Experimental Biology 2016 Program

Transcription

FRIDAY, APRIL 1
Biochemistry and Molecular Biology
1.
ASBMB GRADUATE AND POSTDOCTORAL
TRAVEL AWARD PROFESSIONAL
NETWORKING EVENT
Special Event
Fri. 5:30 pm—San Diego Convention Center, Room
6A Foyer
Cochaired: C. Heinen and T. O’Connell
Invitation only. Required participation by all Graduate/
Postdoctoral and Graduate Student MAC Supported Travel
Award recipients.
Follow the conversation: #education
Nutrition
2.
ASN SPONSORED SATELLITE PROGRAM:
A GLOBAL APPROACH TO PERSONALIZED
NUTRITION FROM THE GENOME TO THE
MICROBIOME
4.
ASN CAROTENOID AND RETINOID
INTERACTIVE GROUP (CARIG) ANNUAL
SYMPOSIUM AND BUSINESS MEETING
Special Event
ASN Satellite
(Sponsored by: CARIG RIS)
(Organized and Sponsored by: Herbalife)
Fri. 1:00 pm—Hilton San Diego Bayfront, Aqua AB
Fri. 8:00 am—Hilton San Diego Bayfront, Indigo D
Chaired: D. Heber
Chaired: S.A. Tanumihardjo
Reception and CARIG Poster Competition to follow in Aqua C
Visit the Exhibits
April 3–April 5
Exhibit Hours
Sunday – Tuesday
9:00 am – 4:00 pm
1
SATURDAY, APRIL 2
Across Societies
5.
10:00
CAREER DEVELOPMENT WORKSHOPS
Workshop
Sat. 9:00 am—San Diego Convention Center, Exhibit Hall D
Career Development
The following workshops will be held in the EB2016/FASEB
Career Center. Access to the Career Center is FREE to all
registered Experimental Biology 2016 meeting attendees.
Poster/Platform Presenter Preparation Workshop and
Practice Lab
FASEB MARC Program will sponsor a Poster/Platform
Presenter Preparation Workshop and Practice Lab beginning
Saturday, April 2, to provide FASEB MARC poster/oral
presentation travel award recipients and other interested EB2016
student/postdoc attendees with an opportunity to practice their
presentations and obtain feedback from designated Workshop
Mentors/Coaches. If you would like to participate in this
workshop/practice lab, sign-up onsite at the Career Center
beginning Saturday morning, April 2. First-come, firstserved. Limited space/session availability.
9:00
9:00
9:30
Networking: Optimizing Your Time at EB2016. J.
Tringali. Tringali & Assocs. Inc.
Get Up With Something on Your Mind. H. Adams. H.G.
Adams & Assocs. Inc., Norfolk, VA.
How to Choose Your Ideal Career. B. Lindstaedt. UCSF.
Negotiation Strategies for Scientists Part 1. D. Behrens.
Univ. of California, Berkeley.
10:30 Understanding Search Committees & Finding
Job Announcements. A. Green. Univ. of
California, Berkeley.
11:00 But I Have No Skills!. J. Lombardo. Med. Col. of
Wisconsin and Marquette Univ.
11:00 Beyond the Bench: Preparing for Your Career Transition
in the Life Sciences. J. Tringali. Tringali & Assocs. Inc.
1:00
Job Hunting in Biotech Part 1: Finding & Applying for
Scientist Positions. B. Lindstaedt. UCSF.
1:00 Transforming Your CV/Cover Letter for Industry
Positions. N. Saul. UCSF.
1:00
2:00 Networking: A Required Life Skill. H. Adams. H.G.
2:30
Job Hunting in Biotech Part 2: Interviewing for Scientist
Positions. B. Lindstaedt. UCSF.
2:30 Developing Your Core Message/ “Elevator Pitch”.
J. Lombardo. Med. Col. of Wisconsin and
Marquette Univ.
3:00 Networking: Optimizing Your Time at EB2016. J.
Tringali. Tringali & Assocs. Inc.
4:00
Job Hunting in Biotech Part 3: Compensation Negotiation
for Scientist Positions. B. Lindstaedt. UCSF.
4:00 Creating Effective CV’s Cover Letters, Research
& Teaching Statements. A. Green. Univ. of
Anatomy
6.
UNLOCKING YOUR POTENTIAL IN ACADEMICS:
SEIZING OPPORTUNITIES TO SUCCEED WHILE
AVOIDING PITFALLS
Symposium
Sat. 8:30 am—San Diego Convention Center, Room 7B
Chaired: H.W. Lambert
Professional Development
Career Development
8:30
Chair’s Introduction.
8:35 6.1
Finding the Elusive Pathway to Promotion as
an Educator. H.W. Lambert, M.J. Zdilla, P.S. Klinkhachorn.
West Virginia Univ. Sch. of Med. and West Liberty Univ.
9:00 6.2
Achieving Tenure as a Clinical Researcher.
K.B. Foreman. Univ. of Utah.
9:25 6.3
Strategies for Getting Promoted in a Difficult
Granting Environment. J.A. Guttman. Simon Fraser
Univ., Canada.
9:50
General Discussion.
2
7.
“ONCE UPON A TIME”: CULTIVATING THE
SKILL OF STORY TELLING
Symposium
Chaired: A. Poznanski
Career Development
10:30 7.1
The Elements of Story Telling. A. Poznanski.
California Northstate Univ. Col. of Med.
10:50 7.2
A Very Short Story: The 6 Minute TED Talk.
J.S. Reidenberg. Icahn Sch. of Med. at Mount Sinai.
11:10 7.3
Your 15 Minutes on the Podium Have Finally
Arrived...J.T. Laitman. Icahn Sch. of Med. at Mount Sinai.
11:30 7.4
60 Minutes of Tension: The Hour Long
Research Talk. R. Marcucio. UCSF.
11:50 General Discussion.
SATURDAYANATOMY
8.
MORPHOGENESIS AND DIFFERENTIATION OF
CRANIAL NEURAL CREST AND PLACODES
Chaired: S.A. A. Moody
2:15 9.6
Implantation of Insulin-Producing Cells from
Human Umbilical Cord Blood Mesenchymal Stem Cells in
the Liver and Its Potential to Cure Streptozotocin-Induced
Diabetes: An Animal Model Study. M.A. Eladl, M. El-Sherbiny,
A.V. Ranade, H. Gabr. Univ. of Sharjah, United Arab Emirates,
Univ. of Mansoura, Egypt, ALMaarefa Col., Saudi Arabia and
Cairo Univ.
Cell Biology
10.
Symposium
Sat. 1:00 pm—San Diego Convention Center, Room 10
Neurobiology
This session was funded in part by an AAA Three-Year
Research Meetings Outreach Grant
1:00 8.1
Complex Roles of ADAM Cell Surface
Metalloproteases during Cranial Neural Crest Cell Migration.
D. Alfandari, G. Abbruzzese, K. Mathavan, H. Cousin. Univ.
of Massachusetts Amherst.
1:30 8.2
Self-Organization of Zebrafish Lateral Line
Primordium Morphogenesis and Migration. A. Chitnis, D. Dalle
Nogare. NICHD, NIH.
2:00 8.3
Neural Crest-Placode Cell Interactions during
Cranial Ganglia Assembly. L.A. Taneyhill. Univ. of Maryland
College Park.
9.
STEM CELLS AND TISSUE ENGINEERING
PLATFORM
Platform
Chaired: M. Dunnwald
Stem Cells/ Regeneration
Tissue Bioengineering
This session is part of the Stem Cells Mini-Meeting
1:00 9.1
TGFβ Signaling Regulates Decorin and
Biglycan Expression and Distribution during Murine Palatal
Fusion. K.K.H. Svoboda, I. Ibrahim, M.J. Serrano, L-B.
Ruest. Texas A&M Baylor Col. of Dent.
1:15 9.2
Matrix Reloaded: Devitalized Cartilage as a
Functional Extracellular Niche to Promote Osteogenesis and
Angiogenesis. J.M. Perry, D.M. Poscablo, B.T. Gaston, D.P.
Hu, T. Miclau, K.L. Christman, R.S. Marcucio, C.S. Bahney.
UCSF and UCSD.
1:30 9.3
Impact of BMP-7 on Cell Migration in the
Meniscus. V. Taylor II, I. Hutchinson, K. Danelson, C.
Ferguson. Wake Forest Med. Ctr. and Hosp. for Spec. Surg.,
NY. (1034.17)
1:45 9.4
Potential Mechanisms of Action for Exogenous
Ketone Enhancement of Ischemic Wound Healing in Young
and Aged Fischer Rats. S.L. Kesl, M. Wu, L.J. Gould, D.P.
D’Agostino. Morsani Col. of Med., Univ. of South Florida.
(1036.9)
2:00 9.5
Characterization
of
Spontaneous
Chondrogenesis during Tail Regeneration of the Leopard Gecko
(Eublepharis macularius). N. Subramaniam, K. Jacyniak, R.P.
McDonald, M.K. Vickaryous. Univ. of Guelph, Canada.
BUILDING THE FUTURE OF HISTOLOGY:
SYNERGY BETWEEN EDUCATORS, CLINICIANS
AND TECHNOLOGY
Hybrid Symposium
Chaired: R. Ettarh
Education and Teaching
1:00 10.1
Building LCME-Compliant Histology Teaching
and Learning for Clinicians. R. Ettarh. Tulane Univ. Sch.
of Med.
1:30 10.2
Integrating Histology in the Medical Curriculum.
D. Bolender. Med. Col. of Wisconsin.
2:00 10.3
Collaboration between Basic Scientists
and Clinicians: An Opportunity to Develop a Microanatomy
Curriculum to Integrate Curricular Content and Encourage
Student Interaction. J.M. McBride. Lerner Col. of Med.,
Cleveland Clin.
2:15 10.4
The Interrupted Learner – How Students’
Choices to Attend Lectures or Watch Lecture Video Recordings
Influence Learning Outcomes in a Medical Histology Course.
M. Hortsch, J. Burk-Rafel, A.H. Zureick, J. Purkiss. Univ.
of Michigan.
11.
BIOLOGICAL ANTHROPOLOGY PLATFORM
Platform
Sat. 1:00 pm—San Diego Convention Center, Room 7B
Chaired: K. Willmore
Evolution/Anthropology
Developmental Biology/Morphology
Emily Middleton is competing as a finalist in the Postdoctoral
Platform Presentation Award
1:00 TBD
1:15 11.2
Reconstructing Jaw Adductors in Plesiadapid
Plesiadapiforms from Berru, France (Thanetian, ELMA). H.
Kristjanson, J.M.G. Perry. Johns Hopkins Univ. Sch. of Med.
1:30 11.3
2D versus 3D Shape Signals of Climatic
Adaptations in the Trunk Skeleton of Recent Humans. E.R.
Middleton. Univ. of Missouri-Columbia.
1:45 11.4
New Insights into the Anatomy of the
Bulbospongiosus Muscle and Its Role in the Composition of the
External Anal Sphincter in Humans. M. Hall, J.H. Plochocki, B.
Adrian, J.R. Rodriguez-Sosa. Midwestern Univ., AZ.
2:00 11.5
Getting the Shaft?: Investigating Midshaft
Location in Immature Femora. C.D. Eleazer, R. Scopa Kelso,
F.L. West, L. Williams, R. Stradleigh, A. Shaeffer. Florida
Intl. Univ., West Virginia Sch. of Osteo. Med. and Univ. of
Tennessee, Knoxville.
3
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ANATOMY 2:15 11.1
A Comparative and Phylogenetic Analysis of
the Relationship between Facial Orientation and Circumorbital
Breadths in the Hominoids. E. Leslie, Y. Mehta. Midwestern
Univ., IL.
12.
SATURDAY
14.
ALTERNATIVE PRESERVATION TECHNIQUES
TO MEET THE NEEDS OF TODAY’S STUDENTS
Symposium
SENSATION MECHANISM OF BODY FLUID
FLOW BY PRIMARY CILIA
Chaired: M. Sochor
Symposium
Chaired: T. Inoue
Cell Biology
3:00 12.1
In Vivo Analysis of Cilia Function and
Connections to Renal Disease and Physiology. B.K. Yoder.
Univ. of Alabama at Birmingham.
3:30 12.2
Primary Cilia of Inner Ear Hair Cells Do Not
Respond to Mechanical Stimuli. A.A. Indzhykulian, M. Delling,
X. Liu, Y. Li, T. Xie, D.P. Corey, D.E. Clapham. Harvard Med.
Sch. and Boston Children’s Hosp.
4:00 12.3
The Integration of Mechanobiology and
Biomechanics at Primary Cilia. C.R. Jacobs, A. Nguyen.
Columbia Univ.
13.
3:00 14.1
Pride,
Protectionism,
and
Prejudice
Overcoming Hurdles in Setting-Up Pilots to Evaluate “Fix
for Life”, a Low-Hazardous Embalming Method Preserving
Life-Like Morphology. A.J. Van Dam. Leiden Univ. Med.
Ctr., Netherlands.
3:30 14.2
Preparation of an Anatomical Donor Using
the Sikon Soft-Cure Method. R.R. Sikon. Virginia State Anat.
Donations Prog., Richmond.
4:00 14.3
Evo-Devo Anatomy Dissected: An Approach
Using Soft Embalming That Transforms the Regional-versusSystemic Debate. N.T. Boaz, R.L. Bernor, K. Meshida. Col. of
Henricopolis Sch. of Med., VA and Howard Univ. Col. of Med.
15.
SKIN DEEP: STRUCTURE AND FUNCTION
OF OSTEODERMS
Symposium
FUTURE MEDICINE: THE IMPACT OF
3D PRINTING
Chaired: T. Owerkowicz
Symposium
Chaired: D. Mills
3:00 13.1
3D Bioprinting Nanocomposite Scaffolds
for Complex Tissue Regeneration. G. Zhang. George
Washington Univ.
3:30 13.2
Novel Method for the 3D Printing of Bioactive
Biomedical Devices. J.A. Weisman, U. Murthy, K. Tappa, D.K.
Mills. LSU Hlth. Sci. Cr., Shreveport and Louisiana Tech Univ.
4:00 13.3
3D Printing of Customized Implants for
Treatment of Orofacial Deformities and Defects. L. Tayebi.
Marquette Univ. Sch. of Dent.
3:00 15.1
Fortified Frogs and Skeletogenesis in the Skin:
Osteoderm Development and Structure across Tetrapods.
M.K. Vickaryous, E.A.B. Gilbert, S.L. Delorme. Univ. of
Guelph, Canada.
3:30 15.2
Bone as a Buffer: Consequences for Vertebrate
Design and Anaerobic Physiological Performance. D. Warren.
Saint Louis Univ.
4:00 15.3
Heat Transfer through Skin with and without
Osteoderms in the American Alligator. T. Owerkowicz.
California State Univ., San Bernardino.
16.
WELCOME AND KEYNOTE SPEAKER
Keynote Lecture
Regenerative Medicine (Stem Cells, Tissue
Regeneration, Biomaterials)
Are You Tweeting about
EB 2016?
To Tweet use #expbio
Be sure to follow EB on
Facebook and Twitter.
4
Welcome and introduction by AAA President, Kimberly Topp
4:45
4:50
New Insights into Stem Cells in Mammary Development
and Breast Cancer. Z. Werb. UCSF.
SATURDAYBIOCHEMISTRY
17.
ASBMB PROFESSIONAL DEVELOPMENT
PROGRAM FOR GRADUATE STUDENTS AND
POSTDOCTORAL TRAINEES
21.
Special Event
Special Session
Invitation only. Required participation by all Graduate/
Postdoctoral and Underrepresented Graduate Student Travel
Award recipients.
18.
S
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Sat. 8:30 am—San Diego Convention Center, Room 6A
Cochaired: C. Heinen and T. O’Connell
ASBMB 20TH ANNUAL UNDERGRADUATE
STUDENT RESEARCH POSTER COMPETITION
Cochaired: K. Cornely, K. Fox and P. Ortiz
Pre-registration required. Check-in and set-up begin
at Noon.
22.
BUILDING YOUR OUTREACH PROGRAM FROM
A TO Z
ASBMB PROFESSIONAL DEVELOPMENT
PROGRAM WORKSHOPS FOR GRADUATE
STUDENTS AND POSTDOCTORAL TRAINEES
Workshop
Sat. 2:30 pm—Locations (multiple)
Workshop
Pathways to Your Own Lab
San Diego Convention Center, Room 1A
Sat. 9:00 am—San Diego Marriott Marquis & Marina Hotel,
San Diego Ballroom C
Implementing Your IDP
San Diego Convention Center, Room 1B
Advance event registration required.
Learn how to start, expand or improve your own public
engagement program.
Taking the Industrial Route
San Diego Convention Center, Room 6D
Follow the conversation: #scicomm
19.
ASBMB UNDERGRADUATE STUDENT ANNUAL
MEETING ORIENTATION
23.
ASBMB EXPLORING CAREERS SPEEDNETWORKING EVENT
Special Session
Workshop
Sat. 4:30 pm—San Diego Convention Center, Room 6A
Orientation open to all undergraduates attending the poster
competition. No registration required.
Undergraduates learn about a variety of exciting career
options in this fun and fast-paced workshop.
20.
24.
COMMUNICATION WORKSHOP: MAKE YOUR
ELEVATOR PITCH
Workshop
Sat. 12:30 pm—San Diego Marriott Marquis & Marina
Hotel, San Diego Ballroom C
ASBMB BUSINESS MEETING
Business Meeting
Sat. 6:00 pm—San Diego Convention Center,
Ballroom 20BC
5
BIOCHEMISTRY/NUTRITIONSATURDAY
25.
ASBMB OPENING LECTURE: HERBERT TABOR
RESEARCH AWARD LECTURE
26.
ASBMB OPENING RECEPTION
Special Event
Award Lecture
Sat. 7:30 pm—San Diego Convention Center, Sails Pavilion
Ballroom 20BC
Follow the conversation: #bigtalks
6:00
Awardee introduction.
6:45 25.1
Eukaryotic Transcription Mechanisms: From
Nuclear RNA Polymerases to General Initiation Factors, GeneSpecific Activators, Coactivators and Chromatin. R.G. Roeder.
The Rockefeller Univ.
Immediately follows the ASBMB Opening Lecture. ASBMB
members and biochemistry attendees welcome. Science
Outreach and ASBMB Student Chapter Activity Posters will be
presented during the reception for attendees to explore and
become inspired.
27.
ASBMB SCIENCE OUTREACH AND STUDENT
CHAPTERS ACTIVITY POSTERS
Poster Discussion
Science Outreach and ASBMB Student Chapter Activity
Posters will be featured during the ASBMB Opening Reception.
All posters presented at 7:30 PM.
Follow the conversation: #scicomm
Nutrition
28.
NUTRITIONAL SCIENCES COUNCIL BUSINESS
MEETING AND BREAKFAST
Business Meeting
Sat. 7:00 am—San Diego Convention Center, Room 28D/E
29.
BIG DATA AND INNOVATIVE APPROACHES
TO UNDERSTANDING DIETARY PATTERNS
AND HEALTH
30.
CLINICAL EMERGING LEADER AWARD
ORAL COMPETITION
Symposium
Award Competition
(Sponsored by: International Life Sciences Institute,
North America)
Sat. 9:00 am—San Diego Convention Center, Room 33BC
Sat. 8:30 am—San Diego Convention Center, Ballroom 20D
Chaired: B.O. Schneeman
Cochaired: B.D. Flickinger
Nutritional Epidemiology
8:30 Welcome and Introduction by Session Chairs.
B. Scheeman, B. Flickinger. USAID, Archer
Daniels Midland.
8:40
Dietary Patterns and Health Outcomes: A Review. R.
Bailey. Purdue Univ.
9:10 Vision for the Future: Big Data and Innovative
Approaches to Studying Dietary Patterns and Health/
Disease. B. Lee. Johns Hopkins Bloomberg Sch. of
Publ. Hlth.
9:40
Case Study I: Applying Big Data Approaches to Study
Food and Diet Patterns on Health Markers. J.
Ordovás. USDA at Tufts Univ.
10:10Break.
6
10:30 Case Study II: USDA FoodAPS: Examining Food
Assistance Programs. M. Denbaly. USDA Econ.
Res. Svc.
11:00 How to Apply Big Data and Analytics to Food Intake
Measures at Population and Individual Levels. S.
Intille. Northeastern Univ.
11:30 Panel Discussion.
Chaired: C.W. Bales
9:00Introduction.
9:15 Effects of Polyphenolic-Rich Dark Chocolate and
Almonds on Cardiovascular Risk Factors in
Overweight and Obese Adults. Y. Lee, C. Berryman,
S. West, C-Y.O. Chen, J. Blumberg, A. Preston, K.
Lapsley, J. Fleming, P. Kris-Etherton. Penn State,
USDA at Tufts Univ., Hershey Co., PA and Almond Bd.
of California, Modesto. (293.1)
9:30 Higher Protein Intake Improves Sleep and Blood
Pressure, and Influences the Relation between
Changes in Blood Pressure and Sleep during Energy
Restriction in Middle-Aged Overweight and Obese
Adults. J. Zhou, J.E. Kim, W.W. Campbell. Purdue
Univ. (415.6)
10:00 Impact of Body Mass Index and Metabolic Health Status
on All-Cause Mortality Risk among Older Adults. F.W.
Cheng, X. Gao, D.C. Mitchell, C. Wood, C. Still, G.L.
Jensen. Penn State and Geisinger Obesity Inst.,
Danville, PA. (417.1)
SATURDAYNUTRITION
10:15 Effects of Dietary Protein and Fiber at Breakfast on
Postprandial Appetite, Neural Responses to Visual
Food Stimuli, and Ad Libitum Energy Intake at Lunch
in Overweight Adults. R.D. Sayer, A. Amankwaah,
G. Tamer; Jr, N. Chen, A. Wright, J. Tregellas, M.
Cornier, D. Kareken, T. Talavage, M. McCrory, W.
Campbell. Weldon Sch. of Biomed. Engin., Purdue
Univ., Univ. of Colorado Sch. of Med., Anschutz Med.
Campus, Indiana Univ. Sch. of Med. and Georgia
State Univ. (418.7)
10:30 Impact of Maternal Infection and Breast Inflammation
on Infant Growth in Guatemala. H.M. Wren, A.L.
Leblanc, C. Li, N.W. Solomons, M.E. Scott, K.G.
Koski. McGill Univ., St-Anne-de-Bellevue, Montreal
and CeSSIAM, Guatemala City. (45.6)
31.
POSTDOCTORAL RESEARCH AWARD
ORAL COMPETITION
Award Competition
Sat. 9:30 am—San Diego Convention Center, Room 32AB
9:30Introduction.
9:40 HIV-Infected Pregnant and Lactating Women Have
Higher Serum Aflatoxin Levels Than HIV-Uninfected
Women and Aflatoxin Levels Are Higher during Early
Postpartum Than during Pregnancy among HIVInfected Women. B.K. Natamba, J-S. Wang, S.L.
Young, S. Ghosh, J.K. Griffiths. Harvard Univ., Gulu
Univ., Uganda, Univ. of Georgia, Cornell Univ. and
Tufts Univ. (668.5)
10:00 Formula Milk Alters Microbial Diversity in Porcine Colon
and Impacts Immune Response. M.K. Saraf, A.K.
Bowlin, S.V. Chintapalli, K. Shankar, T. LeRoith,
M.J. Ronis, T.M. Badger, L. Yeruva. Arkansas
Children’s Nutr. Ctr., Univ. of Arkansas for Med. Sci.,
VA-MD Col. of Vet. Med. and LSU Hlth. Sci. Ctr., New
Orleans. (406.8)
10:20 Hepcidin Attenuates Zinc Efflux in Caco-2 Cells. S.R.
Hennigar, J.P. McClung. U.S. Army Res. Inst. of
Envrn. Med., Natick, MA. (292.3)
10:40 A Plasma Proteome Is Associated with Anthropometric
Status in School-Aged Children in Nepal. S.E. Lee,
P. Christian, K. Schulze, R.N. Cole, L.S.F. Wu,
J.D. Yager, J. Groopman, C.P. Stewart, K.P. West;
Jr. Johns Hopkins Bloomberg Sch. of Publ. Hlth.,
Johns Hopkins Sch. of Med. and Univ. of California,
Davis. (432.2)
11:00Trimethylamine-N-Oxide Biomarker Response Is
a Function of Dietary Precursor Intake and Gut
Microbiota Composition in Healthy Young Men. C.E.
Cho, S. Taesuwan, O.V. Malysheva, E. Bender, N.F.
Tulchinsky, J. Yan, J.L. Sutter, M.A. Caudill. Cornell
Univ. (406.6)
11:20 Trace Element Distribution in Flatiron Mice, a Genetic
Model of Human Ferroportin Disease. Y.A. Seo,
M. Wessling-Resnick. Harvard Sch. of Publ.
Hlth. (292.7)
11:40Conclusion.
32.
OBESITY, IRON METABOLISM DYSFUNCTION
AND CHRONIC DISEASE
Symposium
Sat. 10:30 am—San Diego Convention Center, Room
31ABC
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Chaired: L. Tussing-Humphreys
Cochaired: N. Gletsu-Miller
Cellular and Molecular Nutrition
10:30 Systemic Iron Regulation in Health and Disease. E.
Nemeth. UCLA.
10:55 Novel Targets in Obesity and Diabetes: The Role of
Iron and Hypoxia in the Regulation of Appetite and
Metabolism. D. McClain. Wake Forest Univ. Sch.
of Med.
11:20 Macrophage Iron Handling in Health and Disease. A.
Hasty. Vanderbilt Univ. Sch. of Med.
11:45 Brain Iron Accumulation, Insulin Resistance and
Cognition in Obese Adults. J-M. Fernandez-Real.
Hosp. of Girona “Dr. Josep Trueta”
33.
GLOBAL NUTRITION: OVERWEIGHT, OBESITY
AND NUTRITION TRANSITION
Minisymposium
(Sponsored by: Global Nutrition Council)
Chaired: TBD
Cochaired: M. Garcia Meza
10:30 33.1
Recommended Anthropometric Cut-Offs for
Population Screening of Diabetes and Pre-diabetes Need
to Be Evaluated in Resource-Limited Settings. E.A. Yu, J.L.
Finkelstein, W. Bonam, M.J. Glesby, P.M. Brannon, S. Mehta.
Cornell Univ., Arogyavaram Med. Ctr., Andhra Pradesh, India
and Weill Cornell Med. Col.
10:45 33.2
Early Childhood Predictors of Lifecourse BMI
Latent Class Trajectories in a Guatemalan Cohort. N.D. Ford,
M. Ramirez-Zea, R. Martorell, A.D. Stein. Emory Univ. and Inst.
of Nutr. of Central America and Panama (INCAP), Guatemala.
11:00 33.3
Stunting and Its Relationship to Obesity in the
U.S. Affiliated Pacific: A Study of the Children’s Healthy Living
Program. R. Novotny, F. Li, R. Leon Guerrero, P. Coleman,
T. Fleming, A. Bersamin, J. Deenik, L.R. Wilkens. Univ. of
Hawaii, Mangilao, Guam, Saipan, No. Mariana Islands, Pago
Pago, American Samoa and Fairbanks, AK.
11:15 33.4
Height, Weight and Body Mass Index in Lowand Middle-High-Income Urban Preschoolers in the Western
Highlands of Guatemala. M.R. García-Meza, C.M. Doak,
J.J.S. Beintema, M.N. Orozco, R. Gwaltney, H.B. Rolker,
N.W. Solomons. CeSSIAM Quetzaltenango, Guatemala, VU
Amsterdam and CeSSIAM, Guatemala City.
11:30 33.5
Parenting Behaviors and Weight Status of
Junior High School Students in China. Z. Tian, M. Wen, W.
Wang, H. Xue, J. Min, Y. Wang. Univ. at Buffalo, SUNY, Univ.
of Utah and Renmin Univ of China, Beijing.
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NUTRITIONSATURDAY
11:45 33.6
Protein Intake, Breastfeeding Frequency
and Breastfeeding Duration Affect BMI from Infancy to Mid
Childhood. M. Wright, D. Sotres-Alvarez, M. Mendez, L.
Adair. Univ. of North Carolina at Chapel Hill.
12:00 33.7
Development and Evaluation of a Food Behavior
Survey to Assess Nutrition Transition among Adolescents in
South India. N. Shaikh, S. Patil, U. Ramakrishnan, K. Yount,
S. Cunningham. Emory Univ. and BLDE Univ., India.
12:15 33.8
Low Plasma Concentrations of High-Density
Lipoprotein Cholesterol Associated with Shorter Duration of
Pregnancy: A Nested Cohort Study in Ghana. B.M. Oaks,
C.P. Stewart, K.D. Laugero, S. Adu-Afarwuah, A. Lartey,
S.A. Vosti, P. Ashorn, K.G. Dewey. Univ. of California, Davis,
USDA, Davis, Univ. of Ghana and Univ. of Tampere Sch. of
Med., Finland.
34.
CARIG: CAROTENOID AND RETINOID:
MOLECULAR MECHANISMS OF ACTION
Minisymposium
(Sponsored by: CARIG RIS)
Sat. 10:30 am—San Diego Convention Center, Room 30C
Chaired: E. Johnson
Cochaired: L. Jahns
10:30 34.1
Dietary Tomato Powder Inhibits Hepatic
Steatosis, Inflammation and Tumorigenesis in BetaCarotene-15, 15’-Oxygenase (BCO1) and Beta-Carotene-9,
10’-Oxygenase (BCO2) Double Knockout Mice. C-C. Li, C. Liu,
K. Hu, D.E. Smith, J. von Lintig, X-D. Wang. USDA at Tufts
Univ.and Sch. of Med., Case Western Reserve Univ.
10:45 34.2
Lutein, but Not Other Carotenoids, Selectively
Inhibits Breast Cancer Cell Growth through Several Molecular
Mechanisms. H.M. Swanson, J.R. Smith; Jr., X. Gong, L.P.
Rubin. Paul L. Foster Sch. of Med., Texas Tech Univ. Hlth. Sci.
Ctr. and Univ. of Texaas El Paso.
11:00 34.3
Astaxanthin Attenuated the Expression of
Fibrogenic Genes Induced by High Glucose Alone and in
Combination with Transforming Growth Factor 1β in Hepatic
Stellate Cells. M. Bae, J-Y. Lee. Univ. of Connecticut.
11:15 34.4
All-trans-Retinoic Acid Inhibits Adipogenesis
by Interrupting Gadd45α-Induced Zfp423. B. Wang, M. Zhu, M.
Du. Washington State Univ.
11:30 34.5
Vitamin A Supplementation Only Transiently
Increases Retinol Concentrations in Extrahepatic Organs of
Neonatal Rats Raised under Vitamin A-Marginal Conditions.
J.K. Urbanek, L. Tan, M.H. Green, A.C. Ross. Penn State and
Univ. of Alabama.
11:45 34.6
SNPs in Lipid and Carotenoid Metabolism and
Absorption Genes Impact Carotenoid Responses to a TomatoSoy Juice Intervention. N.E. Moran, J.M. Thomas-Ahner,
J.L. Fleming, J.P. McElroy, E.M. Grainger, K.M. Riedl, S.J.
Schwartz, S.K. Clinton. The Ohio State Univ.
12:00 34.7
Metabolomic Profile of Serum Retinol
Concentrations in the ATBC Study Cohort. D. Albanes, O.
Panagiotou, S. Weinstein, S. Moore, A. Mondul. NCI, NIH
and Univ. of Michigan Sch. of Publ. Hlth.
8
13
12:15 34.8
C Natural Abundance of Serum Retinol Is a
Novel Biomarker for Evaluating Effectiveness of Provitamin A
Biofortified Maize and Carrots in Male Mongolian Gerbils. B.M.
Gannon, I. Pungarcher, L. Mourao, C.R. Davis, P.M. Simon,
K.V. Pixley, S.A. Tanumihardjo. Univ. of Wisconsin-Madison
and Intl. Maize and Wheat Improvement Ctr., El Batan, Mexico.
35.
ASN YOUNG MINORITY INVESTIGATOR
ORAL COMPETITION
Award Competition
(Organized by: the ASN Minority and Diversity
Affairs Committee)
Sat. 11:30 am—San Diego Convention Center, Room 33BC
Chaired: M.D. Teran-Garcia
11:30
11:45
Overview and Introduction. M.D. Teran-Garcia.
DHA Status is Related to Prefrontal Cortex-Mediated
Impulse Control in Adolescents. V. Darcey.
Georgetown Univ. (407.3)
12:00 Association of Vitamin D Status with Dual Task Physical
Performance in Older Adults. J. Lopez. Florida Intl.
Univ. (917.14)
12:15 Maternal Plasma Folate, Vitamin B12 Levels and
Multivitamin Supplementation during Pregnancy and
Risk of Autism Spectrum Disorder in the Boston Birth
Cohort. R. Raghavan. Johns Hopkins Bloomberg
Sch. of Publ. Hlth. (151.6)
12:30 Molds Attack Rice, but We Don’t Know What to Do. A
Qualitative Study of Farming Families’ Perceptions
of Food Safety in Banke, Nepal. J.A. Chavez. Tufts
Univ. (891.10)
12:45 Mango Supplementation Prevents Gut Microbial
Dysbiosis and Modulates Short Chain Fatty Acid
Production Independent of Body Weight Reduction in
C57BL/6 Mice Fed a High Fat Diet. B. Ojo. (1166.6)
36.
ASN SPONSORED SATELLITE PROGRAM:
PULSES FOR HEALTHY PEOPLE AND A
HEALTHY PLANET: EMERGING RESEARCH
AND OPPORTUNITIES
ASN Satellite
(Organized and Sponsored by: the US Dry Pea and Lentil
Council, Pulse Canada, World Food Center at University
of California, Davis
and the American Pulse Association)
Sat. 12:45 pm—San Diego Convention Center, Room 33BC
For more information on ASN Sponsored Satellite
Programs, please visit http://scientificsessions.nutrition.org
/satellitesessions/.
SATURDAYNUTRITION
38.
PHENHRIG ANNUAL SYMPOSIUM:
FLAVONOIDS/POLYPHENOLS AND
EPIGENETICS: IS THERE A CONNECTION?
2:15
Symposium
(Sponsored by: Plant Phenolic and Human Health
Research Interest Group (PhenHRIG))
Sat. 1:00 pm—San Diego Convention Center, Room 29AB
PHENHRIG information, including speakers, is available
at http://phenhrig.org
39.
GRADUATE STUDENT RESEARCH AWARD
ORAL COMPETITION
2:30
2:45
Award Competition
(Sponsored by: Nutritional Sciences Council)
Sat. 1:00 pm—San Diego Convention Center, Room 29CD
Chaired: C. Davis - GSRA
1:00 Native African Plant Materials Modify In Vitro
Bioaccessibility of Provitamin A Carotenoids from
Blended Cereal Products. H. Debelo, C. Ndiaye, M.
Ferruzzi, B. Hamaker. Purdue Univ. (914.4)
1:15 Adipocyte-Specific Ablation of Long-Chain Acyl-CoA
Synthetase-4 in Mice Protects against Diet-Induced
Obesity-Associated Decreases in White Adipocyte
Oxygen Consumption and Whole Body Energy
Expenditure. E.A. Killion, D. Kong, A.S. Greenberg.
USDA at Tufts Univ. and Tufts Univ. Sackler Sch. of
Grad. Biomed. Sci. (267.8)
1:30 Using a Humanoid Robot along with a Registered
Dietitian in an After-School Program to Promote
Healthy Eating Habits and Physical Activity in SchoolAged Children. N. Mikati, M. Eltoukhy, F. Huffman.
Florida Intl. Univ. and Univ. of Miami. (276.8)
1:45 DHA Is More Potent Than EPA in Attenuating
Cardiometabolic Risk in Men and Women: A
Randomized
Double-Blind,
Placebo-Controlled
Crossover Trial. J. Allaire, P. Couture, A. Charest,
M. Leclerc, J. Marin, M-C. Lépine, A. Tchernof, B.
Lamarche. Univ. Laval and Univ. Inst. of Cardiol. and
Pneumol. of Québec. (130.1)
2:00 MicroRNAs as a Novel Mechanism by Which
Eicosapentaenoic Acid Mediates Inflammation in
Diet-Induced Obesity. E. Yen, N. Wijayatunga, M.
Pahlavani, L. Ramalingam, K.R. Kottapalli, N.S.
Kalupahana, P. Gunaratne, K. Rajapakshe, C.
Coarfa, S. Dharmawardhane, N. Moustaid-Moussa.
Texas Tech Univ., Univ. of Sri Jayewardenepura and
Univ. of Peradeniya, Sri Lanka, Univ. of Houston,
Baylor Col. of Med. and Univ. of Puerto Rico-Med.
Sci. Campus. (911.7)
3:00
3:15
3:30
3:45
40.
Effect of Vitamin D Fortified Cheese on Oral Glucose
Tolerance in Individuals Exhibiting Marginal Vitamin
D Status and an Increased Risk for Developing Type
2 Diabetes: A Double-Blind, Randomized PlaceboControlled Clinical Trial. T.S. Moreira-Lucas, A.M.
Duncan, R. Rabasa-Lhoret, R. Vieth, A. Gibbs, A.
Badawi, T.M.S. Wolever. Univ. of Toronto, Univ. of
Guelph, Canada, Clin. Res. Inst. of Montreal and
Publ. Hlth. Agcy. of Canada, Toronto. (917.1)
Ablation of BCO2 Leads to Increased Susceptibility to
High Fat Diet-Induced Metabolic Disorders in Mice. L.
Wu, X. Guo, A. Davis, T.P. Soh, S. Clarke, E. Lucas,
B. Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma
State Univ., Kansas State Univ. and Univ. of MissouriKansas City. (271.5)
Recommended Anthropometric Cut-Offs for Population
Screening of Diabetes and Pre-diabetes Need to Be
Evaluated in Resource-Limited Settings. E.A. Yu, J.L.
Finkelstein, W. Bonam, M.J. Glesby, P.M. Brannon, S.
Mehta. Cornell Univ., Arogyavaram Med. Ctr., Andhra
Pradesh, India and Weill Cornell Med. Col. (33.1)
Zinc and ZIP14 (Slc39a14) Are Required for Adaptation
to ER Stress in Mouse Liver. M-H. Kim, T.B. Aydemir,
R.J. Cousins. Univ. of Florida. (148.2)
Household Food Insecurity Access Scale and Household
Food Insecurity Access Prevalence as Predictor
of Stunted Child and Overweight/Obese Mother in
Urban Indonesia. T. Mahmudiono, D.R. Andrias, T.S.
Nindya, H. Megatsari, R. Rosenkranz. Kansas State
Univ. and Univ. Airlangga, Indonesia. (273.8)
Serum Bone-Building Metabolites Are Enhanced by a
Restricted Vitamin A Intervention in Zambian Children
with High Liver Reserves of Vitamin A. K.E. Olsen, N.
Binkley, B.M. Gannon, S.A. Tanumihardjo. Univ. of
Wisconsin-Madison. (678.24)
Depletion of Dietary MicroRNAs from Cow’s Milk Causes
an Increase of Purine Metabolites in Human Body
Fluids and Mouse Livers. A.G. Aguilar Lozano, S.
Baier, J. Adamec, M. Sadri, D. Giraud, J. Zempleni.
Univ. of Nebraska-Lincoln. (127.1)
SEX AND METABOLISM: LATE BREAKING
RESEARCH ON THE ROLE OF ESTROGEN
RECEPTORS IN CARDIOMETABOLIC HEALTH
Symposium
(Sponsored by: Energy and Macronutrient
Metabolism RIS)
Sat. 3:00 pm—San Diego Convention Center, Ballroom 20D
Chaired: V.J. Vieira-Potter
3:00
3:25
3:50
Estrogen, Metabolism and Energy Homeostasis Brain-related mechanisms. D. Clegg. Cedars-Sinai
Diabetes and Obesity Res. Inst.
Estrogen Signaling and Insulin-mediated Glucose Uptake
after Menopause: “Timing Hypothesis” Revisited. R. Van
Pelt. Univ. of Colorado Anschutz Med. Campus.
Estrogen Signaling and Vascular Endothelial Function
with the Menopause Transition. K. Moreau. Univ. of
Colorado Anschutz Med. Campus.
9
S
A
T
NUTRITIONSATURDAY
4:15
41.
Effects of Estrogen Receptor Alpha Signaling on
Immunometabolism. A. Hevener. UCLA.
DIETARY FIBER’S ESSENTIALITY FOR THE
INTESTINE AND THE MICROBIOTA
Symposium
Sat. 3:00 pm—San Diego Convention Center, Room 31ABC
Chaired: D.T. Gordon
Cochaired: D.M. Klurfeld
Clinical and Translational Nutrition
3:00
3:25
3:50
42.
Mucosal Atrophy and other Intestinal Dysfunctions
with Total Parenteral Nutrition and Limited Enteral
Nutrition. TBD.
Dietary Fiber, Gut Microbiota and Immune Response. C.
MacKay. Charles Perkins Ctr.-Sydney Med. Sch.
Contributions of Gut Microbiota to Health Benefits of
Dietary Fiber. V. Mai. Univ. of Florida.
DIET AND CANCER: POPULATIONAL AND
MOLECULAR STUDIES OF BREAST AND
COLON CANCER
Minisymposium
(Sponsored by: Diet and Cancer RIS)
Chaired: E. Park
Cochaired: K. Ferrini
3:00 42.1
Consumption of Total and Individual Sugars,
Sugary Foods and Sugary Beverages in Relation to AdiposityRelated Cancer Risk in the Framingham Offspring Cohort
(1991-2013). N. Makarem, Y. Lin, E.V. Bandera, P. Jacques,
N. Parekh. NYU, Rutgers Univ. and USDA at Tufts Univ.
3:15 42.2
Four a priori-Defined Diet Quality Indexes and
Survival among Men and Women with Colorectal Cancer: The
Multiethnic Cohort. G. Maskarinec, S. Jacobs, B.E. Harmon,
L.R. Wilkens, L. Le Marchand, L.N. Kolonel, C.J. Boushey.
Univ. of Hawaii and Univ. of Memphis Sch. of Publ. Hlth.
3:30 42.3
Dietary Phytosterols Intakes Are Inversely
Associated with Colorectal Cancer Risk among Chinese
Population. C-X. Zhang, J. Huang, M. Xu, W-P. Luo, Y-J. Fang.
Sch. of Publ. Hlth. and Cancer Ctr., Sun Yat-sen Univ., China.
3:45 42.4
Dietary Carotenoid, Retinol, and Ascorbic
Acid Intake and Its Association with Breast Density in Young
Women. J.N. Bodor, S. Jung, C. Klifa, L. Van Horn, J.F.
Dorgan. Univ. of Maryland Med. Ctr., Univ. of Maryland Sch.
of Med., Dangeard Group, Luynes, France and Northwestern
Univ. Feinberg Sch. of Med.
4:00 42.5
Effect of 1,25(OH)2D in Regulating GlutamicOxaloacetic Transaminase 1 and Redox Balance during Breast
Cancer Progression. X. Zhou, T. Wilmanski, D. Teegarden.
Purdue Univ.
4:15 42.6
Reversal
Effects
of
Genistein
and
(-)-Epigallocatechin-3-Gallate on Repression of BRCA-1
Expression in Human Breast Cancer Cells with Activated
AhR. O.I. Selmin, A.J. Papoutsis, D.F. Romagnolo. Univ.
of Arizona.
10
4:30 42.7
Effect of Short-Chain Fatty Acid Acetate
on Colon Cancer. M. Sahuri Arisoylu, J.D. Bell. Univ. of
Westminster, U.K.
4:45 42.8
Inactivation of Pyruvate Dehydrogenase
Complex Mediates the Selective Effects of Butyrate on
Colorectal Cancer Cells. A. Han, N. Bennett, A. MacDonald,
M. Johnstone, J. Whelan, D.R. Donohoe. Univ. of
43.
NUTRITIONAL EPIDEMIOLOGY: INNOVATION
AND VALIDATION OF DIETARY ASSESSMENT
TOOLS AND THEIR APPLICATIONS
Minisymposium
(Sponsored by: Nutritional Epidemiology RIS)
Chaired: C.J. Boushey
Cochaired: S. Sahni
3:00 43.1
Method of Assessing Daily Intake-Frequencies
for Major Food Groups Using Dietary Screener Data. E.
Calloway, T. Smith, C. Pinard, A. Oh, L. Nebeling, E.
Hennessy, A. Yaroch. Gretchen Swanson Ctr. for Nutr.,
Omaha and NCI, NIH.
3:15 43.2
The ASA24-Kids-2014 versus Traditional 24Hour Diet Recall for Assessing Dietary Intake of Adolescents.
S. Summer, A. Hughes, L. Benken, N. Ollberding, H.J.
Kalkwarf. Cincinnati Children’s Hosp. Med. Ctr.
3:30 43.3
A Validation of Automated Self-Administered
24-Hour Dietary Recalls Relative to Interviewer-Administered
Recalls Using the Nutrition Data System for Research. D.C.
Mitchell, F.W. Cheng, C.D. Still, G.L. Jensen. Penn State and
Geisinger Hlth. Syst., Danville, PA.
3:45 43.4
Use of Skin Carotenoids as a Biomarker for
Fruit and Vegetable Intake among Mexican-Origin Children in a
Community Setting. A.L. Aguilera, A. de la Torre, L.L. Kaiser.
Univ. of California, Davis.
4:00 43.5
The Breath Carbon Isotope Ratio Is a
Promising Biomarker of Added Sugar Intake. D.M. O’Brien,
J.A. Black, K. Niles, D. Schoeller. Univ. of Alaska Fairbanks
and Univ. of Wisconsin-Madison.
4:15 43.6
Development and Validation of Empirical
Indices of Dietary Insulinemic Potential. F.K. Tabung, W. Wang,
T.T. Fung, F.B. Hu, S. Smith-Warner, J.E. Chavarro, W.C.
Willett, E.L. Giovannucci. Harvard T.H. Chan. Sch. of Publ.
Hlth., Simons Col. and Harvard Med. Sch.
4:30 43.7
Development and Validation of a Nutrition
Transition Diet Score for Adolescents in India. N. Shaikh, U.
Ramakrishnan, S. Patil, K. Yount, R. Martorell, K.M. Venkat
Narayan, S. Cunningham. Emory Univ. and BLDE Univ., India.
4:45 43.8
Evaluation of Dietary Assessment Tools: Does
‘Validated’ Mean What We Think It Means? S.I. Kirkpatrick,
A.F. Subar, S.M. Krebs-Smith, F.E. Thompson, J. Reedy, T.E.
Schap, L. Vanderlee, P. Robson, I. Csizmadi, B.A. Boucher,
I. Massarelli, I. Rondeau. Univ. of Waterloo, Canada, NCI,
NIH, USDA, Alexandria, VA, Alberta Hlth. Svcs., Edmonton and
Calgary, Cancer Care Ontario and Hlth. Canada, Ottawa.
SATURDAYNUTRITION
44.
GLOBAL NUTRITION: NUTRITIONAL
DEFICIENCY – PREVALENCE
AND CONSEQUENCES
45.
MATERNAL, PERINATAL AND PEDIATRIC
NUTRITION: MATERNAL FACTORS RELATED TO
PREGNANCY, LACTATION AND INFANT HEALTH
Minisymposium
Minisymposium
Maternal, Perinatal and Pediatric Nutrition RIS
Sat. 3:00 pm—San Diego Convention Center, Room 30C
Chaired: P. Christian
Chaired: C. Lovelady
Cochaired: E. Widen
3:00 44.1
Is There an Increased Risk of Iodine Deficiency
among Reproductive-Age Women (18-45) with “Normal”
Thyroid Function? P. Panth, N.M. DiMarco, L.J. Petterborg.
Texas Woman’s Univ.
3:15 44.2
The Sensitivity and Specificity of Thyroglobulin
as an Index of Iodine Status in Mildly Iodine Deficient Adults.
S.A. Skeaff, Z.F. Ma. Univ. of Otago, New Zealand.
3:30 44.3
Vitamin B12 Status in Pregnant Women
and Their Infants in Southern India. J.L. Finkelstein, P.
Dwarkanath, S. Mehta, T. Thomas, A.V. Kurpad. Cornell Univ.
and St. John’s Res. Inst., Bangalore.
3:45 44.4
Association of Early Nutrition Deficit with Early
Childhood Development in Children 36 to 59 Months within
and across Populations in Low- and Middle-Income Countries.
L.I. Reyes, E.A. Frongillo, S. Kulkarni, S. Basnet, F. de
Castro. Univ. of South Carolina and Mexico Natl. Inst. of Publ.
Hlth., Cuernavaca.
4:00 44.5
Determinants of Developmental Milestones
in Infants and Young Children in Bihar, India. L. Larson, R.
Mehta, P. Kekre, P. Verma, M. Young, A. Webb Girard, U.
Ramakrishnan, I. Chaudhuri, S. Srikantiah, R. Martorell.
Emory Univ. and CARE India, Patna.
4:15 44.6
Maternal Vitamin D Status and Adverse
Pregnancy and Neonatal Outcomes in India. J.L. Finkelstein,
C. Duggan, S. Mehta, T. Thomas, K. Srinivasan, A.V. Kurpad.
Cornell Univ., St. John’s Res. Inst., Bangalore, Harvard T.H.
Chan Sch. of Publ. Hlth. and Children’s Hosp. Boston.
4:30 44.7
Path Analyses of 18-Month Language, Motor,
and Executive Function Scores in Malawi. E.L. Prado, P.
Ashorn, U. Ashorn, K. Maleta, J. Sadalaki, C. Stewart, R.
Stewart, S. Vosti, K. Dewey. Univ. of California, Davis, Univ.
of Tampere Sch. of Med., Finland, Univ. of Malawi Col. of Med.
and Univ. of Manchester, U.K.
4:45 44.8
Newly Diagnosed HIV Is Associated with Lower
Rates of Gestational Weight Gain and Loss of Mid-Upper Arm
Circumference among Pregnant Kenyan Women. E.M. Widen,
S. Collins, P. Wekesa, N. Krumdieck, M. Onono, S.L. Young.
Columbia Univ. Med. Ctr., Cornell Univ., Kenya Med. Res. Inst.
and Weill Cornell Med.
S
A
T
3:00 45.1
Calcium Absorption among Racially Diverse
Pregnant Women. M.N.R. Lesser, L. Nguyen, J.C. King, K.O.
O’Brien, E.B. Fung. Children’s Hosp. Oakland Res. Inst., Univ.
of California, Berkeley and Cornell Univ.
3:15 45.2
Trans-Generational Impact of Diet in
Pregnancy: Maternal Dietary Intake of Grains during Pregnancy
and Offspring Growth and Obesity from Birth through Age of
7 Years. Y. Zhu, S.F. Olsen, P. Mendola, F. Hu, C. Zhang.
NICHD, NIH, Rockville, MD, Statens Serum Inst., Copenhagen
and Harvard Sch. of Publ. Hlth.
3:30 45.3
Different Duration of Diet Transitions from
a High-Fat Diet to a Normal-Fat Diet before Pregnancy
Deferentially Affect the Phenotypes of Offspring Obesity with
a Sex-Dependent Manner. Q. Fu, Y. Zhou, H. Xu, P. Olson,
L. Xie. Univ. of North Dakota, Tongji Hosp and Hubei Cancer
Hosp., Wuhan, China and Texas A&M Univ.
3:45 45.4
Association between Breastfeeding, Maternal
Weight Loss and Body Composition at 3 Months Postpartum.
S.A. Elliott, L.C.R. Pereira, E. Guigard, L.J. McCargar, C.C.M.
Prado, R.C. Bell. Univ. of Alberta.
4:00 45.5
Maternal Obesity, 25(OH)D Concentration
and Bone Mineral Density in Breastfeeding Dyads. S. Sen,
A. Penfield-Cyr, Z. Lu, M. Ebeling, B. Hollis, C. Howard, C.
Wagner. Brigham and Women’s Hosp., Med. Univ. of South
Carolina and Rochester Gen. Hosp.
4:15 45.6
Impact of Maternal Infection and Breast
Inflammation on Infant Growth in Guatemala. H.M. Wren,
A.L. Leblanc, C. Li, N.W. Solomons, M.E. Scott, K.G. Koski.
McGill Univ., St-Anne-de-Bellevue, Montreal and CeSSIAM,
Guatemala City.
4:30 45.7
Perceived Breastmilk Insufficiency and HIV
Are Associated with Exclusive Breastfeeding at 1 and 3 Months
among Mothers in Northern Uganda. S.L. Martin, S.M. Collins,
E.M. Widen, D. Achidri, S.L. Young. Cornell Univ., Columbia
Univ. and PRENAPS Uganda, Gulu.
4:45 45.8
The Effect of the Baby Friendly Hospital Initiative
on Exclusive Breastfeeding Rates in Hospitals. J.A. Patterson,
B.H. Olson, N.S. Keuler. Univ. of Wisconsin-Madison.
Enhance Your EB Experience. Download the App!
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11
NUTRITIONSATURDAY
46.
TRANSLATIONAL RESEARCH
AWARD COMPETITION
5:00
Award Competition
(Sponsored by: Nutrition Translation RIS Beachbody and
Tate and Lyle)
5:00
Chaired: M. Braun
3:15Introduction.
3:30
Differences in the Infant Gut Microbiota Related to the
Fatty Acid Composition of Human Milk: Results from
the GEHM Cohort. D.H. Taft, K.A. Dingess, C.J.
Valentine, B.S. Davidson, N.J. Ollberding, D.V.
Ward, J.T. Brenna, R.J. McMahon, A.L. Morrow.
Cincinnati Children’s Hosp. and Med. Ctr., Mead
Johnson Nutr., Glenview, IL, Univ. of Massachusetts
Med. Sch. and Cornell Univ. (406.7)
3:45 Assessing the Public’s Comprehension of Dietary
Guidelines: Perception of Diet Quality Is Inversely
Associated with Dietary ED in U.S. Adults. J.A.
Vernarelli, R. Nouri. Fairfield Univ. (429.7)
4:00
Novel Tool for Discrimination of Feeding Intolerance and
Necrotizing Enterocolitis Risk in the Preterm Infant.
J. Naberhuis, C. Wetzel, K. Tappenden. Baylor Col.
of Med., USDA, Houston, Carle Fndn. Hosp., Urbana
and Univ. of Illinois at Urbana-Champaign. (151.7)
4:15 Does the Left Hand Know What the Right Hand Is
Doing? Part Ii: Alignment between the AFRI Childhood
Obesity Prevention Challenge Area Program and the
2010 Dietary Guidelines. M.M. Koenings, C. Perez,
K. Krishnan, D.N. Chester. IFSN, NIFA, Washington,
DC and Texas A&M Univ., Bryan. (433.2)
4:30
Menstrual Cycle Hormones, Food Intake, and Cravings.
S. Krishnan, R. Tryon, L.C. Welch, W.F. Horn, N.L.
Keim. Univ. of California, Davis and USDA, Davis.
(418.6)
4:45
Network Social Support for Healthy and Obesogenic
Behavior Influences Children’s Dietary Intake and
Weight Change during Family-Based Behavioral
Obesity Treatment. K.N. Balantekin, J.F. Hayes, R.P.
Kolko, R.I. Stein, B.E. Saelens, R.R. Welch, M.G.
Perri, K.B. Schechtman, L.H. Epstein, D.E. Wilfley.
Washington Univ. Sch. of Med., Univ. of Pittsburgh,
Seattle Children’s Hosp., Univ. of Florida and Univ. at
Buffalo. (270.5)
47.
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
ASN EMERGING LEADERS IN NUTRITION
SCIENCE POSTER COMPETITION
Poster Award Competition
Finalists of the poster competition will be judged onsite.
Announcement of the winners will be at the RIS and Council meetings.
Please see the onsite Emerging Leaders in Nutrition Science Poster
Competition Program Book for announcement details.
Poster judging will occur between 5:00 and 6:00 pm and will
be a closed event. The event and reception will open to attendees
at 6:00 pm.
12
5:00
5:00
Effects of Polyphenolic-Rich Dark Chocolate and
Almonds on Cardiovascular Risk Factors in
Overweight and Obese Adults. Y. Lee, C. Berryman,
S. West, C-Y.O. Chen, J. Blumberg, A. Preston, K.
Lapsley, J. Fleming, P. Kris-Etherton. Penn State,
USDA at Tufts Univ., Hershey Co., PA and Almond Bd.
of California, Modesto. (293.1)
Effect of Vitamin D3 Supplementation on Telomerase
Activity in Hispanics with Type 2 Diabetes. G.G. Zarini,
M. McLean, J. Vaccaro, J. Exebio, S. Ajabshir, F.G.
Huffman. Florida Intl. Univ. (1156.1)
Blood Cholesterol in Late-Life and Cognitive Decline:
A Longitudinal Study of the Chinese Elderly. C.
Ma, Z. Yin, J. Luo, P. Zhu, X. Shi, X. Gao. Penn
State, Chinese Ctr. for Dis. Control and Prevent.,
Beijing. (407.4)
Gray Matter Thickness of Inferior Frontal Cortex Mediates
the Relationship between Phosphatidylcholine and
Executive Functions in Healthy, Older Adults. M.K.
Zamroziewicz, T. Das, S.L. Pereira, A.K. Barbey.
Univ. of Illinois Urbana-Champaign and Abbott Nutr.,
Columbus, OH. (407.7)
Dietary Protein and Functional Decline in Middle-Aged
and Older Adults in the Framingham Offspring Study.
J. Mustafa, M.R. Singer, M.L. Bradlee, R.C. Ellison,
L.L. Moore. Boston Univ. Sch. of Med. (1156.3)
Hypoxia Compromised Barrier Integrity in IPEC-J2
Monolayer Independent of Oxidative Stress. F. Liu,
J.M. Lyte, N.K. Gabler, F.R. Dunshea. Univ. of
Melbourne and Iowa State Univ. (1158.1)
The Modulatory Effect of Common Dietary Fatty Acids
on IPEC-J2 Transport of Lipopolysaccharide and
Monolayer Barrier Integrity In Vitro. J.M. Lyte, N.K.
Gabler, J.H. Hollis. Iowa State Univ. (1158.2)
Black Berry Polyphenol Reduce Nox1 Function to
Inhibit Senescence in Vascular Smooth Muscle Cells.
J. Huang, R. Feresin, Y. Zhao, S. Pourafshar, B.H.
Arjmandi, G. Salazar. Florida State Univ. and Univ. of
Arkansas for Med. Sci. (420.2)
Consuming < or > 0.5 Servings of Red Meat per Day
Does Not Have a Negative Impact on Cardiovascular
Disease Risk Factors: A Systematic Review and
Meta-analysis of Randomized Controlled Trials. L.E.
O’Connor, J. Kim, W.W. Campbell. Purdue Univ.
(904.1)
Adherence to a Mediterranean Diet, and Effects on
Cardiometabolic Health in Older Australian:; Results
from the MedIterranean Diet for Cognition and
Cardiovascular Health in the Elderly (MedLey) Trial.
C.R. Davis, J. Bryan, C. Wilson, J. Hodgson, R.
Woodman, K. Murphy. Univ. of South Australia, Sch.
of Med., Flinders Univ. and Univ. of Western Australia.
(293.5)
From Visceral Fat to Brain Function: The Selectively
Negative Influence of Central Adiposity on
Neuroelectric Indices in Preadolescent Children. L.
Raine, N. Cohen, A. Kramer, C. Hillman, N. Khan.
Univ. of Illinois Urbana Champaign. (679.1)
DHA Status Is Related to Prefrontal Cortex-Mediated
Impulse Control in Adolescents. V.L. Darcey, S. El
Damaty, E.J. Rose, D.H. Fishbein, J.W. VanMeter.
Georgetown Univ. and Penn State. (407.3)
SATURDAYNUTRITION
5:00
Fuzhuan Tea Reverses Western Diet-Induced Arterial
Stiffness in Mice. D. Lee, M. Battson, D. Jarrell, K.
Sevits, T. Weir, K. Cox-York, C. Gentile. Colorado
State Univ. (904.15)
5:00 Carbohydrates Differentially Influence Children’s
Efficiency during Cognitive Control Tasks. L. Raine,
N. Cohen, A. Kramer, C. Hillman, N. Khan. Univ. of
Illinois Urbana Champaign. (679.2)
5:00 Differential Relationship between Thigh and Calf
Intramuscular Adipose Tissue Depots and Indices
of Metabolic Health in Older Overweight and Obese
Adults. R.E. Bergia, J.E. Kim, W.W. Campbell.
Purdue Univ. (904.4)
5:00
The Fat Content of Milk Does Not Affect the Plasma
Glucose and Insulin Responses to a Meal. J. Li, E.
Janle, W.W. Campbell. Purdue Univ. (904.5)
5:00 Muscadine Grape (Vitis rotundifolia and Wine
Phytochemicals Mitigates Dextran Sulfate SodiumInduced Colitis in Mice. R. Li, A.K. Sandhu, C. Gao,
L. Gu. Univ of Florida and Illinois Inst. of Technol.
(1158.3)
5:00
Coconut Oil Supplementation: An Innovative Strategy
for Cardiovascular Disease Risk Reduction. C.
Thompson-Felty, C.S. Johnston, A. Ryder. Arizona
5:00
Incorporation of Almonds in a Cholesterol-Lowering Diet
Improves Non-ABCA1-Mediated Cholesterol Efflux in
Normal Weight Adults. C.E. Berryman, J.A. Fleming,
P.M. Kris-Etherton. Penn State. (293.2)
5:00
Choline and Its Metabolites Are Differentially Associated
with Cardiometabolic Risk and Cardio- and Cerebrovascular Disease. A.J. Roe, A.H. Lichtenstein, I.H.
Rosenberg, E.J. Johnson, T.M. Scott. Univ. of Idaho
and USDA at Tufts Univ. (904.18)
5:00
Choline Supplementation Improves Behavioral Aspects
of Mice Exposed to Ethanol In Utero. E. Pjetri, N.
Surzenko, C.A. Munson, S.H. Zeisel. Univ. of North
Carolina at Chapel Hill, Kannapolis. (679.3)
5:00 EGCG Decreases Mortality in a Dose-Dependent
Fashion but Does Not Improve Cognition in Aged
Mice. B.D. Pence, T.K. Bhattacharya, J.L. Rytych,
P. Park, J.M. Allen, Y. Sun, R.H. McCusker, K.W.
Kelley, R.W. Johnson, J.S. Rhodes, J.A. Woods.
Univ. of Illinois Urbana-Champaign. (407.1)
5:00 Relation of Total Sugars and Fructose-Containing
Sugars with Risk of Cardiovascular Disease: A
Systematic Review and Meta-analysis of Prospective
Cohort Studies. T.A. Khan, S. Blanco-Mejia, R.
de Souza, C.W.C. Kendall, J.L. Sievenpiper. St.
Michael’s Hosp., Toronto, Univ. of Toronto, McMaster
Univ., Hamilton, ON and Univ. of Saskatchewan,
Canada. (904.7)
5:00
Metabolism of Uniformly Labelled 13C-Eicosapentaenoic
Acid and 13C-Arachidonic Acid during Healthy Aging.
P. Léveillé, R. Chouinard-Watkins, S. Cunnane,
J.T. Brenna, M. Plourde. Univ. of Sherbrooke, Res.
Ctr. on Aging, Sherbrooke, Laval Univ., Canada and
Cornell Univ. (1156.5)
5:00
Gene Expression of Vitamin D Regulatory Enzymes
in Renal Tissue of Growing Pigs Is Modulated by
Maternal Dietary Vitamin D Concentrations. L.
Amundson, T. Crenshaw. Univ. of WisconsinMadison. (287.2)
5:00
Consequences of Maternal Iron-Deficiency: Fetal
Anemia, and Hypoxia in Select Tissues of the
Conceptus. A. Woodman, Y. Mansour, S. Bourque.
Univ. of Alberta. (287.3)
5:00 Prebiotics and β-Glucan Affect Jejunal and Serum
Alkaline Phosphatase Affinity in Weanling Pigs.
M-A.N. Hayhoe, T. Archbold, M.Z. Fan. Univ. of
Guelph, Canada. (915.38)
5:00
Alpha-Melanocyte Stimulating Hormone Affects Adipose
Tissue Physiology in Broiler Chicks. S.L. Shipp, G.
Wang, X. Fu, M. Cline, E. Gilbert. VPI and State
Univ. (915.25)
5:00 Multiple Vitamins, Not Glutamine-Supplemented
Resuscitation Fluid Improves Intestinal Integrity and
Alters Systemic Inflammatory Mediators in Rats with
Trauma-Hemorrhagic Shock. Y.H. Lin, H-C. Lo, T-C.
Su. Fu Jen Catholic Univ. and Changhua Christian
Hosp., Taiwan. (915.32)
5:00
Effects of Choline Deficiency on Composition of Sow’s
Milk. A.T. Mudd, S.K. Johnson, L.S. Alexander, C.M.
Getty, R.N. Dilger. Univ. of Illinois, Urbana. (915.7)
5:00 Maternal Consumption of a Diet Lacking Omega-3
Fatty Acids during Development Alters Pup Behavior
and Brain Metabolism Later in Life. C. Jackson, M.
Alhado, E. Gonzales, J. Shumake, D. Barrett, F.
Gonzalez-Lima, M.A. Lane. Texas State Univ. and
Univ. of Texas at Austin. (915.3)
5:00 Enriching the Maternal Diet in Long Chain n-3
Polyunsaturated Fatty Acids Alters Lipid Metabolites
and Adiposity in Broiler Chicks. R. Beckford, S.
Howard, S. Das, A. Tester, S. Campagna, J. Whelan,
J. Wilson, B. Voy. Univ. of Tennessee, Knoxville and
Univ. of Georgia. (124.1)
5:00
Time-Restricted Feeding of a High-Fat Diet Reduces
Adiposity and Inflammatory Cytokine Production in
Mice. S. Sundaram, L. Yan. USDA, Grand Forks.
(915.31)
5:00
Activation of Ubiquitin-Proteasome System Components
in Heat-Stressed Pig Skeletal Muscle. L.D. Zhao, Z.
Zhang, G. Xie, J.T. Selsby, L.H. Baumgard, R.P.
Rhoads. Virginia Tech and Iowa State Univ. (915.34)
5:00 Metabolic Phenotype and Increased Adiposity in
a Mouse Model of Chronic Gestational Alcohol
Exposure. R.M. Amos-Kroohs, D.W. Nelson, C-L.E.
Yen, S.M. Smith. Univ. of Wisconsin-Madison. (287.5)
5:00 Food Insecurity Is Associated with Faster Cognitive
Decline: Boston Puerto Rican Health Study. J. Wong,
T. Scott, P. Wilde, Y. Li, K.L. Tucker, X. Gao. Brigham
and Women’s Hosp., Tufts Med. Ctr., Friedman Sch.
of Nutr. Sci. and Policy, Tufts Univ., Univ. of South
Florida, Univ. of Massachusetts Lowell and Penn
State. (273.3)
5:00
HomeStyles: Recruitment Strategies for a Childhood
Obesity Prevention Randomized Controlled Trial. J.T.
Martin-Biggers, C. Delaney, M. Koenings, C. ByrdBredbenner. Rutgers Univ. (422.2)
5:00
Food Label Use Improves Dietary Quality and Mediates
Improved Glycemic Control in Latinos with Type
2 Diabetes: The DIALBEST Trial. G. Kollannoor
Samuel, F.M. Shebl, S. Segura-Pérez, J. Chhabra,
S. Vega-López, R. Pérez-Escamilla. Yale Sch. of
Publ. Hlth., Hispanic Hlth. Council, Harford, CT,
Hartford Hosp. and Arizona State Univ. (422.5)
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Cross-Country Comparison of the Acceptability of
a Social Support Behavior Change Strategy to
Improve Adherence to Antenatal Calcium and
Iron-Folic Acid Supplementation. S. Martin, M.
Omotayo, G. Chapleau, R. Stoltzfus, Z. Birhanu, S.
Ortolano, K. Dickin. Cornell Univ. and Jimma Univ.,
Ethiopia. (422.7)
The Impact of Nutrition Label Usage on Food Selection
and Consumption in a University Dining Setting. M.J.
Christoph, B.D. Ellison. Univ. of Illinois at UrbanaChampaign. (422.8)
Women’s Empowerment and Food Security Status: A
Global Comparative Study of Women Living in Rural
and Urban Areas. K. Sinclair, D. Ahmadigheidari, D.
Dallmann, H. Melgar-Quiñonez. McGill Univ., Ste.
Anne de Bellevue, QC. (149.2)
Marginal Food Insecurity Is Associated with Increased
Sodium and Decreased Fruit Consumption in
Mothers and Toddlers from Low-Income Households.
M. Spiker, K. Hurley, Y. Wang, R. Arbaiza, M. Black.
Johns Hopkins Bloomberg Sch. of Publ. Hlth. and
Univ. of Maryland Sch. of Med. (149.4)
Strong Interpersonal Relationships Buffer the Impact of
Chaos on Quality of Family Meal Interactions in FoodInsecure Households. T.N. Rosemond, C. Blake, J.
Bernal, M.P. Burke, E.A. Frongillo. Univ. of South
Carolina, Univ. Simon Bolivar, Venezuela and USDA,
Alexandria, VA. (149.6)
Ethnic Differences in Cumulative Exposure to Food
Insecurity and Risk of Childhood Asthma. L.D.
Mangini, Y. Dong, M.D. Hayward, M.R. Forman. The
Univ. of Texas at Austin. (273.1)
Household Food Insecurity Access Scale and Household
Food Insecurity Access Prevalence as Predictor
of Stunted Child and Overweight/Obese Mother in
Urban Indonesia. T. Mahmudiono, D.R. Andrias, T.S.
Nindya, H. Megatsari, R. Rosenkranz. Kansas State
Univ. and Univ. Airlangga, Indonesia. (273.8)
The Relationship between Weight Loss Advice from
Friends on Self-Perception of Weight and Eating
Habits. T. Thibodeau, I. van Woerden, P. OhriVachaspati, J. Huberty, M. Bruening. Arizona State
Univ. (408.2)
Promotion of Drinking Water among Latino Immigrant
Youth. N. Barrett, U. Colón-Ramos, I. Rivera, W.D.
Evans, M. Edberg. George Washington Univ. Milken
Inst. Sch. of Publ. Hlth. and Rivera Group Inc.,
Washington, DC. (408.3)
Nutrient Intake among Overweight/Obese Hispanic
Women Based on Type 2 Diabetes Diagnosis Status.
M. Arias-Gastelum, N.M. Lindberg, A.G. Rosales,
M. Petrovic, E.S. LeBlanc, V.J. Stevens, T.J. Kapka,
R.T. Meenan, S. Vega-López. Arizona State Univ.,
Kaiser Permanente Ctr. for Hlth. Res., Portland and
Virginia Garcia Mem. Hlth. Ctr., Hillsboro, OR. (408.4)
Associations between Dysfunctional Eating Behaviors
and Cardiovascular Risk among Latinos. A.A. LopezCepero, C.M. Frisard, S.C. Lemon, M.C. Rosal.
Univ. of Massachusetts Med. Sch. (408.6)
Availability and Price of Fruits and Vegetables at Food
Retailers in Western Massachusetts Counties. Q.
Jiang, J. Burdick, J. Chaiken, S. Walsh, N. Cohen.
Univ. of Massachusetts Amherst. (129.3)
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
The Usual Nutrient Intakes of U.S. Children and
Adolescents by Milk Drinking Behavior. Y. Zhao, R.
Bailey, C. Weaver, G. McCabe, H. Eicher-Miller
Purdue Univ. (899.2)
Food Security: Motivations to Volunteer in Food Rescue
Nutrition. T.Y. Mousa, J.H. Freeland-Graves. Univ. of
Texas at Austin. (899.5)
Usual Dietary Intake among Children 2-5 Years in a
Community at High Risk for Obesity: Comparison
to Age-Matched NHANES Data, 2009-2012. B.R.
Markides, S.H. Crixell, L. Biediger-Friedman. Texas
Acculturation, Diet and Psychological Health of Asian
International Students at the University of Delaware.
H. Jiang. Purdue Univ. (901.25)
Comparing the Food Environment of Native American
Tribal Areas to That of Non-tribal Areas in California.
Y. Shen, D. Antiporta, S. Kodish, V.M. Oddo,
G. Chodur, J.C. Jones-Smith. Johns Hopkins
Bloomberg Sch. of Publ. Hlth. (1151.2)
Impact of Folic-Acid Intervention and MTHFRC677T
Gene Polymorphism on All-Cause Mortality
Associated with Elevated Serum Homocysteine
Levels in Chinese Adults with Hypertension. B. Xu,
X. Kong, R. Xu, M. Zhao, Y. Song, C. Zhang, T. Yu, L.
Liu, F. Fan, Y. Zhang, X. Qin, G. Tang, B. Wang, F.F.
Hou, Y. Huo, J. Li. River Hill High Sch., Clarksville,
MD, Peking Univ. First Hosp., Beijing, Nanfang Hosp.,
Southern Med. Univ., Guangzhou and Anhui Med.
Univ., China. (422.3)
Longitudinal Quality of Life Improvement after a FamilyBased Lifestyle Intervention in Youth with Obesity.
S.R. Engebretsen, K. Briggs Early, R. Sorrells, J.P.
Yi-Frazier, M. Sanchez, K. Gottlieb, B.L. Gonzalez,
B. Lopez. Pacific Northwest Univ. of Hlth. Sci., Seattle
Children’s Res. Inst. and Yakima Valley Mem. Hosp.,
WA. (422.4)
Understanding Acceptance, Compliance, and Utilization
of Micronutrient Powder in Northern Nigeria –
Informing
Implementation
through
Formative
Research. S.R. Kodish, C.L. Ejembi, T. Osunkentan,
A. Imohe, P. Mathema. Johns Hopkins Bloomberg
Sch. of Publ. Hlth., Ahmadu Bello Univ., Nigeria and
UNICEF Nigeria. (422.6)
Differential Associations of Food Insecurity Risk on
Dietary Intake-Frequency among Parents and Their
Adolescent Children. E. Calloway, T. Smith, C.
Pinard, A. Oh, L. Nebeling, E. Hennessy, A. Yaroch.
Gretchen Swanson Ctr. for Nutr., Omaha and NCI,
NIH. (149.1)
High Household Food Insecurity Impacts Dietary
Patterns in Rural and Urban American Indian Families
with Young Children. E. Tomayko, K. Mosso, K.
Cronin, R. Prince, A. Adams. Univ. of WisconsinMadison. (149.8)
Are Monthly Food Insecurity Assessments Necessary?
A Longitudinal Analysis in Rural Zambia. M. Na,
B.L. Caswell, S.A. Talegawkar, A. Palmer. Johns
Hopkins Bloomberg Sch. of Publ. Hlth. and George
Washington Univ. (273.6)
SATURDAYNUTRITION
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5:00
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5:00
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5:00
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A More Efficient Method of Assessing Corner Store
Healthfulness. R. DeWeese, M. Todd, A. Karpyn,
M. Yedidia, M. Kennedy, M. Bruening, C. Wharton,
P. Ohri-Vachaspati. Arizona State Univ., Univ. of
Delaware and Rutgers Univ. (129.5)
What Do Parents and Children Talk about While
Grocery Shopping? A Content Analysis of Shopping
Trips. E. Calloway, A. Pritchard, C. Roberts-Gray, S.
Sweitzer, M. Briley. Gretchen Swanson Ctr. for Nutr.,
Omaha, Univ. of Texas at Austin and Third Coast
Res., Galveston. (129.6)
E-Mechanic Exercise Interventions Eliminate the
Unexpected Association between Weight Gain and a
Healthy Food Environment. C.A. Myers, S.T. Broyles,
T.S. Church, C.K. Martin. Pennington Biomed. Res.
Ctr., Baton Rouge. (1151.7)
Perceived Benefits of Livestock Ownership among
Female Smallholder Farmers of Mixed HIV Status in
Nyanza Province, Kenya. A. Maranga, S.E. Dumas`,
P.E. Mbullo, P. Wekesa, M. Onono, S.L. Young.
Cornell Univ. and Kenya Med. Res. Inst. (KEMRI),
Nairobi. (273.2)
Food Insecurity Is Associated with Depression and Stress
among a Cohort of Pregnant Kenyan Women of Mixed
HIV Status. I. Tsai, N.R. Krumdieck, S. Collins, E.M.
Widen, P. Wekesa, M. Onono, S.L. Young. Cornell
Univ., Weill Cornell Med., Columbia Univ. Med. Ctr.
and Kenya Med. Res. Inst., Kisumu. (273.4)
It’s Not How Much Your Spend, It’s Where You Spend
It: How Consumer Behavior Predicts Dietary Energy
Density. A. Massedge, J.A. Vernarelli. Fairfield Univ.
(129.4)
High Overweight/Obesity Risk among Children Enrolled
in Michigan Migrant and Seasonal Head Start
Programs, 2012. C. Nance-Panek, S. Song, Y.M.
Lim, E.T. Crockett, W.O. Song. Michigan State Univ.
(901.9)
Physical Activity and Inactivity and Its Association with
Overweight and Obesity on Children and Adolescents
between 10 to 14 Years Old. I.Y. Pantoja, X.
Sandoval, J.O. Talavera, M. Pérez. UNAM, Univ.
Iberoamericana and Mexican Soc. Security Inst.,
Mexico City. (1151.9)
Cranberry Extract Initiates Intrinsic Apoptosis in HL-60
Cells by Increasing Bad Activity through the Inhibition
of Akt Phosphorylation. R. Mansouri, S.S. Percival.
Univ. of Florida. (147.8)
Effect of 1,25(OH)2D in Regulating Glutamic-Oxaloacetic
Transaminase 1 and Redox Balance during Breast
Cancer Progression. X. Zhou, T. Wilmanski, D.
Teegarden. Purdue Univ. (42.5)
Microenvironment Folate Stress Promotes WarburgMetabolic Switched-Cancer Stem Cell Signaling
Network and Stemness Features to Mediate Invasion
and Metastasis of Lung Cancers. W-J. Chen, R-F.S.
Huang. Fu-Jen Catholic Univ., Taiwan. (147.7)
Inactivation of Pyruvate Dehydrogenase Complex
Mediates the Selective Effects of Butyrate on
Colorectal Cancer Cells. A. Han, N. Bennett,
A. MacDonald, M. Johnstone, J. Whelan, D.R.
Donohoe. Univ. of Tennessee, Knoxville. (42.8)
5:00
Dried Plums Modify Fecal Short Chain Fatty Acid
Concentrations and Gene Expression in a Rat Model
of Colon Carcinogenesis. D.V. Seidel, K.K. Hicks,
S.S. Taddeo, M.A. Azcarate-Peril, R.J. Carroll, N.D.
Turner. Texas A&M Univ. and Univ. of North Carolina
at Chapel Hill. (147.3)
5:00 Apiaceous and Cruciferous Vegetables Fed in the
Post-initiation Stage Reduce Colonic Precancerous
Lesions and the Cancer Stem Cell Marker
DCLK1, and Alter the miRNA Expression Profile in
1,2-Dimethylhydrazine-Treated Rats. S. Kim, S.P.
Trudo, D.D. Gallaher. Univ. of Minnesota, St. Paul
and Univ. of Arkansas Sch. of Human Envrn. Sci.
(147.4)
5:00
Dietary Tomato Reduces Castration-Resistant Prostate
Cancer Burden in the TRAMP Model. J.W. Smith, J.L.
Rowles III, R.J. Miller, S.K. Clinton, W.D. O’Brien;
Jr., J.W. Erdman; Jr. Univ. of Illinois at UrbanaChampaign and The Ohio State Univ. (147.1)
5:00
The Effect of Oil Palm Phenolics on Pancreatic Ductal
Adenocarcinoma in Transgenic Mouse Model. N.H.
Razalli, P. Gowthaman, N. Saadat, S. Vemuri, A.
Goja, R. Sambanthamurthi, S.V. Gupta. Wayne
State Univ. and Malaysian Palm Oil Bd., Kajang.
(147.2)
5:00
Consumption of Total and Individual Sugars, Sugary
Foods and Sugary Beverages in Relation to
Adiposity-Related Cancer Risk in the Framingham
Offspring Cohort (1991-2013). N. Makarem, Y. Lin,
E.V. Bandera, P. Jacques, N. Parekh. NYU, Rutgers
Univ. and USDA at Tufts Univ. (42.1)
5:00 Effect of Short-Chain Fatty Acid Acetate on Colon
Cancer. M. Sahuri Arisoylu, J.D. Bell. Univ. of
Westminster, U.K. (42.7)
5:00
Excess Dietary Iron Modulates Intestinal Tumorigenesis.
L. Glosser, J. Swain. Case Western Reserve Univ.
(1167.9)
5:00 Dietary Supplementation with Tart Cherries for
Prevention of Inflammation-Associated Colorectal
Cancer in Mice. A. Hunter, D. Larson, S. Phatak, K.
Hintze, A. Benninghoff. Utah State Univ. (1167.12)
5:00 Protective Effect of Betaine against Liver Steatosis
Involves Depletion of Homocysteine via Upregulation
of Betaine-Homocysteine Methyltransferase. C.W.
Ahn, D.S. Jun, J.D. Na, Y.J. Choi, Y.C. Kim. Seoul
Natl. Univ. (691.19)
5:00
Genetic Background Determines Anthocyanin Effects
on Glutathione Redox Balance. K.M. Norris, R.
Pazdro. Univ. of Georgia. (691.27)
5:00 Unfermented and Fermented Cocoa Extracts as
Inhibitors of Pancreatic α-Amylase, α-Glucosidase,
and Pancreatic Lipase. C. Ryan, L. Ye, S. O’Keefe,
A.P. Neilson. Virginia Tech. (691.30)
5:00
The Effects of Dietary Cocoa Powder on Inflammatory
Markers and Catalase Activity in Participants with
Type 2 Diabetes following a Fast Food Style Meal
Challenge. M. Foster, N. Betts, D. Fu, T. Lyons, A.
Basu. Oklahoma State Univ. and Queen’s Univ. of
Belfast. (1174.14)
5:00
Dried Plum Consumption Improves Antioxidant Capacity
and Reduces Inflammation in Postmenopausal
Women. M. Nakamichi-Lee, S. Hooshmand, M.
Kern, A. Ahouraei, M.Y. Hong. Sch. of Exer. & Nutr.
Sci., San Diego State Univ. (1174.19)
15
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Lycopene Inhibits Amyloid-β25-35-Induced Apoptosis by
Decreasing Intracellular and Mitochondrial Ros Levels
in Human Neuronal SH-SY5Y Cells. S. Hwang, J.W.
Lim, H. Kim. Col. of Human Ecol., Yonsei Univ., South
Korea. (404.5)
The Heat Shock Protein 70 Is a Novel Target for
Nobiletin in Human Colon Cancer Cells. Z. Gao, J.
Zheng, X. Wu, K. Dimova, S. Scordilis, H. Xiao. Univ.
of Massachusetts Amherst and Smith Col. (691.2)
Modulation of Cerebral Activity Induced by α-Casozepine,
a Benzodiazepine-Like Peptide Derived from Bovine
Casein. S. Benoit, C. Chaumontet, Cakir-Kiefer, D.
Tomé, L. Miclo. AgroParisTech, INRA, Univ. ParisSaclay and Univ. de Lorraine-Nancy, France. (125.4)
Long-Term Feeding of a Soy-Protein-Based Diet
Improves Trabecular and Cortical Bone Outcomes
in Low-Fit, Intact and Ovariectomized Female Rats.
M.W. Richard, L.C. Ortinau, T.M. Zidon, P.S. Hinton,
V. Vieira-Potter. Univ. of Missouri-Columbia. (125.3)
Collagen Peptides Derived from Alaska Pollock Skin
Protect against TNFα-Induced Dysfunction of Tight
Junctions in Caco-2 Cells. Q. Chen, B. Li, I. Martin,
J.B. Blumberg, C-Y.O. Chen. Ocean Univ. of China,
USDA at Tufts Univ. and State Univ. of Campinas,
Brazil. (125.5)
Cocoa Increases Postprandial GLP-1 Response in
Adults with Impaired Glucose Tolerance. K. Strat,
B.M. Davy, M.W. Hulver, K.P. Davy, A.P. Neilson.
Virginia Tech. (428.5)
Green Tea Extract Lowers NFκB-Mediated Inflammation
during Nonalcoholic Steatohepatitis in Mice Fed a HighFat Diet Consistent with Reduced Toll-Like Receptor-4
Signaling. J. Li, C. Chitchumroonchokchai, J.B.
Kim, M.V. Moller, R.S. Bruno. The Ohio State
Univ. (269.2)
Anti-inflammatory and Anti-cancer Effects of the Colonic
Metabolites of Polymethoxyflavone. M. Wang, X. Wu,
M. Song, H. Xiao. Univ. of Massachusetts Amherst.
(269.1)
The Impact of Limonin on Gut Microbiota. M. Gu, J. Sun,
C. Qi, K.X. Cai, T. Goulette, Y.M. Song, M.X. You, D.
Sela, H. Xiao. Univ. of Massachusetts Amherst and
Jiangnan Univ., China. (416.5)
Effect of Frequent Broccoli Intake on Rat Gut Microbiota
Metabolism and Composition. Y. Wang, X. Liu, M.J.
Miller, E.H. Jeffery. Univ. of Illinois, Urbana. (690.13)
Efficacy of Chewing Gum as a Delivery System for
Water and Fat Soluble Vitamins. W.Y.H. Khoo, J.D.
Lambert. Penn State. (690.18)
Acute Bioavailability of (Poly)phenolic Content of
Different Varieties of Vaccinium spp. in Ovariectomized
Rats. M. Maiz, D.P. Cladis, P.J. Lachcik, E.M. Janle,
M.A. Lila, M.G. Ferruzzi, C.M. Weaver. Purdue Univ.
and North Carolina State Univ., Kannapolis. (690.20)
Delta and Gamma Tocotrienol Attenuate NLRP3
Inflammasome Activation in J774 Macrophages via
NFκB-Dependent Priming Inhibition. T. Buckner, Y.
Kim, S. Chung, M. Engel. Univ. of Nebraska-Lincoln.
(1174.6)
5:00
Validating Polyphenol Intake Estimates from a FoodFrequency Questionnaire Using Repeated 24-Hour
Dietary Recalls and a Unique Method of Triads
Approach with Two Biomarkers. N. BurkholderCooley, S. Rajaram, E. Haddad, G.E. Fraser, K. Oda,
K. Jaceldo-Siegl. Loma Linda Univ. (690.6)
5:00
Intake of 2 Eggs for Breakfast Increases Plasma Lutein
Concentration in Association with Increased Large
HDL and Zeta Potential as Compared to an Oatmeal
Breakfast. A.C. Missimer, S. Hu, Y. Luo, C.N. Blesso,
M-L. Fernandez. Univ. of Connecticut. (690.7)
5:00
Korean Red Ginseng Extract Inhibits p53-Dependent
Apoptosis In Helicobacter pylori- Infected Gastric
Epithelial Cells. HJ. Kang, J.W. Lim, H. Kim. Col. of
Human Ecol., Yonsei Univ., South Korea. (691.24)
5:00 Cyanidin, a Natural Anti-glycation Agent, Inhibits
Methylglyoxal- and Glucose-Mediated Protein
Glycation In Vitro. T. Suantawee, H. Cheng, S.
Adisakwattana. Chulalongkorn Univ., Thailand and
LSU Sch. of Vet. Med. (692.9)
5:00
Xylobiose Ameliorates Hyperglycemia and Dyslipidemia
via Regulating Hepatic Lipogenic Genes in db/db
Mice. E. Kim, E. Lim, S. Jung, S-H. Yoo, Y. Kim.
Ewha Womans Univ., TS Corp., Inchon and Sejong
Univ., South Korea. (692.10)
5:00
The Effect of Oil Palm Phenolics on Urinary Metabolomic
Profile In Atherogenic Diet-Induced Rat Model of
Alzheimer’s Disease. Y. Wu, V. Srirajavatsavai, R.
Sambanthamurthi, S.V. Gupta. Wayne State Univ.
and Malaysian Palm Oil Board, Kuala Lumpur.
(692.21)
5:00 Neurorescue Effect of EGCG in an Animal Model
of Parkinson’s Disease. Q. Xu, M. Langley, A.
Kanthasamy, M. Reddy. Iowa State Univ. (1174.11)
5:00 Anti-proliferative
and
Anti-inflammatory
Action
of Blueberry Polyphenols in HIG-82 Rabbit
Synoviocytes. S. South, J. Lucero, V. Imrhan, C.
Prasad, P. Vijayagopal, S. Juma. Texas Woman’s
Univ. (1174.20)
5:00 Blueberry Supplementation Alters Biomarkers of
Oxidative Stress in High-Fat Fed Rats. K.I. Keirsey,
S. Lee, C.B. de La Serre, J.G. Fischer. Univ. of
Georgia. (1174.23)
5:00 Tannase-Treated Grape Pomace Attenuates IL-1βInduced Inflammation in Caco-2 Cells. I. Martin, G.
Macedo, J. Blumberg, C-Y.O. Chen. USDA at Tufts
Univ. and State Univ. of Campinas (UNICAMP),
Brazil. (269.4)
5:00
Gamma Tocotrienol Suppresses NLRP3 Inflammasome
by Dual Mechanism of A20-Mediated Priming
Inhibition and AMPK/Autophagy Axis Activation. Y.
Kim, S. Chung. Univ. of Nebraska-Lincoln. (269.5)
5:00
Protective Effect of Pteropyrum scoparium and Oxalis
Corniculata against Streptozotocin- Induced Diabetes
in Rats. I.R.S. Al-Qalhati, M. Waly, Z. Al-Attabi, L.K.
Al-Subhi. Sultan Qaboos Univ., Oman. (1176.4)
5:00
Avenanthramides 2c, 2f and 2p Regulate Osteoblast
Gene Expression and Survival In Vitro. G.G.
Pellegrini, C.C. Morales, J. Johnson, T.C. Wallace,
T. Bellido. Indiana Univ. Sch. of Med., PepsiCo Inc.,
Barrington, IL and Natl. Osteoporosis Fndn., Arlington,
VA. (1174.9)
SATURDAYNUTRITION
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
Effects of Acute n-3 Fatty Acid Administration on
Cardiac Lipid Metabolism and Ca2+ Homeostasis
during Ischemia-Reperfusion. H. Zirpoli, N. Quadri,
K.M. O’Shea, R. Ananthakrishan, M. Abdillahi, R.
Rosario, R.J. Deckelbaum, R. Ramasamy. Col.
of P&S, Columbia Univ. Med. Ctr. and NYU Med.
Ctr. (404.2)
Dietary Small RNA Modulation of Gut Microbiota
Composition: In Silico and In Vitro Analyses. H.
Huang, C. Davis, L. Yu, T.T.Y. Wang. USDA, Beltsville,
MD, ODS, NIH and Univ. of Maryland College Park.
(416.1)
Probiotic Lacidofil® STRONG Mitigates the AntibioticInduced Alteration of the Fecal MicroRNA Signature in
Healthy Humans. A. Taibi, E.M. Comelli, S-A. Girard,
T.A. Tompkins. Univ. of Toronto, Ctr. for Child Nutr.
and Hlth., Toronto and Lallemand Hlth. Solutions,
Monreal. (289.7)
Effects of Almonds on Cardiovascular Risk Factors in
Overweight and Obese Koreans. H. Jung, C-Y.O.
Chen, J.B. Blumberg, H-K. Kwak. Korea Natl. Open
Univ., Seoul and Tufts Univ., Boston. (1175.5)
Beneficial Cardiovascular Effects of Muscadine Grape
Extract in Normotensive Female Rats. A.V. Duncan,
H.A. Shaltout, E.N. Tommasi, P.E. Gallagher, E.A.
Tallant, D.I. Diz. Wake Forest Sch. of Med. (1175.7)
Nutritional Polyphenol Metabolites’ Kinetics in Plasma,
Urine, and Saliva following Consumption by Normal,
Healthy, Subjects. Y.Y. Choy, S.N. Hester, A.
Mastaloudis, S.M. Wood, R. Gray, R.P. O’Donnell,
J.L. Barger, P. Quifer-Rada, R.M. LamuelaRaventós, A.L. Waterhouse. Univ. of California,
Davis, Nu Skin Enterprises, Provo, UT, LifeGen
Technols., Madison, WI, Univ. of Barcelona and Inst.
of Hlth. Carlos III, Madrid. (690.2)
Soy Proteins Deficient in the α’ Subunit of β-Conglycinin
and Various Glycinin Subunits Maintain the Ability
to Modulate Hepatic Lipid and Glucose Metabolism.
C. Chatterjee, J. Liu, C. Wood, C. Gagnon, E.R.
Cober, J.A. Fregeau-Reid, S. Gleddie, C. Xiao. Hlth.
Canada, Agr. & Agri-Food Canada and Carleton Univ.,
Ottawa. (1175.2)
Green Tea Extract and Catechol-O-Methyltransferase
(COMT) Genotype Modify Fasting Serum Insulin and
Plasma Adiponectin Concentrations in a Randomized
Controlled Trial of Overweight and Obese
Postmenopausal Women. A. Dostal, H. Samavat,
L. Espejo, A. Arikawa, N.R. Stendell-Hollis, M.S.
Kurzer. Univ. of Minnesota, St. Paul, Univ. of North
Florida and Central Washington Univ. (289.1)
Effect of 3 Probiotic Strains on Bile Acids and Glucose
Metabolism in Healthy Adults: A Randomized,
Double-Blind Placebo-Controlled Crossover Study.
T. Culpepper, C.C. Rowe, C. Nieves, S-A. Girard,
M. Christman, S. Chung, T.A. Thompkins, B.
Langkamp-Henken. Univ. of Florida, Lallemand
Hlth. Solutions, Montreal, MCC Stat. Consulting LLC,
Gainesville and Univ. of Nebraska-Lincoln. (289.6)
Inhibition of High Glucose-Induced Diabetic Retinal
Angiogenesis by Dietary Compound Chrysin. M.
Kang,Y-H. Kang. Hallym Univ., South Korea. (691.16)
5:00 Obesity-Breast Cancer Interactions: Effects of
Adipocytes on Breast Cancer Cells and Preventive
Effects of Omega 3 Fatty Acids. S.A. Alhaj, A.
Aljawadi, L. Ramalingam, N. Moustaid-Moussa.
Texas Tech Univ. (691.29)
5:00
Ellagic Acid and Quercetin Are High-Affinity Ligands of
Human Peroxisome Proliferator-Activated Receptor
Alpha in an In Vitro Competitive Binding Assay. G.
Sasaki, T. Luo, N.F. Shay. Oregon State Univ. (691.7)
5:00 Inulin Effect on Weight Loss and Associated
Parameters with the Development of Cardiovascular
Disease in Obese Adults. F.H. Castro-Sanchez,
D.A. Ochoa-Acosta, N.G. Valenzuela-Rubio, M.
Dominguez-Rodriguez, J.A. Fierros-Valdez, M.
Vergara-JimenezSch. of Nutr. and Gastron.,
Autonomous Univ. of Sinaloa, Mexico. (1176.22)
5:00
The Effect of Fructose-Containing Sugars on Glycemic
Control: A Systematic Review and Meta-analysis
of Controlled Trials. V.L. Choo, A.I. Cozma, E.
Viguiliouk, S. Blanco Mejia, C.W.C. Kendall, R.J.
de Souza, D.J.A. Jenkins, J.L. Sievenpiper. Univ. of
Toronto, St. Michael’s Hosp., Toronto and McMaster
Univ., Canada. (685.5)
5:00 Higher Protein Intake Improves Sleep and Blood
Pressure, and Influences the Relation between
Changes in Blood Pressure and Sleep during Energy
Restriction in Middle-Aged Overweight and Obese
Adults. J. Zhou, J.E. Kim, W.W. Campbell. Purdue
Univ. (415.6)
5:00 Protection against Insulin Resistance in Obesity Is
Accompanied by Low Rates of Systemic Fatty Acid
Mobilization and Attenuated Markers of Fibrosis and
Inflammation in Adipose Tissue. D.W. Van Pelt, A.Y.
Wang, J.F. Horowitz. Univ. of Michigan. (291.1)
5:00
Lipid Emulsions, Rich in n-3 or n-9 Fatty Acids, Reverse
the Progression of Parenteral Nutrition-Induced
Hepatic Steatosis in Mice. K-H. Huang, P.B. Smith,
A.D. Patterson, A.C. Ross. Penn State. (267.2)
5:00 Intake of Genistein and Daidzein Ameliorates
Adiposity and Metabolic Syndrome in High Fat Fed
C57BL/6JMice. T. Luo, O. Miranda, A. Adamson,
N.F. Shay. Oregon State Univ. (291.5)
5:00
Dietary Linoleic Acid Increases Linoleic- and Arachidonic
Acid-Derived Bioactive Lipids, Despite Not Altering
Tissue Fatty Acid Levels. S.M. Leng, H.M. Aukema.
Univ. of Manitoba and CCARM, Winnipeg. (130.7)
5:00
The Effect of Dietary Protein on Bone during Weight
Loss: A Meta-Analysis and Systematic Review. C.S.
Wright, J. Li, W.W. Campbell. Purdue Univ. (415.4)
5:00
Effects of Dietary Protein and Fiber at Breakfast on
Postprandial Appetite, Neural Responses to Visual
Food Stimuli, and Ad Libitum Energy Intake at Lunch
in Overweight Adults. R.D. Sayer, A. Amankwaah,
G. Tamer; Jr, N. Chen, A. Wright, J. Tregellas, M.
Cornier, D. Kareken, T. Talavage, M. McCrory, W.
Campbell. Weldon Sch. of Biomed. Engin., Purdue
Univ., Univ. of Colorado Sch. of Med., Anschutz Med.
Campus, Indiana Univ. Sch. of Med. and Georgia
State Univ. (418.7)
17
S
A
T
NUTRITIONSATURDAY
5:00
DHA Is More Potent Than EPA in Attenuating
Cardiometabolic Risk in Men and Women: A
Randomized
Double-Blind,
Placebo-Controlled
Crossover Trial. J. Allaire, P. Couture, A. Charest,
M. Leclerc, J. Marin, M-C. Lépine, A. Tchernof, B.
Lamarche. Univ. Laval and Univ. Inst. of Cardiol. and
Pneumol. of Québec. (130.1)
5:00
Effects of Hormone Therapy on the Association between
Erythrocyte Levels of n-3 Polyunsaturated Fatty Acids
and Depression in Postmenopausal Women. Y. Jin, Y.
Park. Hanyang Univ., South Korea. (267.3)
5:00 Adipocyte-Specific Ablation of Long-Chain Acyl-CoA
Synthetase-4 in Mice Protects against Diet-Induced
Obesity-Associated Decreases in White Adipocyte
Oxygen Consumption and Whole Body Energy
Expenditure. E.A. Killion, D. Kong, A.S. Greenberg.
USDA at Tufts Univ. and Tufts Univ. Sackler Sch. of
Grad. Biomed. Sci. (267.8)
5:00 The Relationship between Dietary Protein Intake
Distribution and Lean Mass Loss in Free-Living Older
Adults: Effect of Sex and Total Protein Intake. S.
Farsijani, J.A. Morais, H. Payette, P. Gaudreau, B.
Shatenstein, K. Gray-Donald, S. Chevalier. McGill
Univ., Univ. of Sherbrooke, CHUMRC, Montreal and
Univ. of Montreal. (415.1)
5:00
Postprandial Glycemic and Insulinemic Responses to
Common Breakfast Beverages Consumed with a
Standard Meal in Overweight and Obese Individuals.
J. Li, E. Janle, W.W. Campbell. Purdue Univ. (1160.9)
5:00
Ablation of BCO2 Leads to Increased Susceptibility to
High Fat Diet-Induced Metabolic Disorders in Mice. L.
Wu, X. Guo, A. Davis, T.P. Soh, S. Clarke, E. Lucas,
B. Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma
5:00
Leucine in the Presence of Inflammation Alters BCAA
Metabolism in Human Myotubes. E.S. Riddle, H.
Roman, M. Ahsan, H. Shin, A. Thalacker-Mercer.
Cornell Univ. (430.7)
5:00 Altered Fatty Acid Metabolism Remodels the
Hypothalamic Metabolome to Stimulate Feeding
Behavior in BCO2 Knockout Mice. X. Guo, L. Wu,
T. Soh, W. Chowanadisai, S. Clarke, E. Lucas, B.
Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma
5:00
Effect of Plant Sources of Omega-3 PUFA on Mood
Status in Healthy Subjects: A Crossover Feeding
Trial. W.M. Young. Loma Linda Univ. (130.8)
5:00
Meta-analysis of Saturated Fatty Acid Intake and Breast
Cancer Risk. H. Xia, G. Sun, S. Wang. Sch. of Publ.
Hlth., Southeast Univ., China. (1163.14)
5:00
Effect of Stimulation to the Oral Cavity on Diet-Induced
Thermogenesis and the Substrate Oxidation of
Macronutrients. Y. Hamada, N. Hayashi. Grad.
Sch. of Decision Sci. and Technol., Tokyo Inst. of
Technol. (906.8)
5:00
Protein and Glutathione Kinetics in Protein Deficient
Piglets with Colitis in Response to Nutritional
Interventions: Protein Repletion or N-Acetylcysteine
Supplementation. M. Hong, J.Y. Xiao, E. Nitschmann,
L.J. Wykes. Sch. of Dietetics and Human Nutr., McGill
Univ. (685.4)
18
5:00Dietary α-Linolenic Acid-Rich Flax Oil Elevates Renal
and Hepatic Docsosahexaenoic Acid-Derived
Bioactive Lipids. J.G. Devassy, T. Yamaguchi, N.
Ibrahim, M. Gabbs, T. Winter, A. Ravandi, H.M.
Aukema. Univ. of Manitoba and St. Boniface Hosp.
Res. Ctr., Winnipeg. (267.5)
5:00
Modulation of Omega-3 Fatty Acid Profile in the Duck
Liver by Various Dietary Fats. X. Chen, X. Du, J.
Shen, L. Lu, W. Wang. Kansas State Univ., Zhejiang
Acad. Agr. Sci. and Zhejiang Zhuowang Agr. Sci-Tech
Ltd. Co., China. (1163.18)
5:00 Dairy
Milk
Components
Differentially
Affect
Gastrointestinal Health Markers in C57Bl/6 Mice. T.R.
Price, S.A. Baskaran, K. Moncada, Y. Minamoto, C.
Klemashevich, A. Jayaraman, J.S. Suchodolski,
R.L. Walzem. Texas A&M Univ. (685.2)
5:00
Impact of Vitamin D Status and High-Dose Vitamin D3
Administration on the Plasma Metabolome in Critically
Ill Adults. K. Perry-Walker, D.I. Walker, J.A. Alvarez,
J.E. Han, J.L. Jones, L. Hao, S. Li, K. Uppal, V.T.
Tran, L. Brown, V. Tangpricha, G.S. Martin, D.P.
Jones, T.R. Ziegler. Med. Col. of Georgia and Emory
Univ. (271.3)
5:00
Genes Associated with Amino Acid Sensing in Human
Skeletal Muscle Are Altered by Amino Acid Availability
and Acute Lysosomal Perturbation. T.G. Graber, M.S.
Borack, P.T. Reidy, E. Volpi, B.B. Rasmussen. Univ.
of Texas Med. Branch. (430.5)
5:00
Development of Nonalcoholic Fatty Liver in Superoxide
Dismutase-1 Knockout Mice Was Associated with
Altered Expression of Hepatic Fibroblast Growth
Factor-21. D. Chakraborty, X.G. Lei. Cornell
Univ. (267.7)
5:00
Assessing the Role of Saturated Fats in Adipose Tissue
Inflammation. M. Morgan-Bathke, W. Faubion, M.
Jensen. Mayo Clin. and Viterbo Univ., WI. (130.2)
5:00 Obesity and Dietary Fat Modulate HDL Function
in Adolescents: Results from a Cross-Sectional
Analysis and a Randomized, Placebo-Controlled,
Crossover Trial. A.M. McMorrow, M. O’Reilly,
R.M. Connaughton, E. Carolan, D. O’Shea, F.E.
Lithander, F.C. McGillicuddy, H.M. Roche. University
Col. Dublin, St Vincent’s Univ. Hosp., Dublin and Univ.
of Canberra. (130.6)
5:00
Citrulline Is a More Efficient Supplement Than Arginine
to Increase Systemic Arginine Availability in Mice. U.
Agarwal, I.C. Didelija, J.C. Marini. Baylor Col. of
Med. (430.6)
5:00
Predicting Initial Lipid Release from Masticated Tree
Nuts Using Mathematical Modelling. T. Grassby,
Y. Shen, L. Wagner, S. Beckett, W. Hall, S. Berry.
King’s Col. London. (405.6)
5:00
Metabolic Control of Cell Death : The Role of Bcl-xL.
H-A. Park, P. Licznerski, Y. Niu, N. Mnatsakanyan,
P. Miranda, J. Wu, S. Sacchetti, B.M. Polster,
K.N. Alavian, E.A. Jonas. Yale Sch. of Med., Univ.
of Maryland Baltimore and Imperial Col. London.
(1162.2)
5:00
Use of Plasma Metabolomics at Diagnosis to Identify
Metabolic Pathways Associated with Pulmonary
Tuberculosis Clearance: A Pilot Study. E. Chong,
J.K. Frediani, J.A. Alvarez, V. Tangpricha, H.M.
Blumberg, D.P. Jones, T. Yu, T.R. Ziegler. Emory
Univ. (271.8)
SATURDAYNUTRITION
5:00
Effects of Exercise, Caloric Restriction and Subsequent
Weight Regain following the Loss of Ovarian Function
on Mitochondrial Respiration. R. Oljira, M. Jackman,
R. Foright, J. Houck, G. Johnson, V. Sherk, P.S.
MacLean. Univ. of Colorado Sch. of Med. (906.13)
5:00 Protein Intake Is Associated with Plasma InsulinLike Growth Factor 1 in Postmenopausal Women
but Not in Premenopausal Women. K.N. Drake, J.
Foganholo, A. Brindisi, H. Samavat, K. Sturgeon,
K. Schmitz, M.S. Kurzer, A.Y. Arikawa. Univ. of North
Florida, Univ. of Minnesota, Saint Paul and Univ. of
Pennsylvania. (1164.3)
5:00
Early Childhood Predictors of Lifecourse BMI Latent
Class Trajectories in a Guatemalan Cohort. N.D.
Ford, M. Ramirez-Zea, R. Martorell, A.D. Stein.
Emory Univ. and Inst. of Nutr. of Central America and
Panama (INCAP), Guatemala. (33.2)
5:00
Access and Adoption of Nutrition Specific and Nutrition
Sensitive Messages in Ethiopia: A Qualitative
Gendered Comparison. M. Min-Barron. Friedman
Sch. of Nutr. Sci. and Policy, Boston. (274.1)
5:00
Predicted Effects of Current and Potential Micronutrient
Intervention Programs on Adequacy of Folate
and Vitamin B-12 Intake in a National Sample of
Women and Young Children in Cameroon. H. Luo,
C.P. Stewart, K.H. Brown, R. Engle-Stone. Univ.
of California, Davis and Bill & Melinda Gates Fndn.
(891.3)
5:00 Length-for-Age and Weight-for-Age z Scores at
Birth Using the World Health Organization Growth
Standards versus the New INTERGROWTH 21st
Newborn Size Standards. N. Perumal, J. Shi, D.
Bassani, A. Al-Mahmud, M.M. Islam, T. Ahmad, D.
Roth. Dalla Lana Sch. of Publ. Hlth., Univ. of Toronto,
Hosp. for Sick Children, Toronto and icddr,b, Dhaka,
Bangladesh. (432.3)
5:00
Determinants of Developmental Milestones in Infants
and Young Children in Bihar, India. L. Larson, R.
Mehta, P. Kekre, P. Verma, M.Young, A. Webb Girard,
U. Ramakrishnan, I. Chaudhuri, S. Srikantiah, R.
Martorell. Emory Univ. and CARE India, Patna. (44.5)
5:00 Oregano Essential Oil and Carvacrol Reduce
Cryptosporidium parvum Infectivity of HCT-8 Cells.
S. Gaur, T.B. Kuhlenschmidt, M.S. Kuhlenschmidt,
J.E. Andrade. Univ. of Illinois at Urbana-Champaign.
(668.12)
5:00 Non-responsive Feeding Behaviors Are Negatively
Associated with Growth and Dietary Diversity at
24 Months in Rural Bangladesh. Z.T. Chowdhury,
K.M. Hurley, M. Jahan, S. Shaikh, S. Mehra, H. Ali,
A.A. Shamim, P. Christian
Johns
Hopkins
Bloomberg Sch. of Publ. Hlth. and JiVitA Proj.,
Bangladesh. (432.8)
5:00 An Enteropathy Score Predicts Subsequent Length
Better Than Lactulose Mannitol Ratio Alone in
Children Enrolled in a Community-Based Randomized
Trial of Complementary Food Supplements in
Rural Bangladesh. R. Campbell, K. Schulze, S.
Shaikh, H. Ali, S. Mehra, L. Wu, P. Christian. Johns
Hopkins Bloomberg Sch. of Publ. Hlth. and JiVitA,
Bangladesh. (432.4)
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
Consumption of Novel Thiamin-Fortified Fish Sauce
Improves the Thiamin Status of Rural Cambodian
Women of Childbearing Age and Their Children <5
Years. K.C. Whitfield, C.D. Karakochuk, H. Kroeun,
B. Chan, M. Borath, L.D. Lynd, E.C.Y. Li-Chan, D.D.
Kitts, T.J. Green. Univ. of British Columbia, Helen
Keller Intl. - Cambodia, Ministry of Planning, Phnom
Penh and South Australian Hlth. and Med. Res. Inst.,
Adelaide. (891.9)
Social Support Enhances Adherence to Antenatal
Calcium
and
Iron-Folic Acid
Supplements:
Acceptability and Impact of Adherence Partners. S.
Martin, M. Omotayo, R. Stoltzfus, K. Dickin. Cornell
Univ. (150.3)
Effect of Short-Term Maternal Supplementation with
Small Amounts of Vitamin A or Beta-Carotene on
Breast Milk Retinol Concentrations among Lactating
Filipino Women. R. Engle-Stone, A. Osei, M.F.D.
Reario, A. Hall, J.E. Arsenault, N. Haselow, G. Lietz,
K.H. Brown, M.J. Haskell. Univ. of California, Davis,
Helen Keller Intl., NY, Newcastle Univ., U.K. and Bill &
Melinda Gates Fndn., Seattle. (150.7)
Large-Scale Television Campaign Associated with
Higher Prevalence of Exclusive Breastfeeding in
Vietnam. T.T. Nguyen, S. Alayón, P.H. Nguyen, A.
Jimerson, N. Hajeebhoy, J. Baker, E.A. Frongillo.
FHI 360, Hanoi, FHI 360, Save the Children and IFPRI,
Washington, DC and Univ. of South Carolina. (274.8)
High Prevalence of Low Urinary Iodine among Pregnant
and Lactating Women of Bangladesh Does Not
Respond to Daily Lipid-Based Nutrient Supplement
Containing 250 µg Iodine. M.K. Mridha, S.L. Matias,
S.A. Khan, R.R. Paul, Z. Siddiqui, B. Ullah, S.
Hussain, R.T. Young, C.D. Arnold, K.G. Dewey.
Univ. of California, Davis, ICDDR,B, Care Bangladesh
and Save the Children, Dhaka, Bangladesh. (150.4)
Physical Activity and Work Productivity in Response to
Iron and Iodine Double-Fortified Salt Trial in Indian
Tea Estate Workers. M.M. Blakstad, J.E.H. Nevins,
S. Venkatramanan, E.M. Przybyszewski, J.D. Haas.
Cornell Univ. and McGill Univ., Ste. Anne de Bellevue.
(150.5)
Prebiotic Diet Modulates Gut Microbial Composition and
Metabolic Functions in Metabolic Syndrome Patients:
Follow-Up of a Double Blind, Controlled, Crossover
Intervention. B. Upadhyaya, R. Juenemann, L.
McCormack, A.R. Fardin-Kia, J. Clapper, S.
Nichenametla, B. Specker, M. Dey. South Dakota
State Univ. and USDA, College Park, MD. (419.4)
Gastrointestinal Microbial Changes following Whole
Grain Barley and Oat Consumption in Healthy Men
and Women. S.V. Thompson, K.S. Swanson, J.A.
Novotny, D.J. Baer, H.D. Holscher. Univ. of Illinois at
Urbana-Champaign, USDA, Beltsville, MD. (406.1)
Three Doses of Vitamin D on Insulin Resistance and
Osteocalcin Measures in Older Women. L.C. Pop,
S.H. Schneider, D. Sukumar, Y. Schlussel, S.A.
Shapses. Rutgers Univ., Rutgers-Robert Wood
Johnson Med. Sch. and Drexel Univ. (419.8)
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Modulation of Colonic Microbiota Populations by
Polyphenolic Containing Sorghum Brans May Protect
against Development of Metabolic Disease. S.K.
Lloyd, L.E. Ritchie, K.K. Hicks, M.A. Azcarate-Peril,
N.D. Turner. Texas A&M Univ. and Univ. of North
Carolina Sch. of Med. (683.4)
Pectin Feeding for 16 Weeks Improves Learning and
Memory in Young C57BL/6_J Mice: A Relationship
to the Gut Microbiota? L. Mailing, J. Allen, T-W. Liu,
T. Bhattacharya, P. Park, B. Pence, J. Rodney, G.
Fahey, K. Swanson, J. Rhodes, J. Woods. Univ. of
Illinois at Urbana-Champaign. (683.10)
Prospective Association of Fasting Blood Glucose Levels
with Risk of Incident Stroke among Hypertensive
Patients in China: Impact of Folic-Acid Intervention.
R. Xu, X. Kong, B. Xu, M. Ji, Y. Zhang, B. Wang, F.F.
Hou, J. Ge, Y. Huo, J. Li. River Hill H.S., Clarksville,
MD, Peking Univ. First Hosp., Beijing, Zhongshan
Hosp., Fudan Univ., China, Nanfang Hosp., So. Med.
Univ., China. (419.6)
Influence of Daily and Per Meal Protein Intakes on
Function and Body Composition in Frail, Obese Older
Adults Undergoing Weight Reduction. K.N. Porter
Starr, M.C. Orenduff, S.R. McDonald, C.F. Pieper,
H.C. Mulder, K. Maloney, C.W. Bales. Duke Univ.
Med. Ctr. and Durham VA Med. Ctr. (419.1)
Differences in the Infant Gut Microbiota Related to the
Fatty Acid Composition of Human Milk: Results from
the GEHM Cohort. D.H. Taft, K.A. Dingess, C.J.
Valentine, B.S. Davidson, N.J. Ollberding, D.V.
Ward, J.T. Brenna, R.J. McMahon, A.L. Morrow.
Cincinnati Children’s Hosp. and Med. Ctr., Mead
Johnson Nutr., Glenview, IL, Univ. of Massachusetts
Med. Sch. and Cornell Univ. (406.7)
Formula Milk Alters Microbial Diversity in Porcine Colon
and Impacts Immune Response. M.K. Saraf, A.K.
Bowlin, S.V. Chintapalli, K. Shankar, T. LeRoith,
M.J. Ronis, T.M. Badger, L. Yeruva. Arkansas
Children’s Nutr. Ctr., Univ. of Arkansas for Med. Sci.,
VA-MD Col. of Vet. Med. and LSU Hlth. Sci. Ctr., New
Orleans. (406.8)
Impact of Almond Consumption on the Composition
of the Gastrointestinal Microbiota of Healthy Adult
Men and Women. A.M. Taylor, K.S. Swanson, J.A.
Novotny, D.J. Baer, H.D. Holscher. Univ. of Illinois
at Urbana-Champaign and USDA, Beltsville, MD.
(406.5)
Perceived Breastmilk Insufficiency and HIV Are
Associated with Exclusive Breastfeeding at 1 and 3
Months among Mothers in Northern Uganda. S.L.
Martin, S.M. Collins, E.M. Widen, D. Achidri, S.L.
Young. Cornell Univ., Columbia Univ. and PRENAPS
Uganda, Gulu. (45.7)
Impact of Maternal Infection and Breast Inflammation
on Infant Growth in Guatemala. H.M. Wren, A.L.
Leblanc, C. Li, N.W. Solomons, M.E. Scott, K.G.
Koski. McGill Univ., St-Anne-de-Bellevue, Montreal
and CeSSIAM, Guatemala City. (45.6)
Women with a Common Genetic Variant in ZnT2 (T288S)
Have Altered Breast Milk Composition: Implications
for Suboptimal Lactation. S. Lee, C. Dalrymple, S.L.
Kelleher. Penn State Hershey Col. of Med. (673.1)
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
Lean Mass Accretion Associates with Vitamin D Intake:
A 6 Month Randomized Controlled Trial in 2-8 Year
Olds Using Fortified Foods. N.R. Brett, C.A. Parks,
P. Lavery, S. Agellon, C.A. Vanstone, J.L. Maguire,
F. Rauch, H.A. Weiler. Sch. of Dietetics and Human
Nutr., McGill Univ., Li Ka Shing Inst. of St. Michael’s
Hosp., Univ. of Toronto and Shriners Hosp. for
Children, McGill Univ. (151.3)
Erythrocyte Omega-3 Long Chain Polyunsaturated
Fatty Acids Are Associated with Lumbar Spine but
Not Whole Body Bone Mineral Density in Healthy
Children. C.A. Parks, N.R. Brett, S. Agellon, P.
Lavery, C.A. Vanstone, J.L. Maguire, F. Rauch, H.A.
Weiler. Sch. of Dietetics and Human Nutr., McGill
Univ., Li Ka Shing Knowledge Inst. of St. Michael’s
Hosp., Univ. of Toronto and McGill Univ., Montreal.
(151.4)
Eating, Feeling, and Feeding: Does Maternal Binge
Eating Predict Use of Child Feeding Practices
through Emotional Responsiveness? J.A. Saltzman,
M. Pineros-Leano, J.M. Liechty, K.K. Bost, B.H.
Fiese. Sch. of Social Work, Univ. of Illinois, Urbana.
(1150.12)
Role of Human Milk Oligosaccharides in Feto-placental
Endothelial Function in Gestational Diabetes Mellitus.
E. Jantscher-Krenn, J. Aigner, U. Lam, M. van
Poppel, L. Bode, G. Desoye. Med. Univ. of Graz,
Univ. of Graz, Austria and UCSD. (275.6)
Mammary Gland Structure and Functional Changes
in Mouse Model of Chronic Gestational Alcohol
Exposure. R.M. Amos-Kroohs, A.A. Cheng, R.D.
Clugston, T-N. Huang, C-L. Yen, W.S. Blaner, S.M.
Smith. Univ. of Wisconsin-Madison and Columbia
Univ. (275.4)
INSIGHT Study Parenting Intervention to Prevent
Childhood Obesity Improves Patterns of Dietary
Exposures in Infants. E.E. Hohman, J.S. Savage, I.M.
Paul, L.L. Birch. Penn State, Penn State Col. of Med.
and Univ. of Georgia. (295.2)
Calcium Absorption among Racially Diverse Pregnant
Women. M.N.R. Lesser, L. Nguyen, J.C. King, K.O.
O’Brien, E.B. Fung. Children’s Hosp. Oakland Res.
Inst., Univ. of California, Berkeley and Cornell Univ.
(45.1)
Association between Breastfeeding, Maternal Weight
Loss and Body Composition at 3 Months Postpartum.
S.A. Elliott, L.C.R. Pereira, E. Guigard, L.J.
McCargar, C.C.M. Prado, R.C. Bell. Univ. of Alberta.
(45.4)
Standing by Human Milk through Thick and Thin: The
Effect of Thickeners on Human Milk Viscosity. J.K.
Koo, L. Bode, J.H. Kim. UCSD/Rady Children’s
Hosp. of San Diego. (151.5)
Using Skin Carotenoids to Assess Potential Dietary
Changes after One Academic Year in the Shaping
Healthy Choices Program. L.M. Nguyen, R.E.
Scherr, M. Dharmar, I.V. Ermakov, W. Gellermann,
L. Jahns, J.D. Linnell, C.L. Keen, S. Miyamoto, F.M.
Steinberg, H.M. Young, S. Zidenberg-Cherr. Univ. of
California, Davis, Sch. of Nursing, Davis Hlth. Syst.,
Sacramento, Image Technols. Corp., Salt Lake City,
USDA, Grand Forks, Univ. of California Agr. and Nat.
Resources and Penn State Col. of Nursing. (896.19)
SATURDAYNUTRITION
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Observed Differences in Child Picky Eating Behaviors
between the Child’s Home and Center- or HomeBased Childcare. V. Luchini, S-Y. Lee, S. Donovan.
Univ. of Illinois at Urbana-Champaign. (895.13)
Peer-Education about Weight Steadiness (PAWS Club):
Pilot Test of Family Menu Planning Lesson for Parents
and Their Young Adolescents. C.J. Nikolaus, C.A.
Liguori, A.N. Winslow, S.M. Nickols-Richardson.
Univ. of Illinois at Urbana-Champaign. (896.18)
Adolescents with At-Risk Eating and Lifestyle Behaviors
Are Impacted by After-School Schedules across
the Clinical Weight Spectrum. L. Perez, C.K. Miller,
J.A. Groner. The Ohio State Univ. and Nationwide
Children’s Hosp. (1155.11)
Fluid Intake in Male Brazilian Teens According to
Recommendations for Age, BMI and Physical Activity
Patterns – The Fitfood Study. R.H.V. Machado, I.
Iglesia, C. Martinelli, A.C.L. Rocha, C.A. Hartwick,
A. Pires, M. Fisberg, L. Moreno. Sabara Children’s
Hosp./José Luiz Egydio Setubal Fndn., São Paulo,
Univ. of Zaragoza, Spain, Danone Res. and Danone
Inst. Intl., Paris and Fed. Univ. of São Paulo. (1155.9)
Evaluating the Young Adult Motivation to Prepare
Healthy Foods Questionnaire Using Exploratory
Factor Analysis. A.D. Bailey, D. Miketinas, M. Cater,
B. Zawodniak, G. Tuuri. LSU and LSU AgCtr. (676.11)
Participants in the Shaping Healthy Choices Program
Increased the Intensity of Physical Activity. D.S.
Fetter, R.E. Scherr, J.D. Linnell, M. Dharmar, S.E.
Schaefer, K.M. Brian, S. Zidenberg-Cherr. Univ. of
California, Davis, Sch. of Nursing, Davis Hlth. Syst.,
Sacramento, Agr. and Nat. Resources, Davis and
Coop. Ext., Auburn, CA. (895.10)
Nudges: Fun, Motivational Messages to Encourage and
Reassure Parents in the Homestyles Randomized
Controlled Trial. C. Delaney, J.T. Martin-Biggers,
G. Povis-Alleman, N. Hongu, J. Worobey, C. ByrdBredbenner. Rutgers Univ. and Univ. of Arizona.
(896.15)
Nutrition Recommendations Critical to Teach LowIncome Adults in EFNEP: U.S. Dietary Guidelines
Expert Panel Opinion. E. Murray, S. Baker, G. Auld.
Colorado State Univ. (896.16)
Validation of Two Brief Questionnaires Designed to
Assess Fruit and Vegetable Intake among 3rd-5th
Grade SNAP-Ed Participants. Y. Zhang, G. Hurtado,
M. Reicks. Univ. of Minnesota-Twin Cities. (896.9)
Parent and Adolescent Child Perceptions of a Grocery
Store Tour: Comparison of Adult- versus Teen-Led
Education. C.J. Nikolaus, C.A. Liguori, S.M. NickolsRichardson. Univ. of Illinois at Urbana-Champaign.
(896.14)
Effects of an Educational Group Intervention for Patients
with Type 2 Diabetes on Lifestyle and Glycemic
Control. L.M. Sterpone, K. Haua-Navarro, A.B.
Perez-Lizaur. Univ. Iberoamericana, Mexico City.
(676.10)
Culinary Skills Intervention: Immediate Impacts on
Knowledge, Attitudes and Self-Efficacy in Adolescent
Youth. A.R. Oakley, S.M. Nickols-Richardson. Univ.
of Illinois at Urbana-Champaign. (896.6)
5:00
Perceptions, Beliefs, and Implementation of the Dietary
Guidelines for Americans Consumer Messages by
Low-Income Parents. M. Chea, A.R. Mobley. Univ. of
Connecticut. (896.7)
5:00
The Effects of Nutrition Education on Fruit and Vegetable
Consumption in Food Pantry Clients. S. St. Cyr, A.
Bruzina, M. Linek, M. Butsch-Kovacic, S-Y. Lee.
Univ. of Cincinnati and Cincinnati Children’s Hosp.
Med. Ctr. (896.17)
5:00
Teacher Characteristics Influence Implementation of a
Multi-component, School-Based Nutrition Intervention
in Fourth-Grade Classrooms. J.D. Linnell, M.H. Smith,
M. Briggs, K.M. Brian, R.E. Scherr, M. Dharmar, S.
Zidenberg-Cherr. Univ. of California, Davis, Placer
and Nevada Counties Coop. Ext., Auburn and Univ.
of California Davis Hlth. Syst., Sacramento. (1155.8)
5:00 Comparing Dietary Strategies to Increase Vegetable
Consumption: Encouraging Tomato Products versus
Raw Vegetable Consumption. S. Rahman, E. Park,
K. Reimers, B.M. Burton-Freeman. Illinois Inst. of
Technol. and ConAgra Foods, Omaha. (895.9)
5:00 MicroRNAs as a Novel Mechanism by Which
Eicosapentaenoic Acid Mediates Inflammation in
Diet-Induced Obesity. E. Yen, N. Wijayatunga, M.
Pahlavani, L. Ramalingam, K.R. Kottapalli, N.S.
Kalupahana, P. Gunaratne, K. Rajapakshe, C.
Coarfa, S. Dharmawardhane, N. Moustaid-Moussa.
Texas Tech Univ., Univ. of Sri Jayewardenepura and
Univ. of Peradeniya, Sri Lanka, Univ. of Houston,
Baylor Col. of Med. and Univ. of Puerto Rico-Med.
Sci. Campus. (911.7)
5:00
Depletion of Dietary MicroRNAs from Cow’s Milk Causes
5:00 Gene, Sex and Diet Interact to Control the Tissue
Metabolome. A. Wells, W. Barrington, D. Threadgill,
S. Dearth, S. Campagna, A. Saxton, B. Voy. Univ. of
Tennessee and Texas A&M Univ. (127.2)
5:00 A Genome-Wide Association Study of Plasma α2Macroglobulin Concentrations in Young Adults. J.
Jamnik, C. Borchers, A. El-Sohemy. Univ. of Toronto
and Univ. of Victoria, Canada. (127.3)
5:00 Differential DNA Methylation between Obese and
Normal Weight Women in CD4+ and CD8+ T Cells,
and CD16+ Neutrophils. N.M. Hohos, A.K. Smith, V.
Kilaru, H.J. Park, D.B. Hausman, L.B. Bailey, R.D.
Lewis, R.B. Meagher. Univ. of Georgia and Emory
Univ. (431.1)
5:00 Effects of Maternal Vitamin D Deficiency on
Fetal Epigenetic Reprogramming. J. Xue, F.Y.
Ideraabdullah. Univ. of North Carolina at Chapel Hill.
(912.1)
5:00 Monounsaturated Fatty Acids Impede Inflammation
Partially through Activation of AMPK. C.L. Lyons, O.F.
Finucane, A.M. Murphy, A.A. Cooke, B. Viollet, P.M.
Vieira, W. Oldham, B.B. Kahn, H.M. Roche. Conway
Inst. of Biomolec. and Biomed. Res., Dublin, Inst.
Cochin, INSERM, Paris, Beth Israel Deaconess Med.
Ctr., Harvard Med. Sch. and Brigham and Women’s
Hosp. (296.5)
21
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Effect of a Diet Rich in Whole Grains on Gut Microbiota,
and Immune and Inflammatory Markers of Healthy
Adults. S.M. Vanegas, M. Meydani, J.B. Barnett,
A. Kane, B. Goldin, D. Wu, J.P. Karl, C. Brown, P.
Vangay, D. Knights, L. Li, S.S. Jonnalagadda, M.
Thomas, E. Satlzman, S.N. Meydani. USDA and Sch.
of Med., Tufts Univ., Univ. of Minnesota, Minneapolis
and General Mills, Minneapolis. (296.8)
Vitamin a Supplementation and LipopolysaccharideInduced Inflammation in the Neonate a Pilot Study
in C57BL/6 Mice. C-H. Wei, A.C. Ross. Penn State.
(916.2)
Feeding a Maternal Diet Enriched in Docosahexaenoic
Acid to Lactating Dams Improves the Ex Vivo
Tolerance Response to Egg Protein in Suckled Pups.
C. Richard, E.D. Lewis, S. Goruk, C.J. Field. Univ. of
Alberta. (296.6)
Effects of a Randomized, Controlled Trial of Daily
Vitamin D3 Supplementation during Pregnancy on
Regulatory Immunity and Inflammation. M. Zerofsky,
B. Jacoby, T.L. Pedersen, C.B. Stephensen. USDA,
Davis and UC Davis Med. Ctr., Sacramento. (296.7)
The Impact of Environmental Enteropathy and Systemic
Inflammation on Infant Growth Failure. C. Naylor, M.
Lu, J.A. Ma, A.M. Prentice, W.A. Petri. MRC Unit,
The Gambia, Univ. of Virginia and London Sch. of
Hyg. and Trop. Med. (296.4)
Dietary Supplementation with Montmorency Tart Cherry
Prevents the Alterations in Gut Mucosal Immunity
That Occurs with Ovarian Hormone Deficiency. E.K.
Crockett, J.L. Graef, P. Ouyang, S.L. Clarke, U.
DeSilva, E.A. Lucas, B.J. Smith. Oklahoma State
Univ. (916.14)
Mapping Inflammation and Cancer-Modifying Regions in
Broccoli Genome. W. Bussler, J. Alley, H. Chandler,
C. Thetford, G. Yousef, A. Brown, D. Esposito,
M.A. Lila, S. Komarnytsky. North Carolina State
Univ., Kannapolis and Raleigh, Iowa State Univ. and
Catawba Col., NC. (131.8)
Adherence to the 2015 Dietary Guidelines for Americans
and Risk of Healthy and Unhealthy Obesity among
Canadian Adults. M. Jessri, W. Lou, M. L’Abbe. Dalla
Lana Sch. of Publ. Hlth., Univ. of Toronto. (131.3)
Improving the Food Supply by Product Reformulation:
Using Nutrient Profiling to Evaluate Foods Consumed
in the USA. F. Mölenberg, A. Vlassopoulos, G.
Masset, U. Lehmann. Wageningen Univ., Netherlands
and Nestle Res. Ctr., Lausanne. (681.7)
Development of Novel Hollow Zein Nanoparticles for
Delivery of Nutraceuticals. S. Hu, M-L. Fernandez, Y.
Luo. Univ. of Connecticut. (680.9)
Analysis of Polycyclic Aromatic Hydrocarbons for
Reduction in Simple-Processed Foods According
to Manufacturing System. S-J. Kang, S-Y. Yang,
K-W. Lee. Col. of Life Sci. and Biotechnol., Korea
Univ. (680.8)
Are Foods of Higher Nutritional Quality More Expensive
Than Their Less Healthy Counterparts? An Analysis
of Canadian Packaged Foods. M-E. Labonté, S.
Noorhosseini, J. Bernstein, M. Ahmed, M. L’Abbé.
Univ. of Toronto. (131.7)
5:00 Berberine Ameliorates Hepatic Steatosis and
Suppresses Liver and Adipose Tissue Inflammation
in Obesity Mice Independent of AMPK. S-L. Woo, T.
Guo, X. Guo, H. Li, J. Zheng, R. Botchlett, Y. Cai,
X. Li, Q. Li, X. Xiao, Y. Huo, C. Wu. Texas A&M Univ.,
Hubei Hosp. of Chinese Med., Wuhan, The First Hosp.
of CMU, China and Georgia Regents Univ. (126.5)
5:00
Orbitofrontal Cortex Response to Food Portion Size Is
Linked with Obesogenic Appetitive Profile in Children.
L.K. English, S.N. Fearnbach, M. Lasschuijt, S.J.
Wilson, M. Tanofsky-Kraff, B.J. Rolls, K.L. Keller.
Penn State, Wageningen Univ., Netherlands and
Uniformed Svcs. Univ. of Hlth. Sci., Bethesda. (270.3)
5:00
Weight Gain with Metabolic Dysfunction Is Associated
with Obesity-Related Cancer. S. Chadid, M.R. Singer,
B.E. Kreger, L.L. Moore. Boston Univ. Sch. of Med.
(910.4)
5:00 Secretory Factors Produced by Stromal Cultures of
Human Omental Adipose Tissue Inhibit Adipose
Differentiation. R.T. Pickering, M-J. Lee, M. Jager, M.
Layne, S.K. Fried. Boston Univ. Sch. of Med. (126.7)
5:00 Soy Positively Impacts Cecal Microbiota of
Ovariectomized Rats Selectively Bred for Low Aerobic
Capacity. T-W. Liu, T.M. Zidon, R.J. Welly, Y-M. Park,
S.L. Britton, L.G. Koch, J. Padilla, V.J. Vieira-Potter,
K.S. Swanson. Univ. of Illinois, Urbana, Univ. of
Missour-Columbiai and Univ. of Michigan. (146.1)
5:00 Relationship between Human Gut Microbiota and
Interleukin 6 Levels in Overweight and Obese Adults.
D. Cooper, E.B. Kim, M. Marco, B. Rust, L. Welch, W.
Horn, R. Martin, N. Keim. Univ. of California, Davis,
USDA, Davis and Seoul Natl. Univ. (146.4)
5:00 Does Milk Portion Size or Energy Density Affect
Preschool Children’s Lunch Intake? S.M.R. Kling,
L.S. Roe, B.J. Rolls. Penn State. (270.1)
5:00 Comparison of MRI and DXA for Measurement of
Visceral Adipose Tissue in Adolescent Females. S.L.
Belcher, J.M. Kindler, N.K. Pollock, H.L. Ross, C.M.
Modlesky, E.M. Laing, R.D. Lewis. Univ. of Georgia,
Med. Col. of Georgia-Georgia Regents Univ. and
Univ. of Delaware. (686.8)
5:00 Energy Expenditure in Children with Prader-Willi
Syndrome during Walking. F.A. Chavoya, A.
Slowetzky-Amaro, D. Castner, A. Hyde, J. Ramirez,
A. Wong, V. Layvant, D. Rubin. California State Univ.,
Fullerton. (687.2)
5:00 Gut Microbiota Metabolites in Infancy: Associations
with Breastfeeding and Childhood Overweight. S.
Bridgman, P. Koleva, R. Mandal, M. Azad, C. Field,
A. Haqq, A. Becker, S. Turvey, P. Mandhane, P.
Subbarao, M. Sears, D. Wishart, A. Kozyrskyj. Univ.
of Alberta, Univ. of Manitoba, Univ. of British Columbia,
Univ. of Toronto and McMaster Univ., Canada. (146.3)
5:00 Effects of an Almond-Enriched Energy Restricted
Diet on Body Composition, Visceral Adipose Tissue
and Blood Pressure in Obese Adults. J. Dhillon, R.
Mattes. Purdue Univ. (146.8)
5:00
Differences in Plasma Metabolites in Insulin Resistant
and Insulin Sensitive Obese Individuals during a
Hyperinsulinemic/Euglycemic Clamp. J.L. Casey,
D.W. Van Pelt, C. Burant, J. Horowitz, C. Evans.
Univ. of Michigan Sch. of Publ. Hlth. and Sch. of
Kinesiol. (889.3)
SATURDAYNUTRITION
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Therapeutic Potential of AICAR in Attenuating ObesityInduced Metabolic, Liver and Kidney Disease. E.
Borgeson, V.W. Borgeson, C. Godson, K. Sharma.
Univ. of Gothenburg, Sweden, University Col. Dublin,
Ireland and UCSD. (126.4)
Network Social Support for Healthy and Obesogenic
Behavior Influences Children’s Dietary Intake and
Weight Change during Family-Based Behavioral
Obesity Treatment. K.N. Balantekin, J.F. Hayes, R.P.
Kolko, R.I. Stein, B.E. Saelens, R.R. Welch, M.G.
Perri, K.B. Schechtman, L.H. Epstein, D.E. Wilfley.
Washington Univ. Sch. of Med., Univ. of Pittsburgh,
Seattle Children’s Hosp., Univ. of Florida and Univ. at
Buffalo. (270.5)
Improved Bioavailability of Iron from Amino Acid
Chelates in Fully Differentiated Human Intestinal
Epithelial (Caco-2) Cells. C. Doguer, N. Shay, J.F.
Collins. Univ. of Florida and Oregon State Univ.
(918.4)
High Dietary Iron Intake Impairs Growth and Causes
Copper Deficiency in Sprague-Dawley Rats. J-H.
Ha, C. Doguer, S. Zhao, X. Wang, S.R. Flores, J.F.
Collins. Univ. of Florida. (292.4)
Lack of Intestinal Divalent Metal-Ion Transporter 1
Perturbs Copper Homeostasis in Mice. X. Wang, S.
Flores, J-H. Ha, C. Doguer, J.F. Collins. Univ. of
Florida. (292.1)
Maternal Choline Supplementation Modulates Maternal
and Fetal Choline Metabolism and Downregulates
Inflammatory Gene Expression in a Mouse Model of
Placental Insufficiency. J.H. King, S.T. Kwan, J. Yan,
X. Jiang, V.G. Fomin, M.S. Roberson, M.A. Caudill.
Cornell Univ. and Brooklyn Col. (272.1)
Lower Hepatic Iron Storage Associated with Obesity in
Mice Can Be Restored by Decreasing Body Fat Mass
through Feeding a Low Fat Diet. H. Chung, D. Wu, D.
Smith, S.N. Meydani, S.N. Han. Seoul Natl. Univ. and
USDA at Tufts Univ. (1173.3)
Iron Status and Regulation in High-Risk Pregnant
African American Women. L. Welke. Univ. of Illinois at
Chicago. (292.5)
High Iron Diet during Prenatal Alcohol Exposure (PAE)
May Normalize Iron Homeostasis in PAE Fetuses.
A.A. Cheng, S.M. Huebner, S.M. Smith. Univ. of
The AHR Pathway and Its Potential Role in the
Regulation of the 15 kDa Selenoprotein. S.E.
Galinn, L.E. Rosso, B.A. Carlson, R. Tobe, S.
Naranjo-Suarez, P.A. Tsuji. Towson Univ., NCI, NIH,
Ritsumeikan Univ., Japan and Johns Hopkins Univ.
(1170.5)
Zinc-Induced Upregulation of Metallothionein-2A Is
Predicted by Gene Expression of Zinc Transporters
in Healthy Adults. A. Chu, M. Foster, S. Ward, K.
Zaman, D. Hancock, P. Petocz, S. Samman. Univ. of
Otago, New Zealand, Univ. of Sydney and Macqurie
Univ., Australia. (148.1)
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
5:00
Effect of High Folic Acid Diet on Mitochondrial DNA
Content in Young Adult and Aged Mice. J. Mustra
Rakic, H. Sawaengsri, C. Reginaldo, J. Selhub, L.
Paul. USDA and Tufts Univ. (1171.4)
Iron-Dependent Regulation of Cytoglobin in Neuro 2A
Cells. J. Fiddler, T. Soh, M. Davis, W. Chowanadisai,
S. Clarke. Oklahoma State Univ. and Midwestern
Univ., AZ. (1173.4)
1,25-Dihydroxyvitamin D Regulates Energy Substrate
Metabolism to Reduce Triacylglycerol Accumulation
in 3T3-L1 Adipocytes. B.M. Larrick, K-H. Kim, S.S.
Donkin, D. Teegarden. Purdue Univ. (128.2)
Characterization of Cystathionine Beta-Synthase and
Cystathionine Gamma-Lyase in the Production of
Hydrogen Sulfide Biomarkers, Lanthionine and
Homolanthionine, in a HepG2 Cell Culture Model.
B. DeRatt, M. Ralat, J. Gregory. Univ. of Florida.
(1171.5)
Prevalence and Determinants of Suboptimal Vitamin B6
Status in Young Adult Women in Metro Vancouver.
C-l. Ho, T.A.W. Quay, J.L. Black, A.M. Devlin, Y.
Lamers. Univ. of British Columbia, Child and Family
Res. Inst., Vancouver and Fraser Hlth. Authority,
Surrey, Canada. (1171.6)
Zinc and ZIP14 (Slc39a14) Are Required for Adaptation
to ER Stress in Mouse Liver. M-H. Kim, T.B. Aydemir,
R.J. Cousins. Univ. of Florida. (148.2)
Dietary Glycine Alters One-Carbon Metabolic Kinetics In
Vivo. Y-H. Huang, E-P.I. Chiang. Natl. Chung Hsing
Univ., Taiwan. (272.4)
Effect of Vitamin D Fortified Cheese on Oral Glucose
Tolerance in Individuals Exhibiting Marginal Vitamin
D Status and an Increased Risk for Developing Type
2 Diabetes: A Double-Blind, Randomized PlaceboControlled Clinical Trial. T.S. Moreira-Lucas, A.M.
Duncan, R. Rabasa-Lhoret, R. Vieth, A. Gibbs, A.
Badawi, T.M.S. Wolever. Univ. of Toronto, Univ. of
Guelph, Canada, Clin. Res. Inst. of Montreal and
Publ. Hlth. Agcy. of Canada, Toronto. (917.1)
Hepcidin Attenuates Zinc Efflux in Caco-2 Cells. S.R.
Hennigar, J.P. McClung. U.S. Army Res. Inst. of
Envrn. Med., Natick, MA. (292.3)
Novel Role of Glutathione Peroxidase-1 in Liver and
Muscle Protein Metabolism of Mice. L. Tao, Z.P. Zhao,
X.G. Lei. Cornell Univ. (148.5)
Vitamin B12 and Placental Expression of Transcobalamin
in Pregnant Adolescents. A.J. Layden, K.O. O’Brien,
E.K. Pressman, T.R. Kent, J.L. Finkelstein. Cornell
Univ., Univ. of Rochester Med. Ctr. and St. John’s
Res. Inst., Bangalore. (272.3)
23
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PATHOLOGYSATURDAY
Pathology
48.
MOLECULAR AND CELLULAR BASIS OF
DISEASE: FROM PREVENTION TO CANCER
METASTASIS: THE BIOLOGY AND THERAPY OF
BREAST CANCER METASTASIS
Symposium
(Supported by unrestricted educational grants from
Elsevier and Friends for an Earlier Breast Cancer Test)
(Sponsored by: the ASIP Breast Cancer and Tumor
Microenvironment & Metastasis Scientific Interest Groups)
Sat. 8:30 am—San Diego Convention Center, Room 2
Chaired: B. Felding
Cochaired: W.B. Coleman
Cancer Biology
Breast Cancer
Neoplasia
8:30
Targeting the Tumor Microenvironment in Breast Cancer.
D. Panigrahy. Beth Israel Deaconess Med. Ctr.
9:15
Breast Cancer Brain Metastasis: Molecular Subtypes
and Prognosis. S. Wei. Univ. of Alabama at
Birmingham Sch. of Med.
10:00 Metabolism in Breast Cancer Brain Metastasis. S.
Kesari. UCSD.
10:45 Mechanisms of Breast Cancer Metastasis and
Opportunities for Intervention. B. Felding. The
Scripps Res. Inst.
49.
PATHOBIOLOGY FOR BASIC SCIENTISTS:
METABOLISM RUN AMOK: UNDERSTANDING
BIOCHEMICAL PATHWAYS AND THEIR
PATHOLOGIC CONSEQUENCES IN CANCER
AND SYSTEMS BIOLOGY
Course
(Sponsored by: the ASIP Education Committee )
Chaired: W. Mars
Cochaired: R.N. Mitchell
Cancer Biology
Metabolism and Metabolic Disease
Microbiome
8:30 Tumor
Metabolic
Pathways;
Warburg
Effect
(Glioblastoma as a Model). P. Mischel. UCSD Sch.
of Med.
9:30
How the Microbiome Influences Human Metabolism. G.
Siuzdak. The Scripps Res. Inst.
10:30 Obesity, Metabolic Syndrome, and Non-alcoholic
Steatohepatitis. D. Cohen. Harvard Med.Sch.
24
50.
EMERGING TRANSLATIONAL PATHWAYS IN
PULMONARY PATHOLOGY
Minisymposium
Chaired: S.H. Phan
Pulmonary Pathobiology
8:30
Current Overview of Pulmonary Fibrosis.
8:45 50.1
Neutrophil Extracellular Traps Drive BleomycinInduced Lung Fibrosis by Regulating TGFβ1-Dependent
Interactions of Platelets and Macrophages. D.R. Riehl, J.
Roewe, S. Klebow, N.L. Esmon, S. Eming, G. Colucci, K.
Schäfer, M. Gunzer, A. Waisman, P.A. Ward, C.T. Esmon, M.
Bosmann. Univ. Med. Ctr. Mainz, Oklahoma Med. Res. Fndn.,
Univ. of Cologne, Clin. Luganese Moncucco, Switzerland, Univ.
Duisburg-Essen, Germany and Univ. of Michigan Med. Sch.
9:00 50.2
Dimethyl Fumarate Ameliorates Pulmonary
Hypertension In Vivo and Prevents Fibrosis via βTRCP-Mediated
Degradation of β-Catenin and TAZ. A. Grzegorzewska, R. Han,
F. Seta, L. Stawski, C. Feghali-Bostwick, J. Browning, M.
Trojanowska. Boston Univ. and Med. Univ. of South Carolina.
9:15 50.3
Allergen-Induced Endoplasmic Reticulum
Stress Regulates Lung Inflammation and Fibrosis. S. Jalahalli
Mariswamy, E.M. Nakada, B. Mihavics, S. Hoffman, D.
Chapman, C.G. Irvin, A. Dixon, M. Poynter, V. Anathy. Univ.
of Vermont.
9:30 50.4
Organic Cation Transporter Novel Type-1 and
Pulmonary Responses to Secondhand Tobacco Smoke. D.C.
Milner, J.B. Lewis, D.R. Winden, J. Gassman, T. Monson, D.
Broberg, J.A. Arroyo, P.R. Reynolds. Brigham Young Univ.
and Roseman Univ. of Hlth. Sci.
9:45 50.5
Knockdown
Glucose-6-Phosphate
Dehydrogenase Promotes EMT through Downregulation of
E-Cadherin by miR-200b Inhibition in A549 Cells. Y-H. Wu, Y-H.
Lee, D.T-Y. Chiu. Chang Gung Univ. and Chang Gung Mem.
Hosp., Taiwan.
10:00 50.6
Amphiregulin Promotes Fibroblast Activation
in Pulmonary Fibrosis. T. Liu, F. Gonzalez De Los Santos, L.
Ding, Z. Wu, S.H. Phan. Univ. of Michigan.
10:15 50.7
R-Spondin2 Is Upregulated in Idiopathic
Pulmonary Fibrosis and Affects Fibroblasts Behavior. A.
Munguia, C. Becerril, C. Mendoza, Y. Balderas, R. Ramirez,
J. Melendez, A. Pardo, M. Selman. Biol. Sci., Natl. Inst. of
Resp. Dis., Fac. of Sci. and Natl. Inst. of Genomic Med.,
UNAM, Mexico City.
10:30 50.8
TMPRSS4: A Novel Serine Protease Involved
in IPF Development? A.M. Valero, J. Cisneros, R. Ramírez, M.
Gaxiola, C. Becerril, A. Pardo, M. Selman. Fac. of Sci, Natl.
Autonomous Univ. of Mexico and INER, Mexico City.
10:45 50.9
Advancement in the Diagnosis and Treatment
of Granulomatous/Lymphocytic Interstitial Lung Disease. B.R.
Hoffmann, A. Vallejos, A.S. Greene, J.M. Routes. Med. Col.
of Wisconsin and Children’s Hosp. of Wisconsin.
11:00 50.10
Absence of Mast Cells in an Experimental
Model of Pulmonary and Cardiac Fibrosis, the CUX-1 Mice.
N.A. Reddy, F. Raza, A. Said, S. Livingston, D. Jacobsen,
D. Kearns, R. Baybutt, G. Van Den Heuvel, A. Molteni, S.
Hamidpour. Univ. of Missouri Kansas City, Wheaton Col., IL
and Western Michigan Univ.
SATURDAYPATHOLOGY
51.
IMAGING PATHOLOGY: HOW TO CATCH LIGHT
IN A BOTTLE
52.
Minisymposium
XVITH ANNUAL WORKSHOP ON GRADUATE
EDUCATION IN PATHOLOGY: INTEGRATING
CLINICAL AND ANATOMIC PATHOLOGY
Workshop
Chaired: R. Levenson
(Sponsored by: the ASIP Education Committee and the
Association of Pathology Chairs )
Cochaired: D. Kaufman
Digital and Computational Pathology
Sat. 11:45 am—San Diego Marriott Marquis & Marina Hotel,
Temecula
Imaging, Immunohistochemistry and Microscopy
Chaired: D. Karcher
8:30
Introduction.
8:35 51.1
Assessment of Autofluorescent Signatures
in Multiple Tissue Types with Novel Excitation-Scanning
Hyperspectral Imaging. P.F. Favreau, J.A. Deal, D.A. Weber,
T.C. Rich, S.J. Leavesley. Univ. of South Alabama.
8:50 51.2
Potential of Hyperspectral Imaging for LabelFree Tissue and Pathology Classification. J.A. Deal, P. Favreau,
D. Weber, T. Rich, S. Leavesley. Univ. of South Alabama.
9:05 51.3
MUSE: A New, Fast, Simple Microscopy
Method for Slide-Free Histology and Surface Topography.
R.M. Levenson, F. Fereidouni. Univ. of California Davis Med.
Ctr., Sacramento.
9:20 51.4
Lymphocyte Response Assay: Report on
Precision of Novel Cell Culture Test. A.E. Lynch, R. Jaffe. Hlth.
Studies Collegium, Ashburn, VA.
9:35 51.5
Monitoring Cell Death in Real-Time/TimeLapse Studies. R. Edward. BioStatus Ltd., Shepshed, U.K.
9:50 51.6
How Different Are We? Performing Formalin
Fixed Paraffin Embedded Tissue Immunohistochemistry
across Species. K.N. Gibson-Corley, G. Ofori-Amanfo, M.R.
Leidinger, A.M. Lambertz. Univ. of Iowa.
10:05 51.7
FLIM-FRET Imaging of Ligand-Receptor
Binding in Tumor Cells In Vitro and In Vivo. M.M. Barroso, A.
Rudkouskaya, S. Patel, N. Sinsuebphon, X. Intes. Albany
Med. Col. and Rensselaer Polytech Inst.
10:20 51.8
Digital Determination of Chemotherapeutic
Drug-Induced Damage Sites in Single DNA Molecules Using
Nanofluidic Channels. D.G. Kaufman, P.D. Chastain, S.A.
Soper. Univ. of North Carolina at Chapel Hill and William Carey
Univ. Col. of Osteo. Med., MS.
10:35 51.9
Deterministic Transfection and Genetic
Manipulation of Organotypic Brain Slice Cultures for Ex Vivo
Imaging. P.E. Gygli, S. Byers, N. Higuita-Castro, C. Czeisler,
D. Gallego-Perez, J.J. Otero. The Ohio State Univ. and
Kenyon Col., OH.
10:50
Discussion.
Visit the Exhibits
April 3–April 5
Exhibit Hours
Sunday–Tuesday
9:00 AM–4:00 PM
Cochaired: M. Willis
Education
Pathobiology Education
11:45Introduction. D. Karcher. The George Washington Univ.
11:50 The Graduate Program at UCSD. S. Gonias. UCSD
12:00 The Graduate Program at the University of Pittsburgh.
G.K. Michalopoulos. Univ. of Pittsburgh
12:10 The Graduate Program at UNC. J. Homeister. Univ. of
North Carolina at Chapel Hill
12:30Discussion.
53.
HIGHLIGHTS: GRADUATE STUDENT
RESEARCH IN PATHOLOGY
Poster Discussion
(Sponsored by: ASIP Committee for Career Development
and Diversity)
Chaired: T.A. Reaves
Cochaired: B. Woolbright
1:30
Welcome and Introduction.
1:35
Oral Presentations
1:45
Microvascular Endothelial Cells Can Exhibit Autophagy
In Vivo: Role in Neutrophil Transendothelial Cell
Migration? C.M. Pickworth, R. Beal, N. Reglero, L.
Lintermans, B. Colom, M-B. Voisin, M. Golding, S.
Nourshargh. Barts and The London Sch. of Med. and
Dent., Queen Mary Univ. of London. (165.8)
Role of Sumoylation in Aldehyde Dehydrogenase 2
Function during Alcoholic Liver Disease. C. Cossu, K.
Ramani, Y. Spissu, A. Floris, M.L. Tomasi. CedarsSinai Med. Ctr., Univ. of Sassari and Univ. of Cagliari,
Italy. (516.10)
Activation of TRPVv1 by 12(S)-HpETE and 20-HETE
Releases CGRP and Protects the Heart against the
Cardiac Dysfunction Caused by LPS. J. Chen, A.J.P.
Hamers, M. Finsterbusch, C. Thiemermann, A.
Ahluwalia. Barts and The London Sch. of Med. and
Dent., Queen Mary Univ. of London. (306.4)
1:55
2:05
25
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PATHOLOGYSATURDAY
2:05
Poster Presentations
P2
Foxi3: A Sly Regulator of Bone Development, Promotes
Prostate Cancer. A. Mukherjee. Troy Univ. (698.20)
Mechanisms Underlying the Induction of a Profibrotic
Epithelial Phenotype during Renal Fibrosis. J. Folke
Bialik, M. Rozycki, P. Speight, Z.M. Miranda, S.G.
Szeto, D.A. Yuen, Q. Dan, K. Szászi, S.F. Pedersen,
A. Kapus. St. Michael’s Hosp., Toronto, Univ. of
Copenhagen and Univ. of Toronto. (445.6)
Inflammation as a Contributor to Ingestive and Vocal
Dysfunction in a PINK1 Knockout Rat Model of
Parkinson Disease. K.M. Yang, H.N. Mulholland, M.P.
Kurup, M.R. Ciucci. Univ. of Wisconsin-Madison.
(1179.2)
A Novel Bioinspired Microfluidic Assay for Investigation
of the Role of Protein Kinase C-Delta in Human
Neutrophil-Endothelium Interaction during Acute
Inflammation. F. Soroush, Y. Tang, P. Pandian,
L.E. Kilpatrick, M.F. Kiani. Temple Univ. and CFD
Research Corp., Huntsville, AL. (1177.3)
Cell-Type Specific Mechanisms Regulate Rhythmic
Leukocyte Migration to Tissues. W. He, K. Kraus,
D. Druzd, A. de Juan, L. Ince, C-S. Chen, C.
Scheiermann. Ludwig Maximilians Univ., Munich.
(165.11)
OxLDL Exerts a Biphasic Effect on Endothelial
Function: A Role for Oxidised Lipids in Angiogenesis
and Inflammation. M. Olding, M.R. Ardern-Jones, E.
Healy, T.M. Millar. Univ. of Southampton. (165.9)
P4
P6
P8
P10
P12
2:55
Oral Presentations
3:05
CD36-Myeloperoxidase Connection and the Activation
of Intestinal Fibroblasts. M. Anderson-Thomas, A.
Nillas, T.A. Reaves. Med. Univ. of South Carolina.
(922.1)
Intercellular Adhesion Molecule 1 Regulates Left
Ventricular
Leukocyte
Recruitment,
Cardiac
Remodeling and Function in Pressure OverloadInduced Heart Failure. A.M. Salvador, T. Nevers, M.
Aronovitz, B. Wang, I. Jaffe, R. Blanton, P. Alcaide.
Tufts Med. Ctr. (306.6)
Influence of PI3K and MAPK Pathway Mutations on
Response to Mono and Dual Treatment with Targeted
Kinase Inhibitors. R.S. McNeill, D.A. Canoutas, R.E.
Bash, R.S. Schmid, B.H. Constance, G.L. Johnson,
C.R. Miller. Univ. of North Carolina at Chapel Hill.
(515.1)
3:05
3:05
3:05
Poster Presentations
P1
Expression Analysis of Arpin, a Novel Arp2/3 Inhibitor,
in Endothelial and Epithelial Cells under Basal and
Inflammatory Conditions. S.D. Chanez Paredes,
J. Garcia Cordero, H. Vargas Robles, L. Cedillo
Barron, M. Schnoor. CINVESTAV, Mexico City.
(1180.2)
Nicotine Promotes Cholangiocarcinoma Growth in
Xenograft Mice. A. O’Brien, C. Hall, L. Ehrlich, T.
White, T. Lairmore, D.E. Dostal, S. Glaser. Texas
A&M Hlth. Sci. Ctr., Baylor Scott & White Healthcare
and Central Texas Veterans Hlth. Care Syst., Temple.
(56.5)
P3
26
P5
Cathepsin Localization and Activity on the Intestinal
Epithelial Barrier of Rats following Hemorrhagic
Shock and Reperfusion. A.S. Courelli, F. DeLano,
G.W. Schmid-Schonbein. UCSD. (920.2)
P7
Role of Cox Pathway in Human Monocytes and
Monocyte-Derived Dendritic Cells Infected by
Trypanosoma cruzi. S.C.H. Lonien, R.C. de Freitas,
H.T. Suzukawa, F.F. dos Santos, M.I. Lovo-Martins,
G.F. Silveira, P.F. Wowk, J. Bordignon, P. PingeFilho. State Univ. of Londrina and Oswaldo Cruz
Fndn., Curitiba, Brazil. (925.20)
P9FoxP3+ T-Cells and PD-L1 Highlight ImmuneSuppressive Profiles in Vulvar Squamous Cell
Carcinoma. E.R. Holthoff, T. Kelly, C.M. Quick, S.R.
Post. Univ. of Arkansas for Med. Sci. (439.10)
P11 Pharmacological Inhibition of p38/MAPK Improves
Cardiac Function in Cardiac-Specific Bag3-P209L
Transgenic Mice. S.C. Eaton, S. Takayama, T.N.
Sidorova, K.T. Murray, M.S. Willis. Univ. of North
Carolina at Chapel Hill, Boston Univ. and Vanderbilt
Univ. (306.5)
3:50
ASIP Young Scientist Leadership Award Lecture:
Approaching Amyotrophic Lateral Sclerosis from
Cellular, System and Technological Angles. C.
Kolarcik. Univ. of Pittsburgh.
3:50
Concluding Remarks.
54.
ASIP YOUNG SCIENTIST LEADERSHIP
AWARD LECTURE
Award Lecture
Neurobiology
Neuropathology
3:35
55.
ASIP Young Scientist Leadership Award Lecture:
Approaching Amyotrophic Lateral Sclerosis from
Cellular, System and Technological Angles. C.
Kolarcik. Univ. of Pittsburgh.
MOLECULAR AND CELLULAR BASIS
OF DISEASE: FROM PREVENTION TO
CANCER METASTASIS
Symposium
(Sponsored by: the ASIP Tumor Microenvironment &
Metastasis Scientific Interest Group )
Chaired: P. Dasqupta
Cochaired: A. Maitra
Cancer Biology
Breast Cancer
Tumor Microenvironment and Metastasis
2:00Introduction. M.E. Sobel. ASIP.
2:05
ASIP Gold-Headed Cane Award Lecture: Biology
and Therapy of Cancer Metastasis. I. Fidler. Univ. of
Texas MD Anderson Cancer Ctr.
SATURDAYPATHOLOGY
3:00
3:45
56.
Origin and Evolution of Metastatic Traits in Breast
Cancer. Y. Kang. Princeton Univ.
Getting across the Endothelial Gate: Mechanisms
and Opportunities to Prevent Metastasis. L. IruelaArispe. UCLA.
CELL-MOLECULE CIRCUITRY OF LIVER
INJURY AND REGENERATION
Minisymposium
2:00 pm—San Diego Convention Center, Room 4
Chaired: K. Nejak-Bowen
Cochaired: H. Francis
Liver Pathobiology
2:00 56.1
Hepatic Stellate Cells Play an Essential Role in
Acetaminophen-Induced Hepatocyte Injury with or without Prior
Endotoxemia. R. Rani, A. Tandon, S. Kumar, C.R. Gandhi.
Univ. of Cincinnati and Cincinnati Children’s Hosp. Med. Ctr.
2:15 56.2
Cross-Talk among Kupffer Cells and Hepatic
Stellate Cells Is Critical for Kupffer Cell Activation during Liver
Injury. K. Roth, B. Copple, R. Albee. Michigan State Univ.
2:30 56.3
Epigenetic Silencing of MicroRNA-34a in
Human Cholangiocarcinoma Cells via DNA Methylation and
EZH2: Impact on Regulation of Notch Pathway. H. Kwon,
K. Song, C. Han, J. Zhang, N. Ungerleider, L. Yao, T. Wu.
Tulane Univ.
2:45 56.4
A Balancing Act: Role of HNF4α and β-Catenin
in Hepatobiliary Development and Cholangiocarcinoma
Pathogenesis. C. Walesky, W. Goessling. Harvard Med. Sch.,
Brigham and Women’s Hosp.
3:00 56.5
Nicotine
Promotes
Cholangiocarcinoma
Growth in Xenograft Mice. A. O’Brien, C. Hall, L. Ehrlich, T.
White, T. Lairmore, D.E. Dostal, S. Glaser. Texas A&M Hlth.
Sci. Ctr., Baylor Scott & White Healthcare and Central Texas
Veterans Hlth. Care Syst., Temple.
3:15 56.6
Stem Cell-Based Biliary Organoids and
Gallbladder-Like Structures for Disease Modeling of Primary
Sclerosing Cholangitis and Alagille Syndrome. D. Contreras,
J. Ignatius Irudayam, A.W. Annamalai, A. Klein, S.W.
French, V. Arumugaswami. Bd. of Governors Regen. Med.,
Inst., Cedars Sinai Med. Ctr. and UCLA.
3:30 56.7
The Secretin Receptor Antagonist (SCT 5-27)
Reduces Biliary Hyperplasia and Liver Fibrosis in an Animal
Model of Primary Sclerosing Cholangitis. S. Glaser, F. Meng,
N. Wu, J. Venter, K. Kyritsi, G. Alpini. Texas A&M Hlth. Sci.
Ctr., Central Texas Veterans Hlth. Care Syst. and Baylor Scott
& White Healthcare.
3:45 56.8
Cholangiocyte Regeneration and Liver Repair
Are Impaired in HDC-/- Mice following 70% Partial Hepatectomy
via Dysregulated Notch Signaling. H. Francis, L. Hargrove, F.
Meng, L. Kennedy, S. DeMorrow, G. Alpini. Central Texas
Veterans Hlth. Care Syst., Baylor Scott & White Hlth. and
Texas A&M Hlth. Sci. Ctr., Temple.
4:00 56.9
Epidermal Growth Factor Receptor Signaling:
A Double-Edged Sword in Acetaminophen-Induced Liver Injury
and Regeneration. B. Bhushan, P. Borude, M.W. Manley, H.
Chavan, Y. Xie, K. Du, M. McGill, M. Lebofsky, H. Jaeschke,
P. Kasturi, U. Apte. Univ. of Kansas Med. Ctr.
4:15 56.10
Dysregulation of miRNA Regulatory Networks
by Chronic Ethanol Consumption Impairs Liver Regeneration.
A. Parrish, E. Juskeviciute, J.B. Hoek, R. Vadigepalli.
Thomas Jefferson Univ.
4:30 56.11
Cell-Specific Wnts Regulate Liver Zonation
and Regeneration. M. Preziosi, J. Yang, H. Okabe, C. Diegel,
B. Williams, S. Monga. Univ. of Pittsburgh and Van Andel Inst.,
Grand Rapids, MI.
4:45 56.12
Deletion of Estrogen Receptor Alpha in Rats
Speeds Up Liver Regeneration after CCl4-Induced Liver Injury.
S. McGreal, M.A.K. Rumi, M. Soares, U. Apte. Univ. of Kansas
Med. Ctr.
57.
TISSUE INFLAMMATION AND
LEUKOCYTE TRAFFICKING
Minisymposium
Chaired: D. McCay
Cochaired: R. Jones
Inflammation/Immunity
Inflammation
Vascular Biology
2:00 57.1
Extracts of the Tapeworm, Hymenolepis
diminuta, Recruit CCR2+PDL1+ Myeloid Cells with the Capacity
to Inhibit Dextran Sodium Sulphate-Induced Colitis. F. Lopes,
J.L. Reyes, G. Leung, N. Mancini, A. Wang, D. McKay. Univ.
of Calgary, Canada.
2:15 57.2
Microbiota-Derived Tryptophan Metabolites
Activate Aryl Hydrocarbon Receptor and Induce IL-10
Receptor Expression in Intestinal Epithelia. E.E. Alexeev, J.M.
Lanis, K.D. Schwisow, D.J. Kominsky, S.P. Colgan. Univ. of
Colorado Anschutz Med. Campus and Montana State Univ.
2:30 57.3
Cell Differentiation in the Murine Intestine
Requires NADPH Oxidase 1. T. Darby, R. Jones. Emory Univ.
2:45 57.4
Hypoxia-Regulated Autophagic Pathways
Mediate Epithelial Defense during Mucosal Inflammation. D.
Kitzenberg, B. Saeedi, C. Kelly, K. Schwisow, E. Campbell,
J. Lanis, V. Curtis, L. Glover. Univ. of Colorado AMC, Aurora
and Emory Univ. Sch. of Med.
3:00 57.5
Markers of Hypoxia and Correlation with
Disease Severity in Inflammatory Bowel Disease. K.D.
Schwisow, S. Colson, M. Gerich, M. Lovell, A. Allshouse, A.
Yeckes, B. Kessler, S. Keely, E. Hoffenberg, E. de Zoeten, S.
Colgan. Univ. of Colorado, Children’s Hosp. Colorado, Univ. of
Colorado Hosp. and Colorado Sch. of Publ. Hlth., Aurora.
3:15 57.6
Entamoeba
histolytica
Stimulates
the
Release of the Alarmin Molecule HMGB1 upon Contact with
Macrophages. S. Begum, J. St-Pierre, F. Moreau, K. Chadee.
Univ. of Calgary, Canada.
3:30 57.7
Endotoxin-Stimulated Hepatic Stellate Cells
Increase Suppressive Potential of Regulatory T Cells via IDOMediated AhR Activation: Therapeutic Implications. S. Kumar,
A. Dangi, C.R. Gandhi. Univ. of Cincinnati and Cincinnati
Children’s Hosp. Med. Ctr.
3:45 57.8
Differential Regulation of Macrophage Glucose
Metabolism by M-CSF and GM-CSF: Implications for 18F-FDG
PET Imaging of Inflammation. S. Tavakoli, J.D. Short, K.
Downs, N. Huynh Nga, R. Asmis. Univ. of Texas Hlth. Sci. Ctr.
at San Antonio.
27
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A
T
PATHOLOGY/PHARMACOLOGYSATURDAY
4:00 57.9
CD43 Contributes to Mouse Th17 Cell
Adhesion to Intercellular Adhesion Molecule-1. F.E. Velazquez,
A. Salvador, T. Nevers, P. Alcaide. Tufts Sackler Grad. Sch.
and Tufts Med. Ctr.
4:15 57.10
FPR1 and Activation of Intestinal Fibroblasts.
T.A. Reaves, M. Anderson-Thomas, A. Nillas, M. Lecher.
Med. Univ. of South Carolina and Col. of Charleston.
58.
59.
ASIP OUTSTANDING INVESTIGATOR
AWARD LECTURE
Award Lecture
Cancer Biology
Neoplasia
ASIP TRAINEE AND STUDENT
WELCOME RECEPTION
5:00
Special Session
Foyer outside Rooms 1–5
ASIP Outstanding Investigator Award Lecture: Making
Progress against Pancreatic Cancer: Where the
Rubber Hits the Road. A. Maitra. MD Anderson
Cancer Ctr.
Pharmacology
60.
SECURING NIH INTRAMURAL
FELLOWSHIPS TO ENHANCE YOUR
PHARMACOLOGY TRAINING
61.
Symposium
Symposium
(Sponsored by: The Division for Pharmacology Education)
(Cosponsored by: all Divisons)
Cochaired: K. Karpa and J.P. Neiswinger
Pharmacology Education
Cochaired: J. Clark and A. Reid
Education
Education
Career Development
9:30Introduction.
9:35
Fellowship Opportunities at the NIH. A. Reid. NIMH, NIH.
10:00 NIMH: Opportunities for the Investigation and Treatment
of Mental Illnesses Through Basic and Clinical
Research. J. Clark. NIMH, NIH.
10:25 NIAID’s Global Health Research Challenge: Emerging,
Persisting and Preventing Infectious Diseases. W.
Fibison. NIAID, NIH.
10:50 An Overview of the NINDS Intramural Research
Program from Basic to Clinical Neurosciences. K.
Roche. NINDS, NIH.
11:15 NIDCD Research Training in the Hearing and
Communication Sciences. E. Monzack. NIDCD, NIH.
Career Development
12:00 The What and Whys of IDPs for NIH-Supported
Trainees. N. Desmond. NIMH, NIH.
12:30 Using Available Tools to Facilitate IDP Development. C.
Fuhrmann. Univ. of Massachusetts Med. Sch.
1:00
The Reality of IDP Implementation. P. S. Clifford. Univ.
of Illinois at Chicago.
1:30 How an IDP Jump-Started My Career. A.
Klementowicz. UCSF.
2:00
Panel Discussion.
62.
GRADUATE STUDENT POSTDOCTORAL COLLOQUIUM
Colloquium
(Sponsored by: The ASPET Mentoring and Career
Development Committee )
Sat. 2:45 pm—San Diego Marriott Marquis & Marina Hotel,
San Diego Ballroom B
EB 2016?
28
TEACHING INSTITUTE: DEVELOPING MENTEES
USING IDPS
Chaired: L. Wecker
Career Development
Education
2:45
Mentoring Your Mentor: Key Skills for Effective Mentoring
Relationships with Shared Responsibility. R. McGee.
Northwestern Univ. Feinberg Sch. of Med.
SATURDAYPHARMACOLOGY/PHYSIOLOGY
63.
ASPET BUSINESS MEETING AND
AWARDS PRESENTATION
64.
ASPET-PHRMA FOUNDATION OPENING AND
AWARDS RECEPTION
Business Meeting
Special Event
Sat. 7:30 pm—San Diego Convention Center, East
Mezzanine and Terrace
Hear updates on Society activities and initiatives. Join us
in recognizing excellence in pharmacology as we present the
ASPET 2016 Scientific Achievement Awards, Travel Awards, and
PhRMA Foundation Awards.
The opening reception immediately follows the conclusion
of the business meeting. ASPET members and pharmacology
attendees are welcome to join us as we celebrate our awardees
and the 50th Anniversary of the PhRMA Foundation.
Physiology
65.
KEEP YOUR EYE ON THE ION. REFRESHER
COURSE ON IONIC HOMEOSTASIS AND
SYSTEMS PHYSIOLOGY
MICROCIRCULATION: PRESIDENT’S
SYMPOSIUM: BLOOD CELLMICROVESSEL INTERACTIONS
Symposium
Symposium
(Sponsored by: APS Education Committee)
(Sponsored by: The Microcirculatory Society)
Chaired: D.W. Rodenbaugh and K. Scrogin
Chaired: R.E. Rumbaut
Ion Transport
Education
Hypertension
8:00
Regulation of Sodium Homeostasis and Hypertension.
J. Osborn. Univ. of Minnesota, Minneapolis.
9:00 Regulation of Potassium Homeostasis and Renal
Disease. B. Palmer. Univ. of Texas Southwestern
Med. Ctr.
10:00 Acid Base Disturbances and Regulation of Potassium.
L. Hamm. Tulane Univ. Sch. of Med.
11:00 Cardiac Ischemia: Ionic Currents and the ECG. R.
Klabunde. Marian Univ. Col. of Osteo. Med.
66.
67.
PRE-EB MEETING OF THE EPITHELIAL
TRANSPORT GROUP AND YOUNG
INVESTIGATORS SYMPOSIUM
9:30
9:35
Chair’s introduction. R. Rumbaut. Baylor Col. of Med.
CD47 and Its Expanding Role in Innate and Adaptive
Immune Responses. F. Lucinskas. Brigham and
Women’s Hosp., Harvard Med. Sch.
10:00 Integrin Activation in Rolling Neutrophils. K. Ley. La
Jolla Inst. for Allergy and Immunol.
10:25 Contributions of Microvascular Inflammation to Wound
Healing. A.R. Burns. Univ. of Houston.
10:50 In Vivo Imaging of Infection-Induced Cogulopathy in
the Microcirculation. C.N. Jenne, R.P. Davis, B.
McDonald. Univ. of Calgary, Canada and Univ. of
British Columbia. (722.11)
11:10 Reduced Endothelial Basal Nitric Oxide Induces
Leukocyte
Adhesion
through
Src-Dependent
Phosphorylation of Constitutive Intercellular Adhesion
Molecule-1. B. Lucke-Wold, A. Logsdon, X. Li, S.
Xu, X. Lichong, C. Siedlecki, J. Huber, C. Rosen, P.
He. West Virginia Univ. Sch. of Med. and Penn State
Col. of Med. (723.11)
Special Session
(Sponsored by: APS Epithelial Transport Group)
Chaired: M. Levi
68.
THIRD ANNUAL APS PHYSIOLOGICAL
GENOMICS GROUP CONFERENCE
Special Session
(Sponsored by: APS Physiological Genomics Group)
29
S
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T
PHYSIOLOGYSATURDAY
69.
ADVANCED MICROSCOPY TECHNIQUES FOR
THE STUDY OF PHYSIOLOGY
72.
WATER AND ELECTROLYTE HOMEOSTASIS
SECTION TRAINEE AWARD FINALISTS
SESSION AND DATA DIURESIS
Workshop
1:00
1:40
2:20
70.
Award Session
Chaired: G.R. Kolar and G. Yosten
Supported by Data Sciences International and Juan
Carlos Romero Fund
Practical Application of Super Resolution Microscopy. P.
Pellett. GE Healthcare.
Correlative Light and Electron Microscopy. E. Wright.
Emory Univ.
Confocal Intravital Microscopy. S. Nourshargh. William
Harvey Res. Inst.
HAVING TROUBLE WITH YOUR IACUC?
(Sponsored by: APS Water and Electrolyte
Homeostasis Section)
Chaired: D. Ho, J. Reckelhoff and P. O’Connor
Trainee Awards Finalists Competition
Chaired: Dao Ho and Jane Reckelhoff.
Symposium
(Sponsored by: APS Animal Care and
Experimentation Committee)
Predoctoral Award Finalist Presentations
2:15
Chaired: J. Henegar
Science Policy
1:00
1:30
2:00
2:30
71.
What All PIs Should Know About their IACUC. J.R.
Henegar. Univ. of Missouri.
Balancing Institutional Risk and Compliance. J.
Haywood. Michigan State Univ.
How Offensive Is the Offense? And Other IACUC
Debates. A. Comuzzie. Texas Biomed. Res. Inst.
Ideas for Improving Animal Research Regulaotory
Burden. B. Hansen. Univ. of South Florida.
MICROCIRCULATION: SIGNAL INTEGRATION
AND MICROCIRCULATORY BLOOD FLOW
CONTROL: MAKING PARTS WHOLE USING A
NETWORK APPROACH
Symposium
Chaired: D.N. Jackson and I. Lamb
1:00 Chair’s
introduction.
D. Jackson.
Univ.
of
Western Ontario.
1:15 Distinct Modes of Excitation-Contraction Coupling
Encode Arteries with Spatial Properties. D. Welsh.
Univ. of Western Ontario.
1:45
Potassium Sensing by Capillary Kir Channels Regulates
Cerebral Blood Flow. T. Longden. Univ. of Vermont.
2:15 Propagation
of
Capillary-Initiated
Conducted
Vasodilation in Skeletal Muscle – a Novel Paracrine
Signaling Pathway. N.M. Novielli, C.L. Murrant. Univ.
of Guelph, Canada. (945.17)
2:30
Distinct EC Coupling Mechanism Drives Spatial Control
of Vascular Tone in Cerebral Arteries. A. Zechariah,
B.O. Hald, N.G. Mazumdar, D.G. Welsh. Univ. of
Western Ontario and Univ. of Copenhagen. (945.10)
2:45
Chair’s Closing Remarks and Open Forum Q&A. D.
Jackson. Univ. of Western Ontario.
30
2:30
2:45
Chronic Flutamide Treatment Alters Intrarenal Renin
Angiotensin System Expression in Intrauterine
Growth Restricted Female Rats. J.H. Dasinger, S.
Intapad, B.R. Rudsenske, B.T. Alexander. Univ. of
Mississippi Med. Ctr. (1214.5)
Flow-Induced Activation of NO Production Is Calciumand HDAC1-Dependent in Inner Medullary Collecting
Duct Cells. R.S. Sedaka, K.A. Hyndman, J.S.
Pollock. Univ. of Alabama at Birmingham. (964.17)
A high Fat Diet Increases Blood Pressure and Leads
to a Renal Proinflammatory Immune Cell Profile in
Female Dahl Salt-Sensitive Rats. L. Taylor, J. Musall,
B. Baban, E.J. Belin de Chantemele, J. Sullivan.
Georgia Regents Univ. (964.5)
Postdoctoral Award Finalists Presentations
(Sponsored by: Juan Carlos Romero Fund)
3:00
Estradiol Facilitates a More Rapid Natriuretic Response
to a High Salt Diet in Female Rats. E.Y. Gohar, D.M.
3:15 RhoBTB1, a Novel PPARγ Target Gene Regulates
Vascular Function. M. Mukohda, S-R.C. Ibeawuchi,
C. Hu, F.W. Quelle, C.D. Sigmund. Univ. of Iowa and
California Inst. for Biomed. Res., La Jolla. (964.14)
3:30 Mycophenolate Mofetil Attenuates Hypertension
in an Experimental Model of Systemic Lupus
Erythematosus. E. Taylor, A. Strawder, M. Ryan.
Univ. of Mississippi Med. Ctr. (964.4)
3:45
Mingle with Open Bar.
Enhance Your EB Experience.
Download the App!
The latest scientific sessions
and Event information at your
fingertips.
Download at http://m.coreapps.com/eb2016 or scan the QR Code.
SATURDAYPHYSIOLOGY
Data Diuresis Brief Presentations
Supported by: Data Sciences International
Chaired: P. O’Connor and A. Polichnowski
4:15
4:20
4:25
4:30
4:35
4:40
4:45
4:50
73.
Blood Pressure Regulation under Low K+ Intake
Depends on the H,K-ATPase Type 2. G. Crambert, A.
Salhi, C. Lamouroux. Cordeliers Res. Ctr., INSERM
U1138, CNRS, Paris. (1216.15)
The Predominant Role of Kidney in Sex Difference in
Ang II-Induced Hypertension. L. Wang, R. Chen, J.
Zhang, S. Rong, S. Wang, J. Wei, K-P. Yip, R. Liu.
Univ. of South Florida and Hannover Med. Sch.,
Germany. (963.4)
Effect of a Dietary and Exercise Intervention during
Pregnancy and Lactation on White Adipose Tissue
Gene Profiles and Adiposity with Maternal Obesity. M.
Symonds, I. Bloor, F. Galvez, E. Domfeh, B. Maicas,
L. Poston, P. Taylor. Univ. of Nottingham, Fac. of
Med., Granada and King’s Col. London. (1214.3)
High Salt Activates Dendritic Cells to Promote
Hypertension. J.D. Foss, N. Barbaro, L. Xiao, S.
Dikalov, D.G. Harrison, A. Kirabo. Vanderbilt Univ.
(1216.5)
Preserved Survival of Renal Tubulus-Specific Sodium
Hydrogen Exchanger Isoform 3 Knockout Mice in
Response to Sodium Restriction. S. Chavez, S.B.
Poulsen, M. Soleimani, R.A. Fenton, T. Rieg.
UCSD and VA San Diego Healthcare Syst., Aarhus
Univ., Denmark and Univ. of Cincinnati and VA Med.
Ctr. (962.4)
Chronic Insulin-Clamp Causes Postprandial Diuresis
in Sprague Dawley Rats. D.L. Irsik, R. Alaisami,
A.R. Washington, M.W. Brands. Georgia Regents
Univ. (962.2)
Potential Role of Renal Mineralocorticoid Receptor
Increasing the Blood Pressure Sensitivity in Female
Mice Exposed to Early Life Stress. M.O. Murphy, D.
Cohn, A.S. Loria. Univ. of Kentucky. (1213.5)
Mingle with Open Bar.
DATA NCARNATION
Theme: Clinical Correlations
3:05
3:10
3:15
3:20
Theme: Cell Signaling
3:35
3:40
3:45
3:50
4:05
4:10
Chaired: M. Santisteban and E. Lazartigues
3:00Introduction.
Dysregulation of Cardiac cAMP in Nicotine Stimulated
Sympathetic Neuronal-Myocyte Co-cultures from
Hypertensive Rats: Are Sympathetic Neurons the
Primary Driver of Autonomic Hypertension? H.E.
Larsen, K. Lefkimmiatis, D.J. Paterson. Univ. of
Oxford. (1006.7)
Macrophage-Dependent Impairment of α2 Autoreceptor
Inhibition of Ca2+ Currents in Sympathetic Neurons
Contributes to Hypertension in DOCA-Salt Rats. R.
Mui, R. Fernandes, J. Galligan. Michigan State Univ.
(757.8)
Reduced Bone Marrow Adrenergic Receptor Signaling
Modulates PVN Inflammatory Factors. N. Ahmari,
J.T. Schmidt, C.T. Martyniuk, J. Zubcevic. Univ. of
Florida. (1237.6)
Discussion and Break.
Theme: Peripheral Autonomic Function
Award Session
(Sponsored by: APS Neural Control and Autonomic
Regulation Section)
Intermittent Hypoxia Decreases Baroreflex Sensitivity
in Healthy Humans. Z.M. Scruggs, L.P. Newhouse,
M.J. Joyner, T.B. Curry, J.K. Limberg. Mayo Clin.
(753.5)
Sleep Apnea Worsens Muscle Vasoconstriction during
Central and Peripheral Chemoreceptors Stimulation
in Patients with Systolic Heart Failure. D.M.L. Lobo,
P.F. Trevizan, E. Toschi-Dias, P.A. Oliveira, R.B.
Piveta, C. Mady, E.A. Bocchi, D.R. Almeida, G.
Lorenzi-Filho, H.R. Middlekauff, C.E. Negrão. Heart
Inst., Univ. of São Paulo Med. Sch., Fed. Univ. of São
Paulo and Geffen Sch. of Med. at UCLA. (755.6)
Exaggerated Blood Pressure and Sympathetic Reactivity
in Patients with Type 2 Diabetes. J.R. Vranish, S.W.
Holwerda, D.M. Keller, P.J. Fadel. Univ. of Texas at
Arlington and Univ. of Iowa. (1004.1)
4:15
4:20
Effect of Renal Denervation and Celiac Ganglionectomy
on Mean Arterial Pressure in the Hypertensive
Schlager (BPH/2J) Mice. M.M. Gauthier, C.
Breitenstein, N. Asirvatham-Jeyaraj, J.W. Osborn.
Univ. of Minnesota, Minneapolis. (1006.13)
Possible Respiratory Modulation of Sympathetic Activity
in Rats after Sino-aortic Denervation. M.R. Amorim,
L.G. Bonagamba, G.M. Souza, D.J. Moraes, B.H.
Machado. Sch. of Med. of Ribeirão Preto, Univ. of
São Paulo. (996.4)
Selective Beneficial Effects of Chronic Vagal Nerve
Stimulation on Vascular Function in Stroke-Prone
Spontaneously Hypertensive Rats on High-Salt Diet.
E.E. Meyers, M.W. Chapleau, K. Rahmouni, H.M.
Stauss. Univ. of Iowa and VA Med. Ctr. (1237.7)
31
S
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PHYSIOLOGYSATURDAY
Theme: Novel Methodologies
4:35
4:40
4:45
4:50
74.
Effects of Essential Oil on Fear Memory and the
Immune Response: A Potential Alternative Therapy
for Post-traumatic Stress Disorder. C. Moshfegh,
A.P. Swiercz, L. Hopkins, P.J. Marvar. George
An Optogenetic Test for the Functional Specificity of
Bulbospinal Sympathoexcitatory Neurons. N.H.
Pracejus, D.G.S. Farmer, R.M. McAllen. The Florey
Inst. of Neurosci. and Ment. Hlth., Parkville, Australia.
(1233.7)
Angiotensin Type 1a Receptors within the Paraventricular
Nucleus of Hypothalamus Regulate Cardiovascular
and Behavioral Responsiveness to Psychological
Stress. L. Wang, A.D. de Kloet, J.A. Smith, H. Hiller,
C. Sumners, M.K. Raizada, E.G. Krause. Univ. of
Florida. (1238.4)
Discussion and Wrap-up.
SETTING THE RECORD STRAIGHT FOR
SCIENCE: HOW TO WRITE TO LOCAL AND
NATIONAL NEWS OUTLETS
Symposium
76.
Symposium
Chaired: J. Breslin
3:30
3:30
3:30
3:30
3:30
3:30
(Sponsored by: APS Communications Committee)
Sat. 3:00 pm—San Diego Convention Center, Room 25C
75.
3:15
3:45
4:15
4:45
32
ADVANCES IN MICROVASCULAR
PERMEABILITY/GLYCOCALYX
Chaired: B. Goodman
PHYSIOLOGY IN PERSPECTIVE: THE WALTER
B. CANNON MEMORIAL AWARD LECTURE
Science Policy
Lecture
Panel Discussion. B. Yates and M. Aguilera. Univ. of
Pittsburgh and Scripps Inst. of Oceanography, UCSD.
NOVEL METHODS TO PERTURB GENES FOR
PHYSIOLOGICAL EXAMINATION
77.
Chair’s introduction. J. Breslin. Univ. of South Florida.
Interactive Roles of ROS, NO, and RNS in the Regulation
of Microvessel Permeability. P. He. Penn State Univ.
HS-FGF2-FGFR1 Signaling Contributes to Pulmonary
Endothelial Glycocalyx Reconstitution. E.P. Schmidt,
Y. Yang, M. Suflita, F. Zhang, K. Dailey, S. Haeger,
J. Ford, R. Linhardt. Univ. of Colorado, Aurora and
Rensselaer Polytech Inst. (950.4)
Hydrogen Sulfide Metabolism Regulates Endothelial
Permeability. S. Yuan, S. Pardue, A.W. Orr, C.G.
Kevil. LSU Hlth. Sci. Ctr., Shreveport. (950.12)
Lymphatic Vascular Integrity Is Disrupted in a Mouse
Model of Diabetes: Dual Regulation by Nitric Oxide.
J.P. Scallan, M.A. Hill, M.J. Davis. Univ. of South
Florida and Univ. of Missouri-Columbia. (950.9)
Functional Significance of eNOS Traffic. W. Duran.
Rutgers Univ.
Sat. 5:30 pm—San Diego Convention Center, Ballroom 20A
Workshop
MICROCIRCULATORY SOCIETY
POSTER DISCUSSION
3:15 pm—San Diego Convention Center, Room 26
Special Session
Chaired: B.T. Andresen and B. Joe
Cellular Genomic Editing. D. Hockemeyer. Univ. of
Introduction to the RCAS/TVA System – A Tissue
Specific Transgene Expression System. E. Holland.
Fred Hutchinson Cancer Res. Ctr.
Choosing the Right Genome Editing Technology:
CRISPR,
TARGATT™,
or
Homologous
Recombination? R. Chen-Tsai. Applied StemCell
Inc., Menlo Park, CA.
Round Table Discussion.
78.
Muscle-Immune Cell Crosstalk in the Genesis of Insulin
Resistance. A. Klip. Hosp. for Sick Children, Toronto.
Chaired: W.L. Murfee, A. Gonzalez and J. Song
Light refreshments will be available
SUNDAY, APRIL 3
Across Societies
79.
NIH K AWARDS
Practice Lab
Seminar
Sun. 9:00 am—San Diego Convention Center,
Exhibit Hall D
NIH Grants Seminar
Career Development
This presentation, by Dr. Henry Khachaturian of NIGMS, NIH,
will focus on the NIH’s new K99/00 Pathways to Independence
Award (for postdoctoral scientists) and the K08 Mentored Clinical
Scientist Development Award (for individuals with a health
professional doctoral degree committed to a career in laboratory
or field-based research). The interactive discussion will give
attendees an opportunity to ask questions of and obtain insight
from an NIH representative.
80.
NIH FELLOWSHIP (F) AWARDS
Seminar
Sun. 1:00 pm—San Diego Convention Center,
Exhibit Hall D
NIH Grants Seminar
Career Development
This presentation, by Dr. Henry Khachaturian of NIGMS,
NIH, will focus on the NIH’s Ruth L. Kirschstein National Research
Service Awards (NRSA). The NRSA research training fellowship
(F) awards are targeted to individuals with or seeking research
doctoral degrees (Ph.D. and equivalent) and clinical doctoral
degrees (M.D. and equivalent). Among the F awards discussed
will be the F30, NRSA Individual Predoctoral MD/PhD or Other
Dual-Doctoral Degree Fellowship Award, the F31 NRSA Individual
Predoctoral Fellowship, the F31 NRSA Individual Predoctoral
Fellowship to Promote Diversity in HealthRelated Research
Award, the F32 NRSA Individual Postdoctoral Fellowship Award,
and the NRSA Individual Senior Fellowship Award. The interactive
discussion will give attendees an opportunity to ask questions
of and obtain insight from an NIH representative on these and
other awards available for pre- and postdoctoral fellows and
senior investigators.
Handouts and resource materials will be provided on-site.
81.
CAREER DEVELOPMENT WORKSHOPS
Workshop
Exhibit Hall D
9:00
Making Mistakes When Speaking: How to Handle Them.
J. Blumenthal. Montgomery Col., MD.
9:30
Nailing the Job Talk & Interview Prep. A. Green. Univ. of
9:30 Global Interview Skills: A Practice Workshop for
International Candidates. D. Behrens. Univ. of
10:00 Responsible Conduct of Research Part 1: Historical
Perspectives: Past Controversies, Successes, and
Present Challenges. S. Sodeke, T. Turner. Tuskegee
Univ., Jackson State Univ.
10:30 Making the Case for Graduate School. H. Adams. H.G.
11:00 Job Hunting in Biotech Part 1: Finding & Applying for
11:00 Ten Ways to Get Lucky in the Job Search. P. Clifford.
Med. Col. of Wisconsin and Marquette Univ.
11:00 Job Talk/Chalk Talk: Making the Grade. D. Behrens.
1:00 Identifying Your Options using ScienceCareers.
org, LinkedIn & More. A. Green. Univ. of
1:00
Networking with Strangers is Required for Your Future.
1:00 Responsible Conduct of Research Part 2: Best
Practices: Mentoring, Collaboration, Peer Review,
Data Management and Ownership. S. Sodeke, T.
Turner. Tuskegee Univ., Jackson State Univ.
1:30
2:30 Talking About Yourself: How to Interview Well.
N. Saul. UCSF.
2:30
Ten Tough Industrial Interview Questions (and Ten Pretty
Good Responses). J. Tringali. Tringali & Assocs. Inc.
3:30 But I Have No Skills! J. Lombardo. Med. Col. of
Wisconsin and Marquette Univ.
4:00
4:00
Developing & Writing the Doctoral Dissertation Proposal.
H. Adams. H.G. Adams & Assocs. Inc., Norfolk, VA.
Career Development
33
S
U
N
ANATOMYSUNDAY
Anatomy
82.
NEURAL STEM CELLS AND
NEOCORTICAL DEVELOPMENT
84.
Minisymposium
Plenary
Sun. 10:30 am—San Diego Convention Center, Room 9
(Cosponsored by: Developmental Dynamics)
Chaired: K. Kramer
Chaired: B. Allman
Neurobiology
8:30
9:15
83.
TISSUE GENERATION AND TRANSPLANTATION
New Insights into Neurogenesis and Migration in the
Developing Human Neocortex. A. Kriegstein. UCSF.
Generation of Functionally Distinct Projection Neurons
in the Mammalian Neocortex. U. Mueller. The Scripps
Res. Inst.
DEVELOPMENTAL BIOLOGY AWARD
HYBRID SYMPOSIUM
10:30 84.1
Tissue Engineering: Simple versus Complex
Organs. L. Sampaio. Texas Heart Inst., Houston.
11:00
Bioinspired
Matrices
Orchestrate
Stem
Cell
Engraftment through Vascular Integration. K. Healy. Univ. of
11:30 Title TBD. A. Sacco. Sanford Burnham Prebys Med.
Discovery Inst.
85.
Hybrid Symposium
Education Roundtable
(Cosponsored by: Anatomical Sciences Education)
Chaired: D. Hockemeyer
H.W. Mossman Award Lecture in Developmental Biology
featuring 2016 Young Investigator Award Recipient, Michael
Jenkins. Nicholas Mignemi is competing as a finalist in the
Postdoctoral Platform Presentation Award
10:30 83.1
Optical Tools to Assess Heart Development.
M.W. Jenkins. Case Western Reserve Univ.
11:00 83.2
Cranial Neural Crest Migration Sculpts
Endothelial Patterning in Avians with Anti-angiogenic Factors.
M.C. McKinney, P. Kulesa. Stowers Inst. for Med. Res.,
Kansas City, MO. (1029.3)
11:15 83.3
Plasminogen Is Essential to Prevent
Heterotypic Ossification following Traumatic Muscle Injury. N.
Mignemi, R.C. Ihejirika, Y. Ihejirika, C. Wallace, W. Oeslner,
C.E. Baker, J. Schoenecker. Vanderbilt Univ.
11:30 83.4
Regulating Skeletal Progenitor Cells at the
Interface between Tendon and Bone. A.E. Merrill, R. Roberts.
Univ. of So. California.
11:45 83.5
Genetic Tools for Study of the Hypothalamus
and Thyroid in Zebrafish. D. Hutcheson, Y. Xie, R. Duncan, R.
Dorsky. Univ. of Utah.
ANATOMY EDUCATION ROUNDTABLE ANATOMICAL CONTENT: WHAT TO TEACH IN A
MODERN MEDICAL CURRICULUM
Cochaired: M. Bee and V. Lyons
In this session the collective wisdom of the group will be
leveraged to determine essential content for histology, gross
anatomy and neuroscience.
Continental Breakfast will be provided, based on availability.
10:30 Anatomical Sciences in Medical Curriculum: Looking
Backward and Forward.
10:45 Group Activities: Leveraging the Collective Wisdom
of AAA.
11:45Conclusion.
86.
AXIAL ANATOMY IN PRIMATES: LOCOMOTION,
POSTURE AND EVOLUTION
Symposium
(Cosponsored by: The Anatomical Record)
Sun. 2:00 pm—San Diego Convention Center, Room 10
Chaired: C. Ward
2:00 86.1
Functional Morphology and Evolution of
the Human Trunk Musculature – Old and New Features.
N. Schilling. Friedrich Schiller Univ. Jena, Germany.
34
SUNDAYANATOMY
2:30 86.2
Determinants of Variation in Trunk Morphology
in Anthropoid Primates. C.V. Ward, E.R. Middleton. Univ.
of Missouri-Columbia.
3:00 86.3
Three-Dimensional Trunk Kinematics of
Humans and Chimpanzees: New Insights on Early Hominin
Bipedalism. N.E. Thompson, B. Demes, M.C. O’Neill. Stony
Brook Univ., Univ. of Arizona Col. of Med., Phoenix.
3:15 86.4
Functional and Behavioral Consequences
of Axial Stability in Primates and Other Mammals. M.C.
Granatosky. Duke Univ.
89.
87.
This session was funded in part by an AAA Three-Year
Research Meetings Outreach Grant
MANIPULATION OF SUBSTRATE PROPERTIES
FOR IMPROVED CONSTRUCTION OF STEM
CELL-BASED BIOMATERIALS
Minisymposium
Cochaired: E. Alsberg and D. Mills
CRANIAL SENSORY ORGANS: FROM
PLACODES TO DISEASE
Symposium
Sun. 2:00 pm—San Diego Convention Center, Room 7B
Chaired: L. Taneyhill
Neurobiology
Cell Biology
2:00 89.1
In Search of Novel Genes in Branchio-oto-renal
Spectrum Disorders. S.A. Moody. George Washington Univ.
2:30 89.2
Cranial Nerve Dysmorphogenesis in 22Q11
Deletion (DiGeorge) Syndrome. A-S. LaMantia, B.A.
Karpinski, T.M. Maynard, S.A. Moody, D. Mendelowitz, X.
Wang, A. Popratiloff, I. Zohn, N.H. Lee. George Washington
Univ. Sch. of Med. & Hlth. Sci. and Children’s Natl. Med. Ctr.
3:00 89.3
Mechanisms of Otoconia Development and
Clinical Translation. Y. Lundberg. Boys Town Natl. Res.
Hosp., Omaha.
2:00 87.1
3D-Printing and Casting of Biological
Constructs for Generating Stem Cell-Based Scaffolds. J.S.
Alexander, Y. Wang, B. Ott, M. Al-Kofahi, D.K. Mills. LSU
Hlth. Sci. Ctr. and Southwood H.S., Shreveport and Louisiana
Tech Univ.
2:30 87.2
Dynamic Stiffness Reveals New Cardiac
Phenotypes in Patient-Derived iPSCs. A.J. Engler. UCSD.
3:00 87.3
Development of Biologically Inspired 3D Printed
Biomaterial Scaffolds for Improved Stem Cell Differentiation.
L.G. Zhang. George Washington Univ.
90.
88.
4:00 90.1
Visualizing Microaggression in the Developing
Embryo: Competition between the Neural Crest and Endothelial
Cells. P. Kulesa. Stowers Inst., Kansas City, MO.
4:30 90.2
Contrast Enhanced Imaging Approaches for
Studying Vertebrate Form and Function. C.M. Holliday. Univ.
5:00 90.3
Insights into the Underwater Behavior,
Species Interactions, and Biomechanics of Baleen Whales
Using Suction-Cup Attached Video and Inertial Sensors. J.
Goldbogen, D. Cade, J. Calambokidis, A. Stimpert, A.
Friedlaender. Stanford Univ., Pacific Grove, Cascadia Res.,
Olympia, WA, Moss Landing Marine Labs., CA and Oregon
State Univ.
PROBING DEEPER: QUALITATIVE RESEARCH
IN ANATOMY EDUCATION
Symposium
Chaired: M. Hankin
2:00 88.1
Students’ Understandings of Their Ethical
Obligations to Their Cadavers after Their First Anatomy Lab:
A Qualitative Study. J. Fortunato, J. Wasserman, M. Hankin.
Oakland Univ. William Beaumont Sch. of Med. and Univ. of
Virginia Sch. of Med.
2:30 88.2
Qualitative Methods: An Overview for Anatomy
Education Research. J.A. Wasserman. Oakland Univ. William
Beaumont Univ. Sch. of Med.
3:00 88.3
Using Mixed Methods Research in Anatomy
Education: The Relevancy, Challenges, and Benefits.
E. Fillmore. Univ. of Buckingham Med. Sch., U.K.
MODERN IMAGING APPROACHES TO
STUDYING ANIMAL FORM AND FUNCTION
Symposium
Chaired: C. Holliday
35
S
U
N
ANATOMYSUNDAY
91.
CREATING STRUCTURED
MICROENVIRONMENTS FOR REGULATING
STEM CELL DIFFERENTIATION
93.
Symposium
Minisymposium
Chaired: K. Jones
Cochaired: L.G. Zhang and D. Mills
Neurobiology
4:00 91.1
Stem Cell Proliferation and Differentiation
through Capped Clay Nanotubes. S.J. Karnik, D. Robinson.
Louisiana Tech Univ.
4:30 91.2
Strategies for Inducing Spatially Defined
Stem Cell Differentiation for Tissue Engineering Applications.
E. Alsberg. Case Western Reserve Univ.
5:00 91.3
Microfluidic Systems for Stem Cell Studies. L.
Tayebi. Marquette Univ. Sch. of Dent.
92.
Cell Biology
4:00
TREM2 Dependent Microglia Functions
in TBI and Brain Inflammation. M. Carson. Univ. of
California, Riverside.
4:30 93.1
Redox Regulation of the M1/M2 Shift in
Microglia: Programming the Deleterious Phenotype. M.L.
Block. Indiana Univ. Sch. of Med.
5:00 93.2
Responses of Central Microglial Cells and
Ganglionic Macrophages to Peripheral Injury and Disease.
M. Kawaja. Queen’s Univ., Canada.
94.
APPLIED 3D PRINTING IN ANATOMICAL AND
MEDICAL EDUCATION AND RESEARCH
Chaired: J. Bertram
4:00 92.1
3D Printed Anatomical Teaching Material
– A Genuine Alternative? P.G. McMenamin. Monash
Univ., Australia.
4:30 92.2
3D Printing in Anatomical and Palaeontological
Teaching and Research. J.W. Adams. Monash Univ., Australia.
5:00 92.3
Virtual Surgical Planning and Applications
in Plastic and Craniomaxillofacial Surgery. S. Basel, J.
Matsumoto, N. Lachman, U. Bite. Mayo Clin.
AAA UNDERGRADUATE POSTER RECEPTION
Poster Discussion
Sun. 5:30 pm—San Diego Convention Center, West
Terrace Lobby
Symposium
MICROGLIA FUNCTION AND ACTIVATION IN
THE CNS
95.
MARIAN DIAMOND DOCUMENTARY
SCREENING AND RECEPTION
Special Event
Join us for a special 25-minute sneak peek of a documentary
screening of, “My Love Affair with the Brain: The Life and Science
of Marian Diamond.” Dr. Diamond is one of the founders of
modern neuroscience and has revolutionized the way we think
about how the brain ages. Light refreshments will be served
and a Q&A session with the documentary producers will follow
the screening.
36
SUNDAYBIOCHEMISTRY
96.
FASEB EXCELLENCE IN SCIENCE AWARD
Award Lecture
Sun. 8:00 am—San Diego Convention Center, Room 6B
8:00
8:05 96.1
Quorum Sensing and Its Control. B.L. Bassler.
Princeton Univ. and HHMI.
97.
ASBMB PLENARY LECTURE
Plenary
8:45
8:50 97.1
From
Protein
Folding
to
Cognition:
The Serendipitous Path of Discovery. P. Walter. UCSF, HHMI.
98.
REGULATION OF GENE EXPRESSION BY
O-GLCNAC
Symposium
Sun. 9:45 am—San Diego Convention Center, Room 1A
Chaired: C.M. Szymanski
Follow the conversation: #glyco
9:45
9:50 98.1
O-GlcNAcylation Links ChREBP to Glucose
Sensing in Liver and Pancreatic β Cells. G. Filoulaud, F.
Rayah-Benhamed, C. Guinez, B. Noblet, Y. Fardini, T. Issad,
C. Postic. Univ. Paris Descartes.
10:15
Elevated O-GlcNAcylation Levels Improve
Mitochondrial Function. E.P. Tan, R. Swerdlow, C. Slawson.
Univ. of Kansas Med. Ctr. (845.1)
10:30 98.3
Initiation and Elongation of RNA Polymerase II
Are Regulated by Multiple O-GlcNAcylation Events. B.A. Lewis.
NCI, NIH.
10:55
O-GlcNAcylation of the Human Kinome. X. Liu,
G. Han, L. Wells, L. Graves, H. Zhu, J. Neiswinger, G.W. Hart.
Johns Hopkins Univ., Univ. of Gerogia and Univ. of Illinois at
Urbana-Champaign. (845.2)
11:10
Dynamic Interactions of TATA-Box Binding
Protein with Promoters Is Regulated by O-GlcNAcylation.
S. Hardivillé, G. Han, J. Ma, P. Hu, P.S. Banerjee, G.W. Hart.
Johns Hopkins Univ. Sch. of Med. (617.1)
11:25 98.5
Mutations in O-GlcNAc Transferase Linked to
X-Linked Intellectual Disability. L. Wells. Univ. of Georgia
11:50
Discussion.
99.
NUCLEAR ARCHITECTURE AND
CHROMATIN ORGANIZATION
Symposium
Chaired: J.W. Conaway
Follow the conversation: #chromatin
9:45
9:50 99.1
The 3D Organization of the Mammalian
Genome. B. Ren. UCSD
10:15
Chromatin Extrusion Explains Key Features
of Loop and Domain Formation in Wild-Type and Engineered
Genomes. A. Sanborn, S. Rao, S-C. Huang, N. Durand, M.
Huntley, A. Jewett, I. Bochkov, D. Chinnappan, A. Cutkosky,
J. Li, K. Geeting, A. Gnirke, A. Melnikov, D. McKenna, E.
Stamenova, E. Lander, E.L. Aiden. Baylor Col. of Med.,
Stanford Univ. Sch. of Med. and Broad Inst. of MIT and Harvard.
(588.1)
10:30 99.2
Long-Range Gene Regulation in the
Context of Chromatin Domains. J. Dekker. Univ. of
Massachusetts, Worcester.
10:55
Enhancer H3K4 Methyltransferase MLL4
Controls Cell Fate Transition. K. Ge. NIDDK, NIH. (802.1)
11:10
BRD4 Is a Histone Acetyltransferase That
Evicts Nucleosomes from Chromatin. D.N. Ballachanda,
C. Case-Borden, A. Gegonne, C.H. Hsu, Q. Chen, D.
Meerzaman, A. Dey, K. Ozato, D. Singer. NCI, NIH, Bethesda
and Rockville and NICHD, NIH. (802.5)
11:25 99.3
Complex Multi-enhancer Contacts Captured
by Genome Architecture Mapping, a Novel Ligation-Free
Approach. A. Pombo, R.A. Beagrie, A. Scialdone, M.
Schueler, M. Chotalia, S.Q. Xie, D. Kraemer, I. de Santiago,
J. Fraser, J. Dostie, L. Game, N. Dillon, P.A.W. Edwards, M.
Nicodemi. Berlin Inst. for Med. Systs. Biol., Imperial Col. Sch.
of Med., U.K., Univ. of Naples Federico II, McGill Univ. and
Univ. of Cambridge.
11:50
Discussion.
100. WELCOME TO THE POST-ANTIBIOTIC ERA
Symposium
Sun. 9:45 am—San Diego Convention Center, Room 6C
Chaired: J. Prescher
Follow the conversation: #chembio
9:45
9:50 100.1
Chemical Probes for Histidine Kinase
Profiling and Inhibitor Discovery. E. Carlson. Univ. of
Minnesota, Minneapolis.
10:15
Acetylating Polymyxin Antibiotics: Clues
toward Substrate Specificity of PA3944 Gcn5-Related
N-Acetyltransferase of Unknown Function. M.L. Kuhn, L. Joe,
B. Amsler, B. Zhang, K. Majorek, R. Yen, W. Wu, G. Gassner,
T. Baird, W. Minor. San Francisco State Univ. and Univ. of
Virginia. (615.1)
37
S
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BIOCHEMISTRYSUNDAY
10:30 100.2
The Ying and Yang of Antibiotic Discovery and
Resistance. G. Wright. McMaster Univ., Canada.
10:55
Menaquinone Biosynthesis: An Antibacterial
Target? J. Matarlo. Stony Brook Univ. (612.2)
11:10
Elucidating the Molecular Basis of Protein
and Polymer Display in Pathogenic Bacteria for Novel Antivirulence Drug Development. M. Kattke, M. Sawaya, D.
Cascio, A. Duong, M. Elliot, R. Clubb. UCLA and McMaster
11:25 100.3
New Antibiotics for the Post-antibiotic Era.
S. Mobashery. Univ. of Notre Dame.
11:50
Discussion.
101. PROTEOMICS/SYSTEMS BIOLOGY FOR
HUMAN HEALTH AND MEDICINE
Symposium
Sun. 9:45 am—San Diego Convention Center, Room 6D
Chaired: L. Huang
Follow the conversation: #proteomics
9:45
9:50 101.1
Spatiotemporal Organization of Signaling:
From Plasma Membrane to Chromatin. A-C. Gingras.
Lunenfeld-Tanenbaum Res. Inst., Toronto and Univ. of Toronto.
10:15
Global Ubiquitylome Profiling for the
Identification of Drug Targets in Cancer. N.D. Udeshi, J.
Kronke, E. Fink, T. Svinkina, M. Schenone, B. Ebert, S.A.
Carr. Broad Inst. of MIT and Harvard, Univ. Hosp. of Ulm,
Germany and Brigham and Women’s Hosp. (819.6)
10:30 101.2
Human Proteomes – From Basic Science to
Understanding Drug Action. B. Kuster. Technical Univ., Munich
and Friesing, Germany.
10:55
Rapid
and
Reproducible
Proteotype
Acquisition from Biopsy Level Samples. T. Guo, R. Aebersold.
ETH Zurich. (602.2)
11:10
Mechanism of Action Identified in 30 Days: A
Systems Biology Approach. A. Vertes, A.R. Korte, C. LombardBanek, P. Nemes, L. Lida Parvin, Z.J. Sahab, B. Shrestha,
S.A. Stopka, W. Yuan, D.I. Bunin, M. Knapp, I. Mason, D.M.
Nishita, A. Poggio, C.L. Talcott, M. Yadav, B.M. Davis, A.I.
Larriera, C.A. Morton, C.J. Sevinsky, M.I. Zavodszky, N.J.
Morris, H.R. Anderson, M.J. Powell, T.T. Razunguzwa.
George Washington Univ., SRI Intl., Menlo Park, GE Global
Res., Niskayuna, NY and Protea Biosci. Inc., Morgantown, WV.
(819.2)
11:25 101.3
Proteotyping
for
Drug
Development:
Proteomics Impacting Clinical Practice. J. Van Eyk, R.
Holewinski, S. Wang, J. Kirk, D. Kass. Cedars-Sinai Med.
Ctr., Johns Hopkins Univ. and Loyola Univ. Chicago.
11:50
Discussion.
38
102. ALLOSTERIC CONTROL OF KINASE ACTIVITY
Symposium
Sun. 9:45 am—San Diego Convention Center, Room 6E
Chaired: S. Taylor
Follow the conversation: #cellsignal
9:45
9:50 102.1
Dimer Induced Regulation of Protein Kinase
Function. F. Sicheri. Lunenfeld-Tanenbaum Res. Inst., Mount
Sinai Hosp., Toronto.
10:15
Phosphorylation of Secreted Proteins by a
New Family of Kinases. V.S. Tagliabracci, S. Wiley, J. Dixon.
Univ. of Texas Southwestern and UCSD. (633.7)
10:30 102.2
How EGF and Insulin Activate Their Receptors.
D. Leahy. Johns Hopkins Univ. Sch. of Med.
10:55
Designing Allosteric Switches of Kinases. N.V.
Dokholyan, O. Dagliyan, K. Hahn. Univ. of North Carolina at
Chapel Hill. (633.6)
11:10
Protein Dynamics Defines Allostery in the
Conserved EPK Core. L.G. Ahuja, A.P. Kornev, C. McClendon,
G. Veglia, S.Taylor. UCSD and Univ. of Minnesota, Minneapolis.
(856.10)
11:25 102.3
Signaling in the Catalytic Subunit of
Protein Kinase A via Hydrophobic Motifs. G. Veglia. Univ. of
Minnesota, Minneapolis.
11:50
Discussion.
103. HEPATIC LIPID SIGNALING: NAFLD
AND BEYOND
Symposium
(Sponsored by: ASBMB Minority Affairs Committee)
Sun. 9:45 am—San Diego Convention Center, Room 6F
Chaired: D.D. Moore
Follow the conversation: #liver
9:45
9:50 103.1
Regulation of Liver Energy Balance by Nuclear
Receptors. D.D. Moore. Baylor Col. of Med.
10:15
Sphingosine-1-Phosphate Signaling in Nonalcoholic Steatohepatitis. L.A. Cowart. Med. Univ. of South
Carolina. (870.6)
10:30 103.2
Hedgehog Signaling in NAFLD. A.M. Diehl.
Duke Univ. Med. Ctr.
10:55
FTY720/fingolimod
Reduces
Steatosis
in a Murine Model of Non-alcoholic Fatty Liver Disease.
T.D. Rohrbach, A. Asgharpour, D. Avni, S.C. Cazanave, P.
Bedossa, A.J. Sanyal, S.D. Spiegel. Virginia Commonwealth
Univ. and Univ. Paris-Denis Diderot. (870.7)
11:10
Dual Activation of Bile Acid Receptors FXR
and TGR5 Plays a Protective Role in Non-alcoholic Fatty Liver
Disease and Atherosclerosis. K. Jadhav, Y. Xu, Y. Zhang.
Northeast Ohio Med. Univ. (870.4)
11:25 103.3
JNK Signaling in Hepatic Disease. R.J. Davis.
HHMI/Univ. of Massachusetts Med. Sch.
11:50
Discussion.
SUNDAYBIOCHEMISTRY
104. ADVANCING TEACHING AND LEARNING
IN THE BIOCHEMISTRY/MOLECULAR
BIOLOGY CLASSROOM
106. ASBMB INCENTIVIZING GREAT RESEARCH
Public Policy
Symposium
(Sponsored by: ASBMB Public Affairs
Advisory Committee)
(Sponsored by: ASBMB Education and Professional
Development Committee)
Sun. 12:30 pm—San Diego Convention Center, Room 6A
Chaired: C. Peterson
9:45
9:50 104.1
Take Your Medicine; It’s Good for You.
Teaching Quantitative Principles to Biologists. M. Springer.
Harvard Med. Sch.
10:15
Teaching a Broad Non-science Major Audience
Using the Science of Food and Cooking. J.J. Provost, B.
Kelly, K. Colabroy, M. Wallert. Univ. of San Diego, Gustavus
Adolphus Col., MN, Muhlenberg Col., PA and Bemidji State
Univ. (882.2)
10:30 104.2
The Collaborative Undergraduate Research
Lab: Using Yeast Genetics to Create an Authentic Research
Experience for Freshman. T. Johnson. HHMI, UCLA.
10:55
Is More Activity Always Better? A DepartmentWide Study of Relationships between Classroom Practices
and Student Performance. M.K. Barker, L. Weir, L. McDonnell,
N. Schimpf, T. Rodela, P. Schulte. Univ. of British Columbia,
Kwantlen Polytech Univ., Canada and UCSD. (662.17)
11:10
Breast Cancer in the Age of Personalized
Medicine: A CURE Design for Aspiring Physicians. P.A.G.
Soneral. Bethel Univ. (662.18)
11:25 104.3
Using Threshold Concepts to Improve BMB
Instruction – An Evidence-Based Approach. J. Loertscher,
J. Lewis, V. Minderhout, X. Xu. Seattle Univ. and Univ. of
South Florida.
11:50
Discussion.
105. ASBMB AWARD FOR EXEMPLARY
CONTRIBUTIONS TO EDUCATION LECTURE
Award Lecture
Undergraduate Student Research Poster Competition
Award Winners will be announced during this lecture.
12:30
12:35 105.1
Biochemistry and Molecular Biology Education
in a Transforming Academy and a Molecular World. C. Brenner.
Univ. of Iowa Carver Col. of Med.
This symposium will focus on analyzing counterproductive
pressures on scientists and how they can be managed to
incentivize outstanding research.
S
U
N
107. EARL AND THRESSA STADTMAN SCHOLAR
AWARD LECTURE I
Award Lecture
2:15
2:20 107.1
CRISPR-Cas, the Prokaryotic Adaptive
Immune System. L. Marraffini. The Rockefeller Univ.
108. RUTH KIRSCHSTEIN DIVERSITY IN SCIENCE
AWARD LECTURE
Award Lecture
2:40
2:45 108.1
Chemical Genetic Analysis
Activation. A. August. Cornell Univ.
of
Mast-Cell
109. AVANTI AWARD IN LIPIDS LECTURE
Award Lecture
(Sponsored by: Avanti Polar Lipids, Inc.)
3:15
3:20 109.1
Mechanisms and Physiology of Fat Synthesis
and Storage. R.V. Farese. Harvard Med. Sch.
110. TRANSLATIONAL SCIENTIST: INTEGRATING
SCIENCE AND MEDICINE
Symposium
(Supported by Guest Society: Society for Experimental
Biology and Medicine)
Cochaired: H.R. Gaskins and W.E. Zimmer
New Approaches in Medical Training of Health Researchers
M. J. Friedlander, Virginia Tech Carilion Res Inst
Forging Interactions Between Academia, Industry and Clinical
Health Care Providers M. Wood, AstraZeneca Neuroscience
39
BIOCHEMISTRYSUNDAY
111. REPLICATION: ALPHA TO OMEGA
113. REGULATION OF PROTEIN SYNTHESIS BY RNA
Symposium
Symposium
Sun. 4:00 pm—San Diego Convention Center, Room 6D
Chaired: A. Smogorzewska
Chaired: Y. Ye
Follow the conversation: #DNA
Follow the conversation: #proteins
4:00
4:05 111.1
Single-Molecule Studies of Eukaryotic DNA
Replication. S.P. Bell, S. Ticau, L.J. Friedman, J. Gelles. MIT
and Brandeis Univ.
4:30
Flexible Modes of Translocation by the
Eukaryotic CMG Helicase Facilitate Removal or Bypass of
DNA Blocks. L.D. Langston, M. O’Donnell. HHMI, Rockefeller
Univ. (578.4)
4:45 111.2
Structural Mechanisms for Initiating DNA
Replication. J. Berger. Johns Hopkins Univ. Sch. of Med.
5:10
Function of Cdc45 in DNA Replication and
in Response to Genotoxic Stress. A. DeBrot, C. Lancaster,
M-A. Bjornsti. Univ. of Alabama at Birmingham and St Jude
Children’s Res. Hosp. (798.2)
5:25
Breaking the Fourth Wall: Quaternary
Organizations Forge a Link to the Novel Non-enzymatic
Function of RNR-α. Y. Aye. Cornell Univ. and Weill Cornell
Med., Ithaca. (793.1)
5:40 111.3
Replisome Disassembly at the Termination
of Eukaryotic Replication Forks. A. Gambus. Univ. of
Birmingham, U.K.
6:05
Discussion.
4:00
4:05 113.1
Regulation of the mRNA Reading Frame.
C.M. Dunham, S. Sunita, J. Dunkle, T. Maehigashi. Emory
Univ. Sch. of Med.
4:30
Translational Recoding in Human Disease.
V.M. Advani, R.C. Kobylarz, J.D. Dinman. Univ. of Maryland
College Park. (1065.1)
4:45 113.2
Structured RNAs That Manipulate the
Translation Machinery. J.S. Kieft. Univ. of Colorado Med. Sch.
5:10
Coaxing a Viral RNA Out of Its Shell: How
Does a Viral RNA Genome Initiate Contact with Its Host?
R.W. Sportsman, C. Beren, B. Kartub, R. Garmann,
C. Knobler, W. Gelbart. UCLA and Harvard Univ. Sch. of
Engin. and Applied Sci. (599.3)
5:25
mRNA Quality Control Is Activated Due to
Chromium (VI) Mediated Oxidative Damage. N. GarciaDoherty, A.L. Larson, M. Six, S.P. Segal. Winona State Univ.
(599.1)
5:40 113.3
Ribosome-Based Quality Control of Chemically
Damaged mRNA. H. Zaher, C.L. Simms, B.H. Hudson.
Washington Univ. in St. Louis.
6:05
Discussion.
112. MECHANISTIC STUDIES
OF METALLOENZYMES
114. OMICS APPROACHES TO TARGET DISCOVERY
Symposium
Sun. 4:00 pm—San Diego Convention Center, Room 6C
Chaired: V. Bandarian
Follow the conversation: #catalysis
4:00
4:05 112.1
DNA-Mediated Signaling by Proteins with IronSulfur Clusters. J. Barton. Caltech.
4:30
New Insight Into the Role of ATP in Iron
Sulfur Cluster Scaffolding by the Mrp/Nbp35 Family of Cluster
Scaffolds. D.L. Perlstein, J. Grossman. Boston Univ. (608.5)
4:45 112.2
Biosynthesis of the FeFe Hydrogenase Active
Site. D.L.M. Suess, R.D. Britt. Univ. of California, Davis.
5:10
A Surprising Shift in the Biosynthesis of Marine
Meroterpenoids. Z. Miles, S. Deithelm, J. George, B. Moore.
UCSD and Univ. of Adelaide. (608.4)
5:25
New Function of Enzyme Involved in the
Formation of a Carbon-Nitrogen Triple Bond. M. Kobayashi.
Grad. Sch. of Life and Envrn. Sci., Univ. of Tsukuba. (1084.1)
5:40 112.3
Exploring the Mechanistic Diversity of
Non-heme-Iron Enzymes by Freeze-Quench Mössbauer
Spectroscopy. C. Krebs, J.M. Bollinger; Jr. Penn State.
6:05
Discussion.
40
Symposium
Sun. 4:00 pm—San Diego Convention Center, Room 6E
Chaired: J. Sello
Follow the conversation: #metabolism
4:00
4:05 114.1
Metabolomic Signatures of Antimycobacterial
Drug Mechanisms of Action. K. Rhee. Weill Cornell Med. Col.
4:30
A Role for Underlying Glycan Structure in
Influenza Binding: Extending the Species Specificity Paradigm.
R.J. Woods, O.C. Grant, J.A. Hadden, H.M.K. Smith, W. Peng,
R. De Vries, R. McBride, J.C. Paulson. Univ. of Georgia, Natl.
Univ. of Ireland, Galway, Univ. of Illinois at Urbana-Champaign
and The Scripps Res. Inst. (1103.6)
4:45 114.2
Toward a Functional, ChemoProteomic
Interrogation of Kinome and Nucleotide Binding Space. J.W.
Kozarich. ActivX Biosciences, La Joll.
5:10
De Novo Synthesis from Tryptophan in
the Absence of a QPRTase Homolog Contributes to NAD+
Biosynthesis in C. elegans. M.R. McReynolds, W. Wang, L.
Holleran, W. Hanna-Rose. Penn State. (849.1)
5:25
Mitochondrial Protein Functions Revealed by
Global Protein-Lipid-Metabolite Profiles. D.J. Pagliarini, J.A.
Stefely, N. Kwiecien, A. Hebert, M. Veling, A. Richards, A.
Ulbrich, A. Jochem, M. Rush, E. Freiburger, H. Marx, M.
Westphall, J. Coon. Morgridge Inst. for Res. and Univ. of
SUNDAYBIOCHEMISTRY
5:40 114.3
Lipidomics in Disease and Drug Discovery.
E.A. Dennis. UCSD.
6:05
Discussion.
115. MEMBRANE CONTACT SITES AND
LIPID TRAFFICKING
Symposium
Sun. 4:00 pm—San Diego Convention Center, Room 6F
Chaired: T. Walther
Follow the conversation: #lipids
4:00
4:05 115.1
Broadband Connections within the Cell:
How Mitochondria Talk to the Endomembrane. B. Kornman.
ETH Zurich.
4:30
An EE-Golgi Tether Facilitates Ceramide
Transfer Out of the ER and Alleviates Ceramide Toxicity.
L-K. Liu, A. Toulmay, W. Prinz. NIDDK, NIH. (660.1)
4:45 115.2
Extended-Synaptotagmins
as
Lipid
Transporters at ER-PM Contact Sites. K.M. Reinisch, C.
Schauder, X. Wu, Y. Saheki, P. Narayanaswamy, F. Torta, M.
Wenk, P. De Camilli. Yale Univ. Sch. of Med., Natl. Univ. of
Singapore and HHMI, New Haven, CT.
5:10
Phosphatidylserine Production at Membrane
Contacts Sites Enhances Its Transport Out of the Endoplasmic
Reticulum. M. Kannan, S. Lahiri, L-K. Liu, W.A. Prinz. NIDDK,
NIH and Univ. of Virginia. (660.2)
5:25
A Conserved Family of Proteins Facilitates
Nascent Lipid Droplet Budding from the ER. V. Choudhary, N.
Ojha, A. Golden, W.A. Prinz. NIDDK, NIH. (1132.1)
5:40 115.3
ER-Plasma Membrane Contact Sites Regulate
Sterol Import in Yeast. A. Menon, Y.Y. Sere, J. Johansen, E.
Quon, N. Chauhan, C.T. Beh. Weill Cornell Med. Col. and
Simon Fraser Univ., Canada.
6:05
Discussion.
116. INTEGRATING COMPLEMENTARY SKILLS INTO
GRADUATE AND POSTDOC TRAINING
4:30
Innovative Program That Broadens Career
Development Training through Community Partnerships and
Outreach. T.M. Evans. Grad. Sch. of Biomed., Sci., Univ. of
Texas Hlth. Sci. Ctr. at San Antonio. (663.1)
4:45 116.2
Lessons Learned from the Broadening
Experiences in Scientific Training (BEST) Awards. P. Labosky.
OSC, NIH.
5:10
Analysis of NIEHS Postdoctoral Alumni Career
Outcomes. T.R.L. Collins, R. Gilliam, S. Peddada, H. Xu.
NIEHS, NIH, Durham, NC. (883.2)
5:25
Changing Career Prospects Are Changing the
Needs in Graduate and Postdoc Training. S.E. Feeney. Univ.
of California, Davis. (663.3)
5:40 116.3
NIH/IRACDA Program – A Win for Both
Postdocs and PUI Partner Institutions. M.A. Carroll,
E.J. Catapane, M. Soto, G. Brewer. Medgar Evers Col./
CUNY, Brooklyn and Rutgers-Robert Wood Johnson Med.
Sch., Piscataway.
6:05
Discussion.
118. CRISPR: POWER AND CHALLENGES
Workshop
Follow the conversation: #dna
6:30 118.1
CRISPR-Cas9: Power and Challenges.
E. Charpentier. Max Planck Inst. for Infect. Biol., Berlin,
Helmholtz Ctr. for Infect. Res., Germany, Umeå Univ., Sweden
and Hannover Med. Sch., Germany.
6:30 118.2
The Asymmetric Interaction of Cas9 with
Target DNA Can Promote High Efficiency Homology-Directed
Genome Editing. J.E. Corn, C.D. Richardson, J. Ray, G.
Curie, M. DeWitt. Univ. of California, Berkeley.
6:30 118.3
Globally
Monitoring
Protein
Synthesis
in Time and Space hrough Ribosome Profiling.
J. Weissman. UCSF/HHMI.
119. WELCOME RECEPTION SPONSORED BY THE
ASBMB MINORITY AFFAIRS COMMITTEE
Symposium
Special Event
Sun. 7:30 pm—San Diego Marriott Marquis & Marina
Hotel, Marina Ballroom D
Chaired: S.H. Oyewole
A professional networking event featuring ASBMB Graduate
Student Travel Award research posters. ASBMB members and
biochemistry registrants welcome.
4:00
4:05 116.1
Individual Development Plans: Determining
Your Strengths, Identifying Areas for Improvement, and
Initiating Conversations about Your Career. Y.R. Seger. Ofc. of
Publ. Affairs, FASEB.
EB 2016?
41
S
U
N
NUTRITIONSUNDAY
Nutrition
120. ASN SPONSORED SATELLITE PROGRAM:
BACK TO THE FUTURE? ANCIENT GRAINS AND
SPROUTING FOR ENHANCED NUTRITION
ASN Satellite
(Organized and Sponsored by: The Kellogg Company)
Sun. 6:30 am—San Diego Convention Center, Room 33BC
Programs, please visit http://scientificsessions.nutrition.org/
satellitesessions/.
121. NUTRITIONAL EPIDEMIOLOGY RIS BUSINESS
MEETING, MIXER AND MENTORING EVENT
Sun. 7:00 am—Hilton San Diego Bayfront, Indigo C
122. OPTIMIZING THE AGING BRAIN
THROUGH NUTRITION
Symposium
Ballroom 20D
Chaired: S.N. Meydani
Cochaired: N. Surzenko
(Nutrition Across the Lifespan: From Pediatrics
to Geriatrics
8:00
8:25
8:50
9:15
9:40
The Aging Brain: Current Knowledge and Future
Possibilities. D. Steindler. Jean Mayer USDA HNRC
on Aging at Tufts Univ.
Nutrients, Cognitive Development and the Potential
of Personalized Nutrition. S. Zeisel. Univ. of North
Carolina at Chapel Hill.
Diet and Cognitive Function: What Works and How Do
we Measure It? A. Scholey. Swinburne Univ.
Nutrients and the Aging Brain: Insights from Studies
with Nutrients, Brain Injuiry and Imaging Techniques.
A. Barbey. Beckman Inst. for Advanced Sci. and
Technol. at the Univ. of Illinois.
Panel Discussion. D. Klurfeld. USDA, Beltsville.
Visit the Exhibits
April 3–April 5
Exhibit Hours
Sunday–Tuesday
9:00 AM–4:00 PM
42
123. DELIVERING NUTRITION INTERVENTIONS
TO WOMEN DURING PREGNANCY:
BEYOND INDIVIDUAL INTERVENTIONS TO
COMPREHENSIVE ANTENATAL GUIDELINES
AND CARE
Symposium
Sun. 8:00 am—San Diego Convention Center, Room 31ABC
(Cosponsored by: L.M. De-Regil)
Chaired: R.J. Stoltzfus
Cochaired: L.M. De-Regil
Global and Community Nutrition
8:00Introduction. R.J. Stoltzfus. Cornell Univ.
8:10 Nutrition in Antenatal Care: History and Current
Guidance. E. Phillips. Independent Consultant.
8:35 Experiences, Options and Challenges of Delivering
Exclusive Breastfeeding Counseling in Pregnancy.
M. Mbuya. Zvitambo Inst. for Maternal Child Hlth.
9:00 Experiences, Options and Challenges of Delivering
Micronutient Interventions in Pregnancy. K. Dickin.
Cornell Univ.
9:25 An Integrative Research Agenda: Health Systems
Strengthening and Integrating Nutrition into ANC.
C. Taylor. Management Sci. for Hlth.
124. EXPERIMENTAL ANIMAL NUTRITION:
ANIMAL MODELS FOR NUTRITION ACROSS
PHYSIOLOGICAL STATES
Minisymposium
(Sponsored by: Experimental Animal Nutrition RIS)
Chaired: C.L. Levesque
Cochaired: K.M. Ajuwon
8:00 124.1
Enriching the Maternal Diet in Long Chain
n-3 Polyunsaturated Fatty Acids Alters Lipid Metabolites and
Adiposity in Broiler Chicks. R. Beckford, S. Howard, S. Das,
A. Tester, S. Campagna, J. Whelan, J. Wilson, B. Voy. Univ. of
Tennessee, Knoxville and Univ. of Georgia.
8:15 124.2
Maternal Vitamin A Supplementation Expands
Adipose Progenitor Population through Promoting Vascular
Development. B. Wang, X. Fu, S. Zhang, X. Liang, M. Zhu, M.
Du. Washington State Univ.
8:30 124.3
Long-Term Leucine and BCAA Inclusion in a
30% Protein and Energy Restricted Diet Increases mTORC1
Signaling in Skeletal Muscle of Neonatal Pigs. R. Manjarin,
D.A. Columbus, J. Solis, A. Suryawan, A.D. HernándezGarcía, H.V. Nguyen, M.L. Fiorotto, T. Davis. Baylor Col. of
Med. and Cal Polytech State Univ., San Luis Obispo.
SUNDAYNUTRITION
8:45 124.4
Resveratrol Consumption and RIP140
Knockout Mice Demonstrate a Novel Relationship between
Increased Mitochondrial Content and Compromised Bone
Mineral Mass, Microarchitecture, and Strength. P.M. Miotto,
S. Frendo-Cumbo, S.M. Sacco, D.C. Wright, W.E. Ward, G.P.
Holloway. Univ. of Guelph and Brock Univ., Canada.
9:00 124.5
Pigs Fed a Western Diet Develop Elevated
Fasting Glucose and a Microbiome Analogous to Human
Obesity. K. Hintze, L. Cox, M. Lefevre, S.C. Isom. Utah
State Univ.
9:15 124.6
Soluble and Insoluble Fiber Differentially
Impact Canine Fecal Microbiome and Circulating Metabolome.
M.I. Jackson, D.E. Jewell. Hill’s Pet Nutr., Topeka.
9:30 124.7
Do Standard Laboratory Practices Lead to
Obese Zebrafish Populations? S.A. Watts, L. Dennis, L.A.
Fowler, M.B. Williams, Y. Yuan, R.J. Barry, S. Farmer, L.R.
D’Abramo, M.L. Powell. Univ. of Alabama at Birmingham.
9:45 124.8
Effects of Food Matrix and Western Diet on
Colorectal Cancer and Metabolism in C57BL/6 Mice. K. Hintze,
T. Hisatome, S. Kellen, R. Ward, A. Benninghoff, M. Lefevre.
Utah State Univ.
125. DBC: BIOACTIVE DIETARY PROTEINS
Minisymposium
(Sponsored by: Dietary Bioactive Components RIS)
Chaired: E. deMejia
8:00 125.1
Identification of Glycoproteins on the
Surface of Cow’s Milk Exosomes That Mediate the Uptake
of Exosomes into Human Colon Carcinoma Caco-2 Cells.
S. Sukreet, H. Zhang, J. Adamec, J. Cui, J. Zempleni. Univ.
of Nebraska-Lincoln.
8:15 125.2
Replacing Pork and Chicken with Herring
(Clupea harengus) Increases Plasma Glucosamine and
Decreases Carbon Flux through the Citric Acid Cycle in
Overweight Men and Women. A. Ross, A. Vincent, O.
Savolainen, H. Lindqvist, M.V. Lind, A-S. Sandberg.
Chalmers Univ. of Technol. and Gothenburg Univ., Sweden.
8:30 125.3
Long-Term Feeding of a Soy-Protein-Based
Diet Improves Trabecular and Cortical Bone Outcomes in LowFit, Intact and Ovariectomized Female Rats. M.W. Richard,
L.C. Ortinau, T.M. Zidon, P.S. Hinton, V. Vieira-Potter. Univ.
8:45 125.4
Modulation of Cerebral Activity Induced by
α-Casozepine, a Benzodiazepine-Like Peptide Derived from
Bovine Casein. S. Benoit, C. Chaumontet, Cakir-Kiefer, D.
Tomé, L. Miclo. AgroParisTech, INRA, Univ. Paris-Saclay and
Univ. de Lorraine-Nancy, France.
9:00 125.5
Collagen Peptides Derived from Alaska
Pollock Skin Protect against TNFα-Induced Dysfunction of
Tight Junctions in Caco-2 Cells. Q. Chen, B. Li, I. Martin, J.B.
Blumberg, C-Y.O. Chen. Ocean Univ. of China, USDA at Tufts
Univ. and State Univ. of Campinas, Brazil.
9:15 125.6
Antidiabetic Effect of Black Bean Peptides
through Reduction of Glucose Absorption and Modulation of
SGLT1, GLUT2 and DPP-IV in In Vitro and In Vivo Models. L.
Mojica, E.G. DE MEJIA, M. Menjivar, M. Granados-Silvestre.
Univ. of Illinois, Urbana and UNAM, Mexico City.
9:30 125.7
Early Intervention with Dietary Fish Oil, Flax
Oil and Soy Protein in Three Orthologous Rodent Models of
Human Hereditary Polycystic Kidney Disease. J.G. Devassy, T.
Yamaguchi, Md. Monirujjaman, M. Gabbs, M. Morrish, H.M.
Aukema. Univ. of Manitoba, St Boniface Hosp. Res. Ctr. and
Manitoba Inst. of Child Hlth., Winnipeg.
9:45 125.8
The Effect of Wheat Peptides on EthanolInduced Gastric Mucosal Damage in Rats. X. Yang, G. Sun, S.
Wang. Sch. of Publ. Hlth., Southeast Univ., China.
126. OBESITY: CHRONIC DISEASE
S
U
N
Minisymposium
(Sponsored by: Obesity RIS)
Chaired: A. Brown
8:00 126.1
Echocardiography Evaluation as a Marker
of Cardiovascular Risk on Obese Children and Adolescents.
C.A. Nogueira-de-Almeida, S.H. Caixe, A.C.G.S. Benedeti,
J. Garcia. Univ. of Ribeirão Preto and UNAERP/Fatesa,
Ribeirão Preto, Brazil.
8:15 126.2
Effect of Salba-Chia (Salvia hispanica L), an
Ancient Seed, in the Treatment of Overweight and Obese
Patients with Type 2 Diabetes: A Double-Blind, Parallel,
Randomized Controlled Trial. A.L. Jenkins, C. Brissette,
E. Jovanovski, F. Au-Yeung, H.V.T. Ho, A. Zurbau, J.
Sievenpiper, V. Vuksan. St. Michael’s Hosp., Toronto, Univ. of
Toronto and Li Ka Shing Knowledge Inst.,Toronto.
8:30 126.3
A Systematic Examination of the Association
between Parental and Child Obesity: Systematic Review and
Meta-analysis. Y. Wang, J. Min, J. Khuri, M. Li. Sch. of Publ.
Hlth. and Hlth. Professions, Univ at Buffalo SUNY.
8:45 126.4
Therapeutic Potential of AICAR in Attenuating
Obesity-Induced Metabolic, Liver and Kidney Disease.
E. Borgeson, V.W. Borgeson, C. Godson, K. Sharma.
Univ. of Gothenburg, Sweden, University Col. Dublin, Ireland
and UCSD.
9:00 126.5
Berberine Ameliorates Hepatic Steatosis and
Suppresses Liver and Adipose Tissue Inflammation in Obesity
Mice Independent of AMPK. S-L. Woo, T. Guo, X. Guo, H. Li,
J. Zheng, R. Botchlett, Y. Cai, X. Li, Q. Li, X. Xiao, Y. Huo, C.
Wu. Texas A&M Univ., Hubei Hosp. of Chinese Med., Wuhan,
The First Hosp. of CMU, China and Georgia Regents Univ.
9:15 126.6
Delta-Tocotrienol Regulates Lipid Metabolism
in Livers of High Fat Fed Mice. L. Ramalingam, L. Allen, S.
Scoggin, K. Gurvinder, M.D. Tomison, C-L. Shen, E. Chung,
J. Dufour, N. Moustaid-Moussa. Texas Tech Univ. and Texas
Tech Hlth. Sci. Ctr.
9:30 126.7
Secretory Factors Produced by Stromal
Cultures of Human Omental Adipose Tissue Inhibit Adipose
Differentiation. R.T. Pickering, M-J. Lee, M. Jager, M. Layne,
S.K. Fried. Boston Univ. Sch. of Med.
9:45 126.8
Obesity Prevention by Calorie Restraint
Using the Bathroom Scale Model Prevents Hypertension for
Life in Nonhuman Primates. B.C. Hansen, E.H. Linden, J.D.
Newcomb. Univ. of South Florida Morsani Col. of Med.
43
NUTRITIONSUNDAY
127. NUTRIENT-GENE INTERACTIONS: GENOMICS,
PROTEOMICS, AND METABOLOMICS
Minisymposium
(Sponsored by: Nutrient-Gene Interactions RIS)
Chaired: T.T. Wang
8:00 127.1
Depletion of Dietary MicroRNAs from Cow’s
Milk Causes an Increase of Purine Metabolites in Human
Body Fluids and Mouse Livers. A.G. Aguilar Lozano, S.
Baier, J. Adamec, M. Sadri, D. Giraud, J. Zempleni. Univ.
8:15 127.2
Gene, Sex and Diet Interact to Control the
Tissue Metabolome. A. Wells, W. Barrington, D. Threadgill, S.
Dearth, S. Campagna, A. Saxton, B. Voy. Univ. of Tennessee
and Texas A&M Univ.
8:30 127.3
A Genome-Wide Association Study of Plasma
α2-Macroglobulin Concentrations in Young Adults. J. Jamnik,
C. Borchers, A. El-Sohemy. Univ. of Toronto and Univ. of
Victoria, Canada.
8:45 127.4
Genetic Influence on Xanthine Oxidase Activity
and Arginine Metabolites in Hispanic Children. V.S. Voruganti,
G. Chittoor, K. Haack, S. Laston, I. Vazquez-Vidal, N.R.
Mehta, A.G. Comuzzie, S.A. Cole, N.F. Butte. Univ. of North
Carolina at Chapel Hill, Kannapolis, Texas Biomed. Res. Inst.,
San Antonio, Univ. of Texas at Rio Grande Valley and Baylor
Col. of Med.
9:00 127.5
Interaction between PhIP from Meat Intake
and Polymorphism in Superoxide Dismutase 2 Gene Increases
Risk of Oxidative Stress. A. Carvalho, J. Steluti, A.A. Carioca,
A.P. Loureiro, G. Gattas, R. Fisberg, D. Marchioni. Univ. of
São Paulo.
9:15 127.6
LCT Gene Variant -13910 C<T, Dairy Intake,
and 25-Hydroxyvitamin D Plasma Levels: A Mendelian
Randomization Study. O. Alharbi, A. El-Sohemy. Univ.
of Toronto.
9:30 127.7
Genetic Variation in the Sucrase-Isomaltase
(si) Gene Is Associated with Dietary Intake in a Young Adult
Population. R. Sorkin, T. Wolever, A. El-Sohemy. Univ.
of Toronto.
9:45 127.8
Association
between
LCT-13910
C>T
Genotype and Plasma 25-Hydroxyvitamin D with Premenstrual
Symptoms. A.C. Jarosz, O. Alharbi, A. El-Sohemy. Univ.
of Toronto.
128. VITMIN: WATER AND FAT SOLUBLE VITAMINS
AND CHRONIC DISEASE, MICRONUTRIENT
BIOVAILABILITY AND ANTIOXIDANT FUNCTION
Minisymposium
(Sponsored by: Vitamins and Minerals RIS)
Chaired: J. Finkelstein
Cochaired: S. Ajabshir
8:00 128.1
The Role of Vitamin D in Obesity and Diabetes:
Ca2+ Signaling, Insulin Secretion, Adipocyte Apoptosis, and
Bone Mineralization. I.N. Sergeev. South Dakota State Univ.
44
8:15 128.2
1,25-Dihydroxyvitamin D Regulates Energy
Substrate Metabolism to Reduce Triacylglycerol Accumulation
in 3T3-L1 Adipocytes. B.M. Larrick, K-H. Kim, S.S. Donkin, D.
Teegarden. Purdue Univ.
8:30 128.3
Body Mass Index Is a Strong Predictor of
Low Serum 25(OH)D Levels in Multiethnic Obese Children
in Western Massachusetts. S. Kannan, P. Visintainer, H.B.
Ganguri, C. Wittcopp. So. Illinois Univ. Carbondale, Tufts
Univ. Sch. of Med., Baystate Med. Ctr., Springfield, MA and
Kronsys, Raleigh, NC.
8:45 128.4
Placental Megalin and Cubilin Expression Is
Associated with Markers of Vitamin D Status but Not Fetal
Bone Growth during Adolescent Pregnancy. C.M. Whisner,
C.E. Thomas, K.O. O’Brien. Sch. of Nutr. and Hlth. Promotion,
Arizona State Univ. and Cornell Univ.
9:00 128.5
Urinary α-CEHC Predicts α-Tocopherol Status
in Healthy Adults and Those with Metabolic Syndrome. M.G.
Traber, S.W. Leonard, E. Mah, G. Bobe, R.S. Bruno. Oregon
State Univ., The Ohio State Univ. and Biofortis Clin. Res.,
Addison, IL.
9:15 128.6
Development of a Model for In Vitro
Comparative Absorption of Magnesium from Five Magnesium
Sources Commonly Used as Dietary Supplements. J.W. Hartle,
S. Morgan, T. Poulsen. Albion, UT.
9:30 128.7
Assessing the Relationship of Vitamin D with
Iron Status in Children with Inflammatory Bowel Disease.
S. Syed, E.M. Smith, V. Tangpricha, S. Chesdachai, A.
Kumar, J. Prince, T.R. Ziegler, P.S. Suchdev, S. Kugathasan.
Emory Univ.
9:45 128.8
Effects of Whole Egg Consumption on Vitamin
E Absorption from Co-consumed, Mixed-Vegetable Salad.
J.E. Kim, M.G. Ferruzzi, W.W. Campbell. Purdue Univ.
129. COMMUNITY AND PUBLIC HEALTH NUTRITION:
FOOD ENVIRONMENT
Minisymposium
(Sponsored by: Community and Public Health
Nutrition RIS)
Chaired: L. Jahns
Cochaired: S. Colby
8:00 129.1
Assessment of Home Food Environment
among Healthy Weight and Overweight/Obese School-Age
Children. M.J. Nepper, W. Chai. Univ. of Nebraska-Lincoln.
8:15 129.2
The Impact of Neighborhood Food Environment
on School Meal Participation Rates. N. Vaudrin, P. OhriVachaspati, J. Green, C. Lorts, M. Yedidia. Sch. of Nutr. And
Hlth. Promotion, Arizona State Univ. and Rutgers Univ.
8:30 129.3
Availability and Price of Fruits and Vegetables
at Food Retailers in Western Massachusetts Counties.
Q. Jiang, J. Burdick, J. Chaiken, S. Walsh, N. Cohen. Univ. of
Massachusetts Amherst.
8:45 129.4
It’s Not How Much Your Spend, It’s Where You
Spend It: How Consumer Behavior Predicts Dietary Energy
Density. A. Massedge, J.A. Vernarelli. Fairfield Univ.
9:00 129.5
A More Efficient Method of Assessing Corner
Store Healthfulness. R. DeWeese, M. Todd, A. Karpyn, M.
Yedidia, M. Kennedy, M. Bruening, C. Wharton, P. OhriVachaspati. Arizona State Univ., Univ. of Delaware and
Rutgers Univ.
SUNDAYNUTRITION
9:15 129.6
What Do Parents and Children Talk about While
Grocery Shopping? A Content Analysis of Shopping Trips.
E. Calloway, A. Pritchard, C. Roberts-Gray, S. Sweitzer,
M. Briley. Gretchen Swanson Ctr. for Nutr., Omaha, Univ. of
Texas at Austin and Third Coast Res., Galveston.
9:30 129.7
Comparison of Food Availability in School
Stores in Seoul, South Korea before and after Implementation
of Two National Food- and Nutrient-Based Policies. S.K. Choi,
E.A. Frongillo, C.E. Blake, J.F. Thrasher. Arnold Sch. of Publ.
Hlth., Univ. of South Carolina.
9:45 129.8
A Novel Approach for Determining the
Environmental Impacts of Individual Food Choices in the United
States. D. Rose, M. Heller, A. Willits-Smith, A.R. Mundorf,
G. Keoleian. Tulane Univ. and Univ. of Michigan.
130. ENERGY AND MACRONUTRIENT METABOLISM:
DIETARY FATTY ACIDS AND HEALTH
Minisymposium
(Sponsored by: Energy & Macronutrient Metabolism RIS)
8:00 130.1
DHA Is More Potent Than EPA in Attenuating
Cardiometabolic Risk in Men and Women: A Randomized
Double-Blind, Placebo-Controlled Crossover Trial. J. Allaire,
P. Couture, A. Charest, M. Leclerc, J. Marin, M-C. Lépine, A.
Tchernof, B. Lamarche. Univ. Laval and Univ. Inst. of Cardiol.
and Pneumol. of Québec.
8:15 130.2
Assessing the Role of Saturated Fats in
Adipose Tissue Inflammation. M. Morgan-Bathke, W. Faubion,
M. Jensen. Mayo Clin. and Viterbo Univ., WI.
8:30 130.3
Effect of Omega-3 Polyunsaturated Fatty Acids
on Insulin Resistance Are Sex-Dependent: A Meta-Analysis of
Randomized Controlled Trials. M.L. Garg, K. Abbott, R. Thota,
S. Acharya, T.L. Burrows. Univ. of Newcastle, Wallsend
and Callaghan and NSW Dept. of Hlth., New Lambton
Hgts., Australia.
8:45 130.4
Short-Chain Fatty Acids, 4-Phenylbutyric Acid and
R-Alpha-Lipoic Acid, Improve mTORC1-Driven Overproduction of
apoB-Containing Triacylglyceride-Rich Lipoproteins. R. Moreau,
J.L. Roberts, B. He, A. Erickson. Univ. of Nebraska-Lincoln.
9:00 130.5
Effects of Corn Oil, Compared to Extra Virgin
Olive Oil, Intake on Lipoprotein and Subfraction Cholesterol
Levels in Men and Women: Results from a Randomized,
Controlled Feeding Study. K.C. Maki, A.L. Lawless, K.M.
Kelley, V.N. Kaden, C.J. Geiger, O.M. Palacios, M.R. Dicklin.
Midwest Ctr. for Metab. & Cardiovasc. Res., Glen Ellyn, IL,
Biofortis Innovation Svcs./Merieux NutriSci., Addison, IL and
Geiger & Assocs. LLC, Fort Bridger, WY.
9:15 130.6
Obesity and Dietary Fat Modulate HDL
Function in Adolescents: Results from a Cross-Sectional
Analysis and a Randomized, Placebo-Controlled, Crossover
Trial. A.M. McMorrow, M. O’Reilly, R.M. Connaughton, E.
Carolan, D. O’Shea, F.E. Lithander, F.C. McGillicuddy, H.M.
Roche. University Col. Dublin, St Vincent’s Univ. Hosp., Dublin
and Univ. of Canberra.
9:30 130.7
Dietary Linoleic Acid Increases Linoleic- and
Arachidonic Acid-Derived Bioactive Lipids, Despite Not Altering
Tissue Fatty Acid Levels. S.M. Leng, H.M. Aukema. Univ. of
Manitoba and CCARM, Winnipeg.
9:45 130.8
Effect of Plant Sources of Omega-3 PUFA on
Mood Status in Healthy Subjects: A Crossover Feeding Trial.
W.M. Young. Loma Linda Univ.
131. NUTRITION TRANSLATION: NUTRITION
AND FOOD SCIENCE FOR PUBLIC POLICY,
PRACTICE AND THE CONSUMER
Minisymposium
(Sponsored by: Nutrition Translation RIS)
Chaired: L. Sanders
Cochaired: E. Glynn
8:00 131.1
Does the Left Hand Know What the Right Hand
Is Doing? Part I: Alignment between the AFRI Foundational
Function and Efficacy of Nutrients Program and the 2010
Dietary Guidelines. M.M. Koeninga, K. Krishnan, C. Perez,
D.N. Chester. Natl. Inst. of Food and Agr., Washington, DC and
Texas A&M, Bryan.
8:15 131.2
Advancing Systematic Review Methodology to
Better Inform Food and Nutrition Policy. T.L. Psota, M. Spill,
J. Spahn, D. Gungor, K. Johns, P. Nadaud, Y.P. Wong, E.
Essery Stoody, C. Rihane. USDA, Alexandria, VA.
8:30 131.3
Adherence to the 2015 Dietary Guidelines for
Americans and Risk of Healthy and Unhealthy Obesity among
Canadian Adults. M. Jessri, W. Lou, M. L’Abbe. Dalla Lana
Sch. of Publ. Hlth., Univ. of Toronto.
8:45 131.4
Foods Consumed from Non-school Cafeterias
and Vending Machines: NHANES 2006-2012. S.J. Onufrak.
Ctrs. for Dis. Control and Prevent.
9:00 131.5
Children Are Eating Savory Snack Foods: What
We Eat in America, NHANES 2011-2012. D.G. Rhodes, J.C.
Clemens, M.A. Hymes, A.J. Moshfegh. USDA, Beltsville, MD.
9:15 131.6
Nutrient Profiling for the reformulation of
Pizza: Modelled Impact on Nutritional Intake in the U.S. Adult
Population. G. Masset, A. Vlassopoulos, U. Lehmann. Nestlé
Res. Ctr., Lausanne.
9:30 131.7
Are Foods of Higher Nutritional Quality More
Expensive Than Their Less Healthy Counterparts? An Analysis
of Canadian Packaged Foods. M-E. Labonté, S. Noorhosseini,
J. Bernstein, M. Ahmed, M. L’Abbé. Univ. of Toronto.
9:45 131.8
Mapping Inflammation and Cancer-Modifying
Regions in Broccoli Genome. W. Bussler, J. Alley, H. Chandler,
C. Thetford, G. Yousef, A. Brown, D. Esposito, M.A. Lila, S.
Komarnytsky. North Carolina State Univ., Kannapolis and
Raleigh, Iowa State Univ. and Catawba Col., NC.
132. INNOVATIONS IN UNDERGRADUATE,
GRADUATE AND MEDICAL
NUTRITION EDUCATION
Minisymposium
Assoc. of Nutrition Departments and Programs
Chaired: M.L. Dunn
8:00 132.1
Spicing
Up
Introductory
Nutrition.
D.A. Levitsky. Cornell Univ.
8:15 132.2
University Nutrition Programs– Training
Students for Careers beyond Dietetics: Reflections from an
Established, Emerging, and New Program. H.J. Willis, M.L.
Stewart, D.E. Smith. St. Catherine Univ., Univ. of Hawaii at
Manoa and Univ. of Minnesota, St. Paul.
45
S
U
N
NUTRITIONSUNDAY
8:30 132.3
Managing
the
Growing
Classroom:
Opportunities for Postdoctoral Teaching Fellows. J.E.H. Nevins,
A.L. Wilkinson. Cornell Univ.
8:45 132.4
Reinforcing Nutrition and Core Science
Fundamentals through a Multi-semester Research Project.
W.A. Clark, M.E. Johnson. East Tennessee State Univ.
9:00 132.5
Development
and
Evaluation
of
the
Transdisciplinary Obesity Prevention Research Sciences
Program. D. Teegarden, J. Bowers, A. Hammons, L.
Destefano, G. Garcia, B. Koester, L. Parker, A. Childress, B.
Fiese. Purdue Univ., Univ. of Illinois at Urbana-Champaign and
California State Univ., Fresno.
9:15 132.6
Innovations in Course Design to Facilitate
Understanding, Retention, and Application of Regulation of
Macronutrient Metabolism. A.Thalacker-Mercer, R. Vanderlan.
Cornell Univ.
9:30 132.7
The Impact of Linking Immigrants with Nutrition
Knowledge Initiative on Improving Cultural Competency
Skills among Nutrition and Dietetic Students in Canada.
H. Vatanparast, C. Henry, S. Mulhall. Univ. of Saskatchewan.
9:45 132.8
A New Model for Incorporating Nutrition Into the
Medical School Curriculum. M. Yakub, G. Al-Eyd, H. Atamna,
D. Atapattu, L. Castro, J. Estrada, S. Lakhan, F. Nausheen,
T. Seki, A. Tenore, A. Velji, R. Suskind. California Univ. of Sci.
and Med., Col. of Med.
133. OPENING SESSION AND DISCUSSION:
SCIENTIFIC RIGOR IN THE NUTRITION
RESEARCH LANDSCAPE
268. INTERNATIONAL FORUM – TAIWAN
10:30 Metabolomics and the Physiology of Exercise and
Insulin Resistance. S. Adams. Univ. of Arkansas for
Med. Sci.
11:00 The Sphingolipidome and Insulin Resistance:
Perspectives Gained from Studying the Overweight
Dairy Cow Transitioning From Gestation to Lactation.
J. McFadden. West Virginia Univ.
11:30 Genes, Exercise and Angiogenesis: Implications for the
Metabolome. M. Olfert. West Virginia Sch. of Med.
12:00 Metabolic Processes and Physiological Parameters
Involved with the Ischemia/Reperfusion Protective
Phenotype in Hibernators. L. Bogren. Univ. of
Colorado Anschutz Med. Campus, Aurora.
12:15 Depletion of Dietary MicroRNAs from Cow’s Milk Causes
International Forum
(Supported by The Nutrition Society of Taiwan )
(Organized and Sponsored by: The Nutrition Society
of Taiwan)
Mon. 8:30 am—San Diego Convention Center, Room 32AB
Chaired: F-Y. Tang
Cochaired: E-P.I. Chiang
This session will introduce the research interests and the
national nutrition survey of B vitamins in Taiwan. In addition, the
organizers will provide a platform for the exchange of information
and the promotion of international collaboration and cooperation
in nutrition research for scientists, dieticians, education
professionals, investigators and industry.
8:30
Thiamin and Riboflavin Status in Taiwan and our Coping
Strategy. F.L. Yang. Fu Jen Catholic Univ., Taiwan.
8:50
Vitamin B-6 and Homocysteine with Inflammation and
Oxidative Stress in Certain Diseases. Y-C. Huang.
Chung Shan Med. Univ.
9:10
1-Carbon Metabolic Kinetics in Human Disease Models.
E-P. Chiang. Natl. Chung Hsing Univ.
9:30 Taiwan Folate Nutrition in Cancer Co-therapeutic
Medicine: From Basic Research to Public Health and
Clinical Application. R-F. Huang. Fu Jen Catholic
Univ., Taiwan.
9:50Discussion.
46
Special Session
(Sponsored by: ASN, Canadian Nutrition Society, ILSI
North American and the Institute of Medicine.)
Ballroom 20D
Chaired: P.J. Stover
134. OMICS APPLICATIONS IN
METABOLIC PHYSIOLOGY
Symposium
(Cosponsored by: The American Physiological Society)
Chaired: S.H. Adams
Cochaired: M. Olfert
DIETARY PROTEIN: CURRENT PERSPECTIVES
ASN Satellite
(Organized and Sponsored by: PepsiCo)
Sun. 12:45 pm—San Diego Convention Center, Room 33BC
satellitesessions/.
SUNDAYNUTRITION
136. NUTRIENT-GENE INTERACTION RIS BUSINESS
MEETING AND SCIENTIFIC DISCUSSION:
BIOMARKERS DEFINED
RIS Forum
140. FOOD SYSTEMS FOR PUBLIC HEALTH:
ASSESSMENT, IMPACT AND IMPLICATIONS OF
MEETING FRUIT AND VEGETABLE CONSUMPTION
RECOMMENDATIONS ON ENVIRONMENTAL,
ECONOMIC AND AGRICULTURAL SUSTAINABILITY
(Sponsored by: Nutrient-Gene Interaction RIS)
Symposium
Ballroom 20D
Chaired: T.T. Wang
Chaired: J.W. Finley
NEW FRONTIERS IN FIBERS: INNOVATIVE
TECHNOLOGY AND EMERGING RESEARCH ON
GUT MICROBIOME AND BONE HEALTH
ASN Satellite
(Organized and Sponsored by: Tate & Lyle)
Sun. 12:45 pm—San Diego Convention Center, Room 32AB
satellitesessions/.
138. VITAMINS AND MINERALS RIS BUSINESS MEETING
AND OUTSTANDING RESEARCHER SHOWCASE
RIS Forum
Sun. 1:00 pm—San Diego Convention Center, Room 28DE
3:00
The Challenge of Feeding Nine Billion. D. Dimick. Natl.
Geographic Soc.
3:20
Modelling the Impact of Increasing Fruit and Vegetable
Consumption on the U.S. Agricultural System.
E. Marshall. USDA Economic Res. Svc.
3:40 Climate Change and Water Resource Impacts on
US Fruits and Vegetables. C. Rosenzweig. NASA
Goddard Inst. for Space Studies.
4:00 Changing Consumption/Demand for Vegetables
with Breeding/Decreasing Post-harvest Loss.
J. Mein. Monsanto.
4:20
Achieving Sustainable Nutrition Security: The Essential
Role of Partnerships. D. Gustafson. ILSI Res. Fndn.
141. HERITABLE FACTORS AND COMPLEX
DISEASES: USING GENETIC EPIDEMIOLOGY
TO DRAW INFERENCES ABOUT NUTRITIONDISEASE RELATIONSHIPS
Chaired: L. Tussing-Humphreys
Symposium
Sun. 3:00 pm—San Diego Convention Center, Room 31ABC
139. ROBERT SUSKIND AND LESLIE LEWINTERSUSKIND PEDIATRIC NUTRITION LIFETIME
ACHIEVEMENT AWARD
Chaired: K. Kordas
Cochaired: A.E. Millen
Award Lecture
Ballroom 20D
Nutrition Education: Have We Finally Found the Way to
Prepare Tomorrow’s Physicians? R.M. Suskind
S
U
N
Cochaired: J.R. Mein
3:00
Observational Studies in Nutrition: Limitations & Need
for Alternatives. K. Kordas. Univ. of Bristol.
3:25
Genes and Nutrition in the Post-GWAS Era. H. OchsBalcom. Univ. at Buffalo SUNY.
3:50
Mendelian Randomization: Principles and Applications
in Nutritional Sciences. C. Engelman. Univ.
of Wisconsin-Madison.
4:15 Limitations to Mendelian Randomization: Threats to
Causal Inference and Ways to Overcome Them.
N. Davies. Univ. of Bristol.
4:40 What Can Epigenomie-wide Assocation Studies
(EWAS) Tell Us About the Link between Nutrition and
Health? M. Suderman. Univ. of Bristol.
47
NUTRITIONSUNDAY
142. ENERGY AND MACRONUTRIENT
METABOLISM RIS BUSINESS MEETING
AND HOT TOPICS SEMINAR
Minisymposium
RIS Forum
(Sponsored by: Energy and Macronutrient
Metabolism RIS)
Sun. 3:00 pm—San Diego Convention Center, Room 33BC
Chaired: V.J. Vieira-Potter
143. EXPERIMENTAL ANIMAL NUTRITION
RIS BUSINESS MEETING AND HOT
TOPIC PRESENTATION
RIS Forum
Chaired: K.M. Ajuwon
144. TRANSDISCIPLINARY TRAINING IN
CHILDHOOD OBESITY PREVENTION:
APPROACHES, SUCCESSES
AND CHALLENGES
Symposium
Chaired: S.M. Donovan
Cochaired: G.L. Jensen
Nutrition Across the Lifespan: From Pediatrics
to Geriatrics
Education
3:00Illinois
Transdisciplinary
Obesity
Prevention
Program (I-TOPP). S. Donovan. Univ. of Illinois
at Urbana-Champaign.
3:20 Childhood Obesity Prevention Training (COPT).
B. Rolls. Penn State
3:40 Innovation
and
Collaboration:
Creating
a
Transdisciplinary Childhood Obesity Prevention
(TOP) Graduate Education Certificate Program.
J. Meendering. South Dakota State Univ.
4:00
Sanos Y Fuertes: Creating Culturally Relevant Programs
for the University and Community. B. Rios-Ellis.
California State Univ., Monterey Bay.
4:20
Trainee Perspective – I-TOPP (University of Illinois).
K. Robinson. Univ. of Illinois at Urbana-Champaign.
4:40
Trainee Perspective – COPT (Penn State). S. Kling.
Penn State
5:00
Panel Discussion.
48
145. DBC: METABOLISM AND BIOAVAILABILITY OF
DIETARY BIOACTIVE COMPONENTS
Chaired: R. Bruno
Cochaired: S. Sang
3:00 145.1
Biotransformation of 5-Demethyltangeretin
in Mice: Generation of Anti-cancer Metabolites. X. Wu,
Y. Sun, M. Wang, Z. Gao, M. Song, H. Xiao. Univ. of
3:15 145.2
Quantification of Javamide-I and -II in Twelve
Coffee Drinks and Their Effects on Sirtuin1/2/3 Enzymes and
p53-Acetylation in THP-1 Cells. J. Park. USDA, Beltsville, MD.
3:30 145.3
The Metabolic Fate of Isotopically-Labeled
Trimethylamine-N-Oxide in Humans. S. Taesuwan, C.E. Cho,
O.V. Malysheva, E. Bender, J. Yan, A. Thalacker-Mercer, M.A.
Caudill. Cornell Univ.
3:45 145.4
Nutrimetabolomics Fingerprinting to Identify
Biomarkers of Whole Grain Wheat Intake. S. Sang, Y. Zhu, W.
Sha, P. Wang. North Carolina A&T State Univ., Kannapolis and
Univ. of North Carolina at Charlotte.
4:00 145.5
Phenolic Recovery and Bioaccessibility from
Milled and Finished Whole Grain Oat Products. M. Li, K.
Koecher, L. Hansen-TechCenter, M.G. Ferruzzi. Purdue
Univ. and General Mills Inc., MN.
4:15 145.6
Major Furocoumarins in Grapefruit Are
Detectable in Plasma following Consumption of Grapefruit and
Grapefruit Juice. M. Moser, T.M. Vance, T. Mali, S.G. Lee, C.
Perkins, A. Provatas, A. Qureshi, O.K. Chun, E. Cho. Univ. of
Connecticut, North Carolina A&T State Univ. and Warren Alpert
Med. Sch. of Brown Univ.
4:30 145.7
Gastrointestinal
Biotransformation
of
Resveratrol in Mice. F. Li, Y. Sun, M. Song, X. Wu, H. Xiao.
Univ. of Massachusett Amherst and Sch. of Pharm., Ocean
Univ. of China.
4:45 145.8
Plasma Plant Sterol and Plant Sterol Intake
in Plant-Based Diets. K. Jaceldo-Siegl, D. Lütjohann, R.
Sirirat, E. Haddad. Loma Linda Univ. and Univ. Clins. of
Bonn, Germany.
146. OBESITY: OBESITY, GUT MICROBIOME
AND MACRONUTRIENTS
Minisymposium
Chaired: F. Greenway
3:00 146.1
Soy Positively Impacts Cecal Microbiota
of Ovariectomized Rats Selectively Bred for Low Aerobic
Capacity. T-W. Liu, T.M. Zidon, R.J. Welly, Y-M. Park, S.L.
Britton, L.G. Koch, J. Padilla, V.J. Vieira-Potter, K.S.
Swanson. Univ. of Illinois, Urbana, Univ. of Missour-Columbiai
and Univ. of Michigan.
SUNDAYNUTRITION
3:15 146.2
Associations between Physical Activity and
the Intestinal Microbiome of College Freshmen. C.M. Whisner,
M. Bruening. Sch. of Nutr. and Hlth. Promotion, Arizona
State Univ.
3:30 146.3
Gut Microbiota Metabolites in Infancy:
Associations with Breastfeeding and Childhood Overweight.
S. Bridgman, P. Koleva, R. Mandal, M. Azad, C. Field, A.
Haqq, A. Becker, S. Turvey, P. Mandhane, P. Subbarao,
M. Sears, D. Wishart, A. Kozyrskyj. Univ. of Alberta, Univ.
of Manitoba, Univ. of British Columbia, Univ. of Toronto and
McMaster Univ., Canada.
3:45 146.4
Relationship between Human Gut Microbiota
and Interleukin 6 Levels in Overweight and Obese Adults.
D. Cooper, E.B. Kim, M. Marco, B. Rust, L. Welch, W. Horn,
R. Martin, N. Keim. Univ. of California, Davis, USDA, Davis
and Seoul Natl. Univ.
4:00 146.5
Depressive Like Behavior and Changes in the
Gut Microflora Are associated with a High Fat Diet in Male
Sprague Dawley Rats. G. Chompre, M.L. Cruz, S. Cruz, Y.
Yamamura, C. Appleyard. Pontifical Catholic Univ. of Puerto
Rico and Ponce Hlth. Sci. Univ. Med. Sch. & Ponce Res. Inst.
4:15 146.6
Obesity-Prone High-Fat Fed Rats Reduce
Caloric Intake and Adiposity and Gain More Fat-Free Mass When
Allowed to Separate Protein from Carbohydrate/Fat Intake. D.
Tomé, D. Azzout-Marniche, T. Chalvon-Demersay, G. Pimentel,
C. Chaumontet, N. Nadkarni, J. Piedcoq, G. Fromentin, C.
Gaudichon, P.C. Even. AgroParisTech, INRA, Univ.Paris Saclay.
4:30 146.7
Impact of Free-Living Nutrition Intervention
on Microbiome in College Students at Risk for Disease:
FRUVEDomic Pilot Study. O.A. Famodu, C.F. Cuff, A.
Cockburn, M.T. Downes, P.J. Murray, J.W. McFadden, S.E.
Colby, J.S. Morrell, I.M. Olfert, M.D. Olfert. West Virginia Univ.,
Univ. of Tennessee, Knoxville and Univ. of New Hampshire.
4:45 146.8
Effects of an Almond-Enriched Energy Restricted
Diet on Body Composition, Visceral Adipose Tissue and Blood
Pressure in Obese Adults. J. Dhillon, R. Mattes. Purdue Univ.
147. DIET AND CANCER: ANIMAL AND
MOLECULAR STUDIES
Minisymposium
(Sponsored by: Diet and Cancer RIS)
Chaired: J-R. Zhou
Cochaired: S. Wang
3:00 147.1
Dietary Tomato Reduces Castration-Resistant
Prostate Cancer Burden in the TRAMP Model. J.W. Smith, J.L.
Rowles III, R.J. Miller, S.K. Clinton, W.D. O’Brien; Jr., J.W.
Erdman; Jr. Univ. of Illinois at Urbana-Champaign and The
Ohio State Univ.
3:15 147.2
The Effect of Oil Palm Phenolics on Pancreatic
Ductal Adenocarcinoma in Transgenic Mouse Model.
N.H. Razalli, P. Gowthaman, N. Saadat, S. Vemuri, A. Goja,
R. Sambanthamurthi, S.V. Gupta. Wayne State Univ. and
Malaysian Palm Oil Bd., Kajang.
3:30 147.3
Dried Plums Modify Fecal Short Chain Fatty
Acid Concentrations and Gene Expression in a Rat Model of
Colon Carcinogenesis. D.V. Seidel, K.K. Hicks, S.S. Taddeo,
M.A. Azcarate-Peril, R.J. Carroll, N.D. Turner. Texas A&M
Univ. and Univ. of North Carolina at Chapel Hill.
3:45 147.4
Apiaceous and Cruciferous Vegetables Fed in
the Post-initiation Stage Reduce Colonic Precancerous Lesions
and the Cancer Stem Cell Marker DCLK1, and Alter the miRNA
Expression Profile in 1,2-Dimethylhydrazine-Treated Rats.
S. Kim, S.P. Trudo, D.D. Gallaher. Univ. of Minnesota, St. Paul
and Univ. of Arkansas Sch. of Human Envrn. Sci.
4:00 147.5
Through Metabolic Reprogramming Walnut
May Mitigate the Stemness of Colon Cancer Stem Cells.
S.W. Choi, J. Choi, J. Kim, S. Friso, Y. Kim. CHA Univ.,South
Korea, Univ. of Verona Sch. of Med. and Ewha Womans Univ.,
South Korea.
4:15 147.6
The Role of Intra-abdominal Adipose Tissue in
Cancer. J. Bernard, B. Bullard. Michigan State Univ.
4:30 147.7
Microenvironment Folate Stress Promotes
Warburg-Metabolic Switched-Cancer Stem Cell Signaling
Network and Stemness Features to Mediate Invasion and
Metastasis of Lung Cancers. W-J. Chen, R-F.S. Huang. FuJen Catholic Univ., Taiwan.
4:45 147.8
Cranberry Extract Initiates Intrinsic Apoptosis
in HL-60 Cells by Increasing Bad Activity through the Inhibition
of Akt Phosphorylation. R. Mansouri, S.S. Percival. Univ.
of Florida.
148. VITMIN: ZINC AND SELENIUM
Minisymposium
Chaired: A. Grider
Cochaired: D. Ekoue
3:00 148.1
Zinc-Induced Upregulation of Metallothionein2A Is Predicted by Gene Expression of Zinc Transporters
in Healthy Adults. A. Chu, M. Foster, S. Ward, K. Zaman,
D. Hancock, P. Petocz, S. Samman. Univ. of Otago, New
Zealand, Univ. of Sydney and Macqurie Univ., Australia.
3:15 148.2
Zinc and ZIP14 (Slc39a14) Are Required
for Adaptation to ER Stress in Mouse Liver. M-H. Kim, T.B.
Aydemir, R.J. Cousins. Univ. of Florida.
3:30 148.3
Chronic Zinc Deficiency Alters Chick (Gallus
gallus) Gut Microbiota Structure and Function. E. Tako, O. Koren.
USDA, Cornell Univ. and Fac. of Med., Bar-Ilan Univ., Israel.
3:45 148.4
Serum Zinc and Hemoglobin Concentrations
in Persons with Human Immunodeficiency Virus Infection: The
Positive Living with HIV Study. K. Poudel-Tandukar. Univ. of
4:00 148.5
Novel Role of Glutathione Peroxidase-1 in
Liver and Muscle Protein Metabolism of Mice. L. Tao, Z.P.
Zhao, X.G. Lei. Cornell Univ.
4:15 148.6
Removal of Glutathione Peroxidase 4 in Mouse
Liver Leads to Early Lethality and Vitamin E Can Compensate
for Its Loss. B.A. Carlson, R. Tobe, E. Yefremova, P.A. Tsuji,
V.J. Hoffmann, U. Schweizer, V.N. Gladyshev, D.L. Hatfield,
M. Conrad. NCI, NIH, Ritsumeikan Univ., Japan, Helmholtz
Ctr. Munich, Towson Univ., OD, NIH, Rheinische FriedrichWilhelms-Univ. Bonn and Harvard Med. Sch.
4:30 148.7
Selenium (Se) Homeostasis in Chicken Central
Nervous System Involves Selenoprotein Expression from
Insufficient to Excess Se. J. Li, X. Jiang, C. Cao, C. Zhang, X.
Li, W. Li. Col. of Vet. Med., Northeast Agr. Univ., China.
49
S
U
N
NUTRITIONSUNDAY
4:45 148.8
Soy Protein Diet Preserves Skilled Ladder
Rung Walking Performance after Stroke Better Than
Isoflavones Alone in Adult and Aged Male Rats. R.A. Sunde,
R.M. Taylor, J-L. Li. Univ. of Wisconsin-Madison and Northeast
Agr. Univ., China.
FOOD SECURITY AND ITS CONNECTIONS TO
NUTRITION AND HEALTH SECTION I
Minisymposium
Nutrition RIS)
Chaired: H.A. Eicher-Miller
Cochaired: L. Cordeiro
3:00 149.1
Differential Associations of Food Insecurity
Risk on Dietary Intake-Frequency among Parents and Their
Adolescent Children. E. Calloway, T. Smith, C. Pinard, A. Oh,
L. Nebeling, E. Hennessy, A. Yaroch. Gretchen Swanson Ctr.
for Nutr., Omaha and NCI, NIH.
3:15 149.2
Women’s Empowerment and Food Security
Status: A Global Comparative Study of Women Living in
Rural and Urban Areas. K. Sinclair, D. Ahmadigheidari,
D. Dallmann, H. Melgar-Quiñonez. McGill Univ., Ste. Anne de
Bellevue, QC.
3:30 149.3
Altered Daily Activities and Shame Resulting
from Children Experiencing Food Insecurity in Rural South
Carolina and Oregon. E.A. Frongillo, J. Bernal, E. Adams,
E. Massey, T. Rosemond, C.E. Blake. Univ. of South Carolina,
Univ. Simón Bolívar, Caracas and Oregon Hlth. & Sci. Univ.
3:45 149.4
Marginal Food Insecurity Is Associated
with Increased Sodium and Decreased Fruit Consumption
in Mothers and Toddlers from Low-Income Households.
M. Spiker, K. Hurley, Y. Wang, R. Arbaiza, M. Black. Johns
Hopkins Bloomberg Sch. of Publ. Hlth. and Univ. of Maryland
Sch. of Med.
4:00 149.5
The Role of Television during Family Meals:
Enable or Disrupter of Communication. C.E. Blake, T.N.
Rosemond, J. Bernal, E.A. Frongillo. Univ. of South Carolina
and Univ. Simón Bolívar.
4:15 149.6
Strong Interpersonal Relationships Buffer
the Impact of Chaos on Quality of Family Meal Interactions
in Food-Insecure Households. T.N. Rosemond, C. Blake, J.
Bernal, M.P. Burke, E.A. Frongillo. Univ. of South Carolina,
Univ. Simon Bolivar, Venezuela and USDA, Alexandria, VA.
4:30 149.7
Food Insecurity’s Association with Gestational
Weight Gain Varies by Pre-pregnancy Weight and Parity.
E. Metallinos-Katsaras, E. Siu, R. Colchamiro. Simmons
Col. and Massachusetts Department of Publ. Hlth., Boston.
4:45 149.8
High Household Food Insecurity Impacts
Dietary Patterns in Rural and Urban American Indian Families
with Young Children. E. Tomayko, K. Mosso, K. Cronin, R.
Prince, A. Adams. Univ. of Wisconsin-Madison.
50
150. GLOBAL NUTRITION: IMPACT OF NUTRITIONAL
SUPPLEMENTATION AND PREDICTORS
OF ADHERENCE
Minisymposium
Chaired: L.M. Neufeld
Cochaired: S. Young
3:00 150.1
Maternal Lipid-Based Nutrient Supplements
Did Not Reduce Depressive Symptoms during Pregnancy
and Lactation in Rural Bangladesh. S.L. Matias, M.K. Mridha,
S.A. Khan, S. Hussain, Z. Siddiqui, S. Vosti, C.D. Arnold,
K.G. Dewey. Univ. of California, Davis, ICDDR and Save the
Children, Dhaka, Bangladesh.
3:15 150.2
Individual and Structural Environmental
Influences on Utilization of Iron and Folic Acid Supplementation
among Pregnant Women in Harare, Zimbabwe. C.B. Tinago,
L. Annang Ingram, C.E. Blake, E.A. Frongillo. Univ. of
South Carolina.
3:30 150.3
Social
Support
Enhances
Adherence
to Antenatal Calcium and Iron-Folic Acid Supplements:
Acceptability and Impact of Adherence Partners. S. Martin, M.
Omotayo, R. Stoltzfus, K. Dickin. Cornell Univ.
3:45 150.4
High Prevalence of Low Urinary Iodine among
Pregnant and Lactating Women of Bangladesh Does Not
Respond to Daily Lipid-Based Nutrient Supplement Containing
250 µg Iodine. M.K. Mridha, S.L. Matias, S.A. Khan, R.R.
Paul, Z. Siddiqui, B. Ullah, S. Hussain, R.T. Young, C.D.
Arnold, K.G. Dewey. Univ. of California, Davis, ICDDR,B, Care
Bangladesh and Save the Children, Dhaka, Bangladesh.
4:00 150.5. Physical Activity and Work Productivity in
Response to Iron and Iodine Double-Fortified Salt Trial in
Indian Tea Estate Workers. M.M. Blakstad, J.E.H. Nevins,
S. Venkatramanan, E.M. Przybyszewski, J.D. Haas. Cornell
Univ. and McGill Univ., Ste. Anne de Bellevue.
4:15 150.6
Are We Done? Predicting the Impact of
Supplement Use and Mandatory and Voluntary Folic Acid
Fortification on the Risk of Neural Tube Defects in the United
States. K.S. Crider, O. Devine, Y.P. Qi, S.C. Tinker, R.J. Berry.
Ctrs. for Dis. Control and Prevent. and Cater Consulting, Atlanta.
4:30 150.7
Effect of Short-Term Maternal Supplementation
with Small Amounts of Vitamin A or Beta-Carotene on Breast
Milk Retinol Concentrations among Lactating Filipino Women.
R. Engle-Stone, A. Osei, M.F.D. Reario, A. Hall, J.E.
Arsenault, N. Haselow, G. Lietz, K.H. Brown, M.J. Haskell.
Univ. of California, Davis, Helen Keller Intl., NY, Newcastle
Univ., U.K. and Bill & Melinda Gates Fndn., Seattle.
4:45 150.8
A Comprehensive Nutrition Program Improved
Nutritional Status among Children Aged 6 to <24 Months in
Rural Malawi. Y. Kang, K. Hurley, A.B. Monclus, J. RuelBergeron, R. Oemcke, L.S.F. Wu, M. Mitra, J. Phuka, P.
Christian. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and
Col. of Med., Univ. of Malawi.
SUNDAYNUTRITION
151. MATERNAL, PERINATAL AND PEDIATRIC:
MEETING THE NUTRITIONAL NEEDS OF
PEDIATRIC POPULATIONS
152. NUTRITION EDUCATION: DEVELOPING
HEALTHY EATING AND PHYSICAL ACTIVITY
BEHAVIORS ACROSS THE LIFESPAN
Minisymposium
Minisymposium
Maternal, Perinatal and Pediatric RIS
(Sponsored by: Nutrition Education and Behavioral
Science RIS)
Chaired: B. Olson
Cochaired: J.T. Smilowitz
3:00 151.1
Choline Intake during Pregnancy and Genetic
Polymorphisms Influence Choline Metabolism in Chinese
Preterms Receiving Total Parenteral Nutrition Therapy. J. Zhu.
Sch. of Med., Shanghai Jiao Tong Univ.
3:15 151.2
Early Weight Gain, Linear Growth, and Midchildhood Blood Pressure. W. Perng, S.L. Rifas-Shiman, M.S.
Kramer, L.K. Haugaard, E. Oken, M.W. Gillman, M.B. Belfort.
Univ. of Michigan Sch. of Publ. Hlth., Harvard Med. Sch./
Harvard Pilgrim Hlth. Care Inst., McGill Univ. Fac. of Med.,
Univ. of Copenhagen, Bispebjerg and Frederiksberg Hosps.,
Copenhagen, Harvard Sch. of Publ. Hlth. and Brigham and
Women’s Hosp.
3:30 151.3
Lean Mass Accretion Associates with Vitamin
D Intake: A 6 Month Randomized Controlled Trial in 2-8 Year
Olds Using Fortified Foods. N.R. Brett, C.A. Parks, P. Lavery,
S. Agellon, C.A. Vanstone, J.L. Maguire, F. Rauch, H.A.
Weiler. Sch. of Dietetics and Human Nutr., McGill Univ., Li Ka
Shing Inst. of St. Michael’s Hosp., Univ. of Toronto and Shriners
Hosp. for Children, McGill Univ.
3:45 151.4
Erythrocyte
Omega-3
Long
Chain
Polyunsaturated Fatty Acids Are Associated with Lumbar Spine
but Not Whole Body Bone Mineral Density in Healthy Children.
C.A. Parks, N.R. Brett, S. Agellon, P. Lavery, C.A. Vanstone,
J.L. Maguire, F. Rauch, H.A. Weiler. Sch. of Dietetics and
Human Nutr., McGill Univ., Li Ka Shing Knowledge Inst. of St.
Michael’s Hosp., Univ. of Toronto and McGill Univ., Montreal.
4:00 151.5
Standing by Human Milk through Thick and
Thin: The Effect of Thickeners on Human Milk Viscosity.
J.K. Koo, L. Bode, J.H. Kim. UCSD/Rady Children’s Hosp. of
San Diego.
4:15 151.6
Maternal Plasma Folate, Vitamin B12 Levels
and Multivitamin Supplementation during Pregnancy and
Risk of Autism Spectrum Disorder in the Boston Birth Cohort.
R. Raghavan, M.D. Fallin, X. Wang. Johns Hopkins Bloomberg
Sch. of Publ. Hlth.
4:30 151.7
Novel Tool for Discrimination of Feeding
Intolerance and Necrotizing Enterocolitis Risk in the Preterm
Infant. J. Naberhuis, C. Wetzel, K. Tappenden. Baylor Col. of
Med., USDA, Houston, Carle Fndn. Hosp., Urbana and Univ. of
Illinois at Urbana-Champaign.
4:45 151.8
Dietary Intakes of Formula-Fed Infants
Consuming a Meat- or Dairy-Based Complementary Diet:
A Semi-controlled Feeding Trial. M. Tang, K.E. Griese, N.F.
Krebs. Univ. of Colorado Anschutz Med. Campus.
Chaired: R. Scherr
Cochaired: J.L. Kaar
3:00 152.1
Nutrition Messages in Picture Book Fiction for 4
to 8 Year Old Children. O.A. Matvienko. Univ. of Northern Iowa.
3:15 152.2
Perceived Barriers to Physical Activity during
Pregnancy among Participants of the Special Supplemental
Nutrition Program for Women, Infants and Children in Southern
California. M. Koleilat, N. Vargas, G. Kodjebacheva. California
State Univ., Fullerton and Univ. of Michigan-Flint.
3:30 152.3
Behavioral and Sociodemographic Correlates
of Overall Diet Quality Over 4 Years in a National Cohort of
U.S. Emerging Adults. L.M. Lipsky, T.R. Nansel, D. Haynie, D.
Liu, K. Li, C. Pratt, R.J. Iannotti, B. Simons-Morton. NICHD,
NIH, Col.. of Hlth. and Human Sci., Colorado State Univ.,
NHLBI, NIH and CDM Gp., Bethesda.
3:45 152.4
Does Healthcare Provider Advice Matter for
Gestational Weight Gain? N.P. Deputy, A.J. Sharma, S.Y.
Kim. Emory Univ. and Ctrs. for Dis. Control and Prevent.
4:00 152.5
No Time for Family Meals – What’s a Family to
Do? A.W. Watts, J. Berge, K. Loth, N. Larson, D. NeumarkSztainer. Univ. of Minnesota, Minneapolis.
4:15 152.6
If You’re Happy and You Know It: Associations
between Emotion, Social Context, and Food Choices in College
Freshmen. J. Ashurst, I. van Woerden, M. Bruening. Arizona
State Univ.
4:30 152.7
Physical Activity Level, Modeling, and
Importance to Mothers of Preschool Children. J.T. MartinBiggers, V. Quick, J. Worobey, C. Byrd-Bredbenner.
Rutgers Univ.
4:45 152.8
Perceptions on Weight Management for
Survivors of Pediatric ALL from Parents and Pediatric Oncology
Professionals: A Mixed Methods Study. W. Chang, S. Folta, R.
Hill, M. Kelly, S. Meagher, E. Danahy, P. Bowman, F.F. Zhang.
Tufts Univ., Boston, Smith Col., Cook Children’s Med. Ctr., Fort
Worth and Tufts Med. Ctr.
51
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NUTRITIONSUNDAY
153. INTERNATIONAL FORUM – KOREA: HEALTH
AND FUNCTIONAL FOODS: WHERE WE ARE
AND WHERE WE GO
(Organized and Sponsored by: The Korean Nutrition Society)
An interest on health and functional foods is rapidly emerging
along with expanding elderly populations. This session will review
progress in the field of health and functional foods and share
current knowledge on the mechanisms of actions on specifically
chosen bioactive components in the aspects of gut, liver and
adipose tissue health with Korean researchers working in both
Korea and USA.
Sun. 3:00 pm—San Diego Convention Center, Room 28DE
3:00
International Forum
Chaired: Y-S. Cha
Cochaired: Y. Park
Effect of Sasa Quelpaertensis Leaf Extracts on Intestinal
Inflammation and Colon Cancer Stemness. Y. Kim.
Ewha Womans Univ.
3:25
Role of Piceatannol in Adipose Lipolysis and Obesity.
K-H. Kim. Purdue Univ.
3:50
A Novel Role of Astaxanthin in the Modulation of Histone
Deacetylase 9 for the Prevention of Liver Fibrosis.
J-Y. Lee. Univ. of Connecticut.
4:15Discussion.
Are You Tweeting about EB 2016?
Be sure to follow EB on Facebook
52
and Twitter.
SUNDAYPATHOLOGY
Pathology
154. COMMITTEE FOR CAREER DEVELOPMENT
AND DIVERSITY WORKSHOP AND BREAKFAST:
CAREER-CHOICE OPPORTUNITIES IN SCIENCE
156. HCS SYMPOSIUM: THE 3D BRAIN: FROM
DIFFUSION MRI TO ULTRASTRUCTURE
Symposium
Workshop
(Sponsored by: the ASIP Immunohistochemistry
& Microscopy Scientific Interest Group and The
Histochemical Society )
(Sponsored by: the ASIP Committee for Career
Development & Diversity )
Sun. 7:00 am—San Diego Marriott Marquis & Marina
Hotel, Temecula
Chaired: C. Kolarcik
Cochaired: M. Barroso
Cochaired: J. Arboleda-Velasquez
Neurobiology
Career Development
7:00Introduction. C. Kolarcik. Univ. of Pittsburgh.
7:10
Molecular Diagnostics/Clinical Chemistry. G. Tsongalis.
Dartmouth-Hitchcock Med. Ctr.
7:30 Scientific Publishing. A. Cox. The American Journal
of Pathology.
7:50 Science Administration (Non-profits, Government,
For-profits). M. Sobel. American Society for
Investigative Pathology.
8:10
Science Public Policy. Y. Seger. Federation of American
Societies for Experimental Biology.
8:30Technology/Entrepreneur/Start-Ups. C. Parkos. Univ.
of Michigan.
8:50
Closing Remarks. J. Arboleda-Velasquez. Schepens
Eye Research Inst.
155. AMERICAN SOCIETY FOR MATRIX
BIOLOGY LECTURE
Lecture
(Sponsored by: ASIP and the American Society for
Matrix Biology)
Neuropathology
8:30
9:30
Diffusion MRI of the Brain Connectome: Problems and
Possibilities. V. Wedeen. Harvard Univ.
High-resolution Structural and Molecular Imaging of the
Brain. K. Chung. MIT.
157. JOURNAL OF HISTOCHEMISTRY &
CYTOCHEMISTRY LECTURE
Lecture
Chaired: S. Hewitt
10:30 Multiscale Optical Imaging of the Living Brain.
E. Hillman. Columbia Univ.
158. SCVP SYMPOSIUM: CYTOKINE SIGNALING IN
THE HEART
Symposium
Cancer Biology
8:30
S
U
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Chaired: D. Rosene
Matrix Pathobiology
(Sponsored by: ASIP and the Society for Cardiovascular
Pathology )
Neoplasia
Chaired: J.R. Stone
The Matricellular Protein Thrombospondin 1 in the
Myeloma Microenvironment. J. Murphy-Ullrich. Univ.
of Alabama at Birmingham.
Cochaired: J. Homeister
Cardiac Pathobiology
Cell and Tissue Injury
8:30
9:15
10:00
The Role of Cardiac Innate Immunity in Cardiac Injury.
M. Willis. Univ. of North Carolina at Chapel Hill.
The Role of TGF-beta Signaling in Cardiac Remodeling.
N. Frangogiannis. Albert Einstein Med. Ctr.
NLRP3 in Inflammasome Inhibition in Acute Myocardial
Injury. S.Toldo. Virginia Commonwealth Univ.
Med. Ctr.
53
PATHOLOGYSUNDAY
10:45
Inflammatory Cytokines Induce a Novel Cardioprotective
Zing Finger Protein, MCPIP. P. Kolattukudy. Univ. of
Central Florida.
159. LIVER PATHOBIOLOGY WORKSHOP:
LIVER INJURY, INFLAMMATION, AND
TUMORIGENESIS: IMPLICATIONS IN CANCER
PREVENTION AND TREATMENT
10:30 160.5
Surface Topography during Neural Stem Cell
Differentiation Regulates Cell Migration and Cell Morphology.
C. Czeisler, A. Short, B. Stocker, J. Cronin, J. Lannutti, J.
Winter, J.J. Otero. The Ohio State Univ.
161. XVITH ANNUAL ASIP/AAA CAREER
DEVELOPMENT AND MENTORING PROGRAM
AND LUNCH: HOW TO NETWORK EFFICIENTLY
AND CHOOSE A CAREER PATH
Workshop
Special Session
(Supported by an unrestricted educational grant from
Elsevier)
(Sponsored by: the ASIP Committee for Career
Development & Diversity and the American Association
of Anatomists)
Chaired: S.P.S. Monga
Cochaired: X. Chen
Hotel, Presidio 1
Cancer Biology
Chaired: D. Bielenberg
Liver Pathobiology
Cochaired: J. Jones-Triche
Neoplasia
Career Development
8:30
9:00
9:30
Hepatic Ploidy. A. Duncan. Univ. of Pittsburgh.
Hepatic Fibrosis and Cancer. B. Schnabl. UCSD.
FXR/HNF4a and Cancer. U. Apte. Univ. of Kansas
Med. Ctr.
10:00 Progenitors and Cancer. E. Seki. UCSD.
10:30 Modeling Human HCC in MIce. S.P. Monga. Univ.
of Pittsburgh.
11:00Cholangiocarcinoma. T. Wu. Tulane Univ. Hlth. Sci.s Ctr.
160. EXTRACELLULAR MATRIX
Minisymposium
Chaired: W. Stetler-Stevenson - Junior Faculty
Cochaired: R. Iozzo
Matrix Pathobiology
Neoplasia
9:30 160.1
Twist1
Phosphorylation
Contributes
to
Pulmonary Fibrosis through Angiopoietin-Tie2 Signaling.
A. Mammoto, A. Jiang, E. Jiang, T. Mammoto. Boston
Children’s Hosp.
9:45 160.2
Extracellular Vesicles Isolated from Human
Mesenchymal Stem Cells Promote Resolution of Pulmonary
Fibrosis. T.P. Shentu, S. Wong, C. Espinoza, M. CernelcKohan, J. Hagood. UCSD and Rady Hosp. of San Diego.
10:00 160.3
Matrix
Metalloproteinase-28
Activates
Signal Transducer and Activator of Transcription 1 to Induce
Macrophage M1 Polarization. M.L. Lindsey, P.L. Cannon, E.R.
Flynn, M. Jung, R.P. Iyer, K.Y. DeLeon-Pennell, Y. Ma. Univ.
of Mississippi Med. Ctr.
10:15 160.4
Stromal Cell-Derived Extracellular Matrix
Stimulates Mesenchymal Stem Cell Proliferation and SSEA4
Expression When Used as Supplement in Cell Growth Medium.
R. Zamilpa, I. Flores, M.M. Navarro, S. Griffey. StemBioSys
Inc. and Univ. of Texas Hlth. Sci. Ctr. at San Antonio.
54
11:45Introduction. D. Bielenberg. Harvard Med. Sch.,
Children’s Hosp.
11:50 Tips and Tools for Effective Networking. L. McManus.
Univ. of Texas Hlth. Sci. Ctr.
12:10 Speed Networking Format. J. Jones-Triche. Univ.
of Michigan.
Speed Networking
12:15
Table 1: Technology/Entrepreneur/Start-Ups. C. Parkos.
Univ. of Michigan Med. Sch.
12:15 Table 2: Scientific Editor. A. Cox. ASIP.
12:15 Table 3: Science Administration. M. Sobel. ASIP.
12:15 Table 4: Public Policy. Y. Seger. FASEB Publ. Affairs.
12:15 Table 5: Molecular Diagnostics/Clinical Chemistry.
G. Tsongalis. Dartmouth Med. Sch.
12:15 Table 6: Scientific Consulting. C. Yates. Univ.
of Pittsburgh.
12:15 Table 7: Biotechnology. C. Austin, S. Pirie-Shephard.
Genentech, Pfizer.
12:15 Table 8: Government Positions. E. Unger. CDC.
12:15 Table 9: Teaching/Academic Administration. V. Holloway.
DeVry, Inc.
162. HOST PATHOGEN INTERACTIONS
Symposium
Chaired: D.A. Milner, Jr.
Cochaired: A. Nusrat
Epithelial and Mucosal Pathobiology
Microbiome
Immunopathology
2:00Bacteria. A. Neish. Emory Univ.
2:45Bacteria. P. Dorrestein. UCSD.
3:30Virus. K. Cadwell. NYU Sch. of Med.
SUNDAYPATHOLOGY
4:15 162.1
Giardia duodenalis Directly Depletes Mucins
in Intestinal Goblet Cells. C.B. Amat, J-P. Motta, K. Chadee,
A.G. Buret. Univ. of Calgary, Canada.
163. MOLECULAR AND CELLULAR FOUNDATIONS
OF GLIAL ONCOGENESIS: HINTS FOR
PREVENTION AND THERAPY
Symposium
Chaired: W. Tourtellotte
Cochaired: E. Whitley
Neurobiology
Neuropathology
Neoplasia
2:00
Hide and Seek: A Surprising Role for Extrachromosomal
EGFR Mutations in Glioblastoma Pathogenesis.
P. Mischel. UCSD.
2:45 Neuronal
Activity
Promotes
Glioma
Growth.
H. Venkatesh. Stanford Sch. of Med.
3:30 Targeting Developmental Pathways in Glioblastoma.
S. Kesari. UCSD.
4:15
Therapeutic Hypothesis Testing With Patient Derived
Brain Tumor Xenograft Models. C. James.
Northwestern Univ. Feinberg Sch. of Med.
164. CELL INJURY WORKSHOP: PROTEOTOXICITY
AND CELL INJURY
Workshop
165. ENDOTHELIAL CELL BIOLOGY
Minisymposium
(Sponsored by: the ASIP Cell Injury Scientific
Interest Group)
Chaired: R. Mitchell
Cochaired: A. Adam
Chaired: M. Willis
Vascular Biology
Cochaired: C.C. Yates
Neuropathology
2:00
Charleston. (57.10)
Th1 Effector T Cells Induce Cardiac Fibroblasts
Transition to Myofibroblasts and Contribute to Pressure
Overload-Induced Cardiac Fibrosis. T. Nevers, A.M.
Salvador, F. Velazquez, M. Aronovitz, R. Blanton, P.
Alcaide. Tufts Med. Ctr. and Tufts Univ. (306.7)
4:10Dimethyl
Fumarate
Ameliorates
Pulmonary
Hypertension In Vivo and Prevents Fibrosis via
βTRCP-Mediated Degradation of β-Catenin and TAZ.
A. Grzegorzewska, R. Han, F. Seta, L. Stawski, C.
Feghali-Bostwick, J. Browning, M. Trojanowska.
Boston Univ. and Med. Univ. of South Carolina. (50.2)
4:20
Mechanisms Underlying the Induction of a Profibrotic
Epithelial Phenotype during Renal Fibrosis. J. Folke
Bialik, M. Rozycki, P. Speight, Z.M. Miranda, S.G.
Szeto, D.A. Yuen, Q. Dan, K. Szászi, S.F. Pedersen,
A. Kapus. St. Michael’s Hosp., Toronto, Univ. of
Copenhagen and Univ. of Toronto. (445.6)
4:30
Absence of Mast Cells in an Experimental Model of
Pulmonary and Cardiac Fibrosis, the CUX-1 Mice.
N.A. Reddy, F. Raza, A. Said, S. Livingston, D.
Jacobsen, D. Kearns, R. Baybutt, G. Van Den
Heuvel, A. Molteni, S. Hamidpour. Univ. of Missouri
Kansas City, Wheaton Col., IL and Western Michigan
Univ. (50.10)
4:40
TMPRSS4: A Novel Serine Protease Involved in IPF
Development? A.M. Valero, J. Cisneros, R. Ramírez,
M. Gaxiola, C. Becerril, A. Pardo, M. Selman. Fac.
of Sci, Natl. Autonomous Univ. of Mexico and INER,
Mexico City. (50.8)
4:00
Proteotoxicity and Cell Injury. M. Willis. Univ. of North
Carolina at Chapel Hill.
2:10
The Interplay Between Autophagy and the UbiquitinProteasome System in Cardiac Proteotoxicity.
X. Wang. Univ. of South Dakota.
2:40
Role of Amylin in Neuron Proteotoxicity. F. Despa. Univ.
of Kentucky.
3:10 Proteotoxicity and the Role of the Unfolded Protein
Response. L. Wiseman. The Scripps Res. Inst.
3:40
Inhibiting Cardiac Fibrosis in Myocardial Infarction by
CXCL10 Agonist Peptide. L. Espinoza, J. Jaynes,
R. Bodnar, M.S. Willis, C.C. Yates. St. Mary’s Univ.,
TX, Tuskegee Univ., Univ. of Pittsburgh Sch. of Med.,
Univ. of North Carolina at Chapel Hill Sch. of Med.
and Univ. of Pittsburgh Sch. of Nursing. (1178.1)
3:50 FPR1 and Activation of Intestinal Fibroblasts.
T.A. Reaves, M. Anderson-Thomas, A. Nillas, M.
Lecher. Med. Univ. of South Carolina and Col. of
2:00 165.1
Knockdown of Mechanosensitive miRNA
Cluster—miR-106b~25 Decreases Endothelial Proliferation
and Prevents Atherosclerosis in ApoE-/- Mice. S. Kumar, H. Jo.
Emory Univ.
2:15 165.2
Dietary
Nitrate
Supresses
Leukocyte
Recruitment and Activation in Apolipoprotein E Knockout Mice.
R.S. Khambata, S.M. Ghosh, K.S. Rathod, T. Thevathasan,
A. Ahluwalia. Barts and The London Sch. of Med. and Dent.,
Queen Mary Univ. of London.
2:30 165.3
The Critical Role of SENP1-Mediated GATA2
DeSUMOylation in Graft Arteriosclerosis by Promoting
Endothelial Activation. C. Qiu, Y. Wang, X. Zhu, L. Song, H.
Zhang, L. Qin, G. Tellides, W. Min, L. Yu. Zhejiang Univ. Col.
of Life Sci., China and Yale Univ. Sch. of Med.
2:45 165.4
Neuropilin 2 Deficiency Prolongs Skin
Inflammation and Edema. D.R. Bielenberg, P. Mucka,
N. Levonyak, E. Geretti, B.M.M. Zwaans, X. Li, I. Adini,
M. Klagsbrun, R.M. Adam. Harvard Med. Sch., Boston
Children’s Hosp.
3:00 165.5
Sepsis-Associated Proteinase 3 Induces
Endothelial Permeability. E.K. Patterson, G. Cepinskas, K.
Inoue, D.D. Fraser. Lawson Hlth. Res. Inst., London, ON and
Western Univ., Canada.
55
S
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PATHOLOGYSUNDAY
3:15 165.6
STAT3 Regulates Endothelial Permeability
Downstream of the Pro-inflammatory Cytokines IL6 and TNF-α.
H. Alsaffar, N. Martino, P. Vincent, A. Adam, A. Lowery.
Albany Med. Col.
3:30 165.7
Platelets Direct Leukocytes to Their Sites of
Extravasation. G. Zuchtriegel, B. Uhl, D. Puhr-Westerheide,
M. Pörnbacher, K. Lauber, F. Krombach, C.A. Reichel.
Ludwig Maximilian Univ. of Munich.
3:45 165.8
Microvascular Endothelial Cells Can Exhibit
Autophagy In Vivo: Role in Neutrophil Transendothelial Cell
Migration? C.M. Pickworth, R. Beal, N. Reglero, L. Lintermans,
B. Colom, M-B. Voisin, M. Golding, S. Nourshargh. Barts
and The London Sch. of Med. and Dent., Queen Mary Univ.
of London.
4:00 165.9
OxLDL Exerts a Biphasic Effect on Endothelial
Function: A Role for Oxidised Lipids in Angiogenesis and
Inflammation. M. Olding, M.R. Ardern-Jones, E. Healy,
T.M. Millar. Univ. of Southampton.
4:15 165.10 JAM-C Deficiency Primes Endothelial Cells for
a Pro-inflammatory State. N. Reglero, R. Beal, C. Cabrera,
C. Pickworth, M. Golding, J. Whiteford, T. Nightingale, B.
Imhof, M.R. Barnes, S. Nourshargh. Barts and London Sch.
of Med. and Dent., Queen Mary Univ. of London and Ctr. Med.
Univ., Univ. of Geneva.
4:30 165.11 Cell-Type Specific Mechanisms Regulate
Rhythmic Leukocyte Migration to Tissues. W. He, K. Kraus,
D. Druzd, A. de Juan, L. Ince, C-S. Chen, C. Scheiermann.
Ludwig Maximilians Univ., Munich.
4:45 165.12 Leukocytes Exhibit Discrete Rhythms in Their
Recruitment Patterns to Arteries and Veins. A. de Juan, D.
Druzd, G. Zuchtriegel, K. Kraus, C. Reichel, C. Scheiermann.
Walter Brendel Ctr. of Exptl. Med. and Ludwig Maximilians
Univ., Munich.
166. ASIP ROUS-WHIPPLE AWARD LECTURE
Award Lecture
Cancer Biology
Neoplasia
5:00
ASIP Rous-Whipple Award Lecture: The Microscope
as a Tool for Disease Discovery: A Voyage through
the Eyes of a Hematopathologist. E. Jaffe.
Hematopathology Section, Laboratory of Path,
CCR, NCI.
167. THE HISTOCHEMICAL SOCIETY MEMBER
AWARDS PRESENTATION, BUSINESS MEETING
AND RECEPTION
Business Meeting
(Supported by The Histochemical Society)
Hotel, Temecula
Visit the Exhibits
April 3–April 5
Exhibit Hours
Sunday–Tuesday
9:00 AM–4:00 PM
56
SUNDAYPHARMACOLOGY
Pharmacology
168. JULIUS AXELROD AWARD IN PHARMACOLOGY
LECTURE: THERAPIES OF BRAIN DISEASES,
PAST, PRESENT AND FUTURE
170. ADVANCES IN TOXICOGENETICS OF METALS
Symposium
(Sponsored by: The Division for Toxicology)
Award Lecture
(Cosponsored by: The Divisions for Behavioral
Pharmacology, Cancer Pharmacology, and
Molecular Pharmacology)
Sun. 8:30 am—San Diego Convention Center, Room 16AB
Neurobiology
The Julius Axelrod Award is presented annually for significant
contributions to understanding the biochemical mechanisms
underlying the pharmacological actions of drugs and for
contributions to mentoring other pharmacologists. The Award
was established in 1991 to honor the memory of the eminent
American pharmacologist who shaped the fields of neuroscience,
drug metabolism, and biochemistry and who served as a mentor
for numerous eminent pharmacologists around the world.
8:30Introduction.
8:35
Therapies of Brain Diseases, Past, Present and Future.
J. Rossier. Neurosci. Paris Seine.
169. JULIUS AXELROD SYMPOSIUM: NEW
VISTAS ON DRUG AND GENE THERAPIES OF
COGNITIVE DEFICITS IN DOWN SYNDROME,
AUTISM, LEUCODYSTROPHIES AND
ALZHEIMER’S DISEASE
Symposium
S
U
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Cochaired: J. Kim amd T. Maher
Toxicology
Cancer Biology
Neurobiology
9:30
Influence of Brain Iron Overload on Behavioral and
Neurochemical Toxicity. J. Kim. Northeastern Univ.
10:00 Neurobehavioral Effects of Lead (Pb) and Manganese
Individually and in Combination in DevelopmentallyExposed Rats. T. Maher. MCPHS Univ.
10:30 A Novel Molecular Mechanism of Arsenic in Modulating
Autophagy and Nrf2 Stress Responses. D. Zhang.
Univ. of Arizona.
11:00 Mechanisms of Cisplatin Nephrotoxicity. N.S. Pabla.
The Ohio State Univ.
11:30 Ferroportin Deficiency Impairs Manganese Metabolism
in Flatiron Mice. M. Wessling-Resnick. Harvard T.H.
Chan Sch. of Publ. Hlth.
(Supported by the John V. Croker Fund)
Sun. 9:30 am—San Diego Convention Center, Room 16AB
Chaired: J. Rossier
171. NEWLY RECOGNIZED GPCRS IN HEALTH,
DISEASE AND AS THERAPEUTIC TARGETS
Symposium
Neurobiology
9:30
9:40
10:05
10:30
10:55
11:20
11:35
11:50
Comments on the 1986 Seminal Paper: Benzodiazepine
Inverse Agonists Improved Performances in Learning
and Memory Tasks. J. Rossier. Neurosci. Paris Seine.
Treating Cognitive Deficits in a Mouse Model of Down
Syndrome Using GABA-A Alpha 5 Inverse Agonists.
M.C. Potier. Inst. Cerveau et de la Moelle Epinière, Paris.
Alpha 5 Benzodiazepine Inverse Agonists Clinical Studies
for the Treatment of Cognitive Deficits in Down Syndrome
Patients. M. Rafii. Univ. of California, San Diego.
The Diuretic Bumetanide Improves Social Processing in
Individuals with Autism. N. Hadjikhani. Harvard Med.
Sch., Boston.
Gene Therapy Strategy for Alzheimer’s Disease: The
Cholesterol Connection. N. Cartier. INSERM Mircen
CEA, Fontenay-aux-Roses, France.
Correcting Memory Deficits in Fragile X Syndrome by
Targeting Rac1/PAK1 Signaling. L. Martinez, M.V.
Tejada-Simon. Univ. of Houston. (707.8)
Chronic Antagonism of p38α MAPK Normalizes Serotonin
Clearance, Serotonin Receptor Hypersensitivity and
Social Behavior Deficits in a Genetic Murine Model
of Autism Spectrum Disorder. M.J. Robson, M.A.
Quinlan, J. Veenstra-VanderWeele, D.M. Watterson,
R.D. Blakely Vanderbilt Univ., Columbia Univ. and
Northwestern Univ., Chicago. (707.9)
Panel Discussion.
(Sponsored by: The Division for Translational and
Clinical Pharmacology)
(Cosponsored by: The Divisions for Molecular
Pharmacology, Cardiovascular Pharmacology, and
Neuropharmacology )
Cochaired: R. Corriden and P.A. Insel
Translational and Clinical Pharmacology
Cancer Biology
Neurobiology
9:30
GPCRs and the Druggable Genome. B. Roth. Univ. of
North Carolina at Chapel Hill Sch. of Med.
10:00 Chemosensory GPCRs as Targets for Endogenous
Ligands. J. Pluznick. Johns Hopkins Univ. Sch. of Med.
10:30 GPCRs as Regulators of Neutrophil Function.
R. Corriden. UCSD.
11:00 Orphan GPCRs and Psychiatric Disorders: GPR88. B.
Kieffer. McGill Univ.
11:30 The Extent of Vascular Remodeling Is Dependent
on the Balance between ERα and GPER(GPR30).
R. Gros, Q. Ding, Y. Hussain, J. Chorazyczewski,
G. Pickering, R.D. Feldman. Western Univ. and
Memorial Univ. of Newfoundland, Canada. (1189.1)
57
PHARMACOLOGYSUNDAY
11:45
Identification of a First-In-Class Adhesion G ProteinCoupled
Receptor
Orthosteric
Antagonist.
H. Stoveken, A. Smrcka, G.G. Tall. Univ. of Rochester
Med. Ctr. (709.5)
172. DRUGS OF ABUSE AND ANTIRETROVIRALS:
INTERACTIONS AND TOXICITIES
Symposium
(Sponsored by: The Division for Drug Metabolism)
(Cosponsored by: The Divisions for Neuropharmacology,
Toxicology, Pharmacology Education, and
Cochaired: S. Kumar and K. Jordan-Sciutto
10:15 The Role of the Ubiquitin-Proteasome System in
Neurodegenerative Disease. H.L. Paulson. Univ. of
Michigan Hlth. Syst.
10:45 Clinical Development of MDM2 E3 Ligase Antagonists
in Cancer Treatment. G.L. Nichols. Roche Pharma
Res. and Early Develop.
11:15 Targeting Degradation of Regulator of G Protein
Signaling Proteins in Therapeutics. B. Sjogren.
Michigan State Univ.
11:45 Ubiquitin Plays an Atypical Role in GPCR-Induced p38
MAP Kinase Activation on Endosomes. N. Grimsey,
R. Narala, B. Aguilar, C. Rada, T. Smith, A. Soohoo,
M. Puthenveedu, V. Nizet, J.J. Trejo. UCSD. (1266.2)
174. UNDERGRADUATE RESEARCH: CULTIVATING
THE NEXT GENERATION OF RESEARCHERS
THROUGH SURF AND BEYOND
Drug Metabolism
Symposium
Neurobiology
Hotel, San Diego Ballroom B
9:30
Antiretroviral Drugs Induce Oxidative Stress and
Neuronal Damage in the Central Nervous System.
K. Jordan-Sciutto. Univ. of Pennsylvania.
9:55
Drug-Drug Interactions in HIV-Infected Patients Who
Have Other Comorbid Conditions. W. Royal. Univ. of
Maryland Sch. of Med.
10:20 Differential Drug Interactions Between Antiretroviral
Drugs and Methamphetamine in Human and Rhesus
Monkey. A. Kumar. Univ. of Missouri-Kansas City.
10:45 Interactions of HIV and Drugs of Abuse: The Importance
of Glia, Neural Progenitors, and Host Genetic Factors.
P. Knapp. Virginia Commonwealth Univ.
11:10 Drug Interactions and Toxicity between ART and Alcohol
in Monocytes and Astrocytes: Implications with HIV
Pathogenesis. S. Kumar. Univ. of Tennessee Hlth.
Sci. Ctr.
11:35 Tobacco Smoking and HIV Pathogenesis: Potential
Role of Cytochrome P450 Pathway. P.S.S. Rao. Univ.
of Findlay.
173. EMERGING ROLES FOR THE UBIQUITINPROTEASOME SYSTEM IN THERAPEUTICS
Symposium
(Sponsored by: The Division for Drug Discovery
and Development)
Pharmacology, Neuropharmacology, and Cancer
Pharmacology )
Cochaired: B. Sjogren and H.L. Paulson
Drug Discovery and Development
Cancer Biology
Neurobiology
9:30Introduction.
9:35 The Ubiquitin-Proteasome System in Health and
Disease. R. Deshaies. HHMI and Caltech.
58
Cochaired: C. Fry, C.M. Davis and L. Aleksunes
Education
9:30
9:45
Introduction and Overview. C. Fry. ASPET.
Faculty Perspectives on Undergraduate Research:
Strategies, Successes, and Challenges.
S. Tsirka. Stony Brook Univ. Med. Sch.
K. Murnane. Mercer Univ.
L. Aleksunes. Rutgers Univ.
10:30 Student Perspectives on Undergraduate Research:
Benefits, Challenges, and Next Steps.
M. Little. Univ. of North Carolina at Chapel Hill.
C. Fearce. Spelman Col.
N. Arabian. Univ. of Southern California.
11:15 Interactive Table Discussions.
175. GOODMAN AND GILMAN AWARD IN
RECEPTOR PHARMACOLOGY LECTURE
Award Lecture
The Louis S. Goodman and Alfred Gilman Award in
Receptor Pharmacology was established in 1980 to recognize
and stimulate outstanding research in pharmacology of biological
receptors, leading to a better understanding of the mechanisms
of biological processes and providing the basis for the discovery
of drugs useful in the treatment of diseases.
2:00Introduction.
2:05
Towards an Atomic-Level Understanding of Psychoactive
Drug Actions. Bryan Roth. Univ. of North Carolina at
Chapel Hill.
SUNDAYPHARMACOLOGY
176. ASPET PRESIDENTIAL SYMPOSIUM: PRECISION
MEDICINE IN ANTI-CANCER PHARMACOLOGY
Symposium
Symposium
(Cosponsored by: The Divisions for Cancer
Pharmacology, Cardiovascular Pharmacology, and
Translational and Clinical Pharmacology)
Cochaired: K.E. Thummel and S.P. Cole
Cancer Biology
3:00
3:10
3:45
4:20
4:55
Overview of Precision Medicine. K. Thummel. Univ.
of Washington.
Pharmacogenomics: A Foundation of Precision Medicine
for Leukemia. W.E. Evans. St Jude Children’s
Res. Hosp.
Genome-Wide Studies of Chemotherapeutic-Associated
Toxicities. M.E. Dolan. Univ. of Chicago.
Use of Tumor Genomics to Customize Drug Treatment
in Women with Triple Negative Breast Cancer.
C.A. Blau. Univ. of Washington.
Breast Cancer Pharmacogenomics: Application of PDX
Model. L. Wang. Mayo Clin.
177. CANNABINOID SIGNALING IN PAIN AND
ADDICTION: TRANSLATING PRECLINICAL
BASIC RESEARCH TO THE CLINIC
Symposium
(Sponsored by: The Division for Neuropharmacology)
(Cosponsored by: The Divisions for Behavioral
Pharmacology, Molecular Pharmacology, Drug
Discovery and Development, and Translational and
Cochaired: D. Morgan and J. Guindon
Neuropharmacology
Neurobiology
3:00
3:30
4:00
4:30
5:00
178. DOSE SELECTION USING PHYSIOLOGICALLY
BASED MODELING
Allosteric Modulators of Cannabinoid Receptor Function.
K. Mackie. Indiana Univ.
Cannabidiol as an Anti-inflammatory/Analgesic and
Potential Anti-addictive Treatment. E. Russo. Phytecs.
Endocannabinoids in Circulation and Pain. C. Hillard.
Med. Col. of Wisconsin.
Insights into the Mechanisms of Tolerance for
Cannabinoid Drugs. J. Guindon. Texas Tech Univ.
Hlth. Sci. Ctr.
Role of the Endocannabinoid System in Addiction.
R. Maldonado. Univ. Pompeu Fabra, Barcelona.
(Cosponsored by: The Division for
Pharmacology Education)
Chaired: J. Wahlstrom
Drug Metabolism
3:00Introduction.
3:05
Translation of Preclinical Information to Clinical Dose
Selection Using PBPK Approaches. H. Jones. Pfizer
Worldwide R&D.
3:35 Mechanistic Insights to the Prediction of Nonlinear
Pharmacokinetics. J. Wahlstrom. Amgen, Inc.
4:05 Modeling and Simulation to Support Pediatric Drug
Development. A. Edginton. Univ. of Waterloo.
4:35 Predicting the Effects of Cytokine Modulation on
Pharmacokinetics Using PBPK. Y. Xu. Amgen, Inc.
5:05 Simulating Biodistribution and Pharmacokinetics for
Protein Therapeutics Using PBPK. P. Glassman.
Univ. at Buffalo.
179. SEX DIFFERENCES IN CARDIOVASCULAR AND
RENAL PHARMACOLOGY
Symposium
(Sponsored by: The Division for
Cardiovascular Pharmacology)
Cochaired: S.H. Lindsey and E.Y. Gohar
Cardiovascular Pharmacology
3:00Introduction.
3:05
Sex-Specific Immune Mechanisms in Vascular Disease.
K. Sandberg. Georgetown Univ. Med. Ctr.
3:30
Double-Edged Sword: Sex Hormones in Renal Health.
M. Zimmerman. Tulane Univ.
3:55 Sexual Dimorphism in Nicotine Interaction with
Baroreflex Control of Heart Rate. M. El-Mas.
Alexandria Univ., Egypt.
4:20 Sex Hormones and Vascular Protection: Clinical
Implications. F. Hage. Univ. of Alabama at Birmingham.
4:45
Sex Specific Differences in Key Signaling Pathways
Involved in Sympathetic Nervous System Control
within the Dorsal Medulla of Adult Sheep with Fetal
Betamethasone Exposure. A.S. Hendricks, D.I. Diz,
H.A. Shaltout, M.C. Chappell. Wake Forest Sch. of
Med. (716.5)
5:00
Sex-Based Differences in the Aortic Function of UCDT2DM Rats: A Novel Rat Model of Type 2 Diabetes
Mellitus. F. Akther, S. Shaligram, M.D. Karimi, J.L.
Graham, K.L. Stanhope, P.J. Havel, R. Rahimian.
Sch. of Pharm., Univ. of Pacific and Univ. of California,
Davis. (716.1)
59
S
U
N
PHARMACOLOGYSUNDAY
5:15
The Effects of Sex and Genotype on the Population
Pharmacokinetics and Pharmacodynamics Modeling
and Simulation of Low Dose Epinephrine and Cardiac
Output. A.R. Eugene, M. Joyner. Mayo Clin. (716.4)
Division Symposium
Pharmacology Education)
Hotel, San Diego Ballroom B
180. FROM LIGANDS TO SIGNALING: RECENT
ADVANCES IN ADHESION GPCR
PHARMACOLOGY AND BIOLOGY
Cochaired: M.A. Simmons and R. Theobald, Jr.
Symposium
(Sponsored by: The Division for Molecular Pharmacology)
Education
(Cosponsored by: The Divisions for Drug Discovery
and Development, Neuropharmacology, Cancer
Pharmacology, and Cardiovascular Pharmacology )
Participants are encouraged to bring their laptops to this
workshop. Attendees will work through exercises in small groups
with the authors of the revised POPs (patient-oriented problemsolving system) serving as facilitators.
3:00
Cochaired: X. Piao and R.A. Hall
Molecular Pharmacology
Cancer Biology
Neurobiology
3:00
3:25
3:50
4:15
4:40
5:05
Signaling and Regulation of the BAI Subfamily of
Adhesion GPCRs. R. Hall. Emory Univ. Sch. of Med.
Structural Organization of the Extracellular Domains of
Adhesion GPCRs. D. Arac-Ozkan. Univ. of Chicago.
Adhesion GPCRs are Turned on by Tethered Ligands.
T. Schöneberg. Univ. Leipzig.
Adhesion GPCR Activation by Tethered Agonist
Decryption and Small Molecule Antagonism. G. Tall.
Univ. of Rochester Med. Ctr.
In Vivo Small Molecule Screens Define Modulators of
Adhesion GPCR Signaling. S. Petersen. Washington
Univ. - St. Louis.
GPR56 and its Ligand in Oligodendrocyte Development
and Myelination. X. Piao. Boston Children’s Hospital.
181. DIVISION FOR PHARMACOLOGY EDUCATION
SYMPOSIUM: MEET THE NEW POPS – THEY’LL
FLIP YOUR TEACHING
3:15
5:15
A Brief History of the POPS and Presentation of Their
Current Structure. M. Simmons. Univ. of Maryland
Eastern Shore.
Facilitated Exercises:
Treatment of Essential Hypertension. M. Simmons.
Univ. of Maryland Eastern Shore.
Treatment of Cardiac Arrhythmias. J. Yun. Northeast
Ohio Med. Univ.
Drug Treatment of Heart Failure. R. Rockhold. Univ. of
Mississippi Med. Ctr.
Therapy of Diabetes Mellitus. J. Reuben. Univ. of South
Carolina Sch. of Med. Greenville.
Treatment of Psychosis. G. Athauda. Florida Intl. Univ.
Drug Overdose Toxicity. R. Theobald, Jr. A.T. Still Univ.
- Kirksville Col. of Osteo. Med.
Summary and Discussion. R. Theobald, Jr. A.T. Still
Univ. - Kirksville Col. of Osteo. Med.
182. STUDENT/POSTDOC POSTER COMPETITION
Poster Award Competition
Ballroom 20BC
ASPET Divisions award prizes to undergraduates, graduate
students, and postdocs making the best poster presentations at
this event. Join us to view the top student/posdoc posters.
60
SUNDAYPHYSIOLOGY
Physiology
183. APS PRESIDENT’S SYMPOSIUM SERIES
PHYSIOLOGICAL MECHANISMS
RESPONSIVE TO BEHAVIORAL AND
ENVIRONMENTAL CHALLENGES
PHYSIOLOGICAL PROCESSES UNDERLYING
ORGAN INJURY IN ALCOHOL ABUSE
9:30
9:45
Symposium
Ballroom 20A
Chaired: G. Murray and F.M. Souza
Regulation of Protein Synthesis in Cardiac and Skeletal
Muscle. C. Lang. Penn State Col. Med.
11:00 Adipose Tissue as a Target for Excess Alcohol
Consumption. L. Nagy. Cleveland Clin. Fndn.
11:30 Liver Mitochondrial Stress and Energy Metabolism.
S. Bailey. Univ. of Alabama at Birmingham.
12:00 Role of the Endocannabinoid System in Mediating the
Neural Adaptations to Alcohol. L. Parsons. Scripps
Res. Inst.
185. MICROBIOME IN CARDIOPULMONARY
DISEASES: FROM ASSOCIATION
TO CAUSATION
Symposium
10:30
184. ADVANCES IN RENAL PHYSIOLOGY I
Featured Topic
(Sponsored by: APS Cardiovascular Section)
Chaired: V. Shenoy and J. Pluznick
Microbiome
8:00
8:30
9:00
(Sponsored by: APS Renal Section)
Essential Involvement of Purinergic Signaling in
Calcium Handling in the Podocytes of Type 2 Diabetic
Rats. D. Ilatovskaya, O. Palygin, A. Lowing, V.
Levchenko, J. Lazar, A. Staruschenko. Med. Col. of
Wisconsin. (740.4)
Protective Role of AMPK in Sepsis Associated AKI. Y. Li,
N. Nourbakhsh, E. Hall, M. Hepokoski, H. Pham,
J. Thomas, P. Singh. UCSD and VA San Diego
Healthcare Syst. (1217.18)
9:30
Non-Lethal inhibition of a Gut Microbial Pathway for
the Treatment of Cardiovascular Disease. S. Hazen.
Cleveland Clinic.
Impact of Microbial Alterations on Salt Sensitive
Hypertension. B. Joe. Univ. of Toledo.
Gut Microbiota-Derived Signals and Blood Pressure
Regulation. N. Natarajan. Johns Hopkins Univ.
Gut Microbial Dysbiosis in Pulmonary Hypertension:
Impact and Opportunities. V. Shenoy. Univ. of Florida.
Chaired: P.R. Grimm and P.S. Caceres
Ion Transport
8:00
8:15
8:30
8:45
9:00
9:15
Targeted Knockin of Constitutively Active SPAK in
the Early Distal Convoluted Tubule (DCT1) Causes
Hyperkalemic Hypertension. P.R. Grimm, R.
Coleman, E. Delpire, P.A. Welling. Univ. of Maryland
Sch. of Med. and Vanderbilt Univ. Med. Sch. (967.10)
Role of the Novel Kinase TNIK on NKCC2 Surface
Expression, Phosphorylation and Na Reabsorption in
the Thick Ascending Limb. P.S. Caceres, P.A. Ortiz.
Henry Ford Hosp. and Wayne State Univ. (967.12)
Knockout of Na-Glucose Transporter SGLT1 Lowers
GFR and Kidney Weight in Non-diabetic and Akita
Diabetic Mice. P. Song, Y. Fu, A. Onishi, H. Qiu,
H. Koepsell, V. Vallon. UCSD and VA San Diego
Healthcare Syst., Central South Univ., China and Inst.
of Anat. and Cell Biol., Würzburg, Germany. (740.21)
T Cell Infiltration in Kidney Induces Salt-Retention via
NCC Up-Regulation. S. Mu, Y. Liu. Univ. of Arkansas
for Med. Sci. (966.4)
The cGMP/PKG Signaling Pathway Underlies the
Inhibitory Effect of Sildenafil Citrate on NHE3 Activity
in Rat Renal Proximal Tubules. P.M.C. dos Santos,
T.D. Pessoa, G. Malnic. Univ. of São Paulo. (967.14)
Internalization of Angiotensinogen in Renal Proximal
Tubules: Evidence for Mitochondrial Trafficking.
B. Wilson, N. Cruz-Diaz, Y. Su, J.C. Rose, M.C.
Chappell. Wake Forest Sch. of Med. (967.5)
186. MUSCLE DYSFUNCTION IN DIABETES:
CAUSE(S) OR EFFECT(S)?
Featured Topic
(Sponsored by: APS Muscle Biology Group)
Chaired: J. Brozinick
8:00
8:15
Alterations in Muscle Metabolism from Exercise Trained
Diabetic Humans. J. Zierath. Karolinska Univ.
8:30 Improved Insulin-Mediated Glucose Oxidation in
Cultured Human Myotubes following Roux-en-Y
Gastric Bypass Surgery. K. Zou, J.M. Hinkley, S.
Park, D. Zheng, G.L. Dohm, J.A. Houmard. East
Carolina Univ. (770.4)
8:45
Higher Cell Growth/Viability Accompanied by Reduced
Myosin Heavy Chain Expression in Skeletal Muscle
Cells Derived from Severely Obese Type 2 Diabetic
Humans. K.D. Turner, K. Zou, M. Hinkley, S. Park, D.
Zheng, J. Houmard. East Carolina Univ. (770.5)
9:00
The Role of Ankrd2 in Obesity-Induced Inflammation
and Insulin Resistance. A.M. Hernandez-Carretero,
N. Weber, N.Y.T. Doan, O. Osborn. UCSD and
Pomona Col., CA. (770.3)
61
S
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PHYSIOLOGYSUNDAY
9:15
9:30
Obesity Distinctly Influences Cardiac Function and
Molecular Responses to Ischemia-Reperfusion
and GLP-1 Receptor Agonism. D.J. Sassoon, A.G.
Goodwill, J.N. Noblet, A.M. Conteh, B.P. Herring,
J. McClintick, J.D. Tune, K.J. Mather. Indiana Univ.
Sch. of Med. (770.1)
Myostatin Inhibition as an Adjuvant Therapy in Type
1 Diabetes Mellitus. T.J. Hawke, S. Coleman,
I. Rebalka, D. D’Souza, N. Deodhare. McMaster
187. NCAR YOUNG INVESTIGATOR AWARDS
Featured Topic
Regulation Section)
Chaired: R. Ramchandra and R. Sabharwal
Neurobiology
Neurophysiology
8:00
Sympathetic Overactivity: The Missing Link in Nonalcoholic Fatty Liver Disease? C. Young. George
Washington Univ.
8:30
Norepinephrine-Mediated Suppression of T-Lymphocyte
Activation Is Regulated by Mitochondrial Redox
Mechanisms. A.J. Case, M.C. Zimmerman. Univ. of
Nebraska Med. Ctr. (757.1)
8:45 Central Anti-inflammatory and Neuronal Effects
of Butyrate in Wistar Kyoto and Spontaneously
Hypertensive Rats. T. Yang, V. Rodriguez, L. ColonPerez, T. Redler, M. Febo, C. Sumners, J. Zubcevic.
Univ. of Florida. (757.2)
9:00
Renal Nerves, Renal Inflammation and Hypertension in
Deoxycorticosterone Acetate-Salt Hypertension: Who
Is in the Driver’s Seat? C.T. Banek, J.D. Foss, D.A.
Van Helden, N. Asirvatham-Jeyaraj, J.W. Osborn.
Univ. of Minnesota, Minneapolis and Vanderbilt Univ.
(757.3)
9:15 Renal Function in Normotensive Sheep in the First
Fourteen Weeks after Catheter-Based Renal
Denervation. L.C. Booth, Z. McArdle, S.T. Yao,
S. Malone, Y. Lankadeva, J. Kosaka, M. Schlaich,
C.N. May. Florey Inst. of Neurosci. and Ment. Hlth.
and IDI Heart & Diabetes Inst., Melbourne. (757.4)
9:30
Neuronal Activation of ADAM17 by AT1A Receptors
Contributes to Neurogenic Hypertension. J. Xu,
S. Sriramula, E. Lazartigues. LSU Hlth. Sci. Ctr.,
New Orleans. (757.5)
9:45 Prostaglandin E2 and Its EP3 Receptors Contribute
to Dendritic Cell and Memory T Cell Activation in
Mice with L-NAME/High Salt-Induced Hypertension.
L. Xiao, H.A. Itani, M.P. Kraemer, R.M. Breyer, D.G.
Harrison. Vanderbilt Univ. (757.6)
188. NEURAL AND HORMONAL MODULATION OF
FLUID BALANCE AND ION HOMEOSTASIS IN
HEALTH AND DISEASE
Featured Topic
Chaired: C. Banek and H. Lob
8:00 Vasopressin Receptor Regulation in Maintaining
Potassium Homeostasis in a Sus scrofa Model of
Hemorrhagic Shock. C.F.T. Uyehara, L.N. Kajiura,
L-A.M. Murata, S.A. Wong, W.M. Ichimura, C.A.
Hernandez, J. Sarkar, M.R. Rowland. Tripler Army
Med. Ctr., HI. (962.1)
8:15
High Salt Activation of Collecting Duct-Derived Nitric
Oxide Synthase Suppresses the Renin-AngiotensinAldosterone System. J.S. Pollock, D.M. Pollock,
C. Dugas, K.A. Hyndman. Univ. of Alabama at
Birmingham. (962.5)
8:30 Salt and Angiotensin II Treatment Induces Fluid
Congestion and Heart Failure with Increased Mortality
in Balb/C Mice but Not in C57BL/6J. S.T. Joensson, M.
Becriovic-Agic, M. Hulström. Uppsala Univ. (962.6)
8:45 Chronic Vagus Nerve Stimulation Attenuates Renal
Inflammation in Autoimmune-Induced Hypertension.
G.S. Pham, A.S. Fairley, C.I. Maloy, K.W. Mathis.
Univ. of North Texas Hlth. Sci. Ctr. (962.7)
9:00
The Neuroimmune Axis in Hypertension. D. Harrison.
Vanderbilt Univ.
9:30 Renal Denervation Normalizes Blood Pressure and
Improves Glucose Metabolism in Obese Genetically
Hypertensive Schlager Mice. N. Asirvatham-Jeyaraj,
C.T. Banek, R. Han, M. Razzoli, B.J. Burbach, A.
Bartolomucci, Y. Shimizu, J.W. Osborn. Univ. of
Minnesota, Minneapolis. (962.9)
9:45
Renal Afferent Nerve Modulation of Sodium Homeostasis
and Blood Pressure: A Sodium Sensitive Mechanism
Countering the Development of Salt-Sensitive
Hypertension? R.D. Wainford, K.R. Walsh, C.Y.
Carmichael. Boston Univ. (962.3)
189. NEW INSIGHTS INTO EXERCISE AND
INSULIN SENSITIVITY
Symposium
(Sponsored by: APS Endocrinology and
Metabolism Section)
Chaired: E. Richter and G. McConell
Skeletal Muscle Physiology
8:00
8:30
62
Introduction and Role of Rac1 in insulin Sensitivity After
Exercise. E. Richter. Univ. of Copenhagen.
The Role of AMPK in Insulin Sensitivity after Exercise.
J. Wojtaszewski. Univ. of Copenhagen.
SUNDAYPHYSIOLOGY
9:00
9:30
The Role of Skeletal Muscle Microvascular Flow in
Contraction and Insulin-Stimulated Glucose Uptake.
M. Keske. Menzies Inst. for Med. Res., Univ.
of Tasmania.
The Role of Nitric Oxide in the Insulin Sensitizing Effects
of Exercise. G. McConell. Victoria Univ.
190. PHYSIOLOGICAL AND
PATHOLOGICAL ASPECTS OF
HYPERTROPHIC CARDIOMYOPATHY
Symposium
Chaired: S. Steinberg and S. Sadayappan
Myocardial Infarction/Heart Failure
8:00
Cardiac Remodeling by Redox-Activated Protein Kinase
C-delta. S. Steinberg. Columbia Univ.
8:30
The Importance of the Ubiquitin Proteasome System
in
Hypertrophic
Cardiomyopathy
Associated
with Troponin Mutations. A. Gomes. Univ. of
California, Davis.
9:00Ca2+ Sensitizing TroponinT Mutations Alter Coronary
Perfusion and Cardiac Energetics. S. Huke.
Vanderbilt Univ.
9:30
Molecular Mechanism of Hypertrophic Cardiomyopathy
in Populations of South Asian Descendants.
S. Sadayappan. Loyola Univ. Chicago.
191. STANDING ON THE EDGE:
TRANSFORMATIONAL TEACHING AND
LEARNING BEYOND THE CLASSROOM WALLS
Symposium
(Sponsored by: APS Teaching of Physiology Section)
Chaired: A.R. Crecelius and J.C. Taylor
Education
8:00
8:30
8:50
9:10
9:30
Always a Teacher, Always a Student. M. Joyner.
Mayo Clin.
Speaking English, Speaking Science: Undergraduates
Show Language Learners the PhUn of Physiology.
P. Halpin. Univ. of New Hampshire Manchester.
Experiential Learning in Exotic Locations A. Bunker.
Morningside Col., IA.
Citizen Science: Public Participation in the Research
Process. N. Garneau. Denver Museum of Nature
and Sci.
Panel Discussion.
192. TRAINEE HIGHLIGHTS IN
PHYSIOLOGICAL GENOMICS
Featured Topic
Chaired: A. Kriegel and H. Cai
8:00
Deficiency in the Anti-aging Gene Klotho Promotes
Aortic Valve Fibrosis through AMPKα-Mediated
Activation of RUNX2. J. Chen, Y. Lin, Z. Sun. Univ. of
Oklahoma Hlth. Sci. Ctr. (1260.7)
8:15 Exercise Training in the Metabolic Syndrome
Improves Perivascular Adipose Gene Expression.
E. DeVallance, K. Branyan, K. Lemaster, R. Skinner,
S. Brooks, W. Sheets, R. Bryner, J. Frisbee,
P. Chantler. West Virginia Univ. (771.9)
8:30
Phosphorylation of α-Actinin-4 at Serine 159 Mimics the
Biochemical and Cellular Effects of Human Kidney
Disease Mutations. D. Feng, R. Krishnan, L. Stella,
M. Schenone, C.R. Hartigan, M.R. Pollak. Beth
Israel Deaconess Med. Ctr. and Havard Med. Sch.,
Univ. of Rome Tor Vergata and Broad Inst. of Harvard
and MIT. (771.1)
8:45
MiR9 Is Increased in Rheumatoid Arthritis Monocytes
and Regulates Monocyte Migration. J. Gaudette,
W.A. Stinson, D.A. Fox, M.A. Amin, B.J. Rabquer.
Albion Col. and Univ. of Michigan. (1028.11)
9:00 Fruit and Vegetable Intervention Lowers Circulating
Ceramide Levels and Improves Estimated Insulin
Sensitivity in Young Adults at Risk of Developing
Metabolic Syndrome: A FRUVEDomic Pilot Study.
A.T. Mathews, O.A. Famodu, M.D. Olfert, P.J.
Murray, C.F. Cuff, M.T. Downes, N.J. Haughey, S.E.
Colby, I.M. Olfert, J.W. McFadden. West Virginia
Univ., John Hopkins Univ. and Univ. of Tennessee,
Knoxville. (1260.3)
9:15 The MicroRNA let-7f Regulates Expression of the
Voltage-Gated Mechanosensitive Ion Channel
NaV1.5 in Human Gastrointestinal Smooth Muscle.
A. Mazzone, P.R. Strege, C.E. Bernard, R.R. Cima,
D.W. Larson, E.J. Dozois, Y. Hayashi, T. Ordog,
S.J. Gibbons, A. Beyder, G. Farrugia. Mayo Clin.
(1028.10)
9:30
Altered DNA-Damage/BRD4 Signaling Pathways in the
Lungs of Patients with Pulmonary Hypertension Can
Propagate to the Coronary Vasculature and Induce
Coronary Artery Disease. J. Meloche, V. Nadeau, E.
Tremblay, F. Potus, S. Chabot, E. Charbonneau,
S. Provencher, S. Bonnet. Laval Univ., Canada.
(1260.9)
9:45 Deletion of the Prorenin Receptor in the Collecting
Duct Impairs Renal Function and Attenuates Blood
Pressure in Chronic Angiotensin II-Infused Mice.
V. Reverte Ribo, V.R. Gogulamudi, A.A. Gonzalez,
C.B. Rosales, M.R. Gallaty, A. Castillo, A. Ichiara,
L.G. Navar, M.C. Prieto. Tulane Univ., Pontifical
Catholic Univ.of Valparaíso, Chile and Kumamoto
Univ., Japan. (1260.1)
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193. TRANSLATIONAL PHYSIOLOGY SHOWCASE:
FOCUS ON THE EFFECTS OF ALCOHOL
ABUSE, BEHAVIOR, DIET, NUTRITION, AND
EXTREME ENVIRONMENTAL CONDITIONS
ON PHYSIOLOGY
Featured Topic
(Sponsored by: APS Translational Physiology
Interest Group)
Chaired: C.N. Young and B.T. Bikman
8:00
Introduction to talks and format.
9:06
9:13
9:19
Topics in Extreme Environmental Conditions
9:27
Topics in Alcohol Abuse
8:03 Downregulation of Hepatic ecto-5′-Nucleotidase
(CD73) in a Mouse Model of Alcoholic Liver Injury
and in Patients with Alcoholic Steatohepatitis.
M.L. Richardson, H.H. Willcockson, G. Odena,
R. Bataller, N. Snider. Univ. of North Carolina at
Chapel Hill. (1249.7)
8:10 In Utero Exposure to Alcohol Alters Reactivity of
Cerebral Arterioles. S.G. Cananzi, W.G. Mayhan.
LSU Hlth. Sci. Ctr., Shreveport. (953.14)
8:17 Claudin-5 Decreases Alveolar Barrier Function in
Alcoholic Lung Syndrome by Displacing Claudin-18
from Tight Junctions. B.L. Schlingmann, S. Dorsainvil
White, S. Molina, K.S. Lynn, C.T. Capaldo, M. Koval.
Emory Univ., Sch. of Med. Emory Univ. (1264.6)
8:24 Tolerance to Alcohol-Stimulated Glutamate Receptor
Phosphorylation in the Central Amygdala and
Prefrontal Cortex after Chronic Nicotine Exposure.
M.A. McGinn, C.A. Itoga, R.I. Paulsen, J.E. Reppel,
M.A. Farooq, N.W. Gilpin, S. Edwards. LSU Hlth.
Sci. Ctr., New Orleans. (992.5)
8:30
Topics in Behavior, Diet and Nutrition
8:38
8:45
8:52
8:59
64
Distribution Pattern of Dietary Protein Intake Does
Not Affect Anabolic Response, Lean Body Mass,
Muscle Strength or Function Over 8 Weeks in Older
AdultsI-Y. Kim, S. Schutzler, G. Azhar, R. Wolfe,
A. Ferrando. Univ. of Arkansas for Med. Sci. (1016.2)
Dietary Nitrate (NO3-)-Induced Increases in Skeletal
Muscle Contractile Function: High versus Low
Responders. A.R. Coggan, D. Mikhalvkova, K.
Mahmood, I. Bole, J. Leibowitz, A. Kadkhodayan,
S. Park, D. Thomas, D. Thies, L.R. Peterson.
Washington Univ. Sch. of Med. (1245.28)
Maternal Protein Intake as a Determinant of the Total
Number of Motor Units and Muscle Fibres in Mice.
A. Vasilaki, I. Giakoumaki, N. Pollock, K. GoljanekWhysall, A. McArdle, A.A. Sayer. Univ. of Liverpool
and Newcastle Univ. (1009.10)
Metabolic Dysfunction Induced by Prenatal Exposure
to Bisphenol-A and Diethyl Hexyl Phthalate:
Exacerbation by High Fat Diet. C.K. Hahn-Townsend,
P.A. Varde, P.S. MohanKumar, S.M. MohanKumar.
Univ. of Georgia and Michigan State Univ. (1293.6)
Exposure to a Diet High in Saturated-Fat during Prenatal and Post-weaning Brain Development Alters
Hippocampal Gene Expression and Behavioral
Indices for Anxiety and Depression. K.C. Page, M.E.
Winkelmann, E.K. Anday. Bucknell Univ. and Drexel
Univ. Col. of Med. (749.7)
Enhanced Dietary Fructose Rapidly Induces SaltSensitive Hypertension in Rats. K.L. Gordish, P.A.
Ortiz, J.L. Garvin, W.H. Beierwaltes. Henry Ford
Hosp. and Case Western Reserve Univ. (1216.1)
9:34
9:41
9:48
9:54
Maternal Chronic Intermittent Hypoxia during Gestation
Programs Hypercholesterolemia in the Offspring.
J. Ciriello, W. Iqbal, D. Hardy. Univ. of Western
Ontario. (1247.14)
Chronic Heat Preconditioning Enhances Skeletal
Muscle Function during Hypoxia and Reoxygenation.
L. Zuo, W.J. Roberts, B.K. Pannell. The Ohio State
Univ. and Oakland Univ., MI. (1245.17)
Kidney Injury Marker-1: A Potential Point-of-Care
Biomarker of Heat Stress. G.N. Audet, J.A. Ward,
S.M. Dineen, S.N. Cheuvront, L.R. Leon. U.S. Army
Res. Inst. of Envrn. Med., Natick, MA. (1243.3)
Control of Lung Ventilation after Extended Disuse
Caused by Overwintering Submergence in the Bullfrog.
J. Santin, L. Hartzler. Wright State Univ. (760.24)
194. BRIDGING THE GAP BETWEEN PRE-CLINICAL
AND CLINICAL EVIDENCE: TREATING
CARDIOVASCULAR DISEASES WITH
AUTONOMIC MODULATION THERAPIES
Symposium
Regulation Section)
Chaired: S. Ruble and K. Sunagawa
Neurobiology
Hypertension
10:30 Deep Brain Stimulation for Hypertension. A. Green.
Oxford Univ.
11:00 Carotid Sinus Stimulation for Hypertension. J. Tank.
Hannover Med. Sch., Germany.
11:30 Vagal Nerve Stimulation for the Treatment and
Prevention of Heart Failure. K. Saku. Kyushu
Univ., Japan.
12:00 Vagal Nerve Stimulation for Arrhythmias. A. Talkachova.
Univ. of Minnesota.
SUNDAYPHYSIOLOGY
195. CLAUDE BERNARD DISTINGUISHED
LECTURESHIP OF THE APS TEACHING OF
PHYSIOLOGY SECTION
197. MACROPHAGES: A DOUBLE-EDGED SWORD IN
INFLAMMATORY TISSUE INJURY
Symposium
Lecture
(Sponsored by: APS Respiration Section)
Chaired: D. Mehta and F.R. D’Alessio
Education
An
Evolution
in
Student-Centered
Teaching.
B. Goodman. Univ. of South Dakota Sanford Sch.
of Med.
196. EPITHELIAL PHYSIOLOGY AND TRANSPORT I
Featured Topic
Chaired: J. Bomberger and N. Bradbury
Microbiome
Ion Transport
Barriers: Endothelium and Epithelium
Hans Ussing Lecture. CFTR Cl Channels and Cystic
Fibrosis. B. Stanton. Dartmouth Univ.
11:15 Inducible Renal Tubule-Specific Insulin Receptor
Knockout Mice Have Decreased NCC-Mediated
Sodium Reabsorption and Reduced Sensitivity to
Mineralocorticoid-Induced Hypertension in Obesity
and Insulin Resistance. J.M. Nizar, E.M. Walczak,
W. Dong, L. Bankir, V. Bhalla. Stanford Univ. and
Cordeliers Res. Ctr., INSERM, Paris. (968.1)
11:30 Salt-Losing Nephropathy in Mice with a Null Mutation of
Clcnkb. A. Grill, I.M. Schiessl, A. Hammer, H. Castrop.
Inst. of Physiol, Regensburg, Germany. (968.2)
11:45 Down-Regulation of Kir4.1 Eliminates the Basolateral
K Conductance in the Distal Convoluted Tubule and
Inhibits NCC Activity. X-T. Su, M-X. Wang, P. Wu, J.A.
McCormick, D.E. Ellison, W-H. Wang. New York
Med. Col. and Oregon Hlth. & Sci. Univ. (968.3)
12:00 Tight Junction Protein Abundance Is Altered in
Metformin-Treated Airway Epithelial Cells. K.K. Kalsi,
J.P. Garnett, E.H. Baker, D.L. Baines. St. George’s
Univ. of London and Newcastle Univ., U.K. (968.4)
12:15 Hydrocortisone Affects the Transport Phenotype of
Differentiated Normal Human Bronchial Epithelial Cells.
N. Zaidman, A. Panoskaltsis-Mortari, S.M. O’Grady.
Univ. of Minnesota, Minneapolis and St. Paul. (968.5)
10:30 Macrophage Plasticity and Lung inflammation.
B. Moore. Univ. of Michigan Med. Sch.
10:55 Engulfment of Pathogens and Their Ligands by
Phagocytosis and Macropinocytosis. S. Grinstein.
Univ. of Toronto.
11:20Communication
between
Macrophages
and
Alveolar Barrier Regulates Lung inflammation.
J. Bhattacharya. Columbia Univ. Col. of P&S.
11:45 Macrophage Reprogramming Accelerates Ali Resolution
and Lung Repair. N. Aggarwal. Johns Hopkins Univ.
12:10 S1P-Generating Macrophages and Lung Vascular Barrier
Regulation. D. Mehta. Univ. of Illinois Sch. of Med.
198. METABOLIC SYNDROME AND THE PATHWAY
OF DRUG DEVELOPMENT: FROM BENCH
TO BEDSIDE
10:30
Symposium
(Sponsored by: APS Physiologists in Industry Committee)
Chaired: M.R. Zahner and D.C. Cornelius
10:30
11:00
11:30
12:00
The Potent Effects of Bariatric Surgery as a Platform for
Developing New Therapies for Obesity and Diabetes.
R. Seeley. Univ. of Michigan.
Signaling without Barriers: Integrated Roles for individual
Peptide Neurotransmitters in the Regulation of
Cardiovascular, Metabolic and Neuroendocrine
Systems. A. Furguson. Queens Univ. Sch. of Med.
Bridging Cardiovascular Safety Pharmacology into the
Clinical Realm. H. Vargas. Amgen.
Clinical Trials: Navigating the Clinical Phases from FIH
to Post-marketing and the Regulatory Processes to
Market a Product. C. Mesner. Pfizer, Inc.
199. MICROBIOTA OR NUTRITION AND HOST
CELL SIGNALING
Featured Topic
(Sponsored by: APS Cell and Molecular
Physiology Section)
Chaired: R. Worrell and M. Butterworth
Microbiome
10:30
Coxiella burnetii Infection of Host Cells Involves PKC
Substrate MARCKS. S. Whitlock, C.J. Funk. John
Brown Univ. (744.3)
65
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10:45
Mechanism of Action of Lactobacillus reuteri ATCC PTA
6475 in Colon Epithelial Cells. N.D. Rios-Arce, R.A.
Britton, L. McCabe, N. Parameswaran. Michigan
State Univ. and Baylor Col. of Med. (744.5)
11:00 Comparative Analysis of Biotransformation of transResveratrol in Worms, Flies, Mice and Humans.
S.E. Kulling, S.T. Soukup, F. Rieck, B. Spanier,
C. Schulze, S. Piegholdt, G. Rechkemmer, A.E.
Wagner, A. Bub, G. Rimbach, H. Daniel. Max
Rubner Inst., Karlsruhe, TU München and Univ. of
Kiel, Germany. (744.2)
11:15 Indigenous Bacteria from the Gut Microbiota Regulate
Host Serorotonin Biosynthesis. E. Hsiao. California
Inst. of Technology.
11:45 Interplay between Nutrition and Environment in Altering
the Gut Microbiome and Susceptibility to Type 2
Diabetes. M. Schaid, J. Neuman, J. Wisinski, A.
Reuter, E. Laundre, R. Fenske, M. Kimple. Univ. of
12:00 EriC2 Regulates Histamine Production Machinery via an
Ion Transport-Dependent Mechanism in Lactobacillus
reuteri. A. Hall, M. Engevik, J. Versalovic. Baylor
Col. of Med. and Texas Children’s Hosp. (744.6)
12:15 Renal Olfactory Receptor 90 Responds to Fungal
Metabolites. V.L. Halperin Kuhns, J.L. Pluznick.
Johns Hopkins Univ. (744.4)
200. OMICS APPLICATIONS IN
METABOLIC PHYSIOLOGY
Symposium
(Sponsored by: APS Physiological Genomics Group and
The American Society for Nutrition)
Chaired: M. Olfert and S. Adams
10:30 Metabolomics and the Physiology of Exercise and
Insulin Resistance. S. Adams. Univ. of Arkansas for
Med. Sci.
11:00 The Sphingolipidome and Insulin Resistance:
Perspectives Gained from Studying the Overweight
Dairy Cow Transitioning From Gestation to Lactation.
J. McFadden. West Virginia Univ.
11:30 Genes, Exercise and Angiogenesis: Implications for the
Metabolome. M. Olfert. West Virginia Sch. of Med.
12:00 Metabolic Processes and Physiological Parameters
Involved with the Ischemia/Reperfusion Protective
Phenotype
in
Hibernators.
L.K.
Bogren,
A. D’alessandro, T.G. Nemkov, K.C. Hansen, S.L.
Martin. Univ. of Colorado Anschutz Med. Campus,
Aurora. (1260.2)
12:15 Depletion of Dietary microRNAs from Cow’s Milk
Causes an Increase of Purine Metabolites in Human
Body Fluids and Mouse Livers. A. Aguilar Lozano.
Univ. of Nebraska, Lincoln.
201. RENAL SECTION YOUNG INVESTIGATOR
SYMPOSIUM: NOVEL SIGNALING AND
TRANSPORT MECHANISMS IN THE
COLLECTING DUCT
Featured Topic
Chaired: M.C. Prieto-Carrasquero and J. Peti-Peterdi
10:30 Renal Section Young Investigator Award Lecture.
M. Prieto. Tulane Univ. Sch. of Med.
11:00 Lack of the Prorenin Receptor in the Collecting Duct
Blunts the ENaC Responses to Chronic Angiotensin II.
A.A. Gonzalez, V. Reverte-Ribo, A. Katsurada, C.B.
Rosales, M. Galatty, M. McLellan, O. Gentile, L.C.
Veiras, D.M. Seth, A. Ichihara, A.A. Mc Donough,
M. Mamenko, O.M. Pochynyuk, L.G. Navar, M.C.
Prieto. Pontifical Catholic Univ. of Valparaíso, Chile,
Tulane Univ., Tokyo Women’s Med. Univ., Keck Sch.
of Med. of USC and Univ. of Texas Hlth. Sci. Ctr. at
Houston. (741.1)
11:15 High K+ Intake Attenuates ARPKD Progression by
Activation of TRPV4-Mediated Ca2+ Signaling in
Cyst Cells. M. Mamenko, V. Tomilin, O. Zaika, O.
Pochynyuk. Univ. of Texas Hlth. Sci. Ctr. at Houston.
(741.10)
11:30 EHD4 Deletion Results in a Urine Concentrating Defect
in Mice. S.S. Rahman, A.E.J. Moffitt, M. Storck,
H. Band, E.I. Boesen. Univ. of Nebraska Med. Ctr.
(741.7)
11:45 ENaC in Renal Cortical Collecting Duct Principal Cells
Is Stimulated by Increasing Intracellular Ca2+ in the
Basal Compartment of the Cell via a Process Involving
Src but Not CAMK II. T.L. Thai, L. Yu, M.M. Wu, L.I.
Galarza-Paez, B.J. Duke, O. Al-Khalili, H. Ma, D.C.
Eaton. Emory Univ. (741.3)
12:00 Lack of Adenylyl Cyclase 6 Induces Alkalosis and
Enhances Urinary Acidification. S.B. Poulsen, R.A.
Fenton, T. Rieg. Aarhus Univ., Denmark, VA San
Diego Healthcare Syst. and UCSD. (741.6)
12:15. (Pro)Renin Receptor Mediates Antidiuretic Action of
Vasopressin/Prostaglandin EP4 Subtype. T. Yang,
X. Lu, K. Peng, F. Wang. Univ of Utah. (741.5)
EB 2016?
66
SUNDAYPHYSIOLOGY
202. THE SPINAL CONTROL OF MOTOR OUTPUT:
FROM NEURAL CIRCUITS TO MECHANICS
Symposium
204. HUGH DAVSON DISTINGUISHED LECTURESHIP
OF THE APS CELL AND MOLECULAR
PHYSIOLOGY SECTION
(Sponsored by: APS Central Nervous System Section)
Lecture
Physiology Section)
Chaired: A. Frigon and T.R. Nichols
Neurobiology
Neurophysiology
10:30 Start and Stop: A Matter of Excitation. O. Kiehn.
Karolinska Inst.
11:00 Reverse Engineering of Motor Output to Identify
the Synaptic Organization of Motor Commands.
C. Heckman. Northwestern Univ.
11:30 The Spinal Control of Left-Right Coordination from
Simple to Extreme Conditions. A. Frigon. Univ.
of Sherbrooke.
12:00 Locomotor CPG and Speed-Dependent Gait Control:
Insights from Computational Modeling. I. Rybak.
Drexel Univ.
GPCRomics: Discovering New Ways Cells Communicate
with One Another and the Outside World. P. Insel. UCSD.
205. CHEMICAL CONTROL OF AUTONOMIC
FUNCTION IN HEALTH AND DISEASE
Featured Topic
(Sponsored by: APS Hypoxia Group)
Chaired: H. Forster and C. Muere
203. WIGGERS AWARD FEATURED TOPIC
Oxidative Stress
Featured Topic
Neurobiology
Chaired: G. Meininger
10:30 Tandem Regulation of Vascular Smooth Muscle
Contraction with Adhesion. G. Meininger. Univ. of
Missouri, Columbia.
11:00 Mechanisms for Aortic Stiffness and Consequent
Cardiovascular Disease with Aging. K. Morgan.
Boston Univ.
11:30 Smooth Muscle Cell Mineralocorticoid Receptors in
Vascular Fibrosis and Aging. I. Jaffe. Tufts Med. Ctr.,
Tufts Univ. Sch. of Med.
12:00 Coronary Microvascular Smooth Muscle-Endothelial
Cell Communication and Notch 3 Signaling in Type
2 Diabetes. P.E. McCallinhart, O.E. Clark, M. Kanai,
B. Lilly, A.J. Trask. Nationwide Children’s Hosp. and
The Ohio State Univ. Col. of Med. (730.3)
12:15 A Splice Variant of Smooth Muscle Myosin Phosphatase
Regulatory Subunit Tunes Arterial Reactivity and
Suppresses Response to Salt Loading. J. Reho,
D. Kenchegowda, L.D. Asico, S. Fisher. Univ. of
Maryland Sch. of Med. (730.1)
Hypertension
3:15 Lahiri-Cherniack Lecture Human Adaptability to
Hypoxia: A Mixed Blessing. J. Dempsey. Univ.
4:00
The Effect of Obese Levels of Leptin on Peripheral
Chemoreception. R.L. Pye, A. Roy, R.J.A. Wilson,
C.N. Wyatt. Wright State Univ. and Univ. of Calgary,
Canada. (983.1)
4:15
Characterization of Ectonucleotidase Expression in the
Rat Carotid Body: Potential Regulation by Hypoxia?
S. Salman, C. Vollmer, C.A. Nurse. McMaster Univ.,
Canada. (983.2)
4:30
Early Postnatal Exposure to Intermittent Hypoxia Results
in Significant Alterations in White Matter Integrity in a
Rat Pup Model of Apnea of Prematurity. R. Darnall, X.
Chen, C. Sirieix, L. Xia, B. Gimi. Dartmouth Geisel
4:45 Chronic Intermittent Hypoxia Suppresses Adult
Neurogenesis and Disrupts Synaptic Plasticity in
the Dentate Gyrus of the Hippocampus through a
Pro-oxidant State. C.M. Pagan, M.A. Khuu, A.Z.
Christakis, J-M. Ramirez, A.J. Garcia III. Seattle
Children’s Res. Inst. and Univ. of Washington. (983.4)
5:00 An Acute Sustained Hypoxic Stress Is Sufficient to
Cause Respiratory Muscle Weakness in the Mouse.
A.J. O’Leary, K.D. O’Halloran. Univiversity Col.
Cork, Ireland. (983.5)
67
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206. COMPARATIVE AND EVOLUTIONARY
PHYSIOLOGY TRAINEE-DRIVEN
FEATURED TOPIC
Featured Topic
207. EARLY LIFE STRESS AND SEX-SPECIFIC
MANIFESTATIONS OF CARDIO-RESPIRATORY
DYSFUNCTION: INSIGHT FROM
MICROGLIAL CELLS
Symposium
(Sponsored by: APS Comparative and Evolutionary
Physiology Section)
Ballroom 20A
Chaired: C. Baldy and J.H. Dasinger
Chaired: D. Warren and C. Ivy
3:15 Ecologically-Relevant Temperatures and Stress
in Desert Pupfish. A. McKenna, K. McKenna,
S. Hillyard, F. van Breukelen. Univ. of Nevada, Las
Vegas. (1229.4)
3:30 Spinal Oxygen Sensors in Larval Amphibians.
I.J. Evanger, M.D. Reed, R.J.A. Wilson,
M. Dutschmann, B.E. Taylor, M.B. Harris. Univ. of
Alaska Fairbanks, Univ. of Calgary, Canada and Univ.
of Melbourne. (1230.2)
3:45
Relative Blood Flow and Cardiac Output in Embryos of
the Snapping Turtle Chelydra serpentina (Reptilia;
Chelonia). M.R. Sartori, Z.F. Kohl, A.S. Abe, E.W.
Taylor, D.A. Crossley II. São Paulo State Univ., Rio
Claro, Univ. of North Texas and Univ. of Birmingham,
U.K. (1230.6)
4:00 Benefits of Being Small? The Scaling of Flight
Performance in Stingless Bees and Size-Dependent
Scaling of Insect Flight Metabolism. M. Duell, J.F.
Harrison. Sch. of Life Sci., Arizona State Univ.
(760.14)
4:15
Amino Acids as Fates of Anoxia-Induced Lactate Loads
in the Painted Turtle. C.A. Hill, K.E. Yarasheski,
D.E. Warren. Saint Louis Univ. and Sch. of Med.,
Washington Univ. St. Louis. (760.19)
4:30 Elevated Carbon Monoxide Production in Marine
Mammals. M.S. Tift, J. St. Leger, T. Leuker, P.J.
Ponganis. Scripps Instn. of Oceanography and
SeaWorld, La Jolla. (760.26)
4:45
Deiodinase Type 3 Methylation Increases in Response
to Thyroid Stimulating Hormone in a Fasting Adapted
Mammal. B. Martinez, N. Gemmell, D.E. Crocker,
R.M. Ortiz. Univ. of California Merced, Univ. of Otago,
New Zealand and Sonoma State Univ. (760.28)
5:00 Respiratory Adaptations to High-Altitude Hypoxia
in Deer Mice (Peromyscus maniculatus). C. Ivy,
G. Scott. McMaster Univ., Canada. (1230.3)
Visit the Exhibits
April 3–April 5
Exhibit Hours
Sunday–Tuesday
9:00 AM–4:00 PM
68
Sex Differences
Exercise, Aging, and Disease
Hypertension
3:15
Do Sex Differences in Microglia in the Brain Impact
Somatic Functions? M. McCarthy. Univ. of Maryland
Sch. of Med.
3:45 Sex Differences in Hypertension: Menopause,
T Lymphocytes and Inflammation. H. Brooks. Univ.
of Arizona.
4:15 The Impact of Sex and Age on the Developmental
Programming of Blood Pressure. B. Alexander. Univ.
of Mississippi Med. Ctr.
4:45 Neonatal Stress and Sex-Specific Disruption of
Respiratory Control Development: The Potential Role
of Microglia. R. Kinkead. Laval Univ.
208. EMERGING MECHANISMS OF
THERMOREGULATION AND
METABOLIC CONTROL
Symposium
(Sponsored by: APS Environmental and Exercise
Physiology Section)
Chaired: T.L. Clanton and M. Periasamy
Environmental Stress
3:15 Hot and Sweet: Human Brown Fat beyond
Thermoregulation. P. Lee. Garvin Inst. Med. Res.,
Darlington, NSW, Australia.
3:45
Muscle Beyond Contraction, Its Role in Thermogenesis
and Metabolism. M. Periasamy. Sanford Burnham
Prebys Medical Discovery Inst.
4:15
Which TRP Channels Drive Cold-Defense Responses
in Rodents? A. Romanovsky. St. Joseph’s Hosp. and
Arizona State Univ.
4:45
Exercise and Neurodegeneration; Potential Therapeutic
Role for FNsDC5/irisin. C. Wrann. Dana Farber Inst.,
Harvard Univ. Med. Sch.
SUNDAYPHYSIOLOGY
209. INTERMITTENT HYPOXIA: RESPIRATORY AND
CARDIOVASCULAR CONTROL AND BEYOND
4:15
4:45
Featured Topic
212. SEX DISPARITIES IN CARDIOVASCULAR
FUNCTION AND REMODELING
Chaired: I.C. Solomon and D. Fields
3:15
3:45
4:15
4:30
4:45
5:00
Intermittent Hypoxia: A Low Risk Research Tool with
Therapeutic Value in Humans. J. Mateika. Wayne
State Univ.
Modulation of Lower Urinary Tract (LUT) Function by
Acute Intermittent Hypoxia. W. Collins III. Stony
Brook Univ.
Hypoxia Hits below the Diaphragm: Effect of Acute
Hypoxia on the Micturition Reflex. M. Catege, I.C.
Solomon, W.F. Collins. Stony Brook Univ. (986.1)
Pretreatment with Ampakine CX717 Enhances LongTerm Facilitation of Inspiratory Hypoglossal (XII)
Bursting, but Only When Initial Burst Output Is Low.
S. Turner, M. Elmallah, A. Hoyt, J. Greer, D. Fuller.
Univ. of Florida and Univ. of Alberta. (986.3)
Antioxidant and Angiotensin AT1 Receptor Antagonist
Treatment Reduced the Hypertension Induced by
Chronic Intermittent Hypoxia in Rats, but Had Different
Effects on Endothelial Dysfunction. R. Iturriaga, B.
Krause, P. Casanello, A.C.R. Dias, P. Arias, R. Del
Rio. Pontifical Catholic Univ. of Chile. (986.4)
Chronic Intermittent Hypoxia Altered Stability of Rhythm
Generation but Increased Robustness of Respiratory
Network. T. Dashevskiy, A.J. Garcia III, J-M.
Ramirez. Seattle Children’s Res. Inst. and Univ. of
Washington. (986.5)
210. MICROCIRCULATORY SOCIETY LANDIS
AWARD LECTURE
Featured Topic
(Sponsored by: APS Cardiovascular Section and AJP:
Heart and Circulatory Physiology)
Chaired: S. Goulopoulou
Sex Differences
3:15
3:45
4:15
4:30
4:45
5:00
How does Blood Flow Know Where to Go? S. Segal.
Univ. of Missouri, Columbia.
Symposium
Regulation Section)
Symposium
3:15
3:45
Sex-Based Differences in Non-Genomic Vascular
Signaling. M. Hamblin. Tulane Univ.
Inflammation and Extracellular Matrix Differences
in Male and Female Aging in Mice. Y. Ma. Univ. of
Gender Differences in Cardiomyocyte Adhesion Cause
Heart Failure. G.L. Brower, Y. Du, E. Plante, J.A.
Stewart; Jr., J.S. Janicki. Texas Tech Univ. Hlth. Sci.
Ctr., Univ. of South Carolina, Univ. of Montreal and
Mississippi State Univ. (738.11)
Obesity-Associated Impairments in Autonomic Control
of Blood Pressure and Heart Rate Are Sex-Specific.
T. Bruder-Nascimento, O.J. Ekeledo, R. Anderson,
H.B. Le, E.J. Belin de Chantemele. Med. Col. of
Georgia at Augusta Univ. (738.5)
Sex-Specific Transcriptomic Regulation in the Diseased
Human Heart. G. Kararigas, H. Summer, I. Baczko,
S. Golz, V. Regitz-Zagrosek. Charité Univ. Hosp.,
Berlin, Bayer Hlth.Care, Wuppertal, Germany and
Univ. of Szeged, Hungary. (738.9)
Hypertension and Type II Diabetes Are Not Associated
with Visceral Inflammation or Vascular Remodeling/
fibrosis in Obese Women. R. Fernandes, G.D. Fink,
J.J. Galligan, S.W. Watts, C. Pereira-Hicks, R.E.
Watson, H. Xu. Michigan State Univ. (738.6)
213. THE BRAIN-GUT AXIS: MICROBIOME IN
NEURAL AND METABOLIC DISEASES
211. ORAI/STIM1 PHYSIOLOGY
AND PATHOPHYSIOLOGY
Physiology Section)
Chaired: J. Zubcevic and M.K. Raizada
Neurobiology
Chaired: S. Muallem and E. Delpire
Hypertension
Ion Transport
Microbiome
Orai/STIM1 Function and Cancer. N. Prevarskaya.
Univ. of Sci. and Tech. of Lille, France.
Orai/STIM1 Function in the Immune System. S. Feske.
New York Univ. Sch. of Med.
S
U
N
Lecture
The Other Orai Channels in Smooth Muscle Function.
M. Trebak. Albany Medical Col.
Gating Orai1/STIM1 by PIP2 Microdomains and
Pancreatic Function. S. Muallem. NIDCR, NIH.
3:15
The Microbiota-Gut-Brain Axis in Health and Disease.
J. Cryan. University Col. Cork, Ireland.
3:45
The Gut Microbiota and the Vagal Afferent Pathway - From
Bugs to Brain. H. Raybould. Univ. of California Davis.
4:15 Gut Microbiome Influences Blood Brain Barrier
Permeability in Mice. S. Pettersson. Karolinska Inst.
69
PHYSIOLOGYSUNDAY
4:45
Gut Dysbiosis is Linked to Hypertension. M. Santisteban.
Univ. of Florida.
214. WEH NEW INVESTIGATOR AWARD LECTURE
216. ERNEST H. STARLING DISTINGUISHED
LECTURESHIP OF THE APS WATER AND
ELECTROLYTE HOMEOSTASIS SECTION
Lecture
Lecture
Blood Pressure and Fluid Volume Regulation in Pregnancy.
E. George. Univ. of Mississippi.
215. WHAT DO BOTH MITOCHONDRIAL PROTEIN
TURNOVER AND MITOCHONDRIAL FUNCTION
TELL US ABOUT EXERCISE AND AGING?
Time to Re-think Sodium Homeostasis? D. Pollock.
Univ. of Alabama at Birmingham.
216A.APS UNDERGRADUATE POSTER SESSION AND
BRUCE AWARDS
Poster Discussion
Sun. 4:00 pm—San Diego Convention Center, Sails Pavilion
Featured Topic
Physiology Section)
217. MICROCIRCULATORY SOCIETY BUSINESS
MEETING AND RECEPTION
Business Meeting
Chaired: B. Miller
(Supported by Microcirculatory Society)
3:15
What Does Mitochondrial Protein Turnover Tell Us
about Exercise and Aging? K. Hamilton. Colorado
State Univ.
3:45 What Does Mitochondrial Function Tell Us about
Exercise and Aging? R. Boushel. Swedish Sch. of
Sport and Hlth. Sci., Stockholm.
4:15
Effect of Partial Denervation Mitochondrial ROS Generation
in Skeletal Muscle. N. Pollock, C.A. Staunton, A.Vasilaki,
A. McArdle, M. Jackson. Univ. of Liverpool. (764.1)
4:30 Exercise Training Induced Regulation of Muscle
Mitochondrial Dynamics. D.K. Fix, J.P. Hardee, S. Gao,
K.L. Hetzler, J.A. Carson. Univ. of South Carolina. (764.2)
4:45 Parkin-Mediated Mitophagy in Skeletal Muscle with
Aging and Exercise. C. Chen, D. Hood. Sch. of
Kinesiol. and Hlth. Sci., York Univ., Canada. (764.3)
5:00
Anabolic Response to Exercise Is Not Limited in Older
Adults Despite Lower Mitochondrial Respiratory
Capacity Compared to Young. I. Lanza, A. Lalia, S.
Dasari, M. Robinson, H. Abid, D. Morse, K. Klaus.
Mayo Clin. (764.4)
218. HENRY PICKERING BOWDITCH AWARD LECTURE
Lecture
Ballroom 20A
Sodium-Sensing Central to Salt-Sensitive Hypertension.
S. Stocker. Penn State Col. of Med.
70
MONDAY, APRIL 4
Across Societies
219. NIH K AWARDS
Seminar
Mon. 9:00 am—San Diego Convention Center,
Exhibit Hall D
NIH Grants Seminar
Career Development
This presentation, by Dr. Henry Khachaturian of NIGMS, NIH,
will focus on the NIH’s new K99/00 Pathways to Independence
Award (for postdoctoral scientists) and the K08 Mentored Clinical
Scientist Development Award (for individuals with a health
professional doctoral degree committed to a career in laboratory
or field-based research). The interactive discussion will give
attendees an opportunity to ask questions of and obtain insight
from an NIH representative.
220. NIH FELLOWSHIP (F) AWARDS
Seminar
Mon. 1:00 pm—San Diego Convention Center, Exhibit
Hall D
NIH Grants Seminar
Career Development
This presentation, by Dr. Henry Khachaturian of NIGMS,
NIH, will focus on the NIH’s Ruth L. Kirschstein National Research
Service Awards (NRSA). The NRSA research training fellowship
(F) awards are targeted to individuals with or seeking research
doctoral degrees (Ph.D. and equivalent) and clinical doctoral
degrees (M.D. and equivalent). Among the F awards discussed
will be the F30, NRSA Individual Predoctoral MD/PhD or Other
Dual-Doctoral Degree Fellowship Award, the F31 NRSA Individual
Predoctoral Fellowship, the F31 NRSA Individual Predoctoral
Fellowship to Promote Diversity in HealthRelated Research
Award, the F32 NRSA Individual Postdoctoral Fellowship Award,
and the NRSA Individual Senior Fellowship Award. The interactive
discussion will give attendees an opportunity to ask questions
of and obtain insight from an NIH representative on these and
other awards available for pre- and postdoctoral fellows and
senior investigators.
Handouts and resource materials will be provided on-site.
9:00
Job Search in Academia & Industry. D. Behrens. Univ.
of California, Berkeley.
9:00
Building Your Skills, Networking & Information Interview.
A. Green. Univ. of California, Berkeley.
9:00
Goal Setting, Prioritizing, Time & Stress Management.
H. Adams. H.G. Adams & Assocs. Inc., Norfolk, VA.
Practices: Publication Practices & Authorship,
Conflicts of Interest, and Research. S. Sodeke, T.
10:30 One Package: Your Resume, Interview and Job.
10:30 How to Choose Your Ideal Career. B. Lindstaedt. UCSF.
10:30 Selling Yourself to the Life Sciences Industry. J. Tringali.
Tringali & Assocs. Inc.
11:00 Developing Your Core Message/ “Elevator Pitch”.
J. Lombardo. Med. Col. of Wisconsin and
Marquette Univ.
1:00
Translating Your Credentials on Paper (CV=>Resume)
& In Person. A. Green. Univ. of California, Berkeley.
1:00
Job Hunting in Biotech Part 1: Finding & Applying for
1:00 Successful Behaviors for Winning an Interview.
1:00 Responsible Conduct of Research Part 1: Historical
Perspectives: Past Controversies, Successes, and
Present Challenges. S. Sodeke, T. Turner. Tuskegee
Univ., Jackson State Univ.
2:15
Beyond the Bench: Preparing for Your Career Transition
in the Life Sciences. J. Tringali. Tringali & Assocs. Inc.
2:30 Handshakes, Eye Contact, Small Talk: How to
Successfully Network at a Conference. N. Saul. UCSF.
2:30
3:30 The Strategic Postdoc: How to Find & Leverage
Your Postdoc Experience. A. Green. Univ. of
3:30 Overcoming Communication Barriers in the Grad
Research Lab. H. Adams. H.G. Adams & Assocs.
Inc., Norfolk, VA.
4:00 Transforming Your CV/Cover Letter for Industry
Positions. N. Saul. UCSF.
4:00 Attitudes and Behaviors: How are you Perceived?
71
M
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ANATOMYMONDAY
Anatomy
222. MECHANOTRANSDUCTION IN DISEASE
Minisymposium
Minisymposium
(In collaboration with The Biomedical Engineering Society)
(In collaboration with The Biomedical Engineering Society)
Mon. 8:30 am—San Diego Convention Center, Room 9
Cochaired: S. Simon and G. Schmid-Schoenbein
Chaired: S. Li
Cardiovascular Biology
This session is part of the Tissue Mechanics & Morphogenesis
Mini-Meeting
8:30 222.1
The Epigenomic Code in Hemodynamic
Regulation of Cell Phenotypes in Atherosusceptible
Endothelium. P.F. Davies. Univ. of Pennsylvania.
9:00 222.2
Dysfunctional Mechanosensing of Extracellular
Matrix in Thoracic Aortic Disease. J.D. Humphrey. Yale Univ.
9:30 222.3
Mechanical
Signaling
in
EpithelialMesenchymal Transition. A. Engler, J. Yang, M. Ondeck,
S. Wei. UCSD.
223. THE FATE OF THE CHONDROCYTE
IN DEVELOPMENT, REGENERATION,
AND DISEASE
Symposium
Chaired: R. Marcucio
10:30 223.1
Transdifferentiation of Chondrocytes to
Osteoblasts during Bone Fracture Healing. R. Marcucio, D.
Hu, F. Yang, C. Bahney, T. Miclau. UCSF and Orthopaed.
Trauma Inst., San Francisco.
11:00 223.2
Genetic Control of Hypertrophic Chondrocyte
to Osteoblast Differentiation in Development and Skeletal
Disorders. K. Cheah, T. Au, S. Wynn, T. Tan, R. Yip, D. Chan.
Sch. of Biomed. Sci., The Univ. of Hong Kong and Univ.
of Melbourne.
11:30 223.3
Direct Transformation of Chondrocytes into
Bone Cells: Outside of the Box. J. Feng. Texas A&M Univ.
Baylor Col. of Dent.
72
224. MECHANICS OF THE CARDIOVASCULAR SYSTEM
Mini-Meeting
10:30 224.1
Systems
Mechanobiology
and
Multiscale Modeling of Ventricular Hypertrophy and Failure.
A.D. McCulloch, K. Buchholz, P.Tan, S. Dewan, J. Saucerman,
J.H. Omens, V. Nigam. UCSD and Univ. of Virginia.
11:00 224.2
Cardiac Mechanics, Hemodynamics, and
Embryonic Heart Development. S. Rugonyi. Oregon Hlth. &
Sci. Univ.
11:30 224.3
Integrating Light-Sheet and Hemodynamic
Forces to Elucidate Cardiac Development, Injury and Repair.
T. Hsiai. UCLA.
225. ANATOMY EDUCATION PLATFORM 1
Platform
Cochaired: M. Hortsch and C. Krebs
Adapting the Anatomical Sciences to Changing Curricula:
Ideas, Tools and Validation
10:30 225.1
The Effectiveness of Self-Paced Activities for
Anatomy Instruction in a Case-Based Medical Curriculum.
B. Szymik, D.W. Hesse. GRU/UGA Med. Partnership.
10:45 225.2
No Longer a Novelty: Formalizing UltrasoundBased Activities in Gross Anatomy through Objective Structural
Practical Examination. T.R. Blankers, N. Lachman, A. Bhagra,
W. Pawlina. Mayo Med. Sch. and Mayo Clin. Col. of Med.
11:00 225.3
X-perience – an Interactive Viewing Platform
Displaying Radiographic Profiles of Cadavers for Educational
Purposes. E. Nic an Riogh, G.F. Perry, J.F..X. Jones,
A. Tattersall, M. Heduan, R.H. Stern, P. MacMahon, N.
Giannotti, M. Davis. University Col. Dublin Sch. of Med.,
Mount Sinai Hosp., NY and Mater Misericordiae Univ. Hosp.,
Dublin. (568.23)
11:15 225.4
Microscopic
Anatomy
and
Pathology
Laboratories: Design of an e-Learning Atlas as an Evolving
Response to Interdisciplinary Medical Curricular Needs.
R.A. Jurjus, J. Wade, V. Moktan, M.S. Davis, A. Mills, G. Butera,
J. Krum, P. Latham. George Washington Univ. Sch. of Med.
11:30 225.5
Emphasizing the Importance of Qualitative
Research in Anatomy Education: A “How-to-Guide” on Case
Study Design, Implementation, and Data Analysis. C.J. Traser.
Indiana Univ. Sch. of Med.
MONDAYANATOMY
11:45 225.6
Divide and Conquer: On Demand Anatomy in
the Medical School Curriculum. M. Rosenberg, R. Hartley.
Univ. of New Mexico Sch. of Med.
226. CELL BIOLOGY AWARD HYBRID
Hybrid Symposium
Mon. 10:30 am—San Diego Convention Center, Room 7B
3:20 227.5
Phantageusia: The Presence of Taste
Distortions Inhibited by Repetitive Transcranial Magnetic
Stimulation. R.I. Henkin, M. Abdelmeguid, A.B. Knoppel, S.J.
Potolicchio. The Taste and Smell Clin., Washington, DC and
George Washington Univ. Med. Ctr.
228. MOLECULAR MECHANISMS OF TISSUE
DYNAMICS
Chaired: A. Lysakowski
Minisymposium
Cell Biology
Mon. 2:00 pm—San Diego Convention Center, Room 9
Chaired: J.A. Guttman
R.R. Bensley Award Lecture in Cell Biology featuring 2016
Young Investigator Award Recipient, Andrew Holland. Dan
Georgess is competing as a finalist in the Postdoctoral Platform
Presentation Award and Sahithi Pamarthy is competing as a
finalist in the Langman Graduate Platform Presentation Award
10:30 226.1
Deciphering How Cells Count: Molecular
Control of Centrosome Copy Number. A. Holland, T. Moyer,
B. Lambrus, M. Levine, K. Clutario, P. Scott, V. Daggubati.
Johns Hopkins Univ. Sch. of Med.
11:00 226.2
The Nature of Nurture: Investigating the
Role of Notch Signaling and Vacuolar ATPase in Mammary
Gland Development. S. Pamarthy, L. Mao, G.K. Katara, M.K.
Jaiswal, A. Kulshrestha, A. Gilman-Sachs, K.D. Beaman.
Rosalind Franklin Univ. of Med. and Sci.
11:15 226.3
Twist1 Triggers PKD1 Expression to Promote
Metastatic Dissemination in Breast Cancer. D. Georgess,
O.K. Sirka, N.M. Neumann, E.R. Shamir, A.J. Ewald. Johns
Hopkins Univ. Sch. of Med.
11:30 226.4
Cyclophilin A Is Crucial for Listeria and
Salmonella Invasion and Cell-to-Cell Spreading. A. Dhanda,
K. Warren, J. Guttman. Simon Fraser Univ., Canada.
11:45 226.5
Initiation of Smell in Congenital Smell Loss.
R.I. Henkin, M. Abdelmeguid, A.B. Knoppel. The Taste and
Smell Clin., Washington, DC.
Mini-Meeting
2:00 228.1
Molecular Asymmetries in Actin Dynamics
Drive Left-Right Organogenesis. L.A. Trinh, E. Koo, V. Trivedi,
M. Bagnat, S.E. Fraser. Univ. of So. California, Caltech and
Duke Univ.
2:30 228.2
Molecular Engineering for Imaging and
Reprogramming in Live Cells. P.Y. Wang, J. Sun, L. Lei. UCSD
and Univ. of Illinois at Urbana-Champaign.
3:00 Three-Dimensional Quantitative Delineation
of Spatially Heterogeneous Metastasis Landscape. S. Zhang.
Univ. of Notre Dame.
229. EDUCATIONAL RESEARCH STUDENT
PLATFORM AWARDS SESSION
Award Competition
Chaired: J. Mussell
227. CLINICAL APPROACH IN MORPHOLOGICAL
RESEARCH
Hybrid Symposium
(Cosponsored by: Brazilian Society of Anatomy)
Student and Postdoc award finalists present oral
presentations to compete for the Education Platform Award
2:00
Chaired: V.P.S. Fazan
Neurobiology
2:15
2:00 227.1
Experimental Evidence of a Hypertensive
Neuropathy: Is It a New Disease?. V.S. Fazan. Univ. of São Paulo.
2:40 227.2
Aortic Depressor Nerve Morphology in Developing
Spontaneously Hypertenvie Rats. M.M. Amorim, J.A. Castania,
H.C. Salgado, V.P.S. Fazan. Sch. of Med. of Ribeirão Preto, Brazil
2:50 227.3
Transcutaneous Vagus and Trigeminal Nerve
Stimulation for Neuropsychiatric Disorders: Underscoring
Anatomical Landmarks and Connections. M.D. Barros, A.
Trevizol, I. Sato, B.M. Liquidato, Q. Cordeiro, P. Shiozawa.
Santa Casa de São Paulo Sch. of Med. Sci.
3:10 227.4
Fos-Immunoreactive Neurons in Rat Intrinsic
Cardiac Ganglia after Pericardial Capsaicin Injection. T. Wang,
K.E. Miller. Oklahoma State Univ. Ctr. for Hlth. Sci.
2:30
2:45
Examination of the Roles of Learning Style and Learning
Strategy on the Academic Performance of First Year
Medical Students. C.T. Nichols, A.C. Edmondson.
Med. Col. of Georgia at Augusta Univ. (569.5)
The Influence of Spatial Ability on Medical Student
Performance in the Basic Sciences. A. Willis, A.
Edmondson, C. Martin. Med. Col. of Georgia at
Augusta Univ., Augusta Univ. and Univ. of Western
Ontario. (570.5)
Preliminary Results of a National Survey on the
Integration of Anatomical Variations in Medical School
Curricula. C. Goldberg, D. Royer. Univ. of Colorado
Anschutz Med. Campus. (369.6)
Problem Sets Allow for Multiple Competency Acquisition
in First Year Neuroscience Course. M.D. Lameka,
W.G. Pearson, A.C. Edmondson. Med. Col. of
Georgia at Augusta Univ. (569.13)
73
M
O
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ANATOMYMONDAY
3:00
3:15
Gross Anatomy Dissection Improves Exam Scores
Amongst Medical and Allied Health Students.
R.J. Anders, A.C. Edmondson, C.M. Martin, K.
Wheeler. Med. Col. of Georgia - Augusta Univ. and
Western Univ., Canada. (567.8)
A Cadaveric Procedural Anatomy Course Enhances
Operative Competence. G. Sharma, M.A. Aycart, T. van
Houten, D.S. Smink, R. Askari, J.D. Gates. Brigham
and Women’s Hosp., Harvard Med. Sch. (567.7)
230. THE WIDE WORLD OF CORONARY ANOMALIES:
INSIGHT FROM THE CLINIC AND THE LABORATORY
232. TISSUE CONTRACTILITY AND MORPHOGENESIS
Minisymposium
Chaired: A. Czirok
Symposium
Mon. 2:00 pm—San Diego Convention Center, Room 7B
Chaired: M. Watanabe
Cell Biology
2:00
2:05 230.1
Non-invasive Evaluation of Anomalous Aortic
Origin of Coronary Arteries and Surgical Management.
R. Ashwath, D. Prasad. Case Western Reserve Univ.
2:30 230.2
Newer Concepts in Coronary Artery Anomalies,
Based on Accurate In Vivo Imaging (IVUS). P.E. Angelini, C.E.
Uribe. Texas Heart Inst., Houston.
3:00 230.3
CXCL12 and Vascular Maturation of the
Coronary System during Heart Development. S. Cavallero,
H. Shen, C. Yi, R.K. Subramanyan, H. Sucov. Univ. of So.
California Keck Sch. of Med. (554.5)
231. MORPHOLOGICAL SCIENCES AWARD HYBRID
Hybrid Symposium
Chaired: R. Daneman
Morphological Sciences Award Lecture featuring 2016 Young
Investigator Award Recipient, Casey Holliday. Colin Moore,
Gillian Corbo and John Merlo are competing as finalists in the
Langman Graduate Platform Presentation Award
4:00 231.1
Exploring Cranial Functional Morphology and
Evolution through the Jaws of Alligators. C.M. Holliday. Univ.
4:30 231.2
Ontogenetic Cranial and Postcranial Regional
Variation in Bone Strength: Comparisons in Two Archaeological
Populations. E.M. Garofalo, M.A. Holmes. Univ. of Arizona
Col. of Med. and Sch. of Med., Duke Univ. (779.18)
4:45 231.3
Functional Anatomy of the Palmaris Brevis:
Grasping for Answers. C.W. Moore, C.L. Rice. Sch. of Kinesiol.
Aad Schulich Sch. of Med. and Dent., Univ. of Western Ontario.
5:00 231.4
The Anterolateral Ligament and the Lateral
Meniscus’ Synergistic Contribution to Rotational Knee Stability. G.G.
Corbo,T. Lording,T. Burkhart, M. Johnson, A. Getgood. Western
Univ., Canada and Melbourne Orthopaed. Gp., Windsor, Australia.
74
5:15 231.5
Onset and Progression of Facet Joint Articular
Cartilage Degeneration following Lumbar Spinal Hypomobility.
J.A. Merlo, C. Lawson, J.A. McDowell, A.N. Benckendorf,
G.D. Cramer, J.W. Little. Saint Louis Univ. Sch. of Med. and
Doisy Col. of Hlth. Sci. and Natl. Univ. of Hlth. Sci., IL.
Mini-Meeting
4:00 232.1
Self-Organizing Actomyosin Patterns on the
Cell Cortex at Epithelial Cell-Cell Junctions. Z. Neufeld. Univ.
of Queensland, Australia.
4:30 232.2
Let There Be Force: Modeling Cell-ECM
Interactions during Cancer Invasion. Y. Jiang. Georgia
State Univ.
5:00 232.3
The Role of Cell Contractility in Epithelial
Morphogenesis. C.M. Nelson, V.D. Varner. Princeton Univ.
233. MACROPHAGES: WHAT ARE WE “SEEING” AND
WHAT ARE WE MISSING?
Symposium
Chaired: B. Singh
Cell Biology
4:00 233.1
A New Look at the Alveolar Macrophage.
J. Bhattacharya. Columbia Univ. Med. Ctr.
4:30 233.2
Imaging the Role of Macrophage in Infection
and Sterile Injury in Liver. P. Kubes, Z. Zeng, C. Jenne. Univ.
of Calgary, Canada
5:00 233.3
Intravital Microscopy Identifies Macrophages
As Effector Cells for Monoclonal Antibody Therapy of Cancer.
M. van Egmond. VU Univ. Med. Ctr., Amsterdam.
234. AAA MEMBERS MEETING
Business Meeting
All AAA Members are encouraged to attend (formerly called
the AAA Business Meeting)
235. GRADUATE STUDENT/POSTDOC
POSTER RECEPTION
Poster Discussion
Mon. 6:00 pm—San Diego Convention Center,
West Terrace Lobby
MONDAYBIOCHEMISTRY
236. ASBMB PLENARY LECTURE
Award Lecture
8:00
8:05 236.1
Illuminating Biology at the Nanoscale with
Single-Molecule and Super-Resolution Imaging. X. Zhuang.
Harvard Univ., HHMI.
Plenary
8:45
8:50 237.1
Functionalizing the Unannotated Mitochondrial
Proteome. J.P. Rutter. HHMI, Univ. of Utah.
238. ALICE AND C.C. WANG AWARD IN MOLECULAR
PARASITOLOGY SYMPOSIUM
Award Lecture
Mon. 9:45 am—San Diego Convention Center, Room 1A
9:45
9:50 238.1
Translating the Trypanosome Surface.
M.A.J. Ferguson, M.L.S. Güther. Sch. of Life Sci., Univ. of
Dundee, U.K.
10:30 238.2
Tracking the In Vivo Dynamics of Antigenic
Variation in Trypanosoma brucei. M. Mugnier, G.A.M. Cross,
F.N. Papavasiliou. The Rockefeller Univ.
11:00 238.3
Carbon Metabolism of Parasitic Protozoa:
Strategies for Surviving in Intracellular Niches. M. McConville,
E. Saunders, F. Sernee, M. Blume, J. Kloehn, J. Ralton. Univ.
of Melbourne.
11:30 238.4
A Clinical Candidate Targeting Dihydroorotate
Dehydrogenase for the Treatment of Malaria with Blood
and Liver Stage Activity. M.A. Phillips, S.A. Charman, P.K.
Rathod, J. Burrows, T. Rueckle. Univ. of Texas Southwestern
Med. Ctr., Monash Inst. of Pharmaceut. Sci., Australia, Univ. of
Washington and Meds. for Malaria Venture, Geneva.
239. REGULATION OF RECOMBINATION
Symposium
Chaired: C. Kisker
9:45
9:50 239.1
Regulation of Homologous Recombination:
Robustness through Reversibility. W-D. Heyer. Univ. of
California, Davis.
10:15
Live Cell Interrogation of dCas9:sgRNA
Dynamics off and at the Target. T. Pederson. Univ. of
Massachusetts Med. Sch. (571.1)
10:30 239.2
Dissecting the Role of the Rad51 Paralogs
during Double-Strand Break Repair. K. Bernstein, T.B.
McClendon, M.R. Sullivan, S.K. Godin, W. Gaines, P. Sung,
J. Yanowitz. Univ. of Pittsburgh Sch. of Med. and Yale Univ.
10:55
Estrogen Induces RAD51C Expression and
Localization to Sites of DNA Damage. M.K. Holz. Yeshiva
Univ., NY. (799.1)
11:10
Interactomic and Enzymatic Analyses of
Distinct Affinity Isolated Human Retrotransposon Intermediates.
J. LaCava, K.R. Molloy, D. Fenyö, M.S. Taylor, B.T. Chait, J.D.
Boeke, M.P. Rout. The Rockefeller Univ.,NYU Sch. of Med.
and Massachusetts Gen. Hosp. (801.1)
11:25 239.3
The Role of Mammalian Polymerase Theta in
DNA Repair. A. Sfeir. NYU Sch. of Med.
11:50
Discussion.
240. ENZYME DYNAMICS AND ENZYME MOTIONS
Symposium
Mon. 9:45 am—San Diego Convention Center, Room 6C
9:45
9:50 240.1
Observations on the Cellular Dynamics of
a Metabolic Complex, the Purinosome. S. Benkovic, C.Y.
Chan, D. Kim, A. Pedley, X. Zhuang. Penn State and Harvard/
HHMI, Cambridge.
10:15
Large Scale Structural Rearrangement
Provides Dual Control Over the Catalytic and Membrane
Binding Activity of a Bacterial Serine Hydrolase. R.J. Johnson,
M. Smith, W. Hart. Butler Univ. (833.6)
10:30 240.2
NMR Relaxation Dispersion. P. Loria.
Yale Univ.
10:55
Conservative Substitutions of Buried Amino
Acid Residues Distant from the Active Site of Horse Liver
Alcohol Dehydrogenase Have Small Effects on Structure,
Catalysis and Dynamics. B.V. Plapp, K. Shanmuganatham,
R.S. Wallace, A.T-I. Lee. Univ. of Iowa. (833.5)
11:10
Control of Enzyme Function through Loop
Dynamics. C.N. Chi, B. Vogeli, S. Bibow. ETH, Zurich. (835.2)
11:25 240.3
Separated at Birth, the Evolution of Kinase
Dynamics over a Few Billion Years. D. Kern. HHMI,
Brandeis Univ.
11:50
Discussion.
241. BUILDING MOLECULAR MACHINERY
Symposium
Mon. 9:45 am—San Diego Convention Center, Room 6D
Chaired: C.M. Dunham
9:45
9:50 241.1
Molecular Switches in Proteasome Assembly:
Tales of the Tails and Chaperones. S. Park. Univ. of
Colorado Boulder.
10:15
Functional Cooperativity between the Trigger
Factor Chaperone and the ClpXP Degradation System.
W.A. Houry. Univ. of Toronto. (811.6)
75
M
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BIOCHEMISTRYMONDAY
10:30 241.2
Quality Control of Nuclear Pore Complex
Biogenesis. P. Lusk, B. Webster, J. Jaeger, D. Thaller. Yale
Sch. of Med. and Univ. of California Berkeley.
10:55
Illuminating the Proteasome: Fluorescence
Assays for Investigating the Kinetics of Proteasome Substrate
Processing. J.A. Bard, E. Jonsson, A. Martin. Univ. of
California, Berkeley. (597.2)
11:10
Translocating Loop-Substrate Interactions
Mediate
Subunit
Coordination
and
Regulate
the
Mechanochemical Coupling and Power Production in a AAA+
Protease Machine. P. Rodriguez, L. Ramirez, F. Kim, C.
Bustamante, A. Martin. Univ. of California, Berkeley. (595.2)
11:25 241.3
Quality Control in 40S Ribosome Maturation.
K. Karbstein. The Scripps Res. Inst.
11:50
Discussion.
10:30 243.2
Transcriptional Control of Lipid Homeostasis.
P. Totonoz. UCLA.
10:55
HPV16-E7 Oncoprotein Enhances CeramideMediated Lethal Mitophagy by Regulating the Rb/E2F5/Drp1
Signaling Axis. R. Thomas, N. Oleinik, B. Ogretmen. Med.
Univ. of South Carolina. (872.6)
11:10
Cysteinyl Leukotriene 2 Receptor Enhances
Angiogenesis, Vascular Permeability and Tumor Metastasis.
E. Duah, V. Kondeti, N. Al-Azzam, R. Adapala, P. Patil, C.
Thodeti, S. Paruchuri. Univ. of Akron and Northeast Ohio
Med. Univ. (872.4)
11:25 243.3
The Phase of Fat: Mechanisms and Physiology
of Lipid Synthesis and Storage. R.V. Farese, T. Walther.
Harvard Univ., Boston.
11:50
Discussion.
242. MECHANISTICALLY-INFORMED DRUG DESIGN
244. BIOCHEMISTRY AND TODAY’S PREMED STUDENT
Symposium
Mon. 9:45 am—San Diego Convention Center, Room 6E
Symposium
Chaired: J.W. Kozarich
9:45
9:50 242.1
trans-Translation as a Target for Novel
Antibiotics. K. Keiler. Penn State
10:15
Novel Small Molecule, WZB117, Competitively
Inhibit GLUT1-Mediated Glucose Transport to Halt Cancer
Growth. O. Ojelabi, J. DeZutter, K. Lloyd, A. Carruthers.
Univ. of Massachusetts Med. Sch. (1099.1)
10:30 242.2
Identifying Vulnerable Steps in the Coenzyme A
Biosynthesis Pathway of M. tuberculosis. V. Mizrahi, J. Evans,
C. Trujillo, H. Eoh, S. Ehrt, D. Schnappinger, H. Boshoff, K.
Rhee, C.E. Barry III. Univ. of Cape Town, Weill Cornell Med.
Col. and NIAID, NIH.
10:55
Differential Regulation of mTORC1 by Amino
Acids. J.L. Jewell, K-L. Guan. Univ. of Texas Southwestern
Med. Ctr. and UCSD. (1099.18)
11:10
Potent Lipidated Antagonists to ProteaseActivated Receptor 2. S. Boitano, J. Hoffman, A. Flynn, C.L.
Sherwood, Z. Zhang, R. Patek, T.J. Price, J. Vagner. Univ. of
Arizona and Univ. of Texas at Dallas, Richardson. (848.6)
11:25 242.4
Rational
Optimization
of
Natural-Born
Mechanism-Based Inhibitors of the 20S Proteasomes in
Humans and Mycobacterium tuberculosis. J. Sello. Brown Univ.
11:50
Discussion.
243. LIPID SIGNALING
Symposium
Chaired: E. Hodis
9:45
9:50 244.1
MCAT2015: A New Focus on Biochemistry.
S.H. Oyewole. Trinity Washington Univ., Alexandria, VA.
10:15
Creating an Outcomes-Based Biochemistry
Major from ASBMB and ACS Major Guidelines That Reflects
MCAT Needs. J.K. Bell, T.J. Dwyer, C.M. Loer, M.S. Lowery,
J.J. Provost. Univ. of San Diego. (887.2)
10:30 244.2
Transformation
in
Biomedical
Science
Education for Future Physicians. S. Lieberman. Univ. of Texas
Med. Br. Sch. of Med.
10:55
Organic
Chemistry
and
Biochemistry
Curriculum for the New MCAT. Y. Dobrydneva, L. Schwartz.
George Washington Sch. of Med. and Hlth. Sci. (887.1)
11:10
Integration of Biochemistry and Problem
Solving-Based Pedagogy throughout the Chemistry
Curriculum in Support of Learning Outcomes Articulated by the
Association. of American Medical Colleges., the ASBMB and
the American Chem. Soc. H.V. Jakubowski, K. Graham, E.
McIntee, C. Schaller. Col. St. Benedict/St. John’s Univ., MN.
(662.12)
11:25 244.3
A Description of the First Year of the New
MCAT® Exam. M. Kroopnick. Assn. of American Med. Cols.,
Washington, DC.
11:50
Discussion.
Mon. 9:45 am—San Diego Convention Center, Room 6F
Chaired: G.M. Carman
9:45
9:50 243.1
Sphingosine-1-Phosphate: A Bridge from
Bench to Clinic. S. Spiegel. VCU Sch. of Med.
10:15
Tracking Diacylglycerol Pools in Budding
Yeast. S. Ganesan, M.L. Sosa Ponce, V. Zaremberg. Univ. of
Calgary, Canada. (872.3)
76
245. ASBMB ACCREDITATION WORKSHOP
Workshop
Mon. 12:15 pm—San Diego Convention Center, Room 14A
Learn the characteristics
undergraduate program.
of
an
ASBMB-accredited
MONDAYBIOCHEMISTRY
246. TELL YOUR SCIENCE AS A STORY
Special Session
(Sponsored by: ASBMB Public Outreach Committee)
247. MILDRED COHN AWARD IN BIOLOGICAL
CHEMISTRY AWARD LECTURE
Award Lecture
2:15
2:20 247.1
Molecular Visualization of the Eukaryotic
Transcription Initiation Process Using Cryo-EM. E. Nogales, R.
Louder, Y. He. Univ. of California, Berkeley, HHMI, Lawrence
Berkeley Natl. Lab. and Northwestern Univ.
248. EARL AND THRESSA STADTMAN SCHOLAR
AWARD LECTURE II
Award Lecture
2:50
2:55 248.1
Molecular Choreography of an Antibiotic
Assembly Line. S. Dutta, J.R. Whicher, D.A. Hansen, W.A.
Hale, J.A. Chemler, G.R. Congdon, A.R. Narayan, K.
Håkansson, D.H. Sherman, J.L. Smith, G. Skiniotis. Univ.
of Michigan.
249. SICKLE CELL DISEASE SEVERITY
Symposium
(Guest Society: Society for Experimental Biology and
Medicine)
Cochaired: S.R. Goodman and B.S. Pace
Clinical severity in sickle cell disease: definitions and
prognostication C. Quinn.
Rheological Abnormalities of Pediatric Hemoglobin SC
Patients V. Sheehan.
Genetic Basis of HbF Variability in Sickle Cell Anemia; A
Global Perspective M. Steinberg.
Is Hydroxyurea Efficacious in Both Severe and Non-Severe
Sickle Cell Disease?” Clinical severity in sickle cell disease:
definitions and prognostication W. Wang.
3:20 250.1
Symmetry and Computational Methods
in the Design of Self-Assembling Protein Materials.
T.O. Yeates. UCLA.
251. ENZYMOLOGY OF GLYCOSYL-TRANSFERASES
AND HYDROLASES
Symposium
Chaired: D. Vocadlo
4:00
4:05 251.1
Insights on Mammalian Glycosylation Enzymes
from High-Throughput Expression Studies. K. Moremen, L.
Meng, F. Forouhar, S. Wang, R. Kadirvelraj, H. Moniz, A.
Ramiah, Z. Gao, J. Seetharaman, S. Milaninia, G. Galay, M.
Stuart, J. Steel, J. Labaer, Z. Wood, L. Tong, D. Jarvis. Univ.
of Georgia, Columbia Univ., Univ. of Wyoming and Arizona
State Univ.
4:30
Regulation
of
Notch
Signaling
by
O-Glucosylation:
Notch-Modifying
XylosyltransferaseSubstrate Complexes Support an SNi-Like Retaining
Mechanism. R.S. Haltiwanger, H. Yu, M. Takeuchi, J.
LeBarron, J. Kantharia, E. London, H. Bakker, H. Li, H.
Takeuchi. Univ. of Georgia, Brookhaven Natl. Lab., NY, Stony
Brook Univ. and Hannover Med. Sch., Germany. (624.3)
4:45 251.2
Mechanistic and Structural Insights into a
Human Carbohydrate Degrading Enzyme. T. Gloster, M.
Alteen, V. Oehler, L. Yang, I. Wilson, D. Vocadlo. Univ. of
St. Andrews, U.K., Simon Fraser Univ., Canada and Univ. of
Natural Resources and Life Scis., Vienna, Austria.
5:10
Structure and Biosynthesis of Complex
N-Glycan Cores and Antennae in Nematodes. I.B.H. Wilson,
S. Yan, K. Paschinger. Univ. of Nat. Resources and Life Sci.,
Vienna. (843.4)
5:25
Defects in Protein O-Mannosylation Result in
Abnormal Muscle Contractions and Aberrant Neural Sensory
Feedback in Drosophila. V. Panin, R. Baker, N. Nakamura, D.
Lyalin. Texas A&M Univ. (846.1)
5:40 251.5
Piecing
Together
New
Insight
into
Glycosidases: Structure and Imaging. G. Davies. Univ. of York.
6:05
Discussion.
252.TRANSCRIPTIONAL
REGULATORY MECHANISMS
Symposium
Chaired: S. Lauberth
250. DELANO AWARD FOR COMPUTATIONAL
BIOSCIENCES LECTURE
Award Lecture
3:15
4:00
4:05 252.1
Impeding the Formation of Transcription
Initiation Complex. J-M. Egly. IGBMC, CNRS, INSERM, Univ.
of Strasbourg, Illkirch.
4:30
Mechanistic Study of ERCC6/CSB Enzymatic
Regulation, and Its Roles in Transcription Elongation, and
Chromatin Remodeling. D. Wang. UCSD. (803.8)
77
M
O
N
BIOCHEMISTRYMONDAY
4:45 252.2
Transcription and the Maintenance of Genome
Stability. J.Q. Svejstrup, L. Williamson, M. Saponaro,
S. Boeing, R. Mitter, G. Kelly. The Francis Crick Inst., South
Mimms and London, U.K.
5:10
Steroid Receptors Can Activate Unique
FoxA1 Binding Patterns through a Highly Dynamic Mechanism
Associated with a Fast DNA Residence Time. E.E. Swinstead,
T.B. Miranda, V. Paakinaho, S. Baek, M. Hawkins, T. Karpova,
D. Ball, D. Mazza, L.D. Lavis, T. Morisaki, L. Grøntved, D.M.
Presman, G.L. Hager. NCI, NIH, Univ. Vita Salute San Raffaele,
Milan, HHMI, Ashburn, VA and Univ. of So. Denmark. (585.5)
5:25
DNA Breaks and Damage Response Signaling
Are Coupled with RNA Polymerase II Promoter-Proximal Pause
Release and Required for Effective Transcriptional Elongation.
H. Bunch. Harvard Med. Sch., Beth Israel Deaconess Med.
Ctr. (589.1)
5:40 252.3
Elongin and the Elongin A Ubiquitin Ligase
Complex in Transcription and the Response to DNA Damage.
J.W. Conaway, J.C. Weems, B.D. Slaughter, J.R. Unruh, R.C.
Conaway. Stowers Inst. for Med. Res. and Univ. of Kansas
Med. Sch.
6:05
Discussion.
253. THE GREENING OF CHEMICAL BIOLOGY
Symposium
Mon. 4:00 pm—San Diego Convention Center, Room 6C
Chaired: M. Burkart
4:00
4:05 253.1
Chemical Biology and Endomembrane
Trafficking in Plants. G.R. Hicks, C. Zhang, W. Van de Ven, R.
Li, N. Raikhel. Univ. of California, Riverside.
4:30
Molecular Cloning and Expression of a Putative
Oleate Hydratase Isozyme from Nocardia cholesterolicum
NRRL 5767. J-K. Huang, H.B. Alhmadi, D.R. Vanderway, C.A.
Hoerner, L. Wen. Western Illinois Univ. (838.1)
4:45 253.2
Alkaloid Biosynthesis in Plants. S. O’Connor.
John Innes Ctr., Norwich, U.K.
5:10
Digging into Rice Diterpenoid Biosynthesis.
R. Peters. Iowa State Univ. (1146.1)
5:25
Structural Basis of Distinct Salicylic Acid
Glucosylation in Arabidopsis Thaliana by Two Homologous
Enzymes: Implications for Plant Stress Response. A.M. George
Thompson, C.V. Iancu, J. Dean, J-y. Choe. Rosalind Franklin
Univ. and DePaul Univ. (1142.3)
5:40 253.3
Molecular Controls in Plant Hormone Signaling.
J. Jez. Washington Univ. in St. Louis.
6:05
Discussion.
254. ASBMB YOUNG INVESTIGATOR AWARD LECTURE
Award Lecture
Mon. 4:00 pm—San Diego Convention Center, Room 6D
Presented in session, “Systems Biology of Cellular
Networks”. Refer to session 255 for additional details.
4:00
4:00 254.1
Adaptations to Mitochondrial Dysfunction via
Inter-Organelle Communication. C.M. Haynes. Mem. Sloan
Kettering Cancer Ctr.
78
255. SYSTEMS BIOLOGY OF
CELLULAR NETWORKS
Symposium
Chaired: A. Osterman
4:00
4:05
ASBMB Young Investigator Award Introduction
and Presentation.
4:10
Adaptations to Mitochondrial Dysfunction via
Inter-Organelle Communication. C.M. Haynes. Mem. Sloan
Kettering Cancer Ctr. (254.1)
4:35 255.3
Integrative Pathway Mapping. A. Sali. UCSF.
5:00
GRNmap and GRNsight: Open Source
Software for Dynamical Systems Modeling and Visualization
of Medium-Scale Gene Regulatory Networks. K.D. Dahlquist,
B.G. Fitzpatrick, J.D.N. Dionisio, N.A. Anguiano, J.S.
Carrillo, M.V. Hong, K.M. Horstmann, K.C. Jackson, K.G.
Johnson, T.A. Morris, T.A.M. Roque, M. Samdarshi, A.
Varshneya, N.E. Williams, K.W. Wyllie. Loyola Marymount
Univ., CA and Spelman Col., GA. (819.16)
5:15 255.2
The Cancer Cell Map Initiative. T. Ideker. UCSD.
5:40 255.1
Network Analytics: Evolutionary Compression,
Diffusion and the Action Equation for Mutations. O. Lichtarge.
Baylor Col. of Med.
6:05
Discussion.
256. SIGNALING IN TIME AND SPACE
Symposium
Mon. 4:00 pm—San Diego Convention Center, Room 6E
Chaired: D.J. Leahy
4:00
4:05 256.1
Endocytosis Separates EGF Receptors from
Endogenous Fluorescently Labeled HRas and Prevents
Receptor Signaling to MAP Kinases in Endosomes. A. Sorkin,
I. Pinilla-Macua. Univ. of Pittsburgh.
4:30
Super-Resolution Imaging of the HER Family
of Receptor Tyrosine Kinases. B. van Lengerich, E. Puchner,
B. Huang, N. Jura. UCSF and Univ. of Minnesota, Minneapolis.
(857.4)
4:45 256.2
New Mode of EGF Receptor Transactivation:
Regulated Ligand Delivery. R.J. Coffey, Z. Cao, B. Singh.
Vanderbilt Univ. Med. Ctr. and DVA Nashville, TN.
5:10
Three-Dimensional Quantification of the
Spatiotemporal Co-evolution of Vascular and Neuronal
Networks within Intact Eyes. J. Singh, D. Shepherd, G.
Seedorf, J. Brzezinski Univ. of Colorado Denver and Univ.
of Colorado Sch. of Med., Aurora. (857.1)
5:25
An Optogenetic Toolkit for Spatial and
Temporal Control of the cAMP Dependent Protein Kinase.
C.P. OBanion, R. Hughes, M. Priestman, D. Lawrence. Univ.
of North Carolina Chapel Hill. (857.2)
5:40 256.3
Spatial Correlation of Constitutive HER2
Activities with Cell Membrane Deformation. I. Chung. HHMI,
Ashburn, VA and Genentech, South San Francisco.
6:05
Discussion.
MONDAYBIOCHEMISTRY
257. NAFLD: GENETIC DETERMINANTS AND
EXTRAHEPATIC COMPLICATIONS
Symposium
Mon. 4:00 pm—San Diego Convention Center, Room 6F
Chaired: T. Sumter
5:10
Dietary Docosahexaenoic Acid Halts Progression of
Nonalcoholic Steatohepatitis, but Does Not Promote
Fibrosis Remission in Ldlr-/- mice. K.A. Lytle, C.
Wong, D. Jump. Oregon State Univ. (870.2)
4:45
Genetic and Environmental Risk Factors for Progression
of NASH R. Loomba, UCSD.
5:25
Regulation of AMPK and Hepatic Metabolism by Folic
Acid Supplementation in Non-alcoholic Fatty Liver
Disease. V. Sid, N. Wu, L. Sarna, Y. Shang, J. House,
Y.L. Siow, K. O. Univ. of Manitoba, St. Boniface
Hosp. Res. Ctr. and Agr. and Agri-Food Canada,
Winnipeg. (870.3)
4:30
Obesity Intensifies Hepatotoxicity by Asparaginase in
Mice Deleted for GCN2 but Not ATF4. I.A. Nikonorova,
E.T. Mirek, Y. Wang, J.L. Dixon, T.G. Anthony.
Rutgers, The State Univ. of New Jersey. (1126.1)
5:40 257.1
The Early Origins of NAFLD in Humans and
Non-human Primates. J.E. Friedman. Univ.of Colorado Denver.
4:05 257.2
Mitochondrial Protonophores for Treatment of
NAFLD/NASH and Type 2 Diabetes. G.I. Shulman. HHMI/Yale
Univ. Sch. of Med.
6:05Discussion.
4:00
258. MOLECULAR VISUALIZATION IS YOUR FRIEND
4:30
Combining Molecular Visualization with Bench
Methods in a Hypothesis-Driven Undergraduate Biochemistry
Lab Course. P.A. Craig, J.L. Mills, C. Daubner, M.J. Pikaart.
Sch. of Chem. & Mat. Sci., Rochester Inst. of Technol., Sch. of
Sci., Engin. and Technol., St. Mary’s Univ., San Antonio and
Hope Col., MI. (666.2)
4:45 258.2
Visualizing the Invisible: From Questions to
Conversations to Understanding. T. Herman. Milwaukee Sch.
of Engin.
5:10
Molecular Visualization in the Classroom:
Learning Goals and Competencies. D.R. Dries, P.A. Craig,
D.M. Dean, L. Listenberger, W.R.P. Novak, M.A. Franzen.
Juniata Col., PA, Rochester Inst. of Technol., Univ. of Saint
Joseph, CT, St. Olaf Col., MN, Wabash Col., IN and Milwaukee
Sch. of Engin. (666.1)
5:25
Reviving
“Byron’s
Bender”:
Hands-On
Molecular Visual and Tactile Learning at the Most Basic Level.
J.T. Hazzard, A. Issaian. Univ. of Arizona and Univ. of Colorado
Anschutz Med. Campus. (666.6)
5:40 258.3
Creating Stop-Motion Animations to Learn
Molecular Biology Dynamics. C. Peterson, P. Ngo. Suffolk Univ.
6:05
Discussion.
259. ORGANIZING A SUCCESSFUL ASBMB
STUDENT CHAPTER
Special Session
260. ASBMB GAME NIGHT
Special Event
Symposium
Join the ASBMB for an evening of networking and sciencethemed trivia with fellow graduate students and postdoc members
and biochem attendees.
Chaired: M.A. Carroll
261. ASBMB WIKI EDIT-A-THON
Workshop
4:00
4:05 258.1
Proteopedia: The 3D Wiki-Encyclopedia of
Protein and Nucleic Acid Structures. E. Hodis, J. Prilusky, J.
Sussman. Harvard Univ., MIT, Broad Inst., Cambridge, MA,
Dana-Farber Cancer Inst. and Weizmann Inst. of Sci., Israel.
(Sponsored by: Simons Foundation)
Come join ASBMB and the Simons Foundation at our
Wikipedia Edit-A-Thon, where we will tackle molecular biology
and biochemistry Wikipedia articles that are in dire need of
renovation and teach you the basics of Wikipedia editing.
Visit the Exhibits
April 3–April 5
Exhibit Hours
Sunday–Tuesday | 9:00 AM–4:00 PM
79
M
O
N
NUTRITIONMONDAY
Nutrition
FOOD FOR THE BRAIN: LEARNING HOW WHAT
WE EAT AFFECTS COGNITION AND MAY
PREVENT OR DELAY DEMENTIA
266. REGULATION OF HEALTH AND DISEASE BY
SULFUR AMINO ACID METABOLISM
Symposium
ASN Satellite
Mon. 8:00 am—San Diego Convention Center, Room
31ABC
(Organized and Sponsored by: the California
Walnut Commission)
Chaired: T.G. Anthony
Cochaired: J.W. Miller
Mon. 6:30 am—San Diego Convention Center, Room 33BC
Programs, please visit http://scientificsessions.nutrition.org
/satellitesessions/.
8:00
8:25
LOW CALORIE SWEETENER AND OBESITY:
SOLUTION OR PART OF THE PROBLEM
8:50
ASN Satellite
(Organized and Supported by: Tate and Lyle)
264. AGING AND CHRONIC DISEASE RIS
BUSINESS MEETING
RIS Forum
(Sponsored by: Aging and Chronic Disease RIS)
Mon. 7:00 am—San Diego Convention Center, Room 28DE
Chaired: C. Castaneda-Sceppa
265. RED AND PROCESSED MEATS AND HEALTH:
CONTROVERSIES FOR DIETARY GUIDANCE
Symposium
Ballroom 20D
Chaired: W.W. Campbell
Cochaired: F.B. Hu
8:00
Red and Processed Meats in the American Diet:
How Much Do We Really Eat? K. Belk. Colorado
State Univ.
8:20 Red Meat Intake and Dietary Patterns for Cardiometabolic Health. F. Hu. Harvard Univ.
8:55 Red Meat Intake and Dietary Patterns for
Cancer Prevention. M. McCullough. American
Cancer Society.
9:30 Dietary Guidance and the Future of Red Meats.
W. Campbell. Purdue Univ.
80
9:15
H2S in Health and Disease. R. Banerjee. Univ.
of Michigan.
Endogenous Hydrogen Sulfide Production is Essential
for Dietary Restriction Benefits. J. Mitchell. Harvard
T.H. Chan Sch. of Publ. Hlth.
Influence of Vitamin B6 Status on the In vivo Function
of the Transsulfuration Pathway in Sulfur Amino
Acid Metabolism and Hydrogen Sulfide Production.
J. Gregory. Univ. of Florida.
Cysteine and Obesity: Does Cysteine Link Amino Acid
and Lipid Metabolism? H. Refsum. Univ. of Oslo Inst.
of Basic Med. Sci.
LIPID AND FATTY ACID METABOLISM
AND TRANSPORT
Minisymposium
Chaired: M. Jacome-Sosa
Cochaired: J.M. Ellis
8:00 267.1
Supplementation with Dietary EPA/DHA
Influences Red Blood Cell Fatty Acid Desaturase Estimates
and Reflects Tissue Changes in Fatty Acids in Systemic
Organs. E.A. Davidson, C.A. Pickens, J. Fenton. Michigan
State Univ.
8:15 267.2
Lipid Emulsions, Rich in n-3 or n-9 Fatty Acids,
Reverse the Progression of Parenteral Nutrition-Induced
Hepatic Steatosis in Mice. K-H. Huang, P.B. Smith, A.D.
Patterson, A.C. Ross. Penn State
8:30 267.3
Effects of Hormone Therapy on the Association
between Erythrocyte Levels of n-3 Polyunsaturated Fatty Acids
and Depression in Postmenopausal Women. Y. Jin, Y. Park.
Hanyang Univ., South Korea.
8:45 267.4
A
22
bp
FADS2
Insertion-Deletion
Polymorphism Influences Arachidonic Acid Status. K.S.D.
Kothapalli, M.S. Gadgil, S.E. Carlson, K.O. O’Brien, K. Ye,
J.Y. Zhang, H.G. Park, K. Ojukwu, J. Zou, S.S. Hyon, K.S.
Joshi, A. Keinan, J.T. Brenna. Cornell Univ., Univ. of Pune,
India and Univ. of Kansas.
9:00 267.5
Dietary α-Linolenic Acid-Rich Flax Oil Elevates
Renal and Hepatic Docsosahexaenoic Acid-Derived Bioactive
Lipids. J.G. Devassy, T. Yamaguchi, N. Ibrahim, M. Gabbs, T.
Winter, A. Ravandi, H.M. Aukema. Univ. of Manitoba and St.
Boniface Hosp. Res. Ctr., Winnipeg.
MONDAYNUTRITION
9:15 267.6
Programming Effects of Infant Diet on
Cholesterol/Bile Acid Synthesis and Absorption in Piglets.
K.E. Mercer, M.E. Diaz-Rubio, S. Bhattacharyya, N. Sharma,
L. Yeruva. Univ. of Arkansas for Med. Sci. and Arkansas
Children’s Nutr. Ctr.
9:30 267.7
Development of Nonalcoholic Fatty Liver in
Superoxide Dismutase-1 Knockout Mice Was Associated with
Altered Expression of Hepatic Fibroblast Growth Factor-21.
D. Chakraborty, X.G. Lei. Cornell Univ.
9:45 267.8
Adipocyte-Specific Ablation of Long-Chain
Acyl-CoA Synthetase-4 in Mice Protects against DietInduced Obesity-Associated Decreases in White Adipocyte
Oxygen Consumption and Whole Body Energy Expenditure.
E.A. Killion, D. Kong, A.S. Greenberg. USDA at Tufts Univ.
and Tufts Univ. Sackler Sch. of Grad. Biomed. Sci.
268. INTERNATIONAL FORUM—TAIWAN
Moved to Sunday following session 132.
269. DBC: ANTI-INFLAMMATORY DIETARY
BIOACTIVE COMPONENTS
Minisymposium
Chaired: N. Ford
8:00 269.1
Anti-inflammatory and Anti-cancer Effects of
the Colonic Metabolites of Polymethoxyflavone. M. Wang, X.
Wu, M. Song, H. Xiao. Univ. of Massachusetts Amherst.
8:15 269.2
Green Tea Extract Lowers NFκB-Mediated
Inflammation during Nonalcoholic Steatohepatitis in Mice Fed
a High-Fat Diet Consistent with Reduced Toll-Like Receptor-4
Signaling. J. Li, C. Chitchumroonchokchai, J.B. Kim, M.V.
Moller, R.S. Bruno. The Ohio State Univ.
8:30 269.3
Dietary
Sphingomyelin
Attenuates
Inflammation and Metabolic Dysfunction in Diet-Induced
Obese Mice. G.H. Norris, C.M. Porter, C. Jiang, C. Blesso.
Univ. of Connecticut.
8:45 269.4
Tannase-Treated Grape Pomace Attenuates
IL-1β-Induced Inflammation in Caco-2 Cells. I. Martin, G.
Macedo, J. Blumberg, C-Y.O. Chen. USDA at Tufts Univ. and
State Univ. of Campinas (UNICAMP), Brazil
9:00 269.5
Gamma Tocotrienol Suppresses NLRP3
Inflammasome by Dual Mechanism of A20-Mediated Priming
Inhibition and AMPK/Autophagy Axis Activation. Y. Kim, S.
Chung. Univ. of Nebraska-Lincoln.
9:15 269.6
Docosahexaenoic Acid Inhibits CeruleinInduced Cytokine Expression by Activating Peroxisome
Proliferator-Activated Receptor γ in Pancreatic Acinar Cells.
E.A. Song, J.W. Lim, H. Kim. Col. of Human Ecol., Yonsei
Univ., South Korea.
9:30 269.7
Periodontal Symptoms and Inflammation
following Non-surgical Treatment and 4 Months of Fish Oil
Supplementation. A. Coates, T. Fitzsimmons, B. Chee, B.
Park, K. Kapellas, P. Howe, R. Lee, S. Ivanovski. Univ. of
South Australia, Univ. of Adelaide, Univ. of Newcastle and Sch.
of Dent. and Oral Hlth., Griffith Univ., Australia.
9:45 269.8
Anti-inflammatory Properties of Tangeretin,
5-Demethyltangeretin and Their Primary Metabolites.
S. Guo, X. Wu, J. Zheng, P. Dong, P. Qiu, H. Xiao. Univ. of
Massachusetts Amherst and Univ. of Jinan, China.
270. OBESITY: CHILDHOOD
OBESITY MANAGEMENT
Minisymposium
Chaired: M. Cope
8:00 270.1
Does Milk Portion Size or Energy Density
Affect Preschool Children’s Lunch Intake? S.M.R. Kling, L.S.
Roe, B.J. Rolls. Penn State
8:15 270.2
Effects of a Higher versus Lower Protein Diet
on Weight Loss in Teenagers: Results from a Randomized
Controlled Trial. J.W. Apolzan, D.S. Hsia, C.K. Martin.
Pennington Biomed., Baton Rouge.
8:30 270.3
Orbitofrontal Cortex Response to Food Portion
Size Is Linked with Obesogenic Appetitive Profile in Children.
L.K. English, S.N. Fearnbach, M. Lasschuijt, S.J. Wilson,
M. Tanofsky-Kraff, B.J. Rolls, K.L. Keller. Penn State,
Wageningen Univ., Netherlands and Uniformed Svcs. Univ. of
Hlth. Sci., Bethesda.
8:45 270.4
A Randomized, Controlled, Parallel Study to
Assess the Effects of Soy Protein on Body Composition and
General Health Parameters in Healthy Children. M. Braun, C.
Cook, R. Mukherjea, D. Liska. DuPont Nutr. & Hlth., St. Louis
and Mérieux NutriSci., Addison, IL.
9:00 270.5
Network Social Support for Healthy and
Obesogenic Behavior Influences Children’s Dietary Intake
and Weight Change during Family-Based Behavioral Obesity
Treatment. K.N. Balantekin, J.F. Hayes, R.P. Kolko, R.I. Stein,
B.E. Saelens, R.R. Welch, M.G. Perri, K.B. Schechtman, L.H.
Epstein, D.E. Wilfley. Washington Univ. Sch. of Med., Univ. of
Pittsburgh, Seattle Children’s Hosp., Univ. of Florida and Univ.
at Buffalo.
9:15 270.6
Beverage Consumption among Advantest
Adolescents in the Teen FAD Study. M. Nezami, J. Sabate, L.
Beeson, G. Segovia-Siapco. Loma Linda Univ.
9:30 270.7
A Father’s Response to Having a Child Who Is
Overweight/Obese. F.L. Battisti, H.E. Battisti. SUNY Broome,
Binghamton and Marywood Univ., PA.
9:45 270.8
Initial Results from a Real-World Pediatric
Specialty Weight Management Clinic in a Safety-Net Hospital.
C.M. Lenders, K.D. Plourde, A.J. Manders, K. Ireland. Boston
Univ. Sch. of Med., Boston Med. Ctr. and Boston Univ. Sch. of
Publ. Hlth.
81
M
O
N
NUTRITIONMONDAY
METABOLIC PHENOTYPING, METABOLOMICS
AND BIOMARKERS
272. VITMIN: B VITAMINS AND ONECARBON METABOLISM
Minisymposium
Minisymposium
Chaired: M.R. Panasevich
8:00 271.1
Determination of CYP1A2 Activity in the U.S.
Population by Use of Caffeine Metabolite Ratios in Spot Urine
Samples: NHANES 2009–2010. M.E. Rybak, M.R. Sternberg,
C-I. Pao, C.M. Pfeiffer. Ctr. for Dis. Control and Prevent.
8:15 271.2
Fasting Plasma Metabolomics Reveal Specific
Dietary Patterns in Sow-Fed Neonatal Piglets Compared to
Soy- or Dairy-Based Formula Feeding. B.D. Piccolo, M.E.
Diaz-Rubio, K.E. Mercer, L. Yeruva. Arkansas Children’s Nutr.
Ctr. and Univ. of Arkansas for Med. Sci.
8:30 271.3
Impact of Vitamin D Status and High-Dose
Vitamin D3 Administration on the Plasma Metabolome in
Critically Ill Adults. K. Perry-Walker, D.I. Walker, J.A. Alvarez,
J.E. Han, J.L. Jones, L. Hao, S. Li, K. Uppal, V.T. Tran, L.
Brown, V. Tangpricha, G.S. Martin, D.P. Jones, T.R. Ziegler.
Med. Col. of Georgia and Emory Univ.
8:45 271.4
Effects of HMB and Beta-Alanine Cosupplementation and Running Wheel Activity on Skeletal
Muscle Morphometry and Metabolomics in Aged Rats.
S.M. Garvey, J. Desai. Abbott Nutr., Columbus, OH and Univ.
of Illinois at Urbana-Champaign.
9:00 271.5
Ablation of BCO2 Leads to Increased
Susceptibility to High Fat Diet-Induced Metabolic Disorders in
Mice. L. Wu, X. Guo, A. Davis, T.P. Soh, S. Clarke, E. Lucas,
B. Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma State
Univ., Kansas State Univ. and Univ. of Missouri-Kansas City.
9:15 271.6
Altered Fatty Acid Metabolism Remodels the
Hypothalamic Metabolome to Stimulate Feeding Behavior in
BCO2 Knockout Mice. X. Guo, L. Wu, T. Soh, W. Chowanadisai,
S. Clarke, E. Lucas, B. Smith, W. Wang, D. Medeiros, D.
Lin. Oklahoma State Univ., Kansas State Univ. and Univ. of
Missouri-Kansas City.
9:30 271.7
Obesity Is Associated with Distinct Changes in
the Human Plasma Phospholipidome. C.A. Pickens, D. Jones,
J.I. Fenton. Michigan State Univ.
9:45 271.8
Use of Plasma Metabolomics at Diagnosis
to Identify Metabolic Pathways Associated with Pulmonary
Tuberculosis Clearance: A Pilot Study. E. Chong, J.K. Frediani,
J.A. Alvarez, V. Tangpricha, H.M. Blumberg, D.P. Jones, T.
Yu, T.R. Ziegler. Emory Univ.
8:00 272.1
Maternal Choline Supplementation Modulates
Maternal and Fetal Choline Metabolism and Downregulates
Inflammatory Gene Expression in a Mouse Model of Placental
Insufficiency. J.H. King, S.T. Kwan, J. Yan, X. Jiang, V.G.
Fomin, M.S. Roberson, M.A. Caudill. Cornell Univ. and
Brooklyn Col.
8:15 272.2
Increased Circulating Trimethylamine N-Oxide,
a Gut-Flora-Dependent Metabolite of Choline and Betaine
in Nonalcoholic Fatty Liver Disease Is Associated with High
Serum Bile Acids. H-l. Zhu, X-y. Tan, Y. Liu, X-l. Chen. Sun
Yat-sen Univ., China.
8:30 272.3
Vitamin B12 and Placental Expression of
Transcobalamin in Pregnant Adolescents. A.J. Layden,
K.O. O’Brien, E.K. Pressman, T.R. Kent, J.L. Finkelstein.
Cornell Univ., Univ. of Rochester Med. Ctr. and St. John’s Res.
Inst., Bangalore.
8:45 272.4
Dietary Glycine Alters One-Carbon Metabolic
Kinetics In Vivo. Y-H. Huang, E-P.I. Chiang. Natl. Chung Hsing
Univ., Taiwan.
9:00 272.5
Maternal Choline Supplementation Influences
Placental Glucose Uptake and Metabolism in a Manner
Dependent on Fetal Sex. S.T. Kwan, J.H. King, J. Yan, X.
Jiang, J.S. Hutzler, M.S. Roberson, M.A. Caudill. Cornell
Univ. and Brooklyn Col.
9:15 272.6
Cholesterol Homeostasis Alters One Carbon
Metabolism In Vitro and In Vivo. H-A.S. Ko, Y-T.I. Wu, N-L.S.
Sou, E-P. Chiang. Natl. Chung Hsing Univ., Taiwan.
9:30 272.7
One-Carbon Metabolic Kinetics in Human
Disease Models. E.I. Chiang, Y-C. Wang, M-T. Wu, Y-J. Lin,
H-A. Ko, Y-H. Huang, N-L. Sou, Y-M. Chen, F-Y. Tang. Natl.
Chung Hsing Univ., Kao-Hsiung Med. Univ. and China Med.
Univ., Taiwan.
9:45 272.8
Vitamin B12 Deficiency Defined Using Total
Cobalamin, Holo-transcobalamin II, and an Algorithm of Both
Total Cobalamin and Holo-transcobalamin II in Vegetarians,
Vegans, and Omnivores. T. Arnold, J. Knurick, C. Johnston.
Arizona State Univ. and Univ. of Nevada Las Vegas.
82
MONDAYNUTRITION
FOOD SECURITY AND ITS CONNECTIONS TO
NUTRITION AND HEALTH SECTION II
274. GLOBAL NUTRITION: NUTRITIONSENSITIVE PROGRAMS
Minisymposium
Minisymposium
Nutrition RIS)
Chaired: M. Ruel
Chaired: J. Nelson-Peterman
8:00 273.1
Ethnic Differences in Cumulative Exposure to
Food Insecurity and Risk of Childhood Asthma. L.D. Mangini,
Y. Dong, M.D. Hayward, M.R. Forman. The Univ. of Texas
at Austin.
8:15 273.2
Perceived Benefits of Livestock Ownership
among Female Smallholder Farmers of Mixed HIV Status in
Nyanza Province, Kenya. A. Maranga, S.E. Dumas`, P.E.
Mbullo, P. Wekesa, M. Onono, S.L. Young. Cornell Univ. and
Kenya Med. Res. Inst. (KEMRI), Nairobi.
8:30 273.3
Food Insecurity Is Associated with Faster
Cognitive Decline: Boston Puerto Rican Health Study. J. Wong,
T. Scott, P. Wilde, Y. Li, K.L. Tucker, X. Gao. Brigham and
Women’s Hosp., Tufts Med. Ctr., Friedman Sch. of Nutr.
Sci. and Policy, Tufts Univ., Univ. of South Florida, Univ. of
Massachusetts Lowell and Penn State.
8:45 273.4
Food Insecurity Is Associated with Depression
and Stress among a Cohort of Pregnant Kenyan Women of
Mixed HIV Status. I. Tsai, N.R. Krumdieck, S. Collins, E.M.
Widen, P. Wekesa, M. Onono, S.L. Young. Cornell Univ., Weill
Cornell Med., Columbia Univ. Med. Ctr. and Kenya Med. Res.
Inst., Kisumu.
9:00 273.5
Food Insecurity Status and Mortality in Ontario,
Canada. C. Gundersen, V. Tarasuk, J. Cheng, C. de Oliveira,
P. Kurdyak, N. Dachner. Univ. of Illinois, Urbana, Univ. of
Toronto and Ctr. for Addiction and Ment.l Hlth., Toronto.
9:15 273.6
Are Monthly Food Insecurity Assessments
Necessary? A Longitudinal Analysis in Rural Zambia. M. Na,
B.L. Caswell, S.A. Talegawkar, A. Palmer. Johns Hopkins
Bloomberg Sch. of Publ. Hlth. and George Washington Univ.
9:30 273.7
Food Insecurity and Young Child BMI Status in
the U.S. Affiliated Pacific Region: Findings from the Children’s
Healthy Living Program. F. Li, R. Novotny, L.R. Wilkens, M.K.
Fialkowski, R.R.T. Guerrero, P. Coleman, A. Bersamin,
T. Fleming, J. Deenik. Univ. of Hawaii, Univ. of Guam, No.
Marianas Col., Univ. of Alaska Fairbanks and American Samoa
Community Col., Pago Pago.
9:45 273.8
Household Food Insecurity Access Scale and
Household Food Insecurity Access Prevalence as Predictor
of Stunted Child and Overweight/Obese Mother in Urban
Indonesia. T. Mahmudiono, D.R. Andrias, T.S. Nindya, H.
Megatsari, R. Rosenkranz. Kansas State Univ. and Univ.
Airlangga, Indonesia
Cochaired: S. Sinharoy
8:00 274.1
Access and Adoption of Nutrition Specific
and Nutrition Sensitive Messages in Ethiopia: A Qualitative
Gendered Comparison. M. Min-Barron. Friedman Sch. of
Nutr. Sci. and Policy, Boston.
8:15 274.2
An Integrated Agriculture and Nutrition
Program in Burkina Faso Has Positive Intra-household
Spillover Effects on Maternal and Child Nutritional Status, but
No Sustained Long-Term Improvements in Household Welfare.
L. Bliznashka, D.K. Olney, M.T. Ruel, R. Rawat, E. Becquey,
O. Birba. IFPRI, Washington, DC.
8:30 274.3
Nutrition Sensitivity in Ethiopia’s Productive
Safety Net Programme: Tracing the Movement of an Idea
in Ethiopia’s Development Landscape. A.M. Warren, E.A.
Frongillo, S. Gillespie. Univ. of South Carolina, IFPRI,
Washington, DC and Transform Nutr., Brighton, U.K.
8:45 274.4
The Effects of a Nutrition-Sensitive Agricultural
Intervention on Social Support, Food Security and Maternal
Self-Efficacy in Complementary Feeding. D. Toure, R. Rawat,
R.J. Stoltzfus, D. Harvey, M. Mwanamwenge, D.L. Pelletier.
Cornell Univ., IFPRI, Dakar and Concern, Zambia.
9:00 274.5
An Integrated Nutrition-Sensitive Health and
Agriculture Intervention to Increase Egg Consumption among
Infants and Young Children in Upper Manya Krobo, Ghana.
A. Atuobi-Yeboah, G.S. Marquis, E. Colecraft, R. Kanlisi, R.
Aryeetey, M. Klevor. Sch. of Publ. Hlth., Univ. of Ghana, McGill
Univ., St. Anne de Bellevue and Heifer Ghana.
9:15 274.6
Household Food Insecurity and Hunger in
Selected Ethiopian Agricultural Communities: Examination of
Supply and Demand Factors. G.A. Zello, G. Ersino, C.J. Henry,
N. Regassa. Col. of Pharm. & Nutr., Univ. of Saskatchewan
and Hawassa Univ., Ethiopia.
9:30 274.7
Global Dietary Data Availability: Results of a
Systematic Worldwide Search for Data on Dietary Intakes of
55 Foods and Nutrients. G. Singh, M. Shulkin, K. Morrish,
A. Tahira, D. Marsden, D. Mozaffarian. Friedman Sch. of Nutr.
Sci. & Policy, Tufts Univ.
9:45 274.8
Large-Scale Television Campaign Associated
with Higher Prevalence of Exclusive Breastfeeding in
Vietnam. T.T. Nguyen, S. Alayón, P.H. Nguyen, A. Jimerson,
N. Hajeebhoy, J. Baker, E.A. Frongillo. FHI 360, Hanoi, FHI
360, Save the Children and IFPRI, Washington, DC and Univ.
of South Carolina.
83
M
O
N
NUTRITIONMONDAY
MAMMARY GLAND FUNCTION AND EFFECTS
OF MILK COMPONENTS ON INFANT HEALTH
Minisymposium
Minisymposium
Science RIS)
Chaired: S. Kelleher
Chaired: A.R. Mobley
Cochaired: S. Lee
Cochaired: A. Bersamin
8:00 275.1
ZnT2-Mediated Zn Transport Is Required
for Vesicle Acidification and Milk Secretion during Lactation.
S. Lee, O.C. Rivera, S.L. Kelleher. Penn State Hershey Col.
of Med.
8:15 275.2
The Effect of Genetic Variation on the Human
Milk Proteome. D.G. Lemay, K.L. Beck, E. Kwok, B.S.
Phinney, I. Korf. Univ. of California, Davis.
8:30 275.3
Effects of Metformin Exposure during Lactation
on Mouse Offspring Metabolic Health and Maternal Lactation
Characteristics. B. Gregg, J. Brill, N. Botezatu, M.R. Smith.
Univ. of Michigan.
8:45 275.4
Mammary Gland Structure and Functional
Changes in Mouse Model of Chronic Gestational Alcohol
Exposure. R.M. Amos-Kroohs, A.A. Cheng, R.D. Clugston,
T-N. Huang, C-L. Yen, W.S. Blaner, S.M. Smith. Univ. of
Wisconsin-Madison and Columbia Univ.
9:00 275.5
Acidic Human Milk Oligosaccharides Vary
across Populations and over Lactation. D.S. Newburg, C.
Chen, A. Cline, A.L. Morrow. Boston Col. and Cincinnati
Childrens Hosp. Med. Ctr.
9:15 275.6
Role of Human Milk Oligosaccharides in Fetoplacental Endothelial Function in Gestational Diabetes Mellitus.
E. Jantscher-Krenn, J. Aigner, U. Lam, M. van Poppel, L.
Bode, G. Desoye. Med. Univ. of Graz, Univ. of Graz, Austria
and UCSD.
9:30 275.7
Term Infant Formula Supplemented with
Human Milk Oligosaccharides (2’Fucosyllactose and Lacto-Nneotetraose) Shifts Stool Microbiota and Metabolic Signatures
Closer to That of Breastfed Infants. P. Steenhout, P. Sperisen,
F-P. Martin, N. Sprenger, S. Wernimont, S. Pecquet, B.
Berger. Nestlé Hlth. Sci., Vevey, Nestlé Inst. of Hlth. Sci.,
Lausanne, Nestlé Res. Ctr., Lausanne, and Nestlé Nutr., King
of Prussia and Vevey, Switzerland.
9:45 275.8
Unlike Adipokines, Insulin Concentrations in
Human Milk Surpass Those in Maternal Circulation, Are Higher
among Overweight Women, and Are Associated with Maternal
Insulin Resistance. B.E. Young, C. Westcott, C. ChartierLogan, T. Hernandez, L. Barbour, J. Friedman, N.F. Krebs.
Univ. of Colorado Sch. of Med.
84
276. NUTRITION EDUCATION: CHILDHOOD
OBESITY PREVENTION
8:00 276.1
Cardiac Kids Club Improves Nutrition
Knowledge, Dietary Intake, and Fitness among 4th & 5th
Graders. M. Beck, M. Spence, K. Clay, C. Perry-Burst, S.
Colby, K. Kavanagh. Univ. of Tennessee, Knoxville and Knox
County Schs.
8:15 276.2
Association of Fathers’ Income and Education
Level with Childhood Obesity Risk Factors in Preschool Age
Children. R.L. Vollmer, A. Kari, J.S. Foster, A.R. Mobley.
Illinois State Univ. and Univ. of Connecticut.
8:30 276.3
Assessment of Circannual Variation in Relative
Weight among Children in Wisconsin Using Electronic Health
Records. S. Bhutani, D. Schoeller, J. Kloke, L. Hanrahan.
Univ. of Wisconsin-Madison
8:45 276.4
Parental Intention to Engage in Healthier
Beverage Practices: Effects of Gain-versus Loss-Framed
Messages. A. Zahid, M. Reicks. Univ. of Minnesota, St. Paul.
9:00 276.5
Impact of the Shaping Healthy Choices Program
on Students’ Lunchtime Fruit and Vegetable Consumption:
A Randomized Controlled Trial of a Multicomponent SchoolBased Nutrition Intervention. J.C. Taylor, R.E. Scherr, J.D.
Linnell, G. Feenstra, M. Dharmar, S. Zidenberg-Cherr.
Univ. of California, Davis and Univ. of California Davis Hlth.
Syst., Sacramento.
9:15 276.6
Caregivers’ Estimations of 4-7-y-Old Children’s
Food Neophobia and Eating Temperament and Observations
of Children’s Food Refusals. S.L. Johnson, W.J. Gavin, P.
Davies, B. Taylor, R.E. Boles, L.L. Bellows. Univ. of Colorado
Anschutz Med. Campus and Colorado State Univ.
9:30 276.7
Television Food Advertisement Exposure and
FTO Genotype in Relation to Excess Consumption in Children.
D. Gilbert-Diamond, J. Emond, R.K. Lansigan, K. Rapuano,
W. Kelley, T. Heatherton, J. Sargent. Geisel Sch. of Med. at
Dartmouth and Dartmouth Col.
9:45 276.8
Using a Humanoid Robot along with a
Registered Dietitian in an After-School Program to Promote
Healthy Eating Habits and Physical Activity in School-Aged
Children. N. Mikati, M. Eltoukhy, F. Huffman. Florida Intl. Univ.
and Univ. of Miami.
MONDAYNUTRITION
277. THE PRESIDENTIAL SYMPOSIUM: SYSTEMS
APPROACHES IN NUTRITION
Special Session
Ballroom 20D
281. DIETARY BIOACTIVE COMPONENTS RIS
BUSINESS MEETING AND HOT TOPIC:
PROCESSING EFFECTS ON BIOACTIVE
FOOD COMPONENTS AND THE IMPACT ON
TRANSLATING LABORATORY STUDIES TO
HUMAN HEALTH OUTCOMES
Chaired: P.J. Stover
RIS Forum
Mon. 12:45 pm—San Diego Convention Center, Room 31ABC
10:30
Achieving Precision Nutrition in Public Health, Dietary
Guidance and Food Systems: Mathematical and
Computational Approaches from Complexity Systems.
R. Hammond. Brookings Inst.
10:50 Small Data and mHealth. D. Estrin. Cornell Tech.
11:10 100K Wellness Project: The First-ever Broadly
Integrative Approach to Scientific Wellness. N. Price.
Inst. for Syst. Biol.
11:30 Metabolomics Approaches to Classifying Patient
Populations and Identifying Responders and Nonresponders to Nutrition Interventions. K. Hiller.
Luxembourg Ctr. for Syst. Biomed.
278. E.V. MCCOLLUM INTERNATIONAL
LECTURESHIP IN NUTRITION
Chaired: J.D. Lambert
282. DIET AND CANCER RIS BUSINESS MEETING
AND HOT TOPIC: RED MEAT, PROCESSED
MEAT, AND CANCER: WHAT’S NEXT?
RIS Forum
Mon. 1:00 pm—San Diego Convention Center, Room 32AB
Chaired: E. Cho
283. MATERNAL, PERINATAL AND PEDIATRIC RIS/
ISRHML BUSINESS MEETING AND LUNCHEON
RIS Forum
Award Lecture
Ballroom 20D
(Cosponsored by: The International Society for Research
in Human Milk and Lactation (ISRHML))
1:45 R.J. Stoltzfus. Cornell Univ
279. NUTRITION TRANSLATION RIS BUSINESS
MEETING, KEYNOTE PRESENTATION AND
NETWORKING EVENT
RIS Forum
Mon. 12:45 pm—San Diego Convention Center, Room 28DE
Chaired: S. Kelleher
284. HEALTH RECOMMENDATIONS FOR DIETARY
SUGARS: WHY CAN’T WE ALL AGREE?
(Sponsored by: Nutrition Translation RIS)
Symposium
Mon. 1:00 pm—San Diego Convention Center, Room 33BC
Ballroom 20D
Chaired: M. Braun
Chaired: D.M. Bier
280. MEDICAL NUTRITION COUNCIL BUSINESS
MEETING
RIS Forum
Cochaired: D.M. Klurfeld
3:00
(Sponsored by: Medical Nutrition Council)
Chaired: C.W. Bales
3:18
3:36
3:54
4:12
4:30
Science Basis Used to Develop Recommendations
Regarding Dietary Sugars: Challenges of Using Available
Sugars Data for Recommendations. J. Sievenpiper.
Univ. of Toronto.
Metrics Used by the 2015 DGAC to Develop Dietary
Recommendations Regarding Sugars in the Diet.
M. Neuhouser. Fred Hutchinson Cancer Res. Ctr.
Metrics Used to Develop Dietary Recommendations
Regarding Sugars in Diet. T. Nicklas. Baylor Univ.
Strength of Dental Caries Evidence Used to Formulate
Recommendations for Dietary Sugars Intake. D. Zero.
Indiana Univ. Sch. of Dent.
DevelopmentofScientificallyValidHealthRecommendations
Regarding Dietary Sugars in the Current Regulatory
Environment. B. Schneeman. USAID.
Panel Discussion.
85
M
O
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NUTRITIONMONDAY
285. POSTPRANDIAL INFLAMMATION: ENDOTOXIN
OR FREE FATTY ACIDS?
Symposium
Mon. 3:00 pm—San Diego Convention Center, Room
31ABC
Chaired: D.H. Hwang
Cochaired: K.L. Fritsche
3:00
Postprandial Inflammation: Overview. P. Calder. Univ.
of Southampton.
3:25 High Fat Diet-induced Postprandial Endotoxemia.
M-C. Michalski. INRA.
3:50 Plasma Free Fatty Acids: Major Determinant for
Postprandial Inflammation. D. Hwang. Western
Human Nutri. Res. Ctr. (ARS/USDA), UC-Davis.
4:15 Methodological Challenges Associated with and
Possible Solutions to Measuring Endotoxin in Plasma/
Sera Samples. K. Fritsche. Univ. of Missouri.
286. MAKING YOUR SCIENTIFIC DISCOVERIES
KNOWN: BEST PRACTICES FOR EFFECTIVE
AND CREDIBLE COMMUNICATION
Symposium
Mon. 3:00 pm—San Diego Convention Center, Room 33BC
3:15 287.2
Gene Expression of Vitamin D Regulatory
Enzymes in Renal Tissue of Growing Pigs Is Modulated by
Maternal Dietary Vitamin D Concentrations. L. Amundson, T.
Crenshaw. Univ. of Wisconsin-Madison.
3:30 287.3
Consequences of Maternal Iron-Deficiency:
Fetal Anemia, and Hypoxia in Select Tissues of the Conceptus.
A. Woodman, Y. Mansour, S. Bourque. Univ. of Alberta.
3:45 287.4
Dysfunction of Insulin-Like Growth Factor
Signaling in Skeletal Muscles of Low Birth Weight Neonatal
Pigs. Y. Chen, H. Zhu, S.R. McCauley, K.R. Oliver, K.A.
Tinnesz, S.W. El-Kadi. VPI and State Univ.
4:00 287.5
Metabolic Phenotype and Increased Adiposity
in a Mouse Model of Chronic Gestational Alcohol Exposure.
R.M. Amos-Kroohs, D.W. Nelson, C-L.E. Yen, S.M. Smith.
Univ. of Wisconsin-Madison.
4:15 287.6
Postnatal Changes in Low Birth Weight Piglets
Fed a High-Energy Diet. S.R. McCauley, Y. Chen, K.R. Oliver,
R.P. Rhoads, S. El-Kadi. VPI and State Univ.
4:30 287.7
Effects of DHA and Choline Supplementation
on Developmental Outcomes of the Typically Developing
and Fetal Alcohol Exposed Rat Pup. L.G. Canipe III, T.W.
Jackson, C.L. Cheatham. Univ. of North Carolina at Chapel
Hill, Kannapolis.
4:45 287.8
Gestational Exposure to Maternal Obesity
Influences β3-Adrenergic Agonist-Induced Beiging of White
Adipose Tissue in Offspring. K. Shankar, P. Kang, Y. Zhong,
K.M. Thakali, U.D. Wankhade. Arkansas Children’s Nutr. Ctr.,
Little Rock.
288. INTERNATIONAL FORUM – CHINA
Chaired: M. Braun
International Forum
Cochaired: M.N. Lesser
(Organized and Sponsored by: the Chinese Nutrition
Society and North American Chinese Society
for Nutrition)
Education
3:00
3:30
4:40
Time in the Public Eye: Maintaining Credibility While
Using Your Voice. K. Sollid, A. Brown, C. Weaver,
J. Hill, A. Beaudreault. IFIC, Univ. Alabama at
Birmingham, Purdue Univ., Univ. of Colorado
Anschutz Med. Campus, Univ. of California-Davis.
Beyond the Bench: Communicating Science through
Stories. J. Storlie. Storlietelling LLC.
Using Your Voice Now: Next Steps and Future Directions.
A.C. Ross. Pennsylvania State Univ.
287. EXPERIMENTAL ANIMAL NUTRITION:
ANIMAL MODELS OF FETAL
NUTRITION, PROGRAMMING AND
NEONATAL DEVELOPMENT
Minisymposium
Chaired: R.N. Dilger
Cochaired: S. Jacobi
3:00 287.1
Maternal
High-Fructose
in
Pregnancy
Adversely Affects Morphological Aspects of the Placenta.
A. Song, S. Astbury, A. Hoedl, N. Coursen, W. Dixon,
D. Hemmings, R. Bell. Univ. of Alberta.
86
Mon. 3:30 pm—San Diego Convention Center, Room 32AB
Chaired: C. Wu
Cochaired: C. Guo
3:30
CNS – NACSN Collaboration: Training Programs.
Y. Wang. Univ. at Buffalo, SUNY
3:40
CNS – NACSN Collaboration: Research Enhancement.
H. Mo. Georgia State Univ.
3:50 Introduction of the First International Nutrition
Congresses. C. Guo. Chinese Nutr. Society
4:00 Introduction of Chinese Dietary Reference Intakes.
Y. Cheng. Chinese Nutr. Society
4:15 Nutrition and Global Health. TBD. North American
Chinese Society for Nutr.
4:30 S-Adenosyl-homocyeteine as An Intermediate Metabolite
of Methinion and Atherosclerotic Cardiovascular
Diseases. W. Ling. Chinese Nutr. Society
4:45
Optimal Pregnant Weight Gain and Dietary Status of
Women in A Urban Population from Eastern Jiangsu
of China. Z. Wang. Chinese Nutr. Society, Nanjing
Med. Univ.
MONDAYNUTRITION
289. DBC: HUMAN INTERVENTION STUDIES WITH
DIETARY BIOACTIVE COMPONENTS
Minisymposium
290. NUTRITIONAL EPIDEMIOLOGY:
EPIDEMIOLOGICAL RESEARCH ADDRESSING
DIET AND HEALTH OUTCOMES
Minisymposium
Chaired: A.P. Neilson
Cochaired: A. BASU
3:00 289.1
Green Tea Extract and Catechol-OMethyltransferase (COMT) Genotype Modify Fasting Serum
Insulin and Plasma Adiponectin Concentrations in a Randomized
Controlled Trial of Overweight and Obese Postmenopausal
Women. A. Dostal, H. Samavat, L. Espejo, A. Arikawa, N.R.
Stendell-Hollis, M.S. Kurzer. Univ. of Minnesota, St. Paul,
Univ. of North Florida and Central Washington Univ.
3:15 289.2
Systematic Review of Anthocyanins and
Markers of Cardiovascular Disease. T.C. Wallace, M. Slavin,
C.L. Frankenfeld. George Mason Univ.
3:30 289.3
Green Tea Extract Supplementation Modifies
Circulating Lipids In Postmenopausal Women: A Randomized,
Placebo-Controlled Clinical Trial. H. Samavat, A. Rose,
A. Dostal, R. Wang, A. Wu, J-M. Yuan, M. Kurzer. Univ. of
Minnesota, St. Paul, Univ. of Pittsburgh Cancer Inst., Univ. of
So. California Keck Sch. of Med. and Univ. of Pittsburgh Grad.
Sch. of Publ. Hlth.
3:45 289.4
Changes in Dietary Profiles, Markers of
Cardiometabolic Health and Cognitive Function following 12
Weeks of Peanut Consumption. A. Coates, J. Barbour, J.
Buckley, J. Bryan, P. Howe. Univ. of South Australia and Univ.
of Newcastle, Australia.
4:00 289.5
The Effect of Oat Beta-Glucan on Clinical
Lipid Markers for Cardiovascular Disease Risk Reduction: A
Systematic Review & Meta-analysis of Randomized Controlled
Trials. H.V.T. Ho, J.L. Sievenpiper, A.L. Zurbau, S. Blanco
Mejia, E. Jovanovski, F. Au Yeung, A.L. Jenkins, V. Vuksan.
St. Michael’s Hosp., Toronto.
4:15 289.6
Effect of 3 Probiotic Strains on Bile Acids and
Glucose Metabolism in Healthy Adults: A Randomized, DoubleBlind Placebo-Controlled Crossover Study. T. Culpepper, C.C.
Rowe, C. Nieves, S-A. Girard, M. Christman, S. Chung,
T.A. Thompkins, B. Langkamp-Henken. Univ. of Florida,
Lallemand Hlth. Solutions, Montreal, MCC Stat. Consulting
LLC, Gainesville and Univ. of Nebraska-Lincoln.
4:30 289.7
Probiotic Lacidofil® STRONG Mitigates the
Antibiotic-Induced Alteration of the Fecal MicroRNA Signature
in Healthy Humans. A. Taibi, E.M. Comelli, S-A. Girard, T.A.
Tompkins. Univ. of Toronto, Ctr. for Child Nutr. and Hlth.,
Toronto and Lallemand Hlth. Solutions, Monreal.
4:45 289.8
Preclinical and Clinical Trials for Investigating
the Effect of A1 versus A2 Beta-Casein Containing Diet on
Glutathione Antioxidant Status. M.S. Trivedi, R. Deth, Y.
Zhang. Nova Southeastern Univ. and Northeastern Univ.
Chaired: L. Troy
Cochaired: A.E. Millen
3:00 290.1
Prospective Relations between Red Blood Cell
n-6 and n-3 Fatty Acid Composition and Cognitive Function
among Older Puerto Rican Adults. S.J. Bigornia, T.M. Scott,
W.S. Harris, K.L. Tucker. Univ. of Massachusetts Lowell, USDA
at Tufts Univ. and Sanford Sch. of Med., Univ. of South Dakota.
3:15 290.2
Plasma PLP Concentration and Depressive
Symptomatology in Older Latino Adults: A Longitudinal Analysis
with Time-Varying Covariates. S.P. Arevalo, T.E. Scott, L.M.
Falcon, K.L. Tucker. Univ. of Massachusetts Lowell and Tufts
Univ. Sch. of Med.
3:30 290.3
A Folate, Vitamin B12 and HomocysteineRelated Dietary Pattern and Risk of Subclinical Atherosclerosis:
Findings from the MRC National Survey of Health and
Development. J. Maddock, G.L. Ambrosini, S. Ray, NSHD
Study Team. MRC Human Nutr. Res., Univ. of Cambridge,
Univ. of Western Australia Sch. of Popul. Hlth. and Univ.
Col. London.
3:45 290.4
Plasma
trans
Palmitoleic
Acid
and
Cardiometabolic Risk Factors in Youth with Type 1 Diabetes:
SEARCH Nutrition Ancillary Study. N.S. The, I.B. King, J.L.
Crandell, S. Couch, B. Tzeel, A.D. Liese, D. Dabelea, E.
Mayer-Davis. Furman Univ., Univ. of New Mexico, Univ.
of North Carolina at Chapel Hill, Univ. of Cincinnati Col. of
Allied Hlth., Univ. of South Carolina and Univ. of Colorado
Denver, Aurora.
4:00 290.5
Protein Intake and Risk of Hip Fractures in
Post-Menopausal Women and Men Over 50 Years. T. Fung, W.
Willett, D. Feskanich. Simmons Col., Harvard T.H. Chan Sch.
of Publ. Hlth. and Channing Div. of Network Med., Boston.
4:15 290.6
Vitamin D and Ovarian Reserve and
Fecundability among Women with Proven Fecundity.
S.L. Mumford, R. Silver, L.A. Sjaarda, N. Galai, J. Stanford,
A. Lynch, L. Lesher, N. Perkins, J. Wactawski-Wende, R.
Garbose, K. Kim, K. Michels, E. Schisterman. NICHD, NIH,
Rockville, MD, Univ. of Utah, Univ. of Haifa, Univ. of Colorado
Aurora, Univ. at Buffalo and Johns Hopkins Univ.
4:30 290.7
Calibrated Total Sugars Intake and Risk of
Type 2 Diabetes in the Women’s Health Initiative Observational
Study. N. Tasevska, M. Pettinger, V. Kipnis, D. Midthune, L.
Tinker, N. Potischman, M. Neuhouser, J. Beasley, L. Van
Horn, B. Howard, S. Liu, J. Manson, J. Shikany, C. Thomson,
R. Prentice. Arizona State Univ., Fred Hutchinson Cancer Res.
Ctr., NCI, NIH, Albert Einstein Col. of Med., Northwestern Univ.,
Chicago, Medstar Hlth. Res. Inst., Hyattsville, MD, Brown Univ.,
Harvard Med. Sch., Univ. of Alabama at Birmingham and Univ.
of Arizona.
4:45 290.8
Eating Episodes and Low Calorie Sweetener
Intake in the U.S. Adult Population: NHANES 20072012. B.P. Marriott, K.J. Hunt, A.M. Malek, D. Greenberg, J.
St. Peter. Med. Univ. of South Carolina and PepsiCo, NY
87
M
O
N
NUTRITIONMONDAY
OBESITY AND THE METABOLIC SYNDROME
(CO-SPONSOR: OBESITY RIS)
292. VITMIN: MICRONUTRIENT INTERVENTION
AND TRACE ELEMENT TRANSPORT AND
HOMEOSTASIS IN HEALTH AND DISEASE
Minisymposium
Minisymposium
Chaired: B. Piccolo
Chaired: N. Gletsu-Miller
Cochaired: E. Reverri
Cochaired: J.K. Urbanek
3:00 291.1
Protection against Insulin Resistance in
Obesity Is Accompanied by Low Rates of Systemic Fatty
Acid Mobilization and Attenuated Markers of Fibrosis and
Inflammation in Adipose Tissue. D.W. Van Pelt, A.Y. Wang, J.F.
Horowitz. Univ. of Michigan.
3:15 291.2
High-Fat Diet-Induced Obesity Suppresses
Adaptive Thermogenesis via Toll-Like Receptor 4-Mediated
Endoplasmic Reticulum Stress. M. Okla, W. Wang, S. Chung.
Univ. of Nebraska-Lincoln.
3:30 291.3
A High Fat Diet Containing Fish Oil Reduces
Weight Gain and Metabolic Syndrome Associated with
Glucocorticoid Therapy. M. van der Merwe, L. Beech, S.
Godwin, R. Buddington, K. Ringwald-Smith. Sch. of Hlth.
Studies, Univ. of Memphis and St Jude Children’s Res. Hosp.
3:45 291.4
Effect of Caloric Restriction and Dietary
Composition on Liver Triglyceride Content in Subjects with
Abdominal Obesity: The Wageningen Belly Fat Study.
M. Mensink, S. Schutte, I. Chatindiara, D. Esser, E. Siebelink,
L. Afman. Wageningen Univ., Netherlands.
4:00 291.5
Intake of Genistein and Daidzein Ameliorates
Adiposity and Metabolic Syndrome in High Fat Fed
C57BL/6JMice. T. Luo, O. Miranda, A. Adamson, N.F. Shay.
Oregon State Univ.
4:15 291.6
High Phosphorus Diet Mitigates Impairments
in Lipid and Glucose Metabolism Associated with Diet-Induced
Obesity in Male Sprague Dawley Rats. M. Bassil, N. Zeeni,
N. Farran, O. Obeid. Lebanese American Univ. and American
Univ. of Beirut.
4:30 291.7
A Short-Term Transition from a High-Fat Diet
to a Normal-Fat Diet before Pregnancy Exacerbates Female
Mouse Offspring Obesity. L. Xie, Q. Fu, P. Olson, K. Zhang.
Univ. of North Dakota and Wuhan, China.
4:45 291.8
Disparities in the Incidence of Hypertension
in Youth. C. Koebnick, M.F. Daley, Y.D. Mohan, K. Reynolds,
X. Li, M.A. Sidell, A.H. Porter, J. Handler, S.R. Daniels,
B.D. Kuizon. Kaiser Permanente So. California, Pasadena,
Kaiser Permanente Colorado, Denver, Kaiser Permanente Los
Angeles Med. Ctr., Kaiser Permanente Anaheim Med. Ctr. and
Children’s Hosp. Colorado, Aurora.
3:00 292.1
Lack of Intestinal Divalent Metal-Ion
Transporter 1 Perturbs Copper Homeostasis in Mice. X. Wang,
S. Flores, J-H. Ha, C. Doguer, J.F. Collins. Univ. of Florida.
3:15 292.2
Responses of Total and Bioavailable
25-Hydroxyvitamin D and Factors Modifying the Responses:
A Randomized, Placebo-Controlled Trial of Vitamin D3
Supplementation in an Asian Population. X. Lin, P. Yao, L. Sun,
H. Li. Shanghai Insts. for Biol. Sci., CAS.
3:30 292.3
Hepcidin Attenuates Zinc Efflux in Caco-2
Cells. S.R. Hennigar, J.P. McClung. U.S. Army Res. Inst. of
Envrn. Med., Natick, MA.
3:45 292.4
High Dietary Iron Intake Impairs Growth and
Causes Copper Deficiency in Sprague-Dawley Rats. J-H. Ha,
C. Doguer, S. Zhao, X. Wang, S.R. Flores, J.F. Collins. Univ.
of Florida.
4:00 292.5
Iron Status and Regulation in High-Risk
Pregnant African American Women. L. Welke. Univ. of Illinois
at Chicago.
4:15 292.6
The Ferroxidase Hephaestin Is Required for
Optimal Iron Absorption in Weanling Mice, but Is Dispensable
for Enhanced Iron Absorption in Adults. C. Doguer, J-H. Ha, M.
Alla, J.F. Collins. Univ. of Florida
4:30 292.7
Trace Element Distribution in Flatiron Mice, a
Genetic Model of Human Ferroportin Disease. Y.A. Seo, M.
Wessling-Resnick. Harvard Sch. of Publ. Hlth.
4:45 292.8
Impact
of
Milk-Based
Micronutrient
Supplementation on Zinc, Iron, and Vitamin A Deficiencies in
School Children in Quito, Ecuador. D. Guevara, S. Reyes, D.
Anarumba, M. López, S. Cevallos, E. Montenegro, N. Flores,
M. Fornasini, M.E. Baldeon. Univ. de las Americas, Ecuador
293. AGING: NUTRITION AND
CARDIOMETABOLIC HEALTH
Minisymposium
Chaired: C.C. Tangney
Cochaired: K. Starr
3:00 293.1
Effects of Polyphenolic-Rich Dark Chocolate
and Almonds on Cardiovascular Risk Factors in Overweight
and Obese Adults. Y. Lee, C. Berryman, S. West, C-Y.O. Chen,
J. Blumberg, A. Preston, K. Lapsley, J. Fleming, P. KrisEtherton. Penn State, USDA at Tufts Univ., Hershey Co., PA
and Almond Bd. of California, Modesto.
3:15 293.2
Incorporation of Almonds in a CholesterolLowering Diet Improves Non-ABCA1-Mediated Cholesterol
Efflux in Normal Weight Adults. C.E. Berryman, J.A. Fleming,
P.M. Kris-Etherton. Penn State
88
MONDAYNUTRITION
3:30 293.3
Daily Almond Consumption Reduces Fasting
Total, LDL and non-HDL Cholesterol and Body Fat Mass in
Healthy Young Korean Subjects: A Randomized Controlled
Trial. H. Park, Y. Liu, Y. Song, H-S. Kim. ICAN Nutr. Educ. and
Res., Seoul and Sookmyung Women’s Univ., South Korea.
3:45 293.4
Effect of a 1-Year Walnut Supplementation
on Blood Lipids among Older Individuals: Findings from the
Walnuts and Healthy Aging Study. E. Ros, S. Rajaram, A.
Sala-Vila, M. Serra-Mir, C. Valls-Pedret, M. Cofán, I. Roth, M.
Doménech, T. Freitas, C. Calvo, E. Haddad, J. Sabaté. Hosp.
Clin., Barcelona and Loma Linda Univ.
4:00 293.5
Adherence to a Mediterranean Diet, and
Effects on Cardiometabolic Health in Older Australian:; Results
from the MedIterranean Diet for Cognition and Cardiovascular
Health in the Elderly (MedLey) Trial. C.R. Davis, J. Bryan,
C. Wilson, J. Hodgson, R. Woodman, K. Murphy. Univ.
of South Australia, Sch. of Med., Flinders Univ. and Univ. of
Western Australia.
4:15 293.6
Validation of a Sodium Screener in Two
Samples. C.C. Tangney, H.C. Rasmussen, J. Rusch, O.
Moss, L.A. Cerwinske, C. Richards, M. Li, B.M. Appelhans.
Rush Univ. Med. Ctr.
4:30 293.7
Ldlr-/- Mice Lacking PEMT Have Elevated
Plasma Trimethylamine-Oxide Levels but Are Protected from
High Fat Diet-Induced Atherosclerosis. R. Jacobs, Y. Zia, A.
Rajabi, S. Mi, K-A. Leonard, Y-Y. Zhao, C. Field, J. Curtis, J.
van der Veen. Univ. of Alberta.
4:45 293.8
Inactive Matrix Gla Protein Is Associated with
Arterial Stiffness and Vascular Endothelial Function in AfricanAmerican Hemodialysis Patients. M.E. Fain, J. Nguyen, G.K.
Kapuku, W.D. Paulson, J.J. White, Y. Dong, N.K. Pollock.
Med. Col. of Georgia, Georgia Regents Univ.
294. GLOBAL NUTRITION: IMPROVING
INFANT FEEDING PRACTICES OF
VULNERABLE POPULATIONS
3:30 294.3
Complementary Feeding Is Positively Related
with Family Care, Care for Women, and Improved Water and
Sanitation among Populations. S. Basnet, E.A. Frongillo, S.
Kulkarni, F. de Castro. Univ. of South Carolina and Mexico
Natl. Inst. of Publ. Hlth., Cuernavaca.
3:45 294.4
Differences in Child Feeding and Handwashing
Practices within the Context of a Randomized Controlled Trial of
Nutrition, Water, Sanitation, and Hygiene Interventions among
Low-Income Bangladeshi Mothers. K. Jannat, S.P. Luby, L.
Unicomb, K.K. Das, E. Leontsini, M. Rahman, P. Winch, C.
Stewart. icddr, Bangladesh, Stanford Univ., Johns Hopkins
Bloomberg Sch. of Publ. Hlth. and Univ. of California Davis.
4:00 294.5
Food Sources of Total Energy, Total Sugars
and Added Sugars among Infants, Toddlers and Preschoolers
Living in Mexico: Findings from the 2012 Mexican National
Health and Nutrition Survey. D. Deming, M. Afeiche, K. Reidy,
A. Eldridge, S. Villalpando-Carrión. Nestlé Nutr. Global R&D,
NJ, Nestle Res. Ctr., Lausanne, Children’s Hosp. of Mexico
and Nestlé Infant Nutr., Mexico City.
4:15 294.6
Snacking Starts Early and Is Prevalent among
Infants, Toddlers and Preschoolers in Mexico. D. Deming, M.
Afeiche, K. Reidy, A. Eldridge, S. Villalpando-Carrión. Nestlé
Nutr. Global R&D, Floral Park, NJ, Nestle Res. Ctr., Lausanne,
Children’s Hosp. of Mexico, Natl. Inst. of Hlth., Mexico City and
Nestlé Infant Nutr., Mexico City.
4:30 294.7
Household Food Insecurity and Complementary
Feeding in Malawi. E. Faerber, J. Weiss, E. Kedera, A.
Webb Girard. Emory Univ. and Concern Worldwide/US, New
York, NY.
4:45
Conclusion.
EARLY CHILDHOOD NUTRITION
Minisymposium
Minisymposium
Chaired: D. Sela
(Cosponsored by: Maternal, Perinatal and Pediatric RIS)
Cochaired: E. Jantscher-Krenn
Chaired: M.E. Bentley
Cochaired: S. Syed
3:00 294.1
Modeling Pathways from a Behavior Change
Communications Intervention to Complementary Feeding
Outcomes: A Proof of Concept Study. A. Zongrone, P. Menon,
G. Pelto, J-P. Habicht, K.M. Rasmussen, M. Constas, A.
Khaled, K.K. Saha, R.J. Stoltzfus. IFPRI, Washington, DC,
Cornell Univ. and BRAC Univ., Bangladesh.
3:15 294.2
A Large-Scale Behavior Change Initiative
to Improve Infant and Young Child Feeding Had Positive
Impact on Language and Motor Development in Bangladesh.
E. Frongillo, P. Nguyen, K. Saha, T. Sanghvi, K. Afsana,
R. Haque, J. Baker, M. Ruel, R. Rawat, P. Menon. Univ. of
South Carolina, IFPRI and FHI360, Washington, DC and
BRAC, Bangladesh.
3:00 295.1
From Carrots to Peas and Parsnips:
Programming Flexibility through Guided Multisensory
Exploration in an Early Childhood Environment. S. Kannan,
H.B. Ganguri, Z. Qamar, U. Lakshmanan, C. Wittcopp. So.
Illinois Univ. Carbondale, Kronsys, Raleigh, Texas A&M Univ.
and Baystate Med. Ctr., Springfield, MA.
3:15 295.2
INSIGHT Study Parenting Intervention to
Prevent Childhood Obesity Improves Patterns of Dietary
Exposures in Infants. E.E. Hohman, J.S. Savage, I.M. Paul,
L.L. Birch. Penn State, Penn State Col. of Med. and Univ.
of Georgia.
3:30 295.3
Parental
Knowledge,
Perceptions
and
Consumption of Milk and Alternatives Relates to Intakes of
Young Children 2-8 Years of Age. N.R. Brett, C.A. Vanstone,
J.L. Maguire, F. Rauch, H.A. Weiler. Sch. of Dietet. and Human
Nutr., McGill Univ., Li Ka Shing Inst. of St. Michael’s Hosp.,
Univ. of Toronto and Shriners Hosp. for Children, Montreal.
3:45 295.4
Preschool Children’s Food Involvement Is
Related to Fruit and Vegetable Intake. J.M. Jarick, B.H. Fiese.
Univ. of Illinois at Urbana-Champaign.
89
M
O
N
NUTRITIONMONDAY
4:00 295.5
Effects of Omega-3 Supplementation during
Pregnancy and Youth on Neurodevelopment and Cognition
in Childhood: A Systematic Review and Meta-analysis. M.L.
Shulkin, L. Pimpin, D. Bellinger, S. Kranz, C. Duggan, W.
Fawzi, D. Mozaffarian. Friedman Sch. of Nutr. Sci. and Policy,
Tufts Univ., Boston Children’s Hosp., Harvard Med. Sch. and
Harvard T.H. Chan Sch. of Publ. Hlth.
4:15 295.6
Infant Feeding Practices in a Diverse Group of
Women: The Healthy Start Study. J.L. Kaar, K.A. Sauder, T.L.
Crume, A.L.B. Shapiro, A.P. Starling, D. Dabelea. Sch. of Med.
and Colorado Sch. of Publ. Hlth., Univ. of Colorado, Aurora.
4:30 295.7
The Early Life Predictors of a Dietary Pattern
Linked with Greater Metabolic Risk in Adolescence and
Tracking of Its Food Components. G. Appannah, G.K. Pot,
W.H. Oddy, S.A. Jebb, G.L. Ambrosini. Univ. Putra Malaysia,
MRC Human Nutr. Res., Cambridge, Sch. of Med., King’s Col.
London, VU Univ. Amsterdam Fac. of Earth and Life Sci., Univ.
of Western Australia and Univ. of Oxford
4:45 295.8
Iron Status Predicts EEG Measures of Brain
Function during a Memory Task in 4-6 Month Old Infants
and May Reveal Associations between Early Iron Status
and Memory Behavior. J.E.H. Nevins, S.S. Robertson, R.L.
Canfield, J.D. Haas. Cornell Univ.
4:15 296.6
Feeding a Maternal Diet Enriched in
Docosahexaenoic Acid to Lactating Dams Improves the Ex
Vivo Tolerance Response to Egg Protein in Suckled Pups.
C. Richard, E.D. Lewis, S. Goruk, C.J. Field. Univ. of Alberta.
4:30 296.7
Effects of a Randomized, Controlled Trial
of Daily Vitamin D3 Supplementation during Pregnancy on
Regulatory Immunity and Inflammation. M. Zerofsky, B.
Jacoby, T.L. Pedersen, C.B. Stephensen. USDA, Davis and
UC Davis Med. Ctr., Sacramento.
4:45 296.8
Effect of a Diet Rich in Whole Grains on
Gut Microbiota, and Immune and Inflammatory Markers of
Healthy Adults. S.M. Vanegas, M. Meydani, J.B. Barnett, A.
Kane, B. Goldin, D. Wu, J.P. Karl, C. Brown, P. Vangay, D.
Knights, L. Li, S.S. Jonnalagadda, M. Thomas, E. Satlzman,
S.N. Meydani. USDA and Sch. of Med., Tufts Univ., Univ. of
Minnesota, Minneapolis and General Mills, Minneapolis.
297. JOINT EVENT: COMMUNITY AND PUBLIC
HEALTH AND, NUTRITION EDUCATION AND
BEHAVIORAL SCIENCE RIS BUSINESS
MEETING AND SPEED NETWORKING SESSION
RIS Forum
Science RIS)
296. NUTRITION IMMUNOLOGY, INFECTION
AND INFLAMMATION
Minisymposium
(Cosponsored by: Community and Public Health
Nutrition RIS)
(Sponsored by: Nutritional Immunology RIS)
Mon. 3:00 pm—San Diego Convention Center, Room 28DE
Mon. 3:00 pm—San Diego Convention Center, Room 30D
Chaired: E.A. Karlsson
Cochaired: S. Colby
Cochaired: S. Comstock
3:00 296.1
Formula Diet-Driven Microbial Diversity and
Immunological Consequence in Small Intestine of Neonatal
Porcine Model. V.L. Yeruva, N. Spencer, A.K. Bowlin, S.V.
Chintapalli, K. Shankar, L. Hennings, M.A. Cleves, M. Saraf,
T.M. Badger, M.J. Ronis. Arkansas Children’s Nutr. Ctr. and
LSU, New Orleans.
3:15 296.2
Anemia and Iron Status Are Predictors of
Gut Microbiome Composition and Metabolites in Infants
and Children in Rural Kenya. D. Paganini, T. Jaeggi, C.
Cercamondi, P. Kujinga, D. Moretti, M. Zimmermann. ETH
Zurich and Wageningen Univ., Netherlands.
3:30 296.3
Offspring Immune Development Is Dependent
on the Amount and Form of Choline in the Maternal Diet during
Suckling. E.D. Lewis, C. Richard, S. Goruk, N. Dellschaft,
J.M. Curtis, R.L. Jacobs, C.J. Field. Univ. of Alberta.
3:45 296.4
The Impact of Environmental Enteropathy and
Systemic Inflammation on Infant Growth Failure. C. Naylor, M.
Lu, J.A. Ma, A.M. Prentice, W.A. Petri. MRC Unit, The Gambia,
Univ. of Virginia and London Sch. of Hyg. and Trop. Med.
4:00 296.5
Monounsaturated
Fatty
Acids
Impede
Inflammation Partially through Activation of AMPK. C.L. Lyons,
O.F. Finucane, A.M. Murphy, A.A. Cooke, B. Viollet, P.M.
Vieira, W. Oldham, B.B. Kahn, H.M. Roche. Conway Inst. of
Biomolec. and Biomed. Res., Dublin, Inst. Cochin, INSERM,
Paris, Beth Israel Deaconess Med. Ctr., Harvard Med. Sch.
and Brigham and Women’s Hosp.
90
GLOBAL NURITION COUNCIL BUSINESS
MEETING AND KELLOGG PRIZE
FOR INTERNATIONAL NUTRITION
RESEARCH LECTURE
Mon. 6:30 pm—Hilton San Diego Bayfront, Indigo AE
M.E. Bentley. Univ. of North Carolina at Chapel Hill
EB 2016?
MONDAYPATHOLOGY
Pathology
298. ASIP 2016 TOWN HALL MEETING
Special Session
Back By Popular Demand...The ASIP 2016 Town Hall Meeting!
Join us for breakfast on Monday, April 4, 2016 from 7:00
am until 8:00 am to discuss present and future ASIP benefits,
opportunities available to our members to become more involved
in the Society, and ideas for the future. The ASIP Town Hall Meeting
is a chance for you to meet with ASIP’s Director of Membership,
Membership Committee Chair, and other ASIP Leadership and to
express your thoughts, ideas, and opinions. Is there a member
benefit you would like for us to offer? Are you interested in working
more closely with the ASIP Leadership? Why not share your
comments and suggestions over a cup of coffee. Make plans now
to join the discussion…registration is NOT required!
11:15 300.2
Nucleoside Reverse Transcriptase Inhibitors
Attenuate Angiogenesis and Lymphangiogenesis by Impairing
Receptor Tyrosine Kinases Signaling in Endothelial Cells.
L. Song, X. Zhu, C. Qiu, L. Qin, S.A. Chow, L. Yu. Zhejiang
Univ., China, Yale Univ. Sch. of Med., UCLA.
301. ACVP SYMPOSIUM: ILLUMINATING
PATHOBIOLOGY: IMAGING ACROSS SCALE
Symposium
(Sponsored by: the ASIP Veterinary and Comparative
Pathology Scientific Interest Group and the American
College of Veterinary Pathologists)
Chaired: R. Sullivan
Cochaired: S. Fossey and R. Johnson
299. ASIP COTRAN EARLY CAREER INVESTIGATOR
AWARD LECTURE
Veterinary and Comparative Pathology
Breast Cancer
Award Lecture
ASIP Cotran Early Career Investigator Award Lecture:
How Metabolism Regulates Retinal Function:
Implications for Prevention of Disease. M. SaintGeniez. Schepens Eye Research Inst.
300. BLOOD VESSEL CLUB™: ANGIOGENSIS IN
ORGAN DEVELOPMENT AND FUNCTION
Symposium
M
O
N
8:30
Multiscale Imaging of Cellular Microenvironments.
K. Eliceiri. Univ. of Wisconsin-Madison.
9:05
Living Imaging of the Mouse Bone Marrow by Intravital
Microscopy. C. Lin. Harvard Univ.
9:40 In Vivo Metabolic Imaging to Discern Tumor and
Stromal Cells in the Breast Tumor Microenvironment.
J. Szulczewski. Univ. of Wisconsin-Madison.
10:15 Manual Pathology Scoring – The Gold-Standard
Paradox. F. Aeffner. Flagship Biosciences Inc.,
Westminster, CO.
10:50 Translational Imaging Techniques. M. Rosol. Novartis AG.
302. SIPMET SYMPOSIUM: SEX STEROID
HORMONES ACTION IN METABOLISM,
DIFFERENTIATION, AND DAMAGE RESPONSE
Chaired: D. Bielenberg
Symposium
Cochaired: K. Moulton
(Sponsored by: ASIP and the Società Italiana di Patologia
e Medicina Traslazionale /Italian Society of Pathology
and Translational Medicine)
Vascular Biology
8:30
ASIP Cotran Early Career Investigator
Award Lecture: How Metabolism Regulates Retinal Function:
Implications for Prevention of Disease. M. Saint-Geniez.
Schepens Eye Research Inst.
9:30
Molecular Regulation of Vascular Permeability.
C. Kuo. Stanford Univ. Sch. of Med.
10:15
Notch Signaling in Arteriovenous Differentiation
and Disease. R. Wang. UCSF.
11:00 300.1
Endothelial Follistatin-Like 1 Regulates the
Maturation of the Pulmonary Vasculature by Modulating BMP/
Smad Signaling. N.P. Tania, H. Maarsingh, S.T. Bos, A. Mattiotti,
S. Prakash, W.Timens, M. Schmidt, M. van den Hoff, R. Gosens.
Univ. of Groningen, Palm Beach Atlantic Univ., Academic Med.
Ctr., Amsterdam and Univ. Med. Ctr. Groningen, Netherlands.
Chaired: A. Migliaccio
Cochaired: A. Rogers
8:30
9:15
New Insights into Estrogen Signaling. M. Baker. UCSD.
Hormonal Regulation of Sex-Specific Liver Diseases.
A. Rogers. Tufts Univ.
10:00 Cross-Talk between Androgen Receptor and NGF
Receptor (Trka) in Neuronal Cells. A. Migliaccio.
State Univ. of Naples.
10:45 Androgen Signaling in Skeletal Muscle. D. Metzger.
IGBMC, Illkirch, France.
91
PATHOLOGYMONDAY
303. STOWELL SYMPOSIUM/TRENDS IN
EXPERIMENTAL PATHOLOGY: THE
SCIENCE OF HEALTH DISPARITIES: NEW
PARADIGMS, APPROACHES AND IMPACT ON
DISEASE PREVENTION
8:30
9:15
10:00
10:45
Chaired: S. Colgan
Cochaired: V. Spindler
Chaired: K. Gardner
Transporters/Channels/Barriers
Cochaired: C. Yates
KEYNOTE LECTURE: What Creates Health Disparities?
P. Braveman. UCSF.
Epigenetics in Cancer Health Disparities. C. Yates.
Tuskegee Univ.
Can Genome Sciences Help Increase Our Understanding
of the Role of Biology in Cancer Health Disparities?
Towards Improvements in Clinical Management of
Cancer Through Precision Medicine. J. Carpten.
Translational Genomics Res. Inst., Phoenix.
Analysis of Tumor Biology to Advance Cancer Health
Disparity Research. S. Ambs. NCI, NIH.
Symposium
(Supported by an unrestricted educational grant from
Friends for an Earlier Breast Cancer Test)
(Sponsored by: earlier.org)
Chaired: W.B. Coleman
Cancer Biology
Neoplasia
Identification of Drivers of Triple-Negative Breast Cancer.
J. Reis-Filho. Mem. Sloan Kettering Cancer Ctr.
2:55 Target Discovery through Next-Gen Sequencing
of Triple-Negative Breast Cancer. G. Tsongalis.
Dartmouth-Hitchcock Med. Ctr.
3:50 Exploitation of Molecular Features to Personalize
Therapeutic Approaches in Triple-Negative Breast
Cancer. C. Anders. Univ. of North Carolina Lineberger
Comprehensive Cancer Ctr.
92
Minisymposium
Symposium
304. ASIP PRESIDENTIAL SYMPOSIUM:
MOLECULAR PATHOGENESIS OF TRIPLENEGATIVE BREAST CANCER: IMPLICATIONS
FOR PREVENTION AND THERAPY
2:00
305. EPITHELIAL JUNCTIONS, CELL MIGRATION
AND TISSUE REPAIR
2:00 305.1
Loss of Dsg2 Promotes Tumorigenesis in
Pancreatic Cancer Cells through ERK Activation. K. Huetz, J.
Waschke, V. Spindler. Ludwig Maximilians Univ. Munich
2:15 305.2
Central Role for Intestinal Epithelial IL-10R1
Signaling in Barrier Restitution. J.M. Lanis, E.E. Alexeev,
D.J. Kao, D.A. Kitzenberg, K.D. Schwisow, D.J. Kominsky,
S.P. Colgan. Univ. of Colorado Anschutz Med. Campus and
Montana State Univ.
2:30 305.3
Redundant Role of Catenins in Maintaining
Tight Junctional Integrity. T. Pradhan-Sundd, L. Zhou, A.
Jiang, J.O. Russell, S. Singh, M. Poddar, S. Ranganathan,
K. Nejak-Bowen, S. Singh Pal Monga. Univ. of Pittsburgh.
2:45 305.4
Keratin Filaments Regulate Binding Properties
of the Desmosomal Adhesion Molecule Desmoglein 3.
F. Vielmuth, F. Loschke, T.M. Magin, J. Waschke, V. Spindler.
Ludwig Maximilians Univ. Munich and Univ. of Leipzig.
3:00 305.5
Vesicle Fusion Protein, YKT6, Is a Novel
Regulator of Epithelial Cell-Matrix Adhesion and Migration.
A. Ivanov, N. Naydenov, S. Joshi, A. Feygin. Virginia
Commonwealth Univ.
3:15 305.6
Intestinal Epithelial Cell Expression of CD47
Facilitates Proliferation, Neutrophil Transmigration, and Wound
Healing In Vivo. M. Reed, A-C. Luissint, A. Nusrat, C.A.
Parkos. Univ. of Michigan.
3:30 305.7
The Specialized Pro-resolving Lipid Mediator
Resolvin E1 Promotes Intestinal Mucosal Wound Repair.
M. Quiros, H. Nishio, G. Leoni, R. Agarwal, G. Bernal, C.
Gerner-Smith, C. Gerner-Smith, R. Colas, K. Graham, C.
Serhan, A. Garcia, C. Parkos, A. Nusrat. Univ. of Michigan,
Inst. for Cardiovasc. Prevent., Munich, Georgia Tech, Emory
Univ. and Harvard Univ.
3:45 305.8
Cortactin Is Required to Maintain Intestinal
Epithelial Barrier Homeostasis. A.F. Citalán-Madrid, A. GarcíaPonce, H. Vargas-Robles, A. Betanzos, P. Nava, K. Rottner,
R. Menningen, M. Schnoor. CINVESTAV-IPN, Mexico City,
Tech Univ. Braunschweig and Univ. Hosp. Münster, Germany.
4:00 305.9
Sympathetic
Signaling
Regulates
Cardiomyocyte Cohesion via the Plaque Protein Plakoglobin.
C. Schinner, A. Schlipp, V. Rötzer, F. Vielmuth, A. Messoudi,
A. Horn, V. Spindler, J. Waschke. Ludwig Maximilians
Univ. Munich.
4:15 305.10 Role of Hypoxia-Inducible Factor on Colonic
Goblet Cell Differentiation and Function during Mucosal
Healing. A.K. Whitney, K.D. Schwisow, A.J. Bayless, L.
Golden-Mason, G. Mehta, K.A. Kuhn, S.P. Colgan, E.L.
Campbell. Univ. of Colorado Anschutz Med. Campus.
MONDAYPATHOLOGY
4:30 305.11 Transgenic Up-Regulation of Claudin-6
Decreases Diesel Particulate Matter-Induced Pulmonary
Inflammation. J. Bodine, J. Gassman, D.C. Milner, A. Lewis,
T. Dunaway, K. Egbert, C. Christiansen, A. Christiansen,
T. Monson, D. Broberg, J. Arroyo, P.R. Reynolds. Brigham
Young Univ.
4:45 305.12 Altered Inflammatory Responses in Tobacco
Smoke-Exposed Mice That Over-Express the Tight Junctional
Protein Claudin-6. J.B. Lewis, J. Bodine, D. Milner, A. Lewis,
T. Dunaway, K. Egbert, S. Albright, B. Merrill, T. Monson, M.
Watson, N. Burstedt, Q. Smith, J. Gassman, T. Jergensen, B.
Chavarria, D. Broberg, D. Thomas, J. Arroyo, P.R. Reynolds.
Brigham Young Univ.
306. MECHANISMS OF MYOCARDIAL FAILURE
AND FIBROSIS
Minisymposium
Chaired: J. Schisler
Cochaired: T. Nevers
Cardiac Pathobiology
2:00
Introduction.
2:10 306.1
The Role of miR-378*, miR-218 and miR-351
in Cardiac Hypertrophy. S. Sadiq, F.J. Charchar, T. Crowley, L.
Delbridge, S. Harrap, P. Lewandowski. Sch. of Med., Deakin
Univ., Federation Univ. and Univ. of Melbourne, Australia.
2:25 306.2
Resolution Agonist 15-epi-Lipoxin A4 Directs
FPR2 to Expedite Healing Phase Post-myocardial Infarction.
V. Kain, F. Liu, V. Kozlovskaya, K.A. Ingle, S. Khedkar, S.D.
Prabhu, E. Kharlampieva, G.V. Halade. Univ. of Alabama at
Birmingham and Chembio Discovery Solutions, Boston.
2:40 306.3
Nebulized Delivery of the MAPKAP Kinase 2
Peptide Inhibitor MMI-0100 Protects against Ischemia-Induced
Systolic Dysfunction. D. Brown, B. Cooley, M. Quintana, C.
Landers, M.S. Willis. Univ. of North Carolina at Chapel Hill and
Moerae Matrix, NJ.
2:55 306.4
Activation of TRPVv1 by 12(S)-HpETE and
20-HETE Releases CGRP and Protects the Heart against the
Cardiac Dysfunction Caused by LPS. J. Chen, A.J.P. Hamers,
M. Finsterbusch, C. Thiemermann, A. Ahluwalia. Barts
and The London Sch. of Med. and Dent., Queen Mary Univ.
of London.
3:10 306.5
Pharmacological Inhibition of p38/MAPK
Improves Cardiac Function in Cardiac-Specific Bag3-P209L
Transgenic Mice. S.C. Eaton, S. Takayama, T.N. Sidorova,
K.T. Murray, M.S. Willis. Univ. of North Carolina at Chapel Hill,
Boston Univ. and Vanderbilt Univ.
3:25 306.6
Intercellular Adhesion Molecule 1 Regulates
Left Ventricular Leukocyte Recruitment, Cardiac Remodeling
and Function in Pressure Overload-Induced Heart Failure.
A.M. Salvador, T. Nevers, M. Aronovitz, B. Wang, I. Jaffe, R.
Blanton, P. Alcaide. Tufts Med. Ctr.
3:40 306.7
Th1 Effector T Cells Induce Cardiac Fibroblasts
Transition to Myofibroblasts and Contribute to Pressure
Overload-Induced Cardiac Fibrosis. T. Nevers, A.M. Salvador,
F. Velazquez, M. Aronovitz, R. Blanton, P. Alcaide. Tufts
Med. Ctr. and Tufts Univ.
3:55 306.8
Fenofibrate Induces Cardiac Fibrosis in Mice
Lacking the Co-chaperone and E3-Ubiquitin Ligase CHIP. S.
Ravi, M.S. Willis, P. Lockyer, C. Patterson, J.C. Schisler.
Univ. of North Carolina at Chapel Hill.
4:10 306.9
Prostaglandin
E2
Inhibits
Monocyte
Chemotactic Protein 5 Production and Secretion in Mouse
Cardiac Fibroblasts via EP4 Receptor. T.D. Bryson, D.
Szandzik, P. Harding. Henry Ford Hlth. Syst. and Wayne State
Univ. Sch. of Med.
307. SUGAR, SUGAR, AWWW, HONEY, HONEY...
PATHOPHYSIOLOGY OF DIABETES, OBESITY
AND METABOLIC COMPLICATIONS
Minisymposium
Chaired: K. Lenhart
Cochaired: M.S. Willis
2:00
Introduction.
2:05 307.1
High Glucose Culture Medium Downregulates
Production of Human β-Defensin-2 in Human Amniotic
Epithelial Cells. D. Szukiewicz, H. Alkhalayla, M. Pyzlak, G.
Szewczyk. Med. Univ. of Warsaw.
2:20 307.2
Insulin Signaling Regulation of Sortilin 1 and
Glut4 Storage Vesicle Formation in NIH 3T3-L1 Adipocytes
and Mouse Adipose Tissue. J. Li, D. Matye, Y. Wang, T. Li.
Univ. of Kansas Med. Ctr.
2:35 307.3
Serum miRNAs as Potential Biomarkers for
Early Prediction of Type 1 Diabetes. C. Yin, M. Weiland, J. Li,
R. She, L. Zhou, Q. Mi. Henry Ford Hlth. Syst.
2:50 307.4
Insulin Treatment Increases Myocardial
Ceramide Accumulation and Disrupts Cardiometabolic Function.
A.E. Hodson, T.S. Tippetts, B.T. Bikman. Brigham Young Univ.
3:05 307.5
Mitochondrial Fission Is Necessary for CeramideInduced Metabolic Disruption. B.T. Bikman. Brigham Young Univ.
3:20 307.6
Pancreatic Trypsin and Insulin Receptor
Cleavage in High Fat Diet Rats. A.S. Courelli, R. Mazor, G.W.
Schmid-Schonbein. UCSD.
3:35 307.7
Loss of CHIP Expression Perturbs Glucose
Homeostasis and Leads to Type II Diabetes through Defects
in Microtubule Polymerization and Glucose Transporter
Localization. K.C. Lenhart, H. McDonough, S.M. Ronnebaum,
J. An, C.B. Newgard, M.S. Willis, C. Patterson, J.C. Schisler.
Univ. of North Carolina at Chapel Hill and Duke Univ.
3:50 307.8
The Role of the Duffy Antigen Receptor for
Chemokines in Metabolic Disease. T.W. Benson, T. Chatterjee,
J. Joseph, O. Popoola, M. Crowe, N. Yiew, D. Unruh, D.
Weintraub, A. Pillai, J. Williams, J. Mintz, B. Stansfield, D.
Stepp, J. Brittain, V. Bogdanov, N. Weintraub. Med. Col. of
Georgia at Augusta Univ. and Univ. of Cincinnati.
4:05 307.9
Augmented
Adipocyte
Browning
and
Mitochondrial Function in Periadrenal Fat but Not Subcutaneous
Fat in Pheochromocytoma Patients. G.R. Davies, L. Vergnes,
M. Yeh, A. Harari, M. Livhits, J. Huang, M. Symonds, K.
Reue, H. Sacks. Univ. of Nottingham, UCLA and VA Greater
Los Angeles Healthcare.
4:20 307.10 Inhibition of Adipocyte and Preadipocyte
Fusion Reduces Abdominal Adipose Tissue Mass in Obese
Mice. X. Yuan, X. Xu, N. Li, W.L. Dewey, P-L. Li, F. Zhang.
Med. Col. of Virginia, VCU.
4:35Discussion.
93
M
O
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PATHOLOGY/PHARMACOLOGYMONDAY
308. ASIP MEMBERSHIP BUSINESS MEETING AND
AWARDS PRESENTATION
309. ASIP AWARDS RECEPTION
Special Session
Business Meeting
Mon. 6:30 pm—San Diego Convention Center, Room
6A Foyer
Pharmacology
310. JOHN J. ABEL AWARD IN
PHARMACOLOGY LECTURE
312. WNT SIGNALING: FROM
DISEASE MECHANISMS TO
THERAPEUTIC INTERVENTIONS
Award Lecture
Symposium
The John J. Abel Award in Pharmacology, named after
the founder of ASPET, was established in 1946 to stimulate
fundamental research in pharmacology and experimental
therapeutics by young investigators.
8:30Introduction.
8:35 Epithelial-Mesenchymal Plasticity
Metastasis. J. Yang. UCSD.
in
(Cosponsored by: The Divisions for Cardiovascular
Pharmacology, Cancer Pharmacology, Translational
and Clinical Pharmacology, and Drug Discovery and
Development )
Carcinoma
Cochaired: R. Gosens and W.M. Blankesteijn
311. HEAR IT FROM THE EDITORS: NAVIGATING THE
COURSE THROUGH JOURNAL SUBMISSION
AND PUBLICATION
Cancer Biology
Symposium
9:30
(Cosponsored by: All ASPET Divisions)
Cochaired: M. Vore and E.T. Morgan
Career Development
9:30
How to Choose a Journal for Your Manuscript? M. Vore.
Univ. of Kentucky.
9:50 How to Write a Competitive Manuscript. M. Jarvis.
AbbVie, Inc.
10:10 Communicating Experimental Design and Analysis
Considerations. E.T. Morgan. Emory Univ.
10:30 The Peer-Review Process: Rejection, Revision, and
Acceptance. S. Traynelis. Emory Univ.
10:50Authorship,
Accountability
and
Ethics.
R.
Dodenhoff. ASPET.
11:10 Panel Discussion. Moderator: D. Sibley. ASPET Board
of Publications Trustees.
Evolution of Wnt Signaling: From Developmental Biology
Towards Therapeutic Application. W.M. Blankesteijn.
Cardiovasc. Res. Inst. Maastricht.
9:40
Receptor-Ligand Selectivity of Wnt/Frizzled Signaling.
G. Schulte. Karolinska Inst.
10:05 Wnt Signal Transduction Pathways in Stem Cells and
Cancer. X. He. Boston Children’s Hosp.
10:30 Wnt Signaling in Respiratory Diseases. M. Königshoff.
CPC Großhadern, Germany.
10:55 Targeting Wnt Signaling in Cardiovascular Diseases.
A. Deb. UCLA.
11:20 Tankyrases Are Druggable Targets for the Treatment of
Metabolic Disorders. O. Obianom, W. Yang, F. Xue, Y.
Shu. Univ. of Maryland Baltimore. (1189.5)
11:33 A Novel Activator of Canonical Wnt Signaling. J. Baruah,
K.K. Wary, R. Hitzman, J. Zhang. Univ. of Illinois at
Chicago. (931.14)
11:46 Structure-Activity Relationship of Peptide Inhibitors
of the Wnt/Frizzled Interaction. W.M. Blankesteijn,
K.C.M. Hermans, A.I. Fernandez-Llamazares, N.
Kriek, P. Timmerman. Maastricht Univ. and Pepscan
Therapeut. Netherlands. (931.13)
Visit the Exhibits
April 3–April 5
Exhibit Hours
94
MONDAYPHARMACOLOGY
313. SUBSTRATE MODULATION OF ORGANIC
ANION AND CATION TRANSPORTERS
Symposium
315. PHARMACOMETABOLOMICS ENABLING
TOOLS FOR SYSTEMS PHARMACOLOGY AND
PRECISION MEDICINE
Symposium
Pharmacology and Cardiovascular Pharmacology )
Cochaired: B. Hagenbuch and J. Lampe
Drug Metabolism
Cochaired: R. Kaddurah-Daouk and R. Weinshilboum
9:30Introduction.
9:40
Substrate and Inhibitor Modulation of Hepatic OCT1
Transport. J. Lampe. Univ. of Kansas Med. Ctr.
10:10 Substrate-Dependent Ligand Interaction with MATE
Transporters. S. Wright. Univ. of Arizona.
10:40 Substrate-Dependent Modulation of OATP1B1 and
OATP1B3. B. Hagenbuch. Univ. of Kansas Med. Ctr.
11:10 Substrate Modulation of Drug Transporters: An Industry
Perspective. C. Lee. Ardea Biosciences.
11:40 Organic Cation Transporters in Drug Interactions with
Methamphetamine and Metabolites. D.J. Wagner, J.
Wang. Univ. of Washington. (935.6)
314. A PHARMACOKINETICS PRIMER: FROM
EQUATIONS TO APPLICATION
Symposium
Pharmacology, Drug Discovery and Development,
Drug Metabolism, Cardiovascular Pharmacology, and
Translational and Clinical Pharmacology )
Chaired: R. Mehvar
Education
This conceptual, less-mathematical pharmacokinetics
primer is designed for a general audience with a background
in Pharmacology or Biomedical Sciences, who use or plan
to use pharmacokinetics in their research or as part of their
instructional responsibilities. In part one, designed for both
researchers and educators, fundamental concepts behind the
major pharmacokinetic parameters, including their estimation
and application will be discussed. Part two will be a more handson session, utilizing simulations and other exercises, which will
be more useful to pharmacology educators. Seating at handson tables is on a first-come basis.
9:30 Fundamental
Concepts
in
Pharmacokinetics:
Applications in Research and Education. R. Mehvar.
Chapman Univ.
11:00 Active Learning Exercises in Pharmacokinetics Using
Simulations and Other Resources. D. Brocks, R.
Mehvar. Univ. of Alberta and Chapman Univ.
Microbiome
9:30
Pharmacometabolomics Enabling Tools for Systems
Pharmacology and Precision Medicine. R. KaddurahDaouk. Duke Univ. Med. Ctr.
10:00 Pharmacometabolomics Informs and Compliments
Pharmacogenomics. R. Weinshilboum. Mayo Clin.
10:30 Gut Microbiome and Host Metabolic Interactions –
Implications for Drug Metabolism and Drug-Induced
Toxicity. W. Jia. Univ. of Hawaii Cancer Ctr.
11:00 Integrating Multiple Omics Reveals Novel Signatures
Associated with Thiazide Diuretics Blood Pressure
Response. M. Shahin. Univ. of Florida.
11:20 Stable Isotope Resolved Metabolomics on Fresh Human
Tissues as a Preclinical Drug Testing Platform. A.N.
Lane. Univ. of Kentucky.
11:50 Question and Answer Period.
316. BEYOND TRADITIONAL ASSESSMENTS OF
PAIN: IMPLICATIONS FOR DRUG DISCOVERY
OF NOVEL PAIN THERAPEUTICS
Symposium
Behavioral Pharmacology)
and Drug Discovery and Development )
Cochaired: C.A. Paronis and H. Neelakantan
Behavioral Pharmacology
Neurobiology
9:30 Analgesic Medication Development: Finding the
Appropriate Assay to Identify New Therapeutics.
R.P. Yezierski. Univ. of Florida.
10:00 Novel Methods of Assessing Nociception and
Antinocieption in Nonhuman Primates. B. Kangas.
Harvard Med. Sch., McLean Hosp.
10:30 Pharmacological Responses in Spontaneous Pain.
J. Mogil. McGill Univ.
11:00 Depression of Home Cage Wheel Running: A Novel
Method to Assess Spontaneous Migraine Pain.
R. Kandasamy, J.J. Calsbeek, M.M. Morgan.
Washington State Univ. (928.4)
11:15 Distinguishing Nonopioid Mediators of Pain Responses.
A. Hohmann. Indiana Univ.
95
M
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PHARMACOLOGYMONDAY
11:45 Neuropathic Pain Unmasks Delta Opioid ReceptorMediated Analgesia. E.W. Ong, S.V. Holdridge,
K.A. Sutherland, S.A. Armstrong, A.M.W. Taylor,
L. Xue, C.M. Cahill. Queen’s Univ., Canada, Univ. of
California, Irvine and UCLA. (928.1)
319. DIVERSITY 3.0: FROM FAIRNESS
TO EXCELLENCE
Lecture
(Sponsored by: The ASPET Mentoring and Career
317. BERNARD B. BRODIE AWARD IN DRUG
METABOLISM LECTURE
Education
Award Lecture
Career Development
Drug Metabolism
The Bernard B. Brodie Award in Drug Metabolism has been
established to honor the fundamental contributions of Bernard B.
Brodie in the field of drug metabolism and disposition. The Award
is presented biennially to recognize outstanding original research
contributions in drug metabolism and disposition, particularly
those having a major impact on future research in the field.
2:00Introduction.
2:05 Phenobarbital Induction of Drug Metabolism and
Beyond. M. Negishi. NIEHS, NIH.
This talk will describe the needed evolution from thinking
about diversity as competing with excellence to being a core
driver and marker of excellence. Through vivid narrative and
illustrative examples from other industries, be prepared and open
to a new vision on how we harness diversity and its necessary
inclusion to advance our profession. Participants from all EB
disciplines are welcome.
2:00
320. NOVEL PLATELET THERAPIES: ATTACKING
THEM FROM THE INSIDE AND OUT
Symposium
318. P.B. DEWS LIFETIME ACHIEVEMENT
AWARD FOR RESEARCH IN BEHAVIORAL
PHARMACOLOGY LECTURE
(Sponsored by: The Division for Cardiovascular Pharmacology)
(Cosponsored by: The Division for Translational and
Award Lecture
3:00 pm—San Diego Convention Center, Room 16AB
Behavioral Pharmacology)
Chaired: M. Nieman
The ASPET Division for Behavioral Pharmacology sponsors
the P. B. Dews Award for Research in Behavioral Pharmacology
to recognize outstanding lifetime achievements in research,
teaching, and professional service in the field of behavioral
pharmacology and to honor Dr. Peter Dews for his seminal
contributions to the development of behavioral pharmacology as
a discipline.
2:00Introduction.
2:05
Behavioral Mechanisms of Drug Action: Peter Dews’s
Legacy. T. Thompson. Univ. of Minnesota.
EB 2016?
96
Diversity 3.0: From Fairness to Excellence. M.A. Nivet.
Assn. of Amer. Med. Cols.
3:00
The Neighborhood Matters: How Interactions Within
the Membrane Influence Therapeutic Response.
M. Nieman. Case Western Reserve Univ.
3:30 Characterization of Function Blocking Antibodies
Targeting Platelets. Z. Karim. Western Univ. of
Hlth. Scis.
4:00
Targeting G-protein Coupled Receptors from the Inside
with Small Molecules. R. Flaumenhaft. Beth Israel
Deaconess Med. Ctr.
4:30 Platelet-Inspired Synthetic Hemostats: Mimicking
Platelet Functions on Engineered Biomaterial
Systems to Treat Bleeding. A.S. Gupta. Case
Western Reserve Univ.
5:00
Nanogel Drug Carriers Presenting Platelet GPIbα Mimic
and Enhance Platelet Adhesion. J.W. Myerson, I.
Johnston, J. Wu, R. McClintock, Z. Ruggeri, M.
Poncz, V. Muzykantov. Univ. of Pennsylvania and
The Scripps Res. Inst. (943.2)
5:15 Loss of Serotonin Transporter Function Alters ADPMediated αIIbβ3 Activation through Disregulation
of 5HT2A Receptor. K.H. Oliver, H. Hamm, A.M.D.
Carneiro. Vanderbilt Univ. (943.10)
MONDAYPHARMACOLOGY
321. DIVISION FOR BEHAVIORAL PHARMACOLOGY
SYMPOSIUM: QUANTITATIVE
PHARMACOLOGICAL ANALYSIS OF IN
VIVO DATA AND ITS IMPLICATIONS IN CNS
DRUG DISCOVERY
3:45
4:00
Division Symposium
(Sponsored by: The Division for Behavioral Pharmacology)
Cochaired: J-X. Li and L. Gerak
3:00 Understanding the Actions of GABAA Receptor
Modulators In Vivo Using Schild Analyses in Rhesus
Monkeys. L. Gerak. Univ. of Texas Hlth. Sci. Ctr. at
San Antonio.
3:30
Comparison of Heroin- and Δ9-TetrahydrocannabinolInduced Antinociception and Physical Dependence
in Monkeys. H. Ding, N. Kiguchi, S. Kishioka, M-C.
Ko. Wake Forest Sch. of Med. and Wakayama Med.
Univ., Japan. (703.5)
4:00
Combining Imidazoline I2 Receptor Ligands and Opioids
for Pain Management: A Composite Additive Curve
Analysis. J. Li. Univ. at Buffalo.
4:30
Predicting Additivity: Abuse-Related Effects of “BathSalt” Mixtures. G. Collins. South Texas Veterans
Hlth. Care Syst. - Audie L. Murphy VA Hosp.
5:00
PK/PD Modeling of Opioid Modulation: Application in the
Development of a Novel Treatment for Depression.
R. Turncliff. Alkermes, Inc.
4:15
4:30
5:00
323. DIVISION FOR MOLECULAR PHARMACOLOGY
POSTDOCTORAL SCIENTIST
AWARD FINALISTS
Division Oral Session
3:00
322. DIVISION FOR DRUG METABOLISM JAMES
GILLETTE AWARD AND PLATFORM SESSION
3:30
Cochaired: E.E. Scott and T.J. Carlson
4:00
Drug Metabolism
3:00 Predicting Fetal Exposure to Drugs throughout
Pregnancy Using a PBPK Model. Z. Zhang, M.Z.
Imperial, G.I. Patilea-Vrana, J. Wedagedera, G. Lu,
J.D. Unadkat. Univ. of Washington and Simcyp Ltd (a
Certara Co.), Sheffield, U.K. (712.6)
3:15
Implications of In Vitro System Conditions for CYP2C9
and CYP3A4: Impact of pH on Clearance and
Enzyme Inhibition. L.R.A. Rougee, M.A. Mohutsky,
D.W. Bedwell, K.J. Ruterbories, S.D. Hall. Eli Lilly
and Co. (934.8)
3:30
Effect of Ethanol on the Metabolism of Antiretroviral
Drugs Elvitegravir and Darunavir in the Presence
and Absence of Their Pharmacoenhancers in
Microsomes. N.M. Midde, M.A. Rahman, C. Rathi, J.
Li, B. Meibohm, W. Li, S. Kumar. Univ. of Tennessee
Hlth. Sci. Ctr., Memphis and East China Univ. of Sci.
and Technol., Shanghai. (934.4)
SULT4A1 Deletion in Zebrafish Alters Expression of
Genes Implicated in Neurological Disorders. P.L.
Garcia, F.L. Crittenden, C.N. Falany. Univ. of
Alabama at Birmingham. (1196.4)
Induction of CYP2A6 by Metronidazole in Primary
Human Hepatocytes. S. Stancil, C. Vyhlidal, G.
Kearns, S. Leeder, R.E. Pearce. Children’s Mercy
Hosp. and Univ. of Missouri-Kansas City and Arkansas
Children’s Hosp. Res. Inst., Little Rock. (934.9)
Endogenous Substrates for Tumor-Specific Human
Cytochrome P450 CYP2W1. Y. Zhao, P. Ortiz de
Montellano. UCSF. (934.7)
Dose of Phenobarbital and Age of Treatment at Early
Life are Two Key Factors for the Persistent Induction
of Cytochrome P450 Enzymes in Adult Mouse Liver.
Y. Chen Tien. Univ. of Connecticut Sch. of Pharm.
Modulation of P-Glycoprotein at the Human BloodBrain Barrier by Quinidine or Rifampin Treatment: A
Positron Emission Tomography Imaging Study. L. Liu.
Merck, Inc.
4:30
β-Adrenergic Receptors Regulate Innate Immune
Responses through β-Arrestin Dependent Pathways.
L.A. Grisanti, J. Gorsky, A.A. Repas, E. Gao, R.L.
Carter, J.E. Rabinowitz, J.L. Benovic, W.J. Koch,
D.G. Tilley. Temple Univ. Sch. of Med. (1202.6)
Structural and Functional Characterization of the
Metastatic RhoGEF P-Rex1 and Its Regulation by
PtdIns(3,4,5)P3: Towards Inhibitory Small Molecule
Development. J.N. Cash, E.M. Davis, J.J.G. Tesmer.
Univ. of Michigan. (1190.5)
Structurally Diverse Positive Allosteric Modulators of
the D1 Dopamine Receptor Potentiate G-Protein and
β-Arrestin-Mediated Signaling. K.D. Luderman, J.L.
Conroy, R.B. Free, N.T. Southall, M. Ferrer, J. Aubé,
K.J. Frankowski, D.R. Sibley. NINDS, NIH, NCATS,
NIH, Rockville and Univ. of North Carolina at Chapel
Hill. (931.9)
Keynote Speaker. Signaling by G Proteins and
Phospholipase C: Yes it’s still exciting!! A.V. Smrcka.
Univ. of Rochester Sch. of Med. and Dentistry.
97
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PHARMACOLOGYMONDAY
324. DIVISION FOR TRANSLATIONAL AND CLINICAL
PHARMACOLOGY: YOUNG INVESTIGATOR
AWARDS PLATFORM SESSION
Chaired: B.T. Green
3:00Introduction. B.T. Green. USDA, ARS.
3:15
Immunogenetic Role of G Protein Signaling Modulator 3
in the Pathogenesis of Rheumatoid Arthritis. B.J. Gall,
A.B. Schroer, J.D. Gross, P. Stoilov, V. Setola, C.M.
Watkins, D.P. Siderovski. West Virginia Univ. Hlth.
Sci. Ctr., Sch. of Med. (1202.5)
3:35
Systems Pharmacology Approach to Identify Potential
Therapeutic Small-Molecules for Treatment of
Diabetic Peripheral Neuropathy. B.A. McGregor, J.A.
Porter, E.A. Feldman, J. Hur. Univ. of North Dakota
and Univ. of Michigan. (1270.1)
3:55 Doxorubicin Acutely Inhibits Lymph Flow in Rat
Mesenteric Lymph Vessels. A.J. Stolarz, T.W.
Fletcher, J.C. Marecki, M. Sarimollaoglu, E.
Galanzha, V. Zharov, S. Klimberg, N.J. Rusch. Univ.
of Arkansas for Med. Sci. (1201.2)
4:15
Preclinical Evaluation of Flt3 Ligand to Improve T Cell
Adaptive Immune Response during Sepsis. N.K. Patil,
J.K. Bohannon, L. Luan, Y. Guo, E.R. Sherwood.
Vanderbilt Univ. Med. Ctr. (1202.3)
4:35 Microbiota-Derived Metabolites Associated with
Metabolic Improvements after Gastric Bypass
Surgery and Their Effects on Intestinal Cells In Vitro.
M. Jennis, J.R. Mabus, C.R. Cavanaugh, G. Leo,
J. Lenhard, P.J. Hornby. Janssen, Spring House,
PA. (720.3)
4:55Awards.
325. DIVISION FOR TRANSLATIONAL AND
CLINICAL PHARMACOLOGY: EARLY CAREER
FACULTY SHOWCASE
5:30 Structure-Based Ligand Discovery for Nutrient
Transporters. A. Schlessinger. Icahn Sch. of Med. at
Mount Sinai. (LB486)
5:45
Novel Mechanisms Regulating Platelet and Pancreatic
Beta Cell Function in Type 2 Diabetes Mellitus.
J. Wisinski, A. Reuter, M. Kimple. Univ. of WisconsinMadison. (1270.7)
98
MONDAYPHYSIOLOGY
Physiology
328. CARL LUDWIG DISTINGUISHED LECTURESHIP
OF THE APS NEURAL CONTROL AND
AUTONOMIC REGULATION SECTION
Lecture
DIETARY INFLUENCES ON PHYSIOLOGICAL
CONTROL MECHANISMS — HOW MUCH, WHEN
AND WHAT
Neurobiology
Symposium
Hypertension
Ballroom 20A
Neurophysiology
Chaired: J. Anthony
Diet, Nutrition and Metabolism, and Development
10:30 Amino Acid Deprivation and Nutritional Stress.
T. Anthony. Rutgers, The State Univ. of New Jersey.
11:00 Cardiovascular, Renal and Metabolic Consequences
of High Salt Diets. A. McDonough. Keck Sch. of
Med., USC.
11:30 Metabolic Consequences of High Fructose Diet.
R. Johnson. Univ. of Colorado Denver.
12:00 Timing of Meals: When Is as Critical as What and How
Much. F. Turek. Northwestern Univ.
327. ACHIEVING MASTERY USING NONSTANDARDIZED ASSESSMENT METHODS
Featured Topic
Chaired: L. Golden
Education
8:00 Collaborative Testing Improves Performance on
Long Answer Questions, and Maintains LongTerm Retention of Course Material. K.L. Ritchie,
R. Rajakaruna, G. Newton. Univ. of Guelph,
Canada. (776.7)
8:20
Promoting Motivationally and Educationally Productive
Behaviors with Collaborative Testing. R.N. Cortright,
H. Lujan, L.A. Johnson, S.E. DiCarlo. East Carolina
Univ. and Wayne State Univ. (776.6)
8:40 Developing Online Guided Self-Assessments in
Cardiovascular Physiology for Medical School.
T.A. Pressley, J.C. Fowler. Texas Tech Univ. Hlth.
Sci. Ctr. (776.20)
9:00Discussion.
9:10 Undergraduate Collaborative Writing in STEM: How
Learning to Write Authentically in the Discipline Can
Promote Mastery. E.M. Waters, W.M. Schlegel.
Indiana Univ. Bloomington. (553.1)
9:30
In Final Examinations, Quality of Essay Plan Correlates
with the Essay Mark. P. Langton. Sch. of Physiol.,
Pharmacol. and Neurosci., Univ. of Bristol, U.K. (776.5)
9:50Discussion.
Neurogenic Hypertension and the Secrets of Respiration.
B. Machado. Sch. of Med. Ribeirao Preto-USP, Brazil.
328A. RESPIRATORY-SYMPATHETIC COUPLING IN
CARDIOVASCULAR DYSFUNCTIONS
Minisymposium
Chaired: B.H. Machado
9:00 Are C1 Neurons Involved in the Sympathetic
Overactivity Induced by Chronic Intermittent Hypoxia?
D.J.A. Moraes, L.G.H. Bonagamba, J.F.R. Paton,
B.H. Machado. Sch. of Med. of Ribeirão Preto, Univ.
of São Paulo and Sch. of Physiol. and Pharmacol.,
Univ. of Bristol, U.K. (1006.9)
9:15 Increased Respiratory-Sympathetic Coupling via
C1 Neurons Contributes to the Development of
Hypertension in the Spontaneously Hypertensive Rat.
C. Menuet, N. Jancovski, J.K. Bassi, A.A. Connelly,
A.M. Allen. The Univ. of Melbourne (1006.8)
9:30 Enhanced Carotid Body Chemoreflex Function Drives
Respiratorysympathetic Coupling in Systolic Heart
Failure. R. Del Rio, N.J. Marcus, H.D. Schultz. Univ.
Autónoma de Chile, Santiago, Des Moines Univ. and
Univ. of Nebraska Med. Ctr. (LB725)
9:45 Active expiration and sympathetic excitation during
hypercapnia require glutamatergic neurotransmission
in the retrotrapezoid nucleus. E.V. Lemes and D.B.
Zoccal. Department of Physiology and Pathology,
Sch. of Dent. of Araraquara, São Paulo State Univ.,
Araraquara, SP, Brazil. (757.7)
99
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PHYSIOLOGYMONDAY
329. CEREBROVASCULAR DYSFUNCTION AND
REACTIVE NITROGEN SPECIES
Featured Topic
330. COOPERATION BETWEEN
ADAPTIVE AND INNATE IMMUNITY IN
CARDIOVASCULAR DISEASE
Featured Topic
Chaired: P. Katakam and J. Pollock
Chaired: K. DeLeon-Pennell and L. de Castro Bras
Oxidative Stress
Neurobiology
Neurophysiology
8:00
8:30
9:00
9:15
9:30
9:45
Role of Peroxynitrite in Vasoconstriction of Brain
Parenchymal
Arterioles
during
Postischemic
Reperfusion. M. Cipolla. Univ. of Vermont.
Peroxynitrite-Mediated Impairment of Cerebrovascular
Function and Neovascularization in Diabetes.
A. Ergul. Medical Col. of Georgia.
Critical Role of Telomerase in Regulating Cerebral
Vascular Function and Redox Environment. K. AitAissa, J. Hockenberry, D.D. Gutterman, A. Geurts,
A.M. Beyer. Med. Col. of Wisconsin. (953.5)
Role of Cerebrovascular Endothelial Dysfunction and
Oxidative/Nitrative Stress in Impaired Functional
Hyperemia: Implications for Age-Related Vascular
Cognitive Impairment. S. Tarantini, P.J. Toth, A.
Davila, M.N. Valcarcel-Ares, Z. Tucsek, B. Varamini,
P. Ballabh, W.E. Sonntag, J.A. Baur, A. Csiszar, Z.
Ungvari. Univ. of Oklahoma Hlth. Sci. Ctr., Univ. of
Pecs, Hungary, Univ. of Pennsylvania, Biola Univ. and
New York Med. Col. (953.1)
Impaired Myogenic Response of MCA Elevates
Transmission of Pressure to Penetrating Arterioles
and Contributes to Cerebral Vascular Disease in Aging
Hypertensive FHH Rats. F. Fan, M. Pabbidi, R.C.S.
Lin, Y. Ge, E.P. Gomez-Sanchez, G.K. Rajkowska,
M. Moulana, E. Gonzalez-fernandez, J. Sims, M.R.
Elliott, I.A. Paul, A.P. Alexander, T.H. Mosley, D.R.
Harder, R.J. Roman. Univ. of Mississippi Med. Ctr.
and Med. Col. of Wisconsin. (953.7)
Novel Splice Variant of nNOS in Cerebrovascular
Endothelial Cells Contributes to Superoxide and
Peroxynitrite Generation. V.N. Sure, I. Merdzo,
V.M. Abraham, N.P. Jain, G. Unis, T.P. Baker, N.R.
Peterson, A.O. Gordon, A.L. Chen, I. Rutkai, D.W.
Busija, P.V.G. Katakam. Tulane Univ. Sch. of Med.
(953.3)
8:00
8:15
8:30
9:00
9:15
9:45
331. HYPERTENSION: DEVELOPING CONCEPTS
Featured Topic
Chaired: P. O’Connor and D. Ho
8:00
8:30
8:45
100
Inhibition of Neutrophil Chemotaxis by N-AcetylSeryl-Aspartyl-Lysyl-Proline and Thymosin β4.
P. Nakagawa, J. Xu, G. Bordcoch, B. Janic, O.A.
Carretero. Henry Ford Hosp. (1207.5)
T Cell Deletion of Serum and Glucocorticoid-Regulated
Kinase 1 Attenuates Hypertension and End-Organ
Inflammation. A.E. Norlander, M. Saleh, A. Pandey,
H. Itani, J. Wu, B. Dale, D.G. Harrison, M. Madhur.
Vanderbilt Univ. (1216.6)
Role of Lymphocytes after Myocardial infarction.
S. Frantz. Univ. Hosp. Wurzburg, Germany.
Non-resolving Chemokine Response Dysregulates
Cardiosplenic and Cardiorenal Network following
Myocardial Infarction in Aging. G.V. Halade, V. Kain,
K. Ingle, L.M. Black. Univ. of Alabama at Birmingham.
(1208.1)
Regulation of the Inflammatory Response in Cardiac
Repair. N. Frangogiannis. Albert Einstein Coll.
of Medicine.
Activated Immune Cells Exacerbate Angiotensin IIInduced Hypertension and Renal Damage in the Dahl
Salt-Sensitive Rat. B.M. Wade, D. Mattson. Med. Col.
of Wisconsin. (964.3)
The Role of Renal Pericytes in the Physiological and
Pathophysiological Regulation of Medullary Blood
Flow. C. Peppiatt-Wildman. Medway Sch. of
Pharmacy, Univ. of Kent and Greenwich.
RhoBTB1, a Novel PPARγ Target Gene Regulates
Vascular Function. M. Mukohda, S-R.C. Ibeawuchi,
C. Hu, F.W. Quelle, C.D. Sigmund. Univ. of Iowa and
California Inst. for Biomed. Res., La Jolla. (964.14)
ACE2 Deletion Is Associated with Increased ADAM17
and Reduced Inhibitory Currents to Pre-sympathetic
Hypothalamic Neurons. S. Mukerjee, J. Xu, S.
Sriramula, H. Gao, A. Zsombok, E. Lazartigues.
LSU Hlth. Sci. Ctr., New Orleans and Tulane Univ.
(964.16)
MONDAYPHYSIOLOGY
9:00 Leptin-Mediated Increases in Sympathetic Tone
Decreases
Alpha(1D)-Adrenergic
Receptor
Expression in Arteries and Adrenals. M. Newell, M.
Momtahan, S. Kennard, E.J. Belin de Chantemele
Med. Col. of Georgia at Augusta Univ. (964.15)
9:15 Endothelial-Derived ET-1 Contributes to the Pressor
Response Elicited by Acute Behavioral Stress.
B.M. Fox, A.S. Loria, K.A. Hyndman, R. Johns,
C. Jin, D.M. Pollock, M. Yanagisawa, J.S. Pollock.
Univ. of Alabama at Birmingham, Univ. of Kentucky,
Georgia Regents Univ. and Univ. of Tsukuba, Japan.
(964.10)
9:30
The Role of Gαi2 Proteins in the Regulation of PVN
Neuronal Activation in Response to Isotonic Volume
Expansion in Conscious Rats. C.Y. Carmichael, N.M.
Patel, R.E. Wipfler, R.D. Wainford. Boston Univ. Sch.
of Med. (964.13)
9:45 Hemodynamic Mechanisms of Renal Injury in Dahl
SS Rats Fed a High Salt Diet. A. Polichnowski,
K. Griffin, P. Sethupathi, M. Picken, J. Long, G.
Williamson, A. Bidani. Hines VA Hosp. and Loyola
Univ.-Chicago and Illinois Inst. of Technol. (964.7)
332. INNATE IMMUNE FUNCTIONS OF
EPITHELIAL CELLS
Featured Topic
(Sponsored by: APS Gastrointestinal and Liver
Physiology Section)
Chaired: M. Frey
8:00
8:30
8:45
9:00
9:15
9:30
9:45
Paneth Cells as Mediators of Homeostasis in the Small
intestine. C. Bevins. Univ. of California, Davis Sch.
of Med.
Loss of PTPN2 in Intestinal Epithelial Cells Upregulates
a Novel STAT-Dependent Mechanism of Claudin-2
Expression. M. Krishnan, D.F. McCole. Univ. of
California, Riverside. (1017.1)
ErbB3 Negatively Regulates Homeostatic Paneth Cell
Numbers. D. Almohazey, J.J. Hsieh, C.V. Vossler,
M.R. Frey. Children’s Hosp. Los Angeles, Univ. of So.
California. (1017.2)
Stressor-Enhanced Infectious Colitis Is Due to Aberrant
Colonic Epithelial Cell Signaling. A. Mackos, M.T.
Bailey. Nationwide Children’s Hosp. Res. Inst. and
The Ohio State Univ. (1017.3)
Intestinal Mucus Acts Is a Maturation Factor for Dendritic
Cells. M.A. Engevik, R.S. Fultz, B.P. Ganesh, J.
Versalovic. Baylor Col. of Med. (1017.4)
The Effect of JAK-Inhibitor Tofacitinib on Intestinal
Epithelial Barrier Function. A. Sayoc, M. Krishnan,
D.F. McCole. Univ. of California, Riverside. (1017.5)
Intestinal Epithelial IL-15 Overexpression Enhances γδ
T Cell Mucosal Surveillance. K.L. Edelblum, B. Jabri,
J.R. Turner. Rutgers New Jersey Med. Sch. and Univ.
of Chicago. (1017.6)
333. METABOLIC CONSEQUENCES OF EXERCISE
Featured Topic
Metabolism Section)
Chaired: J. Steiner and G.L.C. Yosten
Diabetes, Metabolic Syndrome
8:00
Exercise Potentiates Metabolic Adaptations through
Autophagy Activation. A. Vainshtein. York Univ.
8:30 Impact of Specific Exercise Training Programs on
Muscle Mitochondrial Biology in Aging and in Insulin
Resistant States. K. Sreekumaran Nair. Mayo Clin.
9:00HIF-1α Regulates a Single Bout of Exercise-Induced
Hepatic Expression of Glucose and Lipid Metabolism
Related Genes. B. Luo, D. Xiang, P. Chen, Y. Hu
Second Military Med. Univ., Shanghai, Shanghai
Univ. of Sport and Naval Med. Res. Inst., Shanghai.
(1014.1)
9:15 Exercise Mitigates Cognitive Functions through
Mitochondrial Remodeling in Type-2 Diabetes.
A. Kalani, P. Chaturvedi, L.J. Winchester, S.C.
Tyagi, N. Tyagi. Univ. of Louisville. (1014.2)
9:30 Roux-en-Y Gastric Bypass Surgery Enhances
Contraction-Mediated Glucose Metabolism in Primary
Human Myotubes. J.M. Hinkley, K. Zou, S. Park, K.
Turner, D. Zheng, J.A. Houmard. East Carolina Univ.
(1014.3)
9:45 Defective Autophagy Causes a Maladaptive Cardiac
Phenotype to Exercise That Leads to Premature Death
and FGF21-Mediated Protection against Obesity and
Insulin Resistance. V.A. Lira, A. Kronemberger,
J.A. Call, H.M. Caster, R.O. Pereira, R.C. Laker, M.
Zhang, Z. Yan. Carver Col. of Med., Univ. of Iowa,
Univ. of Georgia and Univ. of Virginia. (1014.4)
334. MODULATORY INFLUENCE OF EXERCISE ON
PHYSIOLOGICAL FUNCTION WITH AGING
Symposium
Physiology Section)
Chaired: D.R. Seals and F. Booth
Sex Differences
8:00
Exercise, Physical Function and Mobility with Aging.
R. Fielding. USDA at Tufts Univ.
8:30 Effects of Exercise and Gonadal Aging on Body
Composition and Bone Density. W. Kohrt. Univ. of
Colorado, Denver Anschutz Med. Campus.
9:00
Exercise, Oxidative Stress, Inflammation and Vascular
Aging. D. Seals. Univ. of Colorado, Boulder.
9:30 Exercise, Functional Connectivity and Cognitive
Performance with Aging. M. Voss. Univ. of Iowa.
101
M
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PHYSIOLOGYMONDAY
335. NOVEL INSIGHTS IN VASCULAR DISEASE IN
METABOLIC SYNDROME
Symposium
8:15
8:30
Chaired: D. Weber and D. Stepp
8:45
8:00
8:30
9:00
9:30
Improving Vascular Health in Obesity: Can We Bottle
Exercise? D. Stepp. Georgia Regents Univ.
Deregulated Apoptosis and Proliferation are Key
Components of Impaired Coronary Collateral Growth
in the Metabolic Syndrome. P. Rocic. New York
Med. Col.
Role of Perivascular Adipose Tissue in the Progression
of Coronary Vascular Dysfunction and Disease.
J. Tune. Indiana Univ.
Vascular Smooth Muscle Phenotype Plays A Critical
Role in Abnormal Coronary Artery Remodeling in
Metabolic Syndrome. S. Gupte. New York Med. Col.
9:00
9:15
9:30
336. PUBLISHING 101: HOW TO GET YOUR WORK
PUBLISHED AND AVOID ETHICAL MINEFIELDS
Symposium
9:45
(Sponsored by: APS Publications Committee)
Chaired: C.D. Sigmund and R. Scheman
Career Development
338. AVIAN OSMOREGULATION: UNIQUE
SOLUTIONS, UNANSWERED QUESTIONS
8:00
Choosing A Journal, Authorship and Peer Review.
C. Sigmund. Univ. of Iowa.
8:30
Ethical Minefields I: Plagiarism and Data Duplication.
K. Barrett. UCSD.
9:00 Ethical
Minefields
Ii:
Image
Manipulation.
C. Bennett. APS.
9:30
Meet the Editors Panel. B. Joe, N. Bunnett. Univ. of
Toledo Col. of Med., Monash Inst. of Pharmaceut. Sci.
Featured Topic
Physiology Section)
Chaired: K. Sweazea and D. Goldstein
Ion Transport
337. SEX DIFFERENCES IN HEALTH AND DISEASE
Featured Topic
(Sponsored by: APS Trainee Advisory Committee)
Ballroom 20A
Chaired: D. Ilatovskaya and C. Banek
Sex Differences
8:00 Differential
Effects
of
Menopausal
Hormone
Formulations on Plasma Orexin A Levels in Women
of the Kronos Early Estrogen Prevention Study.
D. Cintron, J. Beckman, J. Muthuvel, V. Miller. Mayo
Clin., Univ. of Puerto Rico-Med. Sci. Campus, San
Juan and St. Olaf Col., MN. (1248.1)
102
Thyroid Hormone Deficiency Disrupts Respiratory
Control Development and Responses to Hypoxia
in Newborn Rat. J-P. Rousseau, R. Kinkead. Univ.
Laval, Québec. (773.9)
Sympathetic Vasoconstriction Is Attenuated in Young
Women during Hypoxia and Cold Pressor Test.
A.J. Ross, M.D. Muller, J.C. Luck, J. Cui, L.I.
Sinoway. Hershey Heart and Vasc. Inst., Penn State
Col. of Med. (1001.2)
Pericytes Improve Motor Recovery after Spinal Cord
Injury in Both Sexes. J.N. Mayo, S.E. Bearden. Univ.
of Melbourne and Idaho State Univ. (1210.3)
Heightened Anaphylaxis Reaction in Female Mice Is
Associated with Increased Synthesis of Mast Cell
Secretory Granule-Associated Immune Mediators.
E. Mackey, S. D’Costa, C. Pohl, S. Ayyadurai, S.
Laster, A.J. Moeser. North Carolina State Univ., GI
Stress Biol. Lab., East Lansing, Univ. of North Carolina
at Chapel Hill and Michigan State Univ. (1023.1)
Estradiol Facilitates a More Rapid Natriuretic Response
to a High Salt Diet in Female Rats. E.Y. Gohar, D.M.
Sexual Dimorphic Expression of Renal Claudins,
Water Channels and Transporters Accounts for the
Downstream Shift in Salt and Volume Reabsorption
Along the Nephron in Female versus Male Rats.
L.C. Veiras, L. Pei, A.S.L. Yu, A.A. McDonough.
Keck Sch. of Med., Univ. of So. California and Univ. of
Kansas Med. Ctr. (967.29)
Mitochondria-eNOS-Estrogen Axis Provides Pathway to
Protection against Stroke. I. Rutkai, S.V. Wunnava,
I. Merdzo, P.V. Katakam, D.W. Busija. Tulane Univ.
(953.9)
10:30
The Past, Present, and Future of Avian Osmoregulation
Research. E. Braun. Univ. of Arizona.
11:00 Countercurrent Urine Concentration and Role of
Aquaporins in Avian Kidneys. H. Nishimura. Univ. of
Tennessee, Memphis.
11:30 The Integration of Gastrointestinal and Renal Function
in Nectar-Feeding Birds. T.J. McWhorter. Sch. of
Animal & Vet. Sci., Univ. of Adelaide. (976.3)
11:45 Avian Osmoregulation in Flight: Unique Metabolic
Adaptations Present Novel Challenges. A.R. Gerson,
C. Guglielmo. Univ. of Massachusetts Amherst and
Univ. of Western Ontario. (976.1)
12:00 Water Balance in Desert Birds – Challenges in a Rapidly
Warming Environment. B.O. Wolf. Univ. of New
Mexico. (976.4)
MONDAYPHYSIOLOGY
12:15 Preliminary Examination of a Role for Insulin in the
Regulation of Glucose Excretion in Mourning Doves
(Zenaida macroura). K.L. Sweazea, E.J. Braun.
Arizona State Univ. and Univ. of Arizona. (976.2)
339. CELL SIGNALING: PROTEINS, PATHWAYS,
AND MECHANISMS
Featured Topic
Chaired: C. Waters
Featured Topic
Physiology Section)
Chaired: M. Rao
10:30
340. ENVIRONMENTAL EXPOSURES, OXIDATIVE
STRESS, AND LUNG DISEASE
Loss of the Inhibitory G-Protein, Gz, Protects against
Type I Diabetes-Like Hyperglycemia by Stimulating
Islet Signaling Pathways That Promote Beta-Cell
Function and Survival. R.J. Fenske, M.T. Cadena,
A.L. Brill, N.A. Truchan, M.E. Kimple. Univ. of
Wisconsin-Madison and William S. Middleton Mem.
Veterans Hosp. (969.28)
10:45 Chenodeoxycholic Acid Initiates Distinct Signaling
Mechanisms to Stimulate Cl- Transport in Intestinal
and Non-intestinal Epithelial Cells. J. Domingue, A.
George, M. Ao, M. Bijvelds, H. de Jonge, J. Sarathy,
M.C. Rao. Univ. of Illinois at Chicago, Erasmus MC,
Rotterdam and Benedictine Univ., IL. (969.25)
11:00 Enhancement of Neutrophil Antimicrobial Activity by the
Breast Cancer Drug Tamoxifen. R. Flores, P.A. Insel,
V. Nizet, R. Corriden. UCSD. (969.14)
11:15 Danger Signaling, IL-33 Secretion, and Allergic
inflammation following Airway Exposure to Fungal
Allergens. S. O’Grady. Univ. of Minnesota, St. Paul.
11:45A-Kinase Anchoring
Proteins
Coordinate
the
Contractile Phenotype of Airway Smooth Muscle.
W.J. Poppinga, B. Han, C.R. Elzinga, A.J. Halayko,
H. Meurs, M. Schmidt. Univ. of Groningen and
Univ. Med. Ctr. Groningen, Netherlands and Univ. of
Manitoba. (969.29)
12:00 Mutation in the PPARγ Ligand Binding Domain Impairs
the AntiiInflammatory Action of PPARγ. M. Mukohda,
P. Ketsawatsomkron, M. Stump, X. Liu, D.F. Guo, K.
Rahmouni, F.W. Quelle, C.D. Sigmund. Univ. of Iowa
and Nortis Inc., Seattle. (969.12)
12:15 N-Cadherin Adhesion Modulates RhoGTPase Signaling
to Promote Endothelial Barrier Integrity. K.J. Kruse,
F. Huang, S. Ying, S. Vogel, A. Malik, Y. Komarova.
Univ. of Illinois at Chicago. (969.33)
10:30 Molecular Mechanisms Linking Air Pollution and
Asthma Development in infants. S. Cormier. Univ. of
Tennessee Hlth. Sci. Ctr.
11:00 Protective Role of Ergothioneine from Tobacco SmokeInduced Oxidative Stress In Vitro and In Vivo.
C. Ehrhardt, M.A. Selo, C.G. Clerkin, B.N. Talbot,
J.J. Walsh, N. Nakamichi, Y. Kato, J.B. Lewis, P.R.
Reynolds, S. Nickel. Sch. of Pharm. and Pharmaceut.
Sci., Trinity Col. Dublin, Kufa Univ., Iraq, Kanazawa
Univ., Japan and Brigham Young Univ. (982.1)
11:15 Mechanisms Involved in the Antioxidant Properties
of Azithromycin in Lung Epithelial Cells Stimulated
with Cigarette Smoke Extract. S. Cuevas, Y. Yang,
I. Armando, P.A. Jose. George Washington Univ.
and Univ. of Texas, Galveston. (982.2)
11:30 Inter-strain Variation in Mouse Mitochondrial Genome
and Effects of Oxidative Stress. K.C. Verhein, A.
Burkholder, J.L. Nichols, Z. McCaw, J. Marzec, V.
Panduri, W. Gladwell, N. Reeves, J. Malphurs, G.
Solomon, T. Wiltshire, D. Fargo, D. Bell, B. Van
Houten, S.R. Kleeberger. NIEHS, NIH, Research
Triangle Park, Eschelman Sch. of Pharm., Univ.
of North Carolina at Chapel Hill and Univ. of
Pittsburgh. (982.3)
11:45Investigation
of
the
Cardiotonic
Steroids,
Marinobufagenin and Resibufogenin, in the Acute
Respiratory Distress Syndrome. M.M.K. Abbas,
Q. Chen, A. Das, J. Oliver, W. Jiang, B. Moorthy,
B. Patel, K. Morin, J. Puschett. Texas A&M Col. of
Vet. Med. and Biosci., Texas Children’s Hosp., Baylor
Col. of Med. and Univ. of Texas-Houston and Mem.Hermann Hosp., Houston. (982.4)
12:00 Alveolar Acid Injury Causes Endothelial Mitochondrial
Depolarization. R.F. Hough, G.A. Gusarova, M.N.
Islam, J. Bhattacharya. Columbia Univ. Med. Ctr.
(982.5)
12:15 Alterations in the Expression of Profilin1/pVASP-S157
and Cofilin1/pVASP-S239 in Perinatal Inflammation/
Neonatal Hyperoxia-Induced Lung Injury. M. Ali, K.M.
Heyob, L.K. Rogers. Nationwide Children’s Hosp.
and The Ohio State Univ. (982.6)
Visit the Exhibits
April 3–April 5
Exhibit Hours
103
M
O
N
PHYSIOLOGYMONDAY
341. EPITHELIAL PHYSIOLOGY AND TRANSPORT II
Featured Topic
343. HYDRATION PHYSIOLOGY: FROM CELLS TO
SYSTEMS AND CLINICAL HEALTH OUTCOMES
Symposium
Chaired: K. Hamilton and M. Helms
Ion Transport
Hypertension
10:30 Steven C. Hebert Lecture. Salt Transport in the
Kidney and Lung: Transport Pathways Designed by
Committee. D. Eaton. Emory Univ.
11:15 The Mineralocorticoid Receptor (MR) Regulates
ENaC but Not NCC in Mice with Random MR
Deletion. J. Czogalla, T. Vohra, D. Penton Ribas, M.
Kirschmann, M. Carrel, J. Loffing. Univ. of Zürich
and Swiss NCCR Kidney.CH, Zürich. (1223.1)
11:30 Ankyrin G Alters ENaC Membrane Delivery to Increase
Na+ Transport in the Distal Kidney Nephron.
C.A. Klemens, L. Kightlinger, X. Liu, R. Edinger,
M.B. Butterworth. Univ. of Pittsburgh. (1223.2)
11:45 Interleukin-6 Transactivation of the Mineralocorticoid
Receptor. B.M. Wynne, T.A. Kronk, O. Al-Khalili,
R. Mallick, B. Ko, D.C. Eaton, R.S. Hoover. Emory
Univ., Univ. of Chicago and Atlanta VA Med. Ctr.,
Decatur. (1223.3)
12:00ASIC1a/α-ENaC Hybrid Channels Contribute to Alveolar
Fluid Clearance. P. Trac, M.M. Greenlee, O. AlKhalili, D.C. Eaton. Emory Univ. (1223.4)
12:15 Regulation of ENaC by Specific Palmitoyltransferases.
A. Mukherjee, Z. Wong, P.A. Poland, N. Montalbetti,
M. Butterworth, M. Fukata, T.R. Kleyman, R.P.
Hughey. Univ. of Pittsburgh and Natl. Inst. for Physiol.
Sci., Okazaki, Japan. (1223.5)
342. EXERCISE AND CANCER: FROM
CARDIOVASCULAR OUTCOMES TO THE
TUMOR MICROENVIRONMENT
Symposium
Physiology Section)
Chaired: B.J. Behnke and L. Jones
Chaired: L.E. Armstrong
10:30 Cell Physiology and Water Balance. F. Lang. Univ.
of Tübingen.
10:55 Water, Vasopressin and the Kidney. L. Bankir. INSERM,
Chatillon, France.
11:20 Dehydration-Induced Renal Injury: A FructokinaseMediated Disease? M. Garcia. Univ. of Colorado
Denver, Anschutz Med. Campus.
11:45 Vasopressin from Regulator to Disease Predictor.
O. Melander. Lund Univ., Sweden.
12:10 Defining and Assessing Hydration through Relevant
Biomarkers. E. Perrier. Danone Nutricia Res.,
Palaiseau, France.
344. NEUROIMMUNE CROSSTALK IN THE GUT
Symposium
Physiology Section)
Chaired: B.D. Gulbransen and A.E. Lomax
Neurobiology
Microbiome
10:30 Modulation of the Intestinal Immune System by the
Nervous System. G. Boeckxstaens. Univ. Hosp.
Leuven, Catholic Univ. Leuven, Belgium.
11:00 Plasticity of the Autonomic Nervous System in Response
to Gastrointestinal inflammation. A. Lomax. Queen’s
Univ., Canada.
11:30 Neuro-Endocrine-Immune Pathways Contribute to
the Pathophysiology of Irritable Bowel Syndrome.
D. O’Malley. University Col. Cork.
12:00 The Role of Enteric Glial Cells as a Bridge between
Intestinal
Immune
and
Nervous
Systems.
B. Gulbransen. Michigan State Univ.
Cancer Biology
10:30
Accelerated Cardiovascular Disease in Cancer Patients
and the Cardioprotective Role of Exercise. J. Scott.
NASA Johnson Space Ctr.
11:00 Cancer as a Model of Accelerated Physiological Aging.
L. Jones. Mem. Sloan Kettering Cancer Ctr.
11:30 Tumor Vascular (Dys) Function and Hemodynamics
during Exercise. B. Behnke. Kansas State Univ.
12:00Exercise
Based
Modulation
of
the
Tumor
Microenvironment – Impact on Anticancer Therapies.
D. Siemann. Univ. of Florida Hlth. Cancer Ctr.
104
MONDAYPHYSIOLOGY
345. NOVEL MECHANISMS OF GENE REGULATION
IN THE KIDNEY
Symposium
348. EDWARD F. ADOLPH DISTINGUISHED
LECTURESHIP OF THE APS ENVIRONMENTAL
AND EXERCISE PHYSIOLOGY SECTION
Lecture
Oxidative Stress
Chaired: M. Gumz and R. Hoover
10:30
11:00
11:30
12:00
Circadian Clock Protein-Mediated Regulation of Renal
Sodium Transport. M. Gumz. Univ. of Florida.
Medullary Class1 Histone Deacetylase Enzymes and
Fluid-Electrolyte Balance. K. Hyndman. Univ. of
Alabama at Birmingham.
miRNA, Fibrosis and the Proximal Tubule. I. Armando.
George Washington Univ.
The Role of KLF15 as a Transcriptional Regulator of
Podocyte Differentiation. S. Mallipattu. Stony Brook
Univ. Sch. of Med.
346. SOLOMON A. BERSON DISTINGUISHED
LECTURE OF THE APS ENDOCRINOLOGY AND
METABOLISM SECTION
Lecture
Cellular Mechanisms of Insulin Resistance: Implications
for Obesity, Type 2 Diabetes, and the Metabolic
Syndrome. G. Shulman. HHMI, Yale Univ. Sch.
of Med.
347. THYROID HORMONE MODULATION OF
CARDIAC FUNCTION AND REMODELING:
BENCH TO BEDSIDE
Symposium
Chaired: M. Portman and A.M. Gerdes
10:30
Thyroid Hormone and Heart Failure. A. Gerdes. New
York Inst. of Technol.
11:00 Posttranslational Regulation of Thyroid Hormone
Receptors during Cardiac Hypertrophy and
Remodeling. M. Willis. Univ. of North Carolina.
11:30 Thyroid Hormone Regulation of Postnatal Cardiomyocyte
Proliferation. A. Husain. Emory Univ.
12:00 Triiodothyronine Supplementation Modulates Cardiac
Metabolism and Improves Clinical Outcomes
during Stress-Induced Sick Euthyroid Syndrome.
M. Portman. Seattle Children’s Hosp. and Univ.
of Washington.
Exercise: Teaching Myocytes New Tricks. S. Powers.
Univ. of Florida.
349. CARDIOPULMONARY EFFECTS OF
ENVIRONMENTAL STRESSORS
Featured Topic
Chaired: L. Wold
3:15 Deployment-Related Toxicants: Effects on the
Cardiopulmonary System. M. Falvo. VA New Jersey
Hlth. Care Syst.
3:45
Thermoregulatory and Ventilatory Responses in Humans
with a Patent Foramen Ovale during Passive Cooling
While Immersed in 20°C Water. J.T. Davis, M.W. Hay,
A.M. Hardin, A.T. Lovering. Univ. of Oregon. (954.9)
4:00 Influence of Acute Lower Limb Heating on Clinical
Measures and Functional Capacity in Peripheral
Artery Disease. T.K. Pellinger, C.B. Pearce, G.H.
Simmons. Salisbury Univ. and Univ. of MissouriColumbia Sch. of Med. (954.8)
4:15
Maternal Separation Stress Causes Mis-p[rogramming
of Arterial Smooth Muscle Maturation. J. Reho, S.A.
Fisher. Univ. of Maryland Sch. of Med. (954.4)
4:30
Exposure to PM2.5 during the First Trimester Contributes
to Adult Cardiac Dysfunction. V. Tanwar, M. Gorr, C.
Eichenseer, L. Wold. The Ohio State Univ. (954.7)
4:45 Endothelial Hyper-permeability and Cardiomyocyte
Dysfunction following Coronary Artery Bypass
Grafting. M. Velten, G.D. Duerr, M. Hamiko, S. Frede,
L.K. Rogers, G. Baumgarten, A. Hoeft, T. Hilbert.
Univ. Med. Ctr. Bonn and Nationwide Children’s
Hosp., Columbus, OH. (954.3)
5:00Wrap-Up. L. Wold. The Ohio State Univ.
350. CARL GOTTSCHALK DISTINGUISHED
LECTURESHIP OF THE APS RENAL SECTION
Lecture
Aldosterone and Hypertension: What’s the DCT Got to
Do with It? D. Ellison. Oregon Hlth. & Sci. Univ.
105
M
O
N
PHYSIOLOGYMONDAY
351. ENVIRONMENTAL REGULATORS
OF INFLAMMATION: GENETIC AND
EPIGENETIC IMPLICATIONS
Featured Topic
(Sponsored by: APS Physiological Genomics Group)
Chaired: K. Claycombe and S. Meydani
3:15Introduction. K. Claycombe. USDA, Grand Forks.
3:30
Epigenetic Regulation of Macrophage Polarization and
Renal Inflammation. S. Pushpakumar, L. Ren, R.
Biswas, U. Sen. Univ. of Louisville. (771.11)
3:45 Vitamin D Supplementation and DNA Methylation
Patterns during Pregnancy and Lactation in Mothers
and Infants. C.M. Anderson, D.K. Thiele, J.L. Ralph,
D. Perley, J.E. Ohm. Col. of Nursing, The Ohio State
Univ., Sch. of Nursing, Oregon Hlth. & Sci. Univ. and
Col. of Nursing and Prof. Disc. and Sch. of Med. and
Hlth. Sci., Univ. of North Dakota. (1028.3)
4:00
The Essence of Quiescence: Understanding the Roles
of Histone Modification H4K20me3 and the Histone
Modifying Enzyme Suv4-20h2 in Cellular Quiescence.
A.Z. Corvalan, A.G. Evertts, W.E. Lowry, H.A. Coller.
UCLA and Princeton Univ. (1028.5)
4:15 Histone Deacetylase Inhibitors Exhibit Enhanced
Kidney Functions in Guanylyl Cyclase-A/Natriuretic
Peptide Receptor-A Gene-Disrupted Mice: Role of
Epigenetic Mechanisms. P. Kumar, R. Periyasamy,
U. Subramanian, K.N. Pandey. Tulane Univ. Hlth.
Sci. Ctr. (771.2)
4:30
Searching for the Genetic Basis of Impaired Placentation
in the Dahl Salt Sensitive Rat Model of Superimposed
Preeclampsia. J.M. Sasser, A.C. Johnson, M.R.
Garrett. Univ of Mississippi Med. Ctr. (771.8)
4:45
RNA Next Gen Sequencing of Kidneys from Diabetic
Rats Provides Insights into Reno-protective Effects
of Vitamin D Receptor Activation. S.S. Prabhakar, K.
Kam, R. Kottapalli, C. Yego. Texas Tech Univ. Hlth.
Sci. Ctr. (771.3)
5:00
MicroRNAs Target Decidual Angiogenic Factors during
Early Pregnancy in BPH/5, a Spontaneous Mouse
Model of Preeclampsia. J. Xia, S. Baxter, J. Grenier,
R.L. Davisson, J.L. Sones. Cornell Univ. (1028.14)
352. INFLAMMATION AND ITS INFLUENCE ON LUNG
FUNCTION AND RESPIRATORY CONTROL
106
Lecture
Neurobiology
Neurophysiology
Symposium
(Sponsored by: APS Women in Physiology Committee)
Chaired: K.M. Mathis and K.L. Sweazea
Career Development
4:05
Intermittent Hypoxia-Dependent Regulation of Microglial
Activities and Respiratory Plasticity. J. Watters. Univ.
Ventilatory Acclimatization to Hypoxia Requires Early
Microglia Activation. J.A. Stokes, T.E. Arbogast, F.L.
Powell. UCSD. (1262.2)
Immune Stress and the Brain: Synaptic Substrates of
Sickness. Q. Pittman. Univ. of Calgary, Canada.
354. NEGOTIATING FOR SUCCESS!
3:15
3:45
Chaired: S.M. Wilson and C.G. Wilson
3:45
353. JOSEPH ERLANGER DISTINGUISHED
LECTURESHIP OF THE APS CENTRAL
NERVOUS SYSTEM SECTION
Featured Topic
3:15
4:00 Lipopolysaccharide-Induced IL-6 and TNF-Alpha
Expression in Neonatal Rat Nucleus Tractus Solitarii
In Vivo. R. Johnson, S. Murray, C. Wilson. Loma
Linda Univ. (1262.3)
4:15
The Src Family Tyrosine Kinase fyn Protects Mice from
Inflammation-Induced Lung Injury. Y.D. Jin, Y. Liu,
J.K. Trittmann, L.G. Chicoine, B. Chen, L.D. Nelin.
Nationwide Children’s Hosp. and The Ohio State
Univ. (1262.6)
4:30 Effects of Two-Hit Lipopolysaccharide Administration
on Basal Inspiratory Motor Activity in Spontaneously
Breathing Adult Male C57BL/6 Mice. R.M.Wadolowski,
M.S. Ahmad, M. Wang, I.C. Solomon. Stony Brook
Univ. (1262.10)
4:45 Differential Effects of Systemic versus Intratracheal
Lipopolysaccharide Administration on Inspiratory
Motor Output in Anesthetized Spontaneously
Breathing Sprague Dawley Rat. M. Wang, R.M.
Wadolowski, M.S. Ahmad, I.C. Solomon. Stony
Brook Univ. (1262.12)
5:00
Sensitizing Effects of Chronic Pretreatment with Tumor
Necrosis Factor Alpha on Vagal Pulmonary Afferent
Sensitivity in Mice. R-L. Lin, L-Y. Lee. Univ. of
Kentucky. (1262.13)
4:15
4:25
4:35
4:45
4:55
Making Your Personality Type Work for You.
Negotiation 101: Skills Everyone Needs. P. Blair.
Manpower, San Diego.
Negotiation 201: Industry Sales/Marketing. K. Atkinson.
Illumina, Inc.
Negotiation 201: Industry R&D. M. Alonso-Galicia.
Bayer Healthcare LLC, San Francisco.
Negotiation 201: Academia Research. K. Barrett. UCSD.
Negotiation 201: Academia Teaching. J. Uno. Elon Univ.
Negotiation 201: Military. K. Ryan. U.S. Army Inst. of
Surg. Res., TX.
Panel Discussion.
MONDAYPHYSIOLOGY
355. ROLE OF EPITHELIUM IN INNATE DEFENSE:
MORE THAN A BARRIER
Symposium
357. THE CONTROL OF SKELETAL MUSCLE
ATROPHY IN RESPONSE TO DISUSE: CLINICAL/
PRECLINICAL CONTENTIONS AND FALLACIES
OF EVIDENCE
Ballroom 20A
Symposium
Chaired: J.P. Garnett
Metabolism Section)
Chaired: P.J. Atherton and C. Lang
The Retinal Pigment Epithelial Cell: Key Role in Ocular
Innate Immunity. B. Detrick. Johns Hopkins Univ.
Sch. of Med.
3:55 Epithelial Innate Immune Pathways in Intestinal
Homeostasis. K. Maloy. Univ. of Oxford.
4:35 3D Lung Models for Studying Host-Pathogen
interactions and Antimicrobial Treatment Efficacy In
Vitro. A. Crabbe. Univ. of Ghent.
5:00
Panel Discussion.
3:15
356. SCIENTIFIC FOUNDATION FOR CLINICAL
PRACTICE: MORE THAN A PILE OF FACTS
Symposium
3:15
3:35
3:55
4:15
4:35
3:15
3:45
4:15
4:45
Is there a Role of insulin Resistance in Driving Muscle
Disuse Atrophy? P. Greenhaf. Univ. of Nottingham.
The Regulation of Protein Metabolism in Human Disuse
Atrophy: Now and the Future. S. Phillips. McMaster
Univ., Canada.
The Regulation of Protein Metabolism in Pre-Clinical
Models of Disuse Atrophy: Now and the Future.
S. Bodine. Univ. of California, Davis.
Insights into Atrophy Using Systems Approaches: Now
and the Future. C. Adams. Univ. of Iowa.
358. TRANSCRIPTIONAL AND EPIGENETIC
REGULATION OF CARDIORESPIRATORY HOMEOSTASIS
Chaired: M.L. Alacórn Fortepiani and P. Sanchez-Diaz
Symposium
Education
(Sponsored by: APS Hypoxia Group)
Application of Core Concepts in Physiology to
Student-Centered Learning and Scientific Teaching.
J. McFarland. Edmonds Community Col., WA.
Teaching Basic Sciences When Time is Tight: Blended
Learning, Just in Time Teaching, and In-Class Case
Discussion. P. Sanchez-Diaz. Rosenberg Sch. of
Optom., Univ. of the Incarnate Word, San Anotnio.
Building A Solid Pathophysiology Foundation for Clinical
Practice in Optometry. M. Lourdes Fortepiani.
Rosenberg Sch. of Optom., Univ. of the Incarnate
Word, San Anotnio.
Teaching Physiology in a Medical School. L. HarrisonBernard. LSU Hlth. Sci. Ctr. Sch. of Med.
Panel Discussion.
Chaired: G.L. Semenz and J-M. Ramirez
Oxidative Stress
Hypertension
Neurobiology
3:15
Regulation of Cell Metabolism by Hypoxia-Inducible
Factors. G. Semenza. Johns Hopkins Univ. Sch.
of Med.
3:45
Epigenetic Regulation of Redox State inder Intermittent
Hypoxia. J. Nanduri. Univ. of Chicago.
4:15 Transcriptional Mechanisms Underlying HypoxiaInduced Pulmonary Hypertension. L. Shimoda.
Johns Hopkins Univ. Sch. of Med.
4:45
Genetic Determinants of Red Blood Cell Production.
J. Prchal. Univ. of Utah.
107
M
O
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PHYSIOLOGYMONDAY
359. VAGAL-RESPIRATORY COUPLING AND ITS
IMPLICATIONS IN HEALTH AND DISEASE
360. ERLANGER LECTURE MINISYMPOSIUM
Minisymposium
Featured Topic
Regulation Section)
Chaired: Q.J. Pittman and S.S. Stocker
Neurobiology
Chaired: M. Dutschmann
Neurobiology
Neurophysiology
3:15
3:45
4:15
4:30
4:45
5:00
108
Origins of Cardiac Vagal Tone and Its Modulation by the
Respiratory Control Circuit. D. Farmer. Florey Inst.
Interaction of Vagal Bradycardia and Respiratory
Failure in Animal Models of Sudden Death in
Epilepsy. F. Kalume. Seattle Children’s Hosp. Univ.
of Washington.
Quantification of Cardiac Baroreflex Sensitivity during
Autonomic Stimulation. P. Sharma, M. Mavai, O.L.
Bhagat, M. Murugesh, S. Sircar. All India Inst. of
Med. Sci., Jodhpur. (1236.1)
Dynamics of Cardio-respiratory Coupling during Sighs
in Conscious Rats. E. Bondarenko, E. Nalivaiko.
Univ. of Newcastle, Australia. (1236.2)
Improvement of Vagal Tone and Reduction in the Blood
Pressure by Physical Training in Aging Spontaneously
Hypertensive Rats. L.O. Dellacqua, L.C. Michelini,
C. Hindmarch, J.F.R. Paton, D. Murphy, V. Antunes.
Univ. of São Paulo and Univ. of Bristol. (1236.3)
Protection of Renal Ischemia/reperfusion Injury by
Optogenetic Stimulation of the C1 Neurons. C. Abe, T.
Inoue, A. Inglis, K. Viar, L-P. Huang, H. Ye, D. Rosin,
R. Stornetta, M. Okusa, P. Guyenet. Univ. of Virginia.
(1236.4)
Neurophysiology
4:15
4:30
4:45
5:00
Neonatal Maternal Separation Increases Microglial
Activation in Brainstem Regions Controlling the
Laryngeal Chemoreflex. C. Baldy, S. BoisjolyVilleneuve, S. Fournier, M-E. Tremblay, R. Kinkead
CHU de Québec, Laval Univ. (991.2)
Dopamine System Regulation of Inhibition in an Animal
Model of Interneuron Transcriptional Dysregulation
and Hippocampal Circuit Dysfunction. L. Brady,
A. Bartley, Q. Li, L. Dobrunz. Univ. of Alabama at
Birmingham. (1284.7)
Inhibition of Endocannabinoid Degradation Improves
Recovery of Neurobehavioral Function and Resolution
of Neuroinflammation and Synaptic Hyperexcitability
in a Rodent Model of Traumatic Brain Injury.
J.P. Mayeux, P. Katz, S. Edwards, J. Middleton,
P. Molina. LSU Hlth. Sci. Ctr., New Orleans. (993.5)
Depletion of Brain Perivascular Macrophages Mitigates
Depressive-Like Behavioral Consequences of Chronic
Mild Stress. J-S. Grigoleit, E. Alvarez, C.B. Farrokhi,
P.E. Sawchenko. Salk Inst. for Biol. Studies. (991.8)
TUESDAY, APRIL 5
Across Societies
361. CAREER DEVELOPMENT WORKSHOPS
Workshop
Tue. 9:00 am—San Diego Convention Center, Exhibit Hall D
Career Development
Practice Lab
9:00
9:00 Understanding Search Committees & Finding
Job Announcements. A. Green. Univ. of
9:00
10:00 Navigating the Protocol, Milestones & Graduate Degree
Requirements. H. Adams. H.G. Adams & Assocs.
Inc., Norfolk, VA.
Practices: Mentoring, Collaboration, Peer Review,
Data Management and Ownership. S. Sodeke,
T. Turner. Tuskegee Univ., Jackson State Univ.
10:30 Talking About Yourself: How to Interview Well.
N. Saul. UCSF.
10:30
11:00
1:00
1:00
1:00
1:00
1:00
2:30
2:30
3:00
3:00
Ten Ways to Get Lucky in the Job Search. P. Clifford.
Univ. of Illinois at Chicago, Med. Col. of Wisconsin
and Marquette Univ.
Making Mistakes When Speaking: How to Handle Them.
Selling Yourself to the Life Sciences Industry. J. Tringali.
Tringali & Assocs. Inc.
Creating Effective CV’s Cover Letters, Research
& Teaching Statements. A. Green. Univ. of
How to Choose Your Ideal Career. B. Lindstaedt. UCSF.
Responsible Conduct of Research Part 3: Best
Practices: Publication Practices & Authorship,
Conflicts of Interest, and Research. S. Sodeke, T.
Networking with Strangers is Required for Your Future.
Handshakes, Eye Contact, Small Talk: How to
Successfully Network at a Conference. N. Saul. UCSF.
Nailing the Job Talk & Interview Prep. A. Green. Univ. of
Job Search in Academia & Industry. D. Behrens. Univ.
of California, Berkeley.
362. TANG PRIZE IN BIOPHARMACEUTICAL
SCIENCE AWARD LECTURE
Lecture
(Sponsored by: Tang Prize Foundation, Taiwan)
Tue. 3:00 pm—San Diego Convention Center, Room 33ABC
Cancer Immunotherapy by PD-1 Antibody. T. Honjo.
Kyoto Univ. Grad. Sch. of Med.
109
T
U
E
ANATOMYTUESDAY
Anatomy
363. CLINICAL APPROACH IN
CARDIOVASCULAR RESEARCH
Hybrid Symposium
(Cosponsored by: Brazilian Society of Anatomy)
Tue. 8:30 am—San Diego Convention Center, Room 10
Chaired: R.H. Cabral
365. WHAT CAN WE DO WHEN IT ALL FALLS
APART? REMEDIATION AND HOW TO HELP
STUDENTS WHO ARE STRUGGLING
Hybrid Symposium
Chaired: P. Husmann
Education
8:30 363.1
Parietal Valve of the Coronary Sinus:
Morphological Features and Clinical Importance. N.E.V. de
Prates. Univ. of São Paulo.
9:00 363.2
Comparative
Cardiac
Anatomy
and
Transmyocardial Laser Revascularization. R. Halti Cabral.
Univ. of São Paulo and Tiradentes Univ. Sch. of Med., Brazil.
9:30 363.3
Sodium Overload Induces Remodeling of
Aorta and Cardiac Arteries without Blood Pressure Changes in
Mice. S. Lacchini, J.C.S. Silva, C.T. Lima, K.A. Viegas, T.C.S.
Oliveira, P. Fiorino, V.M.A. Farah, R.H. Cabral. Univ. of São
Paulo, São Paulo State Univ., Botucatu and Presbiterian Univ.
Mackenzie, São Paulo.
9:45 363.4
Applied Anatomy of the Gastrocnemic Veins.
J. Aderval Aragão. Fed. Univ. of Sergipe and Tiradentes
Univ., Brazil.
8:30 365.1
Evaluating the Impact of Pre-matriculation
Instruction on Academic Performance in the Anatomical and
Physiological Sciences. D.E. Chico, S. Smith, W-J.A. Chen,
T.V. Peterson, A. Hairrell. Texas A&M Hlth. Sci. Ctr. Col.
of Med.
8:45 365.2
Prediction, Performance, and Adjustments:
Medical Students’ Reflections on the First Gross Anatomy
Exam. L.A. Hoffman. Indiana Univ. Sch. of Med., Fort Wayne.
9:00 365.3
Early Interventions: Promoting Success to
Prevent Remediation. A. Schutte, E. Kalb. Indiana Univ. Sch.
of Med. - Evansville.
9:30 365.4
Remediation in an Integrated Medical School
Curriculum – Lessons Learned. P. Ward. West Virginia Sch. of
Osteo. Med.
364. CRANIAL SUTURES AND THE PERIODONTAL
LIGAMENT - THE SOFT FORCES BEHIND
SHAPING THE SKULL OR TEETH
366. WRITTEN AND VISUAL COMMUNICATION:
DEVELOPING AN OUTSTANDING ABSTRACT
AND POSTER
Symposium
Symposium
(Cosponsored by: AAA’s Advisory Committee for
Young Anatomists)
Chaired: A. Burrows
Bones/Muscle/Connective Tissue
8:30 364.1
Supernumerary Sutures in the Zygoma and
Their Impacts on Skull Modularity and Biomechanics. Q.C.
Wang, P.C. Dechow. Texas A&M Univ. Baylor Col. of Dent.
9:00 364.2
Cranial Fibrous Connective Tissue Joints and
Experiments in Their Growth. C.D. Byron. Mercer Univ., GA.
9:30 364.3
Transcriptional Control of Cranial Suture
Development. R. Maxson, C. Teng, M. Ting, G. Crump. Univ.
of So. California.
Tue. 8:30 am—San Diego Convention Center, Room 7B
Cochaired: K. Brown and L. Jerome-Majewska
Career Development
Participants should sign up ahead of time and are asked
to bring their own abstract/poster to the session. This is to
help prepare for future meeting presentations, not for the
current meeting.
367. CARDIOVASCULAR BIOLOGY PLATFORM
Platform
Georgios Kararigas is competing as a finalist in the
Postdoctoral Platform Presentation Award and Vanessa Vrolyk
is competing as a finalist in the Langman Graduate Platform
Presentation Award
110
TUESDAYANATOMY
10:30 367.1
Lung
Inflammation
and
Pulmonary
Intravascular Macrophage Recruitment in L-Arginine-Induced
Acute Necrotizing Pancreatitis in Mouse. V. Vrolyk, B.
Wobeser, L. Khanh, B. Singh. Western Col. of Vet. Med.,
Univ. of Saskatchewan.
10:45 367.2
Repression but Not Deletion of β-Catenin
Contributes to Heart Failure. G. Kararigas, L.C. Zelarayan, K.
Toischer, H. Summer, I. Baczko, S. Golz, G. Hasenfuss, H.
Jarry, V. Regitz-Zagrosek. Charité Univ. Hosp., Berlin, GeorgAugust-Univ. Goettingen and Bayer HealthCare, Wupperal,
Germany and Univ. of Szeged, Hungary.
11:15 367.4
Ambient Ultra Fine Particle Impair Vascular
Repair via Notch Signaling. K.I. Baek. UCLA.
11:30 367.5
The Methyl Donor Betaine Prevents Congenital
Defects Induced by Prenatal Alcohol Exposure. M. Watanabe,
G. Karunamuni, Y.Q. Doughman, M.M. Sheehan, P. Ma, L.M.
Peterson, K.K. Linask, M.W. Jenkins, A.M. Rollins. Case
Western Reserve Univ. and Univ. of South Florida.
11:45 367.6
Reelin
Signaling
in
Cardiovascular
Development. D. Kim, A. Poles, G. Gorski, C.J. Hatcher.
Philadelphia Col. of Osteo. Med.
368. FORM AND FUNCTION PLATFORM
Platform
Chaired: M. Serrat
Megan Holmes is competing as a finalist in the Postdoctoral
Platform Presentation Award
10:30 368.1
The Dynamic Ontogenetic Structure of
Mandibular Morphological Integration. M.A. Holmes, M.A.
McNulty, J.C. Mussell, V.B. DeLeon. Sch. of Med., Duke
Univ., LSU Sch. of Vet. Med., Baton Rouge, LSU Hlth. Sci. Ctr.,
New Orleans and Univ. of Florida.
10:45 368.2
Comparison of Morphology and Bending
Mechanics of Femora in Response to Chronic Exercise
in Three Strains of Mice. K.M. Middleton, S.J. Peacock,
B.R. Coats, J.K. Kirkland, T. Garland; Jr. Univ. of MissouriColumbia, Saint Louis Col. of Pharm., Michigan State Univ. and
Univ. of California, Riverside.
11:00 368.3
Novel Findings in Rodent Pelvic Limb Anatomy.
H.A. Richbourg, M.J. Martin, M.A. McNulty. LSU Sch. of
Vet. Med.
11:15 368.4
Variation in Sexual Dimorphism of Mouse Os
Coxae Shape, Volume, and Bone Mineral Density in Response
to Selection for High Voluntary Wheel Running. H. Schutz,
K. Braaten-Fierros, C. Higginbotham, H.A. Jamniczky,
E.R. Donovan, T. Garland; Jr. Pacific Lutheran Univ.,
Cumming Sch. of Med., Univ. of Calgary, Canada and Univ. of
California Riverside.
11:30 368.5
Differences in Anterior Cruciate Ligament Fiber
Orientation between Digitigrade and Palmigrade Animals. A.A.
Ruth, T. Hieironymus, C.O. Lovejoy. Kent State Univ. and
Northeast Ohio Med. Univ.
11:45 368.6
Human Achilles and Equine Navicular
Apparatus: A Structural and Functional Comparison of Two
Premier Enthesis Organs. M.L. Osborn, U. Blas-Machado,
E.W. Uhl. Univ. of Georgia Col. of Vet. Med.
369. ANATOMY EDUCATION PLATFORM 2
Platform
Cochaired: V.D. O’Loughlin and K. Metzger
Education
Evidence-Based Approaches to Anatomy Education
10:30 369.1
Student Approaches to Anatomy Learning
Are Influenced by Clinically Relevant Peer-Peer Teaching. M.
Lazarus, J. Dos Santos, P. Haidet, T. Whitcomb. Monash
Univ., Australia and Penn State
10:45 369.2
The Embryology Educator Experience: A
Comprehensive Survey of Faculty and the Generation of
a Phenomenology of Embryology Education. K. Cassidy.
Indiana Univ.
11:00 369.3
Student Perspectives on General Learning
Compared to Learning Anatomy. A. Notebaert. Univ. of
11:15 369.4
Dissecting the Development of Clinical
Reasoning in the Gross Anatomy Laboratory. G. Rae, A.C.
Karpinski, R. McGoey. LSU Hlth. Sci. Ctr., New Orleans and
Kent State Univ. Col. and Grad. Sch. of Educ.
11:30 369.5
Comparison of Temporal Variations in
Ultrasound Training in Four Novice Groups. C. Elzie, A.P.
Trace, B. Knapp, F. Toreno, R. Conran, C. Goodmurphy.
Eastern Virginia Med. Sch.
11:45 369.6
Preliminary Results of a National Survey on
the Integration of Anatomical Variations in Medical School
Curricula. C. Goldberg, D. Royer. Univ. of Colorado Anschutz
Med. Campus.
370. PUBLISHING SUCCESS: HOW TO SUCCEED
WHEN SUBMITTING TO AAA JOURNALS
Symposium
(Sponsored by: AAA Journals: Anatomical Sciences
Education, Developmental Dynamics and The
Anatomical Record)
Chaired: S. Miller
Career Development
10:30
Publication Metrics and Evaluators of Success. P. Antin.
Univ. of Arizona.
11:00 Ethics in Scientific Publishing. K. Albertine. Univ.
of Utah.
11:30 Publishing Educational Research Manuscripts. R.
Drake, W. Pawlina. Cleveland Clinic Lerner College
of Medicine, Mayo Clinic College of Medicine.
111
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ANATOMYTUESDAY
371. NEUROBIOLOGY AWARD HYBRID
Hybrid Symposium
Tue. 2:00 pm—San Diego Convention Center, Room 10
Chaired: B. Allman
Neurobiology
Neurobiology
C.J. Herrick Award Lecture in Neuroanatomy featuring 2016
Young Investigator Award Recipient, Hillel Adesnik.
Innocent Edagha is competing as a finalist in the Postdoctoral
Platform Presentation Award and Amanda White is competing as
a finalist in the Langman Graduate Platform Presentation Award
2:00 371.1
New Approaches and Insights Into Cortical
Microcircuits. H. Adesnik, A. Mardinly, N. Pegard, I.
Oldenburg, L. Waller. Univ. of California, Berkeley.
2:30 371.2
Microscopic
Evaluation
of
Synaptic
Connectivity and Network Formation in Primary Hippocampal
Neurons. P. Verstraelen, J.R. Detrez, I. Pintelon, R. Nuydens,
T. Meert, W. De Vos, J-P. Timmermans. Univ. of Antwerp and
Janssen Pharmaceut., Beerse, Belgium.
2:45 371.3
Colonic Dysfunction following Acute Spinal
Cord Injury: Oxidative Damage to Interstitial Cells of Cajal?
A.R. White, G.M. Holmes. Penn State Col. of Med.
3:00 371.4
Cerebellar Neurotoxicity of ArtemetherLumefantrine in Prophylactic, Suppressive and Curative
Experimental Malaria Models. I.A. Edagha, G.J. Ekandem,
U.M. Ekanemesang. Univ. of Uyo and Obong Univ., Nigeria.
3:15 371.5
Behavioral Evidence of Transient versus
Persistent Tinnitus Induced by Loud Noise Exposure in a
Novel Rat Model. K. Beh, M. Typlt, G. Sigel, A. Schormans,
D. Stolzberg, B.L. Allman. Univ. of Western Ontario. (561.12)
372. THE ROLE OF MICRORNAS IN DEVELOPMENT
Symposium
Symposium
Tue. 2:00 pm—San Diego Convention Center, Room 7B
Chaired: T. Ritter
Cell Biology
2:00 373.1
Extracellular
Vesicles
Derived
from
Mesenchymal Stem Cells for Treatment of Ocular Surface
Injuries. T. Ritter, C. Lal, O. Treacy, G. O’Malley, M. Naughton,
S. Naicker, P. Lohan, H.M. Subhash, A. Ryan, G. Fahy, M.
Leahy, M.D. Griffin, S. Rani. Sch. of Phys., Univ. Hosp.,
Galway, Natl. Univ. of Ireland.
2:30
The Role of Stem Cell Exhaustion in Aging and
Disease: Implications for Stem Cell Therapy. J. Huard. Univ. of
Texas Hlth. Sci. Ctr. at Houston.
3:00 373.2
Exosomes and Their RNA Contents as
Mediators of Therapeutic Regeneration. E. Marban. CedarsSinai Heart Inst.
374. HENRY GRAY DISTINGUISHED EDUCATOR
AWARD SYMPOSIA
Award Lecture
Education
4:00 374.1
On the Way to Virtual. R.W. Ogilvie. Med.
Univ. of South Carolina and Univ. of South Carolina.
375. HENRY GRAY SCIENTIFIC AWARD SYMPOSIA
Chaired: B.A. Amendt
Award Lecture
Bones/Muscle/Connective Tissue
2:00 372.1
MicroRNA
Regulation
of
Craniofacial
Development Using New Biotechnology: Inhibition ofmIRr
Families in Transgenic Mice and Cells. B.A. Amendt, H. Cao,
S. Eliason. Univ. of Iowa and Houston Methodist.
2:30 372.2
MicroRNA Regulation of Early Mammalian
Development. R.J. Parchem. Baylor Col. of Med.
3:00 372.3
MicroRNA in Cardiac Arrhythmias. J. Wang, Y.
Bai, N. Li, W. Ye, M. Zhang, S.B. Greene, Y. Tao, Y. Chen, X.H.T.
Wehrens, J.F. Martin. Baylor Col. of Med. and Tulane Univ.
112
373. PARACRINE EFFECTS OF STEM AND
PROGENITOR CELLS
4:30 375.1
The Repairable Brain: An Anatomists View.
J.R. Sladek; Jr. Univ. of Colorado, Aurora.
TUESDAYBIOCHEMISTRY
379. CHROMATIN REMODELING AND EPIGENETICS
Plenary
Symposium
8:00
8:05 376.1
Everything That Matters in Biomedicine Builds
on Basic Science. F.S. Collins. OD, NIH.
377. BERT AND NATALIE VALLEE AWARD IN
BIOMEDICAL SCIENCE LECTURE
Award Lecture
8:55
9:00 377.1
DNA Excision Repair Map of the Human
Genome at Single Nucleotide Resolution. A. Sancar. Univ. of
North Carolina at Chapel Hill Sch. of Med.
378. CHEMICAL BIOLOGY APPROACHES TO
UNDERSTAND GLYCAN-RELATED DISEASES
Symposium
Tue. 9:45 am—San Diego Convention Center, Room 1A
Chaired: L. Wells
9:45
9:50 378.1
Activity-Based
Glycosidase
Profiling:
Monitoring Glycosphingolipid Metabolism in Health and
Disease. H. Overkleeft. Leiden Univ., Netherlands.
10:15
A New Selective Probe for Visualization and
Identification of O-GlcNAc-Modified Proteins in Cells. P.G.
Wang, J. Li, J. Wang, L. Wen, S. Li, H. Zhu, C. Ma, X. Li.
Georgia State Univ. and Col. of Pharm., Nankai Univ., China.
(616.2)
10:30 378.2
Photocrosslinking Sugars Capture GlycanDependent Interactions. J. Kohler, S-H. Yu, A.C. Rodriguez.
Univ. of Texas Southwestern.
10:55
Bioengineering Proteoglycan-Based Matrices
for Blood Contacting Applications. M. Lord, C. Chuang, J.
Rnjak-Kovacina, B. Cheng, G. Lyons, J. Whitelock. Grad.
Sch. of Biomed. Engin., Univ. of New South Wales, Univ.
of Copenhagen, Sydney Med. Sch., Royal Prince Alfred
Hosp., Univ. of Sydney and Sydney Head and Neck Cancer
Inst. (622.2)
11:10
ABO Blood Type Correlates with Survival on
Prostate Cancer Vaccine Therapy. J. Gildersleeve. NCI at
Frederick. (1095.5)
11:25 378.3
O-GlcNAc
Occurs
Cotranslationally
to
Stabilize Nascent Polypeptides. D. Vocadlo, Y. Zhu, T-W. Liu,
S. Cecioni, R. Eskandari, W. Zandberg, L. Willems. Simon
Fraser Univ., Canada.
11:50
Discussion.
Chaired: B. Ren
9:45
9:50 379.1
Reversible RNA Methylation in Gene
Expression Regulation. C. He. Univ. of Chicago and HHMI.
10:15
Chromatin Remodeler EP400 Deposits H3.3
Into Promoters and Enhancers during Gene Activation. S.K.
Pradhan, T. Su, L. Yen, K. Jacquet, J. Cote, S. Kurdistani, M.
Carey. UCLA and Laval Univ. Cancer Res. Ctr., Quebec. (803.9)
10:30 379.2
Mechanism and Regulation of the SWI/
SNF Family of ATP-Dependent Chromatin Remodelers. B.
Bartholomew, P. Sen, S. Kundu, S. Hailu, J. Persinger, A.
Hada, Y. Lu, J. Luo, J. Ranish. MD Anderson, Smithville, Univ.
of Pennsylvania and Univ. of Washington.
10:55
Epigenetics Impacts Copy Number Heterogeneity
and Drug Resistant Gene Selection. J.R. Whetstine, J.C. Black,
S. Mishra, B. Sexton, C. Van Rechem, S. Murphy. MGH Cancer
Ctr. and Harvard Med. Sch., Charlestown. (802.10)
11:10
Structural
Basis
for
Histone
H2B
Deubiquitination by the SAGA DUB Module. M.T. Morgan,
M. Haj-Yahya, A.E. Ringel, P. Bandi, A. Brik, C. Wolberger.
Johns Hopkins Med. Inst., Ben Gurion Univ. of the Negev and
Technion-Israel Inst. of Technol. (803.14)
11:25 379.3
Structural and Functional Analysis of Histone
Chaperones. Y. Gu, S. Bergeron, D. Krzizike, K. Luger. Univ.
of Colorado at Boulder.
11:50
Discussion.
380. CHEMICAL COMMUNICATION,
BIOLOGICAL REGULATION
Symposium
Tue. 9:45 am—San Diego Convention Center, Room 6C
Chaired: E. Carlson
9:45
9:50 380.1
Imaging
Cell-Cell
Interactions
with
Bioluminescent Probes. J. Prescher. Univ. of California, Irvine.
10:15
Design and Development of Chemically Gated
Artificial Regulatory Domains. D.T. Cunningham-Bryant. Univ.
of Washington. (809.1)
10:30 380.2
Understanding the Regulation of Ferroptosis.
S. Dixon. Stanford Univ.
10:55
Engineered
Caspases
with
Altered
Specificities Enable Identification of Exosites. J.A. Hardy, M.
Hill, D.J. MacPherson, P. Wu, O. Julien, J.A. Wells. Univ. of
Massachusetts Amherst and UCSF. (842.10)
11:10
Determination of HNO-Derived Modifications
on the Cardiac Protein Phospholamban. G. Keceli, A.
Majumdar, C.N. Thorpe, J.E. Mahaney, N. Paolocci, J.P.
Toscano. Johns Hopkins Univ., Edward Via Col. of Osteo.
Med., VA and Johns Hopkins Med. Instns. (1092.7)
113
T
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BIOCHEMISTRYTUESDAY
11:25 380.4
Metabolic
Control
Interaction. M. Burkart. UCSD.
11:50
Discussion.
via
Protein-Protein
381. INTEGRATIVE PROTEOMICS OF
PROTEIN COMPLEXES
Symposium
Tue. 9:45 am—San Diego Convention Center, Room 6D
Chaired: A-C. Gingras
9:45
9:50 381.1
Integrative Methods for Elucidating the
Structure and Function of Cellular Machines. B.T. Chait.
Rockefeller Univ.
10:15
Understanding
the
Lipid
Mediated
Oligomerisation in Membrane Proteins. K. Gupta, C.
Robinson. Univ. of Oxford. (819.13)
10:30 381.2
Mapping
Dynamic
Protein
Interaction
Landscapes in Saccharomyces cerevisiae Using a Novel
Whole Network Enrichment Approach. J. Yates, B.D. Stein,
D. Calzolari, M. Lavallee-Adam. The Scripps Res. Inst. and
Qualcom, San Diego.
10:55
Information Extraction from Native Mass
Spectra. S. Guan. UCSF. (819.14)
11:10
Dynamic Organellar Maps, a Tool to Study
Proteome-Wide Subcellular Localization Changes. D. Itzhak,
S. Tyanova, J. Cox, M. Mann, G. Borner. Max Planck Inst. of
Biochem., Martinsried. (819.3)
11:25 381.3
Defining Interaction and Structural Dynamics
of Protein Complexes Using Integrated Mass Spectrometry
Approaches. L. Huang. Univ. of California, Irvine.
11:50
Discussion.
382. TARGETED THERAPIES
Symposium
Tue. 9:45 am—San Diego Convention Center, Room 6E
Chaired: F. Sicheri
9:50 382.1
Kinases as Molecular Switches: Catalytic and
Non-catalytic Functions of BRAF Reveal Novel Insights into
Oncogenic Activation. S. Malek, S. Foster, D. Whalen, A. Ozen,
J. Haling, J. Sudhamsu, I. Yen, J. Yin, G. Hatzivassiliou,
A. Shaw, C. Yu, C. Eigenbrot, G. Manning, N. Skelton, S.
Hymowitz. Genentech.
10:15
ProKinO: A Unified Resource for Mining the
Cancer Kinome. N. Kannan. Univ. of Georgia. (1107.4)
10:30 382.2
Targeting Tumors Driven by VHL or IDH
Mutations. W. Kaelin. Dana-Farber Cancer Inst. and Brigham
and Women’s Hosp., Harvard Med. Sch., HHMI.
10:55
Covalent
Inhibition
of
ERK
Docking
Interactions. T.S. Kaoud, W.H. Johnson, A. Piserchio, N.D.
Ebelt, M. Warthaka, M. Cano, R. Sammons, Q. Wang, P. Ren,
R. Ghose, K.N. Dalby. Univ. of Texas at Austin, Fac. of Pharm.,
Minia Univ., Egypt and City Col. of New York. (856.11)
114
11:10
Clonal Evolution of the HER2 L755S Mutation
Leads to Acquired HER-Targeted Therapy Resistance That
Can Be Reversed by the Irreversible HER1/2 Inhibitor Afatinib.
X. Xu, A. Nardone, H. Hu, L. Qin, S. Nanda, T. Mitchell,
M. Shea, L. Heiser, N. Wang, K. Covington, E. Chen, A.
Renwick, T. Wang, C. De Angelis, A. Contreras, C. Gutierrez,
S. Fuqua, G. Chamness, C. Shaw, D. Wheeler, J. Gray, S.
Hilsenbeck, M. Rimawi, K. Osborne, R. Schiff. Baylor Col. of
Med., Oregon Hlth. & Sci. Univ. and MD Anderson Cancer Ctr.,
Houston. (1107.5)
11:25 382.3
Disrupting Adaptive
Bypass
Pathways
Activated by Targeted Kinase Inhibitors. G.L. Johnson. Univ.
of North Carolina Sch. of Med.
11:50
Discussion.
383. NAFLD: METABOLIC INSIGHT INTO THE
ENZYMATIC PLAYERS
Symposium
Tue. 9:45 am—San Diego Convention Center, Room 6F
Chaired: D.D. Moore
9:45
9:50 383.1
Posttranscriptional Regulation of Lipogenesis.
J.D. Horton. Univ of Texas Southwestern Med. Ctr.
10:15
Palmitoleate Protection against PalmitateInduced Cholangiocyte Lipoapoptosis Is Sensitive to Pertussis
Toxin. S.K. Natarajan, M.A. Walker, M. Toews, J.L. Mott. Univ.
of Nebraska Med. Ctr. (870.5)
10:30 383.2
Thioesterase Superfamly Member 2: Metabolic
Control of Hepatic Fatty Acid Channeling and Pathogenic Role
in Non-alcoholic Fatty Liver Disease. D.E. Cohen. Brigham
and Women’s Hosp./Harvard Med. Sch.
10:55
Cyclin D1 Regulates Adipose Triglyceride
Lipase to Influence Hepatic Lipid Droplet Metabolism and Cell
Proliferation. J. Ploeger, S. Kamarajugadda, D. Mashek, J.H.
Albrecht. Univ. of Minnesota. (871.1)
11:10
Phosphatidylcholine
Transfer
Protein
Regulates Lipid Droplet Morphology in Experimental Nonalcoholic Steatohepatitis. H.T. Nicholls, J. Song, J. Wu, J.L.
Hornick, D.E. Cohen. Brigham and Women’s Hosp. and
Harvard Med. Sch. (1128.1)
11:25 383.3
Interactions of Branched-Chain Amino Acids
and Lipids in Metabolic Disease. C. Newgard. Duke Univ.
11:50
Discussion.
384. DEVELOPING AND SHARING BEST PRACTICES:
FROM CONCEPTS TO CLASSROOM
Symposium
Chaired: J.E. Bell
This session will bring together experienced and early
career educators to learn about resources for course materials,
assessment tools and teaching the foundational concepts of
biochemistry and molecular biology.
TUESDAYBIOCHEMISTRY
Invited Speakers: Ann Aguanno, Marymount Manhattan
College, Pam Mertz, St. Mary’s College of Maryland, Jessica
Schrader, Eastern Florida State College, Marilee Benore,
University of Michigan, Dearborn
385. THE DO’S AND DON’TS OF DATA ANALYSIS
AND REPORTING
Workshop
(Sponsored by: Journal of Biological Chemistry)
Tue. 12:30 pm—San Diego Convention Center, Room 6A
Chaired: F.P. Guengerich
386. ASBMB MERCK AWARD LECTURE
Award Lecture
4:30
Tripartite DNA Lesion Recognition and
Verification by XPC, TFIIH, and XPA in Nucleotide Excision
Repair. F.M. Golebiowski, C-L. Li, Y. Onishi, N.L. Samara, K.
Sugasawa, W. Yang. NIDDK, NIH, Inst. of Molec. Biol., Acad.
Sinica, Taipei and Kobe Univ., Japan. (793.2)
4:45 389.2
Mechanism of Structure-Selective Nucleases.
M. Nowotny. Intl. Inst. of Molec. and Cell Biol., Warsaw.
5:10
Base Excision Repair of Bulky DNA Adducts
Generated by the Antitumor Drug Yatakemycin. E.A. Mullins,
R. Shi, Y. Igarashi, B.F. Eichman. Vanderbilt Univ. and Toyama
Prefect. Univ. (791.2)
5:25
Kinetic Mechanism for Binding and Flipping of
Damaged Bases by DNA Repair Dealkylases. P. O’Brien. Univ.
of Michigan. (574.2)
5:40 389.3
The Replication Machinery Encoded by
SCCmec and Related Mobile Genetic Elements. P.A. Rice,
I. Mir-Sanchis, S. Boyle-Vavra, Y.Z. Pigli. Univ. of Chicago.
6:05
Discussion.
390. STRUCTURAL STUDIES OF COMPLEX SYSTEMS
(Sponsored by: Merck & Co., Inc.)
Symposium
Tue. 4:00 pm—San Diego Convention Center, Room 6C
2:00
2:05 386.1
Prospects for Noncoding RNA Discovery in
Bacteria. R.R. Breaker. Yale Univ., HHMI.
387. WILLIAM C. ROSE AWARD LECTURE
Award Lecture
2:35
2:40 387.1
When Good Ribosomes Go Bad. S.J. Baserga,
K.L. McCann, T. Teramoto, J. Zhang, T.M. Tanaka Hall. Yale
Univ. Sch. of Med. and NIEHS, NIH, Research Triangle Park.
388. HERBERT A. SOBER LECTURESHIP
Award Lecture
3:10
3:15 388.1
The Nanodisc Platform for Determining the
Structure and Function of Membrane Proteins. S.G. Sligar.
389. STRUCTURAL INSIGHTS INTO DNA REPAIR
Symposium
Chaired: A. Sfeir
4:00
4:05 389.1
The Double Edged Sword of DNA Repair.
C. Kisker, J. Kuper, C. Braun, A. Elias, G. Michels, A.
Poterszman, J-M. Egly. Univ. of Würzburg, Germany and
CNRS, Univ. of Strasbourg, France.
T
U
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Chaired: TBD
4:00
4:05 390.1
Snapshots of Benzylsuccinate Synthase:
Getting a Handle on Toluene Degradation. C.L. Drennan, M.A.
Funk. MIT and HHMI, Cambridge, MA.
4:30
Biochemical
Characterization
of
Two
Evolutionary Distant Ten-Eleven Translocation Enzymes and
Their Utility in 5-Methylcytosine Sequencing in the Genomes
at Single-Base Resolution. L. Saleh, E. Tamanaha, R. Vaisvila,
J.E. Pais, N. Dai, S. Guan, I.R. Corrêa; Jr., Y. Zheng. New
England Biolabs. (834.2)
4:45 390.2
Learning Drug Design from Nature – The
Substrate-Protein and Protein-Protein Interactions of Fatty
Acid and Polyketide Mega-Synthases. S-C. Tsai. Univ. of
California, Irvine.
5:10
Protein-Protein Interactions Reduce Ca2+Requirements for Transglutaminase 2 Mediated Posttranslational Modifications of α-Synuclein. T.N. Zeczycki, J.S.
Viscomi. Brody Sch. of Med. at East Carolina Univ. (1083.16)
5:25
Histone Deacetylase 6: Structure, Mechanism,
and Inhibitor Selectivity. Y. Hai, D. Christianson. Univ. of
Pennsylvania. (1083.1)
5:40 390.3
Serial Femtosecond Crystallography Opens a
New Era in Membrane Protein Structural Biology. P. Fromme.
Biodesign Inst., Arizona State Univ.
6:05
Discussion.
391. NEW FRONTIERS IN PROTEIN
QUALITY CONTROL
Symposium
Tue. 4:00 pm—San Diego Convention Center, Room 6D
Chaired: B.A. Schulman
4:00
115
BIOCHEMISTRYTUESDAY
4:05 391.1
Unconventional Protein Secretion and Protein
Quality Control. Y. Ye, J-G. Lee. NIDDK, NIH.
4:30
ER Protein Quality Control and Lipid Droplets:
Unexpected Functional Connections. J.A. Olzmann. Univ. of
California, Berkeley. (816.5)
4:45 391.2
Rqc2p and 60S Ribosomal Subunits
Mediate mRNA-Independent Elongation of Nascent Chains.
O. Brandman. Stanford Univ.
5:10
Elucidating
ER-Associated
Degradation
Pathway for GABAA Receptors. T. Mu. Case Western Reserve
Univ. (598.9)
5:25
The
Degradation
Requirements
for
Topologically Distinct Quality Control Substrates in the Yeast
Endoplasmic Reticulum. C.J. Guerriero, K.R. Reutter,
A. Augustine, J.L. Brodsky. Univ. of Pittsburgh. (1063.2)
5:40 391.3
The E3 Ligase Listerin/Ltn1 Links RibosomeAssociated Protein Quality Control and Neurodegeneration.
C. Joazeiro. Heidelberg Univ. (ZMBH), Germany and The
Scripps Res. Inst.
6:05
Discussion.
392. NATURAL PRODUCT BIOSYNTHESIS FOR NEW
DRUG LEADS
Symposium
Tue. 4:00 pm—San Diego Convention Center, Room 6E
Chaired: C. Barry
4:00
4:05 392.1
Culture
Independent
Approaches
for
the Discovery of New Bacterial Metabolites. S.F. Brady.
Rockefeller Univ.
4:30
The Biosynthesis of the Indolic Acid Moiety
from the Antibiotic Nosiheptide. E. Badding, S. Booker. Penns
State Univ. and HHMI. (1101.2)
4:45 392.2
Semisynthetic
Natural
Products
for
Antibacterial Drug Discovery. R. Lee. St. Jude Children’s
Res. Hosp.
5:10
The Polyamine Pathway of Leishmania
donovani as a Potential Therapeutic Target. S. Roberts, D.
Paradis, J. Perdeh, J. Harrelson, B. Jan, P. Yates, B. Ullman.
Pacific Univ. and Oregon Hlth. & Sci. Univ. (1103.3)
5:25
Small Fungal Molecule Metabolites Targeting
Mosquito Midgut FREP1 Block Malaria Transmission. J. Li.
Univ. of Oklahoma. (627.6)
5:40 392.3
Nature Bank and Drug Leads for TB. R. Quinn.
Griffith Univ., Australia.
6:05
Discussion.
393. WALTER A. SHAW YOUNG INVESTIGATOR
AWARD IN LIPID RESEARCH
Award Lecture
(Sponsored by: Avanti Polar Lipids, Inc.)
Tue. 4:00 pm—San Diego Convention Center, Room 6F
Presented in the session, “Membrane Lipid Regulation”.
Refer to session 394 for additional details
4:00
116
4:00 393.1
Functional Lipidomics: From Lipid Timelines
to Regulation of Metabolic Networks. C.S. Ejsing. Univ. of
So. Denmark.
394. MEMBRANE LIPID REGULATION
Symposium
Tue. 4:00 pm—San Diego Convention Center, Room 6F
Chaired: J. Ntambi
4:00
4:05
Walter A. Shaw Young Investigator Award in
Lipid Research Introduction and Presentation.
4:10
Functional Lipidomics: From Lipid Timelines to
Regulation of Metabolic Networks. C.S. Ejsing. Univ. of So.
Denmark. (393.1)
4:35 394.3
Dynamic Regulation of the Signaling Lipid
Phosphatidylinositol 3,5-Bisphosphate. L.S. Weisman, N. Jin.
Univ. of Michigan.
5:00
Alterations in Acyl Phosphatidylglycerol
Levels in ΔpagP, ΔpldB, and Δcls Escherichia coli Leads to
Phenotypic Variance. M. Pourmaleki, T.A. Garrett. Vassar
Col., NY. (1133.2)
5:15 394.2
Regulation of Lipid Metabolism by SREBPs.
P. Espenshade. Johns Hopkins Univ. Sch. of Med.
5:40 394.1
Regulation of Yeast Pah1 Phosphatidate
Phosphatase in Lipid Synthesis. G.M. Carman. Rutgers Univ.
6:05
Discussion.
395. STRAIGHT FROM THE BENCH: RECENT
ADVANCES IN PROTEIN ENGINEERING
Symposium
Tue. 6:30 pm—San Diego Marriott Marquis & Marina
Hotel, San Diego Ballroom A
Chaired: M.R. White
Cochaired: D.L. Schmitt
6:30
6:45 395.1
Nearer to Nature: Design and Optimization of
Artificial Enzymes. D. Hilvert. ETH Zurich.
7:10
Tyro-3, Axl and Mer Chimeric Reporter
Systems Shows the Differential Regulations of the TAM
Family Receptor Tyrosine Kinases. S.G. Kimani, S. Kumar, S.
Kotenko, R. Birge. Rutgers-New Jersey Med. Sch. (1117.1)
7:20
Novel Cell-Penetrating Peptides Overcome
Endosomal Escape and Deliver Protein Cargos Into the Cell.
V. Ngwa, J. Salerno, S. Nowak, C. Chrestensen, J. McMurry.
Kennesaw State Univ. (631.2)
7:30
Altered DNA-Binding Specificity Transcription
Activator Variant Provides Key to Unlocking Gene Activation
Mechanism. A.N. Meyer, P.A. Weil. Vanderbilt Univ. Med. Ctr.
(803.11)
7:40
Atomic Force Microscopy Studies of
Conformational Changes in Proteins and Peptides.
N.T. Ploscariu, J. Tomich. Kansas State Univ. (823.3)
TUESDAYBIOCHEMISTRY
7:50
Amino Acid Selection during Teicoplanin
Biosynthesis Can Be Switched by a Point Mutation. T. Kittilä,
M.J. Cryle. Max Planck Inst. for Med. Res., Heidelberg and
EMBL, Monash Univ., Australia. (841.6)
8:00
Uptake
and
Lysosomal
Delivery
of
Recombinant Human Alpha-N-Acetylglucosamine-6-Sulfatase
to Mucopolysaccharidosis IIID Fibroblasts. D.R. Moen, D.M.
Wang, X. Zhang, S-h. Kan, J. Wood, S. Ekins, T-F. Chou, P.I.
Dickson. LA BioMed at Harbor-UCLA and Phoenix Nest Inc.
and Jonah’s Just Begun, Brooklyn. (1070.6)
8:10
Assessment of CCN2 Independent Modules
Regenerative Capacity on Osteoarthritis and Further Selecting
the Most Suitable among Them as a Potential Therapeutic
Drug. T. Abdelkader, E. Aoyama, T. Nishida, T. Hattori, D.
Janune, E.S. Hara, M. Ono, Y. Tabata, T. Kuboki, S. Kubota,
M. Takigawa. Okayama Univ. and Kyoto Univ. (1070.2)
8:20
Enhanced Sample Preparation for Proteomic
Analysis Utilizing Reversible Biotinylation and Polymer-Based
Protein Engineering. A. Lucas, C. Cummings, A. Russell, J.
Minden. Carnegie Mellon Univ. (821.1)
8:30
Development of “Inside-Out” PEGylated
Crosslinked Hemoglobin Polymers: A Novel HemoglobinBased Oxygen Carrier. K.D. Webster, D. Dahhan, C. Frosti,
W. Dean, J.B. Chaires, K.W. Olsen. Loyola Univ. Chicago and
Univ. of Louisville. (825.3)
8:40
Large-Scale
Structure-Based
Prediction
and Identification of Novel Protease Substrates Using
Computational Protein Design. M.A. Pethe, A. Rubenstein,
S.D. Khare. Rutgers and Ctr. for Integrative Proteomics Res.,
Piscataway. (601.2)
8:50 395.3
Controlling the Rate of Energy Transduction
in a Protein System through Coupling Pathway Redesign.
C.J. Wilson. Yale Univ.
9:15
Discussion.
7:22
Integrated Analysis of Posttranslational
Modification Proteomes Reveals Interactions and Cell Cycle
Regulatory Patterns In Toxoplasma gondii. N.C. Silmon de
Monerri, R.R. Yakubu, L.M. Weiss, K. Kim. Albert Einstein
Col. of Med. (864.13)
7:34
Proteome-Wide Structural Analysis of PTM
Hotspots Reveals Large Body of Putative Regulatory Elements
with Predicted Biological Function. H. Dewhurst, M. Torres.
Georgia Tech. (864.24)
7:46
Ate1-Mediated Posttranslational Arginylation
Is Essential for Stress Response Regulation and Mutagenesis
Suppression. A. Kumar, M.D. Birnbaum, W. Morgan, F. Zhang.
Univ. of Miami. (864.2)
7:58
Investigating the Mechanism by Which the
Small RNA MtlS Regulates the Mannitol Protein Transporter
at the Post-translational Level in Vibrio cholerae. E.E. Hansen,
M.C. Coyle, J.M. Liu. Pomona Col., CA. (595.3)
8:10
Evidence for the Interplay between Posttranslational Modifications in Regulating Mycobacterial
Sirtuin Activity. G.S. Yadav, S.K. Ravala, N. Malhotra, P.K.
Chakraborti. CSIR-Inst. of Microbial Technol., Chandigarh.
(1131.1)
8:22
Metabolite-Driven
Modifications:
Protein
Acylations Elucidate Substrate Metabolism in Syntrophic
Bacteria. H.H.T. Nguyen, P.H.N. Nguyen, R.P. Gunsalus, M.J.
McInerney, J.A. Loo, R.R. Ogorzalek Loo. UCLA and Univ. of
Oklahoma. (864.1)
8:34
Investigation into the Role of N-Terminal
Acetylation of ESAT-6 in Pathogenesis of Mycobacterium
tuberculosis. J.A. Aguilera, J. Sun. Univ. of Texas at El
Paso. (864.22)
8:46 396.2
Posttranslational Modifications in BacteriaHost Interaction. F. Shao. Natl. Inst. of Biol. Sci., Beijing.
9:11
Conclusion.
396. STRAIGHT FROM THE BENCH:
POSTTRANSLATIONAL MODIFICATIONS AND
THE MICROORGANISM RESPONSE
397. ASBMB WOMEN’S BMB SCIENTIST PANEL AND
NETWORKING EVENT
Symposium
Hotel, San Diego Ballroom C
Chaired: A. Hadjikyriacou
Cochaired: A.N. Patananan
Special Event
Each year, the ASBMB sponsors a session where women
scientists reflect on some aspect of their careers or general
issues surrounding women’s participation in science. Networking,
mentoring, refreshments, and fun. ASBMB members and
biochemistry attendees welcome.
Follow the conversation: #PTM
6:30
6:45 396.1
Arginine Methylation Modulates RNA Biology
of African Trypanosomes. L.K. Read. Univ. of Buffalo Sch.
of Med.
7:10
Specificity
of
Protein
Arginine
Methyltransferases: How Does the Trypanosoma brucei
PRMT7 Limit Its Activity to Monomethylation of Its Target
Proteins? K. Jain, R.A. Warmack, Y. Feng, E.W. Debler,
P. Stavropoulos, G. Blobel, S.G. Clarke. UCLA and The
Rockefeller Univ. (864.3)
398. MEET THE BIOARTIST
Special Event
Tue. 7:00 pm—Karl Strauss Brewing Company, 1157
Columbia St., San Diego, CA 92101
Join us for a discussion with the winning scientists behind the
images of the Annual FASEB BioArt Competition and more at the
Karl Strauss Brewing Company in downtown San Diego, where
the images will be on display throughout EB2016. Refreshments
available for purchase.
117
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NUTRITIONTUESDAY
Nutrition
400. USING THE NIH BODY WEIGHT PLANNER FOR
NUTRITION RESEARCH AND COUNSELING
(Sponsored by: ILSI NA Technical Committee on Protein)
Tue. 7:00 am—San Diego Convention Center, Room 32AB
Chaired: K.D. Hall
9:00
9:25
403. INTERNATIONAL FORUM – BRAZIL/ICAN
401. BIOLOGY OF LINEAR GROWTH: A GUIDE FOR
REDUCING CHILDHOOD STUNTING
International Forum
(Supported by International Colleges for the
Advancement of Nutrology )
Symposium
(Organized and Sponsored by: the International Colleges
for the Advancement of Nutrology (ICAN))
Tue. 8:00 am—San Diego Convention Center,
Ballroom 20D
Tue. 8:30 am—San Diego Convention Center, Room 33BC
Chaired: K.P. West, Jr.
Cochaired: A. Ferreira Heyn and R. Figueredo
Cochaired: K. Kraemer
Nutrition Across the Lifespan: From Pediatrics to
Geriatrics
8:00
8:10
Introduction: Keeping Biological Plausibility in View
When Setting Public Health Goals to Reduce
Childhood Stunting. K. West, Jr. Johns Hopkins
Bloomberg Sch. of Publ. Hlth.
Nutritional, Hormonal and Inflammatory Determinants of
Bone Development. J. Lui. NICHD, NIH.
Patterns of Normal Fetal and Postnatal Growth During
the 1st 1000 Days. M. Lampl. Emory Univ.
Efficacy of Maternal and Child Nutrition Interventions
to Improve Linear Growth. P. Christian. Johns
Hopkins Univ.
Linear Growth Beyond the 1st 1000 Days of Life: Is
There Catch-up Growth? Is it Healthy? A. Stein.
Emory Univ.
Discussion: Implications for Reducing Childhood
Stunting. K. Kraemer. Sight and Life.
8:40
9:00
9:20
9:40
Bailey. CDC, Natl. Ctr. for Hlth. Statistics, NIH Office
of Dietary Supplements and Purdue Univ.
Monitoring of Nutritional Status in NHANES through
Blood and Urine Biomarkers. C. Pfeiffer. CDC.
Statistical Approaches for Modeling Usual Intake Using
NHANES Data. K. Dodd. NIH, NCI.
8:30 Malnutrition in Hospitals. A. Ferreira Heyn, Sociedad
Paraguaya de Nutr., Paraguay
8:45 The Challenges of Obesity’s Pharmacotherapy.
D. Ribas Filho, Assn. de Nutrologia, Brazil
9:00 Collagen Supplement in the Prevention and Treatment
of Degenerative Osteoarthritis. M. Garcez Duarte,
Curitiba—Paraná, Brazil
9:15 Infertility and Oxidative Stress. V. Ferreira do Amaral,
Univ. Fed. do Paraná, Brazil
9:30 Obesity Comorbidities in Brazilian Children and
Adolescents. C.A. Nogueira-de-Almeida, Univ. de
Ribeirão Preto, Brazil
9:45
Questions & Answers.
404. DBC: DIETARY ANTIOXIDANTS
Minisymposium
402. NUTRITIONAL STATUS MONITORING IN THE
U.S. OVER 45 YEARS IN THE NATIONAL HEALTH
AND NUTRITION EXAMINATION SURVEY
(NHANES): UPDATES AND CHALLENGES
Symposium
Tue. 8:00 am—San Diego Convention Center, Room 31ABC
Chaired: N. Ahluwalia
Cochaired: C.J. Boushey
8:00
8:10
8:35
118
NHANES in Monitoring Nation’s Health and Nutrition:
Setting the Stage. N. Ahluwalia. CDC, Natl. Ctr. for
Hlth. Statistics.
Data Collection, Database Updates, and Findings from
the What We Eat in America (WWEIA) Component of
the NHANES. A. Moshfegh. USDA, Beltsville.
Dietary Supplements: Data Collection, Databases,
Total Intakes, and Trends in the U.S. J. Gahche, R.
Chaired: L. Gu
Cochaired: S. Moser
8:00 404.1
Protandim Treatment Causes Reversible
Nuclear Translocation of Nrf-2 and Activation of the Antioxidant
Response Element. N. Chevreau. LifeVantage Corp.,
Sandy, UT.
8:15 404.2
Effects of Acute n-3 Fatty Acid Administration
on Cardiac Lipid Metabolism and Ca2+ Homeostasis during
Ischemia-Reperfusion. H. Zirpoli, N. Quadri, K.M. O’Shea, R.
Ananthakrishan, M. Abdillahi, R. Rosario, R.J. Deckelbaum,
R. Ramasamy. Col. of P&S, Columbia Univ. Med. Ctr. and NYU
Med. Ctr.
8:30 404.3
Sweet Sorghum (Sorghum bicolor) Stalk
Extract, a Byproduct of Biofuel Production, Ameliorates
Systemic Oxidative Stress in a Murine Model of High-Caloric
Diet-Induced Obesity. L. Reddivari, R. Bhatnagar, A. Massey,
J. Vanamala. Penn State and Colorado State Univ.
TUESDAYNUTRITION
8:45 404.4
M-A-T (Mucuna, Ashwagandha and Tribulus)
Enhances Testosterone and Reduces Oxidative Stress: In Vivo
Model. V. Juturu, K. Sahin, F. Akdemir, C. Orhan, M. Tuzcu,
G. Turk, N. Sahin, I. Yilmaz. OmniActive Hlth. Technols. Inc.,
NJ and Firat Univ., Turkey.
9:00 404.5
Lycopene
Inhibits
Amyloid-β25-35-Induced
Apoptosis by Decreasing Intracellular and Mitochondrial Ros
Levels in Human Neuronal SH-SY5Y Cells. S. Hwang, J.W.
Lim, H. Kim. Col. of Human Ecol., Yonsei Univ., South Korea.
9:15 404.6
Broccoli (Brassica oleracea) Extract Combats
Streptozotocin-Induced Diabetes and Oxidative Stress in Rats.
S. Suresh, M.I. Waly, N. Guizani, M.S. Rahman. Col. of Agr.
and Marine Sci., Sultan Qaboos Univ., Oman.
9:30 404.7
Redox Modulation of Curcumin Stability:
Redox Active Antioxidants Increase Chemical Stability and
Biological Activity of Curcumin. G. Zhang, Y. Nimiya, W. Wang,
E. Decker. Univ. of Massachusetts Amherst.
9:45 404.8
Hydroxytyrosol Is More a More Potent
Antioxidant Than Tyrosol. J. Rodríguez-Morató, R. de la
Torre, J. Blumberg, C-Y.O. Chen. Hosp. del Mar Med. Res.
Inst., Barcelona, Pompeu Fabra Univ., Spain, Physiopathol. of
Obesity and Nutr., Madrid and Tufts Univ., Boston
ENERGY BALANCE, MACRONUTRIENTS AND
WEIGHT MANAGEMENT
Minisymposium
Chaired: S.K. Das
Cochaired: J.P. Karl
8:00 405.1
The Portion Control Strategies Trial: A YearLong Randomized Controlled Trial on the Impact of Portion
Control on Weight Change. B.J. Rolls, B.L. James, C.E.
Sanchez, L.S. Roe. Penn State.
8:15 405.2
A New Commercial Behavioral Weight Loss
Program: Effect of Program Location, Delivery Mode and
Participant Factors on Weight Loss. S.K. Das, C. Brown, J.
O’ Toole, S.B. Roberts. USDA at Tufts Univ. and Instinct Hlth.
Sci. LLC, Weston, MA.
8:30 405.3
Dietary Substitution of Whole Grains for Refined
Grains Favorably Effects Fiber Intake and Energy Metabolism
in Adults. J.P. Karl, M. Meydani, J.B. Barnett, S.M. Vanegas,
B. Goldin, H. Rasmussen, E. Saltzman, S.S. Jonnalagadda,
S.N. Meydani, S.B. Roberts. USDA at Tufts Univ., Tufts Univ.
Sch. of Med. and General Mills Inc., Minneapolis.
8:45 405.4
Comparison of Two Administration Forms
of a Highly Viscous Fibre Blend on Appetite and Glycemic
Response in Healthy Individuals. F. Au-Yeung, E. Jovanovski,
H. Ho, A. Zurbau, A.L. Jenkins, V. Vuksan. St. Michael’s Hosp.
and Univ. of Toronto.
9:00 405.5
FTO Genotype, Dietary Protein Intake and
Body Weight in a Population of Young Adults. J. Jamnik, D.
Merritt, A. El-Sohemy. Univ. of Toronto.
9:15 405.6
Predicting Initial Lipid Release from Masticated
Tree Nuts Using Mathematical Modelling. T. Grassby, Y. Shen,
L. Wagner, S. Beckett, W. Hall, S. Berry. King’s Col. London.
9:30 405.7
Hunger and Satiety Responses to Saturated
Fat-Rich Meals before and after a High PUFA Diet. J.A.
Cooper, J.L. Stevenson, C.M. Paton. Univ. of Georgia and
Texas Christian Univ.
9:45 405.8
Spatial Reorganization of Proopiomelanocortin
(POMC)-Expressing Neurons in the Arcuate Nucleus of POMCEGFP Mice Resistant or Prone to Obesity. D. Tomé, M. Soto,
C. Chaumontet, M. Guillaumin, S. Benoit, G. Fromentin, N.
Darcel. AgroParisTech, INRA, Univ. Paris-Saclay and Univ.
de Lorraine-Nancy.
406. NUTRITION AND GASTROINTESTINAL
FUNCTION: THE MICROBIOME AND BEYOND
Minisymposium
Chaired: K.A. Tappenden
Cochaired: H.D. Holscher
8:00 406.1
Gastrointestinal Microbial Changes following
Whole Grain Barley and Oat Consumption in Healthy Men and
Women. S.V. Thompson, K.S. Swanson, J.A. Novotny, D.J.
Baer, H.D. Holscher. Univ. of Illinois at Urbana-Champaign,
USDA, Beltsville, MD.
8:15 406.2
Walnut Consumption Influences the Human
Gut Microbiome. H.M. Guetterman, K.S. Swanson, J.A.
Novotny, D.J. Baer, H.D. Holscher. Univ. of Illinois at UrbanaChampaign and USDA, Beltsville, MD.
8:30 406.3
Utilizing Machine Learning Approaches
to Understand the Interrelationship of Diet, the Human
Gastrointestinal Microbiome, and Health. H. Guetterman, L.
Auvil, N. Russell, M. Welge, M. Berry, L. Gatzke, C. Bushell,
H. Holscher. Univ. of Illinois at Urbana-Champaign.
8:45 406.4
Impacts of Age, Snack Food, and Whole and
Refined Wheat on the Rat Fecal Microbiome. C. Cotton, K.
Westerman, D. Van Roosebeke, A.V. Kane, A. Tai, J.B.
Blumberg, C-Y.O. Chen, M.S. Obin. Tufts Univ. Friedman Sch.
of Nutr. Sci. and Policy, Tufts Med. Ctr., Tufts Univ. Sch. of Med.
and USDA at Tufts Univ.
9:00 406.5
Impact of Almond Consumption on the
Composition of the Gastrointestinal Microbiota of Healthy Adult
Men and Women. A.M. Taylor, K.S. Swanson, J.A. Novotny,
D.J. Baer, H.D. Holscher. Univ. of Illinois at Urbana-Champaign
and USDA, Beltsville, MD.
9:15 406.6
Trimethylamine-N-Oxide Biomarker Response
Is a Function of Dietary Precursor Intake and Gut Microbiota
Composition in Healthy Young Men. C.E. Cho, S. Taesuwan,
O.V. Malysheva, E. Bender, N.F. Tulchinsky, J. Yan, J.L.
Sutter, M.A. Caudill. Cornell Univ.
9:30 406.7
Differences in the Infant Gut Microbiota Related
to the Fatty Acid Composition of Human Milk: Results from
the GEHM Cohort. D.H. Taft, K.A. Dingess, C.J. Valentine,
B.S. Davidson, N.J. Ollberding, D.V. Ward, J.T. Brenna, R.J.
McMahon, A.L. Morrow. Cincinnati Children’s Hosp. and Med.
Ctr., Mead Johnson Nutr., Glenview, IL, Univ. of Massachusetts
Med. Sch. and Cornell Univ.
9:45 406.8
Formula Milk Alters Microbial Diversity in
Porcine Colon and Impacts Immune Response. M.K. Saraf,
A.K. Bowlin, S.V. Chintapalli, K. Shankar, T. LeRoith, M.J.
Ronis, T.M. Badger, L. Yeruva. Arkansas Children’s Nutr. Ctr.,
Univ. of Arkansas for Med. Sci., VA-MD Col. of Vet. Med. and
LSU Hlth. Sci. Ctr., New Orleans.
119
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NUTRITIONTUESDAY
407. NUTRITION ACROSS THE LIFESPAN:
NUTRITION, NEUROBIOLOGY, MOOD AND
BEHAVIOR
Minisymposium
Minisymposium
Nutrition RIS)
(Cosponsored by: Nutrition Translation RIS and Obesity
RIS )
Chaired: L. Sibeko
Chaired: N.A. Khan
Cochaired: M.D. Olfert
Cochaired: C. Castaneda-Sceppa
8:00 407.1
EGCG Decreases Mortality in a DoseDependent Fashion but Does Not Improve Cognition in Aged
Mice. B.D. Pence, T.K. Bhattacharya, J.L. Rytych, P. Park, J.M.
Allen, Y. Sun, R.H. McCusker, K.W. Kelley, R.W. Johnson,
J.S. Rhodes, J.A. Woods. Univ. of Illinois Urbana-Champaign.
8:15 407.2
Early Exposure to High-Sucrose Diet Triggers
Hippocampal Endoplasmic Reticulum-Stress in Young Rats.
A.M.A. Paes, B.A.S. Pinto, T.M. Melo, K.F.T. Flister, L.M.
França, L.Y. Tanaka, F.R.M. Laurindo. Fed. Univ. of Maranhão
and Univ. of São Paulo, Brazil.
8:30 407.3
DHA Status Is Related to Prefrontal CortexMediated Impulse Control in Adolescents. V.L. Darcey,
S. El Damaty, E.J. Rose, D.H. Fishbein, J.W. VanMeter.
Georgetown Univ. and Penn State
8:45 407.4
Blood Cholesterol in Late-Life and Cognitive
Decline: A Longitudinal Study of the Chinese Elderly. C. Ma, Z.
Yin, J. Luo, P. Zhu, X. Shi, X. Gao. Penn State, Chinese Ctr.
for Dis. Control and Prevent., Beijing.
9:00 407.5
Homocysteine Concentration Correlates with
Baseline Clinical Status and Predicts Outcomes in a Large,
Early Parkinson’s Disease Cohort (DATATOP). R. Green,
Y. Yelpaala, S. Catalya, P. Auinger, C. Christine. Univ. of
California Davis, Sacramento, Univ. of Rochester and UCSF.
9:15 407.6
Beneficial Interactions between B Vitamins
and Omega-3 Fatty Acids in the Prevention of Brain Atrophy
and of Cognitive Decline in Early Stage Alzheimer’s Disease.
D. Smith, H. Refsum, A. Oulhaj, C.A. de Jager, F. Jerneren.
Univ. of Oxford, Univ. of Oslo, United Arab Emirates Univ. and
Univ. of Cape Town.
9:30 407.7
Gray Matter Thickness of Inferior Frontal
Cortex Mediates the Relationship between Phosphatidylcholine
and Executive Functions in Healthy, Older Adults. M.K.
Zamroziewicz, T. Das, S.L. Pereira, A.K. Barbey. Univ. of
Illinois Urbana-Champaign and Abbott Nutr., Columbus, OH.
9:45 407.8
Changes in Eating Behaviors Are Associated
with Intentional Weight Loss following Intervention in Older
Women. A.C. Berg, K.B. Johnson, C.R. Straight, R.M.
Acitelli, P.J. O’Connor, E.M. Evans, M.A. Johnson. Univ.
of Georgia.
120
HEALTH DISPARITIES AND PROMOTING
HEALTH IN DIVERSE POPULATIONS
8:00 408.1
The Effects of Experimentally Manipulating
Social Status on Acute Eating Behavior: A Randomized,
Crossover Pilot Study. M. Cardel, S.L. Johnson, J. Beck, E.
Dhurandhar, A. Dulin-Keita, A. Tomczik, G. Pavela, T. Huo,
D. Janicke, K. Muller, J.C. Peters, J.O. Hill, D.B. Allison. Univ.
of Florida, Univ. of Colorado Denver, Aurora, Colorado State
Univ., Texas Tech Univ., Brown Univ. and Univ. of Alabama
at Birmingham.
8:15 408.2
The Relationship between Weight Loss Advice
from Friends on Self-Perception of Weight and Eating Habits.
T. Thibodeau, I. van Woerden, P. Ohri-Vachaspati, J. Huberty,
M. Bruening. Arizona State Univ.
8:30 408.3
Promotion of Drinking Water among Latino
Immigrant Youth. N. Barrett, U. Colón-Ramos, I. Rivera, W.D.
Evans, M. Edberg. George Washington Univ. Milken Inst. Sch.
of Publ. Hlth. and Rivera Group Inc., Washington, DC.
8:45 408.4
Nutrient Intake among Overweight/Obese
Hispanic Women Based on Type 2 Diabetes Diagnosis
Status. M. Arias-Gastelum, N.M. Lindberg, A.G. Rosales, M.
Petrovic, E.S. LeBlanc, V.J. Stevens, T.J. Kapka, R.T. Meenan,
S. Vega-López. Arizona State Univ., Kaiser Permanente Ctr.
for Hlth. Res., Portland and Virginia Garcia Mem. Hlth. Ctr.,
Hillsboro, OR.
9:00 408.5
Barriers and Facilitators to Healthy Eating: A
Transnational Comparison of Central American Communities
in a Socio-ecological Framework. M. Fuster, U. Colón-Ramos.
CUNY-Brooklyn Col. and George Washington Univ. Milken Inst.
Sch. of Publ. Hlth.
9:15 408.6
Associations between Dysfunctional Eating
Behaviors and Cardiovascular Risk among Latinos. A.A.
Lopez-Cepero, C.M. Frisard, S.C. Lemon, M.C. Rosal. Univ.
of Massachusetts Med. Sch.
9:30 408.7
Secular Trends in Regional Differences in
Biomarkers of Dietary Exposure and Inflammation among
American Adults: NHANES III, 1988-1994 to C-NHANES 19992010. A.K. Kant, B.I. Graubard. Queens Col. of CUNY and
NCI, NIH.
9:45 408.8
Racial/Ethnic and Income Disparities in
the Sodium Content of Packaged Food Purchases by U.S.
Households in the Past 15 Years. J.M. Poti, E. Dunford, B.M.
Popkin. Univ. of North Carolina at Chapel Hill.
TUESDAYNUTRITION
409. POLICY: INNOVATIONS IN MONITORING
HEALTH AND NUTRITION STATUS
410. NUTRITION EDUCATION: NUTRITION
EDUCATION AND BEHAVIOR CHANGE
Minisymposium
Minisymposium
(Sponsored by: Public Policy Committee)
Science RIS)
Chaired: A.H. Lichtenstein
Cochaired: S.D. Ohlhorst
Science Policy
8:00 409.1
Adherence Monitoring Tool for Controlled
Feeding Studies. D.J. Burnett, J.M. Peerson, B. Miller, L.C.
Welch, M.G. Witbracht, S. Krishnan, N.L. Keim. USDA and
Univ. of California, Davis.
8:15 409.2
Inter-finger Variability and Other Influencing
Factors for Using Reflectance Spectroscopy for Skin
Carotenoid Detection. L.D. Whigham, A.H. Redelfs. Paso del
Norte Inst. for Healthy Living, El Paso.
8:30 409.3
Skin Carotenoids as Biomarker for Vegetable
and Fruit Intake: Validation of the Reflection-Spectroscopy
Based “Veggie Meter”. I.V. Ermakov, L.D. Whigham, A.H.
Redelfs, L. Jahns, J. Stookey, P.S. Bernstein, W. Gellermann.
Image Technols. Corp., Salt Lake City, Paso del Norte Inst.
for Hlth. Living, El Paso, USDA, Grand Forks, San Francisco
Dept. of Publ. Hlth. and Univ. of Utah.
8:45 409.4
Understanding the Impacts of State Laws on
Child Nutrition Programs: An Argument for Employing New
Methodologies. A. Field, B. Fiese. Univ. of Illinois, Urbana.
9:00 409.5
Utilizing Smartphone Technology to Monitor
Improvements in the Healthiness of the Food Supply.
E. Dunford, M. Crino, B. Neal. Univ. of North Carolina at
Chapel Hill and George Inst. for Global Hlth., Sydney.
9:15 409.6
Diet Quality, Measured Using the Healthy
Eating Index-2010, Varies by Source Where Food Is Obtained
in the United States. M. Wilson, S. Krebs-Smith, J. Reedy, M.
Story, P. Britten, W. Juan. NCI, NIH, Duke Global Hlth. Inst.,
USDA, Alexandria, VA and FDA, College Park, MD.
9:30 409.7
Cereal Foods Consumption Trends and
Factors Associated with Changing Intake, among Western
Australian Adults, 1995 to 2012. C.M. Pollard, C. Pulker, X.
Meng, F. Denham, V. Solah, J.A. Scott, D.A. Kerr. Sch. of
Publ. Hlth., Curtin Univ., Dept. of Hlth. in Western Australia and
Flinders Univ., Australia.
9:45 409.8
Application of the Evidence Review Cycle
Model to Review Food and Health Evidence to Inform Canadian
Dietary Guidance Decision-Making. H. Lowell, A. Ellis, C.K.
Colapinto. Hlth. Canada, Ottawa.
Chaired: J. Banna
Cochaired: H. Muzaffar
8:00 410.1
Effect of Nutrition Education on Weight Gain
Prevention in Adult Women: Findings from a Randomized
Controlled Trial. C.J. Metzgar, S.M. Nickols-Richardson.
8:15 410.2
Effect of Nutrition Education with an Emphasis
on Consumption of Iron-Rich Foods on Hemoglobin Levels of
Pregnant Women in Ghana. G. Otoo, Y. Adam. Univ. of Ghana.
8:30 410.3
Diet Quality of a Pregnant Primarily African
American Cohort Residing in the Mississippi Delta: Delta
Healthy Sprouts. M.H. Goodman, J.L. Thomson, L.M.
Tussing-Humphreys. USDA, Stoneville, MS and Univ. of
Illinois at Chicago.
8:45 410.4
Online and In-Person Nutrition Education
Reduces Sodium Intake: A Randomized Trial to Assess
Knowledge, Self-Efficacy and Behaviors in WIC Participants.
L. Au, S. Whaley, N.J. Rosen, M. Meza, L.D. Ritchie. Univ.
of California, Berkeley, Publ. Hlth. Fndn. Enterprises WIC,
Irwindale, CA and Informing Change, Berkeley.
9:00 410.5
Social Media Usage Pattern among
Supplemental Nutrition Assistance Program Education Eligible
Individuals in Georgia. A. White, R. Hagues, A. Childers, J.S.
Lee, B. Olubajo, J. Phua. Univ. of Georgia and Samford Univ.
9:15 410.6
The Role of Grit in Body Weight Regulation
Over Time. C.J. Metzgar, S.M. Nickols-Richardson. Univ. of
Illinois at Urbana-Champaign.
9:30 410.7
Dietary Intake and Diet Quality of Low-Income
Adult Georgians Participating in Supplemental Nutrition
Assistance Program Education. J.S. Lee, J. Hibbs, J. Moore,
B. Olubajo, A. White, C. Bailey, M. Lewis. Univ. of Georgia.
9:45 410.8
What Can Nutrition Education Offer to Improve
Dietary Sodium Restriction Interventions for Heart Failure
Patients? M. Burgermaster, R. Rudel, J. Wessler, D.S. Seres.
Columbia Univ. Med. Ctr., New York Presbyterian Hosp.
411. OBESITY RIS ANNUAL BUSINESS MEETING:
HOT TOPIC DISCUSSION: GUT MICROBIOTA,
CAUSAL INFERENCE, AND OBESITY
RIS Forum
Tue. 9:30 am—San Diego Convention Center, Room 32AB
Chaired: D.B. Allison
121
T
U
E
NUTRITIONTUESDAY
412. NUTRITION, MICRORNAS AND HUMAN HEALTH
Symposium
10:30
11:00
11:30
12:00
Ballroom 20D
Symposium
Chaired: J. Zempleni
Chaired: L.P. Smith Taillie
Cochaired: S.A. Ross
Cochaired: Y. Segar
Education
Biological Activities of Dietary microRNAs. J. Zempleni.
Effects of Dietary Compounds on the Expression of
Genes Coding for Endogenous microRNAs. S. Ross.
NCI, NIH.
Bioinformatics Tools and Databases for the Analysis
of Nutrition, MicroRNAs and Human Health. J. Cui.
Regulation of Immune Function in Adipose Tissue by
microRNAs. B. Zhou. UConn Hlth.
413. PROGRAM EFFECTIVENESS FOR
ADDRESSING UNDERNUTRITION DURING THE
FIRST 1000 DAYS
11:30
11:50
122
Education
10:30
10:50
11:10
11:30
Priorities and Pitfalls for Powerful Postdoc Experiences.
S. Chang. Univ. of Texas MD Anderson Cancer Ctr.
The Future of the Postdoc: Thinking Outside the Training
Box. R. Wheeler. The Scripps Res. Inst.
Mind Your P’s and hD’s: What Else Can I Do With My
Degree? K. Gibbs, Jr. NIGMS, NIH.
Preparing for a Career in Industry: The First Job PostPhD. D. Bolster. PepsiCo.
PROTEIN INTAKE AND HEALTH IMPLICATIONS
Tue. 10:30 am—San Diego Convention Center, Room
31ABC
Nutrition Across the Lifespan: From Pediatrics to
Geriatrics
11:10
Career Development
Minisymposium
Cochaired: Z. Maalouf-Manasseh
10:50
Tue. 10:30 am—San Diego Convention Center, Room 33BC
Symposium
Chaired: M.L. Deitchler
10:30
414. AMID CONTROVERSY AND CAVEATS: THE
FUTURE OF THE POSTDOC
Effectiveness of Home-fortification Approaches in the
First 1000 days for Preventing Maternal and Child
Undernutrition: The Rang-Din Nutrition Study in
Bangladesh. K. Dewey. Univ. of California, Davis.
The Impact of a Food-Assisted Integrated Health and
Nutrition Program in Burundi on Maternal and Child
Nutrition and on Child Development Outcomes.
M. Ruel. Intl. Food Policy Res. Inst.
The Impact of a Food-Assisted Integrated Health and
Nutrition Program in Guatemala on Maternal and
Child Nutrition and on Child Development Outcomes.
D. Olney. Intl. Food Policy Res. Inst.
Differential Pathways for Linear, Ponderal and Head
Growth in Fetal Life: Implications for Healthy Child
Growth Programs in Low-income Settings. P. Ashorn.
Univ. of Tampere.
Moving from Measured Effects to Human Behavior, Costs
and Policy Choices: Identifying Innovative and Costeffective Products and Delivery Platforms to Address
Undernutrition. S. Vosti. Univ. of California, Davis.
Chaired: A. Thalacker-Mercer
Cochaired: M. Drummond
10:30 415.1
The Relationship between Dietary Protein
Intake Distribution and Lean Mass Loss in Free-Living Older
Adults: Effect of Sex and Total Protein Intake. S. Farsijani,
J.A. Morais, H. Payette, P. Gaudreau, B. Shatenstein, K.
Gray-Donald, S. Chevalier. McGill Univ., Univ. of Sherbrooke,
CHUMRC, Montreal and Univ. of Montreal.
10:45 415.2
Whey and Pea Protein Influence Energy
Metabolism and Appetite Response to a Greater Extent Than
Beef Protein. B.L. Neumann, L. Cambias, C. Mitchell, E.
Silva, J.I. Baum. Univ. of Arkansas.
11:00 415.3
The Effects of Reduced Protein-Nutrition Bars
with Enhanced Leucine Content on Ratings of Fullness in
Healthy Women. D. Bolster, M. Rahn, A. Kamil, L. Toth, H.
Leidy, M. Blaze, M. Nunez, E. Guo, J. Wang, L. Harkness.
PepsiCo, Barrington, IL and New Haven, CT and Univ.
11:15 415.4
The Effect of Dietary Protein on Bone during
Weight Loss: A Meta-analysis and Systematic Review. C.S.
Wright, J. Li, W.W. Campbell. Purdue Univ.
11:30 415.5
Effects of Increased Dietary Protein on Daily
Appetite Control, Satiety, and Free-Living Ad Libitum Food
Intake during Acute Energy Restriction in Healthy, Overweight
Women. J.A. Gwin. Univ. of Missouri-Columbia.
11:45 415.6
Higher Protein Intake Improves Sleep and
Blood Pressure, and Influences the Relation between Changes
in Blood Pressure and Sleep during Energy Restriction in
Middle-Aged Overweight and Obese Adults. J. Zhou, J.E. Kim,
W.W. Campbell. Purdue Univ.
TUESDAYNUTRITION
12:00 415.7
Protein Oxidation as a Relevant Factor
Determining Protein Status in Humans. G. Reckman, M.
Priebe, R. Vonk. Univ. Med. Ctr. Groningen, Netherlands.
12:15 415.8
General Control Nonderepressible 2 Kinase
Regulates Body Composition and Antioxidant Defenses during
Dietary Methionine Restriction. A.P. Pettit, A. Bargoud, E.T.
Mirek, T.G. Anthony. Rutgers Univ.-New Brunswick.
416. DBC: PROBIOTICS, GUT MICROBIOTA, AND
GUT HEALTH
Minisymposium
10:30 416.1
Dietary Small RNA Modulation of Gut
Microbiota Composition: In Silico and In Vitro Analyses. H.
Huang, C. Davis, L. Yu, T.T.Y. Wang. USDA, Beltsville, MD,
ODS, NIH and Univ. of Maryland College Park.
10:45 416.2
High-Calorie Diet Induced Chronic Colonic
Inflammation: A Human-Relevant Porcine Model to Assess
Whole Food Approach to Reduce Colon Cancer Risk. J.
Vanamala, A. Sido, E. Eriksson, S.W. Kim, V. Bhat, S.
Radhakrishnan, L. Reddivari. Penn State, Penn State Col. of
Med., Lund Univ., Sweden, North Carolina State Univ., Agilent
Technols., Wilmington, DE and Res. Diets, New Brunswick, NJ.
11:00 416.3
Soluble
Mediators
from
lLactobacillus
rhamnosus GG Reduce Intestinal Permeability and Bacterial
Translocation in a Rat Model of Short Bowel Syndrome Model.
J. Wu, L. Qian, Y. Zhong, G. Gross, E. van Tol, T. Lambers,
W. Cai. Xin Hua Hosp. Affil. to Shanghai Jiaotong Univ. Sch.
of Med., Shanghai Inst. for Pediat. Res. and Mead Johnson
Pediat. Nutr. Inst.,Shanghai and Nijmegen.
11:15 416.4
Expression of MicroRNA-148a and Its Target
Gene EPAS1 (Endothelial Pas Domain-Containing Protein
1) in Intestinal Cells in Response to Bifidobacterium bifidum
MIMBb75. A. Taibi, E.M. Comelli, N. Singh, J. Chen, S.
Guglielmetti. Univ. of Toronto, Ctr. for Child Nutr. and Hlth.,
Toronto and Univ. of Milan.
11:30 416.5
The Impact of Limonin on Gut Microbiota.
M. Gu, J. Sun, C. Qi, K.X. Cai, T. Goulette, Y.M. Song, M.X.
You, D. Sela, H. Xiao. Univ. of Massachusetts Amherst and
Jiangnan Univ., China.
11:45 416.6
Impact of Cranberry on Gut Microbiota in a
Colon Carcinogenesis Mouse Model. X. Cai, J. Sun, C. Qi, M.
Gu, T. Goulette, X. Wu, M. Song, X. You, D. Sela, C. Neto, H.
Xiao. Univ. of Massachusetts Amherst, Jiangnan Univ., China
and Univ. of Massachusetts Dartmouth.
12:00 416.7
Dietary Enrichment with Blueberry and/or
Probiotics Does Not Alter Blood Pressure Variability Compared
to Control Diet in Hypertensive Rats. C. Blanton, Z. He, K.T.
Gottschall-Pass, M.I. Sweeney. Idaho State Univ. and Univ. of
Prince Edward Island, Canada.
12:15 416.8
Dietary Red Raspberries Supplementation
Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis.
S. Bibi, Y. Kang, M. Du, Y. Xue, M-J. Zhu. Washington State
Univ. Pullman.
417. NUTRITIONAL EPIDEMIOLOGY: NUTRITION
AND CHRONIC DISEASE EPIDEMIOLOGY
Minisymposium
Chaired: S. Sahni
Cochaired: N. Ollberding
10:30 417.1
Impact of Body Mass Index and Metabolic
Health Status on All-Cause Mortality Risk among Older Adults.
F.W. Cheng, X. Gao, D.C. Mitchell, C. Wood, C. Still, G.L.
Jensen. Penn State and Geisinger Obesity Inst., Danville, PA.
10:45 417.2
Higher Adherence to the Mediterranean Diet
Score, but Not Other Diet Quality Scores, Is Associated with a
Favorable Longitudinal Cardiometabolic Profile in the Boston
Puerto Rican Health Study. J. Mattei, M. Sotos-Prieto, S.E.
Noel, K.L. Tucker. Harvard T.H. Chan Sch. of Publ. Hlth. and
Univ. of Massachusetts Lowell.
11:00 417.3
Vitamin K Consumption Is Associated with Left
Ventricular Structure and Function in Adolescents. J. Nguyen,
M.E. Fain, C.L. Davis, G.K. Kapuku, B. Gutin, N.K. Pollock.
Georgia Regents Univ., Med. Col. of Georgia, Georgia Prevent.
Inst. and Univ. of North Carolina at Chapel Hill.
11:15 417.4
Correlation of Adolescent Caffeine Intake with
Blood Pressure in Adolescence and Adulthood. E. Estrada,
E.M. Urbina, S.R. Daniels, J.G. Woo. Univ. of California, Davis,
Cincinnati Children’s Hosp. Med. Ctr. and Univ. of Colorado
Sch. of Med.
11:30 417.5
Breastfeeding as a Potential Factor Related
to Preservation of Insulin Secretion in Youth with Recently
Diagnosed Type 2 Diabetes: The Search Nutrition Ancillary
Study. T.L. Crume, J. Crandell, A.P. Lamichhane, D. Dabelea,
J.A. Tooze, A. Liese, L. Dolan, J.M. Lawrence, C. Pihoker, E.J.
Mayer-Davis. Colorado Sch. of Publ. Hlth., Univ. of Colorado
Anschutz Med. Campus, Univ. of North Carolina at Chapel Hill,
LEAD Ctr., Aurora, Wake Forest Univ., Univ. of South Carolina,
Cincinnati Children’s Hosp. Med. Ctr., Kaiser Permanente So.
California, Pasadena and Seattle Children’s Hosp.
11:45 417.6
Nut Intake, Prospective Weight Change, and
Obesity Risk: The Adventist Health Study-2. S.S. El-Amari, J.I.
Lloren, J. Sabate. Loma Linda Univ. Sch. of Publ. Hlth.
12:00 417.7
Dietary Carbohydrate Intake, Glycemic Index
and Glycemic Load in Relation to Adiposity-Related Cancer
Risk: Results from the Framingham Offspring Cohort (19912013). N. Makarem, Y. Lin, E.V. Bandera, P. Jacques,
N. Parekh. Col. of Publ. Hlth., NYU, Rutgers Cancer Inst. of
NJ, Rutgers Univ. and USDA at Tufts Univ.
12:15 417.8
A Review and Meta-analysis of Prospective
Studies of Red and Processed Meat, Meat Cooking Methods,
Heme Iron, Heterocyclic Amines and Prostate Cancer. L.C.
Bylsma, D. Alexander. EpidStat Inst., Ann Arbor.
123
T
U
E
NUTRITIONTUESDAY
DIET AND/OR EXERCISE REGULATION OF
FOOD INTAKE
Minisymposium
Minisymposium
(Sponsored by: Medical Nutrition Council)
(Cosponsored by: Obesity RIS)
Chaired: C.W. Bales
Chaired: N. Bellissimo
Cochaired: B. Burton-Freeman
10:30 418.1
Mechanisms of Appetite Suppression after High
Intensity Exercise in Lean and Obese Boys. S. Hunschede, A.
Schwartz, R. Kubant, R. Akilen, S. Thomas, G.H. Anderson.
Univ. of Toronto Fac. of Med. and Fac. of Kinesiol.
10:45 418.2
The Relative Reinforcing Value of Snack
Foods in Response to Consumption of Sugar- or Non-nutritiveSweetened Beverages. S.L. Casperson, L. Johnson, J.N.
Roemmich. USDA, Grand Forks.
11:00 418.3
Changes in Hunger and Fullness in Relation to
Gut Peptides Before and After 8 Weeks of Alternate Day Fasting.
K.A. Varady, K.K. Hoddy, C.M. Kroeger, J.F. Trepanowski, S.
Bhutani, A. Barnosky. Univ. of Illinois at Chicago.
11:15 418.4
FTO Genotype and Weight Status among
Children: Assessing Mediating and Independent Effects of
Child Eating Behaviors. J.A. Emond, A. Tovar, R. Lansigan, Z.
Li, D. Gilbert-Diamond. Geisel Sch. of Med. at Dartmouth and
Univ. of Rhode Island.
11:30 418.5
Impact of Imposed Exercise on Children’s Ad
Libitum Energy Intake. S.N. Fearnbach, T.D. Masterson, H.A.
Schlechter, D.S. Downs, D. Thivel, K.L. Keller. Penn State
and Clermont Auvergne Univ., France
11:45 418.6
Menstrual Cycle Hormones, Food Intake, and
Cravings. S. Krishnan, R. Tryon, L.C. Welch, W.F. Horn, N.L.
Keim. Univ. of California, Davis and USDA, Davis.
12:00 418.7
Effects of Dietary Protein and Fiber at Breakfast
on Postprandial Appetite, Neural Responses to Visual Food
Stimuli, and Ad Libitum Energy Intake at Lunch in Overweight
Adults. R.D. Sayer, A. Amankwaah, G. Tamer; Jr, N. Chen,
A. Wright, J. Tregellas, M. Cornier, D. Kareken, T. Talavage,
M. McCrory, W. Campbell. Weldon Sch. of Biomed. Engin.,
Purdue Univ., Univ. of Colorado Sch. of Med., Anschutz Med.
Campus, Indiana Univ. Sch. of Med. and Georgia State Univ.
12:15 418.8
Comparison of the Effects of a Sweetened
Beverage Intervention on Self-Selected Food Intake. A.M.
Widaman, K.L. Stanhope, G.X. Chen, V.M. Medici, A.A.
Bremer, V. Lee, M.V. Nunez, P.J. Havel, N.L. Keim. Univ. of
California, Davis and USDA, Davis.
124
419. INTERVENTIONS FOR THE TREATMENT
AND PREVENTION OF NUTRITIONRELATED DISEASES
10:30 419.1
Influence of Daily and per Meal Protein Intakes
on Function and Body Composition in Frail, Obese Older
Adults Undergoing Weight Reduction. K.N. Porter Starr,
M.C. Orenduff, S.R. McDonald, C.F. Pieper, H.C. Mulder, K.
Maloney, C.W. Bales. Duke Univ. Med. Ctr. and Durham VA
Med. Ctr.
10:45 419.2
Multipronged Therapeutic Mechanisms of
Chinese Herbal Medicine QHD in the Treatment of NAFLD. Q.
Feng, W. Liu, S.S. Baker, H. Li, S. Meng, Y. Tang, S. Tang,
L. Guan, M. Tsompana, R. Kozielski, R. Zhu, R.D. Baker, J.
Peng, G. Ji, P. Liu, Y. Hu, L. Zhu. Shanghai Univ. of Traditional
Chinese Med., SUNY Buffalo, Ningbo No.2 Hosp. and Tongji
Univ., China.
11:00 419.3
Acute
Orange
Pomace
Consumption
Diminishes Postprandial Glycemic Responses in Healthy Men.
C-Y.O. Chen, J.B. Blumberg. USDA at Tufts Univ.
11:15 419.4
Prebiotic Diet Modulates Gut Microbial
Composition and Metabolic Functions in Metabolic Syndrome
Patients: Follow-Up of a Double Blind, Controlled, Crossover
Intervention. B. Upadhyaya, R. Juenemann, L. McCormack,
A.R. Fardin-Kia, J. Clapper, S. Nichenametla, B. Specker, M.
Dey. South Dakota State Univ. and USDA, College Park, MD.
11:30 419.5
Parents of Preschoolers: Weight-Related
Cognitions and Behaviors. J.T. Martin-Biggers, V. Quick, G.
Povis-Alleman, N. Hongu, J. Worobey, C. Byrd-Bredbenner.
Rutgers Univ. and Univ. of Arizona.
11:45 419.6
Prospective Association of Fasting Blood
Glucose Levels with Risk of Incident Stroke among Hypertensive
Patients in China: Impact of Folic-Acid Intervention. R. Xu, X.
Kong, B. Xu, M. Ji, Y. Zhang, B. Wang, F.F. Hou, J. Ge, Y. Huo,
J. Li. River Hill H.S., Clarksville, MD, Peking Univ. First Hosp.,
Beijing, Zhongshan Hosp., Fudan Univ., China, Nanfang Hosp.,
So. Med. Univ., China.
12:00 419.7
Camel Milk and Nigella sativa Oil Improve
Liver Biomarkers among Children with Viral Hepatitis. M.S.
Ismail, A.E-S. El- Adawi, O.M. Nassar. Menoufia Univ., Egypt
and Univ. of Dammam, Saudi Arabia.
12:15 419.8
Three Doses of Vitamin D on Insulin Resistance
and Osteocalcin Measures in Older Women. L.C. Pop, S.H.
Schneider, D. Sukumar, Y. Schlussel, S.A. Shapses.
Rutgers Univ., Rutgers-Robert Wood Johnson Med. Sch. and
Drexel Univ.
TUESDAYNUTRITION
420. AGING: NUTRITION AND
GASTROINTESTINAL HEALTH
Minisymposium
Chaired: B.H. Arjmandi
Cochaired: M.G. Miller
10:30 420.1
Food Items That Trigger a Symptom in
Functional Gastrointestinal Disorders. D. Dikmen, Z. Göktaş,
A. Demir, Ö. Öztürk, E. Kahramanoğlu Aksoy, H. Köklü, Y.
Tuna, M. Kekilli, H. Korkmaz, B. Yılmaz, M. Asıl, G. Köklü, S.
Köklü. Hacettepe Univ., Hacettepe Univ. Fac. of Med., Akdeniz
Univ. Fac. of Med., Ankara Educ. and Res. Hosp., Selçuk Univ.
Fac. of Med. and Necmettin Erbakan Univ. Meram Fac. of
Med., Turkey.
10:45 420.2
Black Berry Polyphenol Reduce Nox1 Function
to Inhibit Senescence in Vascular Smooth Muscle Cells. J.
Huang, R. Feresin, Y. Zhao, S. Pourafshar, B.H. Arjmandi, G.
Salazar. Florida State Univ. and Univ. of Arkansas for Med. Sci.
11:00 420.3
Capsaicin Inhibits Methionine Cotransport in
Rat Intestinal Epithelial Cells. J. Talukder, C. Cameron Hill,
A. Jaima, J. Santiz-Lopez. LeMoyne-Owen Col., TN and
Boston Univ.
11:15 420.4
Effect of Dietary Carboxymethyllysine on
Glucose and Insulin Sensitivity, Cecal Fatty Acids and the
Plasma Metabolome in Mice Fed the Total Western Diet. R.E.
Ward, S. Xiao, M-C. Michalski, A. Geloen, K. Hintze. Utah
State Univ. and INSA-Lyon, France.
11:30 420.5
A High Flavonoid Diet Reduces Gut
Permeability, Short Chain Fatty Acid Production and Decreases
Gut Inflammation in Overweight and Obese Men and Women.
R.E. Ward, J. Bergerson, N. Hergert, J. Hergert, S. Aguilar,
A. Khan, S. Kung, M. Lefevre. Utah State Univ.
11:45 420.6
Serum 25-Hydroxy D3 Levels in Nonalcoholic
Fatty Liver Disease. Z. Goktas, S. Galyean, D. Syn, S. Koklu,
S. Wang, M. Boylan, D. Dikmen, B. Uyar. Hacettepe Univ.,
Turkey, Texas Tech Univ. and Gazi Univ., Turkey.
12:00 420.7
Mango (Mangifera indica L.) in the Promotion
of Intestinal Regularity and Decreases Inflammation in Human
Subjects with Constipation. S.U. Mertens-Talcott, H. Kim, S.T.
Talcott, V.P. Venancio. Texas A&M Univ.
12:15 420.8
Lactose Intolerance, Calcium, Vitamin D and
Parathyroid Hormone Levels in Type 2 Diabetic Patients.
S. Rana, A. Malik, S.K. Bhadada, N. Sachdeva, R.K.
Morya, G. Sharma. Post Grad. Inst. of Med. Educ. and Res.,
Chandigarh, India.
421. PULSES, NUTRITION AND HEALTH
Minisymposium
Chaired: C. Marinangeli
10:30 421.1
Effect of Dietary Pulse Consumption on Blood
Pressure. S.E. Stewart, C.A. Ireland, C. de Souza, R.J. de
Souza, S. Mitchell, L.S. Augustin, R.G. Josse, L.A. Leiter,
C.W.C. Kendall, J.L. Sievenpiper, D.J.A. Jenkins. Fac. of
Med., Univ. of Toronto, St. Michael’s Hosp., Toronto, McMaster
Univ. and Univ. of Saskatchewan Col. of Pharm. and Nutr.
10:45 421.2
Navy Bean Supplementation in Obesity
Increases Akkermansia muciniphila Abundance and Attenuates
Obesity-Related Impairments in Gut Barrier Function. J.M.
Monk, D. Lepp, W. Wu, D. Graf, A.L. Hutchinson, L.E.
Robinson, K.A. Power. Univ. of Guelph and Agr. and AgriFood Canada, Guelph.
11:00 421.3
White Tepary Bean Shows Higher In Vitro
Iron Bioavailability than Brown Tepary or Common Bean. A.E.
Bries, M.B. Reddy, D.M. Winham. Iowa State Univ.
11:15 421.4
Studies of Cream Seeded Carioca Beans
(Phaseolus vulgaris L.) from a Rwandan Efficacy Trial: In
Vitro and In Vivo (Including Effects on Intestinal Microbiome)
Screening Tools Reflect Human Studies and Predict Beneficial
Results from Iron Biofortified Beans. E. Tako, R.P. Glahn.
USDA, Cornell Univ.
11:30 421.5
Effect of Dietary Pulses in a Low Glycemic Index
Diet on Renal Function in Participants with Type 2 Diabetes
Mellitus. S. Blanco Mejia, C. Ireland, L.S.A. Augustin, E.
Vidgen, C.W.C. Kendall, S. Mitchell, S. Sahye-Pudaruth,
L. Chiavaroli, A. Mirrahimi, B. Bashyam, J. Coveney, R.J.
de Souza, J.L. Sievenpiper, L.A. Leiter, R.G. Josse, T.M.S.
Wolever, V.V.V. Vuksan, P.B. Pencharz, D.J.A. Jenkins. St.
Michael’s Hosp., Univ. of Toronto, Univ. of Saskatchewan,
Queen’s Univ., Canada, McMaster Univ., Canada and Sick
Kids Hosp., Toronto.
11:45 421.6
Determination of the In Vivo and In Vitro
Protein Quality of Pulse Protein Concentrates and Isolates.
M.G. Nosworthy, J. Neufeld, J.D. House. Univ. of Manitoba.
12:00 421.7
The Effect of a Low-Glycemic Index PulseBased Diet on Performance and Body Composition in Soccer
Players. E. Mizelman, P. Chilibeck, A. Hanifi, M. Kaviani, E.
Brenna, G. Zello. Col. of Kinesiol and Col. of Pharm. and Nutr.,
Univ. of Saskatchewan.
12:15 421.8
Toward Closing the Dietary Fiber Gap:
Candidate Genes Associated with Dietary Fiber Content
in Common Bean. M.A. Brick, H.J. Thompson. Colorado
State Univ.
COMMUNITY AND PUBLIC HEALTH
NUTRITION INTERVENTIONS
Minisymposium
Nutrition RIS)
Chaired: G. George
Cochaired: J. Martin-Biggers
10:30 422.1
B’More Healthy Communities for Kids, a
Multilevel Obesity Prevention Program for African American
Children: Wave 1 Process and Impact Results. J. Gittelsohn,
A. Trude, C. Shipley, M.J. Mejia Ruiz, T. Schwendler, T.
Eckmann, I. Loh, N. Rapp. Johns Hopkins Bloomberg Sch. of
Publ. Hlth.
10:45 422.2
HomeStyles: Recruitment Strategies for a
Childhood Obesity Prevention Randomized Controlled Trial.
J.T. Martin-Biggers, C. Delaney, M. Koenings, C. ByrdBredbenner. Rutgers Univ.
125
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NUTRITIONTUESDAY
11:00 422.3
Impact of Folic-Acid Intervention and
MTHFRC677T Gene Polymorphism on All-Cause Mortality
Associated with Elevated Serum Homocysteine Levels in
Chinese Adults with Hypertension. B. Xu, X. Kong, R. Xu,
M. Zhao, Y. Song, C. Zhang, T. Yu, L. Liu, F. Fan, Y. Zhang,
X. Qin, G. Tang, B. Wang, F.F. Hou, Y. Huo, J. Li. River Hill
High Sch., Clarksville, MD, Peking Univ. First Hosp., Beijing,
Nanfang Hosp., Southern Med. Univ., Guangzhou and Anhui
Med. Univ., China.
11:15 422.4
Longitudinal Quality of Life Improvement after
a Family-Based Lifestyle Intervention in Youth with Obesity.
S.R. Engebretsen, K. Briggs Early, R. Sorrells, J.P. YiFrazier, M. Sanchez, K. Gottlieb, B.L. Gonzalez, B. Lopez.
Pacific Northwest Univ. of Hlth. Sci., Seattle Children’s Res.
Inst. and Yakima Valley Mem. Hosp., WA.
11:30 422.5
Food Label Use Improves Dietary Quality and
Mediates Improved Glycemic Control in Latinos with Type
2 Diabetes: The DIALBEST Trial. G. Kollannoor Samuel,
F.M. Shebl, S. Segura-Pérez, J. Chhabra, S. Vega-López,
R. Pérez-Escamilla. Yale Sch. of Publ. Hlth., Hispanic Hlth.
Council, Harford, CT, Hartford Hosp. and Arizona State Univ.
11:45 422.6
Understanding Acceptance, Compliance,
and Utilization of Micronutrient Powder in Northern Nigeria –
Informing Implementation through Formative Research. S.R.
Kodish, C.L. Ejembi, T. Osunkentan, A. Imohe, P. Mathema.
Johns Hopkins Bloomberg Sch. of Publ. Hlth., Ahmadu Bello
Univ., Nigeria and UNICEF Nigeria.
12:00 422.7
Cross-Country Comparison of the Acceptability
of a Social Support Behavior Change Strategy to Improve
Adherence to Antenatal Calcium and Iron-Folic Acid
Supplementation. S. Martin, M. Omotayo, G. Chapleau, R.
Stoltzfus, Z. Birhanu, S. Ortolano, K. Dickin. Cornell Univ.
and Jimma Univ., Ethiopia.
12:15 422.8
The Impact of Nutrition Label Usage on Food
Selection and Consumption in a University Dining Setting. M.J.
Christoph, B.D. Ellison. Univ. of Illinois at Urbana-Champaign.
11:15 423.3
Measurement of Epigallocatechin Gallate
(EGCG) and Caffeine Content of 32 Green Tea Dietary
Supplements for the Dietary Supplement Ingredient Database.
K.W. Andrews, P.T. Dang, S. Savarala, P.A. Gusev, F. Han,
P.R. Pehrsson, J.M. Harnly, P. Chen, Y. Zhao, J.T. Dwyer,
J.M. Betz, L.G. Saldanha, R.B. Costello. USDA, Beltsville and
ODS, NIH.
11:30 423.4
Are Chromium Supplements Efficacious
for Glycemic Control in Type 2 Diabetes? J.T. Dwyer, R.B.
Costello, R.L. Bailey, E. Wambogo. ODS, NIH.
11:45 423.5
Do Cinnamon Supplements Have a Role
in Glycemic Control in Type 2 Diabetes? R.B. Costello, J.T.
Dwyer, L.G. Saldanha, R.L. Bailey, E. Wambogo. ODS, NIH
and Purdue Univ.
12:00 423.6
Menaquinone-7 Supplementation Improves
Lipid Profile in Obese African-American Children: A Randomized
Controlled Trial. N.K. Pollock, J. Nguyen, M.E. Fain, B.A.
Gower, R. Bassali, C.L. Davis. Georgia Regents Univ., Med.
Col. of Georgia and Univ. of Alabama at Birmingham.
424. W.O. ATWATER MEMORIAL LECTURE
Award Lecture
Tue. 12:45 pm—San Diego Convention Center,
Ballroom 20D
12:45Introduction.
1:00
How Can Nutrition Scientists Help Reverse the Obesity
Epidemic? S.B. Roberts. Tufts Univ. Sch. of Med.
425. AFRICAN GRADUATE NUTRITION
STUDENTS NETWORK
International Forum
(Organized and Sponsored by: the African Graduate
Nutrition Students Network)
423. NUTRITIONAL EPIDEMIOLOGY: RESEARCH
WITH DIETARY SUPPLEMENTS AND
BIOACTIVE COMPOUNDS
Minisymposium
Chaired: N. Ahluwalia
Cochaired: P.M. Coates
10:30
Introduction.
10:45 423.1
Comparison of Polyphenol Intakes in Relation
to Dietary Patterns and Food Sources in the Adventist Health
Study-2 Cohort. N. Burkholder-Cooley, S. Rajaram, E.
Haddad, G. Fraser, K. Jaceldo-Siegl. Loma Linda Univ.
11:00 423.2
Daily Patterns and Factors Including Gender,
Race and Occupation Associated with Caffeine Intake among
US Adults: NHANES 2007-2012. H.R. Lieberman, S. Agarwal,
V.L. Fulgoni III. U.S. Army Res. Inst. of Envrn. Med., Natick,
MA, NutriSci. LLC, East Norriton, PA, Oak Ridge Inst. for Sci.
& Educ., Belcamp, MD, Nutr. Impact LLC, Battle Creek, MI and
Henry M. Jackson Fndn., Bethesda, MD.
126
Tue. 1:30 pm—San Diego Convention Center, Room 28DE
Chaired: J. Ashong
The overall goal of this session is to raise awareness of the
African Graduate Nutrition Students Network (AGSNet) – the
history of the network, its goals and aspirations. The emphasis
will be on the unique approach and the strategic position of the
network to contribute to tackling the malnutrition menace on the
African continent. The session will also highlight the importance
of the strategic partnership between ASN and the AGSNet and its
implications for the future of the network.
1:30
Background to AGSNet formation: The Road Up to Now.
N. Mbuya. World Bank.
1:45
Partnerships: ASN and AGSNet. P. Stover. Cornell Univ.
2:00
AGSNet in the Future. B. Zarhari Abu. Texas Tech Univ.
2:15Discussion.
TUESDAYNUTRITION
426. ARCHITECTURE OF HEALTHY MUSCLES:
THE INTERPLAY BETWEEN EXERCISE AND
NUTRITION ON MUSCLE METABOLISM
Symposium
Tue. 3:00 pm—San Diego Convention Center, Room 31ABC
Chaired: B.B. Rasmussen
Cochaired: T.A. Davis
3:00
3:30
4:00
4:30
Aged Muscle Protein Metabolism Responses to Physical
Inactivity and Rehabilitation. M. Drummond. Univ.
of Utah.
Identification of Nutritional Ingredients that Reduce Agerelated Muscle Weakness and Atrophy. C. Adams.
Univ. of Iowa Carver Col. of Med.
Preserving Healthy Muscle During Weight Loss.
B. Mittendorfer. Washington Univ. in St. Louis.
Muscle Health During Prolonged Resistance Training
and Protein Supplementation. B. Rasmussen. Univ.
of Texas Med. Br.
427. INNOVATIVE TECHNIQUES TO EVALUATING
BEHAVIORAL NUTRITION INTERVENTIONS IN
THE COMMUNITY
Symposium
Tue. 3:00 pm—San Diego Convention Center, Room 32AB
Cochaired: R.E. Scherr
3:00
3:15
3:40
4:05
4:30
Current Limitations and Future Opportunities in
Evaluating Behavioral Nutrition Interventions in
the Community. A. Mobley, R. Scherr. Univ. of
Connecticut, Univ. of California, Davis.
An Inside Out View of Responsiveness to Nutrition
Education: What Can Functional MRI Tell Us About
the Brain? K. Laugero. USDA ARS Western Human
Nutr. Res. Ctr.
I’ll Believe It When I See It: Results of Eye-Tracking
Nutrition Research. D. Graham. Colorado State Univ.
Smartphone Biosensors: New Tools for Nutrition and
Health Diagnostics. B. Cunningham. Univ. of Illinois
at Urbana-Champaign.
The Special Case of Fruit and Vegetables: Assessing
Community Intervention Effectiveness Using Skin
Carotenoid Status. L. Jahns. USDA ARS Grand
Forks Human Nutrition Res. Ctr.
428. DBC: DIETARY BIOACTIVE COMPONENTS AND
OBESITY AND METABOLIC SYNDROME
Minisymposium
Chaired: J.D. Lambert
Cochaired: K-H. Kim
3:00 428.1
Inclusion of 100% Concord Grape Juice
Reduces Glucose Release following In Vitro Digestion of
a Model Carbohydrate Rich Meal. S.E. Moser, J. Lim, J.D.
Whiteman, B. Hamaker, M. Ferruzzi. Purdue Univ.
3:15 428.2
Insulin and Cinnamon Polyphenol Extract
Regulated Diacylglycerol Acyltransferase and Tristetraprolin
Gene Expression in Cultured Mouse Adipocytes and
Macrophages. H. Cao, R.A. Anderson. USDA, New Orleans
and Beltsville, MD.
3:30 428.3
Mice Fed High-Fat Obesigenic Diets with Walnut
Plus Other Whole Foods Demonstrate Metabolic Improvement
and Changes in Gene Expression and Metabolomic Patterns.
N.F. Shay, T. Luo, O. Miranda, A. Adamson. Oregon State Univ.
3:45 428.4
Effect of Decaffeinated Green and Black Tea
Extracts on Energy Metabolism in Mice Fed a High Fat/High
Sucrose/Western Diet. S.M. Henning, J. Yang, E.M. Grojean,
R-P. Lee, M. Hsu, D. Heber, Z. Li. UCLA.
4:00 428.5
Cocoa
Increases
Postprandial
GLP-1
Response in Adults with Impaired Glucose Tolerance. K. Strat,
B.M. Davy, M.W. Hulver, K.P. Davy, A.P. Neilson. Virginia Tech.
4:15 428.6
The Hypoglycaemic Potential of AntioxidantRich Food Extracts. L. Chepulis. Waiariki Inst. of Technol.,
New Zealand.
4:30 428.7
Ingested Capsaicinoids Can Prevent Low-Fat/
High-Carbohydrate Diet and High-Fat Diet-Induced Obesity by
Regulating the Expression of Genes for Metabolism. K. Sahin,
C. Orhan, M.Tuzcu, N. Sahin, O. Ozdemir, V. Juturu. Firat Univ.,
Turkey and OmniActive Hlth. Technols. Inc., Morristown, NJ.
4:45 428.8
Effects of Selenium in Comparison to Exendin-4
on the Expression of GLP-1R, IRS-1 and Preproinsulin in the
Pancreas of Diabetic Rats. S. Rizk, G. Barakat, M. Moustafa,
I. Khalifeh, M.H. Hodroj, A. Bikhazi. Lebanese American Univ.
and American Univ. of Beirut.
429. NUTRITIONAL EPIDEMIOLOGY: ADVANCING
NUTRITIONAL EPIDEMIOLOGY WITH PUBLIC
USE AND COMMERCIAL DATA SETS
Minisymposium
Chaired: J. Mattei
Cochaired: K. Kordas
3:00 429.1
Total and Added Sugar Intakes among 4-13
Year Old Children in China, Mexico, and the U.S. M.C. Afeiche,
B.N. Shaheen Koyratty, D. Wang, E. Jacquier, A.L. Eldridge,
K-A. Lê. Nestlé Res. Ctr., Lausanne.
127
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NUTRITIONTUESDAY
3:15 429.2
Nudging Food Purchases towards Health:
Trends in Price Promotions and Nutrient Claims on Packaged
Foods and Beverages. L.S. Taillie, S.W. Ng, Y. Xue, M.
Harding. Univ. of North Carolina at Chapel Hill and Duke Univ.
Sanford Sch. of Publ. Policy.
3:30 429.3
Calibrating Self-Reported MVPA Strengthens
Relationship with Metabolic Syndrome. C. Ford, S. Chang, S.
Grabich, L. Strong, M. Mendez. Univ. of Texas MD Anderson
Cancer Ctr., EPA, Chapel Hill and Univ. of North Carolina at
Chapel Hill.
3:45 429.4
Dietary Intake Assessment of Snacking among
Children in China and U.S. D. Wang, A.L. Eldridge. Nestlé
Res. Ctr., Lausanne.
4:00 429.5
Dietary Flavonoid Intake Is Negatively
Associated with Anthropometric Risk Factors for Chronic
Disease in Some Population Subgroups but Not Others:
Results from What We Eat in America, NHANES 2007-2010.
R.S. Sebastian, C. Wilkinson Enns, J.D. Goldman, L.C.
Steinfeldt, A.J. Moshfegh. USDA, Beltsville, MD.
4:15 429.6
Has the Sodium Content of U.S. Households’
Packaged Food and Beverage Purchases Improved in the
Past 15 Years? J.M. Poti, E. Dunford, B.M. Popkin. Univ. of
North Carolina at Chapel Hill.
4:30 429.7
Assessing the Public’s Comprehension of
Dietary Guidelines: Perception of Diet Quality Is Inversely
Associated with Dietary ED in U.S. Adults. J.A. Vernarelli, R.
Nouri. Fairfield Univ.
4:45 429.8
Socioeconomic Disparities in Dietary Intake
and Food Purchasing of Foods and Beverages of Varying
Healthfulness in Mexico. N. Lopez-Olmedo, L.P. Smith Taillie,
B.M. Popkin. Univ. of North Carolina at Chapel Hill.
PROTEIN AND AMINO ACID METABOLISM
Minisymposium
Chaired: E-K. Samer
3:00 430.1
Energy Deficiency, but Not Aerobic Exercise,
Is Associated with Increased Stable Nitrogen Isotope Ratio
of Urinary Urea. K. Koehler, U. Flenker, W. Schaenzer, F.
Huelsemann. Univ. of Nebraska-Lincoln and German Sport
Univ., Cologne.
3:15 430.2
Intermittent Leucine Pulses during Continuous
Feeding Alters Novel Components Involved in Skeletal Muscle
Growth of Neonatal Pigs. A. Suryawan, C. Boutry, R. Manjarín,
A. Cánovas, A. Islas-Trejo, J.F. Medrano, H. Nguyen, M.L.
Fiorotto, T.A. Davis. USDA and Baylor Col. of Med., Cal Poly
State Univ., San Luis Obispo, Univ. of California, Davis and
Univ. of Guelph, Canada.
3:30 430.3
Effects of Inflammation on Arginine Transport
and Metabolism in Human Primary Myotubes. D. Gupta,
E.S. Riddle, J.E. Blum, H. Roman, A. Thalacker-Mercer.
Cornell Univ.
3:45 430.4
Depletion of Programmed Cell Death Protein 4
(PDCD4), an mTORC1/S6K1 Substrate, Attenuates Proteolysis
in L6 Myotubes. O.J. Adegoke, S. Abou Sawan, H. Cho. York
Univ., Canada.
128
4:00 430.5
Genes Associated with Amino Acid Sensing in
Human Skeletal Muscle Are Altered by Amino Acid Availability
and Acute Lysosomal Perturbation. T.G. Graber, M.S. Borack,
P.T. Reidy, E. Volpi, B.B. Rasmussen. Univ. of Texas
Med. Branch.
4:15 430.6
Citrulline Is a More Efficient Supplement Than
Arginine to Increase Systemic Arginine Availability in Mice. U.
Agarwal, I.C. Didelija, J.C. Marini. Baylor Col. of Med.
4:30 430.7
Leucine in the Presence of Inflammation Alters
BCAA Metabolism in Human Myotubes. E.S. Riddle, H. Roman,
M. Ahsan, H. Shin, A. Thalacker-Mercer. Cornell Univ.
4:45 430.8
Genetic Background and Sex Determine
Citrulline and De Novo Arginine Production in Mice. J.C. Marini,
U. Agarwal, I.C. Didelija. Baylor Col. of Med.
431. NUTRIENT-GENE INTERACTION: CHRONIC
DISEASE, OBESITY AND INFLAMMATION
Minisymposium
Nutrient-Gene Interaction RIS
Tue. 3:00 pm—San Diego Convention Center, Room 29D
Chaired: J.I. Baum
3:00 431.1
Differential DNA Methylation between Obese
and Normal Weight Women in CD4+ and CD8+ T Cells, and
CD16+ Neutrophils. N.M. Hohos, A.K. Smith, V. Kilaru, H.J.
Park, D.B. Hausman, L.B. Bailey, R.D. Lewis, R.B. Meagher.
Univ. of Georgia and Emory Univ.
3:15 431.2
Lipoprotein Lipase Modulates Bone Marrow
Myeloid Cell Proliferation by Affecting Colony-Stimulating
Factor Levels and Recruitment. C.L. Chang, I.J. Goldberg,
R.J. Deckelbaum. Columbia Univ. and NYU.
3:30 431.3
Genetic Ablation of TNF-α Attenuates High Fat
Diet-Induced Obesity Potentially via Diminishing Wnt-Signaling
and Determinant Genes of Adipogenesis. J. Li, A-L. Frederick,
Y-C. Kim, R.J. Wood, Z. Liu. Sch. of Publ. Hlth. and Hlth. Sci.,
Univ. of Massachusetts Amherst and USDA at Tufts Univ.
3:45 431.4
Detection of Intimal Macrophages in
Atherosclerotic Lesions Using Biocompatible CD36-Targeted
Ligand Containing Nanoparticle. C.S. Dhanasekara, J. Zhang,
S. Nie, S. Wang. Texas Tech Univ.
4:00 431.5
Congenic Mice Confirmed QTL Linked
to Obesity and Hyperlipidemia on Chromosome 1 in the
TALLYHO Mouse. J.K. Parkman, X. Mao, K. Dillon, J.H. Kim.
Marshall Univ.
4:15 431.6
Oral Corticosterone Administration Reduces
Insulitis but Promotes Insulin Resistance and Hyperglycemia
in Male Non-obese Diabetic Mice. S.J. Burke, A.E. Eder, K.M.
Regal, M.D. Karlstad, D.H. Burk, R.C. Noland, J. Collier.
Pennington Biomed. Res. Ctr., Baton Rouge and Univ. of
4:30 431.7
Exacerbation of NAFLD in Both HFD-Fed Mice
and MCD-Fed Mice by Adenosine 2A Receptor Deficiency. Y.
Cai, J. Zheng, X. Guo, H. Li, Y. Pei, R. Botchlett, S-L. Woo, M.
Liu, G. Chen, Y. Huo, C. Wu. Tongji Col. of Med., China, Texas
A&M Univ. and Georgia Regents Univ.
4:45 431.8
Lipids and Cholesterol-Lowering Activity of
Red Cabbage Microgreens. X. Jiang, H. Huang, Z. Xiao, L. Yu,
Q. Pham, L. Yu, Y. Luo, T.T.Y. Wang. Univ. of Maryland College
Park and USDA, Beltsville, MD.
TUESDAYNUTRITION
432. GLOBAL NUTRITION: LINEAR GROWTH,
GROWTH FAILURE, AND ANTHROPOMETRY
Minisymposium
COMMUNITY AND PUBLIC HEALTH
APPROACHES TO OBESITY PREVENTION
Minisymposium
Nutrition RIS)
Chaired: A.D. Stein
Cochaired: N. Perumal
3:00 432.1
Protein and Micronutrient Intakes Are
Associated with Child Growth and Morbidity from Infancy to
Adulthood in the Philippines. A. Bhargava. Univ. of Maryland
Sch. of Publ. Policy.
3:15 432.2
A Plasma Proteome Is Associated with
Anthropometric Status in School-Aged Children in Nepal.
S.E. Lee, P. Christian, K. Schulze, R.N. Cole, L.S.F. Wu,
J.D. Yager, J. Groopman, C.P. Stewart, K.P. West; Jr. Johns
Hopkins Bloomberg Sch. of Publ. Hlth., Johns Hopkins Sch. of
Med. and Univ. of California, Davis.
3:30 432.3
Length-for-Age
and
Weight-for-Age
z
Scores at Birth Using the World Health Organization Growth
Standards versus the New INTERGROWTH 21st Newborn Size
Standards. N. Perumal, J. Shi, D. Bassani, A. Al-Mahmud,
M.M. Islam, T. Ahmad, D. Roth. Dalla Lana Sch. of Publ. Hlth.,
Univ. of Toronto, Hosp. for Sick Children, Toronto and icddr,b,
Dhaka, Bangladesh.
3:45 432.4
An Enteropathy Score Predicts Subsequent
Length Better Than Lactulose Mannitol Ratio Alone in
Children Enrolled in a Community-Based Randomized Trial of
Complementary Food Supplements in Rural Bangladesh. R.
Campbell, K. Schulze, S. Shaikh, H. Ali, S. Mehra, L. Wu, P.
JiVitA, Bangladesh.
4:00 432.5
Maternal
Docosahexaenoic
Acid
Supplementation Promotes Lean Body Mass in the Preterm
Infant. C.J. Valentine, J. Kleiman, K. Dingess, A. Morrow, L.K.
Rogers. Mead Johnson Nutr., Univ. of Cincinnati, Cincinnati
Children’s Hosp. and The Ohio State Univ.
4:15 432.6
Perinatal Exposure to Aflatoxins Is Associated
with a Lower Rate of Weight Gain among HIV-Infected
Pregnant Women and Reduced Linear Growth of HIV-Exposed
Infants. B.K. Natamba, J-S. Wang, S.L. Young, S. Ghosh, J.K.
Griffiths. Harvard Univ., Gulu Univ., Uganda, Univ. of Georgia,
Cornell Univ. and Tufts Univ.
4:30 432.7
Pre-pregnancy Energy Balance, Gestational
Weight Gain, and Small-for-Gestational Age in Rural
Gambia: The Early Nutrition and Immune Development Trial
(ISRCTN49285450). W. Johnson, S.A.A. Elmrayed, A.M.
Prentice, S.E. Moore. MRC Human Nutr. Res., Cambridge
and MRC Unit, The Gambia, London.
4:45 432.8
Non-responsive Feeding Behaviors Are
Negatively Associated with Growth and Dietary Diversity at 24
Months in Rural Bangladesh. Z.T. Chowdhury, K.M. Hurley,
M. Jahan, S. Shaikh, S. Mehra, H. Ali, A.A. Shamim, P.
JiVitA Proj., Bangladesh.
Chaired: S. Colby
Cochaired: M. Cardel
3:00 433.1
Increasing Physical Activity in American Indian
Adults: Preliminary Results from a Multi-institutional Obesity
Prevention Program. L. Redmond, T. Eckmann, M. Pardilla, J.
Swartz, H. Platero, J. Gittelsohn. Johns Hopkins Bloomberg
Sch. of Publ. Hlth.
3:15 433.2
Does the Left Hand Know What the Right
Hand Is Doing? Part Ii: Alignment between the AFRI Childhood
Obesity Prevention Challenge Area Program and the 2010
Dietary Guidelines. M.M. Koenings, C. Perez, K. Krishnan,
D.N. Chester. IFSN, NIFA, Washington, DC and Texas A&M
Univ., Bryan.
3:30 433.3
Energy Balance-Related School Environment/
Policy Factors and Childhood Obesity in China: A National
Study of 19,487 Students from 112 Middle Schools. M. Li, H.
Xue, J. Min, M. Wen, W. Wang, Y. Wang. Univ at Buffalo, SUNY,
Univ of Utah and Renmin Univ of China, Beijing.
3:45 433.4
Camp NERF: Efficacy of a Theory-Based
Nutrition Education Recreation and Fitness Program Aimed at
Preventing Unhealthy Weight Gain in Disadvantaged Children
during Summer Months. L.C. Hopkins, C. Gunther. The Ohio
State Univ.
4:00 433.5
Parental
Expectations
and
Sedentary
Behaviors among Chinese Children: A National Study of
15,736 Students from 112 Middle Schools. M. Li, H. Xue, J.
Min, Y. Wang. Univ at Buffalo, SUNY.
4:15 433.6
Consistent Weight Gain Tracking Is Associated
with a Reduction in Gestational Weight Gain in High Income
Women. C.M. Olson, M.L. Graham, M.S. Strawderman.
Cornell Univ.
4:30 433.7
Sustaining the Youth-Leader Program in
Baltimore City Recreation Centers: Formative Research
Findings. A. Trude, E. Anderson Steeves, C. Shipley, M.J.
Mejía Ruiz, S. Priscila, L. Lachenmayr, J. Gittelsohn. Johns
Hopkins Univ., Univ. of Tennessee, Knoxville, Fed. Univ. of São
Paulo, Brazil and Univ. of Maryland Ext., Columbia, MD.
4:45 433.8
Overweight and Obesity, Weight Perception,
and Weight Management Practices among Supplemental
Nutrition Assistance Program Education Participants in
Georgia. C. Bailey, J.S. Lee, B. Olubajo. Univ. of Georgia
129
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NUTRITION/ PATHOLOGY
TUESDAY
434. RESEARCH AND PARTNERSHIP
OPPORTUNITIES WITHIN THE NATIONAL
NUTRITION RESEARCH ROADMAP
(ANDP) FORUM
Special Session
(Supported by Association of Nutrition Departments and
Programs )
Tue. 3:00 pm—San Diego Convention Center, Room 28DE
Opportunities Relevant to the National Nutrition
Research Roadmap. D.M. Klurfeld. USDA,
Beltsville, MD.
3:45 Examples of Interagency Collaborations and Public
Partnerships to Advance Nutritional Sciences Research.
• NIH—Vitamin D Standardization Program: Progress
and New Opportunities. C.T. Sempos. ODS, NIH.
• USDA—Branded Food Products Database for Public
Health: Novel Research Resource. P.E. Starke-Reed.
USDA, Beltsville, MD.
4:05Discussion.
Chaired: N. Hord
435. DANONE INTERNATIONAL PRIZE IN NUTRITION
AWARD CEREMONY AND LAUREATE LECTURE
Cochaired: R. Ballard
3:00
Overview of the National Nutrition Research Roadmap:
Purpose, Research Questions and Identification of
Research Gaps. R. Ballard. ODP, NIH
3:15 NIH Research Activities Addressing Research
Opportunities Relevant to the National Nutrition
Research Roadmap. P.M. Coates. ODS, NIH
3:30 USDA Research Activities Addressing Research
Award Lecture
(Sponsored by: Danone Institute International.)
Ballroom 20D
Pathology
436. AUTOPHAGY: BASIC MECHANISMS
AND PATHOPHYSIOLOGY
437. SOCIETY OF TOXICOLOGIC PATHOLOGY
SYMPOSIUM: AQUATIC TOXICOLOGY AND
LESSONS FOR PREVENTION OF DISEASE
Symposium
Symposium
Chaired: W-X. Ding
Cochaired: M.J. Czaja
(Sponsored by: the ASIP Environmental and
Toxicologic Scientific Interest Group and the Society of
Toxicologic Pathology)
Immunopathology
Chaired: E. Galbreath
Cell Death
Cochaired: D.A. Gorelick
8:30
Cellular Nutrient Signaling and Cell Growth Regulation.
K-L. Guan. UCSD.
9:00 Mechanisms of Selective Autophagy of Subcellular
Organelles. S. Subramani. UCSD.
9:30
Autophagy in Innate Immunity and NASH. M. Czaja.
Albert Einstein Col. of Med.
10:00 Autophagy in Pancreatitis. A. Gukovskaya. UCLA.
10:30 Autophagy and Drug-Induced Liver Injury. W-X. Ding.
Univ. of Kansas Med. Ctr.
11:00 Autophagy in Cardiovascular Diseases. R. Gottlieb.
Cedars-Sinai Heart Inst.
Environmental and Toxicologic Pathology
8:30
Overview of Zebrafish Pathology & Model Use Screening
Environmental Toxicology and Pharmaceutical Safety.
J. Engelhardt. ISIS Pharmaceuticals.
9:30
Endocrine Disrupting Activity Associated with Hydraulic
Fracturing for Natural Gas. S. Nagel. Univ. of Missouri.
10:30Environmental
Estrogens
and
Cardiovascular
Development: New Roles for Old Hormones.
D. Gorelick. The Univ. of Alabama at Birmingham.
Visit the Exhibits
April 3–April 5
Exhibit Hours
130
TUESDAYPATHOLOGY
438. STRUCTURE AND REGULATION OF
INTERCELLULAR JUNCTIONS: QUEST FOR
NEW MOLECULES AND MECHANISMS
Symposium
Chaired: A. Ivanov
Cochaired: A. Nusrat
8:30
Regulation of Adherens Junction Protein Assemblies
by Mechanical Force. W. Weis. Stanford Univ. Sch.
of Med.
9:15
Tension and the Regulation of Endothelial Junctions.
A. Malik. Univ. of Illinois at Chicago.
10:00 New Insights into Functional Coupling of Actin to the
Tight Junction Barrier. J. Anderson. NIH.
10:45 Desmogleins as Signaling Hubs to Integrate Cell
Adhesion and Cell Behaviour. J. Waschke.
LMU Munich.
439. TUMOR PROGRESSION METABOLISM
AND METASTASIS
Minisymposium
Chaired: W-K. Lee
9:50 439.6
Overexpression of Ghrelin Is Associated
with Poor Prognosis of Renal Cell Carcinoma and Promotes
Metastasis through GHSR-Mediated Activation of AKT-Snail
Pathway. T-C. Lin, S-L. Hsu, M. Hsiao. Acad. Sinica, Taipei
and Taichung Veterans Gen. Hosp., Taiwan.
10:05 439.7
Long Non-coding RNA HOTAIR Activation
by TGF-Beta1 Induces Epithelial Mesenchymal Transition in
T24 Bladder Carcinoma Cells. R. Barbosa de Oliveira Brito,
C.S. Malta, Y.S.T. Matos, D.M. Souza, L.H.G. Matheus, M.A.
Dalboni, H. Dellê. Nove de Julho Univ., São Paulo.
10:20 439.8
The Role of p120-Catenin and PIK3Ca in
Migration in Head and Neck Squamous Cell Carcinoma.
M. Kidacki, H.L. Lehman, P.A. Welsh, J.I. Warrick, D.B.
Stairs. Penn State, Hershey.
10:35 439.9
Epigenetic Regulation of Epithelial Cellular
Fate by CTBP. J.S. Byun, K. Gardner. NCI, NIH.
10:50 439.10 FoxP3+ T-Cells and PD-L1 Highlight ImmuneSuppressive Profiles in Vulvar Squamous Cell Carcinoma.
E.R. Holthoff, T. Kelly, C.M. Quick, S.R. Post. Univ. of
Arkansas for Med. Sci.
11:05 439.11 Regulative Loop between β-Catenin and
Protein Tyrosine Phosphatase Receptor Type γ in Chronic
Myeloid Leukemia. L. Tomasello, M. Vezzalini, Z. Fiorini, N.
Al-Dewik, M. Yassin, C. Sorio. Univ. of Verona and Hamad
Med. Corp., Qatar.
440. SCIENTIFIC SLEUTHING OF HUMAN DISEASE
FOR UNDERGRADUATE STUDENTS AND HIGH
SCHOOL TEACHERS AND STUDENTS
Special Session
Cochaired: J. McHowat
(Supported by an unrestricted educational grant from the
Intersociety Council for Pathology Information)
Cancer Biology
(Sponsored by: the ASIP Education Committee)
Tumor Microenvironment and Metastasis
Tue. 9:30 am—San Diego Marriott Marquis & Marina
Hotel, Marina Ballroom G
Neoplasia
8:30
Introductory Remarks.
8:35 439.1
Disease-Associated Polymorphisms in Mnsod
and GPx-1 Affect Metabolism, Mitochondrial Membrane
Potential and Expression of Signaling Proteins. D.N. Ekoue,
S. Bera, E. Ansong, P. Hart, V. Macias, A. Kajdacsy-Balla, M.
Bonini, A.M. Diamond. Univ. of Illinois at Chicago.
8:50 439.2
Upregulation of the Multidrug Resistance
P-Glycoprotein ABCB1 by Transcription Factor Pituitary
Homeobox 2 in Human Colon and Kidney Cancers. W-K. Lee,
F. Thévenod. Univ. of Witten/Herdecke, Germany.
9:05 439.3
SIRT5 in Cancer Metabolic Reprogramming.
D.B. Lombard, J. Park, S. Kumar. Univ. of Michigan.
9:20 439.4
The Role of Twist1 Phosphorylation in Tumor
Angiogenesis in Lung Cancer. T. Mammoto, A. Jiang, E.
Jiang, A. Mammoto. Boston Children’s Hosp.
9:35 439.5
A Novel Signaling Pathway That Governs
Tumor Metastasis: Ceramide Regulates Direct Crosstalk
between TGF-Β and Sonic Hedgehog Signaling. S. Gencer,
B. Ogretmen. Med. Univ. of South Carolina and Uskudar Univ.
and Abdullah Gul Univ., Turkey.
Cochaired: M.B. Furie
Education
Pulmonary Pathobiology
Regenerative Medicine and Stem Cells
9:30
Check In.
10:00 Welcome and Introductions. K. Nejak-Bowen. Univ.
of Pittsburgh.
10:20 Menacing Microbes: Emerging Infectious Diseases.
M. Furie. Stony Brook Univ.
11:20 Smoking-Related Lung Disease in 3D: Not Your
Standard Lecture. P.G. Anderson, C. Caruso, J.R.
Stone, D. Zander. Penn State Milton S. Hershey
Med. Ctr. Univ. of Alabama at Birmingham and
Massachusetts Gen. Hosp.
12:15 Stem Cells: A Case of Dr. Jekyll and Mr. Hyde. S. Monga.
Univ. of Pittsburgh.
1:15
Tour the Exhibits at the San Diego Convention Center.
131
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PATHOLOGYTUESDAY
441. LUNCH AND LEARN: SCIENCE, STATISTICS,
AND GETTING IT RIGHT: INTERACTIVE
DISCUSSION OF COMMON PROBLEMS
(Sponsored by: the ASIP Education Committee)
Chaired: T. Li
Tue. 11:45 am—San Diego Marriott Marquis & Marina
Hotel, Miramar
Cochaired: C.C. Yates
Chaired: D.A. Milner, Jr.
442. EMERGING STRATEGIES TO
RESOLVE INFLAMMATION
Symposium
Chaired: C.N. Serhan
Cochaired: K. Gronert
Immunopathology
2:45
3:30
4:15
Novel Mediators and Mechanisms in Resolution of
Inflammation. C. Serhan. Brigham & Women’s Hosp.
Sex Specific Regulation of Tissue PMN and Lipid
Mediator Circuits Controls T Cell Responses in the
Eye. K. Gronert. Univ. of California - Berkeley.
Mesenchymal Stem Cells May Promote the Resolution
of Acute Lung Injury. M. Matthay. UCSF.
Resolving Vascular Injury: Translational Implications for
Cardiovascular Intervention. M. Conte. UCSF.
443. LIVER PATHOBIOLOGY SYMPOSIUM: LIVER
PROGENITORS IN HEALTH AND DISEASE
Symposium
(Supported by: an unrestricted educational grant from
Samsara Science, Inc.)
(Sponsored by: the ASIP Liver Pathobiology Scientific
Interest Group)
Cochaired: H. Willenbring
Liver Pathobiology
2:00
3:10
3:45
4:20
132
Minisymposium
Special Session
An interactive lunch session will include an opportunity
for participants to review 5 case vignettes featuring a common
problem in scientific research statistics followed by a presentation
and discussion with statistical faculty. The Do’s, Dont’s, and
Pitfalls of these methods will be highlighted and discussed.
2:00
444. AUTOPHAGY, CELL DEATH, AND
TISSUE INJURY
Oval Cells. B. Petersen. Univ. of Florida.
Beta-Catenin in Transdifferentiation. K. Nejak-Bowen.
Lineage Tracing. H. Willenbring. UCSF.
Progenitors in Fibrosis and Cancer. T. Kisseleva. UCSD.
Immunopathology
Cell Death
2:00 444.1
Development of the Metabolic Syndrome
Leads to Increased Ischemic Injury and Is Associated with
Dysregulated Cardiac Fasting Response and Attenuation of
Autophagy in Mice. A. Andres, J. Kooren, K. Tucker, S. Parker,
E. Crowgey, N. Ravindran, B. Ito, R. Gottlieb, J. Van Eyk, R.
Mentzer. Cedars-Sinai Med. Ctr. and San Diego State Univ.
2:15 444.2
Regulation of Cardiac Autophagic Flux In Vivo
by the Ubiquitin Ligase Muscle Ring Finger-1. T.L. Parry, M.S.
Willis. Univ. of North Carolina at Chapel Hill.
2:30 444.3
Targeting the Enterohepatic Bile Acid Signaling
to Modulate Hepatic Autophagic Activity in Non-alcoholic
Steatohepatitis. Y. Wang, Y. Ding, J. Li, H. Chavan, D. Matye,
H. Ni, P. Krishnamurthy, W-x. Ding, T. Li. Univ. of Kansas
Med. Ctr.
2:45 444.4
Nrf2 but Not Autophagy Activation Is
Associated with Resistance to EGFR Inhibitor-Induced Lung
Tumor Cell Apoptosis. Y. Li, Y. Zhou, H-M. Ni, H. Zhong, W-X.
Ding. Univ. of Kansas Med. Ctr. and Chest Hosp., Shanghai
Jiaotong Univ., China.
3:00 444.5
High MUC2 Biosynthesis Induce ROS
Production Which Increases Goblet Cell Susceptibility to ER
Stress and Apoptosis. A. Tawiah, F. Moreau, K. Chadee. Univ.
of Calgary, Canada.
3:15 444.6
Targeting
Macrophage
Necroptosis
for Therapeutic and Diagnostic Interventions to Treat
Atherosclerosis. D. Karunakaran, M. Geoffrion, L. Wei,
W. Gan, L. Perisic, L. Maegdefessel, U. Hedin, S. Sad, R.
Virmani, T. Ruddy, K. Rayner. Ottawa Heart Inst., Karolinska
Inst., Solna, Univ. of Ottawa and CVPath, Gaithersburg, MD.
3:30 444.7
Ischemia/reperfusion-Induced
Myocardial
Injury in Mice with Diabetes Mellitus: Role of Silent Information
Regulator 1. A. Tao, T. Mele, R. Kao, C. Martin, T. Rui. Affil.
People’s Hosp. of Jiangsu Univ., Lawson Hlth. Res. Inst.,
London, ON and Schulich Sch. of Med. and Dent., Western
Univ., Canada.
3:45 444.8
Hydroxylase Inhibition Reduces Transforming
Growth Factor-β1 Induced Fibrosis Associated with Colitis.
M. Manresa, M. Tambuwala, P. Radhakrishnan, J. Harnoss,
M. Cavadas, C. Keogh, A. Cheong, E. Cummins, K. Barrett,
M. Schneider, C. Taylor. Univiversity Col. Dublin, Univ. of
Heidelberg, Systs. Biol. Ireland, Dublin and UCSD.
4:00 444.9
ATF3 as an Important Factor of the Acute
Phase Lung Inflammatory Response in an Animal Model.
C.R. Caruso, N. Cabello, U. Sinha, N. Ekpa, S. DiAngelo,
Z. Chroneos, P. Silveyra. Penn State Col. of Med.
4:15 444.10 Prognostic Significance of Tissue Oxygenation
Changes and Early Signaling Responses in Fasciocutaneous
Advancement Flap Healing. E. Aksamitiene, L. Bryant, M.
Stanczak, J.R. Eisenbrey, J.B. Hoek, E.A. Pribitkin. Thomas
Jefferson Univ.
TUESDAYPATHOLOGY
4:30 444.11 Insulated Pathway Reporter Transposon Allows
for HTS Approach to Transcriptional Activation Dynamics in
Mammalian Cells. V.V. Mossine, J.K. Waters, D.L. Chance,
T.P. Mawhinney. Univ. of Missouri-Columbia.
4:45 444.12 Characterization
of
Mitochondrial
and
Metabolic Changes following Retinal Detachment. D. DiazAguilar, Z. Li, A. Khadka, S. Jacobo, K. Connor, M. SaintGeniez. Massachusetts Eye and Ear Infirm., Harvard Med.
Sch. and Angiogenesis Lab., Boston.
445. MECHANISMS IN UROGENITAL DISORDERS
AND INTERVENTIONS
4:05 445.9
Genistein Alleviates Testicular Ischemia and
Reperfusion Injury-Induced Spermatogenic Damage and
Oxidative Stress by Suppressing Abnormal Testicular Matrix
Metalloproteinase System. M. Al-Maghrebi. Kuwait Univ. Fac.
of Med.
4:20
Discussion.
446. CLUB HEPATOMANIA (LIVER PATHOBIOLOGY)
SCIENTIFIC INTEREST GROUP
SPECIAL SESSION
Special Session
(Sponsored by: ASIP Liver Pathobiology Scientific
Interest Group)
Minisymposium
Chaired: K. Gibson-Corley
Liver Pathobiology
Cochaired: P. Gaffney
2:00
Introduction.
2:05 445.1
Absence of Mast Cells in the Kidneys of Rats
Subjected to Fat Embolism Despite Their Presence in the
Lungs and Heart. C. Patel, A.N. Fletcher, A.M. Poisner, A.
Siddiqi, D. Arif, S. Hamidpour, R. Ponnapureddy, A. Molteni.
Univ. of Missouri-Kansas City and Univ. of Kansas Med. Ctr.
2:20 445.2
Increased
Indoleamine
2,3-Dioxygenase
Expression in the Renal Fibrogenesis Induced by Unilateral
Ureteral Obstruction. L.H.G. Matheus, G.M.S. Simão, T.A.
Amaral, R.B. Brito, C.S. Malta, Y.S.T. Matos, D.M. Souza, H.
Dellê. Nove de Julho Univ., São Paulo.
2:35 445.3
Molecular Subtyping and In Vivo Phenotyping
Studies Identify Human Cell Lines Suitable for Bladder Cancer
Research. J. Warrick, L. Shuman, Z. Zheng, H. Yamashita,
V.O. Amponsa, D. DeGraff. Penn State Col. of Med.
2:50 445.4
AA Amyloidosis in Island Foxes (Urocyon
littoralis): Pathology, Risk Factors, and the Genetic Basis for
Disease. P. Gaffney, C. Witte, D. Clifford, M. Ghassemian,
T. Gaasterland, C. Sigurdson. UCSD, Zool. Soc. of San
Diego, Escondido and California Dept. of Fish and Wildlife,
Rancho Cordova.
3:05 445.5
Pathophysiological
Interactions
between
Chronic Kidney Disease and Cardiac Remodelling. S. Liu, A.R.
Kompa, B.H. Wang, H. Krum. South China Univ. of Technol.,
Guangzhou Monash Univ., Melbourne.
3:20 445.6
Mechanisms Underlying the Induction of a
Profibrotic Epithelial Phenotype during Renal Fibrosis. J. Folke
Bialik, M. Rozycki, P. Speight, Z.M. Miranda, S.G. Szeto,
D.A. Yuen, Q. Dan, K. Szászi, S.F. Pedersen, A. Kapus. St.
Michael’s Hosp., Toronto, Univ. of Copenhagen and Univ.
of Toronto.
3:35 445.7
Alternation of Nephron Morphology Associated
with Sustained Delivery of Danazol Using Adult Male Rodents
as a Model. H.A. Benghuzzi, M.A. Tucci. Univ. of Mississppi
Med. Ctr.
3:50 445.8
Clomiphene Citrate and Male Infertility:
Investigation of Treatment on Spermatogenesis and Testicular
Histomorphology in a Rat Model. K. Gibson-Corley, P. Kogan,
M. Wald. Univ. of Iowa.
447. ASIP SCIENTIFIC INTEREST GROUP POSTER
DISCUSSION AND NETWORKING SESSION
Poster Discussion
(Sponsored by: ASIP Scientific Interest Groups)
Ballroom 20BC
P1
P2
P3
P4
P5
P6
P7
Global Analysis of lncRNAs in Gliomas and
Glioblastomas. B. Reon, A. Sinegra, A. Dutta. Univ.
of Virginia. (1182.1)
BAC-Based Molecular Cytogenetics: From Blood to
BAC in Just a Week. H-U.G. Weier, J.F. Weier, H.
Zeng, C-M. Lu, M. Wang. Lawrence Berkeley Natl.
Lab., UCSF and Caltech. (1182.4)
Genome-Wide
Association
Analysis
Identified
Candidate Variants Associated with Responsiveness
to a Blood Pressure Reduction Intervention in Rural
North Carolina. K.C. Lenhart, K. Robasky, W. Jones,
J. Halladay, A. Ammerman, C. Patterson, J.C.
Schisler. Univ. of North Carolina at Chapel Hill and
Quintiles, Durham, NC. (1177.15)
Sepsis-Associated Proteinase 3 Induces Endothelial
Permeability. E.K. Patterson, G. Cepinskas, K.
Inoue, D.D. Fraser. Lawson Hlth. Res. Inst., London,
ON and Western Univ., Canada. (165.5)
Increased Expression of Cytokines in a New Traumatic
Model of Abdominal Aortic Aneurysms Associated
with Hypercholesterolemic Diet in Wistar Rats. K.M.
Mata, C.R. Fernandes, C. Tefe-Silva, E.M. Floriano,
S.G. Ramos. Ribeirão Preto Med. Sch., Univ. of São
Paulo. (1177.1)
Digital Determination of Chemotherapeutic DrugInduced Damage Sites in Single DNA Molecules Using
Nanofluidic Channels. D.G. Kaufman, P.D. Chastain,
S.A. Soper. Univ. of North Carolina at Chapel Hill and
William Carey Univ. Col. of Osteo. Med., MS. (51.8)
Potential Pathological Implication of Osteocalcin and
Vitamin D in Acute Aortic Dissection. M.M. Corsi
Romanelli, E. Vianello, A. Barassi, S. Trimarchi,
E. Dozio. Univ. of Milan and IRCCS Policlin. San
Donato, Italy. (694.1)
133
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PATHOLOGYTUESDAY
P8
VTL C3A Cells Secrete Factors Involved in Coagulation
Homeostasis. S.L. Riley, D.F. Mendez, P.W. Bedard,
L.K. Landeen. Vital Therapies Inc., San Diego.
(924.10)
P9
Sequence Variation in Hepatitis B Virus Variants
of Chronically Infected Saudi Patients and Their
Interaction with Host Genetic Factors. F.N. Almajhdi,
A. Al-Qudari, H.M. Amer, A.A. Abdo. Col. of Sci. and
Col. of Med., King Saud Univ. (925.5)
P10
Rift Valley Fever Virus Protein Detected by Multiple
Immunohistochemical Methods. M. Gamez, B.
Faburay, B.S. Drolet, W.C. Wilson, J.A. Richt, A.S.
Davis, E. Stietzle. Col. of Vet. Med., Kansas State
Univ. (925.16)
P11Targeting CSE1L in Colorectal Cancer. J. Pimiento,
K.G. Neill, E. Henderson-Jackson, S. Eschrich,
D-T. Chen, K. Husain, D. Shibata, D. Coppola, M.
Malafa. Moffitt Cancer Ctr., Tampa. (515.5)
P12
EXPEL: A Novel Non-destructive Method for Mining
Soluble Tumor Biomarkers. A. Turtoi, B. Costanza,
O. Peulen, A. Bellahcène, E. De Pauw, O. Detry, P.
Delvenne, V. Castronovo. Univ. of Liege and Univ.
Hosp. Liege, Belgium. (515.2)
P13
Single-Cell Biomarker Detection Identifies Heterogeneity
within Cancer Populations. D. Weldon, Y. Williams, A.
Patel. EMD Millipore, CA. (515.4)
P14 A New Composite Biomarker for Cervical Cancer
Diagnosis. O. Markovic, N. Markovic. Global Acad.
for Women’s Hlth. and BioSciCon Inc., Rockville, MD.
(696.5)
P15 CD44, CD133 and Lgr5 as Biomarkers for Early
Detection of H. pylori-Associated Gastric Cancer. R.
Walker, J. Mejia, H. Enderling, J.M. Pimiento, M.
Malafa, D. Coppola. Moffitt Cancer Ctr., Tampa and
Pathol. Inst. Mejia Jimenez, Colombia. (696.4)
P16
Overexpression of Ghrelin Is Associated with Poor
Prognosis of Renal Cell Carcinoma and Promotes
Metastasis through GHSR-Mediated Activation of
AKT-Snail Pathway. T-C. Lin, S-L. Hsu, M. Hsiao.
Acad. Sinica, Taipei and Taichung Veterans Gen.
Hosp., Taiwan. (439.6)
P17
Influence of PI3K and MAPK Pathway Mutations on
Response to Mono and Dual Treatment with Targeted
Kinase Inhibitors. R.S. McNeill, D.A. Canoutas, R.E.
Bash, R.S. Schmid, B.H. Constance, G.L. Johnson,
C.R. Miller. Univ. of North Carolina at Chapel Hill.
(515.1)
P18
Exploring the Proteomic and Genomic Relationships
between CtBP Expression and Metabolic Imbalance
in Breast Cancer. L. Crawford, R. Hernandez-Mora,
S. Park, J.S. Byun, K. Gardner. NIMHD, NIH and
NCI, NIH. (698.13)
P19
Characterizing Breast Cancer Stem Cell Populations In
Vitro Using the Sore6 Gene Reporter System. D. Li,
D.I. Yi, S. Park, G. Liang, M. Kabbout, J. Byun, K.
Gardner. NIMHD and NCI, NIH. (698.10)
P20
Intronic Regulation of Human GLI1 DNA by cis DNA
Elements and Epigenetic Marks. P. Iannaccone, R.
Taylor, J. Long, R. Childs, J. Yoon, K. Sylvestersen,
M.L. Nielsen, D.O. Walterhouse, D. Robbins.
Northwestern Univ., Univ. of Miami and Univ. of
Copenhagen. (1180.1)
134
P21
P22
P23
P24
P25
P26
P27
P28
P29
P30
P31
P32
P33
P34
Insulated Pathway Reporter Transposon Allows for HTS
Approach to Transcriptional Activation Dynamics in
Mammalian Cells. V.V. Mossine, J.K. Waters, D.L.
Chance, T.P. Mawhinney. Univ. of Missouri-Columbia.
(444.11)
Epigenetic Silencing of MicroRNA-34a in Human
Cholangiocarcinoma Cells via DNA Methylation and
EZH2: Impact on Regulation of Notch Pathway. H.
Kwon, K. Song, C. Han, J. Zhang, N. Ungerleider, L.
Yao, T. Wu. Tulane Univ. (56.3)
The Histone Deacetylase Sirt2 Regulates Slug in BasalLike Breast Cancer. W. Zhou, C. Kuperwasser. Tufts
Univ. Sch. of Med. and Tufts Univ. (698.5)
Regulome-Seq: Searching for Single Nucleotide
Variants Associated with Disease beyond ProteinCoding Regions. M. Pinsach-Abuin, J. Mates, B. del
Olmo, C. Allegue, R. Brugada, I. Garcia-Bassets, S.
Pagans. Univ. of Girona, Spain, UCSD. (1180.4)
Knockdown of Mechanosensitive miRNA Cluster—miR106b~25 Decreases Endothelial Proliferation and
Prevents Atherosclerosis in ApoE-/- Mice. S. Kumar,
H. Jo. Emory Univ. (165.1)
Whole Transcriptome Analysis of Osteosarcoma. S.
Koks, E. Reimann, K. Maasalu, G. Koks, D.H. Xuan,
E. Prans, A. Martson. Univ. of Tartu, Estonia. (515.6)
Long Non-coding RNA HOTAIR Activation by TGFBeta1 Induces Epithelial Mesenchymal Transition
in T24 Bladder Carcinoma Cells. R. Barbosa de
Oliveira Brito, C.S. Malta, Y.S.T. Matos, D.M. Souza,
L.H.G. Matheus, M.A. Dalboni, H. Dellê. Nove de
Julho Univ., São Paulo. (439.7)
The Role of CtBP in Tumor Progression: Insights from
the Pinducer Inducible Gene Expression System. D.I.
Yi, D. Li, S. Park, L. Crawford, G. Liang, M. Kabbout,
R. Hernandez-Mora, T. Yan, J. Byun, K. Gardner.
NCI, NIH. (698.11)
Cellular Stress Response 1 Regulates RNA Splicing
of Epidermal Growth Factor Receptor and PlateletDerived Growth Factor Receptor through Inactivation
of Splicing Factor 3A3. J. Luo, Z-H. Zuo, Y.P. Yu. Univ.
of Pittsburgh. (920.4)
Aberrant Modulation of the BRCA1 and G1/S Cell Cycle
Pathways in Alcoholic Hepatitis Patients with Mallory
Denk Bodies Present Revealed by RNA Sequencing.
H. Liu. LA BioMed/Harbor UCLA Med. Ctr. (924.12)
Deterministic Transfection and Genetic Manipulation of
Organotypic Brain Slice Cultures for Ex Vivo Imaging.
P.E. Gygli, S. Byers, N. Higuita-Castro, C. Czeisler,
D. Gallego-Perez, J.J. Otero. The Ohio State Univ.
and Kenyon Col., OH. (51.9)
MicroRNA Profiling in Rat Model of Neurofibrillary
Degeneration. M. Cente, N. Kosikova, P. Filipcik,
M. Novak. Inst. of Neuroimmunol. SAS and Axon
Neurosci. SE, Bratislava, Slovakia. (1180.5)
Role of Gfi1 Transcription Factor in Myeloma Cells
Growth and Survival. D.N. Petrusca, C. Park, F.
Wang, J. Anderson, D.G. Roodman. Indiana Univ.
and Richard L. Roudebush VA Med. Ctr., Indianapolis.
(1180.6)
Twist1 Phosphorylation Contributes to Pulmonary
Fibrosis through Angiopoietin-Tie2 Signaling. A.
Mammoto, A. Jiang, E. Jiang, T. Mammoto. Boston
TUESDAYPATHOLOGY
P35
P36
P37
P38
P39
P40
P41
P42
P43
P44
P45
P46
P47
P48
Dysregulation of miRNA Regulatory Networks by Chronic
Ethanol Consumption Impairs Liver Regeneration. A.
Parrish, E. Juskeviciute, J.B. Hoek, R. Vadigepalli.
Thomas Jefferson Univ. (56.10)
Epigenetic Regulation of Epithelial Cellular Fate by
CTBP. J.S. Byun, K. Gardner. NCI, NIH. (439.9)
Apigenin Attenuates CCL2 Release from TNFα and IL1a Stimulated MDA-MB-231 Triple Negative Breast
Cancer Cells. D.F. Bauer, E.A. Mazzio, K.F. Soliman.
Col. of Pharm. and Pharmaceut. Sci., Florida A&M
Univ. (698.14)
PEDF Reduction Induced by Cigarette Smoke: A
Potential Role for Breast Tumor Development. S.E.
Kispert, J. McHowat. Saint Louis Univ. Sch. of Med.
(698.12)
Exploring Molecular and Morphological Relationships
between Obesity and CtBP in Breast Cancer.
S.S. Park, D.I. Yi, D. Li, L. Crawford, G. Liang, M.
Kabbout, R. Hernandez, T. Yan, S. Ambs, J.S. Byun,
K. Gardner. NCI and NIMHD, NIH. (515.9)
PAF/PAF-R Expression and Effects of Cigarette Smoke
Exposure in Human Breast Cancer. S.E. Kispert,
T. Schwartz, J. McHowat. Saint Louis Univ. Sch. of
Med. (698.4)
Expression and Function of Androgen Receptor in
Human Breast Cancer-Associated Fibroblasts: May
Androgens Shape Breast Tumor Microenvironment?
M. Lanzino, A. Campana, C. Giordano, I. Barone, D.
Bonofiglio, S. Catalano, S. Andò. Univ. of Calabria,
Italy. (698.9)
Breast Cancer Emergence from Dormancy Can Be
Activated by Hepatic Stellate Cells. A.S. Khazali, A.
Clark, S. Wheeler, A. Wells. Univ. of Pittsburgh and
VA Pittsburgh Healthcare Syst. (698.8)
Control of Breast Cancer through the Resolution of
Inflammation. D.R. Vatnick, K. Lehner, M. Gilligan,
D. Panigrahy, Y. Gus-Brautbar, S. Ramon, S. Huang,
C. Serhan. Beth Israel Deaconess Med. Ctr., Harvard
Med. Sch., Brigham and Women’s Hosp. and Inst. for
Systs. Biol., Seattle. (698.3)
TIMP-2: A Novel Biologic Therapy for Triple Negative
Breast Cancer. N.P. Castro, A. Chowdhury, S.M.
Jensen, F. Cuttitta, W.G. Stetler-Stevenson, D.
Solomon. NCI at Frederick and NCI at Shady Grove,
MD. (698.2)
Lactate Dehydrogenase A May Not Be Primarily
Responsible for Maintaining High Tumor Lactic Acid
Levels in Aggressive Breast Cancer. N. Mack, E.
Mazzio, K. Soliman. Florida A&M Univ. (698.1)
Characterizing Bone Tropism of Human ER+ Breast
Cancer Cell Lines in a Murine Bone Metastasis
Model. J.N. Cheng, J.B. Frye, S.A. Whitman, J.L.
Funk. Univ. of Arizona. (698.15)
Breast Tumor Development and Cigarette Smoking:
Accelerated Tumor Development in Calcium
Independent Phospholipase A2γ Deficient Mice.
S.E. Kispert, J. McHowat. Saint Louis Univ. Sch. of
Med. (698.6)
The Critical Role of SENP1-Mediated GATA2
DeSUMOylation in Graft Arteriosclerosis by Promoting
Endothelial Activation. C. Qiu, Y. Wang, X. Zhu, L.
Song, H. Zhang, L. Qin, G. Tellides, W. Min, L. Yu.
Zhejiang Univ. Col. of Life Sci., China and Yale Univ.
P49
Platelets Direct Leukocytes to Their Sites of
Extravasation. G. Zuchtriegel, B. Uhl, D. PuhrWesterheide, M. Pörnbacher, K. Lauber, F.
Krombach, C.A. Reichel. Ludwig Maximilian Univ. of
Munich. (165.7)
P50 JAM-C Deficiency Primes Endothelial Cells for a
Pro-inflammatory State. N. Reglero, R. Beal, C.
Cabrera, C. Pickworth, M. Golding, J. Whiteford, T.
Nightingale, B. Imhof, M.R. Barnes, S. Nourshargh.
Barts and London Sch. of Med. and Dent., Queen
Mary Univ. of London and Ctr. Med. Univ., Univ. of
Geneva. (165.10)
P51 Cell-Type Specific Mechanisms Regulate Rhythmic
Leukocyte Migration to Tissues. W. He, K. Kraus,
D. Druzd, A. de Juan, L. Ince, C-S. Chen, C.
Scheiermann. Ludwig Maximilians Univ., Munich.
(165.11)
P52
Neuropilin 2 Deficiency Prolongs Skin Inflammation and
Edema. D.R. Bielenberg, P. Mucka, N. Levonyak,
E. Geretti, B.M.M. Zwaans, X. Li, I. Adini, M.
Klagsbrun, R.M. Adam. Harvard Med. Sch., Boston
P53
Endotoxin-Stimulated Hepatic Stellate Cells Increase
Suppressive Potential of Regulatory T Cells via IDOMediated AhR Activation: Therapeutic Implications. S.
Kumar, A. Dangi, C.R. Gandhi. Univ. of Cincinnati
and Cincinnati Children’s Hosp. Med. Ctr. (57.7)
P54 Differential Regulation of Macrophage Glucose
Metabolism by M-CSF and GM-CSF: Implications for
18
F-FDG PET Imaging of Inflammation. S. Tavakoli,
J.D. Short, K. Downs, N. Huynh Nga, R. Asmis.
Univ. of Texas Hlth. Sci. Ctr. at San Antonio. (57.8)
P55
Vesicle Fusion Protein, YKT6, Is a Novel Regulator
of Epithelial Cell-Matrix Adhesion and Migration. A.
Ivanov, N. Naydenov, S. Joshi, A. Feygin. Virginia
Commonwealth Univ. (305.5)
P56
Intestinal Epithelial Cell Expression of CD47 Facilitates
Proliferation, Neutrophil Transmigration, and Wound
Healing In Vivo. M. Reed, A-C. Luissint, A. Nusrat,
C.A. Parkos. Univ. of Michigan. (305.6)
P57
Cortactin Is Required to Maintain Intestinal Epithelial
Barrier Homeostasis. A.F. Citalán-Madrid, A. GarcíaPonce, H. Vargas-Robles, A. Betanzos, P. Nava, K.
Rottner, R. Menningen, M. Schnoor. CINVESTAVIPN, Mexico City, Tech Univ. Braunschweig and Univ.
Hosp. Münster, Germany. (305.8)
P58
The Specialized Pro-resolving Lipid Mediator Resolvin
E1 Promotes Intestinal Mucosal Wound Repair. M.
Quiros, H. Nishio, G. Leoni, R. Agarwal, G. Bernal,
C. Gerner-Smith, C. Gerner-Smith, R. Colas, K.
Graham, C. Serhan, A. Garcia, C. Parkos, A. Nusrat.
Univ. of Michigan, Inst. for Cardiovasc. Prevent.,
Munich, Georgia Tech, Emory Univ. and Harvard
Univ. (305.7)
P59
Keratin Filaments Regulate Binding Properties of the
Desmosomal Adhesion Molecule Desmoglein 3. F.
Vielmuth, F. Loschke, T.M. Magin, J. Waschke, V.
Spindler. Ludwig Maximilians Univ. Munich and Univ.
of Leipzig. (305.4)
135
T
U
E
PATHOLOGYTUESDAY
P60
Role of Hypoxia-Inducible Factor on Colonic Goblet Cell
Differentiation and Function during Mucosal Healing.
A.K. Whitney, K.D. Schwisow, A.J. Bayless, L.
Golden-Mason, G. Mehta, K.A. Kuhn, S.P. Colgan,
E.L. Campbell. Univ. of Colorado Anschutz Med.
Campus. (305.10)
P61 Sympathetic Signaling Regulates Cardiomyocyte
Cohesion via the Plaque Protein Plakoglobin. C.
Schinner, A. Schlipp, V. Rötzer, F. Vielmuth, A.
Messoudi, A. Horn, V. Spindler, J. Waschke. Ludwig
Maximilians Univ. Munich. (305.9)
P62
Central Role for Intestinal Epithelial IL-10R1 Signaling
in Barrier Restitution. J.M. Lanis, E.E. Alexeev,
D.J. Kao, D.A. Kitzenberg, K.D. Schwisow, D.J.
Kominsky, S.P. Colgan. Univ. of Colorado Anschutz
Med. Campus and Montana State Univ. (305.2)
P63
Cell Differentiation in the Murine Intestine Requires
NADPH Oxidase 1. T. Darby, R. Jones. Emory Univ.
(57.3)
P64
High MUC2 Biosynthesis Induce ROS Production Which
Increases Goblet Cell Susceptibility to ER Stress and
Apoptosis. A. Tawiah, F. Moreau, K. Chadee. Univ. of
Calgary, Canada. (444.5)
P65
Cleavage of the Osmotic Stress-Related Transcriptional
Regulator NFAT5 Is Critical for Cardiac Injury in
Coxsackievirus B3-Induced Myocarditis. Y. Qiu, P.J.
Hansen, M. Zhang, D. Yang. Univ. of British Columbia
and Ctr. for Heart Lung Innovation, Vancouver.
(920.10)
P66
Targeting Macrophage Necroptosis for Therapeutic and
Diagnostic Interventions to Treat Atherosclerosis.
D. Karunakaran, M. Geoffrion, L. Wei, W. Gan,
L. Perisic, L. Maegdefessel, U. Hedin, S. Sad, R.
Virmani, T. Ruddy, K. Rayner. Ottawa Heart Inst.,
Karolinska Inst., Solna, Univ. of Ottawa and CVPath,
Gaithersburg, MD. (444.6)
P67
Functional Diversity of Novel Disease Mutations in the
Unfolded Protein Response Regulator, ATF6. W-C.
Chiang, P. Chan, J.H. Lin. UCSD. (920.13)
P68 Characterization of Mitochondrial and Metabolic
Changes following Retinal Detachment. D. DiazAguilar, Z. Li, A. Khadka, S. Jacobo, K. Connor, M.
Saint-Geniez. Massachusetts Eye and Ear Infirm.,
Harvard Med. Sch. and Angiogenesis Lab., Boston.
(444.12)
P69
ATF3 as an Important Factor of the Acute Phase Lung
Inflammatory Response in an Animal Model. C.R.
Caruso, N. Cabello, U. Sinha, N. Ekpa, S. DiAngelo,
Z. Chroneos, P. Silveyra. Penn State Col. of
Med. (444.9)
P70 Transgenic Up-Regulation of Claudin-6 Decreases
Diesel Particulate Matter-Induced Pulmonary
Inflammation. J. Bodine, J. Gassman, D.C. Milner,
A. Lewis, T. Dunaway, K. Egbert, C. Christiansen,
A. Christiansen, T. Monson, D. Broberg, J. Arroyo,
P.R. Reynolds. Brigham Young Univ. (305.11)
P71
The Roles of Matrix Metalloproteinases in Anterior
Regeneration in Aeolosoma viride. T.L. Tseng. Natl.
Taiwan Univ. (923.2)
136
P72
Alveolar Lipid Accumulation in GMCSFRβ KO Mice
Involves Epithelial Steatosis as Well as Macrophage
Lipotoxicity and Is Not Associated with Altered
Surfactant Lipid Synthesis. D.J. Corkill, A.N.
Hunt, M.J. Hinrichs, M.C. Rebellato, P. Ryan, A.
Scott, M.A. Sleeman, A.D. Postle. MedImmune
Ltd, Cambridge, U.K., Univ. of Southampton and
MedImmune, Gaithersburg, MD. (921.2)
P73 Allergen-Induced Endoplasmic Reticulum Stress
Regulates Lung Inflammation and Fibrosis. S.
Jalahalli Mariswamy, E.M. Nakada, B. Mihavics,
S. Hoffman, D. Chapman, C.G. Irvin, A. Dixon, M.
Poynter, V. Anathy. Univ. of Vermont. (50.3)
P74
Mitochondrial Dysfunction in iPSC-Derived Neurons in
Subjects with Chronic Mountain Sickness. H. Zhao, G.
Perkins, D. Callacondo, O. Appenzeller, G. Haddad.
UCSD, Lima, Peru and Univ. of New Mexico. (1179.9)
P75 NLRP3 Inflammasome as a Novel Target for
Docosahexaenoic Acid and Its Metabolites to Abrogate
Glomerular Injury during Hyperhomocysteinemia. Z.
Chen, S.M. Conley, G. Li, M. Xia, T.W. Gehr, K.M.
Boini, P-L. Li. Virginia Commonwealth Univ. (701.1)
P76
Behavioral Effects of a Novel Allosteric Potentiator of the
Dopamine D1 Receptor in Human D1 Knock-In Mice
and Rhesus Monkeys. K.A. Svensson, J.P. Beck,
J. Hao, J.M. Schaus, D.L. Maren, M.M. Menezes,
J.F. Falcone, W. Anderson, K. Knopp, B.L. Adams,
J.M. Witkin, X. Li, J. Cramer, A.J. Harper, K.A.
Wafford, L. Zhang, C.R. Yang, R.F. Bruns. Eli Lilly,
Indianapolis and Erl Wood, U.K. and Chempartner,
Shanghai. (708.2)
P77
Expression of Nerve Membrane Proteins in a Naturally
Occurring Ca2+ Channelopathy. N. Colón-Carrion, A.
Colón-Rodriguez, W.D. Atchison. Univ. of Puerto
Rico at Cayey and Michigan State Univ. (1188.5)
P78
Assessment of Autofluorescent Signatures in Multiple
Tissue Types with Novel Excitation-Scanning
Hyperspectral Imaging. P.F. Favreau, J.A. Deal, D.A.
Weber, T.C. Rich, S.J. Leavesley. Univ. of South
Alabama. (51.1)
P79
MUSE: A New, Fast, Simple Microscopy Method for
Slide-Free Histology and Surface Topography. R.M.
Levenson, F. Fereidouni. Univ. of California Davis
Med. Ctr., Sacramento. (51.3)
P80 Potential of Hyperspectral Imaging for Label-Free
Tissue and Pathology Classification. J.A. Deal, P.
Favreau, D. Weber, T. Rich, S. Leavesley. Univ. of
South Alabama. (51.2)
P81
Lymphocyte Response Assay: Report on Precision of
Novel Cell Culture Test. A.E. Lynch, R. Jaffe. Hlth.
Studies Collegium, Ashburn, VA. (51.4)
P82
FLIM-FRET Imaging of Ligand-Receptor Binding in
Tumor Cells In Vitro and In Vivo. M.M. Barroso, A.
Rudkouskaya, S. Patel, N. Sinsuebphon, X. Intes.
Albany Med. Col. and Rensselaer Polytech Inst.
(51.7)
P83
How Different Are We? Performing Formalin Fixed
Paraffin Embedded Tissue Immunohistochemistry
across Species. K.N. Gibson-Corley, G. OforiAmanfo, M.R. Leidinger, A.M. Lambertz. Univ. of
Iowa. (51.6)
TUESDAYPATHOLOGY
P84
R-Ras Subfamily Proteins Elicit Distinct Physiologic
Effects and Phosphoproteome Alterations in
Neurofibromin-Null MPNST Cells. A. Prechtl, N.
Brossier, S. Barnes, L. Wilson, S. Brosius, S. Byer,
S. Carroll. Med. Univ. of South Carolina and Univ. of
Alabama, Birmingham. (1179.8)
111
P85
In-DANBIRT as an In Vivo SPECT/CT Imaging Tool for
the Expression of LFA-1 in the Inflammatory Process
of Atheroma Development. R.I. Mota, T. Daniels, M.
Nysus, S. Lucas, J. Norenberg, M. Campen. Col. of
Pharm., Univ. of New Mexico. (1177.22)
P86
A Novel Bioinspired Microfluidic Assay for Investigation
of the Role of Protein Kinase C-Delta in Human
Neutrophil-Endothelium Interaction during Acute
Inflammation. F. Soroush, Y. Tang, P. Pandian, L.E.
Kilpatrick, M.F. Kiani. Temple Univ. and CFD Res.
Corp., Huntsville, AL. (1177.3)
P87
Fenofibrate Induces Cardiac Fibrosis in Mice Lacking the
Co-chaperone and E3-Ubiquitin Ligase CHIP. S. Ravi,
M.S. Willis, P. Lockyer, C. Patterson, J.C. Schisler.
Univ. of North Carolina at Chapel Hill. (306.8)
P88
Hydroxylase Inhibition Reduces Transforming Growth
Factor-β1-Induced Fibrosis Associated with Colitis.
M. Manresa, M. Tambuwala, P. Radhakrishnan,
J. Harnoss, M. Cavadas, C. Keogh, A. Cheong,
E. Cummins, K. Barrett, M. Schneider, C. Taylor.
Univiversity Col. Dublin, Univ. of Heidelberg, Systs.
Biol. Ireland, Dublin and UCSD. (444.8)
P89 Prostaglandin E2 Inhibits Monocyte Chemotactic
Protein 5 Production and Secretion in Mouse Cardiac
Fibroblasts via EP4 Receptor. T.D. Bryson, D.
Szandzik, P. Harding. Henry Ford Hlth. Syst. and
Wayne State Univ. Sch. of Med. (306.9)
P90
CD36-Myeloperoxidase Connection and the Activation
of Intestinal Fibroblasts. M. Anderson-Thomas, A.
Nillas, T.A. Reaves. Med. Univ. of South Carolina.
(922.1)
P91 Amphiregulin Promotes Fibroblast Activation in
Pulmonary Fibrosis. T. Liu, F. Gonzalez De Los
Santos, L. Ding, Z. Wu, S.H. Phan. Univ. of Michigan.
(50.6)
P92
R-Spondin2 Is Upregulated in Idiopathic Pulmonary
Fibrosis and Affects Fibroblasts Behavior. A.
Munguia, C. Becerril, C. Mendoza, Y. Balderas, R.
Ramirez, J. Melendez, A. Pardo, M. Selman. Biol.
Sci., Natl. Inst. of Resp. Dis., Fac. of Sci. and Natl.
Inst. of Genomic Med., UNAM, Mexico City. (50.7)
P93
TGF-Beta Induces the Expression of Scleraxis in Lung
Fibroblasts from Idiopathic Pulmonary Fibrosis.
M. Ramirez Aragon, M.A. Blancas Oropeza, F.
Hernandez Sanchez, A. Cruz Lagunas, M.P.
Czubryt, C. Mendoza Milla. UNAM and INER,
Mexico City and Inst. of Cardiovasc. Sci., Winnipeg,
Canada. (700.4)
P94 Extracellular
Vesicles
Isolated
from
Human
Mesenchymal Stem Cells Promote Resolution
of Pulmonary Fibrosis. T.P. Shentu, S. Wong, C.
Espinoza, M. Cernelc-Kohan, J. Hagood. UCSD
and Rady Hosp. of San Diego. (160.2)
P95
Role of Post-translational Modifications In Prion Strain
Diversity. P. Aguilar-Calvo, C. Bett, H. Eraña, J.
Castilla, P. Nilsson, C. Sigurdson. UCSD, CIC
bioGUNE, Spain and Linköping Univ., Sweden.
(518.1)
P96
The Biophysical Determinants of Prion Neuroinvasion.
C. Sigurdson, J. Lawrence, C. Bett, T. Kurt, C. Wu,
W. Surewicz, K.P.R. Nilsson. UCSD, Case Western
Reserve Univ. and Linköping Univ., Sweden. (518.2)
P97 The Molecular Basis for Cross-Species Prion
Transmission. T. Kurt, L. Jiang, N. Alderson, J. Liu,
D. Eisenberg, C. Sigurdson. UCSD and UCLA.
(814.7)
P98
AA Amyloidosis in Island Foxes (Urocyon littoralis):
Pathology, Risk Factors, and the Genetic Basis
for Disease. P. Gaffney, C. Witte, D. Clifford, M.
Ghassemian, T. Gaasterland, C. Sigurdson. UCSD,
Zool. Soc. of San Diego, Escondido and California
Dept. of Fish and Wildlife, Rancho Cordova. (445.4)
P99 Caveolin-1 Regulation of DISC1 as a Potential
Therapeutic Target for Schizophrenia. A. Kassan, J.
Egawa, Z. Zhang, Y. Lajevardi, K. Kim, Q.M. Nguyen,
E.S. Posadas, A. Sawada, D.V. Jeste, D.M. Roth,
P.M. Patel, H.H. Patel, B.P. Head. UCSD. (518.3)
P100 Role of Hippocampal Neurogenesis in Drug Addiction.
R.J. Morales Silva, M.H. Galinato, C. Mandyam.
Univ. of Puerto Rico, Ponce and The Scripps Res.
Inst. (518.4)
P101 Effect of Stabilizing Alpha Synuclein-Membrane
Interactions on the Protein’s Aggregation and
Neurotoxicity. D. Ysselstein, V. Mishra, G. McCabe,
J-C. Rochet. Purdue Univ. (518.7)
P102
How the γPKC Activity Is Regulated in Neurodegenerative
Spinocerebellar Ataxia Type 14. N. Aslam, F. Alvi.
BioSystOmics, Houston and COMSAT, Lahore.
(1179.3)
P103Ryanodine
Receptor-Dependent
Modulation
of
Experimental Autoimmune Encephalomyelitis in
Mice. N.C. Osipchuk, A. Soulika, L. Cruz-Orengo,
P.D. Allen, A.F. Fomina. Univ. of California, Davis.
(1179.6)
P104 Regeneration of Large-Gap Peripheral Nerve Injuries
Using Acellular Nerve Allografts Plus Amniotic Fluid
Derived Stem Cells. X. Ma. Wake Forest Univ.
(1179.7)
P105 Effect of Disrupted Insulin and IGF-1 Signaling on the
Pro-apoptotic and Anti-proliferative RhoGAP, Porf-2.
Q.V. Luong, W. Zhang, J. Pessia, Z. Wang, Y. Zhang,
Y. Slyvka, F. Nowak. Ohio Univ. (1179.13)
P106 Neonatal and Juvenile Ocular Development in SpragueDawley Rats: A Histomorphological Study. V. Vrolyk,
A. Apreutese, C. Gordon, R. Forster, A. Graham,
B. Palate, J. Haruna, M-O. Benoit-Biancamano.
Fac. of Vet. Med., Univ. of Montreal, St. Hyacinthe
and CiToxLAB, Laval, Canada and Evreux, France.
(1179.14)
P107 Immunohistochemical Detection of Autophagy-Related
Proteins in Canine Appendicular Osteosarcoma.
C.R. Schott, G.A. Wood. Ontario Vet. Col., Guelph.
(920.11)
P108 Use of Hepatic Gene Expression Analysis to Investigate
Iron Accumulation in Rats Treated with an RGMc
Antagonist Monoclonal Antibody. M.J. Liguori, P.
Boeser, L. Fan, L. Huang, D. Seemann, E.A.G.
Blomme, A. Popp, B.K. Mueller. AbbVie, North
Chicago, Abbvie Deutschland GmbH & Co.,
Ludwigshafen and AbbVie Biores. Ctr., Worcester.
(1180.3)
137
T
U
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PATHOLOGY/ PHARMACOLOGY
TUESDAY
P109
Echinacea purpurea Down Regulates LPS-Induced
Expression of Pro-inflammatory and Angiogenic
Factors in an Ex Vivo Model of Equine Placentitis.
C. Sloboda, S. Chico, J. Gordon, S. Bailey, K.A.
Zwetsloot, C. Mowa. Appalachian State Univ. and
North Carolina State Univ. Vet. Sch. (921.3)
P110 Synonymous Codon Changes in Measles (HMV)
and Canine Distemper (CDV) Viral Nucleic Acid
Sequences Result in Gene-Specific Changes in
Levels of Viral Protein Expression. E.W. Uhl, M.L.
Osborn, F.J. Michel, R.J. Hogan. Univ. of Georgia.
(517.4)
P111
Analysis of Forces Acting on the Equine Navicular Bone
in Normal and Dorsiflexed Positions. K.C. Ruff, M.L.
Osborn, E.W. Uhl. Univ. of Georgia. (923.4)
P112 Upregulation of Chemokine Ligands and Receptors
in the Spinal Cord of Type 2 Diabetic Monkeys.
N. Kiguchi, H. Ding, C.M. Peters, N.D. Kock, S.
Kishioka, J.D. Wagner, J.M. Cline, M-C. Ko. Wake
Forest Sch. of Med. and Wakayama Med. Univ.,
Japan. (921.6)
P113
P114
P115
P116
P117
Kinetics and Implications of Germinal Center Formation
in Induced Bronchus-Associated Lymphoid Tissue
during Influenza Infection. K.N. Gibson-Corley, A.W.
Boyden, L. Tygrett, T.J. Waldschmidt. Univ. of Iowa.
(700.5)
Identification of Protein Kinase R and Tissue Distribution
in Channel Catfish. J. Ball, M. Vides, Y. Kobayashi.
Fort Hays State Univ., KS. (925.3)
Biologic Potency Variation among Bovine, Ovine and
Porcine Heparins May Be Due to Their Differential
Affinity to Antithrombin. Y. Yao, O. Bouchard, S.
Abro, D. Kahn, D. Hoppensteadt, J. Fareed. Ronnsi
Pharma Co. LTD, China and Loyola Univ. Med. Ctr.
(1177.11)
Pulmonary Dipeptidyl Peptidase-4 Expression in Lung:
Relevance in Experimental Models and for Middle
East Respiratory Syndrome Clinical Disease. D.K.
Meyerholz, P.B. McCray; Jr. Univ. of Iowa Carver
Col. of Med. (700.7)
A Comparison of Ovine and Porcine Heparins and
Enoxaparins: A Case for an Alternative Source of
Heparin Products. O. Bouchard, S. Abro, D. Kahn,
O. Iqbal, D. Hoppensteadt, Y. Yao, J. Fareed. Loyola
Univ. Med. Ctr. (1177.5)
Pharmacology
448. RHOA IN FOCUS: PATHWAYS
FROM GPCRS TO DISEASE
Lecture
(Sponsored by: The Divisions for Cardiovascular
Pharmacology and Molecular Pharmacology)
11:30
S. Miyamoto. UCSD.
GPCR and RhoA Signaling in Hypertension. C.P. Mack.
Univ. of North Carolina Sch. of Med..
450. CENTRAL MECHANISMS CONTRIBUTING TO
NOVEL ANTIDEPRESSANT EFFICACY
Symposium
Pharmacology, Translational and Clinical Pharmacology,
and Behavioral Pharmacology )
8:30Introduction.
8:35
RhoA in Focus: Pathways from GPCRs to Disease.
J.H. Brown. UCSD.
449. GPCR AND RHOA AS MEDIATORS OF DISEASE
Chaired: D. Lodge
Neuropharmacology
Symposium
(Sponsored by: The Divisions for Cardiovascular
Pharmacology and Molecular Pharmacology)
Cochaired: R. Neubig and S. Miyamoto
Cancer Biology
9:30
GPCR and RhoA Signaling in Fibrosis. R. Neubig.
Michigan State Univ.
10:00 GPCR and RhoASignaling in Cancer. J.S. Gutkind. UCSD.
10:30 GPCR and RhoA Signaling in the Nervous System.
X. Piao. Boston Children’s Hosp.
11:00 GPCR and RhoA Signaling in Cardioprotection.
138
Neurobiology
9:30Introduction.
9:35 Antidepressant Efficacy of Ketamine in Depressed
Patients. G. Sanacora. Yale Univ.
10:00 The vHipp-mPFC Pathway Mediates the Sustained
Antidepressant Response to Ketamine. D. Lodge.
Univ. of Texas Hlth. Sci. Ctr., San Antonio.
10:25 Development of Prophylactics Against Stress-induced
Depressive-like Behavior. C.A. Denny. Columbia Univ.
10:50 BDNF Receptor Signaling is Differentially Altered by
Novel Antidepressants. F. Carreno. Univ. of Texas
Hlth. Sci. Ctr., San Antonio.
11:15 Evaluation of Molecular Biomarkers in an Adolescent
Chronic Restraint Stress Model of Depression.
M. Graham, M. Hibicke, R. Hayslett. Mercer Univ.
Col. of Pharm. (929.3)
TUESDAYPHARMACOLOGY
11:30 Chronic Isolation Stress Alters Antidepressant-Like
Behaviors in Animals Lacking RGS4. J.N. Talbot, B.
Poncede Leon, C.M. Benhatzel, C.L. Nielsen, D. Alp,
R. Kirsh, J.R. Traynor. Roseman Univ. of Hlth. Sci., Touro
Univ. Nevada, Roseman Univ. of Hlth. Sci. Cols. of Pharm.
and Med., and Univ. of Michigan Med. Sch. (929.6)
11:45 General Discussion.
451. CHRONOPHARMACOLOGY IN CANCER:
DOES TIME REALLY MATTER?
Symposium
(Sponsored by: The Division for Cancer Pharmacology)
(Cosponsored by: The Divisions for Drug Metabolism and
Pharmacology Education )
Chaired: S. Gaddameedhi
Cancer Pharmacology
Cancer Biology
9:30Introduction.
9:35
Chronopharmacology: Temporal Targets of Drug Action
and Therapeutic Implications. J. Hogenesch. Univ.
of Pennsylvania.
10:05 Unraveling the Potential of Chronopharmacology through
Genotoxic Stress Mediated Anti-cancer Drug Effect in
Cancer. S. Gaddameedhi. Washington State Univ.
10:35 Tamoxifen Resistance in Breast Cancer: The Melatonin
Connection. S.M. Hill. Tulane Univ. Sch. of Med.
11:05 Cancer Chronotherapy: Clinical Perspectives and
Outcomes. F. Lévi. Warwick University, UK.
11:35 A Multi-scale Systems Pharmacology Approach for
Personalizing Irinotecan Chronotherapy. A. Ballesta, S.
Dulong, R. Dallmann, P. Innominato, F. Lévi. Univ. of
Warwick, U.K. and INSERM Unit 935, Villejuif. (712.2)
452. NICOTINIC AGONIST/ANTAGONIST DRUG
DEVELOPMENT: IMPLICATIONS FOR
TREATMENT OF NEURODEGENERATIVE AND
ADDICTIVE DISORDERS
Symposium
9:55
Nicotinic Receptors as Targets for Treating Parkinson’s
Disease: Relevance to Parkinson’s Disease Therapy.
T. Bordia. SRI Intl.
10:20 Nicotinic Receptors as Targets for Treating Alzheimer’s
Disease. K. Dineley. Univ. of Texas, Med. Branch.
10:45 Nicotine and Interoceptive Conditioning: Implications
for Treating Nicotine Dependence. R. Bevins. Univ.
11:10 Acute Tolerance to the Discriminative Stimulus Effects
of Nicotine in Monkeys. M.J. Moerke, L. McMahon.
Univ. of Texas Hlth. Sci. Ctr. at San Antonio. (1187.2)
11:35 A Novel Structural Landscape for Ligand Binding to the
α7 Nicotinic Acetylcholine Receptor. G.A. CamachoBustamante, K. Kaczanowska, M. Harel, J. CornejoBravo, P. Taylor. UCSD and Univ. Autonomous de
Baja California, Tijuana. (1187.9)
453. PATIENT-SPECIFIC STEM CELLS AS
MODELS FOR GENE-DISEASE, DRUG, AND
ENVIRONMENT INTERACTIONS
Symposium
Translational and Clinical Pharmacology, and Drug
Discovery and Development )
Chaired: J.R. Richardson
Toxicology
Neurobiology
9:30Introduction.
9:35
Modeling Gene-Environment Interactions in Alzheimer
Disease. J.R. Richardson. Northeast Ohio Med. Univ.
10:05 Alterations of Manganese Biology in Huntington’s
Disease. A. Bowman. Vanderbilt Univ.
10:35 Stem Cells in Inorganic Carcinogenesis. E. Tokar.
NIEHS, NIH.
11:05 Leveraging Novel Technologies for Human iPSC-based
Screening for Parkinson’s Disease. X. Zeng. The
Buck Inst.
Molecular Pharmacology, Drug Discovery and Development,
and Translational and Clinical Pharmacology)
Cochaired: A. Fleckenstein and M. Quik
Neurobiology
9:30
Chronic Nicotine Protects Against MethamphetamineInduced Behavioral and Dopaminergic Deficits.
A. Fleckenstein. Univ. of Utah.
139
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PHARMACOLOGYTUESDAY
454. CURRENT TRENDS IN ANTIBODY DRUG
CONJUGATES: FROM DISCOVERY TO THE CLINIC
Symposium
(Sponsored by: The Divisions for Drug Discovery and
Development and Drug Metabolism)
Pharmacology, Cancer Pharmacology, and Translational
and Clinical Pharmacology )
Cochaired: T. Esbenshade and L.C. Wienkers
3:50
4:10
456. DIVISION FOR TOXICOLOGY SYMPOSIUM:
FORTUITOUS PROTEIN MODIFICATION IN
DISEASE PATHOGENESIS AND TREATMENT
Division Symposium
Drug Metabolism
Cancer Biology
9:30Introduction.
9:35
Advances in Drug-Linker Design to Improve the Stability,
Homogeneity, and Pharmacokinetics of AntibodyDrug Conjugates. R.P. Lyon. Seattle Genetics.
10:05 Considerations for ADC Catabolism and Catabolite
Disposition. D. Rock. Amgen, Inc.
10:35 Analysis of Antibody-Auristatin Conjugates for Cancer
Therapy. S. Hengel. Seattle Genetics.
11:05 Leveraging Clinical Learnings and Patient Tailoring to
Enable Next Generation Conjugate Success: Hsp90
Inhibitor Drug Conjugates (HDCs). A.C. Rigby. Synta
Pharmaceut. Inc.
11:35Discussion.
455. DIVISION FOR CARDIOVASCULAR
PHARMACOLOGY TRAINEE SHOWCASE
2:30
2:50
3:10
3:30
140
MSC Exosomes Deliver Cardioprotective miR-21. K.
Luther, M. McGuinness, L. Haar, H. Xu, J. Chen,
M. Medvedovic, W.K. Jones. Loyola Univ. Chicago
Maywood and Univ. of Cincinnati. (719.1)
Human Perivascular Adipose Tissue Contains an
Adrenergic System. N. Ayala-Lopez, C. PereiraHicks, R. Burnett, G.D. Fink, S.W. Watts. Michigan
Chaired: S.S. Lau
Toxicology
3:00Introduction. S.S. Lau. Wayne State Univ.
3:05 Characterization of Blood Protein Adducts Formed
with Cooked Meat Carcinogens and Approaches of
Human Biomonitoring by Ion Trap Mass Spectrometry.
R. Turesky. Univ. of Minnesota.
3:35
Dopamine Adduction to α-Synuclein and Parkinson’s
Disease. T. Monks. Univ. of Arizona.
4:05 Visual Cycle Adducts and Diseases of Retina.
J. Sparrow. Columbia Univ.
4:35
Dicarbonyl Protein Modification, Diabetic Complications
and Metformin Therapy. S.S. Lau. Wayne State Univ.
5:00 Wide-Spread
Insulin
Resistance
in
Tyrosine
Phosphorylation in Type 2 Diabetic Patients. Z. Yi.
Wayne State Univ.
457. DIVISION FOR DRUG DISCOVERY
AND DEVELOPMENT SYMPOSIUM:
CHEMICAL BIOLOGY AS AN ENGINE FOR
DRUG DISCOVERY
Cochaired: C. McCarthy and J. Schilling
Division Symposium
and Development)
Inhibiting Fibronectin Improves Cardiac Function in a
Mouse Model of Heart Failure. I. Valiente Alandi,
M. Nieman, J.D. Molkentin, B.C. Blaxall. Cincinnati
Children’s Hosp. Med. Ctr. and Univ. of Cincinnati.
(939.2)
Kruppel-Like Factor 15: A Critical Transcriptional
Regulator of Hypoxia Induced Endothelial Arginase 2.
D. Pandey, D. Hori, L. Santhanam, D. Berkowitz, L.
Romer. Johns Hopkins Univ. Sch. of Med.
Nanogel Drug Carriers Presenting Platelet GPIb[alpha]
Mimic and Enhance Platelet Adhesion. J.W. Myerson,
I. Johnston, J. Wu, R. McClintock, Z. Ruggeri, M.
Poncz, V. Muzykantov. Univ. of Pennsylvania and
The Scripps Res. Inst.
Reversal of Stem Cell Mobilopathy and Enhanced
Vascular Repair by Angiotensin-(1-7) in Diabetes.
G. Vasam, Y. Jarajapu. North Dakota State Univ.
(1270.2)
Cochaired: J.S. Lazo and C. Beeson
3:00
3:05
3:40
4:15
4:50
Introduction to the Symposium. J. Lazo. Univ. of Virginia
Sch. of Med.
Developing Novel Chemical Biology Strategies to
Synthetically Disrupt Protein:Protein Interactions.
E.J. Kennedy. Univ. of Georgia.
Developing Drug-like Molecules that Alter Important
Biological Processes. M. Arkin. Univ. of California,
San Francisco.
Targeted Protein Degradation – What it Provides and
How to Achieve It. C.M. Crews. Yale Univ.
Precision Biosynthesis of Natural Product Drug Leads.
B. Moore. UCSD.
TUESDAYPHARMACOLOGY
5:25
Summary and Concluding Remarks. C. Beeson. Med.
Univ. of South Carolina.
459. DIVISION FOR NEUROPHARMACOLOGY
POSTDOCTORAL SCIENTIST AWARD FINALISTS
458. DIVISION FOR CANCER PHARMACOLOGY:
CELL SIGNALING IN CANCER BIOLOGY
AND THERAPEUTICS
Neuropharmacology
Neurobiology
Cochaired: R.K. Guy and J.C. Yalowich
Cancer Pharmacology
Cancer Biology
3:00Introduction/Overview. R.K. Guy. St. Jude Childrens
Res. Hosp.
3:05 Proteinases, Proteinase-Activated Receptors and
Transient Receptor Potential Ion Channels:
Driving Tumorigenesis in the Bladder Cancer
Microenvironment. S. Gibson, K. Mihara, M. El-Daly,
M. Saifedine, M.D. Hollenberg, M.E. Hyndman. Univ.
of Calgary, Snyder Inst. for Chronic Dis., Cumming Sch.
of Med. and Prostate Cancer Ctr., Calgary. (714.2)
3:25
Epac1 Links Prostaglandin E2 to β-Catenin Transcriptional
Activity during Epithelial-to-Mesenchymal Transition in
A549 Cells. S. Jansen, W. De Jager, S.J. Yarwood,
F. Lezoualc’h, R. Gosens, M. Schmidt. Univ. of
Groningen, Netherlands, Univ. of Glasgow, U.K. and
Univ. Toulouse III, France. (714.5)
3:45
Electrophilic Nitroalkenes Inhibit Triple Negative Breast
Cancer Metastasis. C-S. Woodcock, S.R. Woodcock,
C. Cao, N.E. Davidson, Y. Huang, B.A. Freeman.
Univ. of Pittsburgh, Sch. of Med. and Univ. of Pittsburgh
Cancer Inst. (714.7)
4:05Break
4:25 Treatment of Triple Negative Breast Cancer-Derived
Cells with Polyisoprenylated Cysteinyl Amide
Inhibitors Activates Caspase 3/7 and Disrupts F-Actin
Organization Leading to Apoptosis and Diminished Cell
Motility. O. Salako, R. Poku, A. Nkembo, F. Amissah,
E. Ntantie, N. Lamango. Florida A&M Univ. Col. of
Pharm. & Pharmaceut. Sci. (936.3)
4:45
A Dock-Derived PEDF Mimic Targeting Laminin Receptor
Downregulates VEGF Receptor. C.S. Umbaugh, A.
Diaz-Quiñones, M. Figueiredo. Purdue Univ. and
Univ. Central del Caribe Med. Sch., PR. (936.5)
5:05
Synergism between Bioengineered miR-34a Prodrugand
Doxorubicin in Suppressing Osteosarcoma cell
Proliferation and Xenograft Tumor Growth. M. Tu,
Y. Zhao, Y. Yu, W. Wang, Q. Chen, J. Qiu, A. Yu, A. Yu.
Univ. of California Davis, Sacramento, Wuhan Univ.,
China and Univ. of Buffalo. (936.1)
3:00
Path to Becoming a Neuropharmacologist and the
Search for Novel Psychotherapeutic Drug Targets.
L.C. Daws. Univ. of Texas Hlth. Sci. Ctr.
3:45 Chronic Cocaine Exposure Alters D1 Medium Spiny
Neuron Activity to Promote Relapse. E.S. Calipari,
R.C. Bagot, I. Purushothaman, S. Pirpinias, T.J.
Davidson, K. Deisseroth, E.J. Nestler. Icahn Sch. of
Med. at Mount Sinai and Stanford Univ. (1186.2)
4:00
Chronic Antagonism of p38α MAPK Normalizes Serotonin
Clearance, Serotonin Receptor Hypersensitivity and
Social Behavior Deficits in a Genetic Murine Model
of Autism Spectrum Disorder. M.J. Robson, M.A.
Quinlan, J. Veenstra-VanderWeele, D.M. Watterson,
R.D. Blakely. Vanderbilt Univ., Columbia Univ. and
Northwestern Univ., Chicago. (707.9)
4:15 Cocaine-Induced
Chromatin
Modifications
Are
Associated with Increased Gene Expression and
DNA-DNA Interactions of AUTS2. O. Engmann, B.
Labonte, A. Mitchell, E. Calipari, J. Rabkin, Y. Hurd,
G. Turecki, S. Akbarian, E.J. Nestler. Icahn Sch. of
Med. at Mount Sinai and McGill Univ. (1186.3)
4:30 Rapid Antidepressant-Like Effects of the “Uptake-2”
Blocker, Decynium 22 in the Flinders Sensitive Line
Rat Model of Depression. R. Fraser-Spears, W.A.
Owens, N.C. Mitchell, D. Overstreet, W. Koek, L.C.
Daws. Univ. of Texas Hlth. Sci. Ctr. at San Antonio
and Univ. of North Carolina at Chapel Hill. (929.7)
4:45
Impact of Chronic Ethanol Self-Administration on Kappa
Opioid Receptor Regulation of Dopamine Signaling in
Nonhuman Primates. C.A. Siciliano, E.S. Calipari,
S.C. Fordahl, J.R. Melchior, J.T. Yorgason, Y. Mateo,
C.M. Helms, V.A. Jimenez, D.M. Lovinger, K.A. Grant,
S.R. Jones. Wake Forest Sch. of Med., NIAAA, NIH,
Rockville and Oregon Hlth. & Sci. Univ. (704.1)
5:00
GPR171 in the Basolateral Amygdala Regulates Stress
and Reward-Related Behaviors. E. Bobeck, D. Pena,
I. Gomes, W. Fujita, L. Devi. Icahn Sch. of Med. at
Mount Sinai. (1265.9)
5:15Discussion.
141
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PHARMACOLOGY/PHYSIOLOGYTUESDAY
460. PAUL M. VANHOUTTE DISTINGUISHED
LECTURESHIP IN VASCULAR PHARMACOLOGY
Award Lecture
The Paul M. Vanhoutte Award in Vascular Pharmacology
was established to honor Dr. Vanhoutte’s lifelong scientific
contributions to our better understanding and appreciation
of the importance of endothelial cells and vascular smooth
muscle function in health and disease and for his mentoring
of countless prominent endothelial and vascular biologists
and pharmacologists.
4:30Introduction.
4:35
Capillaries as Decoders of the Neural Rhythm of the
Brain: Translating Thought into Blood Flow. M.
Nelson. Univ. of Vermont.
Physiology
PHYSIOLOGICAL ADAPTATION TO
BEHAVIORAL, ENVIRONMENTAL, AND
CHRONOLOGICAL STRESS
Symposium
Ballroom 20A
9:30
9:45
463. A BROAD HISTORY OF
TEMPERATURE REGULATION
Symposium
Chaired: L. Simon and A.M. Whitaker
(Sponsored by: APS History of Physiology Group)
10:30 Adaptation to High Altitude. T. Simonson. UCSD.
11:00 Human Heat Acclimation. M. Sawka. Georgia Inst.
of Technol.
11:30 Responses of Quiescent Stem Cells to Systemic
Signals. T. Rando. Stanford Univ. Med. Ctr.
12:00 Sympathoneural and Adrenomedullary Responses to
Mental Stress. D. Goldstein. NINDS, NIH.
462. 2016 GABOR KALEY LECTURE
FEATURED TOPIC
Featured Topic
(Sponsored by: APS Cardiovascular Section and The
Microcirculatory Society)
Chaired: L.R. Leon and S. Kirkton
8:00
Hypothalamic Control Mechanisms of Temperature
Regulation. G. Mack. Brigham Young Univ.
8:30
Temperature Regulation in Ectotherms. L. Crawshaw.
Portland State Univ.
9:00
From Beer Cans to Intelligent Agents: the Evolution of
an Evolutionary Theory of Thermoregulation and Its
influence on Global Change Biology. M. Angilletta.
Arizona State Univ.
9:30 Physiological Mechanisms of Heat Acclimation.
S. Schneider. Univ. of New Mexico.
464. ADVANCES IN RENAL PHYSIOLOGY II
Chaired: S. Nourshargh
8:00
8:50
9:15
142
Neutrophil-Microvessel Interactions: Novel Concepts
and Pathophysiological Implications. S. Nourshargh.
Queen Mary, Univ. of London.
Circadian Rhythms in Leukocyte Recruitment to
Tissues. C. Scheiermann. Ludwig Maximilians Univ.
Munich. (1210.1)
High Affinity Bent β2 Integrin Binds Ligand in Cis and
Regulates Inflammation. Z. Fan, S. McArdle, Z.
Mikulski, E. Gutierrez, M. Ginsberg, A. Groisman,
K. Ley. La Jolla Inst. for Allergy and Immunol. and
UCSD. (1210.2)
Soluble Vimentin Decreases Neutrophil Adhesion
to Platelets by Inhibiting P-Selectin Glycoprotein
Ligand-1-P-Selectin Interactions. F.W. Lam, Q. Da, M.
Cruz, C.W. Smith. Baylor Col. of Med. and Michael E.
DeBakey VA Med. Ctr., Houston. (1210.4)
Endothelial Cell Secreted MIF Regulates Pericyte
Contractility to Decrease Barrier Function. A. Pellowe,
Y. Hou, M. Harris, R. Liu, J.S. Pober, A. Gonzalez.
Yale Univ. (1210.6)
Featured Topic
Chaired: P. O’Connor and L. Evans
Ion Transport
8:00
The Role of the NADPH Oxidase Subunit p67phox in the
Regulation of Renal Blood Flow in Dahl S (SS) Rats.
L.C. Evans, A.J. Polichnowski, A.W. Cowley Jr.
Med. Col. of Wisconsin and Loyola Univ. and Hines
VA Hosp., Maywood, IL. (739.7)
TUESDAYPHYSIOLOGY
8:15
Bicarbonate Therapy Has No Effect on Renal T-Cell
Infiltration or Blood Pressure but Markedly Reduces
Tubular Casts/Fibrosis and Is Associated with an
M1 to M2 Polarization in Dahl Salt-Sensitive Rats.
P. O’Connor, J-K. Chen, L. Taylor, S. Ray, B. Baban,
J.C. Sullivan. Georgia Regents Univ. (966.8)
8:30 Alstrom Syndrome 1, a New Interacting Protein of
NKCC2, Regulates Apical NKCC2 Trafficking, Urinary
Concentration and Blood Pressure. A.B. Jaykumar,
P. Caceres, G. Ares, W. Beierwaltes, P. Ortiz. Henry
Ford Hosp. and Wayne State Univ. (965.11)
8:45RORγt-Dependent Preferential Induction of IL-17F by
TLR3 Activation in SHR Immune Cells. M.V. Singh,
M.Z. Cicha, M.W. Chapleau, F.M. Abboud. Univ. of
Iowa and VA Med. Ctr. (966.7)
9:00 Intervention with VG1177, a MHC Class II Invariant
Peptide Chain Antagonist, Restores Afferent Arteriolar
Autoregulatory Behavior during Chronic 14 Day
Lipopolysaccharide Treatment. J.P. Van Beusecum,
A.K. Cook, S. Zhang, R.P. Tobin, K. Newell-Rogers,
E.W. Inscho. Univ. of Alabama at Birmingham and
Texas A&M Hlth. Sci. Ctr./Baylor Scott & White Hlth.
(966.5)
9:15
Renal Cortical Hydrogen Peroxide (H2O2) Stimulates
Renin Release from Juxtaglomerular (JG) Cells and
Increases Blood Pressure: Role of JG Cell NOX4.
M. Mendez. Henry Ford Hosp. (1218.7)
9:30 Formyl Peptide Receptor Blockade Ameliorates
Intrarenal Resistance Artery Function and Decreases
Blood Pressure in SHR. C.F. Wenceslau, C.G.
McCarthy, T. Szasz, S. Ogbi, R.C. Webb. Georgia
Regents Univ. (966.2)
9:45
Three-Layered Proteomic Characterization of a Novel
ACTN4 Mutation Reveals Its Pathogenic Potential in
FSGS. M.M. Rinschen, M. Bartram, T. Benzing, B.B.
Beck. Univ. Hosp. Cologne. (1220.1)
465. BEYOND GWAS: ATTACHING PHYSIOLOGY TO
THE GENOME
466. BUILDING NEURAL CIRCUITS: WIRING
AND EXPERIENCE
Symposium
Chaired: S.D. Van Hooser and J. Cang
Neurobiology
Neurophysiology
8:00
8:30
9:00
9:30
467. JOHN FORTE GIL SECTION DISTINGUISHED
ABSTRACT PLENARY SESSION
Featured Topic
Physiology Section)
Chaired: J. Uno and Y. Zavros
8:00
8:15
Symposium
(Sponsored by: Physiological Genomics Journal)
8:30
Tue. 8:00 am—San Diego Convention Center, Ballroom 20A
Chaired: P. Munroe and T. Wiltshire
8:00
8:30
9:00
9:30
Challenges of Interpreting GWAS Variants to Function.
P. Munroe. Queen Mary Univ. of London.
Utility of Model Systems for Functional Testing and
Physiology. B. Joe. Univ. of Toledo Coll. of Medicine.
Translational of GWAS Findings to the Clinic.
S. Padmanabhan. Glasgow Univ.
Cardiovascular Pharmacogenetics. T. Wiltshire. Univ.
of North Carolina at Chapel Hill.
Choosing Which Way to Go: Development of Direction
Selectivity in Visual Cortex. S.D. Van Hooser.
Brandeis Univ.
Binocular Matching and Critical Period Plasticity in the
Mouse Visual Cortex. J. Cang. Northwestern Univ.
Molecules and Mechanisms that Assemble Functionally
Specialized Visual Pathways. A. Huberman. Univ. of
California, San Diego.
Experience-Dependent Development of Visual Circuitry
in Xenopus. H. Cline. Scripps Res. Inst.
8:45
9:00
9:15
Sex Differences in GABAergic Neurotransmission to
Gastric-Projecting DMV Neurons. Y. Jiang, M.P.
D’Angelo, L. Anselmi, R.A. Travagli. Penn State Col.
of Med. and Univ. of Pittsburgh. (1254.4)
Involvement of TFF2 and Na/H Exchanger in Gastric
Wound Repair In Vitro in Gastric Organoids. K.A.
Engevik, A.L. Matthis, E. Aihara, M.H. Montrose.
Univ. of Cincinnati. (1250.5)
Cardiorespiratory Fitness as a Predictor of Intestinal
Microbial Diversity and Distinct Metagenomic
Functions. M. Estaki, J. Pither, P. Baumeister, J.P.
Little, S. Gill, S. Ghosh, Z. Ahmadi-Vand, K.R.
Marsden, D.L. Gibson. Univ. of British Columbia
Okanagan. (1027.5)
Activation of Nlrp3 Inflammasomes in Mouse Hepatic
Stellate Cells during Schistosoma J. Infection.
N. Meng, M. Xia, P-L. Li, W-X. Tang. Virginia
Commonwealth Univ. and Tongji Med. Col., Huazhong
Univ. of Sci. and Technol., China. (1024.1)
Blocking NF-κB Activation in Intestinal Lysozyme M
Positive Cells Prevents the NEC-Induced Decrease
in Ly6C Positive Cells in the Neonatal Intestine.
E. Managlia, X. Yan, X. Liu, J. Mangrum, I. De Plaen.
Ann & Robert H. Lurie Children’s Hosp. of Chicago
and Northwestern Univ., Chicago. (1023.6)
Regulation of the Antioxidant Glutathione by Enteric Glia
during Inflammation. I.A.M. Brown, B.D. Gulbransen.
Michigan State Univ. (1023.7)
143
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PHYSIOLOGYTUESDAY
9:30
9:45
Nonalcoholic Fatty Liver Disease Is Associated with
Dysfunction in Hepatic Circadian Rhythm. S. Larion,
J.D. Mintz, D.J. Fulton, S. Khurana, D.W. Stepp.
Med. Col. of Georgia. (1249.5)
Maternal High Fat Diet Increases an Inhibitory
Extrasynaptic Tonic GABAA Current in Dorsal Motor
Nucleus of the Vagus Neurons Regulating Gastric
Functions. C.A. McMenamin, K.N. Browning. Penn
State Col. of Med. (1252.5)
468. NEURAL CONTROL OF INFLAMMATIONMEDIATED HYPERTENSION
8:20
8:40
9:00
9:20
Neural and Cellular Mechanisms Mediating OpioidInduced Respiratory Depression and Strategies to
Reverse It. G. Montandon. Univ of Toronto.
Opioid Effects on Respiration- Data From Preclinical
Animal Models in Vivo. A. Stucke. Med. Col.
of Wisconsin.
How Opioids Interfere With Central Respiratory Control.
A. Garcia. Univ. of Washington Sch. of Med.
Ampakine Therapy for Opioid-induced Respiratory
Depression. J. Greer. Univ. of Alberta.
470. ORIGINS OF ADULT CARDIOVASCULAR AND
METABOLIC DISEASE
Featured Topic
Featured Topic
Regulation Section)
Chaired: E. Lazartigues
Chaired: A. Loria and E. Gillis
Neurobiology
Hypertension
8:00
8:30
9:00
9:15
9:30
9:45
Microglia Participate in Neurogenic Regulation of
Hypertension. P. Shi. Cedars-Sinai Med. Ctr.
Neuroimmune Pathway Critical in Development of
Hypertension. K. Mathis. Univ. of North Texas Hlth.
Sci. Ctr.
Defect Mitochondrial Biogenesis at Rostral Ventrolateral
Medulla in Neurogenic Hypertension under Peripheral
Inflammation. J.Y.H. Chan, K.L.H. Wu. Kaohsiung
Chang Gung Mem. Hosp., Taiwan. (1237.1)
Knockdown of Bradykinin B1 Receptor Reduces Neuroinflammation and Prevents the Development of SaltSensitive Hypertension. S. Sriramula, E. Lazartigues.
LSU Hlth. Sci. Ctr., New Orleans. (1237.4)
Cholinergic Stimulation of Immune Cells with Nicotine
Induces Renal Inflammation and Premature
Development of Hypertension in Young SHR.
S. Harwani, M. Chapleau, F. Abboud. Univ. of Iowa
and VA Med. Ctr. (1237.3)
Microglia Modulate Ang II-Induced Neuronal Activity and
Neuroinflammation. M.M. Santisteban, J. Zubcevic,
M. Febo, M.K. Raizada. Univ. of Florida. (1237.8)
469. OPIOID-INDUCED RESPIRATORY DEPRESSION:
SITES/MECHANISMS OF ACTION AND
POTENTIAL SOLUTIONS
Symposium
Chaired: H.V. Forster and J. Miller
Neurobiology
Neurophysiology
8:00
144
Opiod Effects on Respiratory Control in Diseased
States. A. Malhotra. UCSD.
8:00
Developmental Programming in Mouse, Monkey,
and Man: From Stem Cells to the Microbiome.
J. Friedman. Univ. of Colorado Sch. of Med. Anschutz
Medical Campus.
8:30 Leptin, Melanocortin 4 Receptor and Renal Nerves
Play a Role in High Blood Pressure Programmed by
Intrauterine Growth Restriction in Mouse. S. Intapad.
Univ. of Mississippi Med. Ctr. (1214.4)
8:45
Early-Life Stress Induces Increased Plasma Heme and
Toll-Like Receptor 4 Activation Leading to Increased
Superoxide Production in Aortic Endothelial Cells.
D.H. Ho, A.L. Ring, J.S. Pollock. Univ. of Alabama
at Birmingham and Tripler Army Med. Ctr., Honolulu.
(1214.2)
9:00
Influence of Activity before or during Pregnancy on Fetal
and Infant Heart Outcomes. L.E. May, O.R. Reoyo,
C.M. Moyer, E.R. Newton, D. Strickland. East
Carolina Univ., Tech Univ. of Madrid and Bridgewater
Col., VA. (1214.10)
9:15
Pulmonary and Systemic Vascular Responses in Rats
Exposed to Perinatal Hyperoxia. T.J. Greiner, D.
Rotella, M.L. Bates. Univ. of Iowa. (1214.11)
9:30 Increased Hepatic Lipogenic Gene Expression
Correlates with Enhanced Central and Ectopic
Adiposity in Female C57BL6 Mice Exposed to
Maternal Separation. M. Murphy, D. Cohn, C. Wills,
L. Gilbert, D. Powell, A. Loria. Univ. of Kentucky.
(1214.1)
9:45 Chronic Flutamide Treatment Alters Intrarenal Renin
Angiotensin System Expression in Intrauterine
Growth Restricted Female Rats. J.H. Dasinger, S.
Intapad, B.R. Rudsenske, B.T. Alexander. Univ. of
Mississippi Med. Ctr. (1214.5)
TUESDAYPHYSIOLOGY
471. REDOX MEDIATED ENDOTHELIAL
RESPONSES: SHOWCASING NOX2 ENZYMES
IN PATHOPHYSIOLOGY
Symposium
Featured Topic
Physiology Section)
Chaired: S. Chatterjee and V. Sampath
Oxidative Stress
8:00
8:30
9:00
9:30
473. CHRONIC LIVER DISEASES MODULATED
BY TRANSCRIPTIONAL AND
TRANSLATIONAL MECHANISMS
Endothelial NOX2 Signaling in Cardiovascular Disease.
K. Channon. Univ. of Oxford.
NOX2 in Cerebrovascular Dysfunction in Hypertension
and Alzheimer’s Disease. C. Iadecola. Weill
Cornell Inst.
Mechanosignal via Endothelial NOX2 Activation Triggers
inflammation During Donor Lung Preservation.
S. Chatterjee. Univ. of Pennsylvania.
Role of NOX2 in the Microvascular Dysfunction in Type
1 Diabetes Mellitus. K. Matrougui. Eastern Virginia
Sch. of Med.
472. SKELETAL MUSCLE PEROXISOMALMITOCHONDRIAL INTERACTIONS IN HEALTH
AND DISEASE
Featured Topic
Chaired: R. Cortright and R. Noland
8:00
Introduction to the Topic. R. Cortright. East Carolina Univ.
8:15 Peroxisomal-Mitochonrial interactions in Cardiac
Muscle. C. Hoppel. Case Western Reserve Univ.
9:00
Peroxisomes in Skeletal Muscle Protect against LipidInduced Insulin Resistance. R.C. Noland, E.A.
Worsham, J. Simon, S.E. Fuller, M. Baes, S. Ghosh,
R.L. Mynatt. Pennington Biomed. Res. Ctr., Baton
Rouge, Katholieke Univ. Leuven and Duke-Natl. Univ.
of Singapore Grad. Med. Sch. (1246.1)
9:15 Energy Sensing Pathways Differentially Regulate
Peroxisomes in Skeletal Muscle versus Liver. S.E.
Fuller, E.A. Worsham, J. Simon, T.W. Gettys, R.L.
Mynatt, R.C. Noland. Pennington Biomed. Res. Ctr.,
Baton Rouge. (1246.2)
9:30 Overexpression of PGC-1α Increases Peroxisomal
Biogenesis and Mitochondrial Lipid Oxidation in
Human Primary Myotubes. T-Y. Huang, D. Zheng, J.A.
Houmard, J.J. Brault, R.C. Hickner, R.N. Cortright.
East Carolina Univ., Diabetes Obesiy Inst. and Brody
Sch. of Med., Greenville, NC. (1246.3)
9:45Conclusion.
Chaired: L. Wang and K. Machida
10:30 LncRNA in Lipoprotein Metabolism. C. Wahlestedt.
Univ. of Miami Miller Sch. of Med.
11:00 Function of Non-Coding RNAs in Bile Acid
Homeostasis. L. Wang. Univ. of Connecticut Inst. for
Systs. Genomics.
11:30 The Critical Role of the G Protein-Coupled Receptor
30, a Novel Estrogen Receptor, in the Formation
of Lithogenic Bile through a Non-transcriptional
Regulatory Mode in 17β-Estradiol (E2)-Treated Mice.
D.Q. Wang, O. de Bari, H.H. Wang. Saint Louis Univ.
Sch. of Med. (1251.2)
11:45 TRPV4 Modulates CYP2E1 Function in Nonalcoholic
Steatohepatitis Progression. R.K. Seth, S. Das,
D. Dattaroy, F.A. Alhasson, G.A. Michelotti, M.
Nagarkatti, P. Nagarkatti, P.D. Bell, W.B. Liedtke,
A.M. Diehl, S. Chatterjee. Univ. of South Carolina,
Metabolon Inc., Durham, Univ. of South Carolina Sch.
of Med., Univ. of Alabama at Birmingham and Duke
Univ. (1251.3)
12:00 Chronic Alcohol Consumption Alters Rhythms in Key
Enzymes and Transcription Factors Involved in Lipid
Metabolism: Potential Role of the Circadian Clock.
J.A. Valcin, U.S. Udoh, T. Swain, S.M. Bailey. Univ.
of Alabama at Birmingham. (1251.1)
12:15 Mast Cells Promote Biliary Proliferation and Hepatic
Fibrosis in Normal and HDC-/- Mice by Interacting with
Cholangiocytes and Hepatic Stellate Cells via TGF-β1
Signaling. H. Francis. Central Texas VA Hlth. Care
Syst./Baylor Scott & White Hlth., Temple. (1251.4)
474. CONTEXT DEPENDENCE OF
CARDIORESPIRATORY PHYSIOLOGY:
TEMPERATURE EFFECTS, CIRCADIAN
CYCLES, AND SYSTEM INTERDEPENDENCE
Symposium
Physiology Section)
Chaired: J. Santin and L. Hartzler
Oxidative Stress
Neurobiology
10:30 Anurans as Research Models for Cardio-Respiratory
Physiology: Classic Questions and New Directions.
S. Hillman. Portland State Univ.
145
T
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PHYSIOLOGYTUESDAY
11:00
Temperature Effects on the Baroreflex in toads. L. Zena.
UNESP, Jaboticabal, Brazil.
11:30 Temperature Effects on Central Chemosensitivity in
Bullfrogs. J. Santin. Wright State Univ.
12:00 Orexin and the Modulation of Respiratory Control
in Ectothermic Vertebrates. E. Maioqui. UNESP,
Jaboticabal, Brazil.
477. LEADERSHIP AND MANAGEMENT SKILLS:
WHAT YOU MIGHT NOT SEE IN YOUR CV
Symposium
(Sponsored by: APS Careers Opportunities in
Physiology Committee)
475. ION CHANNELS AND TRANSPORTERS IN
HEALTH AND DISEASE
Featured Topic
Physiology Section)
Chaired: D. Kravtsov and T. Thai
Ion Transport
10:30 Ion Transport Defects and Secretory Diarrhea. N.
Ameen. Yale Univ. Sch. of Med.
11:00 An Investigational Anti-cancer Agent Synergizes with
VX-809 in F508del Correction. A. Ambrosetti, Y. Fan,
E.F. Kirby, R.M. Riggs, X.R. Wang. Samford Univ.
McWhorter Sch. of Pharm. and Univ. of Alabama at
11:15 Store Operated Ca2+ Entry Suppressed TGFβ1- Smad3
Signaling Pathway in Glomerular Mesangial Cells.
S. Chaudhari, W. Li, R. Ma. Univ. of North Texas Hlth.
Sci. Ctr. (1224.28)
11:30 The Physiological Effect of Altering Mitochondrial
Calcium Uptake in the Renal Cortical Collecting Duct.
L.I. Galarza-Paez, D.C. Eaton, L. Zou, O. Al-Khalili,
H. Ma, J.M. Sands, J.D. Klein, T.L. Thai. Emory Univ.
Sch. of Med. (1224.13)
11:45 Human CLCA2 Modulates the Conductance of Ano1 by
Regulating Intracellular Calcium Level. A. Sharma, G.
Ramena, L. Premkumar, R.C. Elble. So. Illinois Univ.
Sch. of Med. (1224.44)
12:00 Marked Dysfunction in Gating Properties and Surface
Expression of Podocyte TRPC6 Channels in
Experimental Models of Primary and Secondary
Focal and Segmental Glomerulosclerosis In Vivo and
In Vitro. S.E. Dryer, E.Y. Kim, H. Roshanravan. Univ.
of Houston. (1224.29)
12:15 Modulation of the BK Channel during Acute Spinal Cord
Injury Is Neuroprotective. M.C. Jacobsen, K.A. Lett,
M. Karnitsky, B.M. Arwini, J.M. Barden, J. Buttigieg.
Univ. of Regina, Canada. (1224.42)
476. JULIUS H. COMROE, JR. DISTINGUISHED
LECTURESHIP OF THE APS
RESPIRATION SECTION
Chaired: C. Schnackenberg and C. Richards-Williams
Career Development
10:30 Developing the Leader Within You: Head, Heart and
Gut. David Brooks. Johnson & Johnson.
10:55 Discovering the Leader Within You: Where You’ve Been.
Thomas Herzig. U.S. Navy, Groton, CT.
11:20 Translating Your Cv into An Effective Resume in the Life
Sciences. Andrew Green. Univ. of California, Berkeley.
11:45 Demonstrating Leadership and Management in
Practice: Examples of Success and Errors. Patricia
Molina. LSU Hlth. Sci. Ctr., New Orleans.
478. MECHANISMS OF NEUROMUSCULAR
JUNCTION DESTABILIZATION
AND FRAGMENTATION IN AGING
SKELETAL MUSCLE
Symposium
Physiology Section)
Chaired: M. Jackson and R. Hepple
10:30 Myofiber-Driven Mechanisms of NMJ Decline and
Impact. R. Hepple. McGill Univ. Hlth. Ctr.
11:00 Role of the Perisynaptic Schwann Cell in Neuromuscular
Junction
Maintenance
and
Reinnervation.
R. Robitaillle. Univ. of Montreal.
11:30 Muscle Innervation and Reactive Oxygen Species
Generation during Aging. M. Jackson. Univ.
of Liverpool.
12:00 Nerve Terminal Regrowth following Regeneration of
Muscle Fibers. W. Thompson. Texas A&M Univ.
479. NEW INSIGHTS INTO THE ROLE OF
AUTOPHAGY IN CARDIAC DISEASE
Symposium
Lecture
Chaired: K.M. Mellor and B. Hill
Mysteries and Maladies of Mitochondrial Dynamics.
G. Sieck. Mayo Clin. Col. of Med.
10:30
146
Novel Glycogen Autophagy Mechanisms in the Diabetic
Heart. L. Delbridge. Univ. of Melbourne.
TUESDAYPHYSIOLOGY
11:00
Insulin Regulation of Cardiac Autophagy. E.D. Abel.
Univ. of Iowa.
11:30 Mitophagy and Biogenesis in the Homeostatic
Intracellular Repair Response to Ischemia.
R. Gottlieb. Cedars Sinai Hosp.
12:00 Role of Mitochondrial Autophagy during Pathological
Hypertrophy and Heart Failure. J. Sadoshima.
Rutgers New Jersey Med. Sch.
480. SHEAR STRESS-INDUCED
MECHANOTRANSDUCTION IN ENDOTHELIAL
CELLS: IMPLICATIONS FOR VASCULAR
HEALTH AND ADAPTATIONS TO
PHYSICAL ACTIVITY
12:10
Use of Patch-Clamp Analysis to Study Sodium Transport
in Isolated Split-Open Cortical Collecting Ducts.
A. Staruschenko. Med. Col. of Wisconsin.
482. THE MIND MATTERS: PSYCHOLOGY
AS AN OVERLOOKED VARIABLE IN
AUTONOMIC PHYSIOLOGY
Featured Topic
Regulation Section)
Chaired: E. Wehrwein and J. Carter
Symposium
Hypertension
Neurophysiology
Chaired: Y. Hellsten and S. Egginton
10:30 Microvascular Response to Altered Endothelial
Phenotype in High and Low Shear Environments.
S. Egginton. Univ. of Leeds.
11:00 Response of the Arterial Vascular Tree to Shear
and Consequences for Vascular Remodeling.
M. Laughlin. Univ. of Missouri Sch. of Med.
11:30 Molecular Regulation of Shear Stress-Induced
Mechanotransduction in Man. L. Gliemann. Univ.
of Copenhagen.
12:00 Shear Stress Modulation of Crosstalk between
Endothelial Cells and Skeletal Myocytes. T. Haas.
Univ. of York, Toronto.
481. STILL UNRAVELING THE MYSTERIES OF THE
KIDNEY WITH ISOLATED TUBULES AFTER ALL
THESE YEARS
Symposium
Chaired: J.M. Sands and H.L. Brooks
10:30 History of the Development of Tubule Perfusion.
M. Burg. NHLBI, NIH.
10:55 Use of Adenovirus-Mediated Gene Transfer and
Microscopy to Study NaCl Transport and Signaling in
the Perfused Thick Ascending Limb. G. Ares. Henry
Ford Hosp.
11:20 Use of Knock-Out Mice and Electron Microscopy to
Study Chloride and Bicarbonate Transport in Perfused
Cortical Collecting Ducts. S. Wall. Emory Univ.
11:45 Use of Perfused Tubules and 3-D Digital Models of
the Renal Medulla to Study the Urine Concentrating
Mechanism. T. Pannabecker. Univ. of Arizona.
10:30 Psychophysiology: The Influence of Personality and
State of Mind in Autonomic Neural Control and
Cardiovascular Reactivity Studies. J. Moser. Michigan
State Univ.
10:45 Renal Pelvic Afferent Nerves Are Responsible for
Greater Resting and Evoked Vasoconstrictor Tone
in Individual Rats. M.M. Knuepfer, N.B. HoffmanSchepers, J.L. Perry. St. Louis Univ. Sch. of Med.
(1238.1)
11:00 Cardiovascular and Behavioral Sequelae of Witnessing
Social Defeat Stress in Male and Female Rats. C.M.
Lombard, M.N. Melson, J.R. Fadel, C.S. Wood, S.K.
Wood. Univ. of South Carolina Sch. of Med. (1238.3)
11:15 Impaired Autonomic Regulation in Posttraumatic
Stress Disorder. A.P. Swiercz, J. Park, L. Hopkins,
C. Moshfegh, J. Wiaderkiewicz, C.N. Young, P.J.
Marvar. George Washington Univ. and Emory Univ.
(1238.7)
11:30 Baroreflex Dysfunction and Augmented Sympathetic
Nerve Responses during Combat-Related and
Noncombat-Related Mental Stress in Veterans with
Post-Traumatic Stress Disorder. J. Park, P.J. Marvar,
P. Liao, M.L. Jefferson, B.O. Rothbaum. Emory
Univ., Atlanta VA Med. Ctr., Decatur and George
11:45 Oxidative Stress Contributes to Microvascular
Endothelial Dysfunction in Humans with Major
Depressive Disorder. J.L. Greaney, L. Santhanam,
E.F. Saunders, L.M. Alexander. Penn State, Johns
Hopkins Univ. Sch. of Med. and Penn State Col. of
Med. (1238.9)
12:00 Slow Breathing Reductions in Mean Arterial Pressure
Are Dependent on Psychological Characteristics.
K.L. Kelly, J. Lin, J.M. Poteracki, K.M. Adams, C.A.
Kelly, B.J. Wegner, L.P. Newhouse, J.S. Moser, E.A.
Wehrwein. Michigan State Univ. (1238.11)
12:15 Does Trait Anxiety Influence Muscle Sympathetic Nerve
Activity Responsiveness in Humans? J.R. Carter, I.T.
Fonkoue. Michigan Technol. Univ. (1238.12)
147
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PHYSIOLOGYTUESDAY
483. HISTORY OF PHYSIOLOGY LECTURE
4:45
Lecture
(Sponsored by: APS History of Physiology Group)
Hotel, Marina Ballroom DE
5:00
Rediscoveries of Oxygen. J. Severinghaus. UCSF Sch.
of Med.
484. ROBERT M. BERNE DISTINGUISHED
CARDIOVASCULAR SECTION
High Salt Intake Alters Renal Medullary Clock Genes
via ETB Receptors. J.S. Speed, K.A. Hyndman, M.
Kasztan, J.G. Johnston, K.J. Roth, M.E. Young,
J.S. Pollock, D.M. Pollock. Univ. of Alabama at
Role of Kir5.1 (Kcnj16) Channel in the Control of
Potassium Homeostasis in the Kidney. O. Palygin, V.
Levchenko, A. Geurts, A. Staruschenko. Med. Col.
487. AUGUST KROGH DISTINGUISHED
LECTURESHIP OF THE APS COMPARATIVE
AND EVOLUTIONARY PHYSIOLOGY SECTION
Lecture
Lecture
(Supported by Novo Nordisk Foundation)
Oh, the Places You’ll Go! My Many Colored Serotonin
(Apologies to Dr. Seuss). S. Watts. Michigan State Univ.
Oxidative Stress
485. TANG PRIZE IN BIOPHARMACEUTICAL
SCIENCE AWARD LECTURE
Lecture
(Sponsored by: Tang Prize Foundation)
488. GENE REGULATION IN SKELETAL MUSCLE
Tue. 3:00 pm—San Diego Convention Center, Room 33BC
Featured Topic
Chaired: N. Li
3:15
3:45
4:00
4:15
4:30
148
Symposium
Cancer Immunotherapy by PD-1 Antibody. T. Honjo.
Kyoto Univ. Grad. Sch. of Med.
486. CROSS-TALK BETWEEN SALT AND OTHER
FACTORS IN HYPERTENSION
Interaction between Dietary Fructose and Salt in
the Regulation of Blood Pressure. P. Ortiz. Henry
Ford Hosp.
Inhibition of Hypoxia Inducible Factor-1α in the Renal
Medulla Contributes to Fructose-Induced SaltSensitive Hypertension. J. Hu, Q. Zhu, P-L. Li, K.M.
Boini, N. Li. Virginia Commonwealth Univ. (1216.2)
High Salt Activates Human Monocytes and Promotes
Their Conversion into Dendritic Cells via Formation
of Immunogenic Isoketal-Adducts. A. Kirabo, N.
Barbaro, J.D. Foss, K.R. Montaniel, W. Chen, D.G.
Harrison. Vanderbilt Univ. Med. Ctr. (1216.4)
Deletion of Rag1 Prevents High Dietary Protein-Induced
Exacerbation of Hypertension and Renal Injury in Dahl
SS Rats. J.M. Abais-Battad, H. Lund, D.L. Mattson.
Med. Col. of Wisconsin. (1216.3)
Modulation of Salt and Mineralocorticoid Sensitivity of
Blood Pressure by the Circadian Clock Protein Per1.
K. Solocinski, X. Wen, K-Y. Cheng, J. Lynch, C.S.
Wingo, B.D. Cain, M.L. Gumz. Univ. of Florida and
NF/SG Veterans Hlth. Syst. (1216.10)
Physiological and Evolutionary interactions among
Body Size, Metabolic Rate and Oxygen. J. Harrison.
Arizona State Univ.
Chaired: G. Nader
3:15
Nuclear Receptors and Exercise Mimetics: Running
around Physiology. R. Evans. Univ. of Kentucky.
3:45 Muscle Gene Control Elements Exhibit Differential
Transcriptional Activities in Skeletal Muscle Fiber
Types, Cardiac Muscle, and Non-muscle Tissue
Types. S. Hauschka. Univ. of Washington.
4:15 Alternative Splicing Transitions during Postnatal
Skeletal Muscle Development Contribute to Adult
Muscle Function. T. Cooper. Baylor Coll. of Medicine.
4:45 Delineating Gene Regulatory Circuitry Controlling
Muscle Fitness. D. Kelly. Sanford-Burnham Med.
Res. Inst.
489. HORACE W. DAVENPORT DISTINGUISHED
GASTROINTESTINAL AND LIVER
PHYSIOLOGY SECTION
Lecture
The intermediate Filament Cytoskeleton: From Bench to
Bedside. B. Omary. Univ. of Michigan.
TUESDAYPHYSIOLOGY
490. HORMONES AND REPRODUCTION
Featured Topic
492. MECHANISMS REGULATING SKELETAL
MUSCLE MASS
Featured Topic
Metabolism Section)
Physiology Section)
Chaired: W. Samson
Chaired: S.C. Bodine
Neurobiology
Neurophysiology
3:15 Novel
Peptide/Receptor
Interaction
Controlling
Reproduction. L. Stein. Saint Louis Univ.
3:45 Hypothalamic Circuits Controlling Reproductive
Hormone Secretion. D. Belsham. Univ. of Toronto.
4:15 Estrogen Treatment Restores Muscle Mitochondrial
Function and Redox Homeostasis, Reversing the
Pro-diabetogenic State Induced by Ovariectomy. M.J.
Torres, L. Reese, C. Smith, E. Pennington, T. Ryan,
R. Shaikh, P.D. Neufer. East Carolina Diabetes and
Obesity Inst., East Carolina Univ. (1247.1)
4:30
Artificial Synchronization of Ovarian Hormones in Early
Pregnancy Improves Adverse Pregnancy Outcomes
Associated with Preeclampsia in the BPH/5 Mouse
Model. J.L. Sones, A.K. Woods, J. Cha, S.K. Dey,
R.L. Davisson. Cornell Univ. and Cincinnati Children’s
Res. Fndn. (1247.4)
4:45
Association between Hormonal Contraceptive Use and
Prevalence of Premenstrual Symptoms. A.C. Jarosz,
J. Jamnik, A. El-Sohemy. Univ. of Toronto. (1247.5)
5:00 Polycystic
Ovary
Syndrome
Phenotype
in
Hyperinsulinemic but Normoandrogenic Monosodium
L-Glutamate Obese Rats. R.S. Gaspar, R.O.A.
Benevides, J.L. Fontelles, C.C. Vale, L.M. França,
A.M.A. Paes. Fed. Univ. of Maranhão, Brazil. (1247.6)
491. ION, WATER, AND GAS MOVEMENTS THROUGH
THE BRAIN IN HEALTH AND DISEASE:
PUTTING IT ALL TOGETHER
Symposium
Physiology Section)
3:15
TGF and BMP Signaling in Skeletal Muscle and the
Regulation of Muscle Mass. P. Gregorevic. Baker IDI
Heart and Diabetes Inst., Melbourne, Australia.
3:45 Mechanotransduction
and
the
Regulation
of
Skeletal Muscle Mass. T. Hornberger. Univ.
4:15
Multiple Tripartite Motif E3 Ubiquitin Ligases Facilitate
Skeletal Muscle Atrophy. H. Manring, E.M. Smith,
E.X. Beck, K.E. McElhanon, L. Gushchina, W.A. He,
D.C. Guttridge, N. Weisleder. The Ohio State Univ.
(1244.9)
4:30 Postnatal Muscle Growth Is Dependent on Satellite
Cell Proliferation Which Demonstrates a Specific
Requirement for Dietary Protein. M.L. Fiorotto, D.A.
Columbus, J. Steinhoff-Wagner, A. Suryawan,
H.V. Nguyen, T.A. Davis. USDA, Baylor Col. of Med.
(1244.1)
4:45 Contribution of Satellite Cells to Skeletal Muscle
Proteostasis during Advanced Age and Aerobic
Exercise. A.R. Konopka, S.E. Ehrlicher, K.A.
Baeverstad, J. Reid, F.F. Peelor III, A.L. Confides,
E.E. Dupont-Versteegden, B.F. Miller, K.L.
Hamilton. Colorado State Univ. and Univ. of Kentucky
Col. of Hlth. Sci. (1244.2)
5:00 Leucine Modulates mTORC1 Signaling by Acting
Specifically to Alter the Phosphorylation Status of
Sestrin2. S.R. Kimball, B.S. Gordon, J.E. Moyer,
M.D. Dennis, L.S. Jefferson. Penn State Col. of Med.
and Univ. of Central Florida. (1244.3)
493. MECHANOBIOLOGY OF FIBROSIS ACROSS
ORGAN SYSTEMS
Symposium
Chaired: M.E. O’Donnell and J.J. Iliff
Tue. 3:15 pm—San Diego Convention Center, Ballroom 20A
Chaired: D. Tschumperlin
Ion Transport
3:15
3:45
4:15
4:45
Role of Blood Brain Barrier Ion Transporters and
Channels in Brain Edema Formation. M. O’Donnell.
Univ. of California.
Aquaporins as Gas Channels. W. Boron. Case Western
Reserve Univ.
The Glymphatic System. J. Iliff. Oregon Hlth. & Sci. Univ.
Role of Aquaporins in Brain injury. J. Badaut. Univ.
of Bordeaux.
3:15
3:55
4:35
Mechanobiology in Liver Fibrosis: Implications for
Fibrosis Progression and Regression. R. Wells. Univ.
of Pennsylvania.
Targeting Cytoskeletal/Mechanical Signaling Pathways
in Fibrosis. R. Neubig. Michigan State Univ.
Novel Tools to Image and Target the Extracellular Matrix.
T. Barker. Georgia Tech.
149
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PHYSIOLOGYTUESDAY
494. METABOLIC REGULATION OF CARDIAC
FUNCTION IN DIABETES: EPIGENETICS AND
POSTTRANSLATIONAL MECHANISMS
Featured Topic
4:45
Disease. B. Smith. Univ. of Florida.
Spinal Stimulation as a Rehabilitative Tool to Restore
Respiratory Motor Output after Spinal injury.
E. Gonzalez-Rothi. Univ. of Florida.
496. NOVEL MECHANISMS AT THE LEVEL OF THE
SOLITARY TRACT NUCLEUS (NTS)
Featured Topic
Chaired: A. Wende and J. Chatham
3:15
3:15
3:15
3:15
3:15
3:15
O-GlcNAcylation at the Interface of Cardiac Responses
to Exercise and Nutrient Excess. S. Marsh.
Washington State Univ.
Glucose-Mediated Regulation of UQCRFS1 and the
Cardiac Metabolome. L.J. Williams, M.K. Brahma,
M.M. McCrory, A.R. Wende. Univ. of Alabama at
Cardiomyocyte Glucose Handling Is Influenced by
β-Adrenergic and AMPK Regulation of Glycogen and
Autophagy in Metabolic Stress Settings. K.M. Mellor,
U. Varma, E. Stevens, L.M.D. Delbridge. Univ. of
Auckland and Univ. of Melbourne. (1273.8)
CaMKIId as a Nodal Mediator of Insulin Signaling
and Adrenergic Signaling in Cardiomyocytes – a
Signaling Network Map Profiling by Quantitative
Phospho-proteomics. S. Dewan, A. Campos, S. Wu,
J. Stowe, A. Wolf, D.M. Bers, L.M. Brill, J.H. Brown,
A. McCulloch. UCSD, Sanford Burnham Med. Res.
Inst., La Jolla and Univ. of California, Davis. (1273.3)
Anti-diabetic Effects of Class 1 Histone Deacetylase
Inhibition in a Rodent Model of Type 2 Diabetes
Mellitus. E. Johnson, S. Marsh. Washington State
Univ. (1273.6)
Metabolomics Meets Epigenetics: Posttranslational
Remodeling of the Chromatin Structure. J. Hanover.
NIH, NIDDK.
495. NEUROSTIMULATION TO RESTORE BREATHING
WITH NEUROMUSCULAR DISORDERS
Symposium
Chaired: G.S. Mitchell and K. Streeter
Neurobiology
Neurophysiology
3:15
3:45
4:15
150
Spinal Cord Stimulation for Restoring Mobility after
Spinal Cord injury. V. Mushahwar. Univ. of Alberta.
Diaphragm Pacing as a Rehabilitative Tool to Restore
Breathing Capacity in Individuals with SCI. E. Fox.
Univ. of Florida.
Diaphragm Pacing as a Rehabilitative Tool to Restore
Breathing Capacity in Individuals With Pompe
Chaired: S. McDougall
Neurobiology
Hypertension
Neurophysiology
3:15
Spontaneous Neurotransmission in the NTS Conveys
Circuit State. J. Peters. Washington State Univ.
3:45 Inflammation Increases the Excitatory Synaptic
Transmission in the Nucleus Tractus Solitarius of Rats
Submitted to Sustained Hypoxia. L. Lima Silveira,
D. Accorsi-Mendonca, L.G.H. Bonagamba, B.H.
Machado. Univ. of São Paulo, Ribeirão Preto.
(1232.5)
4:00
GABA Transporters within the Nucleus Tractus Solitarii
Modulate GABAergic Signaling, Neuronal Activity and
Cardiorespiratory Function. M.P. Matott, E.M. Hasser,
D.D. Kline. Univ. of Missouri-Columbia. (1232.4)
4:15
Adult Neurogenesis in the NTS: A Role in Hypertension?
Song Yao. Florey Inst., Parkville, Australia.
4:45
High Fat Diet Induced Inhibition of Sympathetic Outflow
to Brown Adipose Tissue: Role of the Nucleus Tractus
Solitarius. C.J. Madden, S.F. Morrison. Oregon Hlth.
& Sci. Univ. (1232.2)
5:00 Dysfunction of Astrocytes in the Nucleus Tractus
Solitarii Leads to Cardiorespiratory Compromise. W.T.
Talman, L-H. Lin, S. Jones, D.N. Dragon, Y. Wu, G.B.
Richerson. Univ. of Iowa and VA Med. Ctr. (1232.3)
497. APS BUSINESS MEETING
Business Meeting
Tue. 5:45 pm—San Diego Convention Center, Ballroom 20A
WEDNESDAY, APRIL 6
Plenary
Wed. 8:00 am—San Diego Convention Center, Room 6D
8:00
Awardee Introduction.
8:05 498.1
Regulation of Gene Expression by Complex
RNA Molecules. A.M. Pyle. Yale Univ., HHMI.
Plenary
8:45
Awardee Introduction.
8:50 499.1
Physical Mechanisms of Cell Organization
on Micron Length Scales. M.K. Rosen. Univ. of Texas
Southwestern Med. Ctr., HHMI.
500. REPAIR DURING DNA REPLICATION
Symposium
Wed. 9:45 am—San Diego Convention Center, Room 1B
Chaired: J.M. Berger
9:45
9:50 500.1
DNA Repair during DNA Replication. D.
Cortez. Vanderbilt Univ. Sch. of Med.
10:15
Early Replication Stress Leads to Abnormal
Mitosis and Genome Rearrangement. S. Forsburg. Univ. of
So. California. (793.4)
10:30 500.2
Molecular Mechanism of DNA Interstrand
Crosslink Repair. A. Smogorzewska, M. Kottemann, B. Conti,
S. Thongthip, K. Rickman, F. Lach. The Rockefeller Univ.
10:55
A Nucleolar Role for the Fanconi Anemia
Pathway Protein, FANCI, in rDNA Transcription. S.B. Sondalle,
S. Longerich, P. Sung, S.J. Baserga. Yale Univ. (1048.1)
11:10
Multiple Invasions-Induced Chromosomal
Rearrangements. A. Piazza, W-D. Heyer. Univ. of California,
Davis. (576.2)
11:25 500.3
Chromatin Replication and Epigenome
Maintenance. A. Groth. BRIC, Univ. of Copenhagen.
11:50
Discussion.
501. RADICALS IN CATALYSIS
Symposium
Wed. 9:45 am—San Diego Convention Center, Room 6C
Chaired: C. Krebs
10:15
Radical SAM Enzyme-Catalyzed Formation
of Thioether Crosslinks in Ribosomal-Produced Peptides:
Formation of the RiPP Natural Product Thuricin CD by the
Radical Sam Enzymes TrnC and TrnD. J.T. Jarrett, C.E.
Holjencin. Univ. of Hawaii at Manoa. (1084.2)
10:30 501.2
Capturing a Cryptic Biosynthetic Intermediate
Reveals Novel Enzyme Functions in Molybdenum Cofactor
Biosynthesis. K. Yokoyama, B.M. Hover, N.K. Tonthat, M.A.
Schumacher. Duke Univ. Med. Ctr.
10:55
Structure of a Key Intermediate in the Reaction
Catalyzed by the Dual Specificity Methylase RlmN. E.L. Schwalm,
T. Grove, A. Boal, S. Booker. Penn State and HHMI. (1085.1)
11:10
Sifting through the Haystack to Find the Needle:
Spatial Identification of a Structural Conduit for Transfer of
Thermal Activation Energy in the Course of C-H Cleavage in
Soybean Lipoxygenase. A. Offenbacher, S. Hu, A. Nguy, A.
Iavarone, J. Klinman. Univ. of California, Berkeley. (1086.1)
11:25 501.3
Structural Basis for Divergent Reaction Outcomes
in Iron(II)/2OG-Dependent Oxygenases. A. Boal. Penn State
11:50
Discussion.
W
E
D
502. PROTEIN DEGRADATION IN HEALTH
AND DISEASE
Symposium
Wed. 9:45 am—San Diego Convention Center, Room 1A
Chaired: C. Joazeiro
9:45
9:50 502.1
Dissection and Reconstitution of Autophagic
Membrane Fusion. Q. Zhong, J. Diao, R. Liu, Y. Rong. Univ. of
Texas Southwestern Med. Ctr. and Stanford Univ.
10:15
A High-Content RNAi Screen to Elucidate
Novel Effectors of Cardiac Proteotoxicity. P.M. McLendon,
G. Davis, J. Gulick, K. Shay-Winkler, J.D. Molkentin, J.
Robbins. Cincinnati Children’s Hosp. Med. Ctr. (1063.3)
10:30 502.2
Twists and Turns in Ubiquitin Conjugation
Cascades. B. Schulman. St. Jude Children’s Res. Hosp.
10:55
An Inherited Developmental Disorder Reveals
Functions for WHAMM and the Actin Nucleation Machinery in
Early Stages of Autophagy. K. Campellone, A. Mathiowetz, A.
Russo, E. Baple, A. Crosby. Univ. of Connecticut and Univ. of
Exeter Med. Sch. (1064.2)
11:10
APOBEC3F-Vif Binding Interface Elucidated
by Multiple Experimental Approaches. R. Harris, C. Richards,
N. Shaban, B. Anderson, O. Demir, R. Amaro. Univ. of
Minnesota and HHMI, Minneapolis and UCSD. (1069.1)
11:25 502.3
Ubiquitin and ISG15 Conjugation at the
Ribosome. J. Huibregtse, L. Canadeo, C. Swaim, H.
O’Connor. Univ. of Texas at Austin.
11:50
Discussion.
9:45
9:50 501.1
Enzymes Involved in Secondary Metabolism
and RNA Modification. V. Bandarian. Univ. of Utah.
151
BIOCHEMISTRYWEDNESDAY
503. BIOCHEMICALLY-INFORMED IMAGING IN
DRUG DISCOVERY
Symposium
Wed. 9:45 am—San Diego Convention Center, Room 6E
9:45
9:50 503.1
Exploiting the Biology of Trehalose to Develop
Novel Imaging Probes for Tuberculosis. C. Barry. NIAID, NIH.
10:15
Targeting
Peptide
Bound
to
Major
Histocompatibility Complex Allows Visualization of Insulin Secreting
Beta Cells In Vivo. K.R. Miller, J. Taft, A. Koide, M. Johnson, R.
Tisch, S. Koide, E. Collins. Univ. of Mount Union, Univ. of Chicago
and Univ. of North Carolina at Chapel Hill. (1098.2)
10:30 503.2
Imaging
Mass
Spectrometry
–
The
Pyrazinamide Enigma. B. Prideaux, J. Sarathy, L. Via, P.
Gopal, C. Barry, T. Dick, V. Dartois. New Jersey Med. Sch.,
Rutgers Univ., NIAID, NIH and Natl. Univ. of Singapore.
10:55
Sequestration-Mediated Downregulation of de
Novo Purine Biosynthesis by AMPK. D.L. Schmitt, S. An. Univ.
of Maryland Baltimore County. (850.9)
11:10
Effects of Synthetic Ligands on Heterodimer
Pairs Regarding PPARα, RXRα and LXRα. E.E. Delman, S.D.
Rider, H.A. Hostetler. Wright State Univ. (630.1)
11:25 503.3
Fluorogenic Probes for Detecting Mycobacterial
Hydrolases. K. Beatty, S. Levine, K. Tallman. Oregon Hlth. &
Sci. Univ.
11:50
Discussion.
504. LIPIDS AND ENERGY METABOLISM
Symposium
Wed. 9:45 am—San Diego Convention Center, Room 6F
Chaired: K.M. Reinisch
9:45
9:50 504.1
Regulation and Function of Fatty Acid
Desaturases. J. Ntambi, M.S. Burhans, C-A. Guo, L.M. Bond.
Univ. of Wisconsin-Madison.
10:15
Multifaceted Regulation of Hepatic G0/G1
Switch Gene 2 Expression and Relevance to Lipid Metabolism.
B. Heckmann, X. Zhang, A. Saarinen, J. Liu. Mayo Clin.,
Scottsdale. (1134.4)
10:30 504.2
A Potential Mediator of Diabetes-Associated
Cardiovascular Disease: The Enzyme FMO3. S. Biddinger.
Boston Children’s Hosp.
10:55
A Novel Mouse Model with Targeted and Inducible
Deletion of Intestinal CTP:Phosphocholine Cytidylyltransferase α.
J.P. Kennelly, J. van der Veen, R. Nelson, R. da Silva, K. Kelly,
K. Leonard, S. Wan, R. Jacobs. Univ. of Alberta. (1134.6)
11:10
Evidence of a Perilipin-5 Splice Variant. B.L.
Ranzau, D.M. DuBreuil, T. Hubbell, J.T. Tansey. Otterbein
Univ. (1134.7)
11:25 504.3
Discovery of a Novel Class of Naturally-Occurring
Lipids with Anti-diabetic and Anti-inflammatory Effects. B. Kahn,
M.M. Yore, I. Syed, P.M. Moraes-Vieira, T. Zhang, M.A. Herman,
E. Homan, J. Lee, S. Chen, O.D. Peroni, A. Hammarstedt, R.
Patel, T.E. McGraw, U. Smith, A. Saghatelian. Beth Israel
Deaconess Med. Ctr. and Harvard Med. Sch.
11:50
Discussion.
152
505. BEYOND THE BENCH: MAXIMIZING GRADUATE/
POSTDOCTORAL TRAINING FOR NONRESEARCH STEM CAREERS
Symposium
Wed. 12:30 pm—San Diego Convention Center, Room 6A
Chaired: S. Blatch
12:30
12:30 505.1
To Stay (at the Bench) or Go? Determinants
of Career Decision-Making in Recent PhD Graduates. K.D.
Gibbs, K. Griffin. NCI, NIH and Univ. of Maryland College Park.
12:30 505.2
Finding Your Fit among Career Options with a
PhD. R. McGee. Northwestern Univ.
12:30 505.3
Science Policy: Making a Big Difference
in the Future of Discovery. D.R. Wilson. Indian Hlth. Svc.,
Rockville, MD.
12:30
Discussion.
506. BACTERIAL GLYCOSYLATION AND
THE MICROBIOME
Symposium
Chaired: J. Kohler
2:15
2:20 506.1
Human Gut Bacteroidetes. H. Gilbert.
Newcastle Univ., U.K.
2:45
Lectin Nucleotide Phosphohydrolases May
Function as Co-receptors or Modulators of Several ChitinBased Oligosaccharide Signaling Events in Plants. M.E.
Etzler, N. Roberts, G. Kalsi. Univ. of California, Davis, AgRes.
Grasslands Res. Ctr., New Zealand and ITC Ltd., Bengaluru,
India. (847.2)
3:00 506.3
Proteins and Carbs – The Balanced Diet of a
Complex and Unusual Enzyme Family. A. Boraston, I. Noach,
E. Ficko-Blean, C. Stuart, D. Brochu, M. Gilbert. Univ. of
Victoria, Canada and Natl. Res. Council Canada, Ottawa.
3:25
Bacterial Glycosidases Acting on Red Blood
Cells. Y. Bourne, G. Ponchel, V. Roig-Zamboni, E.P. Bennett,
B. Henrissat, H. Clausen, G. Sulzenbacher. CNRS, AixMarseille Univ. and Copenhagen Ctr. for Glycomics. (843.5)
3:40
Bacterial Cell Wall Remodeling to Study the
Production of Immunoactivating Fragments. H. Liang, K.E.
DeMeester, C-W. Hou, C.L. Grimes. Univ. of Delaware.
(1095.3)
3:55 506.5
Interactions between Campylobacter jejuni and
AB5 Toxins in the Gut. C.M. Szymanski, R.T. Patry, M. Stahl,
J.C. Sacher, B.A. Vallance. Complex Carbohydrate Res. Ctr.,
Athens, GA, BC Children’s Hosp., Univ. of British Columbia
and Univ. of Alberta.
4:20
Discussion.
WEDNESDAYBIOCHEMISTRY
507. NON-CODING RNA AND GENE REGULATION
Symposium
Wed. 2:15 pm—San Diego Convention Center, Room 1B
Chaired: J.Q. Svejstrup
2:15
2:20 507.1
Genome Regulation by Long Noncoding
RNAs. H.Y. Chang. Stanford Univ. Sch. of Med.
2:45
Transfer RNA Fragments: A Novel Class of
Non-micro Short RNAs That Uses Ago1, 3 and 4 to Repress
Specific Target RNAs through 5’ Seed Sequences. A. Dutta, P.
Kumar, M. Kiran, C. Kuscu. Univ. of Virginia. (1054.5)
3:00 507.2
The Primary Target of Let-7 MicroRNA.
A. Pasquinelli. UCSD.
3:25
A Specialized Mechanism of MicroRNAMediated Translation in Quiescence. S. Vasudevan, S.I.A.
Bukhari, S.S. Truesdell, S. Lee, S. Kollu, A. Classon, M.
Boukhali, E. Jain, A. Yanagiya, R. Sadyrev, W. Haas. MGHHarvard Med. Sch. and McGill Univ. (1054.6)
3:40
NURF Localizes in Gene Bodies to Regulate
mRNA Processing. J. Landry, A. Alhazmi, M. Mack, A.
Petencin, H. Nelson, J. Hiegel, V. Koparde, N. Scarsdale, C.
Lyons, M. Dozmorov. Virginia Commonwealth Univ. (1053.1)
3:55 507.3
Enhancer Transcription
and
Enhancer
Function. C. Glass, D. Gosselin, V. Link, C.E. Romanoski, T.
Troutman, M. Lam, D. Eichenfeld. UCSD.
4:20
Discussion.
508. CHEMISTRY, BIOLOGY, AND SUSTAINABILITY
Symposium
509. MOLECULAR CROSSTALKS OF
MULTIPLE CONSORTIA
Symposium
Chaired: O. Lichtarge
2:15
2:20 509.1
Multi-omics of the Soil Microbiome. J.K.
Jansson. Pacific Northwest Natl. Lab., Richland, WA.
2:45
Syntrophic Metabolism of Vitamins and Amino
Acids in Gut Microbial Community as Revealed by In Silico
Genomic Analyses. M.S. Khoroshkin, D. Rodionov. IITP,
Russian Acad. of Sci., Moscow and Sanford Burnham Prebys
Med. Discovery Inst., San Diego. (819.5)
3:00 509.2
Metabolic Exchange in Microbial Communities.
A. Osterman. Sanford Burnham Prebys Med. Discovery Inst.,
La Jolla.
3:25
Evolutionary and Comparative Genome
Analysis of Phage NAD Metabolic Genes. L. Sorci, M.D.
Kazanov, S. Gerdes. Marche Polytech Univ., Italy, Russian
Acad. of Sci., Moscow and Argonne Natl. Lab., IL. (819.15)
3:40
Integrating
Reductive
and
Synthetic
Approaches in Biology Using Man-Made Cell-Like
Compartments. W. Aoki, S. Komura, E. Tamiya, M. Ueda.
Kyoto Univ. and Osaka Univ. (1074.1)
3:55 509.3
How Antibiotics Affect the Human Gut
Microbiome: Lessons from the Extreme. J. Xavier. Mem.
Sloan-Kettering Cancer Ctr.
4:20
Discussion.
510. TUMOR SUPPRESSORS/TUMOR DRIVERS
Wed. 2:15 pm—San Diego Convention Center, Room 6C
Symposium
Chaired: J. Jez
Wed. 2:15 pm—San Diego Convention Center, Room 6E
2:15
2:20 508.1
The Future of Biobased Chemicals. B. Shanks.
Iowa State Univ.
2:45
A Novel Thermotolerant β-Glucosidase from
Aspergillus nidulans Has Activity across a Broad pH Profile
and a Likely Bacterial Origin. R. Auta, I. Radecka, P. Hooley.
Univ. of Wolverhampton, U.K. and Kaduna State Univ., Nigeria.
(1070.1)
3:00 508.2
Engineering Microbial Fatty Acid Biosynthesis
as an Industrial Biotechnology Platform. A. Schirmer. REG
Life Sci., South San Francisco.
3:25
Optimization and Lipid Quantitation of Potential
Algal Biofuels Feedstocks. S.J. Brad, B.E. Umbach, E.D.
Gehlhausen, C.R. Sweet. U.S. Naval Acad., Annapolis. (838.5)
3:40
Comparison of Stability and Kinetic Properties
of DszB from N. asteroides A3H1 and R. erythropolis IGTS8.
A. Hutchinson-Lundy, A. Crithary, J.M. Schmitz, L. Watkins.
James Madison Univ. (1087.2)
3:55 508.3
Expanding the Boundaries of Biocatalysis.
H. Zhao. Univ. of Illinois at Urbana-Champaign.
4:20
Discussion.
Chaired: S. Malek
2:15
2:20 510.1
Reversing the Paradigm: Protein Kinase C as
a Tumor Suppressor. A. Newton. UCSD.
2:45
Ceramide Is a Key Factor That Regulates the
Crosstalk between TGF-β and Sonic Hedgehog Signaling at the
Basal Cilia to Control Cell Migration and Tumor Metastasis. S.
Gencer, N. Oleinik, M. Dany, B. Ogretmen. Med. Univ. of South
Carolina and Uskudar Univ. and Abdullah Gul Univ., Turkey. (1108.2)
3:00 510.2
DNAJB1-PKRACA – A Novel PKA Fusion
Protein That Drives Fibrolamellar Hepatocellular Carcinoma.
S. Simon. The Rockefeller Univ.
3:25
HER2+ Breast Cancer Metastasis Mediated by
E2F2 Copy Number Changes. E. Andrechek. Michigan State
Univ. (1108.3)
3:40
Exosomes Secreted by Inflammatory Cytokine
Stimulated Glioma Cells Carry a Repertoire of Proteins Which
Influence Progression of Glioblastoma Multiforme. R.A. Kore, E.C.
Abraham, R.J. Griffin. Univ. of Arkansas for Med. Sci. (1108.16)
3:55 510.3
Dysfunctional PKA Drives Diverse Disease
Phenotypes. S.S. Taylor, J. del Rio, J. Bruystens, G. Veglia,
E. Stefan, R. Ilouz, P. Zhang. UCSD, Univ. of Minnesota,
Minneapolis and Univ. of Innsbruck, Austria.
4:20
Discussion.
153
W
E
D
NUTRITION/PATHOLOGYWEDNESDAY
Nutrition
511. ASN SPONSORED SATELLITE 4TH GLOBAL
SUMMIT ON THE HEALTH EFFECTS OF YOGURT
ASN Satellite
(Organized and Sponsored by: Danone Institute
International and the American Society for Nutrition)
Wed. 8:00 am—San Diego Convention Center,
Room 33ABC
satellitesessions/.
512. NUTRITION AND PUBLIC HEALTH
POLICY: PROGRESS, OPPORTUNITIES
AND CHALLENGES
8:35 Panel: Cross-sector Solutions to Obesity in
Communities, Health Care and Evalutation.
P. Schwartz. Kaiser Permanente.
Communities, Health Care and Evalutation. N. Pronk.
HealthPartners, Inc.
8:45 Functional Roles for Public-private Partnerships to
Support Food and Nutrition Research. C. Woteki.
USDA, Washington DC.
9:00 Functional Roles for Public-private Partnerships to
Support Food and Nutrition Research. P. Stover.
Cornell Univ.
9:15 Principles for Building Public-private Partnerships.
S. Rowe. SR Strategy.
513. PROMISE OF METABOLOMICS FOR
ADVANCING NUTRITION RESEARCH
Symposium
Symposium
Wed. 8:00 am—San Diego Convention Center, Room
31ABC
Wed. 8:00 am—San Diego Convention Center,
Ballroom 20D
Chaired: S. Subramaniam
Chaired: A.L. Yaktine
Cochaired: P. Maruvada
8:00
8:15
Food and Nutrition Board Update. C. Garza. Boston Col.
FNB’s Roundtable on Obesity Solutions and Innovation
Collaboratives. W. Purcell. Jones Hawkins
Farmer, PLC.
Communities, Health Care and Evalutation. W. Dietz.
George Washington Univ.
8:00
Dynamic Diet-Induced Changes in Plasma Metabolomic
and Lipidomic Profiles and the Potential for Estimating
Macronutrient Intake. C. Burant. Univ. of Michigan.
Expanding Metabolomics to Exposome Analysis and
Comprehensive Food Assessments. T. Cajka. Univ.
of California, Davis.
The Metabotype of the Bloodtype, and Implications in
Health and Nutritional Research. S. Sumner. RTI Intl.
Integrated Omics: Insights into Human Pathologies.
S. Subramaniam. UCSD.
8:20
8:40
9:00
Pathology
514. WORKSHOP: LONG NON-CODING RNA
8:30
9:15
10:00
10:45
154
515. BIOMARKERS AND TARGETED THERAPY
Workshop
Minisymposium
Wed. 8:30 am—San Diego Convention Center, Room 2
Chaired: A. Dutta
Chaired: G. Vecchio
Cochaired: P. Iannaccone
Cochaired: D. Bell
Gene Expression
Cancer Biology
Enhancers Arising: eRNAs and lncRNAs. M. Rosenfeld.
Howard Hughes Med. Inst.
Long Noncoding RNAs in Human Diseases. H. Chang.
Howard Hughes Med. Inst.
Long Noncoding RNAs in Regulation of Cell Proliferation
and Differentiation. A. Dutta. Univ. of Virginia Hlth.
Sci. Ctr.
Clinical and Mechanistic Exploration of Long Noncoding
RNA in Prostate Cancer. R. Malik. Univ. of Michigan
Sch. of Med.
Neoplasia
8:30
Introductory Remarks.
8:35 515.1
Influence of PI3K and MAPK Pathway
Mutations on Response to Mono and Dual Treatment with
Targeted Kinase Inhibitors. R.S. McNeill, D.A. Canoutas, R.E.
Bash, R.S. Schmid, B.H. Constance, G.L. Johnson, C.R.
Miller. Univ. of North Carolina at Chapel Hill.
WEDNESDAYPATHOLOGY
8:50 515.2
EXPEL: A Novel Non-destructive Method for
Mining Soluble Tumor Biomarkers. A. Turtoi, B. Costanza, O.
Peulen, A. Bellahcène, E. De Pauw, O. Detry, P. Delvenne, V.
Castronovo. Univ. of Liege and Univ. Hosp. Liege, Belgium.
9:05 515.3
Optimization of a Series of Novel Chalcone
Derivatives for Anti-cancer Activity. T.L. Whited, C.R.T. Stang,
B.R. Adams, R.S. Khupse, R.W. Dudley, R.A. Schneider.
Univ. of Findlay, Col. of Pharm.
9:20 515.4
Single-Cell Biomarker Detection Identifies
Heterogeneity within Cancer Populations. D. Weldon, Y.
Williams, A. Patel. EMD Millipore, CA.
9:35 515.5
Targeting CSE1L in Colorectal Cancer. J.
Pimiento, K.G. Neill, E. Henderson-Jackson, S. Eschrich,
D-T. Chen, K. Husain, D. Shibata, D. Coppola, M. Malafa.
Moffitt Cancer Ctr., Tampa.
9:50 515.6
Whole
Transcriptome
Analysis
of
Osteosarcoma. S. Koks, E. Reimann, K. Maasalu, G. Koks,
D.H. Xuan, E. Prans, A. Martson. Univ. of Tartu, Estonia.
10:05 515.7
Downregulation
of
Alpha-L-Fucosidase
Expression Is Related to Dedifferentiation and Worse Prognosis
in Thyroid and Breast Cancer. G. Vecchio, A. Parascandolo,
C. Allocca, C. Ugolini, F. Basolo, S. Bonin, G. Stanta, M.D.
Castellone, M. Santoro, N. Tsuchida. Univ. of Naples Federico
II, ISO, Genova, Azienda Univ. Hosp. Pisana, State Univ. of
Trieste, IEOS, CNR, Naples and Tokyo Med. Dent. Univ.
10:20 515.8
Identification of Lipocalin 2 in Human
Hepatoblastoma. D.E. Bell, J. Tao, S. Singh, M. Chikina, S.
Ranganathan, S.P. Monga. Children’s Hosp. of Pittsburgh and
10:35 515.9
Exploring Molecular and Morphological
Relationships between Obesity and CtBP in Breast Cancer.
S.S. Park, D.I. Yi, D. Li, L. Crawford, G. Liang, M. Kabbout, R.
Hernandez, T. Yan, S. Ambs, J.S. Byun, K. Gardner. NCI and
NIMHD, NIH.
516. COPING WITH HEPATIC INJURY
Minisymposium
Chaired: S.P. Monga - Excellence in Cardiovascular
Research
Cochaired: M.L. Tomasi
Liver Pathobiology
8:30 516.1
The
Ghrelin/Leptin
Imbalance
during
Cholestasis Is Driven by Peripheral S1P2R-Dependent Bile
Acid Signaling. S. DeMorrow, J. Zigman, M. McMillin. Texas
A&M Hlth. Sci. Ctr., Central Texas Veterans Healthcare Syst.,
Temple and Univ. of Texas Southwestern Med. Ctr.
8:45 516.2
Regulation of p65-β-Catenin Complex and Its
Targets in Liver Injury and Regeneration. K. Nejak-Bowen,
P.K. Cornuet, S.P. Monga. Univ. of Pittsburgh.
9:00
516.3
Thrombospondin-1 Promotes Hepatic Injury and
Extrahepatic Complications during Acute Liver Failure in Mice. M.
McMillin, S. Andry, G. Frampton, S. Grant, G. Alpini, S. DeMorrow.
Texas A&M Univ. Hlth. Sci. Ctr., Central Texas Veterans Hlth. Care
Syst. and Baylor Scott & White Hlth., Temple, TX.
9:15 516.4
Paradoxical Role of Yes-Associated Protein
in Liver Injury and Regeneration following Acetaminophen
Overdose. S. Poudel, M.W. Manley, B. Bhushan, M.R. McGill,
H. Jaeschke, U. Apte. Univ. of Kansas Med. Ctr.
9:30 516.5
Lack of β-Catenin in Hepatocytes Impairs
Proliferation and Leads to Increased Morbidity in Response
to a Choline-Deficient Ethionine-Supplemented Diet. J.O.
Russell, H. Okabe, S. Singh, M. Poddar, S.P. Monga. Univ.
of Pittsburgh.
9:45 516.6
Hippo/YAP Signaling Induced by Endotoxin
Promotes Kupffer Cell Activation and Hepatic Inflammation in
Non-alcoholic Fatty Liver Disease. K. Song, H. Kwon, C. Han,
J. Zhang, L. Yao, N. Ungerleider, T. Wu. Tulane Univ. Sch.
of Med.
10:00 516.7
Maternal Obesity Programs Offspring’s
Predisposition to Non-alcoholic Fatty Liver Disease and
Steatohepatitis. U.D. Wankhade, S.V. Chintapalli, Y. Zhong, P.
Kang, K. Shankar. Univ. of Arkansas Med. Sci.
10:15 516.8
Role of TLR7 in Development of Alcoholic
Fatty Liver Disease: A New Target for Prevention of Alcoholic
Fatty Liver Disease. H. Matsumoto, C. Yang, K. Sugimoto.
Osaka Univ. Grad. Sch. of Med.
10:30 516.9
Biomarkers of Neutrophil-Mediated Liver Injury
in Patients with Alcoholic Liver Disease. B. Woolbright, W.
Dunn, E. Malle, H. Jaeschke. Kansas Univ. Med. Ctr. and
Med. Univ. of Graz, Austria.
10:45 516.10 Role
of
Sumoylation
in
Aldehyde
Dehydrogenase 2 Function during Alcoholic Liver Disease. C.
Cossu, K. Ramani, Y. Spissu, A. Floris, M.L. Tomasi. CedarsSinai Med. Ctr., Univ. of Sassari and Univ. of Cagliari, Italy.
11:00 516.11Withdrawn.
11:15 516.12 Regulation of Mesenchymal Phenotypes by
MicroRNA-21 during Alcohol-Induced Liver Injury. F. Meng,
H. Francis, K. McDaniel, G. Alpini. Baylor Scott & White
Healthcare, Texas A&M Hlth. Sci. Ctr. Col. of Med. and Central
Texas Veteran Healthcare Syst., Temple.
517. PATHOBIOLOGY OF INFECTIOUS DISEASES
Minisymposium
Immunopathology
8:30 517.1
Giardia muris Protection against Citrobacter
rodentium Colitis Is Associated with Inflammasome Activation
and Increased Release of Antimicrobial Peptides in the Gut. A.
Manko, J-P. Motta, J.A. Cotton, A. Oyeyemi, B.A. Vallance,
J.L. Wallace, A.G. Buret. Univ. of Calgary and Univ. of British
Columbia, Canada.
8:45 517.2
Cathelicidin Enhances the LPS-Inducing
Synthesis of Toll-Like Receptors 4 in the Colonic Epithelium.
M. Marin, R. Holani, C. Shah, Q. Haji, A. Odeón, E. Cobo.
CONICET, Buenos Aires and INTA, Balcarce, Argentina and
Cumming Med. Sch., Univ. of Calgary, Canada.
9:00 517.3
Androstenetriol Enhances Lung Macrophage
Host Defense against Bacterial Pneumonia in Mice. L. Kobzik,
Z. Yang, P. Lu, F. Mo, R. Loria. Harvard Univ., Brigham and
Women’s Hosp. and Virginia Commonwealth Univ.
9:15 517.4
Synonymous Codon Changes in Measles
(HMV) and Canine Distemper (CDV) Viral Nucleic Acid
Sequences Result in Gene-Specific Changes in Levels of Viral
Protein Expression. E.W. Uhl, M.L. Osborn, F.J. Michel, R.J.
Hogan. Univ. of Georgia.
155
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PATHOLOGY/PHARMACOLOGYWEDNESDAY
518. NEUROPATHOLOGY: MODELS AND
MECHANISMS OF DISEASE
Minisymposium
Chaired: C. Sigurdson
Cochaired: C. Kolarcik
Neurobiology
Neuropathology
10:00 518.1
Role of Post-translational Modifications In
Prion Strain Diversity. P. Aguilar-Calvo, C. Bett, H. Eraña,
J. Castilla, P. Nilsson, C. Sigurdson. UCSD, CIC bioGUNE,
Spain and Linköping Univ., Sweden.
10:15 518.2
The Biophysical Determinants of Prion
Neuroinvasion. C. Sigurdson, J. Lawrence, C. Bett, T. Kurt,
C. Wu, W. Surewicz, K.P.R. Nilsson. UCSD, Case Western
Reserve Univ. and Linköping Univ., Sweden.
10:30 518.3
Caveolin-1 Regulation of DISC1 as a Potential
Therapeutic Target for Schizophrenia. A. Kassan, J. Egawa,
Z. Zhang, Y. Lajevardi, K. Kim, Q.M. Nguyen, E.S. Posadas,
A. Sawada, D.V. Jeste, D.M. Roth, P.M. Patel, H.H. Patel, B.P.
Head. UCSD.
10:45 518.4
Role of Hippocampal Neurogenesis in Drug
Addiction. R.J. Morales Silva, M.H. Galinato, C. Mandyam.
Univ. of Puerto Rico, Ponce and The Scripps Res. Inst.
11:00 518.5
Brainstem Pathology Induces Peripheral
Changes Correlating with Hippocampal Markers of Alzheimer’s
Disease in Animal Model. P. Filipcik, M. Cente, S. Zorad, M.
Fecik, M. Novak. Inst. of Neuroimmunol., Axon Neurosci. SE
and Inst. of Exptl.l Endocrinol., Bratislava, Slovakia.
11:15 518.6
Changes in Plasma and Urine Docosahexaenoic
Acid Levels in Alzheimer’s Disease. A.N. Fonteh, K. Castor, E.
Chung, S. Applegate, M. Harrington. Huntington Med. Res.
Insts., Pasadena.
11:30 518.7
Effect of Stabilizing Alpha SynucleinMembrane Interactions on the Protein’s Aggregation and
Neurotoxicity. D. Ysselstein, V. Mishra, G. McCabe, J-C.
Rochet. Purdue Univ.
Pharmacology
519. RAY FULLER LECTURE IN THE
NEUROSCIENCES: SEX BIASED
STRESS SIGNALING
Lecture
Neuropharmacology
11:20
11:55
521. KEEP CALM AND TARGET PEPTIDES:
MODULATION OF STRESS-RELATED
BEHAVIORS BY NEUROPEPTIDE SYSTEMS
Symposium
Neurobiology
The Ray Fuller Lecture in the Neurosciences was established
to honor the achievements of Ray W. Fuller, PhD in applying an
improved understanding of the central nervous system to discover
better treatments for the mentally ill. Dr. Fuller was one of the
triad that discovered fluoxetine (Prozac), leading to an entire new
approach to the therapy of depression.
Molecular Pharmacology, and Drug Discovery
and Development)
Cochaired: S. Clark and V. Sabino
8:30Introduction.
8:35
Sex Biased Stress Signaling. R.J. Valentino. Children’s
Hosp. of Philadelphia, Univ. of Pennsylvania.
520. RAY FULLER SYMPOSIUM: SEX DIFFERENCES
IN BIOLOGY: CHALLENGES AND
OPPORTUNITIES FOR DRUG DEVELOPMENT
Symposium
Chaired: R.J. Valentino
9:30Introduction. R.J. Valentino. Children’s Hosp. of
Philadelphia, Univ. of Pennsylvania.
9:35 Estrogens Enhance Female Vulnerability to Drug
Addiction. P. Mermelstein. Univ. of Minnesota.
10:10 Social Defeat Stress in Males and Female: Role
of Kappa Opioid Receptors. B. Trainor. Univ. of
California, Davis.
10:45 Sex Differences in Ketamine’s Antidepressant-Like
Effects. M. Kabbaj. Florida State Univ.
156
Sex Differences in the Brain are Established Early and
Enduringly. M. McCarthy. Univ. of Maryland Sch. of Med.
Wrap up.
Neurobiology
9:30
9:35
Opening Remarks.
Genetic Dissection of the CRF-System in the Extended
Amygdala. A. Chen. Max Plank Inst. of Psychiat.
10:00 Role of Extended Amygdala PACAP in the Behavioral
Response to Acute and Chronic Stress. V. Sabino.
Boston Univ. Sch. of Med.
10:25 Neuropeptide Y in the Basolateral Amygdala: Role in
Stress Resilience. J. Urban. Franklin Univ. of Med.
and Sci.
10:50 Amygdaloid Corticotropin Releasing Factor as the
Key Mediator of Chronic Visceral Pain in Females
with a History of Early Life Stress. D.K. Prusator, B.
Greenwood-Van Meerveld. Univ. of Oklahoma Hlth.
Sci. Ctr. (720.7)
11:05 ProSAAS-Derived Peptides: Major Brain Neuropeptides
Implicated in the Regulation of Stress and RewardRelated Behaviors. L. Devi. Mount Sinai Univ.
WEDNESDAYPHARMACOLOGY
11:30 Development of Neuropeptide S Receptor Targeted
Compounds as Potential Therapies for AnxietyRelated Disorders. S. Clark. Univ. at Buffalo, SUNY.
11:55 Closing Remarks.
522. CANCER STEM CELLS AS
PHARMACOLOGICAL TARGETS
Symposium
Cochaired: J.S. Gutkind and T. Reya
Cancer Pharmacology
Cancer Biology
Targeting the Cancer Cell Cycle: The Development of
Palbociclib in Breast Cancer. R. Abraham. Pfizer Inc.
10:00 Drug Treatment or Cellular Stress Drives Tumor
Reprogramming, Progression and Drug Resistance.
D. Cheresh. UCSD.
10:30 Heterotrimeric G-Protein α Subunit Chaperone Ric-8A
as a Novel Target for Cancer Therapeutics. B. Patel.
Univ. of Rochester Med. Ctr.
10:45mTOR
Co-targeting
Strategies
Against
Oral
Malignancies andTheir Cancer Initiating Cells. Z.
Wang. UCSD
11:00 Lung Stem Cell Approaches to Understanding
Differentiation, Disease and Therapy. C. Kim. Harvard
Stem Cell Inst.
11:30 Stem Cell Properties Using Patient-Derived Circulating
Tumor Cells. M. Yu. Univ. of So. California
10:05
Mineralocorticoid Receptor Signaling and Cardiovascular
Stiffness in Insulin Resistance. J.D. Sowers. Univ. of
Missouri Sch. of Med.
10:30 Self-Renewal of Cardiomyocyte: Metabolic Signals as
Regulators of Protein Turnover. H. Taegtmeyer. The
Univ. of Texas Health Sciences Ctr.
10:55 Therapeutic Targeting of Autophagy in the Management
of Cardiometabolic Diseases. Y. Zhang. Xijing Hosp.,
Fourth Military Med. Univ.
11:20 Metabolic Syndrome Perivascular Adipose Tissue
Impairment of Aortic Reactivity Post Stroke, Improved
by NOX2 Inhibition. E. DeVallance, K. Branyan, K.
Lemaster, R. Skinner, S. Brooks, J. Frisbee, P.
Chantler. West Virginia Univ. (1269.5)
11:35 Mitochondrial Function of Cerebral Vasculature in Insulin
Resistant Zucker Obese Rats. I. Merdzo, I. Rutkai, T.
Tokes, V.N.L.R. Sure, P.V.G. Katakam, D.W. Busija.
Tulane Univ. Sch. of Med. (717.6)
11:50Summary.
524. INTRACELLULAR GPCR AND LIPID SIGNALING
Symposium
9:30
523. NOVEL TARGETS FOR TREATMENT OF
CARDIOMETABOLIC DISEASES
Symposium
Pharmacology, Neuropharmacology, and Translational
Cochaired: A. Marchese and A. Smrcka
Neurobiology
9:30
GPCR Promoted Akt Signaling from Early Endosomes.
A. Marchese. Loyola Univ. Chicago.
10:05 Ubiquitin Regulates GPCR-Induced p38 MAPK
Signaling from Endosomes. J. Trejo. UCSD.
10:35 Lipid Signaling from the Golgi. A. Smrcka. Univ. of
Rochester Med. Ctr.
11:05 Phosphatidylinositol 4-Phosphate: A Lipid’s Journey to
Fame. T. Balla. NICHD, NIH.
11:35 Structural and Functional Characterization of the
Metastatic RhoGEF P-Rex1 and Its Regulation by
PtdIns(3,4,5)P3: Towards Inhibitory Small Molecule
Development. J.N. Cash, E.M. Davis, J.J.G. Tesmer.
Univ. of Michigan. (1190.5)
11:48 Spatial Encoding of Cyclic AMP Signaling Specificity by
GPCR Endocytosis. N. Tsvetanova, M. von Zastrow.
UCSF. (1266.1)
Cochaired: J. Ren and S. Nair
9:30Introduction. J. Ren. Univ. of Wyoming.
9:40
Interplay of Oxidative Stress, Inflammation, and Cell
Death, in Diabetic Cardiomyopathy. P. Pacher.
NIAAA, NIH.
157
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PHARMACOLOGYWEDNESDAY
525. DRUG TRANSPORTER PROTEIN
QUANTIFICATION BY LC-MS/MS FOR IN VITRO
TO IN VIVO EXTRAPOLATION AND PREDICTION
OF INTERINDIVIDUAL VARIABILITY OF
TRANSPORTER MEDIATED DRUG DISPOSITION
Symposium
Pharmacology and Drug Metabolism )
Cochaired: B. Prasad and Y. Lai
9:30
Blood-Brain
Barrier
Pharmacoproteomics:
Reconstruction of In Vivo Brain Drug Distribution in
Mouse, Monkey and Diseased Models. T. Terasaki.
Tohoku Univ.
10:03 Quantitative Proteomics for IVIVE of Transporter
Mediated Drug Clearance. Y. Lai. BristolMyers Squibb.
10:36 No Escape from Models in Translating LCMS-Derived
Abundance Values!. A. Rostami. Univ. of Manchester.
11:09 Effect of Ontogeny and Pharmacogenomics on
Transporter Mediated Interindividual Variability in
Drug Disposition. B. Prasad. Univ. of Washington.
11:42 Chronic Paroxetine Treatment in Mice Leads to Adiposity
and Glucose Intolerance. W. Zha, J. Wang. Univ. of
Washington. (717.4)
526. NEW TWISTS ON NEUROTRANSMITTER
TRANSPORT: UNRAVELING NOVEL
THERAPEUTIC TARGETS FOR ADDICTION AND
PSYCHIATRIC DISORDERS
Symposium
Pharmacology and Behavioral Pharmacology )
3:33
Organic Cation Transporter 3: An Unsuspected Player
in the Actions of Amphetamine and a New Target for
Psychotherapeutic Drug Development. L.C. Daws.
Univ. of Texas Hlth. Sci. Ctr. at San Antonio.
4:01 Transporters
as
Clinical Targets
of
Drugs:
Amphetamines, New Psychoactive Substances and
the Monoamine Transporter Cycle. H.H. Sitte. Med.
Univ. Vienne, France.
4:29
DAT and EAAT3 Trafficking Regulation by Amphetamine:
Integration of Dopaminergic and Glutamatergic
Signaling. S.M. Underhill. NIMH, NIH.
4:57 Sick, Stressed, Depressed, and Addicted: Immune
Modulation of Cocaine Targets. N.L. Baganz.
Vanderbilt Univ.
5:25
Closing Remarks.
527. MODULATION OF BSEP AND MDR3 IN DRUGINDUCED LIVER INJURY
Symposium
(Cosponsored by: The Divisions for Drug Metabolism,
Drug Discovery and Development, and Molecular
Pharmacology )
Cochaired: K. He and D. Rodrigues
Toxicology
3:00Introduction. D. Rodrigues. Pfizer Co.
3:05 Integration of BSEP Inhibition Data in DILIsym®:
Perspectives from System. P. Watkins. The Hamner
Insts. for Hlh. Scis.
3:35 BSEP Inhibition in Drug Discovery Screening. R.
Morgan. Amgen, Inc.
4:05 Novel BSEP and MDR3 Assays Using Primary
Hepatocytes for Screening DILI Drugs and Species
Differences. K. He. Biotranex LLC.
4:35
The Role of Bile Salt Export Pump Gene Repression
in Drug-Induced Cholestatic Liver Toxicity. B. Garzel.
Univ. of Maryland Sch. of Pharmacy.
5:00 BSEP and MDR3 Inhibition by DILI Drugs and the
Implications with Systems Biology Analysis. J. Zhang.
Natl. Ctr. for Toxicol. Res.
Cochaired: L.C. Daws and H.H. Sitte
Neuropharmacology
Neurobiology
3:00Introduction.
3:05
Integrating Organic Cation Transporter 3 into Models
of Dopamine Clearance and Cocaine Addiction. P.J.
Gasser. Marquette Univ.
158
Join Us Next Year!
Experimental Biology 2017
April 22–26 Chicago, IL
www.experimentalbiology.org
WEDNESDAYPHARMACOLOGY/PHYSIOLOGY
528. THE BIOLOGY AND TRANSLATIONAL
POTENTIAL OF HYDROGEN SULFIDE:
ONE PERSON’S TRASH IS ANOTHER
PERSON’S TREASURE
529. TRANSLATING MICRORNA CANCER BIOLOGY
TO THERAPY
Symposium
Symposium
(Cosponsored by: The Divisions for Drug Discovery
and Development and Translational and Clinical
Pharmacology )
and Development)
Pharmacology, Cancer Pharmacology, and Translational
Cancer Pharmacology
Cochaired: J.L. Wallace and A. Papapetropoulos
Cancer Biology
Cochaired: A. Yu and A.G. Bader
3:00
Cancer Biology
3:35
3:00
H2S Actions and Interactions with NO in the Cardiovascular
System. A. Papapetropoulos. Univ. of Athens.
3:25
Diet, H2S and Longevity. J.R. Mitchell. Harvard Sch. of
Publ. Hlth.
3:50 Modulation of H2S as an Anti-cancer Strategy. C.
Szabo. The Univ. of Texas Med. Branch at Galveston.
4:15
H2S and Glucose Metabolism. L. Wu. Lakehead Univ.
4:40 Development of H2S-Releasing, GI-Safe Antiinflammatory Drugs. J.L. Wallace. Univ. of
Calgary, Canada.
5:05 Transdermal Detection of Low Concentrations of
Hydrogen Sulfide. L. Rios, D. Friedrichsen, C.
Mowry, G. Silaski, R. Shekarriz, N.L. Kanagy. Univ.
of New Mexico, Exhalix and Sandia Natl. Labs.,
Albuquerque. (1271.3)
5:18 Sodium Hydrosulfide Alleviates Cecal Ligation and
Puncture-Induced Sepsis and Elevates the Regional
Blood Flow in Septic Shock. A. Ahmad, C. Szabo.
Univ. of Texas Med. Branch and Shriners Hosp. for
Children. (1271.7)
4:10
4:45
5:15
MicroRNA Replacement Therapy. A.G. Bader. Mirna
Therapeutics, Inc.
Modulating MicroRNAs to Improve Cancer Therapy.
J.J. Welsh. Univ. of Texas MD Anderson Cancer Ctr.
A Combinatorial MicroRNA Therapeutics Approach to
Suppressing Cancer Growth. A. Kasinski. Purdue Univ.
Recombinant MicroRNAs as Novel Cancer Therapeutics.
A. Yu. Univ. of California Davis Sch. of Med.
miR-186 Suppresses Cell Proliferation and AnchorageIndependence in a Metastatic Prostate Cancer Cell
Line. D.Z. Jones, M.L. Schmidt, K.R. Hobbing,
G. Clark, L.R. Kidd. Univ. of Louisville. (936.6)
530. CLOSING RECEPTION
Special Event
Wed. 6:00 pm—San Diego Marriott Marquis & Marina
Hotel, South Tower Poolside
We invite ASPET members and pharmacology attendees to
join us for a closing reception.
Physiology
Featured Topic
NOBEL PRIZE AWARD LECTURE
Lecture
Chaired: T. Moreira
Wed. 4:45 pm—San Diego Convention Center,
Ballroom 20A
Neurobiology
Cancer Biology
532. BREATHING DISTURBANCES IN
NEUROLOGICAL DISORDERS
Molecules against Cancer or for Very Long-Term
Memory. R. Tsien. HHMI, UCSD.
Neurophysiology
8:00
8:30
Breathing Challenges in Rett Syndrome: Lessons
Learned from Humans and Animal Models.
J. Ramirez. Seattle Children’s Res. Inst.
Breathing Disturbances in Neurodegenerative Disorders.
M. Dutschmann. Florey Inst., Parkville, Australia.
159
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PHYSIOLOGYWEDNESDAY
9:00 Failure in Central Respiratory 5HT-Dependent
Chemoreception in a Genetic Model of Epilepsy.
L.T. Totola, A.C. Takakura, J.A. de Oliveira, N.
Garcia-Cairasco, T.S. Moreira. Univ. of São Paulo,
São Paulo and Ribeirão Preto. (1285.1)
9:15 Genome-Wide Assessment of the Pompe (Gaa-/-)
Mouse Cervical Spinal Cord Confirms Widespread
Neuropathology. S. Turner, A. Hoyt, D. Falk, B.
Byrne, D. Fuller. Univ. of Florida. (1285.2)
9:30
Characterization of Respiratory Activity in Spontaneously
Breathing Urethane-Anesthetized 6-OHDA SNLesioned Parkinson’s Disease Rat Model. I.C.
Solomon, W.F. Collins. Stony Brook Univ. (1285.3)
9:45 Cervical Spinal Contusion Alters NKCC1 and KCC2
Expression in Phrenic Motor Neurons. L.L. Allen, Y.B.
Seven, T. Baker, G.S. Mitchell. Univ. of Florida and
Univ. of Wisconsin-Madison. (1285.4)
8:45
533. CARDIAC MITOCHONDRIA: MORE THAN AN
ATP POWER PLANT
9:30
Symposium
(Sponsored by: Pan-American Societies)
9:00
9:15
535. MECHANISMS UNDERLYING HOST-MICROBIAL
INTERACTIONS IN PATHOPHYSIOLOGY
OF DISEASES
Chaired: V.R. Antunes and M.C. Villa-Abrille
8:00
8:30
9:00
9:30
Featured Topic
Physiology Section)
Chaired: Z. Schlader and D. Gagnon
8:00
8:30
Symposium
Mitochondria: Getting to the Heart of the Matter.
R. Gottlieb. Cedars-Sinai Heart Inst.
Targeting Mitochondrial Aldehyde Dehydrogenase 2
in Cardiac Diseases. J. Baptista Ferreira. Univ. of
São Paulo.
Mitochondrial Energetic-Redox Regulation of Heart
Disease: An Experimental-Computational Modeling
Approach. M. Aon. NIH, NIA.
Mitochondria and Cardiac Hypertrophy: Pros and Cons.
I. Ennis. Natl. Univ. de la Plata, Buenos Aires.
534. HOT, COLD, AND OLD: AGING AND THE
PHYSIOLOGY OF THERMAL STRESS
Understanding the Effects of Aging on the Body’s
Physiological Capacity to Dissipate Heat. G. Kenny.
Univ. of Ottawa.
Blunted Increases in Skin Sympathetic Nerve Activity
Contribute to the Attenuated Reflex Vasodilation in
Aged Human Skin. A.E. Stanhewicz, J.L. Greaney,
L.M. Alexander, W.L. Kenney. Penn State. (1290.1)
Evidence of Disrupted Human Heat Balance in Heart
Failure Patients Exercising in the Heat. B. Balmain,
O. Jay, S. Sabapathy, D. Royston, G. Stewart, R.
Jayasinghe, Y. Eqbal, N. Morris. Griffith Univ., Univ.
of Sydney and Gold Coast Univ. Hosp., Australia.
(1290.4)
Whole-Body Heat Loss Is Enhanced in Older Adults
following a Summer in a Humid Continental Climate.
M.P. Poirier, S. Dervis, A.D. Flouris, G.P. Kenny.
Univ. of Ottawa, Canada and Univ. of Thessaly,
Greece. (1290.13)
Brown Adipose Tissue Characteristics of Epicardial Fat
and Its Relationship with Growth during Aging in Early
Life. H. Budge, S. Ojha, P.H. Fainberg, V. Wilson,
M. Castellanos, G. Pelella, A. Lotto, H. Sacks, M.
Symonds. Univ. of Nottingham, Nottingham and
Loughborough, Glenfield Hosp., Leicester, U.K. and
UCLA. (1290.12)
Aging Modifies Reflex Cardiovascular Responses
to Local and Systemic Cold Exposure. M. Muller.
Pennsylvania State Univ. Coll. of Medicine.
Physiology Section)
Chaired: P.K. Dudeja and J. Sun
Neurophysiology
Diet, Nutrition and Metabolism, and Development
Microbiome
8:00
The Microbiome Co-Opts Genetic Pathways Linked to
Inflammatory Bowel Disease. H. Chu. Caltech.
8:30
The Impact of Diet-induced Gut Microbiota on Circadian
Rhythm and Obesity. V. Leone. Univ. of Chicago.
9:00
Bacterial-Infected Organoid Culture System for Host–
Bacterial interactions. V. Young. Univ. of Michigan.
9:30 Immunologic Tolerance to Intestinal Microbiota
Depends on Rab11 Endosome Mediated Control of
Pathogen Pattern Recognition Receptor Processing
and Signaling. N. Gao. Rutgers Univ.
536. MICROTUBULES IN LUNG DISEASE
AND RECOVERY
Symposium
Chaired: A. Birukova and T. Stevens
8:00 Microutubule
Dynamics
Modulates
Endothelial
inflammation induced by High Pulsatility Flow.
K. Stenmark. Univ. of Colorado, Denver.
160
WEDNESDAYPHYSIOLOGY
8:25
8:50
9:15
9:40
MT-Associated Trafficking of VEGFR2 Is Necessary for
Lung Recovery. Y. Komarova. Univ. of Illinois Col.
of Med.
Role of Microtubules in Chronic EC Barrier Dysfunction
in P. aeruginosa-Infected Pulmonary Endothelium.
T. Stevens. Univ. of South Alabama.
Microtubule-Dependent Mechanisms of Lung Vascular
Barrier Restoration. Y. Ke. Univ. of Chicago.
Reduced Microtubule Acetylation in Cystic Fibrosis
Epithelial Cells. S. Rymut. Case Western
Reserve Univ.
537. NEW APPROACHES FOR INDUCTION
OF ARTERIOGENESIS
Featured Topic
9:25
539. RENAL POTASSIUM SENSING MECHANISMS: A
NEW PARADIGM FOR POTASSIUM SECRETION
Symposium
Chaired: D. Ellison and A. Subramanya
8:00
8:30
9:00
Chaired: P. Rocic
9:30
8:00 Use of Ephrin-B2-Activated Peripheral Blood
Mononuclear Cells for Cellular Therapy in Patients
with Critical Limb Ischemia. B. Levy. INSERM, Paris.
8:45
Passive Heat Therapy as a Novel Approach for Inducing
Angiogenesis in Humans: Roles of Nitric Oxide.
V.E. Brunt, K.W. Needham, L.N. Comrada, M.A.
Francisco, C.T. Minson. Univ. of Oregon. (1211.1)
9:00 DPPI Deficiency Enhances Both Angiogenesis and
Arteriogenesis and Improves Cardiac Function
after Myocardial Infarction. M.A. Kolpakov, B.
Hooshdaran, X. Guo, T. Wang, K. Rafiq, L. Vlasenko,
Z. Qi, V.N.S. Garikipati, R. Kishore, S.R. Houser,
A. Sabri. Temple Univ. and Thomas Jefferson Univ.
(1211.2)
9:15 Angiotensin-(1-7) Requires both Mas1 and AT1
Receptors to Restore Angiogenesis. T. Stodola, E.
Exner, B. Hoffmann, D. Didier, A. Greene. Med. Col.
9:30
Matricryptin p1158/59 Modulates Vascular Remodeling
during Carotid Artery Bypass. P.R. Shaver, G.A. Grilo,
K.C. Barefoot, A.W. Holt, D.A. Tulis, R.M. Lust, L.E.
de Castro Brás. East Carolina Univ. (1211.4)
538. NOVEL MOLECULAR TARGETS AND
THERAPEUTIC APPROACHES IN MYOCARDIAL
INFARCTION AND HEART FAILURE
Renal Potassium Sensing. A. Terker. Oregon Hlth. &
Sci. Univ.
Regulation of Kir.4.1 in the Kidney. W-H. Wang. New
York Med. Col.
FHHt Proteins form an Endocytic Switch for the the ROMK
Channel. P. Welling. Univ. of Maryland Baltinore.
Regulation of WNK/SPAKI by Dietary K Intake.
C-L.Huang. Univ. of Texas Southwestern Med. Ctr.
540. REPROGRAMMED CELLS AS MODELS
FOR DISEASE
Symposium
W
E
D
Chaired: W.M. Chilian and E. Pashos
Microbiome
8:00
Creation of Reprogrammed Cells to Study Vascular
Growth. L. Yin. Northesast Ohio Med. Univ.
8:25 Modeling Biliary Disease Using Stem Cell-Derived
Cholangiocytes. R. Huebert. Mayo Clin.
8:50 Interrogating Cardiometabolic Association Signals
in Human iSPC-Hepatocytes. E. Pashos. Univ. of
Pennsylvania Perelman Sch. of Med.
9:15 The Use of iPS Cells to Study Type 1 Diabetes.
I. Yasuhiro. Mayo Clin.
9:40
Panel Discussion with Questions from the Audience.
541. ROLE OF OXYTOCIN IN THE CONTROL OF
ENERGY HOMEOSTASIS
Symposium
Symposium
(Sponsored by: APS Translational Physiology
Interest Group)
Metabolism Section)
Chaired: W.J. Koch and T.E. Sharp
8:00 RhoA Signaling Pathways in Heart Failure.
M. Kontaridis. Beth Israel Deaconess.
8:20
Harnessing Cardiac Progenitor Cells in Heart Disease.
J. van Berlo. Univ. of Minnesota.
8:40
Targeting Mitochondrial Calcium Exchange Mechanisms
in Heart Failure. J. Elrod. Temple Univ. Sch. of Med.
9:00 Autophagy in the Development of Heart Failure.
Å. Gustafsson. UCSD.
Translating Hydrogen Sulfide Therapeutics to the Clinic.
D. Lefer. LSU Hlth. Sci. Ctr., New Orleans.
Chaired: J. Blevins and W. Samson
8:00
increased Oxytocin Signaling Attenuates Weight Gain
in Diet-Induced Obese Rodents and Nonhuman
Primates. J. Blevins. Univ. of Washington, VA Puget
Sound Hlth. Care Syst.
161
PHYSIOLOGYWEDNESDAY
8:30
9:00
9:30
Hindbrain Oxytocin Receptor Signaling: Effects on
Energy Balance Control. Z. Yi. Univ. of Pennsylvania.
Salt-Loading Reveals Brain Oxytocin Circuits that
Modulate Stress Responding. E. Krause. Univ.
of Florida.
Effects of Oxytocin on Caloric Intake and Metabolism in
Men. E. Lawson. Harvard Med. Sch.
543. COMPARATIVE PHYSIOLOGY OF SKELETAL
MUSCLE – NOVEL STUDIES IN PLASTICITY
AND STRUCTURE
Symposium
Physiology Section)
542. ACTIONS AND INTERACTIONS OF
BAROREFLEXES, CHEMOREFLEXES
AND METABOREFLEXES IN AUTONOMIC
REGULATION AND HEART DISEASE
Chaired: B. Rourke and A. Horner
Featured Topic
Regulation Section)
10:30
11:00
Chaired: M. Amann and P. Fadel
Neurobiology
11:30
Neurophysiology
10:30
Carotid Body Chemoreflex in Animals: Health and Heart
Failure. N. Marcus. Univ. of Nebraska Med. Ctr.
11:00 Baroreflex-Metaboreflex Interaction in Animals: Health
and Heart Failure. D. O’Leary. Wayne State Univ.
11:30 Activation of the Chemo- and Cardiopulmonary Reflexes
Blunt Baroreflex Sensitivity through Independent
Mechanisms. H.G. Petersen-Jones, W.W. Holbein,
B.D. Johnson, V.A. Convertino, T.B. Curry, M.J.
Joyner. Mayo Clin., Univ. at Buffalo and U.S. Army
Inst. of Surg. Res., Houston. (1286.1)
11:45 Diastolic Dysfunction and Arrhythmia Incidence Are
Exacerbated by Central Chemoreflex Activation
in HfpEF. R. Del Rio, C. Toledo, D.C. Andrade,
C. Lucero, V. Aliaga, N.J. Marcus, C. Madrid.
Autonomous Univ. of Chile, Santiago and Des Moines
Univ. (1286.2)
12:00 Increased Brain-Derived Neurotrophic Factor in Lumbar
Dorsal Root Ganglia Contributes to the Enhanced
Skeletal Muscle Afferent Neuronal Excitability via
a MAPK-Dependent Pathway in Heart Failure. H.
Wang, G. Rozanski, I.H. Zucker. Univ. of Nebraska
Med. Ctr. (1286.3)
12:15 Unilateral Carotid Body Resection in Patients with
Resistant Hypertension: A Safety and Feasibility
Trial. E.C. Hart, L.E.K. Ratcliffe, K. Narkiewicz,
L.J.B. Briant, M. Chrostowska, J. Wolf, Szyndler,
D. Hering, A.E. Burchell, A.P. Abdala, C. Durant,
M. Lobo, P.A. Sobotka, N. Patel, J. Leiter, Z.J.B.
Engelman, A.K. Nightingale, J.F.R. Paton. Univ. of
Bristol, Gdansk Med. Univ., BARTS and London Sch.
of Med., The Ohio State Univ., Dartmouth Geisel Sch.
of Med. and Cibiem, Los Altos. (1286.4)
162
12:00
Structural Basis of Muscle Work Capacity. N. Holt. Univ.
of California, Irvine.
The Function of Oblique Striation Explained? Tuning
the Length-Force Relationship in the Muscles of
Soft-Bodied Invertebrates. J. Thompson. Franklin &
Marshall Col.
Polar Bear Skeletal Muscle Primarily Reflects Recent
Activity Rather than a Seasonal Pattern. J. Whiteman.
Univ. of Wyoming.
Why Are Sloths So Strong? Unique Muscle Modifications
for
Suspensorial
Locomotion.
M. Butcher.
Youngstown State Univ.
544. COMPARTMENTALIZATION OF SIGNAL
TRANSDUCTION IN EPITHELIAL
CELL BIOLOGY
Symposium
Chaired: R.A. Fenton and T. Rieg
Ion Transport
10:30 Compartmentalization of Cellular Signaling Using
Fluorescent
Biosensors.
J.
Zhang.
Johns
Hopkins Univ.
11:00 Monitoring Spatiotemporal cAMP Production in Living
organisms. M. Lohse. Univ. of Wuerzburg.
11:30 PDEs in cAMP Signaling. W. Richter. Univ. of
South Alabama.
12:00 Localization of β(2)-Adrenergic Receptor Mediated
cAMP Signaling Using Scanning Ion Conductance
Microscopy. J. Gorelik. Imperial Col. London.
WEDNESDAYPHYSIOLOGY
545. EMERGING NEW MECHANISM IN ALCOHOLIC
LIVER DISEASE
547. NOW HIRING PHDS: POSTDOC NOT REQUIRED
Symposium
Symposium
(Sponsored by: APS Trainee Advisory Committee)
(Sponsored by: American Federation for
Medical Research)
Chaired: A.M. Hernandez-Carretero and B. Dougherty
Career Development
Chaired: S. Liangpunsakul
10:30 Fat-Specific Protein 27/CIDEC Plays an Important
Role in Promoting Alcoholic Liver Injury in Mice and
Humans. B. Gao. NIAAA, NIH.
11:00 Role of Hepatic Microphages in Alcohol Liver Disease. C.
Ju. Skaggs Sch. of Pharm. and Pharmaceut. Sci., UCSD.
11:30 Circadian Clock Mediated Homocysteine Metabolism in
Alcoholic Fatty Liver. L. Wang. Univ. of Connecticut.
12:00 The Pivotal Role Played by Lipocalin-2 in Mediating
Detrimental Effects of Ethanol in the Liver. M. You.
Northeast Ohio Med. Univ.
546. ENDOTHELIAL DYSFUNCTION IN DIABETES
Featured Topic
Chaired: B. Dokken and C. Meininger
10:30 Effects of Glucose on the Endothelial Extracellular
Matrix. B. Dokken. Univ. of Arizona.
11:00 Hyperglycemia-Induced Glycosylation: A Driving
Force for Vascular Dysfunction in Diabetes?
B.R. Hoffmann, M.E. Widlansky, A.S. Greene. Med.
Col. of Wisconsin. (1282.13)
11:15 Dynamic Regulation of Endothelial Cell-Specific
Molecule 1 in Diabetic Mouse Kidney. X. Zheng, F.
Soroush, E. Hall, P. Adishesha, S. Bhattacharya, M.
Kiani, V. Bhalla. Stanford Univ., Temple Univ. Col. of
Engin. and UCSF Sch. of Med. (1282.12)
11:30 Thyroid Hormone Induces Vascular Relaxation through
VASP Phosphorylation at Serine239: A Potential
Therapeutic Approach to Treat Diabetic Vascular
Dysfunction. S. Samuel, A.M. Gerdes, M.A. CarrilloSepulveda. NYIT and NYIT Col. of Osteo. Med.
(1282.11)
11:45 HuR-Mediated HK2 Downregulation Leads to Coronary
Endothelial Dysfunction in Diabetic Mice. W. Wang,
A.H. Truong, A. Makino. Univ. of Arizona. (1282.2)
12:00 Enhanced Mobilization of Endothelial Ca2+ by SKA-31
Contributes to the Restoration of Agonist-Mediated
Vasorelaxation in Resistance Arteries from Type 2
Diabetic Rats. B.D. Kyle, R.C. Mishra, A.P. Braun.
Cumming Sch. of Med., Univ. of Calgary, Canada.
(1282.1)
12:15
Perivascular
Adipose
Tissue-Derived
TNFα
Neutralization Recovers Aortic Function in Metabolic
Syndrome. E. DeVallance, K. Branyan, K. Lemaster,
S. Brooks, S. Asano, R. Skinner, J.C. Frisbee, P.D.
Chantler. West Virginia Univ. (1282.7)
10:30
A Goal without a Plan Is Just a Wish. P. Clifford. Univ.
of Illinois at Chicago.
10:45 After Your PhD: The Non-traditional Career Path for
Scientists. M. Urso. Smith & Nephew Biotherapeutics,
Hull, MA.
11:00 How to Love What You Do and Be Good at It: Being
Competitive in the 21St Century Job Market. S. Zarate.
Univ. of San Diego.
11:15 Medical and Science Writing: No Postdoc Required.
A. Gwosdow. Gwosdow Assoc. Sci. Consultants,
Arlington, MA.
11:30 Successfully Attaining a Position in Academic
Technology Transfer without a Postdoc. J. Mitzelfelt.
Univ. of Maryland College Park.
11:45 From Inside the Lab to Inside the Beltway: A Career in
Science Policy. C. Wolinetz. OSP, NIH.
12:00 Transferable Skills between Academics and Industry:
Making the Most of Your PhD. B. Kirby. Nike Sport
Res. Lab.
548. RECENT ADVANCES IN THE STRUCTURE AND
FUNCTION OF EPITHELIAL TIGHT JUNCTIONS
Symposium
Physiology Section)
Chaired: R.K. Rao and S. Vetrano
10:30 Paracellular Transport as an Energy Conservation
Strategy in Renal Tubule. A. Yu. Kansas Univ.
Med. Ctr.
11:00 Tight Junction Regulation during Enteric Infection:
Benefits of Increased Permeability. J. Turner. Univ.
of Chicago.
11:30 Claudins and TAMPS in the Ischemic Blood-Brain Barrier.
I. Blasig. Leibniz Inst. of Molec. Pharmacol., Berlin.
12:00 Occludin Regulatory Motif Confers Dynamics and
Regulation of Epithelial Tight Junctions. R. Rao. Univ.
of Tennessee Hlth. Sci. Ctr.
163
W
E
D
PHYSIOLOGYWEDNESDAY
549. RECOVERY FROM EXERCISE AND
TRANSLATING POST-EXERCISE HYPOTENSION
11:45
Featured Topic
Physiology Section)
12:00
Chaired: T. Baynard
10:30
11:00
11:15
11:30
11:45
12:00
Clinical Insights into Recovery from Exercise and the
Relevance of Post-exercise Hypotension. C. Forjaz.
Univ. of São Paulo.
Influence of Time of Day on Post-exercise Hypotension
Might Be Different in Hypertensives Receiving
Different Anti-hypertensive Drugs: An Exploratory
Study. L. Brito, T. Peçanha, R. Fecchio, P. Sousa, R.
Rezende, M. Navarro, G. Silva, A. Abreu, D. MionJunior, C. Forjaz. Univ. of São Paulo. (1291.1)
Exaggerated Systolic Blood Pressure Response after
Unaccustomed High-Intensity Interval Exercise Is
Independently Related to Decreased Small Arterial
Elasticity in Normotensive African American Women.
S.J. Carter, T.U. Goldsby, G. Fisher, E.P. Plaisance,
B.A. Gower, S.P. Glasser, G.R. Hunter. Univ. of
Alabama at Birmingham. (1291.2)
Effect of Combination Ice and Compression Socks on
Resting Calf Blood Flow in Trained Male Athletes.
M.J. Hudock, J.L. Keller, A.R. Crecelius. Univ. of
Dayton. (1291.3)
The Effects of Cold Water Immersion on Inflammation,
Growth and Neurotrophic Factors in Skeletal Muscle
after Resistance Exercise. J. Peake, L. Roberts,
T. Raastad, V. Figueiredo, D. Cameron-Smith,
J. Coombes, J. Markworth. Queensland Univ. of
Technol., Univ. of Queensland, Norwegian Sch. of
Sports Sci., Oslo and Univ. of Auckland. (1291.4)
Mechanistic Insights into Recovery from Exercise and
the Cause of Post-Exercise Hypotension. J. Halliwill.
Univ. of Oregon.
12:15
551. NATURAL PRODUCTS: BIOLOGICAL
EFFECTS AND THERAPEUTIC POTENTIAL IN
HUMAN DISEASE
Symposium
(Sponsored by: American Federation for
Medical Research)
Chaired: S.S. Prabhakar and D. Wu
2:30
Green Tea and Bone Health: From Bench to Clinical
Trial. C-L. Shen. Texas Tech Univ. Hlth. Sci. Ctr.
3:00 Effects of Curcumin in Experimental Diabetic
Nephropathy. S. Prabhakar. Texas Tech Univ. Hlth.
Sci. Ctr.
3:30
Green Tea EGCG, T Cell Function, and T Cell-Mediated
Autoimmune Diseases. D. Wu. Friedman Sch. of Nutr.
Sci. and Policy, Tufts Univ.
4:00 Natural Products and Their Applications to Treat
Aging and Neurodegenerative Diseases. H. Reddy.
Garrison Inst. of Aging, Texas Tech Univ.
552. ORPHEUS — DEVELOPING BEST PRACTICES
FOR GRADUATE EDUCATION IN EUROPE
Special Session
550. REDUNDANCY AND PLASTICITY IN
RESPIRATORY CONTROL
(Sponsored by: NDOGS)
Featured Topic
Wed. 2:30 pm—San Diego Convention Center, Room 25C
Chaired: J. Barnett
Chaired: R. Bavis and N. Nichols
10:30 Oxygen Sensing by Extra-Carotid Chemoreceptors.
C. Nurse. McMaster Univ., Canada.
11:00 Role of Central and Peripheral Chemoreceptor
Interdependence in the Control of Breathing. G. Blain.
Univ. of Nice, Sophia Antipolis, France.
11:30 Loss of the Persistent Sodium Current Elicits
Homeostatic Plasticity in Respiratory Rhythm
Generation. N.A. Baertsch, S.C. Ramirez, J.M.
Ramirez. Seattle Children’s Res. Inst. (1299.10)
164
Ventilatory and Neurochemical Effects of Microdialysis
of the Ionotropic GABAA Receptor Agonist Muscimol
Into the Ventral Respiratory Column of Awake
Goats. T.M. Langer, S. Neumueller, N. Burgraff, E.
Crumley, L. Pan, M.R. Hodges, H.V. Forster. Med.
Col. of Wisconsin and Marquette Univ. (1299.8)
Ampakines Increase Spinal Respiratory Motor Output
after Cervical Spinal Cord Injury in Rats. K. Streeter,
E. Gonzalez-Rothi, M. Sandhu, D. Baekey, J.
Greer, D. Fuller. Univ. of Florida and Univ. of Alberta.
(1299.4)
Effects of A2A and 5-HT2A Antagonists on Hypoxic and
Hypercapnic Ventilatory Response in Rats Exposed
to Chronic Sustained Hypoxia. E.A. Moya, F.L.
Powell. UCSD. (1299.6)
2:30
R. Harris. Karolinska Univ.

Experimental Biology 2016 Program

Transcription

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