Epilepsy - Identifying Epileptical Sources in the Human Brain

Epilepsy - Identifying Epileptical
Sources in the Human Brain
Behavioral events
Epileptic activity is rather focal
SCI Contributors
2012
Moritz
Dannhauer
Rob
MacLeod
Burak
Eram
Dana
Brooks
Damon
Hyde
Simon
Warfield
70%
Abnormal brain signals
Traditional
treatment
~20%
Drugs not
effective
Where is the source of epilepsy
for this specific patient?
Case Study
- 11 year old boy
- medically intractable epilepsy
- tumor anterior to motor area
Children’s Hospital
Northeastern
Boston
University, Boston
Surgical planning
epileptic source
localization
using non invasive
measurements
Magnetoencephalography
(MEG)
use
estimated
source location
for
Electroencephalography
(EEG)
Source Localization Pipeline
Magnetic resonance image (MRI)
Image aquisition & processing
Epileptic spike activity surface EEG
EEG rawdata epileptic
spikes marked
Tissue segmentation
Identification of structures
Electrode positions &
Measurements
Volume model (Meshing)
Tetrahedral Mesh
Source Localization
Source localization result - surface EEG (red arrow)
vs. implanted electrodes (source under orange electrodes)
Epileptic source localization result localized close to tumor tissue
www.sci.utah.edu