lifestat 2008 - Deutsche Region der Internationalen Biometrischen

Transcription

First Conference of the
Central European Network
LIFESTAT 2008
Statistics and Life Sciences:
Perspectives and Challenges
54. Biometrisches Kolloquium / 25. ROeS Seminar
March 10 - 13, 2008
University of Munich
Geschwister-Scholl-Platz 1
80539 Munich, Germany
Conference organizers:
Joint biometric conference of the German Region (IBS-DR), the
Region Austria-Switzerland, (IBS-ROeS), and the Polish Group
(IBS Poland) of the International Biometric Society (IBS).
Contents
Contents
FOREWORD........................................................................................................................3
GREETING OF THE INTERNATIONAL BIOMETRIC SOCIETY...............................5
WELCOME..........................................................................................................................7
ACKNOWLEDGMENT ......................................................................................................9
COMMITTEES..................................................................................................................10
ORGANIZATION COMMITTEE ..............................................................................................10
INTERNATIONAL PROGRAM COMMITTEE .............................................................................10
LOCAL ORGANIZING COMMITTEE .......................................................................................10
CONFERENCE ORGANIZERS ................................................................................................10
GENERAL INFORMATION ............................................................................................11
CONFERENCE VENUE .........................................................................................................11
CONFERENCE REGISTRATION DESK .....................................................................................11
CLOAK ROOM ....................................................................................................................11
INTERNET ACCESS .............................................................................................................12
CONFERENCE AND TUTORIAL FEES .....................................................................................12
PHONE NUMBERS ...............................................................................................................12
FIRST AID ..........................................................................................................................12
ARRIVING IN MUNICH ........................................................................................................13
CAR PARKING ....................................................................................................................14
MUNICH’S PUBLIC TRANSPORT ..........................................................................................14
ACCOMMODATION.............................................................................................................15
LUNCHES, CATERING AND BEVERAGES ...............................................................................15
TOURIST INFORMATION .....................................................................................................15
TAXI .................................................................................................................................16
CHILDCARE .......................................................................................................................16
SCIENTIFIC PROGRAM .................................................................................................17
PROGRAM INFORMATION ...................................................................................................17
TUTORIALS .......................................................................................................................17
FLOORPLAN LUDWIG MAXIMILIANS UNIVERSITY..............................................18
LMU MAIN BUILDING: SECOND FLOOR ..............................................................................20
PROGRAM OVERVIEW..................................................................................................21
TIMETABLE SUNDAY, 9 MARCH 2008 ................................................................................21
TIMETABLE MONDAY, 10 MARCH 2008.............................................................................22
TIMETABLE TUESDAY, 11 MARCH 2008.............................................................................23
TIMETABLE WEDNESDAY, 12 MARCH 2008 .......................................................................24
TIMETABLE THURSDAY, 13 MARCH 2008 ..........................................................................25
1
LIFESTAT 2008: Statistics and Life Sciences
SESSIONS AND PRESENTATIONS................................................................................26
SESSIONS AND THEIR ORGANIZERS .....................................................................................26
INVITED SPEAKERS OF THE CONFERENCE ............................................................................26
PRESS CONFERENCE ...........................................................................................................27
CHAIRS .............................................................................................................................27
SOFTWARE DEMONSTRATION .............................................................................................27
MONDAY, 10 MARCH 2008.............................................................................................27
OPENING CEREMONY.........................................................................................................27
SESSIONS, LOCATIONS AND TIMES ......................................................................................28
TUESDAY, 11 MARCH 2008............................................................................................32
POSTER PRESENTATION ......................................................................................................37
WEDNESDAY, 12 MARCH 2008 .....................................................................................40
THURSDAY, 13 MARCH 2008.........................................................................................45
CLOSING SESSION ..............................................................................................................47
COMMITTEE SESSIONS / WORKING GROUP MEETINGS .....................................48
SOCIAL PROGRAM.........................................................................................................49
CULTURAL ACTIVITIES ...............................................................................................49
GUIDED SIGHTSEEING TOURS .............................................................................................50
LIST OF SPONSORS / EXHIBITORS .............................................................................51
INDEX OF CONFERENCE AUTHORS ..........................................................................52
March 10 – 13, 2008, Munich, Germany
2
Foreword
Foreword
Dear Participant, dear Reader,
Last year the Central European Network of the International Biometric Society (IBS) was
established and is currently comprising the German Region, the Austrian-Swiss Region and
the Polish group of the IBS. One of the main purposes of the network is to facilitate scientific
exchange in the area of biometrics among the member groups and regions of the IBS and to
organize joint meetings in which scientific exchange can take place.
The conference LIFESTAT 2008, Statistics and Life Sciences, is the first joint meeting of this
network with more than 200 paper and poster submissions from the three regions and groups.
Taking place in Munich the German Region took the lead in organizing this event. With the
dedicated support of the Austrian-Swiss Region and the Polish group, however, we hope that
it is notable already from the program and this abstract book that this conference goes beyond
a traditional Biometric Colloquium as held by the German Region every year and is
comprising ideas of the two other members of the network as well. We hope that this
conference fulfills already some of the objectives of the joint network and really enriches our
scientific perspectives in fruitful presentations and discussions with as many colleagues as
possible from all member regions and groups of the network.
Finally, it is also an honor for our network, that the president of the International Biometric
Society, Andrew Mead (UK), will be present at this first joint conference and will give a
presentation on experimental design and analysis approaches for large and complex timecourse gene expression microarray studies.
For this conference we organized a number of sessions on interesting and hot topics of
biometry. The backbone of the conference program is a series of introductory sessions on
topics as Flexible designs, Adaptive seamless design for combining phase II / III clinical
studies, Boosting for biomedical data, Non-inferiority trials, Bayesian modeling in
biostatistics, Cost efficient designs for biostatisticians, Genome-wide association studies and,
finally, Mapping approaches in plants and animals. We are happy that we have been able to
gain support in organizing these sessions by many well known colleagues as W. Maurer
(Basel), W. Brannath (Vienna), P. Bühlmann (Zurich), A. Munk (Göttingen) together with J.
Röhmel (Bremen), H. Dette (Bochum), I. R. König (Lübeck) and G. Freyer (Dummerstorf).
Other sessions were organized by the working groups (AGs, Sektionen) of our society and
reflect very well the diversity and the quality of biometry in our regions and groups: the
working group on non-parametric methods, on adaptive and multiple designs, on
pharmaceutical research, on agricultural experimentation, on population genetics and genome
analysis, on Bayesian methods, on statistical computation, on statistical methods in
bioinformatics, on ecology and environment protection, on statistical methods in medicine as
well as on spatial statistics. There are also contributed sessions which are reflecting the
present work of many active colleagues.
3
Foreword
We want to make the LIFESTAT 2008 conference interesting and attractive for all our
colleagues and to make it a first success and model for joint network meetings. We will
certainly monitor the results of this meeting to find out what we can improve for future
meetings.
Last but not least we would like to thank Ulrich Mansmann, Gerhard Tutz and the local
organizing committee for all their dedication and the many hours they have put into the
preparation of this meeting to make it a success. Only those who have organized such a
congress once really know how much work is really connected with it. We would also like to
thank the session chairs and all the presenters for their contributions to this conference.
Finally we hope that every participant will enjoy the conference and will be able to attend
many interesting sessions and to participate in many fruitful discussions.
Munich, March 2008
Ludwig A. Hothorn
Stanislaw Mejza
H. Ulrich Burger
(conference presidents)
4
Greeting of the International Biometric Society
Dear Participant, dear Reader,
It is a great pleasure to have been invited, as President of the International Biometric Society,
to attend LIFESTAT 2008, the first conference of the IBS Central European Network, in
Munich. I look forward to a scientific program containing talks from the usual diversity of
biometrical methodological topics and application areas that is the trademark of all IBS
Conferences, and to the many opportunities of meeting with colleagues from the constituent
parts of the IBS that comprise the Central European Network. The establishment of the
Central European Network, by the German and Austria-Swiss Regions and Polish National
Group of the IBS, reflects a continued change in the demography of the society in Europe,
and the perceived need to strengthen the underlying organization of the society.
This new network follows closely behind the establishment of the Channel Network, by the
Belgian, British and Irish, French and Netherlands Regions of the IBS in 2005, as a response
to a similar perceived need. I believe that both developments are to the overall benefit of the
IBS, and anticipate a further beneficial consolidation of Biometry and the IBS within Europe
over the next few years. Indeed, similar consolidation activities are being considered in other
parts of the IBS world, with current discussions about both a 'South-East Asia' Network and a
'Spanish-Speaking' Network, linking Europe with South and Central America, with all of
these activities following in the successful foot-steps of SUSAN, the Sub-Saharan African
Network.
As the IBS develops and moves forward with these plans, it is important to recognize and
retain the diversity of the society, as seen through the individual characters of each Region or
National Group, whilst benefiting from the strength provided through the linking of different
components of the society within a network. In particular, the Central European Network can
provide a focus for the development of the IBS into parts of Eastern Europe which have either
had a minimal IBS presence in the past, or, like the Hungarian National Group, have had a
variable presence. I look forward to the opportunity during my Presidency of working with
the members of the Central European Network to broaden the geographical footprint of the
society.
These networks also provide opportunities for individual members of the IBS working in
particularly specialized fields, to interact with a wider group of biometricians than those
within their own Region or National Group. I would encourage all IBS members to take
advantage of the great breadth of biometrical knowledge within our society, and to attend
meetings and conferences organized by the IBS throughout the world - since being elected
President-Elect I have been fortunate enough to be able to attend five IBS conferences in
different parts of the world, and to experience the wide diversity of biometry within our
society.
5
Of course, the diversity of the society will be showcased at our next International Biometric
Conference in Dublin, 13-18 July. I find myself in the unusual position of presiding at a
conference that I am also responsible for organizing. Having just reached the deadline for
contributed papers and posters, I am confident that the conference will be a scientific success,
and I hope that I will see many of you in Dublin in July.
Congratulations to the founders of the Central European Network on this timely development,
and to the organisers of this first Central European Network Conference for what I am sure
will be a highly successful conference.
Munich, March 2008
Andrew Mead
(IBS president)
6
Welcome
Welcome
Dear friends, dear colleagues,
the LIFESTAT 2008, conference will consolidate the three regions of the International
Biometry Society (IBS) – Poland, Germany, Switzerland/Austria – into the Central Europe
Network for the first time.
This new consortium will open up for further integration other smaller regional groups of IBS
(Czech Republic, Slovakia, Romania, Hungary, etc.) and will thus strengthen the potential for
development of Biostatistics in Eastern Europe. The conference will foster the exchange of
ideas, interests, research and industrial statisticians between Eastern Europe and the Germanspeaking scientific community.
The organizers chose “Statistics and Life Sciences” as a motto for this first conference of the
Central European Network, since molecular life sciences, medicine and epidemiology are the
framing, trendsetting subjects, which cannot be appropriately compiled or scientifically
interpreted without statistical methodology.
For today’s statisticians new contexts immerge from cooperation with the life scientists and
stimulated by this dialog, changes in thinking in statistical methods and development takes
place. The interaction between scientific and commercial organizations in the life sciences
brings to our field a dynamism which stimulates an attractive occupational picture of the
biostatistician.
Munich, with its scientific industrial infrastructure, is an ideal venue for discussions about
Statistics and Life Sciences. The integration of our colleagues from East Europe in the
formative processes and structures is an essential integration step in the process of
professional development of new statistical thinking.
European scientists from life sciences and statistics must position themselves creatively to
realize our potential to formulate our own unique vision and to compete successfully in the
world and the USA. The strengthening of the European position with our own unique
creativity, has become a necessity also as a result of economic developments in India and
China.
Recent events have led to a strengthening of European contributions in statistics and life
sciences to our society and to the international biometrical community. For example, in the
spring of 2007 channel Networks were created in which British, French, Dutch and Belgian
statisticians from the IBS united into a more focused federation.
7
Welcome
The establishment of the Central Europe Network should facilitate the environment for other
European networks including the integration of our East European colleagues in the existing
infrastructure and new infrastructures originating from common projects in epidemiology,
public health, ecology, agriculture, environment protection and health care
As we move toward shaping a new European trend in Statistics and Life Sciences, our vision
for this first conference of the Central European Network, LIFESTAT 2008, is to consciously
foster and strengthen personal working connections with our colleagues from East Europe.
This will open new communication channels and facilitate more efficient and better
representative organizational structures for our Central European Network and study groups.
We wish you stimulating days in Munich.
Munich, March 2008
Ulrich Mansmann
Gerhard Tutz
(local organizers)
8
Acknowledgment
Acknowledgment
We thank all people who spend time, energy, and enthusiasm in preparing this conference.
Their number is large and the project would be impossible without their strong effort.
We appreciate the generous support by the German Science Foundation, BAYHOST, and
several companies.
This financial support made it possible to invite a rich variety of speakers and provided
support for our colleagues from Central and East Europe to join the conference.
We are indebted to the administration of the Ludwig Maximilians University Munich, which
was extremely supportive in setting up the framework for our convention.
Finally we thank all colleagues who gave their scientific input, thus contributing to the special
atmosphere of this event.
We are looking forward to a stimulating meeting.
Best regards
Ludwig Hothorn
Ulrich Burger
Stanislaw Mejza
Ulrich Mansmann
Gerhard Tutz
9
Committees
Committees
Organization committee
Presidents
Hans Ulrich Burger (Basel)
Ludwig A. Hothorn (Hanover)
Stanislaw Mejza (Poznan)
International program committee
Andrea Berghold (Graz)
Heike Bickeböller (Göttingen)
Sylvia Frühwirth-Schnatter (Linz)
Leonhard Held (Zurich)
Jürgen Kübler (Basel)
Martina Mittlböck (Vienna)
Hans-Peter Piepho (Hohenheim)
Andreas Ziegler (Lübeck)
Local organizing committee
Institute of Medical Informatics, Biometrics and Epidemiology (IBE) and Institute for
Statistics, University of Munich:
Ursula Gerhardinger, Manuela Hummel, Marion Lotz-Fabry, Florian Leitenstorfer, Ulrich
Mansmann, Katharina Mildner, Karin Rieger, Markus Schmidberger, Karin Schmidt, Gerhard
Tutz, Brigitte Weber, Andrea Willnhammer.
Conference organizers
German Region (IBS-DR), the Region Austria-Switzerland (IBS-ROeS) and the Polish Group
(IBS Poland) of the International Biometric Society (IBS).
10
General information
General information
Conference venue
Main building of the Ludwig Maximilians University Munich
Geschwister-Scholl-Platz 1
80539 Munich
Accessible by public transport:
Underground line U3 or U6, “Universität” station
Conference bureau
phone: +49 (0) 89 / 2180-17990
fax: +49 (0) 89 / 2180 17991
Conference website
www.lifestat2008.de
Conference e-mail
[email protected]
Address of the Department of Statistics
Ludwigstraße 33, 80539 Munich (50 meters in direction “Siegestor”, building at the corner
Ludwigstraße/Akademiestraße).
Conference registration desk
The registration desks will be located on the first floor for the duration of the conference.
Opening hours:
Sunday, 9 March:
Monday, 10 March:
Tuesday, 11 March:
Wednesday, 12 March:
Thursday, 13 March:
17:00 – 19:00
7:30 – 19:00
8:00 – 19:00
8:00 – 18:00
8:00 – 14:00
Cloak room
The cloak room can be found on the ground floor of the University main building. You can
leave your jacket and your luggage there. The cloak room is opened daily during the
conference opening hours.
11
General information
Internet access
Participants of the conference can use the university’s computer-pools in the rooms F 008
(ground floor) and F 108 (first floor) daily from 8:00 till 24:00. You’ll find floor plans of the
university main building on pages 14–16.
The university’s WLAN networks can be used with your personal notebook as well.
Information about how to use the WLAN access is provided with the leaflet in your
conference bag.
Conference and tutorial fees
Conference
Tutorials
Standard
Day Ticket
Students
€ 80
€ 30
€ 25
Members of the IBS-DR, IBS-ROeS
and DAGStat societies
€ 200
€ 80
€ 50
Members of the IBS-Poland incl.
Czech Republic, Slovakia, Hungary,
Romania and Slovenia
Non-Members of the IBS or
DAGStat societies
€ 50
€ 250
€ 25
€ 120
€ 50
Phone numbers
Please remember that the prefix 089 is used if you are calling from outside the Munich
telephone district and +49 89 if you are calling from abroad.
First aid
In emergency case, please call the emergency number 112.
The nearest hospital to Munich’s University is the General Hospital Munich Schwabing,
Kölner Platz 1, 80804 Munich, phone: +49 (0)89–3068 0
12
General information
Arriving in Munich
The LMU Munich main building (Hauptgebäude), where the LIFESTAT 2008 conference
will take place, is located on Geschwister-Scholl-Platz. It’s a square that roughly abuts the
intersection of Ludwigstraße and Schellingstraße, just north of the city center. It has its own
U-Bahn (underground) station called “Universität“, which lies on the U3 and U6 lines. In the
back of the program booklet, there is a map of Munich’s Public Transport Network MVV.
Arriving by train (Deutsche Bahn)
Whether you arrive at the central train station (Hauptbahnhof) or at the eastern train station
(Ostbahnhof), all suburban trains from there pass through Marienplatz. There you can transfer
to the underground (U-Bahn). Underground lines U3 and U6 go to Univeristät station. From
Hauptbahnhof you can also take the underground lines U4 or the U5 to Odeonsplatz and
switch there to the line U3 (direction “Olympia Einkaufszentrum”) or U6 (direction
“Fröttmaning” or “Garching Forschungszentrum”).
13
General information
Arriving by plane at Munich Airport
Here you have two choices of public transportation: S-Bahn or Airport Bus.
S-Bahn
The suburban train, or S-Bahn, lines S8 and S1 each leave every 20 minutes from the airport
to the central train station. They take different routes, but both hit all the main city stations
and pass through “Marienplatz” in the heart of Munich. At “Marienplatz” you can transfer to
the U3 or U6 lines using the same ticket. The whole trip from airport to University takes
about 50 minutes.
Airport bus
The Lufthansa Airport Bus leaves the airport from various points every 20 minutes and costs
€ 9.50. The bus will take you to the U6 station “Nordfriedhof”, where you can change to the
U6 (in direction “Klinikum Grosshadern”) or to the central train station. Travel time: about 30
min. to “Nordfriedhof” / 40 min. to “Hauptbahnhof”.
Travelling by car
The autobahn leads you from all directions directly into the city centre: A 9 from Nuremberg
in the north, A 94 from Passau in the east, from the south the A 8 direction Salzburg as well
as the A 95 from Garmisch, from west the A 95 from Lindau and A 8 from Stuttgart.
Car parking
Like most European cities, Munich and especially the area around the University has very few
parking spots. We recommend as alternative the park and ride facilities P+R (see page 9) of
Munich's Public Transport and using suburban train, underground lines and bus.
If you want to try your luck and go into Munich by car, the charge for parking spots in the
area around the University is 2 €/hr, the maximum parking time is two hours. Only in the
Ludwigstraße there is free parking when using a parking disc with maximum parking time of
three hours.
Munich’s Public Transport
A four-day ticket for Munich’s Public Transport (MVV) is included in your conference bag.
In the back of the program booklet, there is a map of Munich’s Public Transportation
Network.
Further information see: www.mvv-muenchen.de
14
General information
Accommodation
List of pre-reserved hotels:
Single
Address / Telephone
Holiday Inn Munich
City North*****
Fleming’s Hotel Munich
Schwabing****
Cosmopolitan Hotel****
Hotel Königswache***
Carlton Hotel***
Savoy Hotel***
Hotel Stefanie garni
Double
(per room/night)
Leopoldstraße 194,
+49 (0)89–381790
Leopoldstraße 130-132,
+49 (0)89–2060900
Hohenzollernstraße 5,
+49 (0)89–383810
Steinheilstraße 7,
+49 (0)89–5427570
Fürstenstraße 12,
+49 (0)89–954757476
Amalienstraße 25,
+49 (0)89–28 78 70
Türkenstraße 35,
+49 (0)89–2881400
€ 140#
€ 140#
€ 134
€ 160
€ 120
€ 130
€ 105
€ 125
€ 99
€ 119
€ 99
€ 119
€ 77
#
breakfast not included
Lunches, catering and beverages
Light catering for purchase and beverages will be provided at the conference during and
between the sessions and presentations.
A variety of restaurants and cafes are in the neighborhood of the university. There is also a
student’s cafeteria called “Mensa" for hungry people to have lunch on Leopoldstraße 13a.
This food facility provides student meals at affordable prices. Tickets for dining in the
“Mensa” are sold at the conference information desk.
Tourist information
phone: +49 (0)89–233 96 500
e-mail: [email protected]
www.muenchen-tourist.de
Tourist Office at City Hall
Tourist Office at Central
Train Station
15
Address
Marienplatz 2
80331 Munich
Bahnhofsplatz 2
80335 Munich
Opening hours
Mon to Fri 10am - 8pm
Sat 10am – 4pm
Mon to Sat 9am - 8pm
Sun 10am - 6pm
General information
Opera and theatres
Below are the addresses of some of Munich's music theatres. Tickets can be ordered online,
but also by telephone:
•
•
•
•
Nationaltheater/Bayerische Staatsoper (Bavarian State Opera/Ballet)
Max-Joseph-Platz, 80539 Munich, phone: +49(0)89–2185 1920
www.bayerische.staatsoper.de
Münchner Kammerspiele (State Theatre)
Maximilianstraße 28, 80539 Munich, phone: +49(0)89–233 966 00
www.muenchner-kammerspiele.de
Bayerisches Staatsschauspiel (Bavarian State Theatre)
Max-Joseph-Platz 1, 80539 Munich, phone: +49(0)89–21 85 01
www.residenztheater.de
Deutsches Theater (Musical, Show, Entertainment)
Schwanthalerstraße 13, 80336 Munich, phone: +49(0)89–55 234 0
www.deutsches-theater.de
Museums, art and exhibitions
From antiquity to modern times, from the Old Masters to modern multi-media art: Munich is
an exciting place for everybody interested in art.
• Pinakothek der Moderne, Alte Pinakothek, Neue Pinakothek, www.pinakothek.de
• Gallery Lenbachhaus, Luisenstraße 33, 80333 Munich, www.lenbachhaus.de
• Haus der Kunst, Prinzregentenstraße 1, 80538 Munich, www.hausderkunst.de
• Deutsches Museum, Museumsinsel 1, 80538 Munich, www.deutsches-museum.de
Taxi
You can order a taxi by calling: Taxizentrale München +49(0)89-21610 or +49(0)89-19410 or
Isarfunk Taxizentrale +49(0)89-450540. Next to the university there is also a taxi stand in the
Leopoldstraße (western side of the “Siegestor“).
Childcare
Childcare can be provided on a hourly or daily basis. For detailed information please contact
[email protected] or the conference information desk.
16
Scientific program
Scientific program
Program information
Data projection
We will accept your presentation on CD or a USB Mass Storage Device. We are using
Windows XP. The presentation format can be a PowerPoint file or a PDF file. Presentations
should be prepared in English. If you have video clips inserted into your presentation please
ensure that you supply the video file as well as the PowerPoint file. Access to the internet is
not possible during presentation.
Poster presentation and session
Poster can be fixed starting Sunday 17:00 to panels with the number of your contribution. The
size of each panel is 90 cm (width) by 140 cm (height). The posters can be fixed with
adhesive tape (Scotch Tape). At the conference there are no facilities or resources for printing
posters.
Author-attended poster presentation will be held on Tuesday between 16:00 and 18:10,
registration for poster presentation is required untill March 1st. Authors are required to stand
by their posters for at least one-hour for discussion during poster session between 18:10 and
20:30.
Posters have to be removed on Thursday 14:00. No responsibility will be taken for posters,
which are left behind.
Tutorials
Sunday, 9 March 2008
14.00 - 18.00
Measurement error and misclassification in regression: Basics and some recent
developments
Chairs: Thomas Augustin and Helmut Küchenhoff, Department of Statistics at LMU
Munich
Location: A 021
Geoadditive regression
Chair: Thomas Kneib, Department of Statistics at LMU Munich
Location: A 014
Monday, 10 March 2008
8:30 - 11:45
Creating R packages
Chair: Friedrich Leisch, Department of Statistics at LMU Munich.
Location: A 014
17
Floorplan Ludwig Maximilians University
LMU main building: Ground floor
18
LMU main building: First floor
19
LMU main building: Second floor
20
Program overview
Program overview
Timetable Sunday, 9 March 2008
Time
14.0018.00
17:0019:00
14:00–18:00
14:00–18:00
Tut1:
Measurement Error
and Misclassification
in Regression
Tut2:
Geoadditive
Regression
Helmut Küchenhoff
Thomas Augustin
Thomas Kneip
DR)
17:00–19:00
A 014
Dept.
Statistics,
Seminar
Room
Early
Registration
A 021
15:00–18:00
Executive
Board (IBS-
Speerträger
Hall
19:00
Welcome Meeting
Restaurant Ratskeller, Marienplatz 8
21
Program overview
Timetable Monday, 10 March 2008
Time
9:1010:30
10:3011:00
8:30 11:45
Tut3:
Creating
R
Packages
F. Leisch
11:0012:40
A 014
S03: Genetic
S02: Diagnostic Epidemiology
Studies
(I)
S01: Systems Biology &
Bioinformatics
A 125
A 140
A 240
BREAK
Opening Ceremony, Audimax
Welcome: U. Mansmann (Local Organization), R. Putz (Vice
president, LMU), L. A. Hothorn (IBS-DR), U. Burger (IBS-ROeS),
S. Mejza (IBS Poland), A. Mead (President IBS)
Celebrating 50th anniversary of the Biometrical Journal: T. Friede
Keynote Lecture: J. Läuter
R
E
G
I
S
T
R
A
T
I
O
N
13:00-15:00
12:40–14:10
14:00–15:30
S04: Mapping
Approaches in
Plants &
Animals
14:10 - 15:30
S05:
Adaptive
Group
Sequential
Designs
S06:
Biostatistics at
Universities of
Applied
Sciences
A 140
A 125
A 240
15:30–16:00
16:00–18:30
18:00–
20:30
Munich
Highlight
Walk
LUNCH BREAK
S
p
e
e
r
t
r
ä
g
e
r
14:00-15:30
Medical
Biometry
Board
(GMDS)
Dep.Statistics,
Library
BREAK
S07:
Genome-wide
Association
Studies (I)
S08: Multiple
Testing
S09: NonInferiority
Trials (I)
S10: Freie
Themen (I)
A 240
A 125
A 140
A 014
H
a
l
l
18:00 – 20:00
Get Together, Senatssaal
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Program overview
Timetable Tuesday, 11 March 2008
Time
9:1010:30
S11: NonInferiority
Trials (II)
S12: Freie
Themen (II)
Audimax
A 014
10:30–11:00
11:00- S15: Flexible
12:40
Designs
Audimax
12:40-14:10
12:4014:10
Press
Conference
A 014
14:1015:30
S19: NonInferiority
Trials (III)
(Panel
discussion)
Audimax
S13: Event S14: Genetic
Data Analysis Epidemiology
(I)
(II)
A 125
A 240
BREAK
S16:
Agricultural
Science (I)
A 014
S17: Event
S18: Clinical
Data Analysis
Studies (I)
(II)
A 125
A 240
13:00-14:00
13:00-14:00
13:00-14:00
Dittrich &
Working
Partner
Working Group
Group NonStata
Clinical
Software Demo Spatial Statistics Statistics
A 125
A 140
A 240
S20:
S21: Advances
S22:
Genome-wide
in Statistical Agricultural
Association
Modelling (I) Science (II)
Studies (II)
A 240
A 125
A 014
R
E
G
I
S
T
R
A
T
I
O
N
S
p
e
e
r
t
r
ä
g
e
r
H
a
l
l
13:00-14:00
Session Off
Label
Committee
BFArM
A 021
13:00-15:00
Pinakothek
of Modern
Art
14:00-16:00
Myths and
Legends
15:30–16:00
BREAK
16:00-17:00 18:20-19:00 17:30-18:30
S23: Adaptive
Working
S24:
Spatial
Meeting
Working
Seamless
Group
Analysis of
Group
S25: Poster Mathematical Working
Design for
16:00Surveillance
Presentation
Group
Population
Combining
Models
in
18:10
Data
Phase II/III
Medicine and Executives Genetics and
Genome
Clinical Studies
Biology
Analysis
(Panel
Dept.
Dept.
discussion)
A 125
A 140
Statistics,
Statistics,
Library
Audimax
Seminar
A 021
Room
18:10- 20:30
18:10Poster Exhibition - Poster and Wine
20:30
Deanery Corridor (Dekanatsgang), Thomas Mann Hall
23
Program overview
Timetable Wednesday, 12 March 2008
Time
9:1010:30
S27:
S26a: Young
Structuring
Statistician
HighAwards (IBSDimensiona
DR)
l Data
S26b: Boosting
for High
Dimensional
A 125
Data
Audimax
10:30–11:00
11:0012:40
S30: Boosting
for Biomedical
Data
A 140
13:00-14:00
12:4014:10
Working Group
Pharmaceutical
Research
A 140
14:1015:30
S34: Bayesian
Models in
Biostatistics
(II)
A 140
15:30–16:00
BREAK
S31:
Advances
in
Statistical
Modelling
(III)
S28: Clinical
Studies (II)
A 140
parametric &
Parametric
Multivariate
Tests in High
Dimensions
A 125
S32:
Hierarchical
Models
S33:
Bayesian
Models in
Biostatistics
(I)
A 125
Dept. Statistics,
Library
13:00-14:00
Working
Group
Bayesian
Methods
A 125
13:00-14:00
Working Group
Statistical
Methods in
Bioinformatics
A 021
13:00-15:00
Munich
S37: Clinical Highlight Walk
Studies (III)
H
a
l
l
A 014
13:00-14:00
Working
Group Nonparametric
Methods
A 014
S36: Young
Statistician
Papers (IBSROeS)
Committee
Certificate
Medical
Biometry
S
P
e
e
r
t
r
ä
g
e
r
A 240
A 014
BREAK
16:00 - 18:10
Annual IBS-DR Member Meeting
20:00 - 24:00
Conference Dinner, Old Town Hall
Pre-meeting
BiomColloq
2009, Hanover
11:00-14:00
13:00-14:00
Working Group
Statistical
Methods in
Medicine
S35: Non-
A 240
R
e
g
i
s
t
r
a
t
i
o
n
10:00-11:00
A 021
A 240
Dept. Statistics,
Seminar Room
S29:
Advances in
Statistical
Modelling
(II)
Audimax
14:30-16:00
New
Pinakothek
16:00-17:30
Excursion
Lenbachhaus
(ROeS & IBS
Poland)
24
Program overview
Timetable Thursday, 13 March 2008
Time
9:1010:30
S38: Biological
Networks
S39: Meta-analysis
A 140
A 240
10:30–11:00
11:0012:40
S40: Additivity Tests
for Mixed Models
A 125
Registration
Speerträger
Hall
BREAK
S41: Cost Efficient
S42: Meta-analysis
Designs for
and Meta-regression
Biostatisticians
A 140
A 240
S43: Statistical
Methods in
Environmental
Monitoring
A 125
11:00-12:00
Working Group
Statistical
Computation
A014
Closing session, Audimax
Goodbye: Gerhard Tutz (Munich)
Keynote lecture: Jürg Hüsler (Bern)
12:5013:30
Working Group
14:00Methodology of
17:00 Systematic Reviews
(GMDS)
A 014
25
Sessions and presentations
Sessions and presentations
Sessions and their organizers
Systems Biology and Bioinformatics, Diagnostic Studies, Genetic Epidemiology (I), Mapping
Approaches in Plants and Animals (invited session organized by G. Freyer (Dummerstorf),
working groups Agricultural Experimentation, Population Genetics and Genome Analysis),
Adaptive Group Sequential Designs, Biostatistics Education at Universities of Applied
Sciences, Genome-wide Association Studies (I) (invited session organized by I. R. König
(Lübeck)), Multiple Testing, Non-Inferiority Trials (I) (invited session organized by J.
Röhmel (Bremen)), Freie Themen (I), Non-Inferiority Trials (II) (invited session organized by
A. Munk (Göttingen)), Freie Themen (II), Event Data Analysis (I), Genetic Epidemiology
(II), Flexible Designs (invited session organized by W. Brannath (Vienna)), Agricultural
Science (I), Event Data Analyses (II), Clinical studies (I), Non-Inferiority Trials (III) (invited
session organized by A. Munk (Göttingen) and J. Röhmel (Bremen)), Genome-wide
Association Studies (II), Advances in Statistical Modeling (I), Agricultural Science (II)
(invited session organized by H.-P. Piepho (Hohenheim)), Adaptive Seamless Design for
Combining Phase II/ III Clinical Studies (invited session organized by W. Maurer and M.
Branson (Basel)), Spatial Analysis of Surveillance Data (invited session organized by J.
Dreesmann (Hanover) working group Spatial Statistic), Young Statistician Awards (IBS-DR),
Structuring High-dimensional Data, Clinical Studies (II), Advances in Statistical Modeling
(II), Boosting for Biomedical Data (invited session organized by P. Bühlmann (Zurich)),
Advances in Statistical Modeling (III), Hierarchical Models (invited session organized by J.
König (Mainz) working group Bayesian Methods), Bayesian Models in Biostatistics (I),
Bayesian Models in Biostatistics (II) (invited session organized by L. Held (Zurich)),
Nonparametric and Parametric Multivariate Tests in High Dimensions (invited session
organized by E. Brunner (Göttingen) working group Nonparametric Methods), Young
Statistician Papers (IBS-ROeS), Clinical Studies (III), Biological Networks (invited session
organized by A. Benner (Heidelberg) and A. Tresch (Mainz) working group Statistical
Computation and Statistical Methods in Bioinformatics), Meta-analysis, Additivity Tests for
Mixed Models, Cost-efficient Designs for Biostatisticians (invited session organized by H.
Dette (Bochum)), Meta-analysis and Meta-regression (invited session organized by R. Bender
(Cologne) working group Statistical Methods in Medicine), Statistical Methods in
Environmental Monitoring.
Invited speakers of the conference
Fadoua Balabdaoui (Paris, France), Arne Bathke (Lexington, USA), Tim Beissbarth
(Heidelberg, Germany), Werner Brannath (Vienna, Austria), Peter Bühlmann (Zurich,
Switzerland), Leo Dempfle (Freising, Germany), Holger Dette (Bochum, Germany), David B.
Dunson (USA), Rohan Luigi Fernando (Ames, USA), Tim Friede (UK), Theo Gasser (Zurich,
Switzerland), Leonhard Held (Zurich, Switzerland), Torsten Hothorn (Munich, Germany), H.
M. James Hung (Silver Spring, USA), Meinhard Kieser (Heidelberg, Germany), Armin Koch
(Bonn, Germany), Peter Kraft (Cambridge, USA), Inke R. König (Lübeck, Germany), Jürgen
Läuter (Magdeburg, Germany), Michael Branson (Basel, Switzerland), Andrew Mead
(Warwick, UK), Matthias Mielke (Göttingen, Germany), Bertram Müller-Myhsok (Munich,
Germany), Martin Posch (Vienna, Austria), Michael Proschan (USA), William F.
26
Rosenberger (Fairfax, USA), Joachim Röhmel (Bremen, Germany), Stephen Senn (Glasgow,
UK), Christian Sonesson (Mölndal, Sweden), Simon G. Thompson (Cambridge, UK), SueJane Wang (Silver Spring, USA), Gernot Wassmer (Cologne, Germany).
Press conference
A press conference will be held on Thursday, 11 March, 12:40-14:10, in room A 014.
The press conference is not available to the public.
Chairs
At time of print setting not all chair proposals were confirmed, there may be minor changes.
Software demonstration
There will be Stata Software demonstrations by Dittrich & Partner, Consulting GmbH, on
Tuesday, 11 March 2008, 13:00 – 14:00, in room A140.
Opening Ceremony
Audimax
11:00 – 12:40
Chair: Ludwig A. Hothorn
Welcome
Ulrich Mansmann (Local Organization)
Reinhard Putz (Vice president, University of Munich)
Ludwig A. Hothorn (IBS-DR)
Ulrich Burger (IBS-ROeS)
Stanislaw Mejza (IBS Poland)
Andrew Mead (President IBS)
Celebrating the 50th anniversary of the Biometrical Journal
Tim Friede (Reading, UK)
Keynote lecture
Statistische Entscheidungen trotz riesiger Lösungsvielfalt – biometrische
Dateninterpretation und Modellbildung
Jürgen Läuter (Magdeburg)
27
Sessions, locations and times
Session
S01
Systems Biology and
Bioinformatics
Location
Time / Chair
A 125
9:10 - 10:30
Chairs: A.L. Boulesteix, R. Spang
9:10
Strimmer, Korbinian
A simple semiparametric approach to the
estimation of local and tail area-based false
discovery rates
9:30
Boulesteix, Anne-Laure;
Porzelius, Christine; Daumer, Martin
Additional predictive power of microarray
data and hybrid classifiers
9:50
Kammers, Kai; Rahnenführer, Jörg
Survival Models with Gene Groups as
Covariates
10:10
Analysing and interpreting gene expression
Repsilber, Dirk; Kern, Sabine; Selbig,
in heterogeneous tissues
Joachim; Jacobsen, Marc
A 140
9:10 - 10:30
Chairs: L. Edler, W. Lehmacher
S02
Diagnostic studies
9:10
Kopp-Schneider, Annette; Weimer,
Marc; Fabel, Michael
Assessing agreement in imaging studies with
continuous measurements - a case study
9:30
Burkholder, Iris; Kopp-Schneider,
Annette; Hoffmann, Sebastian;
Schneider, Klaus; Edler, Lutz
Sample sizes of multi-rater/multi-study
experiments when developing a quality
assessment tool in toxicology
9:50
Grouven, Ulrich; Bender, Ralf;
Küchenhoff, Helmut
10:10 Zapf, Antonia; Brunner, Edgar
S03
Genetic Epidemiology (I)
Estimating threshold values for minimum
provider volumes in total knee replacement
data
Comparison of different methods for
adjusting the area under the curve (AUC) for
covariates
A 240
9:10 - 10:30
Chairs: A. Ziegler, S. Wagenpfeil
Kulle Andreassen, Bettina; Frigessi,
A.; Edvardsen, H.; Kristensen, V.;
Wojnowski L.
Accounting for haplotype phase uncertainty
in LD estimation
9:30
Gerhard, Daniel
Rank Transformation in Haseman-Elston
Regression Using Scores for Location-Scale
Alternatives
9:50
Drozdz, Adrian; Szyda, Joanna
TagSNP selection in 19th human
chromosome based on HapMap data
9:10
28
Szymczak, Silke; Ziegler, Andreas;
10:10 Igl, Bernd-Wolfgang
Opening Session and Welcome
Läuter, Jürgen
S04
Mapping Approaches in Plants
and Animals
How to survive in a non-normal world: Are
mutual information or adaptive methods
sensible alternatives to parametric and
nonparametric ANOVA?
Audimax
11:00 - 12:40
Chair: L. A. Hothorn
Statistische Entscheidungen trotz riesiger
Lösungsvielfalt – biometrische
Dateninterpretation und Modellbildung
A 240
14:10 - 15:30
Chairs: G. Freyer, C. Stricker
Invited session organized by G. Freyer (Dummerstorf), working groups Agricultural
Experimentation plus Population Genetics and Genome Analysis
14:10
Fernando, Rohan Luigi; Stricker,
Christian
Stich, Benjamin; Jens Möhring, Jens;
Piepho, Hans-Peter; Heckenberger,
14:50
Martin; Buckler, Edward S.;
Melchinger, Albrecht E.
15:10
Neugebauer, Nadine; Guiard, Volker;
Reinsch, Nobert
S05
Adaptive Group Sequential Designs
14:10
Faldum, Andreas; Otto, Gert; Thies,
Jochen; Hommel, Gerhard
Alternative approaches for whole-genome
analyses
Mixed-model association mapping
approaches in wheat
It can be important to know the rate of
imprinting
A 140
14:10 - 15:30
Chairs: T. Friede, M. Posch
Strategies for Including Patients Recruited
During Interim Analysis of Clinical Trials
14:30 Müller, Hans-Helge; Pahl, Roman
Confidence Sets Following a Modified
Group Sequential Test
14:50 Hack, Niklas; Brannath, Werner
An algorithm for the calculation of exact
confidence intervals for adaptive group
sequential trials
15:10
29
Schneider, Astrid; Hommel, Gerhard;
Faldum, Andreas
Adaptive Designs with Optimal Sample
Size by Step Functions
S06
14:10
Biostatistics at Universities of
Applied Sciences
Tiedge, Jürgen
Schütt, Marion; Nicke, Barbara;
14:30 Swanton, Charles;
Berres, Manfred; Kschischo, Maik
14:50
Zvárová, Jana;
Martinková, Patricia; Zvára, Karel
15:10 Meister, Reinhard
S07
A 125
14:10 - 15:30
Chairs: D. Huscher, M. Neuhäuser
Lineare Modelle und Interpolation auf
unregelmäßigen Dreiecksnetzen für eine
effektive Nutzung der geographischen
Datenbasis bei ökologischen Aufgaben
Microarray meta-analysis identifies a
taxane response gene signature
Education in Biostatistics with the Support
of e-learning tools
Experiences in Teaching Applied Biometry
A 240
Genome-wide Association Studies (I)
16:00 - 18:10
Chairs: I. R. König, R. Foraita
Invited session organized by Inke R. König (Lübeck)
16:00 König, Inke R.; Ziegler, Andreas
16:20 Kraft, Peter
17:00 Müller-Myhsok, Bertram
17:30
Nothnagel, Michael; Caliebe, Amke;
Junge, Olaf; Krawczak, Michael
Ziegler, Andreas; Schwarz, Daniel F.;
17:50
Thompson, John R.; König, Inke R.
S08
Multiple Testing
16:00
Gontscharuk, Veronika; Finner,
Helmut
16:20
Straßburger, Klaus; Bretz, Frank;
Finner, Helmut
What are genome-wide association studies?
What a difference a year makes: Lessons
learned from early genome-wide
association scans
Quality control measures in genome-wide
association studies
Quality Management and Analysis of
Genomic High-throughput Data
Biostatistical Aspects of Quality Control in
Genome-Wide Association Studies Using
the Affymetrix Chip Technology
A 125
16:00 - 18:10
Chairs: F. Bretz, G. Hommel
A modified Bonferroni procedure with
plug-in estimator for the number of true
hypotheses
Ordered multiple comparisons with the best
and their applications in dose-response
studies
30
16:40 Hasler, Mario
A Multivariate Dunnett Procedure for
Correlated Endpoints
17:00 Duncker, Jakob; Hommel, Gerhard
Adaptive change of hierarchy of endpoints
in clinical trials after an interim analysis
17:20
Koenig, Franz; Stallard, Nigel; Friede,
Tim
Treatment Selection in Adaptive Groupsequential Designs
Resampling-based Procedure to Control for
the Generalized Familywise Error Rate
17: 40 Zierer, Astrid; Pigeot, Iris
S09
A 140
Non-Inferiority Trials (I)
16:00 - 18:10
Chairs: J. Röhmel, S. Senn
Invited session organized by J. Röhmel (Bremen)
16:00 Balabdaoui, Fadoua
The asymptotic distribution of the
likelihood ratio statistic under local and
fixed alternative with application in noninferiority trials
16:40 Kieser, Meinhard; Friede, Tim
Blinded Sample Size Reassessment in Noninferiority Studies – Review and New
Results
17:00 Hauschke, Dieter; Hothorn, Ludwig A.
Choice of Delta in Non-inferiority Studies:
Difference- versus Ratio-based Approach
17:20 Lloyd, Chris J.
Exact test of non-inferiority from binomial
data based on higher order asymptotic
pivotals
17:50
S10
16:00
Kropf, Siegfried; Kose, Daniela;
Hothorn, Ludwig A.
Freie Themen (I)
Multivariate Tests Based on Pairwise
Distance Measures
A 014
16:00 - 18:10
Chairs: F. Leisch, R. Vonk
Cechlarova, Katarina; Lacko, Vladimir; Kidney exchange programs: A simulation
Zezula, Ivan; Bena, Luboslav
study
16:20 Igl, Bernd-Wolfgang; Dümbgen, Lutz
Confidence rectangles in calibration using a
parametric bootstrap
Melsheimer, Oliver; Kunert, Joachim;
Roller, Markus; Wardenbach, Peter
Discussion of a model for the Carcinogenic
Potency of Fibers
16:40
17:00 Mau, Jochen
31
Medical Biometry in Academic Medicine:
Perspectives and Challenges
Tuesday, 11 March 2008
17:20 Feldmann, Uwe
17:40
Fried, Roland; Einbeck, Jochen;
Gather, Ursula
Adjusting Life Expectancy for Population
Ageing
Robust Filtering by Weighted Repeated
Medians
Session
S11
Location
Time / Chair
Audimax
9:10 - 10:30
Non-Inferiority Trials (II)
Chairs: M. Kieser, A. Munk
Invited session organized by A. Munk (Göttingen)
9:10
9:50
Hung, James H. M.
Challenges and Some Regulatory
Experiences with Non-Inferiority Trial
Design without Placebo Arm
Mielke, Matthias
The assessment of non-inferiority in a gold
standard design with censored,
exponentially distributed endpoints
10:10 Röhmel, Joachim
S12
Freie Themen (II)
On attempts to gain regulatory and ethic’s
committees’ acceptance for the 2-arm
active control non-inferiority trial
A 014
9:10 - 10:30
Chairs: A. Berghold, J. König
9:10
Vonthein, Reinhard
Estimation of a four state model when not
all patients are in one state initially
9:30
Kuhls, Silvia; Gather, Ursula; Imhoff,
Michael; Siebig, Sylvia; Wrede,
Christian
Clinical Validation of New Alarm
Algorithms in Intensive Care
9:50
Bender, Ralf; Grouven, Ulrich
Application of the Population Impact
Number (PIN) to Describe the Effect of
Interventions in the Entire Community
10:10
Grittner, Ulrike; Wicki, Matthias;
Gmel, Gerhard; Bloomfield, Kim
Imputation of missing longitudinal data:
different approaches
32
A 125
9:10 - 10:30
S13
Event Data Analysis (I)
9:10
Beyersmann, Jan; Wolkewitz, Martin;
Schumacher, Martin
The impact of time-dependent bias in
proportional hazards modelling.
9:30
Wienke, Andreas
Univariate and bivariate quadratic hazard
models
9:50
Hofner, Benjamin; Hartl, Wolfgang;
Küchenhoff, Helmut; Kneib, Thomas
Model choice in Cox-type additive hazard
regression models with time varying-effects
10:10
Buchholz, Anika; Sauerbrei, Willi;
Royston, Patrick
On time-varying effects in survival analysis
Chairs: L. Fahrmeir, M. Schumacher
A 240
09:10 - 10:30
S14
Genetic Epidemiology (II)
9:10
Foraita, Ronja
The Conditional Synergy Index to identify
a biological gene-gene-interaction
9:30
Suchocki, Tomasz Stefan; Szyda,
Joanna
The analysis of properties of the likelihood
ratio test for testing association between a
quantitative trait and SNP polymorphisms
under different parametrisations using
linear mixed models
9:50
Wittkowski, Knut M.; Song, Tingting
Diplotype µ-scores for Multipoint
Screening
10.10
Guenther, Frauke; Bammann, Karin;
Wawro, Nina
Neural networks modeling gene-gene
interactions
S15
Flexible Designs
Chairs: K. Strauch, J. Zvárová
Audimax
11:00 - 12:40
Chairs: W. Brannath, M. Vandemeulebroecke
Invited session organized by W. Brannath (Vienna)
11:00 Proschan, Michael
Flexible Methods in Clinical Trials
11:40 Friede, Tim; Henderson, Robin
Heterogeneity of Treatment Effect
Estimates across Design Stages in Adaptive
Trials
12:00 Wassmer, Gernot
On Multiarmed Adaptive Designs
33
S16
Agricultural Science (I)
A 014
11:00 - 12:40
Chairs: K. Emrich, S. Mejza
11:00 Piepho, Hans-Peter
Issues in the analysis of plant breeding and
variety trials
11:20 Łacka, Agnieszka; Kozlowska, Maria
Near-factorial experiments in a block
design with nested rows and columns for
plant protection research
11:40 Mejza, Stanislaw; Kachlicka, Danuta
Repeated Youden square with split units
12:00 Bauer, Andrea; Léon, Jens
Predicting Breeding Values of a Parental
Population of Self-Pollinated Crops
12:20 Möhring, Jens; Piepho, Hans-Peter
Comparison of one-stage and two-stage
analysis in series of experiments
S17
Event Data Analyses (II)
A 125
11:00 - 12:40
Chairs: J. Beyersmann, A. Wienke
11:00 Laubender, Rüdinger P.; Bender, Ralf
Estimating adjusted number needed to treat
(NNT) measures in the Cox regression
model
11:20 Stollenwerk, Björn; Siebert, Uwe
Setting cause-specific hazard ratios into
relation: derivation of a mathematical
function to be applied in decision-analytic
screening models
11:40
Allignol, Arthur; Beyersmann, Jan;
Schumacher, Martin
A Simulation Study to Assess the Bias of
the Variance Estimator of the Multivariate
Nelson-Aalen Estimator in Multistate
Models
12:00
Scheufele, Ramona;
Dietz, Ekkehart
Estimating relative risk of pressure ulcers
12:20 Sekula, Peggy; Schumacher, Martin
Analysis of case series - assumptions for
risk estimation using case-control like
approaches
34
S18
Clinical Studies (I)
A 240
11:00 - 12:40
Chairs: N. Victor, Z. Valenta
Valenta, Zdeněk; Slavíček, Aleš;
11:00 Černý, Libor; Lohynská, Radka;
Bahannan, Abdulrahman
Multiple Comparisons in Model–Based
Testing with Examples from Larynx Cancer
Research
11:20 Gilberg, Frank; Laguerre, Sandrine
A 2x2 Factorial Clinical Trial in Oncology
11:40 Bornkamp, Björn; Ickstadt, Katja
Bayesian Nonparametric Estimation of
Monotone Functions
12:00 Jung, Klaus; Brunner, Edgar
Combination of diagnostic markers with
regard to either 100% sensitivity or 100%
specificity
12:20
S19
Miller, Frank; Kieser, Meinhard;
Friede, Tim
Non-Inferiority Trials (III)
Blinded Assessment of Treatment Effects
Utilizing Information about the
Randomisation Procedure
Audimax
14:10 - 15:30
Chairs: D. Hauschke, N. Victor
Invited session organized by A. Munk (Göttingen) and J. Röhmel (Bremen)
Panel discussion
14:10 Senn, Stephen
S20
Genome-wide Association
Studies (II)
Non-inferiority Trials – Towards a New Paradigm
A 240
14:10 - 15:30
Chairs: H.-E. Wichmann, A. Ziegler
Genome-wide Association Studies of
Scherag, André; Hebebrand, Johannes;
Complex Traits and Strategies for Marker
Jöckel, K.H.
Validation
Finner, Helmut; Straßburger, Klaus;
How to link call rate and Hardy-Weinberg
Heid, Iris M.; Herder, Christian;
Rathmann, Wolfgang; Giani, Guido;
equilibrium as measures of genome-wide
14:30
SNP data quality - results from the KORA
Dickhaus, Thorsten; Lichtner, Peter;
Meitinger, Thomas; Wichmann, H.500K project
Erich; Illig, Thomas; Gieger, Christian
Testing for Association of GO Pathways in
14:50 Quehenberger, Franz
Genome Wide Association Studies
(GWAS)
14:10
35
Heid, Iris M; Lamina, Claudia; the
15:10 GIANT consortium, Gieger, Christian;
Wichmann, H.-Erich
S21
Advances in Statistical Modelling (I)
A GIANT on its way: Meta-analyses of
genomewide association studies
A 125
14:10 - 15:30
Chairs: A. Riebler, T. Kneib
14:10 Strobl, Carolin; Zeileis, Achim
Testing Variable Importance in Random
Forests - Strong Assumptions and Weak
Hypotheses
14:30 Binder, Harald; Sauerbrei, Willi
Knot Removal for Judging the Stability of
Additive Spline Model Fits
14:50 Klein, Daniel; Zezula, Jvan
15:10 Krumm, Bertram
S22
Agricultural science (II)
Maximum likelihood estimator in growth
curve model with serial correlation
structure
Exact vs. Common Logistic Regression. A
Comparison Based on the Criteria
"Feasibility" and "Maintaining of AlphaLevel" for Testing the Regression
Coefficient
A 014
14:10 - 15:30
Chairs: H.-P. Piepho, C. Richter
Invited session organized by H.-P. Piepho (Hohenheim)
Variance Components - Estimation
14:10 Dempfle, Leo
Methods and Applications
Experimental Design and Analysis
14:50 Mead, Andrew
approaches for Large and Complex Timecourse Gene Expression Microarray Studies
Adaptive seamless design for
Audimax
16:00 - 18:10
combining phase II / III
Chairs: M. Branson, W. Maurer
clinical studies
Invited session organized by W. Maurer und M. Branson (Basel)
Panel discussion
Combined phase II/III adaptive designs:
16:00 Branson, Michael; Maurer, Willi
Why are they needed?
S23
16:20 Wang, Sue-Jane
When are confirmatory adaptive designs
appropriate?
16:40 Posch, Martin
Statistical Analysis of Adaptive Designs:
Solutions and Open Problems
36
17:00 Brannath, Werner
Estimation following treatment selection in
flexible designs
17:20 Koch, Armin
EU regulatory guidance on phase II / III
combination trials
S24
Spatial Analysis of Surveillance Data
A 125
16:00 - 18:10
Chair: J. Dreesmann, C. Staubach
Invited Session organized by J. Dreesmann (Hanover),
working group Spatial Statistics
16:00 Sonesson, Christian
Space-time cluster detection using scan
statistics with examples in disease
surveillance and drug development
16:40 Höhle, Michael
Simulation and Inference for a Spatiotemporal Stochastic Epidemic Model
17:00 Fahrmeir, Ludwig; Khatab, Khaled
Geoadditive Latent Variable Models for
Analyzing Morbidity and Malnutrition
17:20 Scheipl, Fabian
Nonparametric Tests for Sparse Marked
Spatial Point Processes, with an application
to FISH Images
Wilking, Hendrik; Globig, A.; Unger,
F.; Kowalcyk, S.; Richter, S.; Ziller,
17:40
M.; Harder, T.; Conraths, F.J.;
Staubach, C.
Introduction of Highly Mobile Pathogens
into Germany and their Early Detection the National Surveillance Program for
Influenza Viruses in Wild Birds
A 140
S25
37
Poster presentation
16:00 – 18:10
Chairs: A. Crispin, G. Knapp,
T. Kneib, M. Nothnagel,
Chmiel, Izabela; Czupryna, Antoni;
Górkiewicz, Maciej; Brzostek,
Tomasz
Evaluation of the needs and route for long-term
rehabilitation in survivors of acute pancreatitis
Thygesen, Helene; de Menezes,
Renee X.; Boer, Judith M.
A Generic HMM Implementation for the Inference
of Latent Chromosomal States
Seybold, Martin P.; Wittkowski,
Knut M.; Schneider, Marion E.
A Multivariate Non-Parametric Approach to Select a
Biomarker Signature: Discriminating Between Two
Phagocytic Syndromes
Siatkowski, Idzi; Zyprych, Joanna
Analyse der Strukturblöcke mit
Nachbarschaftseffekten
Oliveiros, Barbara; Macedo,
Cristina; Ponciano, Emanuel;
Gomes Silva, Alexandre
Szafraniec, Krystyna; Wojtyniak,
Bogdan
Boyacioglu, Hulya; Boyacioglu,
Hayal
Gelbrich, Götz; Störk, Stefan;
Prettin, Christiane; Angermann,
Christiane
Spickenheuer, Anne; Kendzia,
Benjamin; Raulf-Heimsoth, Monika;
Ickstadt, Katja; Bruening, Thomas;
Pesch, Beate
Mejza, Iwona; Ambrozy, Katarzyna
Lamina, Claudia; Abecasis,
Goncalo; Wichmann, H.-Erich;
Kronenberg, Florian; Heid, Iris M.
Przystalski, Marcin; Piepho, HansPeter; Krajewski, P.
Adrion, Christine; Rückinger,
Simon; Mansmann, Ulrich
Analysis of student responses to BDI-II through
CFA and IRT
Application of nonparametric smoothing technique
to the assessment of acute health effects of air
pollution in Krakow, Poland
Assessment of Water Supply Systems in Turkey
Using Multivariate Statistical Methods
Co-Morbidities and Biomarkers in Heart Failure
Comparing of different regression models regarding
the inflammatory marker interleukin 8 in bitumenexposed workers
Constructions of incomplete split-plot x split-block
designs based on Kronecker type products
Do we gain from imputing ungenotyped SNPs in
genomewide association studies?
Environmentally specific assessment of genotypes in
different cropping systems
Generalized linear mixed models for counting
processes
Kombinierte Analyse experimenteller und klinischer
Genexpressionsdaten - eine Anwendung
Rosolowski, Maciej
hochdimensionaler Statistik
Population statistics and analysis of STR
Faltus, Václav; Zvárová, Jana
polymorphisms data using R and package forensic
Postelnicu, Tiberiu
Sample Size Determination for Case-Control Studies
Small sample comparisons of binomial probabilities:
Biebler, Karl-Ernst E.; Jäger, Bernd
Liebermeister’s test, Fisher’s exact test, exact odds
P.; Wodny, Michael
ratio confidence intervals
Skotarczak, Ewa; Szwaczkowski,
Some simulation studies under a threshold animal
Tomasz; Moliński, Krzysztof;
model with single gene effect
Dobek, Anita
Turnbull's nonparametric estimator and its
Lauseker, Michael; Pfirrmann,
application to the analysis of failure and suboptimal
Markus
response in chronic myeloid leukaemia (CML)
Glomb, Patricia; Ring, Arne
Use of baseline ECGs in the evaluation of thoroughQT studies with crossover design
Schaller, Mathias; Wöhrmann,
Andrej
Zeitveränderliche Variablen im Cox Modell
Daumer, Martin; Slawski, Martin;
Boulesteix, Anne-Laure
‘CMA‘-Steps in developing a comprehensive Rtoolbox for classification with microarray data and
other high-dimensional problems
38
Sedova, Michaela; Martinkova,
Patricia; Gabalec, Libor
Assessment and Comparison of Two Questionnaires
of Quality of Life in Crohn's Disease Patients
Reiczigel, Jenö; Brugger, Katharina; Bayesian analysis of a dynamical model for the
Rubel, Franz
spread of the USUTU virus
Werft, Wiebke; Benner, Axel
Identifying Molecular Predictive Marker in
Translational Clinical Trials
Götz, Anika; König, Inke R.;
Erdmann, Jeanette; Hothorn,
Ludwig A.; Wichmann, H.-Erich;
Samani, Nilesh; Schunkert,
Heribert; Ziegler, Andreas; on
behalf of the Cardiogenics and the
WTCCC group
A prospectively planned pooled meta-analysis of the
association between chromosome 9p21.3 and
coronary artery disease
Frequent Itemsets and Association Rules as
Supportive Analysis Tools in Genetic Association
Studies
Pahlke, Friedrich; König, Inke R.;
Training in Genetic Epidemiology - Implementation
Ziegler, Andreas; Bischoff, Michael of a technology based training course
A Model Selection Procedure with FWER-control
Mi, Xuefei
for the Binomial Change Point Problem
An empirical efficiency comparison of three factor
Ambrozy, Katarzyna; Mejza, Iwona
designs with nested and crossed treatment structures
Gerhardinger, Ursula; Markl,
Analyzing relapse free survival: Right censored
Gertraud E.; Mansmann, Ulrich
methods on interval censored data?
Application of Chow test to comparison of results of
Kozlowska, Maria; Kozlowski,
image analysis and conventional measurement in
Radoslaw J.; Górski, Romuald
plant protection
Müller, Tina; Ickstadt, Katja
Malinowska-Lipien, Iwona;
Comparing short-term efficacy of the healthKawalec, Ewa; Górkiewicz, Maciej;
promotion actions addressed to the same target
Brzostek, Tomasz
39
Kozlowska, Maria; Budka, Anna;
Górski, Romuald
Effect of Box-Cox transformation in model of
growth of fungus Trichoderma harzianum
Leissen, Sandra; Neuhäuser, Markus
Nonparametric Trend Tests for the Analysis of Right
Censored Survival Times
Kazmierczak, Katarzyna; Graczyk,
Malgorzata
Some notes about taking trials for estimation height
curve
Kuzmicz, Ilona; Górkiewicz,
Maciej; Brzostek, Tomasz
Tailoring the residential home facilities to structure
of the elderly patients needs
Simeckova, Marie; Rasch, Dieter
Additivity tests for the mixed model in the two way
ANOVA with single sub-class numbers - Type-Irisk of several tests
Wednesday, 12 March 2008
Katulska, Krystyna; Przybyl,
Katarzyna
On certain regular D-optimal Spring Balance
Weighing Designs
Knapp, Guido
Some Aspects on Bivariate Meta-Analysis
Wittenburg, Dörte; Guiard, Volker;
Teuscher, Friedrich; Reinsch, Norbert
Statistical modelling of within-litter variance in pig
Gregory, Martin; Pfeiffer, Karl-Peter;
Ulmer, Hanno; Strasak, Alexander M.
A SAS Macro for the Calculation of Relative Risks
from Non-Parametric Logistic Regression Models
using B-Splines
Farooqui, Mohammed Ali Z.
A Probalistic Fertility Model for First Conception
Nyári, Tibor
Screening for chlymydia trachomatis in
asymptomatic women in hungary. An
epidemiological and cost-effectiveness analysis
Session
Location
Time / Chair
Audimax
9:10 - 9:50
S26a
Young Statistician Awards (IBS-DR)
9:10
Inke R. König
Practical experiences on the necessity of
external validation
9:30
Holger Schwender
Detecting Interesting SNP Interactions with
logicFS
S26b
Boosting for High-dimensional Data
Chairs: J. Röhmel, A. Ziegler
Audimax
9:50 - 10:30
Chair: S. Mejza
Performance of bagging and boosting
depends on diversity of base classifiers
Cwiklinska-Jurkowska, Malgorzata;
Discrimination between non-genotoxic and
10:10 Burzykowski, Tomasz; Wietlicka-Piszc, genotoxic chemical compounds based on
Magdalena
cDNA microrray data
9:50
Cwiklinska-Jurkowska, Malgorzata
40
A 125
9:10 - 10:30
S27
Structuring High-dimensional Data
9:10
Rodrigues, Paulo Canas
Nonlinear Principal Component Analysis:
An Application
9:30
Selinski, Silvia; Ickstadt, Katja
Flexible Matching Coefficients for
Clustering Genetic Data
Gertheiss, Jan; Tutz, Gerhard
Feature Extraction in Signal Regression: A
Boosting Technique for Functional Data
Regression
9:50
Chairs: S. Frühwirth-Schnatter, K. Strimmer
Multivariate analysis of high dimensional
data: The one-sample statistic
10:10 Ahmad, M. Rauf; Brunner, Edgar
A 140
9:10 - 10:30
S28
Clinical Studies (II)
9:10
Strasak, Alexander M.; Pfeiffer, KarlPeter; Marinell, Gerhard; Göbel,
Georg; Ulmer, Hanno
A 46-Item Checklist for the Statistical
Evaluation of Medical Research
Manuscripts
9:30
Hildebrandt, Mandy; Vervölgyi, Elke;
Bender, Ralf
Calculating the NNT in RCTs with time-to
event data: a systematic review
9:50
Schwenke, Carsten
Sample Size Estimation for ClusterRandomized Clinical Trials
Chairs: H. U. Burger, J. Kübler
Determining the parameter settings of
different randomization methods for
specific study designs
Ofner-Kopeinig, Petra; Errath,
10:10
Maximilian; Berghold, Andrea
A 240
9:10 - 10:30
S29
Advances in Statistical Modelling (II)
9:10
Hartmann, Wolfgang
Using CMAT for Data Mining of Large
Data Sets
9:30
Svejdar, Viola; Augustin, Thomas;
Strobl, Carolin
Variable and Split Selection in
Classification Trees based on the Gini
Index - What if Values are Missing Not at
Random?
9:50
Neuhaus, Anneke; Augustin, Thomas;
Heumann, Christian; Daumer, Martin
A Review on Joint Models in Biometrical
Research
10:10
Schmidberger, Markus; Mansmann,
Ulrich
Parallelized preprocessing algorithms for
high-density oligonucleotide array data
41
Chair: H. Küchenhoff, K.-E. Biebler
S30
Boosting for Biomedical Data
A 140
11:00 - 12:40
Chairs: P. Bühlmann, G. Tutz
Invited session organized by P. Bühlmann (Zurich)
Boosting for High-Dimensional Data: an
11:00 Bühlmann, Peter
Introduction
11:20 Hothorn, Torsten
11:40
Kneib, Thomas; Hothorn, Torsten;
Tutz, Gerhard
Boosting for high-dimensional data:
Applications and software
Model choice and variable selection in
geoadditive regression models
12:00 Schmid, Matthias; Hothorn, Torsten
Boosting Additive Models using
Component-wise P-Splines
12:20 Binder, Harald; Schumacher, Martin
Mandatory Covariates in High-Dimensional
Survival Models Estimated by Boosting
S31
Advances in Statistical
Modelling (III)
A 240
11:00 - 12:40
Chairs: A. Benner, N. Benda
11:00 Sauerbrei, Willi; Royston, Patrick
Investigation of interactions between
treatment and continuous covariates by
fractional polynomial methodology
11:20 Rufibach, Kaspar; Held, Leonhard
Constrained estimation of regression
models with ordinal explanatory variables
Greven, Sonja; Crainiceanu, Ciprian;
11:40 Scheipl, Fabian; Küchenhoff, Helmut;
Peters, Annette
Inference in Additive and Linear Mixed
Models
12:00 Dabrowski, Andrzej L.
Logistic Models for Extreme Risk Data
12:20 Petry, Sebastian
Shrinkage Regression with Polytopes
A 014
S32
Hierarchical Models
11:00 - 12:40
Chairs: J. König, M. Zucknick
Invited session organized by J. König (Mainz), working group Bayesian Methods
On Using Extended Maximum Likelihood
11:00 Michalski, Andrzej
Principle to Hierarchical General Linear
Models
11:20
Thygesen, Helene; den Dunnen, Johan; A Hierarchical Poisson Model applied to
't Hoen, Peter-Bram
Solexa Gene Expression Data
42
11:40 Henschel, Volkmar; Engel, Jutta
Two level frailty models for institutional
quality assessment
12:00 Sigmund, Ralf; Nehmiz, Gerhard
Robustness of estimates in the cross-over
model against variance heterogeneity
12:20
Schmidtmann, Irene; Piroth, Tobias;
Urban, Peter Paul
S33
Bayesian Models in Biostatistics (I)
Comparing linear mixed models in
assessment of Parkinson dysphagia
A 125
11:00 - 12:40
Chairs: L. Held, D. B. Dunson
11:00 Zucknick, Manuela; Richardson, Sylvia
MCMC methods for gene expression
profiling via Bayesian variable selection
11:20 Sturtz, Sibylle; Ickstadt, Katja
Bayesian models for variables given on
disparate scales: An epidemiological
example
11:40 Riebler, Andrea; Held, Leonhard
Bayesian Age-Period-Cohort Models for
Detecting Temporal Patterns in Multivariate
Mortality Data
12:00 Wagner, Helga
Auxiliary Mixture Sampling for Dynamic
Survival Models
12:20 Paul, Michaela; Held, Leonhard
Multivariate Modelling of Infectious
Disease Surveillance Data
S34
Bayesian Models in Biostatistics (II)
A 140
14:10 - 15:30
Chairs: L. Held, K. Ickstadt
14:10 Dunson, David B.
Bayesian nonparametric modeling in
biostatistics
14:50 Held, Leonhard
Bayesian model selection by Markov Chain
Monte Carlo
15:10 McLeish, Don; Struthers, Cyntha A.
Modeling Longitudinal Data with
application to the Multicenter Aids Cohort
Study
43
S35
Nonparametric and Parametric
Multivariate Tests in High
Dimensions
A 125
14:10 - 15:30
Chairs: U. Munzel, M. Neuhäuser
Invited session organized by E. Brunner (Göttingen), working group Non-parametric Methods
14:10 Bathke, Arne; Harrar, Solomon
14:50
Konietschke, Frank;
Brunner, Edgar
15:10 Fidler, Vaclav
S36
Young Statistician Papers (IBSROeS)
14:10 Goll, Alexandra; Bauer, Peter
14:30
Templ, Matthias; Filzmoser, Peter;
Reimann, Clemens
Nonparametric and Parametric Multivariate
Tests
Nonparametric analysis of highdimensional repeated measures designs
A new model for rank-based regression
analysis
A 240
14:10 - 15:30
Chairs: A. Berghold, M. Mittlböck
Testing and model selection for prediction
in large sets of variables
Cluster analysis: Data preparation? Which
algorithm? How many clusters?
14:50 Scharl, Theresa; Leisch, Friedrich
Using Neighborhood Graphs for the
Investigation of Gene Clusters
15:10 Vock, Michael
Curves of Constant Power for 'One-Sided'
Bivariate Location Tests
S37
Clinical Studies (III)
14:10 Graf, Erika
A 014
14:10 - 15:30
Chairs: H. Wagner, H. Ulmer
Issues in comparing propensity score
stratification with linear regression to assess
a treatment effect
14:30
Stampf, Susanne; Graf, Erika;
Schmoor, Claudia
A simulation study on conditional and
marginal inference of propensity score
based approaches in comparison to linear
modeling
14:50
Frieler, Katja; Schink, Tania;
Hoffmann, Hans; Dewey, Marc
Limits of agreement for dependent data
15:10 Benda, Norbert
Time depending dose response modeling
44
Thursday, 13 March 2008
Session
S38
Biological Networks
Location
Time / Chair
A 140
9:10 - 10:30
Chairs: A. Benner, A. Tresch
Invited session organized by A. Benner (Heidelberg) and A. Tresch (Mainz),
working groups Statistical Computation and Statistical Methods in Bioinformatics
9:10
Beissbarth, Tim; Froehlich, Holger; Estimating Signaling Networks through
Fellmann, Mark; Sueltmann, Holger Nested Effects Models
9:50
Ackermann, Marit; Strimmer,
Korbinian
The Modular Structure Underlying Analyzes
of Gene Set Enrichment
Hummel, Manuela; Metzeler, Klaus
Association between a Prognostic Gene
10:10 H.; Bohlander, Stefan K.; Buske,
Signature and Functional Gene Sets
Christian; Mansmann, Ulrich
A 240
9:10 - 10:30
S39
Meta-analysis
9:10
Mittlböck, Martina; Heinzl, Harald
Measuring Heterogeneity in Meta-Analyses
Schlattmann, Peter
Comparison of four estimators of the
heterogeneity variance for meta-analysis when
the distribution of random effects is not
normal
9:50
Skipka, Guido
Use of the heterogeneity interval to distinguish
between the results of fixed and random
effects models in meta-analytic results
10:10
Rücker, Gerta; Schwarzer, Guido;
Carpenter, James R.
No events in both treatment arms - methods
for meta-analysis including zero studies
9:30
45
Chairs: R. Bender, J. Wellmann
S40
Additivity Tests for Mixed Models
9:10
Simeckova, Marie; Rasch, Dieter
9:30
Moder, Karl
9:50
Simecek, Petr; Simeckova, Marie
10:10
Rusch, Thomas; Rasch, Dieter;
Kubinger, Klaus D.
S41
A 125
9:10 - 10:30
Chair: D. Rasch
Additivity tests for the mixed model in the
two-way ANOVA with single subclass
numbers.
Additivity tests for the mixed model in the two
way ANOVA with single sub-class numbers A new approach to evaluate interaction in
block design.
way ANOVA with single sub-class numbers –
On a modification of Tukey´s test
way ANOVA with single sub-class numbers Robustness of additivity tests with binary
observations
A 140
Cost Efficient Designs for
Biostatisticians
11:00 - 12:40
Chairs: H. Dette, K. Moder
Invited session organized by H. Dette (Bochum)
11:00
Rosenberger, William F.; Sverdlov,
Oleksandr; Bristol-Myer Squibb
Handling Covariates in the Design of Clinical
Trials
11:40
Dette, Holger; Bretz, Frank;
Pepelyshev, Andrey; Pinheiro, José
Optimal designs for dose finding studies
12:20 Stanzel, Sven; Hilgers, Ralf-Dieter
S42
Meta-analysis and Metaregression
Construction of optimal designs for estimating
the treatment x cell line interaction effect in
two-colour cDNA microarray experiments
A 240
11:00 - 12:40
Chairs: M. Mittlböck, P. Schlattmann
Invited session organized by R. Bender (Cologne),
working group Statistical Methods in Medicine
Meta-analyses of observational
epidemiological studies based on individual
11:00 Thompson, Simon G.
participant data: combining within and
between study information
11:40 Wellmann, Jürgen
Meta-Regression of Response Ratios
46
Hamza, Taye H.; van Houwelingen,
Bivariate random effects meta-regression of
12:00 Hans C.; Heijenbrok-Kal, Majanka
diagnostic tests for Summary ROC curves
H.; Stijnen, Theo
Do Randomized and Non-Randomized Trials
Kuß, Oliver; Legler, Thomas;
Yield Different Answers in Similar
12:20
Börgermann, Jochen
Populations? - Evidence from a 'MetaPropensity Score' Analysis in Cardiac Surgery
S43
11:00
A 125
Statistical Methods in
Environmental Monitoring
11:00 - 12:40
Chairs: A. Nothdurft, L. Kuchar
Application of canonical variate analysis for
presenting ecological requirements of aquatic
plant communities
Kayzer, Dariusz; Szoszkiewicz,
Krzysztof
11:20 Kuchar, Leszek; Iwanski, Slawomir
Runoff Simulation in River Catchment Using
Spatial Weather Generator
Approaches to a large scale forest inventory by
Saborowski, Joachim; Mader, Felix;
11:40
subsampling of current two-phase designs for
Böckmann, Thomas
districts
12:00
Nothdurft, Arne; Saborowski,
Joachim
Regionalisation of Forest Stand Variables in
Baden-Württemberg
Aidaoui, Lakhdar; Zoras, Stamatis;
12:20 Azzi, Abbes; Papalexiou, Sofia;
Akermi, Nacreddine
Closing session
Statistical evaluation of mesoscale
photochemical pollution simulation results
Audimax
12:50 – 13:30
Chair: R. Vonk
Goodbye
Gerhard Tutz
Keynote lecture
Extremes in Biometrics
Jürg Hüsler (Bern)
47
Committee sessions and working group meetings
Committee sessions and working group meetings
Sunday, 9 March 2008
Location
Time
Department of Statistics,
Seminar Room
15:00 - 18:00
Library
14:00 - 15:30
Location
Time
Seminar Room
18:20-19:00
Session Off-Label Committee BFArM
A 021
13:00 - 14:00
Working Group Non-Clinical Statistics
A 240
13:00 - 14:00
Working Group Spatial Statistics
A 125
13:00 - 14:00
Working Group Population Genetics and
Genome Analysis
A 021
17:30 - 18:30
Working Group Mathematical Models in
Medicine and Biology
Library
16:00 - 17:00
Pre-meeting Biometric Colloquium 2009
Hanover
Location
Time
A 021
10:00 – 11:00
Library
11:00 - 14:00
Working Group Statistical Methods in
Bioinformatics
A 021
13:00 - 14:00
Working Group Pharmaceutical Research
A 140
13:00 - 14:00
Working Group Bayesian Methods
A 125
13:00 - 14:00
Working Group Non-parametric Methods
A 014
13:00 - 14:00
Seminar Room
13:00 - 14:00
Executive Board (IBS-DR)
Medical Biometry Board (GMDS)
Meeting Working Group Executives
Committee Certificate Medical Biometry
Working Group Statistical Methods in
Medicine
48
Social program / Cultural activities
Biometrical Society (IBS-DR) – Elections to
the Executive 2008
A 011
12:00 – 16:00
Annual IBS-DR Member Meeting
Audimax
16:00 -18:00
Location
Time
Working Group Statistical Computation
A 014
11:00 - 12:00
Working Group Methodology of Systematic
Reviews
A 014
14:00 - 17:00
Address of the Department of Statistics:
Ludwigstraße 33, 80539 Munich (50 meters in direction “Siegestor”, building at the corner
Ludwigstraße/Akademiestraße).
Social program
Sunday, 9 March - Welcome-Meeting 19:00
An informal welcome meeting will be held at the restaurant "Ratskeller".
Address: Marienplatz 8, 80331 Munich, accessible by underground lines U3 or U6,
“Marienplatz” station.
Monday, 10 March - Get-Together 18:00 – 20:00
“Senatssaal” of the university’s main building, Geschwister-Scholl-Platz 1.
Tuesday, 11 March - Poster and Wine 18:10 – 20:30
Deanery corridor (“Dekanatsgang”) and Thomas Mann Hall in the main building of the
University Munich, Geschwister-Scholl-Platz 1.
Wednesday, 12 March - Conference Dinner 20:00
The conference dinner will be an enjoyable evening in the spectacular venue of the Old Town
Hall at Marienplatz 15, 80331 Munich, accessible by underground lines U3 or U6,
“Marienplatz” station.
Tickets: conference participants: 45 € (10 € for students)
companions: 45 € (no reduction for students)
49
Cultural activities
Tour information
The sightseeing tours will start from outside the university’s main building. Meeting point is
the fountain in front of the LMU main building at Geschwister-Scholl-Platz 1. The guided
sightseeing tours will require about two hours. A limited number of tickets are available at the
conference registration desk.
Guided sightseeing tours
Munich Highlight Walk
13:00 – 15:00
This tour will take you on a trip through Munich city center and offers a variety of highlights.
You will see the most popular sights like the Marienplatz, Saint Peter’s church, the famous
grocery market (Viktualienmarkt) and hear the stories behind Munich’s history.
Cost: 10 €
Pinakothek of Modern Art 13:00 – 15:00
At present it is to be counted among Germany’s most popular museums. On this tour you will
be introduced to the themes and attitudes as well as the specific ideas and perspectives of
modern artists, and their products will be explained.
Cost: 10 € (entrance fee not included)
Myths and Legends
14:00 – 16:00
Once upon a time ... the famous architect of Munich’s Gothic cathedral made a deal with the
devil. There are many stories and fables told in Munich. On this tour we will enlighten you
about what you should believe and what you should discard as fancy superstition.
Cost: 10 €
Munich Highlight Walk
Cost: 10 €
13:00 - 15:00
New Pinakothek
14:30 – 16:00
The New Pinakothek exhibits a collection of paintings from the 19th century. Monet, Manet,
Renoir ... they are all represented with numerous fantastic works. Let us guide you through
one of the most dazzling centuries in the history of art.
Cost: 10 € (entrance fee not included)
50
List of sponsors / exhibitors
Excursion Lenbachhaus 16:00 – 17:00
The visit will guide through the collection of works by artists of the Blue Rider circle. The
tour is reserved primarily for members of the IBS-ROeS and IBS-Poland. We meet 15:30 in
front of the university’s main building at the fountain and then walk to the Lenbachhaus. The
tour through the museum starts 16:00.
Costs: 6 € entrance fee and 4 € for the guided tour
List of sponsors / exhibitors
Sponsors
Deutsche Forschungsgemeinschaft, Bonn, www.dfg.de; Bayer AG, Leverkusen,
www.bayer.de; Bayerisches Hochschulzentrum für Mittel-, Ost- und Südosteuropa
(BAYHOST), Regensburg, www.bayhost.de; Dittrich & Partner, Consulting GmbH,
Solingen, www.dpc.de; Glaxo Smith Kline, München, www.glaxosmithkline.de; Grünenthal
GmbH, Aachen, www.grunenthal.de; Koehler Pharma Biometrie Consulting GmbH,
Freiburg, www.koehler-freiburg.de; Meda Pharma, Bad Homburg, www.medapharma.de;
Merz Pharmaceuticals, Frankfurt, www.merz.de; Novartis Basel, www.novartis.ch; Roche
Diagnostics, Penzberg, www.roche.de; Roche Pharma, Basel, www.roche.ch; SAS
Deutschland, Heidelberg, www.sas.com; Schwabe Willmar, Karlsruhe, www.schwabe.de;
Schwarz Biosciences, Monheim, www.schwarzpharma.de; Wiley-VCH Verlag, Weinheim,
www.wiley-vch.de.
Exhibitors
51
•
Dittrich & Partner, Consulting GmbH, Solingen; www.dpc.de
•
Master’s Program Medical Biometry/Biostatistics at the University of Heidelberg;
www.biometrie.uni-heidelberg.de/master
•
Master Degree Programme in Epidemiology at the University of Munich, IBE;
mph-studiengang.web.med.uni-muenchen.de
•
Oldenbourg Wissenschaftsverlag, München; www.oldenbourg.de
•
Springer Verlag, Heidelberg; www.springer.com
•
Wiley-VCH Verlag, Weinheim; www.wiley-vch.de.
Index of conference authors
Abecasis, Goncalo, 38
Ackermann, Marit, 45
Adrion, Christine, 38
Ahmad, M. Rauf, 41
Aidaoui, Lakhdar, 47
Akermi, Nacreddine, 47
Allignol, Arthur, 34
Ambrozy, Katarzyna, 38, 39
Angermann, Christiane, 38
Augustin, Thomas, 41
Azzi, Abbes, 47
Bahannan, Abdulrahman, 35
Balabdaoui, Fadoua, 31
Bammann, Karin, 33
Bathke, Arne, 44
Bauer, Andrea, 34
Bauer, Peter, 44
Beissbarth, Tim, 45
Bena, Luboslav, 31
Benda, Norbert, 44
Bender, Ralf, 28, 32, 34, 41
Benner, Axel, 39
Berghold, Andrea, 41
Berres, Manfred, 30
Beyersmann, Jan, 33, 34
Biebler, Karl-Ernst E., 38
Binder, Harald, 36, 42
Bischoff, Michael, 39
Bloomfield, Kim, 32
Böckmann, Thomas, 47
Boer, Judith M, 37
Bohlander, Stefan K., 45
Börgermann, Jochen, 47
Bornkamp, Björn, 35
Boulesteix, Anne-Laure, 28, 39
Boyacioglu, Hayal, 38
Boyacioglu, Hulya, 38
Brannath, Werner, 29, 37
Branson, Michael, 36
Bretz, Frank, 30, 46
Bruening, Thomas, 38
Brugger, Katharina, 39
Brunner, Edgar, 28, 35, 41, 44
Brzostek, Tomasz, 37, 39, 40
Buchholz, Anika, 33
Buckler, Edward S., 29
Budka, Anna, 39
Bühlmann, Peter, 42
Burkholder, Iris, 28
Burzykowski, Tomasz, 40
Buske, Christian, 45
Caliebe, Amke, 30
Carpenter, James R., 45
Cechlarova, Katarina, 31
Černý, Libor, 35
Chmiel, Izabela, 37
Conraths, F.J., 37
Crainiceanu, Ciprian, 42
Cwiklinska-Jurkowska, Malgorzata, 40
Czupryna, Antoni, 37
Dabrowski, Andrzej L., 42
Daumer, Martin, 28, 39, 41
de Menezes, Renee X, 37
Dempfle, Leo, 36
den Dunnen, Johan, 42
Dette, Holger, 46
Dewey, Marc, 44
Dickhaus, Thorsten, 35
Dietz, Ekkehart, 34
Dobek, Anita, 38
Drozdz, Adrian, 28
Dümbgen, Lutz, 31
Duncker, Jakob, 31
Dunson, David B., 43
Edler, Lutz, 28
Edvardsen, H., 28
Einbeck, Jochen, 32
Engel, Jutta, 43
Erdmann, Jeanette, 39
Errath, Maximilian, 41
Fabel, Michael, 28
Fahrmeir, Ludwig, 37
Faldum, Andreas, 29
Faltus, Václav, 38
Farooqui, Mohammed Ali Z., 40
52
Feldmann, Uwe, 32
Fellmann, Mark, 45
Fernando, Rohan Luigi, 29
Fidler, Vaclav, 44
Filzmoser, Peter, 44
Finner, Helmut, 30, 35
Foraita, Ronja, 33
Fried, Roland, 32
Friede, Tim, 31, 33, 35
Frieler, Katja, 44
Frigessi, A., 28
Froehlich, Holger, 45
Gabalec, Libor, 39
Gather, Ursula, 32
Gelbrich, Götz, 38
Gerhard, Daniel, 28
Gerhardinger, Ursula, 39
Gertheiss, Jan, 41
Giani, Guido, 35
Gieger, Christian, 35, 36
Gilberg, Frank, 35
Globig, A., 37
Glomb, Patricia, 38
Gmel, Gerhard, 32
Göbel, Georg, 41
Goll, Alexandra, 44
Gomes Silva, Alexandre, 38
Gontscharuk, Veronika, 30
Górkiewicz, Maciej, 37, 39, 40
Górski, Romuald, 39
Götz, Anika, 39
Graczyk, Malgorzata, 39
Graf, Erika, 44
Gregory, Martin, 40
Greven, Sonja, 42
Grittner, Ulrike, 32
Grouven, Ulrich, 28, 32
Guiard, Volker, 29, 40
Hack, Niklas, 29
Hamza, Taye H., 47
Harder, T., 37
Harrar, Solomon, 44
Hartl, Wolfgang, 33
Hartmann, Wolfgang, 41
Hasler, Mario, 31
Hauschke, Dieter, 31
1
Hebebrand, Johannes, 35
Heckenberger, Martin, 29
Heid, Iris M, 35, 36, 38
Heijenbrok-Kal, Majanka H., 47
Heinzl, Harald, 45
Held, Leonhard, 42, 43
Henderson, Robin, 33
Henschel, Volkmar, 43
Herder, Christian, 35
Heumann, Christian, 41
Hildebrandt, Mandy, 41
Hilgers, Ralf-Dieter, 46
Hoffmann, Hans, 44
Hoffmann, Sebastian, 28
Hofner, Benjamin, 33
Höhle, Michael, 37
Hommel, Gerhard, 29, 31
Hothorn, Ludwig A., 31, 39
Hothorn, Torsten, 42
Hummel, Manuela, 45
Hung, James H. M., 32
Ickstadt, Katja, 35, 38, 39, 41, 43
Igl, Bernd-Wolfgang, 29, 31
Illig, Thomas, 35
Imhoff, Michael, 32
Iwanski, Slawomir, 47
Jacobsen, Marc, 28
Jäger, Bernd P., 38
Jens Möhring, Jens, 29
Jöckel, K.H., 35
Jung, Klaus, 35
Junge, Olaf, 30
Kachlicka, Danuta, 34
Kammers, Kai, 28
Katulska, Krystyna, 40
Kawalec, Ewa, 39
Kayzer, Dariusz, 47
Kazmierczak, Katarzyna, 39
Kendzia, Benjamin, 38
Kern, Sabine, 28
Khatab, Khaled, 37
Kieser, Meinhard, 31, 35
Klein, Daniel, 36
Knapp, Guido, 40
Kneib, Thomas, 33, 42
Koch, Armin, 37
Koenig, Franz, 31
Konietschke, Frank, 44
König, Inke R., 30, 39
Kopp-Schneider, Annette, 28
Kose, Daniela, 31
Kowalcyk, S., 37
Kozlowska, Maria, 34, 39
Kozlowski, Radoslaw J., 39
Kraft, Peter, 30
Krajewski, P., 38
Krawczak, Michael, 30
Kristensen, V., 28
Kronenberg, Florian, 38
Kropf, Siegfried, 31
Krumm, Bertram, 36
Kschischo, Maik, 30
Kubinger, Klaus D., 46
Kuchar, Leszek, 47
Küchenhoff, Helmut, 28, 33, 42
Kuhls, Silvia, 32
Kulle Andreassen, Bettina, 28
Kunert, Joachim, 31
Kuß, Oliver, 47
Kuzmicz, Ilona, 40
Łacka, Agnieszka, 34
Lacko, Vladimir, 31
Laguerre, Sandrine, 35
Lamina, Claudia, 36, 38
Laubender, Rüdinger P., 34
Lauseker, Michael, 38
Läuter, Jürgen, 29
Legler, Thomas, 47
Leisch, Friedrich, 44
Leissen, Sandra, 39
Léon, Jens, 34
Lichtner, Peter, 35
Lloyd, Chris J., 31
Lohynská, Radka, 35
Macedo, Cristina, 38
Mader, Felix, 47
Malinowska-Lipien, Iwona, 39
Mansmann, Ulrich, 38, 39, 41, 45
Marinell, Gerhard, 41
Markl, Gertraud E., 39
Martinkova, Patricia, 39
Mau, Jochen, 31
Maurer, Willi, 36
McLeish, Don, 43
Mead, Andrew, 36
Meister, Reinhard, 30
Meitinger, Thomas, 35
Mejza, Iwona, 38, 39
Mejza, Stanislaw, 34
Melchinger, Albrecht E., 29
Melsheimer, Oliver, 31
Metzeler, Klaus H., 45
Mi, Xuefei, 39
Michalski, Andrzej, 42
Mielke, Matthias, 32
Miller, Frank, 35
Mittlböck, Martina, 45
Moder, Karl, 46
Möhring, Jens, 34
Moliński, Krzysztof, 38
Müller, Hans-Helge, 29
Müller, Tina, 39
Müller-Myhsok, Bertram, 30
Nehmiz, Gerhard, 43
Neugebauer, Nadine, 29
Neuhaus, Anneke, 41
Neuhäuser, Markus, 39
Nicke, Barbara, 30
Nothdurft, Arne, 47
Nothnagel, Michael, 30
Ofner-Kopeinig, Petra, 41
Oliveiros, Barbara, 38
Otto, Gert, 29
Pahl, Roman, 29
Pahlke, Friedrich, 39
Papalexiou, Sofia, 47
Paul, Michaela, 43
Pepelyshev, Andrey, 46
Pesch, Beate, 38
Peters, Annette, 42
Petry, Sebastian, 42
Pfeiffer, Karl-Peter, 40, 41
Pfirrmann, Markus, 38
Piepho, Hans-Peter, 29, 34, 38
Pigeot, Iris, 31
Pinheiro, José, 46
2
Piroth, Tobias, 43
Ponciano, Emanuel, 38
Porzelius, Christine, 28
Posch, Martin, 36
Postelnicu, Tiberiu, 38
Prettin, Christiane, 38
Proschan, Michael, 33
Przybyl, Katarzyna, 40
Przystalski, Marcin, 38
Quehenberger, Franz, 35
Rahnenführer, Jörg, 28
Rasch, Dieter, 40, 46
Rathmann, Wolfgang, 35
Raulf-Heimsoth, Monika, 38
Reiczigel, Jenö, 39
Reimann, Clemens, 44
Reinsch, Nobert, 29
Repsilber, Dirk, 28
Richardson, Sylvia, 43
Richter, S., 37
Riebler, Andrea, 43
Ring, Arne, 38
Rodrigues, Paulo Canas, 41
Röhmel, Joachim, 32
Roller, Markus, 31
Rosenberger, William F., 46
Rosolowski, Maciej, 38
Royston, Patrick, 33, 42
Rubel, Franz, 39
Rücker, Gerta, 45
Rückinger, Simon, 38
Rufibach, Kaspar, 42
Rusch, Thomas, 46
Saborowski, Joachim, 47
Samani, Nilesh, 39
Sauerbrei, Willi, 33, 36, 42
Schaller, Mathias, 38
Scharl, Theresa, 44
Scheipl, Fabian, 37, 42
Scherag, André, 35
Scheufele, Ramona, 34
Schink, Tania, 44
Schlattmann, Peter, 45
Schmid, Matthias, 42
Schmidberger, Markus, 41
3
Schmidtmann, Irene, 43
Schmoor, Claudia, 44
Schneider, Astrid, 29
Schneider, Klaus, 28
Schneider, Marion E., 37
Schumacher, Martin, 33, 34, 42
Schunkert, Heribert, 39
Schütt, Marion, 30
Schwarz, Daniel F., 30
Schwarzer, Guido, 45
Schwenke, Carsten, 41
Sedova, Michaela, 39
Sekula, Peggy, 34
Selbig, Joachim, 28
Selinski, Silvia, 41
Senn, Stephen, 35
Seybold, Martin P., 37
Siatkowski, Idzi, 37
Siebert, Uwe, 34
Siebig, Sylvia, 32
Sigmund, Ralf, 43
Simecek, Petr, 46
Simeckova, Marie, 40, 46
Skipka, Guido, 45
Skotarczak, Ewa, 38
Slavíček, Aleš, 35
Slawski, Martin, 39
Sonesson, Christian, 37
Song, Tingting, 33
Spickenheuer, Anne, 38
Stallard, Nigel, 31
Stampf, Susanne, 44
Stanzel, Sven, 46
Staubach, C., 37
Stich, Benjamin, 29
Stijnen, Theo, 47
Stollenwerk, Björn, 34
Störk, Stefan, 38
Strasak, Alexander M., 40, 41
Straßburger, Klaus, 30, 35
Stricker, Christian, 29
Strimmer, Korbinian, 28, 45
Strobl, Carolin, 36, 41
Struthers, Cyntha A., 43
Sturtz, Sibylle, 43
Suchocki, Tomasz Stefan, 33
Sueltmann, Holger, 45
Svejdar, Viola, 41
Sverdlov, Oleksandr, 46
Swanton, Charles, 30
Szafraniec, Krystyna, 38
Szoszkiewicz, Krzysztof, 47
Szwaczkowski, Tomasz, 38
Szyda, Joanna, 28, 33
Szymczak, Silke, 29
't Hoen, Peter-Bram, 42
Templ, Matthias, 44
Teuscher, Friedrich, 40
Thies, Jochen, 29
Thompson, John R., 30
Thompson, Simon G., 46
Thygesen, Helene, 37, 42
Tiedge, Jürgen, 30
Tutz, Gerhard, 41, 42
Ulmer, Hanno, 40, 41
Unger, F., 37
Urban, Peter Paul, 43
Valenta, Zdeněk, 35
van Houwelingen, Hans C., 47
Vervölgyi, Elke, 41
Vock, Michael, 44
Vonthein, Reinhard, 32
Wagner, Helga, 43
Wang, Sue-Jane, 36
Wardenbach, Peter, 31
Wassmer, Gernot, 33
Wawro, Nina, 33
Weimer, Marc, 28
Wellmann, Jürgen, 46
Werft, Wiebke, 39
Wichmann, H.-Erich, 35, 36, 38, 39
Wicki, Matthias, 32
Wienke, Andreas, 33
Wietlicka-Piszc, Magdalena, 40
Wilking, Hendrik, 37
Wittenburg, Dörte, 40
Wittkowski, Knut M., 33, 37
Wodny, Michael, 38
Wöhrmann, Andrej, 38
Wojnowski L., 28
Wojtyniak, Bogdan, 38
Wolkewitz, Martin, 33
Wrede, Christian, 32
Zapf, Antonia, 28
Zeileis, Achim, 36
Zezula, Ivan, 31
Ziegler, Andreas, 29, 30, 39
Zierer, Astrid, 31
Ziller, M., 37
Zoras, Stamatis, 47
Zucknick, Manuela, 43
Zvára, Karel, 30
Zvárová, Jana, 30, 38
Zyprych, Joanna, 37
4
Notes
Notes
1
Notes
Notes
2
Notes
Notes
3

lifestat 2008 - Deutsche Region der Internationalen Biometrischen

Transcription

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