full presentation - Med-e-Tel
Transcription
full presentation - Med-e-Tel
Smart Diagnosis: current applications and future challenges Med-e-Tel conference Luxemburg April 9, 2014 Prof. Sabine Van Huffel Outline • Introduction • 3 case studies • Future challenges • Personalized: "customized" diagnosis and treatment • Preventive: prevention is always better than curation, tailored to the individual patient • Predictive: precise predictions with modern technology, determine risk profiles, predict progression and outcome • Participatory: correct and complete information for the patient to participate in the decision process 3 3 Lots of data Temporal Data Laboratory data monitoring Staff observations 9/04/2014 4 Process large amounts of time-dependent data! ? Brain monitoring for neurological diseases Algorithms (Technology) Sensors (Carriers) Vital signs monitoring: sleep, stress, cardio risk stratification Pathologies (Applications) Smart Diagnosis Oncology: cancer diagnosis and prognosis Chronic disease management & telemonitoring application Research topics in Biomedical Data Processing @ •EMG & HRV signal processing for stress monitoring •MR Spectroscopic quantitation & brain tumor recognition using MRS(I) •(Functional) Near-Infrared Spectroscopy & neonatal brain monitoring •Cardiovascular dynamics, sleep monitoring & HRV analysis •Preoperative cancer diagnosis & prognosis: ovarian, prostate, brain, breast •EEG based signal processing for epileptic monitoring and ERP analysis •Video/accelerometry for epileptic seizure monitoring •Spike classification in deep brain recordings & high-density surface EMG NXT_SLEEP: next generation sleep monitoring platform • Sleep‐related breathing disorders • Major impact on cardiovascular health • Prevalence: around 4% in men and 2% in women. • Severely under diagnosed • Limited availability of clinical screening • Polysomnography: time‐consuming, costly, uncomfortable Insomnia Nocturia Fatigue Snoring Sleep Breathing Disorder Morning headache Depression Obstructive Sleep Apnea Dry mouth throat Attention deficit Memory loss NXT_SLEEP: next generation sleep monitoring platform Apnea episodes in the heart rhythm Apnea 1 0.5 0 0 10 20 30 Time (s) 40 50 60 Apnea episodes in the respiratory signal 1400 RR(ms) 1200 1000 800 600 0 10 20 30 Time (s) 40 50 60 NXT_SLEEP: next generation sleep monitoring platform Epilepsy monitoring • EEG (clinic) golden standard for epilepsy monitoring • Non‐EEG video, audio, radar, ECG, respiration, EMG,ACM • Commercially available systems: → Efficiency lacks (long, intense & repe ve movement only, excessive false alerts) or insufficiently proven → Few seizure logging (EpiWatcher, SmartWatch, EpiCare) → Single modality → No video data storage Video‐accelerometry epilepsy monitoring at revalidation center Pulderbos wrist‐band‐like wireless accelerometers feature extraction from video Automated motor seizure detection using accelerometers and video 11 Video‐accelerometry epilepsy monitoring at revalidation center Pulderbos Long‐term Epilepsy monitoring: first results camera radar • User friendliness: < program setting steps at start‐up laptop for storage (Bluetooth) & offline analysis ACM for wrists & ankles, put in elastic bracelets • 4 patients with motor seizures monitored during 1 month • 71 % of the data analyzed (loss due to technical problems) • Comfort: < 4 bracelets & < easy to remove • Efficiency: – 25 % missed (due to defects, mistakes in reporting, misclassified seizures) – Not yet sufficiently reliable for detection or alarm but screening tool to detect the 50 % extra seizures Future Challenges in Epilepsy monitoring: Home Monitoring & multimodal data acquisition EEG Acceleration ECG 9/04/2014 Video EEG ECG EMG EOG video audio 14 acceleration NeoGuard: Neonatal Brain Monitoring • Partners KU Leuven-ESAT (STADIUS and MICAS), UZ Leuven neonatology, EMC Rotterdam, ZNA Middelheim, Ghent Univ. • Addressing main problems with infant EEG • • • • EEG electrodes not baby friendly Manual (subjective) interpretation 24/7 availability of EEG experts Goals: – – – Produce EEG instrument for continuous brain monitoring (real-time, bedside) Validate automated seizure detection & background classification program Automated clinical decision support NeoGuard : Clinical Research Despotovic et al, Human Brain mapping, 2013 Neonatal epileptic seizures Koolen et al, Clini.Neurophys. Accepted, 2014 Inter-burst intervals in premature EEG NeoGuard: Future Challenges in Development Monitor development Algorithm development and optimization Clinical studies (combined with EEG and MRI findings) Multimodality monitoring • Multilevel: Bedside version for daily clinical use (only show clinical relevant information) and Extensive research version • Validation: improved interobserver agreement • Telemedicine kit for mobile neonatal healthcare • EEG background activity quantification : more features, multichannel, connectivity, dynamics evolution • Source localization: including dynamics of seizures • Patient customized settings • Adding non-linear entropy analysis, autoregulation • Improvement outcome by monitoring: • Improved understanding clinical relevance seizure types : spike versus oscillation, rhythmicity, frequency, etc • Improved understanding clinical relevance EEG background characteristics: SW cycling, frequency content bursts, sharp waves, etc • NIRS • EEG cap: dry electrodes, smart textile • Polygraphy: ECG, HRV, Respiration, SaO2, CO2 • Movement (automated video recognition?) integrated, BAN, wireless improved comfort Future Challenges in Tech Transfer Technology transfer to market in medical technology is a though job !! o many different stakeholders o non-trivial business models o hyper-regulated environment with separated policy levels o totally different systems in other countries o many ethical and legal issues o niche market of medical diagnostics • societal valorization is often more important than a pure economic point of view • non-straightforward CE labeling or FDA approval economic societal societal Innovative solutions for chronic diseases Telehealth facilities Intelligent devices Intelligent systems supporting decisionmaking Intelligent organisation of care 12 partners from the Netherlands, United Kingdom and Belgium join forces to overcome problems/barriers linked to lack of support for businesses to market new, smart telehealth products. • • • • • • Brainport Development N.V. [NL] Technische Universiteit Eindhoven [NL] Catharina-ziekenhuis [NL] Katholieke Hogeschool Kempen [BE] Stad Turnhout [BE] Academisch Ziekenhuis Maastricht [NL] • • • • • • Stichting IMEC Nederland (IMEC-NL) [NL] Health Enterprise East Ltd. [UK] KU Leuven, Research and development [BE] Algemeen Ziekenhuis Turnhout [BE] Universiteit Maastricht [NL] North East London Foundation Trust [UK] www.regionalcareportals.eu Please join our RECAP symposium this afternoon in Conference room 1! 14:00-15:30hr - RECAP Symposium: Intelligent 16:00-17:30hr - RECAP Symposium: Intelligent Systems Supporting Decision-Making (1) – Systems Supporting Decision-Making (2) – Conference room 1 Conference room 1 • Introduction to the RECAP (Regional Care Portals) Project Telehealth for Patients with Heart Failure: A Comparison Marcel de Pender (Programme Manager), Brainport Between Telehealth Systems Development, The Netherlands Carolina Varon & Prof. Sabine Van Huffel, Department of Philips Motiva System Electrical Engineering, KU Leuven, Belgium Sharon Donald (Business Development Manager Telehealth UK and EU Telehealth Market Analysis UK & Ireland), Philips Healthcare, UK Nicholas Offer (SBRI Project Manager) & Stuart Thomson (Head Doc@Home System of Medical Technology), Health Enterprise East, UK Adrian Flowerday (Chief Executive) Docobo, UK RECAP Telehealth Project - The Patient Perspective RECAP Telehealth Integration into Community Care Michelle Stapleton (Integrated Care Director) & Jan Minter (Nurse Michelle Stapleton (Integrated Care Director), Jan Minter Consultant, Lead for Community Heart Failure) North East London (Nurse Consultant, Lead for Community Heart Failure) North NHS Foundation Trust (NELFT), UK • • • East London NHS Foundation Trust (NELFT), UK
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