therapy as salvage: The Children’s Hospital
Los Angeles Experience. Dagny Zhu2, 1, J. L.
Berry1, 2, R. Jubran1, T. C. Lee1, A. Murphree1, 2, J.
W. Kim1, 2. 1Children’s Hospital Los Angeles, Los
Angeles, CA; 2Keck School of Medicine at the
University of Southern California, Los Angeles, CA
3089 — A0022 Long-Term Outcomes of Group
C Eyes in Retinoblastoma Patients Treated
With Chemoreduction and Low-Dose IMRT
as Salvage. Lilangi Ediriwickrema1, J. L. Berry2,
R. Jubran3, T. C. Lee1, 2, A. Murphree2, J. W.
Kim1, 2. 1Ophthalmology, University of Southern
California, Los Angeles, CA; 2The Vision Center,
Children’s Hospital Los Angeles, Los Angeles,
CA; 3The Children’s Center for Cancer and Blood
Diseases, Children’s Hospital of Los Angeles, Los
Angeles, CA
3090 — A0023 Intraarterial Chemotherapy
(Ophthalmic Artery Chemosurgery) for Group
D Retinoblastoma. Anthony Daniels1, Y. Gobin2, 3,
B. Marr3, J. H. Francis3, S. E. Brodie4, 3, D. H.
Abramson3. 1Divisions of Ocular Oncology and
Retina, Department of Ophthalmology, Vanderbilt
Eye Institute, Nashville, TN; 2Neurosurgery
/ Interventional Radiology, Weill Cornell
Medical College, New York, TN; 3Ophthalmic
Oncology, Memorial Sloan-Kettering, New York,
NY; 4Ophthalmology, Mount Sinai School of
Medicine, New York, NY
3091 — A0024 Efficacy of second-course
ophthalmic artery chemosurgery for
retinoblastoma. Jasmine H. Francis1, Y. P. Gobin2,
B. Marr1, 2, I. Tendler1, 2, S. E. Brodie3, 1, D. H.
Abramson1, 2, I. J. Dunkel1, 2. 1Memorial SloanKettering Cancer Center, New York, NY; 2WeillCornell Medical College, New York Presbyterian,
New York, NY; 3Mount Sinai School of Medicine,
New York, NY
3092 — A0025 Outcome of 20 eyes with
recurrent or refractory retinoblastoma using
selective intra-arterial and/or intravitreal
chemotherapy. Luiz Teixeira1, 3, J. R.
Fonseca2, 3, J. Soares3, C. H. Hashimoto3, C. D.
Macedo3. 1Ophthalmology, Federal University
of São Paulo, Sao Paulo, Brazil; 2Radiology,
Federal University of São Paulo, São Paulo,
Brazil; 3Pediatric Oncology Institute, Federal
University of São Paulo, São Paulo, Brazil
3093 — A0026 Indocyanine green-mediated
Photothrombosis in the treatment of
Vasoproliferative Retinal Tumors: a case series.
Enrico Bertelli, M. Simonazzi. Divisione Oculistica,
Ospedale Centrale Bolzano, Bolzano, Italy
3094 — A0027 Natural History of
Circumscribed Choroidal Hemangiomas.
Angelica G. Ortiz1, M. A. Gonzalez2, J. Harbour2, B.
Ayres2. 1University of Miami, Miami, FL; 2Bascom
Palmer Eye Institute, Miami, FL
3095 — A0028 Utility of wide-field
autofluorescence imaging in screening for new
retinal capillary hemangiomas associated with
von Hippel Lindau disease. Ilya Leskov, S. Mukai.
Massachusetts Eye and Ear Infirmary, Boston, MA
3096 — A0029 Results of Single spot
limited PDT in patients with choroidal
haemangioma. Marilette Stehouwer1, J.
E. Keunen2, R. O. Schlingemann1, F. D.
Verbraak1.1Ophthalmology, AMC, Amsterdam,
Netherlands; 2Ophthalmology, Radboudumc,
Nijmegen, Netherlands
3097 — A0030 Bevacizumab injections in
patients with a choroidal neovascular membrane
secondary to choroidal osteoma. Maria
Pefkianaki1, V. Papastefanou1, 2, R. Andrews1, V.
Cohen1, 2, M. S. Sagoo1, 2. 1Moorfields Eye Hospital,
London, United Kingdom; 2St Bartholomew`s
Hospital, London, United Kingdom
3098 — A0031 En face OCT imaging of
retinal and choroidal tumors. Cinzia Mazzini,
D. Bacherini, A. Giorni, G. Pieretti, U. Menchini.
Department of Surgery and Translational Medicine,
Eye Clinic, University of Florence, Florence, Italy
3099 — A0032 Ciliary Body Melanocytomas:
Ultrasonographic Characteristics and Natural
Course in 10 Cases. Phillip Tenzel, M. A.
Gonzalez, J. Bermudez Magner, J. Harbour. Bascom
3100 — A0033 Autofluorescence Pattern of
Optic Disc Melanocytoma. Panagiotis Salvanos1, 2,
T. P. Utheim3, M. Moe1, 2, R. Bragadottir1, 2, N.
Eide1. 1Department of Ophthalmology, Oslo
University Hospital, Oslo, Norway; 2University
of Oslo, Oslo, Norway; 3Department of Medical
Biochemistry, Oslo University Hospital, Oslo,
Norway
3101 — A0034 Clinical characteristics of
intraocular lymphoma in southern Japan.
Wakako Yoshinaga, K. Nakao, T. Sakamoto.
Ophthalmology, Kagoshima University, Kagoshima
City, Japan
3102 — A0035 Life Expectancy of Patients with
Intraocular Lymphoma after Peripheral Blood
Stem Cell Transplantation. Manfred Zierhut, T.
Bayyoud, B. Sobolewska, C. M. Deuter. Centre
for Ophthalmology, University of Tuebingen,
Tuebingen, Germany
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Neuro-Ophthalmology
337 Eyelids/Ptosis/Oculoplastics
Moderator: Jason Sokol
3103 — A0273 Eyelid Motion Monitor. Adi
Hanuka1, B. Blankrot1, L. Karabchevsky1,
E. Shoshan1, L. Schächter1, W. Hilo2, 3, D.
Briscoe2, 3. 1Electrical engineering, Technion, Haifa,
Israel; 2Ophthalmology, EMEK medical center,
Afula, Israel; 3School of medicine, Technion, Haifa,
Israel *CR
3104 — A0274 Effect of posterior approach
blepharoptosis repair on eyebrow position and
predictability of preoperative phenylephrine
testing. Tal J. Rubinstein, B. R. Costin, M. M.
Choudhary, A. Weber, J. D. Perry. Ophthalmology,
Cleveland Clinic, Cleveland, OH *CR
3105 — A0275 Ptosis from levator dehiscence,
fatty infiltration, and surgical outcomes. Margaret
McGlynn, B. M. Levine, C. Kim, G. J. Lelli. Weill
Cornell Medical College, New York, NY
3106 — A0276 Mitochondrial Myopathy in
Isolated Congenital Ptosis. Megan Xue1, H.
Herce2, 3, E. Paysse2, 3. 1Baylor College of Medicine,
Houston, TX; 2Ophthalmology, Texas Children’s
Hospital, Houston, TX; 3Ophthalmology, Baylor
3107 — A0277 Comparison Between Preand Postoperative Quantitative Analysis of
Graves Upper Eyelid Retraction Using Margin
Reflex Distance and a Digital Eyelid Image
Processing Method. Thiago M. Nogueira1, A.
C. Goncalves1, A. A. Goncalves1, L. D. Silva1,
M. L. Monteiro1, 2. 1Division of Ophthalmology,
University of Sao Paulo Medical School, Sao
Paulo, Brazil; 2Laboratory for Investigation in
Ophthalmology, University of Sao Paulo Medical
School, Sao Paulo, Brazil f
3108 — A0278 Perceived Age of Patients with
Eyelid Ptosis. Srinivas Sai A. Kondapalli1, C.
Czyz2, 3, J. Foster2, 3, K. Cahill2, 3. 1Ophthalmology,
Loyola University Health System, Maywood,
IL; 2Ophthalmology, Grant Medical Center,
Columbus, OH; 3Section of Oculofacial Plastic
and Reconstructive Surgery, Ohio University/
OhioHealth, Columbus, OH
3109 — A0279 Use of a modified tarsal transfer
for patients with moderate ptosis and lid
retraction. Priya Sahu, S. C. Dresner. Eyesthetica,
Los Angeles, CA
3110 — A0280 Comparing dose and
duration of onabotulinumtoxinA and
incobotulinumtoxinA in blepharospasm and
hemifacial spasm. Joseph Giacometti, M. T. Yen.
Department of Ophthalmology, Cullen Eye Institute,
Baylor College of Medicine, Houston, TX *CR
224
3111 — A0281 Effect of ConjunctivalMüllerectomy with or without Tarsectomy for
Blepharoptosis Repair on Eyelid Contour. Maria
M. Choudhary, T. J. Rubinstein, B. R. Costin,
J. D. Perry. Ophthalmology, Cole Eye Institute,
Cleveland, OH
3112 — A0282 Frequency of and factors
associated with conversion from temporary to
permanent tarsorrhaphy. Larissa Ghadiali1, G. J.
Lelli2. 1Ophthalmology, New York Medical College,
Valhalla, NY; 2Ophthalmology, Weill Cornell
Medical College, New York, NY
3120 — A0290 Tangent visual fields are an
efficient and sensitive method for detecting
the loss of superior visual field caused by
blepharoptosis and dermatochalasis. Molly
L. Fuller1, 2, C. A. Briceño2, E. A. Bradley1, C.
Nelson2. 1Ophthalmology, Mayo Clinic, Rochester,
MN; 2Ophthalmology, Kellogg Eye Center,
University of Michigan, Ann Arbor, MI
Tuesday, May 06, 2014 11:00 AM-12:45 PM
3113 — A0283 A new coagulation treatment
paradigm for patients having eyelid
surgery. Ameet Goyal, S. L. Goyal, R. Goyal.
Ophthalmology, Rye, NY
Cornea
3114 — A0284 Large chalazia affecting
multiple eyelids associated with bortezomib.
Seanna Grob1, 3, F. Jakobiec2, 3, A. Rashid2, 3,
M. K. Yoon1, 3. 1Oculoplastics, Massachusetts
Eye and Ear Infirmary, Boston, MA; 2David
G. Cogan Ophthalmic Pathology Laboratory,
Massachusetts Eye and Ear Infirmary, Boston,
MA; 3Ophthalmology, Harvard Medical School,
Boston, MA
Moderator: Anthony J. Aldave
3116 — A0286 A Tissue Microarray Analysis
of Stem cell markers positive cells in Human
Accessory Lacrimal Glands (ALG) from Muller
Muscle Conjunctival Resection (MMCR)
Specimens. Sarmad H. Jassim, A. Lin, P. Setabutr,
A. H. Jaboori, S. Jain, V. Aakalu. Ophthalmology
and Visual Sciences, University of Illinois at
Chicago, Chicago, IL
3117 — A0287 A Histologic Analysis of Tissue
Excised During Mullerectomy for Blepharoptosis
Repair. Chad S. Marcantonio1, 2, D. Lazar1, 2, A.
B. al-Hariri2, 3. 1Ophthalmology, Louisiana State
University Health Science Center, New Orleans,
LA; 2Ophthalmology, Ochsner, New Orleans,
LA; 3Ophthalmology, Worley & Hariri Oculoplastic
Surgery, New Orleans, LA
3118 — A0288 Systemic absorption of
bevacizumab after subcutaneous eyelid skin
injection: an animal study. Vladimir Kratky, A.
Minuk, C. Law, I. Irrcher. Ophthalmology, Queen›s
University, Kingston, ON, Canada
3119 — A0289 Cytokine Profiles in Clinical
Subtypes of Ophthalmic Graves’ Disease. Jason
Sokol, R. Linquist, T. Whittaker, R. C. Symons.
Ophthalmology, Kansas University Medical Center,
Overland Park, KS
3121 — A0291 Clinical Outcomes of
Phototherapeutic Keratectomy after treatment of
Epithelial Basement Membrane Dystrophy and
Salzmann’s nodular corneal dystrophy.Carson
Lam, E. E. Manche. Ophthalmology, Stanford,
Mountain View, CA
3122 — A0292 Robotic Microsurgery In
Ophtalmology. Mathieu NARDIN, G. Soudier, A.
Heitz, D. Gaucher, C. Speeg-Schatz, T. Bourcier.
NHC, Strasbourg, France
3123 — A0293 The effect of regional limbal
injury on mouse corneal epithelium. Asadolah
Movahedan, N. Afshar, M. Eslani, S. Gidfar, A. R.
Djalilian. Ophthalmology & Visual Sciences, Univ
of Illinois at Chicago, Chicago, IL
3124 — A0294 Laboratory Evaluation of
Feasible Depths for Femtosecond Laser Assisted
Lamellar Anterior Keratoplasty. Maolong Tang,
C. Zhang, M. Bald, Y. Li, D. Huang. Casey Eye
Institute, Oregon Health and Science University,
Portland, OR *CR
3125 — A0295 Femtosecond Laser Zig-Zag
Deep Anterior Lamellar Keratoplasty for the
Treatment of Corneal Stromal Pathology. Kristin
Hirabayashi, M. Farid, M. Wade, S. Garg, R. F.
Steinert. Ophthalmology, University of California,
Irvine, Irvine, CA *CR
3126 — A0296 Femtosecond laser mini-bubble
deep anterior lamellar keratoplasty. Roger
F. Steinert, M. Farid, S. Garg, M. Wade.
Ophthalmology, Gavin Herbert Eye Institute, Irvine,
CA *CR
3130 — A0300 Bowman layer implantation:
an alternative to penetrating or deep anterior
lamellar keratoplasty in eyes with advanced
keratoconus. Jack Parker1, K. van Dijk2, G.
Melles2. 1Ophthalmology, UAB Callahan Eye
Hospital, Birmingham, AL; 2Netherlands Institute
for Innovative Ocular Surgery, Rotterdam,
Netherlands f
3131 — A0301 Surgical experience and
deep anterior lamellar keratoplasty and a
comparison of clinical outcomes following deep
anterior lamellar keratoplasty and penetrating
keratoplasty. Shivani Kasbekar1, 2, S. Ahmad1, 2,
M. N. Jones4, F. Larkin3, S. Kaye2, 1. 1Eye and
Vision science, University of Liverpool, Liverpool,
United Kingdom; 2St Pauls Eye Unit, Royal
Liverpool University Hospital, Liverpool, United
Kingdom; 3Moorfields Eye Hospital, London,
United Kingdom; 4NHS Blood and Transplant,
Bristol, United Kingdom
3132 — A0302 Deep anterior lamellar
keratoplasty versus penetrating keratoplasty in
keratoconus. A single center retrospective study
of 47 cases. Loïc Bourmault, G. Barreau, J. Delmas,
J. Adenis, P. Robert. CHU Dupuytren, LImoges,
France
3133 — A0303 Survival corneal graft rate in
children after Penetrating Keratoplasty. Regina
Velasco, A. Babayan, O. Fernandez, O. Baca, E.
D. Alegria, C. Pacheco Del Valle. Cornea, Hosp de
Nuestra Sra de la Luz, Mexico City, Mexico
3134 — A0304 Systemic cyclosporine treatment
in primary pediatric keratoplasty. Evaluation
of results. Telmo Xabier Lerchundi Plaza1,
A. Ibarrola Vidaurre2, B. Jiménez Gómez1, M.
Sanchez Lopez1, S. De Fernando Aisa1, R. Martinez
Fernandez1, J. A. Duran1, N. Martínez Alday1, J.
Etxebarria1. 1Ophthalmology, Hospital Universitario
Cruces, Cruces/Barakaldo, Spain; 2Pediatrics,
Hospital Universitario Cruces, Cruces/Barakaldo,
Spain
3127 — A0297 Femtosecond Laser Enabled
Penetrating Keratoplasty With Zig-Zag Incision:
Suture-Pattern Comparison and Suture-Out
Results. Matthew Wade, S. Garg, M. Farid, R. F.
Steinert. Gavin Herbert Eye Institute, UC Irvine,
Irvine, CA *CR
3128 — A0298 Femtosecond Corneal Cut
Quality as Function of IOP. Alexander Vankov, P.
Gooding, M. Wiltberger, D. Dewey, N. Bareket, G.
Schuele. Abbott Medical Optics, Inc., Sunnyvale,
CA *CR
225
Tuesday Posters
11:00 am – 12:45 pm
3115 — A0285 Accessory Lacrimal Gland
(ALG) Gene Expression from Human Muller
Muscle Conjunctival Resection (MMCR)
Specimens Obtained via Laser Capture
Microdissection (LCM). Vinay Aakalu, S. H.
Jassim, A. Lin, A. H. Jaboori, P. Setabutr, S. Jain.
Ophthalmology and Visual Sciences, University of
Illinois at Chicago, Chicago, IL
338 Penetrating keratoplasty and other
3129 — A0299 Evaluation of Femtosecond
Laser-assisted Clear Corneal and Paracentesis
Incisions for Cataract Surgery. James E. Hill1,
B. Gray1, L. Huang1, W. F. Wiley2, K. L. Waltz3,
C. Garufis1, L. Connolly1. 1Abbott Medical Optics,
Santa Ana, CA; 2Cleveland Eye Clinic, Cleveland,
OH; 3Eye Surgeons of Indiana, Indianapolis,
IN *CR, f
3135 — A0305 Chronological Characteristic
Analysis of Corneal Transplantations at a
Single Tertiary Referral Hospital. Yongjae
Cha1, 2, H. Choi3, 2, J. Hyon4, Y. Han5, J. Oh1, 2, W.
Wee1, 2, M. Kim1, 2. 1Department of Ophthalmology,
Seoul National University, Seoul, Republic of
Korea; 2Laboratory of Ocular Regenerative
Medicine and Immunology, Artificial Eye
Center, Seoul National University Hospital
Biomedical Research Institute, Seoul, Republic
of Korea; 3Department of Ophthalmology,
Seoul National University Hospital Healthcare
System Gangnam Center, Seoul, Republic of
Korea; 4Department of Ophthalmology, Seoul
National University Bundang Hospital, Seongnam,
Republic of Korea; 5Department of Ophthalmology,
Seoul National University Boramae Hospital, Seoul,
Republic of Korea
Tuesday Posters
11:00 am – 12:45 pm
3136 — A0306 Penetrating Keratoplasty for
Post-LASIK Ectasia. Mikhail Romashko1, G. W.
Zaidman2, 1. 1New York Medical College, Valhalla,
NY; 2Ophthalmology, Westchester Medical Center,
Valhalla, NY
3137 — A0307 Analysis of factors affecting
the graft rejection and graft failure in imported
donor corneas. Soo Jeong Ryu1, 2, Y. Han1, 3,
J. Hyon1, 2. 1Ophthalmology, Seoul National
University College of Medicine, Seoul, Republic
of Korea; 2Ophthalmology, Seoul National
University Bundang Hospital, Seongnam-si,
Gyeonggi-do, Republic of Korea;3Ophthalmology,
Seoul Metropolitan Government-Seoul National
University Boramae Medical Center, Seoul,
Republic of Korea
3138 — A0308 Unknown Active Lyme Disease
in a Corneal Donor: Two Case Reports. Amilia
Schrier1, E. Smith2, S. Burney3, L. H. Suh4,
C. Zaslow1. 1Manhattan Eye Ear and Throat
Hospital - Hofstra University at North Shore LIJ Health System, New York, NM; 2Downstate
Ophthalmology Associates, New York,
NY; 3Kingsbrook Jewish Medical Center, New
York, NY; 4Columbia University, New York, NY
3139 — A0309 Endophthalmitis following
primary penetrating keratoplasty in the
United Kingdom. Jern Yee Chen1, M. N.
Jones2, S. Srinivasan3, J. Armitage5, T. Neal4,
S. Kaye1. 1St. Paul’s Eye Unit, Royal Liverpool
University Hospital, Liverpool, United
Kingdom; 2NHS Blood and Transplant, Bristol,
United Kingdom; 3University Hospital Ayr, Ayr,
United Kingdom; 4Medical Microbiology, Royal
Liverpool University Hospital, Liverpool, United
Kingdom; 5Bristol Eye Bank, University of Bristol,
Bristol, United Kingdom
3140 — A0310 Evaluation of a new protocol
for sterility controls of corneal culture
medium. Henning Thomasen, K. Steuhl, D. Meller.
Department of Ophthalmology, University Hospital
Essen, Essen, Germany *CR
3141 — A0311 Relevance of Sputum
Cultures in Evaluating Donor Corneal Tissue
for Transplant. Will Griffeth1, P. Krall1, M.
Gray1, L. R. Groden2, A. Morganti2, P. Gore2,
M. D. McCartney2, L. Forest-Smith2, A.
Kubal1. 1Ophthalmology, University of Florida,
Gainesville, FL; 2Lions Eye Institute for Transplant
and Research, Tampa, FL
3142 — A0312 Iridocorneal adhesions after
early selective suture removal in combined
penetrating keratoplasty and cataract extraction
with intraocular lens implantation.Veena Mathew,
C. P. Lagler, W. M. Munir. Ophthalmology, Boston
University School of Medicine, Boston, MA
3143 — A0313 Analysis of the changes
in keratoplasty indications. Stefan J. Lang1,
M. Bischoff2, D. Böhringer1, B. Seitz2, T.
Reinhard1. 1Eye Center, Albert-Ludwigs-University
of Freiburg, Freiburg, Germany; 2Department
of ophthalmology, Saarland University Medical
Center, Homburg-Saar, Germany
3144 — A0314 Not-So-Benign Scleral
Plaques: A Case Series. Jing Jing Feng1, C.
Giannikas1, C. Shih1, J. Seedor2, T. Milman2, I. J.
Udell1. 1Ophthalmlogy, North Shore-LIJ Health
System, Great Neck, NY; 2New York Eye and Ear
Infiirmary, New York, NY
3145 — A0315 OCT-Guided, Laser-Assisted
Anterior Lamellar Keratoplasty (LALaK), a
Novel Technique for Lamellar Keratoplasty
in Children with Partial Thickness Corneal
Opacities. Bibiana J. Reiser1, 2, M. Tang3,
D. Huang3. 1Ophthalmology, University of
Southern California, Los Angeles, CA; 2Surgery,
Childrens Hospital of Los Angeles, Los Angeles,
CA;3Ophthalmology, Casey Eye Institute/ Oregon
Health Sciences University, Portland, OR *CR, f
3146 — A0316 Boston type I Keratoprosthesis
assisted with intra-prosthetic amniotic
membrane (AmniotiKPro sandwich
technique). Julio C. Hernandez, A. Navas, J. SernaOjeda, A. J. Ramirez-Miranda, E. O. Graue. Cornea
and Refractive Surgery, Instituto de Oftalmologia
«Conde de Valenciana», Mexico City, Mexico
3147 — A0317 A Novel Murine Model For
Keratoprosthesis Research. Alja Crnej1, M.
Omoto2, T. H. Dohlman2, C. H. Dohlman2, R.
Dana1, 2. 1Cornea Service, Massachusetts Eye
and Ear Infirmary, Boston, MA; 2Schepens Eye
Research Institute, Boston, MA
3148 — A0318 Type I Keratoprosthesis in
Stevens-Johnson Syndrome. Kevin Tozer, S.
I. Mian. Ophthalmology and Visual Sciences,
University of Michigan, Ypsilanti, MI
3150 — A0320 Repeated Penetrating Corneal
Transplantation in an University Hospital. Paulo
Rodolfo T. Barbisan, R. S. Castro. Ophthalmology,
State University of Campinas, Campinas, Brazil
3151 — A0321 Glued On Lamellar
Sclerokeratoplasty For Anterior Surface
Segment Decompensation. Eduardo Arenas. Santa
Fe Foundation, Bogota, Colombia f
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Glaucoma
339 Surgery and wound healing
Moderators: Franz J. Grehn and
David C. Broadway
3152 — A0322 Comparison of Limbus-Based
Vs Fornix-Based Trabeculectomy in Surgical
Success for Open-Angle Glaucoma Eyes With
Prior Ocular Surgery: The Collaborative Blebrelated Infection Incidence and Treatment
Study. Satoshi Yokota1, 2, Y. Takihara1, M.
Inatani1. 1Ophthalmology, Fukui University, Eiheijicho, Japan; 2Ophthalmology, Kyoto University,
Kyoto, Japan
3153 — A0323 Injection of Bevacizumab at
the time of Molteno-3 tube insertion: a pilot
study. Frederick M. Kapetansky. Ophthalmology,
The Ohio State University, Columbus, OH
3154 — A0324 Use of Bevacizumab following
trabeculectomy surgery: A prospective,
randomized, controlled trial. Catherine
M. Birt1, J. Compan1, S. Muhsen2, T. Lai3,
C. Kranemann1. 1Ophthalmology & Vision
Sciences, University of Toronto, Toronto, ON,
Canada; 2Ophthalmology, University of Jordan,
Amman, Jordan; 3Ophthalmology, University of
Western Australia, Perth, WA, Australia f
3155 — A0325 Preoperative intravitreal
bevacizumab on trabeculectomy with mitomycin
C for neovascular glaucoma: prognostic factor
for surgical failure. Kazuyuki Hirooka, T. Baba,
E. Nitta, K. Tenkumo, S. Sato. Ophthalmology,
Kagawa Univ Faculty of Medicine, Kita-gun, Japan
3156 — A0326 Phaconeedling versus
phaco-retrabeculectomy in the treatment of
patients with concomitant cataract and failed
trabeculectomy. Leonardo S. Shigueoka, J. C.
Vasconcellos, V. P. Costa. Glaucoma, University of
Campinas, Campinas, Brazil
3149 — A0319 Tectonic graft using preserved
human scleral tissue for urgent treatment
of perforated cornea due to infectious
keratitis. Hyung-Joon Kim, S. Yoon. Department
of Ophthalmology, Daegu Catholic Univ Hospital,
Daegu, Republic of Korea
226
3157 — A0327 Trabeculectomy with
Mitomycin C: Outcomes and Risk Factors
for Failure in the Collaborative Bleb-related
Infection Incidence and Treatment Study. Yosuke
Sugimoto1, H. Mochizuki1, S. Ohkubo2, T.
Higashide2, K. Sugiyama2, Y. Kiuchi1. 1Department
of Ophthalmology & Visual Science, Hiroshima
University Graduate School of Biomedical
Sciences, Hiroshima, Japan; 2Department of
Ophthalmology & Visual Science, Kanazawa
University Graduate School of Medical Sciences,
Kanazawa, Japan
3158 — A0328 Evaluation of blebs after
glaucoma filtering surgery with en face anterior
segment optical coherence tomography. Lyes
Meziani1, R. Tahiri Joutei Hassani1, M. El
Sanharawi3, E. Brasnu1, 2, H. Liang1, 2, C.
Baudouin1, 2, A. Labbe1, 2. 1Department of
Ophthalmology III, Quinze-Vingts National
Ophthalmology Hospital, Paris, France; 2INSERM
U 968, UMR S 968, CNRS, UMR 7210, 45, Institut
de la Vision, UMPC University Paris 06, Paris,
France; 3Department of Ophthalmology V, QuinzeVingts National Ophthalmology Hospital, Paris,
France *CR
3160 — A0330 Effect of trabeculectomy
and canaloplasty on intraocular pressure
modifications after postural changes in primary
open-angle glaucoma. Ivano Riva1, L. Quaranta1,
E. Biagioli2, C. Tosoni3, P. Brusini3, A. Katsanos4,
I. C. Floriani2, A. Konstas5. 1Center for the Study
of Glaucoma, University of Brescia, Brescia,
Italy; 2Laboratory of Clinical Research, IRCCS
- Istituto di Ricerche Farmacologiche “Mario
Negri”, Milano, Italy; 3Ophthalmology Department,
A.O. San Maria della Misericordia, Udine,
Italy; 4Ophthalmology Department, University of
Ioannina, Ioannina, Greece; 5Glaucoma Unit, 1st
University Department of Ophthalmology, AHEPA
Hospital, Thessaloniki, Greece
3161 — A0331 Effects of Laser Suture Lysis
on the Success of Trabeculectomy. Neerav
Lamba1, H. Logothetis2, 1, T. Patrianakos1,
E. Anderson1. 1Ophthalmology, John H
Stroger Hospital of Cook County, Chicago,
IL; 2Ophthalmology, University of Illinois, Chicago,
IL
3162 — A0332 Trabeculectomy supplemented
with a high dose mitomycin-c for treating
refractory pediatric glaucoma. Jose A. Paczka1, 2,
M. A. Ramos-Hdez1, 2, P. Madrigal-Ruiz1, L. A.
Giorgi-Sandoval2, E. P. Chavez-Cedillo1, 2, C.
L. Soria-Orozco1. 1Oftalmologia, University of
Guadalajara, Guadalajara, Mexico; 2Investigación
clínica, Unidad de Diagnostico Temprano del
Glaucoma, Guadalajara, Mexico
3164 — A0334 Safety and efficacy of the use
of intraoperative injection versus conventional
sponge-applied mitomycin C during
trabeculectomy. Grace Huang2, L. Y. Huang1, A.
S. Khouri1. 1Institute of Ophthalmology and Visual
Science, Rutgers, New Jersey Medical School,
Newark, NJ; 2Rutgers, New Jersey Medical School,
Newark, NJ
3172 — A0342 Success of Intraocular
Pressure Control in Glaucoma Patients
Undergoing Canaloplasty with and without
Cataract Extraction in a Single Center Setting.
Alexandros Pappas1, R. Pappas2, A. Rhodes2. 1Nova
Southeastern University College Of Osteopathic
Medicine, Davie, FL; 2Pinnacle Eye Center,
Melbourne, FL
3173 — A0343 Impact of laser trabeculoplasty
and cataract surgery on ab interno
trabeculectomy (Trabectome) outcomes.
Samantha XY Wang, P. Phuchantuk, S. Kavoussi,
R. A. Adelman, J. C. Tsai, T. M. Grippo, J. Liu. Yale
University School of Medicine, New Haven, CT
3165 — A0335 Outcomes of Combined
subconjunctival with subscleral Ologen implant
in glaucoma filtering surgery. Dewang Angmo,
R. Falera, A. Singh, G. Sinha, B. Patil, T. Dada.
Ophthalmology, Dr RP Centre for Ophthalmic
Sciences, AIIMS, New Delhi, India
3174 — A0344 Factors Associated with
Successful Outcomes in Trabectome Only
Surgery. Constance Okeke3, E. G. Miller-Ellis1, N.
A. Loewen2. 1Scheie Eye Institute, Philadelphia,
PA; 2UPMC Eye Center, Pittsburgh, PA; 3Virginia
Eye Consultants, Norfolk, VA *CR
3166 — A0336 Deep Sclerectomy
versus Trabeculectomy in eyes with
Keratoplasty. Patrick Loriaut, J. Nordmann, L.
Laroche, V. M. Borderie. Ophthalmology, CHNO
Quinze-Vingts, Paris, France
3175 — A0345 Update on Outcomes of
Trabectome. Don Minckler. University of
California, Irvine, Irvine, CA *CR
3167 — A0337 Outcomes of Trabeculectomy
with Adjunctive Mitomycin-C Performed by
Resident Surgeons at a County Hospital. Gagan
K. Sawhney, P. Khator, A. D. Beck. Ophthalmology,
Emory University School of Medicine, Atlanta, GA
3168 — A0338 The Ex-PRESS glaucoma shunt
versus trabeculectomy in open-angle glaucoma in
Mexican patients. Natalie Juárez Reyna, A. Fabre
Miranda, L. Zarate, M. García-Huerta, R. Castaneda
Diez, M. Turati Acosta, J. Jimenez-Roman.
Glaucoma, Asociación Para Evitar la Ceguera en
México, DF, Mexico
3169 — A0339 Investigation of Ex-PRESS
Device placement after Ex-PRESS Glaucoma
Filtration Device Surgery using Anterior
Segment Optical Coherence Tomography.
Hirofumi Uyama1, 2, T. Kameda1, 2, Y. Hirami1, 2,
F. Hirose1, 2, A. Nishida1, 2, K. Ishida1, 2, Y.
Kurimoto1, 2. 1Opthalmology, Kobe city
Medical center General Hospital, Kobe,
Japan;2Opthalmology, Institute of Biomedical
Research and Innovation, Kobe, Japan
3170 — A0340 Long term outcomes of ExPRESS glaucoma filtration surgery in African
American patients with glaucoma. Ann M.
John, T. L. Berezina, R. D. Fechtner, A. S. Khouri.
Ophthalmology, Rutgers New Jersey Medical
School, Newark, NJ *CR
3171 — A0341 Trabeculectomy versus ExPRESS™: 3 year-follow up. Graham E. Trope,
J. Gonzalez, L. D. Wagschal, D. Jinapriya, Y. M.
Buys. Ophthal/Toronto Western Hosp, University
Toronto, Toronto, ON, Canada *CR, f
3176 — A0346 Trabectome-Mediated Ab
Interno Trabeculectomy in Highly Complex
Glaucomas. Ralitsa Loewen1, E. Lagouros2, N.
A. Loewen2. 1Surgery, University of Pittsburgh,
Pittsburgh, PA; 2Ophthalmology, University of
Pittsburgh, Pittsburgh, PA *CR
3177 — A0347 Trabectome outcomes by
single surgeon. Michael C. Stiles. Stiles Eyecare
Excellence, Overland Park, KS *CR
3178 — A0348 Effect of Trabectome in Patients
with Prior Failed Tube Shunts Surgery. Sameh
Mosaed. University of California, Irvine, Irvine, CA
3179 — A0349 Comparison of Trabectome Ab
Interno Trabeculectomy to Baerveldt and Ahmed
Glaucoma Implants. Sushma Kola1, E. Lagouros1,
K. Kaplowitz2, R. Davis1, J. S. Schuman1, 3, N. A.
Loewen1. 1UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh School of Medicine, Pittsburgh,
PA; 2Department of Ophthalmology, Stony
Brook University Medical Center, Stony Brook,
NY; 3Department of Bioengineering, Swanson
School of Engineering, University of Pittsburgh,
Pittsburgh, PA *CR
3180 — A0350 Outcome of Trabectome
for Patients with Failed Glaucoma Drainage
Device. Garrick Chak, S. Mosaed. Ophthalmology,
Gavin Herbert Eye Inst, UC Irvine, Irvine, CA
3181 — A0351 Retrospective review of surgical
outcome with iStent surgery. Ahmad Alali1, 2,
S. Jabbour1, H. Saheb1, M. Mydlarski2, 1. 1Mcgill
university, Montreal, QC, Canada;2ophthalmology,
Jewish General Hospital, Montreal, QC, Canada
227
Tuesday Posters
11:00 am – 12:45 pm
3159 — A0329 Toxicity of Mitomycin-C in
the Suprachoroidal Space. Lili Farrokh-Siar1,
P. Harasymowycz2, P. Snyder3, C. A. Girkin4, J.
Stiles3, G. Simon5. 1Illinois Glaucoma Center, Ltd.,
Tinley Park, IL; 2Institut du Glaucome de Montreal,
Montreal, QC, Canada; 3Purdue University, West
Lafayette, IN; 4University of Alabama Birmingham,
Birmingham, AL;5Instituto de Oftalmología Gabriel
Simón, Madrid, Spain *CR
3163 — A0333 Long-term Comparative
Results of Trabeculectomy in Patients with
Exfoliative Glaucoma versus Primary Open
Angle Glaucoma. Sooncheol Cha, W. Gu, S. Lim,
M. Sagong. Ophthalmology, Yeungnam University
Hospital, Daegu, Republic of Korea
3182 — A0352 Comparison of Surgical
Outcome after Ahmed Valve Implantation
for Glaucoma Patients With and Without
Fluocinolone Intravitreal Implant (Retisert®).
Lauren Hennein1, 2, J. Hou3, E. Lowry1, 2, J. M.
Stewart1, Y. Han1. 1Ophthalmology, University
of California San Francisco, San Francisco,
CA; 2UCSF School of Medicine, San Francisco,
CA; 3Ophthalmology, People Hospital, Beijing,
China
3183 — A0353 Effects of Ahmed glaucoma
valve implantation on corneal decompensation
and changes in corneal endothelial cells. Kyoung
Nam Kim, H. Lee, J. Kim, S. Lee, C. Kim.
ophthalmology, Chungnam National University
Hospital, Daejeon, Republic of Korea
3184 — A0354 Ahmed Glaucoma Valves in
Pediatric Glaucoma - 10 Year Outcomes. Andrew
Chen, F. Yu, A. L. Coleman, J. A. Giaconi, S. K.
Law, J. Caprioli. Ophthalmology, Jules Stein Eye
Institute, UCLA, Los Angeles, CA *CR
Tuesday Posters
11:00 am – 12:45 pm
3185 — A0355 Outcomes of Ahmed glaucoma
valve implantationTM in refractory pediatric
glaucoma. SIRISHA Senthil, P. Dave, A. Roy, H.
Rao, A. K. Mandal, C. S. Garudadri. Glaucoma, L V
Prasad Eye Institute, Hyderabad, India
3186 — A0356 The Use and Safety of
the Ahmed Aqueous Shunt (FP-7) for the
Management of Pediatric Glaucoma. Dilshad
Contractor1, B. J. Reiser1, 2, Y. Murakami2. 1The
Vision Center, Childrens Hospital of Los Angeles,
Los Angeles, CA; 2Ophthalmology, University of
Southern California, Los Angeles, CA
3187 — A0357 Novel Venting Stitch
Technique in Controlling Postoperative
Intraocular Pressure in Baerveldt Glaucoma
Implants. Anhtuan H. Nguyen1, A. Nugent2, V.
Chopra2, B. A. Francis2, J. C. Tan2. 1University of
Texas School of Medicine at San Antonio, San
Antonio, TX; 2University of Southern California
Eye Institute, Los Angeles, CA
3188 — A0358 Time-Related Reduction in
Ahmed Valve Flow Resistance: A 6-Month
Study using a Novel In Vitro Pulsatile Perfusion
Apparatus. Matthew J. Rickard. Bioengineering,
California Baptist University, Riverside, CA
3189 — A0359 Clinical assessment of valvular
needling for the adequate control of intraocular
pressure in patients with Ahmed Glaucoma Valve
Implant Results to a year of evolution. Tania
Moron Vidal, J. Jimenez-Arroyo, M. García-Huerta,
I. Perez Gudino, J. Jimenez-Roman. Asociación
para Evitar la Ceguera en México, México, Distrito
Federal, Mexico
3191 — A0361 Clinical experience with
Baerveldt 350 mm2 glaucoma implant
performed by residents and fellows in training.
Daniela T. Nagatsuyu, I. M. Tavares, R. M. Vessani.
Ophthalmology, Federal University of São Paulo,
São Paulo, Brazil
3192 — A0362 Histopathologic
Characterization of Baerveldt Glaucoma
Implant Capsules in Human Eyes. Antonio J.
Bermudez1, 2, J. Thompson1, 2, S. R. Dubovy1, 2, R.
K. Lee2, S. De la O-Perez1, 2. 1Ocular Pathology,
Bascom Palmer Eye Institute, Miami, FL;
2
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL
3193 — A0363 The Effect of Removing
Pro-inflammatory Cytokines from Molteno
Implant Blebs with Elevated Intraocular
Pressure. Azra Idrizovic1, J. Freedman2, P.
Iserovich3, 4. 1Ophthalmology, St Johns Episcopal
Hospital, Far Rockaway, NY; 2Ophthalmology,
SUNY Brooklyn, Brooklyn, NY; 3Ophthalmology,
Columbia University, New York, NY; 4Seleva
Ophthalmics, New Windsor, NY *CR
3194 — A0364 Simultaneous Implantation
of Two Glaucoma Drainage Devices for
Uncontrolled Advanced Glaucoma. Veena
Rao1, J. Christenbury1, P. P. Lee2, L. W. Herndon1,
P. Challa1. 1Ophthalmology, Duke Eye Center,
Durham, NC; 2Ophthalmology, University of
Michigan, Kellogg Eye Center, Ann Arbor, MI
3195 — A0365 Assessment of LongTerm Serious Corneal Complications from
a Retrospective Review of 401 Baerveldt
350mm2 Glaucoma Implants With Scleral Patch
Graft Performed from 1995 to 2011. Bingjie Ling,
J. Cui, J. T. Patrie, B. E. Prum. Ophthalmology,
University of Virginia, Charlottesville, VA
3196 — A0366 Baerveldt implant surgery
combined with trabeculectomy versus
Baerveldt surgery alone for the treatment of
glaucoma. Shuri Kawamorita1, T. Hamanaka1, T.
Sakurai2. 1Ophthalmology, Japanese Red Cross
Medical Center, Shibuya, Japan; 2Center of General
Education, Tokyo University of Science Suwa,
Chino, Japan
3197 — A0367 Clinical outcomes of
eyes with aqueous shunt implants after
phacoemulsification. David Plemel1, R. Puertas1,
K. Barton1, 2. 1NIHR Biomedical Research Centre
for Ophthalmology, Moorfields Eye Hospital,
London, United Kingdom; 2Department of
Genetics and Epidemiology, UCL Institute of
Ophthalmology, London, United Kingdom *CR
3198 — A0368 Wound healing modulation
in glaucoma filtering surgery with plasma
rich in growth factors: a case series study.
Ignacio Rodriguez-Agirretxe1, 2, E. DiezFeijoo1, A. Acera3, V. Freire1, J. Recalde1, A.
Onaindia1. 1Ophthalmology, ICQO, Bilbao,
Spain; 2Ophthalmology, Donostia Hospital, San
Sebastian, Spain; 3Bioftalmik SL, Derio, Spain
3199 — A0369 Expression of Angiotensin II
and its role in human Tenon’s capsule fibroblasts
proliferation, migration and phenotype
transition. Huimin Shi, Y. Xiao, W. Ye. Department
of Ophthalmology, Huashan Hospital, Fudan
University, Shanghai, China
3200 — A0370 Effects of β-catenin inhibitor,
ICG-001, on cultured human conjunctival
fibroblast. Osamu Yamanaka1, W. W. Kao2, S.
Saika1. 1Ophthalmology, Wakayama Medical
University, Wakayama, Japan; 2Ophthalmology,
University of Cincinnati, Cincinnati, OH
3201 — A0371 in vivo imaging of MMP2 expression in the conjunctiva following
implantation of Ilomastat or ethylcellulose tissuetablet. Ashkan Khalili1, G. Sharma2, 1, H. Khalili2, 1,
G. Bennett3, A. Lockwood1, 2, S. Brocchini2, 1,
P. Khaw1. 1NIHR Biomedical Research Centre
for Ophthalmology, Moorfields Eye Hospital &
UCL Institute of Ophthalmology and School of
Pharmacy, London, United Kingdom; 2UCL School
of Pharmacy, London, United Kingdom; 3Bicycle
Therapeutics Ltd, Cambridge, United Kingdom *CR
3202 — A0372 An ethylcellulose spacer is
similar to mitomycin C in prolonging bleb
survival in an experimental animal model.
Alastair Lockwood1, 2, A. Mohamed Ahmed1, 2,
A. Khalili1, 2, S. Awwad1, 2, G. Sharma1, 2, A.
D. Habeeb1, 2, H. Khalili1, 2, S. Brocchini1, 2, P.
Khaw1. 1National Institute for Health Research
(NIHR) Biomedical Research Centre at Moorfields
Eye Hospital NHS Foundation Trust and UCL
Kingdom; 2UCL School of Pharmacy, London,
United Kingdom *CR
3203 — A0373 Co-culture of Human Tenon
Fibroblast and macrophages as a novel invitro model for conjunctival scarring. Garima
Sharma1, 2, H. Khalili1, 2, H. Li1, A. Khalili1, A.
Lockwood1, 2, D. Gilroy3, S. Brocchini1, 2, P.
Khaw1, M. Bailly1. 1National Institute for Health
Research (NIHR) Biomedical Research Centre at
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology, London, United
Kingdom; 2UCL School of Pharmacy, London,
United Kingdom; 3Div Medicine, University
3190 — A0360 Long-term outcomes of
Baerveldt glaucoma implant (BGI) shunts.
Mirela Krasniqi1, D. P. Edward2, 3, J. Dunmire1,
E. Lagouros1, R. Bouhenni1, M. Willett1, T.
Woodruff1. 1Ophthalmology, Summa Health
System, Akron, OH; 2Ophthalmology, King
Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia; 3Ophthalmology, Wilmer Eye Institute/
Johns Hopkins University, Baltimore, MD
228
3204 — A0374 Losartan efficacy in supressing
responses contributing to fibrosis in TGF-betastimulated Tenon’s fibroblasts. Jayter S. Paula1,
C. M. Modulo1, E. M. Rocha1, P. S. Reinach1,
M. C. Frade2. 1Department of Ophthalmology,
USP - Ribeirao Preto Medical School, Ribeirao
Preto, Brazil; 2Division of Dermatology - Internal
Mecidine Department, USP - Ribeirão Preto
Medical School, Ribeirão Preto, Brazil *CR
3205 — A0375 Suberoylanilide Hydroxamic
Acid (SAHA) Inhibits Excess Fibrosis in
Glaucoma Filtration Surgery: the Animal Study
and Molecular Mechanisms. Huiyi Chen1, 2,
A. Sharma2, 3, M. Reyes1, 2, N. R. Sinha2, 3, S.
Siddiqui2, 3, R. R. Mohan2, 3. 1Ophthalmology, Mason
Eye Institute, University of Missouri-Columbia,
Columbia, MO; 2Harry S Truman VA Hospital,
Columbia, MO; 3College of Veterinary Medicine,
University of Missouri-Columbia, Columbia, MO
3206 — A0376 Evaluation of the α5β1-integrininhibitor CLT-28643 in a trabeculectomy rabbit
model. Maximilian Schultheiss1, S. Schnichels1, E.
Konrad1, K. Bartz-Schmidt1, G. Zahn2, P. Caldirola2,
M. G. Fsadni2, 3, N. Caram-Lelham2, 4, M. S.
Spitzer1. 1Department of Ophthalmology, University
of Tuebingen, Tuebingen, Germany; 2Clanotech
AB Stockholm, Stockholm, Sweden; 3International
Pharm-Med Ltd, Hertfordshire, United
Kingdom; 4Encecor, Uppsala, Sweden *CR
3208 — A0378 The up-regulation of the activin
receptor-like kinase5 in the subconjunctival
wound healing. Shuhao Fu, Y. Xiao, W. Ye.
Ophthalmology, Huashan Hospital Fudan
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Cornea
340 Immunology, angiogenesis
and genetics
Moderator: Frank Larkin
3209 — B0116 Stromal Rejection After
Deep Anterior Lamellar Keratoplasty. Yumiko
HIrayama1, A. Endo1, H. Mitamura1, T. Yamaguchi1,
M. Hirayama2, D. Tomida1, S. Den1, Y. Satake1,
J. Shimazaki1. 1Ophthalmology, Tokyo Dental
Collage Ichikawa General Hospital, Ichikawa,
Japan; 2Department of Ophthalmology, Keio
university, Tokyo, Japan
3211 — B0118 Donor- and third party-derived,
but not recipient-derived mesenchymal stromal
cells, promote corneal allograft survival in
rats. Oliver Treacy, L. O›Flynn, A. Ryan, M.
Morcos, P. Lohan, S. Schu, M. Wilk, M. Griffin, M.
Nosov, T. Ritter. Regenerative Medicine Institute
(REMEDI), National University of Ireland, Galway,
Galway, Ireland
3212 — B0119 Immunohistochemical detection
of decorin in rat corneal transplants following
treatment with immunomodulatory donor bone
marrow derived dendritic cells.Thomas Ritter1,
H. Croke2, K. Kloke2, M. Morcos1, L. O’Flynn1, F.
Quondamatteo2. 1Medicine, Regenerative Medicine
Institute, National University of Ireland, Galway,
Galway, Ireland;2Skin and ECM Research Group,
Discipline of Anatomy, National University of
Ireland, Galway, Galway, Ireland
3213 — B0120 Anti-pig antibody response
and changes in B cell memory phenotype
following wild-type pig-to-monkey corneal
xenotransplantation. Hidetaka Hara1, A.
Mammen2, W. Lee1, Y. Miyagawa1, C. Long1,
D. Ayares3, D. Dhaliwal2, D. Cooper1. 1Surgery,
Thomas E. Starzl Transplantation Institute,
University of Pittsburgh, Pittsburgh,
PA;2Opthalmology, Eye and Ear Institute,
University of Pittsburgh, Pittsburgh, PA; 3Revivicor,
Blacksburg, VA *CR
3214 — B0121 ATRA attenuates corneal
graft rejection by increasing regulatory T cell
and suppressing Th17 cell in the presence of
TGF-β. Qihua Le, X. Wang, W. Wang, J. Xu.
Ophthalmology, Eye & ENT Hospital of Fudan
3215 — B0122 Corneal plasmaytoid dendritic
cells subpopulations demonstrate differential
expression of the functional Siglec-H receptor
that are altered after corneal inflammation. Arsia
Jamali1, M. J. Lopez1, D. L. Harris1, P.
Hamrah1, 2. 1Schepens Eye Research Institute/
Massachusetts Eye and Ear Infirmary, Harvard
Medical School, Boston, MA;2Cornea & Refractive
Surgery Service, Massachusetts Eye & Ear
Infirmary, Department of Ophthalmology, Harvard
3216 — B0123 Elevated IL-6 and IL-23 in Dry
Eye Hosts Disrupt Peripheral Induction of Tregs
and Exacerbate Corneal Allograft Rejection. Jing
Hua, W. Stevenson, T. Inomata, Y. Chen, T. H.
Dohlman, H. Lee, T. Shiang, M. Omoto, R. Dana.
Ophthalmology, Schepens Eye Research Inst,
Boston, MA
3217 — B0124 In Vivo Expansion of
Regulatory T Cells Reduces Corneal
Inflammation in High Risk Corneal
Transplantation. Maryam Tahvildari, M. Omoto,
Y. Chen, S. K. Chauhan, R. Dana. Department of
Ophthalmology, Harvard Medical School, Schepens
Eye Research Institute/Mass. Eye and Ear, Boston,
MA
3218 — B0125 Enhanced allosensitization
following corneal allograft transplantation in
dry eye disease recipients. Antonio Di zazzo, J.
Hua, W. Stevenson, T. Inomata, T. Shiang, T. H.
Dohlman, S. Lee, M. Omoto, Q. Zhang, R. Dana.
Ophthalmology, Harvard Medical School, Boston,
MA
3219 — B0126 Effect of the Topical Selective
Glucocorticoid Receptor Agonist, Mapracorat,
in Experimental Dry Eye Disease. Susanne
Eiglmeier1, 2, Z. Sadrai1, 2, Y. Chen1, 2, S. K.
Chauhan1, 2, R. Dana1, 2. 1Schepens Eye Research
Institute, Boston, MA; 2Massachusetts Eye and Ear
Infirmary, Boston, MA *CR
3220 — B0127 Expression of P- and E-Selectin
in Corneal Transplantation. Thomas H. Dohlman,
S. K. Chauhan, M. Omoto, J. Hua, Z. Sadrai, P.
Hamrah, R. Dana. Schepens Eye Research Institute,
MEEI, Harvard Medical School, Boston, MA
3221 — B0128 Impaired Peripheral Induction
of Regulatory T Cells in High-Risk Corneal
Transplantation. Takenori Inomata, J. Hua, M.
Omoto, Q. Zhang, R. Dana. Ophthalmology,
Schepens Eye Research Institute/ Massachusetts
Eye and Ear Infirmary/ Harvard Medical School,
Boston, MA
3222 — B0129 High glucose suppresses
TNF-α induced by interaction between corneal
epithelial cells and dendritic cells. Mari Narumi1,
H. Namba1, Y. Kashiwagi3, H. Yamashita1, M.
Yamakawa2. 1Opthalmology & Vis Sciences,
Yamagata Univ Faculty of Med, Yamagata,
Japan; 2Diagnostic Pathology, Yamagata University
Faculty of Medicine, Yamagata, Japan; 3Nutrition,
Yamagata prefectural yonezawa women, Yonezawa,
Japan *CR
3223 — B0130 A Novel Mouse Model
for Radiation Keratopathy. Deshea L.
Harris1, 2, T. Yamaguchi2, 1, U. von Andrian3,
P. Hamrah2, 1. 1Ophthal-Harvard Med School,
Schepens Eye Research Inst, Boston, MA; 2Cornea
Service, Ophthal-Harvard Med School,
MA; 3Program in Cellular and Molecular Medicine,
Immune Disease Institute/Children, Boston, MA
3224 — B0131 Dry Eye predisposes to Corneal
Neovascularization and Lymphangiogenesis
after Corneal Injury. Yang Kyung Cho1, K. Lee1,
K. Hong1, B. Archer2, B. Ambati2.1Department
of Ophthalmology, St Vincent Hospital, Suwon,
Republic of Korea; 2Ophthalmology, Moran eye
Center, The University of Utah, Salt Lake City, UT
229
Tuesday Posters
11:00 am – 12:45 pm
3207 — A0377 Rho Kinase Inhibitor AMA0526
Improves Surgical Outcome in a Rabbit
Model of Glaucoma Filtration Surgery. Sarah
Van de Velde1, T. Van Bergen1, E. Vandewalle3,
K. Castermans4, N. Kindt4, L. K. Moons2, I.
Stalmans3. 1Lab of Ophthalmology, KULeuven,
Leuven, Belgium; 2Department of Biology,
KULeuven, Leuven, Belgium;3Ophthalmology, UZ
Leuven, Leuven, Belgium; 4Amakem Ophthalmics,
Diepenbeek, Belgium *CR
3210 — B0117 A rabbit model for in vivo
imaging of pre-clinical signs of corneal
inflammation. Samuel D. Hanlon1, K. Dionne1,
S. Panthi1, T. Wilson2, J. J. Nichols1. 1The Ocular
Surface Institute, Univ of Houston College of
Optometry, Houston, TX; 2Johnson and Johnson
Vision Care, Jacksonville, FL *CR
3225 — B0132 Anti-neovascular Effect of
Chondrocyte-derived Extracellular Matrix
on Corneal Alkaline Burns in Rabbits. Hye
Sook Lee1, J. Lee1, C. Kim1, J. Yang1, 2. 1Ocular
Neovascular Disease Research Center, Inje
University Busan Paik Hospital, Busan, Republic
of Korea; 2Department of Ophthalmology, Inje
of Korea
3226 — B0133 Angiogenin reduces immuneinflammation via inhibition of TANK-binding
kinase 1 (TBK1) expression in human corneal
fibroblast cells(HCFs). Kyung Sup Lim, S. Lee,
K. Kim, J. Kim. Department of Ophthalmology,
College of Medicine, Chung-Ang University
Hospital, Seoul 156-755, South Korea, Republic of
Korea
3227 — B0134 Myeloid cells in Corneal
Angiogenesis. Jin Zhao, T. Nagasaki.
Ophthalmology, Columbia University, New York,
NY
Tuesday Posters
11:00 am – 12:45 pm
3228 — B0135 Eotaxin receptor CCR3
is expressed in neovascularized human
corneas. Alberto Haber1, 2, Y. Garfias2, 3, R.
Bolaños2, 3. 1Cornea, Institute of Ophthalmology,
Mexico, Mexico; 2Research Unit, Institute of
Ophthalmology, Mexico, Mexico; 3Department of
Biochemistry, Faculty of Medicine, Universidad
Nacional Autónoma de México, Mexico, Mexico
3229 — B0136 Effect of amniotic membranederived mesenchymal stem cells on innate
immune system and a their usefulness in
ocular cell therapy. Pamela Martinez-Aboytes1,
F. Magaña-Guerrero1, J. Quiroz Mercado1, O.
Rodríguez-Espinosa2, F. J. Sánchez García2,
A. Navas1, Y. Garfias1, 3. 1Research unit,
Ophthalmology Institute Conde de Valenciana,
Mexico City, Mexico; 2Department of Immunology,
Instituto Politécnico Nacional, Mexico City,
Mexico; 3Department of Biochemistry, Universidad
Nacional Autónoma de México, Mexico City,
Mexico
3230 — B0137 Cornea Subepithelial Opacities
in Pediatric Patients Using Opti-Free ® Contact
Lens Solution. Tehilla Steiner, S. R. Kodsi, A.
Steiner. Ophthalmology, North Shore-LIJ Health
System, Great Neck, NY
3231 — B0138 Interleukin(IL)-33 and Thymic
Stromal Lymphopoietin (TSLP), but not IL-25,
induced Allergic Conjunctivitis in Mouse Models
Papain-Induced Conjunctivitis.Yosuke Asada1, 2,
A. Matsuda1, K. Hori1, S. Iwamoto1, N. Ebihara1, A.
Murakami1, S. Nakae2. 1Ophthalmology, Juntendo
University Graduate School of Medicine, Tokyo,
Japan; 2Systems Biology, Center for Experimental
Medicine and Systems Biology, The Institute of
Medical Science, The University of Tokyo, Tokyo,
Japan
3233 — B0140 Ang-2 mediates processes of
lymphatic formation. Sammy Grimaldo, D. Yuen,
L. Chen. UC Berkeley, Berkeley, CA
3234 — B0141 Inhibition of rho-associated
kinase prevents excessive neovascularization
after corneal trauma. Davine Sijnave1, T. Van
Bergen1, E. Vandewalle3, K. Castermans4, N.
Kindt4, L. K. Moons2, I. Stalmans1, 3. 1Department
of Ophthalmology, KULeuven, Leuven,
Belgium; 2Department of Biology, KULeuven,
Leuven, Belgium; 3Ophthalmology, UZ Leuven,
Leuven, Belgium; 4Amakem Ophthalmics,
Diepenbeek, Belgium *CR
3235 — B0142 Nonclinical Development Of
Encorstat®, Donor Corneal Tissue Genetically
Engineered To Prevent Graft Rejection. Scott
Ellis1, K. Mitrophanous1, M. A. Parker2, V. Scripps1,
T. J. McFarland2, M. Hartzell2, B. Appukuttan2, T.
Stout2. 1Oxford BioMedica (UK) Limited, Oxford,
United Kingdom; 2Oregon Health & Sciences
University, Portland, OR *CR
3236 — B0143 Alkali versus suture-induced
corneal neovascularization: an overview
of two common animal models of corneal
neovascularization. Chiara Giacomini, G. Ferrari,
F. Bignami, P. Rama. San Raffaele Scientific Inst,
Milan, Italy
3237 — B0144 Impaired angiogenic response in
cornea by lacking tenascin X in mice. Takayoshi
Sumioka1, Y. Okada1, Y. Nidegawa1, M. Miyajima2,
K. Matsumoto3, S. Saika1.1Ophthalmology,
Wakayama Medical University, Wakayama,
Japan; 2The Animal center, Wakayama Medical
University, Wakayama, Japan; 3Biosignaling and
Radioisotope Experiment, Shimane University,
Interdisciplinary Center for Science Research,
Shimane, Japan
3238 — B0145 Indirect Modulation of
Inflammatory Corneal Lymphangiogenesis by
Interleukin-10. Deniz Hos, B. Regenfuss, F. Bock,
F. Bucher, L. M. Heindl, C. Cursiefen. Department
of Ophthalmology, University of Cologne, Cologne,
Germany
3239 — B0146 Effects of Anti-PDGFRβ
Therapy Alone or in Combination with VEGF
Trap on Corneal Neovascularization (NV) and
Pericyte Recruitment in Mice. Yang Liu, Z. Li,
D. Reef, M. Yuan, J. Cao, G. D. Yancopoulos,
S. J. Wiegand. Regeneron Pharmaceuticals Inc,
Tarrytown, NY *CR
3240 — B0147 Three classes of Cytosinephosphate-guanosine oligodeoxynucleotides
(CpG-ODN) regulate angiogenesis via distinct
pathways. Jiahui Wu, A. D. Dick, L. Liu.
Ophthalmology, University of Bristol, Bristol,
United Kingdom
3232 — B0139 CXCL10 Suppression of hemand lymph-angiogenesis in infected or inflamed
B6 mouse corneas. Nan Gao, X. Liu, C. Dong, F.
X. Yu. Ophthalmology, Wayne State Univ/Kresge
Eye Inst, Detroit, MI
3241 — B0148 Conditional knockout
of Wntless Suppresses Corneal
Lymphangiogenesis. Don Yuen1, M. Wang1, E.
Huang1, N. Wu1, T. Ecoiffier1, A. Smith2, R. A.
Lang2, L. Chen1. 1School of Optometry, Univ of
California at Berkeley, Berkeley, CA; 2Divisions
of Ophthalmology and Developmental Biology,
Cincinnati Children, Cincinnati, OH
3242 — B0149 The effect of topical
Epigallocatechin Gallate on corneal
neovascularization in rabbits. Jae Yon Won, C.
Koh, S. Chung. Department of Ophthalmology and
Visual Science, The Catholic University of Korea,
3243 — B0150 Substance P Expression And Its
Inhibition In Corneal Neovascularization. Giulio
Ferrari, F. Bignami, C. Giacomini, P. Rama.
Ophthalmology -Cornea Unit-Eye Repair, San
Raffaele Scientific Institute, Milan, Italy *CR
3244 — B0151 Angiopoietin like protein 7
is a novel anti-angiogenic molecule expressed
in cornea. Tetsuya Toyono, T. Usui, S. Yokoo,
S. Nakagawa, S. Yamagami, S. Amano.
Ophthalmology, University of Tokyo, Bunkyo-ku,
Japan
3245 — B0152 Blockade of Epithelial
Membrane Protein-2 Decreases Corneal
Neovascularization in a Burn Model. Ann M.
Chan1, M. H. Kiyohara2, C. M. Dillard2, W. Wang1,
M. Wadehra2, L. K. Gordon1. 1Jules Stein Eye
Institute, University of California, Los Angeles, Los
Angeles, CA; 2Pathology and Laboratory Medicine,
University of California, Los Angeles, Los Angeles,
CA *CR
3246 — B0153 Photodynamic Therapy With
Verteporfin for Corneal Neovascularization.
Rodrigo Bolanos1, 2, S. Sarmina1, G. Dewit1,
A. J. Ramirez-Miranda2, E. O. Graue2, A.
Navas2. 1Ophthalmology Service, Regional
Hospital, Licenciado Adolfo López Mateos,
ISSSTE, Mexico City, Mexico, Mexico City,
Mexico; 2Cataract and Refractive Surgery, Institute
of Ophthalmology Conde de Valenciana, Mexico
City, Mexico
3247 — B0154 Corneal angiography for
assessing, guiding and evaluating treatment of
corneal neovascularisation. Natasha Spiteri, J.
Chen, Y. Zheng, V. Romano, A. Tey, S. Yadav, S.
Ahmad, S. Kaye. St Paul›s Eye Unit, Liverpool,
United Kingdom
3248 — B0155 Fluorescent vascular
imaging shows that TLR4 knockout reduces
neovascularization and corneal scar after
mouse corneal burn injury. James Nicholson1, 4,
D. Morzaev1, 4, S. Weiss1, 4, E. Hochhauser2, 4, N.
Goldenberg-Cohen1, 3. 1The Krieger Eye Research
Laboratory, Felsenstein Medical Research
Center, Petach Tikva, Israel; 2Laboratory of
Cardiac Research, Felsenstein Medical Research
Center, Petach Tikva, Israel; 3Department of
Ophthalmology, Pediatric Unit, Schneider Children,
Petach Tikva, Israel; 4Sackler School of Medicine,
Tel Aviv University, Tel Aviv, Israel
230
3249 — B0156 Raver2 preserves corneal
avascularity by increasing sFlt1 Production.
Subrata Das, D. G. Holt, H. Uehara, X. Zhang, B.
Archer, B. Ambati. Ophthalmology, John Moran
Eye Center/University of Utah, Salt Lake City, UT
3250 — B0157 Transplantation of PEDFTransfected Pigment Epithelial Cells
Inhibits Corneal Neovascularization in a
Rabbit Model. David Kürten1, S. Johnen1, 3, G.
Thumann2. 1Ophthalmology, Uniklinik Aachen,
Aachen, Germany; 2Ophthalmology, HUG, Geneva,
Switzerland; 3IZKF Aachen, RWTH Aachen,
Aachen, Germany
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Genetics / Retinal Cell Biology / Retina
341 Genetics II: Genetics of Retinal
Degenerations and Dystrophies
Moderators: Andrew Lotery, Edwin M. Stone
and Stephen P. Daiger
3252 — B0192 Detection of the ABCA4 gene
mutations using next-generation sequencing.
Monika Oldak1, A. Sciezynska1, A. Ambroziak2, M.
Korwin2, R. Ploski3, J. P. Szaflik2, J. Szaflik2. 1Dept
of Histology and Embryology, Medical University
of Warsaw, Warsaw, Poland; 2Department of
Ophthalmology, Medical University of Warsaw,
Warsaw, Poland; 3Department of Medical Genetics,
Medical University of Warsaw, Warsaw, Poland
3253 — B0193 Analysis of the
entire ABCA4 genomic locus in Stargardt disease
patients in search for missing mutations. Jana
Zernant1, C. Ayuso3, F. Simonelli4, M. Bertelsen5,
T. Rosenberg5, M. Gorin6, B. Yuan7, P. L. Nagy2, R.
Allikmets1, 2. 1Ophthalmology, Columbia University,
New York, NY; 2Pathology and Cell Biology,
Columbia University, New York, NY;3Clinical
Genetics, University Hospital Fundación Jiménez
Díaz, Madrid, Spain; 4Ophthalmology, Second
University of Naples, Naples, Italy; 5University of
Copenhagen, Copenhagen, Denmark; 6Jules Stein
Eye Institute, Los Angeles, CA; 7Molecular and
Human Genetics, Baylor College of Medicine,
Houston, TX *CR
3255 — B0195 A model for predicting the
likelihood of identifying ABCA4 mutations for
Stargardt disease. Jillian Huang, S. Zahid, K.
E. Branham, J. R. Heckenlively, T. Jayasundera.
Ophthalmology and Visual Sciences, Kellogg Eye
Ctr, Univ of Michigan, Ann Arbor, MI
3256 — B0196 CRX mutations in patients with
phenotypes resembling Stargardt disease. Yajing
Xie1, S. H. Tsang1, 2, C. Ayuso4, W. Lee1, S. N.
Jhangiani3, T. Gambin3, B. Yuan3, J. R. Lupski3, R.
Allikmets1, 2. 1Opthalmology, Columbia University,
New York, NY; 2Pathology & Cell Biology,
Columbia University, New York, NY; 3Molecular
and Human Genetics, Baylor College of Medicine,
Houston, TX; 4Clinical Genetics, University
Hospital Fundación Jiménez Díaz, Madrid, Spain
3257 — B0197 Autosomal recessive
besotropinopathy: A novel mutation in BEST1
gene in a consanguinous family. Genotype/
Phenotype correlation and follow up of 3 years.
Veronika Vaclavik, F. L. Munier, V. H. Tran, D.
F. Schorderet. Department of ophthalmology,
University of Lausanne, Jules Gonin Eye Hospital,
Lausanne, Switzerland
3258 — B0198 BEST1 mutations in Japanese
patients with Best vitelliform macular
dystrophy. Satoshi Katagiri1, 2, T. Hayashi1, T.
Sekiryu3, T. Gekka1, M. Akahori2, H. Sasano1, Y.
Ohkuma1, T. Iwata2, H. Tsuneoka1. 1Department
of Ophthalmology, Jikei University, School of
Medicine, Tokyo, Japan; 2Division of Molecular
and Cellular Biology, National Institute of Sensory
Organs, National Hospital Organization Tokyo
Medical Center, Tokyo, Japan; 3Department of
Ophthalmology, Fukushima Medical University
School of Medicine, Fukushima, Japan
3259 — B0199 Screening for BEST1 gene
mutations in Chinese patients with vitelliform
macular dystrophy. Rong Tian1, G. Yang2, J.
Wang1, Y. Chen1. 1Department of Ophthalmology,
Peking Union Medical College Hospital, Peking
Union Medical College and Chinese Academy of
Medical Science, Beijing, China; 2Department of
Ophthalmology, Xingtai Eye Hospital, Xingtai,
China
3261 — B0201 Mutation Analysis of
the USH2A Gene in Japanese Patients
with Autosomal Recessive Retinitis
Pigmentosa. Katsuhiro Hosono1, Y. Zhao1, C.
Ishigami2, S. Ueno3, H. Nakanishi4, H. Terasaki3,
M. Kondo5, M. Takahashi2, S. Minoshima6, Y.
Hotta1. 1Department of Ophthalmology, Hamamatsu
University School of Medicine, Hamamatsu,
Japan;2Laboratory for Retinal Regeneration,
RIKEN Center for Developmental Biology, Kobe,
Japan; 3Department of Ophthalmology, Nagoya
University Graduate School of Medicine, Nagoya,
Japan; 4Department of Otorhinolaryngology/Head
& Neck Surgery, Hamamatsu University School
of Medicine, Hamamatsu, Japan; 5Department
of Ophthalmology, Mie University School of
Medicine, Tsu, Japan; 6Department of Photomedical
Genomics, Basic Medical Photonics Laboratory,
Medical Photonics Research Center, Hamamatsu
University School of Medicine, Hamamatsu, Japan
3262 — B0202 RPGR, a common source
of missed variants in exome sequencing
experiments. Adam P. DeLuca1, J. C. Giacalone1,
L. A. Wiley1, E. L. Kennedy1, S. E. Miller1, J.
S. Wiley1, B. A. Tucker1, T. Scheetz1, E. M.
Stone1, 2. 1Stephen A. Wynn Institute for Vision
Research, University of Iowa, Iowa City, IA;
2
Howard Hughes Medical Institute, Iowa City, IA
3263 — B0203 Targeted NGS Incidentally
Reveals Klinefelter Syndrome in a Patient
with X-Linked Recessive Retinitis Pigmentosa
and Skewed X Inactivation. Hanno J. Bolz1, 2,
A. Kron1, T. Eisenberger1, C. Decker1, B. Seipel1,
C. Kraus3, C. Bergmann1, 4, C. Neuhaus1. 1Center
for Human Genetics, Bioscientia, Ingelheim,
Germany; 2Institute of Human Genetics, University
Hospital of Cologne, Cologne, Germany; 3Institute
of Human Genetics, Friedrich-Alexander University
Erlangen-Nuremberg, Erlangen, Germany; 4Center
for Clinical Research, University Hospital of
Freiburg, Freiburg, Germany *CR
3264 — B0204 Molecular characterization
of SNRNP200 mutations causing autosomal
dominant retinitis pigmentosa with incomplete
penetrance and phenotypic variability.
Carlo Rivolta1, P. Benaglio1, T. Guillaumie2,
G. Manes3, S. Harper4, E. L. Berson4, I.
Meunier2, C. P. Hamel3. 1Department of Medical
Genetics, University of Lausanne, Lausanne,
Switzerland; 2Service d’Ophtalmologie,
Université et Hôpital de Montpellier, Montpellier,
France; 3U1051, Inserm, Montpellier,
France; 4Berman-Gund Lab/Ophthal, Harvard
3260 — B0200 Molecular analysis of a
large cohort of Chinese patients with retinitis
pigmentosa by Whole exome next generation
sequencing. Xianjun Zhu1, L. Huang1, Y. Li3, P.
Zhao2, Z. Yang1, 2. 1Center for Human Molecular
Genetics, Sichuan Provincial Hospital, Chengdu,
China; 2Department of Ophthalmology, Xin Hua
Hospital affiliated to Shanghai Jiao Tong University
School of Medicine, Shanghai, China; 3Department
of Ophthalmology, Tongren Hospital, Beijing,
China
231
Tuesday Posters
11:00 am – 12:45 pm
3251 — B0191 Analysis of ABCA4related retinal dystrophies without
fundus abnormalities. Nathalie M. Bax1, S.
Lambertus1, R. A. Huet1, F. P. Cremers2, C. C.
Hoyng1.1Ophthalmology, Radboud University
Medical Centre, Nijmegen, Netherlands; 2Human
Genetics, Radboud University Medical Centre,
Nijmegen, Netherlands
3254 — B0194 Identification of 4 novel
mutations in the ABCA4 gene in brazilian
patients with Stargardt disease type I. Rafael
Purissimo1, M. P. Avila1, J. Chiang2, L. Dourado
Alves1, L. G. Freitas1, R. C. Cruvinel1, C. Sousa1,
C. B. Paiva1, R. Yamamoto1, L. A. Gabriel1. 1Cerof,
Goiania, Brazil; 2Casey Molecular Diagnostic
Laboratory, Casey Eye Institute, Portland, OR
3265 — B0205 Genotype and phenotype
studies in autosomal dominant retinitis
pigmentosa (adRP) of the French Canadian
founder population. Razek Georges Coussa1, 2, C.
Chakarova3, R. Ajlan1, 2, C. Kavalec1, 2, A. Khan1, 2, I.
Lopez2, H. Ren2, N. Waseem3, S. S. Bhattacharya3, 4,
R. K. Koenekoop1, 2. 1Opthalmology, McGill
University, Montreal, QC, Canada;2The
McGill Ocular Genetics Laboratory, Paediatric
Ophthalmology Division, Montreal Children’s
Hospital, McGill University Health Centre,
Montreal, QC, Canada; 3Institute of Ophthalmology,
University College London, London, United
Kingdom; 4Department of Cellular Therapy and
Regenerative Medicine, CSIC - CABIMER,
Seville, Spain
Tuesday Posters
11:00 am – 12:45 pm
3266 — B0206 RDH11, a new gene for
autosomal recessive retinitis pigmentosa with
syndromic features. Rando Allikmets1, 2, Y.
Xie1, W. Lee1, L. Amaro-Quireza1, T. Gambin3,
S. N. Jhangiani3, B. Yuan3, J. R. Lupski3, S. H.
Tsang1, 2. 1Ophthalmology, Columbia University,
New York, NY; 2Pathology & Cell Biology,
Columbia University, New York, NY; 3Baylor
3267 — B0207 A novel locus for autosomal
dominant retinitis pigmentosa (adRP) on
chromosome 19q13. Stephen P. Daiger1, J. D.
Churchill1, S. J. Bowne1, L. S. Sullivan1, S. H.
Blanton2, D. C. Koboldt1, G. Weinstock3, D. K.
Wheaton4, D. G. Birch4. 1Human Genetics Center,
School of Public Health, Univ. of Texas Health
Science Center, Houston, TX; 2Hussman Institute
of Human Genomics, Univ. of Miami, Miami,
FL; 3The Genome Institute, Washington Univ., St.
Louis, MO; 4Retina Foundation of the Southwest,
Dallas, TX
3268 — B0208 Mutation screening in patients
with retinal dystrophies using a Panel-based
Next Generation Sequencing approach. Nicole
Weisschuh1, A. Mayer1, N. Gloeckle2, S. Kohl1, S.
Biskup2, B. Wissinger1. 1Institute for Ophthalmic
Research, Tuebingen, Germany; 2CeGaT GmbH,
Tuebingen, Germany *CR
3269 — B0209 Deciphering the genetic
architecture of retinitis pigmentosa through
a combination of panel and whole exome
sequencing. Feng Wang1, L. Zhao1, H. Wang1, D. A.
Simpson5, S. P. Daiger6, S. Giuliana5, K. Zhang4, R.
K. Koenekoop3, R. Sui2, R. Chen1. 1Baylor College
of Medicine, Houston, TX; 2Peking Union Medical
College Hospital, Peking Union Medical College,
Beijing, China; 3McGill University Health Centre,
Montreal, QC, Canada; 4University of California
San Diego, La Jolla, CA; 5Queen’s University
Belfast, Belfast, United Kingdom; 6The University
of Texas HSC at Houston, Houston, TX *CR
3270 — B0210 Progressive Retinal Atrophy in
the Karelian Beardog; A Large Animal Model
for Retinitis Pigmentosa. Saija J. Ahonen1, 2,
H. Lohi2, 3. 1Molecular Neurology, University
of Helsinki, Helsinki, Finland; 2Veterinary
Biosciences, University of Helsinki, Helsinki,
Finland; 3The Folkhälsan Institute of Genetics,
Folkhälsan, Helsinki, Finland
3271 — B0211 Is C8orf37 the eighteenth
BBS gene? A case report. Elise Heon1, 2, S.
Qin1, H. Dollfus3, V. Sheffield4, E. M. Stone5, G.
Billingsley1, A. Vincent1, 2. 1Ophthalmology &
Vision Sciences and The Program of Genetics and
Genomic Biology, Hospital for Sick Children,
Toronto, ON, Canada; 2Ophthalmology & Vision
Canada; 3Service de Génétique Médicale, Hôpital
de Hautepierre, Strasbourg, France; 4Departments
of Pediatrics and Ophthalmology and HHMI,
University of Iowa, Iowa City, IA;5Department
Ophthalmology, University of Iowa, Iowa City, IA
3272 — B0212 Molecular Modeling of USH2A
Domains and Structural Significance of Genetic
Changes in Usher Disease. Yuri V. Sergeev.
OGVFB, National Eye Institute, Bethesda, MD
3273 — B0213 Phenotypic characterization
of patients with PRPH2 mutations. Kari E.
Branham, N. W. Khan, J. Huang, T. Jayasundera,
J. R. Heckenlively. Ophthalmology and Visual
Sciences, University of Michigan, Ann Arbor, MI
3274 — B0214 Targeted Next Generation
Sequencing identifies novel mutations in RP1
as a relatively common cause of Autosomal
Recessive Rod-Cone Dystrophy. Said El Shamieh1,
M. Lancelot1, S. Mohand-Saïd1, 2, J. A. Sahel1, 2, I.
Audo1, 2, C. Zeitz1. 1Institut de la vision, Univ Poerre
et Marie Curie, Paris 6, INSERM, UMR_S986,
CNRS, UMR_7210, Paris, France; 2CHNO,
INSERM-DHOS CIC503, Paris, France
3275 — B0215 Novel nonsense mutation
in C2orf71 gene in a brazilian patient with
autosomal recessive cone-rod dystrophy. Luisa
S. M. Mendonca1, M. P. Avila1, I. B. Silva1, L. C.
Lavigne1, T. Oliveira1, J. Chiang2, A. Jordão1, A.
T. Rassi1, L. F. Chaves1, L. A. Gabriel1. 1Ocular
Genetics, CEROF, Goiania, Brazil; 2Casey
Molecular Diagnostic Laboratory, Casey Eye
Institute, Portland, OR
3276 — B0216 A cone-rod dystrophy patient
with a homozygous RP1L1 mutation. Shuhei
Kameya1, S. Kikuchi1, K. Gocho1, S. El Shamieh2,
K. Akeo1, Y. Sugawara3, K. Yamaki1, C. Zeitz2,
I. Audo2, H. Takahashi4. 1Ophthalmology,
Chiba Hokusoh Hosp Nippon Med Sch, Inba,
Japan; 2Genetics, INSERM, U968, CNRS,
UMR_7210, UPMC Univ Paris 06, UMR_S
968, Institut de la Vision, Paris F-75012,
France; 3Ophthalmology, Honjo Daiichi Hospital,
Yurihonjo, Japan; 4Ophthalmology, Nippon Medical
School, Sendagi, Japan
3277 — B0217 Novel ADAM9 mutation
in a consanguineous Egyptian family
with severe Cone-Rod Dystrophy. Cecilia
Jakobsson1, 3, W. El-Haig2, H. Abouzeid1, 3, D. F.
Schorderet3, 4. 1Jules-Gonin eye hospital, Lausanne,
Switzerland; 2Opthalmology, Zagazig University,
Ash Sharqiyah, Egypt; 3Institute for Research in
Ophthalmology, Sion, Switzerland;4Faculté des
Sciences du Vivant, Ecole polytechnique fédérale de
Lausanne, Lausanne, Switzerland
3278 — B0218 A new form of syndromic cone
dystrophy: First case report of a 21 year old
female with cone dystrophy associated with
short anagen hair syndrome. Tauan Oliveira1,
L. Dourado2, L. Dourado Alves1, I. B. Silva1, L.
M. Mendonca1, L. F. Queiroz1, M. P. Avila1, L.
A. Gabriel1. 1Ocular Genetics, CEROF, Goiania,
Brazil; 2Dermatology Department UFG, UFG,
Goiania, Brazil
3279 — B0219 Phenotypic variability of
retinal dystrophies associated with mutations
in CRX: with report of a novel macular
dystrophy phenotype. Sarah Hull1, 2, G.
Arno1, 2, S. Chamney3, I. Russell-Eggitt4, A. G.
Robson1, 2, G. E. Holder1, 2, A. Webster1, 2, A. T.
Moore1, 2. 1Moorfields Eye Hospital, 162 City
Road, London, United Kingdom; 2Inherited Eye
Diseases, UCL Institute of Ophthalmology, London,
United Kingdom; 3Ophthalmology Department,
Royal Victoria Hospital, Belfast, United
Kingdom; 4Ophthalmology Department, Great
Ormond Street Hospital for Children NHS Trust,
3280 — B0220 Increased expression of
inflammatory markers in the RPE of CfhTg mice
and in RD8+/+ mice. Cynthia X. Wang, B. Aredo,
T. Li, R. Ufret-Vincenty. Ophthalmology, UT
Southwerstern Medical Center, Dallas, TX
3281 — B0221 Correction of the Crb1rd8 allele
and retinal phenotype in C57BL/6N mice via
TALEN-mediated homology-directed repair. Mark
P. Krebs1, B. E. Low1, J. Joung2, 3, S. Q. Tsai4, P. M.
Nishina1, M. V. Wiles1. 1The Jackson Laboratory,
Bar Harbor, ME; 2Molecular Pathology Unit,
Center for Computational and Integrative Biology,
Massachusetts General Hospital, Charlestown,
MA; 3Center for Cancer Research, Massachusetts
General Hospital, Charlestown, MA; 4Department
of Pathology, Harvard Medical School, Boston,
MA *CR
3282 — B0222 Genomewide search for
genetic modifiers in patients with Leber
congenital amaurosis using whole exome
sequencing. Rinki Ratna Priya1, D. Zipprer1,
X. Zhan2, J. S. Friedman1, S. B. Schwartz3, D.
Sharon4, E. Banin4, G. Abecasis2, S. G. Jacobson3,
A. Swaroop1. 1Neurobiology-Neurodegeneration
& Repair Laboratory (N-NRL), National Eye
Institute, Bethesda, MD; 2Center for Statistical
Genetics, Department of Biostatistics, University
of Michigan, Ann Arbor, MI; 3Scheie Eye Institute,
Pennsylvania, Philadelphia, PA; 4Hadassah-Hebrew
University Medical Center, Jerusalem, Israel
232
3283 — B0223 A Novel Nonsense Mutation
in KCNJ13 Causes Leber Congenital
Amaurosis. Bikash R. Pattnaik1, M. J. Marino2, J.
Chiang3, D. M. Pillers4, E. I. Traboulsi2.1Pediatrics
Ophthal & Visual Sciences and McPherson Eye
Research Institute, Univ of Wisconsin, Madison,
WI; 2Center for Genetic Eye Diseases and the
Department of Ophthalmic Research, Cole Eye
Institute, Cleveland Clinic Foundation, Cleveland,
OH; 3Casey Molecular Diagnostic Laboratory,
Oregon Health Science University, Portland,
OR; 4Pediatrics, McPherson Eye Research Institute,
University of Wisconsin, Madison, WI
3284 — B0224 A novel exon 17 deletion
mutation of RPGRIP1 gene in two siblings with
Leber congenital amaurosis. Takuro Fujimaki1,
T. Suzuki1, A. Yanagawa1, E. Arai1, K. Fujiki1, Y.
Wada2, A. Murakami1. 1Dept of Ophthalmology,
Juntendo University Graduate School of Medicine,
Bunkyo-Ku, Japan; 2Ophthalmology, Yuko Wada
Eye Clinic, Sendai, Japan
3286 — B0226 An Expanded NMNAT1 Allele
Containing a Partial Gene Duplication is
Associated with Leber Congenital Amaurosis.
Scott H. Greenwald, K. M. Bujakowska, E. Place,
E. Pierce. Ocular Genomics Institute, Massachusetts
Eye and Ear Infirmary, Harvard Medical School,
Boston, MA
3287 — B0227 Is TRPM1 associated
Congenital Stationary Night Blindness
stationary? Wanda L. Pfeifer, R. J. Olson, S. Q.
Longmuir, A. V. Drack. Ophthalmology and Visual
Sciences, University of Iowa, Iowa City, IA
3288 — B0228 Molecular and
immunohistochemical characterization of a
canine model of complete congenital stationary
night blindness (CSNB). Gautami Das1, K.
Miyadera1, E. Santana1, G. D. Aguirre1, M.
Kondo2. 1School of Vet Medicine, University of
Pennsylvania, Philadelphia, PA; 2Ophthalmology,
Mie University Graduate School of Medicine, Tsu,
Japan
3291 — B0231 Comprehensive Molecular
Diagnosis of Inherited Retinal Degeneration by
Combining NGS and aCGH Techniques. Wei Ru
Li, C. Wu, N. Mander, J. Duan, J. Chiang. Casey
Molecular Diagnostics Lab, Oregon Health &
Science Universiyt, Portland, OR
3292 — B0232 Homozygosity Mapping and
Disease Genes Screening in Pakistani Families
with Inherited Retinal Dystrophies. Muhammad
Arif Nadeem Saqib1, E. Ullah1, F. Khan1, G.
Venturini2, K. Nikopoulos2, M. Ansar1, C.
Rivolta2. 1Dept of Biochemistry and Molecular
Biology, Quaid Azam University, Islamabad,
Islamabad, Pakistan; 2Dept of Medical Genetics,
University of Lausanne, Lausanne, Switzerland
3293 — B0233 Exome analysis revealed novel
and known mutations in Indian, Pakistani
and Caucasian pedigrees with recessive retinal
degeneration. Pooja Biswas1, B. Maranhao1,
I. Kozak2, M. Parke3, K. E. Branham4, L. A.
Gabriel5, J. R. Heckenlively4, A. S. Riazuddin6,
J. L. Duncan7, R. Ayyagari1. 1Ophthalmology,
University of California San Diego, San Diego,
CA; 2King Khaled Eye Specialist Hospital,
Riyadh, Saudi Arabia; 3Cornell University, Ithaca,
NY; 4Ophthalmology & Visual Science, University
of Michigan Kellogg Eye Center, Ann Arbor,
MI; 5Genetics and Ophthalmology, Genelabor,
GOIANIA, Brazil; 6Ophthalmology, Johns Hopkins
University School of Medicine, Baltimore,
MD; 7Ophthalmology, University of California San
Francisco, San Francisco, CA
3294 — B0234 Genetic testing in patients with
inherited retinal dystrophies using panel-based
next generation sequencing. Susanne Kohl1, A.
S. Bernd1, N. Gloeckle2, J. Mohr2, E. Zrenner1, B.
Wissinger1, S. Biskup2. 1Centre for Ophthalmology,
Inst for Ophthalmic Rsrch Tuebingen, Tuebingen,
Germany; 2CeGaT GmbH, Tuebingen,
Germany *CR
3289 — B0229 Cacna1f gene related decrease
in skeletal muscle contractility in a congenital
stationary night blindness rat model. Zuoming
Zhang1, J. An1, L. Zhang1, B. Jiao2, F. Lu3, Z.
Yu2. 1Department of Clinical Aerospace Medicine,
Fourth Military Medical University, Xi’an,
China; 2Aerospace Physiology, Fourth Military
Medical University, Xi, China;3Biochemistry
and Molecular Biology, Fourth Military Medical
University, Xi’an, China f
Tuesday, May 06, 2014 11:00 AM-12:45 PM
342 Gene Therapy and Delivery
Moderator: Samantha R. De Silva
3295 — B0235 Gene therapy for
choroideremia: Early functional and anatomical
recovery after subfoveal vector injection.
Markus Groppe1, 2, C. L. Cottriall2, J. K. Jolly1, 2,
R. E. MacLaren1, 2. 1Nuffield Laboratory of
Ophthalmology, University of Oxford, Oxford,
United Kingdom; 2Oxford Eye Hospital, Oxford
University Hospitals NHS Trust, Oxford, United
Kingdom *CR, f
3296 — B0236 Immunological testing in
choroideremia patients undergoing gene
therapy. Alun R. Barnard1, M. Groppe1, 2, L.
Seymour3, R. E. MacLaren1, 2. 1Nuffield Laboratory
of Ophthalmology, University of Oxford, Oxford,
United Kingdom; 2Oxford Eye Hospital, Oxford
University Hospitals NHS Trust and NIHR
Biomedical Research Centre, Oxford, United
Kingdom; 3Department of Oncology, University of
Oxford, Oxford, United Kingdom *CR, f
3297 — B0237 Subretinal delivery of human
melanopsin using capsid mutant AAV 2/8
Y733F results in sustained expression at one
year with restoration of pupil responses in
the rd1 mouse. Samantha R. De Silva1, A. R.
Barnard1, M. S. Singh1, M. McClements1, M.
During2, M. Hankins1, R. E. MacLaren1. 1Nuffield
Laboratory of Ophthalmology, University of
Oxford, Oxford, United Kingdom; 2Ohio State
University, Columbus, OH
3298 — B0238 Analysis of REP1 protein
expression in blood leukocytes in typical
choroideremia patients without an
identifiable REP1 gene mutation. Camiel J.
Boon2, 1, T. Tolmachova4, A. R. Barnard3, S.
M. Downes2, 3, M. Groppe2, 3, A. Webster5, R.
E. MacLaren2, 3. 1Ophthalmology, Leiden Univ
Med Ctr, Leiden, Netherlands; 2Oxford Eye
Hospital, University of Oxford, Oxford, United
Kingdom; 3Nuffield Laboratory of Ophthalmology,
University of Oxford, Oxford, United
Kingdom; 4Imperial College London, London,
United Kingdom;5Moorfields Eye Hospital, London,
United Kingdom
3299 — B0239 Lentiviral Gene therapies
for wet AMD, Stargardt macula dystrophy
and Usher Syndrome 1B : clinical trial
updates. Madhu Davies, S. Ellis, N. Adams,
K. Binley, M. Kelleher, K. Mitrophanous.
Oxford BioMedica (UK) Ltd, Oxford, United
Kingdom *CR, f
233
Tuesday Posters
11:00 am – 12:45 pm
3285 — B0225 Partial NMNAT1 deletions
cause Leber Congenital Amaurosis. Frauke
Coppieters1, T. Fujimaki2, M. De Bruyne1, A. Baert1,
M. Kondo3, A. Murakami2, E. De Baere1. 1Center
for Medical Genetics Ghent, Ghent University,
Ghent, Belgium; 2Department of Ophthalmology,
Juntendo University Graduate School of Medicine,
Tokyo, Japan;3Department of Ophthalmology, Mie
University Graduate School of Medicine, Mie,
Japan
3290 — B0230 Novel mutations and change
of nomenclature for pathogenic variants
in the TIMP3 gene causing Sorsby fundus
dystrophy. Benjamin Bakall1, 2, E. H. Sohn3,
J. Riley3, D. Brack3, E. M. Stone3. 1Associated
Retina Consultants, Phoenix, AZ; 2Ophthalmology,
University of Arizona, College of Medicine
Phoenix, Phoenix, AZ; 3Dept of Ophthalmology,
Wynn Institute for Vision Research, University of
Iowa, Iowa City, IA
Tuesday Posters
11:00 am – 12:45 pm
3300 — B0240 CEP290 gene addition
rescues ciliogenesis in LCA patient cells. Erin
R. Burnight1, L. A. Wiley1, A. V. Drack1, T. A.
Braun1, K. Anfinson1, E. E. Kaalberg1, J. Halder1, R.
Mullins1, E. M. Stone1, 2, B. A. Tucker1. 1Stephen A.
Wynn Institute for Vision Research, Carver College
of Medicine, Iowa City, IA; 2Howard Hughes
Medical Institute, Iowa City, IA
3307 — B0247 Enhancement of light sensitivity
in retinal degeneration in mice by use of
novel optogenetic approaches. Jasmina Cehajic
Kapetanovic, P. N. Bishop, R. J. Lucas. Centre for
Hearing & Vision Research, Institute of Human
Development, Faculty of Medical and Human
Sciences and Faculty of Life Sciences, University of
Manchester, Manchester, United Kingdom
3315 — B0255 Toward a Novel Gene Therapy
for Dry Age-Related Macular Degeneration.
Mark C. Butler2, 1, A. R. Morawski1, M. Zuber1,
J. M. Sullivan1, 2. 1Research Service, VA
Western New York Healthcare System, Buffalo,
NY; 2Ophthalmology (Ross Eye Institute),
University at Buffalo-SUNY; SUNY Eye Institute,
Buffalo, NY *CR
3301 — B0241 Proof of concept for AAVmediated gene transfer in iPSc-derived retinal
pigment epithelium. Vasiliki Kalatzis1, N.
Cereso1, M. Pequignot1, L. Robert1, F. Becker2,
V. De Luca1, N. Nabholz1, V. Rigau3, J. De
Vos2, C. P. Hamel1, 4. 1Inserm U1051, Institute
for Neurosciences of Montpellier, Montpellier,
France; 2Inserm U632, Institute for Research in
Biotherapies, Montpellier, France; 3Department
of Anatomy and Pathological Cytology, CHRU St
Eloi, Montpellier, France; 4Centre of Reference
for Genetic Sensory Diseases, CHRU Montpellier,
Montpellier, France
3308 — B0248 A Single Mito-targeted AAV
Containing Multiple Mitochondrial Genes:
Expression and Rescue Studies In Mice and
LHON Cells. Hong Yu, H. Yuan, G. S. Gaidosh,
J. Guy. Ophthalmology, Bascom Palmer Eye Inst,
Univ of Miami, Miami, FL
3316 — B0256 Assessment of AAVmediated RHO Augmentation in the Canine
T4R RHO Model of Autosomal Dominant
Retinitis Pigmentosa. Simone Iwabe1, S.
Genini1, R. Sudharsan1, A. S. Lewin2, B. P.
Rossmiller2, W. W. Hauswirth3, G. D. Aguirre1,
W. A. Beltran1. 1Clinical Studies, University
of Pennsylvania, Philadelphia, PA; 2Molecular
Genetics & Microbiology, University of Florida,
Gainesville, FL; 3Ophthalmology, University of
Florida, Gainesville, FL *CR
3302 — B0242 Translational bypass therapy
using ataluren to treat nonsense-mediated
choroideremia. Dhani Tracey-White1, V. De Luca2,
C. Futter1, A. T. Moore1, A. Webster1, M. C. Seabra3,
C. P. Hamel2, V. Kalatzis2, M. Moosajee1. 1Ocular
Biology and Therapeutics, UCL Institute of
Ophthalmology, London, United Kingdom; 2Institut
des Neurosciences de Montpellier, INSERM,
Montpellier, France; 3Molecular Medicine, Imperial
3303 — B0243 Gene Therapy with the
Caspase Activation and Recruitment Domain
(CARD) Reduced Inflammation in the
Endotoxin Induced Uveitis (EIU) Mouse Model.
Cristhian J. Ildefonso1, H. Jaime2, Q. Li3, A. S.
Lewin1. 1Molecular Genetics & Microbiol/Lewin
Lab, Univ of Florida Coll of Medicine, Gainesville,
FL; 2Department of Biology College of Science
and Liberal Arts, University of Florida, Gainesville,
FL; 3Department of Ophthalmology, University of
Florida College of Medicine, Gainesville, FL
3304 — B0244 Gene therapy with selfcomplementary recombinant AAV in models of
autosomal dominant retinitis pigmentosa caused
by RHO mutations. Brian P. Rossmiller, H. Mao,
A. S. Lewin. Genetics, University of Florida,
Gainesville, FL
3305 — B0245 Preclinical Development of AAV
Vectors for the Treatment of X-linked Retinitis
Pigmentosa Caused by RPGR Mutations. Zhijian
Wu, S. Hiriyanna, H. Qian, S. Mookherjee, K.
Kaneshiro, M. M. Campos, R. N. Fariss, T. Li, A.
Swaroop, P. Colosi. NEI/NIH, Bethesda, MD
3306 — B0246 Nuclear expression of human
mitochondrial ND4 gene leads to the protein
assembling in complex I and prevents optic
atrophy and visual loss. Helene CwermanThibault, S. Augustin, C. Lechauve, M. CorralDebrinski. Inserm UMRS-968, Institut de la Vision,
Paris, France
3309 — B0249 Expression of CNGB3 provides
long-term rescue in the cone-only CNGB3 x NRL
double knock-out (DKO) mouse. Seok-Hong Min,
Q. Ruan, S. L. Boye, S. Boye, W. W. Hauswirth,
C. N. Kay. Ophthalmology, University of Florida,
Gainesville, FL *CR
3310 — B0250 A Low Dose AAV Vector
Administration Preserves Cone Function in
an Rp2 Knockout Mouse Model for Retinitis
Pigmentosa. Suddhasil Mookherjee1, P. Colosi1, S.
Hiriyanna1, K. Kaneshiro1, L. Li2, H. Qian1, T. Li1,
H. Khanna2, A. Swaroop1, Z. Wu1. 1National Eye
Institute, National Institute of Health, Bethesda,
MD; 2Department of Ophthalmology, University of
Massachusetts Medical School, Worcester, MA
3311 — B0251 Mutant Human T8993G ATP6
Expression by a Mitochondrial Targeting
Sequence Modification of AAV Capsid VP2 in
Transgenic Mice. Huijun Yuan, J. Guy. Bascom
3312 — B0252 AAV-mediated antisense
oligonucleotide-based therapy for CEP290associated LCA. Alejandro Garanto1, L.
Duijkers1, R. Xiao2, L. H. Vandenberghe2,
R. W. Collin1. 1Human Genetics, Radboud
university medical centre, Nijmegen,
Netherlands; 2Ophthalmology, Schepens Eye
Research Institute, Massachusetts Eye and Ear
Infirmary, Harvard Medical School, Boston,
MA *CR
3313 — B0253 AON intravitreal injections
allows manipulating splicing in retinal cells.
Xavier GERARD, I. Perrault, A. Munnich, J.
Kaplan, J. Rozet. Genetics In Ophthalmology,
Imagine, Paris, France
3314 — B0254 Retinal phenotype in Cln6nclf
mice, a mouse model of neuronal ceroid
lipofuscinoses, amenable to AAV mediated
gene therapy. Sophia Kleine Holthaus1, 2, U.
F. Luhmann1, A. J. Smith1, S. E. Mole2, R. R.
Ali1. 1Department of Genetics, UCL Institute of
Ophthalmology, London, United Kingdom; 2UCL
MRC Laboratory for Molecular Cell Biology,
3317 — B0257 AAV-mediated Gene Therapy
Restores Cone Function in the Cnga3/Nrl
Double Knockout Mouse following intravitreous
injection. Ji-Jing Pang, Y. Tao, W. Du, S. L.
Boye, J. Li, W. Deng, W. W. Hauswirth, S. Boye.
Ophthalmology, University of Florida, Gainesville,
FL *CR
3318 — B0258 AAV-mediated Gene Therapy
Restores M-Cone Function in S-opsin only
Thrb Knockout Mouse. Wei Du1, W. Deng1,
S. L. Boye1, J. Li1, W. Li2, W. W. Hauswirth1, J.
Pang1. 1Ophthalmology, University of Florida,
Gainesville, FL; 2National Eye Institute, NIH,
Bethesda, MD *CR
3319 — B0259 AAV5-mediated gene therapy
rescue cone function in a mouse model of
achromatopsia. Xiaofang Liang2, 1, F. Dong2, 1,
H. Li2, 1, Q. Zhou2, 1, L. Yang2, 1, J. Pang3, R.
Sui2, 1. 1PUMCH, Beijing, China; 2Peking Union
Medical College, Beijing, China; 3University of
3320 — B0260 Tyrosine-mutated AAV2
mediated BDNF gene therapy attenuates retinal
ischemic injuries in rats. Tsutomu Igarashi1, 2,
K. Miyake2, M. Kobayashi1, 2, K. Takahashi1, 2, N.
Miyake2, O. Iijima2, K. Nakamoto1, Y. Hirai2, T.
Shimada2, H. Takahashi1. 1Ophthalmology, Nippon
Medical School, Tokyo, Japan; 2Ophthalmology,
Nippon Medical School, Tokyo, Japan
3321 — B0261 RPGR gene augmentation
delivered at early, mid and late stage disease in
a canine model of XLRP rescues photoreceptor
structure and function. William A. Beltran1, A. V.
Cideciyan2, A. S. Lewin3, S. Iwabe1, M. Swider2,
J. Guzman1, S. L. Boye4, W. W. Hauswirth4, S.
G. Jacobson2, G. D. Aguirre1. 1Clinical Studies,
Univ of Pennsylvania Sch Vet Med, Philadelphia,
PA; 2Ophthalmology, Univ of Pennsylvania Sch
of Med, Philadelphia, PA; 3Molecular Genetics
& Microbiology, Univ of Florida, Gainesville,
FL; 4Ophthalmology, Univ of Florida, Gainesville,
FL *CR
234
3322 — B0262 Using the M013 Myxoma
Virus Gene to Target the Inflammasome in
the Retina. Henrique Jaime1, C. J. Ildefonso1,
M. M. Rahman1, Q. Li2, G. McFadden1, A. S.
Lewin1. 1Molecular Genetics & Microbiology,
University of Florida, Gainesville, FL; 2Department
of Ophthalmology, University of Florida,
Gainesville, FL
3323 — B0263 Diabetes enhances the
efficacy of adeno-associated virus vectors in
rat retina. Nundehui Diaz-Lezama1, Z. Wu2, E.
H. Adan-Castro1, D. Arredondo1, G. Martínez
de la Escalera1, S. Thebault1, P. Colosi3, C.
Clapp1. 1Instituto de Neurobiologia UNAM,
Queretaro, Mexico; 2Ocular Gene Therapy
Laboratory, National Institute of Health, Bethesda,
MD;3BioMarin Pharmaceutical, Inc, Novato, CA
3324 — B0264 Optimization of Clarin-1
AAV Gene Delivery Vectors to the Mouse
Retina. Rachel M. Stupay1, 2, P. Zhu1, W. Deng1,
V. Chiodo1, S. L. Boye1, Q. Li1, W. W. Hauswirth1,
A. Dinculescu1. 1Ophthalmology, University of
Florida, Gainesville, FL; 2Interdisciplinary Program
in Biomedical Sciences, Genetics Concentration,
University of Florida, Gainesville, FL *CR
3326 — B0266 Retinal transduction profiles
by high capacity viral vectors. Agostina Puppo1,
G. Cesi1, E. Marrocco1, A. Auricchio1, 2. 1Telethon
Institute of Genetics and Medicine (TIGEM),
Naples, Italy; 2Medical Genetics, Department of
Translational Medicine, Federico II University,
Naples, Italy
3327 — B0267 Structure Activity Relationships
for a Lead Hammerhead Ribozyme
Therapeutic. Jack M. Sullivan2, 1, M. Zuber1,
T. A. Kolniak2, D. Yu2. 1Research Service, VA
Western New York Healthcare System, Buffalo,
NY; 2Ophthalmology (Ross Eye Institute),
University at Buffalo- SUNY; SUNY Eye Institute,
Buffalo, NY *CR
3328 — B0268 Developing an AAV dual vector
ABCA4 gene therapy treatment for Stargardt
disease. Michelle McClements1, M. S. Singh1,
P. Charbel Issa2, R. E. MacLaren1, 3.1Nuffield
Oxford, Oxford, United Kingdom; 2Department
of Ophthalmology, University of Bonn, Bonn,
Germany; 3Moorfields Eye Hospital, London,
United Kingdom
3329 — B0269 Dual AAV vector development
for CEP290-LCA. Renee C. Ryals, F. M. Dyka, J.
Sun, O. Sroka, W. W. Hauswirth. Ophthalmology,
University of Florida, Gainesville, FL *CR
3331 — B0271 Photoreceptor-Targeted Gene
Delivery Using Intravitreally Administered AAV
Vectors in Dogs. Ryan F. Boyd1, S. L. Boye2, S.
Boye2, W. W. Hauswirth2, A. M. Komaromy1, S.
M. Petersen-Jones1, J. T. Bartoe1. 1Small Animal
Clinical Sciences, Michigan State University,
East Lansing, MI; 2Ophthalmology, University of
3332 — B0272 Efficient gene delivery to
the cone-enriched pig retina by dual AAV
vectors. Pasqualina Colella1, I. Trapani1, G. Cesi1,
A. Sommella1, A. Manfredi1, A. Puppo1, C. Iodice1,
S. Rossi2, M. Giunti3, A. Auricchio1, 4. 1Telethon
Institute of Genetics and Medicine, Naples,
Italy; 2Department of Ophthalmology, Second
University of Naples, Naples, Italy;3Department
of Veterinary Morphophysiology and Animal
Production, University of Bologna, Bologna,
Italy; 4Medical Genetics, Department of
Translational Medicine, Federico II University,
Naples, Italy
3333 — B0273 Assessment of endogenous
silencing of a cone-specific gene (Cnga3)
delivered to rods using an AAV2/5 vector with
CBA promoter. Daniyar Dauletbekov, A. R.
Barnard, M. S. Singh, R. E. MacLaren. Nuffield
Laboratory of Ophthalmology, Oxford University,
Oxford, United Kingdom
3334 — B0274 Design and testing of
AAV vectors for Sod2 gene augmentation
therapy. Manas R. Biswal, Z. Wang, H. Mao, H.
Li, A. Elkaz, A. S. Lewin. Molecular Genetics and
Microbiology, College of Medicine, University of
3335 — B0275 Therapeutic cross-species
efficacy of vectors for human gene therapy in
achromatopsia type 2 (ACHM2). Vithiyanjali
Sothilingam1, R. L. Muehlfriedel1, N. Tanimoto1,
F. Koch2, C. Schön2, M. Garcia Garrido1, S.
C. Beck1, M. Biel2, S. Michalakis2, M. W.
Seeliger1. 1Division of Ocular Neurodegeneration,
Centre for Ophthalmology, Institute for Ophthalmic
Research, Tuebingen, Germany; 2Department of
Pharmacy, Center for Integrated Protein Science
Munich (CIPSM), Center for Drug Research, LMU,
Munich, Germany
3336 — B0276 Optimizing rAAV vectors to
target ON bipolar cells. Miranda L. White1, F.
M. Dyka1, C. N. de Leeuw2, S. Min1, Q. Ruan1,
S. L. Boye1, N. S. Peachey3, 4, E. M. Simpson2,
W. W. Hauswirth1, S. Boye1. 1University of
Florida, Gainesville, FL; 2University of British
Colombia, Vancouver, BC, Canada; 3Cole Eye
Institute, Cleveland Clinic Foundation, Cleveland,
OH; 4Cleveland VA Medical Center, Cleveland,
OH *CR
3337 — B0277 Heparan sulfate affinity dictates
transduction of photoreceptors from the vitreous
by capsid mutated AAV2 variants. Sanford L.
Boye1, A. Bennett2, K. VanVliet2, A. Dinculescu1,
M. L. White1, J. Peterson1, M. Agbandje-McKenna2,
S. Boye1. 1Ophthalmology, University of Florida,
Gainesville, FL; 2Biochemistry and Molecular
Biology, University of Florida, Gainesville, FL
3338 — B0278 Validation of Gene Delivery
in Sheep Ocular Models Towards a Translation
Strategy for Optimization of Human Eye Gene
Therapy. Jacklyn H. Salmon1, M. Hirsch2, 3,
T. Borras2, 3, B. C. Gilger1. 1Clinical Sciences,
North Carolina State University, Raleigh,
NC; 2Ophthalmology, University of North Carolina,
Chapel Hill, NC; 3Gene Therapy Center, University
of North Carolina, Chapel Hill, NC
3339 — B0279 Corneal Gene Therapy:
Magnetofection. Wai Siene Ng1, B. Song2, K.
Binley1, J. E. Morgan1. 1Cardiff Centre for Vision
Sciences, Cardiff University, Cardiff, United
Kingdom; 2School of Dentistry, Cardiff University,
Cardiff, United Kingdom
3340 — B0280 Safety, local tolerability
and biodistribution of GS010 (AAV2/2ND4), a gene therapy medicinal product in
development for Leber Hereditary Optic
Neuropathy (LHON). Nitza Thomasson1, H.
Cwerman-Thibault2, S. Augustin2, M. Simonuti2,
J. Sahel2, D. Pruneau1, M. Montus3, A. Galy1,
M. Corral-Debrinski2. 1GenSight Biologics,
Paris, France;2Institut de la Vision, Paris,
France; 3Genethon, Evry, France *CR
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Multidisciplinary Ophthalmic Imaging / Retinal
Cell Biology / Retina
343 OCT imaging - Clinical studies
of choroid
Moderator: Francine F. Behar-Cohen
3341 — C0034 Exploring retinal-choroidal
characteristics using Swept Source-OCT
in healthy and highly myopic eyes. Daniele
De Geronimo, M. Parravano, F. Oddone, M.
Sciamanna, A. Boninfante, P. Giorno, P. Cosimi,
M. Varano. Medical Retina Unit, Fondazione
G.B.Bietti-IRCCS, Rome, Italy *CR
3342 — C0035 Choroidal Thickness In
Healthy Hispanic Subjects Measured By
Enhanced Depht Imaging Optical Coherence
Tomography. Carolina Sardi Correa1, 2, C.
Acosta1, 2, J. Sanchez1, 2, A. Rodriguez2, A.
Gutierrez2. 1INIO, Medellin, Colombia; 2CLOFAN,
Medellin, Colombia
3343 — C0036 Age Related Choroidal Atrophy
in Hispanics. Daniel Janer, C. Acosta, C. Sardi, J.
Sanchez, J. Pelaez. INIO, Medellin, Colombia *CR
235
Tuesday Posters
11:00 am – 12:45 pm
3325 — B0265 The utility of AAV2/rh10 for
gene delivery to murine photoreceptors. Arpad
Palfi1, N. Chadderton1, S. Millington-Ward1,
M. O’Reilly1, J. Bennett2, P. Kenna1, J.
Farrar1. 1Genetics, Trinity College Dublin, Dublin,
Ireland; 2F. M. Kirby Center for Molecular
Ophthalmology, Philadelphia, PA *CR
3330 — B0270 Characterization of fidelity of
dual Adeno-associated virus vectors generated
cDNA. Frank M. Dyka, S. L. Boye, W. W.
Hauswirth, S. Boye. Ophthalmology, University of
3344 — C0037 Differences in choroidal
thickness assessment between Cirrus and
Spectralis optical coherence tomography
devices. Pablo Hernandez-Martinez1, I. PascualCamps1, F. Esteve2, A. Lleo_Perez3, R. MarcoDolz1, R. Gallego-Pinazo1. 1Ophthalmology,
University and Polytechnic Hospital La Fe, Paterna,
Spain; 2Ophthalmology, Centro Hospitalar de
Entre o Douro e Vouga, Santa Maria da Feira,
Portugal; 3Ophthalmology, University of Valencia,
Valencia, Spain *CR
3345 — C0038 Choroidal thickness derived
from full-volume segmentation: Comparison
of spectral-domain OCT with enhanced depth
imaging versus 1050nm swept source OCT. AnaMaria Glodan, S. M. Waldstein, B. Gerendas, H.
Faatz, C. Simader, U. Schmidt-Erfurth. ChristianDoppler-Laboratory for Ophthalmic Image
Analysis, Vienna Reading Center, Department of
Ophthalmology, Medical University of Vienna,
Vienna, Austria *CR
Tuesday Posters
11:00 am – 12:45 pm
3346 — C0039 Inter-observer and inter-device
agreement in choroidal and scleral thickness
measurement between Spectralis and Atlantis
OCT systems. Fred K. Chen1, 2, E. Wong1, 2. 1Centre
for Ophthalmology & Visual Science, The
University of Western Australia, Perth, WA,
Australia; 2Lions Eye Institute, Perth, WA, Australia
3347 — C0040 A comparative analysis
of choroidal thickness map in healthy eyes
using spectral domain optical coherence
tomography and swept source optical coherence
tomography. Byung Ro Lee, Y. Shin, H. Lim, S.
Lee. Ophthalmology, Hanyang Univ Hosp, Seoul,
3348 — C0041 Spectral Domain OCT
Choroidal and Macular Thickness Evaluation
in Primary and Secondary Raynaud’s
Phenomenon. Luisa Pierro1, C. Del Turco1,
F. Ingegnoli2, E. Miserocchi1, M. Gagliardi1,
G. Modorati1, F. Bandello1. 1Ophthalmology,
San Raffaele Scientific Institute, Milan,
Italy; 2Rheumatology, G. Pini Institute, Milan,
Italy *CR
3349 — C0042 Morphology and Vascular
Layers of the Choroid in Stargardt’s Disease
Analyzed Using Spectral Domain Optical
Coherence Tomography. Sarah Read1, 2, M. Adhi1,
D. Ferrara1, J. S. Duker1, N. K. Waheed1. 1New
England Eye Center, Tufts Medical Center, Boston,
MA; 2Bascom Palmer Eye Institute, Miami, FL *CR
3350 — C0043 Choroidal Thickness
in Nonarteritic Anterior Ischemic Optic
Neuropathy: a Study with Optical Coherence
Tomography. Arnaldo D. Santos1, R. Anjos1,
A. Vicente1, A. Cabugueira1, B. Borges1, M.
Cardoso1, L. vieira1, J. Ferreira1, R. Flores1, 2, J. P.
Cunha1, 2. 1Ophthalmology, Centro Hospitalar de
Lisboa Central, Lisbon, Portugal; 2Faculdade de
Ciências Médicas da Universidade Nova de Lisboa,
Lisboa, Portugal
3351 — C0044 Evaluation Of Choroidal
Thickness Using Oct Method, In Patients With
Systemic Arterial Hypertension. Lana Pelaes, R.
L. dos Santos, G. Meireles, P. Lopes, L. Almeida
Fernandes, A. Rosa. Ophthalmology, Universidade
Federal Do Para, Belem, Brazil
3352 — C0045 Central Choroidal Thickness
Measured By Enhanced Depht Imaging Oct
In Fellow Eyes Of Subjects With Central
Serous Chorioretinopathy. Juan Sanchez1, 2, C.
Acosta1, 2, C. Sardi2, 1, J. Gil2, 1. 1INIO, Medellin,
Colombia; 2CLOFAN, Medellin, Colombia
3353 — C0046 Evaluation of choroidal
thickness by SD-OCT and Enhanced Depth
Imaging in patients with chronic central serous
chorioretinopathy (CSC) and their relatives.
Mathieu Lehmann, M. Zhao, A. P. Brezin, F. F.
Behar-Cohen. Hotel Dieu de Paris, Paris cedex 04,
France
3354 — C0047 Multimodal Imaging and the
Effect of Half-fluence PDT on Choroidal Volume
in Central Serous Chorioretinopathy. Dina
Baddar1, 2, M. R. Munk1, 3, R. Shah1, B.
Wong1, F. Pappas1, S. Khan1, L. M. Jampol1,
A. A. Fawzi1. 1Ophthalmology, Northwestern
University, Feinberg School of Medicine, Chicago,
IL; 2Ophthalmology, Al Watany Eye Hospital,
Cairo, Egypt; 3Ophthalmology, Medical University
Vienna, Vienna, Austria
3355 — C0048 Utility of SDOCT as a
complimentary tool during ocular screening.
Marina Kogut, S. Blazier, B. Szirth, A. S. Khouri.
The Institute of Ophthalmology and Visual Science,
Rutgers New Jersey Medical School, Newark,
NJ *CR
3356 — C0049 Optical Coherence
Tomography Of The Optic Nerve Database
Of An Amazonian Population. Lucas Daniel
Almeida Fernandes1, 2, G. Meireles1, 2, R. L.
dos Santos1, 2, P. Lopes1, 2, P. Rabelo Paixao1, 2,
L. Botelho Vergara1, 2, E. B. Lacerda1, 3, G. S.
Souza1, 3, A. Rosa2, 4, L. L. Silveira1, 3. 1Nucleo
de Medicina Tropical, Universidade Federal do
Para, Belem, Brazil; 2Instituto de Ciencias da
Saude, Universidade Federal do Para, Belem,
Brazil; 3Instituto de Ciencias Biologicas,
Universidade Federal do Para, Belem,
Brazil; 4Hospital Universitario Bettina Ferro de
Souza, Universidade Federal do Para, Belem, Brazil
3357 — C0050 Feasibility of Intrasurgical
Assessment of Submacular tPA injection
for Submacular Hemorrhage Utilizing
Intraoperative OCT. Daniel Petkovsek1, 2,
S. K. Srivastava2, A. Yuan2, R. P. Singh2, J. P.
Ehlers2. 1Case Western Reserve University School
of Medicine, Cleveland, OH; 2Ophthalmic Imaging
Center. Vitreoretinal Service. Cole Eye Institute,
Cleveland Clinic, Cleveland, OH *CR
3358 — C0051 Postmortem Ultrasound and
OCT Imaging of the Posterior Segment. Peter R.
Pavan1, M. D. McCartney2, T. Saunders1, P. Gore2,
N. Sprehe2, W. Saxon1, C. E. Margo1. 1Eye Institute,
University of South Florida, Tampa, FL; 2Ocular
Research Center, Lions Eye Institute for Transplant
& Research, Tampa, FL
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Multidisciplinary Ophthalmic Imaging / Retinal
Cell Biology / Retina
344 OCT imaging - Clinical studies
of retina
Moderator: Thomas R. Hedges
3359 — C0052 A comparison of image
quality between swept source optical coherence
tomography and spectral domain optical
coherence tomography according to ocular
media opacity. Yong Un Shin, B. Lee, H. Lim.
Ophthalmology, Hanyang Medical Center, Seoul,
3360 — C0053 Combined depth imaging
(CDI) technique on Heidelberg Spectralis
versus Topcon DRI Swept Source (SS)
OCT in full-depth visualization of macular
structures. Giulio Barteselli1, 2, D. G. Bartsch1,
J. T. Nezgoda1, N. Camacho1, A. Marvasti1, R.
N. Weinreb1, W. R. Freeman1. 1Ophthal-Jacobs
Retina Ctr, Univ of California San Diego, La Jolla,
CA;2Ophthalmology, University of Milan, Milan,
Italy
3361 — C0054 Correlation between the
Position of Retinal Nerve Fiber Layer Peak
and the Position of Retinal Major Vessels in
Healthy Korean Eyes. Seungsoo Rho1, 4, C. Park2,
Y. Sung1, W. Song1, S. Rho3, H. Bae4, S. Lee4, C.
Kim4. 1Ophthalmology, CHA Bundang Medical
Center, CHA University, Seongnam, Republic
of Korea; 2Center for Program Analysis and
Evaluation, Security Management Institute, Seoul,
Republic of Korea; 3Ophthalmology, Dong-A
of Korea; 4Institute of Vision Research, Department
of Ophthalmology, Yonsei University College of
Medicine, Seoul, Republic of Korea
3362 — C0055 Optical Coherence Tomography
(OCT) Use in Assessing Hydrocephalus. Marisa
Gobuty1, T. R. Hedges2, G. K. Athappilly2, S.
Hwang2. 1Tufts University School of Medicine,
Boston, MA; 2Departments of Neurology,
Neurosurgery, Ophthalmology, Tufts Medical
Center, Boston, MA
236
3363 — C0056 Utility of Automated Ganglion
Cell Layer Analysis by Spectral Domain
Optical Coherence Tomography in Chiasmal
Compression. Joseph Ho, C. E. MendozaSantiesteban, G. K. Athappilly, T. R. Hedges.
Department of Ophthalmology, Tufts-New England
Eye Center, Boston, MA
3364 — C0057 Imaging amyotrophic lateral
sclerosis (ALS) neurodegeneration through the
eye. Nisha Mukherjee1, A. N. Kuo1, R. Bedlack2,
H. Tseng1. 1Ophthalmology, Duke University Eye
Center, Durham, NC; 2Neurology, Duke University
Medical Center, Durham, NC *CR
3365 — C0058 Macular and retinal
degeneration in Alzheimer’s disease. Joao-Paulo
Cunha1, A. D. Santos1, J. Ferreira1, D. Amado1, C.
Louro3, C. Dinis2. 1Centro Hospitalar de Lisboa
Central, Lisbon, Portugal; 2Faculdade de Medicina
de Lisboa, Lisboa, Portugal; 3Faculdade de Ciências
Médicas de Lisboa, Lisboa, Portugal
3366 — C0059 Sensitivity and Specificity of
Fluorescence and Polarimetry of the Retina
in Alzheimer’s Disease. Laura Emptage1, M.
L. Kisilak1, 2, M. Wilson1, Z. Leonenko1, 3, M. C.
Campbell1, 2. 1Physics and Astronomy, University
of Waterloo, Waterloo, ON, Canada; 2School
of Optometry and Vision Science, University
of Waterloo, Waterloo, ON, Canada;3Biology,
University of Waterloo, Waterloo, ON, Canada *CR
3368 — C0061 Spectral Domain Optical
Coherence Tomography of Ganglion Cell
Complex and Retinal Nerve Fiber Layer in
Multiple Sclerosis. Silvia Calafiore, G. Scuderi, F.
Martino, G. Ducoli, M. Delle Fave, A. Perdicchi.
NESMOS, Sapienza University of Rome, Rome,
Italy
3369 — C0062 Optical coherence tomography
in the diagnosis and management of agerelated macular degeneration. Christine
M. Schmucker1, G. Virgili2, G. Ruecker3, H.
Agostini4, C. Ehlken4. 1German Cochrane Center,
University Medical Center Freiburg, Freiburg,
Germany; 2Department of Ophthalmology,
University of Florence, Florence, Italy;3Department
of Medical Biometry and Statistic, University
Medical Center Freiburg, Freiburg,
Germany; 4University Eye Hospital, University
Medical Center Freiburg, Freiburg, Germany
3371 — C0064 Retinal and choroidal
thickness: comparison of two non-contact optical
biometers in young adults. Bjorn Drobe1, 2, J.
Bao3, 2, K. Chen3, 2, H. Chen3, 2. 1R&D Asia, Essilor
International, Wenzhou, China; 2WEIRC (WMUEssilor International Research Center), Wenzhou,
China; 3School of Ophthalmology and Optometry,
Wenzhou Medical University, Wenzhou, China *CR
3372 — C0065 Abnormalities in Retinal
Structure in Diabetics with Minimal or no
Retinopathy Assessed by SD-OCT. Andrew W.
Francis, J. McAnany, J. Wanek, J. C. Park, J. I. Lim,
M. Shahidi. Ophthalmology and Visual Sciences,
University of Illinois Eye and Ear Infirmary,
Chicago, IL
3373 — C0066 Identifying progression
of retinal disease in eyes with mild NPDR
in diabetes type 2 using non-invasive
procedures. Catarina Neves. CORC - Coimbra
Ophthalmology Reading Center, AIBILI Association for Innovation and Biomedical
Research on Light and Image, Coimbra, Portugal f
3374 — C0067 Subclinical macular OCT
changes in type I diabetic patients. Kacy
Richmond, E. S. Crane, B. Szirth, A. S. Khouri,
S. Blazier. Institute of Ophthalmology and Visual
Science, Rutgers New Jersey Medical School,
Newark, NJ *CR
3375 — C0068 Optovue RTVue Retinal
Thickness Reproducibility and Conversion to
Stratus Metrics in DME. Paul A. Edwards. Dept of
Ophthal and Eye Care Services, Henry Ford Health
System, Detroit, MI
3376 — C0069 Comparison of central retinal
thickness and outer retina integrity in relation
to visual acuity using two different OCT devices
in diabetic macular edema.Veronica A. Kon Jara1,
B. Buck1, G. Lopezcarasa2, M. Landers1. 1Retina,
University of North Carolina at Chapel Hill, Chapel
Hill, NC; 2Ophthalmology, Hospital Angeles,
Mexico D.F., Mexico
3377 — C0070 Quantitative image analysis
applied to the grading of vitreous haze. Brian
Madow1, E. Greenberg1, D. W. Richards1, C. L.
Passaglia2, 1. 1Ophthalmology, University of South
Florida, Tampa, FL; 2Chemical & Biomedical
Engineering, College of Engineering, USF,
Tampa, FL
3378 — C0071 Correlation between visual
acuity and morphologic subtypes of diabetic
macular edema based on a new clinical
grading protocol (SAVE). Matthias Bolz, J.
Pretzl, N. Klaida, S. Priglinger. Department of
Ophthalmology, General Hospital Linz, Linz,
Austria
3379 — C0072 Optical Coherence
Tomography of the Central Retina in Pediatric
Patients with Usher Syndrome. Vincensa
Mucaj1, E. A. Swanson1, J. Tavormina1, R. M.
Hansen1, 2, A. Moskowitz1, 2, J. D. Akula1, 2, A.
Fulton1, 2. 1Ophthalmology, Boston Children,
Boston, MA; 2Harvard Medical School, Boston, MA
3380 — C0073 Area Measurement of the
Ellipsoid Zone (EZ) by SD-OCT and its
Correlation with Visual Field Identifies a
Potential Anatomical Endpoint for Clinical Trials
in Retinitis Pigmentosa (RP). Alexander Ho1, T.
Smith2, A. Hariri1, E. Chegarnov2, F. L. Ferris3, P.
Van Veldhuisen4, S. R. Sadda1, 6, R. G. Weleber2,
D. G. Birch5. 1Doheny Image Reading Center,
Doheny Eye Institute, Los Angeles, CA; 2Casey
Eye Institute, Oregon Health & Science University,
Portland, OR; 3Division of Epidemiology and
Clinical Applications, National Eye Institute/
National Institutes of Health, Bethesda,
MD; 4The EMMES Corporation, Rockville,
MD; 5Retina Foundation of the Southwest,
Dallas, TX; 6Department of Ophthalmology, Keck
California, Los Angeles, CA *CR, f
3381 — C0074 Quantification of the Structure
of the Perifoveal Retina in Retinopathy of
Prematurity. Emily A. Swanson1, J. Tavormina1, T.
L. Favazza1, A. Moskowitz1, 2, R. M. Hansen1, 2, J.
D. Akula1, 2, A. Fulton1, 2. 1Ophthalmology, Boston
Children’s Hospital, Boston, MA; 2Ophthalmology,
3382 — C0075 Aniridia and reduction in nerve
fiber layer: Quantitative analysis using SDOCT. Rebecca Lindsay, J. P. Kelly, A. H. Weiss.
Ophthalmology, University of Washington, Seattle,
WA
3383 — C0076 Structural Findings in Carriers
and Affected Individuals with Choroideremia an Optical Coherence Tomography Study. Daniel
C. Chung, J. I. Morgan, E. S. Charlson, J. Bennett,
A. M. Maguire. FM Kirby Ctr Molecular Ophth,
Scheie Eye Institute, Philadelphia, PA *CR
3384 — C0077 En Face OCT imaging
of Retinal Astrocytic Hamartoma in 13
cases. Eleonora Benedetta Marcheggiani1, C.
Veronese2, L. Urbini1, F. Tassi1, A. Finzi1, M.
Morara2, A. P. Ciardella2. 1Ophthalmolgy Unit,
University of Bologna, S. Orsola-Malpighi
Hospital, Bologna, Italy; 2Ophthalmology Unit, S.
Orsola-Malpighi Hospital, Bologna, Italy
237
Tuesday Posters
11:00 am – 12:45 pm
3367 — C0060 Optical properties of the
human retina as a window into systemic and
brain diseases. Rui Bernardes1, 3, A. Correia1,
O. C. d’Almeida2, 3, S. Batista4, L. Sousa4, M.
Castelo-Branco2, 3. 1CNTM - Centre of New
Technologies for Medicine, AIBILI - Association
for Innovation and Biomedical Research in Light
and Image, Coimbra, Portugal; 2ICNAS, University
of Coimbra, Coimbra, Portugal; 3IBILI - Institute
for Biomedical Imaging and Life Sciences, Faculty
of Medicine, University of Coimbra, Coimbra,
Portugal; 4University Hospital of Coimbra,
Coimbra, Portugal
3370 — C0063 Segmentation Error versus
Decentration Error of SDOCT Volume Scans
in Eyes with Neovascular Age-related Macular
Degeneration. Lisa A. Engel1, T. Ristau1, N. F.
Mokwa1, A. Walsh3, B. Kirchhof1, S. R. Sadda2, S.
Liakopoulos1. 1Center of Ophthalmology, University
Hospital of Cologne, Cologne, Germany; 2Doheny
Image Reading Center, Doheny Eye Institute, Los
Angeles, CA; 3Department of Ophthalmology, Keck
California, Los Angeles, CA *CR
Coherence Tomography and Fundus
Autofluorescence in Patients with Rubella
Retinopathy. Chad Hummel, S. Grover.
Ophthalmology, Univeristy of Florida College of
Medicine - Jacksonville, Jacksonville, FL
3386 — C0079 Microperimetric study,
multifocal erg,spectral domain optical coherence
tomography in 8 children with best syndrom
(vitelliform macular distrophy type 2 gene
VMD2, 11q13). Sergio Zaccaria Scalinci, L. V.
Scorolli. Ophthalmology, University of Bologna
SOrsola Malpighi, Bologna, Italy
3387 — C0080 Extension of alteration of
retinal neurosensory layers in central retinal
artery occlusion. Silja Bairov1, P. Ackermann1,
M. Brachert1, D. Finis1, P. Albrecht2, G. Geerling1,
O. Aktas2, R. Guthoff1. 1Ophthalmology,
Heinrich-Heine University Düseldorf, Düsseldorf,
Germany; 2Neurology, Heinrich-Heine-Universität,
Düsseldorf, Germany
Tuesday Posters
11:00 am – 12:45 pm
3388 — C0081 A transient additional
band in SD-OCT observed in acute retinal
ischemic conditions. Nikolaus Feucht, F.
Heine, C. Lohmann, M. M. Maier, I. M.
Lanzl. Ophthalmology, TU Munich, Munich,
Germany *CR
3389 — C0082 The Prognostic Role of
Microcystic Macular Changes in Patients
with Retinal Vein Occlusions Treated with
Ranibizumab. Matus Rehak, M. Tuisl, P. M.
Wiedemann. Department of Ophthalmology,
University of Leipzig, Leipzig, Germany *CR
3390 — C0083 Optical Coherence Tomography
Findings in Retinal Artery Occlusion. Richard
M. Feist1, 2, J. O. Mason1, 2, M. L. Thomley1, 2, M.
A. Albert1, 2, C. M. Ayala1.1Retina Consultants of
Alabama, Birmingham, AL; 2Ophthalmology, UAB,
Birmingham, AL
3391 — C0084 Distinctive Pattern Of Ganglion
Cell Layer Loss In Early Ischemic Optic
Neuropathy. Carlos E. Mendoza-Santiesteban1, 2,
N. Patel1, C. Monaco1, T. R.
Hedges1.1Ophthalmology - New England Eye
Center, Tufts Medical Center. Tufts University,
Boston, MA; 2Neurology - Dysautonomia Center,
NYU Medical Center. New York University, New
York, NY
3392 — C0085 Comparison of optic nerve
parameters in children with high hyperopia
and emmeropia measured with HRT II and
OCT. Yaroslava Wenner, V. Brauer, A. Lazaridis,
T. Bertelmann, W. Sekundo. Ophthalmology,
University Hospital Marburg, Marburg, Germany
3393 — C0086 Ganglion Cell Layer Analysis
in Patients with Optic Disc Hemorrhage. George
J. Parlitsis, E. Chung, N. M. Radcliffe. Department
of Ophthalmology, Weill Cornell Medical College,
New York, NY
Coherence Tomographic Analysis Of The Ocular
Equator. Mariana Harasawa1, G. Salcedo1, 2,
M. Paciuc-Beja1, 2, M. T. Mathias2, 1, R. VelezMontoya2, J. L. Olson2, S. C. Oliver2, N. Mandava2,
H. Quiroz-Mercado1, 2. 1Ophthalmology, Denver
Health Medical Center, Denver, CO; 2Rocky
Mountain Lions Eye Institute, University of
Colorado School of Medicine, Aurora, CO
3395 — C0088 Evaluation of Optical
Coherence Tomography in Patients
with Vigabatrin Toxicity Identified by
ERG. Ananthavalli Kumarappah1, C. A. Westall1, 2,
A. Reginald2, R. Buncic2. 1Institute of Medical
Canada; 2Ophthalmology and Vison Sciences,
The Hospital for Sick Children, Toronto, ON,
Canada *CR
3396 — C0089 Functional and structural
outcomes in the Posner-Schlossman
syndrome. Sonia Valsero Franco, S. Pinar, J.
Artaraz, B. Jiménez Gómez, M. GonzalezMontpetit, A. Orive, A. Fonollosa. Oftalmologia,
Hospital universitario de cruces, Bilbao, Spain
3397 — C0090 Hypotheses about the Identity
of Outer Retinal Microstructure in OCT
Cross-sections and Quantitative Measurements
in Normal Subjects. Artur V. Cideciyan, A.
Sumaroka, S. G. Jacobson. Dept of Ophthalmology,
Scheie Eye Institute, Univ of Pennsylvania,
Philadelphia, PA
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Retina / Multidisciplinary Ophthalmic Imaging
345 Posterior Segment Imaging
Moderators: Jost B. Jonas and Ron A. Adelman
3398 — C0091 Hyper-Autofluorescent
Ring in Neovascular Age-Related Macular
Degeneration. Natalia Camacho1, 2, G.
Barteselli1, 2, L. Cheng1, 2, D. G. Bartsch1, 2, W. R.
Freeman1, 2. 1Ophthalmology, UCSD Shiley Eye
Center, La Jolla, CA; 2Ophthalmology, UCSD
Jacobs Retina Center, La Jolla, CA *CR
3399 — C0092 Changes in Fundus
Autoflourescence After Intravitreal Anti-VEGF
according to the Type of Neovascular AgeRelated Macular Degeneration. Jiyoung Lee, H.
Lee, H. Chung, H. Kim. ophthalmology, Konkuk
university hospital, Seoul, Republic of Korea
3400 — C0093 Outer Retinal Corrugations in
Age-related Macular Degeneration. Sotaro Ooto1,
S. Vongkulsiri1, T. Sato1, M. Suzuki1, C. A. Curcio2,
R. F. Spaide1. 1VRM consultants of New York, New
York, NY; 2Ophthalmology, EyeSight Foundation of
Alabama Vision Research Laboratories, University
of Alabama School of Medicine, Birmingham,
Birmingham, AL *CR
3401 — C0094 Outer Retinal Tubulation
observed with SDOCT and AOSLO. Brett King,
K. Sapoznik, A. E. Elsner, T. Gast, S. A. Burns.
Optometry, Indiana University, Bloomington, IN
3402 — C0095 Assessment of retinal structures
in eyes with active and resolved neovascular age
related macular degeneration. Mostafa S. Hanout,
N. Rajagopalan, M. A. Sadiq, K. E. Guinn, M.
Ibraheem, S. Sarwar, J. Maya, D. V. Do, Q. Nguyen,
Y. Sepah. Ocular Imaging Research and Reading
Center, Stanley M. Truhlsen Eye Institute, Omaha,
NE *CR
3403 — C0096 Structural changes of choroidal
neovascularization in indocyanine green
angiography after intravitreal ranibizumab
injection. Hyun Woong Kim1, 4, J. E. Lee2, 3, S. Lee5,
J. Lee1, 6, I. Yun1, 4. 1Ophthalmology, Inje University,
Busan, Republic of Korea; 2Ophthalmology,
Pusan National University, Yangsan, Republic
of Korea; 3Medical Institute, Pusan National
University Hospital, Busan, Republic of
Korea; 4Ophthalmology, Busan Paik Hospital,
Busan, Republic of Korea; 5Ophthalmology, Gospel
hospital, College of medicine, Kosin university,
Busan, Republic of Korea; 6Ophthalmology,
Haeundae Paik Hospital, Busan, Republic of
Korea *CR, f
3404 — C0097 Angiographic and Tomographic
Characterization of Intermediate Agerelated Macular Degeneration. Ga Eun Cho1,
S. Kang1, S. Chung1, S. Kim1, J. Kim2, M.
Kong1. 1Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Republic of Korea; 2Ophthalmology, Kim’s
Eye Hospital, Myung-Gok Eye Research Institute,
Konyang University College of Medicine, Seoul,
Republic of Korea
3405 — C0098 Correlation of visual acuity with
subretinal versus subretinal pigment epithelium
location of subfoveal fibrovascular scars in wet
age-related macular degeneration. Christina
Ryu, S. Alhumaid, A. Rosen, J. Galic, J. Chen, D.
Kalache. McGill University, Montreal, QC, Canada
3406 — C0099 Grey hyper-reflective subretinal
exudative lesions in wet age-related macular
degeneration. Raphaelle Ores, N. Puche, G.
Querques, R. Blanco-Garavito, B. Merle, G. J.
Coscas, H. Oubraham, O. Semoun, E. H. Souied.
Ophtalmology, Centre Hospitalier Intercommunal
de Creteil, Creteil, France *CR
3407 — C0100 First signs of neovascular
age-related macular degeneration requiring
anti-VEGF treatment in second eyes under
monthly surveillance after treatment in the
first eye. Shokufeh Tavassoli, M. Buckle, A. A.
Sallam, R. Johnston. Ophthalmology Department,
Gloucestershire Hospitals,NHS Foundation Trust,
Gloucestershire, United Kingdom
238
3408 — C0101 Fast Fluid Detection in 3-D
Macular OCT Scans. Gwenole Quellec1, L.
Eberhard1, 3, P. A. Dufour1, 2, S. Wolf2, J. H.
Kowal1, 2. 1Ophthalmic Technologies ARTORG
Center, University of Bern, Bern, Switzerland;
2
Department of Ophthalmology, University of Bern,
Bern, Switzerland; 3Ecole Polytechnique Fédérale
de Lausanne, Lausanne, Switzerland *CR
3414 — C0107 Choroidal thickness at various
sites during head-down tilt. Ari Shinojima1, 2,
M. Yuzawa1. 1Ophthalmology, Surugadai Nihon
University Hospital, Chiyoda-ku, Japan; 2Aerospace
and Environmental Medicine, Nihon University
Graduate School Department of Social Medicine,
Division of Hygiene, Nihon University School of
Medicine, Itabasi-ku, Japan
3409 — C0102 5-line Raster versus
MAP(volumetric) images in Optical Coherence
Tomography(OCT) imaging for the detection
of fluid in exudative Age-Related Macular
Degeneration(AMD). April Harris. Retina
Associates, Tucson, AZ
3415 — C0108 Choroidal Thickness During
Brief Periods of Accommodation in Normal
Eyes. Ella H. Leung, P. Garcia, R. B. Rosen.
Department of Ophthalmology, New York Eye &
Ear Infirmary, New York, NY
3410 — C0103 Ultra Wide Field
Autofluorescence Imaging in Age Related
Macular Degeneration- Optos Peripheral Retina
(OPERA) Age Related Eye Disease Study 2
(AREDS2) Ancillary Study. Amitha Domalpally1,
R. P. Danis1, E. Y. Chew2, S. R. Sadda4, T. E.
Clemons3, T. R. Friberg5. 1Ophthalmology,
Fundus Photograph Reading Center, Madison,
WI; 2National Eye Institute, Bethesda, MD; 3Emmes
Corporation, Rockville, MD; 4Doheney Eye
Institute, Los Angeles, CA; 5UPMC Eye Center,
Pittsburgh, PA f
3412 — C0105 En Face Imaging of the
Choroid in Diabetic Retinopathy using SweptSource Optical Coherence Tomography. Tarek
Alasil1, D. Ferrara1, M. Adhi1, M. F. Kraus2, C. R.
Baumal1, A. J. Witkin1, J. J. Liu3, J. G. Fujimoto3,
N. K. Waheed1, J. S. Duker1. 1Ophthalmology,
New England Eye Center, Boston, MA; 2Pattern
Recognition Lab and SAOT, University Erlangen
Nuremberg, Erlangen, Germany; 3Electrical
Engineering and Computer Science, Massachusetts
Institute of Technology, Cambridge, MA *CR
3413 — C0106 Characterization of Choroidal
Layers in Normal Eyes with En Face SweptSource Optical Coherence Tomography. Daniela
Ferrara1, M. Adhi1, C. R. Baumal1, T. Alasil1, J. J.
Liu2, K. Mohler2, J. Hornegger3, J. G. Fujimoto2, J.
S. Duker1, N. K. Waheed1. 1Ophthalmology, New
England Eye Center, Tufts University, Boston,
MA; 2Department of Electrical Engineering and
Computer Science and Research Laboratory of
Electronics, Massachusetts Institute of Technology,
Cambridge, MA; 3Pattern Recognition Lab and
Graduate School in Advanced Optical Technologies,
University Erlangen-Nuremburg, ErlangenNuremburg, Germany *CR
3417 — C0110 Assessment Of Choroidal
Thickness Before And After Hemodialysis In
Patients With And Without Diabetes. Akihiro
Ishibazawa1, 2, T. Nagaoka1, Y. Minami2, A.
Yoshida1. 1Ophthalmology, Asahikawa Medical
University, Asahikawa, Japan; 2Ophthalmology,
Nayoro City General Hospital, Nayoro, Japan
3418 — C0111 Choroidal blood flow and
thickness in normal eyes. Kanae Arai, I. Maruko,
A. Kogure, A. Tamura, M. Kimura, H. Koizumi,
T. Iida. Ophthalmology, Tokyo women medical
university, Shinjyuku-ku, Japan
3419 — C0112 Friedman lipid globules in
human choroid, revisited. Jay Glover, J. D.
Messinger, C. A. Curcio. Ophthalmology, UAB,
Birmingham, AL
3420 — C0113 Longitudinal Optical Density
Measurements of Subretinal Fluid Pockets After
Surgical Repair of Rhegmatogenous Retinal
Detachment. Albert Y. Cheung1, A. H. Kashani2,
J. Robinson3, G. A. Williams3. 1Department
of Ophthalmology, Beaumont Health System,
Royal Oak, MI; 2Department of Ophthalmology,
University of Southern California, Los Angeles,
CA; 3Associated Retinal Consultants P.C., Royal
Oak, MI
3421 — C0114 Spectral domain optical
coherence tomography and fundus
autofluorescence of persistent submacular fluid
after surgery for retinal detachment. Joshua
Fernandes, D. S. Grewal, A. T. Lyon, M. Gill.
Ophthalmology, Northwestern University,
Chicago, IL
3423 — C0116 Classification of Diabetic
Macular Edema Based on the Morphology in
Optical Coherent Topography. Andrew Want,
R. Rewbury, R. Varughese, V. Chong. Oxford Eye
Hospital, Oxford, United Kingdom
3424 — C0117 Optical coherence tomographic
findings of nonperfusion areas in diabetic
retinopathy. Tomoaki Murakami, A. Uji, N.
Unoki, S. Yoshitake, Y. Dodo, N. Yoshimura.
Ophthalmology & Visual Sciences, Kyoto Univ
Grad Sch of Med, Kyoto, Japan
3425 — C0118 Using optical coherence
tomography to distinguish intraretinal
microvascular abnormalities from neovascular
complexes in diabetic retinopathy. Hemal Mehta1,
D. A. Sim2, 1, P. A. Keane2, 1, J. Zarranz-Ventura1,
M. Fruttiger2, C. A. Egan1, A. Tufail1, 2. 1Medical
Retina, Moorfields Eye Hospital, London, United
Kingdom; 2Institute of Ophthalmology, University
College of London, London, United Kingdom
3426 — C0119 Analysis of morphologic
changes and treatment prognosis in intraretinal
cystoid diabetic macular edema using SD-OCT.
Ei Tae Kim, J. Heo. Ophthalmology, Seoul national
3427 — C0120 Segmentational Diurnal
Analysis of Retinal Thickness in Diabetic
Macular Edema with Spectral-domain Optical
Coherence Tomography. Min Sagong.1yeungnam
univeristy medical center, Daegu, Republic of
Korea; 2Yeungnam university medical center,
Daegu, Republic of Korea
3428 — C0121 Detection of peak fundus
autofluorescence (FAF) signals and
hyperautofluorescent spots using confocal
scanning laser ophthalmoscope (cSLO) with
30° and 55° lenses. Teresa S. Tee1, 2, I. Murray2, T.
Aslam3, I. Leung1, 2. 1Experimental Optometry Lab,
University of Manchester - Singapore Polytechnic,
Singapore, Singapore; 2Vision Sciences Lab,
University of Manchester, Manchester, United
Kingdom; 3Research Centre, Manchester Royal Eye
Hospital, Manchester, United Kingdom
3429 — C0122 Reproducibility of hard
exudate quantification in diabetic retinopathy
using polarization sensitive optical coherence
tomography with retinal tracking. Mitsuro
Sugita1, 3, S. Zotter1, M. Pircher1, P. K. Roberts2, S.
G. Prager2, T. Makihira3, N. Tomatsu3, M. Sato3,
U. Schmidt-Erfurth2, C. K. Hitzenberger1. 1Center
for Medical Physics & Biomed.Eng., Medical
University of Vienna, Vienna, Austria; 2Department
of Ophthalmology, Medical University of Vienna,
Vienna, Austria; 3Canon Inc., Tokyo, Japan *CR
239
Tuesday Posters
11:00 am – 12:45 pm
3411 — C0104 White dots as a novel marker
of diabetic retinopathy severity in ultrawide
field imaging. Yoko Dodo, T. Murakami, N. Unoki,
K. Ogino, A. Uji, S. Yoshitake, N. Yoshimura.
Opthalmology, Kyoto University Graduate School
of Medicine, Kyoto, Japan
3416 — C0109 Study of choroidal thickness
in highly myopic eyes with and without
dome shaped macula. Pauline Heitz1, 2, G.
Soudier1, V. Gualino3, 4, C. Speeg-Schatz1, A.
Gaudric3, R. Tadayoni3, D. Gaucher1, 2. 1NHC,
Ophthalmology University Hospital, Strasbourg,
France; 2Laboratoire de bactériologie fédération
de médecine translationnelle, University of
Strasbourg, Strasbourg, France; 3Ophthalmology,
Assistance Publique Hôpitaux de Paris
Université de Paris 7. Hôpital Lariboisière, Paris,
France; 4Ophthalmology, Hôpital Purpan, Toulouse,
France
3422 — C0115 Parallelism for Quantitative
Image Analysis of Photoreceptor-Retinal
Pigment Epithelium Complex Alteration
in Diabetic Macular Edema. Akihito Uji, T.
Murakami, N. Unoki, K. Ogino, S. Yoshitake, Y.
Dodo, N. Yoshimura. Ophthalmology, Kyoto Univ
Graduate Sch of Med, Kyoto City, Japan *CR
3430 — C0123 Central macular thickness of
diabetic eyes with and without exudates within
one disc diameter of the foveola. Glen Y. Ozawa1,
K. Baskaran2, T. V. Litvin1, A. E. Elsner2, 3, J.
Cuadros1, C. A. Clark2, S. Brahm2, S. B. Young2, C.
M. Robinson2, M. S. Muller3. 1UC Berkeley School
of Optometry, Berkeley, CA; 2Indiana University
School of Optometry, Bloomington, IN; 3AEON
Imaging, LLC, Bloomington, IN *CR
3431 — C0124 Prevalence of Subretinal
Drusenoid Deposits in non- Age related Macular
Degeneration retinal disease. Sharad Malavade1, 2,
B. Madow2. 1Global Health, University of South
Florida, Tampa, FL; 2Ophthalmology, USF Eye
Institute, Tampa, FL
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Retinal Cell Biology / Retina
346 AMD: Mechanism and Protection
Tuesday Posters
11:00 am – 12:45 pm
Moderator: Bela Anand-Apte
3432 — C0280 Characterization of the
Stoichiometry of Human Complement C5
Binding to LFG316. Ana Carrion, B. EtemadGilbertson, J. Zhou, A. Soni, M. Roguska. Novartis
Institutes for BioMedical Research, Cambridge,
MA *CR
3433 — C0281 Generation and
Characterization of LFG316, A Fully-Human
Anti-C5 Antibody for the Treatment of AgeRelated Macular Degeneration. Michael
Roguska1, I. Splawski1, B. DiefenbachStreiber3, E. Dolan1, B. Etemad-Gilbertson1, J.
Rondeau2, M. Keating1. 1Novartis Institutes for
BioMedical Research, Cambridge, MA; 2Novartis
Institutes for BioMedical Research, Basel,
Switzerland; 3MorphoSys AG, Martinsried,
Germany *CR
3434 — C0282 Smoke-exposure causes
endoplasmic reticulum stress and lipid
accumulation in retinal pigment epithelium
through oxidative stress and complement
activation.Baerbel Rohrer1, 2, C. Atkinson3, K.
Kunchithapautham1. 1Ophthalmology, Med Univ of
South Carolina, Charleston, SC; 2Research Service,
Ralph H. Johnson VA Medical Center, Charleston,
SC; 3Microbiology and Immunology, Med Univ of
South Carolina, Charleston, SC *CR
3435 — C0283 The Role of Nrf-2 in Alternative
Pathway (AP) Complement and Hydroquinone
(HQ)-mediated Heme Oxygenase-1 (HO1) Expression in Human RPE (hRPE)
Cells. Michelle Bao1, Z. Ma1, P. Yang1, P. Baciu2,
G. J. Jaffe1. 1Ophthalmology, Duke University Eye
Center, Durham, NC; 2Biology, Allergan Inc, Irvine,
CA *CR
3436 — C0284 Upregulation of complement
components and chemokines by interferon
gamma (IFN-γ) stimulation of retinal pigment
epithelium (RPE) in vitro. Sijia Cao, A. Wang, J.
Z. Cui, J. A. Matsubara. Ophthal & Visual Sciences,
University of British Columbia, Vancouver, BC,
Canada
3437 — C0285 Proteomics Analysis of
Protein Expression in Human RPE Cells
Exposed to Oxidant and Complement Attack
through Alternative Pathway. Ping Yang1, N.
P. Skiba1, M. Bao1, A. Long1, P. Baciu2, G. J.
Jaffe1. 1Ophthalmology, Duke University Eye
Center, Durham, NC; 2Biology, Allergan, Inc,
Irvine, CA *CR
3438 — C0286 Peroxisome proliferatoractivated receptor (PPAR) β/δ expression and
activation in retinal pigment epithelial and
choroidal endothelial cells: implication in agerelated macular degeneration. Mayur Choudhary,
G. Malek. Opthalmology, Duke Eye Center,
Durham, NC
3439 — C0287 Different Structures of Aβ1-40
Assemblies Induce Distinctive Primary RPE
Cell Responses in vitro. Jiangyuan Gao, J. Z. Cui,
A. Wang, J. A. Matsubara. Ophthalmology and
Visual Sciences, University of British Columbia,
Vancouver, BC, Canada
3440 — C0288 Exogenous regulation of the
HIF pathway in RPE cells. Helder Andre, M.
Ekstrom, A. Takei, Y. Ma, A. P. Kvanta. Clinical
Neurosciences, St Erik Eye Hospital, Stockholm,
Sweden
3441 — C0289 Effect of Dexamethasone
on Polarized H9RPE Cells. Danhong
Zhu1, J. Hsiung1, D. R. Hinton1, 2. 1Pthology,
CA;2Ophthalmology, University of Southern
3442 — C0290 Permeability of ranibizumab
and bevacizumab through the polarized RPE
cells in vitro. Hiroto Terasaki, N. Yoshihara, M.
Shirasawa, H. Otsuka, S. Sonoda, T. Sakamoto.
Ophthalmology, Kagoshima University, Kagoshima,
Japan *CR
3443 — C0291 Dissecting molecular pathways
of mTORC1 signaling in the retinal pigment
epithelium. Bo Yu, P. Xu, Z. Zhao, B. Long, J. Cai,
Y. Chen. Ophthalmology, UTMB, Galveston, TX
3445 — C0293 Humanin protects RPE
cells from oxidative stress induced cell death.
Parameswaran G. Sreekumar1, K. Ishikawa1, 4, C.
Spee2, H. Mehta3, K. Yen3, P. Cohen3, R. Kannan1,
D. R. Hinton2, 4. 1Ophthalmology, Doheny Eye
Institute, Los Angeles, CA; 2Ophthalmology,
CA; 3USC Davis School of Gerontology, Los
Angeles, CA; 4Pathology, University of Southern
3446 — C0294 Mitochondrial elongation in the
retinal epithelium of aging monkeys: evidence
of metabolic stress. Peter Gouras1, L. Ivert2,
M. Neuringer3, T. Nagasaki1.1Ophthalmology,
Columbia University, New York, NY; 2St Erik’s
Hospital, Karolinska Institute, Stockholm,
Sweden; 3Neuroscience, Oregon National Primate
Research Center, Beaverton, OR
3447 — C0295 The role of IL-6 and TNFalfa in generating the vicious inflammatory
cycle between macrophages and retinal
pigment epithelium in age-related macular
degeneration. Jun Yamada1, 2, K. Kimura2, A.
Mukai2, J. Hamuro2, S. Kinoshita2. 1Ophthalmology,
Meiji University of Integrative Medicine, Kyoto,
Japan; 2Ophthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan
3448 — C0296 Age-dependent changes in
clearance of phagocytosed photoreceptor outer
segments in the Retinal Pigment Epithelium. Pei
Xu, Z. Zhao, B. Yu, B. Long, J. Cai, Y. Chen.
Ophthalmology, UTMB, Galveston, TX
3449 — C0297 Inhibition of peroxisome
proliferator-activated receptor β/δ (PPARβ/δ)
reduces choroidal angiogenesis. Sara R. Savage,
L. L. Davia, J. S. Penn. Pharmacology, Vanderbilt
Univ Medical Center, Nashville, TN
3450 — C0298 Comparative analysis of retinal
phenotype in Cfh-/-, Cfb-/- and Cfh-/-Cfb-/- double
knock-out mice. Jennifer A. Williams1, J.
Greenwood1, J. Latcham2, P. S. Adamson2, S. E.
Moss1. 1Cell Biology, Institute of Ophthalmology,
UCL, London, United Kingdom; 2Ophthiris
Discovery Performance Unit and Department of
Laboratory Animal Science, GlaxoSmithKline,
Stevenage, United Kingdom *CR
3451 — C0299 Generation of iPSC derived
vascular endothelial cells for the treatment of
AMD. Allison E. Songstad1, C. M. Cranston1, M.
J. Flamme-Wiese1, E. M. Stone1, 2, R. Mullins1, B.
A. Tucker1. 1Stephen A. Wynn Institute for Vision
Research, Carver College of Medicine, Department
of Iowa, Iowa City, IA;2Howard Hughes Medical
Institute, University of Iowa, Iowa City, IA
3444 — C0292 Complement component C5a
primes the NLRP3 inflammasome in retinal
pigment epithelial cells. Carolina Brandstetter, F.
G. Holz, T. U. Krohne. Ophthalmology, University
of Bonn, Bonn, Germany
240
3452 — C0300 Induction of vascular
endothelial growth factor and vascular
endothelial growth factor receptor after
repeated bevicizumab treatment in human
umbilical vein endothelial cells. Ji Eun E.
Lee1, 2, H. Jeon1, J. Kim1, J. Jung1, 3, D. Shin4,
M. Shin1. 1Ophthalmology, Pusan National
Univesity, Busan, Republic of Korea; 2Medical
Research Institute, Pusan National University
Hospital, Busan, Republic of Korea; 3Convergent
Biomedical Research Institute, Yangsan Pusan
National University Hospital, Busan, Republic
of Korea; 4Pathology, Pusan National Univesity,
Busan, Republic of Korea
3453 — C0301 Regulation of Exosomes by
Autophagy in Retinal Pigment Epithelium:
an Implication of the Formation of
Drusen. Jeehyun Yoon1, A. Choi1, H. J. Lim2,
H. Chung1. 1Ophthalmology, Konkuk University
School of Medicine, Seoul, Republic of
Korea; 2Biomedical Science & Technology, Konkuk
University, Seoul, Republic of Korea
3454 — C0302 Aberrant Cell and Basement
Membrane Architecture Contribute to
Sidestream Smoke-induced Choroidal
Endothelial Dysfunction. Xiao Yang, H. Scott, S.
Ardekani, K. Ghosh. Bioengineering, University of
California, Riverside, Riverside, CA
3456 — C0304 Increased expression of
mitochondrial glutaredoxin 2 (Grx2) protects
human retinal pigment epithelial cells from
oxidative stress-induced cell death. Hongli
Wu1, 2, X. Liu1, J. Jann3. 1Pharmaceutical Sciences,
University of North Texas Health and Science
Center, Fort Worth, TX; 2Institute for Cancer
Research, University of North Texas Health and
Science Center, Fort Worth, TX; 3University of
Georgia, Athens, GA
3457 — C0305 Histone Deacetylase Expression
and Inhibition in Age Related Macular
Degeneration. Mark E. Kleinman1, A. Berner1, K.
Mohan1, D. Lou1, J. Brown1, J. West1, R. Kono1, I.
Sugino3, M. Zarbin3, J. Ambati1, 2. 1Ophthalmology
& Visual Sci, Univ of Kentucky, Lexington,
KY; 2Physiology, University of Kentucky,
Lexington, KY; 3Institute of Ophthalmology &
Visual Science, New Jersey Medical School,
Newark, NJ
3458 — C0306 Liver X Receptor signaling
pathways and age-related macular degeneration.
Goldis Malek1, M. Choudhary2, E. Meade2, E.
Nelson3, D. McDonnell3.1Ophthalmology and
Pathology, Duke University, Durham, NC;
2
Ophthalmology, Duke University, Durham,
NC; 3Pharmacology and Cancer Biology, Duke
3460 — C0308 Expression of ADAMs (A
Disintegrin and Metalloproteinase) 10 and 17 in
Human Eyes and in Experimental Models of Age
Related Macular Degeneration (AMD). Chris
Or1, J. Wang2, L. Kojic1, W. Jia3, M. S. Cynader1,
J. Z. Cui1, J. A. Matsubara1. 1Department of
Ophthalmology & Visual Sciences, University
of British Columbia, Vancouver, BC, Canada;
2
Department of Anatomy and Embryology,
Peking University Health Science Center, Beijing,
China; 3Department of Surgery, University of
British Columbia, Vancouver, BC, Canada
3461 — C0309 XIAP’s Association with NLRP3
Inflammasome in Human Donor Eyes. Jing Z.
Cui, J. Gao, E. To, J. A. Matsubara. Ophthalmology
& Visual Sciences, University of British Columbia,
Vancouver, BC, Canada
3462 — C0310 Molecular And Functional
Changes In The Retina Of Mice Deficient In
Complement Factor H And Apolipoprotein
E. Maria Hernandez1, L. Garcia-Garcia1, S.
Recalde1, P. Fernandez1, M. Moreno-Orduña1, L.
Fernandez Sanchez2, L. Ramirez3, P. de la Villa3,
N. Cuenca2, A. Garcia-Layana1, 4. 1University of
Navarra, Pamplona, Spain; 2University of Alicante,
33001, Spain; 3University of Alcala, 28871,
Spain; 4Opthalmology, Clinica Universidad de
Navarra, Pamplona, Spain
3463 — C0311 RNA sequencing reveals altered
gene expression signatures in complement
challenged primate choroidal endothelial cells. S
Scott Whitmore1, 2, S. Zeng1, 2, M. J. Riker1, 2, E.
M. Stone1, 2, B. A. Tucker1, 2, T. E. Scheetz1, 2,
R. F. Mullins1, 2. 1Stephen A. Wynn Institute for
Vision Research, The University of Iowa, Iowa
City, IA; 2Ophthalmology & Visual Sciences, The
University of Iowa, Iowa City, IA
3464 — C0312 The retina and the ascending
visual pathway share common age-related
protein changes. Michael R. Boehm1, 2, C. Nolte2,
A. Heiligenhaus1, 2, S. Thanos1. 1Institute for
Experimental Ophthalmology, School of Med,
WWU Muenster, Muenster, Germany; 2Department
of Ophthalmology, St. Franziskus Hospital,
Münster, Germany
3465 — C0313 Construction of Recombinant
AAV-based Vectors bearing miR-183 Cluster
Genes. Maliheh Davari1, H. Ahmadieh2, Z. Soheili1,
S. Samiei1, E. Ranaei1, M. Rezaei Kanavi2. 1basic
biotechnology, national institute of genetic
engineering and biotechnology, Tehran, Islamic
Republic of Iran; 2Ophthalmic Research Center,
Shahid Beheshti University of Medical Sciences,
Tehran, Islamic Republic of Iran
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Biochemistry/Molecular Biology / Clinical/
Epidemiologic Research / Retina
347 Retinoids, Carotenoids and
Macular Pigment
Moderators: Stephanie A. Hagstrom and
Jian-Xing Ma
3466 — D0066 How to obtain a rhodopsin
spectrum from a turbid suspension - beating
the light scatter problem. Federico GonzalezFernandez1, R. DeSa2. 1Med Res Svc/Veterans
Affairs, SUNY at Buffalo, Buffalo, NY; 2Olis Inc.,
Bogart, GA *CR
3467 — D0067 Retinoid Uptake, Processing
and Secretion in Human iPS-RPE Support the
Visual Cycle. Alberto Muniz1, W. Greene1, M.
Plamper1, J. Choi1, A. J. Johnson1, A. T. Tsin2, H.
H. Wang1. 1Ocular Trauma, United States Army
Institute of Surgical Research, Fort Sam Houston,
TX; 2Department of Biology, The University of
Texas at San Antonio, San Antonio, TX
3468 — D0068 Early Morphological Changes
in IRBP Knockout Mice. Shannon Getz, M.
A. Chrenek, N. Williams, J. H. Boatright, J. M.
Nickerson. Ophthalmology, Emory University,
Atlanta, GA
3469 — D0069 Evaluation of mutant retinol
cycle enzymes. Markus N. Preising, A. Janise,
H. Ina, W. Julia, B. Lorenz. Department of
Ophthalmology, Justis-Liebig University, Giessen,
Germany
3470 — D0070 The Investigation of Human
Retinal Lipofuscin Fluorophores in Association
with Age Related Macular Degeneration. Jennifer
Tournear1, J. P. Dillon1, E. R. Gaillard1, 2. 1Chemistry
and Biochemistry, Northern Illinois University,
Dekalb, IL; 2Biology, Northern Illinois University,
Dekalb, IL
3471 — D0071 P25L knock-in of
mouse Rpe65 shows little change in visual
function under normal low light conditions but
confers protection against acute high intensity
light damage. T M. Redmond1, T. Duncan1, Y.
Li2, H. Qian2, L. Dong3, Y. Li1. 1Lab. of Retinal
Cell & Molecular Biology, National Eye Inst/NIH,
Bethesda, MD; 2Visual Function Core, National
Eye Institute, Bethesda, MD; 3Genetic Engineering
Core, National Eye Institute, Bethesda, MD
3472 — D0072 Interphotoreceptor retinoidbinding protein promotes delivery of all-trans
retinol into rat Müller Cells in culture. Brandi
S. Betts-Obregon1, F. Gonzalez-Fernandez2, A.
S. Mendiola1, A. T. Tsin1. 1Biology, University of
Texas at San Antonio, San Antonio, TX; 2Med Res
Svc/Veterans Affairs, SUNY at Buffalo,
Buffalo, NY
241
Tuesday Posters
11:00 am – 12:45 pm
3455 — C0303 Non-vascular effects of VEGF
in a model of age-related macular degeneration.
Michael R. Kozlowski. Optometry, Midwestern
Univ/Arizona Coll of Optom, Glendale, AZ
3459 — C0307 AMD-compatible lysosomal
changes in Rab38-deficient mouse model.
Tanya Tolmachova1, D. A. Feleciano1, S.
Wavre-Shapton1, 2, M. J. Evans1, C. Futter2,
M. C. Seabra1. 1Molecular Medicine, NHLI,
Imperial College London, London, United
Kingdom; 2Division of Cell Biology, Institute
of Ophthalmology, University College London,
3473 — D0073 Hyper Phototransduction
of Cone and Rod Photoreceptors in Cntf-/Mice is Underpinned by Upregulated Opsins
and RPE65. Minghao Jin1, S. Li1, K. Sato1, M.
Sendtner2. 1Ophthalmology & Neuroscience, LSU
Health Sciences Center, New Orleans, LA; 2Institute
for Clinical Neurobiology, University of Würzburg,
Würzburg, Germany
3474 — D0074 Inhibition of RPE65 retinol
isomerase activity by inhibitors of lipid
metabolism. Abdulkerim EROGLU, S. Gentleman,
E. Poliakov, T. M. Redmond. Laboratory of Retinal
Cell and Molecular Biology, National Eye Institute,
Bethesda, MD
Tuesday Posters
11:00 am – 12:45 pm
3475 — D0075 PSMD13 Promotes
Degradation of Disease-Causing RPE65s via
the Ubiquitin-Proteasome Pathway. Songhua
Li1, T. Izumi2, J. Hu3, S. G. Jacobson4, D. Bok3,
M. Jin1. 1Ophthalmology and Neuroscience,
LSU Health Sciences Center, New Orleans,
LA; 2Toxicology, University of Kentucky,
Lexington, KY; 3Jules Stein Eye Institute, UCLA,
Los Angeles, CA; 4Scheie Eye Institute, University
of Pennsylvania, Philadelphia, PA
3476 — D0076 Identification of Key Residues
Enhancing Isomerohydrolase Activity of Human
RPE65 for More Efficient Gene Therapy. Yusuke
Takahashi1, 3, G. P. Moiseyev2, 3, J. Ma2, 3. 1Medicine,
University of Oklahoma Health Sciences Center,
Oklahoma City, OK; 2Physiology, University of
Oklahoma Health Sciences Center, Oklahoma City,
OK; 3Harold Hamm Diabetes Center, Oklahoma
City, OK
3477 — D0077 Identification and in vitro
Characterization of Novel Non-retinoid RPE65
Inhibitors. Gennadiy P. Moiseyev1, J. Ma1, K.
Petrukhin2. 1Physiology, Univ of Oklahoma Hlth
Sci Ctr, Oklahoma City, OK; 2Ophthalmology,
Columbia University, New York, NY
3478 — D0078 Over-expression of
RBP4 Causes Progressive Retinal
Degeneration in Mice. Krysten M. Farjo1,
L. Otalora1, T. Hollingsworth1, R. Farjo2, A.
Quiambao2.1Physiology, University of Oklahoma
Health Sciences Center, Oklahoma City,
OK; 2EyeCRO LLC, Oklahoma City, OK *CR
3479 — D0079 Role of plasma HDL remodeling
and intestinal ABCA1 activity in the uptake of
dietary lutein and zeaxanthin. Eric J. Niesor,
E. Chaput. F. Hoffmann-La Roche, Basel,
Switzerland *CR
3480 — D0080 Three Characteristics of the
Central Macula: Light, AMD, and Macular
Carotenoids. Richard A. Bone1, J. C. Gibert2,
A. Mukherjee1. 1Physics, Florida International
University, Miami, FL; 2Natural Science, Health &
Wellness, Miami-Dade College, Miami, FL
3481 — D0081 A Virtual Model for
Development of Macular Pigment in the
Macaque Retina. John T. Landrum1, V. Mendez1, Y.
Cao1, M. Neuringer2. 1Chemistry and Biochemistry,
Florida International University, Miami, FL;
2
Division of Neuroscience, ONPRC, Oregon Health
& Science University, Portland, OR *CR
3482 — D0082 Long-Term Zeaxanthin
Supplementation to the Mouse Retina. Binxing
Li, P. P. Vachali, A. Gorusupudi, Z. Shen, K.
Nelson, B. Besch, P. S. Bernstein. Ophthalmology
and Visual Sciences, Univ of UT Sch Med/Moran
Eye Ctr, Salt Lake City, UT
3483 — D0083 Response of visual function
to multiple xanthophyll supplementation
in patients with retinal diseases. Roxanne
R. Crosby-Nwaobi1, K. Bibi1, T. Peto1, 2, P. G.
Hykin1, S. Sivaprasad1. 1NIHR Clinical Research
Facility, Moorfields Eye Hospital, London, United
Kingdom; 2Reading Centre, Moorfields Eye
Hospital, London, United Kingdom *CR, f
3484 — D0084 Major American dietary
patterns are related to risk of age-related
macular degeneration. Chung-Jung Chiu1, 2,
M. Chang1, F. Zhang3, T. Li4, G. Gensler5, M.
Schleicher1, A. Taylor1, 2. 1USDA Human Nutrition
Research Center on Aging, Tufts University,
Boston, MA; 2Department of Ophthalmology,
School of Medicine, Tufts University, Boston,
MA; 3Friedman School of Nutrition Science and
Policy, Tufts University, Boston, MA; 4Channing
Division of Network Medicine, Brigham and
Women’s Hospital, Harvard Medical School,
Boston, MA; 5AREDS Coordinating Center, The
EMMES Corporation, Rockville, MD
3485 — D0085 The effect of short term
nutritional supplementation on macular pigment
optical density. Adam McGuinness, F. Eperjesi, H.
Bartlett. School of Optometry, Aston University,
Birmingham, United Kingdom f
3489 — D0089 The relationship between
macular pigment and visual function among
glaucoma subjects: A baseline evaluation of the
Macular Pigment and Glaucoma Trial.James
Loughman1, W. Siah2, C. J. O’Brien2. 1Optometry,
Dublin Institute of Technology, Dublin,
Ireland; 2Ophthalmology Department, Institute of
Ophthalmology, Dublin, Ireland f
3490 — D0090 The relationship between
macular pigment and glaucoma-related
structural parameters: A baseline evaluation
of the Macular Pigment and Glaucoma
Trial. We Fong Siah1, J. Loughman2, C. J.
O’Brien1. 1Ophthalmology, Mater Misericordiae
University Hospital, Dublin, Ireland; 2Optometry,
Dublin Institute Technology, Dublin, Ireland f
3491 — D0091 Associations between Dietary
Intake of Lutein and Diabetic Retinopathy in the
Atherosclerosis Risk in Communities (ARIC)
Study. Michelle Sahli1, R. Klein3, J. A. Mares3, K.
J. Meyers3, H. M. Ochs-Balcom1, W. E. Brady2, 1,
B. E. Klein3, R. P. Donahue1, A. E. Millen1. 1Social
and Preventive Medicine, State University of
New York at Buffalo, Buffalo, NY; 2Department
of Biostatistics and Bioinformatics, Roswell Park
Cancer Institute, Buffalo, NY; 3Ophthalmology and
Visual Sciences, University of Wisconsin,
Madison, WI
3492 — D0092 Association of Macular
Pigment Optical Density (MPOD) and
age in ocular healthy adults of different
ethnicities -A preliminary report. Pinakin G.
Davey1, 2, F. Carusone2, S. Alvarez1, P. Vyas1,
J. Greenan1, T. Thamsopit1, S. Zaczyk1, R.
Shah1, C. Lievens2. 1College of Optometry,
Western University of Health Sciences, Pomona,
CA; 2Southern College of Optometry, Memphis, TN
3486 — D0086 Optimization of Retinal
Uptake of Lutein and Zeaxanthin in Transgenic
Mice. Preejith P. Vachali, B. Li, A. Gorusupudi, Z.
Shen, B. Besch, K. Nelson, P. S. Bernstein. Moran
Eye Center, University of Utah, Salt Lake City, UT
Tuesday, May 06, 2014 11:00 AM-12:45 PM
3487 — D0087 Zebrafish mutants as
models for studying receptors involved in
the intestinal uptake of dietary vitamin A for
vision. Glenn P. Lobo1, B. D. Perkins1, 2, J. Heath3,
J. von Lintig4, S. A. Hagstrom1, 2. 1Ophthalmic
Research, Cole Eye Institute, Cleveland Clinic
Foundation, Cleveland, OH; 2Ophthalmology,
Lerner Research Institute, Cleveland Clinic
Foundation, Cleveland, OH; 3Chemical Biology,
Walter and Eliza Hall Institute, Melbourne, VIC,
Australia; 4Pharmacology, Case Western Reserve
University, Cleveland, OH
Moderator: Haohua Qian
Visual Neuroscience
348 ERG and VEP: human studies
3493 — D0093 Adaptation recovery of
the photopic multi-focal ERG in early and
intermediate age-related macular degeneration.
Athanasios Panorgias1, M. Tillman1, E. E. Sutter2, J.
S. Werner1, 3. 1Ophthalmology and Vision Science,
University of California Davis, Sacramento,
CA; 2Electro-Diagnostic Imaging, Inc., Redwood
City, CA; 3Neurobiology, Physiology and Behavior,
University of California Davis, Davis, CA *CR
3488 — D0088 Bioavailability of α- and
β-Cryptoxanthin in Serum, Liver, and Ocular
Tissues of Japanese Quail. Paul S. Bernstein1, B.
Li1, P. P. Vachali1, A. Gorusupudi1, F. Khachik2.
1
Ophthal and Visual Sciences, University of Utah,
Salt Lake City, UT; 2Chemistry and Biochemistry,
University of Maryland, College Park, MD
242
3494 — D0094 Sleep Quality in AgeRelated Macular Degeneration (AMD).
Robert M. Purbrick1, 2, J. C. Wong2, R. Safa2,
I. Alexander2, R. Morjaria1, 2, K. Wulff2, R. G.
Foster2, S. M. Downes1, 2. 1Oxford Eye Hospital,
Oxford University Hospitals, Oxford, United
Kingdom; 2Nuffield Laboratory of Ophthalmology,
Nuffield Department of Clinical Neurosciences,
Oxford University, Oxford, United Kingdom
3495 — D0095 To investigate the impact of
diabetic retinopathy of varying severity on
sleep. Rupal Morjaria1, 2, I. Alexander2, O. Kousha1,
R. Safa2, R. M. Purbrick1, 2, V. Chong1, 2, K. Wulff2,
R. G. Foster2, S. M. Downes1, 2. 1Ophthalmology,
Oxford Hospitals NHS Trust, Oxford, United
Kingdom; 2Nuffield Department of Ophthalmology,
Nuffield Department of Clinical Neurosciences,
Oxford, United Kingdom
3496 — D0096 Visual consequences of mild
traumatic brain injury in veterans. Chrystyna
Rakoczy1, R. T. Tzekov2, 3. 1James A Haley Veterans’
Hospital, Tampa, FL; 2The Roskamp Institute,
Sarasota, FL; 3University of South Florida,
Tampa, FL
3498 — D0098 Effect of Binasal Occlusion
and Base-In Prisms on the Visual-Evoked
Potential (VEP) in the Visually-Normal and Mild
Traumatic Brain Injury Populations. Naveen
K. Yadav, K. J. Ciuffreda. Biological and Vision
Sciences, SUNY, College of Optometry,
New York, NY
3509 — D0109 Rod- and cone-isolated
flicker electroretinograms and their response
summation characteristics. J Jason McAnany,
J. C. Park, D. Cao. Ophthalmology and Visual
Sciences, University of Illinois at Chicago,
Chicago, IL
3503 — D0103 Evaluation of the Unaffected
Fellow Eye of Unilateral Exfoliation Syndrome
and Exfoliation Glaucoma Eyes using Short
Duration Transient Visual Evoked Potentials
(SD-tVEP). Lam Lu1, P. H. Derr2, J. V. Jasien1, A.
O. Gonzalez Garcia2, C. Tello1, J. M. Liebmann1, 3,
R. Ritch1, 4. 1Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York,
NY; 2Diopsys Inc., Pine Brook, NY; 3NYU School
of Medicine, New York, NY; 4New York Medical
College, Valhalla, NY *CR
3510 — D0110 Contribution of oscillatory
potentials to the ON- and OFF- photopic
electroretinogram (ERG) in human.
Jonathan Gotzmann1, I. Dimopoulos2, Y.
Sauve2, 1.1Physiology, University of Alberta,
Edmonton, AB, Canada; 2Ophthamology, University
of Alberta, Edmonton, AB, Canada
3504 — D0104 Macular function measured
with mfERG in prematurely-born children at
school-age. Hanna M. Akerblom1, G. Holmstrom1,
S. Andreasson2.1Neurosience/Ophthalmolgy,
Uppsala University, Uppsala, Sweden; 2Lund
University, Lund, Sweden
3505 — D0105 Retinal Remodeling in
Retinopathy of Prematurity. James D.
Akula1, 2, A. Mocofanescu1, R. D. Ferguson3, 1,
M. Mujat3, J. Tavormina1, T. L. Favazza1, E. A.
Swanson1, A. Moskowitz1, 2, R. M. Hansen1, 2, A.
Fulton1, 2. 1Ophthalmology, Boston Children’s
Hospital, Boston, MA; 2Ophthalmology, Harvard
Medical School, Boston, MA; 3Biomedical Imaging
Group, Physical Sciences, Inc., Andover, MA *CR
3506 — D0106 Infantile nystagmus syndrome
in childhood: Isolation of the visual cortical
signal. John P. Kelly1, 2, F. Darvis2, J. O. Phillips1, 2,
A. H. Weiss1, 2. 1Ophthalmology OA.6.293, Seattle
Children, Seattle, WA; 2University of Washington,
Seattle, WA
3499 — D0099 Oculomotor Vision
Rehabilitation in Mild Traumatic Brain Injury:
Effect on the Visual Evoked Potential (VEP) and
Visual Attentional (VAT) Responsivity. Kenneth
J. Ciuffreda, N. K. Yadav. Biological and Vision
Sciences, SUNY College of Optometry,
New York, NY
3507 — D0107 Visual evoked cortical potential
kernels elicited by m-sequences: a principal
component analysis. Carolina S. Araujo1, G. S.
Souza1, 2, L. L. Silveira1, 2. 1Instituto de Ciencias
Biologicas, Universidade Federal do Para, Belem,
Brazil; 2Nucleo de Medicina Tropical, Universidade
Federal do Para, Belem, Brazil
3500 — D0100 A Retrospective Analysis of
Photosensitivity in Mild Traumatic Brain-Injury
(mTBI). James Q. Truong, K. J. Ciuffreda, E. Han,
I. Suchoff. Biological and Vision Sciences, SUNY
College of Optometry, New York, NY
3508 — D0108 The influence of
stimulus size on L- and M-cone driven
electroretinograms. Mellina M. Jacob1, B.
D. Gomes1, G. S. Souza1, 2, M. da Silva1, D. J.
Mckeefry3, N. R. Parry4, L. L. Silveira1, 2, J.
Kremers5. 1Instituto de Ciências Biológicas,
Universidade Federal do Pará, Belém,
Brazil; 2Núcleo de Medicina Tropical, Universidade
Federal do Pará, Belém, Brazil; 3Bradford School
of Optometry and Vision Science, University of
Bradford, Bradford, United Kingdom; 4Vision
Science Centre, Manchester Royal Eye Hospital,
Manchester, United Kingdom; 5Department of
Ophthalmology, University Hospital Erlangen,
Erlangen, Germany
3501 — D0101 The Effect of Induced
Meridional Refractive Defocus on the
Amplitude and Implicit Time of Multifocal
Electroretinogram (mfERG). Saiful Azlan Rosli,
A. Chen, N. Che Alwi, M. Mohamad-Rafiuddin.
Optometry Department, Universiti Teknologi
MARA (UiTM), Puncak Alam, Malaysia
3511 — D0111 Statistical Decomposition of
the Electroretinogram into its Components. Ye
Chen1, J. Tang2, M. Sarossy2, 1. 1The Royal Victorian
Eye and Ear Hospital, East Melbourne, VIC,
Australia; 2Centre for Eye Research Australia, East
Melbourne, VIC, Australia
Tuesday, May 06, 2014 11:00 AM-12:45 PM
Visual Neuroscience
349 Retinal Development
Moderator: Rene C. Renteria
3512 — D0112 Dopamine D2 receptor regulates
the functional development of retina. Ning
Tian1, H. Xu2, P. Wang1. 1Ophthalmology & Visual
Science, University of Utah, Salt Lake City,
UT; 2Neurobiology, Yale University, New Haven,
CT
3513 — D0113 Influence of ON and OFF
Pathways on Visual Function Development. Moe
H. Aung1, H. Park1, C. S. Sidhu1, P. M. Iuvone1, 2, M.
T. Pardue1, 3.1Neuroscience/Ophthalmology, Emory
University, Atlanta, GA; 2Pharmacology, Emory
University, Atlanta, GA; 3Rehab R&D Center of
Excellence, Atlanta VA Medical Center, Atlanta, GA
3514 — D0114 Double olfm1a and olfm1b
knockout in zebrafish causes moderate
abnormality in retinal development and
function. Naoki Nakaya1, T. Yokogawa2, H. Qian3,
F. Ono4, H. A. Burgess2, S. I. Tomarev1. 1Section
of Retinal Ganglion Cell Biology, National Eye
Institute/NIH, Bethesda, MD; 2Section of Vertebrate
Organogenesis, National Institute of Child
Health and Human Development/NIH, Bethesda,
MD; 3Visual Function Core, National Eye Institute/
NIH, Bethesda, MD; 4Section of Model Synaptic
Systems, National Institute on Alcohol Abuse and
Alcoholism/NIH, Rockville, MD
3515 — D0115 MMP-2 and MT1-MMP as
axonal outgrowth-promoting molecules in the
neuroretina. Lieve K. Moons1, T. Buyens1, K.
Lemmens1, M. Salinas-Navarro1, N. Behrendt2, I.
Van Hove1, D. Gaublomme1, L. De Groef1. 1Biology
Department, Zoological Inst, University of
Leuven (KU Leuven), Leuven, Belgium; 2The
Finsen Laboratory, University of Copenhagen,
Copenhagen, Denmark
243
Tuesday Posters
11:00 am – 12:45 pm
3497 — D0097 Effect of Luminance on the
Visual Evoked Potential (VEP) in VisuallyNormal and Mild Traumatic Brain Injury
(mTBI) Populations. Vanessa Fimreite, N. K.
Yadav, K. J. Ciuffreda. Biological and Vision
Sciences, SUNY College of Optometry,
New York, NY
3502 — D0102 Pattern electroretinogram in
pre-perimetric and hemifield loss glaucoma eyes
and its correlation with Fourier Domain OCT
macular thickness measurements.Andre C. Kreuz,
M. K. Oyamada, M. L. Monteiro. Ophthalmology,
University of São Paulo, São Paulo, Brazil
3516 — D0116 The Transcription Factor
Math5 Is Not Required For Specification Of A
Subset Of Retinal Ganglion Cells. Justin BrodieKommit1, T. M. Schmidt1, S. Hattar1, 2.1Biology,
Johns Hopkins University, Baltimore,
MD; 2Neuroscience, Johns Hopkins University,
Baltimore, MD
3517 — D0117 The Role of NMDA Receptor
Activity in Retinal Ganglion Cell Dendrite
Development. Eerik Elias1, 2, P. Wang2,
N. Tian2, 1. 1Interdepartmental Program in
Neuroscience, University of Utah, Salt Lake City,
UT; 2Department of Ophthalmology and Visual
Science, University of Utah School of Medicine,
Salt Lake City, UT
3518 — D0118 A role for HCN channels in
coordinating activity during glutamatergic
retinal waves. Marla Feller1, 2, A. Firl2, 1. 1Molecular
and Cell Biology, University of California,
Berkeley, Berkeley, CA; 2Vision Science Graduate
Group, University of California, Berkeley, Berkeley,
CA
Tuesday Posters
11:00 am – 12:45 pm
3519 — D0119 RGC receptive field diameters
are smaller in dark reared mice. Nikolay Akimov,
R. C. Renteria. Physiology, Univ of Texas Health
Science Center at SA, San Antonio, TX
3520 — D0120 Cone Photoreceptor Afferents
and Dendritic Development of S-cone Bipolar
Cells in the Mouse Retina. Li Jia, W. Li. National
Eye Institute, Bethesda, MD
S 320EF
Tuesday, May 06, 2014 1:00 PM-2:30 PM
350 MIT Poster Award Session/Judging
244
Tuesday – Workshops/SIGs
S 210DE
S 230EF
S 230GH
Tuesday, May 06, 2014 1:00 PM-2:30 PM
Tuesday, May 06, 2014 1:00 PM-2:30 PM
Tuesday, May 06, 2014 1:00 PM-2:30 PM
Low Vision Group
352 Safely Taking Risks in Public and
Patient Involvement
353 NIH-CSR Peer Review Workshop
351 Low Vision Group: Binocular
Vision Meets Low Vision
Most patients with impaired vision view binocularly
when performing activities of daily living. Yet
for many years we have relied on monocular
assessments of the preferred retinal locus (PRL)
and have given relatively little consideration to
whether binocular rivalry or suppression might
limit functionality of low vision devices (e.g.,
unilaterally-fitted prisms for hemianopia). This
symposium will bring together binocular vision
experts and low-vision researchers to discuss
recent advances in evaluation and understanding of
binocular aspects of low vision rehabilitation.
Moderators: Eli Peli and Ronald A. Schuchard
— 1:00 Introduction & Announcements
— 1:15 Binocularity and Ocular Motor
Function in AMD. Esther G. Gonzalez. Vision
Science Research Program, Toronto Western
Hospital, Toronto, ON, Canada
— 1:45 Diplopia and Confusion: Partners in
Discomfort, Mostly Together, but Sometimes
Separate. Eli Peli. Ophthalmology, Schepens ERI,
Mass Eye & Ear, Boston, MA
— 2:00 Does binocular suppression limit
the functionality of unilateral low vision
devices? Nicole C. Ross. 1Ophthalmology,
Johns Hopkins Wilmer Eye Institute, Baltimore,
MD;2Ophthalmology, Schepens Eye Research
Institute, Massachusetts Eye and Ear, Boston, MA
Moderators: Linda K. McLoon and
Julie T. Daniels
— 1:00 Cornea Connect: Bringing Together
Scientists and Patients. Victoria E. Tovell.
Kingdom
— 1:00 Broad Impacts: Introducing science
policy issues to biomedical scientists. Tess
Kornfield. Neuroscience, University of Minnesota,
Minneapolis, MN
— 1:00 Talking Points: Why Fund Vision
Research. James Jorkasky. National Alliance for
Eye and Vision Research, Rockville, MD
— 1:00 Setting priorities for eye research from
the patient perspective. Dolores Conroy. Fight for
Sight, London, United Kingdom
— 1:00 Advocating for the Use of Animals
in Research. Deborah C. Otteson. Optometry,
University of Houston, Houston, TX
Sponsored by the NIH Center for Scientific Review
(CSR) this workshop is designed to inform grant
applicants and reviewers about the NIH peer
review process and also provide information about
the study sections that review visual system grant
applications. Scientific Review Officers (SROs)
from CSR will be on hand for presentation and will
be available to answer questions.
— 1:00 Overview: Peer Review
— 1:10 Panel Discussion Participant Biology of the Visual System (BVS) Study
Section. Michael Chaitin.
— 1:30 Panel Discussion Participant - Diseases
and Pathophysiology of the Visual System
(DPVS) Study Section. Nataliya V. Gordiyenko.
Center for Scientific Review, NIH, Bethesda, MD
— 1:50 Panel Discussion Participant - Small
Business: Sensory Technologies [ETTN-12]
Study Section. Paek-Gyu Lee. National Institutes
— 2:10 Panel Discussion Participant - Cell
Biology Review Group. Maqsood Wani. NIH,
Bethesda, MD
S 320CD
Tuesday, May 06, 2014 1:00 PM-2:30 PM
354 The Symbiosis of Global Eye
Research: Building Bridges between the
Developed and Developing Worlds
Why pursue global health research? In this
workshop, some of the world’s top vision
researchers will discuss the inherent benefits of
collaborating with scientists from other parts of the
world in the study of eye disorders and diseases. Of
primary interest are the interdependencies that exist
between researchers from developed and developing
countries, and how those relationships are vital in
accelerating personal research goals as well as the
field itself. Researchers from developed countries
benefit by learning about new diseases as well as the
genetic and environmental factors that contribute to
them. Investigators from developing countries gain
access to state-of-the-art facilities and sophisticated
instrumentation. And both groups benefit from the
ability to access large, diverse cohorts for potential
studies as well as the unique insights that are
brought out when people of varied backgrounds
come together. The aim of this global vision
research symposium are to bring the world leaders
of the eye diseases research to discuss how global
collaborations can be accelerated to understand the
eye diseases and prevent blindness.
245
Tuesday Workshops/SIGs
1:00 pm – 2:30 pm
— 1:30 Binocular vision and depth perception
in Individuals with central vision loss. Preeti
Verghese. Smith Kettlewell Inst, San Francisco, CA
There are many strategies that can be used to
promote support from local communities and
local governmental leaders. This workshop will
consist of mini-presentations that specifically
highlight different approaches vision researchers
have used to promote public and patient awareness
and empowerment. After the short presentations,
round table discussions of each of the main topics
will allow attendees to get practical information
on how to do this type of advocacy in their own
communities and with the political leaders in
their community. Topics to be covered include: 1)
identifying local stakeholders and co-advocates;
2) educating local vision scientists in the power
and importance of advocacy for their future
research/practice of medicine; 3) how to increase
participation in advocacy activities; 4) how to
program local advocacy events; 5) how local
advocacy can be integrated with regional and
global advocacy; 6) methods for empowerment for
individuals to participate in advocacy for vision
research. The overarching goals of the workshop
are to get each attendee to do some advocacy
activity at the local level and include: Pro-active
communication of the need for increased support
of vision research at the federal, state and local
levels Creating the means, methods and information
base for rapid responses of the membership to the
legislative and budget process Building passion
within ARVO for advocacy in favor of vision
research Outreach to the community at large
and partnering with eye research foundations in
advocacy efforts where appropriate
Moderators: Alfred Sommer and Gyan Prakash
— 1:00 Global Eye Research: Why? Alfred
Sommer. 1, Baltimore, MD; 2Wilmer Eye Institute,
Johns Hopkins, baltimore, MD
— 1:11 OpenEyes - Open source EMR software
for use in clinical care and research. Bill Aylward.
Moorfields Eye Hospital, Londonw, United
Kingdom
— 1:22 Global Collaboration and Research
Capacity Building. Gullapalli N. Rao. L V Prasad
Eye Institute, Hyderabad, India
1:00 pm – 2:30 pm
— 1:33 Global Strategies for Epidemiological
Research: Diabetic Retinopathy as a
Case Study. Tien Y. Wong. 1Singapore Eye
Research Institute, Singapore, Singapore,
Singapore;2Ophthalmology, National University of
Singapore, Singapore, Singapore *CR
— 1:00 En Face OCT Angiography of the Optic
Disc and Macula. David Huang. Oregon Health &
Science University, Portland, OR
— 1:00 Macula Microstructure and Enface
OCT. Bruno Lumbroso. Centro Oftalmologico
Meditarraneo for Retina Diseases, Roma, Italy
— 1:00 En Face OCT Imaging in AMD
and Macular Telangiectasia Type 2. Philip J.
Rosenfeld. Bascom Palmer Eye Institute, Miami, FL
— 1:00 Ultrahigh speed long wavelength swept
source OCT for structural and angiographic
imaging. James G. Fujimoto. Electrical
Engineering, Massachusetts Institute of Technology,
Boston, MA
— 1:00 OCT Angiography of the
Macula. Richard B. Rosen. Ophthalmology, NY
Eye & Infirmary, New York, NY
S 310E-H
Tuesday, May 06, 2014 1:00 PM-2:30 PM
357 Managing Patients with Diabetic
Macular Edema, Neovascular AMD, or
Retinal Vein Occlusion: How to Best
Utilize Data from Clinical Trials – SIG
Moderator: Diana V. Do
The proposed SIG will provide a forum for
interpretation of the significance of the results and
discussion as to how the results will be translated
into clinical practice. There will be no rehash of
data presented elsewhere at ARVO. The audience
will be encouraged to participate in the discussion.
— 1:44 Education for building
research. Martine Jager. 1Ophthalmology, The
Netherlands, Leiden, Netherlands; 2Ophthalmology,
Peking University Health Science Center, Bejing,
China
— 1:00 En Face OCT Patterns of
choriocapillaris and of choroidal vascular
layers and their changes in active polypoidal
choroidal vasculopathy. Gabriel J. Coscas. Hopital
Intercommunal de Creteil, Paris, France
— 1:00 SIG -Organizer. Quan Dong Nguyen.
Stanley M. Truhlsen Eye Institute, University of
Nebraska Medical Center, Omaha, NE *CR
— 1:55 Global Research in Ocular Infectious
Disease. Justine Smith. Flinders University,
Adelaide, SA, Australia
— 1:00 Comparison Study of En Face OCT
Angiography and Fluorescence Angiography
on Macular Choroidal Neovascularization. Min
Wang. Eye and ENT Hospital of Fudan University,
Shanghai, China
— 1:00 What Is a Desired Endpoint in the
Management of DME ? Quan Dong Nguyen.
University of Nebraska Medical Center, Omaha, NE
— 2:06 Global Eye Research Workshop. Paul
A. Sieving. National Eye Institute, Natoinal
Institutes of Health, Bethesda, MD
— 2:17 Global Research Partnerships &
Vision Loss Prevention Activities. Gyan Prakash.
National Eye Institute, NIH, Bethesda, MD
S 230A-D
Tuesday, May 06, 2014 1:00 PM-2:30 PM
355 En Face OCT imaging of the Eye
– SIG
Moderators: Bruno Lumbroso and
Philip J. Rosenfeld
The goal is to improve physicians’ ability to
assess, diagnose and treat glaucoma, retinal and
choroidal diseases by using en face OCT to identify
microstructural and angiographic features and their
distribution throughout the 3D scan that are not
available with standard cross-sectional display.
— 1:00 SIG -Organizer. Andre C. Romano.
Ophthalmology, UNIFESP-Paulista School of Med,
Americana, Brazil *CR
— 1:00 SIG - Organizer. David Huang. Oregon
Health & Science University, Portland, OR
— 1:00 Structural and angiographic changes
in central serous chorioretinopathy with En Face
OCT Doppler Angiography. Andre C. Romano.
UNIFESP-Paulista School of Med, Sao Paulo,
Brazil
S 310A-D
Tuesday, May 06, 2014 1:00 PM-2:30 PM
356 RPE autofluorescence in a new
light –SIG
Moderator: Christine A. Curcio
Highlighted by fundus autofluorescence, RPE
lipofuscin is thought key to AMD pathogenesis.
However, its accumulation is unrelated to cell
number and A2E content in aging human macula.
Hyperspectral imaging analysis indicates multiple
new compounds awaiting characterization.
— 1:00 SIG -Organizer. Christine A. Curcio.
Ophthalmology, Univ of Alabama at Birmingham,
Birmingham, AL
— 1:00 SIG - Organizer. Peter A. Campochiaro.
Johns Hopkins University, Baltimore, MD
— 1:00 What Are the Major Determinants
of Final Visual Outcome in Patients with
RVO? Peter A. Campochiaro. Johns Hopkins
University, Baltimore, MD
— 1:00 How Does One Handle Patients with
Neovascular AMD Who Have Persistent or
Recurrent Fluid Every Month Despite Monthly
Injections? Diana V. Do. University of Nebraska
Medical Center, Omaha, NE
— 1:00 Do Frequent Injections of Anti-VEGF
Agents Cause GA? Philip J. Rosenfeld. Bascom
Palmer Eye Institute, University of Miami, Miami,
FL
— 1:00 What Is the Role of Wide-angle Retinal
Imaging in the Management of Vaso-Occlusive
Diseases? Jeffrey S. Heier. Tufts University,
Boston, MA
— 1:00 Do You Consider Micropulse Laser for
DME? David M. Brown. Weil Cornell Medical
College, Houston, TX
— 1:00 Autofluorescence and RPE morphology
in AMD. Christine A. Curcio. Univ of Alabama at
Birmingham, Birmingham, GA
— 1:00 The single lipofuscin granule. Thomas
Ach. Univ of Alabama at Birmingham,
Birmingham, GA
— 1:00 Mapping RPE lipofuscin
composition. Zsolt Ablonczy. Medical University
of South Carolina, Charleston, SC
— 1:00 Hyperspectral imaging for fluorophor
discovery. Theodore Smith. Columbia University,
New York, NY
246
S 320AB
S 320GH
S 330CD
Tuesday, May 06, 2014 1:00 PM-2:30 PM
Tuesday, May 06, 2014 1:00 PM-2:30 PM
Tuesday, May 06, 2014 1:00 PM-2:30 PM
358 Nuclear receptors (NRs) in retinal
development and disease: identifying
new signaling pathways with
therapeutic potential – SIG
359 Long term career considerations
for graduate students – SIG
360 Non-Invasive Targeted Molecular
Imaging in the Living Eye – SIG
Moderators: Iok-Hou Pang and Neena B. Haider
Moderators: Mark E. Kleinman and
Ashwath Jayagopal
Moderators: Goldis Malek and Anand Swaroop
NRs regulate a sundry of biological and disease
processes and as such are ideal targets for drug
discovery. In this SIG we will discuss the role of
classical and orphan NRs in retinal development,
age-related macular degeneration and diabetic
retinopathy.
Career planning is an important step for beginning
career researchers but is often met with uncertainty.
Our aim is to initiate dialog, awareness and have
guidance towards options graduate students and
postdoctoral fellows may consider early on.
— 1:00 SIG - Organizer. Genea Edwards.
Biochemistry & Molecular Biology, University of
Miami Miller Medical School, Miami, FL
— 1:00 SIG - Organizer. Goldis Malek.
Ophthalmology and Pathology, Duke University,
Durham, NC *CR
— 1:00 SIG - Organizer. Teresia A. Carreon.
University of Miami Miller Medical School, Miami,
FL
— 1:00 SIG - Organizer. Anand Swaroop.
National Eye Institute, Bethesda, MD
— 1:00 Long term career considerations for
graduate students. Genea Edwards. University of
Miami Miller Medical School, Miami, FL
— 1:00 Introduction to nuclear
receptors. Anand Swaroop. National Eye Institute,
Bethesda, MD
— 1:00 A functional genomic perspective
on retinal nuclear hormone receptors. Seth
Blackshaw. Johns Hopkins University School of
Meicine, Baltimore, MD
— 1:00 Liver-X-Receptor as a therapeutic
target in diabetic retinopathy. Maria Grant.
Indiana University, Indianapolis, IN
— 1:00 Nuclear receptor involvement and
potential therapeutic targets in age-related
macular degeneration. Goldis Malek. Duke
— 1:00 Comparison & contrast between
industrial and academic careers. Iok-Hou Pang.
North Texas Eye Research Institute, Forth Worth,
TX
— 1:00 Stepping stones from graduate school
to running the show. Neena B. Haider. Schepens
Eye Research Institute, Boston, MA
— 1:00 Navigating the maze: preparing for a
career in academia. Nora B. Caberoy. University
of Nevada, Las Vegas, NV
— 1:00 Career Opportunities in Public Policy
and Non-Profits for Scientists. David H. Epstein.
NAEVR, Rockville, MD
— 1:00 SIG -Organizer. Mark E. Kleinman.
Ophthalmology & Visual Sciences, University of
Kentucky, Lexington, KY
— 1:00 SIG - Organizer. Ashwath Jayagopal.
Vanderbilt University Medical Center, Nashville,
TN
— 1:00 Novel monoclonal antibodies to C3d
for non-invasively monitoring the activity of
complement in retinal disease. Baerbel Rohrer.
Medical University of South Carolina, Charleston,
NC
— 1:00 Seeing cells in the living retina using
two-photon fluorescence imaging. Jennifer J.
Hunter. University of Rochester Medical Center,
Rochester, NY
— 1:00 The challenge of addressing
nanoparticles to receptors for cell
recognition. Achim Goepferich. University of
Regensburg, Regensburg, Germany
— 1:00 Targeted molecular imaging of the
retinal pigment epithelium. Mark E. Kleinman.
University of Kentucky, Lexington, KY
— 1:00 In vivo visualization of biomarkers
of retinal vascular disease. Ashwath Jayagopal.
Vanderbilt University Medical Center, Nashville,
TN
247
1:00 pm – 2:30 pm
— 1:00 Nuclear receptors in retinal cell type
differentiation. Douglas Forrest. National Institutes
— 1:00 Long term career considerations for
graduate students. Teresia A. Carreon. University
of Miami Miller Medical School, Miami, FL
This session will focus on approaches to develop
in vivo molecular imaging platforms with
focused discussions on using targeted fluorophore
conjugates, two-photon intravital microscopy, and
functionalized nanoparticles to visualize retinal
disease.
Tuesday – Workshop/SIGs
S 330GH
Tuesday, May 06, 2014 1:00 PM-2:30 PM
361 Contributions of neuronal and
vascular defects to early diabetic
retinopathy – SIG
Moderators: Erika D. Eggers and
Machelle T. Pardue
Diabetic retinopathy is clinically described as a
microvascular disease; however, recent work has
also documented neuronal defects. This SIG will
discuss the importance of neuronal and vascular
deficits in early diabetic retinopathy.
— 1:00 SIG - Organizer. Erika D. Eggers.
Physiology, University of Arizona, Tucson,
AZ; 2Biomedical Engineering, University of
Arizona, Tucson, AZ
— 1:00 SIG - Organizer. Machelle T. Pardue.
Emory University, Atlanta, Atlanta, GA
— 1:00 Vascular contributions to early diabetic
retinopathy. Ruth B. Caldwell. Georgia Regents
University, Augusta, GA
1:00 pm – 2:30 pm
— 1:00 Early dysfunction in diabetic
retinopathy. Marcus A. Bearse. University of
California, Berkeley, CA
— 1:00 Neuronal deficits in early diabetic
retinopathy. Machelle T. Pardue. Emory
University, Atlanta, GA
248
Tuesday – All Posters
Exhibit/Poster Hall SA
Tuesday, May 06, 2014 2:45 PM-3:45 PM
363 All Posters / Networking
All Posters
2:45 pm – 3:45 pm
249
S 210DE
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Visual Neuroscience
364 Leading Edge — New Directions in
the Analysis of Retinal Image Motion Minisymposium
Direction selectivity of certain retinal ganglion
cells and the associated neural circuits has been a
prime subject for visual neuroscience research for
many decades. In recent years, the development of
new technologies, coupled with the ability to target
specific subtypes of DS cells, has greatly advanced
our understanding of synaptic mechanisms,
developmental processes, and physiological
functions of DS cells and related circuits. This
minisymposium will survey new understanding
and residual controversy in this area of retinal
neurobiology.
Moderators: Jonathan B. Demb and
David M. Berson
3521 — 3:45 An anatomical basis of directionselectivity in the mouse retina. Kevin L.
Briggman. NINDS, NIH, Bethesda, MD
Tuesday Papers/
Minisymposium
3:45 pm – 5:30 pm
3522 — 4:06 Role of the starburst network in
direction selectivity and beyond. Jimmy Zhou.
Yale University, New Haven, CT
3523 — 4:27 Electrical signalling in superior
coding ON OFF DSGC. Gautam Awatramani.
Biology, University of Victoria, Victoria, BC,
Canada
3524 — 4:48 Adaptation in direction selective
responses. Marla Feller. Molecular and Cell
Biology and Helen Wills Neuroscience Institute,
University of California, Berkeley, Berkeley, CA
3525 — 5:09 Cell types and transsynaptic circuits for processing directional
motion. Andrew Huberman. University of
California, San Diego, San Diego, CA
S 230A-D
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Retina
365 Drusen and drusenoid structures
Moderators: Anita Agarwal, Amani A. Fawzi and
Richard F. Spaide
3527 — 4:00 Reticular Pseudodrusen
Associated with Bruch’s Membrane Pathology in
Pseudoxanthoma Elasticum. Martin Gliem1, R. P.
Finger1, 2, F. G. Holz1, P. Charbel Issa1.1Department
of Ophthalmology, University of Bonn, Bonn,
Germany; 2Centre for Eye Research Australia,
Royal Victorian Eye and Ear Hospital, University of
Melbourne, Melbourne, VIC, Australia *CR
3528 — 4:15 Comparison of standardized
color photography grading and SDOCT volume
analysis to predict 2-year progression from
intermediate to advanced age-related macular
degeneration. Francisco A. Folgar1, M. B.
Sevilla1, V. Tai1, T. E. Clemons3, R. P. Danis2, E.
Y. Chew4, S. Farsiu1, C. A. Toth1. 1Ophthalmology,
Duke University Eye Center, Durham,
NC; 2Ophthalmology, University of Wisconsin,
Madison, WI; 3The EMMES Corporation,
Rockville, MD; 4National Eye Institute, National
Institutes of Health, Bethesda, MD *CR, f
3529 — 4:30 Progression of subretinal
drusenoid deposits (SDD) in AMD revealed by
adaptive optics laser scanning ophthalmoscopy
(AOSLO). Xiaolin Wang1, P. Godara1, T. Zhang2, 1,
A. Meadway1, M. E. Clark1, C. Witherspoon1,
C. A. Girkin1, C. Owsley1, C. A. Curcio1, Y.
Zhang1, 2. 1Ophthalmology, University of Alabama
at Birmingham, Birmingham, AL;2Biomedical
Engineering, University of Alabama at Birmingham,
Birmingham, AL
3530 — 4:45 Drusen volume progression and
the Development of neovascular Age-related
Macular Degeneration. Ferdinand G. Schlanitz1,
B. Baumann2, A. Montuoro3, U. Scheschy1, A.
Shahlaee1, M. Baratsits1, T. J. Mittermüller1,
M. Pircher2, C. K. Hitzenberger2, U. SchmidtErfurth1. 1Ophthalmology, Medical University
of Vienna, Vienna, Austria; 2Center for Medical
Physics and Biomedical Engineering, Medical
University of Vienna, Vienna, Austria; 3Vienna
Reading Center, Department of Ophthalmology,
Medical University of Vienna, Vienna, Austria *CR
3531 — 5:00 Assessment of the Relationship
Between Choroidal Thickness and Drusen
Burden in Non-neovascular Age-related Macular
Degeneration. Jaehong Han1, 2, S. Sharma2, P.
K. Kaiser2, J. P. Ehlers2. 1Case Western Reserve
University School of Medicine, Cleveland Heights,
OH; 2Cole Eye Institute, Cleveland Clinic,
Cleveland, OH *CR
3532 — 5:15 Longitudinal structure function
analysis in reticular pseudodrusen. Florian Alten,
P. Heiduschka, C. R. Clemens, N. Eter. University
Eye Hosp Muenster, Muenster, Germany *CR
3526 — 3:45 Calcified Drusen: Multimodal
Clinical Imaging and Histology. Mihoko Suzuki1,
S. Ooto1, C. A. Curcio2, R. F. Spaide1. 1Vitreous
Retina Macula Consultants of New York, New
York, NY; 2Ophahtlmology, University of Alabama,
Birmingham, AL *CR
S 230EF
Tuesday, May 06, 2014 3:45 PM-5:30 PM
366 Visual function in eye disease
Moderators: Daniel R. Coates and
Michael Kalloniatis
3533 — 3:45 Optimal stimulus placement
for psychometric function estimation. Daniel
R. Coates, S. T. Chung. Vision Science Graduate
Group, UC Berkeley, Berkeley, CA
3534 — 4:00 A Paradigm Shift in Visual
Field Testing Using White-on-White Standard
Automated Perimetry (SAP). Michael
Kalloniatis1, S. Khuu2. 1School of Optometry
& Vision Science and Centre for Eye Health,
University of New South Wales, Sydney 2052,
NSW, Australia; 2School of Optometry and Vision
Science, University of New South Wales, Sydney
2052, NSW, Australia *CR
3535 — 4:15 Novel psychophysical approaches
identify impairment of motion, achromatic
and chromatic discrimination in early diabetic
retinopathy. Miguel Castelo-Branco, B. Quendera,
M. Al-Rawi, S. Ferreira. IBILI, Institute for
Biomedical Imaging in Life Sciences, Coimbra,
Portugal
3536 — 4:30 A Universal Colour
Discrimination Test suitable for observers with
low vision. Caterina Ripamonti1, S. Kalwarowsky1,
M. Nardini1, 2. 1Institute of Ophthalmology,
Kingdom; 2Department of Psychology, Durham
University, Durham, United Kingdom
3537 — 4:45 On-road Driving Performance
in Older Adults with Glaucoma. Joanne
M. Wood1, A. A. Black1, P. Lacherez1, K.
Mallon1, R. Thomas2, 3, C. Owsley4. 1School
of Optometry and Vision Science, Queensland
University of Technology, Brisbane, QLD,
Australia; 2Queensland Eye Institute, Brisbane,
QLD, Australia; 3University of Queensland,
Brisbane, QLD, Australia; 4Department of
Ophthalmology, University of Alabama at
Birmingham, Birmingham, AL
3538 — 5:00 Longitudinal Changes
in Microperimetric Retinal Sensitivity
in Intermediate Age-Related Macular
Degeneration. Zhichao Wu, C. D. Luu, L. N.
Ayton, R. H. Guymer. Centre for Eye Research
Australia, University of Melbourne, Royal Victorian
Eye and Ear Hospital, East Melbourne, VIC,
Australia
250
S 230GH
S 310A-D
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Neuro-Ophthalmology
Glaucoma
367 Neuro-ophthalmology
368 Glaucoma Pharmacology and
clinical studies
Moderators: Steven A. Newman and
Mark J. Kupersmith
Moderators: Tina Wong and Paul L. Kaufman
3539 — 3:45 A New Automated 20 Second
Pupillographic Test to Quantify the Log
Unit Relative Afferent Pupillary Defect
and its Relationship to Retinal Ganglion
Cell Thickness. Randy H. Kardon1, 2, P.
Poolman2, 1, J. N. Pienta1, J. M. Full2, S. C.
Anderson2. 1Ophthalmology and Visual Sciences,
University of Iowa, Iowa City, IA; 2Iowa City
VA Center of Excellence for the Prevention and
Treatment of Visual Loss, Iowa City VA Medical
Center, Iowa City, IA *CR
3540 — 4:00 Inner and outer retinal
dysfunction in idiopathic intracranial
hypertension. Heather Moss, J. C. Park, J.
McAnany. Ophthalmology and Visual Sciences,
University of Illinois at Chicago, Chicago, IL
3541 — 4:15 Quantitative Assessment of
Venous Stenting in IIH. Steven A. Newman.
Ophthalmology, University of Virginia,
Charlottesville, VA
3543 — 4:45 Baseline Optical Coherence
Tomography (OCT) of Participants in the
Idiopathic Intracranial Hypertension Treatment
Trial: Correlations and Relationships to
Clinical Features. Mark J. Kupersmith. NeuroOphthalmology, Roosevelt Hospital and NYEE,
New York, NY f
3544 — 5:00 Classification of Baseline VIsual
FIeld Results in the Idiopathic Intracranial
Hypertension Treatment Trial (IIHTT). Chris
A. Johnson1, J. L. Keltner2, M. Wall3, K. E.
Cello2. 1Ophthal & Visual Sci, University of Iowa,
Iowa City, IA; 2Department of Ophthalmology
and Visual Sciences, University of California,
Davis, Davis, CA; 3Departments of Neurology and
Ophthalmology, University of Iowa, Iowa CIty,
IA f
3545 — 5:15 The Idiopathic Intracranial
Hypertension Treatment Trial: a Multicenter,
Double-Blind, Randomized Clinical Trial
Comparing Acetazolamide and Placebo on
Visual Outcome. Michael Wall. Neurology &
Ophthalmology, Univ of Iowa, Carver Coll of Med,
Iowa City, IA f
3547 — 4:00 Ocular hypotensive effects of the
KATP channel opener cromakalim in murine and
human experimental model systems. Uttio Roy
Chowdhury, C. K. Bahler, B. H. Holman, M. P.
Fautsch. Ophthalmology, Mayo Clinic, Rochester,
MN
3548 — 4:15 Preclinical Evaluation of ENV515
(travoprost) Intracameral Implant - Clinical
Candidate for Treatment of Glaucoma Targeting
Six-Month Duration of Action.Tomas Navratil1,
A. Garcia1, J. Tully1, B. Maynor1, I. K. Ahmed4,
D. L. Budenz5, R. A. Lewis2, S. L. Mansberger3,
B. C. Gilger6, B. R. Yerxa1. 1Envisia Therapeutics,
Research Triangle Park, NC; 2Sacramento Eye
Consultants, Sacramento, CA; 3Devers Eye
Institute, Portland, OR; 4University of Toronto,
Toronto, ON, Canada; 5University of North
Carolina, Chapel Hill, NC;6North Carolina State
University, Raleigh, NC *CR
3549 — 4:30 Efficacy of Latanoprostene Bunod
Ophthalmic Solution 0.024% Compared With
Timolol Maleate Ophthalmic Solution 0.5% in
Lowering IOP over 24 hours in Subjects With
Open Angle Glaucoma or Ocular Hypertension
(CONSTELLATION). John H. Liu1, J. L.
Vittitow2, Q. Ngumah2, R. N. Weinreb1. 1Dept
of Ophthalmology and Hamilton Glaucoma
Center, Univ of California, San Diego, La Jolla,
CA; 2Bausch & Lomb, Madison, NJ *CR, f
3550 — 4:45 Observation periods of 1 year
for clinical trials of neuroprotective agents
in glaucoma are feasible. David F. GarwayHeath1, H. Zhu1, 2, D. P. Crabb2. 1Institute of
Ophthalmology, University College London,
London, United Kingdom; 2Optometry and Visual
Science, City University London, London, United
Kingdom *CR, f
3552 — 5:15 Evaluation of the Retinal
Hemodynamics in Patients with Primary Open
Angle Glaucoma and Differing Nocturnal Blood
Pressure Profiles. Firdaus Yusof1, 2, R. Cheng3, N.
Espahbodi3, L. Khuu3, Y. M. Buys3, G. E. Trope3, C.
Hudson1, 3, J. G. Flanagan1, 3. 1School of Optometry
and Vision Science, University of Waterloo,
Waterloo, ON, Canada;2Department of Optometry
and Visual Science, International Islamic University
of Malaysia, Kuantan, Malaysia; 3Department of
Ophthalmology and Vision Sciences, University of
Toronto, Toronto, ON, Canada *CR
S 310E-H
Tuesday, May 06, 2014 3:45 PM-5:30 PM
369 Pathophysiology of AMD and
retinopathies
Moderator: David R. Hinton
3553 — 3:45 IL18 is not therapeutic for
neovascular age-related macular degeneration.
Bradley D. Gelfand1, 2, Y. Hirano1, T. Yasuma1,
T. Mizutani1, B. J. Fowler1, M. Nozaki4, H.
Kaneko5, B. Ambati6, 7, D. R. Hinton8, J.
Ambati1, 3. 1Ophthalmology & Visual Sciences,
University of Kentucky, Lexington, KY;
2
Biomedical Engineering, University of Kentucky,
Lexington, KY; 3Physiology, University of
Kentucky, Lexington, KY; 4Ophthalmology
and Visual Science, Nagoya City University
Graduate School of Medical Sciences, Nagoya,
Japan; 5Ophthalmology, Nagoya University
Graduate School of Medicine, Nagoya, Japan;
6
Ophthalmology and Visual Sciences, Moran Eye
Center, University of Utah School of Medicine, Salt
Lake City, UT;7Ophthalmology, Veterans Affairs
Salt Lake City Healthcare System, Salt Lake City,
UT; 8Pathology and Ophthalmology, Keck School of
Medicine of the University of Southern California,
Los Angeles, CA *CR
3554 — 4:00 Evaluation of dosage dependent
effects of subretinally administered Sodium
Iodate - a new model for dry AMD? Michael J.
Koss1, 2, H. Nazari Khanamiri1, 2, D. Matsunaga2,
M. Pfister1, W. F. Abdallah1, 3, Y. Zhang1, 2, M.
S. Humayun1, 2, D. R. Hinton2. 1Ophthalmology,
Doheny Eye, Pasadena, CA; 2Ophthalmology,
CA; 3Ophthalmology, Zagazig University, Zagazig,
Egypt
251
Tuesday Papers
Minisymposium
3:45 pm – 5:30 pm
3542 — 4:30 A Prospective Trial of Transverse
Sinus Stenting for Idiopathic Intracranial
Hypertension. Marc Dinkin1, F. Laage-Gaupp2,
A. Patsalides2. 1Ophthalmology and Neurology,
NY; 2Neurosurgery, Weill Cornell Medical College,
New York, NY f
3546 — 3:45 Dissection of a QTL Locus
on Mouse Proximal Chromosome 5 that
Modulates Intraocular Pressure (IOP) leads
to Identification of a Potential New Drug
Target for Glaucoma. Shankar Swaminathan1,
H. Lu1, 2, J. L. Wiggs3, R. W. Williams2, L. Lu2,
M. M. Jablonski1, 2. 1Ophthalmology, Hamilton
Eye Institute, The University of Tennessee Health
Science Center, Memphis, TN; 2Anatomy &
Neurobiology, The University of Tennessee Health
Science Center, Memphis, TN; 3Ophthalmology,
Harvard Medical School, Massachusetts Eye and
Ear Infirmary, Boston, MA *CR
3551 — 5:00 The Relationship between
Intraocular Pressure and Rates of Estimated
Retinal Ganglion Cell Loss in Glaucoma. Amir
Marvasti1, 2, A. J. Tatham1, L. M. Zangwill1, R. N.
Weinreb1, F. A. Medeiros1. 1Hamilton Glaucoma
Center, Department of Ophthalmology, University
of California, San Diego, San Diego, CA; 2Boston
University School of Medicine, Boston,
MA *CR, f
3555 — 4:15 Histological Evidence of Outer
Retinal Atrophy Associated with Geographic
Atrophy Secondary to Age-related Macular
Degeneration. Richard F. Spaide1, 2, C. A.
Curcio2, S. Ooto1, M. Suzuki1. 1Vitreous Retina
Macula Consultants of New York, New York,
NY; 2Department of Ophthalmology, University of
Alabama at Birmingham, Birmingham, AL *CR
3556 — 4:30 Control of physiological and
pathological angiogenesis in the retina by
the matricellular protein CCN1. Brahim
Chaqour1, 2, M. Grant3, J. Choi1, I. Krupska1, L.
Yan1, H. Chintala1. 1Cell Biology, SUNY Eye
Institute Downstate Medical Center, Brooklyn,
NY; 2Ophthalmology, SUNY Downstate Medical
Center, Brooklyn, NY; 3Ophthalmology, Indiana
University, Indianapolis, IN
Tuesday Papers/
Minisymposium
3:45 pm – 5:30 pm
3557 — 4:45 Mechanistic role of arginase
in inducing endothelial cell senescence in
diabetic retinopathy. Esraa Shosha1, T. Lemtalsi1,
Z. Xu1, R. Caldwell2, R. B. Caldwell1, 3, S.
Narayanan1. 1Vascular Biology Center, Georgia
Regents University, Augusta, GA; 2Department of
Pharmacology and Toxicology, Georgia Regents
University, Augusta, GA; 3VA Medical Center,
Augusta, GA
3558 — 5:00 Adiponectin mediates protective
effect of omega-3 long-chain polyunsaturated
fatty acid in retinal neovascularization. Zhongjie
Fu1, C. Lofqvist2, C. G. Hurst1, Z. Cui1, L.
P. Evans1, K. T. Tian1, H. H. Bogardus1, J.
Chen1, A. Hellström2, L. Smith1. 1Department
of Ophthalmology, Children’s Hosp Boston/
Harvard Med Sch, Boston, MA; 2Department
of Ophthalmology, Sahlgrenska Academy at
University of Gothenburg, Gothenburg, Sweden
3559 — 5:15 The role of IL-1β in progressive
retinal degeneration associated with retinopathy
of prematurity. Tianwei (Ellen) Zhou1, J. C.
Rivera2, I. Lahaie2, Z. Shao2, T. Zhu2, B. Noueihed1,
A. Polosa3, A. L. Dorfman3, P. Lachapelle3, S.
Chemtob2. 1Pharmacology and Medicine, McGill
University, Montreal, QC, Canada; 2Pediatrics,
Ophtalmology and Pharmacology, University of
Montreal, Montreal, QC, Canada; 3Neurosciences
and Ophthalmology, McGill University, Montreal,
QC, Canada
S 320CD
S 330EF
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Clinical/Epidemiologic Research
Lens
370 Eye-Health and Nutrition: From
Cradle to Grave - Minisymposium
371 Lens cell survival, development,
and aging
Good vision and visual function is important for
everyday tasks everywhere in the world. Our
understanding of what can be done via nutrition
to influence lifelong eye-health is growing. This
session will address several aspects of nutrition and
eye health: from early development through to the
very elderly, using basic science, epidemiology and
imaging to illustrate what we know and illustrate
where the gaps in knowledge are.
Moderators: Alan Shiels and Paul FitzGerald
Moderators: Tunde Peto and Caroline C. Klaver
3560 — 3:45 The global burden of vision
impairment and blindness: how the causespecific burden has changed over the past 30
years and the new initiative to make this data
accessible: the Global Vision Database. Rupert
Bourne. Vision & Eye Research Unit, Anglia
Ruskin University, Cambridge, United Kingdom
3562 — 4:02 Zinc in the eye and the visual
pathway. Imre Lengyel. Ocular Biology and
Therapeutics, UCL Institute of Ophthalmology,
London, United Kingdom *CR
3563 — 4:19 Lutein and Zeaxanthin for
Ocular Health: They’re Not Just for AMD
Anymore. Paul S. Bernstein. Ophthal and Visual
UT *CR
3564 — 4:36 How does lifelong nutrition affect
eye-health? - lessons learned from studies on the
very elderly. Cecile Delcourt. Universite Bordeaux
Segalen, INSERM, Bordeaux, France *CR
3565 — 4:53 Studying Eye Disease, there’s
an App for that! - New smartphone technology
for ophthalmic epidemiological studies. Andrew
Bastawrous. International Centre for Eye Health,
Londons School of Hygiene and Tropical Medicine,
Goring, United Kingdom *CR
— 5:10 Discussion
3566 — 3:45 Knockdown of RanGAP1 leads
to apoptosis by inducing mitotic defects in lens
epithelial cells. Weike Ji. 1ophthalmology and
visual sciences, university of Nebraska medical
center, omaha, NE; 2Biochemistry & Molecular
Biol, Univ of Nebraska Med Center, Omaha, NE
3567 — 4:00 SUMO-Conjugated RanGAP1
Plays A Role in Autophagy of both Lens
Epithelial and Retinal Pigment Epithelial
Cells. David W. Li1, 2, W. Ji1, X. Hu1, 3, W.
Hu1, 3, X. Tang2, 1, F. Liu2, Z. Luo2, Q. Nguyen1,
Y. Liu2. 1Ophthalmology & VIsual Sciences,
University of Nebraska Medical Center, Omaha,
NE; 2Zhongshan Ophthalmic Center, Sun Yat-sen
University, Guanzhou, China; 3College of Life
Sciences, Hunan Normal University, Chansha,
China
3568 — 4:15 Lens epithelial cells use
phagocytosis as a mechanism to remove
apoptotic cellular debris. Daniel Chauss, L.
A. Brennan, B. Teng, M. Kantorow. Biomedical
Sciences, Florida Atlantic University, Boca Raton,
FL
3569 — 4:30 Prdx6 with Disrupted
Sumoylation Sites, K122/142R Gains Function
in Protecting Lens Epithelial Cells and Lenses
by Abrogating Oxidative Stress-Induced
Aberrant Sumoylation Signaling. Dhirendra P.
Singh1, B. Chhunchha1, E. Kubo2. 1Ophthalmology
and Visual Sciences, Univ of Neb Med Center,
Omaha, NE; 2Ophthalmology, Kanazawa Medical
University, Kanazawa, Japan
3570 — 4:45 Inactivation of Glycogen
Synthase Kinase-3beta (GSK-3β) Elicits a
Disadvantageous Relationship Between EMT
and Lens Mitoprotection via Nuclear β-Catenin.
Patrick R. Cammarata, S. Neelam, M. M. Brooks.
Cell Biology & Anatomy, University of North Texas
Health Science Center, Fort Worth, TX
3571 — 5:00 Parkin regulates mitochondrial
quality control in oxidative stress-treated lens
epithelial cells through mitophagy. Lisa A.
Brennan1, D. Chauss1, S. Basu2, A. S. Menko2, M.
Kantorow1. 1Biomedical Sciences, Florida Atlantic
University, Boca Raton, FL; 2Anatomy, Thomas
Jefferson University, Philadelphia, PA
252
3572 — 5:15 Age-related changes in
composition and geographic distribution
of phospholipids in zebrafish lens. Stephen
Barnes1, M. Collier3, S. Watts2, D. E. Graves3, J.
H. Kabarowski4. 1Pharmacology & Toxicology,
Univ of Alabama at Birmingham, Birmingham,
AL; 2Department of Biology, University of Alabama
at Birmingham, Birmingham, AL;3Department of
Chemistry, University of Alabama at Birmingham,
Birmingham, AL; 4Department of Microbiology,
University of Alabama at Birmingham,
Birmingham, AL
S 330GH
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Immunology/Microbiology
372 Inflammatory Tissue Damage and
Immunoregulation
3578 — 5:00 Modulation of Cytoskeletal
Adaptor Proteins in Uveal Melanoma to Control
Metastasis. Vanessa M. Morales1, 2, R. Yates3, 1, J. J.
Toutounchian3, M. W. Kibe1, D. Miller3, Y. Jiang1,
J. J. Steinle1, 4, P. R. Mendoza5, H. E. Grossniklaus5,
M. W. Wilson1. 1Ophthalmology, Hamilton Eye
Institute, University of Tennessee Health Science
Center, Memphis, TN;2Microbiology, Immunology
and Biochemistry, University of Tennessee Health
Science Center, Memphis, TN; 3Pharmaceutical
Sciences, University of Tennessee Health Science
Center, Memphis, TN; 4Anatomy and Neurobiology,
University of Tennessee Health Science Center,
Memphis, TN; 5Ophthalmology, Emory University,
Atlanta, GA
3579 — 5:15 Retinal Laser Burn (RLB) alter
inflammatory Toll-like receptors (TLRs) in
the retina in a Substance P dependent manner.
Toan Phan, J. Stein-Streilein. Department of
Ophthalmology, Schepens Eye Research Institute/
Mass Eye and Ear/Harvard Medical School, Boston,
MA
Moderators: Andrew W. Taylor and Victor L. Perez
3573 — 3:45 Distinct Role of Donor CD4 T
Cells in the Orchestration and Development of
Ocular Graft versus Host Diseases. Victor L.
Perez1, 2, S. Herretes1, S. Duffort1, H. Barreras2,
R. Levy1, 2. 1Ophthalmology, Bascom Palmer
Eye Institute, University of Miami Miller School
of Medicine, Miami, FL; 2Immunology and
Microbiology, University of Miami Miller School
of Medicine, Miami, FL *CR
3575 — 4:15 Resolvin D1 (RvD1) promotes the
resolution of inflammation and protects mice
from S. aureus endophthalmitis via Toll-Like
Receptor 2 signaling. Pawan Kumar Singh, A.
Kumar, A. Kumar. Kresge Eye Institute, Wayne
State University School of Medicine, Detroit, MI
3576 — 4:30 Similarities of human EMR2 to
mouse F4/80 in ocular tolerance. Helen Song1,
S. Gordon2, J. Stein-Streilein1. 1Schepens Eye
Research Institute, Boston, MA; 2Sir William Dunn
School of Pathology, University of Oxford, Oxford,
United Kingdom
3577 — 4:45 The Membrane-associated Mucins
MUC1 and MUC16 Suppress Toll-like Receptormediated Innate Immune Responses at the
Ocular Surface. Balaraj B. Menon, C. Marko, S.
Spurr-Michaud, A. Tisdale, I. K. Gipson. Harvard
Med Sch-Ophthal, Schepens Eye Rsch Inst, MEE,
Boston, MA
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Cornea
373 Corneal endothelium
Moderators: Ula Jurkunas, Albert S. Jun and
Shigeru Kinoshita
3584 — 4:45 Menadione Induces Endothelial
Mesenchymal Transition in Human Corneal
Endothelial Cells. Duna Raoof1, K. Katikireddy2,
T. Schmedt3, U. Jurkunas1. 1Cornea, Massachusetts
Eye and Ear Infirmary, Boston, MA; 2Schepens
Eye Research Institute, Boston, MA; 3NBE
Analytical, AbbVie Deutschland GmbH & Co. KG,
Ludwigshafen, Germany
3585 — 5:00 Comparing the Transcriptome
of Ex Vivo Endothelium with Cultured Human
Corneal Endothelial Cells. Ricardo F. Frausto, A.
J. Aldave. Doris Stein, Cornea Division, Jules Stein
Eye Institute, UCLA, Los Angeles, CA
3586 — 5:15 Fuchs Corneal Dystrophy in
African Americans. Allen Eghrari, J. Gottsch.
Department of Ophthalmology, Divison of Cornea,
Anterior Segment and External Diseases, Johns
Hopkins University School of Medicine, Baltimore,
MD
3580 — 3:45 Anterior Corneal Aberrations
in Relation to Severity of Fuchs Endothelial
Dystrophy. Sanjay V. Patel, S. Amin, K. H. Baratz,
K. M. Kane, J. W. McLaren. Ophthalmology, Mayo
Clinic, Rochester, MN *CR
3581 — 4:00 In vivo functionality of a
corneal endothelium reconstituted by injection
of endothelial cells in the anterior chamber
of a feline model. Cristina Bostan1, 2, M.
Theriault3, 4, K. Forget1, M. Bareille1, A. Deveault1,
S. Proulx3, 4, I. Brunette1, 2. 1MaisonneuveRosemont Hospital Research Center, Montreal,
QC, Canada; 2Ophthalmology, University of
Montreal, Montreal, QC, Canada; 3LOEX/CUOResearch, CHUQ Research Center, Quebec, QC,
Canada; 4Ophthalmology, University of Laval,
Quebec, QC, Canada
3582 — 4:15 ROCK-inhibiter Suppressed
Apoptosis of Corneal Endothelial Cells by
Inhibiting Membrane Blebbing. Keita Fujii1, N.
Okumura1, 2, E. P. Kay1, M. Nakahara1, A. Odajima1,
M. Ueno2, S. Kinoshita2, N. Koizumi1. 1Biomedical
Engineering, Doshisha University, Kyotanabe,
Japan; 2Ophthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan*CR
253
Tuesday Papers
Minisymposium
3:45 pm – 5:30 pm
3574 — 4:00 Melanocortin Receptor
Stimulation Induces CD4+CD25+NRP-1- Treg
cells to Suppress Experimental Autoimmune
Uveitis. Darren J. Lee, A. W. Taylor.
Ophthalmology, Boston University School of Med,
Boston, MA
S 331A-D
3583 — 4:30 The involvement of
transforming growth factor beta in excessive
extracellular matrix production of corneal
endothelial cells in Fuchs’ endothelial corneal
dystrophy. Noriko Koizumi1, N. Okumura1, 2,
L. Ho1, E. P. Kay1, S. Kawasaki2, T. Tourtas3,
U. Schlotzer-Schrehardt3, F. E. Kruse3, S.
Kinoshita2. 1Biomedical Engineering, Doshisha
University, Kyotanabe City, Japan; 2Ophthalmology,
Kyoto Prefectural University of Medicine, Kyoto,
Japan; 3Ophthalmology, University of ErlangenNürnberg, Erlangen, Germany *CR
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Anatomy/Pathology
374 Myopia
Moderator: Michael R. Frost
3587 — A0036 Relationship between axial
length and 64 cells retinal thickness or optic discto-fovea angle in young healthy eyes. Takehiro
Yamashita, T. Sakamoto, Y. Kii, M. Tanaka, K.
Nakao. Ophthalmology, Kagoshima University,
Kagoshima, Japan f
Tuesday Posters
3:45 pm – 5:30 pm
3588 — A0037 Genome-wide scleral microand messenger-RNA profiling in the mouse
myopia model. Ravi Metlapally1, H. Park2, K.
Wang1, C. C. Tan2, J. G. Light2, M. T. Pardue2, 3, C.
Wildsoet1, 4. 1Optometry, UC Berkeley, Berkeley,
CA; 2Ophthalmology, Emory University, Atlanta,
GA; 3Rehab R&D Center of Excellence, Atlanta
VA Medical Center, Atlanta, GA; 4Vision Science
Graduate Group, UC Berkeley, Berkeley, CA
3589 — A0038 Spatial and temporal mapping
of retinal sublayer and choroidal thicknesses in
the chick using 3-dimensional segmentation with
optical coherence tomography imaging. Diane
Nava1, 4, A. Raman1, C. Nieuwenhuis2, A. NunezElizalde3, C. Wildsoet1, 4. 1Vision Science Group,
UC Berkeley, Berkeley, CA; 2Department of
Computer Science, Technische Universität
München, Garching, Germany; 3Helen Wills
Neuroscience Institute, UC Berkeley, Berkeley,
CA; 4Center for Eye Disease and Development, UC
Berkeley, Berkeley, CA
3590 — A0039 Chick Retinal Pigment
Epithelium Responds to Imposed Defocus in
Minutes. Yan Zhang, A. Truong, F. Zhao, C.
Wildsoet. Center for Eye Disease & Development,
School of Optometry, Univ of California, Berkeley,
Berkeley, CA
3591 — A0040 Quantitative analysis of
tessellated fundus and its association with
choroidal thickness in healthy eyes. Naoya
Yoshihara, T. Yamashita, Y. Kii, M. Tanaka, K.
Nakao, T. Sakamoto. Ophthalmology, Kagoshima
University, Kagoshima, Japan f
3592 — A0041 Is Retinal Shape different
in Asians and Caucasians? Estimation from
Peripheral Refraction and Peripheral Eye
Length Methods. Pavan K. Verkicharla1, D.
A. Atchison1, M. Suheimat1, K. L. Schmid1,
A. Mathur1, E. A. Mallen2, X. Wei3, N. A.
Brennan3. 1School of Optometry & Vision Science,
Institute of Health & Biomedical Innovation,
Queensland University of Technology, Brisbane,
QLD, Australia; 2School of Optometry and Vision
Science, University of Bradford, Bradford, United
Kingdom; 3Johnson & Johnson Vision Care, Inc.,
Jacksonville, FL *CR
3593 — A0042 Identification of integrin
receptor subunits in the guinea pig sclera. Kevin
Wang1, R. Metlapally1, C. Wildsoet1, 2. 1School
of Optometry, University of California Berkeley,
Berkeley, CA; 2Vision Science Graduate Group,
University of California Berkeley, Berkeley, CA
3601 — A0050 Comprehensive lesions of the
retina surrounding the optic nerve enhance
elongation and cause myopia in the guinea pig
eye. Sally A. McFadden, C. Medcalf, G. Zeng, J.
Holdsworth. Faculty of Science and IT, University
of Newcastle, Callaghan, NSW, Australia
3594 — A0043 Changes in mRNA expression
of Endothelial Growth Factor A, C, D and
Vascular Endothelial Growth Factor Receptor
1, 2, 3 during induction of deprivation myopia
in chickens. Marita P. Feldkaemper, F. Schaeffel.
Centre for Ophthalmology, Institute for Ophthalmic
Research, Tuebingen, Germany
3602 — A0051 Longitudinal changes in
corneal power and axial length in the Correction
of Myopia Evaluation Trial (COMET)
Cohort. Mitchell Scheiman1, L. Deng3, J. E.
Gwiazda3, Q. Zhang2, R. E. Manny4, K. D. Fern4, E.
Weissberg3. 1Coll of Optometry, Salus University,
Elkins Park, PA; 2Department of Preventive
Medicine, Stony Brook University Medical Center,
Stony Brook, NY; 331 New England College of
Optometry, Boston, MA; 4College of Optometry,
University of Houston, Houston, TX f
3595 — A0044 The association between initial
choroid thickness and subsequent ocular growth
rate in young chicks: Evidence for different
choroidal mechanisms in growth inhibition vs
stimulation. Kristen Totonelly, X. Zhu, P. Thai, R.
Zanzerkia, D. L. Nickla. New England College of
Optometry, Boston, MA
3596 — A0045 Gaze-Induced Axial Length
Changes in Highly Myopic Eyes as Gauged
by Magnetic Resonance Imaging. Quan V.
Hoang1, J. Tang1, J. Goldman1, J. Y. Pan2, 1, S.
Chang1. 1Ophthalmology, Harkness Eye Institute,
Columbia University, New York, NY; 2Methodist
Girls’ School, Singapore, Singapore *CR
3597 — A0046 Lack of oblique peripheral
astigmatism in the chicken eye, comparison to
the human eye and possible consequences for
emmetropization. Felix Maier1, A. Ohlendorf2,
S. Wahl2, F. Schaeffel1. 1Institute for Ophthalmic
Research, Section for Neurobiology of the Eye,
Tuebingen, Germany; 2Institute for Ophthalmic
Research, ZEISS Vision Science Lab, Tuebingen,
Germany *CR
3598 — A0047 Blue light protects against
temporal frequency dependent refractive
changes. Stephanie Britton, S. Hanowsky, F. J.
Rucker. Biomedical Science and Disease, New
England College of Optom., Boston, MA
3599 — A0048 The effect of near additions
and prismatic lenses on accommodative microfluctuations in Chinese myopic children. Huiling
Lin1, 3, D. Björn2, 3, L. Meng1, 3, J. Wanqing1, 3,
C. Yunyun1, 3. 1School of Optometry and
Ophthalmology, Wenzhou Medical University,
Wenzhou, China; 2R&D Optics Asia, Essilor
International, Wenzhou, China; 3WEIRC (WMUEssilor International Research Centre), Wenzhou,
China *CR
3600 — A0049 Transient changes in choroidal
thickness to different levels of imposed myopic
defocus. Jinhua Bao1, 3, B. Drobe2, 3, K. Chen1, 3,
H. Chen1, 3. 1School of Ophthalmology and
Optometry, Wenzhou Medical University, Wenzhou,
China; 2R&D Optics Asia, Essilor International,
Wenzhou, China; 3WEIRC, WMU-Essilor
International Research Centre, Wenzhou Medical
University, Wenzhou, China *CR
3603 — A0052 The effects of the relative
strength of simultaneous competing defocus
signals on emmetropization in infant rhesus
monkeys. Baskar Arumugam1, 2, L. Hung1, 2, C. To3,
E. L. Smith1, 2. 1College of Optometry, University
of Houston, Houston, TX; 2Vision CRC, Sydney,
NSW, Australia; 3Center for Myopia Research
School of Optometry, Hong Kong Polytechnic
University, Hung Hom, Hong Kong *CR
3604 — A0053 Both Lens Induced Hyperopia
and Recovery Increase the Amplitude of
Diurnal Rhythm in Refractive Error. Melanie
C. Campbell1, 2, K. Bunghardt1, M. L. Kisilak1, 2,
E. L. Irving2. 1Physics & Astronomy, University
of Waterloo, Waterloo, ON, Canada; 2School of
Optometry and Vision Science, University of
Waterloo, Waterloo, ON, Canada *CR
3605 — A0054 Macrophage Activation Pattern
in Human Myopic Choroidal Neovascular
Membranes. Khaled Nassar, E. El Far, J. Luke,
M. Luke, S. Grisanti, S. Grisanti. Ophthalmology,
Luebeck University, Luebeck, Schleswig-Holstein,
Germany
3606 — A0055 Eye Dimensions during
Lens Induced Myopia (LIM) and Recovery
in the Chick. Zheng Shao1, 2, K. Bunghardt1, M.
L. Kisilak1, 2, M. C. Campbell1, 2. 1Physics and
Astronomy, University of Waterloo, Waterloo, ON,
Canada; 2School of Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada
3607 — A0056 Phase-dependent effects of
brief periods of myopic defocus on the rhythms
in axial length and choroid thickness in
chicks. Debora L. Nickla, R. Zanzerkia, P. Thai, K.
Totonelly. Biosciences, New England College of
Optometry, Boston, MA
3608 — A0057 Predicting refractive error from
ocular biometrics using structural equation
modeling. Christopher A. Clark, A. E. Elsner, B. J.
Konynenbelt. School of Optometry, University of
Indiana, Bloomington, IN
254
Tuesday – Poters – 3609 – 3626
3609 — A0058 Quality of life of patients
suffering from pathological myopia: overview of
their social and emotional environment. David
Gaucher1, 2, C. Chartier3, M. Weber4, F. Malecaze5,
S. Y. Cohen6, E. H. Souied7, N. Leveziel8. 1NHC,
University Hospital, Strasbourg, France; 2Strasbourg
university, Strasbourg, France; 3Novartis
Pharma, Rueil Malmaison, France; 4Ophthamic
department, University hospital of Nantes,
Nantes, France; 5Toulouse University, Toulouse,
France; 6CIL, Paris, France; 7Paris Est University,
Creteil, France; 8Poitiers Université, Poitiers,
France *CR
3610 — A0059 Right eyes are longer than left
eyes: axial length findings from a large cataract
cohort with consistent refractive findings
from a large twin cohort. Omar A. Mahroo1, 2,
P. G. Hysi3, O. Kailani4, J. Thompson4, C. J.
Hammond1, 3. 1Ophthalmology, King’s College
London, London, United Kingdom; 2Physiology,
Development and Neuroscience, University of
Cambridge, Cambridge, United Kingdom; 3Twin
Research and Genetic Epidemiology, King’s
College London, London, United Kingdom;
4
West Kent Eye Centre, Princess Royal University
Hospital, London, United Kingdom
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Clinical/Epidemiologic Research / Visual
Psychophysics / Physiological Optics
375 Myopia - prevalence, risk factors,
and possible treatments
Moderators: Mina Torres and Stacy M. Meuer
3615 — A0064 Prevalence and characteristics
of myopic retinopathy in an adult Chinese
American population: The Chinese American
Eye Study. Rohit Varma1, S. M. Meuer2, R. Klein2,
S. Wu1. 1Ophthalmology & Visual Sciences, Illinois
Eye & Ear Infirmary, Chicago, IL; 2Ophthalmology
and Visual Sciences, University of Wisconsin at
Madison, Madison, WI
3616 — A0065 Retinal pathology in highly
myopic eyes: ZOC-BHVI High Myopia
Study. linxing chen1, B. A. Holden2, M.
He1. 1Zhongshan Ophthalmic Center, Guangzhou,
China;2Brien Holden Vision Institute, Sydney, ACT,
Australia
3617 — A0066 Frequency of retinal pathology
in high myopia. The MYST study. Corina
Brussee1, 2, G. H. Buitendijk1, 2, H. Springelkamp1, 2,
M. Snabel1, G. P. Luyten3, G. A. Van Rijn3, C.
J. Boon3, A. Geerards4, V. J. Verhoeven1, 2, C. C.
Klaver1, 2. 1Ophthalmology, Erasmus Medical
Center, Rotterdam, Netherlands; 2Epidemiology,
Erasmus Medical Center, Rotterdam,
Netherlands; 3Ophthalmology, Leiden University
Medical Center, Leiden, Netherlands; 4The
Rotterdam Eye Hospital, Rotterdam, Netherlands
3612 — A0061 Guinea pig optic nerve
head. Lisa A. Ostrin1, C. Wildsoet2. 1College of
Optometry, University of Houston, Houston, TX;
2
School of Optometry, University of California
Berkeley, Berkeley, CA
3618 — A0067 Projected generational increase
in myopic retinopathy in the United States. Noel
A. Brennan. R&D, Myopia Control Platform,
Johnson & Johnson Vision Care, Inc, Jacksonville,
FL *CR
3613 — A0062 Spectral-domain optical
coherence tomography imaging of the retinal
pigment epithelium in myopic choroidal
neovascularization. Laura Dell›Arti1, 2, D.
Vezzola1, G. Barteselli1, 3, C. Mapelli2, E. Benatti1, 2,
F. Viola1, 2, R. Ratiglia1, 2. 1University of Milan,
Milan, Italy; 2Ophthalmology, clinical sciences
and community health, Fondazione IRCCS Ca
Granda Ospedale Maggiore Policlinico, Milan,
Italy; 3Ophthalmology, Shiley Eye Center UCSD,
San Diego, CA
3619 — A0068 Canadian Burden Of Choroidal
Neovascularization Secondary To Pathologic
Myopia: Final Results. Nancy Zaour1, O. Heisel2,
P. Ma3. 1Novartis Pharmaceuticals Canada Inc,
Dorval, QC, Canada; 2Syreon Corporation,
Vancouver, BC, Canada; 3University of British
Columbia, Vancouver, BC, Canada *CR
3614 — A0063 Contribution of body
length on axial length during normal eye
development in C57BL/6J and 129S1/SvJ
wild-type mouse strains. Ranjay Chakraborty1, 2,
H. Park1, 2, C. C. Tan1, 2, M. Prunty1, 2, M. T.
Pardue2, 1. 1Ophthalmology, Emory University
School of Medicine, Atlanta, GA; 2Rehab R&D
Center of Excellence, Atlanta VA Medical Center,
Atlanta, GA
3620 — A0069 Optic Disc and Retinal
Changes in Highly Myopic Young Adolescent
Eyes. Victor Koh1, 2, C. Cheng1, C. S. Tan4, G. Nah2,
P. Zhao2, M. Tan3, A. Yang3, K. Ohno-Matsui5,
S. Saw6. 1Ophthalmology, National University
Health System, Singapore, Singapore; 2Singapore
Armed Forces Vision Performance Centre, Military
Medicine Institute, Singapore, Singapore; 3DSO
National Laboratories, Singapore, Singapore; 4Tan
Tock Seng Hospital, Singapore, Singapore; 5Tokyo
Medical and Dental University, Tokyo,
Japan; 6Department of Epidemiology and Public
Health, Yong Loo Lin School of Medicine, National
University of Singapore, Singapore, Singapore
3622 — A0071 Prevalence and Associated
Factors of Myopia in Primary School Students
in Chaoyang District of Beijing, China. Yueqiu
Gong1, H. Zhang1, Y. Y. Lv1, D. Wang1, T. Chen1,
S. H. Yang1, D. Y. Liu1, M. X. Kang1, X. H.
Guo2. 1Capital Institute of Pediatrics, Beijing,
China, Beijing, China; 2Chaoyang Center for
Disease Control and Prevention, Beijing, China
3623 — A0072 Ocular biometric distribution
and correlation with life style of the third and the
fourth grade elementary school children. Jinho
Jeong. Ophthalmology, Jeju national university
hospital, Jeju, Republic of Korea
3624 — A0073 Reference centile curve
as a predictor for high myopia in Chinese
children. Yanxian Chen1, J. Zhang1, W. Li2, I. G.
Morgan3, M. He1. 1Zhongshan Ophthalmic Center,
Guangzhou, China; 22. Brien Holden Vision
Institute, Sydney, NSW, Australia; 33. ARC Centre
of Excellence in Vision Science and Research
School of Biology, College of Medicine, Biology
and Environment, Australian National University,
Canberra, ACT, Australia
3625 — A0074 Provision of spectacles
improves academic performance of primary
school children in a randomized trial in
China. Nathan G. Congdon1, 2, X. Ma3, Z. Zhou1,
H. Yi4, X. Pang5, Y. Shi6, Q. Chen1, M. Meltzer1,
M. He1, S. Rozelle7. 1Preventive Ophthalmology,
Zhongshan Ophthalmic Center, Guangzhou,
China; 2ORBIS International, NYC, NY; 3UC
Davis, Davis, CA; 4Chinese Acad Science, Beijing,
China; 5Renmin University, Beijing, China; 6Sch. of
Economic Mgmt, Xian, China; 7Stanford University,
Palo Alto, CA f
3626 — A0075 Eye Shapes Measured by
MRI are Different in Different Age Groups of
Chinese School Children with Similar Refractive
States. Liqin Jiang1, X. Zhou1, B. Drobe1, D.
Troilo2. 1Wenzhou Medical University, Wenzhou,
Zhejiang, China; 2SUNY College of Optometry,
New York, NY
255
Tuesday Posters
3:45 pm – 5:30 pm
3611 — A0060 Replication analysis of myopiaassociated genes in Japanese cohort and in highly
myopic patients using genome-wide association
study. Munemitsu Yoshikawa1, K. Yamashiro1, M.
Miyake1, 2, M. Oishi1, Y. Kimura1, K. Kumagai1, Y.
Akagi-Kurashige1, 2, H. Nakanishi1, 2, N. Gotoh1, 2,
N. Yoshimura1. 1Department of Ophthalmology and
Visual Sciences, Kyoto University Graduate School
of Medicine, Kyoto, Japan; 2Center for Genomic
Medicine/Inserm U.852, Kyoto University Graduate
School of Medicine, Kyoto, Japan
3621 — A0070 Prevalence, Incidence And
Characteristics Of Patients With Choroidal
Neovascularization Secondary To Pathologic
Myopia In A Representative Canadian
Cohort. Megan Pickering1, L. Luciani2, N. Zaour1,
R. Petrella3, 4. 1Novartis Pharmaceuticals Canada
Inc, Dorval, QC, Canada; 2University of Montreal,
Montreal, QC, Canada; 3Indivisual health outcomes
Inc, London, ON, Canada; 4Lawson Health
Research Institute, London, ON, Canada *CR
3627 — A0076 Factors underlying large
differences in myopia prevalence among primary
school children in adjoining provinces of western
China. Zhongqiang Zhou1, X. Ma2, H. Yi3, X.
Pang4, Y. Shi5, M. Meltzer1, M. He1, S. Rozelle6,
I. G. Morgan1, N. G. Congdon1, 7. 1Division
of Preventive Ophthalmology, Zhongshan
Ophthalmic Center, Sun Yat-sen University,
GUANGZHOU, China; 2University of California
Davis, Davis, CA; 3Chinese Academy of Science,
Beijing, China; 4Renmin University of China,
Beijing, China; 5Northwest University, Xian,
China; 6Stanford University, Palo Alto, CA; 7ORBIS
International, NYC, NY f
Tuesday Posters
3:45 pm – 5:30 pm
3628 — A0077 Prevalence of myopia in
an adolescent British cohort and cognitive
associations during childhood. Katie M.
Williams1, 2, P. G. Hysi2, R. Plomin3, C. J.
Hammond1, 2. 1Department of Ophthalmology,
King’s College London, London, United
Kingdom; 2Department of Twin Research and
Genetic Epidemiology, King’s College London,
London, United Kingdom; 3MRC Social, Genetic
and Developmental Psychiatry Centre, King’s
3629 — A0078 An Annual Rate of Myopic
Progression Model for Asian children. Padmaja
Sankaridurg1, 2, B. A. Holden1, 3, L. A. Donovan1, 2,
C. To4, W. Chua5, L. Li6, X. Chen6.1Optometry,
Brien Holden Vision Institute, Sydney, NSW,
Australia; 2Vision Cooperative Research Centre,
Sydney, NSW, Australia; 3School of Optometry
and Vision Science, University of New South
Wales, Sydney, NSW, Australia; 4School of
Optometry, Hong Kong Polytechnic University,
Hong Kong, Hong Kong; 5Park Way Eye Centre@
Mount Elizabeth, Singapore, Singapore;6State
Key Laboratory of Ophthalmology, Zhongshan
Ophthalmic Centre, Guangzhou, China *CR, f
3630 — A0079 Refractive error and retinal
complications in a large multicentric cohort
of French individuals. Matamoros Emilie1,
F. Pelen2, Y. Lefevre2, P. Pouts2, Y. Bentaleb2,
M. Weber3, J. Korobelnik4, E. H. Souied5, N.
Leveziel6. 1Department of Ophthalmology,
Poitiers, France; 2Ophtapointvision, Paris,
France; 3Ophthalmology, Nantes University
Hospital, Nantes, France; 4Ophthalmology,
Bordeaux University Hospital, Bordeaux,
France; 5Ophthalmology, Creteil Eye University,
Creteil, France; 6Ophthalmology, University
Hospital of poitiers, Poitiers, France
3632 — A0081 Is myopia more common
in Asians? A systematic review and metaanalysis. Seang-Mei Saw1, 2, C. Pan1, 2, M.
Dirani3, C. Cheng4, 1, T. Y. Wong2, 1. 1Saw Swee
Hock School of Public Health, National Univ
of Singapore, Singapore, Singapore; 2Singapore
Eye Research Institute, Singapore,
Singapore; 3Melbourne University, Melbourne, VIC,
Australia;4Ophthalmology, National University of
3633 — A0082 The Prevalence of Uncorrected
Refractive Error and Unmet Refractive Need
in Chinese Americans: The Chinese American
Eye Study (CHES). Charlotte E. Joslin1, 2, C. Hsu1,
S. Wu1, X. Jiang1, M. Torres1, R. Varma1. 1Illinois
Eye and Ear Infirmary, Ophthalmology and Visual
Science, University of Illinois at Chicago, Chicago,
IL; 2Epidemiology and Biostatistics, Univeristy of
Illinois at Chicago, Chicago, IL
3634 — A0083 Choroidal thickness profiles in
myopic eyes of young adults in the Correction of
Myopia Evaluation Trial cohort. Elise N. Harb1,
L. Hyman2, J. E. Gwiazda1, W. Marsh-Tootle3, Q.
Zhang2, W. Hou2, T. T. Norton5, K. Dirkes4, L. M.
Zangwill4. 1New England College of Optometry,
Boston, MA; 2Preventive Medicine, Stony
Brook University, Stony Brook, NY; 3School of
Optometry, University of Alabama at Birmingham,
Birmingham, AL; 4Hamilton Glaucoma Center,
Dept. of Ophthalmology, University of California at
San Diego, San Diego, CA; 5Department of Vision
Sciences, University of Alabama at Birmingham,
Birmingham, AL *CR, f
3635 — A0084 Vision Impairment in Highly
Myopic Eyes: the ZOC-BHVI High Myopia
Study. Brien A. Holden1, 3, M. He2, M. Jong1,
W. Li4, S. Resnikoff1, I. G. Morgan5, E. L.
Smith6. 1Research, Brien Holden Vision Institute,
Sydney, NSW, Australia; 2Ophthalmology,
Zhongshan Opthalmic Centre, Guangzhou,
China; 3School of Optometry and Vision Science,
University of New South Wales, Sydney, NSW,
Australia; 4Research, Brien Holden Vision Institute
(China), Guangzhou, China; 5ARC Centre of
Excellence in Vision Science and Visual Sciences
Group, Research School of Biology, College of
Medicine, Australian National University, Canberra,
ACT, Australia; 6College of Optometry, University
of Houston, Houston, TX
3636 — A0085 The rate of myopia
progression in children who become highly
myopic. Monica Jong1, M. He2, B. A. Holden1, 3,
W. Li4, P. Sankaridurg1, X. Chen2, T. Navadiluth1,
E. L. Smith5, I. G. Morgan6, J. Ge2. 1Research,
Brien Holden Vision Institute, Sydney, NSW,
Australia; 2Ophthalmology, Zhongshan Opthalmic
Centre, Guangzhou, China; 3School of Optometry
and Vision Science, University of New South
Wales, Sydney, NSW, Australia; 4Research, Brien
Holden Vision Institute (China), Guangzhou,
China; 5College of Optometry, University of
Houston, Houston, TX; 6ARC Centre of Excellence
in Vision Science and Visual Sciences Group,
Research School of Biology, College of Medicine,
Australian National University, Canberra, ACT,
Australia
3637 — A0086 Comparison of Three Power
Levels of A Novel Soft Contact Lens Optical
Design to Reduce Suspected Risk Factors for
the Progression of Juvenile Onset Myopia.
Sally M. Dillehay1, J. Woods2, P. Situ2, S. Guthrie2,
R. E. Payor1, R. A. Griffin1, M. Tyson1, L. W.
Jones2. 1Visioneering Technologies Inc, Alpharetta,
GA; 2School of Optometry, University of Waterloo,
Waterloo, ON, Canada *CR
3638 — A0087 Feasibility Testing of a Novel
Soft Contact Lens Optical Design to Reduce
Suspected Risk Factors for the Progression of
Juvenile Onset Myopia. Rick E. Payor1, J. Woods2,
D. Fonn2, P. Situ2, S. M. Dillehay1, R. A. Griffin1,
M. Tyson1, L. W. Jones2. 1Visioneering Technologies
Inc., Alpharetta, GA; 2School of Optometry,
University of Waterloo, Waterloo, ON, Canada *CR
3639 — A0088 Comparison of Self-service
Refractor with Auto-refraction and Subjective
Refraction. Yi Zhen, J. Shen, J. Hao. Beijing
Tongren Eye Center, Beijing, China
3640 — A0089 Prevalence of astigmatism in
school-aged children: a multi-country refractive
error study in children. Lili Wang1, M. He1, L.
Ellwein2. 1State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Center, Guangzhou,
China; 2National Eye Institute, National Institute of
Health, Bethesda, MD
3641 — A0090 Estimation of Time Spent
Outdoors Using Personal UV and Visible Light
Dosimetry. Donald O. Mutti, S. P. Mulvihill.
College of Optometry, Ohio State University,
Columbus, OH
3642 — A0091 Possible cause of monozygotic
twins discordant in refraction: nearwork,
outdoor activity and stochastic variation. Xiaohu
Ding1, I. G. Morgan2, M. He1.1Zhongshan
Ophthalmic Center, Guangzhou, China; 2ARC
Centre of Excellence in Vision Science and
Research School of Biology, Canberra, ACT,
Australia
3631 — A0080 Prevalence of Myopic
Refractive Error in Adult Chinese-Americans:
The Chinese-American Eye Study. Shuang
Wu1, C. Hsu1, M. Torres1, R. McKean-Cowdin2,
S. P. Azen2, R. Varma1. 1University of Illinois at
Chicago, Los Angeles, CA; 2University of Southern
3643 — A0092 Two patterns of ciliary muscle
growth in myopia. Melissa D. Bailey1, C. Kao2,
N. Satiani1, L. T. Sinnott1. 1Optometry, Ohio
State University, Columbus, OH;2Mathematics,
Claremont McKenna College, Claremont, CA *CR
256
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Cornea
376 Dry Eye Disease #2
Moderators: Benjamin D. Sullivan and
Sandeep Jain
3644 — A0158 Age-Related Changes In
Morphological And Functional Characteristics
Of Corneal Nerves And Wound Healing Rate
Of Guinea Pigs. M Carmen Acosta1, K. Mizerska1,
C. Luna1, S. Quirce1, D. Berbel1, J. Sesma1, N.
Cuenca2, C. Belmonte1, 3, J. Gallar1. 1Instituto de
Neurociencias, Universidad Miguel HernandezCSIC, San Juan, Spain; 2Departamento de
Fisiología, Genética y Microbiología, Universidad
de Alicante, San Vicente del Raspeig, Spain;
3
Instituto Oftalmológico Fernández-Vega,
Fundación de Investigación Oftalmológica, Oviedo,
Spain
3645 — A0159 In vivo Functional
Characterization of Trigeminal Neurons
Innervating the Eye and Periocular Tissues.
Juana Gallar, B. Santiago, M. Acosta, C. Belmonte.
Instituto de Neurociencias, Universidad Miguel
Hernandez-CSIC, San Juan de Alicante, Spain
3647 — A0161 Blinking and the Sensory
Response to Increasing Air Stimulation at the
Ocular Surface. Ziwei Wu1, C. G. Begley1, P. Situ1,
T. L. Simpson2. 1Optometry, Indiana University,
Bloomington, IN; 2Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada
3648 — A0162 Effects of Corneal Nerve
Density on the Response to Treatment in Dry
Eye Disease. Ahmad Kheirkhah, T. H. Dohlman,
F. Amparo, M. A. Arnoldner, Y. Qazi, A. Jamali, P.
Hamrah, R. Dana. Ophthalmology, Massachusetts
Eye and Ear Infirmary, Boston, MA *CR, f
3649 — A0163 Age-Related Corneal Sensitivity
assessed with a modified BHVI-Belmonte
Aesthesiometer: a preliminary study. Alex
Gonzalez1, K. Ehrmann2, C. Rowaan1, W. Lee1, M.
C. Aguilar1, A. L. McClellan3, N. M. Shalabi1, 3,
A. Galor1, 3, J. A. Parel1, 2. 1Ophthalmic Biophysics
Center, Bascom Palmer Eye Institute, University
of Miami School of Medicine, Miami, FL; 2Vision
Cooperative Research Centre, Brien Holden Vision
Institute, UNSW, Sydney, NSW, Australia; 3VA
Medical Center, Miami, FL
3651 — A0165 Effect of Chondrocyte-derived
Extracellular Matrix on Dry Eye Mouse Model.
Chae Eun Kim1, J. Lee1, J. Yang1, 2. 1Ocular
Neovascular Disease Research C, Inje University
Busan Paik Hospital, Busan, Republic of Korea;
2
Department of Ophthalmology, Inje University
College of Medicine, Busan, Republic of Korea
3652 — A0166 Effectiveness of Topical
AICA-Ribonucleotide in a Mouse Model of
Experimental Dry Eye. Mi Sun Sung1, Z. Li1, J.
Yang1, J. Choi1, I. You2, K. Yoon1.1Ophthalmology,
Chonnam National University Medical
School and Hospital, Gwangju, Republic of
Korea; 2Ophthalmology, Chonbuk National
University Medical School and Hospital, Jeonju,
Republic of Korea
3653 — A0167 Regulatory T cell mediated
suppression of dendritic cells in a mouse model
of dry eye. Katherine S. Held1, C. S. Schaumburg1,
J. Gao1, J. Nieves1, E. Oh1, L. A. Wheeler1, V. L.
Calder2, J. Y. Niederkorn3, S. C. Pflugfelder4, M. E.
Stern1. 1Inflammation R&D, Allergan Inc, Irvine,
CA; 2Genetics, University College London, London,
United Kingdom;3Ophthalmology, Univeristy of
Texas SW-Med Center, Dallas, TX; 4Ophthamology,
Baylor College of Medicine, Houston, TX *CR
3654 — A0168 An in vivo study of antiinflammatory effect of Quercetin and
Resveratrol polyphenols in a desiccating stress
mouse model of dry eye. Antonio AbengózarVela1, 2, C. S. Schaumburg4, M. E. Stern4, V.
L. Calder3, M. Calonge1, 2, A. Enriquez-DeSalamanca1, 2, M. J. Gonzalez1, 2. 1Ocular Surface
Group, IOBA - University of Valladolid, Valladolid,
Spain;2Biomedical Research Networking Center in
Bioengineering, Biomaterials and Nanomedicine
(CIBER-BBN), Valladolid, Spain; 3Department
of Ocular Biology and Therapeutics, UCL
Kingdom; 4Biological Sciences, Allergan Inc.,
Irvine, CA *CR
3655 — A0169 Tear function and ocular
surface abnormalities under environmental
stress conditions in the Nrf2(-/-) Mouse. Takashi
Kojima1, 3, T. Nagata1, S. Nakamura1, M. Dogru2, 1,
K. Tsubota1. 1Ophthalmology, Keio Univ School of
Medicine, Tokyo, Japan; 2Ophthalmology, Tokyo
Dental College, Ichikawa, Japan; 3Ophthalmology,
Gfu Red Cross Hospital, Gifu, Japan
3656 — A0170 Effects of Mesenchymal Stem/
Stromal Cells in T cell-mediated Dry Eye Model
in Mice. Min Joung Lee1, 2, A. Ko4, J. Ko4, M.
Kim1, 3, W. Wee1, 3, S. Khwarg1, 3, H. Choung1, 5,
J. Oh1, 3. 1Ophthalmology, College of Medicine,
Seoul National University, Seoul, Republic of
Korea; 2Ophthalmology, Hallym University
Sacred Heart Hospital, Anyang, Republic of
Korea; 3Ophthalmology, Seoul National University
Hospital, Seoul, Republic of Korea; 4Laboratory of
Ocular Regenerative Medicine and Immunology,
Biomedical Research Institute, Seoul, Republic of
Korea; 5Ophthalmology, Seoul National University
Boramae Hospital, Seoul, Republic of Korea
3657 — A0171 Impact of the Host Microbiota
on the Development of Murine Desiccating
Stress-Induced Dry Eye Disease. Chris S.
Schaumburg1, K. S. Held1, A. M. Ratanapinta1,
M. Paul1, L. A. Wheeler1, M. Calonge2, J.
Y. Niederkorn3, S. C. Pflugfelder4, M. E.
Stern1. 1Biological Sciences, Allergan, Irvine,
CA; 2Institute for Applied OphthalmoBiology
(IOBA), University of Valladolid, Valladolid,
Spain; 3Ophthalmology, UT Southwestern Medical
Center, Dallas, TX; 4Ocular Surface Center, Cullen
Eye Institute, Ophthalmology, Baylor College of
Medicine, Houston, TX *CR
3658 — A0172 Conjunctival immunological
tolerance in a murine evaporative dry eye
model. Jeremias G. Galletti1, M. Guzmán1, F.
Sabbione1, M. Gabelloni1, S. Vanzulli1, P. A.
Chiaradía2, J. F. Casiraghi2, A. S. Trevani1, M. N.
Giordano1. 1Immunology, Institute of Experimental
Medicine, National Academy of Medicine, Buenos
Aires, Argentina; 2Ophthalmology, Hospital de
Clínicas, University of Buenos Aires, Buenos Aires,
Argentina
3659 — A0173 The Potential of Quercetin for
Dry Eye Diseases. Takaaki Inaba1, J. Shimazaki2,
Y. Tanaka1, K. Tsubota1. 1Ophthalmology, Keio
University, Shinjyuku-ku, Japan;2Ophthalmology,
Tokyo Dental College, ichikawa, Japan
3660 — A0174 Effects of Environmental
Enrichment on Tear Secretion in Mice. Kokoro
Sano1, M. Kawashima1, A. Ito1, I. Toshihiro1,
R. Hisamura1, S. Nakamura1, M. Watanabe2, K.
Tsubota1. 1Keio University School of Medicine,
Tokyo, Japan; 2Health Science Laboratory, Keio
Research Institute at Shonan-Fujisawa Campus,
Keio University, Tokyo, Japan
3661 — A0175 CCR7 is critical in the induction
and maintenance of Th17 immunity in dry eye
disease. Shilpa Kodati1, 2, Y. Chen1, T. H. Dohlman1,
S. K. Chauhan1, D. R. Saban1, 3, R. Dana1. 1Schepens
Eye Research Institute and Massachusetts Eye
and Ear Infirmary, Harvard Medical School,
Boston, MA; 2Ophthalmology, UPMC Eye Center,
Pittsburgh, PA;3Ophthalmology, Duke University,
Durham, NC *CR
257
Tuesday Posters
3:45 pm – 5:30 pm
3646 — A0160 Dry-eye-like Symptoms without
Dessicated Signs Implies Corneal Neuropathy:
An In Vivo Confocal Microscopy Study. Yimin
Li, J. Xu, J. Hong, Q. Le. Eye & ENT Hospital,
Fudan University, Shanghai, China
3650 — A0164 Loss of Muc16 induces
activates Stat3 signal and IL-6 expression in
conjunctiva and secondarily affects corneal
wound healing in mice. Shizuya Saika1, K. Shiai1,
Y. Okada1, M. Miyajima2, R. R. Behringer3, 4, O.
Yamanaka1. 1Ophthalmology, Wakayama Medical
University, Wakayama, Japan; 2The Laboratory
Animal Center, Wakayama Medical University,
Wakayama, Japan; 3Program in Genes and
Development, The University of Texas Graduate
School of Biomedical Sciences, Houston,
TX; 4Genetics, The University of Texas Graduate
School of Biomedical Sciences, Houston, TX
3662 — A0176 Orally Administered
Lactoferrin Prevents Stress Induced Dry
Eye Disease In Mice. Samuel Connell1, 2, M.
Kawashima1, I. Toshihiro1, K. Sano1, A. Ito1, K. Jin1,
S. Nakamura1, R. Hisamura1, K. Tsubota1. 1Keio
University, Shinjuku-ku, Japan; 2Medical and
Veterinary Science, University of Bristol, Bristol,
United Kingdom *CR
3663 — A0177 Optimization of an
Inflammation-Based Murine Model of Dry
Eye. Laura Belen, K. Violette, G. W. Ousler, A.
Whitlock. Pre-clinical, Ora Inc, Andover, MA *CR
Tuesday Posters
3:45 pm – 5:30 pm
3664 — A0178 Increased Substance P
Expression in the Ocular Surface in Murine
Dry Eye Disease. Sang-Mok Lee1, 2, Z. Sadrai1,
H. Lee1, 3, W. Stevenson1, Y. Chen1, J. Hua1, K.
Katikireddy1, T. H. Dohlman1, S. K. Chauhan1, R.
Dana1. 1Dana lab, Schepens Eye Research Institute,
Medical School, Boston, MA;2Ophthalmology,
Hallym University Sacred Heart Hospital, Anyang,
Republic of Korea; 3Ophthalmology and Visual
Science, The Catholic University of Korea School
of Medicine, Seoul, Republic of Korea
3665 — A0179 Reduced Number And Altered
Functional Activity Of Mouse Corneal Cold
Sensory Nerve Fibers With Age Develop In
Parallel With Decreased Basal Tearing. Omar
González González1, 2, I. Alcalde1, 2, A. ÍñigoPortugués1, 2, J. Gallar3, J. Merayo-Lloves1, 2,
C. Belmonte1, 3. 1Fundacion Investigacion
Oftalmologica, Oviedo, Spain; 2Universidad de
Oviedo, Oviedo, Spain; 3Instituto de Neurociencias
Universidad Miguel Hernandez-CSIC, San Juan de
Alicante, Spain
3666 — A0180 Autoimmune regulator (Aire)
gene deficient mice, a model of autoimmunemediated, aqueous-deficient dry eye, exhibit
functional alteration of a recently demonstrated,
special type of corneal nerves involved in basal
tearing, referred to as the dry-sensitive corneal
afferents. Harumitsu Hirata1, T. Vijmasi2, M. I.
Rosenblatt1, N. A. McNamara2. 1Ophthalmology,
Weill Cornell Medical College, New York, NY; 2FI
Proctor Foundation, University of California at San
Francisco, San Francisco, CA
3667 — A0181 Secretory Group Two A
Phospholipase (sPLA2-IIa) Expression and
Function in Ocular Surface of Dry Eye Disease
(DED) Mice. Yi Wei, P. Li, Z. Du, D. Chen, S. P.
Epstein, P. A. Asbell. Ophthalmology, Icahn School
of Medicine at Mount Sinai, New York, NY
3668 — A0182 In vivo rabbit tolerability
and safety of a Manuka honey-based eye
preparation for blepharitis. Jennifer P. Craig1,
I. D. Rupenthal1, A. Seyfoddin2, 1, A. Chen1, 3,
G. Watters1. 1Ophthalmology, University of
Auckland, Auckland, New Zealand; 2School of
Pharmacy, University of Auckland, Auckland, New
Zealand; 3Optometry and Vision Science, University
of Auckland, Auckland, New Zealand *CR
3669 — A0183 Effect of Three Tear
Supplements on Signs, Symptoms and ProInflammatory Markers in Subjects with Dry
Eye Disease. Eilidh Martin1, 2, S. Hagan1, 2,
K. Oliver1, I. Pearce1, A. Tomlinson1. 1Vision
Sciences, Glasgow Caledonian University,
Glasgow, United Kingdom; 2Biological Sciences,
Glasgow Caledonian University, Glasgow, United
Kingdom *CR
3670 — A0184 Effect of Lachrymal Substitutes
on Tear Film Thickness in Patients with
Moderate Dry Eye Syndrome. Doreen Schmidl1, 2,
K. J. Napora1, 2, R. M. Werkmeister2, P. Rosner1,
G. Garhofer1, L. Schmetterer1, 2. 1Department of
Clinical Pharmacology, Medical University of
Vienna, Vienna, Austria; 2Center for Medical
Physics and Biomedical Engineering, Medical
University of Vienna, Vienna, Austria f
3671 — A0185 Plasma Rich in Growth Factors
(PRGF) compared with Autologous Serum for
Dry Eye Treatment. Edna Lucia Valdez Payan,
O. Fernandez, R. Velasco, O. Baca, A. Babayan,
C. Pacheco Del Valle, E. D. Alegria, A. RoblesContreras. Hospital de la Luz, Mexico, Mexico f
3672 — A0186 Reduced Rescue Artificial Tear
Use in Subjects Using a Topical Interleukin-1
(IL-1) Receptor-1 (R1) Blocker for Ocular
Treatment of Dry Eye Disease (DED).Michael H.
Goldstein1, 2, G. Zarbis-Papastoitsis2, K. Golden2, C.
Wheeler2, J. Kovalchin2, J. Agahigian2, K. Tubridy2,
A. Celniker2, E. S. Furfine2. 1Ophthalmology,
New England Eye Center, Boston, MA; 2Eleven
Biotherapeutics, Cambridge, MA *CR, f
3673 — A0187 SYL1001, a new treatment
based on RNAi for the treatment of ocular
pain. Veronica Ruz1, V. Gonzalez1, C. MartinezGarcia2, C. Pañeda1, A. Jiménez1. 1Sylentis, Madrid,
Spain; 2Universidad de Valladolid, Valladolid,
Spain *CR, f
3674 — A0188 Treatment Response In A
Clinical Trial For Dry Eye Varies With Entering
Level Of Signs And Symptoms. Peter A. Simmons,
H. Liu, J. G. Vehige, C. Carlisle, R. Chen, G. Shi.
Clinical Research, Allergan, Inc, Irvine, CA *CR, f
3675 — A0189 GML inhibits lipase production
by ocular isolates. Neeta Khandekar1, J.
Flanagan1, 2, K. Watanabe1, 3, R. S. Bandara1, A.
Ariyavidana1, B. A. Holden1, 2, E. B. Papas1, 2,
H. Zhu1, 2. 1Brien Holden Vision Institute,
Sydney, NSW, Australia; 2School of Optometry
and Vision Sciences, UNSW, Sydney, NSW,
Australia; 3Department of Ophthalmology, Kinki
University Faculty of Medicine, Osaka, Japan
3676 — A0190 Lipase production by
ocular bacteria. Hua Zhu1, 2, K. Watanabe3, J.
Flanagan1, 2, R. S. Bandara1, B. A. Holden1, 2, E.
Papas1, 2. 1Brien Holden Vision Institute, Sydney,
NSW, Australia; 2Schoold of Optometry and Vision
Science, University of New South Wales, Sydney,
NSW, Australia; 3Department of Ophthalmology,
Kinki University Faculty of Medicine, Osaka, Japan
3677 — A0191 Veterinary Clinical
Investigations: Use Of Heterologous
Mesenchymal Stem Cells In Dogs With
Keratoconjunctivitis Sicca. Maura K. Bittencourt1,
M. A. Barros2, K. Evangelho3, J. C. Vasconcellos1,
J. P. Martins4, M. D. Bittencourt5, C. V.
Wenceslau2, B. P. Morais6, I. Kerkis4. 1Department
of Ophthalmology, Universidade Estadual de
Campinas (UNICAMP), Campinas, Brazil;
2
Universidade Federal de São Paulo, São Paulo,
Brazil; 3Universidad Nacional de Rio Cuarto,
Rio Cuarto, Argentina; 4Instituto Butantan, São
Paulo, Brazil; 5Department of Ophthalmology,
Hospital Beneficência Portuguesa, São Paulo,
Brazil; 6Universidade de São Paulo (USP), São
Paulo, Brazil *CR
3678 — A0192 Oral administration of Maqui
berry (Aristotelia chilensis) extract restores
tear secretion capacity in rat blink-suppressed
dry eye model by modulating lacrimal gland
function. Shigeru Nakamura1, J. Tanaka2,
R. Hisamura1, I. Toshihiro1, H. Shimoda2, K.
Tsubota1. 1Ophtalmology, Keio University, Tokyo,
Japan; 2Research and Development, Oryza Oil &
Fat Chemical, Ichinomiya, Japan
3679 — A0193 Correlation between mRNA
and protein expression profiles of HLA-DR
in Conjunctival Impression Cytology using a
new device for collecting epithelial cells.Karima
KESSAL1, 3, L. Riancho1, 5, G. Rabut2, 3, H. Liang2, 3,
C. Boucher1, 5, S. Melik-Parsadaniantz1, 6, C.
Baudouin2, 3, F. Baudouin1, 4. 1Institut de la vision,
UPMC UMR S968, Paris, France; 2Ophtalmologie
III, CHNO XV-XX, Paris, France; 3Centre
Hospitalier National d’Ophtalmologie des
Quinze-Vingts, INSERM-DHOS CIC 503, Paris,
France; 4Faculté des Sciences Pharmaceutiques et
Biologiques, Université Paris Descartes, Sorbonne,
Paris, France; 5UPMC U968, INSERM, Paris,
France; 6UMR_7210, CNRS, Paris, France *CR
3680 — A0194 Differential Availability of
Active Lacritin and Cell Targeting Machinery
in Normal vs Aqueous Deficient Tears as
Insight into Cause. Gordon Laurie1, 2, N.
Wang1, R. L. McKown3, D. S. Ryan4, R. K. Sia4,
L. Peppers4. 1Cell Biology, Univ. of Virginia,
Charlottesville, VA; 2Ophthalmology, University of
Virginia, Charlottesville, VA; 3Integrated Science
and Technology, James Madison University,
Harrisonburg, VA; 4Warfighter Refractive Surgery
and Research Center at Fort Belvoir, Fort Belvoir,
VA *CR
3681 — A0195 Verification and validation of
a diurnal blink tracking device and pilot study
assessing responsiveness to CAESM exposure. John
D. Rodriguez1, E. Angjeli1, C. Heckley1, K. J. Lane1,
G. W. Ousler2. 1R & D, Ora Institute, Andover,
MA; 2Ora, Inc, Andover, MA *CR
258
3682 — A0196 Tear Cytokines in Non-Dry
Eye and Dry Eye Participants After Exposure
to a Low Humidity Environmental Exposure
Chamber. Lakshman N. Subbaraman1, D.
J. McCanna1, H. I. Lorentz2, F. Soong2, A.
Salapatek2, L. W. Jones1. 1CCLR, School of
Optometry, University of Waterloo, Waterloo, ON,
Canada; 2Inflamax Research Inc, Mississauga, ON,
Canada *CR
3683 — A0197 Correlations between nonstimulated tear levels and conjunctival gene
expression of MAPK pathway-associated
biomarkers in aqueous-deficient dry eye and
control patients. Roderick J. Fullard, N. M.
Guyette, M. K. Tran, J. L. Bradley. Vision Sciences,
Univ of Alabama Birmingham, Birmingham, AL
3684 — A0198 Topical immunomodulator
use in the treatment of primary or secondary
Sjogren dry eye disease patients. Rossen
Hazarbassanov, C. Yamasato, D. Miura, J. Barros,
J. A. Gomes. Department of Ophthalmology and
Visual Sciences, Paulista School of Medicine, Sao
Paulo Hospital, Federal University of Sao Paulo,
Sao Paulo, Brazil f
3685 — A0199 Neutrophil Extracellular
Traps accumulate on ocular surface of Dry Eye
Disease patients: Potential for a new therapeutic
strategy using DNase I eye drops. Yair Ivanir,
S. Tibrewal, J. Sarkar, E. Kim, S. H. Jassim, S.
Sonawane, Y. Byun, R. Wahood, L. Schneider, S.
Jain. Corneal Neurobiology Laboratory, Department
of Illinois at Chicago, College of Medicine,
Chicago, IL
3687 — A0201 The brain-derived neurotrophic
factor rs6265 (Val66Met) polymorphism and dry
eye disease: Potential association with stressrelated disorders (depression/anxiety). Joelle
Hallak1, X. Gao2, S. Jain1. 1Corneal Neurobiology
laboratory, Department of Ophthalmology & Visual
Sciences, Univ Illinois Chicago, IEEI, Chicago,
IL;2Quantitative Ocular Genomics Laboratory,
Ophthalmology and Visual Sciences, Univ Illinois
Chicago, IEEI, Chicago, IL
3688 — A0202 Safety and Efficacy of Topical
1% docosahexaenoic acid (DHA) and 1%
alpha-linoleic acid (ALA) in a Canine Model.
Mausam R. Damani1, S. Iwabe2, G. D. Aguirre2, K.
Carlisle2, M. Pistilli1, V. Y. Bunya1. 1Department
of Ophthalmology, University of Pennsylvania,
Philadelphia, PA; 2Department of Veterinary
Medicine, University of Pennsylvania,
Philadelphia, PA
3690 — A0204 Objective Evaluation of Ocular
Surface Lubricants in Dry Eye Patients using
Thermal Imaging. Ranjini Kottaiyan1, H. B.
Hindman1, G. Yoon1, 2, S. Davio4, J. Zavislan2, 3, J.
Aquavella1. 1Flaum Eye Institute, University of
Rochester, Rochester, NY; 2The Institute of Optics,
University of Rochester, Rochester, NY; 3Center for
Visual Science, University of Rochester, Rochester,
NY; 4Bausch & Lomb, Rochester, NY f
3691 — A0205 Validation of a method for
determination of cyclosporine in rabbit tissues
in a pharmacokinetic study. Hai Tang. shenyang
sinqi, Shenyang, China
3692 — A0206 Safety evaluation of ocular
drug delivery formulation: an in vivo
approach. Vasudha Gupta1, H. I. Lorentz2, B. B.
Muirhead3, H. Sheardown2, 3. 1Ophthalmology,
McMaster University, Hamilton, ON, Canada;
2
Chemical Engineering, McMaster University,
Hamilton, ON, Canada; 3Biomedical Engineering,
McMaster University, Hamilton, ON, Canada
3693 — A0207 Ocular Pharmacokinetics of
P-321, a Novel Long-Acting Epithelial Sodium
Channel Blocker. John H. Ansede1, W. Thelin1, R.
C. Boucher4, M. Johnson1, P. Terse3, K. Warren2, J.
L. Boyer1. 1Parion Sciences, Durham, NC; 2Covance
Laboratories, Madison, WI; 3National Institute
of Health, Bethesda, MD; 4University of North
Carolina, Chapel Hill, NC *CR
3694 — A0208 Effectiveness of an eyelid
thermal pulsation procedure to treat
recalcitrant dry eye symptoms after refractive
surgery. Craig Schallhorn1, S. C. Schallhorn2, J. M.
Schallhorn2. 1University of California, San Diego,
San Diego, CA; 2UCSF, San Francisco, CA *CR
3695 — A0209 Effects of a dual polymer
artificial tear solution on prolonged protection
and recovery in an in-vitro Human corneal
epithelial cell model. Rekha Rangarajan, B.
Kraybill, H. A. Ketelson. Alcon Laboratories, Inc.,
Fort Worth, TX *CR
3696 — A0210 Intravitreal Dry Eye Study.
Vishwanath Srinagesh, D. Ellenberg, P. H. Scharper,
J. Etter. Krieger Eye Institute, Baltimore, MD
3697 — A0211 The Effect of Rebamipide to
the Human Conjunctival Epithelium. Yoshiyuki
Satake, K. Higa, M. Dogru, H. Mitamura, N.
Toriyama, J. Shimazaki. Ophthalmology, Tokyo
Dental College, Ichikawa, Japan *CR
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Cornea
377 Corneal biomechanics and
Keratoprosthesis
Moderator: Ahmed Elsheikh
3699 — A0213 Corneal profile on-axis
polynomial curve fitting in 2.2-mm incision
for phacoemulsification. Jaime Tejedor1, 2, F. J.
Gutiérrez-Carmona1. 1Ophthalmology, Hospital
Ramon y Cajal, Madrid, Spain; 2Neuroscience,
Universidad Autónoma de Madrid, Madrid, Spain
3700 — A0214 Finite element modeling for
the dynamic biomechanical characterization of
the in-vivo cornea. Sabine Kling1, 2, N. Bekesi2,
C. Dorronsoro2, S. Marcos2.1Opthalmologie,
Hôpitaux Universitaires de Genève, Genève,
Switzerland; 2Consejo Superior de Investigaciones
Cientificas, Instituto de Optica, Madrid, Spain *CR
3701 — A0215 Estimated corneal elastic
moduli from inverse finite element analysis of
corneal deformation in vivo. Abhijit Sinha Roy,
R. Shetty. Ophthalmology, Narayana Nethralaya,
Bangalore, India *CR
3702 — A0216 Intrastromal application of
riboflavin for corneal crosslinking. Theo G.
Seiler1, 2, I. Fischinger1, G. Schmidinger1, T. G.
Seiler1. 1IROC AG, Zürich, Switzerland;2University
of Zürich, Zürich, Switzerland *CR
3703 — A0217 Optimizing Brillouin
spectroscopy for in vivo biomechanical
assessment of the eye. Stephan Reiss1, 2, M.
Hovakimyan2, H. Stolz1, R. F. Guthoff2, O.
Stachs2.1Institute of Physics, University of Rostock,
Rostock, Germany; 2Department of Ophthalmology,
University of Rostock, Rostock, Germany
3704 — A0218 Spatial Mapping of Corneal
Biomechanical Properties with Optical
Coherence Elastography after UV Cross-linking
in the Rabbit. Srilatha Vantipalli1, J. Li2, M. Singh2,
K. Larin2, M. D. Twa1. 1College of Optometry,
University of Houston, Houston, TX; 2Department
of Biomedical Engineering, University of Houston,
Houston, TX
3705 — A0219 Differentiation of forme
fruste keratoconus from normal cornea
using parameters of corneal tomography,
aberration, and biomechanics. Ryotaro Ueki1, 2,
N. Maeda2, M. Fuchihata2, S. Koh2, T. Kitaoka1,
K. Nishida2. 1Nagasaki Univ School of Medicine,
Nagasaki-Shi, Japan; 2Osaka Univ Graduate Sch of
Med, Suita-Shi, Japan *CR
3698 — A0212 Disabling Single Use
Ophthalmic Medical Devices Sterilized with
Gamma Radiation. Jeffery Rosino, J. Hutchinson,
S. Grenon. TearScience, Inc., Morrisville, NC*CR
259
Tuesday Posters
3:45 pm – 5:30 pm
3686 — A0200 Topical Interleukin-1 (IL-1)
Receptor Inhibition Reduces Ocular Pain. Eric
S. Furfine1, R. Dana2, C. Wheeler1, A. Celniker1,
M. H. Goldstein1. 1R&D, Eleven Biotherapeutics,
Cambridge, MA; 2Department of Ophthalmology,
MA *CR, f
3689 — A0203 Dry Eye Response to Topical
Steroids: an in vivo Confocal Study. Edoardo
Villani1, 2, E. Garoli1, 3, V. Canton1, 3, V. Termine1,
R. Ratiglia1, 3, P. Nucci1, 2. 1Clinical Sciences and
Community Health, University of Milan, Milan,
Italy; 2University Eye Clinic, San Giuseppe
Hospital, Milan, Italy; 3Fondazione IRCCS Ca’
Granda Ospedale Maggiore Policlinico, Milan, Italy
3706 — A0220 Measurements performed
with the ocular response analyzer and their
correlation to Goldmann applanation tonometry
in mucopolysaccharidosis patients and healthy
subjects. Joanna Wasielica-Poslednik1, G. Politino1,
I. Schmidtmann2, N. Pfeiffer1, S. Pitz1. 1Department
of Ophthalmology, University Medical Center of
the Johannes Gutenberg University Mainz, Mainz,
Germany; 2Institute for Medical Biostatistics,
Epidemiology and Informatics (IMBEI), University
Medical Center of the Johannes Gutenberg
University Mainz, Mainz, Germany *CR, f
3707 — A0221 Corneal thinning during air
puff indentation. Ying Hon1, T. Li2, Y. Zheng2,
A. Lam1. 1School of Optometry, The Hong Kong
Polytechnic University, Hong Kong, Hong
Kong; 2Interdisciplinary Division of Biomedical
Engineering, The Hong Kong Polytechnic
University, Hong Kong, Hong Kong
3708 — A0222 Viscoelastic Characterization
of the Corneal Stroma assessed Ex Vivo using
Atomic Force Microscopy. Janice Dias, N.
M. Ziebarth. Dept. of Biomedical Engineering,
University of Miami, Coral Gables, FL
Tuesday Posters
3:45 pm – 5:30 pm
3709 — A0223 Depth-dependent mechanical
anisotropy of the cornea assessed by atomic force
microscopy. Cristina Labate1, 2, J. Dias1, V. Sueiras1,
M. De Santo2, G. Lombardo2, M. Lombardo2, N.
M. Ziebarth1. 1Dept. of Biomedical Engineering,
University of Miami College of Engineering,
Miami, FL; 2Phisics, University of Calabria, Reggio
Calabria, Italy
3710 — A0224 Characterization of Corneal
Biomechanical Response Parameters in Pellucid
Marginal Dystrophy, Keratoconus and Normal
Corneas. Janine Lenk, M. Haustein, E. Spoerl,
L. E. Pillunat. University of Dresden, Dresden,
Germany
3711 — A0225 The changes of the corneal
biomechanical parameters according to the level
of HbA1c in diabetes mellitus. Yeon Ggoch Park,
K. Choi, R. Jun. Department of Ophthalmology,
Ewha Womans University, School of Medicine,
3712 — A0226 Test-retest variability of Corvis
measurements in Normal and Keratoconus
Eyes. Vishal Jhanji1, 2, G. Lai1, M. Yu1, C. K.
Leung1. 1Ophthalmology & Visual Sciences,
Chinese Univ of Hong Kong, Kowloon, Hong
Kong; 2Centre for Eye Research Australia,
Melbourne, VIC, Australia
3713 — A0227 Numerical Representation of
Collagen Fibril Anisotropic and Density Related
Stiffness: The Intact Human Eye Globe. Ahmed
Elsheikh1, C. Whitford1, S. Hassaan1, A.
Mohammadvali1, R. Magalhaes2, C. Boote3. 1School
of Engineering, University of Liverpool, Liverpool,
United Kingdom; 2Department of Engineering,
University of Lavras, Lavras, Brazil; 3School of
Optometry & Vision Sciences, Cardiff University,
Cardiff, United Kingdom
3714 — A0228 The Effects of Cross-linking
on the Static and Dynamic Corneal Viscoelastic
Properties. Nandor Bekesi, A. de la Hoz, S. Kling,
S. Marcos. Institute of Optics, CSIC, Madrid, Spain
3715 — A0229 Collagen Crimp Period in
the Corneoscleral Shell. Ning-Jiun Jan1, 2, J. L.
Grimm1, B. Wang2, 1, K. L. Lathrop1, H. Tran1, 2,
G. Wollstein2, L. Kagemann2, H. Ishikawa2, J.
S. Schuman1, I. A. Sigal1, 2. 1Ophthalmology,
University of Pittsburgh, Pittsburgh, PA;
2
Bioengineering, University of Pittsburgh,
Pittsburgh, PA
3716 — A0230 High-resolution biomechanical
characterization of keratoconus cornea ex vivo
with Brillouin microscopy. Giuliano Scarcelli1, S.
Besner1, R. Pineda2, S. H. Yun1.1Wellman Center
for Photomedicine, Harvard Medical School,
Cambridge, MA; 2Massachusetts Eye and Ear
Infirmary, Boston, MA *CR
3717 — A0231 Concordance between corneal
biomechanical testing and Scheimpflug
tomography for keratoconus detection. Pablo
R. Ruisenor Vazquez1, 2, J. D. Galletti1, 2, N. X.
Minguez1, 2, M. Delrivo2, F. Fuentes Bonthoux2, T.
Pförtner2, J. G. Galletti2. 1Ophthalmology, Hospital
de Clínicas, University of Buenos Aires, Buenos
Aires, Argentina; 2ECOS (Clinical Ocular Studies)
Laboratory, Buenos Aires, Argentina
3718 — A0232 Characterization of cornea
biomechanics by Brillouin microscopy:
Instrument and initial in vivo data. Sebastien
Besner1, 2, G. Scarcelli1, 2, R. Pineda3, S. H.
Yun1, 2. 1Department of Dermatology, Harvard
Medical School, Boston, MA; 2Wellman Center for
Photomedicine, Massachusetts General Hospital,
Boston, MA; 3Department of Ophthalmology,
MA *CR
3719 — A0233 The Effect of Hypothyroidism
on Mechanical and Biochemical Properties
of the Cornea. Conrad Hoffmann, E. Spoerl.
Department of Ophthalmology, Dresden University
of Technology, Dresden, Germany
3720 — A0234 Pentacam Densiometry
Method for Analysis of Cross-linking in Whole
Porcine Globes. Sarah Peterson, S. Herekar, M.
D. Friedman, E. A. Sherr, D. Muller. Avedro, Inc,
Waltham, MA *CR
3721 — A0235 Confocal Brillouin scanning
microscope for estimation of corneal stiffness.
Amit Paranjape, S. Peterson, M. D. Friedman, D.
Muller. R&D, Avedro Inc., Waltham, MA *CR
3722 — A0236 Effects of corneal collagen
crosslinking on Ocular Response Analyzer
Waveform-derived variables in keratoconus
and post-LASIK ectasia. Katie M. Hallahan1,
K. Rocha1, A. Sinha Roy2, J. B. Randleman3,
R. Stulting4, W. J. Dupps1. 1Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 2Clinical Imaging
and Biomechanics, Narayana Nethralaya Eye
Hospital, Bangalore, India; 3Emory Eye Center,
Emory Healthcare, Atlanta, GA; 4Stulting Research
Center, Woolfson Eye Institute, Atlanta, GA *CR, f
3723 — A0237 Corneal biomechanical
properties as a predictor of surgically induced
astigmatism during cataract surgery. Mathew
Kurian Kummelil1, 2, R. Shetty1, A. Sinha Roy1, P.
R. Srivatsa1, R. M. Nuijts2. 1Nararyana Nethralaya,
Bangalore, India; 2Department of Ophthalmology,
University of Maastricht, Maastricht, Netherlands
3724 — A0238 Quantitative In Vivo Corneal
Elastography by Doppler Shear Wave
Imaging. Matthew R. Ford1, 2, A. M. Rollins2, W.
J. Dupps1. 1Ophthalmic Research, Cleveland Clinic
Cole Eye Institute, Cleveland, OH; 2Biomedical
Engineering, Case Western Reserve University,
Cleveland, OH *CR
3725 — A0239 The Scheimpflug corneal
deformation response parameters for different
diagnoses in a glaucoma clinic. Wan Haslina1, 2,
M. Nessim1, S. Naroo1, S. Shah1. 1VIsual Science
Department, Aston University, birmingham, United
Kingdom; 2Ophthalmology Department, Universiti
Kebangsaan Malaysia Medical Centre, Kuala
Lumpur, Malaysia
3726 — A0240 Electric field mediated
alignment of collagen fibers in collagen
Vitrigel materials. Shoumyo Majumdar1, X.
Calderon-Colon2, M. Trexler2, O. Schein3, J.
Elisseeff1.1Translational Tissue Engineering Center,
Johns Hopkins University, Baltimore, MD; 2Applied
Physics Laboratory, Johns Hopkins University,
Laurel, MD; 3Department of Ophthalmology,
Wilmer Eye Institute, Johns Hopkins School of
Medicine, Baltimore, MD
3727 — A0241 Corneal strains during small
cyclic IOP fluctuations. Hong Chen1, X. Pan2, 1,
P. A. Weber3, J. Liu1, 3. 1Department of Biomedical
Engineering, Ohio State University, Columbus, OH;
2
Center for Biostatistics, Ohio State University,
Columbus, OH; 3Department of Ophthalmology,
Ohio State University, Columbus, OH *CR
3728 — A0242 Effects of Corneal Edema
on Tonometry Measurements and Corneal
Biomechanical Properties as Evaluated by
Inflation Testing and Uniaxial Rheometry.
Hugh J. Morris1, Y. Liew1, B. Cruz Perez1, X.
Pan2, P. A. Weber3, J. Liu1, 3. 1Department of
Biomedical Engineering, Ohio State University,
Columbus, OH; 2Center For Biostatistics, Ohio
State University, Columbus, OH; 3Department of
Ophthalmology, Ohio State University,
Columbus, OH
3729 — A0243 Calculation of a Keratoconus
Match Index for CorVis ST. Michael Haustein,
E. Spoerl, L. E. Pillunat. Dept Ophthalmology,
University of Dresden, Dresden, Germany
260
3730 — A0244 Predicting spherical aberration
induced by laser refractive surgery by using
biomechanical model of cornea. Mengchen
Xu1, 2, A. L. Lerner1, 3, A. Richhariya4, G. Yoon2, 3.
1
Department of Mechanical Engineering,
University of Rochester, Rochester, NY; 2Flaum
Eye Institute, University of Rochester, Rochester,
NY; 3Department of Biomedical Engineering,
University of Rochester, Rochester, NY; 4L V
Prasad Eye Institute, Kallam Anji Reddy Campus,
Hyderabad, India
3731 — A0245 Biomechanical properties of
the cornea in children with juvenile idiopathic
arthritis. A case-control study. Miriam A. RamosHdez, C. L. Soria-Orozco, P. Madrigal-Ruiz, J. A.
Paczka, E. A. Roig-Melo, M. Barba, R. Moreno.
Clinicas quirugicas, Inst de Oftalmol y Ciencias
Visuales, Guadalajara, Mexico
3732 — A0246 Corneal biomechanics and
24-hour continuous intraocular pressure
(IOP) monitoring using a contact lens sensor
(CLS) in progressive primary open angle
glaucoma (POAG): BIOLENS study. Cedric
Schweitzer, J. Lindell, R. Goedkoop, J. Korobelnik.
Ophthalmology, University Hospital Pellegrin,
Bordeaux, France *CR, f
3734 — A0248 Sterile Vitritis after Boston
Keratoprosthesis. Christina M. Grassi, A. Crnej, K.
Colby, C. H. Dohlman, J. Chodosh. Ophthalmology,
3735 — A0249 Tumor Necrosis Factor Alpha
and Leptin Levels in Boston Keratoprosthesis
Patients: Preliminary Data. Eleftherios I.
Paschalis1, E. Taniguchi1, A. Crnej1, K. Colby1,
L. R. Pasquale2, J. Chodosh1, C. H. Dohlman1,
L. Q. Shen2. 1Ophthalmology - Cornea Service,
Massachusetts Eye and Ear Infirmary - Harvard
Medical School, Boston, MA;2Ophthalmology Glaucoma Service, Massachusetts Eye and Ear
Infirmary - Harvard Medical School, Boston, MA
3737 — A0251 Long-term static force
testing on three MOOKP bonding agents
during traumatic ocular simulation: 2-year
results. Varona Sargent1, M. C. Aguilar1, Y.
Sawatari2, 3, A. Gonzalez1, W. Lee1, C. Rowaan1,
D. Miller2, 4, V. L. Perez2, E. C. Alfonso2, J. A.
Parel1, 5. 1Ophthalmic Biophysics Center, Bascom
Palmer Eye Institute, University of Miami
Miller School of Medicine, Miami, FL; 2Anne
Bates Leach Eye Hospital, Bascom Palmer Eye
Institute, University of Miami Miller School of
Medicine, Miami, FL; 3Oral Maxillofacial Division,
Department of Surgery, University of Miami
Miller School of Medicine, Miami, FL; 4Ocular
Institute, University of Miami Miller School
of Medicine, Miami, FL; 5Vision Cooperative
Research Centre, Brien Holden Vision Institute,
UNSW, Sydney, NSW, Australia
3738 — A0252 Boston Type 1 Keratoprosthesis
outcomes and complications, our experience. Ana
Orive, A. Santamaria, B. Arana, B. Berasategui, B.
Jiménez Gómez, R. Feijoo, J. Etxebarria. Cruces
University Hospital, Bilbao, Spain
3739 — A0253 Improving Bandage Contact
Lens Fits in Boston Keratoprosthesis
Patients. Julia Theodossiades1, S. Shah1, M. R.
Wilkins2. 1Contact Lens Service, Moorfields Eye
Hospital, London, United Kingdom; 2External
Disease Service, Moorfields Eye Hospital, London,
United Kingdom
3740 — A0254 Contralateral Eye Comparison
in of two different types of keratoprostheses
in setting of buphthalmos and multiple
corneal transplant failures: optical quality,
implications and critical lessons. Alice Zhu1, 3,
J. J. Ma2, 1. 1Veritas Eye Institute, Toronto, ON,
Canada; 2University of Toronto, Toronto, ON,
Canada; 3Corneal and Vision Science Foundation,
Toronto, ON, Canada
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Visual Psychophysics / Physiological Optics /
Lens
378 IOL and Accomodation
Moderators: Patricia A. Piers and
Pete S. Kollbaum
3741 — B0001 Accuracy of the positioning of
virtual toric intraocular lenses by unassisted
axis evaluation. Valérie Mané1, A. Rouquette2,
M. Guedj1, A. Queant1, D. Monnet1, A. P. Brezin1.
1
Service d’ophtalmologie, Université Paris
Descartes, Assistance Publique - Hôpitaux de
Paris, Cochin-Hôtel-Dieu, Paris, France; 2Unité
de Biostatistique et Epidémiologie, Assistance
Publique - Hôpitaux de Paris, Hôtel-Dieu, Paris,
France
3742 — B0002 Visual Outcomes and
Complications in a Comparative Study of
Visian Implantable Contact Lens and Artisan
Iris-fixated Phakic Intraocular Lens in a
Myopic Cohort. Abdulelah Al-Abdullah1, 2, M.
Alfalah1, R. Khandekar3, S. A. Alreshaid1, J.
Arevalo1, 4. 1Vitreoretinal division, King Khaled Eye
Specialist Hospital, Riyadh, Saudi Arabia; 2Uveitis
division, King Khalid eye specialist hospital,
Riyadh, Saudi Arabia; 3Research department, King
Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia; 4Retina Division, The Wilmer Eye Institute,
The Johns Hopkins University School of Medicine,
Baltimore, MD
3743 — B0003 Visual Performance of a New
Segmented Asymmetric Multifocal IOL. Emma
Berrow, S. Shah, J. Wolffsohn, S. Naroo, P. Bilkhu.
Life and Health Sciences, Aston University,
Birmingham, United Kingdom
3744 — B0004 Refractive and morphometric
changes during incipient presbyopia: the Aston
Longitudinal Assessment of Presbyopia (ALAP)
study 18 month review. Deborah S. Laughton, A.
L. Sheppard, L. N. Davies. Ophthalmic Research
Group, Life & Health Sciences, Aston University,
Birmingham, United Kingdom
3745 — B0005 A Best-Eye Model of Binocular
Summation with Presbyopic Contact Lens
Corrections. Pete S. Kollbaum1, S. Huenink1, R.
McGiffen1, M. Rickert1, J. Tarrant2, P. Chamberlain2.
1
Optometry, Indiana University, Bloomington,
IN; 2CooperVision, Pleasanton, CA *CR
3746 — B0006 Design of Accommodating
Intra-ocular Lens--Synthesis of Organosilica
Nanoparticles. Paul D. Hamilton1, 2, N.
Ravi1, 3. 1Research, VA Health Care System,
St Louis, MO; 2Ophthalmology, Washington
University School of Medicine, S. Louis,
MO; 3Chemical Engineering, Washington
University, St. Louis, MO
261
Tuesday Posters
3:45 pm – 5:30 pm
3733 — A0247 Immunogenicity of the fish
scale-derived collagen matrix for corneal
reconstruction. T H. van Essen1, L. van Zijl2,
A. A. Mulder3, S. J. Sparks2, C. C. Lin2, H.
J. Lai2, G. P. Luyten1, A. Ghalbzouri3, M.
Jager1. 1Ophthalmology, Leiden Univ Medical
Center, Leiden, Netherlands; 2Research,
Aeon Astron Europe BV, Leiden,
Netherlands; 3Dermatology, Leiden Univ Medical
Center, Leiden, Netherlands *CR
3736 — A0250 The role of surface quality of
keratoprostheses in microbial adherence and
biofilm formation. Shawn P. Kelly1, H. A. Durkee1,
D. Miller2, 3, M. C. Aguilar1, G. Amescua3, V. L.
Perez3, E. C. Alfonso3, J. A. Parel1, 4. 1Ophthalmic
Biophysics Center, Bascom Palmer Eye Institute,
Miami, FL; 2Ocular Microbiology Laboratory,
Bascom Palmer Eye Institute, University of Miami
Miller School of Medicine, Miami, FL; 3Anne Bates
Leach Eye Hospital, Bascom Palmer Eye Institute,
Miami, FL; 4Vision Cooperative Research Centre,
Brien Holden Vision Institute, UNSW, Sydney,
NSW, Australia
3747 — B0007 long term results on visual
function of apodized multifocal IOLs. Enzo
M. Vingolo1, E. Rigoni1, C. Carnevale3, 1, P. G.
Limoli2, D. Domanico1. 1UOC Ophthal Hosp
“Fiorini” LT, University La Sapienza of Rome,
Roma, Italy; 2Centro Stdi Ipovisione, Milano,
Italy; 3Ophthalmology, University La Sapienza,
Rome, Italy
3756 — B0016 development of a convenient
system for measuring forward light scattering
from intraocular lenses. Kazuhiko Ohnuma1,
T. Noda2, H. Matsushima3. 1Center for Frontier
Medical Eng., Chiba University, Chiba-shi,
Japan; 2Ophthalmology, National Hospital
Organization, Tokyo, Japan;3Ophthalmology,
Dokkyo Medical University, Tochigi, Japan
3748 — B0008 Extending the Range of Vision,
using Diffractive IOL technology. Henk A.
Weeber, S. Meijer, C. Canovas, P. van Wijk, P.
A. Piers. R&D, AMO Groningen BV, Groningen,
Netherlands *CR
3757 — B0017 In Situ Measurement of
Dysphotopsia of IOLs. Huawei Zhao. R & D,
Abbott Medical Optics, Santa Ana, CA *CR
3749 — B0009 Comparison of Astigmatism
Calculation Methods for FDA approved
Toric Intraocular Lenses. Fatma Dihowm1, D.
Hjelmstad2, 1, S. I. Sayegh1. 1The Eye Center,
Champaign, IL; 2Arizona State University,
Phoenix, AZ
3750 — B0010 Association between grade of
intraocular lens glistenings and in vitro forward
light scatter. Eva Philippaki1, A. Doraiswamy2,
C. C. Hull1. 1Applied Vision Research Center,
City University London, London, United
Kingdom; 2Advanced Vision Science, Inc., Goleta,
CA *CR
Tuesday Posters
3:45 pm – 5:30 pm
3751 — B0011 Safety and Efficacy
assessment of Iris-fixated phakic intraocular
lens implantation after retinal detachment
surgery. Jin Kwon Chung, S. Ha, S. Lee.
Department of Ophthalmology, Soonchunhyang
University, College of Medicin, Seoul, Republic of
Korea
3752 — B0012 Visual performance evaluation
of a new multifocal intraocular lens design before
surgery. Jaume Pujol1, M. Aldaba1, A. Giner1, J.
Arasa1, S. O. Luque2. 1CD6-Optica i Optometria,
Universitat Politecnica Catalunya, Terrassa, Spain;
2
10Lens S.L.U., Terrassa, Spain *CR
3753 — B0013 Theoretical comparison
of optical quality with a spherical and two
aspheric intraocular lenses. Takushi Kawamorita1,
H. Uozato1, K. Shimizu2. 1Orthoptics and
Visual Science, Kitasato University School
of Allied Health Sciences, Sagamihara-shi,
Japan; 2Ophthalmology, Kitasato University School
of Medicine, Sagamihara, Japan
3754 — B0014 Analysis of ocular higher-order
aberrations and visual functions one month after
implantation of four aspheric IOLs. Naofumi
Kita1, S. Eguchi1, H. Mori1, H. Masahara1, S.
Takagi2, K. Oohashi1. 1Eguchi Eye Hospital,
Hakodate, Japan; 2Toho University Ohashi Medical
Center, Tokyo, Japan f
3755 — B0015 Comparing in vivo and in vitro
optical characteristics of diffractive multifocal
IOLs with different add powers. Michelle
Langeslag1, S. Schmickler2, R. Pohl3, K.
Featherstone4, P. A. Piers1. 1AMO Groningen
BV, Groningen, Netherlands; 2Augen-ZentrumNordwest, Ahaus, Germany; 3AMO Ettlingen
GmbH, Ettlingen, Germany; 4Abbott Medical
Optics Inc, Santa Ana, CA *CR, f
3758 — B0018 Open-view real-time binocular
optical sensor. Emmanuel Chirre, P. Prieto, P. Artal.
Laboratorio de Optica, Universidad de Murcia,
Murcia, Spain
3759 — B0019 Functional evaluation of
Accomodative IOL Soleko FIL-618A. Nicola
Cardascia, C. Palmisano, P. Ferreri, F. Passidomo,
G. Alessio. Oftalmologia, Policlinico Bari Univ di
Bari A Moro, Bari, Italy
3760 — B0020 Accommodation error with
single vision, bifocal and multifocal soft
commercial contact lenses. Ravi C. Bakaraju1,
C. Fedtke1, K. Ehrmann1, 2, D. Falk1, J. Chung1,
A. Ho1, 2, B. A. Holden1, 2. 1Brien Holden Vision
Institute, Sydney, NSW, Australia; 2School of
Optometry and Vision Science, Sydney, NSW,
Australia *CR, f
3761 — B0021 Effects of Intralenticular
Photodisruption Without Capsulotomy on
Post-operative Intraocular Pressure. Ajay
Pillai1, S. Shah2, R. Gil Cazorla3, K. H. Edwards1,
H. S. Uy4. 1Clinical Research, LENSAR, Inc.,
Orlando, FL; 2Midland Eye Institute, Solihull,
United Kingdom; 3Optometry, Aston University,
Birmingham, United Kingdom; 4Pacific Eye &
Laser Institute, Makati City, Philippines *CR
3762 — B0022 Vergence and Accommodation
in Down Syndrome: exploring the role of
disparity and blur cues. Lesley Doyle, J. Little,
K. J. Saunders. Vision Science Research Group,
University of Ulster, Coleraine, United Kingdom
3763 — B0023 Comparison of Objective and
Subjective Accommodative Response from
Preschool to Pre-Presbyopia. Tawna L. Roberts1,
K. K. Stuebing2, H. A. Anderson1.1College of
Optometry, University of Houston, Houston,
TX; 2TIMES Institute, University of Houston,
Houston, TX
3764 — B0024 The effect of alpha-linolenic
acid level on static and dynamic accommodative
stability in healthy presbyopes. Aina Edvinsen,
A. Heim, T. Langaas, S. J. Gilson, R. Baraas.
Optometry and Visual Science, Buskerud and
Vestfold University College, Kongsberg, Norway
3765 — B0025 Dioptin™: A novel
pharmaceutical formulation for restoration
of accommodation in presbyopes. Kathryn S.
Crawford1, 2, W. H. Garner2, W. Burns2. 1PharmOcu,
Andover, MA; 2Research, Encore Vision, Fort
Worth, TX *CR
3766 — B0026 Dioptin™ Eye Drop to Treat
Presbyopia: corneal penetration and ocular
pharmacokinetics. William H. Garner1, M.
Garner1, K. S. Crawford1, 2, W. Burns1.1Research,
Encore Vision, Fort Worth, TX; 2PharmOcu,
Andover, MA *CR
3767 — B0027 Dioptin™ Eye Drop Increases
Mouse Lens Elasticity. Margaret Garner, W. H.
Garner, W. Burns. Research, Encore Vision, Fort
Worth, TX *CR
3768 — B0028 Refractive error, ocular axial
length and accommodation in presbyopes living
in Southern Norway. Anette Heim, A. Edvinsen, T.
Langaas, P. O. Lundmark, S. J. Gilson, R. Baraas.
Optometry and visual science, Buskerud and
Vestfold University College, Kongsberg, Norway
3769 — B0029 Exploring Accommodative
accuracy in Autism Spectrum Disorder. JulieAnne Little, P. Anketell, L. Doyle, K. J. Saunders.
Vision Science Research Group, University of
Ulster, Coleraine, United Kingdom
3770 — B0030 Reduced accommodation in
children with Autism Spectrum Disorder. Pamela
Anketell1, K. J. Saunders1, S. M. Gallagher2, J.
Little1. 1Biomedical Sciences, University of Ulster,
Coleraine, United Kingdom; 2School of Psychology,
University of Ulster, Coleraine, United Kingdom
3771 — B0031 Accommodation and Pupil
Reaction using Accommodative and Light
stimulus in Dynamic Characteristics. Hiroshi
Uozato1, 2, S. Arai1, Y. Shibata1.1Ophthalmology/
Visual Science, Kitasato Univ Grad Sch of Med Sci,
Sagamihara, Japan; 2Orthoptics and Viusal Sciences,
Kitasato University School of Allied Health
Sciences, Sagamihara, Japan
3772 — B0032 Evidence that Accommodative
Microfluctuations provide Odd-Error Cues to
Accommodation and Insights into the Potential
Spatial Cues. Sangeetha Metlapally1, J. Tong2,
H. Tahir3, C. M. Schor1. 1School of Optometry,
University of California, Berkeley, Berkeley,
CA; 2Brain Trauma Foundation, New York,
NY; 3Faculty of Life Sciences, University of
Manchester, Manchester, United Kingdom
3773 — B0033 Can Accommodation in PrePresbyopic Population be Predicted Accurately
with Ultrasound Biomicroscopy? Viswanathan
Ramasubramanian, A. Glasser. College of
Optometry, University of Houston, Houston, TX
3774 — B0034 Abnormal fluctuations of
the accommodation in Patients with mild
Keratoconus. Akio Miyakoshi, T. Nakamura, N.
Tojo, A. Hayashi. university of toyama, Toyama,
Japan
3775 — B0035 Predictors of the subjective
range of clear vision in pseudophakes. Sandeep
K. Dhallu1, J. S. Wolffsohn1, A. L. Sheppard1,
T. E. Drew1, T. Mihashi2. 1Vision Sciences
Department, Aston University, Birmingham, United
Kingdom; 2Tokyo Institute of Technology, Tokyo,
Japan
262
3776 — B0036 Lens Spherical Aberrations in
Cynomolgus Monkeys: Comparison of Laser
Ray Tracing Measurements and Reconstructed
GRIN Model Predictions. Bianca M. Maceo1, 2, A.
de Castro3, J. Birkenfeld3, E. Arrieta1, J. A. Parel1, 4,
S. Marcos3, F. Manns1, 2. 1Ophthalmic Biophysics
Center, Bascom Palmer Eye Institute, Miami,
FL; 2Department of Biomedical Engineering,
University of Miami, Biomedical Optics and Laser
Laboratory, Coral Gables, FL; 3Consejo Superior
de Investigaciones Científicas, Instituto de Óptica,
Madrid, Spain;4Vision Cooperative Research
Centre, Brien Holden Vision Institute, UNSW,
Sydney, NSW, Australia
3777 — B0037 Ciliary muscle contraction
force and trapezius muscle activity during
manual tracking of visual targets. Hans O.
Richter1, D. Domkin1, M. Forsman2, 1.1Department
of Occupational and Public Health Sciences,
Gävle University, Gävle, Sweden; 2Institute of
Environmental Medicine, Karolinska Institutet,
Stockholm, Sweden
3778 — B0038 Optical vergence detection
across the pupil for accommodation,
emmetropization and visual perception. Philip B.
Kruger1, L. R. Stark2. 1Graduate Center for Vision
Research, State University of New York, New York,
NY; 2Southern California College of Optometry,
Marshall B. Ketchum University, Fullerton, CA
3779 — B0039 Forward movement of the
crystalline lens plays an important role in
accommodation. Ji C. He1, J. Wang2, M. Wei1, J.
Mao1. 1New England College of Optometry, Boston,
MA; 2Bascom Palmer Eye Institute, Miami, FL
3781 — B0041 Diffusers Induced Ocular Light
Scattering Measured By A Psychophysical And
An Optical Method. Marrie Van der Mooren1,
H. S. Ginis2, R. Rosén1, A. Benito2, L. Franssen1,
A. Pennos2, D. Christaras2, P. A. Piers1, P.
Artal2. 1Applied Research, AMO Groningen BV,
Groningen, Netherlands; 2Laboratorio de Optica,
Universidad de Murcia, Murcia, Spain *CR
3782 — B0042 Evaluation of Surface Light
Scattering and Posterior Capsular Opacification
Using Rotating Scheimpflug Imaging
System. Keiichiro Minami, M. Honbou, Y. Mori, K.
Miyata. Miyata Eye Hospital, Miyakonojo, Japan
3783 — B0043 Imaging crystalline lens
microscopic structures of intact in vitro mammal
lenses using confocal microscopy. Judith
Birkenfeld, J. Lamela, S. Ortiz, S. Marcos. CSICInstituto de Optica, Madrid, Spain
3785 — B0045 Calculation of crystalline lens
power using corneal topography and wholeeye biometry with extended-depth Optical
Coherence Tomography. Fabrice Manns1, 2, F.
Cabot1, 3, M. Ruggeri1, A. Ho4, 5, S. H. Yoo1, 3, J. A.
Parel1, 6. 1Ophthalmic Biophysics Center, Bascom
FL; 2Biomedical Optics and Laser Laboratory,
Department of Biomedical Engineering, University
of Miami College of Engineering, Coral Gables,
FL; 3Anne Bates Leach Eye Hospital, Bascom
FL; 4Brien Holden Vision Institute, Sydney, NSW,
Australia; 5School of Optometry and Vision
Science, University of New South Wales, Sydney,
NSW, Australia; 6Vision Cooperative Research
Center, Sydney, NSW, Australia *CR
3786 — B0046 Artificial Iris Implants for
Aniridia & Oculocutaneous Albinism: Does
Near Infra-Red Light Transmission Risk Retinal
Phototoxicity? Imran Yusuf, T. Fung, S. N. Peirson,
C. K. Patel. Nuffield Laboratory of Ophthalmology,
Oxford University, Oxford, United Kingdom
3787 — B0047 Laboratory Analysis of
Different Implant Options for Highly Hyperopic
/ Nanophthalmic Eyes. Bruno L. Trindade1, 2, F. T.
Amaral2, D. W. Monteiro2.1Ophthalmology, Federal
University of Minas Gerais, Belo Horizonte,
Brazil; 2Electrical Engeneering, Federal University
of Minas Gerais, Belo Horizonte, Brazil
3788 — B0048 Crystalline lens gradient
refractive index and posterior surface shape
from multiple orientations OCT imaging:
towards a reconstruction in vivo? Alberto de
Castro1, J. Birkenfeld1, B. M. Maceo2, M. Ruggeri2,
E. A. Arrieta2, J. A. Parel2, 4, F. Manns2, 3, S.
Marcos1. 1Instituto de Óptica, Consejo Superior
de Investigaciones Científicas CSIC, Madrid,
Spain; 2Ophtalmic Biophysics Center, Bascom
Palmer Eye Institute, Miami, FL; 3Biomedical
Engineering, University of Miami, Biomedical
Optics and Laser Laboratory, Miami, FL; 4Vision
Cooperative Research Centre, Sydney, NSW,
Australia
3789 — B0049 Contrast Sensitivity in Eyes
with Retrodots by Difference in Size. Nagai
Kouta1, M. Norihito2, N. Hatsusaka2, R. Honda3,
H. Sasaki2, 4. 1Ophthalmology, Nagai Eye Clinic,
Ibaraki, Japan; 2Ophthalmology, Kanazawa
medical university, Uchinada, Japan; 3School of
Nursing, Kanazawa medical university, Uchinada,
Japan; 4Vision Research for Environmental Health,
Kanazawa medical university, Uchinada, Japan
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Glaucoma
379 Glaucoma genetics
Moderators: Alex W. Hewitt and
Ordan J. Lehmann
3790 — B0158 Interaction between IGF rs6214
and HGF rs3735520 in genetic association
with primary angle-closure glaucoma. Mingzhi
Zhang1, J. Chen1, 2, W. Diao1, J. Duan1, H. Chen1,
C. Pang1, 2. 1Joint Shantou International Eye Center,
Shantou, China; 2Department of Ophthalmology &
Visual Sciences, The Chinese University of Hong
Kong, Hong Kong, Hong Kong, China
3791 — B0159 Exome sequencing of 257
patients with POAG or PACG: mutations
in seven known glaucoma-associated genes.
Qingjiong Zhang, X. Huang, M. Li, X. Guo, S.
Li, X. Xiao, X. Jia, X. Liu, Q. Zhang. Zhongshan
Ophthalmic Center, Sun Yat-Sen University,
Guangzhou, China
3792 — B0160 Identification of diseaseassociated genome variants in regulatory
regions using exome sequencing in 295 POAG
cases. Terry Gaasterland1, 2, D. E. Gaasterland3, L.
E. Edsall4, 8, A. N. Dubinsky3, K. Ding5, S. Head6,
K. H. Willert3, C. The NEIGHBOR7, 8. 1Institute for
Genomic Medicine, Univ of California San Diego,
La Jolla, CA; 2Shiley Eye Center, Univ of California
San Diego, La Jolla, CA; 3Sanford Consortium
for Regenerative Medicine, Univ of California
San Diego, La Jolla, CA; 4Graduate Program
in Genetics and Genomics, Duke University,
Durham, CA; 5Bioinformatics and Systems Biology
Graduate Program, Univ of California San Diego,
La Jolla, CA; 6Next Generation Sequencing
Core, The Scripps Research Institute, La Jolla,
CA; 7Massachusetts Eye and Ear Institute, Harvard,
Boston, MA; 8Duke Center for Human Genetics,
Duke University, Durham, NC
3793 — B0161 Association of LOXL1
polymorphisms with glaucoma risk in subjects
with pseudoexfoliation: a meta-analysis. Fotis
Topouzis1, P. Founti1, 2, A. Chatzikyriakidou3, A.
Haidich4, E. Anastasopoulos1, T. Pappas1, A. C.
Viswanathan5, A. Lambropoulos3. 1Ophthalmology,
School of Medicine, Aristotle University
of Thessaloniki, Thessaloniki,
Greece;2Ophthalmology, St Thomas’ Hospital,
Guy’s and St Thomas’ NHS Foundation Trust,
London, United Kingdom; 3Laboratory of General
Biology, School of Medicine, Aristotle University
of Thessaloniki, Thessaloniki, Greece; 4Department
of Hygiene and Epidemiology, School of Medicine,
Aristotle University of Thessaloniki, Thessaloniki,
Greece; 5NIHR Biomedical Research Centre,
Moorfields Eye Hospital NHS Foundation Trust,
University College London (UCL) Institute of
Ophthalmology, London, United Kingdom
263
Tuesday Posters
3:45 pm – 5:30 pm
3780 — B0040 Changes of accommodative
power in vitrectomized eyes with crystalline
lenses without presbyopia. Ju Byung Chae,
T. Moon, J. Kim. Ophthalmology-Coll of Med,
Chungbuk National University Hospital, Cheongju,
Chung-buk, Republic of Korea
3784 — B0044 OCT 3-D surface topography
of isolated human crystalline lenses. Mengchan
Sun, J. Birkenfeld, A. de Castro, S. Ortiz, P. Perez,
M. Velasco, S. Marcos. Visual Optics and Biophotonics Lab, Instituto de Optica, CSIC, Madrid,
Spain *CR
3794 — B0162 Linkage and association
analyses identify a vCDR locus on chromosome
14q32 in consanguineous pedigrees from
South India. Ryan Wang1, B. Fan1, P. Ferdina
Marie Sharmila2, N. Soumittra2, S. Sripriya2, D.
Friedman3, L. Vijaya4, J. L. Haines5, R. J. George4,
J. L. Wiggs1. 1Department of Ophthalmology,
MA; 2SNONGC Department of Genetics and
Molecular Biology, Vision Research Foundation,
Chennai, India; 3Department of Ophthalmology,
Wilmer Eye Institute, Baltimore, MD;4Medical
Research Foundation, Sankara Nethralaya, Chennai,
India; 5Center for Human Genetic Research,
Vanderbilt University School of Medicine,
Nashville, TN
Tuesday Posters
3:45 pm – 5:30 pm
3795 — B0163 Ethnic-based differences in
the association of LOXL1 polymorphisms with
pseudoexfoliation: a meta-analysis. Panayiota
Founti1, 2, A. Chatzikyriakidou3, A. Haidich4,
A. Lambropoulos3, E. Anastasopoulos1, T.
Pappas1, A. C. Viswanathan5, F. Topouzis1.
1
Ophthalmology, School of Medicine, Aristotle
University of Thessaloniki, Thessaloniki, Greece;
2
Ophthalmology, St Thomas’ Hospital, Guy’s
and St Thomas’ NHS Foundation Trust, London,
United Kingdom; 3Laboratory of General Biology,
School of Medicine, Aristotle University of
Thessaloniki, Thessaloniki, Greece; 4Department
of Hygiene and Epidemiology, School of Medicine,
Aristotle University of Thessaloniki, Thessaloniki,
Greece; 5NIHR Biomedical Research Centre,
University College London (UCL) Institute of
Ophthalmology, London, United Kingdom
3796 — B0164 Investigating pigment
dispersion syndrome using an inducible mouse
model. Michael G. Anderson1, 2, A. HedbergBuenz1, 2. 1Molecular Physiology & Biophysics,
University of Iowa, Iowa City, IA; 2Center for the
Prevention and Treatment of Visual Loss, Veterans
Affairs (VA) Health Care System, Iowa City, IA
3797 — B0165 Additional complexities in
Axenfeld-Rieger Syndrome - implications for
pediatric glaucoma. Ordan J. Lehmann1, M. AsaiCoakwell2, H. Singh2, E. Strachan2.1Ophthalmology
& Medical Genetics, University of Alberta,
Edmonton, AB, Canada; 2Ophthalmology,
University of Alberta, Edmonton, AB, Canada
3798 — B0166 Genetic Mapping of a Novel
Disease Locus in a Canine Model of Primary
Angle Closure Glaucoma. Dina Ahram1, S. D.
Grozdanic2, A. Henkes3, R. W. Collin3, M. H.
Kuehn1. 1Ophthalmology and Visual Sciences,
University of Iowa, Iowa City, IA; 2Animal
Eye Consultants of Iowa, North Liberty, IA;
3
Department of Human Genetics, Radboud
University Medical Center, Nijmegen, Netherlands
3799 — B0167 The retinal nerve fiber layer
is reduced in POAG cases homozygous for
the common Six6 risk-allele of rs33912345
(Asn141His). Shane J. Havens1, J. C. Wen1, M.
Ulmer Carnes2, J. L. Wiggs3, L. R. Pasquale3,
A. E. Ashley-Koch2, M. A. Hauser2, 1, R. R.
Allingham1. 1Ophthalmology, Duke Univeristy
Medical Center, Durham, NC; 2The Center for
Human Genetics, Duke University, Durham,
NC; 3Ophthalmology, Harvard - Massachusetts Eye
and Ear Infirmary, Boston, MA
3800 — B0168 Examination of subjects
with glaucoma who also have cone opsin gene
mutations. Divakar Gupta, K. D. Bojikian, M.
A. Slabaugh, P. P. Chen, J. Neitz, M. Neitz.
Ophthalmology, University of Washington,
Seattle, WA
3801 — B0169 The LTBP2 Gene Exhibits a
Limited Involvement in Primary Congenital
Glaucoma. Subhabrata Chakrabarti1, S. Ganguly3,
M. Kabra1, A. K. Mandal2, S. Senthil2, I. Kaur1, P.
P. Majumder4. 1Brien Holden Eye Research Centre,
L.V. Prasad Eye Institute, Hyderabad, India; 2Jasti
V Ramanamma Childrens Eye Care Centre, L.V.
Prasad Eye Institute, Hyderabad, India; 3University
of California, San Diego, CA; 4National Institute of
Biomedical Genomics, Kalyani, India
3802 — B0170 Analysis of Exocytosis
Regulation by Transcription Factor FOXC1
and its Role in Axenfeld-Rieger Syndrome
Pathogenesis. Alexandra Rasnitsyn, T. Footz, L. P.
Doucette, M. Yu, M. A. Walter. Medical Genetics,
University of Alberta, Edmonton, AB, Canada
3803 — B0171 Polymorphisms of the
endothelial nitric oxide synthase gene in patients
with normal tension glaucoma and high tension
glaucoma. Tomasz Zarnowski, U. Lukasik, E.
Kosior-Jarecka. Medical University, Lublin, Poland
3804 — B0172 Low tension glaucoma in
microfibril deficient mice. John Kuchtey, J.
Kunkel, M. M. McCallister, J. M. Scichilone, R.
W. Kuchtey. Vanderbilt Eye Institute, Vanderbilt
University, Nashville, TN
3805 — B0173 Hypo- and hypermorphic
FOXC1 mutations in dominant primary
congenital glaucoma. Cristina Medina Trillo1, 2, J. J.
Ferre Fernández1, 2, J. Aroca-Aguilar1, 2, L. MoralesFernancez2, 3, C. Mendez-Hernandez2, 3, C. Ayuso4,
J. García2, 3, J. Escribano1, 2. 1Human Genetics
Laboratory, Medical School. University of CastillaLa Mancha, Albacete, Spain;2Cooperative Research
Network on Age-Realted Ocular Pathology,
Visual and Life Quality. RETICS., Carlos III
Health Institute, Madrid, Spain; 3Ophthalmology
Service. San Carlos Hospital Research Institute,.
Complutense University of Madrid, Madrid,
Spain; 4Ophthalmology Service, Jiménez Díaz
Foundation, CIBERER, Madrid, Spain
3806 — B0174 CYP1B1 mutation carrier
frequency in a normal population residing in
the United States. Keri Allen1, A. Langguth2, K.
Linkroum1, M. Janessian1, D. Wang1, E. Delbono1,
J. L. Wiggs1. 1Ophthalmology, Massachusetts Eye
and Ear Infirmary, Malden, MA; 2University of
Iowa Carver College of Medicine, Iowa City, IA
3807 — B0175 Rare Genetic Variants are
Associated with POAG in Populations of
African Ancestry. Michael A. Hauser1, 2, A. E.
Ashley-Koch1, X. Qin1, S. Strickland1, Y. Liu1, 2,
C. A. Girkin3, D. L. Budenz4, S. Akafo5, R. R.
Allingham2. 1Medicine, Duke Univ Medical Center,
Durham, NC; 2Ophthalmology, Duke University
Medical Center, Durham, NC;3Ophthalmology,
Univ Alabama Birmingham, Birmingham,
AL; 4Ophthalmology, Univ of North Carolina,
Chapel Hill, NC; 5Unit of Ophthalmology,
University of Ghana Medical School, Accra, Ghana
3808 — B0176 Next-Generation Exome
Sequencing of Primary Congenital Glaucoma
(PCG) Families. Roshanak Sharafieh1, P. Khaw2,
B. W. Fleck3, M. E. Turacli4, F. Lopez-Giraldez5,
K. Bilguvar5, R. P. Lifton5, S. Mane5, A. H. Child6,
M. Sarfarazi1. 1Molecular Ophthalmic Genetics
Laboratory, University of Connecticut Health
Center, Farmington, CT; 2NIHR Biomedical
Research Centre, Moorfields Eye Hospital
& UCL Institute of Ophthalmology, London,
United Kingdom; 3Ophthalmology, Royal
Hospital for Sick Children, Edinburgh, United
Kingdom; 4Ophthalmology, University of Ankara,
Ankara, Turkey; 5Yale Center for Genome Analysis
(YCGA), Yale School of Medicine, New Haven,
CT; 6Cardiovascular Genetics, St George’s,
University of London, London, United Kingdom
3809 — B0177 Genomic (epigenetic) DNA
methylation in patients with open-angle
glaucoma. Anselm G. Junemann1, B. Lenz2, U.
Reulbach3, U. Schlotzer-Schrehardt1, R. Rejdak4, 5,
S. Bleich6. 1Ophthalmology, University of Erlangen
Nurnberg, Erlangen, Germany; 2Department
of Psychiatry and Psychotherapy,
University of Erlangen Nürnberg, Erlangen,
Germany; 3Department of Child and Adolescent
Psychiatry, Our Lady, Dublin, Ireland; 4Department
of General Ophthalmology, Medical University
of Lublin, Lublin, Poland; 5Medical Research
Centre, Polish Academy of Sciences, Warsaw,
Poland; 6Clinic of Psychiatry, Socialpsychaitry
and Psychotherapy, Hannover Medical School,
Hannover, Germany f
3810 — B0178 Epidemiology and Exome
Variants analysis of Quantitative Traits related
to Glaucoma in three Sardinian isolated
populations. Roberta Farci1, L. Portas2, F.
Murgia2, G. Biino2, 3, G. Caminiti1, G. Cappai1,
C. Malloci1, M. Cosso2, M. Fossarello1, M.
Pirastu2. 1Ophthalmology Department, University
of Cagliari, Cagliari, Italy; 2Institute of Population
Genetics, National Research Council of Italy,
Sassari, Italy; 3Institute of Molecular Genetics,
National Research Council of Italy, Pavia, Italy
264
3811 — B0179 Association Analysis between
CDKN2B-AS1 Genotype and Quantitative Traits
of Primary Open-Angle Glaucoma. Yoko Ikeda1,
K. Mori1, M. Ueno1, M. Nakano2, Y. Tokuda2,
N. Omi2, R. Sato2, K. Yoshii3, K. Tashiro2, S.
Kinoshita1. 1Ophthalmology, Kyoto Prefectural
Univ of Medicine, Kyoto, Japan; 2Genomic Medical
Sciences, Kyoto Prefectural University of Medicine,
Kyoto, Japan; 3Medical Statistics, Kyoto Prefectural
University of Medicine, Kyoto, Japan *CR
3812 — B0180 CDKN2B-AS1 associations with
Primary Open-Angle Glaucoma related features
in Chinese patients from Singapore. Zheng
Li1, C. Khor2, M. Baskaran1, S. Perera1, D. Su1,
D. Goh1, R. Husain1, J. Chua1, T. Aung1, 3, E. N.
Vithana1, 3. 1Singapore Eye Research Institute,
Singapore National Eye Center, Singapore,
Singapore; 2Genome Institute of Singapore,
Singapore, Singapore; 3Ophthalmology, National
University Health System & National University of
3813 — B0181 Relationship between cone opsin
gene variants and the risk for glaucoma. Karine
D. Bojikian, M. A. Slabaugh, P. P. Chen, J.
Neitz, M. Neitz. Ophthalmology, University of
Washington, Seattle, WA
3815 — B0183 Exome Sequencing of Familial
and Sporadic Cases with Pseudoexfoliation
Syndrome (XFS). Mansoor Sarfarazi1, R.
Sharafieh1, R. Ritch2, J. M. Liebmann2, A.
Tarkkanen3, F. Lopez-Giraldez4, K. Bilguvar4,
R. P. Lifton4, S. Mane4, A. H. Child5. 1Molecular
Ophthal Genetics Lab, Univ of Connecticut Health
Ctr, Farmington, CT; 2Einhorn Clinical Research
Center, New York Eye and Ear Infirmary, New
York, NY; 3Ophthalmology, Helsinki University
Central Hospital, Helsinki, Finland; 4Yale Center for
Genome Analysis (YCGA), Yale University School
of Medicine, New Haven, CT; 5Cardiovascular
Genetics, St George’s, University of London,
London, United Kingdom *CR
3816 — B0184 Variants associated with
exfoliation glaucoma affect promoter activity of
the LOXL1 antisense gene. Inas F. Aboobakar1,
Y. Liu2, 3, S. Miura4, J. Wheeler2, X. Qin2, M. Ulmer
Carnes2, B. T. Whigham2, A. E. Ashley-Koch2, M.
A. Hauser2, 3, R. R. Allingham3. 1Duke University
School of Medicine, Durham, NC; 2Department
of Medicine, Duke University Medical Center,
Durham, NC; 3Department of Ophthalmology,
NC; 4Department of Medicine, Kurume University
School of Medicine, Kurume City, Japan
3818 — B0186 Age Effect on Glaucoma
Susceptibility: CD1 vs B6. Matthew Steinhart1,
E. Cone-Kimball1, C. Nguyen1, T. D. Nguyen2,
M. Pease1, S. Chakravarti1, E. Oglesby1, H.
Quigley1. 1Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD; 2Mechanical
Engineering, Johns Hopkins University,
Baltimore, MD
3819 — B0187 Caveolin-Soluble Guanylate
Cyclase Single Nucleotide Polymorphism Score
in Relation to Primary Open Angle Glaucoma in
the NEIGHBORHOOD Consortium. Chunyan
Qiao1, 2, S. Loomis1, J. H. Kang3, M. A. Hauser4,
R. R. Allingham4, N. Wang2, J. L. Haines5, J.
L. Wiggs1, L. R. Pasquale1. 1Ophthalmology,
MA; 2Ophthalmology, Beijing Tongren Eye
Center, Beijing Tongren Hospital, Capital Medical
University, Beijing, China; 3Medicine, Brigham and
Women Hospital, Boston, MA; 4Ophthalmology,
Duke University, Raleigh, NC; 5Epidemiology and
Biostatistics, Case Western Reserve University,
Cleveland, OH
3820 — B0188 A Novel Single Nucleotide
Polymorphism Associated with Glaucoma
in Shiba-Inu and Shih-Tzu Dogs. Masaki
Imayasu1, N. Kanemaki2, A. Meguro3, N.
Mizuki3.1R&D Center, Menicon Co Ltd, Kasugai,
Japan; 2Veterinary Teaching Hospital, Azabu
University, Sagamihara, Japan; 3Ophthalmology,
Yokohama City University School of Medicine,
Yokohama, Japan *CR
3821 — B0189 Association
between GAS7 genetic variant and primary
open-angle glaucoma in the Japanese
population. Fumihiko Mabuchi1, Y. Sakurada1,
S. Yoneyama1, K. Kashiwagi1, Z. Yamagata2, H.
Iijima1. 1Ophthalmology, University of Yamanashi,
Chuo, Japan; 2Health Sciences, University of
Yamanashi, Chuo, Japan
3822 — B0190 Involvement of collagen related genes and its influence on keratoconus
and primary open angle glaucoma patients
in India. Periasamy Sundaresan1, N. Prasanthi1,
G. Gowthaman1, S. R. Krishnadas2, M. Das3, C.
E. Willoughby4. 1Genetics, Aravind Med Res
Foundation, Madurai, India; 2Glaucoma Clinic,
Aravind Eye Hospital, Madurai, India; 3Cornea
Clinic, Aravind Eye Hospital, Madurai, India; 4Eye
and Vision Science, University of Liverpool,
Liverpool, United Kingdom
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Retina
380 Retinal disorders and management
Moderator: Elliott H. Sohn
3823 — C0125 The Characteristic Changes of
Choroid in Patients with VKH by EDI-OCT. Mei
Li, Q. Liu, Y. Li, P. Lian, J. Wang, R. Tian, Y. Luo,
L. Lu. State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Center, Sun Yat-sen
University, Guangzhou, China
3824 — C0126 Ultra-wide-field imaging in
Birdshot retinochoroidopathy. Federico Chait1, L.
Pelegrin1, B. Molins2, V. Llorens1, M. Mesquida1,
M. Sainz de la Maza1, A. Adan Civera1. 1Institut
Clinic d’Oftalmologia, Hospital Clinic Provincial
de Barcelona, Barcelona, Spain; 2Institut
d’Investigacions Biomèdiques Agustí Pi i Sunyer,
IDIBAPS, Barcelona, Spain
3825 — C0127 Fellow eye in retinal vein
occlusion: In vivo microscopic analysis of foveal
microvasculature. Alexander Pinhas1, 2, A. Gan1,
M. Razeen1, N. Shah1, E. Cheang1, 3, C. L. Liu1, 4, A.
Dubra5, 6, T. Y. Chui1, R. B. Rosen1, 7. 1Department of
Ophthalmology, New York Eye and Ear Infirmary,
New York, NY; 2Icahn School of Medicine at Mount
Sinai, New York, NY; 3Stuyvesant High School,
New York, NY; 4Bronx Science High School, New
York, NY; 5Department of Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 6Department
of Biophysics, Medical College of Wisconsin,
Milwaukee, WI; 7Department of Ophthalmology,
New York Medical College, Valhalla, NY *CR
3826 — C0128 Multimodality Diagnostic
Imaging in Serpiginous Choroiditis. Abdallah
Jeroudi, P. Patel, S. Yeh. Ophthalmology, Emory
University School of Medicine, Atlanta, GA
3827 — C0129 Mathematical modeling
of retinal pigment epithelium (RPE)
autofluorescence (AF) with Gaussian
mixture models and non-negative matrix
factorization (NMF).Ansh Johri1, R. Post1,
B. Ganti1, A. A. Fawzi4, P. Sajda3, T. Ach2, C.
A. Curcio2, T. Smith1. 1Ophthalmology, New
York University School of Medicine, New York,
NY; 2Ophthalmology, University of Alabama
at Birmingham, Birmingham, AL; 3Biomedical
Engineering, Columbia University, New
York, NY; 4Ophthal-Feinberg School of Med,
Northwestern University, Chicago, IL
3828 — C0130 Differentiating vitreous
proteomes in idiopathic epiretinal macular
membranes using high-performance liquid
chromatography coupled to tandem mass
spectrometry. Hao Wang, L. Feng, F. Wang.
Ophthalmology, Shanghai Tenth People›s Hospital,
Tongji University School of Medicine, Shanghai,
China
265
Tuesday Posters
3:45 pm – 5:30 pm
3814 — B0182 Copy Number Variants
associated with Glaucoma in the NEIGHBOR
Study. Allison E. Ashley-Koch1, M. E. Garrett1, J.
L. Haines2, J. L. Wiggs3, L. R. Pasquale3, Y. Liu1, 4,
R. R. Allingham4, M. A. Hauser1, 4. 1Medicine,
NC; 2Epidemiology and Biostatistics, Case
Western Reserve University, Cleveland,
OH;3Ophthalmology, Harvard University, Boston,
MI; 4Opthalmology, Duke University Medical
Center, Durham, NC
3817 — B0185 A Novel Protocol for Consistent
and Enhanced Expression of Unmodified
Heterologous CYP1B1 for Functional Genomics
Studies in Glaucoma. Nasreen Ahmed1, R.
Sharma1, M. Faiq2, R. Dada2, D. Saluja3, T.
Dada1. 1Ophthalmology, All India Institute of
Medical Sciences, New Delhi, India; 2Department
of Anatomy,Laboratory for Molecular
Reproduction and Genetics, All India Institute of
Medical Sciences, New Delhi, India; 3Medical
Biotechnology Laboratory,Dr. B. R. Ambedkar
Centre for Biomedical Research, University of
Delhi, Delhi, India
3829 — C0131 Morphologic and functional
outcome of epiretinal membrane surgery
with and without gas tamponade - a pilot
study. Elnaz Emrani1, J. Matlach1, R. Guthoff2, W.
Goebel1. 1Department of Ophthalmology, University
of Wuerzburg, Wuerzburg, Germany; 2Department
of Ophthalmology, University of Duesseldorf,
Duesseldorf, Germany
3830 — C0132 Compliance with the face-down
positioning after vitrectomy and gas tamponade.
Yoshiaki Shimada1, Y. Seno2, T. Mizuguchi2,
A. Tanikawa2, M. Horiguchi2.1Ophthalmology,
Fujita Health Univ Banbuntane Hosp, Nagoya,
Japan; 2Ophthalmology, Fujita Health Univ School
of Medicine, Toyoake, Japan
3831 — C0133 OCT study of macular structure
after vitreoretinal surgery for rhegmatogenous
retinal detachment. Simona Maria Caprani, S.
Donati, S. Battistini, E. Gibin, C. Azzolini. Dept. of
Surgical and Morphological Sciences - Section of
Ophtalmology, University of Insubria, Varese, Italy
Tuesday Posters
3:45 pm – 5:30 pm
3832 — C0134 Molecular Genetics, OCT and
Fundus Autofluorescence (FAF) Patterns in
Peripapillary (Pericentral) Retinal Pigmentary
Degeneration (PRPD). Sherry J. Bass1, J.
Sherman1, 2. 1Clinical Sciences, SUNY College of
Optometry, New York, NY; 2SEI, SUNY College of
Optometry, New York, NY *CR
3833 — C0135 Impact of surgical technique
on outcomes in vitreoretinal surgery after open
globe repair. Kristen H. Nwanyanwu1, R. Kapur2,
H. Bhatt3, 1, N. P. Blair1, J. I. Lim1.1Department of
Ophthalmology and Visual Sciences, Illinois Eye
and Ear Infirmary, University of Illinois at Chicago,
Chicago, IL; 2Retina Consultants, Ltd., Des Plaines,
IL; 3University Retina, Oak Forest, IL
3834 — C0136 Interval changes in patients
with Susac’s syndrome on wide-field fluorescein
angiography. Nathaniel Sears, S. K. Srivastava, K.
Baynes, C. Y. Lowder, J. Ehlers, R. Rennebohm.
Cleveland Clinic Foundation, Cleveland, OH
3835 — C0137 Response and dependence to
the induction therapy of intravitreal aflibercept
in AMD. Noriko Miyamoto1, 2, M. Mandai1, 3,
M. Shimozono1, 2, T. Kameda1, 2, A. Nishida1, 2,
Y. Kurimoto1, 2. 1Dept of Ophthalmology, Kobe
City Med Ctr Gen Hosp, Kobe, Japan; 2Dept of
Ophthalmology, Institute of Biomedical Research
and Innovation Hospital, Kobe, Japan; 3Laboratory
for Retinal Regeneration, RIKEN Center for
Developmental Biology, Kobe, Japan *CR
3836 — C0138 Efficacy Of Aflibercept In
Japanese Patients With Polypoidal Choroidal
Vasculopathy Insensitive To Ranibizumab
Treatment. Toshiaki Hirakata1, 2, Y. Nishikawa1, 2,
K. Fujinami2, 3, K. Watanabe1, 2, K. Tsunoda1, 2,
T. Noda1, 2, K. Akiyama1, 2. 1Ophtalmology,
National Hospital Organization, Tokyo Medica
Center, Meguro-ku, Japan; 2Laboratory of Visual
Physiology, National Institute of Sensory Organs,
National Tokyo Medical Center, Meguro-ku,
Japan; 3Ophthalmology, Keio University, School of
Medicine, Shinjyuku-ku, Japan
3837 — C0139 En face enhanced depth imaging
optical coherence tomography of polypoidal
choroidal vasculopathy. Oudy Semoun, F. Coscas,
G. J. Coscas, E. H. Souied. Ophthalmology, Creteil
University Eye Clinic, Creteil, France
3838 — C0140 Results of variable-dosing
schedule with ranibizumab therapy in
neovascular age-related macular degeneration
in a clinical setting. Michela Vinci, L. Porcu, M.
Fossarello. Ophthalmology, University of Cagliari,
Cagliari, Italy
3839 — C0141 Six-month results of
switching to aflibercept for polypoidal
choroidal vasculopathy in patients refractory
to ranibizumab. Takeya Kohno1, M.
Yamamoto1, A. Cho2, Y. Yoshida1, H. Iwami1,
Y. Sawa1, K. Yoshimoto1, M. Hirabayashi2, K.
Shiraki1. 1Ophthalmology & Visual Science,
Osaka City Univ Grad Sch of Med, Osaka,
Japan; 2Ophthalmology, Shiraniwa Hospital, Ikoma,
Japan
3840 — C0142 Automatic Quantification of
RPE Layer Thickness Using a Gaussian Curve
Fitting Method in OCT. Shu-Wei Sun1, 2, C.
Chung1, H. Liang1. 1Loma Linda University, Loma
Linda, CA; 2University of California, Riverside, CA
3841 — C0143 Near-infrared fundus
autofluorescence in retinal pigment epithelium
tear. Tetsuya Yamagishi1, N. Terao1, T. Yamazaki1,
H. Koizumi2, S. Kinoshita1. 1Department of
Ophthalmology, Kyoto Prefectural Univ of Med,
Kyoto, Japan; 2Department of Ophthalmology,
Tokyo Women, Tokyo, Japan
3842 — C0144 Retinal ganglion cell loss
and optic nerve changes in mice at two
weeks and eight months post repeated
traumatic brain injury. Radouil T. Tzekov1, 2,
M. Gautier1, B. Mouzon1, J. Ojo1, D. Biggins1,
F. Crawford1, 2. 1Roskamp Institute, Sarasota,
FL; 2James A Haley Veterans’ Hospital, Tampa, FL
3843 — C0145 Preoperative Predictive
Factor of Retinal Pigment Epithelium Tear
after treatment of eyes with Age-Related
Macular Degeneration Associated with Large
Vascularized Retinal Pigment Epithelium
Detachment. Hisashi Matsubara, K. Matsunaga, R.
Miyata, Y. Matsui, M. Kondo. Ophthalmology, Mie
Univ Grad School of Medicine, Tsu, Japan
3844 — C0146 Quantitation of Hyperspectral
Autofluorescence (AF) from Human Retinal
Pigment Epithelium (RPE) Ex Vivo. Camellia
Nabati1, A. Johri1, R. Post1, P. Sajda3, T. Ach2, C.
A. Curcio2, T. Smith1. 1Ophthalmology, NYU,
New York, NY; 2Ophthalmology, The University
of Alabama at Birmingham, BIRMINGHAM,
AL; 3Biomedical Engineering, Columbia University,
New York, NY
3845 — C0147 Hyperspectral image analysis
of ex vivo autofluorescence (AF) of human
Bruch’s membrane (BrM). Aalya Fatoo1, A.
Johri1, R. Post1, P. Sajda1, C. A. Curcio2, T. Ach2, T.
Smith1. 1Ophthalmology, NYU School of Medicine,
New York, NY; 2Opthalmology, University of
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Retina
381 Endophthalmitis and trauma
Moderator: Harry W. Flynn
3846 — C0148 Demographics, Characteristics,
Interventions, and Outcomes of Eyes with
Open Globe Injuries with Intraocular Foreign
Bodies. Sarah M. Abbassi2, 3, P. Misra2, 3, A.
Bauza2, 3, M. Zarbin1, 3, N. Bhagat1, 3. 1Institute of
Ophthalmology and Visual Sciences, Newark,
NJ; 2Rutgers, New Jersey Medical School, Newark,
NJ; 3Rutgers, The State University of New Jersey,
Newark, NJ
3847 — C0149 Increased Risk of PostCataract Endophthalmitis in Uveitis Patients - A
Retrospective 10 Year Study. Cecilia S. Lee, E.
Carreno, G. Fernandez Sanz, A. Y. Lee, C. Nemeth,
C. Cook, R. Dattani, R. W. Lee, C. E. Pavesio.
Moorfields Eye Hospital, London, United Kingdom
3848 — C0150 Open globe injuries caused by
elastic cords: A 13 year retrospective review. Luis
G. Leon, N. Bhagat, A. Bauza. Institute of
ophthalmology and visual sciences, Rutgers- New
3849 — C0151 Open Globe Injuries With
Positive Intraocular Cultures, 2000 To 2012: A
Case Series. Ryan C. Young, D. W. Parke, H. Aziz,
H. W. Flynn. Ophthalmology, Bascom Palmer Eye
Institute, Miami, FL
3850 — C0152 The Comparison of Regional
versus General Anesthesia for Surgical Repair of
Open Globe Injuries. Andrew J. McClellan1, J. J.
Daubert2, H. W. Flynn1, S. Gayer1. 1Bascom Palmer
Eye Institute, Miami, FL; 2University of Miami
School of Medicine, Miami, FL
3851 — C0153 Prospective study on
antimicrobial resistance rates following repeated
courses of topical antibiotics for intravitreal
injection. Tahia Haque, T. Kirn, D. B. Roth, S. P.
Shah, D. L. Yarian, H. F. Fine. NJ Retina, Rutgers
University Medicine and Dentistry of NJ, New
Brunswick, NJ *CR
3852 — C0154 Determining the Effect of
Antibiotic Drop Prophylaxis Post Lucentis
Injection on the Conjunctival Flora. Dustin
Curts, P. Hooper. Ivey Eye Institute, London, ON,
Canada f
266
3853 — C0155 A Prospective And Nationwide
Study Investigating Endophthalmitis Following
Pars Plana Vitrectomy: Incidence, Risk
Factors, Clinical Presentation, Microbiology,
Management and Outcome. Jonathan C. Park1, B.
Ramasamy2, S. Shaw3, S. Prasad2, R. Ling2. 1West
of England Eye Unit, Royal Devon and Exeter
Hospital, Exeter, United Kingdom; 2Ophthalmology,
Wirral University Teaching Hospital NHS
Foundation Trust, Wirral, United Kingdom; 3School
of Computing and Mathematics, Plymouth
University, Plymouth, United Kingdom
3854 — C0156 Risk Factors Associated With
Developing Endogenous Endophthalmitis.
Kamyar Vaziri1, S. Pershing2, T. A. Albini1, D. M.
Moshfeghi2, A. A. Moshfeghi1, 3.1Ophthalmology,
Bascom Palmer Eye Insititue, University of Miami,
Miller School of Medicine, Palm Beach Gardens,
FL; 2Ophthalmology, Byers Eye Institute, Standford
University School of Medicine, Palo Alto,
CA; 3Retina Associates of Kentucky, Lexington, KY
3855 — C0157 Intraocular Inflammation
Following Aflibercept (Eylea) Injection. Howard
F. Fine, D. B. Roth, S. P. Shah, T. Haque, H. M.
Wheatley. NJ Retina, Rutgers University Medicine
and Dentistry of NJ, New Brunswick, NJ *CR
3856 — C0158 Endophthalmitis caused
by Klebsiella species. Jayanth Sridhar, H. W.
Flynn, A. E. Kuriyan, S. R. Dubovy, D. Miller.
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL *CR
3858 — C0160 Clinical Relevance of Gram
Positive Endophthalmitis and Antibiotic
Susceptibility. Rebecca Shields, H. W. Flynn,
D. Miller. Ophthalmology, Bascom Palmer Eye
Institute, Miami, FL *CR
3859 — C0161 A Retrospective Case Study
of the Incidence of Endogenous Fungal
Endophthalmitis in Patients with Positive Blood
Cultures for Systemic Fungemia: Review of the
Literature. Katherine Chen, J. Colina, L. Snyder, S.
M. Hariprasad. University of Chicago, Chicago, IL
3861 — C0163 Endophthalmitis after
intravitreal injections, a retrospective study.
Jordan Burnham, S. Duhon, C. J. Chen, H.
Hancock. University of Mississippi Medical Center,
Jackson, MS
3862 — C0164 Etiologies and visual
outcomes of pars plana vitrectomy for
endophthalmitis. William R. Rhoades, S. Ness.
Ophthalmology, Boston University, Boston, MA
3863 — C0165 Histopathology of enucleation
specimens of fungal endophthalmitis secondary
to a compounding pharmacy. Fadi S. Shaya1, T.
J. Walsh3, K. W. Small1, D. Minckler2. 1Macula &
Retina Institute, Glendale, CA; 2Ophthalmology
and Laboratory Medicine, University of California,
Irvine, Irvine, CA; 3Pediatrics and Microbiology
and Immunology, Weill Cornell Medical College,
New York, NY
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Retina / Multidisciplinary Ophthalmic Imaging /
Physiology/Pharmacology / Retinal Cell Biology
382 Retinal and choroidal
vascular diseases
3864 — C0166 Frequency of Anti-VEGF
Injections in Retinal Vein Occlusions. Cajal Patel,
R. N. Frank. Ophthalmology, Kresge Eye Institute,
Detroit, MI
3865 — C0167 : En Face OCT Patterns of
choriocapillaris and of different choroidal
vascular layers and their changes in active
polypoidal choroidal vasculopathy. Gabriel J.
Coscas, F. Coscas, A. Dirani, O. Semoun, E. H.
Souied. Department of Ophthalmology, Creteil Eye
Clinic Univ Hospital, Creteil, France *CR
3866 — C0168 Short-term efficacy of single
ranibizumab injection in Japanese patients with
macular edema secondary to branch retinal
vein occlusion; a comparison between treatment
naïve cases and patients with past treatment.
Akira Ojima, T. Sekiryu, M. Saito, Y. Oguchi, M.
Ogasawara, R. Tomita. Ophthalmology, Fukushima
Medical University, Fukushima, Japan
3867 — C0169 Spectral-Domain Optical
Coherence Tomographic Finding of Macular
Edema Associated with Central Retinal Vein
Occlusion as a Predictor of Response to
Bevacizumab. JIhwan Lee1, Y. Park1, S. Byeon1, S.
Lee1, C. S. Lee1, Y. You2, S. Kim1. 1Ophthalmology,
Institute of Vision Research, Department of
Ophthalmology, Yonsei University College of
Medicine, Seoul, Republic of Korea; 2Nune Eye
Hospital, Seoul, Republic of Korea
3868 — C0170 Treatment of retinal vein
occlusions: intravitreal dexamethasone implant
versus intravitreal bevacizumab 12 months
outcomes. Zoya Hameed1, D. Jivah1, U. Janjua2, G.
Ansari1, M. Chandran1, G. Menon1. 1Eye Treatment
Centre, Frimley Park Hospital, Frimley, United
Kingdom; 2Queen Elizabeth Hospital, Birmingham,
United Kingdom *CR
3869 — C0171 Intravitreal Activated Protein
C Injection As A Novel Treatment For Ischemic
Central Retinal Vein Occlusion.Motohiro Kamei,
S. Sakimoto, N. Matsumura, M. Suzuki, H.
Sakaguchi, K. Nishida. Ophthalmology, Osaka Univ
Grad School of Medicine, Suita, Japan f
3870 — C0172 Relationship between retinal
venous tortuosity and aqueous vascular
endothelial growth factor concentration in eyes
with central retinal vein occlusion.Shunsuke
Yasuda1, S. Kachi1, M. Kondo2, Y. Tamai1, S.
Ueno1, H. Terasaki1. 1Ophthalmology, Nagoya
Japan; 2Ophthalmology, Mie University Graduate
School of Medicine, Tsu, Japan
3871 — C0173 In vivo microscopy using
adaptive optics scanning light ophthalmoscope
fluorescein angiography and analysis of the
foveal microvasculature in sickle cell retinopathy
and comparison with SD-OCT. Alexander Gan1,
N. Shah1, M. M. Razeen1, A. Pinhas1, 2, E. Cheang1, 3,
R. Weitz1, R. Gentile1, 6, A. Dubra4, 5, T. Y. Chui1, R.
B. Rosen1.1Departments of Ophthalmology, New
York Eye and Ear Infirmary, Mount Sinai Health
System and New York Medical College, New York,
NY; 2Icahn School of Medicine at Mount Sinai,
New York, NY; 3Stuyvesant High School, New
York, NY; 4Department of Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 5Department
of Biophysics, Medical College of Wisconsin,
Milwaukee, WI; 6Department of Ophthalmology,
Winthrop University Hospital, Mineola, NY *CR
3872 — C0174 Maculopathy in sickle cell
disease : about a macular degeneration in
caribbean people. Edel Finke1, S. Chahed3, C.
Mehanna2, M. Etienne-Julan5, N. Lemonne5, P.
Connes4, T. David1. 1Ophthalmology, University
Hospital, Gosier, France; 2Ophthalmology, HotelDieu, Paris, France; 3Ophthalmology, Lariboisiere,
PARIS, France;4INSERM, Pointe-à-Pître/ Abymes,
France; 5Centre intégré de la drépanocytose, Pointeà-Pître/ Abymes, France
267
Tuesday Posters
3:45 pm – 5:30 pm
3857 — C0159 Endophthalmitis rates and
clinical features following intravitreal antivascular endothelial growth factor injections
for diabetic eye disease versus neovascular
age-related macular degeneration and retinal
vein occlusion. Nadim Rayess1, 4, E. Rahimy1, 4,
M. Dollin1, 4, P. Storey1, 4, S. Garg1, 4, C. Shah2, J.
Wolfe3, J. Hsu1, 4. 1Wills Eye Hospital, Philadelphia,
PA; 2Ophthalmic Consultants of Boston, Boston,
MA; 3Associated Retinal Consultants at William
Beaumont Hospital, Royal Oak, MI; 4Mid Atlantic
Retina, Plymouth Meeting, PA
3860 — C0162 Inpatient Ophthalmology
Consultation for Fungemia: Prevalence
of Ocular Involvement and Necessity of
Funduscopic Screening. Megan Nichols1, S.
Vahedi1, M. K. Adam2, R. E. Fintelmann4, J. D.
Keenan3, S. Garg2, J. Hsu2, M. Spirn2. 1Jefferson
Medical College, Philadelphia, PA; 2Retina Service,
Wills Eye Hospital at Thomas Jefferson University,
Philadelphia, PA; 3Francis I. Proctor Foundation
and Department of Ophthalmology, University
of California, San Francisco, San Francisco,
CA; 4Barnet Dulaney Perkins Eye Center,
Phoenix, AZ
3873– 3896 – Tuesday – Posters
3873 — C0175 Spectral domain optical
coherence tomography measurements of macular
thickness in sickle cell disease: comparison
between HbSS and HbSC genotypes. Moin
Mohamed, T. Magan, M. Robertson, O. A. Mahroo.
Ophthalmology, St Thomas› Hospital, London,
United Kingdom
3874 — C0176 Correlation between Age of
onset and number of ranibizumab injections
required in patients with wet Age related
Macular Degeneration. Kanupriya M. Darrad,
N. Narendran, Y. C. Yang, S. Lee. Ophthalmology,
Wolverhampton eye infirmary, Wolverhampton,
United Kingdom *CR
3875 — C0177 Retinal detachment from
retinal dialysis managed by scleral buckling
surgery. Jonathan S. Chang, H. W. Flynn, A. M.
Berrocal. Ophthalmology, Bascom Palmer Eye
Institute, Miami, FL
3876 — C0178 Current Management and
Barriers to Treatment for Wet Age-related
Macular Degeneration: Perspectives From
Patients and Caregivers. Monica Varano.
Fondazione G.B. Bietti-IRCCS, Rome, Italy *CR
Tuesday Posters
3:45 pm – 5:30 pm
3877 — C0179 Correlation between changes
of retinal and choroidal thickness and blood
flow after intravitreal bevacizumab for macular
edema secondary to branch retinal vein
occlusion. Marie Fukami, T. Iwase, S. Yasuda, K.
Yamamoto, K. Yanagida, T. Hatano, Y. Tamai, H.
Terasaki. ophthalmology, Nagoya University School
of Medicine, Nagoya, Japan
3878 — C0180 Outcome of Intravitreal
Dexamethasone Implant in Retinal Vein
Occlusion Using As-required Retreatment
Regimen. Ying Lucia Dong, M. Elgohary, M.
Syrimi, V. Sivagnanavel. The Royal Eye Unit,
Kingston Hospital, Kingston-Upon-Thames, United
Kingdom *CR
3879 — C0181 Retinal vein occlusion :
morphological study of retinal veins in SDOCT and its correlations with clinical and
angiographic findings. Elsa Bruyere, A. GlacetBernard, A. Georges, C. J. Kamami-Levy, O.
Rostaqui, G. Querques, E. H. Souied. Centre
Hospitalier Intercommunal de Creteil, Créteil,
France
3880 — C0182 VESGEN analysis of human
macular microvasculature in venous occlusive
disease imaged in vivo with AOSLO FA. Patricia
A. Parsons-Wingerter1, A. Pinhas2, 3, M. Dubow2, 3,
N. Shah2, A. Gan2, M. M. Razeen2, T. Y. Chui2, R.
B. Rosen2, 4. 1Research and Technology Directorate,
John Glenn NASA Research Center, Cleveland,
OH; 2Department of Ophthalmology, New York
Eye and Ear Infirmary, New York, NY; 3Icahn
School of Medicine at Mount Sinai, New York, NY;
4
Department of Ophthalmology, New York Medical
College, New York, NY *CR
3881 — C0183 Evaluation of outer retina folds
in patients with macula off rhegmatogenous
retinal detachment. Enrico Peiretti1, 2, A. Willig2,
S. Lesnik2, H. Bijl2, M. Mura2.1Odontostomatol &
Surgical Science, University Eye Clinic of Cagliari,
Cagliari, Italy; 2Vitreo-Retinal Department,
Academic Medical Center, University of
Amsterdam, Amsterdam, Netherlands
3889 — C0191 Effect of Alternate
Ranibizumab Dosing Regimens on Visual
and Anatomic Outcomes in Patients with
Retinal Vein Occlusion - The SHORE
study. Seenu M. Hariprasad1, L. Yau2, G.
Sternberg2. 1Ophthalmology, University of Chicago,
Chicago, IL; 2Genentech, Inc, South San Francisco,
CA *CR, f
3882 — C0184 Short-Term Results of
Intravitreal Aflibercept Injections for Patients
with Polypoidal Choroidal Vasculopathy. Mio
Hosokawa1, A. Yamashita2, C. Shiragami2, A.
Ono2, M. Kobayashi2, Y. Shirakata2, S. Kimura1,
A. Fujiwara1, Y. Morizane1, F. Shiraga1. 1Okayama
university Hospital, Okayama city, Japan; 2Kagawa
Univercity, Miki-cho, Japan *CR
3890 — C0192 Ozurdex Outcomes in Retinal
Vein Occlusion (RVO) with Macular Oedema
(MO). Valerie Juniat, E. Tsolakou, N. Patel.
Kent & Canterbury Hospital, Canterbury, United
Kingdom *CR
3883 — C0185 Reduced-fluence photodynamic
therapy in polypoidal choroidal vasculopathy
patients non-responding to ranibizumab. Ik Soo
Byon1, 2, S. Park3, J. E. Lee3, 4.1Ophthalmology,
Pusan National University Yangsan Hospital,
Yangsan-si, Republic of Korea; 2Research
Institute for Convergence of Biomedical
Science and Technology, Yangsan, Republic of
Korea; 3Ophthalmology, Pusan National University
Hospital, Busan, Republic of Korea; 4Medical
institute, School of medicine, Pusan National
University, Pusan, Republic of Korea
3884 — C0186 Individualized Ranibizumab
Monotherapy Strategies During 3 After
As-Needed Treatment Based On Monthly
Examinations For Polypoidal Choroidal
Vasculopathy. Taiichi Hikichi, H. Kitamei, S.
Shioya. Ohtsuka Eye Hospital, Sapporo, Japan
3885 — C0187 Early effects of dexamethasone
erodible implant on macular edema due to
retinal vein occlusion: retinal morphology and
visual function. Daniele Veritti, S. Macor, P.
Lanzetta. Department of Ophthalmology, University
of Udine, Udine, Italy *CR
3886 — C0188 Mechanisms of Visual Function
Loss in Proliferative Diabetic Retinopathy. Grace
Boynton1, M. Stem1, G. R. Jackson2, T. W.
Gardner1. 1Ophthalmology and Visual Sciences,
Kellogg Eye Center, University of Michigan, Ann
Arbor, MI; 2Ophthalmology, Penn State Hershey
Eye Center, Penn State College of Medicine,
Hershey, PA *CR
3887 — C0189 The factors affect repetitive
injections of intravitreal Bevacizumab in patients
with branch retinal vein occlusion. Kyung Tae
Kang, Y. Kim, K. Kim. Ophthalmology, Dong San
Medical Center, Keimyung University, Daegu,
Republic of Korea
3888 — C0190 Intravitreal Ranibizumab in
daily clinical practice for age-related macular
degeneration. Julien Gozlan, A. Cazet-Supervielle,
S. Rouissi, C. De Beketch, M. Boissonnot, N.
Leveziel. Ophthalmology, University Hospital of
Poitiers, Poitiers, France
3891 — C0193 Intravitreal Anti-Vascular
Endothelial Growth Factor for Treating
Polypoidal Choroidal Vasculopathy with Grapelike Polyp Cluster. Young Ju Lew, J. Han, H. Cho,
J. Kim. Ophthalmology, Kim›s Eye Hospital, Seoul,
Republic of Korea
3892 — C0194 Correlation between foveal
ischemia and spectral-domain optical
coherence tomography findings in retinal vein
occlusion. Ravi Keshavamurthy, S. Grover, K.
Chalam. Ophthalmology, University of Florida Eye
Institute, Jacksonville, FL
3893 — C0195 Microvascular changes
following low dose focal radiotherapy
for neovascular age-related macular
degeneration. Barbra Hamill1, K. A. Muldrew1,
M. J. Quinn1, J. S. Slakter2, D. O’Shaughnessy2,
A. Czeszynski2, U. Chakravarthy1, 2. 1Centre for
Experimental Medicine, Queens University Belfast,
Belfast, United Kingdom; 2Oraya Therapeutics Inc,
Newark, NJ *CR
3894 — C0196 A Prospective Pilot Study of
the Effects of Panretinal Photocoagulation
Delivered with a Multi-spot Laser on Retinal
Sensitivity and Driving Eligibility in Patients
with Diabetic Retinopathy. Mala Subash1, A.
Samy1, D. Qatarneh1, S. Antonakis1, G. Liew1, V.
Mccudden1, R. G. Weleber2, T. Peto1, L. Wickham1,
M. Michaelides1. 1Medical Retina Department,
Moorfields Eye Hospital, London, United
Kingdom; 2Ophthalmollogy and Molecular Medical
Genetics, Casey Eye Institute OHSU, Portland,
OR *CR, f
3895 — C0197 Electroretinographic findings
after Intravitreal Ranibizumab and Single
or Multiple Spot Panphotocoagulation in
Proliferative Diabetic Retinopathy - 6 Months
Results. Carina C. Cotrim, R. Jorge, A. Messias,
K. Messias, R. Barroso. Ophthalmology, Ribeirão
Preto Medical School, University of São Paulo,
Ribeirão Preto, Brazil f
3896 — C0198 Effect of Pan Retinal
Photocoagulation on Anterior Chamber
Depth and Volume: A Model for Evaluation of
Choroidal Microeffusion. Justin Rome, S. Reich,
E. Brodbaker, P. S. Rosenbaum, J. Levine, N.
Nataneli. Ophthalmology, Bronx Lebanon Hospital
Center, Albert Einstein College of Medicine,
Bronx, NY
268
3897 — C0199 Variation in retinal oxygenation,
retinal vasculature, and retinal nerve fiber layer
thickness in patients with different grades of
diabetic retinopathy. Shamira Perera1, 2, A. Mohla1,
M. E. Nongpiur2, C. Y. Cheung2, N. Milastuti4, V.
Foo3, R. Mathur1. 1Glaucoma, Singapore National
Eye Centre, Sinagpore, Singapore; 2Singapore Eye
Research Institute, Singapore, Singapore; 3YLL
Medical School, National University of Singapore,
Singapore, Singapore; 4Gadjah Mada University,
Yogyakarta, Indonesia
3898 — C0200 Choroidal Thickness in
Acute and Longstanding Branch Retinal Vein
Occlusion. Sukjin Kim, K. Kim. Department of
Ophthalmololgy, Saevit Eye Hospital, Goyang City,
Republic of Korea
3899 — C0201 Retinal reperfusion following
panretinal photocoagulation for diabetic
retinopathy. Tsuneaki Omae, T. Nagaoka, A.
Yoshida. Ophthalmology, Asahikawa Medical
College, Asahikawa, Japan
3900 — C0202 Panretinal
photocoagulation(PRP) versus Intravitreal
bevacizumab plus PRP for diabetic retinopathy.
Jeongjae Oh, S. Kim, K. Kim. Department of
Ophthalmology, Saevit Eye Hospital, Goyang City,
Republic of Korea
3902 — C0204 The effects of panretinal
photocoagulation on retinal nerve fiber layer at
the optic nerve head. Aditi Mohla1, 2, R. Mathur1,
M. E. Nongpiur2, C. Y. Cheung2, N. Milastuti4,
V. Foo3, S. Perera1, 2. 1Singapore National Eye
Centre, Singapore, Singapore; 2Singapore Eye
Research Institute, Singapore, Singapore; 3YLL
Medical School, National University of Singapore,
Singapore, Singapore; 4Gadjah Mada University,
Yogyakarta, Indonesia
3903 — C0205 Evaluation of the efficacy
of ranibizumab for the treatment of diabetic
macular edema in daily practice. Ali Erginay1,
R. Hage1, M. El Sanharawi2, B. Dupas1, J. Jacob1,
P. Massin1. 1Ophthalmology, Hopital Lariboisiere,
Paris, France; 2UMRS 872, Team 17, Inserm, Paris,
France *CR
3904 — C0206 PASCAL panretinal
photocoagulation (PRP) versus ETDRS PRP
associated with intravitreal Ranibizumab
(IVR) versus only IVR for proliferative diabetic
retinopathy. Rafael de Montier Barroso, A.
Messias, R. Jorge. Ophthalmology, Ribeirão Preto
Medical School, University of São Paulo, Ribeirão
Preto, Brazil f
3906 — C0208 High altitude related vitreous
hemorrhage after panretinal photocoagulation
(PRP) for retinal neovascularization. Felina
Kremer, S. Rashid. Ophthalmology, Montefiore
Medical Center - Albert Einstein College of
Medicine, Bronx, NY
3907 — C0209 Evaluation Of Retinal Blood
Flow Velocity Profiles Using Spectral-Domain
Doppler Optical Coherence Tomography In
Healthy Subjects. Taiji Nagaoka, T. Tani, A.
Ishibazawa, S. Nakabayashi, T. Omae, K. Sogawa,
A. Yoshida. Ophthalmology, Asahikawa Medical
University, Asahikawa, Japan
3908 — C0210 Effect of Panretinal
Photocoagulation on Ocular Amyloidosis
Associated with Transthyretin related-Familial
Amyloidotic Polyneuropathy. Daisuke Eiki1, T.
Kawaji1, Y. Ando2, H. Tanihara1. 1Department of
Ophthalmology, Kumamoto University, Kumamoto,
Japan; 2Department of Neurology, Kumamoto
University, Kumamoto, Japan
3909 — C0211 Clinical experience on
intravitreal ranibizumab for DME on a reallife. Giulia Airaghi, S. Donati, S. Caprani, C.
Gandolfi, L. Premoli, S. Battistini, M. Chiaravalli,
C. Azzolini. Dept. of Surgical and Morphological
Sciences - Section of Ophthalmology, University of
Insubria, Varese, Italy
3910 — C0212 Choroidal Thickness
in Polypoidal Choroidal Vasculopathy
After Switching to Intravitreal Aflibercept
Injection. Shigeyuki Ise, M. Saito, Y. Sugano, A.
Ojima, T. Sekiryu. Fukushima Medical University
School of Medicine, Fukushima, Japan
3911 — C0213 Intravitreal Bevacizumab
vs. Dexamethasone implant in Retinal Vein
Occlusion: a Crossover Study. Andreas
Karydis1, E. H. Shao1, 2, M. K. Gemenetzi1, S. R.
Taylor1, 2. 1Ophthalmology, Royal Surrey County
Hospital, Guildford, United Kingdom; 2Faculty
of Medicine, Imperial College London, London,
United Kingdom
3912 — C0214 Twelve-month results of
treatment with intravitreal ranibizumab,
intravitreal ranibizumab plus ketorolac eye
drops, and intravitreal ranibizumab plus lowfluence photodynamic therapy for exudative
age-related macular degeneration. Andrea Russo1,
C. Costagliola2, L. Delcassi1, M. R. Romano3, R.
Turano1, F. Semeraro1. 1Department of Neurological
and Vision Sciences, University of Brescia, Brescia,
Italy; 2Department of Health Sciences, Eye Clinic,
University of Molise, Campobasso, Italy; 3Eye
Clinic, Istituto Clinico Humanitas, Milano, Italy f
3913 — C0215 United Kingdom national
database study of intravitreal dexamethasone
implant (Ozurdex®) for retinal vein occlusion
related macular oedema. Patients’ pre-treatment
characteristics and treatment procedure. Ahmed
A. Sallam1, J. Zarranz-Ventura1, 2, Q. Mohamed1, R.
Johnston1. 1Ophthalmology, Cheltenham General
Hospital, Cheltenham, United Kingdom; 2Bristol
Eye Hospital, Bristol, United Kingdom *CR
3914 — C0216 Assesment of patients treated
with ranibizumab for retinal vein occlusion
(RVO). Efi Karakosta1, 2, A. Vachtsevanos1, 2, M.
Choulidou1, A. Vasilopoulou1, L. Kazantzidis1,
D. Tsakpinis1, A. Polychronakos1. 1Eye Clinic “O
Agios Dimitrios” General Hospital, Thessaloniki,
Greece; 2OPHTHALMICA Eye Clinic,
Thessaloniki, Greece
3915 — C0217 Polypoidal choroidal
vasculopathy - is indocyanine green angiography
essential for diagnosis? Inês Laíns1, J. Figueira1, 2,
C. Farinha1, M. Cachulo1, 2, M. Costa2, A. Santos2, P.
Melo2, R. Silva1, 2. 1Department of Ophthalmology,
Centro Hospitalar e Universitário de Coimbra,
Coimbra, Portugal; 2Association for Innovation and
Biomedical Research on Light and Image, Coimbra,
Portugal *CR
3916 — C0218 Effects of Macular Ischemia
and Early Treatment on Visual Outcome in
Branch Retinal Vein Occlusion. Jung Bin Han, K.
Seo, S. Yu, H. Kwak. Ophthalmology, Kyung Hee
3917 — C0219 Aqueous VEGF levels in
Retinal Vascular Occlusion (RVO) before and
after Intravitreal injection of Bevacizumab
Correlate with Visual Acuity and Macular
Thickness. Shamim A. Haji, S. Grover, B.
Sankarathi, K. V. Chalam. Ophthalmology, UF
College of Medicine-Jacksonville, Jacksonville, FL
3918 — C0220 Long Term Efficacy of
Intravitreal Bevacizumab for Macular Edema
Secondary to Retinal Vein Occlusions. Xining He,
M. Elia, E. Hsieh, R. A. Adelman. Ophthalmology,
Yale University School of Medicine, New Haven,
CT
3919 — C0221 Real-World Vision
Outcomes in RVO Treated With Anti-VEGF
Injections- An Analysis of EMR Data From
a Large Health System. Hitesh Chandwani1,
A. L. Cole2, J. Campbell1, H. Ingraham3, A.
Almony4, S. Kiss5, S. Marks3, J. W. Kowalski1,
N. M. Holekamp6, 7. 1GHOSR, Allergan, Inc.,
Irvine, CA; 2CHDA, Allergan, Inc., Irvine,
CA;3Opthalmology, Geisinger Health System,
Danville, PA; 4Ophthalmology, Carolina Eye
Associates, Southern Pines, NC; 5Ophthalmology,
NY; 6The Pepose Vision Institute, Chesterfield,
MO; 7Ophthalmology, Washington University
School of Medicine, St. Louis, MO *CR
269
Tuesday Posters
3:45 pm – 5:30 pm
3901 — C0203 Intravitreal Dexamethasone
Implant for Macular Edema Secondary to
Retinal Vein Occlusion that is Refractory
to Intravitreal Anti-VEGF compared to
treatment naïve Edema. Amelie Pielen1, 2, D.
Böhringer2, S. U. Heinzelmann2, T. Ness2, B.
Junker1, 2. 1Ophthalmology, Medical School of
Hanover, Hannover, Germany; 2Eye Centre, AlbertLudwigs-University, Freiburg, Germany *CR
3905 — C0207 Intravitreal triamcinolone
acetonide with anti-VEGF therapy for
the management of polypoidal choroidal
vasculopathy. Gisela Velez. 1Central Massachusetts
Retina and Uveitis Center, Worcester, MA;
2
Ophthalmology, Univ of Massachusetts Med
School, Worcester, MA *CR
3920 — C0222 Medical practices overview in
wAMD in France. Benjamin Wolff1, A. Bourhis2, P.
Cornut3, V. Gualino4, H. Massé5, G. Souteyrand6, M.
Streho7, S. Tick8, J. Zerbib9, C. Chartier10. 1Professor
Sahel Dept, Fondation De Rothschild, Paris,
France; 2Atlantique Polyclinic, Nantes, France; 3Val
d’ouest Clinic, Ecully, France; 4Honoré Cave Clinic,
Montauban, France; 5Nantes Hospital, Nantes,
France; 6Nancy Hospital, Nancy, France; 7Explore
Vision, Rueil Malmaison, France; 8Professor Sahel
Dept, XV XX Hospital, Paris, France; 9Créteil
Hospital, Créteil, France; 10Novartis, Rueil
Malmaison, France *CR
3925 — C0227 Retrospective Review of
Lucentis “Treat and Extend” Patterns and
Outcomes in Age-Related Macular Degeneration.
Yufeng N. Chen2, A. Powell1, A. Mao1, T. G.
Sheidow1. 1Ophthalmology, Ivey Eye Institute,
London, ON, Canada; 2Schulich School of Medicine
and Dentistry, London, ON, Canada *CR
3927 — C0229 Six-Month Outcomes of
Aflibercept in Recurrent or Persistent
Neovascular Age-Related Macular Degeneration.
Cheryl A. Arcinue, F. Ma, G. Barteselli, L.
Sharpsten, A. Doede, M. Gomez, W. R. Freeman.
Retina and Vitreous, University of California San
Diego Shiley Eye Ctr, La Jolla, CA *CR
Tuesday, May 06, 2014 3:45 PM-5:30 PM
Retina
383 CNV Management
Moderator: Robert L. Avery
Tuesday Posters
3:45 pm – 5:30 pm
3921 — C0223 Histamine Receptor H4
as a New Therapeutic Target for Choroidal
Neovascularization in Age-related Macular
Degeneration. Fuxiang Ye1, H. Kaneko1, R.
Ijima1, S. Kachi1, S. Kato2, M. Nagaya1, A.
Higuchi1, H. Terasaki1. 1Ophthalmology, Nagoya
Japan; 2Pathology and Laboratory Medicine,
Nagoya University Hospital, Nagoya, Japan
3922 — C0224 Incidence of Sustained Ocular
Hypertension Using Prepackaged Versus
Freshly-Prepared Intravitreal Bevacizumab
for the Treatment of Neovascular AMD.Vincent
Y. Ho1, P. Storey2, S. Yeh1, G. B. Hubbard1, M.
Fineman2, S. Garg2, S. Reddy2, N. H. Fang-Yen2,
E. Pequingnot2, J. Hsu2. 1Ophthalmology, Emory
Eye Center, Atlanta, GA;2Ophthalmology, Wills,
Philadelphia, PA *CR
3923 — C0225 Intravitreal Aflibercept for
the treatment of Choroidal Neovascularization
(CNV) secondary to Presumed Ocular
Histoplasmosis Syndrome (POHS): Shortterm Results From the HANDLE Study. Brian
Toussaint1, D. M. Marcus3, D. Miller1, J. W.
Kitchens2, H. Singh3, R. Foster1, M. R. Petersen1,
R. Sisk1, C. Riemann1. 1Retina, Cincinnati Eye
Institute/University of Cincinnati, Cincinnati,
OH; 2Retina, Retina Associates of Kentucky,
Lexington, KY; 3Retina, Southeast Retina Center,
August, GA *CR, f
3924 — C0226 Retinal Morphology Changes
Following Intravitreal Aflibercept for TreatmentResistant Neovascular Age-Related Macular
Degeneration. Geoffrey Broadhead1, 2, T. Hong1,
H. Li1, M. Zhu1, 2, W. Wijeyakumar1, 2, A. A.
Chang1, 2. 1Sydney Institute of Vision Science,
Sydney, NSW, Australia; 2Save Sight Institute,
The University of Sydney, Sydney, NSW,
Australia *CR, f
3926 — C0228 Intravitreal Bevacizumab for
the Treatment of Choroidal Neovascularization
in Vogt-Koyanagi-Harada Disease - A
Prospective Study. Viviane M. Sakata, S. Pimentel,
S. F. Abdallah, E. C. Rodriguez, C. E. Hirata, J. H.
Yamamoto. Ophthalmology, Universidade de São
Paulo, Faculdade de Medicina, São Paulo, Brazil
3928 — C0230 The effect of posterior vitreouse
detachment on intravitreal bevacizumab
therapy for neovascular age-related macular
degeneration. Meira Neudorfer1, 2, O. Eshel2, D.
Zur1, 2, A. Barak1, 2. 1Department of Ophthalmology,
Tel-Aviv Medical Center, Tel Aviv, Israel; 2Sackler
Faculty of Medicine, Tel Aviv, Israel
3929 — C0231 Ranibizumab for exudative agerelated macular degeneration: 5 years followup dropout rate. Elise Boulanger-Scemama,
G. Querques, N. Puche, M. Srour, E. H. Souied.
Ophthalmology, Centre Hospitalier Intercommunal
de Créteil, Créteil, France
3930 — C0232 Efficacy of intravitreal
ranibizumab given bimonthly versus PRN in
patients with neovascular age-related macular
degeneration: 1 year results of a prospective,
randomized clinical trial. Nicolas Feltgen1, S.
Pfeiffer2, A. Goerlitz2, H. Hennig2, M. Bretag1, H.
Neunhöffer1, E. Wetzel1, C. Krüger1, J. Callizo1,
H. Hoerauf1. 1Ophthalmology, University
Hospital, Goettingen, Germany; 2Institut fuer
anwendungsorientierte Forschung, University
Goettingen, Goettingen, Germany *CR, f
3931 — C0233 Treat and Extend regimen
versus Pro Re Nata regimen in a comparative
study of ranibizumab in exudative age-related
macular degeneration: 12 months results.Katja
B. Hatz1, 2, C. Pruente1, 2. 1VISTA Klinik, VISTA
Klinik Binningen, Binningen, Switzerland; 2Dep.
of Opthalmology, Kantonsspital Liestal, Liestal,
Switzerland
3932 — C0234 One Year Results of
an Open-Label Study of the Safety and
Tolerability of Combination Therapy Using
Sustained Release Intravitreal Triamcinolone
Acetonide and Ranibizumab for Treatment of
Subfoveal Neovascular Age Related Macular
Degeneration. Jennifer I. Lim1, M. Niec1, V.
Wong2. 1Ophthal-Eye & Ear Infirm, University of
Illinois, Chicago, IL; 2ICON Bioscience, Sunnyvale,
CA *CR, f
3933 — C0235 Efficacy of Dexamethasone
Intravitreal Implant Treatment in Eyes
Previously Treated with Intravitreal AntiVascular Endothelial Growth Factor Therapies
for Retinal Vein Occlusion. Ankoor R. Shah1, 2, A.
M. Alfaran1, 2, J. Wolfe1, 2. 1Vitreoretinal Surgery,
Associated Retinal Consultants, Royal Oak,
MI; 2Ophthalmology, William Beaumont Hospital,
Royal Oak, MI
3934 — C0236 Impact of Retinal Pigment
Epithelial Elevation at Baseline on Visual
Outcomes in the VIEW Studies. Chirag Shah.
Ophthalmic Consultants of Boston, Boston,
MA *CR, f
3935 — C0237 Switch from aflibercept to
ranibizumab: Up to 2 years follow-up post View2
study. Maddalena Quaranta1, F. Devin2. 1Centre
Ophtalmologique Rabelais, Lyon, France; 2Centre
Monticelli-Paradis. Drs.Devin, Morin, Morel,
Marseille, France
3936 — C0238 Efficacy of Aflibercept
in Refractory Wet Age-Related Macular
Degeneration. Catherine Choi1, L. Zhang2, M.
D. Abramoff2, M. Sonka2, A. Shifera1, C. N.
Kay1.1Ophthalmology, University of Florida,
Gainesville, FL; 2Ophthalmology, University of
Iowa, Iowa City, IA
3937 — C0239 Response of Pigment Epithelial
Detachments following Intravitreal Aflibercept
for Age-Related Macular Degeneration. Thomas
Hong1, 2, G. Broadhead1, 2, M. Zhu1, 2, H.
Li1, 2, T. Schlub1, W. Wijeyakumar1, 2, A. A.
Sydney, NSW, Australia; 2Sydney Retina Clinic and
Day Surgery, Sydney, NSW, Australia*CR, f
3938 — C0240 Origin and behavior of Type 3
neovascularization revealed by spectral-domain
optical coherence tomography. Aaron Nagiel1,
K. Freund3, J. J. Jung3, K. Bhavsar3, R. F. Spaide3,
D. Sarraf1, 2. 1UCLA, Los Angeles, CA; 2Kaiser
Permanente, Woodland Hills, CA; 3Vitreous-RetinaMacula Consultants of New York, New York, NY
3939 — C0241 Self-Controlled Comparison
of the Anatomical and Visual Response to
Intravitreal Ranibizumab and Aflibercept in
Treatment-Resistant Age-Related Macular
Degeneration. Andrew A. Chang1, 2, T.
Hong1, 2, G. Broadhead1, 2, N. D. Joachim2, A.
Syed1, 2, T. Schlub2, W. Wijeyakumar1, 2, M.
Zhu2. 1Ophthalmology, Sydney Retina Clinic and
Day Surgery, Sydney, NSW, Australia; 2Sydney
Institute of Vision Science, Sydney, NSW,
Australia *CR, f
3940 — C0242 Analysis of Patients with Wet
Age-related Macular Degeneration (WAMD)
Switched Back to Ranibizumab/Bevacizumab
After a Trial of Aflibercept. Geraldine R. Slean,
R. B. Bhisitkul, D. M. Schwartz, J. M. Stewart.
University of California, San Francisco, San
Francisco, CA
270
3941 — C0243 Parameters Influencing
Clinical Decision Making in Anti-VEGF
Therapy for Neovascular Age-Related Macular
Degeneration. Carly Seidman, K. Yeung, J. J.
Tseng, K. J. Wald. Ophthalmology, New York
University, New York, NY
3942 — C0244 Preliminary results of
aflibercept in treatment naïve choroidal
neovascularization of neovascular agerelated macular degeneration. Sandrine
A. Zweifel, C. Amstutz, J. Fleischhauer, M.
Kurz-Levin, D. Barthelmes. Department of
Ophthalmology, University Hospital Zurich, Zurich,
Switzerland *CR
3949 — C0251 Retinal and choroidal blood
flow changes after switching therapy from
ranibizumab to aflibercept in exudative agerelated macular degeneration. Ai Yoneda, K.
Suzuma, Y. Maekawa, E. Tsuiki, H. Wakiyama,
T. Kitaoka. Ophthalmology and Visual Sciences,
Nagasaki University Graduate School of
Biomedical Sciences, Nagasaki, Japan
3956 — C0258 Changes in Retinal Morphology
in Neovascular Age-related Macular
Degeneration (nAMD) Patients Switched to
Aflibercept. Levente A. Toth1, 2, A. Zykova2,
U. Chakravarthy2, 1. 1Ophthalmology, Belfast
Health and Social Care Trust, Belfast, United
Kingdom; 2Centre for Experimental Medicine,
Queens University, Belfast, United Kingdom *CR
3950 — C0252 Quality of Life in Age-Related
Macular Degeneration Comparing Aflibercept,
Photodynamic Therapy and Pegaptanib Sodium
Treatment Groups. Laura Hall, S. Pakneshan,
R. A. Adelman. Yale Eye Center, Yale University
School of Medicine, Woodbridge, CT
3957 — C0259 A model of 10-year outcomes
of anti-VEGF treatment for neovascular
age-related macular degeneration. Robert
P. Finger1, J. Xie1, Y. Hsueh2, J. Keeffe1, R. H.
Guymer1. 1Ophthalmology, Centre for Eye Research
Australia, Melbourne, VIC, Australia; 2Centre for
Health Policy, School of Population and Global
Health, University of Melbourne, Melbourne, VIC,
Australia
3943 — C0245 Long-term Follow-up of
Intravitreal Aflibercept Injection (IAI) for
Neovascular Age-Related Macular Degeneration
(nAMD) in an Open-Label Extension of the
VIEW1 Study. Dennis M. Marcus. Ophthalmology,
Southeast Retina Center, Augusta, GA *CR, f
3951 — C0253 Ranibizumab (Lucentis) in
neovascular age- related macular degeneration
(AMD): five year follow up. Nadezhda
Cvetkova, D. Maerker, H. Helbig, K. Hoelldobler.
Ophthalmology, University-regensburg,
Ophthalmology, Regensburg, Germany
3944 — C0246 Bimonthly injections
of ranibizumab for age-related macular
degeneration. Tomoko Sawada1, X. Wang1, 2, O.
Sawada1, Y. Saishin1, M. Ohji1. 1Ophthalmology,
Shiga Univ of Med Science, Otsu, Japan; 2The
Key Laboratory of Harbin Medical University Eye
Center, Eye Hospital, First Affiliated Hospital,
Harbin, China *CR, f
3952 — C0254 Conversion to aflibercept
for patients with neovascular age-related
macular degeneration who were refractory
to ranibizumab treatment. Yu Kawashima, A.
Oishi, M. Miyake, M. Yoshikawa, A. Takahashi,
N. Ueda, H. Tamura, K. Yamashiro, A. Tsujikawa,
N. Yoshimura. Department of Ophthalmology and
Visual Sciences, Kyoto University Graduate School
of Medicine, Kyoto, Japan
3946 — C0248 Intravitreal Aflibercept for
Choroidal Neovascularization Due to AgeRelated Macular Degeneration Unresponsive
to Ranibizumab Therapy. Valentina Sarao1, D.
Veritti1, 2, L. Arias3, P. Lanzetta1, 2. 1Department
of Ophthalmology, University of Udine, Udine,
Italy; 2Istituto Europeo di Microchirugia
Oculare - IEMO, Udine, Italy; 3Department of
Ophthalmology, University of Barcelona. Bellvitge
University Hospital, Barcelona, Spain *CR
3947 — C0249 REAL Study :Re-treatment
Evaluated on visual Acuity for Lucentis°. David
Bellocq, F. De Bats, P. Denis, L. Kodjikian.
Ophthalmology, Croix Rousse University Hospital,
Lyon, France *CR
3948 — C0250 Results at Six Months
after Conversion to Aflibercept for Patients
on Prior Ranibizumab or Bevacizumab
Treatment for Exudative Age-Related Macular
Degeneration. Clement K. Chan1, 2, A. Jain3, S. R.
Sadda4, N. Varshney5. 1Southern California Desert
Retina Consultants, Palm Desert, CA; 2Department
of Ophthalmology, Loma Linda University, Loma
Linda, CA; 3San Diego Retina Associates, San
Diego, CA; 4Doheny Image Reading Center,
Doheny Eye Institute, Los Angeles, CA; 5Morris
Eye Group, San Diego, CA *CR
3953 — C0255 Efficacy of Aflibercept
in Treatment-Resistant Exudative Agerelated Macular Degeneration: a Literature
Review. Charles Glass, M. Krzystolik, P. B.
Greenberg. Ophthalmology, Brown University,
Providence, RI
3954 — C0256 Baseline predictors for good
long-term visual outcomes in the treatment
of neovascular AMD with intravitreal antiVEGF therapy. Jesse J. Jung1, 2, C. Y. Chen5, 2,
S. Mrejen2, 4, R. Gallego-Pinazo6, 2, L. Xu7, 2, M.
Marsiglia2, 4, S. Boddu3, 2, K. Freund1, 2. 1Department
of Ophthalmology, Edward S. Harkness Eye
Institute Columbia, New York, NY;2Vitreous
Retina Macula Consultants of NY, New York,
NY; 3Ophthalmology, New York University, New
York, NY; 4LuEsther T. Mertz Retinal Research
Center, Manhattan Eye, Ear and Throat Hospital,
New York, NY; 5Ophthalmology, Monash Health,
Melbourne, VIC, Australia; 6Ophthalmology,
University and Polytechnic Hospital La Fe,
Valencia, Spain; 7Ophthalmology, The New York
Eye and Ear Infirmary, New York, NY *CR
3955 — C0257 Evaluation of imaging
examinations for decision of retreatment
in exudative age related macular
degeneration. Mayer Srour, J. Tilleul, N.
Massamba, F. Ghardaoui, E. Boulanger-Scemama,
F. Lalloum, G. Querques, E. H. Souied. Centre
hospitalier intercommunal de creteil, creteil, France
3959 — C0261 Antiangiogenic efficacy of
intravitreal aflibercept versus ranibizumab in a
fixed and a PRN-guided regimen in the VIEW2
trial. Sebastian M. Waldstein1, C. Simader1, G.
Staurenghi2, M. Larsen4, P. Mitchell3, U. SchmidtErfurth1. 1Christian-Doppler-Laboratory for
Ophthalmic Image Analysis, Vienna Reading
Center, Department of Ophthalmology, Medical
University of Vienna, Vienna, Austria; 2Eye Clinic
- Department of Clinical Science “Luigi Sacco”Sacco Hospital, II School of Ophthalmology,
University of Milan, Milan, Italy; 3Department of
Ophthalmology, University of Sydney, Sydney,
NSW, Australia; 4Department of Ophthalmology,
Glostrup Hospital and National Eye Clinic,
University of Copenhagen, Copenhagen,
Denmark *CR, f
3960 — C0262 Intravitreal Aflibercept in
Neovascular Age-Related Macular Degeneration
and Pigment Epithelial Detachment. Armada
Felix, P. Cidad, N. Pastora, B. Manzano, I. Rosa,
Z. Del Barrio, S. Mediero, M. Capote, O. DAnna.
Hospital La Paz, Madrid, Spain
3961 — C0263 RAVE2 Study : Two
years treatment follow up with intravitreal
ranibizumab (Lucentis®) and verteporfin PDTRF
combination therapy at month 2 for neovascular
age-related macular degeneration (AMD). Marcel
Dominguez, E. Fourmaux, L. Rosier, L. Velasque.
Centre Retine Tourny, Bordeaux, France
3962 — C0264 Intravitreal aflibercept
outcomes in patients with persistent retinal
fluid with prior bevacizumab or ranibizumab
treatment for neovascular age-related macular
degeneration. David Griffin1, P. Richmond2, J.
Olson2. 1University of Central Florida College of
Medicine, Orlando, FL; 2Central Florida Retina and
the Macular Degeneration Center, Orlando, FL
271
Tuesday Posters
3:45 pm – 5:30 pm
3945 — C0247 Changes in Quality of Life
Among Patients Treated with Aflibercept for
neovascular Age-related Macular Degeneration
(nAMD). Wijeyanthy Wijeyakumar1, 2, T.
Hong1, G. Broadhead1, 2, H. Li1, M. Zhu1, 2, A. A.
Sydney, NSW, Australia; 2Save Sight Institute,
The University of Sydney, Sydney, NSW,
Australia *CR, f
3958 — C0260 Quantification Of Change In
Pigment Epithelial Detachment Morphology 18
Months Following Transition To Intravitreal
Aflibercept In Eyes With Recalcitrant
Neovascular Age Related Macular Degeneration.
Aditya Kanesa-thasan, D. S. Grewal, M. Gill,
R. Mirza, A. T. Lyon. Northwestern University,
CHICAGO, IL
3963 — C0265 Low Luminance Visual Acuity
and Treatment Response in Patients with wet
Age-Related Macular Degeneration Enrolled
in the HARBOR Study. Ronald E. Frenkel1, 2, H.
Shapiro3, I. Stoilov3. 1Bascom Palmer Eye Institute,
University of Miami School of Medicine, Miami,
FL; 2Eye Research Foundation and East Florida Eye
Institute, Stuart, FL;3Genentech, Inc., South San
Francisco, CA *CR, f
3964 — C0266 Comparison of functional and
morphological outcome after treatment with
aflibercept or ranibizumab in eyes with chronic
recurrent neovascular age-related macular
degeneration. Andrea E. Hoffmann, N. Feucht, C.
Lohmann, M. M. Maier. Ophthalmology, Klinikum
rechts der Isar, Technische Universität München,
Munich, Germany *CR
Tuesday Posters
3:45 pm – 5:30 pm
3965 — C0267 Baseline Characteristics of the
Fellow Eye in Patients with Wet Age-related
Macular Degeneration: Post-Hoc Analysis of
the VIEW Studies. Jean-Francois Korobelnik1, R.
Morton2, T. A. Katz2, J. S. Slakter3, O. Sowade4,
S. Wolf5. 1Service d, Hopital Pellegrin, Bordeaux,
France; 2Bayer Healthcare Pharmaceuticals,
Whippany, NJ; 3Vitreous-Retina-Macula
Consultants of New York, New York, NY; 4Bayer
Pharma AG, Berlin, Germany; 5Department
of Ophthalmology, University Hospital
Bern, Inselspital, University Bern, Bern,
Switzerland *CR, f
3966 — C0268 Intravitreal Ranibizumab
For Choroidal Neovascularization In Angioid
Streaks: Four Years Follow-Up. Julien Tilleul1,
G. Mimoun2, 1, G. Querques1, N. Puche1, J. Zerbib1,
F. Lalloum1, O. Semoun1, M. Srour1, E. BoulangerScemama1, E. H. Souied1. 1Ophthalmology, Centre
hospitalier intercommunal de Créteil, Créteil,
France; 2Centre Ophtalmologique d’Imagerie de
l’Ecole Militaire, Paris, France *CR
3967 — C0269 Impact of Concomitant
Aqueous Suppressants on PRN Treatment
with Ranibizumab in the 24 Month HARBOR
Study. Mathew MacCumber1, H. Shapiro2, L.
Tuomi2. 1Ophthalmology, Rush University Medical
Center, Chicago, IL; 2Genentech, Inc, South San
Francisco, CA *CR, f
3968 — C0270 Comparison of Treat-andExtend versus As Needed Treatment Protocols
for the Management of Neovascular Age-related
Macular Degeneration. Kelly M. Bui1, M. Krupa2,
M. G. Nittala1, S. R. Sadda1. 1Ophthalmology,
CA; 2University of California, San Diego, San
Diego, CA
3969 — C0271 The EVEN Study: An In-depth
Prospective Trial on Intravitreal Aflibercept
Treatment of Submacular Vascularized
Pigment Epithelial Detachment. Maziar
Lalezary1, D. Sarraf2, P. Abraham3, S. G. Lin1,
C. K. Chan1, 4. 1Southern California Desert
Retina Consultants, Palm Desert, CA; 2Division
of Retinal Disorders and Ophthalmic Genetics,
UCLA Jules Stein Eye Institute, Los Angeles,
CA; 3Black Hills Regional Eye Institute, Rapid City,
SD; 4Ophthalmology, Loma Linda University, Loma
Linda, CA *CR, f
3970 — C0272 Long-Term Visual Outcomes
for a Treat and Extend Anti-VEGF Regimen in
Eyes with Neovascular Age-Related Macular
Degeneration. Sarah Mrejen1, 2, J. J. Jung1, 5, R.
Gallego-Pinazo1, 3, I. Rusu1, 4, M. Marsiglia1, 2, S.
Boddu1, 4, K. Freund1, 2. 1Ophthalmology, Vitreous
Retina Macula Consultants of New York, New
York, NY; 2LuEsther T. Mertz Retinal Research,
Manhattan Eye Ear and Throat Hospital, New York,
NY; 3Ophthalmology, University and Polytechnic
Hospital La Fe, Valencia, Spain; 4Ophthalmology,
New York University School of Medicine, New
York, NY; 5Ophthalmology, Edward S. Harkness
Eye Institute Columbia, New York, NY *CR
3975 — C0277 Transitioning Neovascular
Age Related Macular Degeneration Patients
to Aflibercept Following an Initial Treat And
Extend Dosing Regimen: 18 Month Results.
Natalie Homer, D. S. Grewal, A. T. Lyon, R. Mirza,
M. Gill. Ophthalmology, Northwestern University
Feinberg School of Medicine, Chicago, IL
3976 — C0278 Photodynamic theraphy versus
intravitreal injection of anti-VEGF as treatment
for macular serous detachment in tilted disc
syndrome. Giulia Caminiti, E. Peiretti, M.
Fossarello, F. Meloni. Ophthalmology, University of
Cagliari, Cagliari, Italy
3977 — C0279 Despite detoriation in visual
acuity self-reported general vision function
was improved at a four-year follow up of
patients treated with ranibizumab for wet,
age-related macular degeneration. Lena Rung1,
M. Loevestam-Adrian2. 1dpt of opht, Hospital
of helsingborg, Helsingborg, Sweden; 2dpt of
ophthalmology, university hospital of Skåne, Lund,
Sweden
3971 — C0273 Qualitative OCT Appearance
and Vision Change in Eyes with Neovascular
AMD Treated with Anti-VEGF Drugs. Sanjeewa
Wickremasinghe1, 2, F. Abedi1, S. S. Sandhu1, 2, A.
Islam1, R. H. Guymer1, 2. 1Centre for Eye Research
Australia, East Melbourne, VIC, Australia; 2Medical
Retina, Royal Victorian Eye and Ear Hospital, East
Melbourne, VIC, Australia *CR
Tuesday, May 06, 2014 3:45 PM-5:30 PM
3972 — C0274 Retention of Good Visual
Acuity in Eyes with Neovascular Age-Related
Macular Degeneration and Chronic Refractory
Subfoveal Subretinal Fluid. Kavita Bhavsar1, 2,
K. Freund1, 2. 1Retina, Vitreous Retina Macula
Consultants of New York (VRMNY), New York,
NY; 2Retina, Columbia University, New York,
NY *CR
3978 — D0037 Human iPSC-derived neural
progenitor cells preserve vision in a rat retinal
degeneration model. YuChun Tsai, B. Lu, S.
Girman, B. Bakondi, M. K. Jones, A. Sahabian,
D. Sareen, C. Svendsen, S. Wang. Cedars-Sinai
Medical Center, Regenerative Medicine Institute,
Los Angeles, CA
3973 — C0275 Steady State Pattern
Electroretinography (ssPERG) in Age-Related
Macular Degeneration (AMD) compared to
controls. Peter H. Derr1, A. O. Gonzalez Garcia1, C.
Urgiles2, P. Seshadri2, R. Gentile3, 4, R. B. Rosen3,
C. Tello3. 1Engineering, Diopsys Inc, Pine Brook,
NJ; 2Einhorn Clinical Research Center, New York
Eye & Ear Infirmary, Mt. Sinai Health System, New
York, NY; 3Eihnorn Clinical Research Center and
Departments of Ophthalmology, New York Eye &
Ear Infirmary, Mt. Sinai Health System and New
York Medical College, Valhalla, NY; 4Department
of Ophthalmology, Winthrop University Hospital,
Mineola, NY *CR
3974 — C0276 The Potential of Aflibercept as
Monotherapy for the Treatment of Refractory or
Unresponsive Neovascular Age-Related Macular
Degeneration. Murilo W. Rodrigues, R. Jorge,
R. C. Siqueira, J. A. Cardillo. Retina Division,
Ribeirão Preto Medical School-University of São
Paulo, Ribeirão Preto, Brazil
Retinal Cell Biology / Retina
384 Stem Cell II: Restoration of
Photoreceptors
Moderator: Magdalene J. Seiler
3979 — D0038 Functional consequences of the
suppression of MHC-II expression on human
stem cell derived retinal pigment epithelium
(hES-RPE). Hossein Nazari Khanamiri1, K.
Ishikawa1, D. Zhu1, 3, S. T. Hikita4, D. O. Clegg4, D.
R. Hinton1, 3, M. S. Humayun1, 2. 1Ophthalmology,
CA; 2Biomedical Engineering and Cell and
Neurobiology, University of Southern California,
Los Angeles, CA; 3Pathology, University of
Southern California, Los Angeles, CA; 4University
of California, Santa Barbara, Santa Barbara,
CA *CR
3980 — D0039 Induction of RPE-specific
markers in human sweat gland-derived
stem cells by xenogeneic co-culture with
porcine RPE cells. Mahdy Ranjbar1, C.
Örün1, M. Brandenburger2, C. Kruse2,
S. Danner2, S. Grisanti1. 1Department of
Ophthalmology, University of Lübeck, Lübeck,
Germany; 2Fraunhofer Research Institution for
Marine Biotechnology, Lübeck, Germany
272
3981 — D0040 Cone Transplantation. Sher A.
Aslam2, 1, A. R. Barnard2, S. Sekaran2, M. S. Singh2,
R. E. MacLaren2, 1. 1Moorfields Eye Hospital,
London, United Kingdom;2Nuffield Laboratory
of Ophthalmology, University of Oxford, Oxford,
United Kingdom
3982 — D0041 Influence Of Hmga2 On
Photoreceptor Differentiation. Xiaohuan Xia,
S. Parameswaran, I. Ahmad. Ophthalmology and
Visual Sciences, Univ of Neb Med Center, Omaha,
NE
3983 — D0042 Human neural progenitor
cells are not sufficient to support degenerating
photoreceptors in cultured porcine retina.
Camilla Mohlin1, T. Mollick2, K. Johansson1, 2.
1
Natural Sciences, Medicine and Optometry,
Kalmar, Sweden; 2Örebro University, School of
Health and Medical Sciences, Örebro, Sweden
3984 — D0043 The involvement of IL-17RC
pathway in the inflammatory stimuli of the
multipotent retinal stem cells. Shida Chen1, 2,
D. Shen1, N. Popp1, J. Tuo1, M. S. Abu-Asab1, T.
Xie3, C. Chan1. 1National eye institution, Bethesda,
MD; 2Zhongshan Ophthalmic Center, Sun Yat-Sen
University, Guangzhou, China; 3Stowers Institute
for Medical Research, Kansas City, MO
3985 — D0044 Activation of mTORC1 is
sufficient for long-term cone survival in Retinits
Pigmentosa. Aditya Venkatesh, S. Ma, C. Punzo.
Ophthalmology and Gene Therapy Center,
University of Massachusetts Medical School,
Worcester, MA
3987 — D0046 Engineering Isogenic Best
Vitelliform Macular Dystrophy Patient iPS cell
lines using TALEN Technology. Ruchi Sharma, V.
Rajan, Q. Wan, K. Bharti. NEI, NIH, Bethesda, MD
3988 — D0047 Transplanted Mesc-Derived
Retinal Progenitors Differentiate To Mature
Photoreceptors In Vivo, Migrate And Integrate
In The Mice Retina. Marcela Garita, F. DíazCorrales, S. Erceg, S. Bhattacharya. Cell Therapy
And Regenerative Medicine, CABIMER, Sevilla,
Spain
3989 — D0048 Cell fusion following
photoreceptor transplantation into the nondegenerate retina. Mandeep S. Singh, S. A. Aslam,
I. L. Duncan, A. O. Cramer, A. R. Barnard, R. E.
MacLaren. Nuffield Laboratory of Ophthalmology,
University of Oxford, Oxford, United Kingdom
3996 — D0055 Silane-modified substratum
improves cell attachment of human embryonic
stem cell-derived retinal pigment epithelial
cells. Kati M. Juuti-Uusitalo1, 3, A. Sorkio1, 3,
E. Käpylä2, 3, S. Teymouri2, 3, K. Lahtonen4,
L. Vuori4, M. Valden4, H. Skottman1, 3, M.
Kellomäki2, 3. 1Institute of Biomedical Technology,
Univeristy of Tampere, Tampere, Finland; 2Dept.
of Electronics and Communications Engineering,
Tampere University of Technology, Tampere,
Finland; 3BioMediTech, Tampere, Finland; 4Surface
Science Laboratory, Tampere University of
Technology, Tampere, Finland
3991 — D0050 Intervention of ADSC
with modified medium on RCS rat. Chunpin
Lian1, 2, Z. Li1, 2, H. Lou1, 2, L. Wang1, 2, P. Li1, 2, H.
Tian1, 2, L. Lu1, 2, W. Li1, 3, G. Xu1, 2.1Department
of Ophthalmology of Shanghai Tenth People`s,
Tongji Eye institute, Tongji University School of
Medicine(TUSM), Shanghai, China; 2Department
of Regenerative Medicine and Stem Cell
Research Center, Tongji University School of
Medicine(TUSM), Shanghai, China; 3Department
of Ophthalmology, Drexel University College of
Medicine, Philadelphia, PA
3997 — D0056 Functional Analysis of Human
Protein Induced Pluripotent Stem Cell-derived
Retinal Pigment Epithelium. Jie Gong, M. A.
Fields, E. F. Moreira, Y. Koutalos, Z. Ablonczy, L.
V. Del Priore. Ophthalmology, MUSC Storm Eye
Institute, Charleston, SC
3992 — D0051 In-depth characterisation of
retinal pigment epithelium (RPE) cells derived
from human induced pluripotent stem cells
(iPSC). Caroline Brandl1, 2, S. Zimmermann2, F.
Grassmann2, V. Milenkovic3, A. Milenkovic2, J.
Käsbauer2, U. Hehr2, C. H. Wetzel3, H. Helbig1, B.
H. Weber2. 1Ophthalmology, University Hospital
Regensburg, Regensburg, Germany; 2Institute
of Human Genetics, Regensburg,
Germany; 3Psychiatry and Psychotherapy,
Molecular Neuroscience, University of Regensburg,
Regensburg, Germany *CR
3993 — D0052 Simple generation of selfforming neural retina and RPE cells from
confluent human iPS cells. Olivier Goureau1,
S. Reichman1, A. Terray1, A. Slembrouck1,
C. Nanteau1, G. Orieux1, C. Monville3, J. A.
Sahel1, 2. 1Institut de la Vision, UPMC Univ
Paris 06, UMR_S 968; INSERM U968; CNRS
UMR_7210, Paris, France; 2Centre Hospitalier
National d’Ophtalmologie des Quinze-Vingts,
INSERM-DHOS CIC 503, Paris, France; 3I-STEM,
INSERM; UEVE U861, Evry, France
3994 — D0053 A Stochastic Simulation to
Determine Stem Cell Localization in Retinal
Vasculature. Howard C. Ray1, B. Corliss1, S.
Cronk1, P. A. Yates1, 2, S. Peirce1, 2.1Biomedical
Engineering, University of Virginia, Charlottesville,
VA; 2Ophthalmology, University of Virginia,
Charlottesville, VA *CR
3995 — D0054 Co-culture of stem cell
derived retinal progenitors and retinal pigment
epithelium promotes tissue maturity. Peter Y.
Zhao1, S. Peng1, L. Ediriwickrema1, C. Qiu2, K. J.
Davis1, R. A. Adelman3, L. J. Rizzolo1. 1Surgery/
Ophthalmology, Yale University, New Haven,
CT; 2Cell Biology, Yale University, New Haven,
CT; 3Ophthalmology & Visual Science, Yale
University, New Haven, CT
3998 — D0057 Examination Of Gap Junction
Intercellular Communication In Human
Pluripotent Stem Cell-Derived Retinal Pigment
Epithelium. Clara Iglesias1, A. Sridhar1, S.
Ohlemacher1, J. S. Meyer1, 2. 1Biology, IUPUI,
Indianapolis, IN; 2Stark Neuroscience Research
Institution, Indiana University, Indianapolis, IN
3999 — D0058 Comparative analysis of retinal
layers after subretinal stem cell implantation
in Yucatan mini-pigs. Francisco R. Stefanini1, 2,
M. J. Koss1, 3, P. Falabella1, 2, M. Pfister1, D. R.
Hinton3, B. B. Thomas3, P. Thomas1, D. O. Clegg4,
M. S. Humayun3. 1Doheny Eye Institute, Los
Angeles, CA; 2Ophthalmology, Federal University
of Sao Paulo, Sao Paulo, Brazil; 3Ophthalmology,
CA; 4Univ of California-Santa Barbara, Santa
Barbara, CA *CR
4000 — D0059 Retrobulbar transplantation
of mouse Adipose tissue derived stem cells
rescues NaIO2 induced Retinal Degeneration
Mouse Model. Sang-Joon Lee1, J. Heo1, H. Kim2,
Y. Ahn3. 1Ophthalmology, Kosin University,
Busan, Republic of Korea; 2Ophthalmology, Inje
University, Busan, Republic of Korea; 3Biomedical
Endgineering and center for marine integrated
Biomedical technology, Pukyong National
University, Busan, Republic of Korea
4001 — D0060 A Triple-layer Co-culture
Model Of Neuroretina, RPE And AdiposeMSCs To Evaluate Cell Therapy In Retinal
Degeneration. Ivan Fernandez-Bueno1, 2, D.
Rodriguez-Crespo1, S. Di Lauro1, 3, A. K. Singh1,
M. Garcia-Gutierrez1, 4, M. Garrosa-García5, J.
Pastor1, 3. 1IOBA (Eye Institute), University of
Valladolid, Valladolid, Spain; 2Regenerative
Medicine and Cell Therapy Networking
Center of “Castilla y Leon”, Valladolid,
Spain; 3Ophthalmology, Hospital Clinico
Universitario, Valladolid, Spain; 4CIBER de
Bioingenieria, Biomateriales y Nanomedicina
(CIBER-BBN), Carlos III National Institute of
Health, Valladolid, Spain; 5Cellular Biology,
Histology and Pharmacology, University of
Valladolid, Valladolid, Spain
273
Tuesday Posters
3:45 pm – 5:30 pm
3986 — D0045 Using stem cells to develop gene
therapy for Batten Disease. Budd A. Tucker1, L. A.
Wiley1, K. Anfinson1, D. Ochoa1, J. Andorf1, L. M.
Affatigato1, A. V. Drack1, E. M. Stone1, 2. 1Stephen
A. Wynn Institute for Vision Research, Department
of Iowa, Iowa City, IA; 2Howard Hughes Medical
Institute, Department of Ophthalmology and Visual
Sciences, University of Iowa, Iowa City, IA
3990 — D0049 Subpopulations of bone marrow
mesenchymal stem cells exhibit differential
effects on delaying retinal degeneration. Peng
Li1, 2, H. Tian1, 2, Z. Li1, 2, L. Wang1, 2, C. Lian1, 2,
Q. Ou1, 2, L. Lu1, 2, W. Li1, 3, G. Xu1, 2. 1Department
of Ophthalmology of Shanghai Tenth Hospital,
and Tongji Eye institute, Tongji University School
of Medicine, Shanghai, China; 2Department of
Regenerative Medicine and Stem Cell Research
Center, Tongji University School of Medicine,
Shanghai, China; 3Department of Ophthalmology,
Drexel University College of Medicine,
Philadelphia, PA
4002 — D0061 Vascular stem cell therapy
of the diabetic retina with COMP-Ang1 and
endothelial progenitor cells. Judd M. Cahoon1,
P. R. Olson1, C. O2, R. J. Medina2, A. W. Stitt2, B.
Ambati1. 1Ophthalmology and Visual Sciences,
University of Utah, Salt Lake City, UT; 2Centre for
Vision and Vascular Science, Queen, Belfast, United
Kingdom
4003 — D0062 The relationships between
endothelial progenitor cells, inflammation,
and diabetic retinopathy. Dawn A. Sim1, 2,
P. A. Keane1, 2, C. A. Egan1, A. Tufail1, 2, M.
Fruttiger2. 1NIHR Biomedical Research Centre,
London, United Kingdom; 2Cell Biology, UCL
Kingdom *CR, f
4004 — D0063 IL-10-modified endothelial
progenitor cells suppress the progression of
non-proliferative diabetic retinopathy. Zhuhong
Zhang1, 2, Y. Wang1, F. Jiang1, H. Yan1.1Department
of ophtalmology, Tianjin Medical University
General Hospital, Tianjin, China; 2Moores Cancer
Center, University of California San Diego, San
Diego, CA f
Tuesday Posters
3:45 pm – 5:30 pm
4005 — D0064 Adipose Stromal Cells Atenuate
P38 Mapk In Retinal Ischemia-Reperfusion
Injury. Alexandra Vayl1, A. Gomaa1, G.
Rajashekhar1, 2.1Ophthalmology, Indiana University
School of Medicine, Indianapolis, IN; 2Cellular &
Integrative Physiology, Indiana University School
of Medicine, Indianapolis, IN
4006 — D0065 CD146+ Adipose stromal
cells localize and improve the retinal function
in I/R injury. Ahmed Gomaa1, A. Vayl1, G.
Rajashekhar1, 2. 1Opthalmology, Indiana University
School of Medicine, Indianapolis, IN; 2Cellular and
integrative physiology, Indiana University School of
Medicine, Indianapolis, IN
274
Tuesday – Symposia – 4007 – 4013
S 320AB
Tuesday, May 06, 2014 5:30 PM-7:00 PM
385 Where Are the Women? Exploring
Roles in ARVO
It’s no secret that ARVO’s leadership tends to be
male-dominated. Yet we count among our members
some of the world’s most outstanding women
scientists. So why are they under-represented on
the Board of Trustees, on our editorial boards and
among awardees? Join us for a unique session that
explores the role of women in ARVO’s leadership
in the context of some of the critical issues facing
women in the scientific and academic workforce
today. Presenters will discuss approaches to the
gender gap from the institutional, organizational
and country level perspectives; explore the pros and
cons of quotas; and share statistics unique to ARVO
about women in our globally diverse membership.
This eye-opening session is designed to be a
platform for attendees to actively participate and
share ideas about how we can strengthen ARVO by
ensuring that more of our women members
become leaders.
4010 — 6:06 How are we doing at ARVO?
Membership at ARVO. Joanne Olson. ARVO,
Rockville, MD
4011 — 6:14 How are we doing at ARVO?
Meetings at ARVO. Gayle Claman. ARVO,
Rockville, MD
— 6:22 Segment 3: The way forward how
should ARVO promote women’s leadership
— 6:22 Questions/Comments
4012 — 6:32 The way forward how should
ARVO promote women’s leadership: The
argument for and against quoats. David S.
Williams. UCL, Los Angeles, CA
4013 — 6:42 The way forward how should
ARVO promote women’s leadership: A
leadership course for women. Iris M. Rush.
ARVO, Rockville, MD
— 6:50 Working group on Women and ARVO:
should we have one and what are the priorities
— 5:30 Introduction
— 5:32 Segment 1: Approaches to the gender
gap
4007 — 5:32 Approach to the gender gap at the
institutional level. Lynn K. Gordon. UCLA, Los
Angeles, CA
Tuesday Symposia
5:30 pm – 7:15 pm
4008 — 5:40 Approach to the gender gap at an
organizational level. Hugh R. Taylor. University of
Melbourne, Melbourne, VIC, Australia
4009 — 5:48 Approach to the gender gap at
the country level. Sarah E. Coupland. Univ of
Liverpool/Sydney Jones Library, Liverpool,
United Kingdom
— 5:56 Questions/Comments
— 6:06 Segment 2: How are we doing at
ARVO?
275
NOTES
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276

Tuesday

Transcription

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