appendix a - Mount Sinai Hospital

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Table of Contents
INTRODUCTION & OVERVIEW 2005-2006
HONOURS/AWARDS/APPOINTMENTS
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Appointments
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Awards
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CLINICAL SERVICES
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Patient Services
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Clinical Biochemistry
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Hematopathology & Blood Transfusion
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Rapid Response Laboratory
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Pathology
10
Laboratory Genetics
11
Andrology
12
LABORATORY INFORMATICS
13
Laboratory Information System
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Expanded Interfaces
13
Citrix Support
13
Web Site/Communications
13
Paradigm Document Control System
14
Digital Imaging
RENOVATIONS & RELOCATIONS
QUALITY PROGRAMS
Accreditations, Regulatory Certifications/Registrations
External Quality Assessment Programs
Continuous Quality Improvement Activities: Indicators
Quality Management Team Activities: 2005-2006
EDUCATION
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Educational Activities July 2005 – June 2006
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Education Committee
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Medical Education
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Research Student Programs
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Technical Education
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SPONSORED RESEARCH AND INNOVATION
PRESENTATIONS & ABSTRACTS July 1, 2005 – June 30, 2006
SCIENTIFIC PAPERS July 1, 2005 – June 30, 2006
BOOKS & BOOK CHAPTERS
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APPENDIX A - Medical and Scientific Staff as at June 30, 2006
APPENDIX B - Technical & Support Staff as at June 30, 2005
APPENDIX C - Technical & Support Staff Changes
APPENDIX D - Residents
APPENDIX E - Fellows
APPENDIX F - Graduate Students 2005-2006
APPENDIX G - Post Doctoral Students
APPENDIX H - Summer Students May – August 2005
APPENDIX I - Reportable Tests
APPENDIX J - External Service Linkages
APPENDIX K - April 2006 Departmental Rounds
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INTRODUCTION & OVERVIEW 2005-2006
Over the past year, there have been two major changes
related to Pathology and Laboratory Medicine, the
establishment of Laboratory Medicine and Infection Control
as a Mount Sinai Hospital Centre of Excellence, and the
establishment of MOUNT SINAI SERVICES, the commercial
vehicle for Pathology and Laboratory Medicine and Medical
Microbiology.
Mount Sinai Hospital is in the midst of substantial
expansion and transformational change. The Toronto
Centre for Phenogenomics and the Samuel Lunenfeld
Research Institute expansion at 11 Orde Street are under
construction and will soon be operational. Mount Sinai
has also received permission and funding from the Ontario
government towards building a patient care obstetrics
facility, an ambulatory surgery centre and refurbishing
its facilities. As well, the hospital has established a new
strategic plan. This new strategic plan includes five clinical
centres of excellence: Women’s and Infant’s Health,
Chronic diseases (medicine), Surgical specialties and
Oncology, the Samuel Lunenfeld Research Institute, and
most notably, Laboratory Medicine and Infection Control.
The establishment of Laboratory Medicine and Infection
Control as a Centre of Excellence acknowledges the
strengths and stature of both Pathology and Laboratory
Medicine and Medical Microbiology not only at Mount Sinai
Hospital but in the external community. That Laboratory
Medicine and Infection Control is considered a Centre
of Excellence is a major opportunity for the laboratories
at Mount Sinai Hospital, as this is a virtually unique
organizational structure in Canadian health care.
For many years, Pathology & Laboratory Medicine has
served clients beyond Mount Sinai. These clients include
other hospitals but also pharma and medical device
corporations in the private sector. This commercial activity
has brought many benefits including connectivity to the
community and access to advanced technology from
around the world to Mount Sinai Hospital. In recognition
of these benefits, a new company, MOUNT SINAI SERVICES,
has been established to expand future commercial
opportunities related to diagnostics.
This year, a substantial boost to laboratory services
infrastructure at Mount Sinai Hospital was the award
of $1,248,000 of federal/provincial Designated Medical
Equipment funding to laboratory services. For Pathology
and Laboratory Medicine this has facilitated several
important initiatives including an automated blood bank
system, renewal of our coagulation system, and flow
cytometer, and the establishment of more automated
histologic processing technology.
Over the past year, our collaborative activity with the
Hospital for Sick Children has increased greatly. These
collaborations include perinatal pathology, and genetics.
A notable clinical development has been the establishment
of the Fred Litwin Clinical Genetics Centre which will
amplify Mount Sinai’s strength in clinical genetics. This is
accompanied by further outreach of our laboratory genetics
services including a collaborative program with Lakeridge
Health Centre.
We welcome Dr. Patrick Shannon to our staff. Dr.
Shannon is a neuropathologist with a special interest in
developmental perinatology. Dr. Shannon will join Dr.
Sarah Keating and Dr. Sandra Viero in building the regional
program in Fetal and Perinatal Pathology.
All of us were deeply saddened by the death of our
beloved colleague, Dr. Yvan Bédard. Yvan was widely
regarded as one of Canada’s most outstanding diagnostic
cytopathologists and pathology educators. In his career
at Mount Sinai Hospital spanning 34 years, Dr. Bédard
educated over 60 residents and fellows in cytopathology.
The advancement of Pathology and Laboratory Medicine
at Mount Sinai Hospital is highly dependent on expertise
of both our medical/scientific and support staff and their
capacity to work together towards the common goals
of enhancing health care, education and research. We
acknowledge their continuing contributions with gratitude
and pride. Once again, we thank the administration of
Mount Sinai Hospital led by Joseph Mapa for continuing
support and encouragement of all our endeavours.
HONOURS/AWARDS/APPOINTMENTS
Appointments
Dr. Yvan Bédard, Head of Cytopathology and Electron Microscopy, Pathology and Laboratory Medicine, has been
selected as the 2006 recipient of the Laboratory Medicine and Pathobiology, University of Toronto, Distinguished
Service Award. This award honours Dr. Bédard’s 34 years of leadership in teaching and innovative service related
to Cytopathology and Electron Microscopy, as well as his local and national contributions in the advancement of
resident education.
Dr. Terry Colgan has been appointed Section Editor for Cytopathology, Archives of Pathology & Laboratory
Medicine.
Dr. Terry Colgan has been appointed Co-Chair, Toronto Regional Co-coordinating
Committee, (for Laboratory Reform), Ministry of Health and Long Term Care,
Province of Ontario. As well, Dr. Colgan has been appointed Academic Representative
to the Laboratory Medicine Funding Implementation Committee (LMFIC) of the Ministry
of Health and Long Term Care, Ontario, and the Ontario Medical Association.
Dr. Terry Colgan has been appointed External reviewer, Division of Anatomical
Pathology, Ottawa University.
Dr. Eleftherios Diamandis has extended his clinical biochemistry administration responsibilities with his appointment
as Biochemist-in-Chief at the University Health Network.
Dr. Eleftherios was appointed as Associate Member, Samuel Lunenfeld Research Institute.
Dr. Eleftherios Diamandis has been appointed to the Editorial Board of Clinical Proteomics.
Dr. Marc Grynpas has been appointed as a scientific officer to the Canadian Institute of Health Research, Clinical
Investigation Grant Panel.
Dr. Marc Grynpas has been appointed a member of the Editorial Board, Calcified Tissue International.
Mr. Gaman Modi has been appointed as a member of the Board of Directors to the Ontario Safety Association for
Community & Healthcare for a 3 year term from 2005 to 2008. As well, Mr. Modi has been appointed as Vice
Chair to the Advisory Board of the Ontario Laboratory Accreditation Program, QMP-LS, 2005-2006 and has been
re-appointed to the Scientific Advisory Panel for the Canadian Journal of Medical Laboratory Science, 2005-2006.
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Awards
Dr. Anita Bane received the Irish-North American Association of Pathologists’ award, for her platform presentation
”BRCA2 associated breast cancers exhibit a luminal phenotype despite their high histologic grade” at the United
States and Canadian Academy of Pathology Meeting, Atlanta, 2006.
Dr. Eleftherios Diamandis was awarded the Frey-Werle commemorative gold medal from the Frey-Werle Foundation,
Australia, 2006.
Dr. Valérie Dubé, Clinical Fellow, supervised by Dr. Terry Colgan received the Best Platform Presentation Award at the
Annual U of T Department of Obstetrics and Gynecology Research Day in May 2006, for an oral presentation of her
paper: “The Toronto Endometrial Proteomic Initiative: towards discovery of new endometrial cancer biomarkers”.
Dr. Mock received a scholastic teaching award from the Alpha Omega fraternity, Toronto, 2006.
Dr. Anne Marie Mulligan, Clinical Fellow, supervised by Dr. Frances O’Malley has been selected as a faculty member
for the Toronto Breast Day Continuing Education Program.
Dr. Kenneth Pritzker was the recipient of the Karen McGibbon Award of Excellence together with Mount Sinai
Hospital Network of Knowledge Team affiliated with the Peter Silverman Centre for International Health, 2005.
CLINICAL SERVICES
Patient Services
Patient Services is one of Mount Sinai’s front doors with over 90,000 patients seen each year by our dedicated staff.
Over the year, space was secured and plans were advanced for enlarging our ambulatory care laboratory at 700
University Avenue.
Clinical Biochemistry
Maternal Serum Screening Program:
The Program continued to grow in size and complexity with the addition of a new biomarker inhibin A, conversion of the triple screen to the quadruple version, generation of first trimester Trisomy 18 and 13 risk, and
introduction of the first and second trimester integrated screen option.
The ability of the screens to predict better Downs’ Syndrome and other Trisomies was demonstrated after
linking screen risks to the karyotype outcome in the Cytogenetics database.
In Vitro Fertilization
Hormone testing was consolidated on the new Roche Modular automated analyzer, thereby simplifying specimen handling and facilitating rapid delivery of test results to the clinical service monitoring progress of the
developing follicle.
Reference Ranges
With medical leadership from Dr. Irv Bromberg, the Division of Clinical Biochemistry is continuing its efforts to
establish meaningful reference ranges for all analytes. Significant progress on this project has been made and
approximately 100 normal volunteers are now participating. We are currently in the stage of analyzing the
distributions for deriving reference ranges. We are also participating in a similar effort, initiated by the College
of American Pathologists.
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Hematopathology & Blood Transfusion
A new high speed flow cytometry cell sorter “BD FACSAria” was acquired. This will facilitate the research on
hemopoietic stem cells under the guidance of Dr. Wang.
Mr. Shahcheraghi successfully completed his MSc on the pathophysiology of anti-K haemolytic disease of the
newborn under the supervision of Dr. Denomme.
Dr. J. Pendergrast successfully completed the Royal College fellowship in Transfusion Medicine.
Dr. Hamid Jahanmahar is continuing his sabbatical working on computerized image analysis of malignant
lymphocytes. Dr. Jahanmahar is from Tehran University of Medicine Sciences, and assistant professor and director of
Hematology Laboratory in the Department of Clinical Laboratory Sciences.
This past year saw one of the biggest changes to date.
Newly acquired space was completely renovated to suit the needs of the biochemistry section. New supply cabinets
were built to specifically store the daily supplies required in the RRL. Items are clearly labeled and displayed resulting
in improved inventory control and management.
The entire middle section of the lab was renovated to accommodate the new Roche Modular platform which
went into operation in September. This system revolutionized how chemistry samples are now processed in that it
integrates all three phases – pre-analytics, analytics and post – analytics. The introduction of this system ensures
improved turnaround time for results reporting, less blood drawn on patients, backup and expansion capabilities.
The Roche Modular Analytical and Pre-Analytical Systems are now fully integrated into the clinical service and they
perform well. Additional analytical capabilities are realized by implementing automated ELISA platforms for specialty
testing and maternal serum screening programs.
The RRL was fortunate to also acquire additional equipment through the DME funding process. New coagulation
equipment is now operational and promises to be more cost effective and improve turn around times for results
reporting.
The transfusion medicine laboratory is seeing automation for the first time with the purchase of the Galileo Automated System, .scheduled to be implemented in November.
A new protein and urine electrophoresis analyzer introduced in May 2006 is more cost effective, more user friendly
and has cut down dramatically the time for results reporting.
The Auto Delphia replaces other platforms used for Prenatal Screening Testing and the NexGen has the ability to
automate some of our more labour intensive testing.
Pathology
A major thrust of activity in anatomical pathology was progress towards incorporation of synoptic reporting into
surgical pathology reports. As well, there were trends toward increased utilization of immunohistochemical
biomarkers related to expanded indicators for HER2 testing for breast cancer, as well as increased demands for
immunohistochemistry related to consultation cases.
Dr. Patrick Shannon, a neuropathologist with special expertise in perinatal pathology was welcomed to our
staff. As well as his other duties, Dr. Shannon will have responsibility for the adult autopsy service, as well as
administrative direction of ultrastructural pathology.
Cytopathology
Planning is underway to expand the capacity of the liquid-based cytopathology technology with more automated equipment.
Dr. Shabin Nanji, a cytopathologist with special interest in education and telepathology, has been recruited to
Pathology and Laboratory Medicine. Dr. Nanji joined Mount Sinai Hospital in October 2006.
Ultrastructural Pathology
Dr. Bédard initiated the Electron Microscopy Service at Mount Sinai Hospital in 1972. Over the past 34 years
under Dr. Bédard, this service has grown to be the most respected diagnostic electron microscopic service in
Canada. Many leading pathologists in Canada, who are experts in Electron Microscopy, trained as residents
with Dr. Bédard.
Dr. Patrick Shannon has assumed a role of Principal Consultant for this service, succeeding Dr. Yvan Bédard.
The Electron Microscopy Service continues to enjoy high utilization, particularly for examination of tumours,
kidney biopsies, connective tissues and crystal analysis.
Canadian Reference Centre for Cancer Pathology (CRCCP)
Under the direction of Dr. Theo van der Kwast, the CRCCP continues its role as a tumour reference centre
principally for pathologists in more remote communities in Canada. With Dr. Doug Tkachuk, Objective Pathology Services, discussion has started on a proposal to digitize the CRCCP cases to make these cases more
widely available throughout Canada.
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Laboratory Genetics
An active collaboration in Genetics has been established with the Lakeridge Health Centre. In Cytogenetics,
this has resulted in rearrangement of workload between Lakeridge Health Centre and Mount Sinai Hospital to
enhance services at both sites. Dr. Elena Kolomietz has been cross-appointed to Lakeridge Health Centre to be the
Laboratory Director of Cytogenetics.
Planning is underway to upgrade the software workstations for Cytogenetics. As well, Dr. Elena Kolomietz has
started exploration on the deployment of gene-based microarrays in Cytogenetics. This technology, comparative
genomic hybridization (CGH), has promise to identify genetic diseases not detectable by conventional Cytogenetics.
Gene probes using fluorescence in situ (FISH techniques) are used to identify genes in both Antenatal Cytogenetics
and in tumour tissues. Mount Sinai Hospital has received a grant from Roche Diagnostics to advance this
technology, with the goal of making the technique more robust and less time consuming.
In Molecular Genetics, an ABI-3130XL automated DNA sequencer was deployed together with DNA sequence and
fragment analysis software from Applied Biosystems, complemented by the Mutation Surveyor and Gene Marker
software packages from SoftGenetics. This equipment has accelerated the diagnosis of genetic abnormalities,
particularly in the Predictive Genetics of Cancer Program.
Pathology and Laboratory Medicine is collaborating with the Hospital for Sick Children and with Solutions by
Sequence, a company associated with Dr. Brenda Gallie, to provide retinoblastoma gene testing throughout
Ontario.
The implementation of Laboratory Information System Module “SoftGene” for Molecular Genetics is underway
with a “go live” schedule for late 2007.
Andrology
Plans are underway for expanding the ambulatory lab, as well as the Andrology Diagnostic Laboratory. Dr. Sergey
Moskovtsev has been recruited as a staff scientist for the Andrology Laboratory. New tests for specimen function
are being implemented. As well, a flow cytometer has been installed to provide tests to detect DNA fragmentation.
Rachel and David Rubinoff Bone and Tissue Bank
Over the past year, the Rubinoff Bone and Tissue Bank strengthened its capacity to provide more tissues under
stringent accreditation standards. The Rubinoff Bank is working with the Trillium Gift of Life to provide bone tissue
for applications throughout Ontario and beyond. These services are provided to other hospitals on a cost recovery
basis.
The Jeffrey Rubinoff Stem Cell Bank
This is a new bank designed to retain autologous haematopoietic tissues for future placement in the original donor.
Work on development of the bank is under the direction of Dr. Chen Wang. A key issue is decisions related to the
disease indications for cell storage banking and the appropriate point in the disease progression to harvest the cells.
To address these questions, Dr. Wang is investigating a class of lymphoproliferatiove disease, which by the available
biomarkers can remain quiescent for at least a decade.
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LABORATORY INFORMATICS
Laboratory Information System
In 1992 Pathology and Laboratory Medicine (PLM) made the strategic decision to find a single vendor solution for
its laboratory information systems for each laboratory section. Soft Computer Consultants (SCC) was chosen as a
vendor and in 1994 the first module (a Blood Bank system) was installed. Between 1996 and 2000 other modules
were installed for chemistry, hematology, microbiology and pathology. Between 2003 and 2004 the LIS underwent
a major upgrade (going live November 29, 2004) involving all areas of the laboratory. With this upgrade a beta
version of SoftGene was introduced to the LIS.
LIS updates have continued through 2005 / 2006, including a sequential upgrade of all the laboratory systems,
going LIVE June 15, 2006. SoftGene has been promoted from the beta product initially introduced, to a much
more robust information system for handling cytogenetics information.
The backend of the LIS was strengthened in 2005/2006, with an upgrade of the LIS servers (completed April 13,
2006) and the move of the LIS servers to the Markham data centre (March 13, 2006). The move the Markham data
centre ensures that the LIS information is stored and archived in a safe and reliable manner.
Expanded Interfaces
The main clinical laboratory underwent a major renovation in 2005/2006. With this renovation a number of new
analytical machines were introduced to the laboratory. The interface to the Roche analytics and per-analytics was
implemented in September, 2005 and the interface to the Biorad Variant II was implemented in May 2006.
Citrix Support
Pathology and Laboratory Medicine has worked to allow all the professional staff remote access to network drives
and the Laboratory Information System via a Citrix solution. Following corrections found in the pilot project, the
Citrix solution has allowed the access to crucial files and information from remote locations around the world.
The introduction of the Citrix solution has also allowed several pathologists and support staff to work off-site.
Web Site/Communications
Pathology and Laboratory Medicine has worked in connection with Mount Sinai Public relations to create a distinct
web site. Part of this project was the joint supervision of a communications student (Keefe Lee) for web site
development. In addition, PLM is working with the Mount Sinai library to assist in the development of web site
content and other departmental communications.
The initial web site went live in the spring of 2005. Further enhancements have been made to the site and the
content has been enriched since the initial site was launched.
Mr. Keefe Lee has continued to develop departmental communications media and is working on developing
products for PLM research services.
Paradigm Document Control System
Controlling the hundreds of documents within PLM is a monumental task. To assist with management of the
laboratory documentation, the Paradigm Document Control System was introduced June 1st, 2006. As part of
this system all members of PLM have access to necessary documents through a web interface. Using this system
it should be possible to ensure that all members of the staff are using the current and most up to date version
of Standard Operating Protocols. This program should also help assist with the continual document review and
updating that occurs within Pathology and Laboratory Medicine.
Digital Imaging
Pathology and Laboratory Medicine has continued to move from traditional photography to digital imaging
solutions. All gross images are taken with digital cameras and the vast majority of photomicrographs are taken
digitally (all pathologists have digital cameras and a shared digital camera is available for residents).
Pathology and Laboratory Medicine is also continuing to evaluate and consider a number of solutions to handle the
growing number of digital images. Finding the solution to handle all of PLM’s digital needs is not a trivial matter.
Investigation into possible solutions is ongoing.
Digital X-Rays
A system to capture digital X-Rays was introduced in 2006, moving PLM to essentially complete digital imaging. As a complete digital imaging management solution for the department has not yet been implemented,
an interim solution using a picture archiving and communications system (PACS) has been introduced for the
digital X-Rays.
Digital Slide Scanning
A complete slide scanner was introduced to PLM in 2006. This system incorporates technologies from a
variety of companies, including software from Visiopharm that has advanced capabilities in image analysis and
morphometry.
The digital slide scanner has also been introduced to assist with the interpretation of the tissue slide microarrays that are being produced within the department. Using the slide scanner and microarray software it
should be possible to capture individual images of all the cores within the microarray. These images will then
be incorporated with the data from the cores, allowing both local and distant interpretation and analysis of
our microarray data.
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RENOVATIONS & RELOCATIONS
The expanded Rapid Response Laboratory was opened on December 19, 2005 by Mr. George Smitherman, Minister of Health of Ontario in conjunction with his announcement of the Designated Medical Equipment funding for
laboratory services. The highlight of the Rapid Response Laboratory expansion is the Roche chemistry system. This
fully automated system includes extensive pre-analytical automation as well as automated chemistry and immunochemistry analyzers all linked by an automated specimen conveyor system. The pre-analytical component consists
of centrifuges and specimen aloquoting system. This facility is amongst the most advanced in the world. Early
experience indicates that this instrumentation is fulfilling its promise of decreasing labour and decreasing turnaround time. With the relocation of the Sysmex hematology system to be immediately adjacent to the chemistry
system, the Rapid Response Laboratory is even more capable of providing fast, efficient service at all times. In the
next phases of this project, space will be made available for new specialized chemistry analyzers, new coagulation
instruments, an automated blood bank system and new refrigerated storage.
This project was accompanied by the completion of the HVAC renovation of this portion of the laboratories, and
the installation of a sprinkler system. These features have greatly enhanced the capacity and flexibility of the Rapid
Response Laboratory.
In June 2006 Dr. Eleftherios Diamandis relocated his research laboratories to the Koffler Centre at 60 Murray Street.
These laboratories will be adjacent to the clinical facilities for the Koffler Centre for Men’s Health as well as the
research genetics facilities associated with Drs. Bharati Bapat, Steve Gallinger and Hilmi Özçelik all of whom are
members of Pathology and Laboratory Medicine.
Over the current year Mount Sinai Hospital embarked on a plan for capital renewal which includes both short term
and long term capital planning.
In the short term, Pathology and Laboratory Medicine is planning facilities for its Andrology Ambulatory Laboratory,
renovation/expansion of the 3rd floor ambulatory lab at the Ontario Power Generation building to accommodate
the expansion of the Women’s Program. As well, facilities for flow cytometry, a specialized facility to enable protein
extractions, a facility to house an advanced, high resolution, specialized x-ray machine, space for morphometry
including tissue microarray, and expansion of laboratory genetics space are planned.
In the longer term a comprehensive plan for renovation/expansion of Histology and Autopsy facilities is planned as
well as more definitive and purpose built space for laboratory genetics.
QUALITY PROGRAMS
Accreditations, Regulatory Certifications/Registrations
The pursuit of high quality in all our activities for the benefit of our patients, students and clients is a continuous
endeavour within Pathology and Laboratory Medicine. The year was marked with significant enhancement in
developing a core set of laboratory patient safety goals for pre- and post-analytic laboratory processes such
as patient/sample identification, verification & communication of life threatening or life altering information,
identification/communication/correction of errors and more importantly coordination of the laboratory patient
safety role within the hospital.
The accreditations and quality programs listed below reflect Pathology and Laboratory Medicine’s deep
commitment to quality:
• Laboratory Accreditation Program (LAP), College Of American Pathologists, On-site inspection June 3, 2005.
Fully accredited until June 27, 2007.
• Ontario Laboratory Accreditation Program (OLA) based on ISO 15189, Quality Management Program
– Laboratory Services (QMP-LS), Ontario Medical Association (OMA). Successfully completed January 28, 2004.
Certification valid until May 28, 2009.
• Laboratory License # 4194, Ministry of Health and Long-Term Care, Ontario. Issue date April 02, 2006.
• Acute Care Standard-8 (Laboratory), Canadian Councils For Health Services Accreditation (CCHSA), Hospital
Acute care Standards, January 16 -18, 2006.
• American Association Of Tissue Banks (AATB), Re-accredited June 9, 2004 Musculoskeletal Tissue Program
with Level À’. Expires June 15, 2007.
• Food and Drug Administration, Department of Health and Human Services, U.S. Good Laboratory Practice
(cGLP) standards for clinical and pre-clinical research laboratory services based on U.S. Federal Register, 21 CFR
Part 58.
• Certificate Of accreditation in Medical Laboratory Technology Training. The Michener Institute for Applied
Health Sciences and Partner Sites, 2003.
• Canadian College of Medical Genetics Accreditation - approval to 2008. CCMG Committee. Recognized
training site for cytogenetics technologists and cytogeneticists.
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External Quality Assessment Programs
• Surveys & Anatomic Pathology education programs, College Of American Pathologists. 325 Waukegan Road,
Northfield, IL 60093-2750. Inter-laboratory Proficiency Testing Surveys, Q-probes & Education Case Studies:
Biochemistry, Hematopathology, Transfusion Medicine, Immunopathology, Flow Cytometry, Anatomic Pathology
-Performance Improvement Program, Cytopathology- cervicovaginal & Non-Gynae, Cytogenetics, Point-Of-Care
Testing, Cytogenetics, Molecular Pathology, Andrology, Maternal Serum Screening, Instrumentation, Linearity
surveys etc. Audio conferences, Laboratory Inspection Checklists
• Quality Management Program – Laboratory Services (QMP-LS), OMA, Toronto
Mandatory External Quality Assessment Program (EQA). For complete Testing Program, visit QMP-LS website.
http://www.qmpls.org
• The European Molecular Genetics Quality Network (EMQN), National Genetics Reference Laboratory, c/o
Regional Molecular Genetics Laboratory, St Mary’s Hospital, Hathersage Road, Manchester M13 0JH, UK.
EQA registrations: Hereditary non-polyposis colon cancer, Y-Chromosome microdeletion
• Fetal Medicine Foundation: The Fetal Medicine Centre, 137 Harley Street, London WIG 6BG, U.K.
• Vitamin D External Quality Assessment Scheme (DEXAS), London, UK
• American Society for Clinical Pathology (ASCP). Continuing Education Programs Teleconferences, 2005 -2006.
ASCP, 2100 West Harrison Street, Chicago IL 60612.
• Clinical and Laboratory Standards Institute (formerly NCCLS)
Training & Competence Assessment; GP21-A2, 2004
Handling & processing of blood specimens, H18-A3, November 2004.
Clinical Laboratory Safety; GP17-A2, 2004; M29-A2; GP5-A2
Dangerous Good Regulations (TDGR, IATA), TDG Clear language -2004
Application of Quality Management System Model for Laboratory Services, GP26-A3, HS1-A2
Molecular Methods (SC25-L), Molecular Diagnostic methods for genetic diseases–MM1A.
Fluorescence In Situ Hybridization (FISH) methods for Medical Genetics proposed guideline MM7-A, 2004
Laboratory Documents, GP2-A5, 2006.
• Continuous Quality Improvement: Essential Management Approaches, GP22-A2
• Basic Safety Requirements for Human Cells, Tissues and Organs for Transplantation’ Guidance Document – July
2005. Health Products and Food Branch, Health Canada.
• Human Cells, Tissues, and Cellular and Tissue-based products – FDA 21 CFR Part 1271
Current Good Tissue Practices (GTP) Final Rule, 2004.
• Schulich School Of Business, York University, Toronto, Ontario, Canada.
Management Leadership (Executive Development) sessions for laboratory management, January,2006:
Èssential Skills To Achieve A Conflict Free Work Environment’
May, 2005: `Strategic Mindset In-Company Workshop’
April 2004: Ìmproving Personal & Team Leadership Dynamics’
• Clinical Laboratory Management Association (CLMA): Teleconferences `Management Leadership’ series. CLMA
Executive Office, 989 Old Eagle School Road, Suite 815, Wayne PA 19087.
Continuous Quality Improvement Activities: Indicators
In our continuing efforts to improve laboratory processes, numerous of quality indicators were monitored and
posted on our internal network.
Quality Management Team Activities: 2005-2006
• CAP Laboratory Accreditation inspection successfully completed on June 3rd, 2005
compliance to the industry requirements
with 98.7%
• Implementation of document management software `PARADIGM II’ (In-progress)
• QMS Team completed full documentation (policy-process-procedure and mechanism to document) on two
Quality System Essentials (QSEs)
a. Service & Satisfaction
Laboratory service satisfaction survey was carried out with overall rating of
`Very Good’ laboratory services.
b. Occurrence Management: a complete review and revision of incident documentation process was
carried out in keeping with the hospital process and revised patient safety goals.
• Self-assessment of Rubinoff Bone & Tissue Bank against new Health Canada guidelines released July-2005.
• Standard 8, the Canadian Council on Health Services Accreditation (CCHSA)
Successfully completed for the hospital 2006 accreditation visit.
• Laboratory safety committee reviewed and completed HIROC (Health Insurance Reciprocal Of Canada) survey
(Modules: Orientation, POC,Privacy), MSH’s insurer.
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EDUCATION
Educational Activities July 2005 – June 2006
Pathology and Laboratory Medicine continues to be actively involved with education at several levels, from continuing education for medical professionals to providing experiences for high school students. All medical, scientific
and support staff are strongly encouraged to participate in education activities.
Education Committee
The education committee consists of Drs. Aaron Pollett, Christina MacMillan and Terry Colgan. The committee
meets as required throughout the year to discuss various components of undergraduate, resident, fellow and postgraduate medical education at PLM. Dr. Christina MacMillan continued to organize educational rotations for core
pathology and visiting residents and medical students. Dr. Aaron Pollett continued to organize clinical fellowships
for core and visiting post-residency fellows at PLM.
All three members form the core of the fellowship selection committee.
Medical Education
Undergraduate Medical Education
Our staff continues to participate in the year II Pathobiology of Disease Course, supplying six tutors for small
group instruction, as well as participating in lectures and conducting laboratory sessions. The tutors for the
2005 Pathobiology of Disease course were Drs. Aaron Pollett, Anita Bane, Anna Marie Mulligan, Robert Riddell, Niki MacNeill and Anne-Marie O’Shea.
Dr. Azar Azad teaches in the nutrition course of the Undergraduate medical curriculum.
Dr. Barry Hoffman is the course coordinator for the Pathobiology and Clinical Biochemistry course for Pharmacy (PAT331H / PHM330Y).
Elective Students
Medical students are encouraged to take part in all educational activities within PLM and are welcome to
spend elective time in the various pathology disciplines. Our medical student electives included Nathalia Torres, Susan James and Ilse van den Bosch (Netherlands).
Postgraduate Medical Education
Pathology and Laboratory Medicine continues to offer a series of rounds, conferences and seminars throughout the year (a sample schedule is given in Appendix I). Resident participation in rounds and education events,
including provincial, national and international meetings is strongly encouraged.
All staff have been involved with the education of residents, both from pathology programs and elective residents from a variety of other disciplines. Notable examples include Dr. Terry Colgan’s and Dr. Sarah Keating’s
teaching of residents within Obstetrics and Gynecology and Pathology and Laboratory Medicine’s support in
the training of Radiology residents.
Dr. Bernard Fernandes and Dr. Barry Hoffman continue to act as the residency program directors for Haematological Pathology and Clinical Biochemistry, respectively.
In the past year, Pathology and Laboratory Medicine has welcomed the following residents:
Anatomic, General Pathology and Clinical Biochemistry:
Dr. Brendan Dickson (Anatomic Pathology, Sarcoma, Cytopathology)
Dr. Elizabeth Timonera (Anatomic Pathology)
Dr. Vidhya Nair (Anatomic Pathology)
Dr. Kristopher Cunningham (Anatomic Pathology)
Dr. Khaldoon Aljerian (Anatomic Pathology, Sarcoma)
Dr. Mohammad Jaragh (Cytopathology, Head and Neck Pathology)
Dr. Ahmed Arwini (Cytopathology)
Dr. Mubarak Al-Shraim (Sarcoma)
Dr. Lily-Naz Hazrati (Sarcoma)
Dr. Daniel Winer (Sarcoma)
Dr. Bojana Djordjevic (Gyne Pathology, Sarcoma)
Dr. Meagan Kennedy (Breast Pathology)
Dr. Ilan Weinreb (Sarcoma / Bone pathology)
Dr. Ken Craddock (Anatomic Pathology)
Dr. Charis Kepron (Anatomic Pathology)
Dr. Jamil Asaria (Sarcoma – research)
Dr. Dina El Demellawy (Anatomic Pathology, Cytopathology)
Dr. Quoc Hung Huynh (General Pathology)
Dr. Catherine Chung (Breast pathology)
Dr. Kalawathy Sivarajah (Clinical Biochemistry)
Dr. Lalitha Gunapalan (Clinical Biochemistry, Hematopathology)
Pathology Residents from Other Locations
Dr. Domenic Akpan, Nigeria (Surgical Pathology)
Dr. Hameed Aljawad, McMaster (Sarcoma)
| 21
Residents from other programs:
General Surgery
Dr. Sundeep Rai
Dr. Daphna Barsuk
Dr. Karen Devon
Dr. Pavi Kundhal
Dr. Sal Privitera
Medical Genetics
Dr. Hanna Faghfoury
Obstetrics and Gynecology
Dr. Colleen McDermott
Dr. Ari Baratz
Dr. Nihal Al-Riyami
Dr. Sabrina Lee
Dr. Eve Fried
Dr. Neelam Sierra
Dr. Susan Kim
Dr. Kerry Wilson Myckan
Dr. Rachel Spitzer
Radiology
Dr. Ida Chan
Clinical Fellows
Pathology and Laboratory Medicine has continued to be successful in attracting international fellows. In the
past year, our department has welcomed the following Laboratory Physicians:
Dr. Anita Bane (Ireland), Breast Pathology (PhD candidate)
Dr. Anna Marie Mulligan (Ireland), Breast Pathology
Dr. Anne-Marie O’Shea (Ireland), Gastrointestinal Pathology
Dr. Da-Elene van der Merwe (South Africa) - Clinical Biochemistry
Dr. Facundo Las Heras (Chile), Bone Pathology; PhD candidate – Institute of Medical Sciences
Dr. Michael Curtis, Cytopathology
Dr. Valerie Dube, Gyne Pathology
Dr. Niki MacNeill, Gyne Pathology
Dr. Richard Kirsch (South Africa), Gastrointestinal Pathology
Dr. David Good, Hematopathology
Dr. Abdel Alwraikat, Hematopathology
Dr. Nusrat Hussein
Fellows in Clinical Biochemistry
Dr. Isolde Seiden-Long
Dr. Hui Li
Dr. Sergei Likhodii
The Alan Pollard Award for Scientific Achievements by a Post-Doctoral Diploma Program
Trainee
To honour Dr. Alan Pollard’s distinguished contribution as head of Clinical Biochemistry at Mount Sinai
Hospital for over 28 years, the Alan Pollard Award was established. This award recognizes the Clinical Biochemistry trainee who has submitted for presentation the most distinguished paper. The award
consists of travel expenses to a major meeting to present the research findings. The awardee for 2005 is
Dr. Paul Yip.
Fellows from other programs:
Dr. Rebecca Gladdy (Surgical Oncology)
PLM teamed with the University Health Network and the Hospital for Sick Children to create a tri-hospital Gastrointestinal pathology fellowship program. The supervisors at PLM are Drs. Robert Riddell and
Aaron Pollett. This program continued into 2005 – 2006 with Dr. Richard Kirsch receiving the fellowship
position.
Dr. Sarah Keating continued her dedicated Perinatal Pathology rotation for clinical fellows in MaternalFetal Medicine through the past year. Dr. Karen Bishop spent extended time in perinatal pathology.
Cytogenetic Fellows
PLM welcomed a cytogenetics fellow, Dr. Anne George.
| 23
Continuing Medical Education
Dr. Terence Colgan continued as Co-Director of the University of Toronto Annual Pathology Update Course
though November 2005. This pathology update course is one of the largest pathology CME events hosted by
the University of Toronto.
Dr. Iona Leong continued to coordinate the Head and Neck Group Pathology Rounds she initiated in 2002.
These rounds are a monthly educational event for regional anatomic and oral pathologists focused around
interesting head and neck pathology. These rounds are hosted by Pathology and Laboratory Medicine.
Pathology and Laboratory Medicine staff continues in a variety of specialty clinical rounds on a regular basis,
including several rounds that are driven by members of our department. These rounds include:
Breast Tumour Board:
General Surgery/Gastrointestinal Rounds:
Inflammatory Bowel Disease Rounds:
Sarcoma Tumour Boards:
Head and Neck Rounds:
Neonatal Rounds:
Gynaecologic Pathology:
Gastrointestinal Tumour Board:
Urology Tumour Board:
Andrology Rounds:
Dr. Frances O’Malley
Dr. Robert Riddell
Dr. Robert Riddell
Dr. Rita Kandel
Dr. Dave Howarth
Dr. Kenneth Pritzker
Dr. Christina MacMillan
Dr. Sarah Keating
Dr. Patrick Shannon
Dr. Terence Colgan
Dr. Aaron Pollett
Dr. Theo van der Kwast
Dr. Brendan Mullen
Harold G. Pritzker Memorial Lecture 2006
Harold Goldsmith Pritzker was the Pathologist-in-Chief at Mount Sinai Hospital from 1938 to 1963. Upon his
death, his colleagues in all disciplines established an Annual Memorial Lectureship Fund, which was transferred to the Academy of Medicine. A committee was created, which included representatives of the founding bodies, namely the Academy of Medicine, Mount Sinai Hospital and the University of Toronto. With the
demise of the Academy of Medicine in 1992, the Annual Memorial Lecture continued with the generous support of the hospital administration and the Department of Pathology and Laboratory Medicine of Mount Sinai
Hospital. The initial lecture was delivered in 1965. Throughout the years, this lecture has become one of
the most distinguished lecture series attracting some of the most celebrated names in Pathology and related
fields.
The guest lecturer for the 41st Annual Pritzker Memorial Lecture was Professor Olli Kallioniemi from Finland,
who presented “Translational Cancer Systems Biology” April 24th, 2006.
Research Student Programs
Undergraduate Research
Pathology and Laboratory Medicine continued to provide summer research experience for undergraduate
students. A total of 19 summer students were at PLM over the summer of 2006 under the supervision of 15
different staff members. The list of summer students with their supervisors and titles/projects is presented in
Appendix H.
Faculty of Applied Science and Engineering Undergraduate Project Students, Nanotechnology
In 2005-2006, Dr. Kenneth Pritzker supervised two students:
Ms. Grace So, Materials Science and Engineering:
Thesis title “Characterization of Hydrophobic Fullerene Derivatives and Liposome Formulations for Potential Applications in Photodynamic Therapy”
Mr. Lawrence Lee, Engineering Science:
Thesis title “Characterization and Gold-Doping of Hexadecaanilinated Carbon Nanotubes”.
Faculty of Arts and Sciences, Laboratory Medicine and Pathobiology,
Undergraduate Project Students
In 2005-2006, Dr. Kenneth Pritzker supervised Mr. Jovil Kanampuza in his studies on effects of alkaline phosphatase of calcium pyrophosphate dihydrate crystal dissolution.
Dr. Rita Kandel supervised Mr. Edward Hadzocos, project title: p53 and benign breast disease”; and Mr. Igal
Raizman, project title: “Mechanical stimulation and its effect on the different zones of cartilage.
Graduate Students
Forty-six graduate students are under the supervision of 8 PLM staff. A list of graduate students with their
project titles and supervisors is presented in Appendix D.
We are proud to have several award winners among our graduate students, including:
Facundo Las Heras (Kenneth Pritzker), ACE Trainee studentship award
Miralem Mrkonjic (Bharati Bapat), MSc LMP Award (Graduate student research day)
In addition to direct supervision of graduate studies, the staff also coordinate numerous graduate courses offered by the University of Toronto, including:
LMP1016 Pathology of Connective Tissue (Dr. K.P.H. Pritzker)
LMP 1407 Introductory Biostatistics and Clinical Investigation (Dr. R. Veith)
LMP 1506 Techniques in Functional Genomics and Proteomics (Dr. E. Diamandis)
| 25
Postgraduate Students
Twenty-one postdoctoral students are currently pursuing research studies in Pathology and Laboratory Medicine. A list of postdoctoral students with their project titles and supervisors is listed in Appendix G.
Technical Education
Medical Laboratory Science Program
This program includes training in microbiology, blood transfusion services, haematopathology, biochemistry
and histotechnology. A total of eight students from three different programs undergo portions of clinical
training at PLM.
St. Lawrence College
Emily Dabous, Connie Pearson, Gefei Wang
The Michener Institute
Bjorn Greppmayr, Wei Liu, Lisa Manning and Catherine Pandy
Mohawk College
Mohammed Ghannam (short program for foreign graduates)
Discussions are underway with the Medical Laboratory Science Program of the Ontario Institute of Technology
to provide clinical experience for their students.
Mount Sinai Hospital is also engaged in teaching cytopathology students from the Michener Institute related
to changes in curriculum. No students were present at MSH over the past year.
Genetics Technology
Three students in the Genetic Technology Programme underwent their clinical rotations at Mount Sinai Hospital. The students were:
Ana Baptistia
Kayu Chin
Nadine Sharpe
Mark Ballantyne
Amanda Fowler.
Starting in 2004, John Tzountzouris has been appointed the clinical coordinator for the Molecular Genetics
Rotations and he continued in this role through 2005.
Continuing Education: Technical and Support Staff
Technical and support staff are strongly encouraged to attend courses, seminars, lectures and conferences and
congresses. In 2005 / 2006 60 staff members were sponsored for over 90 courses and seminars.
Continuing education via teleconference is offered to all staff (the list of teleconferences offered in 2005 /
2006 is given in Appendix J).
Monthly In-Service Education sessions for the histotechnology and cytotechnology staff continue to be well
attended. These sessions are coordinated by Jan Church and have included presentations delivered by the
departmental technical and professional staff.
Monthly Genetics Educations Sessions, presented by scientific experts in the field are provided for all PLM
technical genetics staff. These rounds were initiated by John Tzountzouris in 2003 and continued through the
2005 / 2006 academic year.
Schulich School of Business Education Opportunities
These Schulich courses are organized under the leadership of Mr. Vince D’Mello and are designed to
enhance the management skills of our staff. One course was offered to members of the PLM in 2005
– 2006:
“Working Towards a Conflict Free Work Environment”, January 12th and 13th, 2006, attended by 23
staff members.
Volunteer Student Program
Several high school students spent up to five months at Pathology and Laboratory Medicine, predominately
in the Cytopathology and Surgical Pathology sections. This very successful co-operative programme exposes
these students to observe, at an early stage, the important role played by laboratory medicine in the diagnosis
and management of patients. After completion of the programme, the students usually receive a high school
credit or an Ontario Academic Credit (OAC).
With the Volunteer’s Office, volunteers are encouraged to observe and assist in the laboratories. Occasionally,
these volunteers are high school students but, more frequently, are university undergraduates seeking additional exposure to a medical environment.
| 27
SPONSORED RESEARCH AND INNOVATION
Research and Innovation continues principally in cancer diagnostics, articular skeletal diseases and bioengineering,
fetal and perinatal diseases and genetics. Much of this work is collaborative, internally with clinical colleagues
and with investigators at the Samuel Lunenfeld Research Institute and externally with colleagues in similar
fields worldwide. The activities, although in a few select areas, do range from fundamental research through
translational research, introduction of innovation and reduction to practice. This is reflected in the broad range of
public and corporate sponsors of the Research and Innovation activity within Pathology and Laboratory Medicine.
Investigator
Granting Agency
Title
Amount
Dr. I. Andrulis
Canadian Institutes of Health
Interdisciplinary health research team in
$252,430
Dr. R. Bell (PI)
Research
musculoskeletal neoplasia
et al
Dr. I. Andrulis
Ontario Cancer Research Network Identification of novel prognostic markers and
Co-PI with
$133,561
therapeutic targets in osteosarcoma
Dr. J. Wunder
Dr. I. Andrulis
Canadian Breast Cancer
Use of CGH arrays to identify genes involved in
$92,326
Co-PI with
Foundation
breast cancer
Dr. I. Andrulis
Canadian Breast Cancer Research
Screening behaviors and outcomes among relatives
Dr. A.M. Chiarelli (PI)
Alliance
of women with breast cancer
Dr. I. Andrulis
Canadian Breast Cancer Research
Association of lipid gene haplotypes with breast
Dr. J.M. Rommens (PI)
Alliance
density and cancer
National Institutes of Health
The role of the ATM gene in familial breast cancer
$23,000
Dr. B. Bapat (PI)
Role of Rac1 GTPase in regulation of Wnt pathway
$106,014
Dr. L. Briollais
Research
in colon cancer
Dr. B. Bapat (PI)
Ontario Cancer Genetic Network
Predisposition to Colon Cancer Program
$12,715
Dr. B. Bapat (PI)
Canadian Prostate Cancer
MYH mutations and prostate cancer risk
$50,000
Dr. N. Fleshner
Research Initiative-Idea Grant
Dr. J. McLaughlin (PI)
A program of interdisciplinary and population based
$115,572
Dr. B. Bapat et al
Research
studies of the determinants and impact of colorectal
Dr. T. Colgan
National Cancer Institute of
Biomarker discovery, identification and verification
Dr. M. Siu (PI)
Canada
using tissue proteomics in an endometrial cancer
Drs. S. Bull &
Dr. F. O’Malley
$196,966
P. Ritvo, N. Klar,
J, Knight, F. O’Malley
$312,413
N.F. Boyd, A.D.
Paterson,
M.J. Yaffe, I. Andrulis
Dr. Chenevix-trench (PI)
Dr. I. Andrulis
cancer. A genetic epidemiological approach.
Dr. A. Romaschin
model
$149,210
Investigator
Granting Agency
Title
Amount
Dr. T. Colgan
Diagnosis of endometrial cancer
$149,570
Dr. M. Siu (PI)
(CIHR) Proof of Principle
$50,000
Dr. A. Romaschin
Dr. G. Denomme (PI)
Canadian Blood Services Kenneth
Blood group DNA genotyping: Meeting the demand
Drs. J. Callum,
J. Fyke Award-2004 Competition
for antigen- specific blood
Dr. G. Denomme
Small Project Fund Canadian
Analysis of ABO discrepancies
$6,400
Dr. W. Lau (PI)
Blood Services
Dr. G. Denomme
HPA genotyping platelet apheresis donors
$14,190
Dr. N. Shehata (PI)
Blood Services
HPA alloantibodies in platelet apheresis donors
$14,940
RHD alleles in prenatal patients
$12,917
$66,000
J. Pendergrast
Drs. J. Freedman,
Dr. G. Denomme
Dr.J. Freedman (PI)
Blood Services
Drs. N.S. Shehata
Dr. G. Denomme
Dr. J. Hannon (PI)
Blood Services
Drs. G. Clarke,
J. Ashdown, G. Barr
Dr. G. Denomme (PI)
Intramural Grant Canadian Blood
Soluble recombinant Dombrock and Lutheran
Dr. W. Sheffield
Services
blood group antigens: Towards improved care for
Dr. E. Diamandis (PI)
NSERC/University of Toronto(with
alloimmunized transfusion recipients
Kallikreins as disease biomarkers
Oncotherapeutics)
($210,000)
Dr. E. Diamandis
Prospective evaluation of prostate biopsies for
Dr. R. K. Nam (PI)
Canada
prostate cancer detection
Dr. E. Diamandis
National Multiple Sclerosis Society
Range of action of the kallikrein gene family in MS
Dr. I. Scarisbrick (PI)
Dr. E. Diamandis
Dr. E. Diamandis
$150,000
$133,000
$189,150
pathogenesis
NSERC/University (with IBEX
Biological functions of human kallikrein 14 - A novel
Technologies Inc)
serine protease
National Cancer Institutes of
Diagnostic utility of the normal epithelial specific 1
Canada
gene (NES1) in ovarian cancer
Dr. Julinor Bacani (PI)
Terry Fox Foundation Post MD
Frequency of E-cadherin (cdh1) and mismatch repair
Dr. S. Gallinger
Fellowship
(MMR) germline mutations in young gastric cancers
$120,000
$58,500
$48,038
in Southern Ontario
Dr. S. Gallinger
Dr. G. Petersen (PI)
(USA)
Pancreatic cancer linkage consortium
Dr. S. Gallinger (PI)
Ontario Cancer Research Network Improving care and research in pancreas cancer in
$120,000
$123,333
Ontario - A population-based study
Dr. S. Gallinger
Genome Canada
Dr. B. Zanke (Co-PI)
The ARCTIC (Assessment of risk for colorectal
$50,000
tumors in Canada) Genome Project
Dr. T. Hudson (Co-PI)
Dr. S. Gallinger (PI)
The MYH gene and colorectal cancer risk
$141,000
et al
Canada
Dr. M. Grynpas (PI)
National Science & Engineering
Mechanisms of degradation of calcium
$30,800
Research Council of Canada
polyphosphates
| 29
Investigator
Granting Agency
Title
Amount
Dr. W.I. Stanford (PI)
The role of stem cell antigen-1 (Sca-1) in bone
$123,987
Dr. M. Grynpas
Research
development and homeostasis
Dr. A. Jurisicova (PI)
Importance of harikiri in regulation of oocyte and
Dr. M. Grynpas
Research
embryo survival
Dr. M. Grynpas (PI)
Maintenance and support for the Advanced
Dr. S. Quaggin et al
Research
Bioimaging Centre
Dr. M. Grynpas
The clinical utility of the mechanical response.
Dr. A.M.W. Cheung (PI)
Research
Tissue analyzer device for determining bone fragility
Dr. M. Grynpas
Identification of genes responsible for human bone
Dr. J.E. Aubin (PI)
Research
disease through mouse mutagenesis
Dr. M. Grynpas (PI)
Can Vitamin D delay or arrest the progression of
Dr. R. Vieth
Research
osteoarthritis
Dr. R. Kandel (PI)
Development of biological implants for joint repair
$237,008
Dr. M. Grynpas et al
Research
Dr. R. Kandel
Canadian Institutes of Research in
Independent health research team in
$50,000
Dr. R. Bell (PI)
Musculo- skeletal Health Research musculoskeletal neoplasia
Dr. J. Aubin
$90,326
$100,000
$78,500
$232,542
Dr. W.G. Cole et al
$63,136
Dr. R. Kandel
Dr. I. Andrulis et al
Dr. R. Kandel
Dr. T. Rohan (PI)
p53 in BBD and breast cancer risk: A multicenter
$139,447
cohort
et al
Dr. R. Kandel (PI)
The Arthritis Society
Dr. K. Siminovitch
Factors regulating formation of bioengineering
$64,514
articular cartilage
Dr. R. Kandel (PI)
National Science & Engineering
Bioengineering a modular intervertebral disc
$136,627
Drs. M. Grynpas, M.
Research Council/ Canadian
Hurtig,
Institutes of Health Research
Bioengineering annulus fibrosus using silk scaffold
$135,000
Canadian Arthritis Network
Development of tissue-engineered joint surface
$23,500
R.M. Pilliar, J.P.
Santerre,
S.D. Waldman
Dr. R. Kandel (PI)
Drs. M. Grynpas,
R. Kandel, G. Pilliar
G. Vunjak-Novkovic
Dr. R. Kandel
Dr. R. Pilliar (PI)
replacements
Drs M. Grynpas,
R. Kandel, P. Zalzal,
J. Medley, M. Hurtig
Dr. F. O’Malley
Dr. I. Andrulis (PI)
Dr. Norman Boyd
et al
Ontario Family Registry for studies of breast cancer
risk
$182,786
Investigator
Granting Agency
Dr. F. O’Malley
Title
Identification and clinical importance of novel
Amount
Canada - Terry Fox Program
genes/pathways involved in ANN breast cancer
Dr. S. Bull
Project
Dr. F. O’Malley
Evaluation of the effectiveness of nurse examiners in
Dr. A. Chiarelli (PI)
Foundation
an organized screening program
Dr. F. O’Malley
Use of CGH arrays to identify genes involved in
Foundation
hereditary breast cancer
BRCA2 associated breast cancer: Histopathologic
Foundation
phenotype & molecular profile
Prognosis in BRCA1 associated breast cancer
$45,177
Genetic polymorphisms and radiation sensitivity in
$40,210
$191,334
$47,416
et al
$99,951
et al
Dr. F. O’Malley (PI)
Dr. F. O’Malley
$99,238
Dr. P. Goodwin (PI)
Dr. I. Andrulis, et al
Dr. H. Ozcelik
Drs. Katherine Vallis/
breast cancer patients
Anne Kosch (PI)
Dr. H. Ozcelik (PI)
Dr. H. Ozcelik (PI)
Dr. K. Pritzker (PI)
Prostate Cancer Research
DNA repair SNP profiles and response to prostate
Foundation of Canada
cancer radiotherapy
$60,000
Cross-talk between DNA repair SNPs and additive
Foundation
breast cancer risk
Ontario Cancer Genetics
Genetic DNA Registry
$344,693
Maintenance of core robotics facility
$90,497
$300,000
$96,939
Network-Research
Dr. K. Pritzker
Dr. J. Wrana (PI)
Research
et al
Dr. K. Pritzker
Canadian Institutes of
Molecular mechanisms of pain and fatigue in
Dr. J.L. Henri (PI)
Health Research Institute of
osteoarthritis: interplay between nerve and joint
Musculoskeletal Health & Arthritis
Dr. K. Pritzker
ACE Trainee Committee
Dr. F. Las Heras
University Health Network/
Studenship Award
$7,500
Effect of 156 weeks of treatment with MK-0966
$101,922
Toronto Western Hospital
Dr. R. Riddell
Merck Frosst
on the recurrence of neoplastic polyps of the
large bowel in patients with a history of colorectal
adenomas
Dr. T. van der Kwast (PI)
European Randomized Study of
Prostate cancer screening related research
$50,000
$240,000
Screening for Prostate Cancer
Dr. T. van der Kwast (PI)
Zorg Onderzoek Nederland
Cost-effectiveness fo the follow-up of patients with
Dr. E.C. Zwarthoff
Medische Wetenschappen
superficial bladder cancer
Dr. R. Vieth
Evaluation of the use of vitamin K in
Dr. A.M. Cheung (PI)
Research
postmenopausal women with osteopenia-ECKO trial
et al
$152,563
| 31
Investigator
Granting Agency
Title
Amount
Dr. R. Vieth
A study of normal light exposure and melatonin in
$325,665
Dr. J. Knight (PI)
Research Initiative
healthy women
Dr. R. Vieth
Dairy Farmers of Canada
Genetics influences on the variability of responses to
Dr. David Cole (PI)
Dr. R. Vieth (PI)
$55,000
vitamin D supplementation
Dairy Farmers of Canada
Dr. D. Rousseau
Bioavailability of Vitamin D from fortified cheese, ice
$38,000
cream and yogourt
Dr. C. Wang
Phenotype-driven generation and analysis of mouse
Dr. W. Stanford (PI)
Research
models of hematological diseases
Dr. C. Wang (PI)
Jeffery Rubinoff Foundation
Flowcytometry cells sorter facility and hematopoietic
$41,200
$250,000
stem cell banking
Dr. C. Wang
Dr. Warren Chan (PI)
Research
Dr. E. Winsor (PI)
Canadian Foundation for
Dr. D. Chitayat
Innovation
Quantum dot-based biomolecular imaging
$300,000
Canadian Molecular Genetic Platform
$60,000
TOTAL - 2005-2006
$7,826,723
TOTAL GRANTS 2005-2006
$31,770,404
Dr. K. Pritzker
16 investigators
PRESENTATIONS & ABSTRACTS
July 1, 2005 – June 30, 2006
Dr. Irene Andrulis
Trudeau, M.E., Pritchard, K.I., Chapman, J-A, Hanna, W.M., Kahn ,H.J., Murray, D., Sawka, C.A., Mobbs, B.G.,
Andrulis, I.L., McCready, D.R., and Lickley, H.L. (2005) Prognostic Factors Affecting the Natural History of NodeNegative Breast Cancer. Breast Cancer Research Treatment 89: 35-45.
Bane, A.L., Tjan, S., Parkes, R., Andrulis, I.L., and O’Malley. F.P. (2005) Invasive Lobular Carcinoma: to grade or not
to grade. Mod Path 18: 621-628.
Wunder, J.S., Gokgoz, N., Parkes, R., Bull, S.B., Eskandarian, S., Davis, A.M., Beauchamp, C.P., Conrad, E.U.,
Grimer, R.J., Healey, J.H., Malkin, D., Mangham, D.C., Rock, M.J., Bel, R.S., and Andrulis, I.L. (2005) TP53
Mutations and Outcome in Osteosarcoma: A Prospective, Multicenter Study. J Clin. Oncol. 23:1483-1490.
Eppert, K., Kandel, R., Aneliunas, V., Wunder, J.S., and Andrulis, I.L. (2005) Von Willebrand Factor Expression in
Osteosarcoma Metastasis. Mod Path 18: 388-397.
Milne, R.L., Knight, J.A., John, E.M., Dite, G.S., Balbuena, R., Ziogas, A., Andrulis, I.L., West, D.W., Southey M.C.,
Giles, G.G., McCredie, M.R.E., Hopper, H.L., Whittemore, A.S., for the Breast Cancer Family Registry. (2005) Oral
contraceptive use and risk of early-onset breast cancer in carriers and non-carriers of BRCA1 and BRCA2 mutations.
Cancer Epidemiol Biomarkers Prev 14:350-356.
Eppert, K., Wunder, J.S., Aneliunas, V., Tsui, L-C., Scherer, S.W., and Andrulis, I.L. (2005) Altered expression and
deletion of RMO1 in osteosarcoma. Int J Cancer 114: 738-746.
To, M.D., Faseruk, S.A., Gokgoz, N., Pinnaduwage, D. Done, S.J., and Andrulis, I.L. (2005) LAF-4 is Aberrantly
Expressed in Human Breast Cancer. Int J Cancer 115: 568-574.
Mastracci, T.L., Tjan, S., O’Malley, F.P., and Andrulis, I.L. (2005) E-cadherin alterations in atypical lobular hyperplasia
and lobular carcinoma in situ Mod Path 18:741-51.
Sauer, M. and Andrulis, I.L. (2005) Identification and characterization of missense alterations in the BRCA1associated RING domain (BARD1) gene in breast and ovarian cancers. J of Med Genet. 42: 633-638.
He, W., Bull, S.B., Gokgoz, N., Andrulis, I.L, and Wunder, J. (2006) Application of reliability coefficients in cDNA
microarray data analysis. Statist. Med. 25:1051-1066.
Knight, J.A., John, E.M., Milne, R.L., Dite, G.S., Balbuena, R., Shi, E.J.Q., Giles, G.G., Ziogas, A., Andrulis, I.L.,
Whittemore, A.S., Hopper, J.L. for the Breast Cancer Family Registry. (2006) An inverse association between ovarian
cysts and breast cancer. Int J Cancer 118: 197-202.
| 33
Tiet, T.D., Hopyan, S., Nadesan, P., Gokgoz, N., Poon, R., Andrulis, I.L., Alman, B.A., and Wunder, J.S. (2006)
Constitutive hedgehog signalling in chondrosarcoma upregulates tumor cell proliferation. Amer. J. Pathol. 168:321330.
Spurdle, A.B., Antoniou, A.C., Kelemen, L., Holland H., Peock, S., Cook, M.R., Smith, P.L. Greene, M.H., Simard, J.,
Plourde, M., Southey, M., Godwin, A., Beck, J., Miron, A., Daly, M., Santella, R., Hopper, J., John, E.M., Andrulis,
I.L., Durocher, F., Struewing, J.P., ABCFS, AJBCS, BCFR, INHERIT, kConFaB, EMBRACE Study Collaborators, Easton,
D.F., and Chenevix-Trench, G. (2006) The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1
and BRCA2 mutation carriers. Cancer Epidemiol, Biomarkers and Prev.15:76-79.
Bernstein, J.L., Teraoka, S.N., John, E.M., Andrulis, I.L., Knight, J., Lapinski, R., Olson, E.R., Wolitzer, A.L., Seminara.
D., Whittemore, A.S., and Concannon, P. (2006) The CHEK2*1100delC germline mutation and risk of breast cancer.
Cancer Epidemiol, Biomarkers and Prev. 15:348-352.
To, M.D., Gokgoz, N., Doyle, T.G., Donoviel, D., Knight, J.A., St. George Hyslop, P., Bernstein, A. and Andrulis, I.L.
(2006) Functional Characterization of Novel Presenilin-2 Variants Identified in Human Breast Cancers. Oncogene
25:3557-3564.
Smith, P., McGuffog, L., Easton, D.F., Mann, G.J., Pupo, G.M., Newman, B., Chenevix-Trench, G., kConFab
Szabo, C., Southey, M., Renard, H., Odefrey, F., Lynch, H., Stoppa-Lyonnet, D., Couch, F., Hopper, J.L., Buys, S.,
Andrulis, I.L., Senie, R., Breast Cancer Family Registry, BRCAX Collaborators group, Goldgar, D.E., Oldenburg, R.,
Kroeze-Jansema, K., Kraan, J., Meijers-Heijboer, H., Klijn, J.G.M., van Asperen, C., van Leeuwen, I., Vasen, H.F.A.,
Cornelisse, C.J., Devilee, P., Baskcomb, L., Seal, S., Barfoot, R., Mangion, J., Hall, A., Edkins, S., Rapley, E., Wooster,
R., Chang-Claude, J., Eccles, D., Evans, D.G., Futreal, P.A., Nathanson, K.L., Weber, B.L., Breast Cancer Susceptibility
Collaboration (UK), Rahman, N., Stratton, M.R. (2006) A genome wide linkage search for breast cancer susceptibility
genes. Genes, Chromosomes and Cancer 45: 646-655.
Pritchard K.I., Shepherd L.E., O’Malley F.P., Andrulis I.L., Tu D., and Levine M.N. for the National Cancer Institute
of Canada Clinical Trials Group. (2006) Neu/ErbB2 and responsiveness of breast cancer to adjuvant chemotherapy.
New England Journal of Medicine 354:2103-2111.
Barsyte-Lovejoy, D., Lau, S.K., Boutros, P.C., Khosravi, F., Jurisica, I., Andrulis, I.L., Tsao, M.S., and Penn, L.Z. (2006)
The c-Myc oncogene directly induces H19 non-coding RNA by allele specific binding to potentiate tumorigenesis.
Cancer Research 66:5330-5337.
Onay, V.U., Briollais, L., Knight, J.A., Shi, E., Wang, Y., Wells, S., Li, H., Rajendram, I., Andrulis, I.L., and Ozcelik, H.
(2006) SNP-SNP Interactions in Breast Cancer Susceptibility. BMC Cancer. 6:114.
Yan, T., Wunder, J.S., Gokgoz, N., Seto, K., Bell, R.S. and Andrulis, I.L. (2006) hCDC4 variation in osteosarcoma.
Cancer Genetics and Cytogenetics 169:138-142.
McGuire, V., John, E.M., Felberg, A., Haile, R.W., Boyd, N.F., Thomas, D.C., Jenkins, M.A., Milne, R.L., Daly, M.B.,
Ward, J., Terry, M.B., Andrulis, I.L., Knight, J.A., Godwin, A.K., Giles, G.G., kConFab Investigators, Southey, M.,
West, D.W., Hopper, J.L., Whittemore, A.S. (2006) No increased risk of breast cancer associated with alcohol
consumption among carriers of BRCA1 and BRCA2 mutations under age 50 years. Cancer Epidemiol, Biomarkers
and Prev 15:1565-1567.
Mastracci, T.L., Shadeo, A., Colby, S.M., Tuck, A.B., O’Malley, F.P., Bull, S.B., Lam, W.L., and Andrulis, I.L. (2006)
Genomic alterations in lobular neoplasia: CGH-microarray signature for neoplastic proliferation in the breast.
Genes, Chromosomes and Cancer 45:1007-1017.
Haile, R.W., Thomas, D.C., McGuire, V., Felberg, A., John, E.M., Milne, R.L., Hopper, J.L., Jenkins, M.A., Levine, A.J.,
Daly, M.M., Buys, S.S., Senie, R.T., Andrulis, I.L., Knight, J.A., Godwin, A.K., Southey, M., McCredie, M.R.E., Giles,
G.G., Andrews, L., Tucker, K., Miron, A., Apicella, C., Tesoriero, A., Bane, A., Pike, M.C., kConFab Investigators,
Ontario Cancer Genetics Network Investigators, and Whittemore, A.S. (2006) BRCA1 and BRCA2 mutation carriers,
oral contraceptive use and breast cancer before age 50. Cancer Epidemiol, Biomarkers and Prev.15:1863-1870.
Bernstein, J.L., Seminara. D., John, E.M., Chenevix-Trench, G., Hopper, J., Lapinski, R.H., Andrulis, I.L., Knight, J.,
Whittemore, A.S., West, D.W., Teraoka, S., Wallis, A. and Concannon, P. (2006) T7271G and IVS10-6T ATM gene
mutations in a population-based family registry of breast cancer. Human Mutation. 27:1122-1128.
Dr. Bharati Bapat
Buongiorno, P., Pethe, V., Esufali, S., Bapat, B. Rac1 GTPase associates with beta-catenin/TCF transcription factor
complex to modulate Wnt target gene activation. Keystone Symposium Meeting, “Wnt and beta-catenin signalling
in development and disease” Snowbird, Utah, April 2006.
Perera, S., Bapat, B. The role of mismatch repair gene variants in HNPCC susceptibility. 97th Annual Meeting of the
American Association for Cancer Research, Washington DC, April 2006.
Mrkonjic, M., Raptis, R., Pethe, V., Knight, J.A., Monga, N., Daftary, D., Younghusband, B., Parfrey, P., Gallinger, S.
Green, R., McLaughlin, J., Bapat, B. Association of MLH1 and MSH2 promoter polymorphisms and colorectal cancer
risk. 97th Annual Meeting of the American Association for Cancer Research, Washington DC, April 2006.
Perera, S., Bapat, B. Functional analysis of inherited genetic variants associated with hereditary colorectal cancer
predisposition. 55th Annual Meeting of the American Society of Human Genetics, Salt Lake City, Utah, October
2005.
Mrkonjic, M., Raptis, R., Knight, J.A., Pethe, V., Monga, N., Daftary, D., Younghusband, B., Parfrey, P., Gallinger, S.
Green, R., McLaughlin, J., Bapat, B. Association of MLH1 and MSH2 promoter polymorphisms and colorectal cancer
risk: A population-based case-control study of Canadian CRC cases. 55th Annual Meeting of the American Society
of Human Genetics, Salt Lake City, Utah, October 2005.
Charames, G, Bapat, B. COX-2 mediated inhibition of apoptosis in colon cancer. 96th Annual Meeting of the
American Association for Cancer Research, Anaheim, CA, April 2005.
Dr. Terry Colgan
Siu KWM, DeSouza LV, Dube V, Ghanny S, Guo J, Grigull J, Romaschin AD, Colgan TJ. Novel aspect: Validation
of our previously discovered and identified endometrial cancer biomarkers by iTRAQ methodology on 40 samples
and antigen/antibody recognition in tissue microarray format on 148 samples. International Mass Spectrometry
Conference in Prague, 2006.
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Invited speaker: A Canadian tale of tissue proteomics. Presented at the Ontario Association of Pathologists 67th
Meeting, Deerhurst, Ontario, May 2005.
Invited speaker: Liquid based cytology. Cervical Screening Day of McMaster University, Royal Botanical Gardens,
Burlington, Ontario, May 2005.
Invited speaker: Implications of Implementing Revised Guidelines: Impact on Laboratories, the Ontario Cervical
Screening Program (Cancer Care Ontario) on Implementing Revised Cervical Screening Guidelines, Royal York Hotel,
Toronto, September 2005.
Opening address: Looking into the Crystal Ball, the Screening Lab in 2010. National Meeting of Provincial Cervical
Screening Programmes, sponsored by Cancer Care Ontario, Queen’s Park, Toronto, September 2005.
Workshop participant: NCIC CTG Proteomics Retreat. National Cancer Institute of Canada, Toronto, Ontario, April
2006.
Invited speaker with Fernandes B.: Implementation, Workload Analysis and Next Steps in Laboratory Medicine.
Ontario Association of Pathologists 68th Meeting, Collingwood, Ontario, June 2006.
Invited debater: Be it finally resolved that LBC has a role in cervical cancer screening. Society of Canadian
Colposcopists, 20th Annual Meeting, Vancouver, June 2006.
Dr. Greg Denomme
Branch DR, Shabani F, Denomme GA. Increased TGF� and PGE2 Production Characterizes Cytokine Production
Following Rh Immune Globulin Prophylaxis. Transfusion Medicine 15:347-348, 2005.
Pendergrast J, Denomme GA. Requests for phenotyped red blood cells received by Canadian Blood Services,
Toronto Regional Office. Transfusion Medicine 15:355-356, 2005.
Blackall DP, Oza KK, Arndt PA, Garratty G, Denomme GA. Hemolytic disease of the newborn due to anti-Ge3:
combined antibody-dependent hemolysis and erythroid precursor inhibition. Transfusion 45(3S):6A, 2005.
Judd J, Dake LR, Denomme GA. Confounding serological and molecular data in the investigation of Rh typing
discrepancies. Transfusion 45(3S):130A, 2005
Su B, Chan HHW, Branch DR, Denomme GA. IVIG down-regulates LPS-induced TNF� production via inhibition of I�B�
activation: a possible mechanism of action in the treatment of bacterial infections. American Society of Hematology,
Annual Meeting, New Orleans, LA. Blood 106 (Part 1):628a, 2005.
Chan HHW, Su B, Li W, Kelton JG, Denomme GA. Intravenous immunoglobulin does not increase RNA expression of
Fc�RIIb in purified monocytes. American Society of Hematology, Annual Meeting, New Orleans, LA. Blood 106 (Part
2):52b, 2005.
Hemolytic disease of the newborn due to anti-Ge3: combined antibody-dependent hemolysis and erythroid
precursor inhibition. American Association of Blood Banks Annual Meeting, Seattle, WA, October 17, 2005
(Abstract published - Transfusion 45 (3S):6A, 2005.
Inhibition of erythroid progenitor cell growth by antibodies against determinants on glycophorin C. American
Association of Blood Banks Annual Meeting, Seattle, WA, October 18, 2005 (Abstract published - Transfusion 45
(3S):28A, 2005)
Distribution of microdeletions in DAZ (Deleted in Azoospermia) family genes located on Y-chromosome AZF region
(Azoospermic Factor) in patients with infertility. American Society for Reproductive Medicine and the Canadian
Fertility and Andrology Society, Montreal, PQ, October 2005
The mechanism of Rh-immune globulin prophylaxis involves significant increases in the immunosuppressive
cytokines TGF� and PGE2. American Society for Hematology, Annual Meeting, Atlanta GA, (Abstract published
- Blood 106 (Part 1):154, 2005), December 2005.
Invited Speaker: Practical Applications of Molecular Testing for Blood Groups - When and Why. SSCC Education
Session, American Association of Blood Banks, Annual Meeting, Seattle, WA, October 2005.
Invited Speaker: RHD DNA Diagnostics ¬– Where are we now? Transfusion Safety and New Technologies,
Shenzhen Blood Center, Shenzhen, P.R.China, November 2005.
Invited Speaker: Intrauterine Transfusion. Lunch ‘n’ Learn, McMaster University Medical Centre, September 2005.
Invited Speaker: The Effect of Anti-Kell on Erythropoiesis, Vascular Biology Research Group, McMaster University,
Hamilton, ON, November 2005.
Dr. Eleftherios Diamandis
Oikonomopoulou K, Hansen K, Saifeddine M, Diamandis EP, Hollenberg MD. Cell signaling via proteinase-activated
receptors (PARS): A new role for kallikreins. 4th Gen Meet Intl Proteolysis Soc 2005;79, #PI 6.
Komatsu N, Suga Y, Saijoh K, Liu AC, Khan S, Mizuno Y, Ikeda S, Jayakumar A, Clayman GL, Shirasaki F, Takehara
K, Diamandis EP. Elevated Human Tissue Kallikrein Levels in the Stratum Corneum and Serum of Peeling Skin
Syndrome-Type B Patients Suggests an Over-Desquamation of Corneocytes. 67th Society for Invest Dermatol 2006;
#348.
Paliouras M, Diamandis EP. Coordinated hormone regulation of multiple kallikreins in breast cancer cell lines. Proc
AACR 2006; #91.
White NMA, Yousef GM, Diamandis EP, Doré JJ. The human kallikrein gene 6 (KLK6) in combination with CA125 is
a more sensitive marker for ovarian cancer than CA125 alone. Proc AACR 2006; #94
Shan SJC, Katsaros K, Paliouras M, Rigault I, Puopolo M, Diamandis EP. Up-regulation of human tissue kallikrein 6 in
ovarian carcinoma. Proc AACR 2006; #102.
| 37
Paliouras M, Diamandis EP. Investigating the role of intracellular signaling pathways in regulating kallikrein
expression. Proc AACR 2006; #1655.
Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diamandis EP,
Hollenberg MD. Kallikrein 14 signaling through proteinase-activated receptors. Proc AACR 2006; #1686.
Memari M, Diamandis EP, Van der Kwast T. Immunohistochemical localization and expression profiling of human
kallikrein 12 in human prostate cancer tissues. Proc AACR 2006; #1980.
Shaw JL, Grass L, Soosaipillai A, Sotiropoulou G, Diamandis EP. Development of an immunoassay for human
kallikrein 15, a potential prostate and ovarian cancer biomarker. Proc AACR 2006; #1985.
Memari N, Grass L, Karakucuk EI, Shaw JL, Diamandis EP. Protein expression, antibody generation, and development
of a highly sensitive immunoassay for the detection of human tissue kallikrein 9. Proc AACR 2006; #2889.
Sardana G, Marshall J, Diamandis EP. Identification and characterization of novel candidate prostate cancer
biomarkers through proteomic analysis of the secretome of three prostate cancer cell lines. Proc AACR 2006;
#3572.
Petraki C, Papanastasiou PA, Karavana VN, Diamandis EP. Immunohistochemical expression of human tissue
kallikreins in neoplasms of various organs. Proc AACR 2006; #4358.
Emami N, Michael IP, Diamandis EP. Proteolytic cascades of human tissue kallikreins. Proc AACR 2006; #4368.
Oikonomopoulou K, Shannon P, Petraki CD, Diamandis EP. Immunohistochemical localization of kallikrein 6 in brain
tumors. Proc AACR 2006; #4488.
Shan SJC, Scorilas A, Soosaipillai A, Katsaros D, Rigault I, Puopolo M, Diamandis EP. Human tissue kallikrein 7 overexpression in ovarian carcinoma: a novel marker of unfavorable prognosis. Proc AACR 2006; #4503.
Simon I, Diamandis EP, Katsaros D, Kim NW, Wolfert RL. B7-H4 (DD-O110) protein is over-expressed in early-stage
ovarian cancer tumor tissue. Proc AACR 2006; #4505.
Kundig C, Cloutier SM, Aellen S, Felber LM, Chagas JR, Gygi CM, Jichlinski P, Leisinger H-J, Diamandis EP, Deperthes
D. Human kallikrein 2 (hK2) inhibitors suppress tumor growth of prostate cancer xenografts in nude mice. J Urol
(suppl) 2006;175:263, #815.
Heshmat SM, Jarvi K, Mullen B, Diamandis EP, Lo KC. Seminal plasma lipocalin type PGDS: A potential marker for
the diagnosis of obstructive azoospermia. J Urol (Suppl) 2006;175:523, #1623.
Oikonomopoulou K, Hansen K, Saifeddine M, Diamandis EP, Hollenberg MD. Kallikrein signaling in cancer via
proteinase-activated receptors. NIH Proteomics Int Group 2006;#85.
Dr. Bernard Fernandes
Workload Reporting in Laboratory Medicine. Ontario Association of Pathology, Collingwood, ON, June 1-3, 2006.
Dr. Steven Gallinger
The Fifth Princess Margaret Hospital Conference: New Developments in Cancer Management. Keynote Presentation
“Genetic predisposition to gastrointestinal cancer: Progress and frustration”. Toronto, September 2005.
IMS Lecture Series-Critical Care: Bench to Bedside. “Cancer genetics” Toronto General Hospital March 2006.
Cotterchio M, Boucher B, Manno M, Gallinger S. Dietary phytoestrogen intake is associated with reduced colorectal
cancer risk. SER-CSEB Meeting, Toronto, Ontario. June 27-30, 2005 Am J Epidemiol 2005: 161.
Fazio L, Cotterchio M, Manno J, McLaughlin J, Gallinger S. Association between colonic screening subject
characteristics and stage of colorectal cancer. SER-CSEB Meeting, Toronto Ontario. June 27-30, 2005 Am J
Epidemiol 2005: 161.
Tucker A, Cotterchio M, Gallinger S, Kreiger N, McLaughlin J, Koo M. Access to educational colorectal cancer
website and subject participation in the Ontario Familial Colorectal Cancer Registry (OFCCR). SER-CSEB Meeting,
Toronto Ontario. June 27-30, 2005 Am J Epidemiol 2005: 161.
Ramji F, Cotterchio M, Manno M, Rabeneck L, Gallinger S. Association between subject factors and colorectal
cancer screening participation in Ontario Canada. SER-CSEB Meeting, Toronto Ontario. June 27-30, 2005 Am J
Epidemiol 2005: 161.
Dr. Marc Grynpas
3rd International Conference on Children’s Bone Health, Sorrento, Italy. “The use of bone quality parameters in
bone biopsies of children with primary osteoporosis”, May 2005.
Universite Catholique de Louvain, “group de Recherché et d’etude en chirurgie
“Le degree de mineralization de la matrice osseuse”, October 2005.
Orthopedique” Bruxelles,
Universite Catholique de Louvain, “group de Recherché et d’etude en chirurgie Orthopedique” Bruxelles, “ Le
mineral osseux”, October 2005.
Hunt T, Bhola P, Moreno L, Jurisicova A, Grynpas MD. Differences in bone fragility among 5 inbred mice strains.
Pathology Poster Session, University of Toronto, June 2005.
Moreno L, Cheung A and Grynpas MD. The role of creep in the sex differences of long bone resistance to fatigue
failure. XXth Congress of the International Society of Biomechanics and 29th Annual Meeting of the American
Society of Biomechanics, Cleveland, Ohio, USA, July 2005.
Wang SX, Laverty S, Grynpas MD. Quantifying joint changes in an OA model using 3D and 2D imaging techniques.
International Symposium on Quality of Bone and Scaffold Biomaterials Evaluated by microCT, pQCT and MRI, Hong
Kong, October 2005.
Holmes C, Khan TS, Owen C, Grynpas MD, Stanford WL. Characterization of the age-dependent osteoporotic
phenotype in Sca-1/Ly6A null mice. Challenges in Regenerative Medicine (ChaRM), Toronto, October 2005.
| 39
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Diabetic Osteoporotic
Bone Model. SLRI Retreat, YMCA, Geneva Park Conference Centre, Toronto, October 2005.
Holmes C, Khan TS, Owen C, Grynpas MD, Stanford WL. Characterization of age-dependent osteoporotic
phenotype of Stem Cell Antigen-1 Null Mice. Canadian Arthritis Network 2005 Annual Scientific Conference,
Gatineau, Quebec, October 2005.
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Diabetic and Osteoporotic
Bone Model. IBBME Seminar, University of Toronto, December 2005.
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. (2006) The Effects of Vanadium Treatment on Diabetic and
Osteoporotic Bone Model. MSE seminar, University of Toronto, March 2006.
Wise L, Sukhu B, Benito A, Nunez G, Perez G, Tilly J, Jurisicova A, Grynpas MD. Comparison of Bone Quality in
Mice Deficient in Pro-Apoptotic Members of the BCL-2 Gene Family. 23rd European Calcified Tissue Society (ECTS)
Meeting, Prague, Czech Republic, May 2006.
Khan TS, Holmes CM, Grynpas MD and Stanford WL. Characterization of age-dependent osteoporosis in Sca-1/
Ly6A null mice. 23rd European Calcified Tissue Society (ECTS) Meeting, Prague, Czech Republic, May 2006.
Khan TS, Holmes CM, Grynpas MD and Stanford WL. Characterization of the Age-related osteoporotic phenotype
in Sca-1 null mice. 23rd European Calcified Tissue Society (ECTS) Meeting, Prague, Czech Republic, May 2006.
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. Effects of Vanadium Treatment on Bone Qualities on a
Combined Osteoporotic Diabetic Rat Model. Banting and Best Scientific Day, Sunnybrook Health Science Centre,
May 2006.
Combined Osteoporotic Diabetic Rat Model. University of Toronto, Bone and Mineral Group-Research Day, May
2006.
Neufeld S, Rowe E, Milton KR, Carran J, Wainman S, Anastassiades T, Grynpas MD. The Effects of N-butyryl
Glucosamine on Bone Quality in an Ovariectomized Rat Model. University of Toronto, Bone and Mineral GroupResearch Day, May 2006.
Hunt T, Vieth R, Kandel R, Grynpas MD. Can Vitamin D affect the Progession of Osteoarthritis in a Guinea Pig
Model? University of Toronto, Bone and Mineral Group-Research Day, May 2006.
Neufeld S, Rowe E, Milton KR, Carran J, Wainman S, Anastassiades T, Grynpas MD. The Effects of N-butyryl
Glucosamine on Bone Quality in an Ovariectomized Rat Model Canadian Connective Tissue Conference (CCTC),
University of Ottawa, May 2006.
Combined Osteoporotic Diabetic Rat Model. Canadian Connective Tissue Conference (CCTC), Ottawa, May 2006.
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Bone Qualities on a
Combined Osteoporotic and Diabetic Female Rat Model. International Osteoporosis Foundation. (IOF) World
Congress on Osteoporosis, Toronto, June 2006.
Khan TS, Holmes CM, Grynpas MD and Stanford WL. Characterization of the age-dependent osteoporotic
phenotype in the Sca-1/Ly6A null mice. International Osteoporosis Foundation. (IOF) World Congress on
Osteoporosis, Toronto, June 2006.
Khan TS, Holmes CM, Grynpas MD and Stanford WL. Characterization of the Age-related osteoporotic phenotype
in Sca-1-/- mice. International Osteoporosis Foundation. (IOF) World Congress on Osteoporosis, Toronto, June
2006.
Wise L, Sukhu B, Benito A, Nunez G, Perez G, Tilly J, Jurisicova A, Grynpas MD.
(2006) Comparison of Bone Quality in Mice Deficient in Pro-Apoptotic Members of the BCL-2 Gene Family.
International Osteoporosis Foundation. (IOF) World Congress on Osteoporosis, Toronto, June 2006.
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Bone Qualities on a
Combined Osteoporotic and Diabetic Female Rat Model. IBBME Scientific Day, University of Toronto, June 2006.
Holmes C, Khan TS, Grynpas MD, Stanford WL. Characterization of age-dependent osteoporosis in Sca-1/Ly6A null
mice. International Society of Stem Cell Research (ISSCR), Toronto, June 2006.
Dr. Barry Hoffman
Likhodii, S.S., Moller, C. and Hoffman, B. A software tool to facilitate method comparison and bias estimation.
50th Annual Conference of the Canadian Society of Clinical Chemists. Victoria, British Columbia, June 2006.
Li, H., Seiden-Long, I., Bromberg, IL., Hoffman, BR. Three GFR estimation formulae yield similar but frequently
inaccurate predictions of the creatinine clearance. 50th Annual Conference of the Canadian Society of Clinical
Chemists. Victoria, British Columbia, June 2006.
Dr. Rita Kandel
Towards Bioengineering a Scaffold-Free Nucleus Pulposus. ECM VI/SRN I Spinal Motion Segment: From Basic
Science to Clinical Application. Davos Switzerland. July 2005.
Tissue Engineering an Intervertebral Disc Using Silk Scaffold. First Annual TERC Review. Medford, MA. August
2005.
Soft Tissue Challenges. Pathology Update Day, University of Toronto. Toronto, ON. November 2005.
In Vitro Model of Nucleus Pulposus Degeneration. Abbot Webex Presentation. Abbot Park, IL. November 2005.
Current Uses of Stem Cell Therapies in Regenerative Medicine. 2006 Toronto Regenerative Medicine Day. Toronto,
ON. April 2006.
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Tissue Engineering of joint replacement; a new approach. Bone and Mineral Group Research Day, University of
Toronto. Toronto, ON. May 2006.
Resurfacing focal cartilage defects with biphasic implants in a sheep model. Bioengineering for the Restoration of
Joint Function Workshop, Canadian Arthritis Network, Vancouver, British Columbia. June 2006.
Consensus Meeting for Cartilage Repair Grading System. Leuven, Belgium. June 2006.
Kandel R, Li SQ, Werier J, Kauzman A, Ferguson P, Bell R, Wunder J. Abnormalities in Cell Cycle Proteins in Giant
Cell Tumors. 11th Annual CTOS Meeting. Boca Raton, FL, USA. November 2005.
De Croos JNA, Jang B, Grynpas MD, Pilliar RM, Kandel RA. Early Upregulation of EGR-1 and MT1-MMP after Cyclic
Mechanical Compression of In Vitro Grown Chondrocytes. 52st Annual Meeting of the Orthopaedic Research
Society. Chicago, IL. March 2006.
Chang G, Kandel RA, Jin HJ, Vunjak-Novakovic, G, Kaplan D. Annulus Fibrosus Cells Form Tissues when Grown in
Porous Silk Scaffold in a Bioreactor. 52st Annual Meeting of the Orthopaedic Research Society. Chicago, IL. March
2006.
St-Pierre JP, Cruz LC, Grynpas MD, Pilliar RM, Kandel RA. Substrates Affect the Formation of the Calcified Zone in
Articular Cartilage Formed In Vitro. 52st Annual Meeting of the Orthopaedic Research Society. Chicago, IL. March
2006.
Gan L, Tse C, Pilliar RM, Kandel RA. Low-Power Laser Stimulation Improves Cartilaginous Tissue Formation In Vitro.
52st Annual Meeting of the Orthopaedic Research Society. Chicago, IL. March 2006.
Séguin CA, Pilliar RM, Kandel RA. TNF� Stimulated Activation of MMP-2 in Nucleus Pulposus Cells Occurs through
EGR-1 Mediated Transcription of MT1-MMP. 52st Annual Meeting of the Orthopaedic Research Society. Chicago,
IL. March 2006.
White L, Marshall S, Kandel RA, Hurtig M. T2 MRI Mapping for Differentiation of Hyaline Cartilage versus Repair
Tissue after Cartilage Repair Procedures. 52st Annual Meeting of the Orthopaedic Research Society. Chicago, IL.
March 2006.
Hurtig M, Kandel RA, Grynpas M, Pilliar R, Lee J, Waldman S, Zalzal P. Survival and Adaptation of Biphasic
Cartilage-Calcium Polyphosphate Implants in a Sheep Model. 52st Annual Meeting of the Orthopaedic Research
Society. Chicago, IL. March 2006.
Dr. Sarah Keating
Keating, S., Edmondson, N., Bocking, A., Rizek, R., Watson, C., Machin, G. The prevalence of chronic deciduitis in
cases of preterm labour. Society for Pediatric Pathology Atlanta, Georgia, February 2006.
Keating, S., Kingdom, J., Toal, M., Chan, C., Windrim, R., Machin, G. Correlation of placental pathology with
uterine artery Doppler findings in high risk pregnancies. Society for Pediatric Pathology Atlanta, Georgia, February
2006.
Shannon, P., Halliday, W., Viero, S., Keating, S. Spinal cord lesions in intrauterine asphyxia. Society for Pediatric
Pathology Atlanta, Georgia, February 2006.
Viero, S., Whittle, W.L., Shin, V., Keating, S., Kingdom, J. Pathology of echogenic cystic lesions of the placenta:
a study utilizing postdelivery sonographically guided needle localization. Society for Pediatric Pathology Atlanta,
Georgia, February 2006.
Dr. Elena Kolomietz
2006 PLM Genetic rounds, MSH: Array CGH: Expanding resolution of cytogenetic analysis.
2005 PLM Genetic rounds, MSH: Recent advances in X-chromosome inactivation.
2005 Grand rounds presentation, Lakeridge Health Corporation, Oshawa: Recent advances in Xchromosome
inactivation. Prenatal diagnosis of de novo X; autosome translocation.
Prenatal diagnosis of acute promyelocytic leukemia in a fetus at 28 weeks’ gestation. ASHG meeting, Salt Lake City,
2005.
Subtelomeric familial translocation t(8;12)(p23.1;p13.1) leading to deletion 8pter-p23.1 and duplication 12pterp13.1: molecular cytogenetic analysis and clinical phenotype in two siblings. ASHG meeting, Salt Lake City, 2005.
Dr. Iona Leong
Crescent Oral Surgery sponsored seminar ‘Common Lesions of the Oral Mucosa November 2005.
Halton-Peel Dental Association invited speaker, lecture ‘Common Oral Mucosal Lesions’ May 2006.
| 43
Expression of Caspase-3, Survivin, and Bcl-2 in Adenoid Cystic Carcinoma using Tissue Microarray Technology.
Makino A., MacMillan C., Perez-Ordonez B. Modern Pathology. Poster Session Head and Neck, Poster Board #94,
Feb 28/05, United States and Canadian Academy of Pathology Annual Meeting, San Antonio 2005.
A. Zhou, PP Reis, MA Sukhai, J Freeman, C MacMillan, S Kamel-Reid BRAF and ret/ptc alterations in Hurthle cell
tumors of the thyroid. Poster at Summer
Student Research Day, Department of Pathobiology and Laboratory Medicine, University of Toronto, August 2005.
Dr. David Mock
University of Western Ontario, Faculty of Medicine & Dentistry, “ Economics of
Canadian Schools of Dentistry”, London, Ontario, 2005
Canadian Dental Association, “Ensuring a Sustainable Future for Academic Dentistry in
Canada”, Ottawa Ontario, 2005
P.G. Anderson Study Club, “The TMD Delemma”, Toronto, Ontario, 2006.
Ontario Medical Association, Section on Physical Medicine & Rehabilitation, “PostTraumatic Temporomandibular Disorders”, Toronto, Ontario, 2006.
“ A new role for histopathology in breast cancer: BRCA risk stratification.” Pathology Update CME symposium,
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, November 2005.
“HER2/neu as a predictor of response to anthracycline based chemotherapy: data from
the MA5 NCIC clinical trial. University of Toronto Breast Cancer Symposium, Toronto, November 2005.
Co-Chair, Eastern Canada Consultants Workshop on HER2 testing, Toronto, November 2005.
Co-Moderator, proffered papers, breast pathology section, United States and Canadian Academy of Pathologists
meeting Atlanta, February 2006.
Royal College of Surgeons and Physicians of Canada sponsored speaker: OAP slide seminar in breast pathology,
June 2006.
Co-Chair, Eastern Canada Consultants Follow-up Workshop on HER2 testing, Toronto, June 2006.
Chapman JW, Jasani B, Ibrahim M, Miller K, Murray D, Hewlett B, Daidone MG, Allred C, Hammond E, Li D, Sweep
F, O’Malley FP, Kelly J, Goss P. Standardization of estrogen and progesterone receptor assay values. Breast Cancer
Research and Treatment 2005; 94(S1):S242. Abstract #5101.
AL Bane, S Tjan, N Weerasooriya, IL Andrulis, FP O’Malley. BRCA2 associated breast cancers exhibit a luminal
phenotype despite their high histologic grade. United states and Canadian Academy of Pathologists meeting,
Atlanta, February 13, 2006. Mod Pathol; 83, 21A, 2006.
A.M. Chiarelli, V. Majpruz, R. Shumak, F.P. O’Malley, V. Mai. The contribution of clinical breast examination on
prognostic measures of effectiveness in a breast screening program. Presented at CBCRA, Reasons for Hope, 4th
Scientific Conference, Montreal, May 6-8, 2006 and International Breast Cancer Screening Network (ISBN) Biennial
Meeting, Ottawa, May 2006.
A.M. Chiarelli, N. Malek, G. Glendon, P.G. Ritvo, J.A. Knight, V. Kirsh, F.P. O’Malley, I.L. Andrulis. Screening
behaviours and outcomes among relatives of women with breast cancer. Presented at CBCRA, Reasons for Hope,
4th Scientific Conference, Montreal, May, 2006.
F.P. O’Malley, T. Thomson, J. Julian, C. Have, R. Cosby, K. Gelmon, I. Andrulis, T. Whelan for Project 4, Stream of
Excellence Program: Molecular Changes in Breast Cancer Accuracy of HER2/neu Testing in a Population Based
Study of Patients Treated with Trastuzumab. Presented at CBCRA, Reasons for Hope, 4th Scientific Conference,
Montreal, May 2006.
V.A. Kirsh, A.M. Chiarelli, F.P. O’Malley, R.S. Shumak, N.F. Boyd. Tumour characteristics associated with detection of
breast cancer. Presented at CBCRA, Reasons for Hope, 4th Scientific Conference, Montreal, May, 2006.
S. Chia, D.G. Huntsman, F.P. O’Malley, D. Tu, L.E. Shepherd, M.N. Levine, V.H. Bramwell, I.L. Andrulis, K.I. Pritchard.
Prognostic and Predictive Significance of HER-2 in a Randomized Trial Comparing CEF to CMF in Pre-menopausal
Node Positive Breast Cancer (NCIC CTG MA.5 Trial). Presented at CBCRA, Reasons for Hope, 4th Scientific
Conference, Montreal, May 2006.
Dr. Hilmi Özçelik
Invited Speaker. Queens University, Cancer Center” SNPs, protein function and breast cancer predisposition”,
Kingston, Ontario, May 2005.
Invited Speaker. International Medical Care & Diagnostic Conference & Exhibition. “Genetic variation, protein
function and predisposition to breast cancer”, Dubai, United Arab Emirates, September 2005.
Invited working group member and presenter: Familial Breast Cancer Registry, Gene Discovery and Polymorphism
Working Groups, San Francisco CA, November 2005.
Invited working group member and presenter: Familial Breast Cancer Registry, Gene
Discovery and Polymorphism Working Groups, New York NY, April 2006.
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Dr. Aaron Pollett
A Pollett, J McLaughlin, E. Hollowaty, K Leonard. Pathology Reporting to the Ontario Cancer Registry 1996 – 2003:
Evaluating the impact of Rapid Case Ascertainment. Poster presentation, CrCIHRt Annual General Meeting,
Toronto, 2005.
A. Gupta, R. Haddad, J. Bacani, C. O’Brien, A. Pollett, S. Gallinger and C. Swallow. Inadequate lymph node retrieval
(LNR) for gastric cancer across the Province of Ontario and at a tertiary care cancer center. Platform presentation,
Canadian Society of Surgical Oncology, Montreal, 2005.
Invited lecture: Colorectal carcinoma – indications for microsatellite instability (MSI) testing, Pathology Update 2005,
Toronto, November 2005.
Hauck TS, Padmawar PA, Canteenwala T, Pritzker KPH, Chiang LY: Characterization of chemically grafted carbon
nanotubes by EELS spectroscopy. Photonics North, Toronto, Canada, September 2005.
So G, Karotki A, Verma S, Hauck TS, Wilson B, Pritzker KPH, Chiang L: Singlet oxygen production by amphiphilic
C60 derivatives and its correlation to cell cytotoxicity in vitro. Photonics North, Toronto, Canada, September 2005.
Pritzker KPH: OARSI Osteoarthritis Cartilage Pathology Grading System: Development and
International Skeletal Society, Singapore, September 2005.
Implementation.
Chiang L, Pritzker KPH, Wilson B: Two-photon absorption approach toward
biophotonicapplication of
amphiphilic fullerene-fluorene adducts. Symposium “Fullerenes and Carbon Nanotube Based Materials in Medicine
and Biology” of the 209th Meeting of The Electrochemical Society, Adams Mark Denver Hotel, Denver, Colorado,
May 2006.
Pritzker KPH: Why animal models of osteoarthritis? CAN, International Conference on Preclinical Models of
Osteoarthritis, Montreal, May 2006.
Pritzker KPH: Nonhuman primate models of osteoarthritis. CAN, International Conference on Preclinical Models of
Osteoarthritis, Montreal, May 2006.
Las Heras F, Inman RD, Tsui F, Pritzker KPH: Chondrocyte morphology supports ank mice as an animal model
for osteoarthritis (poster presentation). CAN, International Conference on Preclinical Models of Osteoarthritis,
Montreal, May 2006.
Dr. Robert Riddell
CAP Meeting, Victoria, BC. Diagnostic problems in Inflammatory Bowel Disease,
June 2005.
IAP 2005 Congress Meeting, Beijing China. Dysplasia in the GI Tract, August 2005.
The Banff Pathology Course. Pits in the diagnosis of IBD, Barrett’s esophagus dysplasia, Gastritis, Gastric Neoplasia
and Endoscopic Mucosal Resection, September, 2005.
World Congress of Gastroenterology 2005. Toward and integrated clinical, molecular and serological
classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of
Gastroenterology, September 2005.
Path Update 2005. University of Toronto Conference Centre. Gastrointestinal Stromal Tumors (GISTs): A histology
or molecular diagnosis? November 2005.
Digestive Diseases for Physicians and Surgeons. Update on Inflammatory Bowel Disease, “An Update on dysplasia
in IBD, November 2005.
Repubblic Italiana. In nome della Legge, noi, Prof. Dott. Pasquale Mistretta, Rettore dell’Universitá di Cagliari. Prof.
Robert Henry Riddell, Laurea honoris causa in Medicina a Chirurgia.Il presente diploma di laurea viene rilasciato a
tutti gli effetti di legge. Dato in Calgiari, addi 1/12/1005, December, 2005.
The USCAP 95th Annual meeting. The Role of the Histopatholgist in Detection of Adult Hereditary Carcinoma,
Colgan TJ, O’Malley FP, Riddell RH, Atlanta, Georgia, February 2006
IOIBD (International Organization for the Study of inflammatory Bowel Disease).
colitis, Bakubung, South Africa, March 2006.
Pathology of indeterminant
American Society for Clinical Pathology, Surgical Pathology of the GI Tract, Pathology of Inflammatory Bowel
Disease, Unknown and problem cases, South Carolina, April 2006.
Digestive Disease Week. Poster Session: Targeted Esophageal Biopsies: What you see is what you get.
(WYSIWY`G) – Or Not? Post-Grad Course: Dysplasia in Barrett’s Esophagus. Can we do better? Los Angeles,
California, May 2006.
RS, Sandler RS, Bolognese J, Quan H, Oxenius B, Joseph R, Horgan K, Riddell R, Morton D, Lana A, Baron J. A
Randomized Trial of Rofecoxib to prevent colorectal adenomas: the approve trial. Gastroenterology, April 2005 Vol.
128, No. 4, Suppl 2,
Pg. A-34 No:200.
Johnson P, MacNeill N, Baladjay L, Cohen Z, Riddell R, Steinhart H, McLeod R. Early Post-Operative Pouch histology
predicts future chronic pouchitis after ileal Pouch-anal anastomosis for ulcerative colitis.
Gastroenterology,
April 2005, Vol. 128, No.4., Suppl 2. Pg. A-114, No: 734.
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Lanas A, Bresalier R, Sandler R, Bolognese J, Quan H, Oxenius B, Horgan K, Riddell R, Morton D, Baron J. Upper
gastrointestinal events associated with rofecoxib in a colorectal adenoma. Chemoprevention trial. Gastroenterology
2005 Jul;129(1):371.
Padol IT, Sagar M, Riddell RH, Hunt RH. Long term Helicobacter pylori infection of
outbred North American Mongolian gerbils in conjunction with high salt diet does not
result in gastric cancer – revisiting the model. Helicobacter, Vol.10, Issue 5, Pg 505, Abstract #07.02.
Riddell RH, Mann V, Moayyedi P, Veldhuyzen S, Jankowski J, Bardette M, Louw J, Noad G, White RJ, Armstrong D.
Targeted Esophageal Biopsies: What you see is what you get (WYSIWYG). Gastroenterology 2006, Vol 130. Suppl
2. A-161. Abstract
Chen Shawn C, Mouchli A, Chadalawada V, Riddell R, Goldblum J, O’Brien M,
Cummings O.W., Ulbright T. M., Rex D.K. Histopathology of small polyps removed in the videoendoscopic era.
Gastrointestinal Endoscopy 2006 , Vol 63:5. Abstract T1344.
Dr. Patrick Shannon
A Case of Proptosis. JH Oestreicher, MD; NK Pang, MD; D Howarth, MD; P Shannon, MD. Canadian Ophthalmic
Pathology Society, 2006.
Imaging of white matter abnormalities in cortical malformations using diffusion tensor imaging E Widjaja, S Blaser P
Shannon, C Raybaud Radiological Society of North America, 2006.
Immunohistochemical localization of kallikrein 6 in brain tumors K Oikonomopoulou,
P Shannon, E Diamandis AACR Annual Washington, DC, 2006.
Spectrum of CNS Pathology with Fetal Ventriculomegaly Evaluated by MRI Mann, E. H.Blaser, S.Pantazi, S. Shannon,
P. Chitayat, D. Toi, A. Ryan, G. •Raybaud, C., 2006.
Spinal Cord Lesions In Intrauterine Asphyxia P Shannon, W Halliday, S Viero, S Keating. Society for Pediatric
Pathology, Atlanta, 2006.
Histologic variation in cortical ependymomas. M Boulton M Bernstein P Shannon Canadian Association of
Neuropathologists, St John’s, Newfoundland, 2006.
Pathology Update 2005, Toronto. “Avoiding the false positive and negative prostate needle biopsy”, 2005.
European Society of Pathology, Short Course: Prognostic Factors in Uropathology: Prognostic factors and reporting
of prostate carcinoma in radical prostatectomy specimens, invited lecture.
Jahrestagung Basel, November 2005. “Lessons from the european psa screening study erspc for the pathologist”.
Workshop: Over diagnosis of cancer, Florence, November 2005. “Pathology of prostate cancer: evidence for more
and less aggressive lesions”.
Dr. Sandra Viero
Kingdom J, Chaddha V, Alkazaleh F, Keating S, Viero S, Windrim R. From morphology to clinics: imaging placental
insufficiency. Plenary lecture. European Placenta Group Meeting, Glasgow, Scotland, (abstracted in Placenta 26(89)A6:L19), September 2005.
Whittle WL, Viero S, Kingdom J. Needle-wire targeted correlation of placental ultrasound findings with pathological
lesions and obstetrical outcome. New investigators oral presentation. European Placenta Group Meeting, Glasgow,
Scotland, (abstracted in Placenta 26(8-9)A10:O11, 2005), September 2005.
Hawkins C and Viero S. Lissencephaly with cerebellar hypoplasia: A new subtype? Podium presentation, Canadian
Association of Neuropathology Meeting St. John’s, Newfoundland, (abstracted in Can J Neurol Sci; 32: 555, 2005),
September 2005.
Viero S, Whittle WL, Shin V, Keating S, Kingdom J. Pathology of echogenic cystic lesions of the placenta: A
study utilizing postdelivery sonographically guided needle localization. Poster presentation, Society for Pediatric
Pathology, Atlanta, Georgia, February 2006.
Shannon P, Halliday W, Viero S, Keating S. Spinal cord lesions in intrauterine asphyxia.
Podium presentation, Society for Pediatric Pathology, Atlanta, Georgia, February 2006.
Dr. Reinhold Vieth
13th Vitamin D Workshop, Victoria, British Columbia, Canada. Invited Speaker, plus coauthor on two abstracts
promoted to oral sessions. April 7 to 12, 2006.
13th Vitamin D Workshop, Victoria, British Columbia, Canada. Member of organizing committee. April 7 2006.
House of Commons, London England, Meeting on Sunlight, Vitamin D and Health; organized by Health Research
Forum, and sponsored by Ian Gibson MP, in the Atlee Room, Portcullis House, November 2005.
International Workshop on UV Exposure Guidance, Munich, Germany, Joint meeting with WHO and Euroskin,: Sunprotection guidelines, implications with vitamin D. October 2005.
Direct-MS. Invited speaker: The biology of vitamin D, and its implications for the health of Canadians. Calgary
Alberta. Two presentations. October 2005. Council for Responsible Nutrition. Annual meeting, Palm Springs
CA, USA. Invited speaker, “Calcium, Vitamin D and Health”. September 2005.
Italian Endocrine Society. The endocrinology and nutrition of vitamin D. Invited speaker, Lecture for continuing
education. Rome, Italy, July 2005.
British Columbia Dietitians and Health Professionals, June 26, 2006. Vancouver BC
Canadian Cancer Society: North American Conference on UV, Vitamin D and Health. Metropolitan Hotel, Toronto,
March 2006,
Direct-MS, Calgary. Presentation to health professionals in Calgary, Alberta. October 2005. Prospects For Vitamin
D Nutrition For Disease Prevention And Treatment.
| 49
Direct-MS, Calgary. Health information presentation to the general public. An advertised lecture, in Calgary,
Alberta. October 2005. Health Prospects For Vitamin D Nutrition. Recorded and available as a Webcast
http://www.direct-ms.org/presentations.html
Quebec Society of Medical Biochemists. Mont Saint Hiliard, Quebec, October 2005.
Grand Rounds, St Joseph’s Hospital Toronto, “Vitamin D, Victorian vitamine or orphan drug”April 2006.
Grand Rounds, North York General Hospital, “Vitamin D, Victorian vitamine or orphan drug”April 2006.
Scarborough Osteoporosis Support Group. Vitamin D and osteoporosis. Invited Lecture to the public, Scarborough
Village Recreation Center, April 2006.
Dr. Elizabeth Winsor
Kolomietz EK, Winsor EJT, Ryan G, Seaward G, Keating S, Wang C, Chitayat D. Prenatal diagnosis of acute
promyelocytic leukemia in a fetus at 28 weeks’ gestation. Poster, Amer Soc Hum Genetics, October 2005.
SCIENTIFIC PAPERS July 1, 2005 – June 30, 2006
Dr. Irene Andrulis
Sauer, M. and Andrulis, I.L. Identification and characterization of missense alterations in the BRCA1-associated
RING domain (BARD1) gene in breast and ovarian cancers. J of Med Genet. 42: 633-638, 2005.
He, W., Bull, S.B., Gokgoz, N., Andrulis, I.L, and Wunder, J. Application of reliability coefficients in cDNA microarray
data analysis. Statist. Med. 25:1051-1066, 2006.
Knight, J.A., John, E.M., Milne, R.L., Dite, G.S., Balbuena, R., Shi, E.J.Q., Giles, G.G., Ziogas, A., Andrulis, I.L.,
Whittemore, A.S., Hopper, J.L. for the Breast Cancer Family Registry. An inverse association between ovarian cysts
and breast cancer. Int J Cancer 118: 197-202, 2006.
Tiet, T.D., Hopyan, S., Nadesan, P., Gokgoz, N., Poon, R., Andrulis, I.L., Alman, B.A., and Wunder, J.S. Constitutive
hedgehog signalling in chondrosarcoma upregulates tumor cell proliferation. Amer. J. Pathol. 168:321-330, 2006.
Spurdle, A.B., Antoniou, A.C., Kelemen, L., Holland H., Peock, S., Cook, M.R., Smith, P.L. Greene,M.H., Simard, J.,
Plourde, M., Southey, M., Godwin, A., Beck, J., Miron, A., Daly, M., Santella, R., Hopper, J., John, E.M., Andrulis,
I.L., Durocher, F., Struewing, J.P., ABCFS, AJBCS, BCFR, INHERIT, kConFaB, EMBRACE Study Collaborators, Easton,
D.F., and Chenevix-Trench, G. The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and
BRCA2 mutation carriers. Cancer Epidemiol, Biomarkers and Prev.15:76-79, 2006.
Bernstein, J.L., Teraoka, S.N., John, E.M., Andrulis, I.L., Knight, J., Lapinski, R., Olson, E.R., Wolitzer, A.L., Seminara.
D., Whittemore, A.S., and Concannon, P. The CHEK2*1100delC germline mutation and risk of breast cancer.
Cancer Epidemiol, Biomarkers and Prev. 15:348-352, 2006.
To, M.D., Gokgoz, N., Doyle, T.G., Donoviel, D., Knight, J.A., St. George Hyslop, P., Bernstein, A. and Andrulis, I.L.
Functional Characterization of Novel Presenilin-2 Variants Identified in Human Breast Cancers. Oncogene 25:35573564, 2006.
Smith, P., McGuffog, L., Easton, D.F., Mann, G.J., Pupo, G.M., Newman, B., Chenevix-Trench, G., kConFab
Szabo, C., Southey, M., Renard, H., Odefrey, F., Lynch, H., Stoppa-Lyonnet, D., Couch, F., Hopper, J.L., Buys, S.,
Andrulis, I.L., Senie, R., Breast Cancer Family Registry, BRCAX Collaborators group, Goldgar, D.E., Oldenburg, R.,
Kroeze-Jansema, K., Kraan, J., Meijers-Heijboer, H., Klijn, J.G.M., van Asperen, C., van Leeuwen, I., Vasen, H.F.A.,
Cornelisse, C.J., Devilee, P., Baskcomb, L., Seal, S., Barfoot, R., Mangion, J., Hall, A., Edkins, S., Rapley, E., Wooster,
R., Chang-Claude, J., Eccles, D., Evans, D.G., Futreal, P.A., Nathanson, K.L., Weber, B.L., Breast Cancer
Susceptibility Collaboration (UK), Rahman, N., Stratton, M.R. A genome wide linkage search for breast cancer
susceptibility genes. Genes, Chromosomes and Cancer 45: 646-655, 2006.
Pritchard K.I., Shepherd L.E., O’Malley F.P., Andrulis I.L., Tu D., and Levine M.N. for the National Cancer Institute
of Canada Clinical Trials Group. Neu/ErbB2 and responsiveness of breast cancer to adjuvant chemotherapy. New
England Journal of Medicine 354:2103-2111, 2006.
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Barsyte-Lovejoy, D., Lau, S.K., Boutros, P.C., Khosravi, F., Jurisica, I., Andrulis, I.L., Tsao, M.S., and Penn, L.Z. The
c-Myc oncogene directly induces H19 non-coding RNA by allele specific binding to potentiate tumorigenesis. Cancer
Research 66:5330-5337, 2006.
Onay, V.U., Briollais, L., Knight, J.A., Shi, E., Wang, Y., Wells, S., Li, H., Rajendram, I., Andrulis, I.L., and Ozcelik, H.
SNP-SNP Interactions in Breast Cancer Susceptibility. BMC Cancer. 6:114, 2006.
Dr. Azar Azad
Cohn TA, Remington G, Zipursky RB, Azad A, Connolly P, Wolever TMS; Insulin Resistance and Adiponectin levels in
drug-free patients with Schizophrenia: A preliminary Report. Can J Psychiatry, Vol 51, No 6, May 2006.
Knight JA, Thompson S, Raboud JM, Hoffman BR, Azad A. Light and exercise and melatonin production in women.
Oral presentation, Society for Epidemiologic Research and Canadian Society for Epidemiology and Biostatistics,
Toronto , Canada, American Journal of Epidemiology 161 (11 Suppl):S146, 2005, June 2005.
Dr. Bharati Bapat
Charames, G. and Bapat B. Cyclooxygenase-2 knockdown by RNA interference in colon cancer. Int J Oncol 28(2):
543-549, 2006.
Woods MO, Hyde AL, Curtis FK, Stuckless S, Green J, Pollett A, Robb JD, Green R, Croitoru M, Careen A, Chaulk
JAW, Jegathesan J, McLaughlin J, Gallinger S, Younghusband B, Bapat B, Parfrey PS. High frequency of hereditary
colorectal cancer in Newfoundland likely involved novel susceptibility genes. Clin Cancer Res 11(19): 6853-6861,
2005.
Lindor NM, Rabe K, Petersen G, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J,
LeMarchand L, Grove J, Potter J, Newcomb P, Terdiman JP, Conrad P, Moslein G, Goldberg R, Ziogas A, Anton-Culver
H, de Andrade M, Siegmund K, Thibodeau SN, Boardman LA, Seminara D. Lower cancer risks in Amsterdam-I
criteria families without mismatch repair deficiency. Journal of American Medical Association (JAMA) 293: 19861994, 2005
Durno, C.A., Aronson, M., Bapat, B., Cohen, Z., Gallinger. S. Family history and molecular features of children,
adolescents and young adults with colorectal carcinoma. Gut 54: 1146-1150, 2005.
Casey,G., Lindor, NM., Papadopoulos, N., Thibodeau, SN., Moskow, J., Steelman, S., Buzin, CH., Sommer SS.,
Collins, CE., Butz, M. Aronson, M., Gallinger, S., Barker MA., Young, JP., Jass, JR., Hopper JL., Diep, A., Bapat, B.,
Salem, M., Seminara, D. Haile, R. Colon Cancer Family Registry. Conversion analysis for mutation detection in MLH1
and MSH2 patients with colorectal cancer. JAMA 293: 799-809, 2005.
Chetty, R., Salahshor, S. Bapat, B., Berk, T., Croitoru, M., Gallinger S. Intraductal papillary mucinous neoplasm of
pancreas in a patient with attenuated familial adenomatous polyposis. J Clin Path 58: 97-101, 2005.
Dr. Terry Colgan
Snyder TM, Renshaw AA, Styer PE, Mody DR, Colgan TJ. Altered recognition of reparative changes in ThinPrep®
specimens in the College of American Pathologists Gynecologic Cytology Program. Arch Pathol Lab Med., 129:861-65,
2005.
Renshaw A, Mody DR, Wang E, Wilbur D, Colgan TJ. Measuring the significance of participant evaluation of
acceptability of cases in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal
Cytology. Arch Pathol Lab Med 129:1093-1096, 2005.
Guo J, Colgan TJ, DeSouza L, Rodrigues MJ, Romaschin AD, Siu KWM. Direct analysis of laser capture microdissected
endometrial carcinoma and epithelium by MALDI mass spectrometry. Rapid Communications in Mass Spectrometry 19:
2762-2766, 2005.
Colgan TJ: Disclosure of diagnostic errors: the death knell of retrospective pathology reviews? J. Lower Genital Tract
Disease 9: 216 – 8, 2005.
Renshaw A, Mody D, Wilbur D, Davey D, Colgan TJ. Letter-to-the Editor (Reply). Arch Pathol Lab Med. 130: 144 – 145,
2006.
Finch A, Shaw P, Rosen B, Murphy J, Narod SA, Colgan TJ. Clinical and pathologic findings of prophylactic salpingooophorectomies in 159 BRCA1 and BRCA2 carriers. Gynecol Oncol. 100: 58 – 64, 2006.
Milic A, Asch MR, Hawrylyshyn PA, Allen LM, Colgan TJ, Kachura JR, Hayeems EB. Laparoscopic ultrasound guided
radiofrequency ablation of uterine fibroids. Cardiovascular and Interventional Rad J. 2006.
Renshaw A, Mody D, Wang E, Haja J, Colgan TJ. Hyperchromatic Crowded Groups in Cervical Cytology: Differing
Appearances and Interpretations in Conventional and ThinPrep Preparations – A study from the College of American
Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology. Arch Pathol Lab Med. 2006 Mar;130:3326.
Renshaw A, Mody D, Styer P, Schwartz M, Ducatman B, Colgan TJ. Pap Tests with Mixed High and Low Grade
Squamous Intraepithelial Lesion Features: Distinct Performance in the College of American Pathologists Interlaboratory
Comparison Programme in Cervicovaginal Cytopathology. Arch Pathol Lab Med. 2006 Apr. 130: 456-9.
Dr. Greg Denomme
Denomme GA, Reid ME. Inaugural meeting of the consortium for blood group genes (CBGG): a summary report.
Immunohematology 21:129-131, 2005.
Denomme GA, Wagner FF, Fernandes BJ, Li W, Flegel WA. Partial D, weak D types, and novel RHD alleles among
33,864 multi-ethnic prospective transfusion recipients: implications for anti-D alloimmunization and prevention.
Transfusion 45:1554-1560, 2005.
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Dr. Eleftherios Diamandis
Michael IP, Sotiropoulou G, Pampalakis G, Magklara A, Ghosh M, Wasney G, Diamandis EP. Biochemical and
enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer
progression. J Biol Chem 2005;280:14628-14635.
Komatsu N, Saijoh K, Toyama T, Ohka R, Otsuki N, Hussack G, Takehara H, Diamandis EP. Multiple tissue kallikrein
mRNA and protein expression in normal skin and skin diseases. Br J Dermatol 2005;153:274-281.
Stephan C, Jung K, Soosaipillai A, Yousef GM, Cammann H, Meyer H, Xu C, Diamandis EP. Clinical utility of human
glandular kallikrein 2 within a neural network for prostate cancer detection. BJU Int 2005;96:521-527.
Yousef GM, White NMA, Michael IP, Cho JC, Robb JD, Kurlender L, Khan S, Diamandis EP. Identification of new
splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. Tumour
Biol 2005;26:227-235.
Obiezu CV, Shan SJ, Soosaipilla A, Luo LY, Grass L, Sotiropoulou G, Petraki CD, Papanastasiou PA, Levesque MA,
Diamandis EP. Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids.
Clin Chem 2005;51:1432-1442. Rosen DG, Wang L, Atkinson JN, Yu Y, Lu KH, Diamandis EP, Hellstrom I, Mok
SC, Liu J, Bast RC Jr. Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol
Oncol 2005;99:267-277.
Sidiropoulos M, Pampalakis G, Sotiropoulou G, Katsaros, D, Diamandis EP. Downregulation of human kallikrein 10
(KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers. Tumour Biol 2005;26:324336.
Yousef GM, Ejeckam GC, Best LM, Diamandis EP. Collecting duct carcinoma associated with oncocytoma: Int Braz J
Urol 2005;31:465-467.
Komatsu N, Saijoh K, Sidiropoulos M, Tsai B, Levesque MA, Elliott MB, Takehara K, Diamandis EP. Quantification
of human tissue kallikreins in the stratum corneum: dependence on age and gender. J Invest Dermatol
2005;125:1182-1189.
Petraki CD, Gregorakis AK, Vaslamatzis MM, Papanastasiou PA, Yousef GM, Levesque MA, Diamandis EP. Prognostic
implications of the immunohistochemical expression of human kallikreins 5, 6, 10 and 11 in renal cell carcinoma.
Tumour Biol 2006;27:1-7.
Brown DA, Stephan C, Ward RL, Law M, Hunter M, Bauskin AR, Amin J, Jung K, Diamandis EP, Hampton GM,
Russell PJ, Giles GG, Breit SN. Measurement of serum levels of macrophage inhibitory cytokine 1 combined with
prostate-specific antigen improves prostate cancer diagnosis. Clin Cancer Res 2006;12:89-96.
Simon I, Zhou S, Corral L, Diamandis EP, Sarno MJ, Wolfert RL, Kim NW. B7-H4 is a novel membrane-bound protein
and a candidate serum and tissue biomarker for ovarian cancer. Cancer Res 2006;66:1570-1575.
Fritzsche F, Gansukh T, Borgono C, Burkhardt M, Pahl S, Mayordomo E, Winzer KJ, Weichert W, Denkert C, Jung
K, Stephan C, Dietel M, Diamandis EP, Dahl E, Kristiansen G. Expression of human kallikrein 14 (KLK14) in breast
cancer is associated with higher tumour grades and positive nodal status. Br J Cancer 2006;94:540-547.
Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP. Human Kallikrein 6 expression in salivary gland tumors. J
Histochem Cytochem 2006;54:337-342.
Luo L-Y, Shan SJC, Elliott MB, Soosaipillai A, Diamandis EP. Purification and characterization of human kallikrein 11,
a candidate prostate and ovarian cancer biomarker, from seminal plasma. Clin Cancer Res 2006;12:742-750.
Slagter MH, Gooren LJ, de Ronde W, Soosaipillai A, Giltay EJ, Paliouras M, Diamandis EP. Serum and urine tissue
kallikrein concentrations in male-to-female transsexuals treated with antiandrogens and estrogens. Clin Chem
2006;52:1356-1365.
Parr RL, Dakubo GD, Grandall KA, Maki J, Reguly B, Aguirre A, Wittock R, Robinson K, Alexander JS, Birch-Machin
MA, Abdel-Malak M, Froberg MK, Diamandis EP, Thayer RE. Somatic mitochondrial DNA mutations in prostate
cancer and normal appearing adjacent glands in comparison to age-matched prostate samples without malignant
histology. J Mol Diagn 2006;8:312-319.
Prezas P, Arlt MJ, Viktorov P, Soosaipillai A, Holzscheiter L, Schmitt M, Talieri M, Diamandis EP, Kruger A, Magkolen
V. Overexpression of human tissue kallikrein genes KLK4, 5, 6 and 7 increases the malignant phenotype of ovarian
cancer cells. Biol Chem 2006;387:807-811.
Stephan C, Meyer HA, Cammann H, Nakamura T, Diamandis EP, Jung K. Improved prostate cancer detection with a
human kallikrein 11 and percentage free PSA-based artificial neural network. Biol Chem 2006;387:801-805.
Pampalakis G, Diamandis EP, Sotiropoulou G. The epigenetic basis for the aberrant expression of kallikreins in
human cancers. Biol Chem 2006;387:795-799.
Obiezu CV, Michael IP, Levesque MA, Diamandis EP. Human kallikrein 4: enzymatic activity, inhibition and
degradation of extracellular matrix proteins. Biol Chem 2006;387:749-759.
Memari N, Grass L, Nakamura T, Karakucuk I, Diamandis EP. Human kallikrein 9: Production of recombinant
proteins and specific antibodies. Biol Chem 2006;387:733-740.
Kishi T, Cloutier SM, Kundig C, Deperthes D, Diamandis EP. Activation and enzymatic characterization of
recombinant human kallikrein 8. Biol Chem 2006;387:723-731.
Felber LM, Kundig C, Borgono CA, Chagas JR, Tasinato A, Jichlinski P, Gygi CM, Leisinger H-J, Diamandis EP,
Deperthes D, Cloutier SM. Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14. FEBS J
2006;273:2505-2514.
Santin AD, Diamandis EP, Bellone S, Marizzoni M, Bandiera E, Palmieri M, Papasakelariou C, Katsaros D, Burnett
A, Pecorelli S. Overexpression of kallikrein 10 (hK10) in uterine serous papillary carcinoma. Am J Obstet Gynecol
2006;194:1296-1302.
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Diamandis EP. Serum proteomic profiling by matrix-assisted laser desorption-ionization time-of-flight mass
spectrometry for cancer diagnostics: next steps. Cancer Res 2006;66:5540-5541.
Stephan C, Jung K, Nakamura T, Yousef GM, Diamandis EP. Serum human glandular kallikrein 2 (hK2) for
distinguishing stage and grade of prostate cancer. Int J Urol 2006; 13:238-243.
Oikonomopoulou K, Scorilas A, Michael IP, Grass L, Soosaipillai A, Rosen B, Murphy J, Diamandis EP. Kallikreins as
markers of disseminated tumour cells in ovarian cancer – a pilot study. Tumour Biol 2006;27:104-114.
Borgo�o CA, Kishi T, Scorilas A, Harbeck N, Dorn J, Schmalfeldt B, Schmitt M, Diamandis EP. Human kallikrein 8
protein is a favorable prognostic marker in ovarian cancer. Clin Cancer Res 2006;12:1487-1493.
Michael IP, Pampalakis G, Mikolajczyk SD, Malm J, Sotiropoulou G, Diamandis EP. Human tissue kallikrein 5 is a
member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer
progression. J Biol Chem 2006;281:12743-12750.
Stephan C, Xu C, Brown DA, Breit SN, Michael A, Nakamura T, Diamandis EP, Meyer H, Cammann H, Jung K. Three
new serum markers for prostate cancer detection within a percent free PSA-based artificial neural network. Prostate
2006;66:651-659.
Dr. Bernard Fernandes
von Dadelszen P, Sermer M, Millier J, Allen LC, Fernandes BJ, Johnson JA, Shime J, Winsor EJ, Ryan G. A randomized
controlled trial of biopsy forceps and cannula aspiration for transcervical chorionic villus sampling. BJOG 2005
may:112(5):559-566.
Denomme GA, Wagner FF, Fernandes BJ, Li W, Flegel WA. Partial D, weak D types, and novel RHD alleles
among 33,864 multiethnic patients: implications for anti-D alloimmunization and prevention. Transfusion 2005
Oct:45(10):1554-1560.
Chetty R, Salahshor S, Bapat B, Berk T, Croitoru M, Gallinger S. Intraductal papillary mucinous neoplasm of
pancreas in a patient with attenuated familial adenomatous polyposis. J Clin Path 2005: 58 pp 97-101.
Dixon E, Vollmer CM, Sahajpal A, Cattral M, Grant D, Doig C, Hemming A, Taylor B, Langer B, Greig P, Gallinger S.
A 12 year cohort study at a North American Center: adoption of an aggressive surgical approach leads to improved
survival in patients with gallbladder cancer. Annals of Surgical Oncology 2005: 241(3) pp 385-394
Casey G, Lindor NM, Papadopoulos N, Thibodeau SN, Moskow J, Steelman S, Buzin CH, Sommer SS, Collins CE,
Butz M, Aronson M, Gallinger S, Barker MA, Young JP, Jass JR, Hopper JL, Diep A, Bapat B, Salem M, Seminara D,
Haile R, Colon Cancer Family Registry. Conversion analysis for mutation detection in MLH1 and MSH2 patients with
colorectal cancer. JAMA 2005: 293(7): pp 799-809.
Jaskolka JD, Asch MR, Kachura JR, Ho CS, Ossip M, Wong F, Sherman M, Grant DR, Greig PD, Gallinger S. Needle
tract seeding after radiofrequency ablation of hepatic tumors. J Vasc Interv Radiol 2005: 16(4): pp 485-491.
Dixon E, Jr CM, Sahajpal A, Cattral MS, Grant DR, Taylor BR, Langer B, Gallinger S, Greig PD. Transduodenal
resection of peri-ampullary lesions. World J Surg 2005: 29: pp 649-652.
Durno CA, Aronson M, Bapat B, Cohen Z, Gallinger S. Family history and molecular features of children,
adolescents and young adults with colorectal carcinoma. Gut 2005:54: pp 1146-1150.
Lindor NM, Rabe K, Petersen G, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J,
LeMarchand L, Grove J, Potter J, Newcomb P, Terdimann J, Conrad P, Moslein G, Ziogas A, Anton-Culver H,
Goldberg R, Thibodeau SN, Boardman L, Seminara D. Lower cancer risks in Amsterdam-I criteria families without
mismatch repair deficiency. JAMA 2005: 293(16): pp 1979-1985.
Gryfe R, Gallinger S. Germline PMS2 mutations: one hit or two? Gastroenterology 2005: 128(5): pp 1506-1509.
Kim R, Sakamoto S, Haider M, Molinari M, Gallinger S, McGilvray I, Greig P, Grant D, Cattral MS. Role of magnetic
resonance imaging in assessing biliary anatomy in right lobe living donors. Transpl 2005: 79(10): pp 1417-1421.
Ramji F, Cotterchio M, Manno M, Rabeneck L, Gallinger S. Association between subject factors and colorectal
cancer screening participation in Ontario Canada. Cancer Detection and Prevention 2005: 29: pp 221-226.
Batlle E, Bacani J, Begthel H, Jonkeer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T,
Gallinger S, Pals S, Clevers H. EphB activity suppresses colorectal cancer progression. Nature 2005: 435(7045): pp
1126-1130.
Salahshor S, Goncalves J, Chetty R, Gallinger S, Woodgett JR. Differential gene expression profile reveals
deregulation of pregnancy specific beta-1 glycoprotein 9 early during colorectal carcinogenesis. BMC Cancer 2005:
5(1) pp 66.
Suriano G, Yew S, Ferreira P, Senz J, Kaurah P, Ford JM, Longacre TA, Norton JA, Chun N, Young S, Oliveira MJ,
MacGillivray B, Rao A, Sears D, Jackson CE, Boyd F, Yee C, Deters C, Pai GS, Hammond LS, McGivern BJ, Medgyesy
D, Sartz D, Arun B, Oelschlager BK, Upton MP, Neufeld-Kaiser W, Silva OE, Donenberg TR, Kooby DA, Sharma S,
Jonsson B-A, Gronberg H, Gallinger S, Seruca R, Lynch H, Huntsman DG. Characterization of a recurrent germ line
mutation of the E-cadherin gene: implications for genetic testing and clinical management. Human Cancer Biology
2005: 11(15) pp 5401-5409.
Cotterchio M, Manno M, Klar N, McLaughlin J, Gallinger S. Colorectal screening is associated with reduced
colorectal cancer risk: a case-control study within the population-based Ontario Familial Colorectal Cancer Registry.
Cancer Causes and Control 2005: 16(7): pp 865-875.
Woods MO, Hyde AL, Curtis FK, Stuckless S, Green J, Pollett A, Robb JD, Green R, Croitoru M, Careen A, Chaulk
JAW, Jegathesan J, McLaughlin J, Gallinger S, Younghusband B, Bapat B, Parfrey PS. High frequency of hereditary
colorectal cancer in Newfoundland likely involved novel susceptibility genes. Clin Cancer Res 2005: 11(19): pp
6853-6861.
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Bacani J, Zwingerman R, Di Nicola N, Spencer S, Wegrynowski T, Mitchell K, Hay K, Redston M, Holowaty E,
Huntsman D, Pollett A, Riddell R, Gallinger S. Tumor microsatellite instability in early onset gastric cancer. J Mol
Diagn 2005: 7(4): pp 465-477.
Fazio L., Cotterchio M, Manno M, Mclaughlin J, Gallinger S. Association between colonic screening, subject
characteristics, and stage of colorectal cancer. Am J Gastroenterol 2005: 100(11): pp 2531-2539.
Hitchins M, Williams R, Cheon K, Halani N, Ap-Lin V, Packham D, Ku S, Buckle A, Hawkins N, Burn J, Gallinger
S, Goldblatt J, Kirk J, Tomlinson I, Scott R, Spigelman A, Suter C, Martin D, Suthers G, Ward, R. MLH1 germline
epimutations as a factor in hereditary non-polyposis colorectal cancer. Gastroenterology 2005: 129(5): pp 13921399.
Mackay HJ, Billingsley K, Gallinger S, Berry S, Smith A, Yeung R, Pond GR, Croitoru M, Swanson PE, Krishnamurthi
S, Siu LL. A multicenter phase II study of “Adjuvant” irinotecan following resection of colorectal hepatic metastases.
Am J Clin Oncol 2005:28(6) pp 547-554.
Johnson PM, Gallinger S, Mcleod RS. Surveillance colonoscopy in individuals at risk for hereditary nonpolyposis
colorectal cancer: an evidence-based review. Dis Colon Rectum 2006: 49(1): pp 80-93.
Kim RD, Kundal PS, McGilvray ID, Cattral MS, Taylor B, Langer B, Grant DR, Zogopoulos G, Shah SA, Greig PD,
Gallinger S. Predictors of failure following pancreaticoduodenectomy for ampullary carcinoma. J Am Coll Surg
2006: 202(1) pp 112-119.
Shah SA, Greig PD, Gallinger S, Cattral MS, Dixon E, Kim RD, Taylor BR, Grant DR, Vollmer CM. Factors associated
with early recurrence after resection for hepatocellular carcinoma and outcomes. J Am Coll Surg 2006: 202(2) pp
275-283.
Wei AC, Greig PD, Grant D, Taylor B, Langer B, Gallinger S. Survival after hepatic resection for colorectal
metastases: a 10-year experience. Ann Surg Oncol 2006: 13(5) pp 668-676.
Jenkins M, Croitoru ME, Monga N, Cleary S, Cotterchio M, Hopper J, Gallinger S. Risk of colorectal cancer in
monoallelic and biallelic carriers of MYH mutations: a population-based case-family study. Cancer Epidemiol
Biomarkers Prev 2006: 15(2) pp 312-314.
Shah SA, Haddad R, Al-Sukhni W, Kim RD, Greig PD, Grant DR, Taylor BR, Langer B, Gallinger S, Wei AC. Surgical
resection of hepatic and pulmonary metastases from colorectal carcinoma. J Am Coll Surg 2006: 202(3) pp 468475.
Petersen GM, de Andrade M, Goggins M, Hruban RH, Bondy M, Korczak JF, Gallinger S, Lynch HT, Syngal S, Rabe
KG, Seminara D, Klein AP. Pancreatic cancer genetic epidemiology consortium. Cancer Epidemiol Biomarkers Prev
2006: 15(4) pp 704-710.
Durno CA, Gallinger S. Genetic Predisposition to Colorectal Cancer: New Pieces in the Pediatric Puzzle. J Pediatr
Gastroenterol Nutr. 2006: 43(1) pp 5-15.
Bacani JT, Soares M, Zwingerman R, Di Nicola N, Senz J, Riddell R, Huntsman D, Gallinger S. CDH1/E-cadherin
germline mutations in early onset gastric cancer. J Med Genet. June 2006 Epub.
Fishman PN, Pond GR, Moore MJ, Oza A, Burkes RL, Siu LL, Feld R, Gallinger S, Greig P, Knox JJ. Natural history
and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113
cases. Am J Clin Oncol. 2006: 29(3) pp 225-31.
Dr. Marc Grynpas
Vieira, APGF; Hancock, R; Dumitriu, Schwartz, M; Limeback, H and Grynpas MD
How does Fluoride affect dentin microhardness and mineralization? J Dent Res
Oct 84(10): 951-7, 2005.
Veira, APGF, Mousny, M, Maia, R, Hancock, R, Everett, ET, Grynpas, MD. Assessment of teeth as biomarkers for
skeletal Fluoride exposure. Osteoporosis Int. Dec;16(12): 1576-82, 2005.
Banse X, Devogelaer JP, Holmyard D, Grynpas MD. Vertebral cancellous bone turn- over: microcallus and bridges in
backscatter electron microscopy. Micron, 36(7-8): 710-4, 2005.
Vieira, APGF; Hancock, R; Dumitriu, M; Limeback, H and Grynpas, MD. Fluoride’s effect on human dentin
ultrasound velocity (elastic modulus) and tubule size. Euro J Oral Science. Feb; 114(1): 83-8, 2005.
Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JEI, Gong
XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GIL,
Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai B, Bruneau BG, Grynpas MD, Henderson
JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1
missense mutation in a mouse model of Oculodentodigital Dysplasia (ODDD). Development. Oct; 132(19): 437586, 2005.
Wise LM, Waldman SD, Kasra M, Cheung R, Binnington, Kandel RA, White LM, Grynpas MD. Effect of zoledronate
on bone quality in the treatment of aseptic loosening of hip arthroplasty in the dog. Calcif Tissue Int. 77(6): 36775, December 2005.
Facchini DM, Yuen VG, Battell ML, McNeill JH, Grynpas MD. The Effects of
Vanadium Treatment on Bone in Diabetic and Non-Diabetic Rats. Bone, Vol 38,
Issue 3, March, 368-377, 2006.
Waldman SD, Couto DC, Grynpas MD, Pilliar RM, Kandel RA . A single application of cyclic loading can accelerate
matrix deposition and enhance the properties of tissue-engineered cartilage. Osteoarthritis and Cartilage, Vol.14,
323-330, 2006.
Kandel RA, Grynpas MD, Pilliar RM, Lee J, Wang J, Waldman SD, Zalzal P, Hurtig MB Repair of osteochondral
defects with biphasic cartilage-calcium Polyphosphate constructs in a sheep model. Biomaterials, Aug; 27(22):
4120-31, 2006.
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Dr. Barry Hoffman
Knight JA, Thompson S, Raboud JM, Hoffman BR. Light and exercise and melatonin production in women.
American Journal of Epidemiology 162:1-9, 2005.
Dr. David Howarth
Sivak-Callcott JA, Lim WK, Seah LL, Oestreicher J, Rossman D, Nijhawan N, Rootman J, White V, Williams HJ,
Chang WW, DiBartolomeo A, Howarth D. Xanthogranulomatous disease in the lacrimal gland. Br J Ophthalmol.
89(10):1375-7, 2005.
Dr. Rita Kandel
Séguin CA, Pilliar RM, Roughley PJ, Kandel RA. Tumor necrosis factor-alpha modulates matrix production and
catabolism in nucleus pulposus tissue. Spine. 30(17):1940-8, 2005.
Chhaya S, White LM, Kandel R, Wunder JS, Ferguson P, Agur A. Transarticular invasion of bone tumours across the
sacroiliac joint. Skeletal Radiology Sep 24:1-7, 2005.
Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J. Granular cell tumor of the extremity:
magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiology 34(10):625-31, 2005.
Wise LM, Waldman SD, Kasra M, Cheung R, Binnington A, Kandel RA, White LM, Grynpas MD. Effect of
Zoledronate on Bone Quality in the Treatment of Aseptic Loosening of Hip Arthroplasty in the Dog. Calcif Tissue
Int. 77(6):367-75, 2005.
Hamilton DJ, Séguin CA, Wang J, Pilliar RM, Kandel RA. Formation of a Nucleus Pulposus-Cartilage Endplate
Construct in Vitro. Biomaterials. 27(3):397-405, 2006.
Kandel R, Li SQ, Bell R, Wunder J, Ferguson P, Kauzman A, Diehl JA, Werier J. Cyclin D1 and p21 is Elevated in the
Giant Cells of Giant Cell Tumors. Journal of Orthopaedic Research 24(3):428-37, 2006.
Waldman SD, Couto DC, Grynpas MD, Pilliar RM, Kandel RA. A single application of cyclic loading can accelerate
matrix deposition and enhance the properties of tissue-engineered cartilage. Osteoarthritis and Cartilage 14(4):32330, 2006.
Kandel RA, Grynpas M, Pilliar R, Lee J, Waldman S, Zalzal P, Hurtig M. Repair of Osteochondral Defects with
Biphasic Cartilage-Calcium Polyphosphate Constructs In a Sheep Model. Biomaterials 27(22):4120-31, 2006.
Dr. Sarah Keating
Finkelstein, Y, Chitayat, D., Schechter, T., Keating, S., Toi, A., Koren, G. Warfarin
Embryopathy Following
Low Dose Maternal Exposure. Accepted by Obstetrics and
Gynecology, Canada 27(7): 702-706, July
2005.
Ellis, C., Pymar, H., Keating, S., Kingdom, J. Non-compaction of the fetal ventricular myocardium presenting with
reversed end-diastolic flow velocity in the umbilical arteries. JOGC, 27(7):695-698, 2005.
Slevin, J., Blaser, S., Chitayat, D., Berger, H., Halliday, W., Keating, S., Ryan, G., Toi, A., Pantazi, S., Raybaud,
C. “Intraventricular fused fornices”, a marker for complex midline anomalies. Ultrasound in Obstetrics and
Gynecology, 26(4): 311, 2005.
McAuliffe, F.M., Fong, K.W., Toi, A., Chitayat, D., Keating, S., Johnson, J.A. Ultrasound detection of fetal anomalies
in conjunction with first-trimester nuchal translucency screening: a feasibility study. American Journal of Obstetrics
and Gynecology,
193(3 Pt 2):1260-1265, 2005.
Redline, R.W., Heller, D., Keating, S., Kingdom, J. Placental diagnostic criteria and clinical correlation – A workshop
report. Placenta, 26(Suppl. A):S114-S117, 2005.
Dr. Elena Kolomietz
Kolomietz E, Chitayat D, Teshima I. Array-based mapping of the breakpoint regions of familial partial trisomy
11q14.1q22.1 associated with mood disorders for identification of candidate depression-related genes. Am J Med
Genet B Neuropsychiatr Genet. 141(3):214-9., 2006.
Dr. Iona Leong
Donovan JCH, Hayes RC, Burgess K, Leong IT, Rosen CF. Refractory erosive oral lichen planus associated with
Hepatitis C: Response to topical tacrolimus ointment. J Cutan Med Surg. 9(2):43-6, 2005.
Dardick I, Bradley G, Lee L, Leong I. Salivary Gland Oral and Surgical Pathology CD-ROM, 2006.
Audet N, Beasley NJ, MacMillan C, Jackson DJ, Gullane PJ, Kamel-Reid S. Lymphatic Vessel Density, nodal
metastases, and prognosis in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg.,131(12) 106570, 2005.
Mäkitie AA, Reis PP, Arora S, MacMillan C, Warner GC, Sukhai M, Dardick I, Perez-Ordonez B, Wells R, Brown D,
Gilbert R, Freeman J, Gullane P, Irish J, Kamel-Reid S
Molecular characterization of salivary gland malignancy using the Smgb-Tag transgenic mouse model. Lab Invest.
(Epub ahead of print); Aug;85 (8):947-61, 2005.
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Dr. Brendan Mullen
Aoki VW, Moskovtsev SI, Willis J, Liu L, Mullen JBM, Carrell DT. DNA integrity is compromised in protamine-deficient
human sperm. J Androl, 26:741-8, 2005.
Moskovtsev SI, Willis J, Mullen JBM. Age-related decline in sperm DNA integrity in patients evaluated for male
infertility. Fertil Steril, 85:496-9, 2006.
AL Bane, S Tjan, RK Parkes, I Andrulis, FP O’Malley. Invasive lobular carcinoma: to grade or not to grade. Modern
Pathology. 18:621-628, 2005.
AM. Chiarelli, V Mai, EE. Halapy, RS. Shumak, FP O’Malley, NS. Klar. Effect of screening result on waiting times to
assessment and breast cancer diagnosis: Results from the Ontario Breast Screening Program. Canadian Journal of
Public Health 96:259-263, 2005.
AL Bane, S Tjan, RK Parkes, I Andrulis, FP O’Malley. Invasive lobular carcinoma: to grade or not to grade. Modern
Pathology. 18:621-628, 2005.
TL Mastracci, S Tjan, AL Bane, FP O’Malley, IL Andrulis. E-cadherin alterations in atypical lobular hyperplasia and
lobular carcinoma in situ of the breast. Modern Pathology. 18:741-751, 2005.
M. Trudeau, S.E. Sinclair, M. Clemons, Breast Cancer Disease Site Group including FP O’Malley. Neoadjuvant
taxanes in the treatment of non-metastatic breast cancer: a systematic review. Cancer Treat Rev. 31:283-302, 2005.
A. Chiarelli, E Halapy, V Nadalin, R Shumak, FP O’Malley, V Mai. Performance measures from 10 years of breast
screening in the Ontario Breast Screening Program, 1990/91-2000. Eur J Cancer Prev. 15:34-42, 2006.
FP O’Malley, SK. Mohsin, Sunil Badve, S Bose, MD, LC Collins, M Ennis, CG Kleer, SE Pinder, and SJ Schnitt MD
Interobserver Reproducibility in the Diagnosis of flat epithelial atypia of the breast. Modern Pathology. 19:172-179,
2006.
T A Longacre, M Ennis, L Quenneville, A Bane M.D, I Bleiweiss, B Carter, E Catelano, MR Hendrickson, H Hibshoosh,
L Layfield, L Memeo, H Wu, FP O’Malley. Interobserver agreement and reproducibility in diagnosis and classification
of invasive carcinoma of the breast: results of the National Cancer Institute (NCI) Familial Registry Breast Cancer
Pathology Working Group. Modern Pathology. 19:195-207, 2006
KI Pritchard, LE Shepherd, FP O’Malley, I Andrulis, DTu, MN Levine. HER2 and Responsiveness of Breast Cancer to
Adjuvant Chemotherapy. New Eng J Med 354: 2103-2111; 2006 (Accompanying editorial: MJ Piccart-Gebhart.
Anthracyclines and the tailoring of treatment for early breast cancer. New Eng J Med 354: 2177-2179; 2006)
Dr. Hilmi Özçelik
Savas S, Ozcelik H. Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs. BMC
Cancer 5(1): 107, 2005.
Cho S, Savas S, Ozcelik H. Genetic variation and the mitogen-activiated protein kinase (MAPK) signaling pathway.
OMICS 10(1): 66-81, 2006.
Savas S, Tuzmen S, Ozcelik H. Human SNPs resulting in premature stop codons and protein truncation. Hum
Genomics 2(5): 274-286, 2006.
Savas S, Schmidt S, Jarjanazi H, Ozcelik H. Functional nsSNPs from carcinogenesis related genes expressed in breast
tissue: Potential breast cancer risk alleles and their distribution across human populations. Hum Genomics 2(5): 287296, 2006.
Onay VU, Briollais L, Knight JA, Shi E, Wang Y, Wells S, Li H, Rajendram I, Andrulis IL, Ozcelik. H. SNP-SNP
interactions in breast cancer susceptibility. BMC Cancer 6(1): 114, 2006.
Prigoda NL, Savas S, Abdalla SA, Piovesan B, Rushblow D, Vandezande KE, Zhang EK, Ozcelik H. Gallie BL, Letarte
M. Hereditary haemorrhagic telangiectasia: mutation detection, test sensitivity and novel mutations. J Med Genet.
Epub May 2006.
Pennell CE, Jacobsson B, Williams SM, Buus RM, Muglia LJ, Dolan SM, Morken NH, Ozcelik H, Lye SJ, Prebic
Genetics Working Group, Relton C. Genetic epidemiological studies of preterm birth: Guidelines for research. Am J
Obstet Gynecol epub May 2006.
Dr. Aaron Pollett
Woods M, Hyde A, Curtis F, Stuckless S, Green J, Pollett A, Robb D, Green R, Croitoru M, Careen A, Chaulk
J, Jegathesan J, McLaughlin J, Gallinger S, Younghusband B, Bapat B, Parfrey P. High Frequency of Hereditary
Colorectal Cancer in Newfoundland Likely Involves Novel Susceptibility Genes. Clinical Cancer Research
11(19):6853 – 6861, 2005.
Bacani J, Zwingerman R, DiNicola N, Spencer S, Wegrynowski t, Mitchell K, Hay K, Redston M, Holowaty E,
Huntsman D, Pollett A, Riddell R, Gallinger S. Tumour microsatellite instability in early onset gastric cancer. Journal
of Molecular Diagnostics 7(4):465 – 477, 2005.
Ko MA. Rosario CO. Hudson JW. Kulkarni S. Pollett A. Dennis JW. Swallow CJ. Plk4 haploinsufficiency causes mitotic
infidelity and carcinogenesis. Nature Genetics. 37(8):883-8, 2005.
Yu C, Canteenwala T, Chiang LY, Wilson B, Pritzker KPH: Photodynamic effect of hydrophilic C60-derived
nanostructures for catalytic antitumoral antibacterial application. Synthetic Metals 153: 37-40, 2005.
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Verma S, Padmawar PA, Hauck T, Canteenwala T, Chiang LY, Pritzker KPH: Synthesis of water-soluble highly twophoton responsive [60]fullerene-diphenylaminofluorene chromophore dyads. J Macromol Sci Pure Appl Chem 42:
1497-1505, 2005.
Pritzker KPH, Azad A: Bringing biomarkers to clinical practice. Clinical Lab International 25: 24-26, November
2005.
Pritzker KPH, Gay S, Jimenez SA, Ostergaard K, Pelletier J-P, Revell PA, Salter D: Osteoarthritis cartilage
histopathology: grading and staging. Osteoarthritis and Cartilage 14: 13-29, January 2006.
Dr. Richard Renlund
Kotsopoulos J, Medline A, Renlund R, Sohn K-J, Martin R, Hwang S, Lu S, Archer M and KimY-I: Effects of dietary
folate on the development and progression of mammary tumours in rats. Carcinogenesis 26: 1603-1612, 2005.
Dr. Robert Riddell
Silverberg MS, Satsangi J, Ahmad T, Arnott I, Bernstein CN, Brant MD, Caprilli R,
Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus EV, Peña AS,
Riddell R H, Sachar DB, Schreier S, Steinhart AH, Targan SR, Vermeire S, Warren BF. Toward an integrated clinical,
molecular and serological classification of inflammatory Bowel disease: Report of a Working Party of the 2005
Montreal World Congress of
Gastroenterology. Can J Gastroenterol. 19 Suppl A:5-36, 2005.
Al-Haddad S, Riddell RH. The role of eosinophils in inflammatory bowel disease Gut. 54(12):1674-5, 2005.
Bacani J, Zwingerman R, Di Nicola N, Spencer S, Wegrynowski T, Mitchell K, Hay K, Redston M, Holowaty E,
Huntsman D, Pollett A, Riddell R, Gallinger S. Tumor Microsatellite Instability in Early Onset Gastric Cancer, J Mol
Diagn. 7(4):465-77, 2005.
Cunningham KS, Riddell RH. Serrated mucosal lesions of the colorectum.
Curr Opin Gastroenterol. 22(1): 48-53, 2006.
Bresalier R S, Sandler R S, Quan H, Bolognese JA, Oxenius B, Horgan K, Lines C, Riddell RH, Morton D, Lanas
A, Konstam MA, Baron JA, for the Adenomatous polyps Prevention on Vioxx (APPROVe) Trial Investigators.
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial, N Engl J. Med.
355(2):221, 2006.
Blackstein M, Blay Jean-Yves, Riddell, HR, et al Gastrointestinal stromal tumours (GIST): Consensus statement of
diagnosis and treatment. Canadian Journal of Gastroenterology. 20(3) 157-163, 2006.
Dr. Patrick Shannon
Shannon P, Bilbao JM, Marotta T, Terbrugge K Inadvertent foreign body embolization in diagnostic and therapeutic
cerebral angiography. AJNR Am J Neuroradiol. (2):278-82, 2006.
Shannon P, Sabha N, Lau N, Kamnasaran D, Gutmann DH, Guha A. Pathological and molecular progression of
astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. Am J Pathol. 167(3):859-67, 2005.
Laxton AW, Shannon P, Nag S, Farb RI, Bernstein M. Rapid expansion of a previously asymptomatic
subependymoma. Case report. J Neurosurg. 103(6):1084-7, 2005.
Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H,
McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP.Tyrosine phosphatase MEG2
modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp
Med. 202(11):1587-97, 2005.
Zadeh G, Reti R, Koushan K, Baoping Q, Shannon P, Guha A. Regulation of the pathological vasculature of
malignant astrocytomas by angiopoietin-1. Neoplasia. (12):1081-90, 2005.
Walji S, Rubenstein J, Shannon P, Carette S. Disseminated pyomyositis Disseminated pyomyositis mimicking
idiopathic inflammatory myopathy. J Rheumatol. 32(1):184-7, 2005.
Dr. Howard Tenenbaum
Rittenberg, B., Partridge, E., Baker, G., Clokie, C., Zohar, R., Dennis, J.W., Tenenbaum, H.C. Regulation of BMPinduced ectopic bone formation by Ahsg Journal of Orthopaedic Research, May,23(3)653-662, 2005.
Chun, Y.H., Foster, B.L., Lukasavage, P.A., Berry, J.E., Zhao, M., Tenenbaum, H.C., Somerman, M.J. Bisphosphonate
modulated cementoblast behavior in vitro J. Periodontology , 76(11), 890-990, Nov, 2005.
Shoval, I., Kushner, J. Sukhu, B., Wood, R., Kiss, T. Lawrence, Tenenbaum, H. . The relationship between
mouthrinse matrix metalloproteinases (MMP-1, 8, 13) and albumin levels with the degree of oral mucositis in
allogeneic stem cell transplant patients. Bone Marrow Transplantation (1-6) pg. 654-662, 2005.
Voronov, I., Heersche, J.N.M., Casper, R.F., Tenenbaum, H.C., Manolson, M.F. Inhibition of osteoclast differentiation
by polycyclic aryl hydrocarbons is dependent on cell density and RANKL concentration. Biochemical Pharmacology.
Biochem Pharmacol. May 2005.
Lekic, P.C., Nayak, B.N., Al-Sanea, R., Tenenbaum, H.C., Ganss, B., McCulloch, C. Cell transplantation in wounded
mixed connective tissues. Anat Rec A Discov Mol Cell Evol Biol. Dec, 287(2): 1256-63, 2005.
Zohar, R., Tenenbaum, H.C. How predictable are periodontal regenerative procedures? Journal of the Canadian
Dental Association, Oct. 71(9)675-80, 2005.
Bhide, V., Goldberg, M., Tenenbaum, H.C. Characterization of patients presenting for treatment to a University
Refractory Periodontal Diseases Unit: 3 case reports. J. Periodontol, Feb. 77(2)316-322, 2006.
| 65
Barrett, E.J., Kenny, D.J., Tenenbaum, H.C., Sigal, M.J., Johnston, D.H. Replantation of permanent incisors in children
using Emdogain. Dental Traumatology 21: 269-275,
2005.
Shoval, R. and Tenenbaum, H.C. Treatment of a mandibular furcation with enamel matrix. Ontario Dentist 83(3):2629, 2006.
Tenenbaum, H.C. and Goldberg, M. What should I discuss with my patients who have diabetes and periodontal disease
and how should this affect management their periodontal problems? JCDA 72:38-39, 2006.
Van der Aa MN, van Leenders GJ, Steyerberg EW, van Rhijn BW, Jobsis AC, Zwarthoff EC, Van der Kwast TH. A new
system for substaging pT1 papillary bladder cancer: a prognostic evaluation. Hum Pathol. 36(9):981-6, 2005.
Van Duin M, van Marion R, Vissers K, Watson JE, van Weerden WM, Schroder FH, Hop WC, Van der Kwast TH, Collins
C, van Dekken H. High-resolution array comparative genomic hybridization of chromosome arm 8q: evaluation of
genetic progression markers for prostate cancer. Genes Chromosomes Cancer. 44(4):438-49, 2005.
Schroder FH, Raaijmakers R, Postma R, Van der Kwast TH, Roobol MJ. 4-year prostate specific antigen progression and
diagnosis of prostate cancer in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam.J
Urol. 174(2):489-94, 2005.
Ma X, Ziel-van der Made AC, Autar B, van der Korput HA, Vermeij M, van Duijn P, Cleutjens KB, de Krijger R,
Krimpenfort P, Berns A, Van der Kwast TH, Trapman J. Targeted biallelic inactivation of Pten in the mouse prostate leads
to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res.
65(13):5730-9, 2005.
van der Cruijsen-Koeter IW, Vis AN, Roobol MJ, Wildhagen MF, de Koning HJ, Van der Kwast TH, Schroder FH.
Comparison of screen detected and clinically diagnosed prostate cancer in the European randomized study of screening
for prostate cancer, section Rotterdam. J Urol 174(1):121-125, 2005.
Postma R, van Marion R, van Duin M, Vissers KJ, Schroder FH, Tanke HJ, Szuhai K, Van der Kwast TH, van Dekken H.
Array-based genomic analysis of screen-detected Gleason score 6 and 7 prostatic adenocarcinomas. Anticancer Res.
(2A): 1193-200, 2006.
Van der Kwast TH, Roobol MJ. Can PSA density be used to detect prostate cancer? Nat Clin Pract Urol. (3): 130-1,
2006.
Roemeling S, Roobol MJ, de Vries SH, Gosselaar C, Van der Kwast TH, Schroder FH. Prevalence, treatment modalities
and prognosis of familial prostate cancer in a screened population.J Urol. 175 (4): 1332-6, 2006.
Schroder FH, Roobol MJ, Van der Kwast TH, Kranse R, Bangma CH. Does PSA velocity predict prostate cancer in prescreened populations? Eur Urol. 2006 March: 49 (3): 460-5: discussion 465. Epub 2006.
Postma R, van Leenders GJ, Roobol MJ, Schroder FH, Van der Kwast TH. Tumor Features in the Control and
Screening Arm of A Randomized Trial of Prostate Cancer.Eur Urol. (Epub ahead of print), 2005.
Van der Kwast TH. Substaging pathologically organ confined (pT2) prostate cancer: an exercise in futility? Eur Urol.
49 (2): 209-11. Epub, 2006.
Verhagen PC, van Duijn PW, Hermans KG, Jooijenga LH, van Gurp RJ, Stoop H, Van der Kwast TH, Trapman J. The
PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion. J Pathol. 208
(5): 699-707, 2006.
Gosselaar C, Roobol MJ, Roemeling S, de Vries SH, Cruijsen-Koeter I, Van der Kwast TH, Schroder FH. Screening
for prostate cancer without digital rectal examination and transrectal ultrasound: results after four years in the
European Randomized Study of Screening for Prostate Cancer (ERSPC), Rotterdam. Prostate. 66 (6): 625-31, 2006.
Van der Kwast TH, Ciatto S, Martikainen PM, Hoedemacker R, Laurila M, Pihl CG, Hugosson J, Neetens I, Nelen V,
Di Lollo S, Roobol MJ, Maatanen L, Santonja C, Moss S, Schroder FH. Detection rates of high-grade prostate cancer
during subsequent screening visits. Results of the European Randomized Screening Study for Prostate Cancer. Int J
Cancer: 118 (10): 2538-42, 2006.
| 67
Dr. Sandra Viero
Price VE, Fletcher JA, Zielenska M, Cole W, Viero S, Manson DE, Stuart M, Pappo AS: Imatinib mesylate: an
attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans. Pediatr
Blood Cancer, 44:1-5, 2005.
Jaeger MRO, Viero S, Zuker RM: Cutaneous ganglioneuroma within a giant congenital nevus. Can J Plast Surg,
13(1):39-42, 2005.
Somers GS, Viero S, Teshima I, Nathan P, Zielenska M. Association of the t(12;22)(q13;q12) EWS/ATF1
rearrangement with primary sarcoma of bone. American Journal of Surgical Pathology, 29:1673-1679, 2005.
Edwards V, Cutz E, Viero S, Moore AM, Nogee L. Ultrastructure of lamellar bodies in congenital surfactant
deficiency. Ultrastructural Pathology, 29(6):503-509, 2005.
Bader R, Hornberger LK, Nijmeh LJ, Al-Kazaleh F, Ryan G, Toi A, Viero S, Butany J, Chitayat D. Fetal pericardial
teratoma: presentation of two cases and review of literature. Am J Perinatol, 23(1):53-8, 2006.
Alkazaleh F, Chaddha V, Viero S, Malik A, Anastasiadis C, Sroka H, Chitayat D, Toi A, Windrim R, Kingdom J:
Second trimester prediction of severe placental implications in women with combined elevations in alphafetoprotein and human chorionic gonadotrophin. American Journal of Obstetrics and Gynecology, 194:821-7,
2006.
Yeung J, Somers G, Viero S, Pope E: Multifocal lymphangioendotheliomatosis with thrombocytopenia. Journal of
the American Academy of Dermatology, 54:S214-217, 2006.
Milic A, Blaser S, Robinson A, Viero S, Halliday W, Winsor E, Toi A, Thomas M, Chitayat D: Prenatal detection of
microtia by MRI in a fetus with trisomy 22. Pediatr Radiol, 2006 Epub.
Baker JM, Viero S, Kim PC, Grant RM. Stage III Cystic Partially Differentiated Nephroblastoma recurring after
nephrectomy and chemotherapy. Pediatric Blood and Cancer, 2006 Epub.
Dr. Reinhold Vieth
Chow E, Hoskin PJ, Wu J, Roos D, van der Linden Y, Hartsell W, Vieth R, Wilson C, Pater J.A phase III international
randomised trial comparing single with multiple fractions for re-irradiation of painful bone metastases: National
Cancer Institute Of Canada Clinical Trials Group (NCIC CTG) SC 20.Clin Oncol (R Coll Radiol). Mar;18(2):125-8,
2006.
Vieth R, Kimball S, Vitamin D in congestive heart failure, Am J Clin Nutr. 2006 Apr;83(4):731-2.R Vieth. Critique
of the Considerations for Establishing Tolerable Upper Intake Levels for Vitamin D. J Nutr. 136(4):1117-22, 2006.
El-Hajj FG, Nabulsi M, Tamim H et al. Effect of vitamin D replacement on musculoskeletal parameters in school
children: a randomized controlled trial. J Clin Endocrinol Metab 91:405-12, 2006.
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status.
Osteoporos Int 16:713-6, 2005.
Vieth R, Cole DE. Teriparatide, osteoporosis, calcium, and vitamin D. N Engl J Med 353:634-5, 2005.
Vieth R. The role of vitamin D in the prevention of osteoporosis. Ann Med 37:278-85, 2005.
Vieth R, El-Hajj FG. There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D
concentrations increase. J Endocrinol Invest 28:183-6, 2005.
Vieth R, El-Hajj Fuleihan G. There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D
concentrations increase. J Endocrinol Invest 28:183-6, 2005.
Woo TC, Choo R, Jamieson M, Chander S, Vieth R. Pilot Study: Potential Role of Vitamin D (Cholecalciferol) in
Patients With PSA Relapse After Definitive Therapy. Nutr.Cancer 51:32-6, 2005.
Dr. Chen Wang
Zheng J, Ghazani A, Song Q, Mardyani S, Chan W, Wang C. Cellular imaging and surface marker labeling of
hematopoietic cells using quantum dot bioconjugates , Lab. Hematology, 12:94-98, 2006.
Dr. Elizabeth Winsor
Winsor EJT, Windrim R, Ryan G, Seaward G, Chitayat D, Akoury H Success rate for culture of fetal postmortem
tissue is dependent on the method of pregnancy termination. Fetal Diag Ther 20(4):306-308, 2005.
Kolomietz E, Godbole K, Winsor EJT, Stockley T, Seaward G, Chitayat D Functional disomy of Xp: prenatal findings
and postnatal outcome. Amer J Med Genetics 134A: 393-398, 2005.
Bruyere H, Speevak MD, Winsor EJT, de Freminville B, Farrell SA, McGowan-Jordan J, McGillivray B, Chitayat D,
McFadden D, Adouard V, Terespolsky D, Prieur F, Pantzar T, Hrynchak M. Isodicentric Yp: prenatal diagnosis and
outcome in twelve cases. Prenat Diagn 26: 324-329, 2006.
Milic A, Blaser S, Robinson A, Viero S, Halliday W, Winsor E, Toi A, Thomas M,
Chitayat D. Prenatal detection of microtia by MRI in a fetus with trisomy 22. Pediatr Radiol 36(7):706-710, 2006.
| 69
BOOKS & BOOK CHAPTERS
Dr. Bharati Bapat
Buonogiorno, P. and Bapat, B. Invited Chapter “Rho GTPases and Cancer”, in Developmental Biology of Neoplastic
Growth. Edited by Dr. Alvaro Macieira-Coelho. Springer-Verlag 2005.
Raptis, R., and Bapat, B. Invited Chapter “Genetic Instability in Human Tumors”, in Cancer: Cell Structures,
Carcinogens and Tumor Pathogenesis. Edited by Dr. L. Bignold. Birkhauser-Verlag, 2005. EXS 96: 303-320, 2006.
Zogopoulos G, Gallinger S: Modifiers of Risk in Familial Adenomatous Polyposis. Current Colorectal Cancer
Reports – Invited Review 2006.
MEDIA RECOGNITION
Dr. Reinhold Vieth
National Post, June National Post Tuesday, June 14, 2005 Page: FP23 Section: Financial Post: Comment Byline:
Reinhold Vieth. Financial Post Edition: National Story Type: Business; Opinion: A healthy tan: Excess exposure may
be hard on the skin, but the healthful effects of UV outweigh skin cancer and melanoma risks.
National Post, June National Post Tuesday, June 15, 2005 Page: FP23 Section: Financial Post: Comment Byline:
Reinhold Vieth. Financial Post Edition: National Story Type: Business; Opinion: ‘D’ depravation: There’s no problem
with vitamin D intakes to at least 10,000 units per day. But the junkiest science rules with an official safe limit of
only 1,000 units.
APPENDIX A
Medical and Scientific Staff as at June 30, 2006
Pathologist-in-Chief
Pritzker, Dr. K.P.H.
Medical Staff
Bédard, Dr. Yvan
Howarth, Dr. David
Mullen, Dr. Brendan
Shannon, Dr. Patrick
Bromberg, Dr. Irvin
Kandel, Dr. Rita
O’Malley, Dr. Frances
Van der Kwast, Dr. Theo
Colgan, Dr. Terry
Keating, Dr. Sarah
Pollett, Dr. Aaron
Wang, Dr. Chen
Fernandes, Dr. Bernard
MacMillan, Dr. Christina
Riddell, Dr. Robert
Associate Scientific Staff
Andrulis, Dr. Irene
Cruz, Dr. Tony
Hoffman, Dr. Barry
Özçelik, Dr. Hilmi
Azad, Dr. Azar
Denomme, Dr. Gregory
Khosravi, Dr. Javad
Renlund, Dr. Richard
Bapat, Dr. Bharati
Diamandis, Dr. Eleftherios
Kolomietz, Dr. Elena
Vieth, Dr. Reinhold
Chiang, Dr. Long
Grynpas, Dr. Marc
McKerlie, Dr. Colin
Winsor, Dr. Elizabeth
Fantus, Dr. George
Lajoie, Dr. Ginette
Ruijs, Dr. Theodora
Gallinger, Dr. Steven
Leong, Dr. Iona
Tenenbaum, Dr. Howard
Machin, Dr. Geoff
Summers, Dr. Anne
Luk, Dr. Shing Chark
Ritchie, Dr. Alex
Musclow, Dr. Elizabeth
Strawbridge, Dr. Harry
Associate Medical Staff
Asa, Dr. Sylvia
Chapman, Dr. William
Jarvi, Dr. Keith
Jong, Dr. Roland
Mock, Dr. David
Patterson, Dr. Bruce
Viero, Dr. Sandra
Consultant Staff
Blumenthal, Dr. Andrea
Gotlieb, Dr. Avrum
Honorary Medical Staff
Abbott, Dr. Derrick
Cooter, Dr. Noel
Nyburg, Dr. Stanley
Pollard, Dr. Alan
Research Associates
Gokgoz, Nalan
Dumitriu, Mircea
APPENDIX A (con’t)
Medical and Scientific Staff as at June 30, 2006
Administrative Support Staff
D’Mello, Mr. Vince, Administrative Director
Vaccaro, Ms. Anna,Supervisor, Financial & Professional Affairs
Mendes, Ms. Maria,Manager, Research Services
Krakower, Ms. Sandra,Manager, Rapid Response Laboratory
Hon, Mr. Joseph, Systems and Special Projects Officer
McPherson, Mr. David, Laboratory Information Systems Officer
Modi, Mr. Gaman, Quality Assurance Co-ordinator
Wilkins, Ms. Dorothy,Co-ordinator, Maternal Serum Screening Program
Tzountzouris, Mr. John, Supervisor, Genetics and Molecular Diagnostics
Bergeron, Ms. Nancy, Supervisor, Hematopathology
Wolff, Mr. Alan, Supervisor, Pathologists’ Assistants
Hutton, Ms. Nancy, Supervisor, Patient Services
Machin, Ms. Cynthia, Supervisor, Administrative Support Services (on leave)
Everson, Ms. Melody, Acting Supervisor, Administrative Support Services
Pirogowicz, Ms. Theresa, Assistant to Pathologist-in-Chief and Director
APPENDIX B
Technical & Support Staff as at June 30, 2005
Charge Technologists
Eva Cappa
Keith Lau
Technologists
Danny Appadoo
Mladenka Bilal
Ben Centeno
Hong Cheng
Megan Cook
Ranjit Dhariwal
Navin Dudhara
Laura Feness
Valentino Giorno
Jamshid Hadidi
Marta Hnatovska
Shukri Hirsi
Ian Kerr
Gordana Kuruzar
Holly Maddison
Debra McKay
Ionela Mitroi
Sathasivan Moodley
Anayo Okorie
Louis Papaeliou
Cynthia Pokulok
Mona Reid
Michelle Rodrigues
Carol Sandiford
Xiuhong Shi
Shelly Soloman
Shafqat Tahir
Jindra Tupy
John White
Jennifer Willis
Anna Wong
Monica Woroszchuk
Rebecca Yiu
Zoran Zilic
Bessie Carydis
Cecilia Moller
Cyndy Dunn
Ewa Latawiec
Jennifer Au
Glen Booth
Ann Chan
Yvonne Chin
Michelle Cornect
Zubeida Dinani
Tammy Earle
Kelly Fenwick
Nancy Good
Lynda Harrington
Doug Holmyard
Chetankumar Jariwala
Entela Ketri
Catherine Lacsamana
Usha Majeed
Maria Mendes
Angela Mitri
Jana Muravska
Pam Olins
Shakuntala Patel
Elena Ramachandran
Florence Reyes
Marianne Rogers
Manwinderjit Sangha
Theodora Shizas
Aida Stefan
Andrea Taylor
Kerri Tupy
Dorothy Wilkins
Anne Wilson Mathews
Jasmine Wong
Agnes Wozniarski
Danielle Yott
Angie Bansil
Audrey Braschel
Janet Chan
Kim Chrisztopulosz
Laurie Deboer
Nando Di Nicola
Carla Emanuele
Rafael Floro
Heather Goodchild
Seyeda Hasany
Patricia Hooshley-Inch
Donna Johnson
Samantha Kimball
Melanie Leffler
Lynette Manansingh
Ann Miller
Tatiana Mnich
Jiann Ng-Kcomt
Monica Orozco-Muga
Lumen Penaflorida
Rick Ramdhanie
Lisa Robinson
Eileen Ross
Teresa Selander
Teresa Shortill
Zuzanna Suler
Suzanna Tjan
Ruth Vives
Gloria Willer
Tony Wing
Marie Wong
Denise Yee
Brenda Zelazny
Melanie Bernabe
Aileen Brown
Rosalina Chan
Jan Church
Maria de la Vega
Keyur Dixit
Angelo Fefekos
NaiChong Gan
Clara Goodwin
Cherry Have
Glen Hopkins
Badry Kashafi
Joyce Kitazaki-Lee
Patrick Legault
Daniella Martino
Olga Mischuk
Jonathan Modo
Ruoyu Ni
Alice Pal
Jacqueline Pittman
Lily Ramyar
Mary Joe Rodrigues
A. Rucinska-Woznowski
Fredericka Shaw
Shirley Siu
David Swanson
Sandra Toma Paciocco
Trish Wegrynowski
Frances Williams
Catherine Winning
Martha Wood
Samuel Yesurathnam
Lorna Zilic
APPENDIX B (con’t)
Technical & Support Staff as at June 30, 2005
Technicians
Emanuel Abelha
Tammy Baliat
Layla Bhanji
Priscilla Chan
Jagath Dissanayake
Krystyna Golen
Elaine Isaac
Maureen Joseph
Jo Jo Lopez
Dana Miclea
Olga Ostrovsky
Phyllis Perreira
Anne Sankadayal
Avshag Shimova
Maria Tabujara
Maria Ackermann
June Bankasingh
Cecilia Bolarinho
Aileen Coore
Yasas Dissanayake
Ilona Gomolka
Angela Johnson
Iwona Kloc
Julie Marr
Maria Murdoch
Anita Patel
Carol Peters
Jo-Ann Santos
Carolyn Smart
Dorota Talkowska
Carmen Alimagno
Aileen Baretto
Vanessa Bothel
Elsa de Guzman Olarte
Domenica Filleti
Natalie Henry
Cassandra Johnson-Berry
Susan Lau
Orissia Masliak
Abiola Oduwole
Roslyn Payne Sealey
Maria Ramos
Alina Senkus
Ramesh Shah
Luz Vallarit
Linda Anjos
Raffi Berberian
Melody Cacao
Leonila de la Gana
Sukhwinder Girn
Elizabeth Iles
Joanna Jones
Susie Livingstone
Opal McDonald
Elsa Olarte
Sonia Pennant
Patricia Saban
Millicent Sharpe
Anna Szufnara
General Support Staff
Judy Austin
Ruth Krisa
Sylvia Perez
Maureen Spencer
Ursula Carter
Rosalinda Pizzuto
Julie Precious
Anna Tang
Domenica Filleti
Cynthia Machin
Chelo Shalland
Rina Varga
Soo Kim
Hassima Omar Ali
Claudia Sopora
Lab Informatics Staff
Tom Hatch
David McPherson
Anna Latour
Nurse
Lori Kingdon
Pathologists’ Assistants
Brian Chow
Sarah James
Autopsy Technician
Larry Quaranto
Megan Thompson
Alan Wolff
APPENDIX C
Technical & Support Staff Changes
Departures
Clerical Services
Ana Broomes
Rosanna Moutsanas
Cytopathology
Stephen Leung
Jacqueline Cheng
Elisabeth Miedema
Special Chemistry
Adnan Khan
Special Histology
Yasas Dissanayake
Entela Ketri
New Staff
Andrology
June Serote
Cytogenetics
Valerie Foster
Hematology
Wei Liu
Lisa Manning
Molecular Pathology
Megan Jensen
Matthew Vlasschaert
Patient Services
Sagar Bedakar
Special Chemistry
Homa Bondar
Special Histology
Julitta Drab
Mona Reid
Indra Narula
Isabelle Schell
APPENDIX D
Residents
Dickson, Brendan
Timonera, Elizabeth
Nair, Vidhya
Cunningham, Kristopher
Aljawad, Hameed
Aljerian, Khaldoon
Jaragh, Mohammad
Al-Shraim, Mubarak
Arwini, Ahmed
Hazrati, Lily-Naz
Winer, Daniel
Djordevic, Bojana
Kennedy, Meagan
Weinreb, Ilan
Craddock, Ken
Kepron, Charis
Gunapalan, Lalitha
Good, David
El Demallawy, Dina
Faghfoury, Hanna
Chung, Catherine
Akpan, Domenic
Kim, Susan
Van den Bosch, Ilse
Hancock, Laura
McDermott, Colleen
Baratz, Ari
Al-Riyami, Nihal
Lee, Sabrina
Fried, Eve
Sierra, Neelam
Wilson Myckan, Kerry
Spitzer, Rachel
Torres, Nathalia
Rai, Sundeep
Huynh, Quoc Hung
Barsuk, Daphna
Devon, Karen
Kundhal, Pavi
Asaria, Jamil
Gladdy, Rebecca
Chan, Ida
James, Susan
Gao, Zuhua
(Anatomic Pathology/Cytopathology)
(Anatomic Pathology)
(Anatomic Pathology/Gyne)
(Sarcoma)
(Surgical Pathology/Sarcoma)
(Cytopathology/Head and Neck)
(Sarcoma)
(Cytopathology)
(Sarcoma)
(Sarcoma)
(Anatomic Pathology/Sarcoma)
(Breast Pathology)
(Soft tissue/bone)
(Anatomic Pathology/Hemat)
(Hematopathology)
(Anatomic Pathology/Cytopathology)
(Fetal Pathology)
(Breast Pathology)
(Pathology elective – Nigeria)
(Gynepathology elective – UBC)
(Pathology elective – Holland)
(Pathology elective – England)
(Gynepathology elective)
(General Surgery)
(General Surgery)
(General Surgery)
(General Surgery)
(General Surgery)
(General Surgery)
(General Surgery)
(Radiology)
(Radiology)
(MD elective – GI Pathology)
APPENDIX E
Fellows
Las Heras, Facundo
MacNeill, Nicki
Dube, Valerie
Mulligan, Anna Marie
Bane, Anita
Curtis, Michael
George, Anne
Bishop, Karen
Kirsch, Richard
Hussein, Nusrat
(Bone and Soft tissue)
(Gyne)
(Gyne)
(Breast)
(Breast)
(Cytopathology)
(Cytogenetics)
(Fetal Pathology)
(GI Pathology)
(Fetal Pathology)
APPENDIX F
Graduate Students 2005-2006
Student
Supervisor
PhD or
MSc
Thesis Title/Project
Bane, Anita
Andrulis, Dr. Irene
MSc
Familial Breast Cancer: BRCA2 and Beyond, Histopathologic and Molecular Phenotype
Duygu, Acar
Andrulis, Dr. Irene
MSc
Identification of novel gains and losses in early onset of breast cancer by CGH
Huggins, Christopher
Andrulis, Dr. Irene
PhD
Identification of BRCA2 interacting proteins
Forse, Catherine
Andrulis, Dr. Irene
MSc
Identification of genes involved in lymphatic invasion in breast cancer
Keszei, Andras
Andrulis, Dr. Irene
PhD
Role of the thiazide-sensitive NaCe contransporter gene is essential hypertension
Lo, Winnie
Andrulis, Dr. Irene
MSc
Molecular analysis of osteosarcoma
Mastracci, Teresa
Andrulis, Dr. Irene
PhD
Methylation of the LAF-4 gene
Seto, Kelly
Andrulis, Dr. Irene
MSc
Identification of novel genetic changes during development and progression of ovarian
Buongiorno, Pinella
Bapat, Dr. Bharati
MSc
Analysis of downstream targets of Rac 1 GTPase and Wnt signaling pathway
Charames, George
Bapat, Dr. Bharati
PhD
Analysis of downstream targets of Rac 1 GTPase and Wnt signaling pathway
Esufali, Susie
Bapat, Dr. Bharati
PhD
Structure-function analysis of proteins integrating with ARM domain of tumor
Mrkonjic, Miralem
Bapat, Dr. Bharati
MSc
Perera, Sheron
Bapat, Dr. Bharati
MSc
Raptis, Roula
Bapat, Dr. Bharati
MSc
Association studies of MMR polymorphisms and colorectal cancer risk.
Borgono, Carla
Diamandis, Dr.
PhD
Human kallikrein 14: biological relevance and clinical significance
MSc
Proteomic discovery of potential biomarkers of chromosomal abnormalities from
cancer
suppression APC and its significance in Wnt pathway
The role of MMR SNP’s in the development of colorectal cancer in two Canadian
populations
Functional analysis of inherited genetic variants in MMR genes associated with CRC
predisposition
Eleftherios
Cho, Jane
Diamandis, Dr.
Eleftherios
Gunawardana, Geeth
Diamandis, Dr.
amniotic fluid
PhD
Eleftherios
Kulasingam, Vathany
Diamandis, Dr.
cancer
PhD
Eleftherios
Memari, Nader
Diamandis, Dr.
Identification of tumor associated antigents and their auto-antibodies in ovarian
Discovery of novel biomarkers for early breast cancer diagnosis using proteomics and
mass spectrometry
PhD
Cloning, protein purification and molecular characterization of hK12
PhD
The involvement of the kallikreins in neurogenative disease
MSc
Identification of tissue-specific kallikrein inhibitors
MSc
Identification of Novel Ovarian Cancer Biomarkers
MSc
Regulation of human kallikrein 6 in ovarian carcinoma
PhD
Characterization of human kallikrein 15: recombinant protein production, antibody
Eleftherios
Oikonomopoulou,
Diamandis, Dr.
Katerina
Eleftherios
Prassas, John
Diamandis, Dr.
Eleftherios
Sardana, Girish
Diamandis, Dr.
Eleftherios
Shan, Shannon
Diamandis, Dr.
Eleftherios
Shaw, Julie
Diamandis, Dr.
Eleftherios
generation, detection in body fluids and study of enzymatic activity and substrates.
Chiu, Andrew
Grynpas, Dr. Marc
MSc
Role of vanadium on bone remodelling in the rat model Phase II
Khan, Tayyab
Grynpas, Dr. Marc
MSc
Characterize the skeletal phenotype of the Sca-1 KO mice and identify the mechanistic
Omelon, Sidney
Grynpas, Dr. Marc
PhD
cellular pathways underlying it.
Mechanisms of formation and dissolution of calcium polyphosphates
Student
Supervisor
PhD or
MSc
Hunt, Tanya
Grynpas, Dr. Marc
MSc
Can Vitamin D delay or arrest the progression of osteoarthritis in an animal model
Rowe, Elizabeth
Grynpas, Dr. Marc
MSc
The Skeletal Effects of a Growth Hormone-Derived Peptide (AOD9604) in the Aged
Rat Model of Postmenopausal Osteoporosis.
Ue, Judy
Grynpas, Dr. Marc
MSc
The structure and chemistry of calcium polyphosphates
Wise, Lisa
Grynpas, Dr. Marc
PhD
Recombinant differentiation experiments on the Bax mouse model.
Wynnyckyj, Chrystia
Grynpas, Dr. Marc
PhD
Ex-vivo model on bone fatigue.
Arana, Claudia
Kandel, Dr. Rita
MSc
Effects of cartilage endplate on nucleus pulposus cells
Chang, Godfrey
Kandel, Dr. Rita
MSc
Growing annulus fibrosis on porous 3D silk scaffold.
Spiteri, Caroline
Kandel, Dr. Rita
MSc
Chondrocyte adhesion to CPP
St. Pierre, Jean-Phillipe
Kandel, Dr. Rita
PhD
Growing of deep zone chondrocytes onto titanium porous 3D scaffolds
Cho, Stewart
Ozcelik, Dr. Hilmi
MSc
Single Nucleotide Polymorphisms and the Ras Dependent Pathway: Recipe for cancer?
Fehringer, Gord
Ozcelik, Dr. Hilmi
PhD
Family based study of the association of the IGF-1 gene with breast cancer and breast
density
So, Grace
Pritzker, Dr. Kenneth
MSc
Alkaline phosphatase inhibitors and CPPD arthropathy
So, Pauline
MSc
Endogenous Inhibitors of Cartilage Alkaline Phosphatase and Calcium Pyrophosphate
Bielawski, Donna
Tenenbaum, Dr.
MSc
Crystal Deposition Disease
Howard
Girard, Bruno
Tenenbaum, Dr.
Neuropsychological cognitive predictors of treatment outcomes following
physiotherapy in patients with TMD
PhD
Bone cutting lasers
MSc
Pain and C-Fos expression in the brain
MSc
Effects of chronic orofacial pain on significant others in the family
PhD
Aryl hydrocarbons affect bone resorption and by inhibiting osteogenesis and these
Howard
Haytham, Ibrahim
Tenenbaum, Dr.
Howard
Muirhead, Vanessa
Tenenbaum, Dr.
Howard
Voronov, Irina
Tenenbaum, Dr.
Howard
effects can be reversed by Resveratrol in vitro.
APPENDIX F (con’t)
Graduate Students 2005-2006
Faculty of Applied Science and Engineering Undergraduate Project Students, Nanotechnology
Student
Supervisor
So, Grace
Characterization of Hydrophobic Fullerene Derivatives and Liposome Formulations for Potential
Materials Science and
Applications in Photodynamic Therapy
Engineering
Lee, Lawrence
Characterization and Gold-Doping of Hexadecaanilinated Carbon Nanotubes
Engineering Science
Faculty of Arts and Sciences, Laboratory Medicine and Pathobiology,
Undergraduate Project Students
Student
Supervisor
Hadzocos, Edward
Kandel, Dr. Rita
P53 and benign breast disease
Raizman, Igal
Kandel, Dr. Rita
Mechanical stimulation and its effect on the different zones of cartilage
Kanampuza, Jovil
Calcium Pyrophosphate Crystal Dissolution Studies
APPENDIX G
Post Doctoral Students
Student
Ilyushik, Edward
Supervisor
Andrulis, Dr. Irene
Identification and characterization of genes involved in breast cancer
risk and progression
Mejia-Guerrero, Salvador
Andrulis, Dr. Irene
Gene expression in sarcoma
Mulhall, Cara
Andrulis, Dr. Irene
Optical spectroscopy of breast tissue, IGF-1 and growth hormone in
Yan, Taiqong
Andrulis, Dr. Irene
Pethe, Vaijayanti
Bapat, Dr. Bharati
Methylation studies in colon cancer
Su, Brenda
Denomme, Dr. Greg
Effect of IVIG on toll-like receptor signaling.
Karakucuk-Koker, Inci
Protein Purification Techniques with FPLC and HPLC
Kishi, Tadaaki
1. Purification of hK8 from bacclovirus and clinical applications. 2.
youth with a family history of breast cancer
Identification of novel prognostic markers and therapeutic targets in
osteosarcoma.
Purification of hK7 from mammalian cells and clinical applications. 3.
Activation of kallikreins
Komatsu, Nahako,
Characterization of human kallikreins in skin by immunohistochemistry
Paliouras, Miltiades
Investigating the genetic regulation of kallikrein expression.
Moreno, Luisa
Grynpas, Dr. Marc
Fracture mechanics of bone in animal models
Anderca, Marinela
Kandel, Dr. Rita
Role of Sox family of transcription factors in modulating cartilage tissue
formation
DeCroos, Amritha
Kandel, Dr. Rita
Cell Signalling in Mechanically Stimulated in vitro grown articular
cartilage
Gan, Lu
Kandel, Dr. Rita
Design of Implant for Soft Tissue Attachment
Yang, Liu
Kandel, Dr. Rita
Biomaterial design and effect on anulus fibrosus tissue formation
Moskovtsev, Sergey
Mullen, Dr. Brendan
Sperm protamines and DNA integrity
Jarzanazi, Hamdi
Ozcelik, Dr. Hilmi
Trinucleotide repeat expansion in breast cancer
Onay, Venus
Ozcelik, Dr. Hilmi
Microarray approach to study the genetic polymorphisms in breast
cancer
Savas, Sevtap
Ozcelik, Dr. Hilmi
Study of SNP’s in DNA repair pathway and breast cancer risk using DNA
pooling strategy
Jahanmehr, Hamid
Wang, Dr. Chen
Computerized imaging analysis of hematopoietic cells
Zheng, Jianing
Wang, Dr. Chen
Flow cytometry analysis and cell sorting and characterization of RhoA
mutation in development and hematopoiesis
APPENDIX H
Summer Students May – August 2005
Student
Supervisor
Project Title
Alison Campbell
Dr. van der Kwast
Expression profiling of human tissue kallikrein 12 in breast and ovarian cancer
Cameron Ellis
Dr. Keating
Acquired in utero brain injury: the spectrum and chronicity of disease in unexpected
Jackie Fleischer
Dr. Bromberg
Carolyn Goard
Dr. Diamandis
Lara Gotha
Dr. Leong
Vincent Ho
Dr. Keating
Refractile Appearance of Misoprostol following Induction of Labour
Jovil Kanampuza
Dr. Pritzker
Inhibition of Alkaline Phosphatase by Cysteine Analogue Mercaptopyruvic acid:
stillbirths
Identifying the underlying regulatory mechanisms of dysregulated human tissue
kallikrein expression in ovarian cancer cells
Identification of single nucleotide polymorphisms (SNPs) within the human tissue
kallikrein locus: Functional implications and association to disease
Molecular characterization of human cord blood progenitors under various
osteogenic conditions
Implication for Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Ilana Kopolovic
Dr. Diamandis
Cloning, expression, and purification of proform and active form hk3 protein
Natala Kruglyk
Dr. Grynpas
Bone Mechanical Properties in Knock-Out Mouse Model of Oculodentodigital
Cynthia Kuk
Dr. Hoffman
Ronald Lai
Dr. Wang
Jonathan Micieli
Dr. Andrulis
Analysis of SOD2 and XRCC1 polymorphisms in soft tissue sarcomas
Stephanie Miller
Dr. Fernandes
The relationship of antibody titre to fetal anemia in hemolytic disease of the
Dysplasia
Characterization of newly generated antibodies and assessment of their utility as
biomarkers of cancer, an immunohistological approach
In Vitro Monitoring of proliferation of CLL (Chronic Lymphocytic Leukemia) cells by
Flow Cytometry
newborn
Stephanie Neufeld
Dr. Grynpas
The effects of N-butyryl glucosamine on bone quality in an ovariectomized rat
model
Igal Raizman
Dr. Kandel
The differential effects of mechanical stimulation on the zones of articular cartilage
Arbora Resulaj
Dr. Kandel
Perfusive culture system for annulus fibrosus tissue growth
Jenny Shu
Dr. Denomme
Effects of anti-Kell and anti- Glycophorin C on K562 and Progenitor Cells
Joseph Tota
Dr. Andrulis
Growth, Diet and Genetic Variation and Risk of Childhood Osteosarcoma - An
William Wong
Dr. Winsor
Reference Standards and Quality Assessment in a Clinical Cytogenetics Laboratory
Jing Zhang
Dr. Vieth
The determination of 1,25-dihydroxyvitamin D3 in human prostate tissues
Epidemiologic Study Proposal
APPENDIX I
Reportable Tests
Clinical Service Statistics
Tests (MIS)
SECTION
03/04
Technical Units (MIS)
04/05
05/06
03/04
04/05
05/06
Histopathology
746,090
798,045
892,268
4,711,093
5,296,038
5,821,490
Cytopathology
265,267
279,878
294,650
908,424
1,035,968
1,063,729
Blood Transfusion Services
224,152
244,254
261,859
772,874
864,621
908,121
Hematopathology
481,551
515,911
516,523
2,077,134
2,253,476
2,254,696
Biochemistry
2,447,160
2,648,992
2,996,655
3,175,541
3,542,836
3,710,675
Patient Services
96,677
109,770
113,728
695,580
792,945
820,090
Cytogenetics
7,342
8,388
10,170
1,494,870
1,608,836
2,083,009
TOTAL
4,286,635
4,605,248
5,085,853
14,004,368
15,414,720
16,661,810
CASES
SECTION
02/03
03/04
Surgical Pathology
17,990
17,447
04/05
18,417
05/06
18,861
Cytopathology
26,061
25,747
28,959
30,641
Autopsies
197
193
200
207
Bone Bank
197
167
309
299
Stone and Crystal Analysis
1,500
1,466
1,698
1,817
Reportable Tests
2003/04
Yr/Yr
2004/05
Yr/Yr
2005/06
MSH In-Patients
908,173
2%
959,504
6%
966,465
Yr/Yr
1%
MSH Out-Patients
1,103,338
-3%
1,262,696
14%
1,294,479
2%
Referred-In
214,207
21%
210,623
-2%
232,306
10%
Total
2,225,718
1%
2,444,559
10%
2,493,250
2%
APPENDIX I (con’t)
Reportable Tests
Pathology And Laboratory Medicine:
Technical And Support Staff F.t.e.
2002/03
2003/04
2004/05
2005/06
Administrative Director
1
1
1
1
Manager
4
5
5
5
Administrative Support
2
2
2
2
Information Systems Support
2
2
3
3
Technologists
118.82
127.12
131.2
131.2
Technicians
33.4
38.5
46.17
46.17
2
2
2
2
Medical/Scientific
9
9
6
6
Reporting clerk/dicta-typists
5
5
5.73
5.73
Pathologist Assistant
3.8
3.8
4
4
Morgue Attendant
1
1
1
1
Nurse
1
1
1
1
Receptionists
1.28
1.28
1.28
1.28
TOTAL
184.3
198.7
209.38
209.38
Secretaries
APPENDIX J
External Service Linkages
General Laboratory Service
• Hospitals In-Common Laboratory - selected biochemistry services
• The Baycrest Centre for Geriatric Care - microbiology, pathology, cytopathology, selected hematopathology, biochemistry
and Holter monitor services
• Toronto Rehabilitation Institute (all sites) - comprehensive laboratory, phlebotomy and electrocardiograph services
• Centre for Addiction and Mental Health (all sites)
• Humber River Regional Hospital (all sites)
selected laboratory services
• Lakeridge Health System
selected laboratory services
• Midwives Collectives of Toronto
• Selected specialized laboratory services for many hospitals throughout Ontario.
Clinical Trials Services
Independent investigators and corporations.
Preclinical Research and Development Services
For corporations in Canada, the United States and Europe.
APPENDIX K
April 2006 Departmental Rounds
PATHOLOGY AND LABORATORY MEDICINE ROUNDS – April 03-07, 2006
TIME
Monday
Tuesday
7:30 AM
Wednesday
Thursday
Friday
Gross Conference
Gross Conference
Staff Micro
Grossing Room
Grossing Room
(R. Kandel)
(M. Curtis)
Multi-header
Gyne Path
Room 663
8:00 AM
8:30 AM
Drs.Colgan/Chapman
Gross Conference
Gross Conference
Grossing Room
Grossing Room
Conference
9:00 AM
Room
9:30 AM
10:00 AM
11:00 AM
12:00 PM
* note below
01:00 PM
02:00 PM
Interesting &
Classical
Case Rounds
Room 663.
(R. Kirsch)
02:30 PM
03:00 PM
03:30 PM
04:00 PM
Dr. R.
Breast Tumour Board
Kandel
Sarcoma
The Group Room-12th
Rounds
04:30 PM
05:00 PM
floor
5th floor
Gyne
Radiology
Tumour
Dr. F. O’Malley
Board
IBD Rounds
GI/GI Surgery Rounds
- PMH
14th flr.
14th floor classroom
Classroom
05:30 PM
06:00 PM
Dr. R. Riddell
Dr. R. Riddell
APPENDIX K
TIME
Monday
Tuesday
7:30 AM
Wednesday
Thursday
Friday
Gyne Path
Room 663
Drs.Colgan/
Chapman
G
O
O
8:00 AM
8:30 AM
D
Gross Conference
Gross
Gross Conference
Gross Conference
Grossing Room
Conference
Grossing Room
Grossing Room
Grossing
(M. Curtis)
9:00 AM
F
R
Room
9:30 AM
I
10:00 AM
D
11:00 AM
12:00 PM
A
* note below
Y
01:00 PM
02:00 PM
Interesting & Classical
Case Rounds
Room 663.
(A.M. O’Shea)
02:30 PM
03:00 PM
03:30 PM
04:00 PM
Dr. R.
Breast Tumour Board
Kandel
04:30 PM
05:00 PM
05:30 PM
Sarcoma
The Group Room-12th
Rounds
floor
5th floor
Gyne
Radiology
Tumour
Dr. F. O’Malley
Board
IBD
- PMH
Rounds
14th flr.
Dr. R.
Dr. R. Riddell
Riddell
06:00 PM
APPENDIX K
TIME
Monday
7:30 AM
Tuesday
Wednesday
Thursday
Friday
Gross Conference
Gross Conference
Staff Micro Conference
Grossing Room
Grossing Room
(F. O’Malley)
Gyne Path
Room 663
Drs.Colgan/Chapman
8:00 AM
8:30 AM
Gross Conference
Grossing Room
E
9:00 AM
A
9:30 AM
S
10:00 AM
T
11:00 AM
E
12:00 PM
R
(M. Curtis)
Multi-header Room
01:00 PM
02:00 PM
Interesting & Classical
M
Case Rounds
O
Room 663.
02:30 PM
N
(M. Curtis)
03:00 PM
D
03:30 PM
A
04:00 PM
Y
Breast Tumour Board
The Group Room12th floor
04:30 PM
Dr. F. O’Malley
05:00 PM
05:30 PM
Dr. R. Riddell
APPENDIX K
TIME
Monday
Tuesday
7:30 AM
Wednesday
Thursday
Friday
Gross Conference
Gross Conference
Staff Micro
Grossing Room
Grossing Room
Gyne Path
Room 663
8:00 AM
Drs.Colgan/
Chapman
8:30 AM
Gross Conference
Gross
Conference
Grossing Room
Grossing Room
9:00 AM
Conference
(M. Curtis)
(M. Curtis)
Multi-header
Room
9:30 AM
10:00 AM
11:00 AM
12:00 PM
* note below
01:00 PM
02:00 PM
Interesting &
Classical
Case Rounds
Room 663.
(M. Curtis)
02:30 PM
Prof. O. Kallioniemi: “Microarray Technology in Cancer”
Workshop for Pathology Residents & Graduate Students
18th floor Auditorium
03:00 PM
03:30 PM
04:00 PM
Dr. R.
Breast Tumour
Kandel
Board
Sarcoma
The Group Room-
Rounds
04:30 PM
05:00 PM
Radiology
Tumour
Board
Pritzker
- PMH
Dr. F. O’Malley
IBD Rounds
GI/GI Surgery
Rounds
Memorial
14th flr.
14th floor
Lecture
Classroom
classroom
Prof. O.
Dr. R. Riddell
Dr. R. Riddell
“Translational
Cancer
Systems
Biology”
18th floor
Auditorium
06:00 PM
Gyne
Harold G.
Kallioniemi:
05:30 PM
12th floor
5th floor
��
600 University Avenue
Toronto, Ontario, Canada M5G 1X5

appendix a - Mount Sinai Hospital

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