OrthoFoam MMP Wedge For Canine Cruciate Disease
Transcription
OrthoFoam MMP Wedge For Canine Cruciate Disease
OrthoFoam MMP Wedge For Canine Cruciate Disease User Guide OrthoFoam MMP Wedge User Guide History Rationale for technical development In the early 1960’s a human orthopaedic surgeon named Maquet working The perfect technique needs no further development. Consequently, if in Liege, Belgium described a tibial tuberosity advancement (TTA) a surgical technique is worthy of development, it is necessary first to procedure for the treatment of knee joint arthritis [1]. Human knee OA is define and describe shortcomings of the technique, as it exists. These a significant cause of pain and disability that is associated with loss of shortcomings become design and development targets. articular cartilage between the patella and femur. Maquet argued that advancing the tibial tuberosity would reduce patello-femoral pressure The Slocum TPLO arrived as a relatively well-developed and engineered and therefore reduce the pain and disability. The procedure appears to technique and subsequent modifications or developments have been have been successful but complications – typically due to fixation failure relatively modest in nature comprising minor modifications to surgical [2] – were not uncommon and the permanent and obvious disfigurement technique or changes to implant design. TPLO offers up few obvious of the patient’s knee was another drawback. areas for improvement. Notwithstanding these limitations, Maquet’s procedure gained some TTA has some theoretical advantages when compared with TPLO. popularity and it is the subject of several subsequent reports in the Notably, the long (weight bearing) axis of the tibia, which is cut in TPLO, human literature, summarised by Rappoport and colleagues (1992) [ ]. is preserved in TTA. Additionally, the work of Kim, Pozzi and colleagues Throughout the seventies and eighties several papers were published [7] showed that following TTA the stifle appears to retain a more normal that discussed the biomechanical consequences of TTA and noted that femoro-tibial contact pattern. 3 advancing the tibial tuberosity had potentially significant mechanical effects on the function of other key anatomy around the knee, notably However, TTA remains an extremely complex and technically demanding Mendes and colleagues (1987) [4]. surgical procedure. Complications are not uncommon and reflecting the original Maquet experience, these often relate to fixation failure During the 1980s and early 1990s the concept of managing cranial – such complications are typically very serious requiring additional cruciate ligament (CCL) failure in the dog using osteotomies to alter major surgery and a downwardly revised prognosis [8]. Fixation of the the mechanics of the stifle joint appeared. The two pioneers of this advanced tibial tuberosity is tenuous and relies on a multi-component work in dogs were Barclay Slocum and Slobodan Tepic who developed cage, plate and bone-screw device along with grafting procedures the tibial plateau levelling osteotomy (TPLO) and the tibial tuberosity to fill the considerable surgical dead space. The TTA procedure is advancement (TTA) respectively. It is not clear to what extent the work of limited to dogs requiring a relatively modest advancement (< approx Slocum and Tepic on the canine stifle was influenced by the much earlier 15mm) and this appears to be an implant-imposed limitation. A lengthy endeavours of Maquet working on the human knee. convalescence is required and this, too, appears to be dictated more by the limitations of the fixation system than due to any specific physiologic Relatively quickly, TPLO became established as the most popular factors. technique chosen by specialist veterinary orthopaedic surgeons when treating dogs with CCL failure [5]. Many tens of thousands of dogs have been treated using TPLO but since its more recent inception, TTA has There is some confusion about how the amount of advancement is become at least as popular. However, both TPLO and TTA are technically calculated. A lateral radiograph of the affected stifle in 135 degrees demanding surgical techniques and not surprisingly, the literature shows of extension as the most commonly used starting point. However, that complications, many of which are major, are not uncommon with considerable variation in distal femoral morphology exists and there either technique [6]. does not appear to be a universally agreed method of determining the femoral long axis and thereby establishing a reproducible radiographic datum. Furthermore, the work of Echteparaborde and colleagues (2011) [9] shows that the currently widely practiced technique of measuring 2 required advancement along the tibial plateau results in consistently fixation and enables bone augmentation. The availability of titanium low estimations and the error can become quite substantial when foam for use as an orthopaedic implant – licensed for veterinary use dealing with steep tibial plateau angles. Finally, one major supplier of under the name “Orthofoam” - was recognised as the key component to TTA hardware implies that such complex estimation is unnecessary, developing a simplified, robust TTA procedure. suggesting that small dogs get small advancements, medium size dogs get bigger advancements and the biggest dogs get the biggest Porous metals were proposed for implant fixation in the late 60’s as a advancements [10]. There appeared to be considerable potential to solution to problems encountered with methacrylate-based bone cement review the estimating procedure to improve accuracy and precision. [11,12,13]. These materials have been extensively studied since then and are now used routinely in various orthopaedic surgical procedures. The rough surface finish of the porous material provides the friction with Design and development targets surrounding tissues and promotes the initial fixation of the implant. The biological fixation is achieved after surgery through bone ingrowth into the porosity of the material. This biological fixation creates excellent Simplify the surgical technique implant-bone adhesion strengths [14] and secures the long term stability • Instrumentation of the implants. Many studies provided evidence of the efficiency of • Fixation biologic fixation with porous metals [15]. The fixation and stability are • Bone grafting/void-filling made possible only if the material structure, composition and properties are carefully adapted for the application [16]. Shorten the convalescence • Robust fixation system Important research and development activities were conducted to • “Less invasive” surgical technique develop materials with optimum structure and properties for implant fixation and bone augmentation. The National Research Council of Improve scope for advancement Canada has recently developed a process to produce highly porous • titanium foams with open porosity [17]. The process can be used to Enhanced stability/security of fixation produce porous implants with structure adapted for bone reconstruction Define a reproducible technique for estimation of and augmentation. The properties of this material and its biological required advancement behaviour have been reported in different studies [18,19, 20, 21, 22, 23, 24]. The foam is biocompatible and possesses mechanical properties which make it suitable for implantation in load bearing situations. The interconnected porosity permits rapid bone ingrowth and provides The development of a simple, robust method of advancing and fixing fixation to surrounding bone [25]. the tibial tuberosity was recognised as key to making any significant improvement to existing TTA techniques. The existing system, though Orthomed in conjunction with the IVOA began work with the National complex and costly is well engineered and effective. Given the technical Research Council of Canada in 2008 which has resulted in the first challenges of a relatively small tibial tuberosity fragment; considerable application of OrthoFoam in the MMP (Modified Maquet Procedure) traction; an inevitable bone void etc this system could not obviously be wedge for canine cruciate disease. significantly improved by evolution. Improvement has been made possible by the development of new implants and materials (i.e. titanium foam). The new foam wedge defines the degree of advancement of the tibial tuberosity while the open structure of the titanium foam allows bone ingrowth, promotes bone Version: 1.1 | Date: October 2011 | Author: Malcolm G. Ness 3 OrthoFoam MMP Wedge User Guide The Modified Maquet Procedure (MMP) Fig. 1 The Modified Maquet Procedure – so named to acknowledge the instigator of these operations – uses a wedge shaped implant of Orthofoam which both defines the degree of advancement of the tibial tuberosity and fixes the bone in its new place. The work of Echteparaborde and colleagues (2010) [26] demonstrated the importance of retaining a soft tissue bridge distally to effectively replace the complex plate-screw fixation described for conventional TTA and confirmed the benefit of a hole at the distal end of the osteotomy to control crack propagation. The creation of the osteotomy is facilitated by the use of a saw guide that ensures a cut of correct length precisely positioned to ensure an adequately “thick” tibial tuberosity fragment while locating the end of the osteotomy appropriately close to the cranial tibial cortex. The Orthofoam wedge can be manufactured in a range of sizes and provides Above is a backscattered scanning electron microscope image a robust fixation with impressive early stability. The open porous of a cross section through the 5mm porous Ti core of an implant structure encourages early in-growth of bone and removes the need harvested at 12 weeks. There is abundant bone within the pores to place graft/ bone substitute or similar. Initial stabilisation is achieved of the implant (seen in the image as grey colour), attesting to using a simple and inexpensive K wire and tension band because of the the suitability of the material for bone ingrowth fixation. This is material properties of the Orthofoam, the precision of the instrumented particularly impressive considering the initial 3mm gap between osteotomy, the preservation of soft tissues and the high coefficient of the porous implant and surrounding host bone. In this SEM friction between Orthofoam and bone, stability is predictable. image the Ti is white in colour and the void space is black. The gap has been filled with a demineralized bone matrix compound The MMP procedure capitalises on the known advantages of TTA. – this no doubt helped bone healing within the gap itself but However, the MMP technique is rapid, relatively simple, reproducible does not in itself account for all the bone formation within the and robust so most of the limitations of conventional TTA have been depths of the implant pores. eliminated. Furthermore, the development and rationalisation of a method for estimating the required tuberosity advancement offers L.Lim, J.D.Bobyn, K.M.Bobyn, L.P.Lefebvre, M.Tanzer, increased precision and reproducibility. Demineralized Bone Matrix Around Porous Implants Promotes Rapid Gap Healing and Bone Ingrowth, AAOS 2011 Annual Meeting, USA, (Otto Aufranc Award). Orthofoam MMP Wedge Fig. 2 - Method for estimating required tibial tuberosity advancement The desired end point of MMP surgery is a patella tendon angle of 90 degrees to the tibial plateau with the stifle in 135 degrees of extension. Although initially derived from theoretical considerations and mathematical modelling, informed to some degree by kinetic studies, the work of Apelt, Kowaleski and Boudrieau (2007) [27] provides supporting evidence for this method albeit from in vitro study. Clinical reports of excellent outcome following TTA surgery in many thousands of clinical cases provides further evidence that this 90 degree end-point is, at the 4 very least, an acceptable working hypothesis. There has been debate about how best to estimate the tibial plateau angle. The method described by Slocum (1993)[28] has stood the test of time and more recently a method involving common tangents has found some favour. De Rooster and Van Bree (1999) [29] reported a degree of radiographically apparent tibio-femoral subluxation associated with CCL failure and the common tangent modification (which has not been shown to be measurably better than the Slocum method) depends to some extent upon the spatial relationship between the tibia and the femur. Because this spatial relationship inevitably changes with failure of the CCL these techniques must, therefore, be flawed. Similarly, it is nearly impossible to collect a radiograph with exact joint angulation and the variable morphology of the distal femur makes accurate appraisal of the stifle joint angle rather subjective. The requirement to measure from a radiograph featuring the stifle in 135 degrees of extension inevitably introduces unacceptable and uncontrollable variation. Given this degree of anatomical and radiographic variability, it seems logical that a tibial osteotomy should be derived from datum points exclusively on the tibia. 5 OrthoFoam MMP Wedge User Guide Method to establish advancement for use with MMP wedge 01 Draw a line (A-B) along the tibial plateau extending caudally and cranially. 02 Locate the intercondylar eminence on the tibia. 03 Locate the mid-point of the intercondylar eminence on B A the tibial plateau line (C). 04 Draw a line (C-D) from this point to the centre of the tibial tarsal bone – the long axis of the tibia. C B A D 6 05 Draw a line (C-E) such that the angle DCE = 135 degrees. E 06 Locate point F, which is the most cranial part of the tibial tuberosity where the straight patella ligament 135º C A inserts. B F D 07 Draw a line (F-G) such that F-G is parallel with C-E. 08 Locate point H where F-G crosses A-B. G E H 135º C A B F D 7 OrthoFoam MMP Wedge User Guide 09 I a right angle. G E 135º J C H A Draw a line F-I to cross A-B at point J such that FJA is B F D 10 I G E L 135º J A C H B F D 8 Draw a line F-L through F and perpendicular to C-D. 11 I Draw a line through H and parallel to I-F which intersects F-L at M. G E L 135º J C H A F B M D 12 I Measure the distance F-M. This is the amount of advancement (Wedge Size) required to give a patella G E tendon angle of 90 degrees. L 135º J A C H F B M D 9 OrthoFoam MMP Wedge User Guide MMP Surgical Technique 01 The affected limb is clipped and prepared for aseptic surgery from just distal to the hip down to the hock joint. The patient is placed in dorsal recumbency and the limb draped to allow flexion and extension both of the stifle joint and of the hock. This shows the ‘surgeons eye view’ looking at the cranio-medial aspect of a left pelvic limb with the stifle towards the upper, right corner of the picture. 03 The limb is positioned such that the greater trochanter of the femur, the lateral aspect of the distal femur at the stifle, the lateral malleolus of the hock and the lateral aspect of the paw are all in contact with the tabletop while maintaining approximately ninety degrees of stifle flexion. This standard reference position establishes the saggital plane of the limb parallel to the tabletop. 10 03 A skin incision is made on the medial aspect starting proximally at the level of the mid-point of the straight patellar ligament and extending distally for eight to ten centimeters. 04 Avoid any further dissection. 11 OrthoFoam MMP Wedge User Guide 05 The incision is developed at the proximal end only: a short, medial, parapatellar joint capsule incision is made less than two centimeters long and approximately five millimeters behind the straight patellar ligament. The caudally angled, cartilage covered surface of the proximal tibia adjacent to the insertion of the straight patellar ligament is identified. Avoid excessive dissection. 06 An instrument (in this case a closed pair of Metzenbaum scissors) is pushed firmly behind the straight patella ligament to puncture the lateral joint capsule. The limb is held in the standard reference position and the instrument is driven perpendicular to the tabletop. This step is intended to facilitate the subsequent placement of the saw-guide locating pin. 12 07 The proximal (long) pin of the MMP saw guide is placed behind the straight patellar ligament such that the proximal pin contacts the angled, cartilagecovered surface of the proximal tibia. The diameter of the distal (short) pin can be selected between 3 and 6 mm. The diameter of this pin controls the position of the osteotomy and therefore thickness of the tibial tuberosity fragment. For most cases the smaller (3 or 4 mm) pin will be appropriate. 08 Inspect the anticipated size of the tibial tuberosity fragment and modify through varying guide position and distal pin diameter. The MMP saw guide is fixed using the short 3.5mm drill, which is advanced through both tibial cortices. Prior to drilling, the limb is returned to the standard reference position, ‘see step 2 above’ and the drill is placed perpendicular to the tabletop. The chuck is removed leaving the drill in place thereby fixing the MMP saw-guide in place. 13 OrthoFoam MMP Wedge User Guide 09 The osteotomy is made: a saw blade with a thickness of approximately 0.7mm should be used. The MMP saw-guide and the geometry of the MMP wedge is designed around a saw cut of this size. 10 On completion of the osteotomy, the 3.5mm drill bit is removed. 14 11 The MMP saw-guide is removed. 12 A bony bridge between the distal end of the saw slot and the 3.5mm drill hole persists. This is identified and cleared of any overlying fascia. Avoid excessive dissection – it is essential that all soft tissue distal to the end of the osteotomy is preserved untouched. 15 OrthoFoam MMP Wedge User Guide 13 Removing the small bony bridge using the same oscillating saw completes the osteotomy. NB the bone of the tibial tuberosity is hard so copious irrigation should be used. Irrigation was not used in this cadaver series to ensure image quality. 14 A pair of small pointed reduction forceps is placed across the proximal end of the osteotomised tibial tuberosity. Gentle traction confirms that the osteotomy has been completed successfully. Occassionally, further use of the bone saw will be required to complete the osteotomy proximally and in that case the saw guide must be replaced. An important function of the saw guide is to protect the straight patella ligament and other, intra-articular structures from iatrogenic damage. 16 15 The smallest trial wedge is offered up to the osteotomy – the small pointed reduction forceps facilitate this process. 16 Increasingly large trial wedges are placed until the desired size is reached. 17 OrthoFoam MMP Wedge User Guide 17 The distal tip of the wedge should lie within 1mm of the 3.5mm drill hole and the medial aspect of the wedge should lie on, or slightly proud, of the medial tibial cortex. The proximal end of the wedge will lie below the proximal extremity of the tibial tuberosity. 18 Ensure that there is no tendency for soft tissue to be “dragged” in between the trial wedge and the bone. 18 19 Larger trial wedges are placed and evaluated sequentially. 20 The final trial wedge is placed - in this case 12mm. 19 OrthoFoam MMP Wedge User Guide 21 The appropriate Orthofoam MMP wedge is loaded into MMP insertion device and placed exactly as predicted by the trial wedge. 22 Positioning of the wedge is reviewed: the distal tip of the wedge should lie within 1mm of the 3.5mm drill hole and the medial aspect of the wedge should lie on, or slightly proud, of the medial tibial cortex. The proximal end of the wedge will lie below the proximal extremity of the tibial tuberosity. Check that there is no soft-tissue entrapment. 20 23 The butterfly drill-guide is placed onto the MMP insertion device. Two butterfly drill-guides are provided, identical but for the length of the locating pins. Cases with a thinner tibial tuberosity and a significant medial buttress will need the short-pinned guide while the butterfly drill-guide with the longer pins will be appropriate in most cases. 24 A 1.5mm drill bit is used to make a hole through the tibial tuberosity only. The butterfly drill-guide will line up this drilling with the hole in the Orthofoam wedge. Avoid drilling beyond the wedge – specifically, do not drill the tibial diaphysis. 21 OrthoFoam MMP Wedge User Guide 25 A 1.6mm Kirschner wire (size critical) is placed through the butterfly drill guide and advanced until firmly seated in, but not penetrating, the caudal tibial cortex. 26 The butterfly drill-guide is removed by gently sliding it back off the K-wire. 22 27 The MMP insertion device is removed by unscrewing the handle a few turns before gently lifting the hooked head up and over the Orthofoam wedge. 28 Preparing the holes for the figure of eight wire. Start the proximal hole as shown using a 1.5mm drill bit: locate the starting point approximately two thirds of the distance between the K wire and the end of the osteotomy and start the hole very close to the edge of the osteotomy. Drill no more than half a millimeter deep in this direction. 23 OrthoFoam MMP Wedge User Guide 29 As soon as possible, re-direct the drill at an angle between thirty and forty five degrees to the vertical and continue drilling such that the hole exits the lateral aspect of the tibia close to its cranial extremity. Avoid any dissection – it is essential that the soft tissues in this region are preserved untouched. 30 Patients up to 25kg (55lb) A second 1.5mm drill hole is started. Its centre should be approximately ten millimeters from the centre of the 3.5mm hole at the distal end of the osteotomy. Its position should be such that the tension-band wire will act at approximately forty five degrees to the tibial long axis. Medio-lateral radiograph showing the desired location of the tension band wire. 24 31 A length of orthopaedic wire, 1.0 (minimum) – 1.2mm diameter (size critical) is pushed from medial to lateral. Avoid all dissection – the wire will find a path through the soft tissues without the need to do any dissection whatsoever. Preservation of the distal soft tissue bridge is essential. 32 A second short length of orthopaedic wire, 1.0 (minimum) – 1.2mm in diameter (size critical) is passed through the distal hole in similar fashion. Again, it is important that all dissection is avoided. The size of orthopaedic wire is rather larger than many surgeons will be used to selecting for similar applications. However, the magnitude and direction of forces acting here after advancing the tibial tuberosity requires that a substantial wire tension band is used. 25 OrthoFoam MMP Wedge User Guide 33 The figure of eight pattern is laid in routine fashion and great care is taken to ensure that the twists are made evenly and neatly. 34 Two symmetrical twists are needed to provide even tightening of this relatively thick wire. Each “arm” of the figure eight is tightened in turn to maintain even tension. 26 35 The wire should end up “snug” rather than very tight – the aim is to prevent creep and not to apply compression. 36 The twists are cut to length and bent over to lie flush with the underlying structures. 27 OrthoFoam MMP Wedge User Guide 37 Patients over 25kg A 2.7mm hole is started in the position shown in box 30. It’s position should be such that the tension-band wire will act at approximately forty five degrees to the tibial long axis. The large hole acts as the distal anchor point for both orthopaedic wires as shown in the radiograph. 4 Week Follow UP Courtesy of Dr Duncan Midgley, BVMS, CertSAO, MRCVS, Rutland House Referrals, UK. 38 The K-wire is cut leaving approximately 10mm protruding. 28 39 The protruding K-wire is bent medially to a right angle using the MMP K-wire bender. 40 The bent K-wire is rotated to lie against the craniomedial aspect of the tibial tuberosity. 29 OrthoFoam MMP Wedge User Guide 41 The soft-tissues are closed using a single simple continuous suture of 3metric or similar before the skin is closed using a single continuous suture of 2 or 3 metric monofilament nylon or similar. 42 Bandages and complex dressings are unnecessary – the wound is protected using two or three rolled sterile gauze swabs (sponges) held in place with three simple interrupted sutures of 2 or 3 metric monofilament nylon or similar. 30 After-care information for clients short leash walks – 5-10 minutes six or eight times daily is a good starting point. It is important that the operated knee joint is returned to Your pet’s cranial cruciate ligament failure has been treated surgically use as quickly as possible - concentrate on walking relatively slowly as using the Modified Maquet Procedure (MMP). The operation is based this will encourage the patient to use the leg. Ideally, your dog should go on a technique developed almost 50 years ago for use in human knees outside ON A LEASH to toilet during the first two weeks after surgery. by Dr Maquet, a Belgian orthopaedic surgeon. The operation works Do not swim the dog. by redirecting the force generated by the large quadriceps muscles to No other exercise is recommended for the first 14 days - it is important compensate for the failed cruciate ligament. This is achieved by cutting to not let your pet loose to run freely in the house, particularly up and free, and moving forward, the part of the tibia (the tibial tuberosity) down stairs. attached to the quadriceps muscle. The bone cut is called an osteotomy and the osteotomy is stabilised using a modern orthopaedic implant material called Orthofoam. The porous titanium Orthofoam promotes Third and fourth weeks remarkably rapid bone ingrowth and healing and this is key to the reduced convalescence and minimal pain seen with MMP surgery. The amount of activity can now be gradually increased but it is essential that the patient is not allowed off the leash until after the 4 week X-ray Successful recovery after knee surgery, no matter which procedure has check. been used, requires a period of controlled activity. Compared to other Leash walks can be longer and faster though take care to ensure that the procedures, MMP causes less discomfort and while a comfortable, pain- patient continues to use the operated limb confidently at every step. free patient is obviously a good thing, many dogs are tempted to use the operated leg too much, too soon. No matter how comfortable and confident your pet is feeling in the days after their MMP operation, it is Fifth and sixth weeks absolutely essential that running, jumping, and general “rough and tumble” with other pets is avoided for the first 6 weeks or Check X rays are scheduled for the end of week four and these should so. The bone must be given time to heal adequately and too much strain confirm that the osteotomy is healing well. Bear in mind that although placed on the osteotomy too early can result in stress fracture or implant bone healing and remodelling will be progressing nicely, full strength will failure and while this is rarely catastrophic, the ensuing complication may not be established for several more weeks. be painful and will certainly delay the recovery. At this stage, the patient will be capable of frequent lengthy (30 minutes or more) leash walks and we will soon be introducing some free running activity. The key to success is a programme of gradually increasing First and second weeks activity. At first, the patient can be allowed off the leash towards the end of the last walk of the day – choose a quiet area with a good surface – a Your dog will have a short course of antibiotics and a longer course of short cut grassy park is ideal - without dogs or other distractions that a non-steroidal anti-inflammatory drug (NSAID). Treatment with NSAIDs might encourage your pet to do too much too soon. Five minutes is will usually continue for at least six weeks while the osteotomy heals. enough for the first day off the leash. Subsequently, the amount of free running play and exercise can be increased gradually back towards Bandages are not used following MMP because it is important that your normal pre-injury levels. Most dogs will be capable of full, unrestricted pet is able to flex and extend the operated knee freely right from day athletic activity within 12 weeks of their MMP operation. Some residual one. A gauze pad is sutured over the skin incision to protect the wound. low grade stiffness and lameness may still be seen at twelve weeks The pad can be removed after five days or so and the skin sutures are but this will resolve completely over the subsequent month or two as removed a fortnight after surgery. the patient regains full fitness and the osteotomy completes its healing process. During the first 14 days, your pet should be encouraged to take frequent 31 OrthoFoam MMP Wedge User Guide References 1 Maquet P, Advancement of the tibial tuberosity. Clin Orth 1976; 11 115:225 2 Bessette-GC; Hunter-RE, The Maquet procedure – A retrospective Hirshhom HS, McBeath AA, Dustoor MR, Porous titanium surgical implant materials. J BioMed Mater. 1971 2:49. 12 review. Clin-Ortho. 1988 Jul(232): 159:67 Petersen CD, Miles JS, Sotomons C et al, Union between bone and implants of open pore ceramic and stainless steel: a histologic study. J Bone Joint Surg. 1969; 51A 805. 3 Rappoport LH et al, The Maquet osteotomy. Orth Clin of North Am No.4 1992; 645:656 13 Cameron HU, Pilliar RM, McNab I, The effect of movement on the bonding of porous metal to bone. J Biomed Mater Res., 1973; 7(4) 4 Mendes DG, Soudry M, Iusim M, Clinical assessment of Maquet 301:11. tibial tuberosity advancement. Clin Ortho. 1987 (222) 228:38 14 5 Bobyn, J. D., Pilliar, R. M., Cameron, H. U., Weatherly, G. C., and Leighton RL, Preferred method of repair of cranial cruciate ligament Kent, G. M, The effect of porous surface configuration on the tensile rupture in dogs: a survey of ACVS diplomates specializing in canine strength of fixation of implants by bone ingrowth. Clin Orthop. 1980; orthopedics. American College of Veterinary Surgery. Vet Surg. 1999; 291:298. 28(3):19 15 6 Lafaver S, Miller NA, Stubbs WP, Taylor RA, Boudrieau RJ, Tibial M.Spector, Historical Review of Porous-Coated Implants, J.Arthroplasty, Volume 2, Issue 2, 1987; 163:177. tuberosity advancement for stabilization of the canine cranial cruciate ligament-deficient stifle joint: surgical technique, early 16 results, and complications in 101 dogs. Vet Surg. 2007;36(6) 573:86 Bobyn, J. D., Pilliar, R. M., Cameron, H. U., and Weatherly, G. C, The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clin Ortho. 1980; 263:270. 7 Kim SE, Pozzi A, et al, Effect of tibial tuberosity advancement on femero-tibial contact mechanics and stifle kinematics. Vet Surg. 17 US 6,660,224, WO 03/015963 18 Wazen R, Lefebvre LP, Baril E, Nanci A, Initial evaluation of bone 2009; 38 (1)33:39 8 Lafaver S, Miller NA, Stubbs WP, Taylor RA, Boudrieau RJ, Tibial ingrowth into a novel porous titanium coating, J.Biomedical Mat. tuberosity advancement for stabilization of the canine cranial Res.-Part B; 2010, 94 (1), 64:71. cruciate ligament-deficient stifle joint: surgical technique, early results, and complications in 101 dogs. Vet Surg. 2007;36(6) 573:86 19 Lim L, Bobyn JD, Lefebvre LP, Tanzer M, Efficacy of Bone Graft Substitute Materials for Gap Healing Around Porous Titanium 9 Echteparaborde S, Mills J, Busoni V, Brunel L, Balligand M, Implants, 57th Annual Meeting of the Orthopaedic Research Society, Theoretical discrepancy between cage size and efficient tibial Long Beach, California, USA, January 13-16, 2011. tuberosity advancement in dogs treated for cranial cruciate ligament rupture. VCOT. 2011: 24(1) 27:31 20 Baril E, Lefebvre LP, Hacking A, Direct Visualization and Quantification of Bone Growth Into Porous Titanium Implants 10 Veterinary Instrumentation Catalogue 2010. using Microtomography, Journal of Material Science: Materials in Medicine, 2011 (online). 32 21 Lefebvre LP, Baril E, Bureau MN, Effect of Oxygen Content on the Static and Cyclic Deformation of Titanium Foams, J.Mat.Sci.: Materials in Medicine, Volume 20, Number 11 / November, 2009; 2223:2233. 22 Lefebvre LP, Baril E, Effect of oxygen concentration and distribution on the compression properties on titanium foams, Advanced Engineering Materials. 2008; 10 (9) 868:876. 23 St-Pierre JP, Gauthier M, Lefebvre LP, Tabrizian M, “Threedimensional growth of differentiating MC3T3-E1 pre-osteoblasts on porous titanium scaffolds”, Biomaterials, 2005; vol.26, no.35, 7319:7328. 24 Menini R, Dion MJ, So V, Gauthier M, Lefebvre LP, “Surface and Corrosion Electrochemical Characterization of Titanium Foams for Implant Applications” J.Elect. Chem. Soc., 153, (1), 2006, B13:B21. 25 http://www.youtube.com/watch?v=hdscnna5r1Q 26 Echteparaborde S, Barthelemy N, Mills J, Pascon F, Ragetly GR, Balligand M, Mechanical testing of a modified stabilisation method for tibial tuberosity advancement. VCOT. 6/2010; 400:405 27 Apelt D, Kowaleski MP, Boudrieau RJ, Effect of tibial tuberosity advancement on cranial tibial subluxation in canine cranial cruciatedeficient stifle joints: an in vitro experimental study. Vet Surg 2007; 36(2) 170:77 28 Slocum B, Slocum TD, Tibial plateau levelling osteotomy for repair of cranial cruciate ligament rupture in the canine. Vet Clin North Am Anim Pract. 1993; 23 777:795 29 De Rooster H, Van Bree H, Radiographic measurement of craniocaudal instability in stifle joints of clinically normal dogs and dogs with injury of a cranial cruciate ligament. Am J Vet Res 1999; 60(12) 1567:70 33 OrthoFoam MMP Wedge User Guide Notes 34 35 Orthomed (UK) Ltd 23 Mountjoy Road Edgerton Huddersfield W Yorkshire HD1 5QB Tel: +44 (0) 845 045 0259 Fax: +44 (0) 845 603 2456 Email: [email protected] Orthomed North America Inc. 927 Azalea Lane Suite A Vero Beach Florida 32963 Tel: +1 772-492-0111 Fax: +1 772-492-0444 Email: [email protected] Orthomed Technology GmbH Am Schaafredder 17 24568 Kaltenkirchen Germany Tel: +49 (0) 4191 8030013 Fax: +49 (0) 4191 8030014 Email: [email protected] Orthomed (SA) Pty Ltd Plot 90 Henry St Shere A.H Pretoria 0042 Tel: +27 (0) 83 227 8181 Fax: +27 (0) 86 649 0686 Email: [email protected] The home of Veterinary Orthopaedics www.orthomed.co.uk
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